BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (329 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P52643 D-lactate dehydrogenase n=152 Tax=Bacteria RepID... 682 0.0 UniRef50_P44501 2-hydroxyacid dehydrogenase homolog n=103 Tax=ce... 503 e-141 UniRef50_Q8Z0N3 D-lactate dehydrogenase n=9 Tax=Bacteria RepID=Q... 400 e-110 UniRef50_Q31F74 D-isomer specific 2-hydroxyacid dehydrogenase, N... 384 e-105 UniRef50_B4SP29 D-isomer specific 2-hydroxyacid dehydrogenase NA... 362 8e-99 UniRef50_C7QLW6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 357 2e-97 UniRef50_Q4K893 D-lactate dehydrogenase n=15 Tax=Gammaproteobact... 354 3e-96 UniRef50_P30799 2-hydroxyacid dehydrogenase homolog n=7 Tax=Bact... 351 2e-95 UniRef50_D2LI76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 349 7e-95 UniRef50_B6HIS7 Pc21g23650 protein n=11 Tax=cellular organisms R... 349 7e-95 UniRef50_A9KHK7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 343 7e-93 UniRef50_UPI0001AEC4CE D-lactate dehydrogenase n=1 Tax=Alteromon... 342 8e-93 UniRef50_B2JFX7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 338 2e-91 UniRef50_B7KQC7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 332 1e-89 UniRef50_C0A4H0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 331 2e-89 UniRef50_B9ZMK9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 325 1e-87 UniRef50_Q22CX9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 323 5e-87 UniRef50_Q54UF7 Putative D-lactate dehydrogenase n=1 Tax=Dictyos... 313 4e-84 UniRef50_A0Q8P3 D-isomer specific 2-hydroxyacid dehydrogenase n=... 312 1e-83 UniRef50_B5EQZ7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 310 4e-83 UniRef50_A8SQC5 Putative uncharacterized protein n=4 Tax=Clostri... 308 2e-82 UniRef50_Q9P7Q1 2-hydroxyacid dehydrogenase homolog 2 n=2 Tax=Sc... 302 1e-80 UniRef50_C5K2M9 D-lactate dehydrogenase n=2 Tax=Ajellomyces derm... 299 9e-80 UniRef50_D2W085 Predicted protein n=1 Tax=Naegleria gruberi RepI... 296 5e-79 UniRef50_C9KNY1 D-lactate dehydrogenase n=2 Tax=Clostridiales Re... 296 8e-79 UniRef50_C1DZN2 D-Lactate dehydrogenase n=2 Tax=Micromonas RepID... 293 4e-78 UniRef50_C8W7M7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 290 4e-77 UniRef50_A8UL50 D-lactate dehydrogenase n=2 Tax=unclassified Fla... 286 1e-75 UniRef50_Q11QU3 D-lactate dehydrogenase n=1 Tax=Cytophaga hutchi... 280 4e-74 UniRef50_Q89388 A53R protein n=3 Tax=Chlorovirus RepID=Q89388_PBCV1 278 2e-73 UniRef50_B7S4E4 2-hydroxyacid dehydrogenase n=1 Tax=Phaeodactylu... 275 1e-72 UniRef50_C5P2R3 D-lactate dehydrogenase, putative n=5 Tax=cellul... 268 3e-70 UniRef50_D2QQC4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 265 1e-69 UniRef50_B5HCN2 D-lactate dehydrogenase n=6 Tax=Streptomyces Rep... 264 3e-69 UniRef50_C9NGL5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 264 3e-69 UniRef50_A4S3N1 Predicted protein n=2 Tax=Ostreococcus RepID=A4S... 263 8e-69 UniRef50_A7FYM9 D-lactate dehydrogenase n=10 Tax=Clostridium Rep... 254 2e-66 UniRef50_C4K7N1 Fermentative D-lactate dehydrogenase, NAD-depend... 246 1e-63 UniRef50_C4XEL0 Putative uncharacterized protein n=1 Tax=Mycopla... 235 2e-60 UniRef50_C4Z227 D-lactate dehydrogenase n=1 Tax=Eubacterium elig... 228 2e-58 UniRef50_C3WFC0 D-lactate dehydrogenase n=2 Tax=Bacteria RepID=C... 226 1e-57 UniRef50_D1PMF0 D-lactate dehydrogenase n=1 Tax=Subdoligranulum ... 222 1e-56 UniRef50_Q0SVM3 D-lactate dehydrogenase n=31 Tax=Bacteria RepID=... 214 2e-54 UniRef50_C8P1U4 D-lactate dehydrogenase n=1 Tax=Erysipelothrix r... 214 3e-54 UniRef50_B2UXX3 D-lactate dehydrogenase n=2 Tax=Clostridium RepI... 214 4e-54 UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 214 5e-54 UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 211 2e-53 UniRef50_C3RQ64 D-lactate dehydrogenase n=4 Tax=Bacteria RepID=C... 205 2e-51 UniRef50_C1BVE3 D-lactate dehydrogenase n=1 Tax=Lepeophtheirus s... 201 3e-50 UniRef50_C4F960 Putative uncharacterized protein n=2 Tax=Collins... 201 3e-50 UniRef50_A6LTK2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 199 2e-49 UniRef50_P17584 D-2-hydroxyisocaproate dehydrogenase n=9 Tax=Lac... 197 6e-49 UniRef50_P26297 D-lactate dehydrogenase n=73 Tax=Lactobacillales... 191 4e-47 UniRef50_Q59642 D-lactate dehydrogenase n=5 Tax=Lactobacillaceae... 190 6e-47 UniRef50_C0GGJ9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 190 6e-47 UniRef50_B1C8M4 Putative uncharacterized protein n=1 Tax=Anaerof... 189 1e-46 UniRef50_O83080 D-lactate dehydrogenase n=2 Tax=Treponema pallid... 188 2e-46 UniRef50_Q6RK69 D-lactate dehydrogenase n=4 Tax=Lactobacillus Re... 186 1e-45 UniRef50_A5VLZ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 183 7e-45 UniRef50_C1P7N1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 183 9e-45 UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 181 4e-44 UniRef50_O66939 D-lactate dehydrogenase n=1 Tax=Aquifex aeolicus... 179 2e-43 UniRef50_Q47748 D-specific alpha-keto acid dehydrogenase n=50 Ta... 178 2e-43 UniRef50_B2GCQ6 D-2-hydroxyisocaproate dehydrogenase n=3 Tax=Lac... 178 2e-43 UniRef50_B9DL13 D-specific D-2-hydroxyacid dehydrogenase n=4 Tax... 175 2e-42 UniRef50_C0QZF2 Lactate dehydrogenase-like dehydrogenase n=2 Tax... 172 1e-41 UniRef50_A5IXT8 D lactate dehydrogenase n=4 Tax=Mycoplasma RepID... 171 3e-41 UniRef50_C9BJM5 D-isomer specific 2-hydroxyacid dehydrogenase n=... 171 3e-41 UniRef50_A5VJC4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 171 4e-41 UniRef50_C2EUZ1 D-lactate dehydrogenase n=4 Tax=Lactobacillus Re... 170 6e-41 UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina R... 170 6e-41 UniRef50_Q036G7 Lactate dehydrogenase related 2-hydroxyacid dehy... 169 9e-41 UniRef50_C5NVX3 D-lactate dehydrogenase n=2 Tax=Bacilli RepID=C5... 167 3e-40 UniRef50_C8P020 D-lactate dehydrogenase n=1 Tax=Erysipelothrix r... 167 4e-40 UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 167 6e-40 UniRef50_C1DWX6 Glyoxylate reductase (Glycolate reductase) n=6 T... 164 3e-39 UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella pal... 164 3e-39 UniRef50_P63940 D-lactate dehydrogenase n=61 Tax=Bacilli RepID=L... 162 1e-38 UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellu... 160 4e-38 UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 T... 160 4e-38 UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostri... 160 6e-38 UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Arch... 159 1e-37 UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms ... 159 2e-37 UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, N... 159 2e-37 UniRef50_B1L1I5 D-lactate dehydrogenase n=16 Tax=Clostridium Rep... 158 3e-37 UniRef50_B2KDH0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 156 1e-36 UniRef50_B4RIC5 D-lactate dehydrogenase n=1 Tax=Phenylobacterium... 155 2e-36 UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister... 155 2e-36 UniRef50_Q98LH4 Phosphoglycerate dehydrogenase n=2 Tax=Mesorhizo... 154 3e-36 UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 154 5e-36 UniRef50_Q99ZM2 D-lactate dehydrogenase n=16 Tax=Bacilli RepID=L... 154 6e-36 UniRef50_Q047V3 Lactate dehydrogenase related 2-hydroxyacid dehy... 153 7e-36 UniRef50_A6Q114 D-isomer specific 2-hydroxyacid dehydrogenase, c... 153 8e-36 UniRef50_A8Z3G0 (R)-2-hydroxyacid dehydrogenase n=67 Tax=Bacilli... 153 8e-36 UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archa... 153 9e-36 UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 152 1e-35 UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, N... 152 1e-35 UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicy... 152 2e-35 UniRef50_C0WS24 D-lactate dehydrogenase n=6 Tax=Lactobacillus Re... 151 3e-35 UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NA... 150 7e-35 UniRef50_B4D8A9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 149 1e-34 UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dicty... 149 2e-34 UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases... 149 2e-34 UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyan... 148 3e-34 UniRef50_B7JZK0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 148 3e-34 UniRef50_C7TLC2 D-2-hydroxyacid dehydrogenase n=7 Tax=Lactobacil... 148 3e-34 UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Ther... 148 3e-34 UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clost... 147 5e-34 UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0... 146 1e-33 UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 146 1e-33 UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetoba... 145 2e-33 UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Eurya... 145 2e-33 UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostri... 145 2e-33 UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydro... 145 3e-33 UniRef50_A5ZAJ9 Putative uncharacterized protein n=1 Tax=Eubacte... 144 3e-33 UniRef50_Q0C254 D-isomer specific 2-hydroxyacid dehydrogenase fa... 144 3e-33 UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 T... 144 4e-33 UniRef50_A7IJ69 D-isomer specific 2-hydroxyacid dehydrogenase NA... 144 4e-33 UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinu... 144 6e-33 UniRef50_C8ZXV6 D-isomer specific 2-hydroxyacid dehydrogenase n=... 143 8e-33 UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehyd... 143 8e-33 UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 143 1e-32 UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Baci... 143 1e-32 UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, N... 142 1e-32 UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms... 142 2e-32 UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verru... 142 2e-32 UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verru... 141 3e-32 UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacte... 141 3e-32 UniRef50_B1SFW3 Putative uncharacterized protein n=1 Tax=Strepto... 141 4e-32 UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Stap... 140 5e-32 UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Fir... 140 5e-32 UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (cla... 140 5e-32 UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncul... 140 8e-32 UniRef50_Q03UK9 Lactate dehydrogenase n=5 Tax=Leuconostocaceae R... 140 9e-32 UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerot... 139 1e-31 UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerot... 139 1e-31 UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobil... 139 1e-31 UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostri... 138 3e-31 UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplasti... 138 3e-31 UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Ta... 138 3e-31 UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NA... 137 4e-31 UniRef50_C7RDP2 D-isomer specific 2-hydroxyacid dehydrogenase NA... 137 4e-31 UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halot... 137 5e-31 UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=... 137 6e-31 UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax... 137 7e-31 UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax... 137 7e-31 UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clost... 136 8e-31 UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staph... 136 1e-30 UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acido... 136 1e-30 UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces... 135 1e-30 UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales Re... 135 2e-30 UniRef50_A5F5E1 2-hydroxyacid dehydrogenase family protein n=44 ... 135 2e-30 UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID... 135 2e-30 UniRef50_UPI00016C4FF9 D-3-phosphoglycerate dehydrogenase n=2 Ta... 135 2e-30 UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntr... 135 2e-30 UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3... 135 2e-30 UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichop... 135 2e-30 UniRef50_A4EQ78 Dehydrogenase n=6 Tax=Bacteria RepID=A4EQ78_9RHOB 134 3e-30 UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepI... 134 3e-30 UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 134 3e-30 UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=... 134 3e-30 UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pl... 134 3e-30 UniRef50_Q7MHE8 Lactate dehydrogenase n=12 Tax=Proteobacteria Re... 134 4e-30 UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Ta... 134 4e-30 UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planc... 134 4e-30 UniRef50_B9ML91 D-isomer specific 2-hydroxyacid dehydrogenase NA... 134 5e-30 UniRef50_C6XUZ4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 134 5e-30 UniRef50_C2ESK5 NAD binding D-isomer specific 2-hydroxyacid dehy... 134 5e-30 UniRef50_A9BFL0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 134 6e-30 UniRef50_Q0SCM8 Phosphoglycerate dehydrogenase n=2 Tax=Rhodococc... 133 7e-30 UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Lepto... 133 7e-30 UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 133 7e-30 UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 133 8e-30 UniRef50_A6CXX0 Dehydrogenase n=1 Tax=Vibrio shilonii AK1 RepID=... 133 8e-30 UniRef50_B3E5B4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 133 9e-30 UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cell... 133 1e-29 UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 133 1e-29 UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 133 1e-29 UniRef50_Q9BLF6 D-lactate dehydrogenase n=1 Tax=Octopus vulgaris... 133 1e-29 UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 132 1e-29 UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms... 132 1e-29 UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 132 1e-29 UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostri... 132 1e-29 UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 132 2e-29 UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n... 131 3e-29 UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 131 3e-29 UniRef50_A7NGZ0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 131 3e-29 UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cel... 131 3e-29 UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovib... 131 4e-29 UniRef50_Q47W88 D-isomer specific 2-hydroxyacid dehydrogenase fa... 130 4e-29 UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Delta... 130 4e-29 UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicu... 130 5e-29 UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquif... 130 5e-29 UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 130 5e-29 UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 130 5e-29 UniRef50_D1YD83 Putative glyoxylate reductase n=3 Tax=Propioniba... 130 5e-29 UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 130 5e-29 UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 130 6e-29 UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostri... 130 7e-29 UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Ta... 130 7e-29 UniRef50_D1PIB3 Glycerate dehydrogenase n=2 Tax=Clostridiales Re... 130 8e-29 UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 130 8e-29 UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 130 8e-29 UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desu... 129 1e-28 UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fr... 129 1e-28 UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 129 1e-28 UniRef50_Q2HEY4 Putative uncharacterized protein n=4 Tax=cellula... 129 1e-28 UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organis... 129 1e-28 UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia... 129 1e-28 UniRef50_B2RGZ9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 129 2e-28 UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NA... 129 2e-28 UniRef50_B8J355 D-isomer specific 2-hydroxyacid dehydrogenase NA... 129 2e-28 UniRef50_UPI0001B416D9 D-3-phosphoglycerate dehydrogenase n=1 Ta... 129 2e-28 UniRef50_C6JFM4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Rumin... 129 2e-28 UniRef50_B9E2Y3 Putative uncharacterized protein n=2 Tax=Clostri... 129 2e-28 UniRef50_B4D576 D-isomer specific 2-hydroxyacid dehydrogenase NA... 129 2e-28 UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepI... 128 2e-28 UniRef50_Q2S4U0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 128 2e-28 UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 128 2e-28 UniRef50_Q14L30 Hypothetical d-lactate dehydrogenase protein n=1... 128 3e-28 UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 128 3e-28 UniRef50_B7ALT2 Putative uncharacterized protein n=1 Tax=Bactero... 128 3e-28 UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillale... 128 3e-28 UniRef50_A3ZW64 Phosphoglycerate dehydrogenase, putative n=1 Tax... 128 3e-28 UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobac... 127 4e-28 UniRef50_D2R987 D-isomer specific 2-hydroxyacid dehydrogenase NA... 127 4e-28 UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevo... 127 4e-28 UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria ... 127 4e-28 UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=... 127 4e-28 UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 127 4e-28 UniRef50_A1ZGW5 D-3-phosphoglycerate dehydrogenase n=1 Tax=Micro... 127 4e-28 UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacilla... 127 5e-28 UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 127 5e-28 UniRef50_A8RA71 Putative uncharacterized protein n=1 Tax=Eubacte... 127 6e-28 UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Ta... 127 7e-28 UniRef50_A9CLC8 D-isomer specific 2-hydroxyacid dehydrogenase, N... 127 7e-28 UniRef50_Q2YBY5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 126 9e-28 UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n... 126 9e-28 UniRef50_B1HNB2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Firmi... 126 1e-27 UniRef50_UPI0001B59B44 putative D-3-phosphoglycerate dehydrogena... 126 1e-27 UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Egger... 126 1e-27 UniRef50_C8Q2E6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 126 1e-27 UniRef50_B0TV60 D-isomer specific 2-hydroxyacid dehydrogenase NA... 126 1e-27 UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostri... 126 1e-27 UniRef50_A8HPR9 Predicted protein (Fragment) n=1 Tax=Chlamydomon... 125 2e-27 UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actin... 125 2e-27 UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostri... 125 2e-27 UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Acti... 125 2e-27 UniRef50_Q1CG62 D-isomer specific 2-hydroxyacid dehydrogenase fa... 125 2e-27 UniRef50_C0FP84 Putative uncharacterized protein n=2 Tax=Clostri... 125 3e-27 >UniRef50_P52643 D-lactate dehydrogenase n=152 Tax=Bacteria RepID=LDHD_ECOLI Length = 329 Score = 682 bits (1759), Expect = 0.0, Method: Compositional matrix adjust. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV Sbjct: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI Sbjct: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA Sbjct: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS Sbjct: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT Sbjct: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 AEALTSISQTTLQNLSNLEKGETCPNELV Sbjct: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 >UniRef50_P44501 2-hydroxyacid dehydrogenase homolog n=103 Tax=cellular organisms RepID=DDH_HAEIN Length = 331 Score = 503 bits (1296), Expect = e-141, Method: Compositional matrix adjust. Identities = 231/326 (70%), Positives = 278/326 (85%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A+YSTK YD+KY++ +N + F+LEFFDF+L E T + A CE VCIFVND+GSR V Sbjct: 1 MKIAIYSTKSYDRKYIELINAKYNFDLEFFDFMLNESTVRLAEHCEVVCIFVNDNGSRKV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L GVK +ALRCAGFNNVDL AA+ELG++VVRVPAY PEAVAEH IG+MMTLNRRI Sbjct: 61 LEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTLNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAYQRTR+ANFSLEGL GF MYG+T GVIGTGKIG+A++RILKGFGM +LA+DP+ + Sbjct: 121 HRAYQRTREANFSLEGLIGFNMYGRTVGVIGTGKIGIAVMRILKGFGMNILAYDPFKNPV 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ELG +YV+L L+++S VI+LHCP TPENYHLLN AF +MK+GVMIVNTSRG+LID+ Sbjct: 181 VEELGGQYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGVMIVNTSRGSLIDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QAAI+ALK +KIG+LGMDVYENERDLFFEDKSN+VIQDD+FRRLS+CHNVL TGHQAFLT Sbjct: 241 QAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQDDIFRRLSSCHNVLLTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPN 326 EALT+I+ TL N+ L+ G+ C N Sbjct: 301 EEALTNIADVTLSNIYKLKSGKVCEN 326 >UniRef50_Q8Z0N3 D-lactate dehydrogenase n=9 Tax=Bacteria RepID=Q8Z0N3_ANASP Length = 341 Score = 400 bits (1029), Expect = e-110, Method: Compositional matrix adjust. Identities = 188/328 (57%), Positives = 247/328 (75%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+STK YD+++L+ N EL FF+ L + TA A G AVC+FV+D Sbjct: 1 MKVAVFSTKAYDRQFLEAANAPKHHELAFFEPRLNQDTAILAAGFPAVCVFVHDQVDAAT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G + I LRCAGFNNVDL AA +LG+ VVRVPAY P VAEHA+G++++LNR+I Sbjct: 61 LEILASRGTRLIVLRCAGFNNVDLKAANKLGVTVVRVPAYSPYGVAEHAVGLILSLNRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY R R+ NF+L+GL GF + G+T G+IGTGKIG+ + +I+KGFG RLLA+D Y + Sbjct: 121 HRAYNRVREGNFALDGLLGFNINGRTVGIIGTGKIGLILGQIMKGFGCRLLAYDVYRNPE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG EYV+LP LF+ SD+ISLHCPL P+ +HL+N A EQ+K GVM++NTSRGALI + Sbjct: 181 MESLGGEYVELPELFANSDIISLHCPLMPQTHHLINAEAIEQVKPGVMLINTSRGALIHT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QA IE LK KIGSLG+DVYE E +LFFED S ++IQDD+F+RL+ NVL TGHQAF T Sbjct: 241 QAVIEGLKTGKIGSLGVDVYEQESELFFEDLSGEIIQDDIFQRLTTFPNVLITGHQAFFT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +AL +I++TTL N++++E+G +CPNE+ Sbjct: 301 EDALRNIAETTLNNIADIEQGRSCPNEI 328 >UniRef50_Q31F74 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=11 Tax=cellular organisms RepID=Q31F74_THICR Length = 352 Score = 384 bits (986), Expect = e-105, Method: Compositional matrix adjust. Identities = 179/328 (54%), Positives = 239/328 (72%), Gaps = 4/328 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A +S + DK + + +S E F + L+EKT G EA+C+FVNDD S V Sbjct: 19 MKVAFFSATKTDKNFFETNRQSDSLEFVFLEAHLSEKTVPLVQGVEAICVFVNDDLSEEV 78 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +L +GVK IALRCAGFNNVD++AA++ GL ++RVPAY P AVAEHA+ +MM+LNR+ Sbjct: 79 IRQLASYGVKLIALRCAGFNNVDIEAARQHGLTILRVPAYSPMAVAEHALALMMSLNRKT 138 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +RAY R RD NF+LEGL GF M+ KTAG++GTG+IG+ M RIL G G+ +L +DP+P+ Sbjct: 139 YRAYNRIRDGNFALEGLLGFDMFQKTAGIMGTGRIGLEMTRILTGLGLNVLVYDPFPNQQ 198 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+E G EYV L TL+ +SD+ISLH PL PE +H+++ A QMK GVM++NTSRGAL+D+ Sbjct: 199 AIEYGAEYVSLATLYQQSDIISLHMPLLPETHHIIDADAIAQMKPGVMLINTSRGALMDA 258 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I LK +KIG LG+DVYE E +LFFED S ++IQDD F RL + NVL TGHQAF T Sbjct: 259 DALIAGLKTEKIGYLGIDVYEQEENLFFEDHSEEIIQDDAFERLVSFPNVLITGHQAFFT 318 Query: 301 AEALTSISQTTLQNLSNLE----KGETC 324 EALT+I+QTT++N+ + + K E C Sbjct: 319 QEALTNITQTTIENILDYQQQKIKHERC 346 >UniRef50_B4SP29 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=cellular organisms RepID=B4SP29_STRM5 Length = 334 Score = 362 bits (930), Expect = 8e-99, Method: Compositional matrix adjust. Identities = 174/332 (52%), Positives = 228/332 (68%), Gaps = 5/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNE----SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 M++AV+S + YD+++L++ N+ GF +FD L TA A C AVC+FVND Sbjct: 1 MQIAVFSARPYDRRFLEEANQRDAAGDGFAFVYFDVALDVHTAALAQDCAAVCVFVNDRL 60 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 PVL L GV+ + LRCAGFNNVDL AAK L L V RVPAY PEAVAEHA+ ++MTL Sbjct: 61 DAPVLRALHALGVRAVLLRCAGFNNVDLAAAKALDLFVARVPAYSPEAVAEHALALVMTL 120 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 NR+ HRAY R R+ NF L+GL G T++G+T G++GTGKIG+A RI +G G +L DPY Sbjct: 121 NRQTHRAYNRVREGNFMLDGLLGRTLHGRTVGIVGTGKIGLATARIFRGMGCIVLGHDPY 180 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 PS+A +G E V L L + +D++SLHCPLTPE +HL+N+A+ +MK G M+VNTSRGA Sbjct: 181 PSSAFGGIG-EMVGLDELLARADIVSLHCPLTPETHHLINDASLARMKPGAMLVNTSRGA 239 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D+ A I ALK++++G L +DVYE E LFF+D S ++I D+ F+RL NVL TGHQ Sbjct: 240 LVDTHAVIRALKSRRLGHLAIDVYEQESALFFQDLSGEIIDDEAFQRLMTFPNVLVTGHQ 299 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T EAL IS TL NL + G C N + Sbjct: 300 GFFTVEALQEISAITLGNLQDFAAGRPCANRV 331 >UniRef50_C7QLW6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=19 Tax=cellular organisms RepID=C7QLW6_CYAP0 Length = 336 Score = 357 bits (917), Expect = 2e-97, Method: Compositional matrix adjust. Identities = 172/329 (52%), Positives = 233/329 (70%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S + YD+++L N + EL +F+ LL KTA A+G AVC+FVND+ Sbjct: 1 MKVAVFSAEAYDRQFLNAANANADHELVYFETLLEPKTASLAHGFPAVCVFVNDNLDPET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L G K +ALRC GFNNVD+ AA +LG+KVVRV Y P +VAE AIGM++ LNR+ Sbjct: 61 LKILADQGTKLVALRCTGFNNVDVTAAAQLGIKVVRVSVYSPYSVAEFAIGMILVLNRKF 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R RD NFSL GL GF ++G T GVIGTGKIG+ I+ GFG LL +D YP+ Sbjct: 121 HKAYNRVRDDNFSLNGLMGFDLHGCTVGVIGTGKIGLIFAEIMHGFGCHLLGYDLYPNPH 180 Query: 181 ALELG-VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + YVDL LF+ SD+ISLHCPLTPEN++L+N +MK GVM++NTSRG LID Sbjct: 181 FETMANAHYVDLSDLFTNSDIISLHCPLTPENHYLINTETIAKMKPGVMLINTSRGKLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++AAI+ +K+ +IGSLG+DVYE E +LFF D S+ +IQDD F+ L + NV+ T HQAFL Sbjct: 241 TKAAIKGIKSGQIGSLGIDVYEEEDNLFFRDLSDTIIQDDTFQLLQSFPNVVITAHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A++ I+ TT++++++ E+G T NE+ Sbjct: 301 TRNAISQIADTTIESITDFEQGNTLKNEI 329 >UniRef50_Q4K893 D-lactate dehydrogenase n=15 Tax=Gammaproteobacteria RepID=Q4K893_PSEF5 Length = 329 Score = 354 bits (908), Expect = 3e-96, Method: Compositional matrix adjust. Identities = 165/322 (51%), Positives = 227/322 (70%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ ++S++ YD++ G EL+F L+ TA A E VC F+NDD S PV Sbjct: 1 MRTILFSSQNYDRESFLGAQLPAGIELQFQAARLSLDTAALAERHEVVCAFINDDLSAPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L G + IALR AG+N+VDL AA+ LGL VVRVPAY P AVAEHA+ +++ LNRR+ Sbjct: 61 LEQLAAGGTRLIALRSAGYNHVDLSAAQRLGLDVVRVPAYSPHAVAEHAVALILALNRRL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTR+ +F+L GLTGF + GKT G++GTG+IG RI+ GFG +LLA+DP+P+ A Sbjct: 121 HRAYNRTREGDFTLHGLTGFDLVGKTVGIVGTGQIGATFARIMAGFGCQLLAYDPFPNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG Y+DLP L ++S +ISLHCPLT ++ +L+N+ + M+ G M++NT RG L+D+ Sbjct: 181 VEALGARYLDLPELLAQSQIISLHCPLTEDSRYLINQQSLAHMQPGAMLINTGRGGLVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEALK+ ++G LG+DVYE E LFFED+S+ +QDDV RL NV+ T HQAFLT Sbjct: 241 PALIEALKSGQLGYLGLDVYEEEAQLFFEDRSDLPLQDDVLARLLTFPNVIVTAHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGE 322 EAL +I++TTL N+++ G+ Sbjct: 301 REALAAIAETTLHNIASWAAGQ 322 >UniRef50_P30799 2-hydroxyacid dehydrogenase homolog n=7 Tax=Bacteria RepID=DDH_ZYMMO Length = 331 Score = 351 bits (900), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 166/331 (50%), Positives = 236/331 (71%), Gaps = 2/331 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A++S+K YD +++ NE +G +L F + LT++TA+ A EAVCIFVND+ + V Sbjct: 1 MRVAIFSSKNYDHHSIEKENEHYGHDLVFLNERLTKETAEKAKDAEAVCIFVNDEANAEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G+K +ALRCAG+NNVDLDAAK+L +KVVRVPAY P +VAE+A+GM++TLNR+I Sbjct: 61 LEILAGLGIKLVALRCAGYNNVDLDAAKKLNIKVVRVPAYSPYSVAEYAVGMLLTLNRQI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 R +R R+ NFSLEGL G ++ KT G+IG G IG I+ GFG ++A+ P+P Sbjct: 121 SRGLKRVRENNFSLEGLIGLDVHDKTVGIIGVGHIGSVFAHIMTHGFGANVIAYKPHPDP 180 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A ++G + L + SD+ISLHCPLTPEN+H++NE + K G +VNTSRG L+ Sbjct: 181 ELAKKVGFRFTSLDEVIETSDIISLHCPLTPENHHMINEETLARAKKGFYLVNTSRGGLV 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D++A I++LK + +G DVYE E LFFE+ ++D+I+DD+ RL A NV+FTGHQAF Sbjct: 241 DTKAVIKSLKAKHLGGYAADVYEEEGPLFFENHADDIIEDDILERLIAFPNVVFTGHQAF 300 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 LT EAL++I+ + LQ++S+ E G+ P+ LV Sbjct: 301 LTKEALSNIAHSILQDISDAEAGKEMPDALV 331 >UniRef50_D2LI76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LI76_RHOVA Length = 347 Score = 349 bits (896), Expect = 7e-95, Method: Compositional matrix adjust. Identities = 170/330 (51%), Positives = 226/330 (68%), Gaps = 1/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A +S + +L + N +G EL FF L+ +TA+ A G AVC FV D Sbjct: 1 MRIAFFSEHAFQTPFLIEANREYGHELVFFKEQLSRRTAQLAAGFVAVCPFVTDKLDAET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L G K IALR AGFNN+DL AA+ LGL V+RVPAY P A+AEHA+ +M+ LNRRI Sbjct: 61 LRILADGGTKLIALRSAGFNNLDLAAAERLGLCVMRVPAYAPTAIAEHAVALMLALNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + AY R R+ NFSL+ L GF M G+T G++GTGKIG ++ RI+ GFG +L +D Y + A Sbjct: 121 NHAYNRVREGNFSLDHLVGFNMEGRTVGIVGTGKIGESLARIMHGFGCHILGYDIYQNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + LG++YVDLPTL SESD++SLHCPLTPE HL+NE + MK G M++NT+RG L+++ Sbjct: 181 CIALGMKYVDLPTLLSESDIVSLHCPLTPETKHLINEETLKLMKPGSMLINTARGGLVNA 240 Query: 241 QAAIEALKNQK-IGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A IEALK + + +GMDVYE E LFF D S+ +IQDDVF L+ NV+ TGHQAFL Sbjct: 241 EAVIEALKRKDGLAYVGMDVYEREEGLFFSDHSSSIIQDDVFELLTTMRNVIVTGHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EAL I+ TTL N+++ E G P ++ Sbjct: 301 TREALAEIAHTTLGNVADYELGTPNPKNVL 330 >UniRef50_B6HIS7 Pc21g23650 protein n=11 Tax=cellular organisms RepID=B6HIS7_PENCW Length = 347 Score = 349 bits (896), Expect = 7e-95, Method: Compositional matrix adjust. Identities = 172/332 (51%), Positives = 222/332 (66%), Gaps = 4/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFEL---EFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 MKLAV+S K YD+ Y QV E EL E+ F L+E+T A GC+AVC+FVND Sbjct: 1 MKLAVFSAKSYDRTYFDQVREQHFPELCTIEYHAFALSEETVPLAQGCDAVCVFVNDTLD 60 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 VL L +G++ I LRCAGFN+V L+ A+ELGL V VPAY PEAVAE A+ ++ TLN Sbjct: 61 ERVLRALHAYGIRAILLRCAGFNHVHLETAEELGLFVANVPAYSPEAVAEFAVALIQTLN 120 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+ HRAY R R+ NF++EGL G T++GKT G+IG G+IG+A RI GFG RLLA DP+ Sbjct: 121 RKTHRAYNRVREGNFNIEGLLGNTLHGKTVGIIGVGRIGLAAARIFHGFGCRLLAHDPFA 180 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + G VDL TL ES ++SLHCPLT HL+NE +++ G ++VNTSRG L Sbjct: 181 GEEFRQFGT-LVDLDTLLQESHIVSLHCPLTDSTKHLINEETLARIRPGSLLVNTSRGGL 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID+ A I+ALK +++G L +DVYE E ++F+ D S ++I DDV RL HNVL GHQ Sbjct: 240 IDTAAVIQALKTKQLGGLALDVYEAEGEIFYNDHSGEIIDDDVLMRLMTFHNVLICGHQG 299 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 F T EAL I++ TL NLS+L +C N LV Sbjct: 300 FFTREALEEIAEVTLGNLSDLVSARSCKNSLV 331 >UniRef50_A9KHK7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KHK7_CLOPH Length = 346 Score = 343 bits (879), Expect = 7e-93, Method: Compositional matrix adjust. Identities = 170/328 (51%), Positives = 228/328 (69%), Gaps = 5/328 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +K+A + TK YDK++ + N F++++++ L TAK A+GC+AV FVND + Sbjct: 2 IKVACFDTKSYDKEWFDRKNNG-EFQIKYYENKLNADTAKLAHGCQAVIAFVNDSIDKET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +EEL + G+K IA+RCAG+NN+D A + + VVRVP Y P AVAEHA+ +++ LNR+I Sbjct: 61 IEELYQLGIKVIAMRCAGYNNIDFKEAYQ-KIAVVRVPGYSPHAVAEHAMALLLCLNRKI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTRD NFSL+GL GF +Y KT GV+GTGKIG + I KGFGMR+LA+D YP + Sbjct: 120 HRAYIRTRDYNFSLKGLIGFDLYKKTIGVVGTGKIGQVFIDICKGFGMRVLAYDLYPDHS 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +EYV L TLFSESDVISLHCPLT E+ H++N + MK +I+NTSRGALIDS Sbjct: 180 K---DIEYVSLETLFSESDVISLHCPLTEESKHMINAETLKLMKQDAVIINTSRGALIDS 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A + ALK ++I G+DVYE E DLFFED S + +DDV L NV+ T HQ FLT Sbjct: 237 EALLVALKEERIAGAGLDVYEEESDLFFEDNSGTIPKDDVLSLLVGLPNVIITSHQGFLT 296 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL++I++TT++NL E+ NE+ Sbjct: 297 NEALSNIAETTIENLRAYFHDESLINEI 324 >UniRef50_UPI0001AEC4CE D-lactate dehydrogenase n=1 Tax=Alteromonas macleodii ATCC 27126 RepID=UPI0001AEC4CE Length = 346 Score = 342 bits (878), Expect = 8e-93, Method: Compositional matrix adjust. Identities = 160/319 (50%), Positives = 220/319 (68%), Gaps = 6/319 (1%) Query: 3 LAVYSTKQYDKKYLQQVNESFG------FELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 +A +ST+ Y+ ++ E+ FF+ L TA + +G V +FVNDD Sbjct: 21 IAFFSTRSYEHALFSELLETLNGASDKTINATFFEHPLNASTAASCSGFSDVVVFVNDDI 80 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R +E LK GVK+IALRCAGFNNVD+DAA + G+ V RVPAY PE VAEH I +++TL Sbjct: 81 NRKTIEALKLCGVKHIALRCAGFNNVDVDAAAKAGITVSRVPAYSPETVAEHTIALILTL 140 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 NR+ H+AY R R+ NF+L GL GFT++GKT GVIGTGKIG A++RIL GFG +L FDP+ Sbjct: 141 NRKTHKAYNRVREGNFNLGGLMGFTLHGKTVGVIGTGKIGQAVIRILLGFGCHVLCFDPH 200 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 P+ +G YV L L +S +++LHCPL +++H++N + ++M GVM++NTSRG Sbjct: 201 PNNDVTTMGAHYVTLNELLEKSVIVTLHCPLNEQSHHIINAKSIDKMPQGVMLINTSRGG 260 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D A I+ LK++KIG LG+DVYE E +LFF D S D+IQDD+F+RL+ NVL TGHQ Sbjct: 261 LVDDNAIIKGLKSKKIGYLGLDVYERESELFFNDHSQDIIQDDIFQRLTTFPNVLITGHQ 320 Query: 297 AFLTAEALTSISQTTLQNL 315 F T EAL I++ T+ N+ Sbjct: 321 GFFTLEALEEIAKITVNNI 339 >UniRef50_B2JFX7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=cellular organisms RepID=B2JFX7_BURP8 Length = 335 Score = 338 bits (866), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 167/322 (51%), Positives = 217/322 (67%), Gaps = 1/322 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++S++QYD + N +FG+EL F + L TA A G + VC FVND Sbjct: 1 MRMMLFSSRQYDIDTFTEANAAFGYELHFQESHLDADTAVLAEGYDVVCPFVNDSVDAAT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G + IALR AGFN+VDL AA+ LG+ VVRVPAY P AVAEHA+G+++ LNR++ Sbjct: 61 LEALHAGGARLIALRSAGFNHVDLAAAQRLGIGVVRVPAYSPYAVAEHAVGLILALNRKL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA RTR+ +FSL GL GF ++GKT GVIGTG IG RI+ GFGM++LA DP P A Sbjct: 121 ARAVARTREGDFSLNGLLGFDLHGKTVGVIGTGIIGRCFGRIMAGFGMQVLAHDPGPPAT 180 Query: 181 A-LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 L LG YV L TL ++SD++SLHCPL P YHL++ A +MK G M++NT RG L++ Sbjct: 181 ELLALGGRYVPLDTLLADSDIVSLHCPLLPSTYHLIDSHALAKMKRGAMLINTGRGGLVE 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S A + ALK+ ++G LG+DVYE E +FFED SN +QDDV RL NV+ T HQAF Sbjct: 241 SNALVGALKSGQLGHLGLDVYEEEGGIFFEDHSNLPLQDDVLARLLMFPNVIVTAHQAFF 300 Query: 300 TAEALTSISQTTLQNLSNLEKG 321 T EA+T I+QTTL N+ G Sbjct: 301 TREAMTEIAQTTLGNVEAWRDG 322 >UniRef50_B7KQC7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Methylobacterium extorquens group RepID=B7KQC7_METC4 Length = 335 Score = 332 bits (850), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 161/328 (49%), Positives = 224/328 (68%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++AV+S K Y++ L +N +L +FD LL TA A G AV +FVND +R V Sbjct: 1 MRVAVFSAKNYERALLDDLNVGQEHDLTYFDALLEPGTASLAAGFTAVSVFVNDSVNRDV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L +L + G K +A RC GFN++DL+AA+E G++VVRV Y P +VAE A+G+++ LNR++ Sbjct: 61 LRQLAQGGTKLVATRCTGFNHIDLEAAEEFGIRVVRVVNYSPNSVAEFAVGLLLALNRKV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTR+ NF L+GL GF + +T VIGTGKIG RI+ GFG R++ FD + S Sbjct: 121 HRAYNRTREGNFRLDGLMGFDLVDRTVAVIGTGKIGTIFGRIMAGFGCRVIGFDVHRSPE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +G YVD + E+DVIS+HCPLTPE YH+++ ++K G +++NTSRG LID+ Sbjct: 181 FERIGGRYVDAAGV-EEADVISMHCPLTPETYHIVDARTLGRVKKGALLINTSRGGLIDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AAI+ALK+ ++G L +DVYE E +LF+ D S+ VI DDV +RL + NV+ TGHQAF T Sbjct: 240 DAAIDALKSGRLGGLAIDVYEQEAELFYRDLSSTVIPDDVIQRLISFPNVIVTGHQAFFT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL +I TTL+++S LE G NE+ Sbjct: 300 QEALETILGTTLKSISELEAGHPLTNEV 327 >UniRef50_C0A4H0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Opitutaceae bacterium TAV2 RepID=C0A4H0_9BACT Length = 345 Score = 331 bits (849), Expect = 2e-89, Method: Compositional matrix adjust. Identities = 160/328 (48%), Positives = 217/328 (66%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S+K YD+++ N +L +F+ LT +TA A+G EAVC FVND Sbjct: 1 MKIAVFSSKSYDRRFFDAANTLHRHQLSYFEARLTRETAPLAHGFEAVCAFVNDRLDSGA 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L + GV + LR AG+N+ DL+AA +L + V VP Y P +VAEHA +M+ LNRRI Sbjct: 61 LARLSEAGVNLLLLRSAGYNHADLEAAADLNIVVTHVPNYSPHSVAEHAAALMLALNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A+ R R+ NFS+EGL GF M+GKTAG+IG G IG RIL+GFG ++LA+DP PS Sbjct: 121 PHAFVRVREGNFSIEGLLGFDMHGKTAGLIGAGHIGAITGRILQGFGCKVLAYDPAPSEQ 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+ E+ L + S SD++SLHCPLTP HL+ K G M++NTSRG LID+ Sbjct: 181 AVAANFEFGMLEDVISASDIVSLHCPLTPSTRHLIGRLTLPWFKRGAMLINTSRGGLIDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A IE+L+N +GSLG+DVYE+E ++FFED S + DDVF RL A NVL TGHQ F T Sbjct: 241 RAVIESLENGLLGSLGIDVYEDEAEIFFEDHSRQGLGDDVFSRLIAMPNVLVTGHQGFFT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA+ +I++T+L+ ++ G TC + L Sbjct: 301 EEAMQTIAETSLKAATDFAAGRTCAHVL 328 >UniRef50_B9ZMK9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZMK9_9GAMM Length = 331 Score = 325 bits (834), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 157/320 (49%), Positives = 218/320 (68%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S +Q+D ++L + G E + LTE+T A G +AVC+F NDD R V Sbjct: 1 MKVAVFSIQQHDHEHLVPGLTAAGMEPVVYAERLTEETIHLAAGVDAVCVFTNDDLKRGV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ L G++ IALRC+G++N+D+ A+E G++V RVPAY P AVAEHA+ +++TLNR + Sbjct: 61 IDGLADQGIQVIALRCSGYDNLDVGRARERGVRVGRVPAYSPNAVAEHAVALLLTLNRSV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRA+ RTR +F L+ LTGF + G+T GV+GTG+IG RI+ GFG R+LA DPYP+A Sbjct: 121 HRAWDRTRRGDFRLDHLTGFDLVGRTVGVVGTGRIGQVFARIMLGFGCRVLAHDPYPNAE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +GVEY DL TL +ES V+SL CP+TPEN H++N +M G ++NT+RGAL+D+ Sbjct: 181 LQAVGVEYRDLDTLLAESSVVSLSCPMTPENRHMINADTLARMPRGAFLINTARGALVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AA AL + ++G +DVYE E LFF D S + D RL +VL TGHQAFLT Sbjct: 241 DAAEIALDSGQLGGFALDVYEAEAGLFFRDWSLAGLPDRRLARLMQRDDVLVTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEK 320 EALT+I+ TT+ NL+ L + Sbjct: 301 HEALTNIADTTVSNLTTLHQ 320 >UniRef50_Q22CX9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain containing protein n=3 Tax=cellular organisms RepID=Q22CX9_TETTH Length = 359 Score = 323 bits (828), Expect = 5e-87, Method: Compositional matrix adjust. Identities = 155/330 (46%), Positives = 217/330 (65%), Gaps = 5/330 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFE----LEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 ++AV+S K+YD K+ Q+NE E ++F+ L EKTA G + +C FVND + Sbjct: 23 RVAVFSAKKYDIKFFNQINEKLPIEKRIIFDYFEEELNEKTAILTQGYDVICPFVNDKLN 82 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 +P ++ L K+G+ IALRCAGFNN DL+ A++ +KVVRVPAY P AVAEH + ++++L Sbjct: 83 QPTIQTLAKNGIDLIALRCAGFNNTDLECAQKNNIKVVRVPAYSPHAVAEHTMALLLSLV 142 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+IH+AY RT+D NFSL+GL GF +Y K G+ GTGKIG + I +GFGM +L DPYP Sbjct: 143 RKIHKAYNRTKDGNFSLDGLLGFDLYKKKIGIFGTGKIGQTFMGICQGFGMEILCHDPYP 202 Query: 178 SAAAL-ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + + + YVD TLF E D+ISLHCPLT ++++ + MK G +I+NT RG Sbjct: 203 NEEVVKKYNARYVDQATLFKECDIISLHCPLTFSTQYVIDRKTIDIMKKGAIIINTGRGK 262 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+ + I ALK+ ++G + +DVYE+E FF+D S DVI DD RL NV+ T HQ Sbjct: 263 LMRTDEVIAALKSGQLGGVALDVYEHEEGYFFKDVSADVIYDDDLARLLMYPNVIVTSHQ 322 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPN 326 AF T EA+T+I QTT+ N+ ++ E C N Sbjct: 323 AFFTQEAITAICQTTIDNILKIKANEPCDN 352 >UniRef50_Q54UF7 Putative D-lactate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=LDHD_DICDI Length = 340 Score = 313 bits (803), Expect = 4e-84, Method: Compositional matrix adjust. Identities = 149/331 (45%), Positives = 220/331 (66%), Gaps = 3/331 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ ++S+K Y K+ ++N+ F +E+ + K+ A G EAVC FVNDD S+ V Sbjct: 1 MKITLFSSKPYWVKWFNELNK-FSYEINYVTSACDIKSVNEAKGSEAVCCFVNDDLSKEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E L +G K I +RCAGFN VDLD A +LG+ V+RVPAY P AV+E+A+ ++M LNR+ Sbjct: 60 IETLHSNGTKVILMRCAGFNKVDLDTANKLGIPVLRVPAYSPNAVSEYALSLIMALNRKT 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 H+A+ R RDANF + G+ GF M K G++GTG IG + R+LK GFG +++A+D + Sbjct: 120 HKAHDRVRDANFEINGMEGFNMVSKVYGIVGTGNIGEQLCRVLKLGFGAKVIAYDIIENK 179 Query: 180 AALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A ++G+EYV L ++ + DVISLH PL + +++N + E+M++GVMI+N SRGAL+ Sbjct: 180 AVTDIGIEYVKTLDEIWKQCDVISLHTPLNSQTKYMVNSESIEKMRDGVMIINVSRGALV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ AI LK+ KI SLGMDVYENE D F++D + +I+DD L + NV+ T HQA+ Sbjct: 240 NASDAIVGLKSGKISSLGMDVYENETDYFYQDHNGSIIKDDNLSLLISYPNVMITSHQAW 299 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EA++ I T+LQN + + + LV Sbjct: 300 YTKEAISCICGTSLQNFVDFRSNQIKKSNLV 330 >UniRef50_A0Q8P3 D-isomer specific 2-hydroxyacid dehydrogenase n=5 Tax=Francisella novicida RepID=A0Q8P3_FRATN Length = 327 Score = 312 bits (799), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 163/327 (49%), Positives = 225/327 (68%), Gaps = 3/327 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ YSTK+YDK Y N +LEF ++ L ++TA A G +AVCIFVND V Sbjct: 1 MKILFYSTKKYDKTYFTAENNQH--DLEFKEYGLNQQTADFAKGYDAVCIFVNDICDADV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++L GV+ + LRCAGFNNVD+D AK+L +KV RVPAY P +VAEH + +++ LNR+I Sbjct: 59 LDKLYSLGVRAVLLRCAGFNNVDIDHAKKLDIKVARVPAYSPFSVAEHTLALLLCLNRKI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R +++NF++EGL GF ++ KT G+IG G IG A +I GFG +L +DPY A Sbjct: 119 HKAYNRVKESNFNIEGLEGFDVHRKTIGIIGFGNIGKAFAQICSGFGGEILVYDPYADRA 178 Query: 181 ALELGVEYVDLPT-LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V +VD LF+E+D+ISLHCPL + ++++E A + +K I+NTSRGALID Sbjct: 179 IAPSYVTFVDDKNKLFAEADIISLHCPLNADTKYIIDEKALQIIKPSTFIINTSRGALID 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +QA I++LK++ I +L +DVYE E+DLFF+D S ++I DD+F RL NVL T HQAFL Sbjct: 239 TQAIIKSLKSKSIAALAIDVYEYEKDLFFKDMSGEIINDDLFERLLTFPNVLVTAHQAFL 298 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPN 326 T EAL I+ TTL N S +E+ ++ N Sbjct: 299 TKEALEGIATTTLDNASMIEQSKSSDN 325 >UniRef50_B5EQZ7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Bacteria RepID=B5EQZ7_ACIF5 Length = 331 Score = 310 bits (795), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 161/326 (49%), Positives = 218/326 (66%), Gaps = 1/326 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ V S + YD+++L N EL F + L+ TA A G A+C FV+D Sbjct: 1 MRCLVTSARPYDEQFLSAANHG-RHELVFVETALSADTAFIAQGYPAICPFVDDTLDAKT 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE + + G K + LR GFN+VD+ AA++ G+ V+RV Y P AVAE+A+G+M+TLNR + Sbjct: 60 LETIARLGTKLLVLRSTGFNHVDMPAAEKYGITVMRVRDYSPYAVAEYAVGLMLTLNRHL 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R RD NF L+GL GF M+GKT G+IGTGKIG A+ RIL G G LL +D + A Sbjct: 120 HKAYNRVRDGNFLLDGLLGFDMHGKTVGIIGTGKIGQALARILHGMGCHLLGYDTVANPA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LELGV YV L L +S ++SLH PL PE HL+N F M +G M++NTSRG LID+ Sbjct: 180 CLELGVAYVPLEELLVKSQIVSLHVPLLPETRHLMNAERFALMPDGAMLINTSRGPLIDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I ALK++ +G++G+DVYE E +L+F+D +D+I DD F RL NV+ TGHQAF T Sbjct: 240 TALIAALKSRHLGAVGLDVYEEEAELYFKDHCDDIICDDSFERLLTFPNVIITGHQAFFT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPN 326 +EALT+I++TT+QNL + G+ PN Sbjct: 300 SEALTTIARTTIQNLDDYSDGKDNPN 325 >UniRef50_A8SQC5 Putative uncharacterized protein n=4 Tax=Clostridiales RepID=A8SQC5_9FIRM Length = 343 Score = 308 bits (789), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 155/331 (46%), Positives = 219/331 (66%), Gaps = 5/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M + Y TK+YD+ + + +++ + L+ +TA+ A G EA+C FV+ D S Sbjct: 14 MNILFYDTKKYDRDSFDAIKGGYPQLCIDYVEADLSVRTARLARGYEAICAFVSSDVSAA 73 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V+ L + GVK I +RCAGFNNVDLDA ++ G+ V+RVP Y PEAVAEHA+ + M +NR+ Sbjct: 74 VVNALSEVGVKLILMRCAGFNNVDLDATEKCGMTVLRVPGYSPEAVAEHAMALAMAVNRK 133 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +H++Y + R+ NFSL GLTG +GK AG++GTGKIG AM RI GFGM+++A+D Y + Sbjct: 134 LHKSYIKVRENNFSLVGLTGMNFHGKIAGIVGTGKIGAAMARICHGFGMKVIAYDMYKNP 193 Query: 180 AALELG-VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 EL V YV+L LF SD+ISLHCPLT + YHL+N QMK+ V++VNTSRGALI Sbjct: 194 ---ELDFVTYVELQELFRVSDLISLHCPLTDDTYHLVNADTIAQMKDKVILVNTSRGALI 250 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ I ++++K +G+DVYE E FE++ +D+++ + RL + NV+ T HQ F Sbjct: 251 KTEDLIAGIRSRKFFGVGLDVYEEETGNVFENREDDILETSITARLLSFPNVIVTSHQGF 310 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 LT EAL +IS+TTL N N E G LV Sbjct: 311 LTEEALEAISRTTLDNAVNFEAGNIDKANLV 341 >UniRef50_Q9P7Q1 2-hydroxyacid dehydrogenase homolog 2 n=2 Tax=Schizosaccharomyces pombe RepID=DDH2_SCHPO Length = 332 Score = 302 bits (774), Expect = 1e-80, Method: Compositional matrix adjust. Identities = 143/319 (44%), Positives = 214/319 (67%), Gaps = 1/319 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++S++ YD+ ++ N++F E+ + +F L + T A + VC+FVND Sbjct: 1 MRVVLFSSQSYDRGPFEEANKTFNHEIIYHNFSLNKDTVSLAGKAQVVCVFVNDQVDADT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L ++GVK +ALRC G+NNV+L AA E + VV VP+Y P AV+E +G++++LNR+I Sbjct: 61 LKALAENGVKLVALRCGGYNNVNLKAASEYKITVVHVPSYSPFAVSEFTVGLLLSLNRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 HRAY R R+ +F++ GL G ++GKT GVIGTGKIG + + K GFG +LA+D P Sbjct: 121 HRAYVRVREDDFNIVGLLGCDIHGKTVGVIGTGKIGSNVAKCFKMGFGCDVLAYDINPDK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 GV++V+ + ++D + LHCPLTP H++N + MK GV IVNTSRG LID Sbjct: 181 KLENYGVQFVEQNEVLKKADFLCLHCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A ++A+ + ++G +DVYE ER+LF++D SN+VI+D F+RL NVL T HQAF Sbjct: 241 TKALVDAIDSGQVGGCAIDVYEGERNLFYKDLSNEVIKDSTFQRLVNFPNVLVTSHQAFF 300 Query: 300 TAEALTSISQTTLQNLSNL 318 T EAL SI+ TTL++ S+ Sbjct: 301 TTEALCSIAHTTLKSASDF 319 >UniRef50_C5K2M9 D-lactate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5K2M9_AJEDS Length = 392 Score = 299 bits (765), Expect = 9e-80, Method: Compositional matrix adjust. Identities = 153/330 (46%), Positives = 214/330 (64%), Gaps = 1/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S ++Y++ L++ N+ F +EL +F L+ +T A G AV FV+D V Sbjct: 59 MKVAVFSFQEYERTALERFNQRFQYELVYFSAPLSTETVSLAAGSVAVSTFVSDHVDAEV 118 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G+K +ALRCAG ++VDL AA E + V+RVPAY A+AE+ IG+++TLNR I Sbjct: 119 LEVLADAGIKLVALRCAGHDSVDLQAASENHITVMRVPAYSSYAIAEYTIGILLTLNRNI 178 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 H+A R R NF L GL G +YGKT G+IGTG+IG A+ LK GFG R++A D Sbjct: 179 HKASTRVRTGNFDLNGLVGSNIYGKTVGIIGTGRIGAAVATTLKLGFGCRVIANDLDAHL 238 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++GV+YVD TLF SD I LHCPLT + H++N + + MK V++VNTSRG LID Sbjct: 239 ELEKIGVDYVDQDTLFRSSDFICLHCPLTKQTRHIINPESLQLMKPEVILVNTSRGGLID 298 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A +++L+N +I +DVYE E L F+ S + I D +RL + NV+ TGHQAFL Sbjct: 299 TPALLDSLENGRIRGCALDVYERENSLLFQKSSMEEIDDPTLKRLVSLPNVILTGHQAFL 358 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EA+ +I++TTL+N+ N G+ N V Sbjct: 359 TQEAIDAIAETTLKNIQNFLAGKVDVNRAV 388 >UniRef50_D2W085 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W085_NAEGR Length = 388 Score = 296 bits (759), Expect = 5e-79, Method: Compositional matrix adjust. Identities = 154/318 (48%), Positives = 216/318 (67%), Gaps = 5/318 (1%) Query: 7 STKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK- 65 S Y Y + ++ S F L+F D LTE T + A + V +FVND +R VL+ L Sbjct: 59 SPYDYLPNYERFMSYSGPFHLKFVDARLTESTVELAEHSDFVSVFVNDCLNRNVLQTLSH 118 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 K+G+K +ALR AGFNNVDL AA E G+KV RVP Y P A A+ I ++M LNR+IH+A+ Sbjct: 119 KYGIKCVALRSAGFNNVDLSAASEFGVKVCRVPEYSPAATADFTIALIMALNRKIHKAFN 178 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVI-GTGKIGVAMLRILK-GFGMRLLAFDPYPSAAALE 183 R RD++FSL+GL GF M K G++ G+GKIG + + L+ GFG R++ +D Y + Sbjct: 179 RLRDSDFSLDGLMGFNMSSKVFGIVGGSGKIGKLVAKCLRMGFGARVIVYDSYRDPELVN 238 Query: 184 LGVEYVD-LPTLFSESDVISLHCPLTPE-NYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +G+E+VD + ++++ SDVI LHCPL HL+N + +MK+GVMI+NTSRG L + Sbjct: 239 MGIEFVDNIDSIYAHSDVICLHCPLIKGVTEHLINSESISKMKDGVMIINTSRGGLCRTD 298 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 IE LK+QKIGSLG+DVYE E+DLFFED+ ++I+DD F RL NV+ T HQAF T Sbjct: 299 DLIEGLKSQKIGSLGIDVYEFEQDLFFEDRRFEIIKDDTFTRLLTFPNVIVTPHQAFFTQ 358 Query: 302 EALTSISQTTLQNLSNLE 319 EA+++I+QTTL++L + + Sbjct: 359 EAISNIAQTTLESLYSFD 376 >UniRef50_C9KNY1 D-lactate dehydrogenase n=2 Tax=Clostridiales RepID=C9KNY1_9FIRM Length = 432 Score = 296 bits (758), Expect = 8e-79, Method: Compositional matrix adjust. Identities = 151/334 (45%), Positives = 211/334 (63%), Gaps = 11/334 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNE-----SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDD 55 +K+A + TK YD+ Y ++ + ++ EL++F LT++TA ANG +AVCIFVND+ Sbjct: 94 LKVAFFGTKDYDRLYFSELAKDRGEGTYNVELKYFASRLTDETAHLANGYDAVCIFVNDE 153 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 R V+E+L GV+ I LRCAGFNNVD AA E G+ V+RVPAY P AVAEHA+ + Sbjct: 154 APRSVIEQLHDGGVRLILLRCAGFNNVDKKAAAEYGITVLRVPAYSPYAVAEHAMATLQA 213 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 NRR+H+AY + RD NF L GL G ++ K AG++GTG+IG M RI KG+GM ++ +D Sbjct: 214 ANRRLHKAYNKVRDNNFDLTGLLGVDLHNKVAGILGTGRIGQCMARICKGYGMTVIGWDA 273 Query: 176 YPSAAALELG-VEYVDLPTLFSESDVISLHCPLT---PENYHLLNEAAFEQMKNGVMIVN 231 +P+ E G + Y + S SD+IS+H PL YHL++E A MK+ VM+ N Sbjct: 274 FPNKKLEEEGLLTYASKEEVLSRSDLISIHAPLIMGEGGTYHLIDEKAISLMKDDVMLTN 333 Query: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVL 291 +RG LID++A I ALK K ++ +DVYE E + D S+DV +D+ RL V+ Sbjct: 334 AARGGLIDTEALIAALKKGKFHAVALDVYEGEDANVYTDHSSDVPTEDITGRLLMFPQVI 393 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 T HQAF T EAL +I+ T++N N +G CP Sbjct: 394 LTSHQAFFTREALQAIATVTMENARNFNEG--CP 425 >UniRef50_C1DZN2 D-Lactate dehydrogenase n=2 Tax=Micromonas RepID=C1DZN2_9CHLO Length = 339 Score = 293 bits (751), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 148/309 (47%), Positives = 198/309 (64%), Gaps = 12/309 (3%) Query: 19 VNESFGF-ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCA 77 + E+FG + + D LT +TA A GC A C+FVND ++ L GV++IA+RCA Sbjct: 9 IEEAFGAGNVRWLDVGLTPQTAPLAAGCNATCLFVNDRADAETIDALADLGVRFIAMRCA 68 Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 GF+ VDLDA G+ V RVPAY P A+AEHAI MM+ LNR++ + + R N+SL GL Sbjct: 69 GFDRVDLDACARRGVAVTRVPAYSPYAIAEHAIAMMLALNRQLMKGHARVVQGNYSLSGL 128 Query: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVD-LPTLFS 196 GF M+GKT G++GTGKIG +IL G G +LA+D + S A+ +GV+YVD + L Sbjct: 129 VGFDMHGKTVGIVGTGKIGRCTAKILLGMGCEVLAYDVFQSKEAIAMGVKYVDTVQELLP 188 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 ++SLHCPLT + YHL+++A F M+ G M+VNTSRG L+D+ A AL QKI + Sbjct: 189 RCQIVSLHCPLTDDTYHLMDDATFNLMRKGSMLVNTSRGGLVDTAALARALDAQKIACVA 248 Query: 257 MDVYENERDLFFEDKSNDV----------IQDDVFRRLSACHNVLFTGHQAFLTAEALTS 306 MDVYE+E LFFEDKS + D L++ NVL T HQAFLTAEAL + Sbjct: 249 MDVYEHEAGLFFEDKSEETDATPGSSLSPDWDLSLGSLASRPNVLVTSHQAFLTAEALGN 308 Query: 307 ISQTTLQNL 315 I+ TT++NL Sbjct: 309 IASTTVENL 317 >UniRef50_C8W7M7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Bacteria RepID=C8W7M7_ATOPD Length = 334 Score = 290 bits (743), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 154/332 (46%), Positives = 212/332 (63%), Gaps = 19/332 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFEL--------EFFDFLLTEKTAKTANGCEAVCIFV 52 MK+ Y + YDK +SF EL ++ + LT TA A G +AVC FV Sbjct: 1 MKILFYGAQSYDK-------DSFNLELPKYPDVSIDYIESNLTPMTAGFAKGYDAVCAFV 53 Query: 53 NDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGM 112 N D S LE L VK + +RCAGF+ VD++AAK+LG+ V RVPAY PEA+AEHA+G+ Sbjct: 54 NADASILTLEILAGFDVKLLLMRCAGFDAVDVNAAKDLGITVTRVPAYSPEAIAEHAMGL 113 Query: 113 MMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 + NRRIHR Y R R+ NFSL GL G T++GKTAG++GTG+IG A+ RI KGFGM +L Sbjct: 114 ALAANRRIHRGYNRIRENNFSLVGLVGETLHGKTAGIVGTGRIGAALCRICKGFGMHVLG 173 Query: 173 FDPYPSAAAL---ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMI 229 D YP+ + + + EYV L+ +D ISLH L E+YH++N+ +MK+GV++ Sbjct: 174 ADLYPNMSLVNDEHVVDEYVSYDELWERADFISLHAFLNEESYHMINDKTIGKMKDGVVL 233 Query: 230 VNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHN 289 VNT+RGAL+D++A I + + KIG+ G+DVYE E ++D++ +V D V L + N Sbjct: 234 VNTARGALVDTKALIRGILSGKIGACGLDVYEEENPNVYKDRAAEVF-DSVTSTLCSFPN 292 Query: 290 VLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 V+ T HQAF T EAL+ I+Q TL N + KG Sbjct: 293 VVMTSHQAFFTHEALSQIAQVTLDNATAFAKG 324 >UniRef50_A8UL50 D-lactate dehydrogenase n=2 Tax=unclassified Flavobacteriales (miscellaneous) RepID=A8UL50_9FLAO Length = 351 Score = 286 bits (731), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 142/329 (43%), Positives = 215/329 (65%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ VYS K ++ Y+++ N+ +++F L+ +TA A G EA+ IF D+ Sbjct: 17 MKVLVYSAKDFEIPYIEEANKR-KHKIDFTKDALSSETAMKAIGYEAISIFSADEACFIT 75 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+LK GVKYI LR G++N++L AA LG++V VPAY P A+AEH++ +++ LNR++ Sbjct: 76 IEKLKDFGVKYITLRSVGYDNINLRAASRLGIRVANVPAYSPYAIAEHSVALLLALNRKL 135 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + R NF+L L GF + KT G++GTGKIG M +I+ GFG +LL +D + Sbjct: 136 IESNFRVNHYNFNLNNLVGFDLNDKTVGIVGTGKIGAIMCKIMHGFGCKLLGYDIEENNT 195 Query: 181 ALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E + Y L L ++D+ISLH PL E + L+NE MK+GV+++NT+RG++++ Sbjct: 196 LKEYYNITYTSLKALCKQADIISLHVPLNTETHQLINEDLISFMKDGVILINTARGSVVN 255 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ I+ LKN KIG+LGMDVYENE+ +FF+D+S ++ DD+ +L+A NVL TGH AFL Sbjct: 256 TEDVIQGLKNGKIGALGMDVYENEKGVFFKDRSQNLPNDDLLLKLNAMPNVLITGHHAFL 315 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EALT+I++TT+ NL + NEL Sbjct: 316 TEEALTNIAETTIYNLDCWNLRKETENEL 344 >UniRef50_Q11QU3 D-lactate dehydrogenase n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11QU3_CYTH3 Length = 329 Score = 280 bits (717), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 153/329 (46%), Positives = 209/329 (63%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ YS + YDKK+ + N F E+ + L+ +TA A G AVCIFVNDD PV Sbjct: 1 MKILFYSARSYDKKHFEAANPG-TFTFEYIEEALSIETAHYAEGAFAVCIFVNDDACAPV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L +GVK IA+R AG + + AA LG+ V VPAY P A+AEH + M++ L R I Sbjct: 60 LEKLASYGVKGIAIRAAGHDQTNHVAAHRLGMHVANVPAYSPHAIAEHTVTMILALTRHI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A R + +NF L+ L GF ++ KT G+IG GKIG +IL GFG L AFDPYP+ Sbjct: 120 VEADNRVKQSNFILDPLVGFNIHHKTVGIIGLGKIGGLTAKILHGFGCTLQAFDPYPNQE 179 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + G++Y + + + SD+I +H PL +L++ + + MK+GVMIVNT RGA+I+ Sbjct: 180 YTDKYGLQYKSIEEVLATSDIIVIHAPLNAHTKYLIHADSIKTMKDGVMIVNTGRGAIIN 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ AI+ L + KIG LG+DVYENE+ LFF D S + D+VF L+ NVL TGH AFL Sbjct: 240 TKDAIDGLTSGKIGYLGLDVYENEKGLFFSDHSVNKPTDEVFLALTKFKNVLITGHMAFL 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T ALTSI+QTTL+NL G+ +E+ Sbjct: 300 TTNALTSIAQTTLENLRAWSNGKDADHEI 328 >UniRef50_Q89388 A53R protein n=3 Tax=Chlorovirus RepID=Q89388_PBCV1 Length = 363 Score = 278 bits (710), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 145/334 (43%), Positives = 211/334 (63%), Gaps = 8/334 (2%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 ++A++S Y K +++ + ES + + + L E TA AN C+A+ FVNDD S PVL Sbjct: 31 QVAIFSAGNYVKDFIKPI-ESICTPV-YIESSLNETTAALANKCDAINAFVNDDLSAPVL 88 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + LK GV I LRCAGF+ +D++ AKELG V RVPAY P +VAE A+ MM L+R I Sbjct: 89 DILKNCGVSSITLRCAGFDRLDIEYAKELGFNVYRVPAYSPRSVAELALTHMMALSRNIQ 148 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 R + N+++EGL G + KT G+IGTGKI ++++K R++A+D Y + Sbjct: 149 LVLPRVKTGNYTMEGLVGREITDKTIGIIGTGKIAQEFIKLVKPMAGRIIAYDVYENDIV 208 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 E+GVEY+ LP + ESDV+SLHCPL +H++NE + MK +I+NT+RG LID++ Sbjct: 209 KEMGVEYMSLPDVIKESDVLSLHCPLMKSTFHMINEDTLKTMKKTAVIINTARGGLIDTE 268 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDV------FRRLSACHNVLFTGH 295 A I+AL++ I MDVYE+E LFF D++ I+D + F RL+ N + + H Sbjct: 269 ALIDALESGVISGCAMDVYEHESGLFFTDRAVLPIEDRMKFWDKKFARLANLPNAIVSPH 328 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AFLT EAL +I+ TT++NL++ KGE N +V Sbjct: 329 VAFLTKEALKNIADTTIENLTSAFKGERNNNNMV 362 >UniRef50_B7S4E4 2-hydroxyacid dehydrogenase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7S4E4_PHATR Length = 313 Score = 275 bits (704), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 140/308 (45%), Positives = 197/308 (63%), Gaps = 5/308 (1%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 +EF L+E +A A G +A+C+FVND VL+ L GV+ IA+RCAGF+ VD A Sbjct: 1 MEFTTERLSESSATYAAGYDAICLFVNDTAGSEVLQTLSLMGVQMIAMRCAGFDRVDTKA 60 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE-GLTGFTMYGK 145 A+ G+ V RVPAY P AVAE AI ++MT+NR+I +A R + ANF+L+ GL G +YGK Sbjct: 61 ARAYGMTVARVPAYSPYAVAEMAIALLMTVNRKIAKASNRVKMANFTLDAGLMGMDIYGK 120 Query: 146 TAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHC 205 T GV+GTGKIG + RIL GFG +L+ +D Y S ELG YV +F++SD++ L Sbjct: 121 TVGVMGTGKIGQILCRILNGFGAKLICYDVYESDEVKELGGTYVSKEDIFAQSDILFLMM 180 Query: 206 PLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERD 265 PL +H +NE+ ++K GV+++NTSRG LID+ A ++ L++ I +GMDVYENE+D Sbjct: 181 PLLSATHHTINESVLPKLKKGVLLINTSRGGLIDTAALLKGLRSGIIRGVGMDVYENEQD 240 Query: 266 LFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLE----KG 321 FF+D S I+D L +NV+ T HQAF T EA+ I TT+ N+ + G Sbjct: 241 YFFQDWSARHIEDPDLVALLGNNNVVLTAHQAFFTQEAVDKIVSTTIDNIRDFHLKRLTG 300 Query: 322 ETCPNELV 329 ++ PN + Sbjct: 301 QSHPNNCI 308 >UniRef50_C5P2R3 D-lactate dehydrogenase, putative n=5 Tax=cellular organisms RepID=C5P2R3_COCP7 Length = 335 Score = 268 bits (684), Expect = 3e-70, Method: Compositional matrix adjust. Identities = 133/322 (41%), Positives = 192/322 (59%), Gaps = 1/322 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A +S ++K L+ N+ + EL FF L+E A G A+ FVND + Sbjct: 1 MRIAFFSILPHEKDALEAFNKEYHHELVFFKDSLSEANVALAAGFPAISAFVNDQLDSTI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + L + G +ALRC+G++ VD+ AA G+ V RVPAY PEA+ E+ +GM++ L+RR Sbjct: 61 MRALAESGTMLVALRCSGYDRVDIKAATANGITVTRVPAYSPEAIVEYTVGMLIALDRRT 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 A+QR R NF L G G ++GKT G++GTG+IG + R+ K GF +LA D YP+A Sbjct: 121 PHAWQRVRAGNFDLTGFVGHGIHGKTVGIVGTGRIGAGVARVFKNGFHCEVLANDLYPNA 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + GV YV+ L SD++ LHCPLT H++ MK ++VNTSRGAL++ Sbjct: 181 TLEQDGVRYVEFKELLKSSDIVCLHCPLTTATRHIIKAETLAIMKQNAILVNTSRGALVN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S + AL+ +I +DV E E FF+ + DDV RRL + NV+ TGHQAFL Sbjct: 241 SSDLLHALEKGRIRGCALDVVEGEEKYFFQSSNQAKHIDDVLRRLISLPNVMITGHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKG 321 T A+ SI++TTL+++ N E G Sbjct: 301 TRGAVDSIAKTTLKSIRNFESG 322 >UniRef50_D2QQC4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QQC4_9SPHI Length = 329 Score = 265 bits (678), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 131/323 (40%), Positives = 191/323 (59%), Gaps = 3/323 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M +A +ST +++ + Q + + +LT KTA A G AVC FVNDD SRPV Sbjct: 1 MNIAFFSTLSFEQAWFDQYRAHH--RITYIPEVLTTKTAHLAQGHNAVCTFVNDDLSRPV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L LK+ + + +RC G +NVDL A +LG+ ++ +Y P ++AEH + ++M + R + Sbjct: 59 LTLLKEMRIGVVGMRCMGTDNVDLQAITDLGMTLLHT-SYSPYSIAEHTVALLMGMVRHL 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A+ R + NF+++GLTG+ ++GKT G++GTG IG A +RI+ GFG ++LA+D P Sbjct: 118 PEAHNRVQARNFTIDGLTGYDLHGKTVGIVGTGHIGKAFIRIMLGFGCKVLAYDVCPDRR 177 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E+GV YV LP L +SDV+SLHCP T H++NE MK ++VNT RG L+D+ Sbjct: 178 LTEIGVTYVSLPELLRQSDVVSLHCPSTSITQHMINEQTLSLMKQSAILVNTGRGRLVDA 237 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + AL K+ DVYE ERD F D S + DD+ RL VL T HQ FLT Sbjct: 238 HAVLNALDAGKLAGYAADVYEGERDYFHYDYSGKSVPDDLLNRLRKHPGVLLTAHQGFLT 297 Query: 301 AEALTSISQTTLQNLSNLEKGET 323 +AL I+ + + S + +T Sbjct: 298 EDALRQIALSLINQFSFFDNKQT 320 >UniRef50_B5HCN2 D-lactate dehydrogenase n=6 Tax=Streptomyces RepID=B5HCN2_STRPR Length = 335 Score = 264 bits (675), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 142/329 (43%), Positives = 188/329 (57%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + +K +++ + D L TA A G E + VN V Sbjct: 1 MEILAFGVQADEKPLIEKAFADLPGGVRCLDVFLDADTAAIAAGHEVISTSVNAQLDAEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L G + IA R GFNN+DL+ A+ LGL V RV Y P +VAE A + M +NRR+ Sbjct: 61 LRTLAVGGTRMIAQRSTGFNNIDLEVAERLGLTVARVSYYSPYSVAEFAWTLTMAVNRRV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA RTRD +F L+GL G M G+TAGVIGTGKIG A RI GFGMRLL D P+ Sbjct: 121 VRAANRTRDFDFRLDGLMGRDMRGRTAGVIGTGKIGEAFTRIAHGFGMRLLGLDVAPNPV 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +ELG+EYVD L + +D++SLH PL P HL+ MK+ ++VN+SRG LIDS Sbjct: 181 CVELGMEYVDKDELLAAADLVSLHVPLMPATRHLIGARELRAMKDDAILVNSSRGGLIDS 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + L+ + +G+DVYE E LFF DKS + + DD RL NVL T HQA+ T Sbjct: 241 DALVGELRKGRFSGVGLDVYEAEAGLFFLDKSMEAVDDDTLARLMTFPNVLVTSHQAYYT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 A+A+T I TT +N+ +G N LV Sbjct: 301 ADAVTQIVDTTARNIKAHLEGRRGENVLV 329 >UniRef50_C9NGL5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=7 Tax=Streptomyces RepID=C9NGL5_9ACTO Length = 334 Score = 264 bits (675), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 143/320 (44%), Positives = 192/320 (60%) Query: 10 QYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGV 69 Q D+K L + + ++ D LTE TA A G E V VN D VL+ L G Sbjct: 9 QSDEKPLIEKAFAGLHDVRCLDVFLTEDTAPIAAGYEIVSTSVNADLGSRVLQTLAAGGT 68 Query: 70 KYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRD 129 + IA R GFNN+DLD A+ L L+V RV Y P +VAE A + M +NRRI RA RTRD Sbjct: 69 QMIAQRSTGFNNIDLDVAERLALRVARVSYYSPYSVAEFAWTLAMAVNRRIVRAVSRTRD 128 Query: 130 ANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYV 189 +F L+GL G M+G+TAGV+GTGKIG A RI GFGM LL +D + A LG+ YV Sbjct: 129 FDFRLDGLLGRDMHGRTAGVLGTGKIGEAFARIAHGFGMNLLGWDVAENPACTALGMTYV 188 Query: 190 DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKN 249 D L +E+D+ISLH PL P HL++E A MK+ ++VN+SRG L+D++A + L+ Sbjct: 189 DKEQLLAEADLISLHVPLLPATQHLIDERALSAMKDDAILVNSSRGGLVDTRALVGELRA 248 Query: 250 QKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQ 309 + +G+DVYE E LF+ DKS + I DD RL NV+ T HQA+ T +A+ I Sbjct: 249 GRFTGVGLDVYEAEAGLFYVDKSVEGIDDDTLARLVTFPNVIVTSHQAYYTRDAVGQIID 308 Query: 310 TTLQNLSNLEKGETCPNELV 329 T++N+++ G N LV Sbjct: 309 ATVRNVTDYLAGRRSDNVLV 328 >UniRef50_A4S3N1 Predicted protein n=2 Tax=Ostreococcus RepID=A4S3N1_OSTLU Length = 380 Score = 263 bits (671), Expect = 8e-69, Method: Compositional matrix adjust. Identities = 141/325 (43%), Positives = 203/325 (62%), Gaps = 14/325 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V+S +Y+ + L++ + + L+ TA A G +AVC+FV+DD V++ L Sbjct: 43 VFSAHRYEDETLRRALPNATYS----SARLSLDTASLAQGHDAVCVFVDDDARGEVVDAL 98 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + GVK I LRCAGF+NVD + A+E G+ V+RVPAYDP +++EHA+ MMM+LNR + + Sbjct: 99 AERGVKLILLRCAGFDNVDCERARERGISVLRVPAYDPLSISEHAVAMMMSLNRHLCASR 158 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAAALE 183 R R NF+L+GL G +M GKT GV+GTGKIG + ILK GF MR+L +D + + Sbjct: 159 DRLRMGNFTLDGLVGSSMRGKTVGVVGTGKIGRGVAEILKNGFQMRVLGYDKFEKD---D 215 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 +YV L L + SDV+SLH PLTPE ++ +MK G +++NTSRG L+D++AA Sbjct: 216 FCGDYVSLDELLARSDVVSLHLPLTPETRGMICVETIAKMKEGTILINTSRGLLVDARAA 275 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSN------DVIQDDVFRRLSACHNVLFTGHQA 297 I+ L + +I +LG+DVYENE LFF+D S+ ++ D+ L + VL T H A Sbjct: 276 IDGLYSGRIAALGLDVYENENRLFFKDFSSMNTNERMLVWDETMAILGSMPQVLVTPHTA 335 Query: 298 FLTAEALTSISQTTLQNLSNLEKGE 322 FLT EAL I++ T +N GE Sbjct: 336 FLTHEALDEIAKHTAENFRQFCAGE 360 >UniRef50_A7FYM9 D-lactate dehydrogenase n=10 Tax=Clostridium RepID=A7FYM9_CLOB1 Length = 336 Score = 254 bits (650), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 129/325 (39%), Positives = 197/325 (60%), Gaps = 2/325 (0%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK 65 Y + + ++ +E +G ++ A A G + + I ND +R LE++K Sbjct: 11 YCVRPDEVDSFKKFSEKYGHTVDLIPDSFGPNVAHLAKGYDGISILGNDTCNREALEKIK 70 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 G+KY+A R AG NN+D DAAKE G+ V VPAY P +V+E IG+ ++L R+I A + Sbjct: 71 DCGIKYLATRTAGVNNIDFDAAKEFGINVANVPAYSPNSVSEFTIGLALSLTRKIPFALK 130 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR-LLAFDPYPSAAALEL 184 R NF+L GL G + T GVIGTG+IG+ ++ GFGM+ ++ +D + + A + Sbjct: 131 RVELNNFALGGLIGVELRNLTLGVIGTGRIGLKVIEGFSGFGMKKMIGYDIFENEEAKKY 190 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 +EY L +F E+D+I+LH PLT +NYH++ + + +MK+GV I+N +RGALIDS+A I Sbjct: 191 -IEYKSLDEVFKEADIITLHAPLTDDNYHMIGKESIAKMKDGVFIINAARGALIDSEALI 249 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 E LK+ KI +D YE E+ +F +K N+++QDD RL + NV+ T H F T EA+ Sbjct: 250 EGLKSGKIAGAALDSYEYEQGVFHNNKMNEIMQDDTLERLKSFPNVVITPHLGFYTDEAV 309 Query: 305 TSISQTTLQNLSNLEKGETCPNELV 329 +++ + TL NL E TC N+ V Sbjct: 310 SNMVEITLMNLQEFELKGTCKNQRV 334 >UniRef50_C4K7N1 Fermentative D-lactate dehydrogenase, NAD-dependent n=1 Tax=Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) RepID=C4K7N1_HAMD5 Length = 260 Score = 246 bits (627), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 116/239 (48%), Positives = 162/239 (67%), Gaps = 5/239 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNE----SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 M + ++S + +D+++ ++N + GF L + LT+ + A G +A CIFVND Sbjct: 1 MWMIIFSAQNHDRQFFDKINRQQFTTQGFMLIYCKASLTKTSVNLAQGSDAACIFVNDQL 60 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +L++L + GV+ + LRCAGF+N+DL AAK+LGL V RVP Y P +VAEH I ++MTL Sbjct: 61 DGSILKQLSESGVRAVLLRCAGFDNIDLQAAKKLGLFVARVPEYSPGSVAEHTIALIMTL 120 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R IHR +R R+ NF+L+GL G T+ GKT G+IGTGKIG+ RILKGFG LL +DP Sbjct: 121 TRHIHRTDRRVREGNFALDGLLGKTVQGKTVGIIGTGKIGLMTARILKGFGCHLLGYDPA 180 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P++A E G YV+L TL S++D++SLHCPL +HL+NE MK G M++NTSRG Sbjct: 181 PTSAFRETG-HYVELDTLLSQADIVSLHCPLIKSTHHLINEKTLAHMKRGAMLLNTSRG 238 >UniRef50_C4XEL0 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XEL0_MYCFE Length = 350 Score = 235 bits (600), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 144/323 (44%), Positives = 188/323 (58%), Gaps = 11/323 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A + K+YDKKY VN E+++FD L T A G +A+C FVN G + + Sbjct: 6 MKIAFFDAKEYDKKYFDAVNNG-RHEIKYFDENLNINTVTKAKGFDAICAFVNTYGDKYI 64 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L K GVK R G+N +DL A ELG+ V RVP Y E+VAE A G ++ LNR I Sbjct: 65 LELLAKMGVKVWLQRSMGYNKIDLTKAAELGISVFRVPNYSAESVAEFAAGTLLALNRNI 124 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY---- 176 +A + NFSL GL G ++G T GVIG GKIG +RI+KG G R+L FD Y Sbjct: 125 VKAEKLVSKYNFSLNGLDGKAIHGSTVGVIGGGKIGQCFIRIMKGMGARILVFDAYNQKH 184 Query: 177 -PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P+ A ELG EY + ESD ISLH PL P HL+++ A + MK GV++VNT+RG Sbjct: 185 FPNLAT-ELGFEYASFTKVLKESDFISLHAPLLPSTTHLIDKDAVKIMKKGVILVNTARG 243 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQ----DDVFRRLSACHNVL 291 LID + LK I L DV E E F++D S++ + D + L + NV+ Sbjct: 244 ELIDIPGVLYGLKKGIIRGLASDVLEREEGRFYQDISSEANEYKKNDPEWEELISNENVI 303 Query: 292 FTGHQAFLTAEALTSISQTTLQN 314 T HQAFLT ALT I++ TL+N Sbjct: 304 ITSHQAFLTDVALTQIAKITLEN 326 >UniRef50_C4Z227 D-lactate dehydrogenase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z227_EUBE2 Length = 328 Score = 228 bits (581), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 124/333 (37%), Positives = 202/333 (60%), Gaps = 11/333 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG---- 56 MK+A +S +Q +K+Y + EL+ T ++ GCEA+ + DG Sbjct: 1 MKIAAFSVRQDEKQYFDTFANVYKVELQINRSGFTADDIESVKGCEAMSVC---DGMCDL 57 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 S PVLE+L GVKYI R G+N+VDL+AAK LG++V Y P +VA + + +M+ Sbjct: 58 SAPVLEKLAAEGVKYIGFRTIGYNSVDLEAAKRLGIRVAH-SGYSPYSVANYTVMLMLMC 116 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R+ R+ A++SL + G M T G+IGTG+IG A+++ L GFG +++A+DPY Sbjct: 117 IRKALYVMMRSHTADYSLGPICGREMQNMTVGIIGTGRIGKAVIKNLSGFGCKIIAYDPY 176 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 P A LE VEYV L L++ +D+ISLH L+ E YH++N+ + +MK+GV+++N +RGA Sbjct: 177 P-AKDLE-NVEYVTLDELYARADIISLHTFLSDETYHMINKDSIAKMKDGVILINAARGA 234 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFED-KSNDVIQDDVFRRLSACHNVLFTGH 295 L+D++ IEA+++ KIGS+G D E E + D K +D++ + + L + N + T H Sbjct: 235 LVDTKDLIEAVESGKIGSVGTDCCEGEDEFIRTDRKYDDLVVNHDYIILKSFQNTIVTPH 294 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 AF T +A++ + +++++++ GE P E+ Sbjct: 295 VAFFTDQAVSDMVESSVKSVVQFAAGEDTPLEV 327 >UniRef50_C3WFC0 D-lactate dehydrogenase n=2 Tax=Bacteria RepID=C3WFC0_FUSMR Length = 328 Score = 226 bits (575), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 125/330 (37%), Positives = 196/330 (59%), Gaps = 4/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL Y ++ +K + +++N+ FG++L + L+ ++ G +AV + N +R Sbjct: 1 MKLICYGVRKVEKPFFEKLNK-FGYDLTLVEELMNDENVNLIEGHQAVMLRANCPANRKN 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE++K GV+Y+ R G+N++DL+AA E+G K+ RVP Y P A+AE AI M L R+ Sbjct: 60 LEKMKNFGVEYLLTRTVGYNHIDLEAAYEMGFKMARVPRYSPNAIAELAITFAMNLVRKG 119 Query: 121 HRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 R+R+ NF + E + + T GVIGTGKIG ++ KG G R++A+D YPS Sbjct: 120 AYMVDRSRNKNFIVDEYMFSPEIRNLTVGVIGTGKIGFTAAKLFKGLGARVIAYDLYPSE 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCP-LTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA E+ VEYV + L +D+I+LHCP + EN +LL E +K+G +++NT+RG L Sbjct: 180 AAKEV-VEYVTMEELNKTADIITLHCPYIKGENDNLLGEEFISNLKDGAILINTARGELQ 238 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D +A I+ L++ KIG DV+ NE++ FF+D + I +V + +S VL T H Sbjct: 239 DVEAIIKGLESGKIGGFATDVFSNEKEFFFKDMAGKEIDKNVEKLISLYPRVLITPHIGS 298 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EALT++ + + +NL + C N+L Sbjct: 299 YTDEALTNMIEISYENLDEFLRTGDCQNKL 328 >UniRef50_D1PMF0 D-lactate dehydrogenase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PMF0_9FIRM Length = 328 Score = 222 bits (566), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 122/330 (36%), Positives = 196/330 (59%), Gaps = 6/330 (1%) Query: 1 MKLAVYSTKQYDK-KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ Y+ + +D+ +Y + E +G + ++ + + T + + A GC+AV N RP Sbjct: 1 MKILFYALRPFDELQYCEPNREKYGIDYKWTEEVPTPENLQLAEGCDAVS--TNPCEVRP 58 Query: 60 -VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 LE K GVKY+ R G++++ LDAAK LGL+V Y PE VA + I +M+ R Sbjct: 59 EYLEAFAKMGVKYLPCRSIGYDHIPLDAAKRLGLRVSHS-HYPPEGVANYTIMLMLMATR 117 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 ++++ R ++SL G G + T GVIGTGKIG ++R L GFG ++LA+D YPS Sbjct: 118 KMNQIMVRAAAQDYSLPGKMGHDLSSCTVGVIGTGKIGSTVIRHLSGFGCKILAYDLYPS 177 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A EYV L L++ SDVI+LH TPEN+HL+N A +MK+GV++VNT+RG LI Sbjct: 178 DAVRPYA-EYVSLNELYARSDVITLHLNATPENHHLINAEAITRMKDGVLLVNTARGTLI 236 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 DS++ ++ L++ KIG G+DV E+E + + ++ + + + L + NV+ + H AF Sbjct: 237 DSESLLQGLESGKIGGAGLDVVEDENGICYYNRCGEALPNRELNLLRSYPNVILSPHTAF 296 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T + S+ Q+ + +++ G + P E+ Sbjct: 297 YTDVNVASMVQSAFEAVADFAAGRSNPCEV 326 >UniRef50_Q0SVM3 D-lactate dehydrogenase n=31 Tax=Bacteria RepID=Q0SVM3_CLOPS Length = 332 Score = 214 bits (546), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 118/335 (35%), Positives = 192/335 (57%), Gaps = 12/335 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +KL Y ++ + Y ++NE FG++L + L + + A G EA+ + N R Sbjct: 2 IKLVCYGVRETEVPYFHKLNEEFGYDLTLVEKNLNHENVEEAIGAEAIMVRGNCMADRQN 61 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE LK G+KY+ R GF++VDL+AAK+LGL+V RVP Y P A+ E A+ + M L R Sbjct: 62 LELLKSKGLKYVLTRTVGFDHVDLEAAKDLGLQVARVPGYSPNAIGELAVSLAMMLLRHT 121 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGK-----TAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 RT + NF ++G M+ K T G++G G+IG+ ++ KG G +++A+D Sbjct: 122 AYTTHRTSNKNFVVDGF----MFSKEIRNCTVGILGAGRIGLTTAKLFKGLGAKVVAYDV 177 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCP-LTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + S AA E+ VE++ L + SDVIS+H P + +NYH++NE +MKN +I+NT+R Sbjct: 178 FQSDAAKEI-VEFMPLDEVLKVSDVISVHMPYIKGQNYHMINEEFISKMKNDAIIINTAR 236 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH-NVLFT 293 G L D +A ++AL+ ++G G DV E E +FF++ ++++ + +L + + L T Sbjct: 237 GELQDIEAIVKALEEGRLGGFGTDVLEGESAVFFKNLEGQKLENESYEKLISLYPRALVT 296 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T EAL ++ + +NL + TC N + Sbjct: 297 PHMGSYTDEALRNMIGISYENLKEYLEKNTCKNAI 331 >UniRef50_C8P1U4 D-lactate dehydrogenase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P1U4_ERYRH Length = 330 Score = 214 bits (545), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 118/318 (37%), Positives = 184/318 (57%), Gaps = 2/318 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL Y+ + +K+ ++ + +L+ + ++ ANG EAV N D SR V Sbjct: 4 MKLVAYAVRPDEKEAFERFTKEMNIDLKVVNAQMSIDNVNEANGYEAVAFLGNCDASREV 63 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L + G KYIA R AGFNNVD+DA ++LGLK Y P VA+ A+ +++ R + Sbjct: 64 LELLAQGGTKYIASRSAGFNNVDMDAVRDLGLKFSN-ATYSPNCVADFAVMLVLMSLRNM 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R ++SL G+ G M+ T GVIGTG+IG R L GFG R++ +D Y + + Sbjct: 123 KAIMKRAEVKDYSLPGIQGKEMHNMTFGVIGTGRIGCITARNLSGFGGRIIGYDLYENDS 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ++ + YVDL TL E+DVI+LH PL +H++N + K GV+IVN +RG LID+ Sbjct: 183 IKDV-LTYVDLETLLKEADVITLHAPLIESTHHIINAESLALTKPGVIIVNCARGELIDT 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I+ ++N IG++G+DV E E +F +D + + L + NV+ T H AF T Sbjct: 242 DALIKYVENGHIGAVGLDVLEGELGIFHKDHRLSTLSNHQLALLESHKNVIITPHCAFYT 301 Query: 301 AEALTSISQTTLQNLSNL 318 +A++ + + L++L++ Sbjct: 302 DQAVSDMVEVALRSLNSF 319 >UniRef50_B2UXX3 D-lactate dehydrogenase n=2 Tax=Clostridium RepID=B2UXX3_CLOBA Length = 328 Score = 214 bits (544), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 116/315 (36%), Positives = 193/315 (61%), Gaps = 2/315 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++T+ +K + ++ +++ + LT +T A G + V + N D + V Sbjct: 1 MEIIAFATRPDEKAGFDKFSKELNIKVKNINERLTLETVHEARGFKFVSVLGNCDVNSEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L + GV+YIA R AG+NN+D+ AKELG+ + Y P+ VA+ A+ +M+ R++ Sbjct: 61 LEKLNEFGVEYIASRSAGYNNIDIKKAKELGIGISN-ANYSPKCVADFAVMLMLMCIRKV 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R R ++S+ GL G M+ GVIGTGKIG A+++ L GFG ++LA+D Y + + Sbjct: 120 VWGLERARVNDYSVIGLQGKEMHNLVVGVIGTGKIGQAVIKNLSGFGCKILAYDIYENES 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ++ V+YVD+ TL+ E D+I++H PL NY+L+N+ + +MK+GV+I+NTSRG LI++ Sbjct: 180 -MKKYVQYVDMDTLYKECDIITIHSPLFDSNYNLINKESMRKMKDGVVIINTSRGELINT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + IEAL K+G++G+DV ENE +F D + + L NV+ T H AF T Sbjct: 239 RDLIEALDKGKVGAVGLDVLENEVGIFHSDCRFTGVNNKDIIMLKQMKNVILTHHFAFYT 298 Query: 301 AEALTSISQTTLQNL 315 +A+ + L++L Sbjct: 299 DQAVYDMVGCALKSL 313 >UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=A1W7V5_ACISJ Length = 337 Score = 214 bits (544), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 123/342 (35%), Positives = 193/342 (56%), Gaps = 22/342 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T++++ + Q++ G +L L N E + FV+ + V Sbjct: 1 MKILVVETEEWEHRACQRLLP--GHKLVCRSNALGPDEPTADNDAEVITPFVHSRLTAEV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L + + ++ IA R G++++DLD + G+ V VP Y VAEHA +++ ++R I Sbjct: 59 LAQFPR--LRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATVAEHAFALLLAVSRHI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +RTR +FS GL GF + GKT GV+GTG+IG ++ I KGFGM+++A+D +P AA Sbjct: 117 VTGAERTRRGDFSQHGLRGFELRGKTLGVLGTGRIGRRVIEIGKGFGMKIVAYDLFPDAA 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E LG EY+DL L S++DV++LH P TP+ +HLL + F MK G +++NT+RG ++D Sbjct: 177 VAEHLGYEYLDLHVLLSQADVVTLHVPATPQTHHLLGDPEFAAMKKGAVLINTARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDV------YENERDLFFEDKSND------VIQDDVFRRLSAC 287 + A + AL +K+ + G+DV E ++F D+ N ++ D V R S Sbjct: 237 TSALVRALSARKLRAAGLDVLPAEPLIREEAEIFRNDRRNSDTDLRALLADHVLLRFS-- 294 Query: 288 HNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 NV+ T H A+ T EAL I TT+ N+ +G+ P LV Sbjct: 295 -NVIVTPHVAYDTDEALRRILDTTIANIEAFARGQ--PRNLV 333 >UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1CAH7_SPHTD Length = 348 Score = 211 bits (538), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 118/298 (39%), Positives = 169/298 (56%), Gaps = 14/298 (4%) Query: 34 LTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLK 93 L E + A E V +F++ RP LE L + ++ IA R G++++DL A E G+ Sbjct: 41 LDEDSTHLAAEAEIVSVFIHSRLDRPTLERLPR--LRLIATRSTGYDHIDLAACAERGVV 98 Query: 94 VVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTG 153 V VP Y VAEH G+++ L+R IHRAY RT+ +FSL GL GF + GKT GVIGTG Sbjct: 99 VTNVPYYGENTVAEHTFGLILALSRNIHRAYVRTQRGDFSLAGLEGFDLKGKTLGVIGTG 158 Query: 154 KIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENY 212 IG+ ++RI KGFGM ++A D PS E LG YV L L SD+ SLH P P + Sbjct: 159 SIGLHVIRIAKGFGMEVVAHDLRPSRILPEVLGFRYVPLDELLQVSDIASLHVPYLPATH 218 Query: 213 HLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKS 272 HL+N F +MK G +++NT+RG L+D+++ + AL + G+DV E E +++S Sbjct: 219 HLMNRETFARMKRGSLLINTARGGLVDTESLMWALDEGILAGAGLDVLEGEE--LIQEES 276 Query: 273 NDVIQDDVFRRLSAC---------HNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 + Q V +L A NV+ T H AF + EA+ I T++N++ G Sbjct: 277 QLLTQPAVEDKLRAVLRQHLLARRENVVITPHIAFYSTEAVHRIMDVTIENINAFLDG 334 >UniRef50_C3RQ64 D-lactate dehydrogenase n=4 Tax=Bacteria RepID=C3RQ64_9MOLU Length = 330 Score = 205 bits (522), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 110/328 (33%), Positives = 185/328 (56%), Gaps = 2/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + + + +N S FE+ ++ L +K NG + + + + Sbjct: 1 MKIIAFEVRSDEMADFEIMNNSNNFEITYYKEYLCQKNLSLLNGYDGIAFLGESKINHEI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ + K G+ IA R G++++D++ AKELG+KV +Y PE VA+ + +M+ R Sbjct: 61 LDAIAKAGIGVIATRTIGYDHIDIEYAKELGIKVCN-SSYGPEGVADFTVMLMLLSLRHY 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + ++SL+GL G M T G++GTG+IG A+L+ L GFG RLLA+D + + Sbjct: 120 KKALWLGQVNDYSLQGLEGREMKDLTIGIMGTGRIGQAVLKNLSGFGARLLAYDIHQNET 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A ++ YVDL + E D+ISLH P +HL+N+ +MK+G++I+N +RG L ++ Sbjct: 180 A-KIYATYVDLEQFYQECDIISLHMPYLKSTHHLINDQTISKMKDGIIIINCARGQLCNT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 ++ I ++N+KIG+LG+DV E E ++ +D D+I++ L NV+ T H AF T Sbjct: 239 ESLIRGIENKKIGALGLDVVEGEEGIYHQDMRTDIIKNKNMAYLRQFPNVVMTQHLAFYT 298 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A++S+ Q +L L NEL Sbjct: 299 DAAVSSMVQLSLNGLWACYNDLDWDNEL 326 >UniRef50_C1BVE3 D-lactate dehydrogenase n=1 Tax=Lepeophtheirus salmonis RepID=C1BVE3_9MAXI Length = 339 Score = 201 bits (512), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 113/317 (35%), Positives = 182/317 (57%), Gaps = 6/317 (1%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFL--LTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + T+ + K ++++ E GFE E + + E + A G +A+ IFVN +E Sbjct: 7 IIDTRCHLNKSMKKIFEKNGFECEVAEGFSGVPEDVLRKAKGFQAIVIFVNKKLQDSDVE 66 Query: 63 ELKKHGVKYIALRCAGFNNV-DLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 LK +G K I AGF+N+ D KE G++V RVP+Y P ++AE+AI M L + I Sbjct: 67 ILKDNGNKMILCCSAGFDNIPKHDLLKEAGIRVARVPSYSPSSIAEYAISSMFALAKNIQ 126 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 R+Y+ T+ A+F + GL + KT G+IGTG IG ++ + G ++L +D YP+ Sbjct: 127 RSYEMTKLADFRIGGLHCILLEDKTVGIIGTGLIGKKTVQKVAGMVDKVLCYDAYPANDW 186 Query: 182 LEL--GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++ EYVD+ TLF+ S++IS+H PL E HL+N+ E+MK V+I+NTSRG +I+ Sbjct: 187 IKTVPNAEYVDMDTLFANSNIISIHVPLLKETQHLINKDTIEKMKKDVIIINTSRGEIIN 246 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQD-DVFRRLSACHNVLFTGHQAF 298 + ++ LK++KI + +DV+E E+ F+D S ++ L + NV+ + H AF Sbjct: 247 TPDLVDGLKSKKIMGVALDVFEGEKAFMFKDMSKVGFENYPELEDLVSMDNVIISSHVAF 306 Query: 299 LTAEALTSISQTTLQNL 315 T E++ I+ T N Sbjct: 307 YTDESIRQITDKTYNNF 323 >UniRef50_C4F960 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F960_9ACTN Length = 382 Score = 201 bits (511), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 117/331 (35%), Positives = 188/331 (56%), Gaps = 5/331 (1%) Query: 1 MKLAVYSTKQYDKK-YLQQVNE-SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK+ V+ + ++ Y + V E G E+ + LT T +G E V I Sbjct: 54 MKIKVFELRDDERAAYDRVVGELPAGCEVAWSADTLTSATLDMLDGAEGVVIVNKSPLDA 113 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +L EL GV+Y+A R GFN++D+DAAKELG+ V Y P VAE A+ +M+ R Sbjct: 114 DMLRELHDRGVRYVATRSIGFNHIDIDAAKELGIHVCNT-TYPPYGVAEFAVMLMLMALR 172 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 A R + ++SL GL G + T GV+GTG+IG A++ L+GFG ++LA+DP+PS Sbjct: 173 NYKPAMWRQQVNDYSLAGLRGRELRTLTVGVMGTGRIGRAVIDYLRGFGCKILAYDPFPS 232 Query: 179 AAALELG-VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 G V YV L L+++SD++++H PL +++ A +M++GV++VN SRG L Sbjct: 233 EELAARGDVTYVGLDELYAQSDLVTVHIPLMESTRGIIDCEAIAKMRDGVVLVNVSRGEL 292 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D A +E ++++KIG+L MDV+ E ++ +++D++ + L NV+ T H A Sbjct: 293 MDVDALVEGIESEKIGALAMDVFPEEDGIYHVSRTHDILANRNMAYLRQFPNVILTQHIA 352 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T + S+ + ++ + + GE CP EL Sbjct: 353 FYTDIDVDSMVEQGIRGILAMATGE-CPTEL 382 >UniRef50_A6LTK2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=15 Tax=Bacteria RepID=A6LTK2_CLOB8 Length = 327 Score = 199 bits (505), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 104/328 (31%), Positives = 197/328 (60%), Gaps = 3/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ YS ++ + +Y ++ ++ + E+ + + +TA A G + + I + S + Sbjct: 1 MRILAYSHRRDETQYFEEFSKKYNVEVVLCNEEPSLETAPLAKGFDCISIITTNINSE-L 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + + + GVK+I+ R G++++DL AKELG++V V Y P +VA++ I +++ R++ Sbjct: 60 VGKFHELGVKFISTRTIGYDHIDLKKAKELGVRVGNV-TYSPNSVADYTIMLILMAVRKV 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R+ +FSL G+ G + T GV+GTGKIG +++ L GFG ++LA D Y + Sbjct: 119 KLIMERSNVQDFSLRGIQGKELPNLTIGVVGTGKIGRTVIKHLSGFGCKILAHDIYENDE 178 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ++ +YVDL LF SD+I+LH P T +NYH++N+ A + MK+GV I+NT+RG+LI++ Sbjct: 179 -VKSNAKYVDLENLFKYSDIITLHMPATDDNYHIINKKAIKLMKDGVFIINTARGSLINT 237 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 I ++++KIG +DV E E ++++ D + +++ L + NV+ T H AF T Sbjct: 238 NDLIHGIESKKIGGAALDVIEQESNIYYSDLKGEALKNRNLAILKSFPNVIITPHAAFYT 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +A++ + + ++++ + + P E+ Sbjct: 298 DQAVSDMIENSIKSCILFSENKENPWEI 325 >UniRef50_P17584 D-2-hydroxyisocaproate dehydrogenase n=9 Tax=Lactobacillus RepID=DHD2_LACPA Length = 333 Score = 197 bits (500), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 108/326 (33%), Positives = 181/326 (55%), Gaps = 3/326 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ Y + + +Y +Q + G LE+ L E T + A G + + + V Sbjct: 1 MKIIAYGARVDEIQYFKQWAKDTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E++ +G+K++ +R G +N+D+ A K+ G+++ VPAY P A+AE A+ + L R + Sbjct: 61 FEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNM 120 Query: 121 HRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + + + ++ G G + +T GV+GTG IG +++ KGFG +++A+DPYP Sbjct: 121 GKVQAQLQAGDYEKAGTFIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +YV L LF +SDVI LH P +N H++NEAAF MK G +++NT+R LID Sbjct: 181 GD-HPDFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLID 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +QA + LK+ K+ +G+D YE E + + +D ++ L NV+ + H A+ Sbjct: 240 TQAMLSNLKSGKLAGVGIDTYEYETEDLLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYY 299 Query: 300 TAEALTSISQTTLQNLSN-LEKGETC 324 T A+ ++ +LQ+L + L KGET Sbjct: 300 TETAVHNMVYFSLQHLVDFLTKGETS 325 >UniRef50_P26297 D-lactate dehydrogenase n=73 Tax=Lactobacillales RepID=LDHD_LACDA Length = 333 Score = 191 bits (484), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 112/320 (35%), Positives = 173/320 (54%), Gaps = 5/320 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K+ Y+ ++ +K +L++ ++ E+E+ D LLT +T A G + V ++ D + Sbjct: 3 KIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGVVVYQQLDYTAET 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L +G+ ++LR G +N+D+ AKELG ++ VP Y P A+AEHA + R+ Sbjct: 63 LQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILRQD 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 ++ + G + + GVIGTG IG ++I++GFG +++A+D + + Sbjct: 123 KAMDEKVARHDLRWAPTIGREVRDQVVGVIGTGHIGQVFMQIMEGFGAKVIAYDIFRNPE 182 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LE YVD L L+ ++DVISLH P P N H++N+ + +MK V+IVN SRG L+D Sbjct: 183 -LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVD 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A I L + KI MDVYE E +F ED D L A NVL T H AF Sbjct: 242 TDAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAFY 301 Query: 300 TAEALTSISQTTLQNLSNLE 319 T A+ ++ N NLE Sbjct: 302 TTHAVRNMVVKAFDN--NLE 319 >UniRef50_Q59642 D-lactate dehydrogenase n=5 Tax=Lactobacillaceae RepID=LDHD_PEDAC Length = 331 Score = 190 bits (483), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 108/329 (32%), Positives = 178/329 (54%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ Y + +K YL + E++ LL A + V + + + Sbjct: 1 MKIIAYGIRDDEKPYLDEWVTKNHIEVKAVPDLLDSSNIDLAKDYDGVVAYQQKPYTADL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +++ + G+ +LR G +NV DA K+ +K+ VPAY P A+AE ++ ++ L R+I Sbjct: 61 FDKMHEFGIHAFSLRNVGLDNVPADALKKNDIKISNVPAYSPRAIAELSVTQLLALLRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + ++ E G + T GVIGTG+IG A + I K FG +++A+D + + A Sbjct: 121 PEFEYKMAHGDYRWEPDIGLELNQMTVGVIGTGRIGRAAIDIFKPFGAKVIAYDVFRNPA 180 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + G+ YVD L L+ +++VI+LH P +NYH+L+E AF QM++G I+N +RG L+D Sbjct: 181 LEKEGM-YVDTLEELYQQANVITLHVPALKDNYHMLDEKAFGQMQDGTFILNFARGTLVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A ++AL + K+ +D YENE +F D + I D VF L + NV+ T H AF Sbjct: 240 TPALLKALDSGKVAGAALDTYENEVGIFDVDHGDQPIDDPVFNDLMSRRNVMITPHAAFY 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ ++ Q L N +L + + NE+ Sbjct: 300 TRPAVKNMVQIALDNNRDLIEKNSSKNEV 328 >UniRef50_C0GGJ9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGJ9_9FIRM Length = 335 Score = 190 bits (482), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 107/307 (34%), Positives = 174/307 (56%), Gaps = 18/307 (5%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 L F + L++K + E + +F+ + +L +L +K I R +GFN++DL A Sbjct: 26 LSFTEEPLSDKNIADFSDSEIISVFIYSHATAELLSQLP--NLKLILTRSSGFNHIDLKA 83 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKT 146 A E + V VP Y VAEHA +++TL+R I++AY RT+ +FSL+GL GF + KT Sbjct: 84 ATERNIPVCNVPVYGENTVAEHAFALILTLSRNIYKAYLRTQREDFSLKGLQGFDLKDKT 143 Query: 147 AGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHC 205 V+G G+IG+ +++I + F M++LA DP P E L Y L + + +D+ISLH Sbjct: 144 LAVVGAGRIGLHVIKIARSFNMKVLAVDPTPDPFLAEVLQFSYAPLEEVLTRADIISLHA 203 Query: 206 PLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERD 265 PL + +HLLN+ +K G +++NT+RG L+++ A + AL + I G+DV E+E + Sbjct: 204 PLNEKTHHLLNKENISTIKKGALLINTARGELVETDALLAALNDGTIAGAGLDVLESE-E 262 Query: 266 LFFEDKS-----------NDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 LF ED+ V+++ + L +V+ T H F + EA+ I +TT+QN Sbjct: 263 LFVEDEKLFSPHTPPETLTTVLKNHI---LLNREDVVITPHIGFNSKEAVHRIRETTVQN 319 Query: 315 LSNLEKG 321 ++ G Sbjct: 320 ITAFLAG 326 >UniRef50_B1C8M4 Putative uncharacterized protein n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1C8M4_9FIRM Length = 225 Score = 189 bits (480), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 102/223 (45%), Positives = 157/223 (70%), Gaps = 6/223 (2%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ ++TK YD K+ N++ +E++F++ L + +A A+G + FVND+ + + Sbjct: 3 KICFFNTKSYDIKWFDHYNKN--YEIKFYESRLNKNSAILASGSGGIISFVNDNLDKDTI 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + L + GVK IALRCAG+N+VDL+AAK+ +K++ VP+Y P +VAE+AIGM +TLNR+IH Sbjct: 61 DILYELGVKVIALRCAGYNHVDLNAAKD-KIKILNVPSYSPSSVAEYAIGMFLTLNRKIH 119 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 +AY +TRD NFSL G+ GF + GKT G+IGTGKIG ++ I KGF M ++A+D +P Sbjct: 120 KAYTKTRDYNFSLNGMVGFDLKGKTIGIIGTGKIGEELIEICKGFKMNVIAYDLFPKKDG 179 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMK 224 ++YVDL TL + SD+ISLHCPLT + +L+N+ ++++ Sbjct: 180 ---DIQYVDLNTLLNNSDIISLHCPLTKDTKYLINKKTLQKIE 219 >UniRef50_O83080 D-lactate dehydrogenase n=2 Tax=Treponema pallidum RepID=LDHD_TREPA Length = 331 Score = 188 bits (478), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 109/331 (32%), Positives = 182/331 (54%), Gaps = 5/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M+ V++ ++ + Y+++ +S G ++ ++ LT K + G E + + Sbjct: 1 MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR- 118 V + + +K ++ R AGF+ + K+ G+++ VP+Y P A+ E+A+ + L R Sbjct: 61 VYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRH 120 Query: 119 -RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R + R RD + L+ + G++GTG+IG A R+ KG G +++ FDPYP Sbjct: 121 AREIETFVRKRDFRWQKPILSK-ELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYP 179 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + AA E + YV + L S SDVISLH P T +++HL+N QMK+GV +VNT+RGA+ Sbjct: 180 NDAAKEW-LTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAV 238 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 IDSQA +++L KI +D YE E +D N+ I D V+ RL A +++T H A Sbjct: 239 IDSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIA 298 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T A+ ++ +L + + +GE C E+ Sbjct: 299 FYTETAIENMVFNSLDACTTVLRGEPCAAEI 329 >UniRef50_Q6RK69 D-lactate dehydrogenase n=4 Tax=Lactobacillus RepID=Q6RK69_9LACO Length = 331 Score = 186 bits (472), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 110/333 (33%), Positives = 183/333 (54%), Gaps = 7/333 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL VY+ + + ++++ E+ L +TA A G + V S+ + Sbjct: 1 MKLIVYNVRDDEIPFVEKWGRDHQIEVTTTTTTLNTETAAEAAGFDGVSCLQTIPYSKEL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++ G+ Y+ALR G +N+D+ AAK +K+ VPAY PE++AE A+ M + L+R++ Sbjct: 61 FAALQRLGIHYLALRNVGTDNIDIQAAKANNVKITNVPAYSPESIAEFAVMMALYLSRKV 120 Query: 121 ---HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + Q + +FS G + +T GVIGTG+IG +++ +G G ++A+D YP Sbjct: 121 GYMQQQLQEQHEFHFS-PAFMGRLISEQTVGVIGTGRIGRHAIQLFRGLGANVIAYDKYP 179 Query: 178 SAAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 +YVD L + +SD+ISLH P T +N+HL N FE+MK +++NT+RG Sbjct: 180 QKITGG-AFKYVDHLEDIIKQSDIISLHMPATADNFHLFNHEVFEEMKPNAILINTARGT 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D+ I AL++ +I + G+D E+E + +S I D +LS NV+ T H Sbjct: 239 IVDTNDLIFALESGEIAAAGIDTLEDESIDLQDSRSTKKITDADLIKLSMMPNVILTPHS 298 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AF T E++ ++ +L NL + +G P +LV Sbjct: 299 AFHTTESVKNMVNISLNNLKTMAEGGK-PADLV 330 >UniRef50_A5VLZ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=19 Tax=Lactobacillus RepID=A5VLZ7_LACRD Length = 330 Score = 183 bits (465), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 107/330 (32%), Positives = 175/330 (53%), Gaps = 4/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDD-GSRP 59 MKL +YS + +K Y++ + G +++ L T K A G + + + G Sbjct: 1 MKLIMYSVRDAEKPYIEAWEKKTGNDVKMVTEPLNADTVKLAEGYDGISLQQTTKLGDEQ 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + E+L G+K +A R G + DLDA K G+ V VP Y P A+AE + M L RR Sbjct: 61 LYEQLAAMGIKQLAARMVGVDIFDLDACKANGIIVTNVPIYSPRAIAEMGVTQAMYLLRR 120 Query: 120 IHRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 I QR +F + L +Y T G++G G IG A +I K G ++LA+DP + Sbjct: 121 IGEFEQRMSHGDFRWSDDLISNEIYNLTVGIVGLGNIGGATAQIYKALGAKVLAYDPSYN 180 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 E VEY D T+ +D++SLH PL P +++ F+ MK+ ++N +RG L+ Sbjct: 181 VE-YEPYVEYTDFDTVIKNADILSLHTPLLPSTENMIAAPQFKMMKDNAYLINMARGKLV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ I AL+N++I G+D +E F + ++D I DD +++L+A NVL T H AF Sbjct: 240 NTADLISALENKEIAGAGLDTLADETSFFGKQVTSDQIPDD-YKKLAAMPNVLVTPHVAF 298 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 LT ++ ++ + +L + + +G+ NE+ Sbjct: 299 LTETSIRNMVEISLNDAVTILEGKHSRNEI 328 >UniRef50_C1P7N1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Bacillus coagulans 36D1 RepID=C1P7N1_BACCO Length = 329 Score = 183 bits (464), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 114/323 (35%), Positives = 181/323 (56%), Gaps = 3/323 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ Y T+ + Q+ F ++++ D +LT +TA A G EAV I N Sbjct: 3 KVVAYETRADEFPLFQKFARKFDLDIKYVDDVLTPETAMKAMGAEAVTILGNYPVGAETF 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 L+ GVKYI LR AG+N++D +AAK G++ V AY P VA+ A +++ R+ Sbjct: 63 MALRDAGVKYIGLRTAGYNHIDQEAAKAYGIRFSNV-AYSPYCVADFATMLILMCVRKAK 121 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 + R +FS+EG+ G M+ T G+IG G+IG + + L GFG ++A D Sbjct: 122 QILSRVETQDFSVEGIQGREMHNLTIGIIGAGRIGSIVAKNLSGFGCNIIAHDTVERDE- 180 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 L ++YV L L ESDVI++H PL YH++N+ +MK+GV I+N SRGA++D+ Sbjct: 181 LRGILKYVSLDELLKESDVITIHTPLFDRTYHMINQDRIAKMKDGVCIINCSRGAVVDTD 240 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A I ++ K+G+ G+DV E+E +F D+ D++ L + NV+ T H AF T Sbjct: 241 ALIAGIEAGKVGAAGIDVLEDEEGIFHYDRRTDILAHHQLAILRSFPNVIVTPHTAFYTD 300 Query: 302 EALTSISQTTLQNL-SNLEKGET 323 +A++ + + L +L S +E G++ Sbjct: 301 QAVSDMVEMALTSLVSFMETGKS 323 >UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Acidovorax RepID=A1W9A3_ACISJ Length = 339 Score = 181 bits (458), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 105/283 (37%), Positives = 162/283 (57%), Gaps = 8/283 (2%) Query: 46 EAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAV 105 E +C+FV VL L + ++ +A R AGF+++DL+A ++ G+ V VP Y +V Sbjct: 51 EVLCVFVRTRVDESVLRMLPR--LRLVATRSAGFDHIDLEACRKRGIAVCHVPDYGSASV 108 Query: 106 AEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKG 165 AEHA +++ + R + +A++R R +F+ GLTGF + G+T G++G G+IG + RI G Sbjct: 109 AEHAFALLLGVTRHLTQAHERARQGSFAYRGLTGFELEGRTLGIVGLGRIGRHVARIAVG 168 Query: 166 FGMRLLAFDP-YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMK 224 FGM +LA+DP + ++AA GV V + SD++SLH P T HL++ AF +MK Sbjct: 169 FGMDVLAYDPAFAASAARPAGVSLVTWEQVLQGSDILSLHVPATEATRHLIDARAFARMK 228 Query: 225 NGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSN-DVIQDDVFRR 283 GV+++NT+RGALID A + AL + + + G+DV E E L E + + D Sbjct: 229 PGVVVINTARGALIDEAALLRALDDGSVAAAGLDVLEQEGALSPEVPTGCGGLGCDTGWM 288 Query: 284 LSA---CH-NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 S+ H VL T H F T EA+ I T+ N++ G Sbjct: 289 ASSPLLTHPRVLVTPHVGFNTTEAIARIFDETISNIAAWHAGR 331 >UniRef50_O66939 D-lactate dehydrogenase n=1 Tax=Aquifex aeolicus RepID=O66939_AQUAE Length = 334 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 104/283 (36%), Positives = 158/283 (55%), Gaps = 9/283 (3%) Query: 45 CEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEA 104 E + +FV D + +L ++ + +K I R GF+++DLD K+ G+ V +PAY PE+ Sbjct: 43 AELISVFVYDKLTEELLSKMPR--LKLIHTRSVGFDHIDLDYCKKKGILVTHIPAYSPES 100 Query: 105 VAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIG--VAMLR 161 VAEH M++TL +R+ R R + NFS + + + T GVIGTG+IG VAM Sbjct: 101 VAEHTFAMILTLVKRLKRIEDRVKKLNFSQDSEILARELNRLTLGVIGTGRIGSRVAMYG 160 Query: 162 ILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFE 221 + FGM++L +D E G Y L L ESDVISLH P T E +H++NE Sbjct: 161 L--AFGMKVLCYDVVKREDLKEKGCVYTSLDELLKESDVISLHVPYTKETHHMINEERIS 218 Query: 222 QMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVF 281 MK+GV ++NT+RG ++D+ A A + K LG+DV+E+E L + + D Sbjct: 219 LMKDGVYLINTARGKVVDTDALYRAYQRGKFSGLGLDVFEDEEILILKKYTEGKATDKNL 278 Query: 282 RRLS-ACH-NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 + L AC NV+ T H A+ T ++L I + T++ + KG+ Sbjct: 279 KILELACKDNVIITPHIAYYTDKSLERIREETVKVVKAFVKGD 321 >UniRef50_Q47748 D-specific alpha-keto acid dehydrogenase n=50 Tax=Bacteria RepID=VANH_ENTFA Length = 323 Score = 178 bits (452), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 101/320 (31%), Positives = 168/320 (52%), Gaps = 6/320 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V+ +Q + + ++ F ++ AK A G + + + + S Sbjct: 5 MGITVFGCEQDEANAFRTLSPDFHIIPTLISDAISADNAKLAAGNQCISVGHKSEVSEAT 64 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + L+K GVKYI+ R G N++D AA+ +G+ V V AY P++VA++A+ +M+ R Sbjct: 65 ILALRKVGVKYISTRSIGCNHIDTTAAERMGISVGTV-AYSPDSVADYALMLMLMAIRGA 123 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 NF L+ + G + T GVIGTG IG A+++ L+GFG R+LA+D Sbjct: 124 KSTIHAVAQQNFRLDCVRGKELRDMTVGVIGTGHIGQAVVKRLRGFGCRVLAYDN----- 178 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + ++ +YV L L SD+++LH PL + HL+ + +MK G ++NT RGAL+D+ Sbjct: 179 SRKIEADYVQLDELLKNSDIVTLHVPLCADTRHLIGQRQIGEMKQGAFLINTGRGALVDT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + +EAL + K+G +DV E E + D S V+ +L NV+ T H A+ T Sbjct: 239 GSLVEALGSGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMPNVIITPHTAYYT 298 Query: 301 AEALTSISQTTLQNLSNLEK 320 L ++ T++N N E+ Sbjct: 299 ERVLRDTTEKTIRNCLNFER 318 >UniRef50_B2GCQ6 D-2-hydroxyisocaproate dehydrogenase n=3 Tax=Lactobacillus fermentum RepID=B2GCQ6_LACF3 Length = 327 Score = 178 bits (451), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 105/322 (32%), Positives = 168/322 (52%), Gaps = 2/322 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ +YS ++ Y++ G +++ + L ++TAK A G + + +D V Sbjct: 1 MKILMYSILDTERPYVEAWVNKTGHQVKMVEEGLNKETAKWAAGFDGIDFQQTNDLDPEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ G+K + R GF+ +DL A + L V VPAY P A+AE + + L R++ Sbjct: 61 YATLEGLGIKQLTARMVGFDMIDLKQAADHHLLVTNVPAYSPRAIAEMGLTQALRLVRKL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 QR + +F GL +Y T GVIG G IG A R+ G +LA DP A Sbjct: 121 GYYDQRMDNYDFRWVGLESTEIYNLTVGVIGAGHIGGATARLYSALGANVLATDPV-HHA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LE + YVDL TL E+D++++H PL E +LL+ AF +MK+ ++N +RG L+D+ Sbjct: 180 ELEADLTYVDLETLLREADIVTIHTPLNEETANLLDRTAFAKMKDSAYLINMARGGLVDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEAL+N ++ +D +E F S + + + + L A NVL + H AF T Sbjct: 240 AALIEALQNHQLAGAALDTLADETGYFERQASREEVSES-YLTLRAMPNVLISPHSAFFT 298 Query: 301 AEALTSISQTTLQNLSNLEKGE 322 A+ +I + L ++ + G+ Sbjct: 299 DTAIKNIVEMGLDDVVRIVNGK 320 >UniRef50_B9DL13 D-specific D-2-hydroxyacid dehydrogenase n=4 Tax=Staphylococcus RepID=B9DL13_STACT Length = 331 Score = 175 bits (444), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 103/330 (31%), Positives = 175/330 (53%), Gaps = 5/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +K+ ++ + Y+++Y++ + E++F LT++ A + V + N + Sbjct: 2 VKIKMFDVENYEEQYIKDWVKEHQIEVDFEHGPLTKEKATQLKDYDGVSLSHNGPFDSDL 61 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E L HG+K IA R AGF+ DL+ A+E G+ + VP+Y P ++AE+A+ + R++ Sbjct: 62 YEVLASHGIKQIAQRSAGFDMYDLEKAREWGITITTVPSYSPSSIAEYAVMGTLYFARQV 121 Query: 121 HRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 QR +F +G + T+ T VIG G+IG R+ FG +++ +DP Sbjct: 122 PLIRQRVHQHDFRWKGDIMSRTVKDLTVAVIGIGRIGSISARLFHSFGCKVVGYDPI-RR 180 Query: 180 AALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 +E VEY + L +E+D+++LH P E YHL +E F K + VN +RG ++ Sbjct: 181 PEMEDIVEYKESLLEAITEADIVALHIPGNKETYHLFDEEVFRHFKTETIFVNAARGMVV 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D++A ++AL + KI +D YENE + + D S I+DD+ L +VL + H AF Sbjct: 241 DTKAFLKALNSDKIIGAVIDTYENEAEYYRRDHSGKEIKDDILLHLIERDDVLVSPHIAF 300 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+ ++++ L S LE T +E Sbjct: 301 FTGEAVKNLTEGGLN--STLEVLTTGDSEF 328 >UniRef50_C0QZF2 Lactate dehydrogenase-like dehydrogenase n=2 Tax=Brachyspira RepID=C0QZF2_BRAHW Length = 331 Score = 172 bits (437), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 92/328 (28%), Positives = 173/328 (52%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + VYS + ++ + + + + + L K A G ++V D + V Sbjct: 1 MSIVVYSFLDDESEFFKLMEKKYNTKFTLHKHHLNIDNVKDAEGFDSVVFNARDAITSEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++LK++GVKY++ R G++N+D+D A ++G+K+ VP+Y P +V+E I ++++ + Sbjct: 61 LDKLKEYGVKYMSTRSVGYDNIDIDYANKIGIKIANVPSYSPNSVSEFTILSLLSIVKNY 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + + N++ GL + GVIGTG+IG ++ LKGF + + Sbjct: 121 NNLLINGYNRNYTRTGLVAKEIRNLNIGVIGTGRIGSLTVKHLKGFSPKNIFVYSRTEKE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ++ +YV L L+ SD I H P E +++ + + +MK GV I+N SRG ++++ Sbjct: 181 EIKQYAKYVSLDELYKNSDAIIYHIPYNKETENMICKDSINKMKKGVYIINVSRGGIVNN 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + ++ LK+ IG +DVY NE + ++ + V++D++ L NV+ T H AF T Sbjct: 241 KDLLDGLKSGHIGGAALDVYTNEIEYVNKNIKDIVLKDEIIEELFKMDNVIITPHFAFYT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL ++ ++ N+ + C N++ Sbjct: 301 DEALLNMVSISIDNIFEFKNTGKCVNQI 328 >UniRef50_A5IXT8 D lactate dehydrogenase n=4 Tax=Mycoplasma RepID=A5IXT8_MYCAP Length = 329 Score = 171 bits (434), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 105/334 (31%), Positives = 185/334 (55%), Gaps = 11/334 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M + + K+ + ++V E + +L +++++ +G + V + ND +R Sbjct: 1 MNVIFFGIKEVEFPIFEKVKEKYKDLKLTAVTEVISKERIHLVDGMDCVVVRENDVVNRE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE LK G+ Y+ R AGF+++DL A ELG+K+ RVP+Y P A+AE A L+RR Sbjct: 61 ILELLKAKGINYVFTRTAGFDHMDLAAGHELGIKMARVPSYSPTAIAELAFSYAHQLSRR 120 Query: 120 -IHRAYQRTRDANFSLEGLTGFT--MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 +H Y + +F+++ GF + T ++GTGKIG ++ K FG ++L +D Sbjct: 121 SLHFGY-KAHKKDFTVDDF-GFAKELRSSTVLIMGTGKIGYESAKMFKSFGAKVLGYDLM 178 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCP-LTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P+ A ++ +EYV L ++D+++LH P + +N L++ +MK+G ++VNTSRG Sbjct: 179 PNKALTDV-IEYVSLDEGLKQADIVTLHMPYIKGQNDKLVSAELLSKMKDGAILVNTSRG 237 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRR-LSACHNVLFTG 294 + D +A ++A+K+ K+ +DV+ NE+ F K+ D I+D V L V+ + Sbjct: 238 QIQDEKAILDAVKSGKLAGAAIDVFNNEKAYLF--KTFDKIEDPVIAELLDLWPRVIMSP 295 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H + T EA T++ + +L NL + C N+L Sbjct: 296 HIGWYTQEAATNMLEISLDNLKEYVETGDCKNKL 329 >UniRef50_C9BJM5 D-isomer specific 2-hydroxyacid dehydrogenase n=17 Tax=Bacteria RepID=C9BJM5_ENTFC Length = 339 Score = 171 bits (433), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 102/328 (31%), Positives = 182/328 (55%), Gaps = 7/328 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A Y + + + +++N + ++L ++ LLT +A +AV + N Sbjct: 1 MRIACYGVRPNEIDFFEKLN-IYHYDLSLYEELLTHDNIVSAKDHDAVLLRGNCIADETN 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L +++++G++Y+ R G N++DL AA + G+ V RVP+Y P A+AE ++ M L R Sbjct: 60 LAKMQEYGIRYVFTRTVGVNHIDLQAAADFGMTVARVPSYSPNAIAELSLTFAMMLLRNT 119 Query: 121 HRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 RT +F + E + + T G+IGTG+IG+ + KG G +++ +D + + Sbjct: 120 AYTTIRTSFKDFRVDEQMFSREIRNCTVGIIGTGRIGLTEAVLFKGLGAKVIGYDIHQTE 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA ++ + + L L ++SD++S+H P P EN ++NE QMK G +++NT+RG L Sbjct: 180 AAKKV-LTFHSLEELLAKSDIVSIHVPHIPGENDQMINEGFLAQMKKGSILINTARGELQ 238 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFED-KSNDVIQDDVFRRLSACH-NVLFTGHQ 296 D++A + ALK+ + DV+ NE ++FF K + I D ++L + VL T H Sbjct: 239 DNEAILRALKSNHLAGFATDVFANETEVFFRSFKPWETIPDPAIQQLVEMYPRVLVTPHV 298 Query: 297 AFLTAEALTSISQTTLQNLSN-LEKGET 323 T EAL+++ T+ +N +E G+T Sbjct: 299 GSNTDEALSNMISTSFENFREIIETGKT 326 >UniRef50_A5VJC4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Lactobacillus reuteri RepID=A5VJC4_LACRD Length = 330 Score = 171 bits (432), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 101/325 (31%), Positives = 170/325 (52%), Gaps = 3/325 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFG-FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ +Y Q + Y+++ E ++ LL E T + G + V +F S Sbjct: 1 MKIYMYGVYQDEVPYIKEWQEEHPEVTVDSTTKLLDESTVNLSKGSDGVVVFQQKPYSDE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 L +L +G+ ++LR G +N++ + +ELG ++ VP Y P A+AE ++ + L RR Sbjct: 61 ALRQLALNGITKMSLRNVGVDNLNHELVQELGFQITNVPVYSPAAIAEFSVTQALNLLRR 120 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 Y + +++ M + G++GTG IG +I GFG +++A+ + + Sbjct: 121 TKEFYLKLAKGDYNWAPHIAKEMNKQVVGIVGTGNIGSTAAKIFAGFGAKVIAYSRHQNK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LE VEYV L L+ + +ISL+ P P +LNE F M++GV++VNT+RG L+D Sbjct: 181 E-LEGIVEYVSLDELYKRATIISLYLPHVPATDKMLNEKTFAMMQDGVLLVNTARGPLVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A IEAL + K+G +DV E +F + + D F+ L NVL T H AF Sbjct: 240 EKALIEALNSGKVGGAALDVMTGETKIFNRQINFQEVDYDEFKDLVDRPNVLITPHIAFY 299 Query: 300 TAEALTSISQTTLQ-NLSNLEKGET 323 T +A+ ++ + +L NL ++ G + Sbjct: 300 TDQAIKNMVKMSLSANLDLIKTGTS 324 >UniRef50_C2EUZ1 D-lactate dehydrogenase n=4 Tax=Lactobacillus RepID=C2EUZ1_9LACO Length = 339 Score = 170 bits (431), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 104/331 (31%), Positives = 169/331 (51%), Gaps = 4/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP- 59 MKL ++ + Y ++ G E++ LT T G + + + P Sbjct: 8 MKLIMFGVDDKEVPYAKEWATKTGNEVKLVREQLTTSTIDLVEGFDGISVLQTSKIDDPA 67 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + +LK+ G+K ++ R AGF+ DL+ AK+ GLK+ V Y P A+AE + M L RR Sbjct: 68 IYTKLKQFGIKQLSTRTAGFDMFDLELAKKNGLKITNVSIYSPRAIAEMGLTHAMYLLRR 127 Query: 120 IHRAYQR-TRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 I +R DA+F + L +Y +T ++G G IG A +I K G R++A Sbjct: 128 IGEFKERMVNDADFRWSKDLVSNEIYNQTVAIVGLGHIGGATAQIYKALGARVIAVTRET 187 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 S +VDL T E+D+I+LH PLT ++ F+QMKN +++N +RG + Sbjct: 188 SVVYAPYVDAFVDLETALKEADIITLHVPLTSSTENMFAAPQFKQMKNNAILINMARGQV 247 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +++ I ALKN +I G+D +E F + S + D F+ L A NV+ T H A Sbjct: 248 VNTNDLIAALKNHEIAGAGLDTLGDETTYFSKKVSPADVPAD-FKELVAMPNVVVTPHVA 306 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F+T A+ ++ Q +L +++ + KG+ NE+ Sbjct: 307 FMTTTAVRNMVQVSLNDIAAIVKGKNIKNEI 337 >UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina RepID=Q46AE6_METBF Length = 323 Score = 170 bits (430), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 96/262 (36%), Positives = 149/262 (56%), Gaps = 16/262 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ +++ G++++DL AA E G+ V VP Y ++VAE + + L R++H A R R Sbjct: 66 LQMLSVWQTGYDHIDLKAATEKGVIVSNVPDYAFDSVAEMVFALALNLLRKVHVADIRLR 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVE 187 + NF G + GKT GVIGTG IG +++I GF M +++ +PS A LGV+ Sbjct: 126 EGNFDWRHYFGSQIMGKTMGVIGTGSIGSRVIQIAHGFNMNVISVTGHPSEEKARSLGVK 185 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 +VDL TL +E+D+++LH PLTP ++ +MK +++NT+RG ++D A IEAL Sbjct: 186 FVDLDTLLAEADIVTLHVPLTPSTEKMIGAKELAKMKKSAILINTARGKVVDEAALIEAL 245 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K +KI G+DV+E E +ND L A NV+ T H AFLT E+L Sbjct: 246 KEKKIRGAGLDVFEKE-----PLPAND--------PLKALENVVLTPHIAFLTEESLEEC 292 Query: 308 SQTTLQNLSNLEKGETCPNELV 329 + +QN+ +G+ P +V Sbjct: 293 TYVCVQNVERFIEGK--PQNIV 312 >UniRef50_Q036G7 Lactate dehydrogenase related 2-hydroxyacid dehydrogenase n=5 Tax=Lactobacillales RepID=Q036G7_LACC3 Length = 330 Score = 169 bits (429), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 98/287 (34%), Positives = 152/287 (52%), Gaps = 6/287 (2%) Query: 38 TAKTANGCEAVCIFVNDDGSRP---VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKV 94 T A G + V I G+ P V ++LK G+K + LR G++ V+LDAA GL V Sbjct: 39 TVDLAKGYDGVVI--QQHGAIPDEMVYQKLKAFGIKQLTLRITGYDIVNLDAATANGLVV 96 Query: 95 VRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGK 154 VPAY P +V+E + +M L R + A R ++SL GL ++ T G+IG GK Sbjct: 97 TNVPAYSPRSVSELVLAQVMRLIRHLGEASAREAKDDYSLAGLEAPEIHNLTVGIIGAGK 156 Query: 155 IGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHL 214 IG A+ RI + G ++ DP L V YVDL TL + SDV+++H PL HL Sbjct: 157 IGSAVARIFRALGATVIVSDPV-KRPELADTVSYVDLNTLLTTSDVVTVHTPLDGLTTHL 215 Query: 215 LNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSND 274 ++ A +MK ++N +RG ++D++A I+AL + I +D E E +F ED+S Sbjct: 216 IDADALRKMKPTAYLINAARGPIVDTEALIKALNDHTIAGAALDTIEGEAGIFGEDRSQT 275 Query: 275 VIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 ++ + L A NV + H F T A+ ++ +L ++ + +G Sbjct: 276 LVDNQALETLKAMPNVEISPHIGFYTDAAVKNMIDISLDDVKTILEG 322 >UniRef50_C5NVX3 D-lactate dehydrogenase n=2 Tax=Bacilli RepID=C5NVX3_9BACL Length = 332 Score = 167 bits (424), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 100/316 (31%), Positives = 168/316 (53%), Gaps = 4/316 (1%) Query: 1 MKLAVYSTKQYDKKYLQQV-NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MKL ++ ++ +K L+ N E++ + LT G E V + N R Sbjct: 1 MKLVFFNLREDEKSALESWRNAHPEVEIDVYTEELTSANKHLLEGKEGVVLAQNKPFERD 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V E K+ GVK A R AGF+ DL+ E G+K+ VP+Y P A+AEH + + ++R Sbjct: 61 VYEYAKEQGVKVFATRSAGFDIYDLELMSEFGIKMTNVPSYSPNAIAEHVLTSALRISRN 120 Query: 120 IHRAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 ++ + NFS G+ + T GVIGTG+IG R+ G ++L +D Y + Sbjct: 121 TNKIQRNLEKHNFSWNPGILSRELRTLTVGVIGTGRIGTQAARLFSALGSKVLGYDVYQN 180 Query: 179 AAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 AA E+ + YV+ L L + SD+I++H P E H++N+ +MK+ +++N +RG L Sbjct: 181 EAAKEV-LRYVENLDDLIAASDIITIHMPAIKEYNHMVNDEFLAKMKDNSILLNAARGML 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D++A + AL + K+ G+DVYENE ++ D++ + L +V++T H A Sbjct: 240 VDTKAVLRALDSGKLLGAGLDVYENEGKYVPKNFEGKEFDDELLQTLIDRDDVIYTPHTA 299 Query: 298 FLTAEALTSISQTTLQ 313 F T A+ ++ + L+ Sbjct: 300 FYTETAIQNLVEGGLE 315 >UniRef50_C8P020 D-lactate dehydrogenase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P020_ERYRH Length = 331 Score = 167 bits (424), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 97/264 (36%), Positives = 147/264 (55%), Gaps = 4/264 (1%) Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 LK +G+K IA R AGF+ DLD A E GL + VP+Y PE++AE ++ ++L R++ Sbjct: 65 LKGYGIKQIAQRSAGFDYYDLDLATENGLIITNVPSYSPESIAEFSVTSALSLIRKLRVI 124 Query: 124 YQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 ++TR +F + + + T GV+GTG IG + FG ++LAFD Y + A Sbjct: 125 EEKTRQHDFRWQPQIRAGLLKEMTVGVVGTGHIGRKSAELFSAFGAKVLAFDVYQNEEAK 184 Query: 183 ELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 + V YVD + L S SDV+SLH P T +N+H N F + K +N +RG+++D++ Sbjct: 185 QY-VTYVDSVEELVSMSDVVSLHVPATKDNHHQFNAEMFRKFKPNAYFINAARGSVVDTK 243 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A IEAL + +D YENE +D SN I+D++F + +LFT H A T Sbjct: 244 ALIEALNQGHLAGAALDTYENESPFIPKDFSNQTIEDELFLEVLNHEKILFTPHIAHYTD 303 Query: 302 EALTSISQTTLQN-LSNLEKGETC 324 ++ +I + L + L LE G T Sbjct: 304 VSVRNIMEFALTSVLEILETGTTA 327 >UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=cellular organisms RepID=A5IMH3_THEP1 Length = 308 Score = 167 bits (422), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 94/247 (38%), Positives = 140/247 (56%), Gaps = 13/247 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G +N+D+ AKE G+K++ P +VAE A+G+M+ R I RA + Sbjct: 69 LKIIARAGIGLDNIDVQKAKEKGIKILNTPGASAPSVAELAMGLMLACARHIARATISLK 128 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 + + + L G + GKT G+IG G IG + + FGM+++A+DP + A +L VEY Sbjct: 129 EGKWEKKALNGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDP--AKPATDLPVEY 186 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 VDL TLF ESD ISLH PLT H++N + +MK+GV+IVNT+RG ID +A EAL Sbjct: 187 VDLDTLFRESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGTIDEEALYEALV 246 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 + K+ + G+DV+E E D++ R+L NV+ T H T EA + Sbjct: 247 SGKVYAAGLDVFEVEPP-----------TDEIRRKLLNLDNVVATPHIGASTDEAQNRVG 295 Query: 309 QTTLQNL 315 ++ + Sbjct: 296 TELVEKI 302 >UniRef50_C1DWX6 Glyoxylate reductase (Glycolate reductase) n=6 Tax=Aquificales RepID=C1DWX6_SULAA Length = 342 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 101/332 (30%), Positives = 180/332 (54%), Gaps = 13/332 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELE--FFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK+ + + +++ YL++ + G +++ F L + + +F+ ++ Sbjct: 1 MKVHFFEVEDWERLYLEKKIKDMGLDVDLGFTKEPLDDTNVDLYKDIDVAIVFIYSKLNK 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 VL +++ +K I R G++++D++ + G+ V VP Y VAE+ +++ L R Sbjct: 61 DVLSKMQ--NLKLIITRSTGYDHIDVEYTSKNGITVCNVPGYGNNTVAEYTFALILALAR 118 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + +RT FS +GLTG + GKT GVIG G+IG ++RI GFGM++L +D Y Sbjct: 119 KFKPMIERTSKGIFSRDGLTGIDLMGKTIGVIGAGRIGKHVIRIAYGFGMKILVYDRYKD 178 Query: 179 AAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 ++ G EYV L L SD+++LH P +HL+N+ + MK M++NTSRG + Sbjct: 179 QELIDKYGAEYVGLEDLLRMSDIVTLHVPYNKSTHHLINKFNIKLMKLDAMLINTSRGPV 238 Query: 238 IDSQAAIEALKNQKI-GSLGMDVYENERDLFFED--KSNDVIQDDVFRRLSACH-----N 289 ++ +A ++ALK ++ G +G+D +E E L E+ K +D+ + + L + + N Sbjct: 239 VEMEAIVQALKEGRLAGGVGLDTFEAEEVLIEEEYLKRDDIPAIKLKKALESFYVLHSEN 298 Query: 290 VLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 V+ + H A+ T +AL I TL NL + +G Sbjct: 299 VIVSPHNAYNTKDALYRILDITLDNLKSYLEG 330 >UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YY17_METPS Length = 326 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 95/258 (36%), Positives = 144/258 (55%), Gaps = 14/258 (5%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + G+K IAL G++NVDL AA G+ V V Y + VAE A + + L R++ +A Sbjct: 62 RAPGLKMIALWQTGYDNVDLAAATARGVVVSNVHNYAFDTVAEFAFALALNLLRKVDKAD 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 R F G + GKT GVIG G IG +++I GF M +L+ +P A Sbjct: 122 LNLRRGLFDWRRYVGEELMGKTLGVIGLGSIGRRVVQIAHGFNMSVLSVTAHPDPERARA 181 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LGV++V L TL +ESDV+SLH PLTPE H++ A +MK +++NT+RG ++D +A Sbjct: 182 LGVKFVSLDTLLAESDVVSLHVPLTPETEHMIGAAQLARMKPTAILINTARGKIVDEKAL 241 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +EAL+ ++I G+DV+E E + D +L NV+ T H AFL+ E+ Sbjct: 242 VEALREKRIAGAGLDVFETE----------PLPMDSPLLKLD---NVVLTPHIAFLSKES 288 Query: 304 LTSISQTTLQNLSNLEKG 321 + ++ T++N+ KG Sbjct: 289 IDECTRVTMENVEMFVKG 306 >UniRef50_P63940 D-lactate dehydrogenase n=61 Tax=Bacilli RepID=LDHD_STAAM Length = 330 Score = 162 bits (411), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 97/328 (29%), Positives = 163/328 (49%), Gaps = 2/328 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + T+ Y+K+ + E+ LL+ T + V V Sbjct: 3 KIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +L+ +G+K IA R AGF+ DLD AK+ + + VP+Y PE +AE+++ + + L RR Sbjct: 63 PKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFP 122 Query: 122 RAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R + +F+ + + + T +IGTG+IG A +I GFG + A+D YP+ Sbjct: 123 DIERRVQTHDFTWQAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKD 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 L+ + ++D+ISLH P E+YHL ++A F+ +K G ++VN +RGA+I++ Sbjct: 183 -LDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVINT 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 I A+ + + +D YENE F D +N I D L +L T H AF + Sbjct: 242 PDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFS 301 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA+ ++ + L ++ TC L Sbjct: 302 DEAVQNLVEGGLNAALSVINTGTCETRL 329 >UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellular organisms RepID=SERA_ARCFU Length = 527 Score = 160 bits (406), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 96/299 (32%), Positives = 159/299 (53%), Gaps = 16/299 (5%) Query: 24 GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVD 83 G E+E + E+ + EA+ + V++ K +K I G +N+D Sbjct: 21 GLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQAAKN--LKIIGRAGVGVDNID 78 Query: 84 LDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMY 143 ++AA + G+ VV P + + AEHAI +M+ R+I +A + ++ + + G + Sbjct: 79 INAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQADRSVKEGKWERKKFMGIELR 138 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVIS 202 GKTAGVIG G++G + + K M +LA+DP+ S A ++GV+ VD TL + SDVI+ Sbjct: 139 GKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERAEQIGVKLVDFDTLLASSDVIT 198 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 +H P T E L+ + FE+MK+GV++VN +RG ++D A EA+K K+ + +DVYE Sbjct: 199 VHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEAALYEAIKAGKVAAAALDVYEK 258 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 E N +++ D NV+ T H A T EA ++ +++ N+ KG Sbjct: 259 EPP----SPDNPLLKLD---------NVVTTPHIAASTREAQLNVGMIIAEDIVNMAKG 304 >UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 Tax=Bacteroides coprophilus DSM 18228 RepID=UPI000197AFFA Length = 315 Score = 160 bits (406), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 95/257 (36%), Positives = 142/257 (55%), Gaps = 15/257 (5%) Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 KH +K+I + G ++VDLDAA+E G+KV Y +AVAE A+ MM++L R + + Sbjct: 68 KH-LKFIDVAFTGVDHVDLDAARECGVKVSNAAGYSTQAVAELALCMMLSLLRNVPQVAG 126 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELG 185 R R + +GL G + GKT G++G G IG + K FG R+L + + Sbjct: 127 RCRQGK-TKDGLVGCELRGKTVGIVGAGAIGTRTAELCKAFGCRVLGNKRHLTGKEPSF- 184 Query: 186 VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 +E++ L L S+SD++SLHCPLT E L+N MK G ++NT+RG ++DS A E Sbjct: 185 IEFMPLEELLSQSDIVSLHCPLTAETRQLINADRLGMMKQGAYLINTARGGVVDSAALAE 244 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 ALKN + G+DV+E E L D ++ ++Q NVL T H AF + E++ Sbjct: 245 ALKNGYLAGAGIDVFETEPPL---DPAHPLLQ---------APNVLATPHVAFASEESME 292 Query: 306 SISQTTLQNLSNLEKGE 322 + + NLSN G+ Sbjct: 293 ARAAIVFSNLSNWMDGK 309 >UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CRA6_9FIRM Length = 321 Score = 160 bits (405), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 91/258 (35%), Positives = 144/258 (55%), Gaps = 17/258 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I+ G++ +D+ AA + G+ V P + +AV E A G+++++ R+I + TR Sbjct: 73 LKVISRYGTGYDRIDMAAASQYGVTVTNTPGVNAQAVGELAFGLLLSVARQISYLDRTTR 132 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVE 187 + G + GKT G++G G IG + R KGFGMR+ A DP+ E G+E Sbjct: 133 SGEWVRA--EGVELKGKTLGILGLGAIGKVVARCAKGFGMRVAASDPFIDREYCREHGIE 190 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 +D+ L S +D +SLH PL E HL+ + A +MK+GV+++NTSRG +ID +AA L Sbjct: 191 AMDMEDLLSFADAVSLHLPLNKETTHLIGKEALARMKDGVILINTSRGGIIDEEAAYCGL 250 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K+ KIG LG+D +ENE K + + + NV+ T H T EA + + Sbjct: 251 KSGKIGGLGLDAFENE-----PPKGSSLFE---------FSNVVATPHTGAHTKEAASMM 296 Query: 308 SQTTLQNLSNLEKGETCP 325 ++ + NL ++ +GE CP Sbjct: 297 AERAVDNLISVLQGERCP 314 >UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Archaea RepID=SERA_METTH Length = 525 Score = 159 bits (403), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 85/219 (38%), Positives = 128/219 (58%), Gaps = 3/219 (1%) Query: 46 EAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAV 105 +A+ + +R V+E + +K IA G +NVD+ AA + G+ V+ P V Sbjct: 45 DAIVVRSRTKVTREVIEAAPR--LKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITV 102 Query: 106 AEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKG 165 AEH+IG+M+ L R+I A + ++ + G + GKT G+IG G+IG ++ K Sbjct: 103 AEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKA 162 Query: 166 FGMRLLAFDPYPSA-AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMK 224 FGM ++ +DPY S AA E+GV DL TL ESD++++H PLTPE HL++E F+ MK Sbjct: 163 FGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMK 222 Query: 225 NGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 + IVN +RG +ID A ALK+ +I +DV+E E Sbjct: 223 DTAFIVNCARGGIIDEDALYRALKDGEIAGAALDVFEEE 261 >UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms RepID=A7HM61_FERNB Length = 317 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 93/247 (37%), Positives = 139/247 (56%), Gaps = 10/247 (4%) Query: 25 FELEFF---DFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNN 81 FE++ + +FL E+ K A +A+ + D + + LKK K IA G+NN Sbjct: 21 FEVDVYTGEEFLSKEEMIKRAEYADAIVTQLRDPIDKEFIYSLKK--AKIIANYAVGYNN 78 Query: 82 VDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANF---SLEGLT 138 +D++AAKE G+ V P EA A+ A +++ + RRI + + R+ F + Sbjct: 79 IDIEAAKERGIYVTNTPGVLTEATADIAFALILAVARRIVESDKFVREGKFVGWKPKLFL 138 Query: 139 GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP--YPSAAALELGVEYVDLPTLFS 196 G+ +YGKT GVIG G+IG A+ R GFGM ++ ++ P + +YV++ L Sbjct: 139 GYDLYGKTLGVIGMGRIGQAVARRALGFGMNIVYYNRNRLPEEIEKQYNAKYVNIDELVE 198 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 SD ISLH PLT E YHL+N+ +MK ++VNT+RG ++D QA EALK ++I G Sbjct: 199 ISDYISLHTPLTKETYHLINKERIAKMKPNAILVNTARGPVVDEQALYEALKERRIAGAG 258 Query: 257 MDVYENE 263 DVYENE Sbjct: 259 FDVYENE 265 >UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=5 Tax=Archaea RepID=A3DM01_STAMF Length = 311 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 87/245 (35%), Positives = 141/245 (57%), Gaps = 5/245 (2%) Query: 22 SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNN 81 S GF++ + ++ ++ + EA+ + SR V+E +K +K IA G +N Sbjct: 20 SAGFQIVYEEYPSEDRLVELIKDVEAIIVRSKPKVSRRVIEAAEK--LKVIARAGVGLDN 77 Query: 82 VDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFT 141 +DLDAA E G++V PA ++VAE AIG+M+ + R+I A ++ R+ ++ + G Sbjct: 78 IDLDAANEKGIQVFNAPAAPTQSVAELAIGLMIDVLRKIAFADRKMREGVWAKKQCLGHE 137 Query: 142 MYGKTAGVIGTGKIGVAMLRI-LKGFGMRLLAFDPY--PSAAALELGVEYVDLPTLFSES 198 + G G+IG G+IG A+ RI GFGM+++ +D P EL + VDL TL + Sbjct: 138 LRGIVLGIIGMGRIGTAVARIAYHGFGMKIIYYDVRRCPKDVEKELDAKCVDLETLLKTA 197 Query: 199 DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMD 258 D++S+H PL P HL+NE MK +++NT+RG ++D+ A ++ALK I G+D Sbjct: 198 DIVSIHVPLVPSTKHLINEEKLRLMKKSAILINTARGGVVDTDALVKALKEGWIAGAGLD 257 Query: 259 VYENE 263 V+E E Sbjct: 258 VFEEE 262 >UniRef50_B1L1I5 D-lactate dehydrogenase n=16 Tax=Clostridium RepID=B1L1I5_CLOBM Length = 334 Score = 158 bits (399), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 106/335 (31%), Positives = 169/335 (50%), Gaps = 9/335 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIF-VNDDGSR 58 MK+ +YS ++++K +++ E+ G +++ + L+E T A + + I N G + Sbjct: 1 MKILMYSVREHEKPAIKKWLEANPGVQIDLCNEALSEDTVCKAKEYDGIAIQQTNSIGRK 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V LK++G+K IA R AG + +DL A + + V VPAY P A+AE A+ M L R Sbjct: 61 DVYSILKEYGIKQIASRTAGVDMIDLKMASDSNILVTNVPAYSPNAIAELAVTHTMNLLR 120 Query: 119 RIHRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 I +R ++ L + T GV+GTGKIG ++ KG G ++ +D YP Sbjct: 121 NIKTLNKRIAYGDYRWSADLIAREVRSITVGVVGTGKIGRTSAKLFKGLGANVIGYDAYP 180 Query: 178 SAAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 E L L L E+DV++LH PL +++N+ + MK IVNT RG Sbjct: 181 DKKLEENNLLTYKESLEDLLREADVVTLHTPLLESTKYMINKNNLKYMKPDAFIVNTGRG 240 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQ--DDVFRRLSACHNVLFT 293 +I+++ IEAL+ KI +D +ENE F +K D + D +L VL T Sbjct: 241 GIINTEDLIEALEQNKIAGAALDTFENEG--LFLNKVVDPTKLPDPQLDKLLKMDQVLIT 298 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H F T A+ +I T+L ++ + K N++ Sbjct: 299 HHVGFFTTTAVQNIVDTSLDSVVEVLKTNNSVNKV 333 >UniRef50_B2KDH0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KDH0_ELUMP Length = 338 Score = 156 bits (394), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 93/263 (35%), Positives = 142/263 (53%), Gaps = 11/263 (4%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K+I++R GF+ +D KE ++V VP Y VAE+ IGM+ L R I RA + Sbjct: 69 LKFISVRSTGFDAIDTTYCKEKSIRVFNVPRYGETTVAEYTIGMIFALTRNIVRANNDMK 128 Query: 129 DAN-FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVE 187 D N ++ + + T GV+G G IG +++ + GM ++A+DPYPS ++ Sbjct: 129 DRNQLDIKSYSSRDLEAWTLGVLGAGAIGRSVINKAQCLGMNVIAYDPYPSKDFP--NIK 186 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 YV L L SD+ISLH P T ENYH++ E F++MK GV I+NT+RG LID++A AL Sbjct: 187 YVSLEELIKNSDIISLHVPSTKENYHMIGEENFKKMKKGVYIINTARGDLIDNKALYGAL 246 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQ---DDVF-----RRLSACHNVLFTGHQAFL 299 + + +DV E E + +D + Q +++F +L NV+ T H AF Sbjct: 247 LSGHVAGTALDVLEEEGLMVGDDTLGMLAQRTKEELFTYSINTKLMNLDNVIVTPHIAFD 306 Query: 300 TAEALTSISQTTLQNLSNLEKGE 322 T +A I T +N++ E Sbjct: 307 TLDARKRIMTQTCKNIAGYYNAE 329 >UniRef50_B4RIC5 D-lactate dehydrogenase n=1 Tax=Phenylobacterium zucineum HLK1 RepID=B4RIC5_PHEZH Length = 338 Score = 155 bits (391), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 103/286 (36%), Positives = 158/286 (55%), Gaps = 12/286 (4%) Query: 46 EAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAV 105 + + FVN D S VL + ++ IA R G++++DLD ++ + V VP Y + V Sbjct: 44 QVISPFVNSDLSATVLRRFPR--LELIATRSTGYDHIDLDYCRQHKVTVCNVPDYGDQTV 101 Query: 106 AEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKG 165 AEHA +++ L R + A R R ANFS +GL GF + GK GV+G G+IG ++ I +G Sbjct: 102 AEHAFALLLALIRHVPEASARARQANFSQQGLRGFELAGKVMGVVGVGRIGRRVIAIARG 161 Query: 166 FGMRLLAFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMK 224 FGM ++A+D P A A+ LG Y L + + +DV+SLH P + L+++A F +MK Sbjct: 162 FGMDVVAYDRAPDAEAVRTLGFRYAPLNEVLATADVLSLHVPGGAGSRSLISDAEFGRMK 221 Query: 225 NGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFED---KSNDVIQDDVF 281 G ++VNT+RG ++D+QA + AL + ++ +DV ER + E + + Sbjct: 222 PGAILVNTARGGVVDAQALVRALHSGRLAGAALDVIAQERRMRDEAEIFRERLTPSPESL 281 Query: 282 RRLSACH------NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 + L A H NVL T H A+ T EA+ I TTL N+ G Sbjct: 282 QALLADHALLHMPNVLVTPHIAYNTEEAVHRIIDTTLANILAFAHG 327 >UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMC8_9FIRM Length = 530 Score = 155 bits (391), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 87/255 (34%), Positives = 134/255 (52%), Gaps = 13/255 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G + +D+ A G+ VV P + A EH + +M+++ R I +A+Q Sbjct: 64 LKVIGRAGVGIDGIDIPEATAKGITVVNTPESNTIAACEHTLALMLSITRYIPQAHQSIM 123 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVE 187 + + + TG + KT G+IG G++G + + L+ F M+ + +DPY P +LGV+ Sbjct: 124 EGRWDRKSFTGIQLLNKTVGIIGVGRVGSNVAKRLQAFNMKTIGYDPYIPLERGQQLGVD 183 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 VDL TL ESD I+LH PLT E ++ E+MK+GV IVN SRGA+ID A EAL Sbjct: 184 LVDLDTLLRESDYITLHTPLTEETKGMIGAKEIEKMKDGVRIVNASRGAVIDIDALAEAL 243 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K K+ G+DV+ NE + ++N + NV T H T EA T + Sbjct: 244 KTGKVAGAGIDVWTNEP---LKPENNPFL---------GMKNVTLTPHLGASTVEAQTGV 291 Query: 308 SQTTLQNLSNLEKGE 322 + + +++ GE Sbjct: 292 ATDVARGVADALHGE 306 >UniRef50_Q98LH4 Phosphoglycerate dehydrogenase n=2 Tax=Mesorhizobium loti RepID=Q98LH4_RHILO Length = 341 Score = 154 bits (390), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 112/335 (33%), Positives = 175/335 (52%), Gaps = 39/335 (11%) Query: 4 AVYSTKQYDKK-----YLQQ--VNESFG---FELEFFDFLLTEKTAKTANGCEAVCIFVN 53 +V + ++YD +L++ VN FG +E+ F F E AK A+GC A+ Sbjct: 8 SVLAFERYDPTDASLDWLRERGVNVIFGNALWEMPFKRFTEDELIAK-AHGCIALMGASG 66 Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA-YDPEAVAEHAIGM 112 +R V++ L ++YI+ G +++D+DAA E G+ V P + V+EHA+ + Sbjct: 67 TRITRRVMQALPD--LRYISKYGIGVDSIDIDAATEHGILVSSTPNDFQIFTVSEHAVAL 124 Query: 113 MMTLNRRIHRAYQRTRDANF----SLEGLT-GFTMYGKTAGVIGTGKIGVAMLRILKGFG 167 M+ + +++ T F GLT G T+ G T G++G G+IG + + L G+ Sbjct: 125 MLAVAKQLG-----TWTPEFMRRGGWRGLTHGATLRGATVGIVGLGRIGRGVAQRLSGWE 179 Query: 168 MRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGV 227 R+LA+DP+ A G+E VD PTL +SD ++LH +P+N+H+LN AAF +MK Sbjct: 180 ARILAYDPFLKEA--PPGIELVDFPTLVEQSDFLTLHATPSPDNHHILNAAAFAKMKPSA 237 Query: 228 MIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC 287 ++VNT RG+LID A AL N +I +DV++ E K++D L + Sbjct: 238 IVVNTGRGSLIDYTALRAALANGQIAGAALDVFDQE-----PPKTDD--------PLFSL 284 Query: 288 HNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 NVL T H A T E +I +NL + GE Sbjct: 285 PNVLCTPHVAAWTTEGTQAIGWHAAKNLWAMMSGE 319 >UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=B8HPZ0_CYAP4 Length = 652 Score = 154 bits (388), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 93/251 (37%), Positives = 131/251 (52%), Gaps = 14/251 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +NVD+ AA G+ VV P + A AEH + MM++L+R I A Q + Sbjct: 190 LKIIGRAGVGVDNVDVPAATRKGIVVVNSPEGNTIAAAEHTLAMMLSLSRHIPAASQSVK 249 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALELGVE 187 + + TG +Y KT GVIG GKIG + + + GM LLA+DPY S A ++G Sbjct: 250 SGKWDRKSFTGVEVYKKTLGVIGLGKIGSHVATVARAMGMNLLAYDPYLSNERAEQIGCR 309 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V+L LF+E+D I+LH P TPE HL+ +MK I+N +RG +ID A +EAL Sbjct: 310 LVNLDLLFAEADYITLHLPKTPETQHLIKAETLARMKPTARIINCARGGIIDEAALVEAL 369 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K KI +DV+ENE E LS V+ T H T EA T++ Sbjct: 370 KEGKIAGAALDVFENEP--LGESP-----------LLSLGKEVVLTPHLGASTEEAQTNV 416 Query: 308 SQTTLQNLSNL 318 + + + +L Sbjct: 417 AIDVAEQIRDL 427 >UniRef50_Q99ZM2 D-lactate dehydrogenase n=16 Tax=Bacilli RepID=LDHD_STRP1 Length = 330 Score = 154 bits (388), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 98/317 (30%), Positives = 167/317 (52%), Gaps = 9/317 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVC---IFVNDDGS 57 MKL +Y+ + + ++ + G E+ + LT +T K A G + + I DD Sbjct: 1 MKLKLYNVRGEEAVLAKKWADDNGIEISLTESPLTPETVKEAEGFDGIANAQIGPLDDAI 60 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 P+L+E+ G+K IA A + +LD A E + + VP+Y PE++AE + +++ L Sbjct: 61 YPLLKEM---GIKQIAQHSASVDMYNLDLATENDIIITNVPSYSPESIAEFTVTIVLNLI 117 Query: 118 RRIHRAYQRTRDANFSLEGLT--GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R + + + NF+ GL G + T +IGTG+IG+A +I KGFG +++ +D Sbjct: 118 RHVELIRENVKKQNFTW-GLPIRGRVLGDMTVAIIGTGRIGLATAKIFKGFGCKVVGYDI 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 Y S AA + + ++D++SLH P T EN HL N F+ K G +++N +RG Sbjct: 177 YQSDAAKAVLDYKESVEEAIKDADLVSLHMPPTAENTHLFNSDLFKSFKKGAILMNMARG 236 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 A+I++Q ++AL + G+D YE E ++ I D +F+ L V++T H Sbjct: 237 AVIETQDLLDALDAGLLSGAGIDTYEFEGPYIPKNFEGQEITDSLFKALINHPKVIYTPH 296 Query: 296 QAFLTAEALTSISQTTL 312 A+ T EA+ ++ + L Sbjct: 297 AAYYTDEAVKNLVEGAL 313 >UniRef50_Q047V3 Lactate dehydrogenase related 2-hydroxyacid dehydrogenase n=4 Tax=Lactobacillus RepID=Q047V3_LACDB Length = 348 Score = 153 bits (387), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 96/322 (29%), Positives = 160/322 (49%), Gaps = 6/322 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A Y + ++ Y +++N+ + ++L+ L + A C+AV + N R Sbjct: 1 MRIACYGVRPLERSYFEKLNK-YDYDLKLIPEYLNRENVVQAEDCDAVLVRGNCLCDRTN 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+ K +G+ ++ R G ++ DL+AAK+LG+ V RVP Y P AVA A + +TL+R + Sbjct: 60 LEQFKNYGISWVFTRSVGVDHFDLEAAKDLGISVARVPNYSPYAVANLAFTLGLTLSRHV 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGK-TAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 A + +F + T + + G+ G GKIG ++ + G + A+DP+PS Sbjct: 120 GEAAHHVHEHDFGMHPDYFATEFNRLKVGIYGAGKIGAVEGKMWQALGAEVYAYDPFPSD 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A + +V L + D++S+H P P EN L+N +MK G ++VNT+RG L Sbjct: 180 FAKQY-CTFVTEDELLATCDIVSVHVPYFPGENDKLMNAEFIAKMKEGAVLVNTARGELA 238 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFE--DKSNDVIQDDVFRRLSACHNVLFTGHQ 296 D A A+ + + G DV NE+ + D +DV +V + VL T H Sbjct: 239 DEAAIAAAVSSNHLSGYGADVVSNEKKIMGHNFDCESDVPDQEVQSLMDLYPRVLLTPHM 298 Query: 297 AFLTAEALTSISQTTLQNLSNL 318 T AL + + N N+ Sbjct: 299 GSFTEPALEDMISLSFNNFHNM 320 >UniRef50_A6Q114 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic component n=1 Tax=Nitratiruptor sp. SB155-2 RepID=A6Q114_NITSB Length = 314 Score = 153 bits (387), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 97/319 (30%), Positives = 164/319 (51%), Gaps = 17/319 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M +A++ + ++ QQ+ F + + + EK A EA+ IFV R V Sbjct: 1 MNIAIFEADKECQEVFQQLEAKIDFFTQDINHAVHEKKA-----YEAISIFVRSKIDRLV 55 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L ++YI R GF+++DL+ K+ G+ V V Y VAE A +++ ++R+ Sbjct: 56 LELLP--NLRYIQTRSTGFDHIDLEECKKRGIIVSNVQGYAGPPVAEFAFSLLLNISRKT 113 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF-DPYPSA 179 A R ++ +F + L GF ++ K+ G++G G IG M RI GFGM+ A+ + Sbjct: 114 DIAIARAKEGSFVYKDLLGFELFEKSIGIVGLGTIGKQMARIASGFGMKTKAYTHHFDET 173 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + +E L SDVI PLTP+ YH+L+ + ++ +++N +RG +I Sbjct: 174 FCKQYNIEKCSYEELLQTSDVIMFAVPLTPQTYHMLDIQKAKLLQPHAVVINVARGEVI- 232 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S+ AIE L + G +G+DV+E E++L S+ F +L N+ +T H A+ Sbjct: 233 SKEAIEYLSDHIYG-IGLDVFEGEKELLKNPMSD-------FLQLIQKSNIRYTPHMAYY 284 Query: 300 TAEALTSISQTTLQNLSNL 318 T EAL I + +++N+ Sbjct: 285 TKEALERIRKISVENMKRF 303 >UniRef50_A8Z3G0 (R)-2-hydroxyacid dehydrogenase n=67 Tax=Bacilli RepID=A8Z3G0_STAAT Length = 342 Score = 153 bits (386), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 97/329 (29%), Positives = 163/329 (49%), Gaps = 11/329 (3%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + S + D Y++ E E++ LT+ + G + + + S V Sbjct: 13 KIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEHVY 72 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + L + G+K IA R AGF+ DL+ A + V VP+Y P ++AE A+ + + R + Sbjct: 73 KRLNELGIKQIAQRSAGFDTYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRHFN 132 Query: 122 RAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 + + R+ +F E + ++ VIGTG+IG + I G+ ++A+DP+P+A Sbjct: 133 QIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRVVADIFANGYQSDVVAYDPFPNA 192 Query: 180 AALELGVEYVDLPTLFSES----DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 YVD E+ D+++LH P T N++L N F+ K G + VN +RG Sbjct: 193 KI----ATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARG 248 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +L+D++A ++AL N I +D YE ER LF D+ + D + L +V+ T H Sbjct: 249 SLVDTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPH 308 Query: 296 QAFLTAEALTSISQTTLQ-NLSNLEKGET 323 AF T A+ ++ L L L+ G+T Sbjct: 309 IAFYTEAAVKNLIVDALDATLDVLQTGDT 337 >UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHI0_ARCPR Length = 525 Score = 153 bits (386), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 88/271 (32%), Positives = 146/271 (53%), Gaps = 16/271 (5%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V++ KK +K I G +N+D+D A E G+ VV P + + AEH IG+++++ Sbjct: 54 TRDVIDRAKK--LKIIGRAGVGVDNIDVDYATEKGIVVVNAPGGNSVSAAEHTIGLILSI 111 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R+I +A + ++ + + G + GKT G++G G+IG + + ++ F M +LA+DPY Sbjct: 112 ARKIPQADRSVKEGKWERKKFVGIELRGKTLGIVGLGRIGYEVAKRMRCFEMNILAYDPY 171 Query: 177 PSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 S A +G + V L L SD+I++H P T E +++ FE MK+GV I+N +RG Sbjct: 172 VSEERAKSVGAKLVSLEELLRNSDIITIHVPKTKETEKMISYKEFEIMKDGVYIINAARG 231 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D +A +AL + K+ +DVYE E DK N +++ NV+ T H Sbjct: 232 GIVDEKALYDALVSGKVAGAALDVYEKEP----PDKDNPLLK---------LENVVTTPH 278 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 T EA + T +++ N KG N Sbjct: 279 IGASTREAQMMVGMTVAEDIVNFFKGLPVKN 309 >UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Archaea RepID=A8A9G4_IGNH4 Length = 308 Score = 152 bits (385), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 87/223 (39%), Positives = 133/223 (59%), Gaps = 6/223 (2%) Query: 43 NGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDP 102 G + + + R V+E K +K IA +G +N+DL+AAKE G+KVV P Sbjct: 42 KGFDVLIVRSRTKVRREVIEAADK--LKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALK 99 Query: 103 EAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRI 162 AVAE IGMM+ L RR H +Y++ + + E + GF + GKT GV+G G+IG + + Sbjct: 100 NAVAELVIGMMVVLARRAHYSYRKLLEGEW--EKVMGFELAGKTLGVVGFGRIGREVAKK 157 Query: 163 LKGFGMRLLAFDPYP-SAAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAF 220 K GM ++A+D S A E+GVE+ DL L +SDV+SLH PLT + +++N Sbjct: 158 AKALGMNVIAYDVVDLSETAKEMGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRI 217 Query: 221 EQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 + MK+G +++N +RG + D A +EAL++ K+ +G+DVY E Sbjct: 218 KIMKDGAILINAARGEVADYSALLEALESGKLWGVGLDVYPEE 260 >UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Bacteria RepID=Q2RH37_MOOTA Length = 329 Score = 152 bits (385), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 106/330 (32%), Positives = 159/330 (48%), Gaps = 21/330 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTE-KTAKTANGCEAVCIFVNDDGSRPV 60 K VY T+ + L + E E+ D +LT + + G + + + D V Sbjct: 3 KWNVYVTRLVPQPALDLLAEYCDLEINPEDRVLTRAELLEKVRGRDGILCLLTDILDDEV 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 K G K A GFNNVDL+AA G+ + P EA A+ A ++ + RR+ Sbjct: 63 FTAAK--GAKIFANLAVGFNNVDLEAATRHGIMITNTPGVLTEATADMAWALLFAVARRV 120 Query: 121 HRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + TR + G + G + GKT GVIG G+IG A R +GF M++L D P Sbjct: 121 VEGDKFTRAGKYKGWGPLLMLGQEITGKTLGVIGAGRIGTAFARKARGFDMKVLYHDVQP 180 Query: 178 SAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 S A E G ++VD TL E+D +SLH PL P HL++ + MK +++NTSRG Sbjct: 181 SKAFEEATGGQFVDKETLLKEADFVSLHVPLMPSTTHLISTPELKLMKKTAILINTSRGP 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D +A ++AL+ ++I G+DV+ENE +L L+ NV+ H Sbjct: 241 VVDEKALVKALREKEIWGAGLDVFENEPEL--------------APGLADLENVVLCPHI 286 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPN 326 A T E T+++ NL +GE P Sbjct: 287 ASATWETRTNMALMAANNLLAALRGELPPQ 316 >UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WVY8_ALIAD Length = 529 Score = 152 bits (383), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 90/268 (33%), Positives = 140/268 (52%), Gaps = 16/268 (5%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V+E KK +K I G +N+DL+AA G+ V+ P + A AEH MM++L Sbjct: 57 TRDVIESAKK--LKVIGRAGVGVDNIDLEAATRRGILVINAPDGNTIAAAEHTFAMMISL 114 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R I A++ N++ + G + GKT V+G G+IG + + K FGM +L +DP+ Sbjct: 115 ARHIPAAHRDLLQGNWNRKKWIGVELRGKTLAVLGMGRIGTEVAKRAKAFGMTVLGYDPF 174 Query: 177 -PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A LGV+ DL T E+D I++H PLT E +H+++ QMK GV I+N +RG Sbjct: 175 LTEERAQSLGVKRCDLDTAIREADFITVHTPLTKETHHMIDAGRIAQMKEGVRIINCARG 234 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +ID A EAL+ ++ +DV+E E + D RR C NV+ T H Sbjct: 235 GIIDEVALAEALEAGRVAGAAIDVFEQE----------PLPMDHPLRR---CPNVVLTPH 281 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGET 323 T EA +++ + + + + +T Sbjct: 282 LGASTVEAQENVAIQVAEEIVQVLRDDT 309 >UniRef50_C0WS24 D-lactate dehydrogenase n=6 Tax=Lactobacillus RepID=C0WS24_LACBU Length = 339 Score = 151 bits (382), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 97/333 (29%), Positives = 173/333 (51%), Gaps = 8/333 (2%) Query: 2 KLAVYSTKQYDKKYL-QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVND---DGS 57 K+ Y+ Y+++++ + E +++F L + T A G + + DGS Sbjct: 7 KILAYNILDYEREFVVEWAAEHPDVQVDFNSIELHDDTVHLAEGYDGIDYRQRSQLTDGS 66 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 + ++L +G+ +ALR AG ++ +L AKE GL V VP+Y P AVAE + M L Sbjct: 67 -DLYKKLHDYGIHQLALRSAGVDSCNLKYAKENGLTVTNVPSYSPRAVAEMTLTHAMNLI 125 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGM-RLLAFDPY 176 R I + +R R ++ + GL + T G+IG G+IG + +I K G R+L D Sbjct: 126 RHIPQFQKRIRQNDYVVNGLRSKEISNLTVGIIGVGRIGSTVAKIFKALGAKRVLGNDIK 185 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + +L V+Y ++ +D+I++H ++ +NYH++ + F +MKN + +N SRG Sbjct: 186 ENDDFRDL-VDYTTKEDIYKNADLITMHTYMSDQNYHMIGKDQFGKMKNTALFINCSRGP 244 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFED-KSNDVIQDDVFRRLSACHNVLFTGH 295 ++D+ A + AL+ +I G+DV ++E +F + D I V+ +L NV T H Sbjct: 245 IVDTDALVNALETGQIAGAGIDVIQDETKIFNQSFIGEDKIPLPVYTKLMNMDNVFLTPH 304 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 AF T A+ ++ + +L + G+ P+ + Sbjct: 305 VAFYTDHAVKNMVKQSLDDTLMEISGKESPHRI 337 >UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MD25_CALMQ Length = 326 Score = 150 bits (378), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 108/338 (31%), Positives = 169/338 (50%), Gaps = 36/338 (10%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFD---FLLTEKTAK--------TANGCEAVCIFVN 53 +Y T+ K L + GF+LE +D + ++ A A+ C+A+ + + Sbjct: 1 MYLTRSTFPKLLYDTLRNAGFDLEVWDNKGHGMWDRAAAPPRDVLRDAASRCDALVVTIG 60 Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 D VL K VK IA G++++DLDAA G+ V P EAVA+ AIG++ Sbjct: 61 DRVDDYVLSNAK---VKVIATYSVGYDHIDLDAATRRGIPVGYTPEVLVEAVADLAIGLI 117 Query: 114 MTLNRRIHRAYQRTRDAN-FSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 +TL RR+ + R + + G G ++GKT G++G G IG A+ R K F M ++ Sbjct: 118 ITLARRVIEGDRLVRSGEAYKVWGEFLGTEVWGKTLGILGLGNIGAAVARRAKAFNMNVI 177 Query: 172 AFD----PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGV 227 + P+ A LG+ YVDL LF +SD + L L+ E YH++NE MKN Sbjct: 178 YWSRTRKPWIEVA---LGLRYVDLNELFRQSDYLVLTVALSKETYHIVNEERLRLMKNTS 234 Query: 228 MIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC 287 +VN +RGA++D+ A ++ALK I +DVYE E ++++I+ Sbjct: 235 YLVNVARGAVVDTNALVKALKEGWIAGAALDVYEEEP----IPNTHELIK---------L 281 Query: 288 HNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 +NV+ T H A T E +++ T N+ N+ T P Sbjct: 282 NNVILTPHIASATVETRNKMAEVTALNVINVLLKNTKP 319 >UniRef50_B4D8A9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D8A9_9BACT Length = 382 Score = 149 bits (377), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 101/328 (30%), Positives = 167/328 (50%), Gaps = 28/328 (8%) Query: 20 NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGF 79 E + +L D + + + EA+ IF+N + LE + +++IA R Sbjct: 50 QEYYSDQLSAHDLRFVSQLGEVGDDAEAISIFINSRITSKFLETHPR--LRFIATRSTAI 107 Query: 80 NNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTG 139 ++ DL A +E + + V Y VAEH +++ L+RR+ + FS G Sbjct: 108 DHFDLPACRERQITISNVNDYGFTTVAEHTFALILALSRRLREVMLAPKGGAFSYAANRG 167 Query: 140 FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD-PYPSAAALELGVEYVDLPTLFSES 198 F + GKT G+IG G+IG + + F M +LA+D +P+ L ++V+L + E+ Sbjct: 168 FDLAGKTIGIIGMGRIGQRVAELAHAFRMTVLAYDIDHPTKLEQTLDFKFVELDEVLREA 227 Query: 199 DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMD 258 +++LH PLT E YH+LN F + + GV++VNT+RGALID+QA EAL + ++G G+D Sbjct: 228 QILTLHAPLTAETYHILNRQTFAKCRPGVLVVNTARGALIDAQALREALDSGQVGGAGLD 287 Query: 259 VYENERDL---FFEDKSNDVIQD-------------DVFRRLS---------ACHNVLFT 293 V ++ER + F + D++Q D R L + NV+FT Sbjct: 288 VLQDERVMRQSFSNIIAADIVQHLRSDATAYDARDADRVRELQELMLGDALLSKSNVVFT 347 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKG 321 H AF + EA+ + Q T++N++ G Sbjct: 348 PHVAFNSVEAVERVQQVTVENITAFVAG 375 >UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YAK7_DICT6 Length = 316 Score = 149 bits (375), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 89/263 (33%), Positives = 146/263 (55%), Gaps = 19/263 (7%) Query: 56 GSRPVLEELKKHG--VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 G PV ++ K+ +K I+ G +N+D+ AK+ + V P + AVAE +G++ Sbjct: 56 GIDPVTSKVLKNANKLKVISKYGVGVDNIDILEAKKRNIVVTNTPGANSNAVAELTVGLI 115 Query: 114 MTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + + R+I+ + ++TR+ + + G + KT GVIGTG IG ++ +LKGF +R+L F Sbjct: 116 INVLRKINLSDKKTREGRW--DRFIGNELSEKTLGVIGTGSIGRRVIELLKGFNLRVLCF 173 Query: 174 DPYPS-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 D YP A + V YV L L SDV+S+H PLT E YH+++E MK +++NT Sbjct: 174 DKYPDYEWASKEKVFYVTLDELLRSSDVVSIHVPLTEETYHMISEKELRMMKKNAVLINT 233 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 SRG ++D A LK +I G+DV+E E +++ ++Q D NV+ Sbjct: 234 SRGGIVDEDALYRFLKEGRISGAGLDVFEKE-----PPQNSPLLQLD---------NVVV 279 Query: 293 TGHQAFLTAEALTSISQTTLQNL 315 T H T EA+ ++++ ++NL Sbjct: 280 TSHIGAHTEEAVANMAKLAVENL 302 >UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases n=2 Tax=Desulfovibrionaceae RepID=Q1MPI0_LAWIP Length = 323 Score = 149 bits (375), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 97/307 (31%), Positives = 156/307 (50%), Gaps = 22/307 (7%) Query: 21 ESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFN 80 E+ G +L +D E+T + A + + + D + +EEL K +K I + G+N Sbjct: 22 EALG-KLTVYDLTKPEQTVERAKDAD-ILLVGRDILTTEHIEELPK--LKCIGVLGTGYN 77 Query: 81 NVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGF 140 +D++ A + G+ V+ V AY +AVA+HA +++ L R Q R+ +S + Sbjct: 78 QIDIETAGKRGIPVINVTAYGVDAVAQHAFALLLELCRHTAALDQAIRNGAWSSPDWAPW 137 Query: 141 T-----MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLF 195 + K G+IG G IG I GF M +LA+D P + DL +F Sbjct: 138 KYPQVELTYKCFGIIGYGNIGQKAGYIAHGFDMSVLAYDERPVQPPSYTPFSFADLDEVF 197 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 +DV+SLHCPLT +N+HL+N+ E MK+G +I+N +RGAL+D QA +AL + K+G L Sbjct: 198 KNADVLSLHCPLTEDNFHLVNKKRIETMKDGAIIINVARGALLDEQAVADALISGKLGGL 257 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 G D + +E ++ L + N +FT H A+ + EA +I + +NL Sbjct: 258 GSDAFVDE-------------PINLNNPLLSAPNTVFTPHIAWESVEARRNIVRILAENL 304 Query: 316 SNLEKGE 322 G+ Sbjct: 305 KAWMDGK 311 >UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyanobacteria RepID=SERA_SYNY3 Length = 554 Score = 148 bits (374), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 91/252 (36%), Positives = 134/252 (53%), Gaps = 17/252 (6%) Query: 60 VLEELKKHG--VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V E++ + G +K I G +N+D+ AA G+ VV P + A AEHA+ MMM L Sbjct: 81 VTEKIIQAGSQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALA 140 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R I A + +++ + + G +Y KT GV+G GKIG + + K GM+LLA+DP+ Sbjct: 141 RHIPDANKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFI 200 Query: 178 SAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 S A ++G VDL LFSE+D I+LH P TPE +L+N +MK I+N SRG Sbjct: 201 SQERADQIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGG 260 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID +A + A++ +IG +DV+ E E RL NV+ T H Sbjct: 261 IIDEEALVTAIETAQIGGAALDVFAQEP--LGES------------RLREFSNVILTPHL 306 Query: 297 AFLTAEALTSIS 308 T EA +++ Sbjct: 307 GASTEEAQVNVA 318 >UniRef50_B7JZK0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Cyanobacteria RepID=B7JZK0_CYAP8 Length = 319 Score = 148 bits (374), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 96/265 (36%), Positives = 139/265 (52%), Gaps = 17/265 (6%) Query: 53 NDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGM 112 +D + VLE +K +K +A G + +DL+AAK LG+ P + VA+ A+G Sbjct: 58 DDPFTAKVLEIGQKGQLKVLAKWGIGVDAIDLEAAKNLGIYTSNTPNVFGDEVADVALGY 117 Query: 113 MMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 + L R++H+ R N+ + G ++ K AG+IG G IG A+ R K GM LL Sbjct: 118 TLLLARQLHKIDSAIRQGNWL--KIQGTSLRNKVAGIIGVGSIGAAIARRFKVMGMNLLG 175 Query: 173 FDPYPSAAAL--ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 +D L E ++ V+L LF SD I L C LTPENYHLL+E AF QMKNG IV Sbjct: 176 YDVRTIDPKLCQETQLKQVELHQLFQASDCIVLACNLTPENYHLLDEKAFNQMKNGTWIV 235 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RG +ID +A I AL + +I +DV+E+E + E+ L V Sbjct: 236 NVARGPIIDEKALINALDSGRIAGAALDVFESE-PITTENP------------LVKYEQV 282 Query: 291 LFTGHQAFLTAEALTSISQTTLQNL 315 + H + T EA+ ++Q + NL Sbjct: 283 IMGSHNSSNTREAVLRVNQIAIDNL 307 >UniRef50_C7TLC2 D-2-hydroxyacid dehydrogenase n=7 Tax=Lactobacillus RepID=C7TLC2_LACRL Length = 330 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 101/330 (30%), Positives = 167/330 (50%), Gaps = 6/330 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP-- 59 K+ +YS + ++ + + +++ T A G + V I G+ P Sbjct: 3 KILMYSVRPDEQPAIDDWVAANDIQVDTNTVAFNADTVDLAKGYDGVVI--QQHGAIPEP 60 Query: 60 -VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V ++LK G+K + LR G++ V+LDAA GL V VPAY P +VAE + M L R Sbjct: 61 LVYQKLKSFGMKQLTLRITGYDIVNLDAAAANGLAVTNVPAYSPRSVAELVLAHAMRLIR 120 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + A R ++S GL ++ T G+IG GKIG + RI + G ++ DP + Sbjct: 121 HLGEATAREAKDDYSWGGLEAQEVHQLTIGIIGAGKIGSTVARIFRALGSTVIVADPV-T 179 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 L V YVDL TL + +D++++H PL H+L+ AAF++MK ++N +RG ++ Sbjct: 180 RPELADTVRYVDLDTLLATADIVTVHTPLDDITTHMLDAAAFKKMKKTAYLINAARGPIV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D+ A IEAL+ +I +D E E +F D+S + + L A NV + H F Sbjct: 240 DTAALIEALQRGEIAGAALDTIEGEAGIFGVDRSQSGVDNTNLETLKALPNVEISPHIGF 299 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ ++ +L ++ + G P+++ Sbjct: 300 YTDAAVKNMIDISLDDVKTILAGGHSPHQV 329 >UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Thermomicrobia (class) RepID=B9L167_THERP Length = 745 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 98/319 (30%), Positives = 155/319 (48%), Gaps = 27/319 (8%) Query: 17 QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG--VKYIAL 74 Q+ E E + + +K A EA + V + V EL H ++ +A Sbjct: 212 QRARERLASEADVIEVDGRDKPALYEALREADALIVRSETQ--VTRELLAHAPRLRVVAR 269 Query: 75 RCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSL 134 G +N+DL AA E G+ V+ P + + EH + +M+ + R + A T + Sbjct: 270 AGTGVDNIDLQAATEAGILVLNAPGANAVSAGEHTVALMLAIARNLIDANATTHAGRWER 329 Query: 135 EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL-ELGVEYVDLPT 193 + F + GKT G++G G++G + + L+ F RLL +DPY + +LGVE VD T Sbjct: 330 KRFRPFDLKGKTIGIVGLGRVGSVVAQRLRAFECRLLGYDPYITRERFAQLGVEPVDYET 389 Query: 194 LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIG 253 L SD+++ H P TPE H+L+ A +MK G +++N +RG ++D QA EALK+ + Sbjct: 390 LLENSDIVTFHVPATPETRHMLDARAIARMKPGAIVINCARGEVVDVQALAEALKSGHLA 449 Query: 254 SLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTS----ISQ 309 + G+DV+ E Q +F NV+ T H + EAL + I+ Sbjct: 450 AAGVDVFPEE----------PAYQSPLF----GLPNVVLTPHIGGSSREALEAVGEIIAT 495 Query: 310 TTLQNLSNLEKGETCPNEL 328 TTL L +GE PN + Sbjct: 496 TTLAAL----RGEIVPNAV 510 >UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EL38_9FIRM Length = 311 Score = 147 bits (371), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 101/311 (32%), Positives = 161/311 (51%), Gaps = 20/311 (6%) Query: 11 YDKKY--LQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG 68 ++ KY ++ ++ GF++ L + + GC+A I D ++ +E LK Sbjct: 5 FEAKYDAFEERLKAAGFQVVRTGERLPAQIIECGKGCQAAVINAEDQWTKETMEGLKDT- 63 Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 + IA G +NVDLDAA+ LG+KV + E+VAE A+ +M+ RRI + R Sbjct: 64 LGLIARFGVGLDNVDLDAARGLGIKVANSAGANKESVAECAVTLMLECTRRISWLDGKLR 123 Query: 129 DANFSLEGLTGFTMY-GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALELGV 186 D + +GL + GKT G+IG G I + + KGFG ++LA D + AA L Sbjct: 124 DGQW--KGLPRTHQFSGKTVGLIGFGAIAQCVAGMAKGFGCKVLACDVIKNETAAKRLDT 181 Query: 187 EYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 + ++ L +SD ISLH PLT + H+++EA ++MK +++NTSRG ++D +A A Sbjct: 182 VFCEMDELLEKSDFISLHVPLTEDTRHMVSEAFLKKMKPTAILINTSRGPVVDEKALYRA 241 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTS 306 LK I + G+DV+E E D L HN++ T H A T EA + Sbjct: 242 LKEGWIQAAGLDVFEQ------EPPGGD-------NPLFGLHNIIVTPHAASSTEEAAGN 288 Query: 307 ISQTTLQNLSN 317 I+ ++N+ + Sbjct: 289 IADLCMENICS 299 >UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0W672_UNCMA Length = 319 Score = 146 bits (368), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 88/235 (37%), Positives = 128/235 (54%), Gaps = 14/235 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K +AL G+++VDLDAA G+ V P Y EAVAEH M+++ RRI A R Sbjct: 66 LKLVALTRTGYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISEADFWIR 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 + F G + GKT G+IGTG+IG+ + I + FGM ++A+D + A E + Y Sbjct: 126 EEKFDCTAFEGRELRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAVAE-KLRY 184 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V L L +ESD I++H PLT + L++E +F MK G +I+NT+RG ++D A + AL Sbjct: 185 VGLDRLCAESDFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVDQAALLRALD 244 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +I +DV++ E + D L A N L T H A+ T EA Sbjct: 245 EGRIAGACLDVFDQEP-----------LPPD--SPLLAMSNTLLTPHIAYNTREA 286 >UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A7HDB1_ANADF Length = 528 Score = 146 bits (368), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 85/254 (33%), Positives = 135/254 (53%), Gaps = 14/254 (5%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K +K I G +NVDL AA G+ V+ P VAE A+ M++ L+R + A Sbjct: 62 KAARLKVIGRAGVGVDNVDLAAATRRGVVVMNTPGGSSITVAELALSMILALSRHVAAAT 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALE 183 + + + G + G+T GV+G G IG ++ GMR++AFDP+ SA AA + Sbjct: 122 GSVKAGKWEKKRFQGHELAGRTLGVVGIGNIGSVLVARAVALGMRVVAFDPFISAEAAAK 181 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LG VDL TL+ E+DV+S+H PLT + HL++ A +MK G ++VN +RG ++D +A Sbjct: 182 LGASLVDLDTLWREADVVSIHVPLTDKTRHLVDATALGKMKKGALLVNCARGGIVDERAL 241 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +AL++ ++G G+DV+E E L NV+ T H T EA Sbjct: 242 ADALRSGQLGGAGLDVFEQE-------------PPPADHPLYGLENVILTPHIGASTEEA 288 Query: 304 LTSISQTTLQNLSN 317 ++++ + L++ Sbjct: 289 QSAVAVAVAEQLAD 302 >UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetobacter baumannii RepID=B2I1D3_ACIBC Length = 325 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 77/215 (35%), Positives = 122/215 (56%), Gaps = 14/215 (6%) Query: 50 IFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHA 109 IF +D+ L+ + KHGV GF+ +D AA E + V + ++VAEHA Sbjct: 63 IFASDN-----LKVIAKHGV--------GFDTIDTQAAAERKIPVTIAVGANAQSVAEHA 109 Query: 110 IGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR 169 +M + R++ QR R+ ++ G +YGKT G+IG G IG +++++ M+ Sbjct: 110 FALMFNVARQVTWLDQRIREGHWDKASANGVELYGKTLGLIGLGAIGSILMKLVAPLNMK 169 Query: 170 LLAFDPY-PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVM 228 + +DP+ + L+ + D L SD+ISLHCPLT EN HL + + FE+MK+ + Sbjct: 170 VKVYDPFLQNLPELDYVEQEHDFEKLIETSDIISLHCPLTAENKHLFSHSQFEKMKSSSI 229 Query: 229 IVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 ++NT+RG LID A ++ALKN KI G+D + +E Sbjct: 230 LINTARGELIDQAALVDALKNNKIAGAGLDTFSSE 264 >UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Euryarchaeota RepID=A6UQN3_METVS Length = 523 Score = 145 bits (366), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 86/259 (33%), Positives = 136/259 (52%), Gaps = 15/259 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G +NVDLDAA E G+ VV P +VAE G+M++ R I +A + Sbjct: 64 LKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQATASLK 123 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVE 187 + + G +Y KT G++G G+IG + + + F M ++A+DPY P A ELG++ Sbjct: 124 KGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVASELGIK 183 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + + L +ES+ I+LH PLT + H++ + F+ MKN +I+N +RG LID A +A+ Sbjct: 184 LLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDENALYDAI 243 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K+ + G+DV+E E N +I + + ++ T HQ T EA S Sbjct: 244 NCGKVKAAGLDVFEEE-----PPTKNPLI---------SLNGLIGTPHQGASTEEAQLSA 289 Query: 308 SQTTLQNLSNLEKGETCPN 326 + + KGE+ N Sbjct: 290 GTIVAEQTVKILKGESAEN 308 >UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0P693_9FIRM Length = 322 Score = 145 bits (365), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 95/306 (31%), Positives = 156/306 (50%), Gaps = 22/306 (7%) Query: 28 EFFDFLLT--EKTAKTANGCEA-VCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDL 84 E FD+ ++ A C+A +C F V+ + + K I G +N+DL Sbjct: 29 ELFDYHCATEDEVISAAADCDALICQFAPITAR--VIRAMPR--CKVIVRYAIGVDNIDL 84 Query: 85 DAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGF-TMY 143 AA+E G+ V VP Y + V+ HAI ++M +++ + + S + M Sbjct: 85 KAAEEQGVYVCNVPDYSIDEVSNHAIALLMDCVKKLTFLASQVKAGRSSYTVVKPLHRMQ 144 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTLFSESDVIS 202 G T G++G G+I + + + GFG++++A+DP AA ELGV V L +SD +S Sbjct: 145 GSTLGLMGFGRIPRLVAQKMAGFGLKMIAYDPMLDQQAAQELGVTPVSFEQLLMDSDYLS 204 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 +HCPL H+ N+ AF MK ++VNT+RGA++D QA I+AL + +I G+DV E Sbjct: 205 IHCPLNESTRHIFNQEAFRLMKPTAVLVNTARGAVVDEQALIQALSDGQIAMAGLDVTEQ 264 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 E V D+ +L N + T H A+ + EA+ S+ + + ++ + +GE Sbjct: 265 E----------PVAADNPLLKLD---NAVVTPHAAWYSEEAVASLQRKVAEEVARVLRGE 311 Query: 323 TCPNEL 328 T N + Sbjct: 312 TPQNPV 317 >UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG7H23 RepID=B3T9W6_9ZZZZ Length = 491 Score = 145 bits (365), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 83/241 (34%), Positives = 126/241 (52%), Gaps = 15/241 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ I G +NVDLDAA G+ VV P + A AEH + +M+ + R I +A R Sbjct: 30 LQVIGRAGVGVDNVDLDAATRQGIPVVNAPTGNTVAAAEHTLALMLAMVRHIPQADASVR 89 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVE 187 + G + GK G+IG GK+G + R + MR+LA DP+ P +A LGVE Sbjct: 90 MGEWRRSAFMGVEVRGKILGIIGLGKVGSEVARRTRALQMRILAHDPFVPQESARSLGVE 149 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V L L +E+D I++H PLT LL A F+Q+K+GV I+N +RG L++ Q +EAL Sbjct: 150 MVSLDQLMAEADFITIHTPLTATTQQLLGPAQFQQLKHGVRIINAARGGLVNEQLLLEAL 209 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 ++ ++ +DV+ E K + ++Q V+ T H T EA T + Sbjct: 210 ESGRVAGAALDVFVEE-----PPKQSPLLQHP---------RVVLTPHLGASTEEAQTEV 255 Query: 308 S 308 + Sbjct: 256 A 256 >UniRef50_A5ZAJ9 Putative uncharacterized protein n=1 Tax=Eubacterium ventriosum ATCC 27560 RepID=A5ZAJ9_9FIRM Length = 336 Score = 144 bits (364), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 93/260 (35%), Positives = 141/260 (54%), Gaps = 20/260 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR-----A 123 +K I++ G+N VD DAA+E G V + Y + VA+H+I +M+ + R++ Sbjct: 73 LKGISIEATGYNFVDADAAQEQGTAVAVIGEYCTQEVADHSIALMLAVARKLKHYDREIE 132 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE 183 Y+ D N S G+ + G T G++G GKIG A+ R +GFGM ++A+ P E Sbjct: 133 YKHVYDYN-STSGM--IRLEGSTFGILGLGKIGKAVARRAQGFGMNVIAYSPSCKPEVAE 189 Query: 184 -LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 LGV+ V LF SDVIS+H LTPEN ++LN AF MK +IVN SRG++ID +A Sbjct: 190 SLGVKLVSKEELFETSDVISVHMRLTPENENMLNREAFAMMKKKPIIVNVSRGSMIDEEA 249 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +EAL N ++ G+DV E+ + + ++ R +V+ T H AF + Sbjct: 250 LLEALDNGQVFGAGLDV-------LVEETNENTLKCPFVGR----EDVVLTPHTAFYSDF 298 Query: 303 ALTSISQTTLQNLSNLEKGE 322 AL + +NL + +GE Sbjct: 299 ALYECQRIGAENLCYILRGE 318 >UniRef50_Q0C254 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=2 Tax=Hyphomonadaceae RepID=Q0C254_HYPNA Length = 337 Score = 144 bits (364), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 86/250 (34%), Positives = 136/250 (54%), Gaps = 14/250 (5%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V E L V I+ R G+ VD++AA++LG V + +VA+ IGMM+++ Sbjct: 67 TRAVFEALPDLAV--ISRRGVGYEKVDVEAARDLGRVVAIAAGGNDASVADQVIGMMISI 124 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 RR A + +++ L G +Y + G++G G+IG ++ R L GF +L P Sbjct: 125 GRRFQEAQSAMKAGKWNI--LVGTELYRRKVGIVGFGRIGRSLARRLSGFEAEILVCAPR 182 Query: 177 PSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 ++ +E G+ +V TL E+D IS+H PLTPE H+ N AAF +MK +++N++RG Sbjct: 183 LASEDIETFGLRHVAFETLLKEADYISVHAPLTPETRHMFNAAAFGRMKPSAVLINSARG 242 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D A + AL++ +I G+DVYE+E D S + D + R H+V+ H Sbjct: 243 GLVDDTALLAALESGQILGAGLDVYESE-----SDPSKQPVTDALIAR----HDVIAAPH 293 Query: 296 QAFLTAEALT 305 T EAL Sbjct: 294 AGASTHEALA 303 >UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41AB7 Length = 524 Score = 144 bits (363), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 86/241 (35%), Positives = 130/241 (53%), Gaps = 16/241 (6%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K +K IA G +NVD++AA + G+ VV P VAEH +G++++ R+I A Sbjct: 59 KADNLKIIARAGVGVDNVDVNAATKKGIMVVNAPESTSITVAEHTMGLILSTIRKIAIAD 118 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALE 183 + T+ + + G + KT GVIG G+IG ++ K F M +A+DPY P A Sbjct: 119 KSTKAGKWEKKAFMGMELRNKTLGVIGMGRIGSQVVNRCKAFEMDAIAYDPYLPPEVAKN 178 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 +GVE Y D+ + + +D+I++H PLTPE H ++ F+ MK+ +I N +RG +ID A Sbjct: 179 MGVELYEDIEDVLTRADIITIHVPLTPETEHSISTEQFKMMKDTALIFNCARGGVIDEDA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 EAL N +I G+DVYE E +N+ +L N++ T H A T E Sbjct: 239 LYEALVNGEILGAGLDVYEK------EPATNN--------KLFELDNIVCTPHIAASTKE 284 Query: 303 A 303 A Sbjct: 285 A 285 >UniRef50_A7IJ69 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Alphaproteobacteria RepID=A7IJ69_XANP2 Length = 359 Score = 144 bits (363), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 92/259 (35%), Positives = 135/259 (52%), Gaps = 17/259 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA R G++ VD+DAA++LG V + AVA+H I +M+ + RR+ + Sbjct: 105 LKVIARRGVGYDRVDVDAARDLGRVVTIAAGANDPAVADHTIALMLAVLRRLKASQAAIA 164 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD--PYPSAAALELGV 186 ++ + L G + GKT G+IG G+IG + R L GF + +L P P AA GV Sbjct: 165 RGDWRV--LVGADLTGKTVGLIGFGRIGRQVARRLSGFDVTVLVTSRTPDPEAA----GV 218 Query: 187 EYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 +V L L + SDV+SLH PL PE H++N A + MK ++VNTSRG LID + A Sbjct: 219 TFVALDELIARSDVVSLHAPLVPETRHVINAATLKAMKRSAVVVNTSRGGLIDDATLLAA 278 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTS 306 L+ +I G+DV+E E D + L+A NV+ T H A + EAL Sbjct: 279 LEAGEIAGAGLDVFEAEADEALHPLAE---------ALAARENVVATAHAAGSSEEALAR 329 Query: 307 ISQTTLQNLSNLEKGETCP 325 + + Q ++ G P Sbjct: 330 GNLISAQCVAAALAGAPFP 348 >UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MG73_RHOM4 Length = 322 Score = 144 bits (362), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 92/296 (31%), Positives = 149/296 (50%), Gaps = 22/296 (7%) Query: 40 KTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA 99 + A +A+ +D + VLE K ++ +A G+ N+DL+AA+ G+ V P Sbjct: 43 EAAREADALITMPSDPVTARVLENCPK--LRIVAQHAVGYENIDLEAARARGIVVTHTPG 100 Query: 100 YDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS---LEGLTGFTMYGKTAGVIGTGKIG 156 +A A+ +++ L RR+ A + R+ +F + L G + K G++G G+IG Sbjct: 101 VLTDATADFTFALLLALVRRVREADRYVREGHFKRWETKLLLGHDLRDKVLGIVGLGRIG 160 Query: 157 VAMLRILKGFGMRLLAFDPYPSAAALELG--VEYVDLPTLFSESDVISLHCPLTPENYHL 214 A+ R GFGMR++ ++ P+ +E YV L SDVIS+HCPL E+YHL Sbjct: 161 SAVARRALGFGMRVVYYNRRPANPTIERQSCARYVSFDELLRTSDVISIHCPLNKESYHL 220 Query: 215 LNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSND 274 + AAF +MK ++VNT+RG ++D +A +EAL+ +I +DV+E+E Sbjct: 221 FDRAAFAKMKPTAVLVNTARGPIVDEEALVEALEQGQIAGAALDVFEHE----------- 269 Query: 275 VIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN-LSNLEKGETCPNELV 329 V L V+ H T EA T++++ + L+ L E P LV Sbjct: 270 ---PRVHPALLRSDRVVLAPHLGSATVEARTAMARACAEAVLAVLNGEEKIPYRLV 322 >UniRef50_C8ZXV6 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Enterococcus gallinarum EG2 RepID=C8ZXV6_ENTGA Length = 331 Score = 143 bits (361), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 110/328 (33%), Positives = 165/328 (50%), Gaps = 35/328 (10%) Query: 2 KLAVYSTKQYDK---KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAV----CIFVND 54 K+AV ++K + K +++Q++ S DF L E T K A EA+ CI + Sbjct: 5 KIAVVNSKSFGKFFPEHIQRLQASGEV-----DFHLFEPTIKGAQLAEALRDYQCIIAS- 58 Query: 55 DGSRPVLEELKKHGVKYIALRCA---GFNNVDLDAAKELGLKVVRV-PAYDPEAVAEHAI 110 P + + L C G +NVDL AA E + V +V + +AVAEHAI Sbjct: 59 --VTPTFDRTFFQNTPKLGLLCRHGLGVDNVDLSAATENQVLVTKVLGPIERQAVAEHAI 116 Query: 111 GMMMTLNRRIHRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGM 168 ++M R+I++ + ++ + L F + T GVIG G IG + +IL +GFG Sbjct: 117 ALLMNELRKINKGQRLIKNDEWHLRSSCNSFELKHATVGVIGYGNIGSKVGQILHEGFGA 176 Query: 169 RLLAFDPYPSAAALELGV-EYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGV 227 +L +DPY SA + + V LP L SE+DVI+LHC L+ EN +L++AAF+QMK V Sbjct: 177 EVLVYDPYKSAEDIHKAKGKKVSLPELLSEADVITLHCNLSDENQRMLSDAAFDQMKQHV 236 Query: 228 MIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC 287 +++NT+RG L+D A I AL ++I DV+ E D L A Sbjct: 237 LLINTARGELVDEAALIRALARKEISGYAADVFCQE-------------PLDPTHPLLAF 283 Query: 288 HNVLFTGHQAFLTAEALTSISQTTLQNL 315 NV T H T+E+L + + N+ Sbjct: 284 ENVTLTPHIGAYTSESLAGMGDHVVTNI 311 >UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehydrogenases n=3 Tax=Firmicutes RepID=A5D6D4_PELTS Length = 526 Score = 143 bits (361), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 90/263 (34%), Positives = 135/263 (51%), Gaps = 23/263 (8%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K + G +N+D+ AA G+ VV P + AVAEH I MM++L R I +A R Sbjct: 65 LKVVGRAGVGVDNIDVPAATARGILVVNAPEGNTLAVAEHTIAMMLSLARNIPQANASLR 124 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAAALELGV 186 + + G + GK GVIG G+IG A+ + +G M+++A+DPY A L LGV Sbjct: 125 AGKWDKKSFMGVELRGKVLGVIGLGRIGSAVAKRAQGMEMKVVAYDPYINEEKAGL-LGV 183 Query: 187 EYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 + L L ++D I++H PLT E+ ++L E AF MK+GV I+N +RG ++D QA A Sbjct: 184 TLLSLEELLKQADFITVHLPLTRESKYMLGEKAFSLMKDGVRIINCARGGVVDEQALYNA 243 Query: 247 LKNQKIGSLGMDVYENERDL---FFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +K+ K+ +DV+E E + FE K N + T H T EA Sbjct: 244 MKSGKVAGAALDVFEKEPNTDSPLFEFK-----------------NFIATPHLGASTQEA 286 Query: 304 LTSISQTTLQNLSNLEKGETCPN 326 S++ + + KGE N Sbjct: 287 QLSVATDVAREVVAALKGELVKN 309 >UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thermoanaerobacter italicus Ab9 RepID=C6PIV3_9THEO Length = 325 Score = 143 bits (360), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 91/300 (30%), Positives = 152/300 (50%), Gaps = 18/300 (6%) Query: 17 QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 +++ E G E+ + E EA+ + ++ ++E K +K I+ Sbjct: 15 RKILEEKGIEIITAPDVKEETLISMVRDVEAIIVRSKAKITKGIIENAPK--LKIISRTG 72 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG 136 AG +N+D++AA E G+ V +PA + +VAEH I M++ L +++ Q R+ N+ + Sbjct: 73 AGVDNIDVNAATEKGILVCNLPAVNSLSVAEHTIAMILHLAKQLSLMDQAVRNGNWEMRN 132 Query: 137 LT-GFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAAALELGVEYVD-LPT 193 + GKT G++G G IG+ + + G GM+++A+DPY + +VD L Sbjct: 133 SNISVEVEGKTLGIVGMGNIGILVAKKCHDGLGMKIVAYDPYVKEKFKDYDYRFVDSLEE 192 Query: 194 LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIG 253 LF ESD ++LHCP PE ++ MK ++N +RG +ID QA IEALK ++I Sbjct: 193 LFKESDFVTLHCPDIPETRGMITRELIYSMKPTAYLINVARGTVIDEQALIEALKEKRIA 252 Query: 254 SLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQ 313 G+DV++ E +D+ RL NV+ + H A LT EA ++ +Q Sbjct: 253 GAGLDVFQQEPPS----------RDNELLRL---ENVILSPHSAALTKEATVRMAVEAVQ 299 >UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Bacillales RepID=Q49YF7_STAS1 Length = 538 Score = 143 bits (360), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 71/196 (36%), Positives = 119/196 (60%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G +N+D+DAA + G+ V+ P + + EH++ M++++ R I +A+Q + Sbjct: 66 LKVIARAGVGVDNIDVDAATKHGVIVINAPDGNTISATEHSMAMILSMARNIPQAHQSLK 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVE 187 D + + G +Y KT GVIG G+IG+ + + + FGM +LAFDPY S A EL V Sbjct: 126 DGKWDRKTYRGTELYNKTLGVIGAGRIGLGVAKRAQSFGMHILAFDPYLSEDKAKELNVT 185 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + + +SD +++H PLTP+ ++ +A FE+ K + I+N +RG +ID A ++AL Sbjct: 186 RATVEEIAEQSDFVTVHTPLTPKTKGIVGKAFFEKAKPNLQIINVARGGIIDEAALVDAL 245 Query: 248 KNQKIGSLGMDVYENE 263 +I S +DV+E+E Sbjct: 246 NQNQIQSAAIDVFESE 261 >UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Pseudomonas RepID=A5W066_PSEP1 Length = 324 Score = 142 bits (358), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 83/261 (31%), Positives = 147/261 (56%), Gaps = 21/261 (8%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ +A AG++NVD AA + G+ V P + +V EH ++++L R++ A ++TR Sbjct: 63 LRIVARHGAGYDNVDYKAAADHGVWVTNTPGANQRSVIEHVFALLLSLCRKLPLASEQTR 122 Query: 129 DANFSLE--GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAAALEL 184 + ++ + LTG + G+T G++G G IG ++ + + FGM+++ DP PS+ + Sbjct: 123 NRVWAEDRLSLTGIELEGRTLGLVGFGNIGSSVAPVAEAFGMKVIFTDPAIDPSSDS--- 179 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 +VD TL S +DV+SLH PL +L+ F +MK+G M++NTSRG ++D QA + Sbjct: 180 --RWVDFDTLLSTADVVSLHVPLLETTRNLIGVPEFAKMKDGAMLINTSRGGVVDEQALV 237 Query: 245 EALKNQKIGSLGMDVYENER-DLF--FEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 +ALK+ K+ G DV E D+ F+ + D+ + N++ T H A T Sbjct: 238 DALKSGKLAGAGADVLAAENIDMIKPFDHDTPDI---------ANTPNLIVTAHVAGQTD 288 Query: 302 EALTSISQTTLQNLSNLEKGE 322 E+L + + L+ ++ + KG+ Sbjct: 289 ESLLRVGMSALEAIAAVLKGQ 309 >UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms RepID=GYAR_THEPD Length = 339 Score = 142 bits (357), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 86/263 (32%), Positives = 139/263 (52%), Gaps = 19/263 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I+ GF+++D+ A + G+ V P +AVAE +G+++ + RRI A + R Sbjct: 70 LKVISTYSVGFDHIDIPEATKRGIYVTHTPGVLTDAVAEFTVGLILAVTRRIVEADKIIR 129 Query: 129 ----DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD--PYPSAAAL 182 D ++ LTG + GKT G++G G+IGVA + L F +++L +D + Sbjct: 130 TGQWDKPWNPYFLTGPELKGKTIGLVGLGRIGVATAKRLSSFDVKILYYDIERRWDVETV 189 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 +E+ DL TL +SD++S+H PLT E YHL+NE +MK ++NT+RG ++D++A Sbjct: 190 IPNMEFTDLDTLLEKSDIVSIHVPLTKETYHLINEERLRKMKKTAYLINTARGPVVDTEA 249 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 ++ALK I +DV+E E N L+ NV+ H A T E Sbjct: 250 LVKALKEGWIAGAALDVFEQE-----PLPPN--------HPLTKFDNVVLAPHIASATIE 296 Query: 303 ALTSISQTTLQNLSNLEKGETCP 325 A +++ +NL + KGE P Sbjct: 297 ARQRMAELAARNLIAVLKGEMPP 319 >UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verrucomicrobia RepID=B4D991_9BACT Length = 530 Score = 142 bits (357), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 86/237 (36%), Positives = 128/237 (54%), Gaps = 15/237 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +NVD+DAA + G+ V+ P + + AEHA +M++ R I +A + Sbjct: 68 LKVIGRAGVGVDNVDVDAATKRGIIVMNTPGGNTISTAEHAFSLMVSTARNIPQADASVK 127 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + + G +Y KT ++G G+IG + R FGMR+LA+DPY SA+ A L VE Sbjct: 128 SGKWDRKTFVGVELYNKTLAILGMGRIGTEIARRAIAFGMRVLAYDPYLSASRARSLQVE 187 Query: 188 YVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 V+ L + ++D I+LH PLT E ++LN + K GV IVN +RG LID A +EA Sbjct: 188 LVESLDLIIPQADFITLHMPLTAETKYMLNAERLAKTKKGVRIVNCARGGLIDEAALVEA 247 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 LK++++ + +DV+E E L E L N++ T H TAEA Sbjct: 248 LKSKQVAAAALDVFEAE-PLPAESP------------LRGLPNLILTPHLGASTAEA 291 >UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verrucomicrobiales RepID=B5JEX5_9BACT Length = 545 Score = 141 bits (356), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 95/313 (30%), Positives = 160/313 (51%), Gaps = 22/313 (7%) Query: 18 QVNESFG-FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 +V E++G F+ ++ FL + A G A+ + + +R V E + +K + Sbjct: 37 EVVEAYGTFKEDYSKFL------ELAKGAAAIIVRSDSKVTREVFE-VAAPTLKAVGRAG 89 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG 136 G +N+D +AA + G+ V+ P + A AE M+ R + +A Q R+ + + Sbjct: 90 VGVDNIDSEAATDFGVVVMNTPGGNTIATAELTFTHMLCGARPVPQAAQSMREGRWDRKI 149 Query: 137 LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVEYVDLPTLF 195 G ++ KT GV G G+IG + + K FGM++LA+DPY S A E +GVE V+L LF Sbjct: 150 YGGSELFKKTLGVCGMGRIGAEVAKRAKAFGMKVLAYDPYLSGAKAETMGVEQVELDELF 209 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 ESD I++H PLT ++++AA MK+GV + N +RG +ID A + L++ K+ + Sbjct: 210 RESDYITVHMPLTDATRGMIDDAAIATMKDGVRLFNCARGGIIDEDALLRGLESGKVAAA 269 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 G+DVY +E +D FR + T H T EA S+ +++ Sbjct: 270 GLDVYTSEPPA----------EDHPFRSQKTLN---LTPHLGASTEEAQESVGLEIAESV 316 Query: 316 SNLEKGETCPNEL 328 +++ +G N + Sbjct: 317 TSVLRGGGIRNAI 329 >UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacteria RepID=Q5WLJ2_BACSK Length = 316 Score = 141 bits (355), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 81/228 (35%), Positives = 124/228 (54%), Gaps = 16/228 (7%) Query: 42 ANGCEAVCIFVNDD-----GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVR 96 A G +A + N+ P L+ + KHGV G +N+D+DAAK+ G+ V Sbjct: 44 ARGAQAAIVAFNEIHDAVLAQLPDLKIIAKHGV--------GVDNIDVDAAKKHGVTVTN 95 Query: 97 VPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIG 156 VP + AVA+ A ++++L R+I ++T+ + L G +Y +T G+IG G IG Sbjct: 96 VPNANKHAVADFAFSLLLSLARQIPTGNEKTKKGKWP--SLFGADVYQQTLGIIGLGAIG 153 Query: 157 VAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLL 215 + R GF M +LA+DPY A + G+E V L L +SD +++H PL PE HL+ Sbjct: 154 KEVARRASGFSMTVLAYDPYIDRTYARKNGIEAVSLDALLQQSDFVTIHIPLLPETRHLI 213 Query: 216 NEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 E + MK +VN SRG ++D A EAL+ Q++ +DV+E E Sbjct: 214 GERELQLMKKSAYLVNASRGGIVDETALYEALQTQQLAGAALDVFEEE 261 >UniRef50_B1SFW3 Putative uncharacterized protein n=1 Tax=Streptococcus infantarius subsp. infantarius ATCC BAA-102 RepID=B1SFW3_9STRE Length = 321 Score = 141 bits (355), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 85/249 (34%), Positives = 138/249 (55%), Gaps = 16/249 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR--IHRAYQR 126 +K IA+ G N +D D A++LG+ V + AY E VA H I +++ LN++ IHR + Sbjct: 74 LKGIAVNATGTNTIDTDYAEKLGVAVSNLRAYSTEDVANHTIALLLALNQKLFIHRKFIV 133 Query: 127 TRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELG 185 ++ G + +T + G G+IG A+ + K FGM ++A+DP+ P A +LG Sbjct: 134 AGFWSYQKAGEVK-RLSSQTLAIFGLGRIGQAVAKRAKSFGMSVIAYDPFIPEEVADQLG 192 Query: 186 VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 V+ V + T+ +E+DVISLH N H N F+++K V+ +N +RG+L+D A IE Sbjct: 193 VKLVSIETIQAEADVISLHLFANSANEHFFNRDFFKKLKKPVIFINVARGSLVDEVALIE 252 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 AL K+ G+DV E+E N + D+ F + NV+ T H AF + ++L Sbjct: 253 ALDEGKVIGAGLDVLESE---------NPDLSDNPFLKRD---NVILTPHSAFYSQDSLN 300 Query: 306 SISQTTLQN 314 ++ T++N Sbjct: 301 TLQVQTVKN 309 >UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Staphylococcus RepID=Q5HNI1_STAEQ Length = 531 Score = 140 bits (354), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 69/198 (34%), Positives = 119/198 (60%), Gaps = 5/198 (2%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G +N++++AA G+ V+ P + + EH++ M++ + R I +A+Q R Sbjct: 67 LKVIARAGVGVDNINIEAATLKGILVINAPDGNTISATEHSVAMLLAMARNIPQAHQSLR 126 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY---PSAAALELG 185 + ++ + G +YGKT GVIG G+IG+ + + + FGM++LAFDPY A +L++ Sbjct: 127 NKEWNRKAFRGVELYGKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTEDKAKSLDIQ 186 Query: 186 VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 + VD + +SD +++H PLTP+ ++ + F + K + I+N +RG +ID A IE Sbjct: 187 IATVD--EIAEKSDFVTVHTPLTPKTRGIVGSSFFNKAKQNLQIINVARGGIIDETALIE 244 Query: 246 ALKNQKIGSLGMDVYENE 263 AL N I +DV+E+E Sbjct: 245 ALDNNLIDRAAIDVFEHE 262 >UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Firmicutes RepID=Q04AA8_LACDB Length = 316 Score = 140 bits (354), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 138/254 (54%), Gaps = 14/254 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K+I++ G ++VDL+A KE + + Y +AVAE AIG+ + R+I + + Sbjct: 71 LKFISVAFVGIDHVDLEACKEKKINISNTGGYCNDAVAELAIGLTLDCLRKISAGNEAVQ 130 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 A GL G + GKT G++GTG IG I K FG +L+ + AAAL+LG+EY Sbjct: 131 -AGEGKGGLQGHELAGKTVGIVGTGAIGCRTAEIFKAFGCKLIGYSRSQKAAALDLGLEY 189 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 L + E+D++S+H PLTPE L+ + +MK G +++NT+RG ++D++A ALK Sbjct: 190 KSLDEVMGEADIVSIHTPLTPETKGLIGKKEIGEMKEGAILINTARGPVVDTEALAAALK 249 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 +I + G+DV++ + L + L N++ + H F T E++ + Sbjct: 250 EGRIKA-GLDVFDQDPPLPAD------------YPLLGVPNLVCSPHVGFDTKESIDRRA 296 Query: 309 QTTLQNLSNLEKGE 322 + +N++ G+ Sbjct: 297 EMAFENVTAWLNGQ 310 >UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (class) RepID=B9L1V2_THERP Length = 333 Score = 140 bits (353), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 97/296 (32%), Positives = 145/296 (48%), Gaps = 24/296 (8%) Query: 34 LTEKTAKTANGCEAVCIFVNDD-----GSRPVLEELKKHG--VKYIALRCAGFNNVDLDA 86 EK + E +C V D G P+ + H +K I+ GF+N+D+ Sbjct: 39 FVEKEIRYPVDEEQLCELVRDVDGLVVGLEPITARVLAHANRLKVISTSGVGFDNIDVAE 98 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKT 146 A G+ V + +VAE A G+M+ L R IHR+ + R+ + E G ++GKT Sbjct: 99 ATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMREGRW--EPYFGVELWGKT 156 Query: 147 AGVIGTGKIGVAMLRILKGFGMRLLAFD-PYPSAAALELGVEYVDLPTLFSESDVISLHC 205 GVIG G+ G A+ + +GFGMR+LA D + + A + YV L L ESD +SLH Sbjct: 157 LGVIGLGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISYVPLEKLLRESDFVSLHV 216 Query: 206 PLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERD 265 PLTP+ +L++E A MK ++N +RG ++ A +EAL+ +I G+DV+E E Sbjct: 217 PLTPDTRYLIDERALSLMKPTAFLINLARGPVVKQSALVEALRRGQIAGAGLDVFEVE-- 274 Query: 266 LFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 I+D+ F NV+ T H T EA L N+ N+ G Sbjct: 275 ---------PIRDNPFVEFE---NVVMTPHLGGSTEEARERTLYLALTNVCNVLNG 318 >UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JIG3_9ARCH Length = 542 Score = 140 bits (352), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 69/196 (35%), Positives = 115/196 (58%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +N+D++ A E G+ VV P + + AEH M+++++R+I A + Sbjct: 73 LKVIGRAGVGVDNIDVERATEKGILVVNSPEANSISAAEHTFAMLLSISRKIPAANVSLK 132 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + + G + GK G IG G++G + + KGFGMR++A DP+ SAA A ELG+ Sbjct: 133 SGKWERKKHMGVEVNGKVLGTIGLGRVGSEVAKRAKGFGMRVVAHDPFISAAKAKELGIT 192 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + + + +D I+LH PLT + +H++ + FE MK+GV ++N +RG ++D A EA+ Sbjct: 193 LLGFKEVLATADFITLHTPLTKDTHHMIGKGEFELMKDGVRVINCARGGILDEDALKEAI 252 Query: 248 KNQKIGSLGMDVYENE 263 K K+ +DV+E E Sbjct: 253 KAGKVAGAALDVFEQE 268 >UniRef50_Q03UK9 Lactate dehydrogenase n=5 Tax=Leuconostocaceae RepID=Q03UK9_LEUMM Length = 329 Score = 140 bits (352), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 96/332 (28%), Positives = 162/332 (48%), Gaps = 7/332 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ +Y+T + Y+++ E G E+ D L E T A G +A+ + PV Sbjct: 1 MKILMYNTVSDEMPYVEKWTEKTGHEVVTIDQPLNETTVDRAKGFDAITTQQTTAINAPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL---N 117 +L + +K IA+R G++ +DL A +++ V AY P A+AE+ + + L N Sbjct: 61 YAQLAQFNIKQIAIRQVGYDVLDLPEAFAHNIRLSNVAAYSPRAIAEYTLTQLFNLIRHN 120 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 ++ RA T D ++ G ++ T VIG G+IG A+ +L G +L DP Sbjct: 121 KKFDRA-MNTGDYTWAAGG-QAREIHDLTVAVIGVGRIGTALAEMLHALGATVLGVDPIY 178 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A E V Y L S +DVIS H PL E ++ +E F +++ G +++N +RG + Sbjct: 179 RAQN-EPFVTYTTLDDALSRADVISFHTPLNDETRYMADENFFAKIQPGTIMLNFARGEI 237 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D +AL+++ + DV NE D + + + DV +RL N L + H A Sbjct: 238 VDMVELEKALESKLLAGAAFDVTPNENDFMNQKQDITALPADV-KRLIEYDNFLLSPHIA 296 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 F T A+ ++ + L + + G NE++ Sbjct: 297 FYTNTAIKNMVEMALNDAVTMVNGGVTENEIL 328 >UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PHF7_9FIRM Length = 319 Score = 139 bits (351), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 85/239 (35%), Positives = 132/239 (55%), Gaps = 9/239 (3%) Query: 26 ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLD 85 EL ++ F E+ A A + I + D + V + K +K +A G +N+DL+ Sbjct: 35 ELPYYSF---EELAVWAPEIDGAIIGM-DQWNEQVFQIAPK--LKILARFGVGVDNIDLE 88 Query: 86 AAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGK 145 AAK G++VV + AVAE A+ M++ R I ++ D +S G + GK Sbjct: 89 AAKRHGVQVVNAAGMNANAVAELAVAMILNCLRGIPELNRKLTDGQWSRA--VGRDLLGK 146 Query: 146 TAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALELGVEYVDLPTLFSESDVISLH 204 T G++G G IG + + L GF +RLLA+DPYP+ A LGV DL T+ ++SD++S+H Sbjct: 147 TVGLLGFGDIGGRVAKKLSGFEVRLLAYDPYPNREKAAALGVTLTDLDTVLTQSDILSIH 206 Query: 205 CPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 P P H++N F +MK +NT+RGAL+D+QA ++A+ + +DVYE E Sbjct: 207 MPSIPATRHVMNRETFAKMKPDSYFINTARGALVDTQALVDAVAGGHLAGAAVDVYEQE 265 >UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PA81_9FIRM Length = 316 Score = 139 bits (350), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 89/250 (35%), Positives = 140/250 (56%), Gaps = 20/250 (8%) Query: 25 FELEFFDFLLTEKTAKTANGCEAVCIFVND---DGSRPVLEELKKHGVKYIALRCAGFNN 81 F+++++D E+T + EAV FVN D V E +++ G+N Sbjct: 24 FKIKWYDNTPPEQTIERIGTAEAV--FVNRLRLDAR--VFEACPS--LRFAGTFGTGYNM 77 Query: 82 VDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR--RIHRAY----QRTRDANFSLE 135 +DLDAA+ G+ V VPAY AVA++ I +++ + IH Y T + +L Sbjct: 78 IDLDAARRAGVTVCNVPAYSTAAVAQNTISLLLNIATMTHIHSRYVSTGHWTDPTDHALV 137 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF--DPYPSAAALELGVEYVDLPT 193 + F + GKT G+IG G IG A+ RI FGMR+LA+ P PSA A + +V L Sbjct: 138 SVPMFELAGKTIGLIGCGDIGSAVGRIAAAFGMRVLAYRRHPDPSAGAY---IRFVALDA 194 Query: 194 LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIG 253 L+++SD++SLHCPLTP+ +++ AA +MK+G +++NT+RG L+ + +AL K+ Sbjct: 195 LYAQSDIVSLHCPLTPQTRGMIDRAAIGRMKDGAVLLNTARGGLLCERDVADALDCGKLY 254 Query: 254 SLGMDVYENE 263 G+DV +E Sbjct: 255 MAGLDVLCDE 264 >UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTH2_9ACTO Length = 324 Score = 139 bits (350), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 98/318 (30%), Positives = 158/318 (49%), Gaps = 26/318 (8%) Query: 14 KYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVK 70 K+ +++ E G+E+ + L ++ K A C V + DD S PVL +L ++ Sbjct: 21 KFARKLLEESGYEVTYNQSGKPLDADQLVKAARDCVGVLAGL-DDFSTPVLNQLPD--LR 77 Query: 71 YIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDA 130 I+ G + VDL A + G+ V P + AVAE A+ M TL R + + + TR Sbjct: 78 VISRYGVGVDRVDLRTAGDNGVIVTNTPGANSTAVAEMALSSMFTLARHVSQLNETTRRG 137 Query: 131 NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAAALELGVEY 188 + + G + T G++G G IG A+ R++ G M++L +DP+ P + V+ Sbjct: 138 QWLR--VVGTELSQATLGIVGYGSIGRALRRLVTGLEMKVLVYDPFFDPDT---DPTVQG 192 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V+L L ES+ ISLH PLTP HL +++ F M G ++NTSRG +ID AA+ AL+ Sbjct: 193 VELAELVRESNFISLHLPLTPATEHLFDDSMFRLMSPGTFLINTSRGGIIDESAAVVALE 252 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 ++ L +D YE E + ++FR NV+ T H T ++ ++ Sbjct: 253 AGQLAGLALDAYEQE---------PPSPEHELFR----FSNVIATPHSGAQTVQSRIRMA 299 Query: 309 QTTLQNLSNLEKGETCPN 326 + + NL GE+ N Sbjct: 300 RGAVDNLLRALAGESVTN 317 >UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0DAP4_9CLOT Length = 320 Score = 138 bits (347), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 85/269 (31%), Positives = 134/269 (49%), Gaps = 17/269 (6%) Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 D R V+E L+ K I G NN+D AA E G+ V VP Y V++ A+ M++ Sbjct: 54 DIDRQVIESLEH--CKMIIKYGIGVNNIDCRAAGEKGIYVCNVPDYGVHEVSDQAVTMIL 111 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKT-AGVIGTGKIGVAMLRILKGFGMRLLAF 173 L +++ + R + G+ + + AG+IG G+I + R L+ FGM +L + Sbjct: 112 CLGKKLEPLQEDLRRGKWGYGGIVPVKRFTECKAGLIGFGRIPQMVCRKLQAFGMEILVY 171 Query: 174 DPYPSAAALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 DP+ A +E G + + +D IS+HCPLT E H++ E F MK IVNT Sbjct: 172 DPFVDDAVIEAAGAVRASVEEICRNADFISVHCPLTEETRHMIGEKEFAMMKPECCIVNT 231 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG ++D QA I AL +I G+DV+E E V+ L NV+ Sbjct: 232 ARGGVVDEQALIGALNEGRIAGAGVDVFEEE-------------PVSVYHPLLHMENVIA 278 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKG 321 T H A+ + A+T++ + + + N+ +G Sbjct: 279 TPHSAWYSETAITTLQRKAAEEVVNVLQG 307 >UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplastic n=43 Tax=Viridiplantae RepID=SERA_ARATH Length = 624 Score = 138 bits (347), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 87/267 (32%), Positives = 128/267 (47%), Gaps = 15/267 (5%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V E K +K + G +NVDL AA E G VV P + A AEH I ++ ++ Sbjct: 135 TREVFEAAKGR-LKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASM 193 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R + +A + + G ++ GKT V+G GK+G + R KG GM +++ DPY Sbjct: 194 ARNVAQADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPY 253 Query: 177 -PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P+ A LGV+ V S +D +SLH PLTP + N+ F +MK GV ++N +RG Sbjct: 254 APADRARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARG 313 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +ID A + AL + +DV+ E S D RL NV T H Sbjct: 314 GVIDEDALVRALDAGIVAQAALDVFCE------EPPSKD-------SRLIQHENVTVTPH 360 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGE 322 T EA ++ + ++ KGE Sbjct: 361 LGASTKEAQEGVAIEIAEAVAGALKGE 387 >UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31769 Length = 541 Score = 138 bits (347), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 88/256 (34%), Positives = 131/256 (51%), Gaps = 16/256 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ I G NNVD+ AA G+ V P + AEH + ++++L R + +A++ Sbjct: 70 LRVIGRAGVGVNNVDVPAATRRGIVVANAPQSNVVTAAEHTMALLLSLARNVPQAHRSLT 129 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL-ELGVE 187 D + G +Y KT GV+G G+IG + KGFGM+++AFDP+ A +LGVE Sbjct: 130 DHRWERSKFGGVEVYEKTLGVVGFGRIGQLVAERAKGFGMKVVAFDPFVGAERYRDLGVE 189 Query: 188 YVDLPT-LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 D ++ +D I++H P+TPE LN AF QMK+GV IVN +RG L+D A +A Sbjct: 190 KADTSADVYKVADFITIHLPVTPETQGWLNAEAFAQMKDGVRIVNCARGELVDDAALKDA 249 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTS 306 L + K+ +DV+ +E I D + NV+ T H TAEA Sbjct: 250 LDSGKVAGAALDVFPSEP-----------ITD--YPLFDGYANVVVTPHLGASTAEAQDR 296 Query: 307 IS-QTTLQNLSNLEKG 321 QT Q ++ L G Sbjct: 297 AGVQTAEQVIAALTGG 312 >UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=5 Tax=Thermotogaceae RepID=A9BJ57_PETMO Length = 310 Score = 137 bits (346), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 81/249 (32%), Positives = 131/249 (52%), Gaps = 15/249 (6%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 ++ +LE K +K +A G +N+D+D AK G+ V+ P + +VAE IGM++ + Sbjct: 55 TKEILEHADK--LKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDI 112 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R I R ++ + + L GF + KT G+IG G +G + ++LKGF L +D + Sbjct: 113 YRHITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVF 172 Query: 177 PSAAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 +A + V V L L SD+ISLH P + YH ++E + MK+G +I+N +R Sbjct: 173 EISAEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAAR 232 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D ++ LKN K+ +G+DV+E E + D ++ L A NV+ T Sbjct: 233 GGVLDENYVLKYLKNGKLLGVGLDVFEEEPP-----------KGDFYKELFALPNVVLTP 281 Query: 295 HQAFLTAEA 303 H T EA Sbjct: 282 HIGASTKEA 290 >UniRef50_C7RDP2 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Anaerococcus RepID=C7RDP2_ANAPD Length = 315 Score = 137 bits (346), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 102/325 (31%), Positives = 156/325 (48%), Gaps = 34/325 (10%) Query: 1 MKLAVYSTKQYDKKYLQQVNE---SFGFELEFFDFLLTEKTAKTANGCEA-----VCIFV 52 MK+++ + D++ ++ E S G E E+F+ E T E + I Sbjct: 1 MKISLIDPLEVDREIIENHKEKIESLGHEFEYFE----ESTGSDEEKIERLKDTDIAIIT 56 Query: 53 NDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGM 112 N + V+ K + I + G ++VDL+A KE G+KV+ Y ++VAE IG+ Sbjct: 57 NKPLTSQVINNTK---LDLIDVAFTGVDHVDLEACKEKGIKVLNASGYSDDSVAELVIGL 113 Query: 113 MMTLNRRIHRAYQRTRDANFSLEG--LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 ++ + R + R F E L G + GKT GVIGTG IG ++ +L FG ++ Sbjct: 114 TIS----VLRKFNENRGNIFDGENNYLLGELIKGKTFGVIGTGNIGSKLIDLLSVFGCKI 169 Query: 171 LAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 +A+ GVEYVDLPTL ESD++SLH P E L + MK G +++ Sbjct: 170 IAYSRTEKEEIKAKGVEYVDLPTLLKESDIVSLHIPNNKETKGFLGSEELDLMKEGAVLI 229 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RGA++D+ + L K+ + G+DV++ E L ED L NV Sbjct: 230 NCARGAVVDNDYLAKLLNEDKLRA-GIDVFDMEPPL-PEDYP-----------LRNAKNV 276 Query: 291 LFTGHQAFLTAEALTSISQTTLQNL 315 + T H AF T EA+ + NL Sbjct: 277 ILTNHVAFYTKEAMEIRADIVFDNL 301 >UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CX87_HALOH Length = 527 Score = 137 bits (345), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 82/245 (33%), Positives = 127/245 (51%), Gaps = 13/245 (5%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K +K I G++N+D++ A + G+ V P + + EH IGMM+ L+R I +A Sbjct: 60 KARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQAN 119 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALE 183 Q + + + G + GKT G+IG G+IG + + FGM+++A DPY P A + Sbjct: 120 QALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAAK 179 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 + V + + +SD I+LH PLT E YH+L+ F MK+ V I+N +RG +D+QA Sbjct: 180 INVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQAL 239 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +AL K+ +DV+E E ED QD V+ T H T EA Sbjct: 240 AKALAEHKVAGAAIDVHEVEP--LPEDNPLLKYQD----------RVIMTCHLGGTTTEA 287 Query: 304 LTSIS 308 + ++S Sbjct: 288 MDNVS 292 >UniRef50_A8IH65 D-isomer specific 2-hydroxyacid dehydrogenase n=3 Tax=Proteobacteria RepID=A8IH65_AZOC5 Length = 325 Score = 137 bits (344), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 84/256 (32%), Positives = 133/256 (51%), Gaps = 14/256 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA AG N++D++AA LGL V+ + +VAEHA+ +++ L + I R Sbjct: 70 LKLIAKHGAGTNDIDVEAAAALGLPVIAAVGANAHSVAEHALALLLALAKDIRTQDAFVR 129 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 + GF + G+T G++G G IG + +++ GM + +DP+ + A VE Sbjct: 130 GGGWEKRVYKGFELRGRTLGLVGLGMIGRSFAAMVQPLGMTVFGYDPFAAPEAFGPHVER 189 Query: 189 V-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V DL + DVISLHCPLTP+ L+N A MK G +++NT+RG ++D +A + AL Sbjct: 190 VADLDDMLGRCDVISLHCPLTPQTEGLINARALGLMKPGSLLINTARGEVVDEEALVAAL 249 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 KN +G G+D + +E L + NV+ + H +T +A + Sbjct: 250 KNGPLGGAGLDSFAHE-------------PPSPTHPLWSLPNVILSPHIGGVTEDARRQV 296 Query: 308 SQTTLQNLSNLEKGET 323 S T N++ L GET Sbjct: 297 STMTATNVAALMTGET 312 >UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC4ADC Length = 319 Score = 137 bits (344), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 92/288 (31%), Positives = 146/288 (50%), Gaps = 22/288 (7%) Query: 21 ESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG--VKYIALRCAG 78 +S+GFE++ E K C+A+ + + P E + K G +K +A AG Sbjct: 20 KSYGFEIKHGSGASEEDLIKDVADCDAILL-----RTAPCTEAVLKAGKNLKIVARHGAG 74 Query: 79 FNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG-L 137 +NNVDL+AA +LG+ P VAE +G ++ +++RI ++ ++ +F + Sbjct: 75 YNNVDLEAAAKLGIWATNAPDSTTNTVAEFVLGAILAVSKRIFLMNKKIKEGDFFFKNNH 134 Query: 138 TGFTMYGKTAGVIGTGKIGVAM-LRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFS 196 G + GK GV+G G+IG + + G GM +LA+DP+ + V D T+F Sbjct: 135 KGMDLTGKKLGVVGFGRIGRKVAYKAFYGLGMEILAYDPFLTKENCPDYVTICDWETIFK 194 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 ESD+ISLH PL EN + + F MK +N +RG +++ + IEALK ++I Sbjct: 195 ESDIISLHMPLIKENIGCVGKKEFTNMKKSAHFINCARGEVVNEKELIEALKTEEIAGAF 254 Query: 257 MDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 +DV+E E L ED N ++ D NV+ T H A T E + Sbjct: 255 LDVFEQEPPL--ED--NPLLSMD---------NVIVTPHMASNTEECM 289 >UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax=Clostridiales RepID=C4ZHF5_EUBR3 Length = 329 Score = 137 bits (344), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 81/260 (31%), Positives = 137/260 (52%), Gaps = 16/260 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G+++VD+ A ELG+ VV P + +VAEHA+ M+ L++ + A Sbjct: 62 LKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEMC 121 Query: 129 DANFSLEGLT-GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGV 186 N+ + G F + KT G++G G IG +I KG GMR+ A+DP+ + +E G Sbjct: 122 KGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQVEGYGA 181 Query: 187 EYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 +Y D L +SDV+S+H PLT + +++++ MK +I+N SRG +I+ +E Sbjct: 182 KYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLVE 241 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 AL N I G DV+ +E K++D + + C N++ + H A T EA+ Sbjct: 242 ALNNGVIAGAGTDVFCSE-----PPKTDDPLLN--------CRNLIVSPHSAAQTREAVI 288 Query: 306 SISQTTLQNLSNLEKGETCP 325 ++Q ++ + +G+ P Sbjct: 289 KMAQMCIKGCLAVVEGKKWP 308 >UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clostridia RepID=B0TAQ8_HELMI Length = 526 Score = 136 bits (343), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 71/196 (36%), Positives = 112/196 (57%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +N+D++AA G+ VV P + A AE + ++ + R + A + Sbjct: 65 LKAIGRAGVGVDNIDVEAATRKGIVVVNAPEGNTIAAAELTVAHILAIARNVGSANLSLK 124 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVE 187 + TG + GKT G++G GKIG + + + F M ++A+DPY S A LGV Sbjct: 125 GGKWDRSKYTGIELKGKTLGILGLGKIGSEVAKRARAFDMTVIAYDPYASVEKAKSLGVT 184 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 DL T+F +SD I++H P T + Y +++ A F MK GV IVN +RG +ID QA +A+ Sbjct: 185 VTDLETVFRQSDFITVHMPKTKDTYRMISAAQFAIMKEGVRIVNCARGGIIDEQALYDAI 244 Query: 248 KNQKIGSLGMDVYENE 263 ++ K+ + G+DV+E E Sbjct: 245 QSGKVAAAGLDVFEKE 260 >UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staphylococcus RepID=Q4L766_STAHJ Length = 532 Score = 136 bits (342), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 65/200 (32%), Positives = 118/200 (59%), Gaps = 1/200 (0%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K +K IA G +N+D+DAA G+ V+ P + + EH++ M++ + R I +A+ Sbjct: 63 KASNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNTISATEHSVAMILAMARNIPQAH 122 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALE 183 ++ ++ + G +Y KT GVIG G+IG+ + + L+ FGM++LA+DPY + A + Sbjct: 123 ASLKNKEWNRKAFKGVELYQKTLGVIGAGRIGIGVAQRLQSFGMKVLAYDPYLTEDKAQQ 182 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LGV+ + + ++D +++H PLTP+ ++N F + K + I+N +RG +I+ Sbjct: 183 LGVKLATIDEIARQADFVTVHTPLTPKTRGIVNADFFSKAKPTLQIINVARGGIINEDDL 242 Query: 244 IEALKNQKIGSLGMDVYENE 263 + AL N +I +DV+E+E Sbjct: 243 LNALNNNQIARAALDVFEHE 262 >UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acidobacteria RepID=Q1IVI0_ACIBL Length = 531 Score = 136 bits (342), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 73/196 (37%), Positives = 110/196 (56%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ I G +N++L+AA G+ V+ P + AVAEH IG+M+ L R I RA + Sbjct: 66 LRVIGRAGVGVDNIELEAATRKGIAVMNTPGANAIAVAEHTIGLMLALARFIPRATETMH 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + + L G + GKT G++G G+IG+ + R FGM L+A DPY S A A + + Sbjct: 126 AGKWEKKSLQGTELRGKTLGIVGLGRIGLEVARRAASFGMTLVAHDPYVSPAIAHDAKIR 185 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 D + + +D I+LH LTP+ +++N MK GV IVN +RG LID A EA+ Sbjct: 186 LADRDEVLAVADYITLHVGLTPQTANMINATTLATMKKGVRIVNCARGELIDDAALAEAV 245 Query: 248 KNQKIGSLGMDVYENE 263 K+ +G +DV+ E Sbjct: 246 KSGHVGGAALDVFTEE 261 >UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces RepID=UPI0001B4E409 Length = 333 Score = 135 bits (341), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 80/225 (35%), Positives = 118/225 (52%), Gaps = 4/225 (1%) Query: 42 ANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYD 101 A G + ND +L+ +K + L GF+ VD +AA E G+ V P Sbjct: 44 AAGASGILCLGNDRVDAALLDAAGPS-LKVVGLASMGFDGVDREAAAERGVVVTHTPGVL 102 Query: 102 PEAVAEHAIGMMMTLNRRIHRAYQR---TRDANFSLEGLTGFTMYGKTAGVIGTGKIGVA 158 E A+ +++ RR+ A R F ++ G ++G T G++G G+IG A Sbjct: 103 AETTADLTFSLILMARRRLGAARDSLAAGRWDLFRMDDYLGLDIHGATLGLVGFGQIGRA 162 Query: 159 MLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEA 218 + R +GFGMR+L DP+ + + VDLPTL +E+DV+SLH PLTP HL+ A Sbjct: 163 VARRAQGFGMRVLHHDPFAPDDTQDPPSKAVDLPTLLAEADVVSLHVPLTPGTRHLIGAA 222 Query: 219 AFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 MK+ +V+TSRG +ID A + A++ I S G+DVYE E Sbjct: 223 ELAAMKSTATLVSTSRGGVIDENALLHAVREGGIHSAGLDVYERE 267 >UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales RepID=B1R2D5_CLOBU Length = 314 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 100/327 (30%), Positives = 155/327 (47%), Gaps = 22/327 (6%) Query: 1 MKLAVYSTKQYDK-KYLQQVNESFG--FELEFFDFLLTEKTAKTANGCEA-VCIFVNDDG 56 MKL++ +K K+L + G E+ ++D + + +A + + N Sbjct: 1 MKLSILEPLGVEKEKFLNMAEKVLGDRVEITYYDNRVEDSETLIERSKDAEIVVLSNFQY 60 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 + V+E K +K I + G ++VD+D K+ G+ V Y AVA+ G+++ + Sbjct: 61 RKDVIE--KCPNLKMICVAFTGVDHVDIDYCKDRGITVCNCAGYSTVAVADLVFGLLINI 118 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R I TR + GL GF + GK GVIGTG IG+ + I K FG + A Y Sbjct: 119 YRNIVECNIVTRKGG-TKNGLVGFELEGKKFGVIGTGAIGMRVANIAKAFGCEVYA---Y 174 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 ++YVDL TL S DVISLH PL L+NE + MK +++NT+RG Sbjct: 175 SRTVKEGKEIKYVDLNTLLSTCDVISLHVPLNENTKGLINEENIKLMKKSAVLINTARGP 234 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++DS+A +ALKN I G+DV+E E + V L N++ T H Sbjct: 235 VVDSKALSDALKNNIIAGAGIDVFEIEPPI------------PVDHVLFDAPNLIVTPHV 282 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGET 323 AF T E++ ++ N+ G + Sbjct: 283 AFATKESMVKRAEIVFDNIDKYINGSS 309 >UniRef50_A5F5E1 2-hydroxyacid dehydrogenase family protein n=44 Tax=Proteobacteria RepID=A5F5E1_VIBC3 Length = 325 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 90/274 (32%), Positives = 139/274 (50%), Gaps = 25/274 (9%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R +L +L K +K IA+ G NNVDL A +L + V V Y +V EH I MM L Sbjct: 63 TREMLVQLPK--LKLIAISATGTNNVDLQACSDLNIAVCNVQGYATRSVPEHVIAMMFAL 120 Query: 117 NRRI---HR-----AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGM 168 R + H +QR + F + G T G+IG+G +G A + + GM Sbjct: 121 RRNLIGYHNDIAAGEWQRHKQFCFFTHPIGDIA--GSTMGIIGSGALGQATANLARALGM 178 Query: 169 RLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVM 228 +L + LE V Y + ++SDV+SLHCPL E ++++EA QMK + Sbjct: 179 HVLFAE---RKGQLECRVGYTSFEQVLAQSDVLSLHCPLMDETRNIISEAELVQMKPNAL 235 Query: 229 IVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH 288 ++NT RG L+D QA ++ALK ++I G+DV+ E D N +I + R L Sbjct: 236 LINTGRGGLVDEQALVDALKRRQIAGAGVDVFSVEP----ADMDNPLIAN---RDLP--- 285 Query: 289 NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 N+L T H A+ + ++ ++ + N+S +GE Sbjct: 286 NLLLTPHVAWGSDSSIQQLATILIDNISAFMRGE 319 >UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID=C9MSC4_9BACT Length = 316 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 90/290 (31%), Positives = 144/290 (49%), Gaps = 28/290 (9%) Query: 39 AKTANGCEAVCIFVND-DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRV 97 AK A+G I +N + + VL++L K +KYI G+NN+D+ AA+ G+ V + Sbjct: 42 AKDADG-----ILINKVNITEEVLQQLPK--LKYIGELATGYNNIDIAAARARGVVVCNI 94 Query: 98 PAYDPEAVAEHAIGMMMTLNRRIH------RAYQRTRDANFSLEGLTGFTMYGKTAGVIG 151 PAY ++VA+H +++ R+ R + + +F + GKT G++G Sbjct: 95 PAYSTDSVAQHVFALLLNAATRVDHYAEAVRRGEWCKQQDFCYWDTPLIELAGKTLGIVG 154 Query: 152 TGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPEN 211 G IG + +I GM + A+ S E + L LFS SDVI+LHCPLT EN Sbjct: 155 LGHIGQKVAQIAHAMGMDISAYTSKNSTDLPEC-IRKTTLEGLFSTSDVITLHCPLTAEN 213 Query: 212 YHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDK 271 H++N ++M+ G +++NT RG LID QA +AL++ + + DV +E K Sbjct: 214 AHMINAERLQKMRPGTILINTGRGGLIDEQAVADALESGHLKAYCADVMTDEP----PRK 269 Query: 272 SNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 N ++Q N T H A+ T EA + ++N+ +G Sbjct: 270 DNPLLQQP---------NAYITPHVAWATREARERLMAIAVENIRKFIEG 310 >UniRef50_UPI00016C4FF9 D-3-phosphoglycerate dehydrogenase n=2 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4FF9 Length = 329 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 91/265 (34%), Positives = 138/265 (52%), Gaps = 23/265 (8%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ IA G++ VDL AA G+ V P + +VAEHA +M+ R I R Sbjct: 73 LRVIARVGVGYDAVDLAAATAAGVAVTIAPGTNQGSVAEHAFALMLGFTRHIP-----AR 127 Query: 129 DANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALEL 184 A S G L + G+T G+ G G+IG A+ + F MR++AFDP+P AA Sbjct: 128 HAALSAGGWNRLMSLPLRGRTLGLAGLGRIGKAVATRARAFEMRVIAFDPFPDAAFCAAT 187 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 GVE V L ESD +SLH PLTPE H++ + MK G ++VNTSRG L+ + Sbjct: 188 GVELVPFERLLGESDFLSLHLPLTPETRHVIRASTIAVMKPGAVLVNTSRGGLVREADLV 247 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 AL++ ++G +DV+E+E D+ R A NV+ T H A + ++L Sbjct: 248 PALQSGRLGGALLDVFEDE----------PTPADNPLR---ALPNVVLTPHAAGVDTQSL 294 Query: 305 TSISQTTLQNLSNLEKGETCPNELV 329 ++++ + +++L +GE P E V Sbjct: 295 EDMARSAAEAIASLRRGE-WPTEKV 318 >UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMX1_SYNFM Length = 525 Score = 135 bits (339), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 84/229 (36%), Positives = 114/229 (49%), Gaps = 17/229 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +N+D+ AA G V+ P + A AEH I MM+ L R I +A Q R Sbjct: 65 LKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALARHIPQATQSMR 124 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAAALELGV 186 + + + G ++ +T G+IG GKIG + M +L DPY P AAA+ LGV Sbjct: 125 EGRWDKKRFMGTELFHQTLGIIGLGKIGSIVADRALSMKMDVLGHDPYIIPEAAAI-LGV 183 Query: 187 EYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 E+V L L + SD ++LH P T E +LN + K GV I+N +RG LID QA E Sbjct: 184 EWVPLDELLARSDFLTLHTPSTSETVRILNRETLARTKPGVRILNCARGGLIDEQALYEF 243 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L N +G +DV+E E V L NV+FT H Sbjct: 244 LLNGHVGGAALDVFEQE--------------PPVDSPLLKLENVIFTPH 278 >UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B6KF90_TOXGO Length = 604 Score = 135 bits (339), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 85/247 (34%), Positives = 127/247 (51%), Gaps = 11/247 (4%) Query: 60 VLEELKKHG--VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V E++ KHG +K I G +NV +DAA G+ VV P + A AE +G+MM L Sbjct: 67 VTEKIIKHGQKLKIIGRAGVGVDNVCVDAATAQGIFVVNSPNGNTMAAAELTLGLMMALA 126 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+I +A ++ G + KT G+IG G++G + R+ GM +LA+DP+ Sbjct: 127 RKIPQADASVSRGEWTRSKFMGRQLNQKTIGIIGLGQVGTHVARVCTALGMEVLAYDPFI 186 Query: 178 S-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + A +G V L TL + SD I+LH PL + HL+N + +K I+N SRG Sbjct: 187 NEEKAKAVGCRNVALETLLASSDFITLHVPLLDKTRHLINADKLKLIKKDACIINASRGG 246 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID +A EAL ++ +DV+E E++ K N +IQ R N++ T H Sbjct: 247 VIDEKAVAEALMANELAGAALDVFEEEKEF---SKDNPLIQAKANGR-----NIILTPHI 298 Query: 297 AFLTAEA 303 T EA Sbjct: 299 GASTLEA 305 >UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTC6_TRIAD Length = 520 Score = 135 bits (339), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 79/267 (29%), Positives = 138/267 (51%), Gaps = 17/267 (6%) Query: 60 VLEELKKHG--VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V E+ K G +K I G +N+D+ AA E G+ V+ P + + AEH +M+ L Sbjct: 57 VTAEVIKAGKNLKIIGRAGTGVDNIDIKAATECGVIVMNTPGGNTLSAAEHTCTLMVCLA 116 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-Y 176 R++ +A R+ + + G + GKT G+IG G+IG + ++ FG+R + +DP Sbjct: 117 RQVPQAAASMREGRWDRKKYMGIELMGKTLGIIGLGRIGREVATRMQSFGVRTVGYDPIV 176 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 P+ AA E VE+ +L L+ E D I++H PL P+ LL + F + K GV ++N +RG Sbjct: 177 PAEAAKEFDVEFFELNDLWPECDFITVHTPLIPQTRGLLGDETFAKCKKGVRVINCARGG 236 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID A + AL++ + +DV+E E ++ +++Q NV+ H Sbjct: 237 IIDEAALLRALQSGQCAGAALDVFEQE-----PPQNTELVQHP---------NVIPVCHL 282 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGET 323 T EA + ++ + + +G++ Sbjct: 283 GASTVEAQSRVAVEIAEQFVDFNEGKS 309 >UniRef50_A4EQ78 Dehydrogenase n=6 Tax=Bacteria RepID=A4EQ78_9RHOB Length = 343 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 85/254 (33%), Positives = 133/254 (52%), Gaps = 11/254 (4%) Query: 72 IALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDAN 131 IA G + VD++AA G+ V V Y E VA+HAI + + L R++ Y R A Sbjct: 82 IARYGVGVDIVDVNAATAKGILVTNVQNYCTEEVADHAIALWLALARKLPD-YDRATHAG 140 Query: 132 FSL--EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEY 188 G + G+T GV+ GKIG A+ + FG+ ++A+DP+ P AA +LGVE Sbjct: 141 LWQWQSGQPVHRLRGRTMGVVSLGKIGQAIAARARAFGVNVIAYDPFLPGEAAAKLGVEL 200 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V P L + SD I + P+TP+ +H L++A F MK G ++VNT RG +D++A AL Sbjct: 201 VGKPELLARSDYILMQAPMTPDTHHFLSDAEFAAMKPGAILVNTGRGPTVDNKALFRALT 260 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 + + G+D E E ++N D++ L NVL T H A+ + E++ + Sbjct: 261 EGHLAAAGLDDPEEEP----AKRANWTPDDNLLFTLP---NVLVTPHAAYYSEESILAAR 313 Query: 309 QTTLQNLSNLEKGE 322 T ++ + G+ Sbjct: 314 VTAATQVAKVLTGQ 327 >UniRef50_Q8EP33 Glycerate dehydrogenase n=2 Tax=Bacillaceae RepID=Q8EP33_OCEIH Length = 314 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 85/252 (33%), Positives = 126/252 (50%), Gaps = 18/252 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +KYI AG++N+D A+E G+ V P + +AVA+ AIG+M+ R I + R Sbjct: 70 LKYIMKFGAGYDNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELR 129 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + N+ L G ++ K G+IG G IG A+ + GF M +LA+ + A L VE Sbjct: 130 NGNWELS--MGIEIFQKKLGIIGFGAIGQAIAQRATGFQMEVLAYGTFQDQTIADRLNVE 187 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 +VDL L +ESD++ + L +NY L+N ++K + +N SRGAL+D A EAL Sbjct: 188 FVDLNKLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDEDALYEAL 247 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 N KI G+DV F E+ S+ L N T H T EA+ Sbjct: 248 TNGKIKGAGLDV-------FVEEPSH--------HPLLTLPNTTVTPHIGAATNEAIKRT 292 Query: 308 SQTTLQNLSNLE 319 L+N+ L+ Sbjct: 293 GSVALENVQRLK 304 >UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A9WCW3_CHLAA Length = 525 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 73/196 (37%), Positives = 111/196 (56%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ I G +N+D++AA G+ VV PA + AVAE IG++++L RRI +A+ + Sbjct: 64 LRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAHASLQ 123 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALELGVE 187 ++ G+ + GKT G++G G+IG + R + M +LA+DP S A +LGV Sbjct: 124 SGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQLGVS 183 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V L L SDVISLH PL +L ++ QMK G ++N SRG ++D A +EAL Sbjct: 184 LVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVALVEAL 243 Query: 248 KNQKIGSLGMDVYENE 263 + +G +DVY E Sbjct: 244 NSGHLGGAALDVYNQE 259 >UniRef50_Q1GAM7 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 RepID=Q1GAM7_LACDA Length = 322 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 88/267 (32%), Positives = 136/267 (50%), Gaps = 21/267 (7%) Query: 56 GSRPVLEELKKHG--VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 G PV +EL G +K ++ G++++D+D A G+ V PA + AE A ++ Sbjct: 56 GKLPVDQELLDAGKKLKIVSATGVGYDHIDVDYASSQGIIVSNCPASVMQPTAEMAFTLL 115 Query: 114 MTLNRRIHRAYQRTRDANFSLEGL---TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 + L+R++ Q R NF GL G + GKT G+ G G+IG + + FGM + Sbjct: 116 LALSRKLALYNQEMRQENFLDTGLLENQGQSPVGKTLGIFGMGRIGKTLASYARTFGMNI 175 Query: 171 LAFDPY--PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVM 228 L + + P LGV YV L L S++D +SL+ P T E YH+++EAA M+ Sbjct: 176 LYHNRHQLPEDEERALGVSYVPLADLLSQADYVSLNAPATAETYHVIDEAALSMMQPTAF 235 Query: 229 IVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH 288 ++NTSRG+ +D A + ALK ++I G+DV+E E D E F +L Sbjct: 236 LINTSRGSQVDEAALLRALKGKRIAGAGLDVFEEEPDFNKE-----------FCQLD--- 281 Query: 289 NVLFTGHQAFLTAEALTSISQTTLQNL 315 NV+ T H T E+ S+ + N+ Sbjct: 282 NVILTPHAGSATRESRRSVLKEASHNI 308 >UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2G1_9PLAN Length = 316 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 88/261 (33%), Positives = 129/261 (49%), Gaps = 17/261 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA AG +NVD + A E G+ V P + +VAE IG+M+ L R+I A Q T Sbjct: 66 LKIIARAGAGLDNVDTEYAHEKGIVVCFTPDANSLSVAELTIGLMLALMRKIPEARQDTL 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE---LG 185 ++ TG +YGK+ G+IG G+IG K FGM +LA DP+ A A + L Sbjct: 126 TGGWNRLKFTGTELYGKSFGLIGLGRIGSFTATRAKAFGMNILAADPFLKADAPQLKKLN 185 Query: 186 VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 + L L +ESDV+S H PLTP+ +L F +MK +NTSRG ++D + + Sbjct: 186 ATLLSLDDLLAESDVVSCHSPLTPDTRKMLTYQHFRKMKPDAFFINTSRGEVVDERGLTQ 245 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 AL K+ +DV E E K + L+ NV+ T H A T EA Sbjct: 246 ALLEHKLAGAALDVRETE-----PPKQSP---------LNQMENVILTPHIAAFTVEAQD 291 Query: 306 SISQTTLQNLSNLEKGETCPN 326 + + +++ + G+ N Sbjct: 292 RVVDSVCEDVRLVLSGKKAIN 312 >UniRef50_Q7MHE8 Lactate dehydrogenase n=12 Tax=Proteobacteria RepID=Q7MHE8_VIBVY Length = 320 Score = 134 bits (338), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 89/278 (32%), Positives = 142/278 (51%), Gaps = 22/278 (7%) Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 + VL +L ++ IA+ GFNNVD+D E G+ V V Y +V EH I M+ L Sbjct: 59 QAVLAQLPN--LRMIAVAATGFNNVDVDFCAEKGIAVANVRGYATRSVPEHVIAMLFALR 116 Query: 118 RRIHRAYQ------RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 R + +Q +D F + G T G+IG+G +G A ++ + G+++L Sbjct: 117 RNLFGYHQDIAAGVWQQDKQFCFFSHPIGDVAGSTLGIIGSGTLGQATAQLAQALGVKVL 176 Query: 172 AFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVN 231 F + G Y + S++D ISLHCPL+ + +HL+ A MK+ +++N Sbjct: 177 -FAERKGQSDCRQG--YHRFEEVLSQADAISLHCPLSAQTHHLIGAAELASMKSNAILLN 233 Query: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVL 291 T RG L+D QA +EALK I + G+DV+ E D+SN ++ + N+L Sbjct: 234 TGRGGLVDEQALVEALKKGDIAAAGVDVFSAEP----ADESNPLLAN------MHLPNLL 283 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 T H A+ + A+T + + L+N++ +GET N LV Sbjct: 284 LTPHVAWGSDSAITQLCEILLENINAYWRGETL-NRLV 320 >UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973D95 Length = 322 Score = 134 bits (337), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 4/203 (1%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + G+K I AGF++VD++AA + G+ V P + AV+E A+ +M+ + R + Sbjct: 61 RNKGLKMIIRWGAGFDSVDIEAAGKNGVVVANTPGANAPAVSELAVMLMLAVGRHLIDHM 120 Query: 125 QRTRDANFSLEGLT--GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAA 180 R +S +T+ K G+IG G IG + + FG + +DP+ Sbjct: 121 DSLRKGVWSKNTYINQSYTLNRKLVGIIGAGNIGRQTAKKAQAFGAEIQYYDPFRLSPER 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ELG+ YV L TL SDVISLH PLT N H++ QMK+G ++VNT+RG L+D Sbjct: 181 EQELGLRYVPLETLLKTSDVISLHVPLTDSNRHMIGAEEISQMKDGAILVNTARGGLVDD 240 Query: 241 QAAIEALKNQKIGSLGMDVYENE 263 QA EA+++ K+ G+DV ENE Sbjct: 241 QALAEAVRSGKLAGAGLDVVENE 263 >UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planctomycetaceae RepID=C1ZMC1_PLALI Length = 546 Score = 134 bits (337), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 78/261 (29%), Positives = 137/261 (52%), Gaps = 4/261 (1%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T L+ + E+ G E++ L ++ + + + I + +L++ Sbjct: 4 VLITDNLSPAGLKILKETPGIEVDLRKGLTPDEVRVALHDADGIIIRSETKLTPEILKDQ 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K I G +N++L AA G+ V+ PA + + AEH I MMM L+R I A Sbjct: 64 PR--LKAIVRAGVGTDNINLPAATREGIVVMNTPAGNTTSTAEHTIAMMMALSRNIAPAA 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + RD + + TG + GK+ ++G G+IG+A+ R G M++L FDP+ S A E Sbjct: 122 SKLRDGVWDRKSFTGTQLAGKSIAIVGLGRIGLAVARRAMGLEMKVLGFDPFMSVERAAE 181 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 G+E Y D+ + ++ D +++H PL+PE +L+ +MK GV I+N +RG +I+ Sbjct: 182 QGIELYRDIDEMITKCDYLTVHTPLSPETTNLIGAERLAKMKKGVRIINCARGGIINEAE 241 Query: 243 AIEALKNQKIGSLGMDVYENE 263 +A+++ IG +DV+ E Sbjct: 242 LAQAIESGHIGGAALDVFVKE 262 >UniRef50_B9ML91 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Clostridiales RepID=B9ML91_ANATD Length = 365 Score = 134 bits (337), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 92/260 (35%), Positives = 133/260 (51%), Gaps = 17/260 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 VK I + AG NV++ A + G+ V V + EAV++ AIG+++ R I RA+ + Sbjct: 96 VKIIGVSRAGLENVNVKEATQRGVLVFNVQGRNAEAVSDFAIGLLLAECRNIARAHYAIK 155 Query: 129 DANFSLEGLTG---FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL-EL 184 + + E + GKT G+IG G IG + + L GF +R L +DPY S + E Sbjct: 156 NGQWRKEFSNSDWIPELKGKTVGIIGFGYIGRLVAKKLSGFEVRRLVYDPYVSEEEIREC 215 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 G VD TLF ESD I+LH LT EN +L+ + MK I+NT+R LID +A I Sbjct: 216 GCIPVDKETLFKESDFITLHARLTEENKNLVGKYEISLMKPTAYIINTARAGLIDKEALI 275 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 EALK ++I +DV F+E+ I D L NV T H A T EAL Sbjct: 276 EALKTKRIAGAALDV-------FWEEP----IPSD--SELLELDNVTLTSHLAGTTKEAL 322 Query: 305 TSISQTTLQNLSNLEKGETC 324 T + ++++ +G+ Sbjct: 323 TRSPELLMEDVKKFIEGQKA 342 >UniRef50_C6XUZ4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Sphingobacteriaceae RepID=C6XUZ4_PEDHD Length = 307 Score = 134 bits (337), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 79/250 (31%), Positives = 131/250 (52%), Gaps = 8/250 (3%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K+IA AG +N+D AK G+K++ P + +AV EHAIGM++ L A R Sbjct: 66 LKFIARAGAGLDNIDEAFAKLKGIKLLNAPEGNMDAVGEHAIGMLLALMNNFRNADTEVR 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 + EG G+ + GKT G+IG G +G + + L GF + ++A+D Y + + E Sbjct: 126 KGVWDREGNRGYELKGKTVGIIGYGFMGKSFAKKLSGFDVHVIAYDKYKTGFSDAYARE- 184 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V + + +SDV+SLH PLTPE ++NE + + +NT+RG ++ ++A ++A+ Sbjct: 185 VSMEEIVKQSDVLSLHIPLTPETRQMVNEEYLFHFRKPLFFINTARGEVVSTEAVLKAIA 244 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 KI G+DV E E+ F SN + + L V+ T H T ++ IS Sbjct: 245 QGKILGAGLDVLEVEK---FPALSN----QEWYNALKLAEKVVLTPHVGGWTFDSYRKIS 297 Query: 309 QTTLQNLSNL 318 + + L ++ Sbjct: 298 EVLAEKLKDI 307 >UniRef50_C2ESK5 NAD binding D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Lactobacillus vaginalis ATCC 49540 RepID=C2ESK5_9LACO Length = 309 Score = 134 bits (336), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 86/256 (33%), Positives = 129/256 (50%), Gaps = 20/256 (7%) Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE- 135 AG++NVD+ G+KV + AV EH + ++++ + I +D + + Sbjct: 70 AGYDNVDVAECTHRGIKVCNAAGVNANAVVEHTLALILSWFKNIPYLDCFMKDQQPASQL 129 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLF 195 G + GKT G++G G +G M I M +LA++ +P + GV VDLPTL+ Sbjct: 130 TYNGAEIAGKTLGIVGLGNVGARMAHIGLALNMNVLAYNHHPRHIS---GVRMVDLPTLY 186 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 SD+ISLH TP +HL+N AF+QMK+ ++VNTSRG+++D A I AL+ +I Sbjct: 187 KNSDIISLHIAATPATHHLINSQAFQQMKSSALLVNTSRGSIVDEAALISALQTHEIAGA 246 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTL--Q 313 +DV+E E + D R LS NV+ T H A L + + Sbjct: 247 CLDVFEQE----------PLPMDSPLRHLS---NVILTPHTAGLPDSVKFHRRRYEFFKE 293 Query: 314 NLSNLEKGETCPNELV 329 NL+ KGE P LV Sbjct: 294 NLTRFAKGEK-PKNLV 308 >UniRef50_A9BFL0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=60 Tax=cellular organisms RepID=A9BFL0_PETMO Length = 342 Score = 134 bits (336), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 92/265 (34%), Positives = 143/265 (53%), Gaps = 18/265 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPA-YDPEAVAEHAIGMMMTLNRRIHRAYQRT 127 VK IA G+NNVD+ AA E G+ V RV ++ ++VAE A+ +++ R+I A + Sbjct: 76 VKLIARHGIGYNNVDIKAATESGVMVTRVLGIHERDSVAELAVALILICLRQIIPANKAV 135 Query: 128 RDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAAALE-L 184 + + + G + T G+IG G IG + I K GFG ++A+DPY + +E Sbjct: 136 EEYKWQDRKNFVGDELSKLTVGIIGYGNIGSRVAEIAKEGFGSEVIAYDPYIADKVIEKT 195 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 GV V L SDVISL+ L NYH +N++AF MKNGV+IVNT+RG LI+ I Sbjct: 196 GVTPVSFEELLKTSDVISLNASLNEGNYHFINKSAFNLMKNGVVIVNTARGELINQNDFI 255 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 EAL+++K+ + G+DV E E + +N +++ NV H +L Sbjct: 256 EALESKKVSAAGLDVLEEEPI----NPNNPLLK---------YPNVFILPHIGGYGKYSL 302 Query: 305 TSISQTTLQNLSNLEKGETCPNELV 329 + + ++++ L KGE P ++V Sbjct: 303 RKMDEKMVEDIEKLMKGE-IPEQIV 326 >UniRef50_Q0SCM8 Phosphoglycerate dehydrogenase n=2 Tax=Rhodococcus RepID=Q0SCM8_RHOSR Length = 316 Score = 133 bits (335), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 87/255 (34%), Positives = 135/255 (52%), Gaps = 22/255 (8%) Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDAN---FSL 134 GF+NVDLDAA LG++V VP Y + VA+HA+ + + L R++ + + R A + Sbjct: 75 GFDNVDLDAATRLGVRVCNVPDYGADTVADHAVTLTLMLLRKVAQ-FDRALAAGGWPSAT 133 Query: 135 EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAAALELGVEYVDLP 192 E + T G++GTG+I +A+ + L+ FG L+A DPY P AA + G+ VDL Sbjct: 134 ELAPIRSTSETTVGLLGTGRIALAVAKRLQPFGFDLIAHDPYANPDVAA-DHGITLVDLD 192 Query: 193 TLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKI 252 LF S +SLH P T + ++N +M G +VNTSRGAL++ A ++AL + + Sbjct: 193 ELFRRSHALSLHAPATADTRGIVNADNLAKMPFGSFLVNTSRGALVEQDAVLDALDSGAL 252 Query: 253 GSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTL 312 +G+DV+ E + D RL A N + T H AF + ++L + + Sbjct: 253 AGVGLDVFHPEP-----------LAPD--HRLRAHPNAVLTPHAAFYSEQSLRDLQRLAA 299 Query: 313 QNLSNLEKGET--CP 325 + S +GE CP Sbjct: 300 EEASRAIRGEPLRCP 314 >UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HZG9_9BACT Length = 537 Score = 133 bits (335), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 69/196 (35%), Positives = 112/196 (57%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I AG +NVDL AA G+ V+ P + AEH + MMM++ RRI +A R Sbjct: 70 LKVIGRAGAGLDNVDLPAATNRGIVVMNTPGGNTITTAEHTVSMMMSMARRIPQANASNR 129 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVE 187 + G + KT G++G GKIG + + +G M ++A+DP+ +A +A GV Sbjct: 130 SGKWEKSKFMGIELAHKTLGILGMGKIGSHVAHVAQGLLMNVIAYDPFLTAESAARQGVT 189 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V + LF+++D+I++H PLTPE +L++ A+ +MK GV IVN +RG +++ +AL Sbjct: 190 PVTVEELFAKADIITVHTPLTPETTNLISSASIAKMKKGVYIVNCARGGIVNEADLAKAL 249 Query: 248 KNQKIGSLGMDVYENE 263 ++ + DV+ E Sbjct: 250 ESGHVAGAAFDVFAEE 265 >UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=bacterium Ellin514 RepID=B9XQY4_9BACT Length = 334 Score = 133 bits (335), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 128/254 (50%), Gaps = 15/254 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I+ GF+ +D+ +A G+ + P E+VA++ +G+++ L RRI Y+ Sbjct: 74 LKLISRWGVGFDAIDVTSATREGILITYTPGMTDESVADYTMGLLLALVRRIIDGYETMS 133 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 + + G M GKT G++G G+IG A+ R KGFG+ L+A DP+P + G ++ Sbjct: 134 KGLW--QPAWGHDMNGKTLGILGYGRIGQAVARRAKGFGLELIAHDPHPPMGTDQFGTQF 191 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V L SD +SLH LT L+ EA ++MK ++N +RG L++ QA I AL Sbjct: 192 VSFNELLERSDYLSLHATLTSSTRDLIGEAQLQKMKPSAYLINAARGPLVNEQALIRALN 251 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 I +D + E + D FRR N+L + HQA + E+ IS Sbjct: 252 EGWIAGAALDAFTVE----------PLPVDHPFRR---TPNLLLSPHQASSSRESGELIS 298 Query: 309 QTTLQNLSNLEKGE 322 T Q + +L G+ Sbjct: 299 LATAQAVLDLMAGK 312 >UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Thermoanaerobacter RepID=B0K2Z0_THEPX Length = 324 Score = 133 bits (335), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 84/272 (30%), Positives = 141/272 (51%), Gaps = 18/272 (6%) Query: 45 CEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEA 104 +A+ + +R V+E +K I+ AG +N+D++AA E G+ V +PA + + Sbjct: 42 VDAIILRTRSKITREVIENAPH--LKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLS 99 Query: 105 VAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLT-GFTMYGKTAGVIGTGKIG-VAMLRI 162 VAEH I M++ L++++ + R N+ + GK G++G G IG + + Sbjct: 100 VAEHTIAMILNLSKQLSLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKC 159 Query: 163 LKGFGMRLLAFDPYPSAAALELGVEYVDL-PTLFSESDVISLHCPLTPENYHLLNEAAFE 221 G GM+++A+DPY ++VD LF ESD ++LHCP PE ++ Sbjct: 160 HDGLGMKIVAYDPYVKEKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIY 219 Query: 222 QMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVF 281 MK+ ++N +RG +ID QA IEALK ++I G+DV++ E S+D +++ Sbjct: 220 SMKHTAYLINAARGTVIDEQALIEALKEKRIAGAGLDVFQQ------EPPSSD---NELL 270 Query: 282 RRLSACHNVLFTGHQAFLTAEALTSISQTTLQ 313 R NV+ + H A LT EA ++ +Q Sbjct: 271 R----LENVILSPHSAALTKEATVRMAVEAVQ 298 >UniRef50_A6CXX0 Dehydrogenase n=1 Tax=Vibrio shilonii AK1 RepID=A6CXX0_9VIBR Length = 337 Score = 133 bits (335), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 84/260 (32%), Positives = 136/260 (52%), Gaps = 12/260 (4%) Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R +E+L K I G + +D++A + G+KV VP Y + VA+H+I + +TL Sbjct: 63 RTTIEQLDN--CKIICRYGIGVDILDVEACYDHGIKVSNVPDYCIDEVADHSISLGLTLF 120 Query: 118 RRI--HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 RRI + + ++ ++GL T G+IG G+I + + + G ++++FDP Sbjct: 121 RRIPAYNKFTHEGQWHWDIDGLVPKRFRSSTWGLIGFGRIAQNIAKKMTALGFKVISFDP 180 Query: 176 YPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 Y S + + GVE VDL TL S SDV+++ CP TPE L+NE QMK+ ++VN +R Sbjct: 181 YVSGSYMNTFGVEKVDLDTLISTSDVVNVMCPHTPETDRLINEDRLRQMKSNAVLVNGAR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D++A +AL I S G+D E E ND + +F N + T Sbjct: 241 GKVVDNKALYKALVEGWIASAGLDDPEEEPAKLDNWNPND---NPIF----GLDNCIVTP 293 Query: 295 HQAFLTAEALTSISQTTLQN 314 H A+++ EA + +N Sbjct: 294 HVAYVSQEAFQECRRIAAEN 313 >UniRef50_B3E5B4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=21 Tax=Bacteria RepID=B3E5B4_GEOLS Length = 332 Score = 133 bits (334), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 84/269 (31%), Positives = 138/269 (51%), Gaps = 21/269 (7%) Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +L++L G+++I+L G+NNVD++AA LG+ V VPAY ++VA+ +++ L Sbjct: 63 ILQQLP--GLRFISLLATGYNNVDVEAAGRLGITVSNVPAYSTDSVAQTTFALLLELTTH 120 Query: 120 --IH----RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 +H + + R + S + G T G++G G IG A+ RI FGM+++A+ Sbjct: 121 AGLHDQAVKQGEWVRSPDHSFWKRPIVELAGLTLGIVGFGAIGRAVARIGSAFGMQVVAY 180 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 P P AA V +V L LF ++DV+SL+CP T EN +N E+MK ++N + Sbjct: 181 TPRPPAATEFPLVRFVSLDELFGQADVVSLNCPQTTENGGFVNAVLLERMKRSAFLINVA 240 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG L++ AL++ I G+DV E L N ++Q N +FT Sbjct: 241 RGGLVNESDLAAALRDGVIAGAGLDVVSVEPML----PENPLLQ---------APNCIFT 287 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGE 322 H A+ + A ++ NL+ +G+ Sbjct: 288 PHIAWASLAARQRLTAIVAANLAGYLQGK 316 >UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cellular organisms RepID=A7IAB7_METB6 Length = 534 Score = 133 bits (334), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 76/241 (31%), Positives = 124/241 (51%), Gaps = 15/241 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +++I G +NVD+DAA G+ V P + A EH + MM++L R I +A + Sbjct: 66 LRFIGRAGVGVDNVDVDAATRQGVIVANAPEGNTLAATEHTMAMMLSLARNIPQANASLK 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + G + KT G++G G+IG + + M+ +A+DP+ S A +LGV Sbjct: 126 KKEWKRSKFMGVELNEKTLGIVGFGRIGREVAKRANAMDMKCVAYDPFISKERAAQLGVR 185 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + L LF+ +DVI++H PL E H++N + MK+GV I+N +RG +ID A ++A+ Sbjct: 186 VMSLAELFTVADVITVHTPLIKETKHVINAKSIATMKDGVRIINCARGGIIDEAALVDAI 245 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K+ K+ +DV+E E L L + NV+ T H T EA ++ Sbjct: 246 KSGKVAGAALDVFETEPPL--------------ESPLLSLDNVIVTPHLGASTVEAQKNV 291 Query: 308 S 308 + Sbjct: 292 A 292 >UniRef50_A6ULR7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Sinorhizobium medicae WSM419 RepID=A6ULR7_SINMW Length = 328 Score = 133 bits (334), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 75/208 (36%), Positives = 120/208 (57%), Gaps = 15/208 (7%) Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 P L + +HGV G+NNVD+++A G+ V+ + ++VAE A+G+ +++ R Sbjct: 66 PALRVISRHGV--------GYNNVDIESATRRGVPVLIADGANGKSVAELAVGLALSVAR 117 Query: 119 RI--HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 +I A R R N S GL GKTAG++ G IG + IL+ MR++AFDP+ Sbjct: 118 KITTQDASIRARQWNRSAYGLQ---FAGKTAGIVAFGAIGRRVAEILRAMDMRIIAFDPH 174 Query: 177 PSAAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 + GV++ + L L ESD++SLHCPLTPE +++ +MK G +++NT+RG Sbjct: 175 ARDRSTT-GVDWTETLDELLQESDLVSLHCPLTPETRNMITAPRLARMKPGAILINTARG 233 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENE 263 LID +A EA+ + + G+D + +E Sbjct: 234 GLIDEKALAEAVLSGHLAGAGLDTFADE 261 >UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=A2STQ1_METLZ Length = 527 Score = 133 bits (334), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 66/196 (33%), Positives = 109/196 (55%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +KYI G +N+D +AA + G+ V P + A EH I MMM + R I +A + Sbjct: 65 MKYIGRAGVGVDNIDCEAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQASASLK 124 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVE 187 + G M GK GV+G G+IG + + + M ++A+DP+ P+ +GVE Sbjct: 125 KGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAEVGAAMGVE 184 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + + LF+++DVI++H PL P HL+N+ + MK GV ++N +RG +ID + +A+ Sbjct: 185 MMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDLYDAI 244 Query: 248 KNQKIGSLGMDVYENE 263 + K+ +DV+E E Sbjct: 245 VSGKVAGAALDVFETE 260 >UniRef50_Q9BLF6 D-lactate dehydrogenase n=1 Tax=Octopus vulgaris RepID=Q9BLF6_OCTVU Length = 324 Score = 133 bits (334), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 83/259 (32%), Positives = 138/259 (53%), Gaps = 17/259 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K ++ G+ ++DL A K + + + V+E A+ + + ++RRI R Sbjct: 72 LKVVSTLSVGYEHIDLKACKARNIIACNLSKISTDCVSEFAVTLALAVSRRIEEGIAAVR 131 Query: 129 DANFSLE---GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGM-RLLAFDPYPSAAALEL 184 + ++ L + G + +T GV+G G+IG + R +K F + RL+ D S+ A EL Sbjct: 132 NGSWGLWKPMWILGSSFANRTIGVLGMGRIGYGVARRMKAFCISRLIYHDIKESSFAQEL 191 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 G E+VDL TL +SDVI + C LTP ++L N+ F++MKN +++NTSRG +I+ Sbjct: 192 GAEFVDLETLLKDSDVICICCNLTPATHYLFNKENFKKMKNTAILINTSRGGVINHDDLY 251 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 +ALKN +IG+ G+DV E E L E RL++ N + T H T EA Sbjct: 252 DALKNHEIGAAGLDVTEPE-PLPKE------------HRLNSLPNCVVTLHMGSNTWEAR 298 Query: 305 TSISQTTLQNLSNLEKGET 323 ++S N+ ++ + +T Sbjct: 299 NNMSYNAALNIDSVFENQT 317 >UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6VZ76_DYAFD Length = 337 Score = 132 bits (333), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 89/265 (33%), Positives = 138/265 (52%), Gaps = 16/265 (6%) Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R +LE K +++IA AG + +DL+ A+EL ++V + +AVAEHA+GM++ L Sbjct: 84 REMLENAKN--LRFIARAGAGLDLIDLNVARELNIEVFHAGTGNRDAVAEHALGMLLALF 141 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 I RA Q+ R+ + EG G + GKT G+IG G G A + L GFG ++LA+D Y Sbjct: 142 TNILRADQQVRNGIWDREGNRGVELMGKTVGLIGYGNNGSATAKRLSGFGCKVLAYDKYR 201 Query: 178 ----SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 A A E +E + E+D+ISLH PLT L+N+ ++N S Sbjct: 202 DQYGDAFAAESSIEEIQ-----READIISLHIPLTDITRQLVNDEFISAFAKPFYLLNLS 256 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG ++ +A AL++ KI +DV ENE+ + Q +VF L + V+ T Sbjct: 257 RGEVVQLKAVTSALESGKIKGACLDVLENEKIGKLTPE-----QQEVFDYLKSSDRVVLT 311 Query: 294 GHQAFLTAEALTSISQTTLQNLSNL 318 H A T E+ I++ ++ + N Sbjct: 312 PHIAGWTHESYVRINEVLVEQIRNW 336 >UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms RepID=GYAR_THEON Length = 334 Score = 132 bits (333), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 81/267 (30%), Positives = 136/267 (50%), Gaps = 24/267 (8%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K +A G++N+D++ A ++G+ + P A A+ A +++ RR+ A + R Sbjct: 68 LKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIEADKFVR 127 Query: 129 DANFSLEGLT-------GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL--AFDPYPSA 179 + G+ G+ +YG+T G++G G+IG A+ R KGFGMR+L + P Sbjct: 128 SGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILYNSRTRKPEV 187 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ELG E++ L L ESD + L PLT E YH++NE + MK ++VN +RG ++D Sbjct: 188 EK-ELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIARGKVVD 246 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A ++AL+ I G+DV+E E + E+ L + NV+ H Sbjct: 247 TEALVKALREGWIAGAGLDVFEEE-PYYHEE-------------LFSLDNVVLAPHIGSA 292 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPN 326 T A +++ +NL + GE P Sbjct: 293 TYGAREGMAELVARNLIAFKNGEVPPT 319 >UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V5E1_9FIRM Length = 334 Score = 132 bits (333), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 84/272 (30%), Positives = 137/272 (50%), Gaps = 17/272 (6%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V+E L +K IA G N VDL+AA E G+ V+ VP Y + V+ HA ++M Sbjct: 57 TRRVIEALPH--LKVIARYGVGVNTVDLEAATEHGVCVLNVPDYCADEVSNHAFALLMAC 114 Query: 117 NRRIHRAYQRTRDANFSLEGLTGF-TMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 +R++ + + + + G+T G++G G+I + + FG++ +DP Sbjct: 115 HRKLAPLHTQVNGGGWDYNICKPIHRLAGQTLGLLGFGRIPRLLAEKARAFGLKFAVYDP 174 Query: 176 YPSAAAL-ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + + A + G + + L + SD+IS+H PLT E HLL+ F+ MK +++NTSR Sbjct: 175 FVTPAIVASYGGKLLTLGEVLQASDMISVHVPLTKETEHLLSHREFDMMKPSTILINTSR 234 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G LID +A AL KI + G+DV E E + QD R L N++ T Sbjct: 235 GPLIDEEALYAALTQGKIAAAGLDVTEQE----------PLAQDSPLRSLP---NIIITP 281 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 H A+ + EA + + ++++ G PN Sbjct: 282 HAAWYSEEAECELKTKAARGIADILSGHDLPN 313 >UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NG91_EUBSP Length = 319 Score = 132 bits (333), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 87/259 (33%), Positives = 130/259 (50%), Gaps = 33/259 (12%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH------- 121 +K I+ G++ VD++AA G+ V P + ++VA+ A+ +M+ R + Sbjct: 73 LKVISRYGVGYDKVDVEAADRKGILVTITPGANGDSVADLAVTLMLDAARNVAAMDAAMK 132 Query: 122 -RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA R + G M+ KT GVIGTG+IG + R KGF M++L +D Y + A Sbjct: 133 GRAQARPQ----------GVEMWQKTLGVIGTGRIGQGVARRCKGFDMKILCYDIYENEA 182 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E +YVDL TL ESD I++H PLTPE ++ F+ MKN +IVNT+RG +I+ Sbjct: 183 FKKECNAKYVDLSTLLRESDFITIHSPLTPETKDMIGAREFDMMKNDAVIVNTARGGIIN 242 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A EALK+ I G+D +E D L C + T H Sbjct: 243 EEALYEALKSGSIRGAGLDATVDEPPY-----------DSPLMTLPNC---ILTPHAGAA 288 Query: 300 TAEALTSISQTTLQNLSNL 318 T EA + +S QN+ ++ Sbjct: 289 TKEASSKMSLMAAQNVVDV 307 >UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Arthrobacter aurescens TC1 RepID=A1RDF9_ARTAT Length = 329 Score = 132 bits (332), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 91/251 (36%), Positives = 129/251 (51%), Gaps = 19/251 (7%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 + P L+ + +HGV G +NVD+ AA E + V P + AVAEH ++++L Sbjct: 59 ASPRLKIIARHGV--------GTDNVDIPAASEHSVWVTSTPGSNSNAVAEHVFSLLLSL 110 Query: 117 NRRIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 RRI A R ++ EG L GF + G+T G++G G IG + I GFGMR+LA Sbjct: 111 TRRIIPAANRVLAGTWA-EGRGDLVGFELSGRTLGIVGFGAIGKRVATIANGFGMRVLAS 169 Query: 174 DPYPSAAALELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 DP +AA E V+L TL+ +D+I+LH PL H+++ MK +I+NT Sbjct: 170 DPIATAADAEAAGAVLVELDTLYDGADIITLHAPLLSGTRHMISPRELAMMKPSAIIINT 229 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 SRG LID A + AL N + +DV E E D + + + V L N+L Sbjct: 230 SRGGLIDEDALVTALTNGTLAGAALDVLEAES----IDMKDPLTHNSV--PLHEVPNLLV 283 Query: 293 TGHQAFLTAEA 303 T H A T EA Sbjct: 284 TPHIAGQTQEA 294 >UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n=11 Tax=Bacteria RepID=A0Q365_CLONN Length = 317 Score = 131 bits (330), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 82/253 (32%), Positives = 130/253 (51%), Gaps = 13/253 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I++ G ++VD A E + V Y +VAE G++ ++ R I + TR Sbjct: 71 LKMISVAFTGIDHVDTKACTEKQVMVCNAAGYSTSSVAELTYGLIFSVLRNIVPLDKATR 130 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 + + G + + GKT G++GTG IG+ + +I K FG +LA+ A++ G +Y Sbjct: 131 EGK-TRNGFSQNEILGKTIGIVGTGAIGIRVGQIAKAFGCNVLAYSRSERKEAIDTGFKY 189 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V L L S+SD++SLH PL E L+++ E MK+ +++NT+RG ++D+ A EALK Sbjct: 190 VSLDELLSKSDIVSLHVPLNDETKGLISKEKIELMKSSSILINTARGPVVDNSALAEALK 249 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 KI G+DV+E E + E L NV+ T H AF T EA+ Sbjct: 250 KGKIKGAGIDVFEIEPPISKE------------HPLFNAPNVVVTPHIAFATEEAMYRRC 297 Query: 309 QTTLQNLSNLEKG 321 + +N+ G Sbjct: 298 EIVFKNIEKWLDG 310 >UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A5G1V9_ACICJ Length = 528 Score = 131 bits (330), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 84/254 (33%), Positives = 126/254 (49%), Gaps = 23/254 (9%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +NVD+ +A G+ V+ P + AEHAIG+M L R + A T+ Sbjct: 65 LKVIGRAGIGVDNVDVKSATARGVVVMNTPYGNAITTAEHAIGLMFALARELPEASASTK 124 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + G + GKT G+IG G IG + G MR+LA+DPY + A A LGVE Sbjct: 125 AGKWEKNRFMGVELTGKTLGLIGAGNIGSIVADRALGLKMRVLAYDPYLTEARATTLGVE 184 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 DL T+ + +D I+LH PLT + ++L+ + + K GV I+N +RG L+D A +AL Sbjct: 185 KADLDTVLARADFITLHTPLTEQTRNILSRESIARTKPGVRIINCARGGLVDEAALYDAL 244 Query: 248 KNQKIGSLGMDVYE----NERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 K+ + +DV+E E LF A NV+ T H T EA Sbjct: 245 KSGHVAGAALDVFEVEPAKESPLF------------------ALPNVVCTPHLGAATTEA 286 Query: 304 LTSISQTTLQNLSN 317 +++ + +S+ Sbjct: 287 QENVALQVAEQISD 300 >UniRef50_A7NGZ0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Roseiflexus RepID=A7NGZ0_ROSCS Length = 345 Score = 131 bits (330), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 93/296 (31%), Positives = 145/296 (48%), Gaps = 31/296 (10%) Query: 41 TANGCEAVCI--FVNDDGSR-----PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLK 93 T G A I +N DG+ P L + + G+ G +N+DL AA E G+ Sbjct: 43 TLPGSAAAIISAMINADGAWMDRAGPTLMAIARPGI--------GVDNIDLAAATERGIL 94 Query: 94 VVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTG 153 V+ P E+ AEHA+ +++ L +++ A R R A +S L G + GKT GV+G G Sbjct: 95 VINTPDGPTESTAEHAVALVLALAKQVVAADHRFRTAGWSAARLRGVEVRGKTLGVVGLG 154 Query: 154 KIGVAMLRILK-GFGMRLLAFDPY-PSAAALELGVEYVD-LPTLFSESDVISLHCPLTPE 210 +IG + +I + G GMR+ A+DP P+ A L V +V+ L L +S+ ++LHC LTP Sbjct: 155 RIGRRVAQICRQGLGMRVAAYDPLAPAEAFAALDVVHVETLDNLLPQSEFLTLHCALTPS 214 Query: 211 NYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFED 270 L+ + G ++N SRGA+ID A I+AL + G+DV++ E Sbjct: 215 TRGLIGARELALLPKGAFLINVSRGAVIDQAALIDALTTGHLAGAGLDVFDP------EP 268 Query: 271 KSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 ND L +V+ T H A T + + + + + L +GE P+ Sbjct: 269 LPND-------HPLLQFPHVILTPHIASFTDDGVRVMHHGAVAQIVRLLRGEHPPH 317 >UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cellular organisms RepID=Q2G4V7_NOVAD Length = 540 Score = 131 bits (330), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 73/196 (37%), Positives = 110/196 (56%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +NVD+ AA G+ V+ P + AEHAI MM L R+I A +T+ Sbjct: 79 LKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANAQTQ 138 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + G G + GKT G+IG G IG + G M+++AFDP+ + A+E+GVE Sbjct: 139 AGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKVVAFDPFLTPERAVEMGVE 198 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 DL TL +++D I+LH PLT + ++L+ + K GV I+N +RG L+D A +AL Sbjct: 199 KADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRIINCARGGLVDEAALKDAL 258 Query: 248 KNQKIGSLGMDVYENE 263 + + +DV+E E Sbjct: 259 DSGHVAGAALDVFETE 274 >UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MN05_BDEBA Length = 328 Score = 131 bits (329), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 65/205 (31%), Positives = 119/205 (58%), Gaps = 3/205 (1%) Query: 62 EEL--KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 EEL K ++ I +GF+++DL+A ++ G+ V+ P + E+ A+ G++++ Sbjct: 57 EELLKKARQLQLIVTCTSGFDHIDLEATQKWGVTVMHTPTANIESAAQLTWGLVLSCVNN 116 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 I A++ + ++ + +TG + G+ G++G G+IG + + + FGM ++A+DPY Sbjct: 117 IQAAHKMVKAGEWNRDQITGIELAGRNYGIVGLGRIGSRVAELAQAFGMNVVAYDPYQED 176 Query: 180 AALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 E L + + + +DVIS H P T E H+LN + FE + G++++NTSRG++I Sbjct: 177 EVFERLHIPRLSYEEVLKTADVISFHVPKTLETEHMLNRSQFEYIHRGIVLINTSRGSVI 236 Query: 239 DSQAAIEALKNQKIGSLGMDVYENE 263 + EAL+ + S+G+DVYE E Sbjct: 237 NENDLCEALEKGWLRSVGLDVYEKE 261 >UniRef50_Q47W88 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=2 Tax=Alteromonadales RepID=Q47W88_COLP3 Length = 317 Score = 130 bits (328), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 82/261 (31%), Positives = 137/261 (52%), Gaps = 20/261 (7%) Query: 68 GVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRT 127 VK I + G+NNVD++AA+ L + V V Y ++VA++ ++ ++ T Sbjct: 65 NVKLICISATGYNNVDIEAARHLDIAVTNVSGYAGQSVAQYVFAQLLEYYQQTSHHNSNT 124 Query: 128 ------RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 R+ F G + + GKT G+IG G +G A++ I + F M++L P A+ Sbjct: 125 EQGLWSRNDTFCYHGNSISELAGKTLGIIGYGSLGKAVVDIAQAFNMKVL-ISERPQAST 183 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 + E V + E+D+ISLHCP TPE + +NE+ +MKN ++VNT+RGALID Sbjct: 184 IR--AERVSFEQVIEEADIISLHCPQTPETENFINESVLARMKNTAVLVNTARGALIDEP 241 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A ++ALK ++I +DV E ++ ++ ++ +LS N+ T H A+ ++ Sbjct: 242 ALLDALKTKEIAYAILDVLSQE-----PPPADHILLNN---KLS---NLKITAHIAWASS 290 Query: 302 EALTSISQTTLQNLSNLEKGE 322 EA + QN+ +GE Sbjct: 291 EAQQRLIDLLSQNIIAFTQGE 311 >UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Deltaproteobacteria RepID=A8ZXY9_DESOH Length = 532 Score = 130 bits (328), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 93/329 (28%), Positives = 151/329 (45%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V + D + ++ GF ++ L E+ +A+ I + + Sbjct: 1 MTMKVLVSDTIDASGVSRLENESGFAVDVKTGLPPEELKSIIGQYDALIIRSATKVTADI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE +K +A G +NVD+ AA + G+ V+ P + AEH I MMM L R I Sbjct: 61 LEAGAPK-LKAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + R + + L G ++ KT GVIG GKIG + + M ++ FDP + Sbjct: 120 PQGTLSLRSGQWEKKKLQGREVFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIART 179 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +E G EYV L LF+ +D I++H P + LLN+AAFE+MK GVM++N +RG ++D Sbjct: 180 TIENEGFEYVSLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +AL + ++ + +DV+ V + L NV+ T H Sbjct: 240 EADLYDALMSGRVAAAALDVF--------------VTEPPGEHPLLKLDNVIATPHLGAS 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++++ + K T N + Sbjct: 286 TKEAQVNVAEAAAHQIIEFLKNNTVINAV 314 >UniRef50_C0C032 Putative uncharacterized protein n=2 Tax=Firmicutes RepID=C0C032_9CLOT Length = 319 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 80/254 (31%), Positives = 135/254 (53%), Gaps = 16/254 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G +N+D A+E G+KV+ P + AVAE +G+M+ + R + +++ Sbjct: 72 LKVIAKFGVGTDNIDKIKAREYGIKVINAPGQNSNAVAELTVGLMIGVLRGLIPLHKKME 131 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + + G+ + GKT G++G G I + L FG ++A D YP A A V Sbjct: 132 NGEWVRR--VGYEIKGKTIGLLGFGAIARLVAEKLMNFGAEVIASDLYPDAELASRCNVT 189 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V + ++SD++S+H P T E +HL ++AAF MK G ++N +RG++ID+ A AL Sbjct: 190 MVSQKEVMTKSDLVSIHIPATGETHHLFDDAAFRMMKKGAYLINCARGSIIDTGALCRAL 249 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K+ +I +D +E E + K ++++ C NV+ T H T EA T++ Sbjct: 250 KDGRIAGAALDAFEAEPLM----KDAEILK---------CGNVICTPHTGAETYEAYTNV 296 Query: 308 SQTTLQNLSNLEKG 321 S T Q + ++ +G Sbjct: 297 SMCTAQGVIDVLEG 310 >UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquificales RepID=B2V7I1_SULSY Length = 529 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 82/268 (30%), Positives = 131/268 (48%), Gaps = 16/268 (5%) Query: 59 PVLEEL--KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 PV +EL + +K I G +NVDL+ A G+ VV P + AE + + + Sbjct: 54 PVTKELLERAEKLKVIGRAGVGVDNVDLEEASRRGILVVNTPGANTIGAAEITMAHLYAV 113 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R++H A+ + + G + GK G+IG G +G + K G +++A+DPY Sbjct: 114 LRKLHLAHDSVKAGEWKRSKFMGEELDGKVVGIIGLGNVGSQVAIRCKAAGAKVIAYDPY 173 Query: 177 -PSAAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 P LGVE +D L L SD+I+LHCPLT E +++ + F+ MK GV +N +R Sbjct: 174 IPKEKGDRLGVEIIDDLHELIKISDIITLHCPLTEETRNMIGKKEFDLMKKGVYFINCAR 233 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D A +A++ KI LG+DV+ E D+ RRL N+ + Sbjct: 234 GGIVDEDALYDAIQEGKIAGLGLDVFSKEP------------PDERIRRLFEFPNISLSP 281 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGE 322 H T E+ +++ Q + KG+ Sbjct: 282 HIGANTYESQDNVAIKIAQYVIAALKGQ 309 >UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RMS7_ACIFE Length = 529 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 77/251 (30%), Positives = 130/251 (51%), Gaps = 16/251 (6%) Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 G +N+D++ A + G+ VV P + + AEH IG+M+ R +A + + + L Sbjct: 77 GVDNIDIEGATKRGIIVVNTPEANVISAAEHTIGLMLASCRNTVKAQKMIESRVWDRKNL 136 Query: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVD-LPTLF 195 G +Y KT G+IG G+IG + + ++ F M+++A+DPY P + LGVE + L L Sbjct: 137 KGVELYHKTLGIIGLGRIGTLVTKRMQAFEMKVIAYDPYIPDSRFKRLGVEKCETLDDLL 196 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 +++DVI++H P T E +++ + ++ K GV +VN +RG L + QA +A+K ++ S+ Sbjct: 197 AKADVITIHTPKTEETINMIGKEELKKCKKGVRLVNCARGGLYNEQAVADAIKEGQVASI 256 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 G+DV L E K L + T H T EA + + Q + Sbjct: 257 GLDV------LVDEPKP--------ISPLIGLEQCVLTPHLGADTVEAQDKVGISIAQEV 302 Query: 316 SNLEKGETCPN 326 N+ G+ PN Sbjct: 303 VNVLNGQMVPN 313 >UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=9 Tax=Thermococcaceae RepID=B6YUM0_THEON Length = 333 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 90/279 (32%), Positives = 146/279 (52%), Gaps = 24/279 (8%) Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R V+E +K +K I+ AG+++VD+ AA E G+ V +V EAVAE A+G+M+ L Sbjct: 56 REVIERAEK--LKVISCHSAGYDHVDVKAATERGIYVTKVSGVLSEAVAEFAVGLMIALL 113 Query: 118 RRIHRAYQRTRDANFSLEGL--TGF----TMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 RRI + R + + +GF T+YGKT G++G G IG A+ R +K G ++ Sbjct: 114 RRIVYTDRFIRAGKWESHRVIWSGFKDIETVYGKTVGILGMGAIGKAIARRVKALGTEVV 173 Query: 172 AFD-PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + E+ +Y+ L + +D++ L P TPE YH++NE + M+ G +V Sbjct: 174 YWSRSRKKDIEEEVNAKYLSLEEVLKSADIVVLALPATPETYHIINEERLKLME-GKYLV 232 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N RG+L+D +A ++ALK K+ DV+E E V + ++F Sbjct: 233 NIGRGSLVDEEALVKALKEGKLKGYATDVFERE----------PVTEHELF---GMEWET 279 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 + T H A L+ EA+ + ++NL + +GE P +LV Sbjct: 280 VLTPHYAGLSREAMEDMGFRAVENLLTVLRGE-VPGDLV 317 >UniRef50_D1YD83 Putative glyoxylate reductase n=3 Tax=Propionibacterium acnes RepID=D1YD83_PROAC Length = 321 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 95/268 (35%), Positives = 140/268 (52%), Gaps = 26/268 (9%) Query: 14 KYLQQVNESF-GFELEFFD-FLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG--V 69 + + VNE G E+ D F+ ++ ++ +A+ ++D P+ E+ G + Sbjct: 10 QLMSVVNEELPGHEVVGGDHFMDRQELSRQIATADAILTSLSD----PLDAEMIGQGKNL 65 Query: 70 KYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR- 128 K I AGFNN+DLDAA++ G+ V P EA A+ A +++ + RR A + R Sbjct: 66 KVIGQCAAGFNNIDLDAARQAGVVVTSTPGVLHEATADLAFTLLLEVTRRTGEAERWVRA 125 Query: 129 ------DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL--AFDPYPSAA 180 D F L G + G T G++G G+IG AM R FGM ++ A AA Sbjct: 126 GRAWRYDHTFML----GAGLQGATLGIVGLGQIGEAMARRGAAFGMNVIYNARHEKDVAA 181 Query: 181 --ALELGVE---YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A+ L + V+L LF+ SDV+SLHCPLT E HL++ A MK +VNT+RG Sbjct: 182 IDAVNLNTQPTRRVELDELFATSDVVSLHCPLTDETRHLVDADALAAMKKTAYLVNTARG 241 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENE 263 A +D A +EALK I +G+DV+E E Sbjct: 242 ACVDEAALVEALKTGAIAGVGLDVFEEE 269 >UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBM0_9FIRM Length = 529 Score = 130 bits (328), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 82/260 (31%), Positives = 130/260 (50%), Gaps = 16/260 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +N+DLD A + G+ VV P + + AEH IG+++ R RA + Sbjct: 68 LKVIGRAGNGVDNIDLDGATKRGIIVVNTPEANIISAAEHTIGLLLASCRNTVRANKMLE 127 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVE 187 + + + L G +Y KT G+IG G+IG + + + F MR++A+DPY P + LGVE Sbjct: 128 EGIWERKDLKGSELYHKTLGIIGLGRIGALVTKRMHAFDMRVIAYDPYIPDSRFQRLGVE 187 Query: 188 YVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 + L L E+DVI++H P T E ++L A +++ K GV +VN +RG L + Q EA Sbjct: 188 KCETLDDLLKEADVITIHTPKTEETVNMLGAAEWKKCKKGVRVVNCARGGLYNEQDLAEA 247 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTS 306 +K + S+G+DV +E + L + T H T EA Sbjct: 248 VKEGIVASVGLDVVVDE--------------PNPISPLIGMPQCVVTPHLGASTFEAQDK 293 Query: 307 ISQTTLQNLSNLEKGETCPN 326 + + + N+ G+ PN Sbjct: 294 VGLAIAEEVINVLGGKMVPN 313 >UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Thermoproteaceae RepID=A8MCX1_CALMQ Length = 317 Score = 130 bits (327), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 81/257 (31%), Positives = 138/257 (53%), Gaps = 6/257 (2%) Query: 8 TKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKH 67 T + D++ + +++E G +++ + E+ K + + + +R V++ + Sbjct: 14 TDKIDERLINKLSE-MGVAVDYKPGIQHEELLKIVENYDILVVRSRTKVTREVID--RGA 70 Query: 68 GVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRT 127 +K IA G +N+D+D A + GL +V P + AE + +M+ ++R +H Sbjct: 71 SLKIIARAGVGLDNIDVDYALKRGLTIVNSPNAATYSAAELTLSLMLIISRNLHLHLIDV 130 Query: 128 RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-SAAALELGV 186 ++ +S G + GKT GV+G G+IG A+ K GMR+LA D S A ELG Sbjct: 131 KNGKWSKGLYHGIELRGKTLGVVGFGRIGRAVANYAKALGMRILATDVVDISRYAEELGA 190 Query: 187 EYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 V L L S SDV++LH L E YH+LN+ + +K+ +IVNTSRG +ID++A + Sbjct: 191 SVVSLTELLSRSDVVTLHVALNKETYHMLNDDRLKLIKDNAIIVNTSRGEVIDTKALLNH 250 Query: 247 LKNQKIGSLGMDVYENE 263 L ++ +G+DV E+E Sbjct: 251 L--DRLWGVGLDVLEHE 265 >UniRef50_C0C1A5 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0C1A5_9CLOT Length = 345 Score = 130 bits (327), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 101/353 (28%), Positives = 169/353 (47%), Gaps = 49/353 (13%) Query: 3 LAVYSTKQYDKKYLQQVNE-----SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 + ++ T +Y+++ L+ + E G+ L E KT + + + DD + Sbjct: 1 MKIFFTAEYNEEELKPLYEVGEVVKDGWALGLPKMPEEELAEKTRDADMIITSY--DDIT 58 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R V+E + +K IA A NVD+ AAKE G+ V+ P + ++ AE IG+M++ Sbjct: 59 RKVIENAEH--LKLIACTRATPVNVDMAAAKERGIPVLYTPGRNSDSTAEMTIGLMLSAA 116 Query: 118 RRIHRAYQRTRDANFS---------LEGLT-----------------GFTMYGKTAGVIG 151 R+I AY+ + ++ EGL G + GKT G++G Sbjct: 117 RKIPMAYKALKGGEYTGDPSSRKETKEGLKADVIWDMKADAPYMVFKGTQLKGKTLGILG 176 Query: 152 TGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVEYV-DLPTLFSESDVISLHCPLTP 209 G IG + RI + FGM+LL FDP+ +E +G++ + L ESD I+ H +TP Sbjct: 177 YGSIGRRVGRIARAFGMQLLIFDPFVGEVDVEEIGIKKAHSVEELMKESDFITCHMKVTP 236 Query: 210 ENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFE 269 E +++ MK +N SRGA++D +A IEALK ++I DVYE+E Sbjct: 237 ETTGIISRERIALMKPTAYFINASRGAILDEEALIEALKEKRIAGAAFDVYESE------ 290 Query: 270 DKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 + +D + ++ NV+ T H A T + L + ++ + ++ KGE Sbjct: 291 ----PIARDHPY--ITELDNVVVTPHIAGATDDVLVNHTKQIVSDIKRFLKGE 337 >UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C430A3 Length = 540 Score = 130 bits (327), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 84/272 (30%), Positives = 136/272 (50%), Gaps = 17/272 (6%) Query: 60 VLEEL--KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V EEL K +K +A G +N+DLDAA + G+ VV P + + AEH M+ +L Sbjct: 68 VTEELLQKMPNLKIVARAGVGVDNIDLDAATKHGVVVVNAPDGNTISTAEHTFAMISSLL 127 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+I +A + ++ + G + GKT G++G G+IG + + + F M LL FDP+ Sbjct: 128 RKIPQANASIKAGEWNRKAFQGSELRGKTLGIVGFGRIGTQIAKRARAFEMSLLVFDPFL 187 Query: 178 SAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + A E +GV L + ++SD+I++H PLT E +L + K GV ++N +RG Sbjct: 188 TKARAEKIGVTPASLDDVLAQSDIITVHTPLTKETKGILGMENIAKTKQGVFLINCARGG 247 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID A L N I +DV+E E+ + D + L NV+ T H Sbjct: 248 IIDESALKHYLANGHIAGAALDVFE-------EEPAQD-------KELLEFDNVIATPHI 293 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 A T EA +++ + + +G+ N + Sbjct: 294 AASTKEAQLNVASQVSEEVIRFLEGQPATNSI 325 >UniRef50_D1PIB3 Glycerate dehydrogenase n=2 Tax=Clostridiales RepID=D1PIB3_9FIRM Length = 316 Score = 130 bits (326), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 81/253 (32%), Positives = 125/253 (49%), Gaps = 14/253 (5%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K+I + G +++ LDAA+ G+ V Y EAVAE +GM ++L+R + QR R Sbjct: 71 LKFIDVAFTGVDHIGLDAARAKGITVSNASGYSNEAVAELVLGMALSLSRNLTAVEQRCR 130 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY 188 D + +GL GF + GKT G++G GKIG + G +LA A A + V Sbjct: 131 DGK-TKDGLVGFELAGKTVGIVGLGKIGSRTAELFHALGCPILAHSRTVHADAPDY-VRQ 188 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V L L ++SD++ LHCPL ++N MK+ +++N +RG ++ + +AL Sbjct: 189 VSLEDLLAQSDLVVLHCPLNDSTRGMINAEKLAMMKSTALLINVARGPVVVAGDLADALD 248 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 I G+DV++ E L D L C N L T H AF T E++T + Sbjct: 249 QGVIAGAGIDVFDKEPPL------------DAGEPLLHCKNCLVTPHVAFATRESMTLRA 296 Query: 309 QTTLQNLSNLEKG 321 + NL+ G Sbjct: 297 EIVFDNLAAWLAG 309 >UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPS0_9BACT Length = 318 Score = 130 bits (326), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 81/264 (30%), Positives = 135/264 (51%), Gaps = 17/264 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 VK ++ G+NNVD++ A G+K+ P EA A+ A G+++ +RR A + R Sbjct: 67 VKVVSNYAVGYNNVDVEEATSRGVKITNTPGVLTEATADIAFGLLVAASRRFTEAERYLR 126 Query: 129 DANFSLEGLT---GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALEL- 184 ++ T G ++GKT G+IG G+IG A+ R GFGM+++ P A + Sbjct: 127 SGKWTCWHPTMLLGREIFGKTLGLIGFGRIGKAVARRASGFGMKVIYHTPSGGPATDQGD 186 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 G +V + +SD +SLHCPL L+ + E+MK ++VNTSRG ++D + Sbjct: 187 GPRWVSFEEILEKSDYLSLHCPLNDRTRGLIGKKELERMKPDAVLVNTSRGPVVDQTSLY 246 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 E+L++ IG+ G+DVY+ E + ED L + NV+ H T EA Sbjct: 247 ESLRDGVIGAAGLDVYD-EEPISLEDP------------LLSLENVVMLPHIGSATREAR 293 Query: 305 TSISQTTLQNLSNLEKGETCPNEL 328 +++ N+ ++ +G+ N + Sbjct: 294 DAMATMAASNMLDVLEGKEPRNPV 317 >UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HSQ7_9FIRM Length = 317 Score = 130 bits (326), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 84/271 (30%), Positives = 134/271 (49%), Gaps = 25/271 (9%) Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 P L+ + KHGV G+N +D+ AA G+ V P + +VAE AIG+M+ + R Sbjct: 69 PTLKIIAKHGV--------GYNTIDVAAAAAYGIPVTITPGANNISVAELAIGLMLAVAR 120 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 I + R +S +TG +YGK G+IG G IG + + FGM+++A+D P Sbjct: 121 HIPQMDGIVRRGGWSR--MTGSELYGKVLGIIGMGSIGCEVAKRAHAFGMKIIAYDIRPR 178 Query: 179 AAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +E GV Y+ + +++D +SLH P PE ++N+ + MK ++NT+RG L Sbjct: 179 QDMIENYGVTYLPMADCLAQADFLSLHAPALPETIGMINKDTLKTMKRTAFLINTARGDL 238 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 I + +ALKN I G+D + +E I+D RL NV+ T H Sbjct: 239 IVEEDLYDALKNGVIAGAGLDTFVHEP-----------IRD---ARLFTLDNVVLTPHAG 284 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+T + + + + G+ N + Sbjct: 285 ATTHEAVTRMGVMAAEEVVRVLSGQPPQNPV 315 >UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desulfuromonadales RepID=A5GES6_GEOUR Length = 541 Score = 129 bits (325), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 72/211 (34%), Positives = 114/211 (54%), Gaps = 8/211 (3%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K +A G +NVD+D A G+ VV P + + AEHA+ ++++ R I +A + Sbjct: 65 LKMVARAGVGIDNVDIDYASSKGVIVVNAPFGNTNSAAEHAMALLLSFCRNITKANASLK 124 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + TG + GKTAGVIG GK+G + LK F +L DPY + A +LGV+ Sbjct: 125 SGEWKRAPFTGVELKGKTAGVIGLGKVGGRVATRLKAFECDVLGCDPYIAVKRAHDLGVK 184 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V ++ D+I+ H PL E +++ E MK+GV+++N +RG +I+ QA + AL Sbjct: 185 LVSHEEIYKNCDIITFHTPLNEETRNMVGEKEIAMMKDGVILINAARGGIINEQALLNAL 244 Query: 248 KNQKIGSLGMDVYENE-------RDLFFEDK 271 K K+ MDV+ E ++L +DK Sbjct: 245 KGGKVFGAAMDVWSEEPPKSETLKELISQDK 275 >UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fragment) n=2 Tax=Coelomata RepID=B7P3M8_IXOSC Length = 473 Score = 129 bits (325), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 130/260 (50%), Gaps = 15/260 (5%) Query: 67 HGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQR 126 +K I G +N+D DAA G+ V+ P + + AE M++TL+R I A Sbjct: 67 QALKVIGRAGTGVDNIDCDAATRQGILVINAPGGNTLSAAELTCAMIVTLSREIPAATMS 126 Query: 127 TRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAAALELG 185 + + + G +YGKT ++G G+IG + ++ FGM+ + FDP P + E G Sbjct: 127 LKAGKWDRKTFMGNELYGKTLAIVGLGRIGKEVALRMQSFGMKTIGFDPIVPKEVSREFG 186 Query: 186 VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 VE + L ++ +D I++H PL P+ L+ +A+ ++ K GV I+N +RG +++ + Sbjct: 187 VESMSLDEIWPLADYITVHTPLIPQTKDLIGKASLQKCKKGVKIINVARGGIVNEDDLLA 246 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 AL++ G G+DV F E+ + +L A V+ T H T EA Sbjct: 247 ALESGHCGGAGLDV-------FLEEPPKNT-------QLIAHPKVVCTPHLGANTKEAQL 292 Query: 306 SISQTTLQNLSNLEKGETCP 325 ++Q + +L +G++ P Sbjct: 293 RVAQEIAEQFVDLSQGKSVP 312 >UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3Y3_SPHTD Length = 316 Score = 129 bits (325), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 84/244 (34%), Positives = 122/244 (50%), Gaps = 17/244 (6%) Query: 79 FNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLT 138 +N+D+DAA E G+ VV P AVAE IG+++ + R I A + + + Sbjct: 79 VDNIDIDAATERGIVVVHSPGARTYAVAEMTIGLILAVLRHIPAADRSVKAGRWERRAFR 138 Query: 139 GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSES 198 G + G T GVIG G+IG + R+ FG + A+ P LE + VD L + S Sbjct: 139 GRQLRGATVGVIGYGRIGREVARLAHAFGATVKAYTQTPRP--LEHA-KQVDFQALLASS 195 Query: 199 DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMD 258 D+I+LH LT L+N A EQM++GV+IVNT+ G LID A +EAL K+ G+D Sbjct: 196 DIITLHATLTSATRQLINREAIEQMRDGVVIVNTASGGLIDEAALLEALDRGKVAGAGLD 255 Query: 259 VYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNL 318 V+ +E R L V+ T T EA ++S+ LQ+L + Sbjct: 256 VFADE--------------PPSLRALVEHPRVVTTPRIGGSTQEADRAVSELALQSLLAV 301 Query: 319 EKGE 322 +GE Sbjct: 302 LRGE 305 >UniRef50_Q2HEY4 Putative uncharacterized protein n=4 Tax=cellular organisms RepID=Q2HEY4_CHAGB Length = 575 Score = 129 bits (325), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 67/125 (53%), Positives = 81/125 (64%), Gaps = 2/125 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFG--FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M LAV+S K YD+ +L N + L F DF LT TA A+G +AVC+FVND S Sbjct: 330 MNLAVFSAKPYDRDFLTLANSTLPTHHTLTFHDFPLTADTAPLASGADAVCVFVNDALSA 389 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 PVL+ L G + I LRCAG+N+VDL A+ LGL V VPAY PEAVAE A ++ TLNR Sbjct: 390 PVLQTLHAGGTRAILLRCAGYNHVDLAEAERLGLAVANVPAYAPEAVAEFAAALLQTLNR 449 Query: 119 RIHRA 123 R HRA Sbjct: 450 RTHRA 454 Score = 103 bits (257), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 49/104 (47%), Positives = 69/104 (66%) Query: 226 GVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLS 285 G M++NTSRG L+ +++ I ALK++ +G L +DVYE E LF++D S ++IQDD RL Sbjct: 456 GPMLINTSRGGLVRTESVIAALKSKHLGGLALDVYEAEAALFYQDHSAEIIQDDELMRLM 515 Query: 286 ACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 NV+ GHQAF T EALT I++ T++NL + C N LV Sbjct: 516 TFPNVVVCGHQAFFTEEALTEIAECTMRNLDDFYNRIPCKNALV 559 >UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organisms RepID=C7H518_9FIRM Length = 320 Score = 129 bits (325), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 83/259 (32%), Positives = 131/259 (50%), Gaps = 19/259 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR---RIHRAYQ 125 +K++ + G +N+DL+A + G+ V VP Y +VA+ +++ + + R +RA + Sbjct: 67 LKWVGIIATGTDNLDLEACRRHGVAVANVPGYSTYSVAQMTFSLLLAICQCAERYNRAVK 126 Query: 126 R---TRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 + D S+ L + GKT GV G G IG RI + FGM +L Sbjct: 127 QGCWQLDIPESIGLLPQMELCGKTYGVYGYGSIGRQSARIARAFGMEVLVCTRTVRPEYA 186 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 GVE+VD TL D++SLHCP TP+ L+N A +MK G +++NT+RGAL+D +A Sbjct: 187 ADGVEFVDYDTLLRRCDILSLHCPATPQTRGLVNAEALAKMKPGAILLNTARGALVDEEA 246 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 AL + ++G G D + E + Q+ R A + + T H A+ T E Sbjct: 247 VAAALHSGQLGFYGADAFVTE----------PLPQESPLR---AEPHAILTPHIAWTTRE 293 Query: 303 ALTSISQTTLQNLSNLEKG 321 AL ++ T +NL +G Sbjct: 294 ALQNLMDITTRNLRTWLEG 312 >UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia magna RepID=C2HJZ3_PEPMA Length = 313 Score = 129 bits (324), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 98/313 (31%), Positives = 150/313 (47%), Gaps = 30/313 (9%) Query: 25 FELEF---FDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNN 81 FE+++ DFL E+ E + +++ +++ K +K IA AGF+N Sbjct: 21 FEVDYHDSLDFLSKEELKTRIKDVEGLVCPLSEKIDSEIIDAAK--NLKIIANYGAGFDN 78 Query: 82 VDLDAAKELGLKVVRVPAY-DPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLT-- 138 VD+D AKE G+ V PA ++ AE G+M+ L R I + D +F EG Sbjct: 79 VDIDYAKEKGIIVTNAPASASTKSTAELTFGLMIDLLRNITKMNSDCYDNSF--EGWKPV 136 Query: 139 ---GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLF 195 G T+ GKT G+IG G+IG ++R K F M ++ ++ G + VDL L Sbjct: 137 YGLGETLEGKTLGIIGLGRIGTEVMRKAKAFDMNVIFYNRSKKEVD---GAKQVDLNYLL 193 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 SDVI+LH + + +HL++ AF +MK ++N SRG +I Q I AL + +I Sbjct: 194 ENSDVITLHTAYSEKLHHLIDAKAFSKMKKSAYLINASRGKVISEQDLINALNDGEIAGC 253 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 +DVYE FE K I +D L N+L H T A + + T N+ Sbjct: 254 ALDVYE------FEPK----ISED----LRNAKNILLAPHLGNATKLARVQMGEFTFDNI 299 Query: 316 SNLEKGETCPNEL 328 + GE N++ Sbjct: 300 MQFKNGEIPKNKV 312 >UniRef50_B2RGZ9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=8 Tax=Bacteroidales RepID=B2RGZ9_PORG3 Length = 319 Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 144/294 (48%), Gaps = 24/294 (8%) Query: 36 EKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVV 95 E+ A+ C+ +C + R +++ K +K IA G+NN+D+ A G+ V Sbjct: 36 EEIAERIVDCDVLCSVFDIPIGRDLID--KGRSLKLIANYAVGYNNIDVTYAASKGIVVT 93 Query: 96 RVPAYDPEAVAEHAIGMMMTLNRRIHRAYQR--TRDANFSLEGLT---GFTMYGKTAGVI 150 P E A+ A+ ++++ RRI + R RD G G +YGKT G+I Sbjct: 94 NTPRAVIEPTADLALALLLSCTRRIAE-WDRLFRRDGEMVERGRLCRLGVNLYGKTLGII 152 Query: 151 GTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE--LGVEYVDLPTLFSESDVISLHCPLT 208 G G IG A+ R K FGM +L + A E G+ + D L +DV+SLH PLT Sbjct: 153 GFGNIGAAVARRCKAFGMNVLYNKRTRLSEAEEKAQGITFADKDDLIRRADVLSLHTPLT 212 Query: 209 PENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFF 268 PE HL+ A MK +++NT+RGA++D +A +EAL+ ++I + G+DV+EN Sbjct: 213 PETKHLIGTAELSMMKPTAILINTARGAVVDERALVEALREKRIAAAGLDVFEN------ 266 Query: 269 EDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 ND+ ++F A NV T H T ++ + N+ G+ Sbjct: 267 ----NDIPSPELF----AMDNVSLTPHVGTQTYDSRVEMVHELCDNVLGFLHGD 312 >UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Thermoanaerobacterales RepID=C6PA05_CLOTS Length = 355 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 84/214 (39%), Positives = 127/214 (59%), Gaps = 5/214 (2%) Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 D + VL+ KK +K I G +N+D++ A++LG+KV P + E+VA+ A MM Sbjct: 94 DKITEDVLKNAKK--LKVITKYGVGLDNIDINYAEKLGIKVTYTPGANKESVADLAFTMM 151 Query: 114 MTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + L+R I + + R+ ++ + G +YGKT G+IGTG IG + + GF M +LA+ Sbjct: 152 LGLSRDIIKLDKIVRNNQWN--KIIGCEIYGKTIGIIGTGSIGKCVAKRATGFDMEILAY 209 Query: 174 DPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 D YP A ++G++YVD TL +SD I+LH PLT E YH ++E MK+ I+NT Sbjct: 210 DKYPDYDFADKIGMKYVDKKTLLEKSDFITLHVPLTDEMYHFIDEEELNMMKDTAYIINT 269 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDL 266 SRG +I+ A ALK++KI +D +E E L Sbjct: 270 SRGGIINENALYSALKSKKIAGAALDAFETEPPL 303 >UniRef50_B8J355 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=B8J355_DESDA Length = 309 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 75/226 (33%), Positives = 124/226 (54%), Gaps = 16/226 (7%) Query: 44 GCEAVCIFVNDD-----GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVP 98 GC+ V + V+ + P L + K+GV G +N+DL+A K+ G+ V R Sbjct: 48 GCQGVILGVDPMSADVLAAAPELRAIAKYGV--------GLDNIDLEACKQRGIAVSRTV 99 Query: 99 AYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVA 158 + AVA++A+ +M+ + R+ +R R+ ++ +T +YGKT G++G G IG Sbjct: 100 GANSNAVADYALTLMLMVARKAGLIDRRCREKDWG--KITSIDLYGKTLGIVGLGAIGRC 157 Query: 159 MLRILKGFGMRLLAFD-PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNE 217 +++ +GFGM++L D + A A GVE D+ + E+D I+LH LT E + ++ Sbjct: 158 VVKRAQGFGMKILGHDIAWDEAWASAEGVERADMDRICREADFITLHTVLTDETRNCIST 217 Query: 218 AAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 MK +I+NT+RG LID A + AL+ +I G+DV+E E Sbjct: 218 GRIAMMKKTAVIINTARGGLIDETALLTALQEGRIYGAGLDVFEQE 263 >UniRef50_UPI0001B416D9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI0001B416D9 Length = 300 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 88/299 (29%), Positives = 150/299 (50%), Gaps = 29/299 (9%) Query: 25 FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDL 84 FE+++ + +++ + + V + ++ V+ KK +K IA G +N+D Sbjct: 23 FEIDYKPKISSQELLEVIKDYDVVVVRSRTKITKDVISNGKK--LKIIARAGIGVDNIDT 80 Query: 85 DAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYG 144 D A+E +KVV P E+V E + MM+ R +++ + TR +F+ L G + G Sbjct: 81 DYAEEKHIKVVYAPGSSTESVVEITLAMMVIGARSLYKGMENTRKNDFT--KLKGMELEG 138 Query: 145 KTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEY------VDLPTLFSES 198 KT G++G G+IG A++ + F M+ +A+DP P VEY V L L +S Sbjct: 139 KTLGILGFGRIGKAIVDASRTFKMKFIAYDPMP--------VEYPEYVKKVSLDELMEQS 190 Query: 199 DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMD 258 DVIS++ + ++ ++LN+ ++K GV+IVNTSR I+ + ++ LKN KI + D Sbjct: 191 DVISINVTMRKDSPYILNDNELSKLKEGVIIVNTSRARAINGKDMLKYLKNGKISAFVSD 250 Query: 259 VYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSN 317 V+ NE +++ + NV+ T H T EA I+ T N+ N Sbjct: 251 VFWNEP-----------AKEEYEMEMLKLDNVMITPHLGAQTKEAQKRIAIMTADNIIN 298 >UniRef50_C6JFM4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Ruminococcus sp. 5_1_39BFAA RepID=C6JFM4_9FIRM Length = 327 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 72/199 (36%), Positives = 110/199 (55%), Gaps = 2/199 (1%) Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 K VK+I G ++VDL AA + G+ V +P + AVAE A+ ++ L RR + Sbjct: 72 KGKVKFIQKYGTGVDSVDLKAAGKNGIPVANIPGANAPAVAEVAMMHILNLGRRFTNCVE 131 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELG 185 R+ + +TG + GK G+ G G++ + R++ GF ++LLA+DP+ A Sbjct: 132 GCREGIWP-STITGNELDGKIVGLAGYGRVAKNLARMISGFSVKLLAYDPFVKEAVPGQD 190 Query: 186 VEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 + +VD L LF SD++SLH P P ++N++ FE+MK +VNT RG +ID I Sbjct: 191 ITFVDTLEELFERSDIVSLHMPFMPSTARIINKSLFERMKPHAYLVNTCRGGVIDEADLI 250 Query: 245 EALKNQKIGSLGMDVYENE 263 EALK K+ G+DV E Sbjct: 251 EALKTGKLAGAGLDVLTEE 269 >UniRef50_B9E2Y3 Putative uncharacterized protein n=2 Tax=Clostridium kluyveri RepID=B9E2Y3_CLOK1 Length = 337 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 90/277 (32%), Positives = 141/277 (50%), Gaps = 21/277 (7%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 ++ ++E L +K I L+ G+NNVD+ AA E + V +P + E VA H IGM++ L Sbjct: 70 TKEIIESLP--NLKIITLQSIGYNNVDISAATENNVCVTNIPGFCTEEVALHTIGMIIDL 127 Query: 117 NRRIHRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R+I + R + L G + + KT G+ G I AM+ +LK G+ +L + P Sbjct: 128 VRKITFLDRLVRKGKWDPLCGYKTYRLTDKTIGLYFFGSIPKAMMPMLKAMGLNVLVYAP 187 Query: 176 YPSAAALE-LGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + LE G E V+ L +SD +SLHCPL HL++E + MK ++NT+ Sbjct: 188 TKTKEYLEEFGAEKVETFDELLIKSDFVSLHCPLMASTTHLISERELKLMKESAYLINTA 247 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG ++D A I+ALK +I + +DV E+E D Q ++F + N + T Sbjct: 248 RGKVVDETALIKALKEGRIKAAAVDVIEDE----------DNEQSELF----SLENTVIT 293 Query: 294 GHQAFLTAEALTSISQTTLQNLS-NLEKGETCPNELV 329 H AF++ ++ + L+ L L K E P LV Sbjct: 294 PHAAFISEDSFYEGRRRALKQLVLRLAKNEK-PESLV 329 >UniRef50_B4D576 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D576_9BACT Length = 328 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 81/252 (32%), Positives = 130/252 (51%), Gaps = 17/252 (6%) Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 GF++VD+ AA+E G+ V VP Y E VA+HAI + + L R++ + + +++ Sbjct: 85 GFDSVDIAAAREHGIAVCNVPDYGTEEVADHAIALALALCRQLFPLDREAKQLGWTIRVE 144 Query: 138 TGFTMYGK-TAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYV-DLPTL 194 + T GV+G G+IG A K G +++ +DPY P+ +G+ V L L Sbjct: 145 PRLRRLRELTFGVVGLGRIGTAAALRAKALGFKVVFYDPYLPNGVDKAVGIVRVRQLDEL 204 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 ++DV+SLHCPLT E HL+ E +K G +VNT+RGA+I A ++AL+ +I Sbjct: 205 LRQADVVSLHCPLTEETRHLIAEREIALLKPGAFVVNTARGAVIKKTAILDALRTGRIAG 264 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 G+DV E+E E+ +A N++ T H AF + E+ + T+ + Sbjct: 265 AGLDVVEDEPLQTAEE--------------AATPNLIVTCHAAFCSVESKLEMRATSARI 310 Query: 315 LSNLEKGETCPN 326 +GE N Sbjct: 311 ALAAVRGEPLEN 322 >UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepID=C2HP35_LACAC Length = 330 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 80/252 (31%), Positives = 126/252 (50%), Gaps = 19/252 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I+ GF+++D+D A+E G+ V P AE A+ M+M RRI R Sbjct: 79 LKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMASARRIRYYDHALR 138 Query: 129 DA---NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-- 183 + N G+T+ GKT G++G G+IG + R K GM+++ + + LE Sbjct: 139 EGVFLNVDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGMKIIYHNRHQLKPELEAE 198 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 L YVD +L SD +SLH P T E YH++++ F MK+ ++N +RG+L+DS Sbjct: 199 LNARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKDTSFLINVARGSLVDSDDL 258 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 + ALK KI +DV+ENE D++ D NV+ T H T +A Sbjct: 259 VAALKEGKIAGAALDVFENE-----PYPKQDLVNMD---------NVIMTPHVGSATHKA 304 Query: 304 LTSISQTTLQNL 315 ++++ N+ Sbjct: 305 RYNLTKEAANNI 316 >UniRef50_Q2S4U0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S4U0_SALRD Length = 321 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 86/296 (29%), Positives = 150/296 (50%), Gaps = 26/296 (8%) Query: 42 ANGCEAVCIFVNDDGSRPVLEEL--KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA 99 A+G + + + D P+ E L + G++ ++ G +N+DL+AA+ + V P Sbjct: 44 ADGADVLLSVLAD----PITEALFEARPGLQMVSQYAVGVDNIDLEAAEAHDVAVTHTPG 99 Query: 100 YDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS---LEGLTGFTMYGKTAGVIGTGKIG 156 +A A+ A +++ R + A + RD F L G + KT G++G G+IG Sbjct: 100 VLTDATADQAWALLLAAARHVPAADRYVRDGRFERWETTHLMGMELARKTIGIVGMGRIG 159 Query: 157 VAMLRILKGFGMRLLAFDPYPSAAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHL 214 A+ R GFGM ++ + + +E + +V L L + SDV+SLHCP E++HL Sbjct: 160 TAVARRALGFGMEVIYHNRTRANPTVERQVSARHVGLGELLTTSDVVSLHCPHNDESHHL 219 Query: 215 LNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSND 274 L+ AAF +MK ++VNT+RG ++D A ++ALK+ +I G+DV+E+E ++ D Sbjct: 220 LDAAAFSKMKASALLVNTARGPVVDEAALVDALKSGEIAGAGLDVFEDEPEVHPGLMEQD 279 Query: 275 VIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG-ETCPNELV 329 V+ H T + ++Q + +++ L G E+ P+ LV Sbjct: 280 --------------RVVLAPHLGSATTDTRMRMAQMCVASITALLDGAESVPHRLV 321 >UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=16 Tax=Bacteria RepID=B0K1J9_THEPX Length = 320 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 90/263 (34%), Positives = 140/263 (53%), Gaps = 19/263 (7%) Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VL KK +K I G +N+D+D A+ +G+K+ P + E+VA+ +M+ L+R Sbjct: 65 VLRNAKK--LKVITKYGVGVDNIDVDEAERMGIKITYTPDANKESVADLVFALMLGLSRE 122 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 I + R N E + G +Y KT G+IGTG IG + + GF M++LA+D YP+ Sbjct: 123 IIKLDNIVR--NNRWEKIIGNEIYKKTIGIIGTGAIGRCVAKRATGFDMKILAYDKYPNY 180 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A +G++YVD L ESD I+LH PLT E YH ++E + MK+ I+NTSRG +I Sbjct: 181 EFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTSRGGII 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 + A ALKN+KI +DV+E I+ + +L N++ T H Sbjct: 241 NENALYNALKNKKIAGAALDVFE--------------IEPPIDSKLLKLDNIILTPHCGA 286 Query: 299 LTAEALTSISQTTLQNLSNLEKG 321 T +A + ++ L ++ +G Sbjct: 287 STKDATDRMGIMAVEGLISVLEG 309 >UniRef50_Q14L30 Hypothetical d-lactate dehydrogenase protein n=1 Tax=Spiroplasma citri RepID=Q14L30_SPICI Length = 229 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 80/275 (29%), Positives = 131/275 (47%), Gaps = 61/275 (22%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +K+ Y ++ ++ + +++NE +G++L P+ Sbjct: 5 IKMVFYDVRKTERPFFEKLNEKYGYDL-------------------------------PL 33 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +EE L A ELG K+ VP Y P AV+E A+ M R + Sbjct: 34 IEEY-------------------LTKAHELGFKMAYVPGYSPNAVSELAVAMGNDFLRNL 74 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGK-----TAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R NF ++ M+ K T G+IGT +IG + G G ++L +D Sbjct: 75 FYMDNNERKTNFKVDDF----MFAKEIRNSTIGIIGTSRIGFEAAKAWHGMGDKVLGYDI 130 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPE-NYHLLNEAAFEQMKNGVMIVNTSR 234 Y + + + + Y DL TL ESD++SLHCP E N++ +N+ QMK G +++N +R Sbjct: 131 YENDSVRTV-LTYTDLNTLLKESDLVSLHCPYIKEQNHYFVNKEFIAQMKPGSVLINAAR 189 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFE 269 G L+DS+A E +K+ + +G+DV ENE D+FF+ Sbjct: 190 GQLMDSEAVYEVVKSNNLKGVGLDVLENEGDVFFK 224 >UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Pantoea sp. At-9b RepID=C8QAG5_9ENTR Length = 317 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 73/206 (35%), Positives = 115/206 (55%), Gaps = 11/206 (5%) Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 P L+ + KHGV G +N++LDA + G+ V VP + AVA+ A +++ R Sbjct: 66 PQLKIVCKHGV--------GVDNINLDATRARGIYVTNVPDANKHAVADFAFALILNSAR 117 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 ++ +A TR ++ + +YGKT G++G G IG + KGF MR++AFD YP Sbjct: 118 QLTQAAVETRAGHWPR--IFATDVYGKTLGIVGLGNIGKQVALRAKGFNMRVIAFDFYPD 175 Query: 179 AA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A E G+E+V + L + SD I+LH PLT E +L + A ++MK ++N SRG + Sbjct: 176 EKFAAEHGIEFVSMDQLTAASDFITLHTPLTNETRNLFDAARIKRMKKSAFLINVSRGGV 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENE 263 ++ Q +AL++ I DV+E E Sbjct: 236 VNEQDLFQALQDNVIAGAAADVFEQE 261 >UniRef50_B7ALT2 Putative uncharacterized protein n=1 Tax=Bacteroides eggerthii DSM 20697 RepID=B7ALT2_9BACE Length = 318 Score = 128 bits (321), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 80/252 (31%), Positives = 134/252 (53%), Gaps = 19/252 (7%) Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH---RAYQRTRDANFS 133 AG++N+D++ A G+ V P E AE A +++ + RRI R + +R Sbjct: 74 AGYDNIDVNYAITKGILVTNSPKPVIEPTAELAFSLLLNVARRISECDRKLRSSRGIEID 133 Query: 134 LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVE--YVDL 191 + G ++YGKT G++G G IG A+ R GMR++ ++ + +E E +V L Sbjct: 134 VMENLGISLYGKTLGIVGMGAIGQALARRASACGMRIIYYNRKRLSQEIENAYEADWVSL 193 Query: 192 PTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQK 251 L + SD ISLH P T E YH+++ F+ MK V+++NT+RG LI+ + I L+ ++ Sbjct: 194 NELLATSDFISLHAPATSETYHMIDIQQFKLMKPSVVLINTARGNLINERVLIHFLQKKR 253 Query: 252 IGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTT 311 I G+DV+ENE ++ ++++Q D NVL + H T + ++ Sbjct: 254 IFGAGLDVFENEPEI-----PSELLQLD---------NVLLSPHNGTGTIDTRVESTRYA 299 Query: 312 LQNLSNLEKGET 323 LQN+ N +G+T Sbjct: 300 LQNIINYFEGKT 311 >UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillales RepID=B1HVJ4_LYSSC Length = 535 Score = 128 bits (321), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 72/208 (34%), Positives = 114/208 (54%), Gaps = 3/208 (1%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V+E K +K I G +N+DL AA E G+ VV P + + AEH I MM +L Sbjct: 64 TREVIEAAKS--LKLIGRAGVGVDNIDLTAATEHGIIVVNAPDGNTNSAAEHTIAMMTSL 121 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R I +A+ ++ + + G + KT GV+G G+IGV + KG M ++A+DP+ Sbjct: 122 ARHIPQAFNTLKNGKWDRKSYVGVELKNKTLGVVGFGRIGVEVAYRAKGQRMNVMAYDPF 181 Query: 177 -PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A ELGV + + +D I++H PL PE +L+N+ F MK+GV I+N +RG Sbjct: 182 LTDERAKELGVTKASVEEICEAADFITVHTPLLPETRNLINKEKFAMMKDGVRIINCARG 241 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENE 263 +I+ +A+ K+ +DV+ +E Sbjct: 242 GIINEDDLYDAIVAGKVAGAALDVFVSE 269 >UniRef50_A3ZW64 Phosphoglycerate dehydrogenase, putative n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZW64_9PLAN Length = 320 Score = 128 bits (321), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 78/241 (32%), Positives = 127/241 (52%), Gaps = 18/241 (7%) Query: 79 FNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLT 138 +++V++ AA E + V R P ++V EH IGM++ + R + ++ R ++ + Sbjct: 76 YDSVNVPAATEQNIAVCRTPGTLHQSVVEHTIGMILAIYRNVISQNKQVRAGDW--DRTA 133 Query: 139 GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTLFSE 197 G YGKT G+IG G IG + + GM+++A+DP P+ E VE V L ++ Sbjct: 134 GPRAYGKTLGIIGYGVIGKEVAKAAVLLGMQVIAYDPIAPAGGPSE--VERVALDEIWRR 191 Query: 198 SDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGM 257 SDV+SLH P TPE ++N + MK+ +++NTSRG L++ A+K K+ + Sbjct: 192 SDVVSLHAPCTPETERIINAQSLALMKDDALLINTSRGGLVNEPELAAAMKGGKLRGAAL 251 Query: 258 DVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSN 317 DV+E E DK N ++ D N+ FT H A L ++L +S QN+ + Sbjct: 252 DVFEQEPI----DKENPLLDVD---------NIYFTAHMAGLDEQSLLDMSTMAAQNILD 298 Query: 318 L 318 L Sbjct: 299 L 299 >UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobacterium thermophilum RepID=Q67TJ9_SYMTH Length = 540 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 84/260 (32%), Positives = 129/260 (49%), Gaps = 17/260 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQR-T 127 +K + G +N+D+ AA E G+ VV VP + + AEHA G+++ + R I +A+ Sbjct: 62 LKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVARNIPQAHHALA 121 Query: 128 RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGV 186 R+ + G ++GKT G+IG G+IG + + FGMR+LA+DPY P + A LGV Sbjct: 122 REGRWDRMSFVGTELHGKTLGIIGLGRIGSEVAVRARAFGMRVLAYDPYVPHSRAEHLGV 181 Query: 187 EYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 V L L E D +++H TPE+ L+ A MK IVN +RG ++D +A Sbjct: 182 TLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTARIVNCARGGMVDEEALYR 241 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 ALK ++ +DV+ E +F NV+ T H + TAEA Sbjct: 242 ALKEGRLAGAALDVFAAE----------PCTDSPLF----GLPNVVVTPHLSASTAEAQD 287 Query: 306 SISQTTLQNLSNLEKGETCP 325 + + Q + +GE P Sbjct: 288 ANGRYIAQYVLRALRGELVP 307 >UniRef50_D2R987 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R987_9PLAN Length = 327 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 81/258 (31%), Positives = 130/258 (50%), Gaps = 16/258 (6%) Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E LK ++ IA G++++D+ A ELG+ V P E+VAEH I M++ ++R I Sbjct: 64 EFLKTTNLRVIARLGVGYDSIDIPGATELGIAVTITPGTLEESVAEHTIAMLLGVSRGIV 123 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 + R +S + M G+T G++G G+IG A++ +KG GMR++A DPY Sbjct: 124 ERDREVRSTVWSRAPMP--RMAGRTFGIVGLGRIGRAVVPRVKGLGMRVMAADPYADPEF 181 Query: 182 L-ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + + +E V L TL +DV+SLH P + ++NE +MK G + +NTSRGAL+D Sbjct: 182 VRKHNIELVPLETLLETADVVSLHSPSNADTADIINERTLSRMKRGAIFINTSRGALVDE 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A AL + + +DV++ E D L C L H L Sbjct: 242 NALANALLSGHLMGAALDVFKVEP--LPADSP-----------LIKCPTALLCTHMGGLD 288 Query: 301 AEALTSISQTTLQNLSNL 318 E++ + + Q +++L Sbjct: 289 HESVEAATNLAAQCITDL 306 >UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevotella RepID=D1W6S1_9BACT Length = 329 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 77/261 (29%), Positives = 132/261 (50%), Gaps = 24/261 (9%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +KYI + GFN++D+ AA+E G+ V +P+Y +VA+ + T+ R+ Q+TR Sbjct: 77 LKYIGVLATGFNHIDVKAAQEHGVTVCNIPSYSTYSVAQMVFASIFTITNRVEHYAQQTR 136 Query: 129 DANFSLEGLTGFTMY--------GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + +S + F + GKT G++G G IG+ + RI + FGM + A+ ++ Sbjct: 137 EGQWSKR--SDFCYWDTPLLELAGKTMGIVGLGNIGMKVARIAREFGMEVYAYTS-KNSV 193 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 L G++ L LFS SD++SLHCPL+ L+ +MK+G +++NT RG L++ Sbjct: 194 DLPSGIQKTTLDGLFSVSDILSLHCPLSERTRELIKADNLRKMKHGAILINTGRGPLVNE 253 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AL++ ++ + G DV +E N +++ N T H A+ T Sbjct: 254 ADVAAALESGQLAAYGADVMCSEPPA----ADNPLLKQP---------NAFITPHIAWAT 300 Query: 301 AEALTSISQTTLQNLSNLEKG 321 EA + + L N+ +G Sbjct: 301 VEARSRLMNIALNNVRCFLEG 321 >UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria RepID=DHGY_METEA Length = 314 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 91/322 (28%), Positives = 151/322 (46%), Gaps = 34/322 (10%) Query: 12 DKKYLQQVNESFGFELEFFDFLLT---EKTAKTANGCEAVCIFVNDDGSRPVLEELKKH- 67 D++ L F F E+ ++ T E+ + G E I P+ + K Sbjct: 9 DRESLDATVREFNFPHEYKEYESTWTPEEIVERLQGAEIAMI-----NKVPMRADTLKQL 63 Query: 68 -GVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH----- 121 +K IA+ G + VD AAK G+ VV + Y V EH +G+M L R I Sbjct: 64 PDLKLIAVAATGTDVVDKAAAKAQGITVVNIRNYAFNTVPEHVVGLMFALRRAIVPYANS 123 Query: 122 -RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 R + F + + G T G+IG G +G ++ + + GM++LAFD +P Sbjct: 124 VRRGDWNKSKQFCYFDYPIYDIAGSTLGIIGYGALGKSIAKRAEALGMKVLAFDVFPQDG 183 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 VDL T+ ++SDVI+LH PLTP+ +++ ++MK +++NT+RG L+D Sbjct: 184 -------LVDLETILTQSDVITLHVPLTPDTKNMIGAEQLKKMKRSAILINTARGGLVDE 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A ++ALK+ IG G DV E K +++ D + N++ T H A+ + Sbjct: 237 AALLQALKDGTIGGAGFDVVAQE-----PPKDGNILCD------ADLPNLIVTPHVAWAS 285 Query: 301 AEALTSISQTTLQNLSNLEKGE 322 EA+ ++ + N+ G+ Sbjct: 286 KEAMQILADQLVDNVEAFVAGK 307 >UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=1 Tax=Chironex fleckeri RepID=D1FX73_CHIFL Length = 520 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 73/247 (29%), Positives = 121/247 (48%), Gaps = 13/247 (5%) Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 G +N+DL AA G+ V+ P + + AEH MM +L R I + Y ++ + Sbjct: 79 GVDNIDLKAATNNGVFVMNTPGGNTMSAAEHTCAMMFSLARHIPQGYMSMQEGKWERSKF 138 Query: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAAALELGVEYVDLPTLFS 196 G + GKT G+IG G+IG + ++ MR + +DP P AA E GVE+++L ++ Sbjct: 139 MGCELKGKTLGIIGLGRIGKEVALRMQACEMRTVGYDPIVPKEAAAEFGVEFMELEEMWP 198 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 D I++H PL P+ L+N F++ K + ++N +RG +ID ++AL K G Sbjct: 199 IVDFITVHTPLIPQTKGLVNAKTFDKCKKTIRVINVARGGIIDESDLLDALNAGKCAGAG 258 Query: 257 MDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLS 316 +DV+ +E V L V+ T H TAEA +++ + + Sbjct: 259 LDVFSSEP------------PSGVVSELVKHPRVVCTPHLGASTAEAQVRVAKEIAEQIV 306 Query: 317 NLEKGET 323 + G+T Sbjct: 307 DACNGKT 313 >UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WAJ0_FUSMR Length = 313 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 93/307 (30%), Positives = 152/307 (49%), Gaps = 31/307 (10%) Query: 26 ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLD 85 E+E +D E + + E V I +R +E L K +KYI + AG+N +D++ Sbjct: 26 EVEIYDRTPEELVYERSKDAE-VIITNKVPFNRERVERLPK--LKYIGITAAGYNIIDIE 82 Query: 86 AAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL-------T 138 A KE + V P Y + VA+ ++ + + + +D +S E L Sbjct: 83 AVKEKNIIVTNTPNYGSKVVAQMVFAHLLEITNNVGLHSKSVKDGEWS-EKLDFCYWKKP 141 Query: 139 GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVE-YVDLPTLFSE 197 ++ GKT G++G G IG + +I FGM++L +D L ++ V L + Sbjct: 142 IISLEGKTIGILGYGNIGKEVEKIALVFGMKILIYD------RKNLNIDNQVTLEEILKR 195 Query: 198 SDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGM 257 SDVISLH PLT E Y L+N+ ++MK V+++NTSRG L+D +EA+K+ KI +G Sbjct: 196 SDVISLHLPLTEETYRLVNKETIKKMKKDVILINTSRGPLVDETDLLEAIKSGKIYGVGF 255 Query: 258 DVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSN 317 DV +NE K ++++++D + T H A+ EA +I + +NL N Sbjct: 256 DVLKNEP----PQKDSELLKND---------RINITPHIAWAAIEARQNIMKIAEENLKN 302 Query: 318 LEKGETC 324 G+ Sbjct: 303 YLNGKVI 309 >UniRef50_A1ZGW5 D-3-phosphoglycerate dehydrogenase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZGW5_9SPHI Length = 322 Score = 127 bits (320), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 83/257 (32%), Positives = 134/257 (52%), Gaps = 17/257 (6%) Query: 56 GSRPVLEELK----KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIG 111 G+ P+ E+ + G++ I G +N+D + A+ + V +P Y E VAE+AI Sbjct: 55 GAAPIGREIMDAGLQKGLRGIVKAGTGLDNIDCEYARCQQILVENIPDYVHETVAEYAIN 114 Query: 112 MMMTLNRRIHRAYQRTRDANF--SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGM 168 +M++L R+ Q R + G + GKT G++G G+I ++ RI GF M Sbjct: 115 LMLSLARKSWPVQQTMRQKGWFDITPASLGTELNGKTIGLVGFGRIARSVARIAHFGFQM 174 Query: 169 RLLAFDPYPSAAALEL-GVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNG 226 ++A+DPY SA +EL V+ + L + DV+SLH L + +L+ E MK+ Sbjct: 175 SVIAYDPYVSAEEMELCAVQKAEQLEDILPHCDVVSLHTSLNNDTRNLIGEKQLAMMKSS 234 Query: 227 VMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSA 286 +++N +RG +ID A + AL QKIG + +DVY E DV + ++ + Sbjct: 235 ALLINVARGGIIDETALLIALSTQKIGGVALDVYSQE--------PLDVNTHPIISQMIS 286 Query: 287 CHNVLFTGHQAFLTAEA 303 +NVL + H A+ TAEA Sbjct: 287 LNNVLLSPHIAWYTAEA 303 >UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacillaceae RepID=A6CKS4_9BACI Length = 322 Score = 127 bits (320), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 87/272 (31%), Positives = 139/272 (51%), Gaps = 24/272 (8%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 SR V+E+ K +K IA G +N+DL+AA + G+ V P + AVAEH + ++++ Sbjct: 55 SRVVIEKASK--LKVIARHGIGVDNIDLEAASDRGILVTNAPFANVNAVAEHVLTLILSG 112 Query: 117 NRRIHRAYQRTRDANFSLEGLT-GFTMYGKTAGVIGTGKIG-VAMLRILKGFGMRLLAFD 174 +R++ + R+ +F + G + GKT GV+G G IG + + G GM +L +D Sbjct: 113 SRQLIQVDSALRNGDFEVRNRKFGIELKGKTLGVVGFGNIGQLVAEKCHYGLGMDVLVYD 172 Query: 175 PYPSAAALELGVEYVDLPTLFSE----SDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 PY + YV L SE SD++++H P P +HL+NE A +QMK ++V Sbjct: 173 PYVREENVS---SYVQLNQSLSEVLASSDIVTIHVPYLPSTHHLINEEALQQMKKDAILV 229 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RG +ID A +AL + +I +D +E E V L NV Sbjct: 230 NAARGGIIDEIALEKALGSGEIRGACLDCFETE-------------PPAVDHSLWNLENV 276 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 + T H A T EA+ ++ T +++ + KGE Sbjct: 277 IVTPHLAAHTEEAMIEMAVTPAKDIIAIMKGE 308 >UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Archaea RepID=A9A1H5_NITMS Length = 310 Score = 127 bits (320), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 78/259 (30%), Positives = 125/259 (48%), Gaps = 16/259 (6%) Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K K IA G +NVD +AAK ++V+ AVAE +G+M++L R+ R Sbjct: 64 KADNCKIIARVGVGLDNVDQEAAKAKNIRVINAVEGAMNAVAELVLGLMLSLARQTARGD 123 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD--PYPSAAAL 182 + R+ + + L G + GK G++G G IG + R+ + M ++ +D P + Sbjct: 124 RGIRNEQWLKKELKGTELAGKYLGIVGLGNIGKRLGRLARALNMNIIGYDVVPIDEEFSK 183 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E+G+ DL TL +D +S+H PL YHLL+ MK I+NTSRG ++D A Sbjct: 184 EVGLMKADLNTLLQSADYVSIHVPLLDSTYHLLDAQKMSTMKKTAKIINTSRGGVVDEDA 243 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +ALKN +G +DV+E E + +L+ NV+ T H T E Sbjct: 244 LYDALKNGTLGGAALDVFEKE--------------PAIGTKLAELDNVILTPHIGAQTKE 289 Query: 303 ALTSISQTTLQNLSNLEKG 321 A + + + + + +G Sbjct: 290 AQSLAANVIAEKIVQILRG 308 >UniRef50_A8RA71 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RA71_9FIRM Length = 322 Score = 127 bits (319), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 93/331 (28%), Positives = 165/331 (49%), Gaps = 29/331 (8%) Query: 1 MKLAVYSTK--QYDKKYLQQVNESFGFEL---EFFDFLLTEKTAKTANGCEAVCIFVNDD 55 MK+ + S ++D K ++ ES G+++ + + + + G +A+ I +D Sbjct: 1 MKVLITSNSFGKFDPK-PKKFMESLGWQVVGNRYHHIMNEAEMMEEVVGVDAI-ILGSDT 58 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 S+ VLE K +K I+ G +N+DL AK+ ++V + EAVA++A+G+M+ Sbjct: 59 VSKKVLE--KADQLKIISRYGVGIDNIDLMEAKKRNIEVTVTKNCNTEAVADYAVGLMLA 116 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R I + + E TG + KT GVIG G IG +++ LKGF L +D Sbjct: 117 TIRHISNVDANLKQGEWKKE--TGLDLCHKTIGVIGLGAIGRQVIKRLKGFDCHFLGYDK 174 Query: 176 Y-PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 Y A E +E ++ +F ++D+I+LH P P+ L+ + M +I+NT+R Sbjct: 175 YLDKAYCKENNIEVLEPREIFKKADIITLHAPGNPDGTPLIGKEEIGLMNKNTVIINTAR 234 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 +L+D +A +EAL+N +I G DV++ E + + A NV+ + Sbjct: 235 ASLVDEEALLEALENNEIYGYGTDVFDGE--------------PHINEKFQALDNVVLSP 280 Query: 295 HQAFLTAEALTSISQTTLQNLS---NLEKGE 322 H A ++ EA+ ++ + ++ +EKGE Sbjct: 281 HTAAVSVEAINKMTSCAVDHILEFFGIEKGE 311 >UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pyrobaculum aerophilum RepID=Q8ZXX8_PYRAE Length = 323 Score = 127 bits (318), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 84/278 (30%), Positives = 139/278 (50%), Gaps = 18/278 (6%) Query: 41 TANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAY 100 A CEA+ IF+ D + VL+ +K +K ++ G +++D++ AK G+ V P Sbjct: 48 AARRCEALVIFIGDVIDKEVLDAGEK--LKIVSTASVGVDHIDVEYAKRKGVVVAHTPYV 105 Query: 101 DPEAVAEHAIGMMMTLNRRIHRAYQ--RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVA 158 +AVA+ A+G+++ + R+I + R+ A+ L G + GK AG++G G IGVA Sbjct: 106 LVDAVADLAVGLLIAVTRKIALGDRLIRSGAADAVWGSLMGVNLRGKRAGIVGLGNIGVA 165 Query: 159 MLRILKGFGMRLLAFDPYPSAAA-LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNE 217 + R LK F + + + LG+EY++L +L S SD I L LTPE N Sbjct: 166 IARRLKAFDIEVAYWSRRRKPEVEFALGIEYMELDSLLSSSDFIFLTMALTPETRWFFNR 225 Query: 218 AAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQ 277 F ++K G +N +RG L+D+ A IEAL+ + +DV+ DV Sbjct: 226 ERFAKVKRGAYFINVARGGLVDTDALIEALEAGVLAGAALDVF-------------DVEP 272 Query: 278 DDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 +L++ NV+ T H T E +++ +N+ Sbjct: 273 LPARHKLASMDNVVLTPHIGSATVETRRRMAELAAENV 310 >UniRef50_A9CLC8 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Alphaproteobacteria RepID=A9CLC8_AGRT5 Length = 349 Score = 127 bits (318), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 74/207 (35%), Positives = 112/207 (54%), Gaps = 10/207 (4%) Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 P L L KHGV G +N+D+DAA + VV + +VAEHAI ++ + + Sbjct: 87 PSLRVLSKHGV--------GVDNIDVDAASRREIPVVVAAGANALSVAEHAITLLFAVVK 138 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 RI R + G +G + G G++G G I +GFG+++ A+DP+ Sbjct: 139 RIVPLDSGIRAGRWEKAGYSGKELAGMIIGLVGFGAIARQTAVFARGFGLKVQAYDPFTD 198 Query: 179 AAA-LELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A +E GV V D+ L S SD++SLHCPLTP+ +LL++ MK G I+NT+RG Sbjct: 199 ETAFVEAGVHRVADVDDLISSSDILSLHCPLTPDTRNLLDDRRLGMMKPGSFIINTARGG 258 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENE 263 LID A + A+++ I G+D ++ E Sbjct: 259 LIDEDALLRAVESGHIAGAGLDTFQIE 285 >UniRef50_Q2YBY5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Nitrosomonadaceae RepID=Q2YBY5_NITMU Length = 315 Score = 126 bits (317), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 76/243 (31%), Positives = 125/243 (51%), Gaps = 19/243 (7%) Query: 75 RC-AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS 133 RC +G ++VDL AAK G+KV+ P +AVAE ++ ++M R+I + ++ R + Sbjct: 77 RCGSGLDSVDLGAAKRHGIKVLNTPEAPAQAVAELSLALIMAALRKICQTDKQVRAGQWP 136 Query: 134 LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALEL-GVEYVDLP 192 G + + G++G G++G + R+ + F +++A D Y + GV+ V Sbjct: 137 RA--QGGLLAAQKVGIVGLGRVGSRVARLCRAFEAQVVAHDTYVKEMPPGMEGVKLVPFE 194 Query: 193 TLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKI 252 TL +E+D+ISLH + +HLLNE F +MK G +++NT+RG LID A +AL + ++ Sbjct: 195 TLIAEADIISLHLTYDADTHHLLNEKTFARMKPGAIVINTARGGLIDEAALADALNSGQL 254 Query: 253 GSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTL 312 G MDV+E Q+ L C N + T H L E+ + Sbjct: 255 GGAAMDVFE---------------QEPYHGPLLQCDNAILTSHIGSLAKESRQRMELEAA 299 Query: 313 QNL 315 +NL Sbjct: 300 ENL 302 >UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n=2 Tax=Verrucomicrobia RepID=B3DVF6_METI4 Length = 531 Score = 126 bits (317), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 85/249 (34%), Positives = 128/249 (51%), Gaps = 17/249 (6%) Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +R V+E KK +K I G +NVD+DAA E G+ V+ P + A AEH +++ L Sbjct: 59 TRKVIEAGKK--LKVIGRAGVGIDNVDVDAATEKGIVVMNTPGGNTIATAEHTFSLLLAL 116 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R + +A+ + + + G +YGK G+IG G++G+ + + FGM++ FDPY Sbjct: 117 ARNVAQAHASMQLGEWKRKNFEGIELYGKILGIIGLGRVGMEVAKRALAFGMKVKCFDPY 176 Query: 177 PSAAALE-LGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 S ++ L VE V+ L LF + D +SLH PLT E ++N+ ++ K G+ I+N +R Sbjct: 177 LSPTKVKNLQVELVNSLDELFQDIDFLSLHVPLTQETEGIINKDNLKKCKRGIRIINCAR 236 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G LI E LK+ + +DVYE E D R L NV+ T Sbjct: 237 GGLIRIADLEELLKSGWVAGAALDVYEPEPPP----------ADFPLRGLP---NVVLTP 283 Query: 295 HQAFLTAEA 303 H A T EA Sbjct: 284 HLAASTIEA 292 >UniRef50_B1HNB2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Firmicutes RepID=B1HNB2_LYSSC Length = 319 Score = 126 bits (317), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 88/296 (29%), Positives = 149/296 (50%), Gaps = 23/296 (7%) Query: 24 GFELEFFDFLLTEKT--AKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNN 81 G E +++ T+ AK + G + + I N+ V+++ +K I + G ++ Sbjct: 27 GHEFVYYNKKTTDSAELAKRSEGADVIMI-ANNPYPTEVIDQ--NANLKLINVAFTGVDH 83 Query: 82 VDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFT 141 V + A+ + V Y +AVAE IG+++ + RRI + + +F G Sbjct: 84 VGIGQARNQDVMVCNAAGYANQAVAELTIGLVLDVYRRISQGNKEIHADHFP-GAFQGSE 142 Query: 142 MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY---PSAAALELGVEYVDLPTLFSES 198 + GKT G+IGTGKIG+ R+ K FG +++A D P A AL G+EY++L L ++S Sbjct: 143 IKGKTVGLIGTGKIGMMTARLFKAFGAKIVASDQSRRNPEAEAL--GIEYMELDELLAQS 200 Query: 199 DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMD 258 D++SLH PL L+++ E MK +++N +RG ++D+ A +AL +I G+D Sbjct: 201 DIVSLHIPLLSSTKGLISKEKLELMKESAILINCARGPIVDNDALADALNEGRIAGAGID 260 Query: 259 VYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 V++ E + + K L NV+ T H FLT EA+ ++ N Sbjct: 261 VFDMEPPIPGDYK------------LLQAKNVILTPHVGFLTNEAMELRAKIAFDN 304 >UniRef50_UPI0001B59B44 putative D-3-phosphoglycerate dehydrogenase (PGDH) n=2 Tax=Mycobacterium avium complex (MAC) RepID=UPI0001B59B44 Length = 359 Score = 126 bits (316), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 83/254 (32%), Positives = 121/254 (47%), Gaps = 15/254 (5%) Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE- 135 AG++ +D+DA G+ V EAVAEHA+G M+ L ++I + + R Sbjct: 90 AGYDVIDVDACTRAGIAVCNNSGPGAEAVAEHALGFMLDLAKKITVSDRALRSGPLRDRL 149 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTL 194 L G ++GKT GV+G G IG ++ + FGM +L FDPY A GV+ V L L Sbjct: 150 ALRGTQLFGKTLGVVGLGAIGGRLVELCAPFGMEVLVFDPYLDETTARSRGVQQVTLAEL 209 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 SD + + CPLT E L+ F MK + T+RG + D A ++AL + I Sbjct: 210 VERSDFVQVTCPLTSETRGLIGRTQFAAMKPTAFFITTARGPVHDEAALLDALVSGGIAG 269 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 G+DV+ E + N ++Q D NV+ T H A +T EA I+ T Sbjct: 270 AGLDVFHEEP----PRQDNPLLQLD---------NVVATPHTAGITVEAARDIAVATATQ 316 Query: 315 LSNLEKGETCPNEL 328 + +G P L Sbjct: 317 WQTIFEGRMPPRLL 330 >UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WI96_EGGLE Length = 526 Score = 126 bits (316), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 89/307 (28%), Positives = 149/307 (48%), Gaps = 18/307 (5%) Query: 24 GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVD 83 G E++ + E+ +T G +A+ + + V+E + ++ I G +NVD Sbjct: 23 GCEVDVKLKMTPEELIETVPGYDALIVRSATKVTAEVVEAADR--LRIIGRAGVGVDNVD 80 Query: 84 LDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMY 143 ++AA E G+ V P + + AEHAIG+M+ R++ +A + + TG +Y Sbjct: 81 VEAATEHGIIVCNAPTSNIVSAAEHAIGLMLACARKVPQANASMHEGVWERGKYTGVELY 140 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE-YVDLPTLFSESDVI 201 KT + G G+IG + + FGM+L+ +DPY S A +LGV Y D+ L +D I Sbjct: 141 EKTLAIFGLGRIGGLVAERARAFGMKLIGYDPYCSPERAEQLGVTLYDDVDALVPLADFI 200 Query: 202 SLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYE 261 ++H P T E + + +MK+GV++VN +RG + D ++ + L KIG++G+DV+E Sbjct: 201 TVHLPKTKETIGMFGPDQYARMKDGVILVNAARGGIFDEKSLADFLAAGKIGAVGIDVHE 260 Query: 262 NERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 +E D R N + T H A T EA T + ++ +G Sbjct: 261 SEP-----------CTDSPLREFD---NAILTPHIAASTQEAQLRAGVQTAEYVAAGLEG 306 Query: 322 ETCPNEL 328 P L Sbjct: 307 SIVPTAL 313 >UniRef50_C8Q2E6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Pantoea sp. At-9b RepID=C8Q2E6_9ENTR Length = 313 Score = 126 bits (316), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 80/258 (31%), Positives = 127/258 (49%), Gaps = 19/258 (7%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++YI + G++ +DL + +E G+ V VP Y +VAE I + L R + TR Sbjct: 63 LRYICVAATGYDCIDLASCRERGVVVSNVPGYSTRSVAEGVIAFLFALRRHLVDYVNSTR 122 Query: 129 DA-----NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE 183 A +F + +YG T G+IG G IG A+ + + GM++L D A E Sbjct: 123 SAWPAAKHFCVHRQPIQDIYGATLGIIGRGDIGRAVGEMAQALGMKVLYAD---RQGADE 179 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 + Y + ++SDV++LHCPLTPE L+N AA QMK ++NT+RGALI+ Sbjct: 180 VRPGYTPFEQVLAQSDVLTLHCPLTPETKQLINLAALAQMKPSAWLINTARGALINESEL 239 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 AL+ I +DV +E + ++Q DV N+L T H A+ + + Sbjct: 240 AHALRQGVIAGAALDVLSSEP----PAPDHPLLQADV-------PNLLLTPHVAWASQQG 288 Query: 304 LTSISQTTLQNLSNLEKG 321 + ++ + NL +G Sbjct: 289 VANLLRGIESNLEAFWQG 306 >UniRef50_B0TV60 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=21 Tax=cellular organisms RepID=B0TV60_SHEHH Length = 317 Score = 126 bits (316), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 97/306 (31%), Positives = 151/306 (49%), Gaps = 30/306 (9%) Query: 29 FFDFLLTEKTAKT---ANGCEAVCIFVNDDG-SRPVLEELKKHGVKYIALRCAGFNNVDL 84 F +F +++A + A +A IF N L++L K +KYI + G N VDL Sbjct: 24 FGEFTCYDRSAPSEVVARSLDAEIIFTNKTQLDETTLKQLPK--LKYIGILATGTNVVDL 81 Query: 85 DAAKELGLKVVRVPAYDPEAVAE-------HAIGMMMTLNRRIHRA-YQRTRDANFSLEG 136 AAK LG+ V VP Y P+AVA+ HA + + + R + ++D F+L Sbjct: 82 IAAKALGIVVTNVPGYGPDAVAQMVFAHILHATQQVALHSDAVKRGQWSESKDFCFTLMP 141 Query: 137 LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFS 196 L ++ GKT G++G G IG A+ +I FGM+++ P E +V+ TLF Sbjct: 142 LQ--SLKGKTLGLVGFGDIGKAVAQIALAFGMKVIVNTRNPQVKLPE-NCHWVEQATLFK 198 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 ++D++SLHCPLT +L+N MK +++NT+RG LID A AL+ + G Sbjct: 199 QADIVSLHCPLTAATENLVNPQVLSMMKPSAILINTARGGLIDEAALAAALEQGLLAFAG 258 Query: 257 MDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLS 316 +DV L E S D L + N+ + H A+ T EA ++ + NL+ Sbjct: 259 VDV------LSTEPPSAD-------NPLLSAKNISISPHNAWATIEARQNLLDIAIDNLT 305 Query: 317 NLEKGE 322 +G+ Sbjct: 306 RFSQGQ 311 >UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWU5_9CLOT Length = 321 Score = 126 bits (316), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 73/207 (35%), Positives = 116/207 (56%), Gaps = 11/207 (5%) Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 P L+ + + GV G+NN+DL+AAK G+KV + ++VAE+ I +++ R Sbjct: 70 PNLKAIGRFGV--------GYNNIDLEAAKRHGVKVSIATGINADSVAENTILLVLASLR 121 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFG-MRLLAFDPYP 177 + R + + TG + K G++G G I + +++K FG R++A+D YP Sbjct: 122 DLVNLDNAVRRGEWVRDS-TGRIIRNKVYGLVGFGAIARYVAKLVKAFGPARIIAYDKYP 180 Query: 178 S-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + A +LGVE VD T+ ESD+IS+H P TPE Y + E F+ MK+ + VN +RG+ Sbjct: 181 NYEEAEKLGVEIVDFDTVVKESDIISVHVPATPETYKMFGEKEFKAMKDSAVFVNVARGS 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENE 263 ++D A +ALK + I DV+E E Sbjct: 241 VVDEAAMYKALKEKWIARAATDVFEEE 267 >UniRef50_A8HPR9 Predicted protein (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8HPR9_CHLRE Length = 269 Score = 125 bits (315), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 77/258 (29%), Positives = 131/258 (50%), Gaps = 31/258 (12%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY---- 124 ++ IA AG+NN+D++AAK G+ V P Y+ +VAE A+ M++ L+R++ A Sbjct: 32 LRLIAQPAAGYNNIDVEAAKRRGVPVTIAPGYNSHSVAEVALMMILMLSRKVDEARAVFA 91 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALEL 184 +R R G ++GKT GV+G GKIG + +G GM++L S A LE Sbjct: 92 RRERIGEP-----VGGELHGKTLGVVGMGKIGSCLAEAARGLGMQVLGVTSRSSRAELE- 145 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 L + S V++LHCPL+P L+ A M+ G +++N +RG+++D +A Sbjct: 146 --------ALLAASHVVALHCPLSPATRGLIGRAELALMRPGALLLNCARGSVVDREALW 197 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 EAL++ ++G +G+D + + E D D ++ VL H ++AE Sbjct: 198 EALQSGRLGGVGLDTH------WVEPAPRD---DPLYSH----PRVLALPHLGSISAEVY 244 Query: 305 TSISQTTLQNLSNLEKGE 322 + +N++ +G Sbjct: 245 DRFANILCENITRAREGR 262 >UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actinobacteria (class) RepID=Q1AXS3_RUBXD Length = 527 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 81/256 (31%), Positives = 125/256 (48%), Gaps = 16/256 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K I G +N+D++AA + G+ V P + A AEH +G+M+ + RRI A R Sbjct: 63 LKAIGRAGIGVDNIDIEAATKRGILVANAPESNTVAAAEHTLGLMLAVARRIPAADASLR 122 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVE 187 ++ G + KT G++G G +G + R G GMR+LA+DPY S + + VE Sbjct: 123 RGEWNRAAFKGVEVAEKTLGLVGLGHVGSIVARGALGMGMRVLAYDPYVSEERMRSMNVE 182 Query: 188 YV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEA 246 L +F E+D +SLH P TP+ ++ E +MK ++N +RG ++D A A Sbjct: 183 RAGSLEEIFEEADFVSLHVPRTPQTTGMVGEEELARMKPTAYLINVARGGIVDETALYNA 242 Query: 247 LKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTS 306 LK +I +DV F E+ + D L A NV+ T H TAEA Sbjct: 243 LKQGEIAGAALDV-------FAEEPTTD-------SPLFALPNVVVTPHLGASTAEAQDR 288 Query: 307 ISQTTLQNLSNLEKGE 322 T + ++ +GE Sbjct: 289 AGVTAAEQVAAALRGE 304 >UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BYY9_9CLOT Length = 330 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 81/254 (31%), Positives = 128/254 (50%), Gaps = 16/254 (6%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G +N+D D AKE G+KV+ P + AVAE +G M+ L R I Y+ R Sbjct: 78 LKVIAKFGVGTDNIDCDTAKEYGIKVINAPGQNSNAVAELTVGFMIQLLRNILPLYEGIR 137 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-SAAALELGVE 187 + G + GKT G+ G G + + + L F ++A D +P S A + V Sbjct: 138 QGQWVR--YIGGELKGKTVGLFGFGAVAKLVAKKLSSFETEVIACDLHPDSEYAKKYNVG 195 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 V + SD++S+H P T YHL+++A +MK G ++N +RGA++D++A EAL Sbjct: 196 LVSAEEVVERSDILSVHLPATSATYHLVDKAMISKMKRGACMINCARGAVVDTEALTEAL 255 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K+ + +D +E E + D + L C NV+ T H T EA ++ Sbjct: 256 KSGYLAGAALDAFETE----------PLPADSL---LLTCDNVICTPHTGAETYEAYRNV 302 Query: 308 SQTTLQNLSNLEKG 321 S T Q + ++ +G Sbjct: 303 SLCTAQGILDVLEG 316 >UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Actinomycetales RepID=SERA_MYCBO Length = 528 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 71/196 (36%), Positives = 116/196 (59%), Gaps = 1/196 (0%) Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K +A G +NVD+DAA G+ VV P + + AEHA+ +++ +R+I A R Sbjct: 66 LKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPAADASLR 125 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + + +G ++GKT GV+G G+IG + + + FG ++A+DPY S A A +LG+E Sbjct: 126 EHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIE 185 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + L L + +D IS+H P TPE L+++ A + K GV+IVN +RG L+D A +A+ Sbjct: 186 LLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAI 245 Query: 248 KNQKIGSLGMDVYENE 263 + + G+DV+ E Sbjct: 246 TGGHVRAAGLDVFATE 261 >UniRef50_Q1CG62 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=25 Tax=Yersinia RepID=Q1CG62_YERPN Length = 316 Score = 125 bits (313), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 74/253 (29%), Positives = 127/253 (50%), Gaps = 18/253 (7%) Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 G +N+DL AA++ G+++ VP Y E VA+HA M + L R++ R R + ++ + Sbjct: 75 GVDNIDLSAARKRGMRICNVPDYGIEEVADHAAAMTLALARKLGRYEAGIRSGRWEIDQM 134 Query: 138 TG--FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTL 194 ++ T G+IG G+I A + FG R++ FDPY + A G+E + + Sbjct: 135 VDGVRSLRDTTVGLIGLGRIARAYATRMAVFGCRIIGFDPYVTETEARSAGIEPLPQDKV 194 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 + + ++SLH PLTPE L++ A +M G +++N +RG L++ A IEAL + Sbjct: 195 IASAHILSLHVPLTPETRDLIDTTAIARMPEGAILINCARGGLVNEVALIEALTRGHLSG 254 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 G+DV+E E + D R+ ++L + H AF + ++ + Q + Sbjct: 255 AGLDVFEQE----------PLPADSALRK---APHLLLSPHAAFFSDASVKKLQQLASEE 301 Query: 315 LSNLEKGET--CP 325 +GE CP Sbjct: 302 ALRGLRGEPLRCP 314 >UniRef50_C0FP84 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0FP84_9FIRM Length = 335 Score = 125 bits (313), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 80/250 (32%), Positives = 128/250 (51%), Gaps = 24/250 (9%) Query: 64 LKKH-GVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 L +H +KY+A G+ D + ++ G+ + Y + +AE+A ++M + I Sbjct: 75 LSQHPNLKYVATLGHGWEKFDTEMTRKRGISISNT-IYGSQTIAEYAFALLMDVCHHIGT 133 Query: 123 AYQRTRDANFSL-EGLTGFT--------MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 R + ++S+ E F +Y KT GVIG G IG A ++ +GFGM +LA+ Sbjct: 134 HDTRIKTIDWSVPENHNEFCKSVTRQIELYDKTIGVIGLGAIGFAFAKMAQGFGMHVLAY 193 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + A +E V L L + SD ISLH P TP H++++ +MK+GV+++NT+ Sbjct: 194 SRHKKEGAAYDFIEQVSLDELLARSDFISLHTPHTPATEHMIDQNTIARMKDGVILINTA 253 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RGALID QA +AL + K+ + G+DV +E + L N + T Sbjct: 254 RGALIDEQALADALASGKVLAAGLDVLTDEPPVHGSP-------------LLTAPNTVIT 300 Query: 294 GHQAFLTAEA 303 GH A+LT E+ Sbjct: 301 GHIAWLTRES 310 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P52643 D-lactate dehydrogenase n=152 Tax=Bacteria RepID... 491 e-137 UniRef50_P44501 2-hydroxyacid dehydrogenase homolog n=103 Tax=ce... 452 e-125 UniRef50_Q8Z0N3 D-lactate dehydrogenase n=9 Tax=Bacteria RepID=Q... 434 e-120 UniRef50_A9KHK7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 433 e-120 UniRef50_Q31F74 D-isomer specific 2-hydroxyacid dehydrogenase, N... 427 e-118 UniRef50_Q4K893 D-lactate dehydrogenase n=15 Tax=Gammaproteobact... 419 e-116 UniRef50_P30799 2-hydroxyacid dehydrogenase homolog n=7 Tax=Bact... 419 e-116 UniRef50_B2JFX7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 416 e-115 UniRef50_B6HIS7 Pc21g23650 protein n=11 Tax=cellular organisms R... 415 e-114 UniRef50_D2LI76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 414 e-114 UniRef50_C5K2M9 D-lactate dehydrogenase n=2 Tax=Ajellomyces derm... 412 e-114 UniRef50_B4SP29 D-isomer specific 2-hydroxyacid dehydrogenase NA... 412 e-114 UniRef50_C7QLW6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 412 e-114 UniRef50_Q22CX9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 405 e-111 UniRef50_B5EQZ7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 405 e-111 UniRef50_UPI0001AEC4CE D-lactate dehydrogenase n=1 Tax=Alteromon... 404 e-111 UniRef50_A7FYM9 D-lactate dehydrogenase n=10 Tax=Clostridium Rep... 403 e-111 UniRef50_C0A4H0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 403 e-111 UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archa... 402 e-111 UniRef50_Q9P7Q1 2-hydroxyacid dehydrogenase homolog 2 n=2 Tax=Sc... 400 e-110 UniRef50_B9ZMK9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 396 e-109 UniRef50_B7KQC7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 396 e-109 UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehyd... 393 e-108 UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellu... 391 e-107 UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicy... 388 e-106 UniRef50_C5P2R3 D-lactate dehydrogenase, putative n=5 Tax=cellul... 387 e-106 UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Arch... 385 e-105 UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms ... 381 e-104 UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, N... 380 e-104 UniRef50_A8SQC5 Putative uncharacterized protein n=4 Tax=Clostri... 380 e-104 UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms... 380 e-104 UniRef50_Q54UF7 Putative D-lactate dehydrogenase n=1 Tax=Dictyos... 378 e-103 UniRef50_A8UL50 D-lactate dehydrogenase n=2 Tax=unclassified Fla... 377 e-103 UniRef50_C9KNY1 D-lactate dehydrogenase n=2 Tax=Clostridiales Re... 377 e-103 UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 377 e-103 UniRef50_C8W7M7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 377 e-103 UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 377 e-103 UniRef50_D2QQC4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 374 e-102 UniRef50_Q89388 A53R protein n=3 Tax=Chlorovirus RepID=Q89388_PBCV1 373 e-102 UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 369 e-101 UniRef50_C1DZN2 D-Lactate dehydrogenase n=2 Tax=Micromonas RepID... 368 e-100 UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Lepto... 368 e-100 UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 368 e-100 UniRef50_A5VLZ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 368 e-100 UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms... 367 e-100 UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichop... 366 e-100 UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquif... 366 e-100 UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinu... 366 e-100 UniRef50_A6LTK2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 365 e-100 UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, N... 365 e-99 UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actin... 365 1e-99 UniRef50_C4Z227 D-lactate dehydrogenase n=1 Tax=Eubacterium elig... 365 1e-99 UniRef50_B5HCN2 D-lactate dehydrogenase n=6 Tax=Streptomyces Rep... 365 1e-99 UniRef50_O66939 D-lactate dehydrogenase n=1 Tax=Aquifex aeolicus... 365 1e-99 UniRef50_A4S3N1 Predicted protein n=2 Tax=Ostreococcus RepID=A4S... 364 2e-99 UniRef50_D2W085 Predicted protein n=1 Tax=Naegleria gruberi RepI... 364 2e-99 UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncul... 364 3e-99 UniRef50_C9NGL5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 363 4e-99 UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verru... 363 5e-99 UniRef50_Q0SVM3 D-lactate dehydrogenase n=31 Tax=Bacteria RepID=... 363 5e-99 UniRef50_P17584 D-2-hydroxyisocaproate dehydrogenase n=9 Tax=Lac... 362 7e-99 UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verru... 362 9e-99 UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dicty... 362 1e-98 UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Ta... 362 1e-98 UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntr... 361 2e-98 UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=... 361 2e-98 UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 360 3e-98 UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 T... 360 6e-98 UniRef50_C0GGJ9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 359 8e-98 UniRef50_D1PMF0 D-lactate dehydrogenase n=1 Tax=Subdoligranulum ... 359 1e-97 UniRef50_O83080 D-lactate dehydrogenase n=2 Tax=Treponema pallid... 358 1e-97 UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 358 1e-97 UniRef50_C1DWX6 Glyoxylate reductase (Glycolate reductase) n=6 T... 358 1e-97 UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Eurya... 358 2e-97 UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobac... 358 2e-97 UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyan... 358 2e-97 UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fr... 358 2e-97 UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonel... 357 3e-97 UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Delta... 357 4e-97 UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clost... 356 6e-97 UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomy... 356 7e-97 UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cel... 356 7e-97 UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacil... 356 7e-97 UniRef50_Q59642 D-lactate dehydrogenase n=5 Tax=Lactobacillaceae... 356 8e-97 UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Ther... 355 9e-97 UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 355 9e-97 UniRef50_A0Q8P3 D-isomer specific 2-hydroxyacid dehydrogenase n=... 355 1e-96 UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cell... 355 1e-96 UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bila... 354 2e-96 UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staph... 354 2e-96 UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 353 3e-96 UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 353 3e-96 UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (P... 353 5e-96 UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 353 5e-96 UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 353 6e-96 UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Baci... 353 7e-96 UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina R... 352 7e-96 UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella pal... 352 9e-96 UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halot... 352 9e-96 UniRef50_C3WFC0 D-lactate dehydrogenase n=2 Tax=Bacteria RepID=C... 352 1e-95 UniRef50_B2UXX3 D-lactate dehydrogenase n=2 Tax=Clostridium RepI... 352 1e-95 UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clost... 352 1e-95 UniRef50_B1L1I5 D-lactate dehydrogenase n=16 Tax=Clostridium Rep... 352 1e-95 UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, N... 352 2e-95 UniRef50_B2GCQ6 D-2-hydroxyisocaproate dehydrogenase n=3 Tax=Lac... 351 2e-95 UniRef50_C0QZF2 Lactate dehydrogenase-like dehydrogenase n=2 Tax... 350 3e-95 UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillale... 350 3e-95 UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acido... 350 4e-95 UniRef50_C8P1U4 D-lactate dehydrogenase n=1 Tax=Erysipelothrix r... 350 4e-95 UniRef50_B7S4E4 2-hydroxyacid dehydrogenase n=1 Tax=Phaeodactylu... 350 5e-95 UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehal... 349 6e-95 UniRef50_Q6RK69 D-lactate dehydrogenase n=4 Tax=Lactobacillus Re... 349 6e-95 UniRef50_C3RQ64 D-lactate dehydrogenase n=4 Tax=Bacteria RepID=C... 349 7e-95 UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n... 349 8e-95 UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n... 349 1e-94 UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms ... 348 2e-94 UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (cla... 347 2e-94 UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pl... 347 2e-94 UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 347 3e-94 UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planc... 346 4e-94 UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Baci... 346 4e-94 UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostri... 346 5e-94 UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 346 5e-94 UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister... 346 6e-94 UniRef50_Q11QU3 D-lactate dehydrogenase n=1 Tax=Cytophaga hutchi... 345 1e-93 UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplasti... 344 2e-93 UniRef50_P26297 D-lactate dehydrogenase n=73 Tax=Lactobacillales... 344 2e-93 UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria... 344 2e-93 UniRef50_C8P020 D-lactate dehydrogenase n=1 Tax=Erysipelothrix r... 343 4e-93 UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 T... 343 5e-93 UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate ... 343 5e-93 UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC ... 343 6e-93 UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacilla... 343 7e-93 UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 342 8e-93 UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Fir... 342 9e-93 UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacte... 342 9e-93 UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 342 1e-92 UniRef50_C4F960 Putative uncharacterized protein n=2 Tax=Collins... 341 1e-92 UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID... 341 2e-92 UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, N... 341 2e-92 UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales Re... 341 3e-92 UniRef50_Q036G7 Lactate dehydrogenase related 2-hydroxyacid dehy... 341 3e-92 UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desu... 340 3e-92 UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 340 4e-92 UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostri... 340 5e-92 UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denit... 340 6e-92 UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydro... 340 6e-92 UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Egger... 339 7e-92 UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacte... 339 9e-92 UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 338 1e-91 UniRef50_Q47748 D-specific alpha-keto acid dehydrogenase n=50 Ta... 338 2e-91 UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxy... 337 3e-91 UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepI... 337 4e-91 UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostell... 336 6e-91 UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cell... 336 6e-91 UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NA... 336 7e-91 UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Stap... 336 8e-91 UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brach... 336 9e-91 UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostri... 335 1e-90 UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacte... 335 1e-90 UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase fa... 335 1e-90 UniRef50_C0WS24 D-lactate dehydrogenase n=6 Tax=Lactobacillus Re... 334 3e-90 UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3... 333 5e-90 UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirel... 333 5e-90 UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desul... 333 5e-90 UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clos... 333 8e-90 UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 332 1e-89 UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases... 332 1e-89 UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, N... 332 1e-89 UniRef50_C5NVX3 D-lactate dehydrogenase n=2 Tax=Bacilli RepID=C5... 331 2e-89 UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Ta... 331 2e-89 UniRef50_C9BJM5 D-isomer specific 2-hydroxyacid dehydrogenase n=... 331 2e-89 UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lacto... 331 2e-89 UniRef50_A5VJC4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 331 3e-89 UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0... 331 3e-89 UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 331 3e-89 UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacil... 330 4e-89 UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 330 4e-89 UniRef50_C1P7N1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 330 6e-89 UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax... 330 6e-89 UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostri... 329 7e-89 UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosin... 329 1e-88 UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 328 1e-88 UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniph... 328 2e-88 UniRef50_C2EUZ1 D-lactate dehydrogenase n=4 Tax=Lactobacillus Re... 328 2e-88 UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydro... 328 2e-88 UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostri... 328 2e-88 UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deino... 328 2e-88 UniRef50_B2KDH0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 327 2e-88 UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 327 3e-88 UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group ... 327 3e-88 UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia... 327 4e-88 UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepI... 326 4e-88 UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 326 5e-88 UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organis... 326 9e-88 UniRef50_Q7UQC8 Probable 2-hydroxyacid dehydrogenase n=3 Tax=Bac... 325 1e-87 UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 325 1e-87 UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopire... 325 2e-87 UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerot... 325 2e-87 UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobil... 324 2e-87 UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria ... 323 4e-87 UniRef50_A5IXT8 D lactate dehydrogenase n=4 Tax=Mycoplasma RepID... 323 5e-87 UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, N... 323 5e-87 UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, N... 323 8e-87 UniRef50_Q03UK9 Lactate dehydrogenase n=5 Tax=Leuconostocaceae R... 322 1e-86 UniRef50_A8Z3G0 (R)-2-hydroxyacid dehydrogenase n=67 Tax=Bacilli... 322 1e-86 UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax... 322 1e-86 UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 321 2e-86 UniRef50_B3E5B4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 321 2e-86 UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 321 2e-86 UniRef50_C3XA69 Dehydrogenase n=2 Tax=Oxalobacter formigenes Rep... 321 2e-86 UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 321 2e-86 UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NA... 321 2e-86 UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 321 3e-86 UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetoba... 321 3e-86 UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobact... 320 4e-86 UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NA... 320 4e-86 UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n... 319 7e-86 UniRef50_P63940 D-lactate dehydrogenase n=61 Tax=Bacilli RepID=L... 319 1e-85 UniRef50_C1BVE3 D-lactate dehydrogenase n=1 Tax=Lepeophtheirus s... 319 1e-85 UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 319 1e-85 UniRef50_B9DL13 D-specific D-2-hydroxyacid dehydrogenase n=4 Tax... 318 1e-85 UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=ce... 318 1e-85 UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leu... 318 1e-85 UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Ta... 318 2e-85 UniRef50_B1HNB2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Firmi... 318 2e-85 UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevo... 318 2e-85 UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 318 2e-85 UniRef50_Q9BLF6 D-lactate dehydrogenase n=1 Tax=Octopus vulgaris... 317 3e-85 UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostri... 317 4e-85 UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 317 4e-85 UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 317 4e-85 UniRef50_B4RIC5 D-lactate dehydrogenase n=1 Tax=Phenylobacterium... 316 5e-85 UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 316 6e-85 UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NA... 316 6e-85 UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria R... 316 7e-85 UniRef50_C7TLC2 D-2-hydroxyacid dehydrogenase n=7 Tax=Lactobacil... 316 7e-85 UniRef50_B3SAF7 Putative uncharacterized protein n=1 Tax=Trichop... 316 8e-85 UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces... 316 9e-85 UniRef50_D1PIB3 Glycerate dehydrogenase n=2 Tax=Clostridiales Re... 316 9e-85 UniRef50_Q0ADX2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 316 1e-84 UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerot... 315 1e-84 UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 314 2e-84 UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=... 314 3e-84 UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Ta... 314 3e-84 UniRef50_D1YD83 Putative glyoxylate reductase n=3 Tax=Propioniba... 314 3e-84 UniRef50_Q2S4U0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 313 4e-84 UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Acti... 313 6e-84 Sequences not found previously or not previously below threshold: UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS... 324 3e-87 UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma ... 321 1e-86 >UniRef50_P52643 D-lactate dehydrogenase n=152 Tax=Bacteria RepID=LDHD_ECOLI Length = 329 Score = 491 bits (1264), Expect = e-137, Method: Composition-based stats. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV Sbjct: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI Sbjct: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA Sbjct: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS Sbjct: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT Sbjct: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 AEALTSISQTTLQNLSNLEKGETCPNELV Sbjct: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 >UniRef50_P44501 2-hydroxyacid dehydrogenase homolog n=103 Tax=cellular organisms RepID=DDH_HAEIN Length = 331 Score = 452 bits (1163), Expect = e-125, Method: Composition-based stats. Identities = 231/329 (70%), Positives = 280/329 (85%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A+YSTK YD+KY++ +N + F+LEFFDF+L E T + A CE VCIFVND+GSR V Sbjct: 1 MKIAIYSTKSYDRKYIELINAKYNFDLEFFDFMLNESTVRLAEHCEVVCIFVNDNGSRKV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L GVK +ALRCAGFNNVDL AA+ELG++VVRVPAY PEAVAEH IG+MMTLNRRI Sbjct: 61 LEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTLNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAYQRTR+ANFSLEGL GF MYG+T GVIGTGKIG+A++RILKGFGM +LA+DP+ + Sbjct: 121 HRAYQRTREANFSLEGLIGFNMYGRTVGVIGTGKIGIAVMRILKGFGMNILAYDPFKNPV 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ELG +YV+L L+++S VI+LHCP TPENYHLLN AF +MK+GVMIVNTSRG+LID+ Sbjct: 181 VEELGGQYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGVMIVNTSRGSLIDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QAAI+ALK +KIG+LGMDVYENERDLFFEDKSN+VIQDD+FRRLS+CHNVL TGHQAFLT Sbjct: 241 QAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQDDIFRRLSSCHNVLLTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 EALT+I+ TL N+ L+ G+ C N ++ Sbjct: 301 EEALTNIADVTLSNIYKLKSGKVCENIVL 329 >UniRef50_Q8Z0N3 D-lactate dehydrogenase n=9 Tax=Bacteria RepID=Q8Z0N3_ANASP Length = 341 Score = 434 bits (1116), Expect = e-120, Method: Composition-based stats. Identities = 188/328 (57%), Positives = 247/328 (75%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+STK YD+++L+ N EL FF+ L + TA A G AVC+FV+D Sbjct: 1 MKVAVFSTKAYDRQFLEAANAPKHHELAFFEPRLNQDTAILAAGFPAVCVFVHDQVDAAT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G + I LRCAGFNNVDL AA +LG+ VVRVPAY P VAEHA+G++++LNR+I Sbjct: 61 LEILASRGTRLIVLRCAGFNNVDLKAANKLGVTVVRVPAYSPYGVAEHAVGLILSLNRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY R R+ NF+L+GL GF + G+T G+IGTGKIG+ + +I+KGFG RLLA+D Y + Sbjct: 121 HRAYNRVREGNFALDGLLGFNINGRTVGIIGTGKIGLILGQIMKGFGCRLLAYDVYRNPE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG EYV+LP LF+ SD+ISLHCPL P+ +HL+N A EQ+K GVM++NTSRGALI + Sbjct: 181 MESLGGEYVELPELFANSDIISLHCPLMPQTHHLINAEAIEQVKPGVMLINTSRGALIHT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QA IE LK KIGSLG+DVYE E +LFFED S ++IQDD+F+RL+ NVL TGHQAF T Sbjct: 241 QAVIEGLKTGKIGSLGVDVYEQESELFFEDLSGEIIQDDIFQRLTTFPNVLITGHQAFFT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +AL +I++TTL N++++E+G +CPNE+ Sbjct: 301 EDALRNIAETTLNNIADIEQGRSCPNEI 328 >UniRef50_A9KHK7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KHK7_CLOPH Length = 346 Score = 433 bits (1115), Expect = e-120, Method: Composition-based stats. Identities = 170/328 (51%), Positives = 228/328 (69%), Gaps = 5/328 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +K+A + TK YDK++ + N F++++++ L TAK A+GC+AV FVND + Sbjct: 2 IKVACFDTKSYDKEWFDRKNNG-EFQIKYYENKLNADTAKLAHGCQAVIAFVNDSIDKET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +EEL + G+K IA+RCAG+NN+D A + + VVRVP Y P AVAEHA+ +++ LNR+I Sbjct: 61 IEELYQLGIKVIAMRCAGYNNIDFKEAYQK-IAVVRVPGYSPHAVAEHAMALLLCLNRKI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTRD NFSL+GL GF +Y KT GV+GTGKIG + I KGFGMR+LA+D YP + Sbjct: 120 HRAYIRTRDYNFSLKGLIGFDLYKKTIGVVGTGKIGQVFIDICKGFGMRVLAYDLYPDHS 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +EYV L TLFSESDVISLHCPLT E+ H++N + MK +I+NTSRGALIDS Sbjct: 180 K---DIEYVSLETLFSESDVISLHCPLTEESKHMINAETLKLMKQDAVIINTSRGALIDS 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A + ALK ++I G+DVYE E DLFFED S + +DDV L NV+ T HQ FLT Sbjct: 237 EALLVALKEERIAGAGLDVYEEESDLFFEDNSGTIPKDDVLSLLVGLPNVIITSHQGFLT 296 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL++I++TT++NL E+ NE+ Sbjct: 297 NEALSNIAETTIENLRAYFHDESLINEI 324 >UniRef50_Q31F74 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=11 Tax=cellular organisms RepID=Q31F74_THICR Length = 352 Score = 427 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 176/318 (55%), Positives = 235/318 (73%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A +S + DK + + +S E F + L+EKT G EA+C+FVNDD S V Sbjct: 19 MKVAFFSATKTDKNFFETNRQSDSLEFVFLEAHLSEKTVPLVQGVEAICVFVNDDLSEEV 78 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +L +GVK IALRCAGFNNVD++AA++ GL ++RVPAY P AVAEHA+ +MM+LNR+ Sbjct: 79 IRQLASYGVKLIALRCAGFNNVDIEAARQHGLTILRVPAYSPMAVAEHALALMMSLNRKT 138 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +RAY R RD NF+LEGL GF M+ KTAG++GTG+IG+ M RIL G G+ +L +DP+P+ Sbjct: 139 YRAYNRIRDGNFALEGLLGFDMFQKTAGIMGTGRIGLEMTRILTGLGLNVLVYDPFPNQQ 198 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+E G EYV L TL+ +SD+ISLH PL PE +H+++ A QMK GVM++NTSRGAL+D+ Sbjct: 199 AIEYGAEYVSLATLYQQSDIISLHMPLLPETHHIIDADAIAQMKPGVMLINTSRGALMDA 258 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I LK +KIG LG+DVYE E +LFFED S ++IQDD F RL + NVL TGHQAF T Sbjct: 259 DALIAGLKTEKIGYLGIDVYEQEENLFFEDHSEEIIQDDAFERLVSFPNVLITGHQAFFT 318 Query: 301 AEALTSISQTTLQNLSNL 318 EALT+I+QTT++N+ + Sbjct: 319 QEALTNITQTTIENILDY 336 >UniRef50_Q4K893 D-lactate dehydrogenase n=15 Tax=Gammaproteobacteria RepID=Q4K893_PSEF5 Length = 329 Score = 419 bits (1079), Expect = e-116, Method: Composition-based stats. Identities = 166/328 (50%), Positives = 229/328 (69%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ ++S++ YD++ G EL+F L+ TA A E VC F+NDD S PV Sbjct: 1 MRTILFSSQNYDRESFLGAQLPAGIELQFQAARLSLDTAALAERHEVVCAFINDDLSAPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L G + IALR AG+N+VDL AA+ LGL VVRVPAY P AVAEHA+ +++ LNRR+ Sbjct: 61 LEQLAAGGTRLIALRSAGYNHVDLSAAQRLGLDVVRVPAYSPHAVAEHAVALILALNRRL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTR+ +F+L GLTGF + GKT G++GTG+IG RI+ GFG +LLA+DP+P+ A Sbjct: 121 HRAYNRTREGDFTLHGLTGFDLVGKTVGIVGTGQIGATFARIMAGFGCQLLAYDPFPNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG Y+DLP L ++S +ISLHCPLT ++ +L+N+ + M+ G M++NT RG L+D+ Sbjct: 181 VEALGARYLDLPELLAQSQIISLHCPLTEDSRYLINQQSLAHMQPGAMLINTGRGGLVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEALK+ ++G LG+DVYE E LFFED+S+ +QDDV RL NV+ T HQAFLT Sbjct: 241 PALIEALKSGQLGYLGLDVYEEEAQLFFEDRSDLPLQDDVLARLLTFPNVIVTAHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL +I++TTL N+++ G+ N + Sbjct: 301 REALAAIAETTLHNIASWAAGQ-PQNRV 327 >UniRef50_P30799 2-hydroxyacid dehydrogenase homolog n=7 Tax=Bacteria RepID=DDH_ZYMMO Length = 331 Score = 419 bits (1078), Expect = e-116, Method: Composition-based stats. Identities = 166/331 (50%), Positives = 236/331 (71%), Gaps = 2/331 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A++S+K YD +++ NE +G +L F + LT++TA+ A EAVCIFVND+ + V Sbjct: 1 MRVAIFSSKNYDHHSIEKENEHYGHDLVFLNERLTKETAEKAKDAEAVCIFVNDEANAEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G+K +ALRCAG+NNVDLDAAK+L +KVVRVPAY P +VAE+A+GM++TLNR+I Sbjct: 61 LEILAGLGIKLVALRCAGYNNVDLDAAKKLNIKVVRVPAYSPYSVAEYAVGMLLTLNRQI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 R +R R+ NFSLEGL G ++ KT G+IG G IG I+ GFG ++A+ P+P Sbjct: 121 SRGLKRVRENNFSLEGLIGLDVHDKTVGIIGVGHIGSVFAHIMTHGFGANVIAYKPHPDP 180 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A ++G + L + SD+ISLHCPLTPEN+H++NE + K G +VNTSRG L+ Sbjct: 181 ELAKKVGFRFTSLDEVIETSDIISLHCPLTPENHHMINEETLARAKKGFYLVNTSRGGLV 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D++A I++LK + +G DVYE E LFFE+ ++D+I+DD+ RL A NV+FTGHQAF Sbjct: 241 DTKAVIKSLKAKHLGGYAADVYEEEGPLFFENHADDIIEDDILERLIAFPNVVFTGHQAF 300 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 LT EAL++I+ + LQ++S+ E G+ P+ LV Sbjct: 301 LTKEALSNIAHSILQDISDAEAGKEMPDALV 331 >UniRef50_B2JFX7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=cellular organisms RepID=B2JFX7_BURP8 Length = 335 Score = 416 bits (1071), Expect = e-115, Method: Composition-based stats. Identities = 169/329 (51%), Positives = 220/329 (66%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++S++QYD + N +FG+EL F + L TA A G + VC FVND Sbjct: 1 MRMMLFSSRQYDIDTFTEANAAFGYELHFQESHLDADTAVLAEGYDVVCPFVNDSVDAAT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G + IALR AGFN+VDL AA+ LG+ VVRVPAY P AVAEHA+G+++ LNR++ Sbjct: 61 LEALHAGGARLIALRSAGFNHVDLAAAQRLGIGVVRVPAYSPYAVAEHAVGLILALNRKL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA- 179 RA RTR+ +FSL GL GF ++GKT GVIGTG IG RI+ GFGM++LA DP P A Sbjct: 121 ARAVARTREGDFSLNGLLGFDLHGKTVGVIGTGIIGRCFGRIMAGFGMQVLAHDPGPPAT 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 L LG YV L TL ++SD++SLHCPL P YHL++ A +MK G M++NT RG L++ Sbjct: 181 ELLALGGRYVPLDTLLADSDIVSLHCPLLPSTYHLIDSHALAKMKRGAMLINTGRGGLVE 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S A + ALK+ ++G LG+DVYE E +FFED SN +QDDV RL NV+ T HQAF Sbjct: 241 SNALVGALKSGQLGHLGLDVYEEEGGIFFEDHSNLPLQDDVLARLLMFPNVIVTAHQAFF 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+T I+QTTL N+ G T N + Sbjct: 301 TREAMTEIAQTTLGNVEAWRDG-TPRNVV 328 >UniRef50_B6HIS7 Pc21g23650 protein n=11 Tax=cellular organisms RepID=B6HIS7_PENCW Length = 347 Score = 415 bits (1067), Expect = e-114, Method: Composition-based stats. Identities = 171/332 (51%), Positives = 222/332 (66%), Gaps = 4/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFE---LEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 MKLAV+S K YD+ Y QV E E +E+ F L+E+T A GC+AVC+FVND Sbjct: 1 MKLAVFSAKSYDRTYFDQVREQHFPELCTIEYHAFALSEETVPLAQGCDAVCVFVNDTLD 60 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 VL L +G++ I LRCAGFN+V L+ A+ELGL V VPAY PEAVAE A+ ++ TLN Sbjct: 61 ERVLRALHAYGIRAILLRCAGFNHVHLETAEELGLFVANVPAYSPEAVAEFAVALIQTLN 120 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+ HRAY R R+ NF++EGL G T++GKT G+IG G+IG+A RI GFG RLLA DP+ Sbjct: 121 RKTHRAYNRVREGNFNIEGLLGNTLHGKTVGIIGVGRIGLAAARIFHGFGCRLLAHDPFA 180 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + G VDL TL ES ++SLHCPLT HL+NE +++ G ++VNTSRG L Sbjct: 181 GEEFRQFG-TLVDLDTLLQESHIVSLHCPLTDSTKHLINEETLARIRPGSLLVNTSRGGL 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID+ A I+ALK +++G L +DVYE E ++F+ D S ++I DDV RL HNVL GHQ Sbjct: 240 IDTAAVIQALKTKQLGGLALDVYEAEGEIFYNDHSGEIIDDDVLMRLMTFHNVLICGHQG 299 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 F T EAL I++ TL NLS+L +C N LV Sbjct: 300 FFTREALEEIAEVTLGNLSDLVSARSCKNSLV 331 >UniRef50_D2LI76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LI76_RHOVA Length = 347 Score = 414 bits (1065), Expect = e-114, Method: Composition-based stats. Identities = 170/330 (51%), Positives = 226/330 (68%), Gaps = 1/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A +S + +L + N +G EL FF L+ +TA+ A G AVC FV D Sbjct: 1 MRIAFFSEHAFQTPFLIEANREYGHELVFFKEQLSRRTAQLAAGFVAVCPFVTDKLDAET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L G K IALR AGFNN+DL AA+ LGL V+RVPAY P A+AEHA+ +M+ LNRRI Sbjct: 61 LRILADGGTKLIALRSAGFNNLDLAAAERLGLCVMRVPAYAPTAIAEHAVALMLALNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + AY R R+ NFSL+ L GF M G+T G++GTGKIG ++ RI+ GFG +L +D Y + A Sbjct: 121 NHAYNRVREGNFSLDHLVGFNMEGRTVGIVGTGKIGESLARIMHGFGCHILGYDIYQNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + LG++YVDLPTL SESD++SLHCPLTPE HL+NE + MK G M++NT+RG L+++ Sbjct: 181 CIALGMKYVDLPTLLSESDIVSLHCPLTPETKHLINEETLKLMKPGSMLINTARGGLVNA 240 Query: 241 QAAIEALKNQK-IGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A IEALK + + +GMDVYE E LFF D S+ +IQDDVF L+ NV+ TGHQAFL Sbjct: 241 EAVIEALKRKDGLAYVGMDVYEREEGLFFSDHSSSIIQDDVFELLTTMRNVIVTGHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EAL I+ TTL N+++ E G P ++ Sbjct: 301 TREALAEIAHTTLGNVADYELGTPNPKNVL 330 >UniRef50_C5K2M9 D-lactate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5K2M9_AJEDS Length = 392 Score = 412 bits (1061), Expect = e-114, Method: Composition-based stats. Identities = 153/330 (46%), Positives = 214/330 (64%), Gaps = 1/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S ++Y++ L++ N+ F +EL +F L+ +T A G AV FV+D V Sbjct: 59 MKVAVFSFQEYERTALERFNQRFQYELVYFSAPLSTETVSLAAGSVAVSTFVSDHVDAEV 118 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G+K +ALRCAG ++VDL AA E + V+RVPAY A+AE+ IG+++TLNR I Sbjct: 119 LEVLADAGIKLVALRCAGHDSVDLQAASENHITVMRVPAYSSYAIAEYTIGILLTLNRNI 178 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 H+A R R NF L GL G +YGKT G+IGTG+IG A+ LK GFG R++A D Sbjct: 179 HKASTRVRTGNFDLNGLVGSNIYGKTVGIIGTGRIGAAVATTLKLGFGCRVIANDLDAHL 238 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++GV+YVD TLF SD I LHCPLT + H++N + + MK V++VNTSRG LID Sbjct: 239 ELEKIGVDYVDQDTLFRSSDFICLHCPLTKQTRHIINPESLQLMKPEVILVNTSRGGLID 298 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A +++L+N +I +DVYE E L F+ S + I D +RL + NV+ TGHQAFL Sbjct: 299 TPALLDSLENGRIRGCALDVYERENSLLFQKSSMEEIDDPTLKRLVSLPNVILTGHQAFL 358 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EA+ +I++TTL+N+ N G+ N V Sbjct: 359 TQEAIDAIAETTLKNIQNFLAGKVDVNRAV 388 >UniRef50_B4SP29 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=cellular organisms RepID=B4SP29_STRM5 Length = 334 Score = 412 bits (1060), Expect = e-114, Method: Composition-based stats. Identities = 174/332 (52%), Positives = 228/332 (68%), Gaps = 5/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF----GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 M++AV+S + YD+++L++ N+ GF +FD L TA A C AVC+FVND Sbjct: 1 MQIAVFSARPYDRRFLEEANQRDAAGDGFAFVYFDVALDVHTAALAQDCAAVCVFVNDRL 60 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 PVL L GV+ + LRCAGFNNVDL AAK L L V RVPAY PEAVAEHA+ ++MTL Sbjct: 61 DAPVLRALHALGVRAVLLRCAGFNNVDLAAAKALDLFVARVPAYSPEAVAEHALALVMTL 120 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 NR+ HRAY R R+ NF L+GL G T++G+T G++GTGKIG+A RI +G G +L DPY Sbjct: 121 NRQTHRAYNRVREGNFMLDGLLGRTLHGRTVGIVGTGKIGLATARIFRGMGCIVLGHDPY 180 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 PS+A +G E V L L + +D++SLHCPLTPE +HL+N+A+ +MK G M+VNTSRGA Sbjct: 181 PSSAFGGIG-EMVGLDELLARADIVSLHCPLTPETHHLINDASLARMKPGAMLVNTSRGA 239 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D+ A I ALK++++G L +DVYE E LFF+D S ++I D+ F+RL NVL TGHQ Sbjct: 240 LVDTHAVIRALKSRRLGHLAIDVYEQESALFFQDLSGEIIDDEAFQRLMTFPNVLVTGHQ 299 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T EAL IS TL NL + G C N + Sbjct: 300 GFFTVEALQEISAITLGNLQDFAAGRPCANRV 331 >UniRef50_C7QLW6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=19 Tax=cellular organisms RepID=C7QLW6_CYAP0 Length = 336 Score = 412 bits (1060), Expect = e-114, Method: Composition-based stats. Identities = 172/329 (52%), Positives = 233/329 (70%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S + YD+++L N + EL +F+ LL KTA A+G AVC+FVND+ Sbjct: 1 MKVAVFSAEAYDRQFLNAANANADHELVYFETLLEPKTASLAHGFPAVCVFVNDNLDPET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L G K +ALRC GFNNVD+ AA +LG+KVVRV Y P +VAE AIGM++ LNR+ Sbjct: 61 LKILADQGTKLVALRCTGFNNVDVTAAAQLGIKVVRVSVYSPYSVAEFAIGMILVLNRKF 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R RD NFSL GL GF ++G T GVIGTGKIG+ I+ GFG LL +D YP+ Sbjct: 121 HKAYNRVRDDNFSLNGLMGFDLHGCTVGVIGTGKIGLIFAEIMHGFGCHLLGYDLYPNPH 180 Query: 181 ALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + YVDL LF+ SD+ISLHCPLTPEN++L+N +MK GVM++NTSRG LID Sbjct: 181 FETMANAHYVDLSDLFTNSDIISLHCPLTPENHYLINTETIAKMKPGVMLINTSRGKLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++AAI+ +K+ +IGSLG+DVYE E +LFF D S+ +IQDD F+ L + NV+ T HQAFL Sbjct: 241 TKAAIKGIKSGQIGSLGIDVYEEEDNLFFRDLSDTIIQDDTFQLLQSFPNVVITAHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A++ I+ TT++++++ E+G T NE+ Sbjct: 301 TRNAISQIADTTIESITDFEQGNTLKNEI 329 >UniRef50_Q22CX9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain containing protein n=3 Tax=cellular organisms RepID=Q22CX9_TETTH Length = 359 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 155/333 (46%), Positives = 218/333 (65%), Gaps = 5/333 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFE----LEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 ++AV+S K+YD K+ Q+NE E ++F+ L EKTA G + +C FVND + Sbjct: 23 RVAVFSAKKYDIKFFNQINEKLPIEKRIIFDYFEEELNEKTAILTQGYDVICPFVNDKLN 82 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 +P ++ L K+G+ IALRCAGFNN DL+ A++ +KVVRVPAY P AVAEH + ++++L Sbjct: 83 QPTIQTLAKNGIDLIALRCAGFNNTDLECAQKNNIKVVRVPAYSPHAVAEHTMALLLSLV 142 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+IH+AY RT+D NFSL+GL GF +Y K G+ GTGKIG + I +GFGM +L DPYP Sbjct: 143 RKIHKAYNRTKDGNFSLDGLLGFDLYKKKIGIFGTGKIGQTFMGICQGFGMEILCHDPYP 202 Query: 178 SAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + + YVD TLF E D+ISLHCPLT ++++ + MK G +I+NT RG Sbjct: 203 NEEVVKKYNARYVDQATLFKECDIISLHCPLTFSTQYVIDRKTIDIMKKGAIIINTGRGK 262 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+ + I ALK+ ++G + +DVYE+E FF+D S DVI DD RL NV+ T HQ Sbjct: 263 LMRTDEVIAALKSGQLGGVALDVYEHEEGYFFKDVSADVIYDDDLARLLMYPNVIVTSHQ 322 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AF T EA+T+I QTT+ N+ ++ E C N ++ Sbjct: 323 AFFTQEAITAICQTTIDNILKIKANEPCDNMVL 355 >UniRef50_B5EQZ7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Bacteria RepID=B5EQZ7_ACIF5 Length = 331 Score = 405 bits (1041), Expect = e-111, Method: Composition-based stats. Identities = 161/328 (49%), Positives = 219/328 (66%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ V S + YD+++L N EL F + L+ TA A G A+C FV+D Sbjct: 1 MRCLVTSARPYDEQFLSAAN-HGRHELVFVETALSADTAFIAQGYPAICPFVDDTLDAKT 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE + + G K + LR GFN+VD+ AA++ G+ V+RV Y P AVAE+A+G+M+TLNR + Sbjct: 60 LETIARLGTKLLVLRSTGFNHVDMPAAEKYGITVMRVRDYSPYAVAEYAVGLMLTLNRHL 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R RD NF L+GL GF M+GKT G+IGTGKIG A+ RIL G G LL +D + A Sbjct: 120 HKAYNRVRDGNFLLDGLLGFDMHGKTVGIIGTGKIGQALARILHGMGCHLLGYDTVANPA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LELGV YV L L +S ++SLH PL PE HL+N F M +G M++NTSRG LID+ Sbjct: 180 CLELGVAYVPLEELLVKSQIVSLHVPLLPETRHLMNAERFALMPDGAMLINTSRGPLIDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I ALK++ +G++G+DVYE E +L+F+D +D+I DD F RL NV+ TGHQAF T Sbjct: 240 TALIAALKSRHLGAVGLDVYEEEAELYFKDHCDDIICDDSFERLLTFPNVIITGHQAFFT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +EALT+I++TT+QNL + G+ PN + Sbjct: 300 SEALTTIARTTIQNLDDYSDGKDNPNCV 327 >UniRef50_UPI0001AEC4CE D-lactate dehydrogenase n=1 Tax=Alteromonas macleodii ATCC 27126 RepID=UPI0001AEC4CE Length = 346 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 160/320 (50%), Positives = 220/320 (68%), Gaps = 6/320 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFG------FELEFFDFLLTEKTAKTANGCEAVCIFVNDD 55 +A +ST+ Y+ ++ E+ FF+ L TA + +G V +FVNDD Sbjct: 20 NIAFFSTRSYEHALFSELLETLNGASDKTINATFFEHPLNASTAASCSGFSDVVVFVNDD 79 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 +R +E LK GVK+IALRCAGFNNVD+DAA + G+ V RVPAY PE VAEH I +++T Sbjct: 80 INRKTIEALKLCGVKHIALRCAGFNNVDVDAAAKAGITVSRVPAYSPETVAEHTIALILT 139 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 LNR+ H+AY R R+ NF+L GL GFT++GKT GVIGTGKIG A++RIL GFG +L FDP Sbjct: 140 LNRKTHKAYNRVREGNFNLGGLMGFTLHGKTVGVIGTGKIGQAVIRILLGFGCHVLCFDP 199 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 +P+ +G YV L L +S +++LHCPL +++H++N + ++M GVM++NTSRG Sbjct: 200 HPNNDVTTMGAHYVTLNELLEKSVIVTLHCPLNEQSHHIINAKSIDKMPQGVMLINTSRG 259 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D A I+ LK++KIG LG+DVYE E +LFF D S D+IQDD+F+RL+ NVL TGH Sbjct: 260 GLVDDNAIIKGLKSKKIGYLGLDVYERESELFFNDHSQDIIQDDIFQRLTTFPNVLITGH 319 Query: 296 QAFLTAEALTSISQTTLQNL 315 Q F T EAL I++ T+ N+ Sbjct: 320 QGFFTLEALEEIAKITVNNI 339 >UniRef50_A7FYM9 D-lactate dehydrogenase n=10 Tax=Clostridium RepID=A7FYM9_CLOB1 Length = 336 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 129/325 (39%), Positives = 197/325 (60%), Gaps = 2/325 (0%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK 65 Y + + ++ +E +G ++ A A G + + I ND +R LE++K Sbjct: 11 YCVRPDEVDSFKKFSEKYGHTVDLIPDSFGPNVAHLAKGYDGISILGNDTCNREALEKIK 70 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 G+KY+A R AG NN+D DAAKE G+ V VPAY P +V+E IG+ ++L R+I A + Sbjct: 71 DCGIKYLATRTAGVNNIDFDAAKEFGINVANVPAYSPNSVSEFTIGLALSLTRKIPFALK 130 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR-LLAFDPYPSAAALEL 184 R NF+L GL G + T GVIGTG+IG+ ++ GFGM+ ++ +D + + A + Sbjct: 131 RVELNNFALGGLIGVELRNLTLGVIGTGRIGLKVIEGFSGFGMKKMIGYDIFENEEAKKY 190 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 +EY L +F E+D+I+LH PLT +NYH++ + + +MK+GV I+N +RGALIDS+A I Sbjct: 191 -IEYKSLDEVFKEADIITLHAPLTDDNYHMIGKESIAKMKDGVFIINAARGALIDSEALI 249 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 E LK+ KI +D YE E+ +F +K N+++QDD RL + NV+ T H F T EA+ Sbjct: 250 EGLKSGKIAGAALDSYEYEQGVFHNNKMNEIMQDDTLERLKSFPNVVITPHLGFYTDEAV 309 Query: 305 TSISQTTLQNLSNLEKGETCPNELV 329 +++ + TL NL E TC N+ V Sbjct: 310 SNMVEITLMNLQEFELKGTCKNQRV 334 >UniRef50_C0A4H0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Opitutaceae bacterium TAV2 RepID=C0A4H0_9BACT Length = 345 Score = 403 bits (1036), Expect = e-111, Method: Composition-based stats. Identities = 160/328 (48%), Positives = 217/328 (66%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S+K YD+++ N +L +F+ LT +TA A+G EAVC FVND Sbjct: 1 MKIAVFSSKSYDRRFFDAANTLHRHQLSYFEARLTRETAPLAHGFEAVCAFVNDRLDSGA 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L + GV + LR AG+N+ DL+AA +L + V VP Y P +VAEHA +M+ LNRRI Sbjct: 61 LARLSEAGVNLLLLRSAGYNHADLEAAADLNIVVTHVPNYSPHSVAEHAAALMLALNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A+ R R+ NFS+EGL GF M+GKTAG+IG G IG RIL+GFG ++LA+DP PS Sbjct: 121 PHAFVRVREGNFSIEGLLGFDMHGKTAGLIGAGHIGAITGRILQGFGCKVLAYDPAPSEQ 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+ E+ L + S SD++SLHCPLTP HL+ K G M++NTSRG LID+ Sbjct: 181 AVAANFEFGMLEDVISASDIVSLHCPLTPSTRHLIGRLTLPWFKRGAMLINTSRGGLIDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A IE+L+N +GSLG+DVYE+E ++FFED S + DDVF RL A NVL TGHQ F T Sbjct: 241 RAVIESLENGLLGSLGIDVYEDEAEIFFEDHSRQGLGDDVFSRLIAMPNVLVTGHQGFFT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA+ +I++T+L+ ++ G TC + L Sbjct: 301 EEAMQTIAETSLKAATDFAAGRTCAHVL 328 >UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHI0_ARCPR Length = 525 Score = 402 bits (1034), Expect = e-111, Method: Composition-based stats. Identities = 94/329 (28%), Positives = 163/329 (49%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V ++ + + G E++ + E+ + +A+ + +R V Sbjct: 1 MKVLV--ADPIAEEAID-FMKKNGLEVDVKTDISHEELLEVIQDYDALIVRSRTRVTRDV 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ KK +K I G +N+D+D A E G+ VV P + + AEH IG+++++ R+I Sbjct: 58 IDRAKK--LKIIGRAGVGVDNIDVDYATEKGIVVVNAPGGNSVSAAEHTIGLILSIARKI 115 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + ++ + + G + GKT G++G G+IG + + ++ F M +LA+DPY S Sbjct: 116 PQADRSVKEGKWERKKFVGIELRGKTLGIVGLGRIGYEVAKRMRCFEMNILAYDPYVSEE 175 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +G + V L L SD+I++H P T E +++ FE MK+GV I+N +RG ++D Sbjct: 176 RAKSVGAKLVSLEELLRNSDIITIHVPKTKETEKMISYKEFEIMKDGVYIINAARGGIVD 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A +AL + K+ +DVYE E D L NV+ T H Sbjct: 236 EKALYDALVSGKVAGAALDVYEKEPP-------------DKDNPLLKLENVVTTPHIGAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA + T +++ N KG N + Sbjct: 283 TREAQMMVGMTVAEDIVNFFKGLPVKNAV 311 >UniRef50_Q9P7Q1 2-hydroxyacid dehydrogenase homolog 2 n=2 Tax=Schizosaccharomyces pombe RepID=DDH2_SCHPO Length = 332 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 143/319 (44%), Positives = 214/319 (67%), Gaps = 1/319 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++S++ YD+ ++ N++F E+ + +F L + T A + VC+FVND Sbjct: 1 MRVVLFSSQSYDRGPFEEANKTFNHEIIYHNFSLNKDTVSLAGKAQVVCVFVNDQVDADT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L ++GVK +ALRC G+NNV+L AA E + VV VP+Y P AV+E +G++++LNR+I Sbjct: 61 LKALAENGVKLVALRCGGYNNVNLKAASEYKITVVHVPSYSPFAVSEFTVGLLLSLNRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 HRAY R R+ +F++ GL G ++GKT GVIGTGKIG + + K GFG +LA+D P Sbjct: 121 HRAYVRVREDDFNIVGLLGCDIHGKTVGVIGTGKIGSNVAKCFKMGFGCDVLAYDINPDK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 GV++V+ + ++D + LHCPLTP H++N + MK GV IVNTSRG LID Sbjct: 181 KLENYGVQFVEQNEVLKKADFLCLHCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A ++A+ + ++G +DVYE ER+LF++D SN+VI+D F+RL NVL T HQAF Sbjct: 241 TKALVDAIDSGQVGGCAIDVYEGERNLFYKDLSNEVIKDSTFQRLVNFPNVLVTSHQAFF 300 Query: 300 TAEALTSISQTTLQNLSNL 318 T EAL SI+ TTL++ S+ Sbjct: 301 TTEALCSIAHTTLKSASDF 319 >UniRef50_B9ZMK9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZMK9_9GAMM Length = 331 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 157/320 (49%), Positives = 218/320 (68%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S +Q+D ++L + G E + LTE+T A G +AVC+F NDD R V Sbjct: 1 MKVAVFSIQQHDHEHLVPGLTAAGMEPVVYAERLTEETIHLAAGVDAVCVFTNDDLKRGV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ L G++ IALRC+G++N+D+ A+E G++V RVPAY P AVAEHA+ +++TLNR + Sbjct: 61 IDGLADQGIQVIALRCSGYDNLDVGRARERGVRVGRVPAYSPNAVAEHAVALLLTLNRSV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRA+ RTR +F L+ LTGF + G+T GV+GTG+IG RI+ GFG R+LA DPYP+A Sbjct: 121 HRAWDRTRRGDFRLDHLTGFDLVGRTVGVVGTGRIGQVFARIMLGFGCRVLAHDPYPNAE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +GVEY DL TL +ES V+SL CP+TPEN H++N +M G ++NT+RGAL+D+ Sbjct: 181 LQAVGVEYRDLDTLLAESSVVSLSCPMTPENRHMINADTLARMPRGAFLINTARGALVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AA AL + ++G +DVYE E LFF D S + D RL +VL TGHQAFLT Sbjct: 241 DAAEIALDSGQLGGFALDVYEAEAGLFFRDWSLAGLPDRRLARLMQRDDVLVTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEK 320 EALT+I+ TT+ NL+ L + Sbjct: 301 HEALTNIADTTVSNLTTLHQ 320 >UniRef50_B7KQC7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Methylobacterium extorquens group RepID=B7KQC7_METC4 Length = 335 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 161/328 (49%), Positives = 224/328 (68%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++AV+S K Y++ L +N +L +FD LL TA A G AV +FVND +R V Sbjct: 1 MRVAVFSAKNYERALLDDLNVGQEHDLTYFDALLEPGTASLAAGFTAVSVFVNDSVNRDV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L +L + G K +A RC GFN++DL+AA+E G++VVRV Y P +VAE A+G+++ LNR++ Sbjct: 61 LRQLAQGGTKLVATRCTGFNHIDLEAAEEFGIRVVRVVNYSPNSVAEFAVGLLLALNRKV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTR+ NF L+GL GF + +T VIGTGKIG RI+ GFG R++ FD + S Sbjct: 121 HRAYNRTREGNFRLDGLMGFDLVDRTVAVIGTGKIGTIFGRIMAGFGCRVIGFDVHRSPE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +G YVD + E+DVIS+HCPLTPE YH+++ ++K G +++NTSRG LID+ Sbjct: 181 FERIGGRYVDAAGV-EEADVISMHCPLTPETYHIVDARTLGRVKKGALLINTSRGGLIDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AAI+ALK+ ++G L +DVYE E +LF+ D S+ VI DDV +RL + NV+ TGHQAF T Sbjct: 240 DAAIDALKSGRLGGLAIDVYEQEAELFYRDLSSTVIPDDVIQRLISFPNVIVTGHQAFFT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL +I TTL+++S LE G NE+ Sbjct: 300 QEALETILGTTLKSISELEAGHPLTNEV 327 >UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehydrogenases n=3 Tax=Firmicutes RepID=A5D6D4_PELTS Length = 526 Score = 393 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 161/329 (48%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V +++ L+ + + G +++ D + ++ + + + + + Sbjct: 1 MKVLVLD--GVEEEGLKALRQEPGIQVDVKDKMSEDELVAAIGDYDGIIVRSATKVTARI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+ + +K + G +N+D+ AA G+ VV P + AVAEH I MM++L R I Sbjct: 59 IEKAAR--LKVVGRAGVGVDNIDVPAATARGILVVNAPEGNTLAVAEHTIAMMLSLARNI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A R + + G + GK GVIG G+IG A+ + +G M+++A+DPY + Sbjct: 117 PQANASLRAGKWDKKSFMGVELRGKVLGVIGLGRIGSAVAKRAQGMEMKVVAYDPYINEE 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LGV + L L ++D I++H PLT E+ ++L E AF MK+GV I+N +RG ++D Sbjct: 177 KAGLLGVTLLSLEELLKQADFITVHLPLTRESKYMLGEKAFSLMKDGVRIINCARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA A+K+ K+ +DV+E E + L N + T H Sbjct: 237 EQALYNAMKSGKVAGAALDVFEKEP--------------NTDSPLFEFKNFIATPHLGAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S++ + + KGE N + Sbjct: 283 TQEAQLSVATDVAREVVAALKGELVKNAV 311 >UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellular organisms RepID=SERA_ARCFU Length = 527 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 99/329 (30%), Positives = 168/329 (51%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V + ++ + + ++ G E+E + E+ + EA+ + V Sbjct: 1 MKVLV--AEPISEEAIDYMRKN-GLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEV 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ K +K I G +N+D++AA + G+ VV P + + AEHAI +M+ R+I Sbjct: 58 IQAAK--NLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKI 115 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + ++ + + G + GKTAGVIG G++G + + K M +LA+DP+ S Sbjct: 116 PQADRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKE 175 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A ++GV+ VD TL + SDVI++H P T E L+ + FE+MK+GV++VN +RG ++D Sbjct: 176 RAEQIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVD 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A EA+K K+ + +DVYE E L NV+ T H A Sbjct: 236 EAALYEAIKAGKVAAAALDVYEKEPP-------------SPDNPLLKLDNVVTTPHIAAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ +++ N+ KG N + Sbjct: 283 TREAQLNVGMIIAEDIVNMAKGLPVRNAV 311 >UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WVY8_ALIAD Length = 529 Score = 388 bits (997), Expect = e-106, Method: Composition-based stats. Identities = 94/329 (28%), Positives = 159/329 (48%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + T + + ++ G E+ L ++ + +A+ + +R V Sbjct: 1 MATKILVTDDISQAGIDILSGLQGAEVVVRTNLAPDELKEAIADADALVVRSQTRVTRDV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E KK +K I G +N+DL+AA G+ V+ P + A AEH MM++L R I Sbjct: 61 IESAKK--LKVIGRAGVGVDNIDLEAATRRGILVINAPDGNTIAAAEHTFAMMISLARHI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A++ N++ + G + GKT V+G G+IG + + K FGM +L +DP+ + Sbjct: 119 PAAHRDLLQGNWNRKKWIGVELRGKTLAVLGMGRIGTEVAKRAKAFGMTVLGYDPFLTEE 178 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGV+ DL T E+D I++H PLT E +H+++ QMK GV I+N +RG +ID Sbjct: 179 RAQSLGVKRCDLDTAIREADFITVHTPLTKETHHMIDAGRIAQMKEGVRIINCARGGIID 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A EAL+ ++ +DV+E E + L C NV+ T H Sbjct: 239 EVALAEALEAGRVAGAAIDVFEQEPL-------------PMDHPLRRCPNVVLTPHLGAS 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ + + + + +T + + Sbjct: 286 TVEAQENVAIQVAEEIVQVLRDDTFEHAV 314 >UniRef50_C5P2R3 D-lactate dehydrogenase, putative n=5 Tax=cellular organisms RepID=C5P2R3_COCP7 Length = 335 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 134/329 (40%), Positives = 194/329 (58%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A +S ++K L+ N+ + EL FF L+E A G A+ FVND + Sbjct: 1 MRIAFFSILPHEKDALEAFNKEYHHELVFFKDSLSEANVALAAGFPAISAFVNDQLDSTI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + L + G +ALRC+G++ VD+ AA G+ V RVPAY PEA+ E+ +GM++ L+RR Sbjct: 61 MRALAESGTMLVALRCSGYDRVDIKAATANGITVTRVPAYSPEAIVEYTVGMLIALDRRT 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 A+QR R NF L G G ++GKT G++GTG+IG + R+ K GF +LA D YP+A Sbjct: 121 PHAWQRVRAGNFDLTGFVGHGIHGKTVGIVGTGRIGAGVARVFKNGFHCEVLANDLYPNA 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + GV YV+ L SD++ LHCPLT H++ MK ++VNTSRGAL++ Sbjct: 181 TLEQDGVRYVEFKELLKSSDIVCLHCPLTTATRHIIKAETLAIMKQNAILVNTSRGALVN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S + AL+ +I +DV E E FF+ + DDV RRL + NV+ TGHQAFL Sbjct: 241 SSDLLHALEKGRIRGCALDVVEGEEKYFFQSSNQAKHIDDVLRRLISLPNVMITGHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ SI++TTL+++ N E G N + Sbjct: 301 TRGAVDSIAKTTLKSIRNFESGTLKENVV 329 >UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Archaea RepID=SERA_METTH Length = 525 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 96/297 (32%), Positives = 147/297 (49%), Gaps = 17/297 (5%) Query: 33 LLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGL 92 + E+ +A+ + +R V+E + +K IA G +NVD+ AA + G+ Sbjct: 32 ITPEELLDAIKDFDAIVVRSRTKVTREVIEAAPR--LKIIARAGVGVDNVDVKAATDRGI 89 Query: 93 KVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGT 152 V+ P VAEH+IG+M+ L R+I A + ++ + G + GKT G+IG Sbjct: 90 MVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGM 149 Query: 153 GKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPEN 211 G+IG ++ K FGM ++ +DPY S A E+GV DL TL ESD++++H PLTPE Sbjct: 150 GRIGSQVVVRTKAFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPET 209 Query: 212 YHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDK 271 HL++E F+ MK+ IVN +RG +ID A ALK+ +I +DV+E E Sbjct: 210 RHLISEDEFKLMKDTAFIVNCARGGIIDEDALYRALKDGEIAGAALDVFEEEPPEG---- 265 Query: 272 SNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 L NV+ T H T+EA + + + +G N L Sbjct: 266 ----------SPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVL 312 >UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms RepID=A7HM61_FERNB Length = 317 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 105/332 (31%), Positives = 163/332 (49%), Gaps = 22/332 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRPVL 61 + V+ T +K + + E F ++ + L+ E+ K A +A+ + D + + Sbjct: 1 MRVFVTYAIPEKGINMLKERFEVDVYTGEEFLSKEEMIKRAEYADAIVTQLRDPIDKEFI 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 LKK K IA G+NN+D++AAKE G+ V P EA A+ A +++ + RRI Sbjct: 61 YSLKKA--KIIANYAVGYNNIDIEAAKERGIYVTNTPGVLTEATADIAFALILAVARRIV 118 Query: 122 RAYQRTRDAN---FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-- 176 + + R+ + + G+ +YGKT GVIG G+IG A+ R GFGM ++ ++ Sbjct: 119 ESDKFVREGKFVGWKPKLFLGYDLYGKTLGVIGMGRIGQAVARRALGFGMNIVYYNRNRL 178 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 P + +YV++ L SD ISLH PLT E YHL+N+ +MK ++VNT+RG Sbjct: 179 PEEIEKQYNAKYVNIDELVEISDYISLHTPLTKETYHLINKERIAKMKPNAILVNTARGP 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D QA EALK ++I G DVYENE L L NV+ H Sbjct: 239 VVDEQALYEALKERRIAGAGFDVYENEPVLTPG--------------LEKLDNVVLLPHI 284 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E +S+ N+ G+ N + Sbjct: 285 GSATYETRDKMSEIVAINVMEALDGKRPSNCV 316 >UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=5 Tax=Archaea RepID=A3DM01_STAMF Length = 311 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 99/322 (30%), Positives = 164/322 (50%), Gaps = 19/322 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + +K L+++ S GF++ + ++ ++ + EA+ + SR V+E Sbjct: 2 VKILVAAPLHEKALEKLR-SAGFQIVYEEYPSEDRLVELIKDVEAIIVRSKPKVSRRVIE 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K +K IA G +N+DLDAA E G++V PA ++VAE AIG+M+ + R+I Sbjct: 61 AAEK--LKVIARAGVGLDNIDLDAANEKGIQVFNAPAAPTQSVAELAIGLMIDVLRKIAF 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPY--PSA 179 A ++ R+ ++ + G + G G+IG G+IG A+ RI GFGM+++ +D P Sbjct: 119 ADRKMREGVWAKKQCLGHELRGIVLGIIGMGRIGTAVARIAYHGFGMKIIYYDVRRCPKD 178 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 EL + VDL TL +D++S+H PL P HL+NE MK +++NT+RG ++D Sbjct: 179 VEKELDAKCVDLETLLKTADIVSIHVPLVPSTKHLINEEKLRLMKKSAILINTARGGVVD 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A ++ALK I G+DV+E E L+ NV+ T H Sbjct: 239 TDALVKALKEGWIAGAGLDVFEEEPL-------------PPNHPLTKLDNVVLTPHIGAN 285 Query: 300 TAEALTSISQTTLQNLSNLEKG 321 T EA ++ + KG Sbjct: 286 TVEAQERAGIEVVEKIIEFFKG 307 >UniRef50_A8SQC5 Putative uncharacterized protein n=4 Tax=Clostridiales RepID=A8SQC5_9FIRM Length = 343 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 153/330 (46%), Positives = 217/330 (65%), Gaps = 3/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M + Y TK+YD+ + + +++ + L+ +TA+ A G EA+C FV+ D S Sbjct: 14 MNILFYDTKKYDRDSFDAIKGGYPQLCIDYVEADLSVRTARLARGYEAICAFVSSDVSAA 73 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V+ L + GVK I +RCAGFNNVDLDA ++ G+ V+RVP Y PEAVAEHA+ + M +NR+ Sbjct: 74 VVNALSEVGVKLILMRCAGFNNVDLDATEKCGMTVLRVPGYSPEAVAEHAMALAMAVNRK 133 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +H++Y + R+ NFSL GLTG +GK AG++GTGKIG AM RI GFGM+++A+D Y + Sbjct: 134 LHKSYIKVRENNFSLVGLTGMNFHGKIAGIVGTGKIGAAMARICHGFGMKVIAYDMYKNP 193 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V YV+L LF SD+ISLHCPLT + YHL+N QMK+ V++VNTSRGALI Sbjct: 194 ELD--FVTYVELQELFRVSDLISLHCPLTDDTYHLVNADTIAQMKDKVILVNTSRGALIK 251 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ I ++++K +G+DVYE E FE++ +D+++ + RL + NV+ T HQ FL Sbjct: 252 TEDLIAGIRSRKFFGVGLDVYEEETGNVFENREDDILETSITARLLSFPNVIVTSHQGFL 311 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EAL +IS+TTL N N E G LV Sbjct: 312 TEEALEAISRTTLDNAVNFEAGNIDKANLV 341 >UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms RepID=GYAR_THEPD Length = 339 Score = 380 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 93/332 (28%), Positives = 157/332 (47%), Gaps = 23/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDF--LLTEKTAKTANGCEAVCIFVNDDGSRP 59 + VY T+ + L + E + E+ + +A+ + D Sbjct: 3 RPKVYVTRIIPEPGLSMLKECCDVVVHESKDWPPSREELLRNIRDKDALLCLLTDKIDAE 62 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V++ +K I+ GF+++D+ A + G+ V P +AVAE +G+++ + RR Sbjct: 63 VMDAAP--NLKVISTYSVGFDHIDIPEATKRGIYVTHTPGVLTDAVAEFTVGLILAVTRR 120 Query: 120 IHRAYQRTRDANFSLEG----LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD- 174 I A + R + LTG + GKT G++G G+IGVA + L F +++L +D Sbjct: 121 IVEADKIIRTGQWDKPWNPYFLTGPELKGKTIGLVGLGRIGVATAKRLSSFDVKILYYDI 180 Query: 175 -PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + +E+ DL TL +SD++S+H PLT E YHL+NE +MK ++NT+ Sbjct: 181 ERRWDVETVIPNMEFTDLDTLLEKSDIVSIHVPLTKETYHLINEERLRKMKKTAYLINTA 240 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG ++D++A ++ALK I +DV+E E L+ NV+ Sbjct: 241 RGPVVDTEALVKALKEGWIAGAALDVFEQEPL-------------PPNHPLTKFDNVVLA 287 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 H A T EA +++ +NL + KGE P Sbjct: 288 PHIASATIEARQRMAELAARNLIAVLKGEMPP 319 >UniRef50_Q54UF7 Putative D-lactate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=LDHD_DICDI Length = 340 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 149/331 (45%), Positives = 220/331 (66%), Gaps = 3/331 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ ++S+K Y K+ ++N+ F +E+ + K+ A G EAVC FVNDD S+ V Sbjct: 1 MKITLFSSKPYWVKWFNELNK-FSYEINYVTSACDIKSVNEAKGSEAVCCFVNDDLSKEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E L +G K I +RCAGFN VDLD A +LG+ V+RVPAY P AV+E+A+ ++M LNR+ Sbjct: 60 IETLHSNGTKVILMRCAGFNKVDLDTANKLGIPVLRVPAYSPNAVSEYALSLIMALNRKT 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 H+A+ R RDANF + G+ GF M K G++GTG IG + R+LK GFG +++A+D + Sbjct: 120 HKAHDRVRDANFEINGMEGFNMVSKVYGIVGTGNIGEQLCRVLKLGFGAKVIAYDIIENK 179 Query: 180 AALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A ++G+EYV L ++ + DVISLH PL + +++N + E+M++GVMI+N SRGAL+ Sbjct: 180 AVTDIGIEYVKTLDEIWKQCDVISLHTPLNSQTKYMVNSESIEKMRDGVMIINVSRGALV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ AI LK+ KI SLGMDVYENE D F++D + +I+DD L + NV+ T HQA+ Sbjct: 240 NASDAIVGLKSGKISSLGMDVYENETDYFYQDHNGSIIKDDNLSLLISYPNVMITSHQAW 299 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EA++ I T+LQN + + + LV Sbjct: 300 YTKEAISCICGTSLQNFVDFRSNQIKKSNLV 330 >UniRef50_A8UL50 D-lactate dehydrogenase n=2 Tax=unclassified Flavobacteriales (miscellaneous) RepID=A8UL50_9FLAO Length = 351 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 142/329 (43%), Positives = 215/329 (65%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ VYS K ++ Y+++ N+ +++F L+ +TA A G EA+ IF D+ Sbjct: 17 MKVLVYSAKDFEIPYIEEANKRK-HKIDFTKDALSSETAMKAIGYEAISIFSADEACFIT 75 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+LK GVKYI LR G++N++L AA LG++V VPAY P A+AEH++ +++ LNR++ Sbjct: 76 IEKLKDFGVKYITLRSVGYDNINLRAASRLGIRVANVPAYSPYAIAEHSVALLLALNRKL 135 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + R NF+L L GF + KT G++GTGKIG M +I+ GFG +LL +D + Sbjct: 136 IESNFRVNHYNFNLNNLVGFDLNDKTVGIVGTGKIGAIMCKIMHGFGCKLLGYDIEENNT 195 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E + Y L L ++D+ISLH PL E + L+NE MK+GV+++NT+RG++++ Sbjct: 196 LKEYYNITYTSLKALCKQADIISLHVPLNTETHQLINEDLISFMKDGVILINTARGSVVN 255 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ I+ LKN KIG+LGMDVYENE+ +FF+D+S ++ DD+ +L+A NVL TGH AFL Sbjct: 256 TEDVIQGLKNGKIGALGMDVYENEKGVFFKDRSQNLPNDDLLLKLNAMPNVLITGHHAFL 315 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EALT+I++TT+ NL + NEL Sbjct: 316 TEEALTNIAETTIYNLDCWNLRKETENEL 344 >UniRef50_C9KNY1 D-lactate dehydrogenase n=2 Tax=Clostridiales RepID=C9KNY1_9FIRM Length = 432 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 149/329 (45%), Positives = 207/329 (62%), Gaps = 9/329 (2%) Query: 2 KLAVYSTKQYDKKYLQQVNES-----FGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 K+A + TK YD+ Y ++ + + EL++F LT++TA ANG +AVCIFVND+ Sbjct: 95 KVAFFGTKDYDRLYFSELAKDRGEGTYNVELKYFASRLTDETAHLANGYDAVCIFVNDEA 154 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 R V+E+L GV+ I LRCAGFNNVD AA E G+ V+RVPAY P AVAEHA+ + Sbjct: 155 PRSVIEQLHDGGVRLILLRCAGFNNVDKKAAAEYGITVLRVPAYSPYAVAEHAMATLQAA 214 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 NRR+H+AY + RD NF L GL G ++ K AG++GTG+IG M RI KG+GM ++ +D + Sbjct: 215 NRRLHKAYNKVRDNNFDLTGLLGVDLHNKVAGILGTGRIGQCMARICKGYGMTVIGWDAF 274 Query: 177 PSAAALELG-VEYVDLPTLFSESDVISLHCPLT---PENYHLLNEAAFEQMKNGVMIVNT 232 P+ E G + Y + S SD+IS+H PL YHL++E A MK+ VM+ N Sbjct: 275 PNKKLEEEGLLTYASKEEVLSRSDLISIHAPLIMGEGGTYHLIDEKAISLMKDDVMLTNA 334 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG LID++A I ALK K ++ +DVYE E + D S+DV +D+ RL V+ Sbjct: 335 ARGGLIDTEALIAALKKGKFHAVALDVYEGEDANVYTDHSSDVPTEDITGRLLMFPQVIL 394 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKG 321 T HQAF T EAL +I+ T++N N +G Sbjct: 395 TSHQAFFTREALQAIATVTMENARNFNEG 423 >UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1CAH7_SPHTD Length = 348 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 121/336 (36%), Positives = 180/336 (53%), Gaps = 14/336 (4%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 ++ + T ++ Y + F L E + A E V +F++ RP L Sbjct: 11 RVVFFETDSREQAYFGEAL--GPLAPVFHSEPLDEDSTHLAAEAEIVSVFIHSRLDRPTL 68 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L + ++ IA R G++++DL A E G+ V VP Y VAEH G+++ L+R IH Sbjct: 69 ERLPR--LRLIATRSTGYDHIDLAACAERGVVVTNVPYYGENTVAEHTFGLILALSRNIH 126 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 RAY RT+ +FSL GL GF + GKT GVIGTG IG+ ++RI KGFGM ++A D PS Sbjct: 127 RAYVRTQRGDFSLAGLEGFDLKGKTLGVIGTGSIGLHVIRIAKGFGMEVVAHDLRPSRIL 186 Query: 182 LE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E LG YV L L SD+ SLH P P +HL+N F +MK G +++NT+RG L+D+ Sbjct: 187 PEVLGFRYVPLDELLQVSDIASLHVPYLPATHHLMNRETFARMKRGSLLINTARGGLVDT 246 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDK--SNDVIQDDVFRRLSAC-----HNVLFT 293 ++ + AL + G+DV E E + E + + ++D + L NV+ T Sbjct: 247 ESLMWALDEGILAGAGLDVLEGEELIQEESQLLTQPAVEDKLRAVLRQHLLARRENVVIT 306 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H AF + EA+ I T++N++ G P +V Sbjct: 307 PHIAFYSTEAVHRIMDVTIENINAFLDGN--PQNVV 340 >UniRef50_C8W7M7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Bacteria RepID=C8W7M7_ATOPD Length = 334 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 150/325 (46%), Positives = 210/325 (64%), Gaps = 5/325 (1%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ Y + YDK ++ + +++ + LT TA A G +AVC FVN D S Sbjct: 1 MKILFYGAQSYDKDSFNLELPKYPDVSIDYIESNLTPMTAGFAKGYDAVCAFVNADASIL 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 LE L VK + +RCAGF+ VD++AAK+LG+ V RVPAY PEA+AEHA+G+ + NRR Sbjct: 61 TLEILAGFDVKLLLMRCAGFDAVDVNAAKDLGITVTRVPAYSPEAIAEHAMGLALAANRR 120 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 IHR Y R R+ NFSL GL G T++GKTAG++GTG+IG A+ RI KGFGM +L D YP+ Sbjct: 121 IHRGYNRIRENNFSLVGLVGETLHGKTAGIVGTGRIGAALCRICKGFGMHVLGADLYPNM 180 Query: 180 A---ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + + EYV L+ +D ISLH L E+YH++N+ +MK+GV++VNT+RGA Sbjct: 181 SLVNDEHVVDEYVSYDELWERADFISLHAFLNEESYHMINDKTIGKMKDGVVLVNTARGA 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D++A I + + KIG+ G+DVYE E ++D++ +V D V L + NV+ T HQ Sbjct: 241 LVDTKALIRGILSGKIGACGLDVYEEENPNVYKDRAAEVF-DSVTSTLCSFPNVVMTSHQ 299 Query: 297 AFLTAEALTSISQTTLQNLSNLEKG 321 AF T EAL+ I+Q TL N + KG Sbjct: 300 AFFTHEALSQIAQVTLDNATAFAKG 324 >UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=B8HPZ0_CYAP4 Length = 652 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 100/326 (30%), Positives = 159/326 (48%), Gaps = 18/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D+ + + + +++ L E+ + +A+ I ++ V+E Sbjct: 129 KVLVSDPIDQVGIDLLAQVA--QVDVRTDLSPEELIQIIPDYDALMIRSGTKVTQAVIEA 186 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 + +K I G +NVD+ AA G+ VV P + A AEH + MM++L+R I A Sbjct: 187 A--NQLKIIGRAGVGVDNVDVPAATRKGIVVVNSPEGNTIAAAEHTLAMMLSLSRHIPAA 244 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 Q + + + TG +Y KT GVIG GKIG + + + GM LLA+DPY S A Sbjct: 245 SQSVKSGKWDRKSFTGVEVYKKTLGVIGLGKIGSHVATVARAMGMNLLAYDPYLSNERAE 304 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ++G V+L LF+E+D I+LH P TPE HL+ +MK I+N +RG +ID A Sbjct: 305 QIGCRLVNLDLLFAEADYITLHLPKTPETQHLIKAETLARMKPTARIINCARGGIIDEAA 364 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +EALK KI +DV+ENE + + L V+ T H T E Sbjct: 365 LVEALKEGKIAGAALDVFENEP-----------LGESPLLSLGKE--VVLTPHLGASTEE 411 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A T+++ + + +L G+ + + Sbjct: 412 AQTNVAIDVAEQIRDLFLGKPVRSAV 437 >UniRef50_D2QQC4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QQC4_9SPHI Length = 329 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 131/323 (40%), Positives = 191/323 (59%), Gaps = 3/323 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M +A +ST +++ + Q + + +LT KTA A G AVC FVNDD SRPV Sbjct: 1 MNIAFFSTLSFEQAWFDQYRA--HHRITYIPEVLTTKTAHLAQGHNAVCTFVNDDLSRPV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L LK+ + + +RC G +NVDL A +LG+ ++ +Y P ++AEH + ++M + R + Sbjct: 59 LTLLKEMRIGVVGMRCMGTDNVDLQAITDLGMTLLHT-SYSPYSIAEHTVALLMGMVRHL 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A+ R + NF+++GLTG+ ++GKT G++GTG IG A +RI+ GFG ++LA+D P Sbjct: 118 PEAHNRVQARNFTIDGLTGYDLHGKTVGIVGTGHIGKAFIRIMLGFGCKVLAYDVCPDRR 177 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E+GV YV LP L +SDV+SLHCP T H++NE MK ++VNT RG L+D+ Sbjct: 178 LTEIGVTYVSLPELLRQSDVVSLHCPSTSITQHMINEQTLSLMKQSAILVNTGRGRLVDA 237 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + AL K+ DVYE ERD F D S + DD+ RL VL T HQ FLT Sbjct: 238 HAVLNALDAGKLAGYAADVYEGERDYFHYDYSGKSVPDDLLNRLRKHPGVLLTAHQGFLT 297 Query: 301 AEALTSISQTTLQNLSNLEKGET 323 +AL I+ + + S + +T Sbjct: 298 EDALRQIALSLINQFSFFDNKQT 320 >UniRef50_Q89388 A53R protein n=3 Tax=Chlorovirus RepID=Q89388_PBCV1 Length = 363 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 143/333 (42%), Positives = 207/333 (62%), Gaps = 8/333 (2%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 +A++S Y K +++ + + + L E TA AN C+A+ FVNDD S PVL+ Sbjct: 32 VAIFSAGNYVKDFIKPIESIC--TPVYIESSLNETTAALANKCDAINAFVNDDLSAPVLD 89 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 LK GV I LRCAGF+ +D++ AKELG V RVPAY P +VAE A+ MM L+R I Sbjct: 90 ILKNCGVSSITLRCAGFDRLDIEYAKELGFNVYRVPAYSPRSVAELALTHMMALSRNIQL 149 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 R + N+++EGL G + KT G+IGTGKI ++++K R++A+D Y + Sbjct: 150 VLPRVKTGNYTMEGLVGREITDKTIGIIGTGKIAQEFIKLVKPMAGRIIAYDVYENDIVK 209 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E+GVEY+ LP + ESDV+SLHCPL +H++NE + MK +I+NT+RG LID++A Sbjct: 210 EMGVEYMSLPDVIKESDVLSLHCPLMKSTFHMINEDTLKTMKKTAVIINTARGGLIDTEA 269 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDV------FRRLSACHNVLFTGHQ 296 I+AL++ I MDVYE+E LFF D++ I+D + F RL+ N + + H Sbjct: 270 LIDALESGVISGCAMDVYEHESGLFFTDRAVLPIEDRMKFWDKKFARLANLPNAIVSPHV 329 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AFLT EAL +I+ TT++NL++ KGE N +V Sbjct: 330 AFLTKEALKNIADTTIENLTSAFKGERNNNNMV 362 >UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=A1W7V5_ACISJ Length = 337 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 119/339 (35%), Positives = 187/339 (55%), Gaps = 16/339 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T++++ + Q++ G +L L N E + FV+ + V Sbjct: 1 MKILVVETEEWEHRACQRLLP--GHKLVCRSNALGPDEPTADNDAEVITPFVHSRLTAEV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L + + ++ IA R G++++DLD + G+ V VP Y VAEHA +++ ++R I Sbjct: 59 LAQFPR--LRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATVAEHAFALLLAVSRHI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +RTR +FS GL GF + GKT GV+GTG+IG ++ I KGFGM+++A+D +P AA Sbjct: 117 VTGAERTRRGDFSQHGLRGFELRGKTLGVLGTGRIGRRVIEIGKGFGMKIVAYDLFPDAA 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E LG EY+DL L S++DV++LH P TP+ +HLL + F MK G +++NT+RG ++D Sbjct: 177 VAEHLGYEYLDLHVLLSQADVVTLHVPATPQTHHLLGDPEFAAMKKGAVLINTARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFE---------DKSNDVIQDDVFRRLSACHNV 290 + A + AL +K+ + G+DV E + E + D+ L NV Sbjct: 237 TSALVRALSARKLRAAGLDVLPAEPLIREEAEIFRNDRRNSDTDLRALLADHVLLRFSNV 296 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 + T H A+ T EAL I TT+ N+ +G+ P LV Sbjct: 297 IVTPHVAYDTDEALRRILDTTIANIEAFARGQ--PRNLV 333 >UniRef50_C1DZN2 D-Lactate dehydrogenase n=2 Tax=Micromonas RepID=C1DZN2_9CHLO Length = 339 Score = 368 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 145/303 (47%), Positives = 193/303 (63%), Gaps = 11/303 (3%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 + + D LT +TA A GC A C+FVND ++ L GV++IA+RCAGF+ VDLDA Sbjct: 18 VRWLDVGLTPQTAPLAAGCNATCLFVNDRADAETIDALADLGVRFIAMRCAGFDRVDLDA 77 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKT 146 G+ V RVPAY P A+AEHAI MM+ LNR++ + + R N+SL GL GF M+GKT Sbjct: 78 CARRGVAVTRVPAYSPYAIAEHAIAMMLALNRQLMKGHARVVQGNYSLSGLVGFDMHGKT 137 Query: 147 AGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVD-LPTLFSESDVISLHC 205 G++GTGKIG +IL G G +LA+D + S A+ +GV+YVD + L ++SLHC Sbjct: 138 VGIVGTGKIGRCTAKILLGMGCEVLAYDVFQSKEAIAMGVKYVDTVQELLPRCQIVSLHC 197 Query: 206 PLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERD 265 PLT + YHL+++A F M+ G M+VNTSRG L+D+ A AL QKI + MDVYE+E Sbjct: 198 PLTDDTYHLMDDATFNLMRKGSMLVNTSRGGLVDTAALARALDAQKIACVAMDVYEHEAG 257 Query: 266 LFFEDKSNDVIQ----------DDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 LFFEDKS + D L++ NVL T HQAFLTAEAL +I+ TT++NL Sbjct: 258 LFFEDKSEETDATPGSSLSPDWDLSLGSLASRPNVLVTSHQAFLTAEALGNIASTTVENL 317 Query: 316 SNL 318 Sbjct: 318 REF 320 >UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HZG9_9BACT Length = 537 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 85/320 (26%), Positives = 148/320 (46%), Gaps = 17/320 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + + ++ + ++ GFE+ L ++ + + I + VL Sbjct: 6 KIKILVSDPISEEGINIF-KNAGFEVTVKAKLSPDELKAELAHYDGLVIRSGTKVTAHVL 64 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E + +K I AG +NVDL AA G+ V+ P + AEH + MMM++ RRI Sbjct: 65 EGATR--LKVIGRAGAGLDNVDLPAATNRGIVVMNTPGGNTITTAEHTVSMMMSMARRIP 122 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A R + G + KT G++G GKIG + + +G M ++A+DP+ +A Sbjct: 123 QANASNRSGKWEKSKFMGIELAHKTLGILGMGKIGSHVAHVAQGLLMNVIAYDPFLTAES 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A GV V + LF+++D+I++H PLTPE +L++ A+ +MK GV IVN +RG +++ Sbjct: 183 AARQGVTPVTVEELFAKADIITVHTPLTPETTNLISSASIAKMKKGVYIVNCARGGIVNE 242 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +AL++ + DV+ E L N + T H T Sbjct: 243 ADLAKALESGHVAGAAFDVFAEEPP-------------SPDNPLLKLDNFISTPHIGAAT 289 Query: 301 AEALTSISQTTLQNLSNLEK 320 EA +++ + + Sbjct: 290 KEAQENVALAVADQMVDYLA 309 >UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=cellular organisms RepID=A5IMH3_THEP1 Length = 308 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 106/318 (33%), Positives = 165/318 (51%), Gaps = 19/318 (5%) Query: 1 MKLAVYST---KQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 MK+A Y DK+ Q + E+ + L ++ K + + + + Sbjct: 1 MKMARYRVHVNDPLDKEATQLLMSKDELEVT-SEHLEKDELMKIIPEIDVLVVRSATKVT 59 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 ++E K +K IA G +N+D+ AKE G+K++ P +VAE A+G+M+ Sbjct: 60 ADIIEAGK--NLKIIARAGIGLDNIDVQKAKEKGIKILNTPGASAPSVAELAMGLMLACA 117 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R I RA ++ + + L G + GKT G+IG G IG + + FGM+++A+DP Sbjct: 118 RHIARATISLKEGKWEKKALNGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDP-- 175 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + A +L VEYVDL TLF ESD ISLH PLT H++N + +MK+GV+IVNT+RG Sbjct: 176 AKPATDLPVEYVDLDTLFRESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGT 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID +A EAL + K+ + G+DV+E E D++ R+L NV+ T H Sbjct: 236 IDEEALYEALVSGKVYAAGLDVFEVEPP-----------TDEIRRKLLNLDNVVATPHIG 284 Query: 298 FLTAEALTSISQTTLQNL 315 T EA + ++ + Sbjct: 285 ASTDEAQNRVGTELVEKI 302 >UniRef50_A5VLZ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=19 Tax=Lactobacillus RepID=A5VLZ7_LACRD Length = 330 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 107/330 (32%), Positives = 175/330 (53%), Gaps = 4/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDD-GSRP 59 MKL +YS + +K Y++ + G +++ L T K A G + + + G Sbjct: 1 MKLIMYSVRDAEKPYIEAWEKKTGNDVKMVTEPLNADTVKLAEGYDGISLQQTTKLGDEQ 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + E+L G+K +A R G + DLDA K G+ V VP Y P A+AE + M L RR Sbjct: 61 LYEQLAAMGIKQLAARMVGVDIFDLDACKANGIIVTNVPIYSPRAIAEMGVTQAMYLLRR 120 Query: 120 IHRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 I QR +F + L +Y T G++G G IG A +I K G ++LA+DP + Sbjct: 121 IGEFEQRMSHGDFRWSDDLISNEIYNLTVGIVGLGNIGGATAQIYKALGAKVLAYDPSYN 180 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 E VEY D T+ +D++SLH PL P +++ F+ MK+ ++N +RG L+ Sbjct: 181 -VEYEPYVEYTDFDTVIKNADILSLHTPLLPSTENMIAAPQFKMMKDNAYLINMARGKLV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ I AL+N++I G+D +E F + ++D I DD +++L+A NVL T H AF Sbjct: 240 NTADLISALENKEIAGAGLDTLADETSFFGKQVTSDQIPDD-YKKLAAMPNVLVTPHVAF 298 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 LT ++ ++ + +L + + +G+ NE+ Sbjct: 299 LTETSIRNMVEISLNDAVTILEGKHSRNEI 328 >UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms RepID=GYAR_THEON Length = 334 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 90/337 (26%), Positives = 158/337 (46%), Gaps = 25/337 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFEL-EFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK V T++ + ++ + E F E+ E + E + +A+ +++ Sbjct: 1 MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V + + +K +A G++N+D++ A ++G+ + P A A+ A +++ RR Sbjct: 61 VFDAAPR--LKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARR 118 Query: 120 IHRAYQRTRDANFSLEG-------LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 + A + R + G G+ +YG+T G++G G+IG A+ R KGFGMR+L Sbjct: 119 LIEADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILY 178 Query: 173 FDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVN 231 ELG E++ L L ESD + L PLT E YH++NE + MK ++VN Sbjct: 179 NSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVN 238 Query: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVL 291 +RG ++D++A ++AL+ I G+DV+E E L + NV+ Sbjct: 239 IARGKVVDTEALVKALREGWIAGAGLDVFEEEPYYH--------------EELFSLDNVV 284 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T A +++ +NL + GE P + Sbjct: 285 LAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTLV 321 >UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTC6_TRIAD Length = 520 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 86/321 (26%), Positives = 150/321 (46%), Gaps = 18/321 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D K + V E+ G E+ L + + + + + V++ Sbjct: 6 KVLISDSVDPK-CKSVLEAKGIEVTLNTKLSPAELVAEIPNYDGLIVRSATKVTAEVIKA 64 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K +K I G +N+D+ AA E G+ V+ P + + AEH +M+ L R++ +A Sbjct: 65 GK--NLKIIGRAGTGVDNIDIKAATECGVIVMNTPGGNTLSAAEHTCTLMVCLARQVPQA 122 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 R+ + + G + GKT G+IG G+IG + ++ FG+R + +DP P+ AA Sbjct: 123 AASMREGRWDRKKYMGIELMGKTLGIIGLGRIGREVATRMQSFGVRTVGYDPIVPAEAAK 182 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E VE+ +L L+ E D I++H PL P+ LL + F + K GV ++N +RG +ID A Sbjct: 183 EFDVEFFELNDLWPECDFITVHTPLIPQTRGLLGDETFAKCKKGVRVINCARGGIIDEAA 242 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + AL++ + +DV+E E E L NV+ H T E Sbjct: 243 LLRALQSGQCAGAALDVFEQEPPQNTE--------------LVQHPNVIPVCHLGASTVE 288 Query: 303 ALTSISQTTLQNLSNLEKGET 323 A + ++ + + +G++ Sbjct: 289 AQSRVAVEIAEQFVDFNEGKS 309 >UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquificales RepID=B2V7I1_SULSY Length = 529 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 149/321 (46%), Gaps = 16/321 (4%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V T K L+ ++ +L++ + + + +A+ ++ +LE Sbjct: 3 KVLVTDDISPKGLEILSNDEEIDLDYQPEIKFNELLEIIKDYDAIITRSRTPVTKELLER 62 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K +K I G +NVDL+ A G+ VV P + AE + + + R++H A Sbjct: 63 AEK--LKVIGRAGVGVDNVDLEEASRRGILVVNTPGANTIGAAEITMAHLYAVLRKLHLA 120 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 + + + G + GK G+IG G +G + K G +++A+DPY P Sbjct: 121 HDSVKAGEWKRSKFMGEELDGKVVGIIGLGNVGSQVAIRCKAAGAKVIAYDPYIPKEKGD 180 Query: 183 ELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LGVE + DL L SD+I+LHCPLT E +++ + F+ MK GV +N +RG ++D Sbjct: 181 RLGVEIIDDLHELIKISDIITLHCPLTEETRNMIGKKEFDLMKKGVYFINCARGGIVDED 240 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A++ KI LG+DV+ E D+ RRL N+ + H T Sbjct: 241 ALYDAIQEGKIAGLGLDVFSKEPP------------DERIRRLFEFPNISLSPHIGANTY 288 Query: 302 EALTSISQTTLQNLSNLEKGE 322 E+ +++ Q + KG+ Sbjct: 289 ESQDNVAIKIAQYVIAALKGQ 309 >UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MG73_RHOM4 Length = 322 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 98/336 (29%), Positives = 165/336 (49%), Gaps = 28/336 (8%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFD----FLLTEK-TAKTANGCEAVCIFVNDDGSRP 59 + T+ ++ L+ + E+ G ++E D L E + A +A+ +D + Sbjct: 4 IVVTRPVMEEGLRPLFEN-GHQVEILDPDPEHPLDEDALIEAAREADALITMPSDPVTAR 62 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VLE K ++ +A G+ N+DL+AA+ G+ V P +A A+ +++ L RR Sbjct: 63 VLENCPK--LRIVAQHAVGYENIDLEAARARGIVVTHTPGVLTDATADFTFALLLALVRR 120 Query: 120 IHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 + A + R+ +F L G + K G++G G+IG A+ R GFGMR++ ++ Sbjct: 121 VREADRYVREGHFKRWETKLLLGHDLRDKVLGIVGLGRIGSAVARRALGFGMRVVYYNRR 180 Query: 177 PSAAALELG--VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 P+ +E YV L SDVIS+HCPL E+YHL + AAF +MK ++VNT+R Sbjct: 181 PANPTIERQSCARYVSFDELLRTSDVISIHCPLNKESYHLFDRAAFAKMKPTAVLVNTAR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D +A +EAL+ +I +DV+E+E + L V+ Sbjct: 241 GPIVDEEALVEALEQGQIAGAALDVFEHEPRVHP--------------ALLRSDRVVLAP 286 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKG-ETCPNELV 329 H T EA T++++ + + + G E P LV Sbjct: 287 HLGSATVEARTAMARACAEAVLAVLNGEEKIPYRLV 322 >UniRef50_A6LTK2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=15 Tax=Bacteria RepID=A6LTK2_CLOB8 Length = 327 Score = 365 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 103/328 (31%), Positives = 198/328 (60%), Gaps = 3/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ YS ++ + +Y ++ ++ + E+ + + +TA A G + + I + + + + Sbjct: 1 MRILAYSHRRDETQYFEEFSKKYNVEVVLCNEEPSLETAPLAKGFDCISI-ITTNINSEL 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + + + GVK+I+ R G++++DL AKELG++V V Y P +VA++ I +++ R++ Sbjct: 60 VGKFHELGVKFISTRTIGYDHIDLKKAKELGVRVGNV-TYSPNSVADYTIMLILMAVRKV 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R+ +FSL G+ G + T GV+GTGKIG +++ L GFG ++LA D Y + Sbjct: 119 KLIMERSNVQDFSLRGIQGKELPNLTIGVVGTGKIGRTVIKHLSGFGCKILAHDIYENDE 178 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ++ +YVDL LF SD+I+LH P T +NYH++N+ A + MK+GV I+NT+RG+LI++ Sbjct: 179 -VKSNAKYVDLENLFKYSDIITLHMPATDDNYHIINKKAIKLMKDGVFIINTARGSLINT 237 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 I ++++KIG +DV E E ++++ D + +++ L + NV+ T H AF T Sbjct: 238 NDLIHGIESKKIGGAALDVIEQESNIYYSDLKGEALKNRNLAILKSFPNVIITPHAAFYT 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +A++ + + ++++ + + P E+ Sbjct: 298 DQAVSDMIENSIKSCILFSENKENPWEI 325 >UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Bacteria RepID=Q2RH37_MOOTA Length = 329 Score = 365 bits (939), Expect = e-99, Method: Composition-based stats. Identities = 107/332 (32%), Positives = 160/332 (48%), Gaps = 21/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRPV 60 K VY T+ + L + E E+ D +LT + + G + + + D V Sbjct: 3 KWNVYVTRLVPQPALDLLAEYCDLEINPEDRVLTRAELLEKVRGRDGILCLLTDILDDEV 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 K G K A GFNNVDL+AA G+ + P EA A+ A ++ + RR+ Sbjct: 63 FTAAK--GAKIFANLAVGFNNVDLEAATRHGIMITNTPGVLTEATADMAWALLFAVARRV 120 Query: 121 HRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + TR + G + G + GKT GVIG G+IG A R +GF M++L D P Sbjct: 121 VEGDKFTRAGKYKGWGPLLMLGQEITGKTLGVIGAGRIGTAFARKARGFDMKVLYHDVQP 180 Query: 178 SAAALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 S A E G ++VD TL E+D +SLH PL P HL++ + MK +++NTSRG Sbjct: 181 SKAFEEATGGQFVDKETLLKEADFVSLHVPLMPSTTHLISTPELKLMKKTAILINTSRGP 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D +A ++AL+ ++I G+DV+ENE +L L+ NV+ H Sbjct: 241 VVDEKALVKALREKEIWGAGLDVFENEPELAPG--------------LADLENVVLCPHI 286 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 A T E T+++ NL +GE P L Sbjct: 287 ASATWETRTNMALMAANNLLAALRGELPPQCL 318 >UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actinobacteria (class) RepID=Q1AXS3_RUBXD Length = 527 Score = 365 bits (939), Expect = 1e-99, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 151/330 (45%), Gaps = 22/330 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ V T++ ++ ++ + FE++ L + + + + + + V Sbjct: 1 MRVLV--TEKLAERGVELLRRE--FEVDVLLGLSPGELLERIGEYDGLIVRSATKVTAEV 56 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E + +K I G +N+D++AA + G+ V P + A AEH +G+M+ + RRI Sbjct: 57 IEAAGR--LKAIGRAGIGVDNIDIEAATKRGILVANAPESNTVAAAEHTLGLMLAVARRI 114 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A R ++ G + KT G++G G +G + R G GMR+LA+DPY S Sbjct: 115 PAADASLRRGEWNRAAFKGVEVAEKTLGLVGLGHVGSIVARGALGMGMRVLAYDPYVSEE 174 Query: 181 ALE-LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 + + VE L +F E+D +SLH P TP+ ++ E +MK ++N +RG ++ Sbjct: 175 RMRSMNVERAGSLEEIFEEADFVSLHVPRTPQTTGMVGEEELARMKPTAYLINVARGGIV 234 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D A ALK +I +DV+ E L A NV+ T H Sbjct: 235 DETALYNALKQGEIAGAALDVFAEEPTTD--------------SPLFALPNVVVTPHLGA 280 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA T + ++ +GE + + Sbjct: 281 STAEAQDRAGVTAAEQVAAALRGEVPIHAI 310 >UniRef50_C4Z227 D-lactate dehydrogenase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z227_EUBE2 Length = 328 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 120/330 (36%), Positives = 199/330 (60%), Gaps = 5/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIF-VNDDGSRP 59 MK+A +S +Q +K+Y + EL+ T ++ GCEA+ + D S P Sbjct: 1 MKIAAFSVRQDEKQYFDTFANVYKVELQINRSGFTADDIESVKGCEAMSVCDGMCDLSAP 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VLE+L GVKYI R G+N+VDL+AAK LG++V Y P +VA + + +M+ R+ Sbjct: 61 VLEKLAAEGVKYIGFRTIGYNSVDLEAAKRLGIRVAHS-GYSPYSVANYTVMLMLMCIRK 119 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 R+ A++SL + G M T G+IGTG+IG A+++ L GFG +++A+DPYP+ Sbjct: 120 ALYVMMRSHTADYSLGPICGREMQNMTVGIIGTGRIGKAVIKNLSGFGCKIIAYDPYPAK 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 VEYV L L++ +D+ISLH L+ E YH++N+ + +MK+GV+++N +RGAL+D Sbjct: 180 DLE--NVEYVTLDELYARADIISLHTFLSDETYHMINKDSIAKMKDGVILINAARGALVD 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFED-KSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ IEA+++ KIGS+G D E E + D K +D++ + + L + N + T H AF Sbjct: 238 TKDLIEAVESGKIGSVGTDCCEGEDEFIRTDRKYDDLVVNHDYIILKSFQNTIVTPHVAF 297 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T +A++ + +++++++ GE P E+ Sbjct: 298 FTDQAVSDMVESSVKSVVQFAAGEDTPLEV 327 >UniRef50_B5HCN2 D-lactate dehydrogenase n=6 Tax=Streptomyces RepID=B5HCN2_STRPR Length = 335 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 142/329 (43%), Positives = 188/329 (57%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + +K +++ + D L TA A G E + VN V Sbjct: 1 MEILAFGVQADEKPLIEKAFADLPGGVRCLDVFLDADTAAIAAGHEVISTSVNAQLDAEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L G + IA R GFNN+DL+ A+ LGL V RV Y P +VAE A + M +NRR+ Sbjct: 61 LRTLAVGGTRMIAQRSTGFNNIDLEVAERLGLTVARVSYYSPYSVAEFAWTLTMAVNRRV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA RTRD +F L+GL G M G+TAGVIGTGKIG A RI GFGMRLL D P+ Sbjct: 121 VRAANRTRDFDFRLDGLMGRDMRGRTAGVIGTGKIGEAFTRIAHGFGMRLLGLDVAPNPV 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +ELG+EYVD L + +D++SLH PL P HL+ MK+ ++VN+SRG LIDS Sbjct: 181 CVELGMEYVDKDELLAAADLVSLHVPLMPATRHLIGARELRAMKDDAILVNSSRGGLIDS 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + L+ + +G+DVYE E LFF DKS + + DD RL NVL T HQA+ T Sbjct: 241 DALVGELRKGRFSGVGLDVYEAEAGLFFLDKSMEAVDDDTLARLMTFPNVLVTSHQAYYT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 A+A+T I TT +N+ +G N LV Sbjct: 301 ADAVTQIVDTTARNIKAHLEGRRGENVLV 329 >UniRef50_O66939 D-lactate dehydrogenase n=1 Tax=Aquifex aeolicus RepID=O66939_AQUAE Length = 334 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 166/324 (51%), Gaps = 7/324 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + S Q D + Q+ + ++ D + E + +FV D + + Sbjct: 1 MNVLFTSVPQEDVPFYQEALKDLSLKIYTTDVSKVPEN--ELKKAELISVFVYDKLTEEL 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L ++ + +K I R GF+++DLD K+ G+ V +PAY PE+VAEH M++TL +R+ Sbjct: 59 LSKMPR--LKLIHTRSVGFDHIDLDYCKKKGILVTHIPAYSPESVAEHTFAMILTLVKRL 116 Query: 121 HRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 R R + NFS + + + T GVIGTG+IG + FGM++L +D Sbjct: 117 KRIEDRVKKLNFSQDSEILARELNRLTLGVIGTGRIGSRVAMYGLAFGMKVLCYDVVKRE 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E G Y L L ESDVISLH P T E +H++NE MK+GV ++NT+RG ++D Sbjct: 177 DLKEKGCVYTSLDELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFR--RLSACHNVLFTGHQA 297 + A A + K LG+DV+E+E L + + D + L+ NV+ T H A Sbjct: 237 TDALYRAYQRGKFSGLGLDVFEDEEILILKKYTEGKATDKNLKILELACKDNVIITPHIA 296 Query: 298 FLTAEALTSISQTTLQNLSNLEKG 321 + T ++L I + T++ + KG Sbjct: 297 YYTDKSLERIREETVKVVKAFVKG 320 >UniRef50_A4S3N1 Predicted protein n=2 Tax=Ostreococcus RepID=A4S3N1_OSTLU Length = 380 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 143/337 (42%), Positives = 206/337 (61%), Gaps = 16/337 (4%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + V+S +Y+ + L++ + + L+ TA A G +AVC+FV+DD V+ Sbjct: 40 RCFVFSAHRYEDETLRRALPNA----TYSSARLSLDTASLAQGHDAVCVFVDDDARGEVV 95 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + L + GVK I LRCAGF+NVD + A+E G+ V+RVPAYDP +++EHA+ MMM+LNR + Sbjct: 96 DALAERGVKLILLRCAGFDNVDCERARERGISVLRVPAYDPLSISEHAVAMMMSLNRHLC 155 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAA 180 + R R NF+L+GL G +M GKT GV+GTGKIG + ILK GF MR+L +D + Sbjct: 156 ASRDRLRMGNFTLDGLVGSSMRGKTVGVVGTGKIGRGVAEILKNGFQMRVLGYDKFEKDD 215 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +YV L L + SDV+SLH PLTPE ++ +MK G +++NTSRG L+D+ Sbjct: 216 FCG---DYVSLDELLARSDVVSLHLPLTPETRGMICVETIAKMKEGTILINTSRGLLVDA 272 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSN------DVIQDDVFRRLSACHNVLFTG 294 +AAI+ L + +I +LG+DVYENE LFF+D S+ ++ D+ L + VL T Sbjct: 273 RAAIDGLYSGRIAALGLDVYENENRLFFKDFSSMNTNERMLVWDETMAILGSMPQVLVTP 332 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCP--NELV 329 H AFLT EAL I++ T +N GE N +V Sbjct: 333 HTAFLTHEALDEIAKHTAENFRQFCAGERLEGANVVV 369 >UniRef50_D2W085 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W085_NAEGR Length = 388 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 158/329 (48%), Positives = 220/329 (66%), Gaps = 7/329 (2%) Query: 7 STKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL-K 65 S Y Y + ++ S F L+F D LTE T + A + V +FVND +R VL+ L Sbjct: 59 SPYDYLPNYERFMSYSGPFHLKFVDARLTESTVELAEHSDFVSVFVNDCLNRNVLQTLSH 118 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 K+G+K +ALR AGFNNVDL AA E G+KV RVP Y P A A+ I ++M LNR+IH+A+ Sbjct: 119 KYGIKCVALRSAGFNNVDLSAASEFGVKVCRVPEYSPAATADFTIALIMALNRKIHKAFN 178 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIG-TGKIGVAMLRILK-GFGMRLLAFDPYPSAAALE 183 R RD++FSL+GL GF M K G++G +GKIG + + L+ GFG R++ +D Y + Sbjct: 179 RLRDSDFSLDGLMGFNMSSKVFGIVGGSGKIGKLVAKCLRMGFGARVIVYDSYRDPELVN 238 Query: 184 LGVEYVD-LPTLFSESDVISLHCPLTPE-NYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +G+E+VD + ++++ SDVI LHCPL HL+N + +MK+GVMI+NTSRG L + Sbjct: 239 MGIEFVDNIDSIYAHSDVICLHCPLIKGVTEHLINSESISKMKDGVMIINTSRGGLCRTD 298 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 IE LK+QKIGSLG+DVYE E+DLFFED+ ++I+DD F RL NV+ T HQAF T Sbjct: 299 DLIEGLKSQKIGSLGIDVYEFEQDLFFEDRRFEIIKDDTFTRLLTFPNVIVTPHQAFFTQ 358 Query: 302 EALTSISQTTLQNLSNL-EKGE-TCPNEL 328 EA+++I+QTTL++L + G+ PN L Sbjct: 359 EAISNIAQTTLESLYSFDISGQIKQPNVL 387 >UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JIG3_9ARCH Length = 542 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 88/326 (26%), Positives = 156/326 (47%), Gaps = 19/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V T ++ ++++ E ++E L E A +A+ I ++ +++ Sbjct: 12 KVLVTDNISEEGIKKLREFGDVDVEL--DLSKEDLAACIANYDALVIRSGTTVTKEIIDA 69 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K+ +K I G +N+D++ A E G+ VV P + + AEH M+++++R+I A Sbjct: 70 GKR--LKVIGRAGVGVDNIDVERATEKGILVVNSPEANSISAAEHTFAMLLSISRKIPAA 127 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 + + + G + GK G IG G++G + + KGFGMR++A DP+ SAA A Sbjct: 128 NVSLKSGKWERKKHMGVEVNGKVLGTIGLGRVGSEVAKRAKGFGMRVVAHDPFISAAKAK 187 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ELG+ + + + +D I+LH PLT + +H++ + FE MK+GV ++N +RG ++D A Sbjct: 188 ELGITLLGFKEVLATADFITLHTPLTKDTHHMIGKGEFELMKDGVRVINCARGGILDEDA 247 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 EA+K K+ +DV+E E + L V+ T H T E Sbjct: 248 LKEAIKAGKVAGAALDVFEQEPPNNDD--------------LLELEEVIVTPHLGASTTE 293 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A + + + + N L Sbjct: 294 AQRAAAVVIADEVIGALSNKPVKNAL 319 >UniRef50_C9NGL5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=7 Tax=Streptomyces RepID=C9NGL5_9ACTO Length = 334 Score = 363 bits (934), Expect = 4e-99, Method: Composition-based stats. Identities = 141/329 (42%), Positives = 195/329 (59%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + +K +++ ++ D LTE TA A G E V VN D V Sbjct: 1 MEILAFGVQSDEKPLIEKAFAGL-HDVRCLDVFLTEDTAPIAAGYEIVSTSVNADLGSRV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L G + IA R GFNN+DLD A+ L L+V RV Y P +VAE A + M +NRRI Sbjct: 60 LQTLAAGGTQMIAQRSTGFNNIDLDVAERLALRVARVSYYSPYSVAEFAWTLAMAVNRRI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA RTRD +F L+GL G M+G+TAGV+GTGKIG A RI GFGM LL +D + A Sbjct: 120 VRAVSRTRDFDFRLDGLLGRDMHGRTAGVLGTGKIGEAFARIAHGFGMNLLGWDVAENPA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG+ YVD L +E+D+ISLH PL P HL++E A MK+ ++VN+SRG L+D+ Sbjct: 180 CTALGMTYVDKEQLLAEADLISLHVPLLPATQHLIDERALSAMKDDAILVNSSRGGLVDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A + L+ + +G+DVYE E LF+ DKS + I DD RL NV+ T HQA+ T Sbjct: 240 RALVGELRAGRFTGVGLDVYEAEAGLFYVDKSVEGIDDDTLARLVTFPNVIVTSHQAYYT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 +A+ I T++N+++ G N LV Sbjct: 300 RDAVGQIIDATVRNVTDYLAGRRSDNVLV 328 >UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verrucomicrobia RepID=B4D991_9BACT Length = 530 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 149/329 (45%), Gaps = 17/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V +K + ++ ++ L ++ A+ + + V+ Sbjct: 3 KPKVLVADPIAQKGIDELANGGSLDVTVKIGLKPDELLAIIGEFNALVVRSETKANAKVI 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E +K I G +NVD+DAA + G+ V+ P + + AEHA +M++ R I Sbjct: 63 EAA--TNLKVIGRAGVGVDNVDVDAATKRGIIVMNTPGGNTISTAEHAFSLMVSTARNIP 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A + + + G +Y KT ++G G+IG + R FGMR+LA+DPY SA+ Sbjct: 121 QADASVKSGKWDRKTFVGVELYNKTLAILGMGRIGTEIARRAIAFGMRVLAYDPYLSASR 180 Query: 181 ALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A L VE V L + ++D I+LH PLT E ++LN + K GV IVN +RG LID Sbjct: 181 ARSLQVELVESLDLIIPQADFITLHMPLTAETKYMLNAERLAKTKKGVRIVNCARGGLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A +EALK++++ + +DV+E E L N++ T H Sbjct: 241 EAALVEALKSKQVAAAALDVFEAEPL-------------PAESPLRGLPNLILTPHLGAS 287 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA + + + N + Sbjct: 288 TAEAQEGVGIEVAEQIRAALLSGEIRNAV 316 >UniRef50_Q0SVM3 D-lactate dehydrogenase n=31 Tax=Bacteria RepID=Q0SVM3_CLOPS Length = 332 Score = 363 bits (932), Expect = 5e-99, Method: Composition-based stats. Identities = 116/331 (35%), Positives = 188/331 (56%), Gaps = 4/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +KL Y ++ + Y ++NE FG++L + L + + A G EA+ + N R Sbjct: 2 IKLVCYGVRETEVPYFHKLNEEFGYDLTLVEKNLNHENVEEAIGAEAIMVRGNCMADRQN 61 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE LK G+KY+ R GF++VDL+AAK+LGL+V RVP Y P A+ E A+ + M L R Sbjct: 62 LELLKSKGLKYVLTRTVGFDHVDLEAAKDLGLQVARVPGYSPNAIGELAVSLAMMLLRHT 121 Query: 121 HRAYQRTRDANFSLEGLT-GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 RT + NF ++G + T G++G G+IG+ ++ KG G +++A+D + S Sbjct: 122 AYTTHRTSNKNFVVDGFMFSKEIRNCTVGILGAGRIGLTTAKLFKGLGAKVVAYDVFQSD 181 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA E+ VE++ L + SDVIS+H P +NYH++NE +MKN +I+NT+RG L Sbjct: 182 AAKEI-VEFMPLDEVLKVSDVISVHMPYIKGQNYHMINEEFISKMKNDAIIINTARGELQ 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC-HNVLFTGHQA 297 D +A ++AL+ ++G G DV E E +FF++ ++++ + +L + L T H Sbjct: 241 DIEAIVKALEEGRLGGFGTDVLEGESAVFFKNLEGQKLENESYEKLISLYPRALVTPHMG 300 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EAL ++ + +NL + TC N + Sbjct: 301 SYTDEALRNMIGISYENLKEYLEKNTCKNAI 331 >UniRef50_P17584 D-2-hydroxyisocaproate dehydrogenase n=9 Tax=Lactobacillus RepID=DHD2_LACPA Length = 333 Score = 362 bits (931), Expect = 7e-99, Method: Composition-based stats. Identities = 107/326 (32%), Positives = 180/326 (55%), Gaps = 3/326 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ Y + + +Y +Q + G LE+ L E T + A G + + + V Sbjct: 1 MKIIAYGARVDEIQYFKQWAKDTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E++ +G+K++ +R G +N+D+ A K+ G+++ VPAY P A+AE A+ + L R + Sbjct: 61 FEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNM 120 Query: 121 HRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + + + ++ G G + +T GV+GTG IG +++ KGFG +++A+DPYP Sbjct: 121 GKVQAQLQAGDYEKAGTFIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +YV L LF +SDVI LH P +N H++NEAAF MK G +++NT+R LID Sbjct: 181 GDHP-DFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLID 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +QA + LK+ K+ +G+D YE E + + +D ++ L NV+ + H A+ Sbjct: 240 TQAMLSNLKSGKLAGVGIDTYEYETEDLLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYY 299 Query: 300 TAEALTSISQTTLQNLSNLE-KGETC 324 T A+ ++ +LQ+L + KGET Sbjct: 300 TETAVHNMVYFSLQHLVDFLTKGETS 325 >UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verrucomicrobiales RepID=B5JEX5_9BACT Length = 545 Score = 362 bits (930), Expect = 9e-99, Method: Composition-based stats. Identities = 96/332 (28%), Positives = 161/332 (48%), Gaps = 20/332 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK---TAKTANGCEAVCIFVNDDGS 57 MK+ V + + + + GFE+ E + A G A+ + + + Sbjct: 14 MKILV--ADKISSTGVDFLKQQEGFEVVEAYGTFKEDYSKFLELAKGAAAIIVRSDSKVT 71 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R V E + +K + G +N+D +AA + G+ V+ P + A AE M+ Sbjct: 72 REVFE-VAAPTLKAVGRAGVGVDNIDSEAATDFGVVVMNTPGGNTIATAELTFTHMLCGA 130 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R + +A Q R+ + + G ++ KT GV G G+IG + + K FGM++LA+DPY Sbjct: 131 RPVPQAAQSMREGRWDRKIYGGSELFKKTLGVCGMGRIGAEVAKRAKAFGMKVLAYDPYL 190 Query: 178 SAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 S A E +GVE V+L LF ESD I++H PLT ++++AA MK+GV + N +RG Sbjct: 191 SGAKAETMGVEQVELDELFRESDYITVHMPLTDATRGMIDDAAIATMKDGVRLFNCARGG 250 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID A + L++ K+ + G+DVY +E +D FR + T H Sbjct: 251 IIDEDALLRGLESGKVAAAGLDVYTSEPP----------AEDHPFRSQKTLN---LTPHL 297 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S+ ++++++ +G N + Sbjct: 298 GASTEEAQESVGLEIAESVTSVLRGGGIRNAI 329 >UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YAK7_DICT6 Length = 316 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 97/326 (29%), Positives = 162/326 (49%), Gaps = 25/326 (7%) Query: 9 KQYDK--KYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 + ++K ++V + G E+ F L E+ + + + + + D + VL+ Sbjct: 9 RSFEKIKDKFEEVFKEEGIEVMLNPFGRVLTEEEMRELIRDVDGLIVGI-DPVTSKVLKN 67 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K +K I+ G +N+D+ AK+ + V P + AVAE +G+++ + R+I+ + Sbjct: 68 ANK--LKVISKYGVGVDNIDILEAKKRNIVVTNTPGANSNAVAELTVGLIINVLRKINLS 125 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 ++TR+ + G + KT GVIGTG IG ++ +LKGF +R+L FD YP A Sbjct: 126 DKKTREGRWDR--FIGNELSEKTLGVIGTGSIGRRVIELLKGFNLRVLCFDKYPDYEWAS 183 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 + V YV L L SDV+S+H PLT E YH+++E MK +++NTSRG ++D A Sbjct: 184 KEKVFYVTLDELLRSSDVVSIHVPLTEETYHMISEKELRMMKKNAVLINTSRGGIVDEDA 243 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 LK +I G+DV+E E L NV+ T H T E Sbjct: 244 LYRFLKEGRISGAGLDVFEKEPPQN--------------SPLLQLDNVVVTSHIGAHTEE 289 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++++ ++NL KG + + Sbjct: 290 AVANMAKLAVENLLLALKGREPLSRV 315 >UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C430A3 Length = 540 Score = 362 bits (929), Expect = 1e-98, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 153/328 (46%), Gaps = 21/328 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K + + ++ L + E+ + + + E + +A+ + + +L Sbjct: 18 KYHILVSDAMSQEGLLPLLENAN--VHCVEAYVDE--VEDLTQFDALLVRSATKVTEELL 73 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +++ +K +A G +N+DLDAA + G+ VV P + + AEH M+ +L R+I Sbjct: 74 QKMP--NLKIVARAGVGVDNIDLDAATKHGVVVVNAPDGNTISTAEHTFAMISSLLRKIP 131 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A + ++ + G + GKT G++G G+IG + + + F M LL FDP+ + A Sbjct: 132 QANASIKAGEWNRKAFQGSELRGKTLGIVGFGRIGTQIAKRARAFEMSLLVFDPFLTKAR 191 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A ++GV L + ++SD+I++H PLT E +L + K GV ++N +RG +ID Sbjct: 192 AEKIGVTPASLDDVLAQSDIITVHTPLTKETKGILGMENIAKTKQGVFLINCARGGIIDE 251 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A L N I +DV+E E + L NV+ T H A T Sbjct: 252 SALKHYLANGHIAGAALDVFEEEPAQD--------------KELLEFDNVIATPHIAAST 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + + +G+ N + Sbjct: 298 KEAQLNVASQVSEEVIRFLEGQPATNSI 325 >UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMX1_SYNFM Length = 525 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 145/329 (44%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + L + + G +++ D E+ +AV + + + Sbjct: 1 MKVLI--CDGMHEVGLSILRAAEGIDVDVPDQPGAEEIKAMLPDYDAVIVRSRTRITAEL 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E + +K I G +N+D+ AA G V+ P + A AEH I MM+ L R I Sbjct: 59 IENAPR--LKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALARHI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A Q R+ + + G ++ +T G+IG GKIG + M +L DPY Sbjct: 117 PQATQSMREGRWDKKRFMGTELFHQTLGIIGLGKIGSIVADRALSMKMDVLGHDPYIIPE 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGVE+V L L + SD ++LH P T E +LN + K GV I+N +RG LID Sbjct: 177 AAAILGVEWVPLDELLARSDFLTLHTPSTSETVRILNRETLARTKPGVRILNCARGGLID 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA E L N +G +DV+E E V L NV+FT H Sbjct: 237 EQALYEFLLNGHVGGAALDVFEQEP--------------PVDSPLLKLENVIFTPHLGAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 + +A ++++ + + N + Sbjct: 283 SYQAQANVARAIATQIVDYLLYGIIRNAV 311 >UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=1 Tax=Chironex fleckeri RepID=D1FX73_CHIFL Length = 520 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 80/320 (25%), Positives = 144/320 (45%), Gaps = 16/320 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + D + + + ES +++ + E+ + + + + V Sbjct: 9 VLISDKVD-EVCKTIFESNKINVDYRPGISKEELLAIIKDYDCLVVRSATKVTAEVFSAA 67 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K + G +N+DL AA G+ V+ P + + AEH MM +L R I + Y Sbjct: 68 P--NLKLVGRAGTGVDNIDLKAATNNGVFVMNTPGGNTMSAAEHTCAMMFSLARHIPQGY 125 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALE 183 ++ + G + GKT G+IG G+IG + ++ MR + +DP P AA E Sbjct: 126 MSMQEGKWERSKFMGCELKGKTLGIIGLGRIGKEVALRMQACEMRTVGYDPIVPKEAAAE 185 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 GVE+++L ++ D I++H PL P+ L+N F++ K + ++N +RG +ID Sbjct: 186 FGVEFMELEEMWPIVDFITVHTPLIPQTKGLVNAKTFDKCKKTIRVINVARGGIIDESDL 245 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 ++AL K G+DV+ +E V L V+ T H TAEA Sbjct: 246 LDALNAGKCAGAGLDVFSSEPPSG------------VVSELVKHPRVVCTPHLGASTAEA 293 Query: 304 LTSISQTTLQNLSNLEKGET 323 +++ + + + G+T Sbjct: 294 QVRVAKEIAEQIVDACNGKT 313 >UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thermoanaerobacter italicus Ab9 RepID=C6PIV3_9THEO Length = 325 Score = 360 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 90/312 (28%), Positives = 151/312 (48%), Gaps = 18/312 (5%) Query: 17 QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 +++ E G E+ + E EA+ + ++ ++E K +K I+ Sbjct: 15 RKILEEKGIEIITAPDVKEETLISMVRDVEAIIVRSKAKITKGIIENAPK--LKIISRTG 72 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS-LE 135 AG +N+D++AA E G+ V +PA + +VAEH I M++ L +++ Q R+ N+ Sbjct: 73 AGVDNIDVNAATEKGILVCNLPAVNSLSVAEHTIAMILHLAKQLSLMDQAVRNGNWEMRN 132 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAAALELGVEYVD-LPT 193 + GKT G++G G IG+ + + G GM+++A+DPY + +VD L Sbjct: 133 SNISVEVEGKTLGIVGMGNIGILVAKKCHDGLGMKIVAYDPYVKEKFKDYDYRFVDSLEE 192 Query: 194 LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIG 253 LF ESD ++LHCP PE ++ MK ++N +RG +ID QA IEALK ++I Sbjct: 193 LFKESDFVTLHCPDIPETRGMITRELIYSMKPTAYLINVARGTVIDEQALIEALKEKRIA 252 Query: 254 SLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQ 313 G+DV++ E L NV+ + H A LT EA ++ +Q Sbjct: 253 GAGLDVFQQEPPSRDN-------------ELLRLENVILSPHSAALTKEATVRMAVEAVQ 299 Query: 314 NLSNLEKGETCP 325 + + +G Sbjct: 300 AVIDYFEGRQPK 311 >UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41AB7 Length = 524 Score = 360 bits (924), Expect = 6e-98, Method: Composition-based stats. Identities = 97/328 (29%), Positives = 156/328 (47%), Gaps = 20/328 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + ++K ++ + E ++ + E+ +T +A+ I V+E Sbjct: 1 MKALVADAINEKGIENLKEVCDVVVDT--SITPEELLETIGEYDAILIRSRTKLPAEVIE 58 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K IA G +NVD++AA + G+ VV P VAEH +G++++ R+I Sbjct: 59 --KADNLKIIARAGVGVDNVDVNAATKKGIMVVNAPESTSITVAEHTMGLILSTIRKIAI 116 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAA 181 A + T+ + + G + KT GVIG G+IG ++ K F M +A+DPY P A Sbjct: 117 ADKSTKAGKWEKKAFMGMELRNKTLGVIGMGRIGSQVVNRCKAFEMDAIAYDPYLPPEVA 176 Query: 182 LELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +GVE Y D+ + + +D+I++H PLTPE H ++ F+ MK+ +I N +RG +ID Sbjct: 177 KNMGVELYEDIEDVLTRADIITIHVPLTPETEHSISTEQFKMMKDTALIFNCARGGVIDE 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A EAL N +I G+DVYE E +L N++ T H A T Sbjct: 237 DALYEALVNGEILGAGLDVYEKEPATN--------------NKLFELDNIVCTPHIAAST 282 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA + + L KG N + Sbjct: 283 KEAQRDAAIIVANEVITLFKGGMPKNII 310 >UniRef50_C0GGJ9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGJ9_9FIRM Length = 335 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 107/336 (31%), Positives = 177/336 (52%), Gaps = 14/336 (4%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + + T+ D+ + + L F + L++K + E + +F+ + +L Sbjct: 3 NITFFETQTGDRPAFETALK--DHSLSFTEEPLSDKNIADFSDSEIISVFIYSHATAELL 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +L +K I R +GFN++DL AA E + V VP Y VAEHA +++TL+R I+ Sbjct: 61 SQLP--NLKLILTRSSGFNHIDLKAATERNIPVCNVPVYGENTVAEHAFALILTLSRNIY 118 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 +AY RT+ +FSL+GL GF + KT V+G G+IG+ +++I + F M++LA DP P Sbjct: 119 KAYLRTQREDFSLKGLQGFDLKDKTLAVVGAGRIGLHVIKIARSFNMKVLAVDPTPDPFL 178 Query: 182 LE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E L Y L + + +D+ISLH PL + +HLLN+ +K G +++NT+RG L+++ Sbjct: 179 AEVLQFSYAPLEEVLTRADIISLHAPLNEKTHHLLNKENISTIKKGALLINTARGELVET 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVF-------RRLSACHNVLFT 293 A + AL + I G+DV E+E ++K L +V+ T Sbjct: 239 DALLAALNDGTIAGAGLDVLESEELFVEDEKLFSPHTPPETLTTVLKNHILLNREDVVIT 298 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H F + EA+ I +TT+QN++ G P +V Sbjct: 299 PHIGFNSKEAVHRIRETTVQNITAFLAG--SPENVV 332 >UniRef50_D1PMF0 D-lactate dehydrogenase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PMF0_9FIRM Length = 328 Score = 359 bits (922), Expect = 1e-97, Method: Composition-based stats. Identities = 119/329 (36%), Positives = 194/329 (58%), Gaps = 4/329 (1%) Query: 1 MKLAVYSTKQYDK-KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ Y+ + +D+ +Y + E +G + ++ + + T + + A GC+AV + Sbjct: 1 MKILFYALRPFDELQYCEPNREKYGIDYKWTEEVPTPENLQLAEGCDAVST-NPCEVRPE 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 LE K GVKY+ R G++++ LDAAK LGL+V Y PE VA + I +M+ R+ Sbjct: 60 YLEAFAKMGVKYLPCRSIGYDHIPLDAAKRLGLRVSHS-HYPPEGVANYTIMLMLMATRK 118 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +++ R ++SL G G + T GVIGTGKIG ++R L GFG ++LA+D YPS Sbjct: 119 MNQIMVRAAAQDYSLPGKMGHDLSSCTVGVIGTGKIGSTVIRHLSGFGCKILAYDLYPSD 178 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A EYV L L++ SDVI+LH TPEN+HL+N A +MK+GV++VNT+RG LID Sbjct: 179 AVRPY-AEYVSLNELYARSDVITLHLNATPENHHLINAEAITRMKDGVLLVNTARGTLID 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S++ ++ L++ KIG G+DV E+E + + ++ + + + L + NV+ + H AF Sbjct: 238 SESLLQGLESGKIGGAGLDVVEDENGICYYNRCGEALPNRELNLLRSYPNVILSPHTAFY 297 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T + S+ Q+ + +++ G + P E+ Sbjct: 298 TDVNVASMVQSAFEAVADFAAGRSNPCEV 326 >UniRef50_O83080 D-lactate dehydrogenase n=2 Tax=Treponema pallidum RepID=LDHD_TREPA Length = 331 Score = 358 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 106/330 (32%), Positives = 179/330 (54%), Gaps = 3/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M+ V++ ++ + Y+++ +S G ++ ++ LT K + G E + + Sbjct: 1 MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V + + +K ++ R AGF+ + K+ G+++ VP+Y P A+ E+A+ + L R Sbjct: 61 VYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRH 120 Query: 120 IHRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 R +F + + + G++GTG+IG A R+ KG G +++ FDPYP+ Sbjct: 121 AREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPN 180 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA E + YV + L S SDVISLH P T +++HL+N QMK+GV +VNT+RGA+I Sbjct: 181 DAAKEW-LTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVI 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 DSQA +++L KI +D YE E +D N+ I D V+ RL A +++T H AF Sbjct: 240 DSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAF 299 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ ++ +L + + +GE C E+ Sbjct: 300 YTETAIENMVFNSLDACTTVLRGEPCAAEI 329 >UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A5G1V9_ACICJ Length = 528 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 89/316 (28%), Positives = 143/316 (45%), Gaps = 17/316 (5%) Query: 14 KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIA 73 + + G ++ L + + + + I +R +L+ +K I Sbjct: 12 PAAIDIFKRRGIDVTVKTGLAPAELREIIGEFDGLAIRSATKVTRELLDAA--TNLKVIG 69 Query: 74 LRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS 133 G +NVD+ +A G+ V+ P + AEHAIG+M L R + A T+ + Sbjct: 70 RAGIGVDNVDVKSATARGVVVMNTPYGNAITTAEHAIGLMFALARELPEASASTKAGKWE 129 Query: 134 LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLP 192 G + GKT G+IG G IG + G MR+LA+DPY + A A LGVE DL Sbjct: 130 KNRFMGVELTGKTLGLIGAGNIGSIVADRALGLKMRVLAYDPYLTEARATTLGVEKADLD 189 Query: 193 TLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKI 252 T+ + +D I+LH PLT + ++L+ + + K GV I+N +RG L+D A +ALK+ + Sbjct: 190 TVLARADFITLHTPLTEQTRNILSRESIARTKPGVRIINCARGGLVDEAALYDALKSGHV 249 Query: 253 GSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTL 312 +DV+E E L A NV+ T H T EA +++ Sbjct: 250 AGAALDVFEVEPAKE--------------SPLFALPNVVCTPHLGAATTEAQENVALQVA 295 Query: 313 QNLSNLEKGETCPNEL 328 + +S+ N + Sbjct: 296 EQISDFLLTGAVTNAI 311 >UniRef50_C1DWX6 Glyoxylate reductase (Glycolate reductase) n=6 Tax=Aquificales RepID=C1DWX6_SULAA Length = 342 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 101/339 (29%), Positives = 180/339 (53%), Gaps = 14/339 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELE--FFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK+ + + +++ YL++ + G +++ F L + + +F+ ++ Sbjct: 1 MKVHFFEVEDWERLYLEKKIKDMGLDVDLGFTKEPLDDTNVDLYKDIDVAIVFIYSKLNK 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 VL ++ +K I R G++++D++ + G+ V VP Y VAE+ +++ L R Sbjct: 61 DVLSKM--QNLKLIITRSTGYDHIDVEYTSKNGITVCNVPGYGNNTVAEYTFALILALAR 118 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + +RT FS +GLTG + GKT GVIG G+IG ++RI GFGM++L +D Y Sbjct: 119 KFKPMIERTSKGIFSRDGLTGIDLMGKTIGVIGAGRIGKHVIRIAYGFGMKILVYDRYKD 178 Query: 179 AAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 ++ G EYV L L SD+++LH P +HL+N+ + MK M++NTSRG + Sbjct: 179 QELIDKYGAEYVGLEDLLRMSDIVTLHVPYNKSTHHLINKFNIKLMKLDAMLINTSRGPV 238 Query: 238 IDSQAAIEALKNQKIG-SLGMDVYENERDLFFED--KSNDVIQDDVFRRLSAC-----HN 289 ++ +A ++ALK ++ +G+D +E E L E+ K +D+ + + L + N Sbjct: 239 VEMEAIVQALKEGRLAGGVGLDTFEAEEVLIEEEYLKRDDIPAIKLKKALESFYVLHSEN 298 Query: 290 VLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 V+ + H A+ T +AL I TL NL + +G N++ Sbjct: 299 VIVSPHNAYNTKDALYRILDITLDNLKSYLEG-NPKNKV 336 >UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Euryarchaeota RepID=A6UQN3_METVS Length = 523 Score = 358 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 160/327 (48%), Gaps = 19/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 L + T + ++ + E+ E+E + E+ + +A+ + ++ +++ Sbjct: 2 LKILITDPLHESAIEILKEAG--EVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIID 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K IA G +NVDLDAA E G+ VV P +VAE G+M++ R I + Sbjct: 60 A--SENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQ 117 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAA 181 A + + + G +Y KT G++G G+IG + + + F M ++A+DPY P A Sbjct: 118 ATASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVA 177 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 ELG++ + + L +ES+ I+LH PLT + H++ + F+ MKN +I+N +RG LID Sbjct: 178 SELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDEN 237 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A+ K+ + G+DV+E E L + + ++ T HQ T Sbjct: 238 ALYDAINCGKVKAAGLDVFEEEPPTK--------------NPLISLNGLIGTPHQGASTE 283 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA S + + KGE+ N + Sbjct: 284 EAQLSAGTIVAEQTVKILKGESAENVV 310 >UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobacterium thermophilum RepID=Q67TJ9_SYMTH Length = 540 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 92/331 (27%), Positives = 153/331 (46%), Gaps = 24/331 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T+ + + + + ++ + +E+ + +A+ + V Sbjct: 1 MKILV--TEAISETGISLLRDEHEVDVR---KVTSEELLEIIPEYDALITRSETKVTAEV 55 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L + +K + G +N+D+ AA E G+ VV VP + + AEHA G+++ + R I Sbjct: 56 LARGTR--LKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVARNI 113 Query: 121 HRAYQRT-RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PS 178 +A+ R+ + G ++GKT G+IG G+IG + + FGMR+LA+DPY P Sbjct: 114 PQAHHALAREGRWDRMSFVGTELHGKTLGIIGLGRIGSEVAVRARAFGMRVLAYDPYVPH 173 Query: 179 AAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + A LGV V L L E D +++H TPE+ L+ A MK IVN +RG + Sbjct: 174 SRAEHLGVTLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTARIVNCARGGM 233 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D +A ALK ++ +DV+ E L NV+ T H + Sbjct: 234 VDEEALYRALKEGRLAGAALDVFAAEPCTD--------------SPLFGLPNVVVTPHLS 279 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA + + Q + +GE P + Sbjct: 280 ASTAEAQDANGRYIAQYVLRALRGELVPEAV 310 >UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyanobacteria RepID=SERA_SYNY3 Length = 554 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 155/326 (47%), Gaps = 19/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D+ + + + +++ L + +A+ + + +++ Sbjct: 31 KVLVSDSIDQVGIDILKQVA--QVDVKTGLSEAEIIDIVPEYDAIMLRSATKVTEKIIQA 88 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 + +K I G +N+D+ AA G+ VV P + A AEHA+ MMM L R I A Sbjct: 89 GSQ--LKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDA 146 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 + +++ + + G +Y KT GV+G GKIG + + K GM+LLA+DP+ S A Sbjct: 147 NKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERAD 206 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ++G VDL LFSE+D I+LH P TPE +L+N +MK I+N SRG +ID +A Sbjct: 207 QIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEA 266 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + A++ +IG +DV+ E RL NV+ T H T E Sbjct: 267 LVTAIETAQIGGAALDVFAQEPLGE--------------SRLREFSNVILTPHLGASTEE 312 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A +++ + + ++ G + + Sbjct: 313 AQVNVAVDVAEQIRDVLLGLPARSAV 338 >UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fragment) n=2 Tax=Coelomata RepID=B7P3M8_IXOSC Length = 473 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 79/312 (25%), Positives = 148/312 (47%), Gaps = 17/312 (5%) Query: 18 QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCA 77 ++ E+ G ++ + + G +A+ + + V++ + +K I Sbjct: 20 KILENNGVQVTLKTDFTKPELLQAIEGYDALIVRSATKVTSDVIKAGQA--LKVIGRAGT 77 Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 G +N+D DAA G+ V+ P + + AE M++TL+R I A + + + Sbjct: 78 GVDNIDCDAATRQGILVINAPGGNTLSAAELTCAMIVTLSREIPAATMSLKAGKWDRKTF 137 Query: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTLFS 196 G +YGKT ++G G+IG + ++ FGM+ + FDP P + E GVE + L ++ Sbjct: 138 MGNELYGKTLAIVGLGRIGKEVALRMQSFGMKTIGFDPIVPKEVSREFGVESMSLDEIWP 197 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 +D I++H PL P+ L+ +A+ ++ K GV I+N +RG +++ + AL++ G G Sbjct: 198 LADYITVHTPLIPQTKDLIGKASLQKCKKGVKIINVARGGIVNEDDLLAALESGHCGGAG 257 Query: 257 MDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLS 316 +DV+ E + L A V+ T H T EA ++Q + Sbjct: 258 LDVFLEEPPKNTQ--------------LIAHPKVVCTPHLGANTKEAQLRVAQEIAEQFV 303 Query: 317 NLEKGETCPNEL 328 +L +G++ P + Sbjct: 304 DLSQGKSVPGVV 315 >UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonellaceae RepID=C4V410_9FIRM Length = 565 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 81/302 (26%), Positives = 137/302 (45%), Gaps = 16/302 (5%) Query: 24 GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVD 83 +E++ D + E+ +A+ + + VLE K +K I G +N+D Sbjct: 58 DYEVDVRDKISHEELLDVIGDYDALMVRSASKVTADVLERAGK--LKIIGRAGVGVDNID 115 Query: 84 LDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMY 143 + AA E G+ V+ P + A EH + MM+ + R I A ++ + G + Sbjct: 116 VKAATERGIIVINSPGGNTIAATEHTVAMMLAMARNIPTADATMHAGQWNRKAYVGVELR 175 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVIS 202 GKT GVIG G+IG + + F M ++A+DPY + A LGV L + ++D I+ Sbjct: 176 GKTLGVIGMGRIGGGVAKRALAFDMNVIAYDPYINEERAKALGVTVGTLDDIIEQADFIT 235 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 +H PLT E +++ A +MK GV +VN +RG +I+ EA++ + +DV+E+ Sbjct: 236 VHMPLTKETRGMISMAQMRRMKQGVRLVNCARGGIINEHDLAEAVREGIVAGAAIDVFES 295 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 E L + ++ T H T EA +S + + +GE Sbjct: 296 EPLAEDSP-------------LRSVPGIVLTPHLGASTVEAQIGVSVDVAKGICAALRGE 342 Query: 323 TC 324 Sbjct: 343 PV 344 >UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Deltaproteobacteria RepID=A8ZXY9_DESOH Length = 532 Score = 357 bits (917), Expect = 4e-97, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 150/329 (45%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V + D + ++ GF ++ L E+ +A+ I + + Sbjct: 1 MTMKVLVSDTIDASGVSRLENESGFAVDVKTGLPPEELKSIIGQYDALIIRSATKVTADI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE +K +A G +NVD+ AA + G+ V+ P + AEH I MMM L R I Sbjct: 61 LEA-GAPKLKAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + R + + L G ++ KT GVIG GKIG + + M ++ FDP + Sbjct: 120 PQGTLSLRSGQWEKKKLQGREVFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIART 179 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +E G EYV L LF+ +D I++H P + LLN+AAFE+MK GVM++N +RG ++D Sbjct: 180 TIENEGFEYVSLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +AL + ++ + +DV+ E L NV+ T H Sbjct: 240 EADLYDALMSGRVAAAALDVFVTEPPGE--------------HPLLKLDNVIATPHLGAS 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++++ + K T N + Sbjct: 286 TKEAQVNVAEAAAHQIIEFLKNNTVINAV 314 >UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clostridia RepID=B0TAQ8_HELMI Length = 526 Score = 356 bits (915), Expect = 6e-97, Method: Composition-based stats. Identities = 88/325 (27%), Positives = 154/325 (47%), Gaps = 19/325 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ V +K + + + ++ L ++ + +AV + ++ + Sbjct: 1 MRVLV--CDPISQKGIDVLTSAGDVAVDVKLKLTEDQIVEIIAEYDAVVVRSETKITKRI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E + +K I G +N+D++AA G+ VV P + A AE + ++ + R + Sbjct: 59 IEAADR--LKAIGRAGVGVDNIDVEAATRKGIVVVNAPEGNTIAAAELTVAHILAIARNV 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-A 179 A + + TG + GKT G++G GKIG + + + F M ++A+DPY S Sbjct: 117 GSANLSLKGGKWDRSKYTGIELKGKTLGILGLGKIGSEVAKRARAFDMTVIAYDPYASVE 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGV DL T+F +SD I++H P T + Y +++ A F MK GV IVN +RG +ID Sbjct: 177 KAKSLGVTVTDLETVFRQSDFITVHMPKTKDTYRMISAAQFAIMKEGVRIVNCARGGIID 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA +A+++ K+ + G+DV+E E L A V T H Sbjct: 237 EQALYDAIQSGKVAAAGLDVFEKEPCTD--------------SPLFALDQVTATPHLGAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETC 324 T EA +++ ++ + +GE Sbjct: 283 TKEAQVNVAIDVAYDILRVLRGEAV 307 >UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C9V4_9PLAN Length = 541 Score = 356 bits (915), Expect = 7e-97, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 148/326 (45%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T L+ + ++ E++ L E+ + + + I + VL+ Sbjct: 4 VLITDNLSPAGLKILEDNPEIEVDIRSGLSPEEVREALKSADGIIIRSATKLTEEVLKGQ 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K I G +N+D AA G+ V+ PA + + AE I +MM L R I AY Sbjct: 64 PR--LKAIVRAGVGVDNIDRAAATREGIVVMNTPAGNTTSTAEQTIALMMALARNIGPAY 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 ++ + + LTG + GKT +IG G+IG+++ +G M+++ +DP+ SA A E Sbjct: 122 ATMKEGKWERKKLTGTQVAGKTLAIIGLGRIGLSVAHRAQGLEMKVIGYDPFMSAERAAE 181 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 G+E Y ++ L D +++H PLT E L+N M+ GV I+N +RG +++ Sbjct: 182 YGIELYKEVDELVKHCDFLTVHTPLTDETRDLINAERIATMRPGVRIINCARGGIVNEDD 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +AL++ K+ DV+ E RRL N+L T H T E Sbjct: 242 LADALESGKVAGAACDVFTQEPPEN--------------RRLIDAPNMLATPHLGASTDE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + +S+ + + Sbjct: 288 AQEMVALEAAEIISDFLTKNEIRHAI 313 >UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cellular organisms RepID=Q2G4V7_NOVAD Length = 540 Score = 356 bits (914), Expect = 7e-97, Method: Composition-based stats. Identities = 90/328 (27%), Positives = 149/328 (45%), Gaps = 18/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V + + D + E G +++ E+ + + I + ++ +L Sbjct: 15 KPKVLISDKMDPNAARIFTE-MGCDVDVITGETPEQLIARIGEYDGLAIRSSTKVTKAIL 73 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + +K I G +NVD+ AA G+ V+ P + AEHAI MM L R+I Sbjct: 74 DAA--TNLKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIP 131 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 A +T+ + G G + GKT G+IG G IG + G M+++AFDP+ + Sbjct: 132 EANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKVVAFDPFLTPER 191 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+E+GVE DL TL +++D I+LH PLT + ++L+ + K GV I+N +RG L+D Sbjct: 192 AVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRIINCARGGLVDE 251 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A +AL + + +DV+E E L N + T H T Sbjct: 252 AALKDALDSGHVAGAALDVFETEPAKE--------------SPLFGTPNFICTPHLGAST 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + +++ N L Sbjct: 298 TEAQVNVALQVAEQMADFLVTGGVTNAL 325 >UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacillaceae RepID=Q5WGX7_BACSK Length = 533 Score = 356 bits (914), Expect = 7e-97, Method: Composition-based stats. Identities = 84/325 (25%), Positives = 145/325 (44%), Gaps = 21/325 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + ++ L + E+ E+ + A +A+ I + +L + Sbjct: 14 ILVADTMSEEGLLPLLEADHVEVT----QASVDNAGPLEQYDALLIRSATTVTEELLSRM 69 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K +A G +NVD+ AA + G+ V+ P + + AEH MM L R I +A Sbjct: 70 PR--LKIVARAGVGVDNVDIQAATKHGVVVINAPDGNTISTAEHTFAMMCALLRNIPQAN 127 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + + + G + GKT G++G G+IG + + K F M +L +DP+ +A A + Sbjct: 128 ASVKSGKWDRKAYQGTELRGKTLGIVGFGRIGTQLAKRAKAFEMGVLVYDPFLTAERAEK 187 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LG+ +L + S +D+I++H PLT + LLN + K GV ++N +RG +ID QA Sbjct: 188 LGIAQGELDHVLSVADIITVHTPLTKDTKGLLNMETIAKTKPGVFLINCARGGIIDEQAL 247 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 L N + +DV+ E + L +V+ T H A T EA Sbjct: 248 KHYLNNGHVAGAALDVFTEEPATD--------------KELIGHPSVVATPHIAASTKEA 293 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ Q + GE N + Sbjct: 294 QLNVAAQVSQEVLQFLNGEPALNSI 318 >UniRef50_Q59642 D-lactate dehydrogenase n=5 Tax=Lactobacillaceae RepID=LDHD_PEDAC Length = 331 Score = 356 bits (914), Expect = 8e-97, Method: Composition-based stats. Identities = 105/328 (32%), Positives = 175/328 (53%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ Y + +K YL + E++ LL A + V + + + Sbjct: 1 MKIIAYGIRDDEKPYLDEWVTKNHIEVKAVPDLLDSSNIDLAKDYDGVVAYQQKPYTADL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +++ + G+ +LR G +NV DA K+ +K+ VPAY P A+AE ++ ++ L R+I Sbjct: 61 FDKMHEFGIHAFSLRNVGLDNVPADALKKNDIKISNVPAYSPRAIAELSVTQLLALLRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + ++ E G + T GVIGTG+IG A + I K FG +++A+D + + A Sbjct: 121 PEFEYKMAHGDYRWEPDIGLELNQMTVGVIGTGRIGRAAIDIFKPFGAKVIAYDVFRNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + G+ L L+ +++VI+LH P +NYH+L+E AF QM++G I+N +RG L+D+ Sbjct: 181 LEKEGMYVDTLEELYQQANVITLHVPALKDNYHMLDEKAFGQMQDGTFILNFARGTLVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A ++AL + K+ +D YENE +F D + I D VF L + NV+ T H AF T Sbjct: 241 PALLKALDSGKVAGAALDTYENEVGIFDVDHGDQPIDDPVFNDLMSRRNVMITPHAAFYT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++ Q L N +L + + NE+ Sbjct: 301 RPAVKNMVQIALDNNRDLIEKNSSKNEV 328 >UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Thermomicrobia (class) RepID=B9L167_THERP Length = 745 Score = 355 bits (913), Expect = 9e-97, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 153/328 (46%), Gaps = 21/328 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 ++ V D++ +++ ++ D + +A+ + +R +L Sbjct: 203 RIVVSDV--IDQRARERLASEA--DVIEVDGRDKPALYEALREADALIVRSETQVTRELL 258 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + ++ +A G +N+DL AA E G+ V+ P + + EH + +M+ + R + Sbjct: 259 AHAPR--LRVVARAGTGVDNIDLQAATEAGILVLNAPGANAVSAGEHTVALMLAIARNLI 316 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 A T + + F + GKT G++G G++G + + L+ F RLL +DPY + Sbjct: 317 DANATTHAGRWERKRFRPFDLKGKTIGIVGLGRVGSVVAQRLRAFECRLLGYDPYITRER 376 Query: 182 -LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +LGVE VD TL SD+++ H P TPE H+L+ A +MK G +++N +RG ++D Sbjct: 377 FAQLGVEPVDYETLLENSDIVTFHVPATPETRHMLDARAIARMKPGAIVINCARGEVVDV 436 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QA EALK+ + + G+DV+ E L NV+ T H + Sbjct: 437 QALAEALKSGHLAAAGVDVFPEEPAYQ--------------SPLFGLPNVVLTPHIGGSS 482 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL ++ + +GE PN + Sbjct: 483 REALEAVGEIIATTTLAALRGEIVPNAV 510 >UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A7HDB1_ANADF Length = 528 Score = 355 bits (913), Expect = 9e-97, Method: Composition-based stats. Identities = 90/325 (27%), Positives = 160/325 (49%), Gaps = 17/325 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + ++ + E+ G E++ L ++ + + + + + +L++ Sbjct: 5 VLVSDDLSPEAVRILQEA-GLEVDVKVGLKPDQLERIVGDYDGLAVRSATKVTAQLLDKA 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K I G +NVDL AA G+ V+ P VAE A+ M++ L+R + A Sbjct: 64 AR--LKVIGRAGVGVDNVDLAAATRRGVVVMNTPGGSSITVAELALSMILALSRHVAAAT 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + + + G + G+T GV+G G IG ++ GMR++AFDP+ SA A + Sbjct: 122 GSVKAGKWEKKRFQGHELAGRTLGVVGIGNIGSVLVARAVALGMRVVAFDPFISAEAAAK 181 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LG VDL TL+ E+DV+S+H PLT + HL++ A +MK G ++VN +RG ++D +A Sbjct: 182 LGASLVDLDTLWREADVVSIHVPLTDKTRHLVDATALGKMKKGALLVNCARGGIVDERAL 241 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +AL++ ++G G+DV+E E L NV+ T H T EA Sbjct: 242 ADALRSGQLGGAGLDVFEQEPP-------------PADHPLYGLENVILTPHIGASTEEA 288 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 ++++ + L++ N + Sbjct: 289 QSAVAVAVAEQLADYLVRGVVRNAV 313 >UniRef50_A0Q8P3 D-isomer specific 2-hydroxyacid dehydrogenase n=5 Tax=Francisella novicida RepID=A0Q8P3_FRATN Length = 327 Score = 355 bits (913), Expect = 1e-96, Method: Composition-based stats. Identities = 163/329 (49%), Positives = 227/329 (68%), Gaps = 3/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ YSTK+YDK Y E+ +LEF ++ L ++TA A G +AVCIFVND V Sbjct: 1 MKILFYSTKKYDKTYF--TAENNQHDLEFKEYGLNQQTADFAKGYDAVCIFVNDICDADV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++L GV+ + LRCAGFNNVD+D AK+L +KV RVPAY P +VAEH + +++ LNR+I Sbjct: 59 LDKLYSLGVRAVLLRCAGFNNVDIDHAKKLDIKVARVPAYSPFSVAEHTLALLLCLNRKI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R +++NF++EGL GF ++ KT G+IG G IG A +I GFG +L +DPY A Sbjct: 119 HKAYNRVKESNFNIEGLEGFDVHRKTIGIIGFGNIGKAFAQICSGFGGEILVYDPYADRA 178 Query: 181 ALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V +V D LF+E+D+ISLHCPL + ++++E A + +K I+NTSRGALID Sbjct: 179 IAPSYVTFVDDKNKLFAEADIISLHCPLNADTKYIIDEKALQIIKPSTFIINTSRGALID 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +QA I++LK++ I +L +DVYE E+DLFF+D S ++I DD+F RL NVL T HQAFL Sbjct: 239 TQAIIKSLKSKSIAALAIDVYEYEKDLFFKDMSGEIINDDLFERLLTFPNVLVTAHQAFL 298 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EAL I+ TTL N S +E+ ++ N + Sbjct: 299 TKEALEGIATTTLDNASMIEQSKSSDNLV 327 >UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cellular organisms RepID=A7IAB7_METB6 Length = 534 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 83/302 (27%), Positives = 144/302 (47%), Gaps = 17/302 (5%) Query: 25 FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDL 84 F ++ L ++ +A+ + + + V+ KK +++I G +NVD+ Sbjct: 24 FTVDVKTDLKEDELCGVIGEYDALIVRSGTEVTAKVITAGKK--LRFIGRAGVGVDNVDV 81 Query: 85 DAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYG 144 DAA G+ V P + A EH + MM++L R I +A + + G + Sbjct: 82 DAATRQGVIVANAPEGNTLAATEHTMAMMLSLARNIPQANASLKKKEWKRSKFMGVELNE 141 Query: 145 KTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISL 203 KT G++G G+IG + + M+ +A+DP+ S A +LGV + L LF+ +DVI++ Sbjct: 142 KTLGIVGFGRIGREVAKRANAMDMKCVAYDPFISKERAAQLGVRVMSLAELFTVADVITV 201 Query: 204 HCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 H PL E H++N + MK+GV I+N +RG +ID A ++A+K+ K+ +DV+E E Sbjct: 202 HTPLIKETKHVINAKSIATMKDGVRIINCARGGIIDEAALVDAIKSGKVAGAALDVFETE 261 Query: 264 RDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGET 323 L L + NV+ T H T EA +++ + + G + Sbjct: 262 PPLE--------------SPLLSLDNVIVTPHLGASTVEAQKNVAIQVAKQCVEVLNGGS 307 Query: 324 CP 325 Sbjct: 308 AK 309 >UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bilateria RepID=SERA_HUMAN Length = 533 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 81/323 (25%), Positives = 146/323 (45%), Gaps = 20/323 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + + +++ + G ++ L E+ CE + + + V+ Sbjct: 8 KVLISDSLD---PCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVI 64 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +K ++ + G +NVDL+AA G+ V+ P + + AE GM+M L R+I Sbjct: 65 NAAEK--LQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIP 122 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A +D + + G + GKT G++G G+IG + ++ FGM+ + +DP S Sbjct: 123 QATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEV 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + GV+ + L ++ D I++H PL P LLN+ F Q K GV +VN +RG ++D Sbjct: 183 SASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDE 242 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + AL++ + +DV+ E R L NV+ H T Sbjct: 243 GALLRALQSGQCAGAALDVFTEEPPRD--------------RALVDHENVISCPHLGAST 288 Query: 301 AEALTSISQTTLQNLSNLEKGET 323 EA + + ++ KG++ Sbjct: 289 KEAQSRCGEEIAVQFVDMVKGKS 311 >UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staphylococcus RepID=Q4L766_STAHJ Length = 532 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 156/329 (47%), Gaps = 17/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + LQ + F ++ L + E + + ++ V Sbjct: 1 MKHNILVSDPISTDGLQSLLNHSDFNVDIKTDLDEQSLLDIIGDYEGLIVRSQTQVTQQV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +K IA G +N+D+DAA G+ V+ P + + EH++ M++ + R I Sbjct: 61 IE--KASNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNTISATEHSVAMILAMARNI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+ ++ ++ + G +Y KT GVIG G+IG+ + + L+ FGM++LA+DPY + Sbjct: 119 PQAHASLKNKEWNRKAFKGVELYQKTLGVIGAGRIGIGVAQRLQSFGMKVLAYDPYLTED 178 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +LGV+ + + ++D +++H PLTP+ ++N F + K + I+N +RG +I+ Sbjct: 179 KAQQLGVKLATIDEIARQADFVTVHTPLTPKTRGIVNADFFSKAKPTLQIINVARGGIIN 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + AL N +I +DV+E+E L ++ T H Sbjct: 239 EDDLLNALNNNQIARAALDVFEHEPPTD--------------SPLIEHDKIIVTPHLGAS 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ + + + ++ + + + Sbjct: 285 TIEAQEKVAVSVSEEIIDILENGNVTHAV 313 >UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPS0_9BACT Length = 318 Score = 353 bits (908), Expect = 3e-96, Method: Composition-based stats. Identities = 86/330 (26%), Positives = 150/330 (45%), Gaps = 20/330 (6%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTA-KTANGCEAVCIFVNDDGSRPVLE 62 VY + + L +N + D + K + + V + + + Sbjct: 3 KVYVCHKIPEAGLNLLNGKVEYRCWDGDGPVPRDLLLKEISDVDGVITMLTEKVDSEFFD 62 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 VK ++ G+NNVD++ A G+K+ P EA A+ A G+++ +RR Sbjct: 63 NAP--NVKVVSNYAVGYNNVDVEEATSRGVKITNTPGVLTEATADIAFGLLVAASRRFTE 120 Query: 123 AYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 A + R ++ L G ++GKT G+IG G+IG A+ R GFGM+++ P Sbjct: 121 AERYLRSGKWTCWHPTMLLGREIFGKTLGLIGFGRIGKAVARRASGFGMKVIYHTPSGGP 180 Query: 180 AALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A + G +V + +SD +SLHCPL L+ + E+MK ++VNTSRG ++ Sbjct: 181 ATDQGDGPRWVSFEEILEKSDYLSLHCPLNDRTRGLIGKKELERMKPDAVLVNTSRGPVV 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D + E+L++ IG+ G+DVY+ E + L + NV+ H Sbjct: 241 DQTSLYESLRDGVIGAAGLDVYDEEPISLEDP-------------LLSLENVVMLPHIGS 287 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ N+ ++ +G+ N + Sbjct: 288 ATREARDAMATMAASNMLDVLEGKEPRNPV 317 >UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=A2STQ1_METLZ Length = 527 Score = 353 bits (908), Expect = 3e-96, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 145/304 (47%), Gaps = 17/304 (5%) Query: 26 ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLD 85 E++ L ++ K +A+ + + ++E K +KYI G +N+D + Sbjct: 24 EVDEKADLSEDELVKIIGEYDALIVRSGTQVTARIIEAADK--MKYIGRAGVGVDNIDCE 81 Query: 86 AAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGK 145 AA + G+ V P + A EH I MMM + R I +A + + G M GK Sbjct: 82 AATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNIPQASASLKKGEWKRSKFMGNEMNGK 141 Query: 146 TAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTLFSESDVISLH 204 GV+G G+IG + + + M ++A+DP+ P+ +GVE + + LF+++DVI++H Sbjct: 142 VLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAEVGAAMGVEMMSVAELFTKADVITVH 201 Query: 205 CPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENER 264 PL P HL+N+ + MK GV ++N +RG +ID + +A+ + K+ +DV+E E Sbjct: 202 TPLIPSTTHLVNKESIATMKTGVRMINCARGGIIDEKDLYDAIVSGKVAGAALDVFETEP 261 Query: 265 DLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 L +V+ T H T EA +++ + ++ KG + Sbjct: 262 PTE--------------SPLLKLDSVIVTPHLGASTVEAQKNVAISVAHQCIDVLKGGSA 307 Query: 325 PNEL 328 + + Sbjct: 308 KSAV 311 >UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (PGDH) n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZY1_9BACT Length = 535 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 76/323 (23%), Positives = 146/323 (45%), Gaps = 18/323 (5%) Query: 8 TKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKH 67 ++ ++ G E+ L + C+ V + N + PVLE K Sbjct: 14 IADDLPDVCNEILQNAGVEVLKKTGLKPPELDAVIKMCDGVIVRSNTKLTAPVLE--KSE 71 Query: 68 GVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRT 127 +K I G +N+D+ AA + G+ V+ PA + + AEH I ++ +L+R + +A Sbjct: 72 KLKAICRAGVGVDNIDVPAATKKGIVVMNTPAGNIISTAEHTIALLCSLSRFVPQACASV 131 Query: 128 RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGV 186 ++ + + TG + GKT G+IG G++G + + M+++ +DP+ + + + + Sbjct: 132 KEGKWEKKKFTGQQLTGKTFGIIGLGRVGRQVAKRAAALEMKVIGYDPFITTEISSQYNI 191 Query: 187 EYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIE 245 V +L L +++D I++H L E +L+ F MK GV I+N +RG +I + Sbjct: 192 HIVKNLRDLLAQADYITIHVTLNKETKNLITSKEFSLMKKGVQIINCARGGVICEEDLYN 251 Query: 246 ALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALT 305 A+K ++ +DV+E E +L V+ T H T EA Sbjct: 252 AIKTGQVAGAALDVFEEEPPKD--------------NKLLQLEEVIATPHLGASTEEAQY 297 Query: 306 SISQTTLQNLSNLEKGETCPNEL 328 +++ + ++ G+ N + Sbjct: 298 AVAIEAAEQMAAALTGKGYKNAV 320 >UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Acidovorax RepID=A1W9A3_ACISJ Length = 339 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 109/332 (32%), Positives = 171/332 (51%), Gaps = 10/332 (3%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + D+ +QQ + L + E +C+FV VL Sbjct: 9 VLFTDFAPTDQAAMQQRLPAHWHAHFVQREHLVASDTEDGA-IEVLCVFVRTRVDESVLR 67 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 L + ++ +A R AGF+++DL+A ++ G+ V VP Y +VAEHA +++ + R + + Sbjct: 68 MLPR--LRLVATRSAGFDHIDLEACRKRGIAVCHVPDYGSASVAEHAFALLLGVTRHLTQ 125 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAAA 181 A++R R +F+ GLTGF + G+T G++G G+IG + RI GFGM +LA+DP + ++AA Sbjct: 126 AHERARQGSFAYRGLTGFELEGRTLGIVGLGRIGRHVARIAVGFGMDVLAYDPAFAASAA 185 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 GV V + SD++SLH P T HL++ AF +MK GV+++NT+RGALID Sbjct: 186 RPAGVSLVTWEQVLQGSDILSLHVPATEATRHLIDARAFARMKPGVVVINTARGALIDEA 245 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSN-DVIQDDV----FRRLSACHNVLFTGHQ 296 A + AL + + + G+DV E E L E + + D L VL T H Sbjct: 246 ALLRALDDGSVAAAGLDVLEQEGALSPEVPTGCGGLGCDTGWMASSPLLTHPRVLVTPHV 305 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T EA+ I T+ N++ G N + Sbjct: 306 GFNTTEAIARIFDETISNIAAWHAGR-LRNRV 336 >UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Thermoanaerobacter RepID=B0K2Z0_THEPX Length = 324 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 90/330 (27%), Positives = 152/330 (46%), Gaps = 25/330 (7%) Query: 1 MKLAVYS--TKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK + S +K L+ FE+ + +A+ + +R Sbjct: 1 MKKVLLSEEIHPEGRKLLE-----GKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITR 55 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V+E +K I+ AG +N+D++AA E G+ V +PA + +VAEH I M++ L++ Sbjct: 56 EVIENAPH--LKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLSK 113 Query: 119 RIHRAYQRTRDANF-SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPY 176 ++ + R N+ + + GK G++G G IG + + G GM+++A+DPY Sbjct: 114 QLSLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMKIVAYDPY 173 Query: 177 PSAAALELGVEYVDL-PTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 ++VD LF ESD ++LHCP PE ++ MK+ ++N +RG Sbjct: 174 VKEKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARG 233 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +ID QA IEALK ++I G+DV++ E L NV+ + H Sbjct: 234 TVIDEQALIEALKEKRIAGAGLDVFQQEPPSSDN-------------ELLRLENVILSPH 280 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCP 325 A LT EA ++ +Q + + +G Sbjct: 281 SAALTKEATVRMAVEAVQAVIDYFEGRQPK 310 >UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Bacillales RepID=Q49YF7_STAS1 Length = 538 Score = 353 bits (906), Expect = 7e-96, Method: Composition-based stats. Identities = 84/326 (25%), Positives = 156/326 (47%), Gaps = 17/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 + + + L+ + + FE+ L + +A+ + + ++E Sbjct: 3 KILVSDPISPEGLKSLIDHNDFEVVIDTELDEAELINQIADYQALIVRSQTQVTEAIIEA 62 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K IA G +N+D+DAA + G+ V+ P + + EH++ M++++ R I +A Sbjct: 63 AP--NLKVIARAGVGVDNIDVDAATKHGVIVINAPDGNTISATEHSMAMILSMARNIPQA 120 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 +Q +D + + G +Y KT GVIG G+IG+ + + + FGM +LAFDPY S A Sbjct: 121 HQSLKDGKWDRKTYRGTELYNKTLGVIGAGRIGLGVAKRAQSFGMHILAFDPYLSEDKAK 180 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 EL V + + +SD +++H PLTP+ ++ +A FE+ K + I+N +RG +ID A Sbjct: 181 ELNVTRATVEEIAEQSDFVTVHTPLTPKTKGIVGKAFFEKAKPNLQIINVARGGIIDEAA 240 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 ++AL +I S +DV+E+E L ++ T H T E Sbjct: 241 LVDALNQNQIQSAAIDVFESEPATE--------------SPLVNHEKIIVTPHLGASTVE 286 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + + ++ + N + Sbjct: 287 AQEKVAVSVANEIVDIFENGNVFNAI 312 >UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina RepID=Q46AE6_METBF Length = 323 Score = 352 bits (905), Expect = 7e-96, Method: Composition-based stats. Identities = 100/330 (30%), Positives = 166/330 (50%), Gaps = 19/330 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V + ++Y ++++ ++ E+ + V + + Sbjct: 1 MKIVVSDSIFLPEEYRKKLDALGDLKVFESMPSSIEEFISRVRDADIVLVGRYGFSGKAF 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ +++ G++++DL AA E G+ V VP Y ++VAE + + L R++ Sbjct: 61 N---ASRNLQMLSVWQTGYDHIDLKAATEKGVIVSNVPDYAFDSVAEMVFALALNLLRKV 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H A R R+ NF G + GKT GVIGTG IG +++I GF M +++ +PS Sbjct: 118 HVADIRLREGNFDWRHYFGSQIMGKTMGVIGTGSIGSRVIQIAHGFNMNVISVTGHPSEE 177 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGV++VDL TL +E+D+++LH PLTP ++ +MK +++NT+RG ++D Sbjct: 178 KARSLGVKFVDLDTLLAEADIVTLHVPLTPSTEKMIGAKELAKMKKSAILINTARGKVVD 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A IEALK +KI G+DV+E E L A NV+ T H AFL Sbjct: 238 EAALIEALKEKKIRGAGLDVFEKEPL-------------PANDPLKALENVVLTPHIAFL 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T E+L + +QN+ +G+ P +V Sbjct: 285 TEESLEECTYVCVQNVERFIEGK--PQNIV 312 >UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YY17_METPS Length = 326 Score = 352 bits (905), Expect = 9e-96, Method: Composition-based stats. Identities = 110/336 (32%), Positives = 169/336 (50%), Gaps = 31/336 (9%) Query: 1 MKLAV----YSTKQYDKKYLQQVNESFGFELEFFDFLLT--EKTAKTANGCEAVCIFVND 54 MK+ + Y T +Y ++ E+ G +L +D + T E E + I Sbjct: 1 MKIVISEPIYLTDEY-----RRRLEALG-DLRAYDSVPTSDEDFVSRIKDAE-IVIAGRY 53 Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 S + G+K IAL G++NVDL AA G+ V V Y + VAE A + + Sbjct: 54 GFSGESIRRAP--GLKMIALWQTGYDNVDLAAATARGVVVSNVHNYAFDTVAEFAFALAL 111 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 L R++ +A R F G + GKT GVIG G IG +++I GF M +L+ Sbjct: 112 NLLRKVDKADLNLRRGLFDWRRYVGEELMGKTLGVIGLGSIGRRVVQIAHGFNMSVLSVT 171 Query: 175 PYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 +P A LGV++V L TL +ESDV+SLH PLTPE H++ A +MK +++NT+ Sbjct: 172 AHPDPERARALGVKFVSLDTLLAESDVVSLHVPLTPETEHMIGAAQLARMKPTAILINTA 231 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG ++D +A +EAL+ ++I G+DV+E E + L NV+ T Sbjct: 232 RGKIVDEKALVEALREKRIAGAGLDVFETEPL-------------PMDSPLLKLDNVVLT 278 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H AFL+ E++ ++ T++N+ KG P +V Sbjct: 279 PHIAFLSKESIDECTRVTMENVEMFVKGR--PQNVV 312 >UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CX87_HALOH Length = 527 Score = 352 bits (905), Expect = 9e-96, Method: Composition-based stats. Identities = 87/326 (26%), Positives = 154/326 (47%), Gaps = 17/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + K ++ + + ++ F L E+ + + + + + L+ Sbjct: 3 KVLVSDNISPKGIEILEQEA--DVTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALD- 59 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K +K I G++N+D++ A + G+ V P + + EH IGMM+ L+R I +A Sbjct: 60 -KARNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQA 118 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 Q + + + G + GKT G+IG G+IG + + FGM+++A DPY P A Sbjct: 119 NQALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAA 178 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ++ V + + +SD I+LH PLT E YH+L+ F MK+ V I+N +RG +D+QA Sbjct: 179 KINVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +AL K+ +DV+E E + +D+ L V+ T H T E Sbjct: 239 LAKALAEHKVAGAAIDVHEVEP----------LPEDNPL--LKYQDRVIMTCHLGGTTTE 286 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++S + + ++ + L Sbjct: 287 AMDNVSIAAAEQVLDVLNNGLPESPL 312 >UniRef50_C3WFC0 D-lactate dehydrogenase n=2 Tax=Bacteria RepID=C3WFC0_FUSMR Length = 328 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 124/330 (37%), Positives = 194/330 (58%), Gaps = 4/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL Y ++ +K + +++N+ FG++L + L+ ++ G +AV + N +R Sbjct: 1 MKLICYGVRKVEKPFFEKLNK-FGYDLTLVEELMNDENVNLIEGHQAVMLRANCPANRKN 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE++K GV+Y+ R G+N++DL+AA E+G K+ RVP Y P A+AE AI M L R+ Sbjct: 60 LEKMKNFGVEYLLTRTVGYNHIDLEAAYEMGFKMARVPRYSPNAIAELAITFAMNLVRKG 119 Query: 121 HRAYQRTRDANFSLEGLT-GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 R+R+ NF ++ + T GVIGTGKIG ++ KG G R++A+D YPS Sbjct: 120 AYMVDRSRNKNFIVDEYMFSPEIRNLTVGVIGTGKIGFTAAKLFKGLGARVIAYDLYPSE 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA E+ VEYV + L +D+I+LHCP EN +LL E +K+G +++NT+RG L Sbjct: 180 AAKEV-VEYVTMEELNKTADIITLHCPYIKGENDNLLGEEFISNLKDGAILINTARGELQ 238 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D +A I+ L++ KIG DV+ NE++ FF+D + I +V + +S VL T H Sbjct: 239 DVEAIIKGLESGKIGGFATDVFSNEKEFFFKDMAGKEIDKNVEKLISLYPRVLITPHIGS 298 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EALT++ + + +NL + C N+L Sbjct: 299 YTDEALTNMIEISYENLDEFLRTGDCQNKL 328 >UniRef50_B2UXX3 D-lactate dehydrogenase n=2 Tax=Clostridium RepID=B2UXX3_CLOBA Length = 328 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 116/318 (36%), Positives = 192/318 (60%), Gaps = 2/318 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++T+ +K + ++ +++ + LT +T A G + V + N D + V Sbjct: 1 MEIIAFATRPDEKAGFDKFSKELNIKVKNINERLTLETVHEARGFKFVSVLGNCDVNSEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L + GV+YIA R AG+NN+D+ AKELG+ + Y P+ VA+ A+ +M+ R++ Sbjct: 61 LEKLNEFGVEYIASRSAGYNNIDIKKAKELGIGISNA-NYSPKCVADFAVMLMLMCIRKV 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R R ++S+ GL G M+ GVIGTGKIG A+++ L GFG ++LA+D Y + + Sbjct: 120 VWGLERARVNDYSVIGLQGKEMHNLVVGVIGTGKIGQAVIKNLSGFGCKILAYDIYENES 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + V+YVD+ TL+ E D+I++H PL NY+L+N+ + +MK+GV+I+NTSRG LI++ Sbjct: 180 MKKY-VQYVDMDTLYKECDIITIHSPLFDSNYNLINKESMRKMKDGVVIINTSRGELINT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + IEAL K+G++G+DV ENE +F D + + L NV+ T H AF T Sbjct: 239 RDLIEALDKGKVGAVGLDVLENEVGIFHSDCRFTGVNNKDIIMLKQMKNVILTHHFAFYT 298 Query: 301 AEALTSISQTTLQNLSNL 318 +A+ + L++L Sbjct: 299 DQAVYDMVGCALKSLRAF 316 >UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EL38_9FIRM Length = 311 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 98/318 (30%), Positives = 157/318 (49%), Gaps = 18/318 (5%) Query: 11 YDKKY--LQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG 68 ++ KY ++ ++ GF++ L + + GC+A I D ++ +E LK Sbjct: 5 FEAKYDAFEERLKAAGFQVVRTGERLPAQIIECGKGCQAAVINAEDQWTKETMEGLKDT- 63 Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 + IA G +NVDLDAA+ LG+KV + E+VAE A+ +M+ RRI + R Sbjct: 64 LGLIARFGVGLDNVDLDAARGLGIKVANSAGANKESVAECAVTLMLECTRRISWLDGKLR 123 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVE 187 D + GKT G+IG G I + + KGFG ++LA D + AA L Sbjct: 124 DGQW-KGLPRTHQFSGKTVGLIGFGAIAQCVAGMAKGFGCKVLACDVIKNETAAKRLDTV 182 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 + ++ L +SD ISLH PLT + H+++EA ++MK +++NTSRG ++D +A AL Sbjct: 183 FCEMDELLEKSDFISLHVPLTEDTRHMVSEAFLKKMKPTAILINTSRGPVVDEKALYRAL 242 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K I + G+DV+E E L HN++ T H A T EA +I Sbjct: 243 KEGWIQAAGLDVFEQEPPGGDNP-------------LFGLHNIIVTPHAASSTEEAAGNI 289 Query: 308 SQTTLQNLSNLEKGETCP 325 + ++N+ + + Sbjct: 290 ADLCMENICSYFETGIPK 307 >UniRef50_B1L1I5 D-lactate dehydrogenase n=16 Tax=Clostridium RepID=B1L1I5_CLOBM Length = 334 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 103/333 (30%), Positives = 167/333 (50%), Gaps = 5/333 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFV-NDDGSR 58 MK+ +YS ++++K +++ E+ G +++ + L+E T A + + I N G + Sbjct: 1 MKILMYSVREHEKPAIKKWLEANPGVQIDLCNEALSEDTVCKAKEYDGIAIQQTNSIGRK 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V LK++G+K IA R AG + +DL A + + V VPAY P A+AE A+ M L R Sbjct: 61 DVYSILKEYGIKQIASRTAGVDMIDLKMASDSNILVTNVPAYSPNAIAELAVTHTMNLLR 120 Query: 119 RIHRAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 I +R ++ L + T GV+GTGKIG ++ KG G ++ +D YP Sbjct: 121 NIKTLNKRIAYGDYRWSADLIAREVRSITVGVVGTGKIGRTSAKLFKGLGANVIGYDAYP 180 Query: 178 SAAALELGV-EYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 E + Y L L E+DV++LH PL +++N+ + MK IVNT RG Sbjct: 181 DKKLEENNLLTYKESLEDLLREADVVTLHTPLLESTKYMINKNNLKYMKPDAFIVNTGRG 240 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +I+++ IEAL+ KI +D +ENE + + D +L VL T H Sbjct: 241 GIINTEDLIEALEQNKIAGAALDTFENEGLFLNKVVDPTKLPDPQLDKLLKMDQVLITHH 300 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T A+ +I T+L ++ + K N++ Sbjct: 301 VGFFTTTAVQNIVDTSLDSVVEVLKTNNSVNKV 333 >UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Bacteria RepID=B0KD78_THEP3 Length = 332 Score = 352 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 91/330 (27%), Positives = 151/330 (45%), Gaps = 19/330 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ V + + KY ++V G L E+ + + I +R V+ Sbjct: 5 KVVVTDFEYANLKYEEEVLSKAGITLVPAQCKTEEELILACKDADGL-INQYAKITRRVI 63 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L K K IA G + +D+ AA G+ VV VP Y + V++HA+ +++ R++ Sbjct: 64 EALDK--CKVIARYGIGVDTIDIKAATARGICVVNVPDYCMDEVSDHALALLLGCARKVV 121 Query: 122 RAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + + + + + GK G++G G+I + + FG +L +DPY + Sbjct: 122 LMNNAVKAGTWDFKISKPIYRLRGKVLGLVGFGRIPRTLAEKARPFGFDILVYDPYITQE 181 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +E G V L L S+SD +S+H PLT + YHL+ E MK I+NT+RG +ID Sbjct: 182 DVEPYGATLVGLEELMSKSDFVSVHAPLTEKTYHLIGETEIGLMKPSAFIINTARGPVID 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A I+AL+ ++I G+DV E E L NV+ T H A+ Sbjct: 242 EKALIKALQEKRIAGAGLDVLEQEPT-------------PSDNPLLKMDNVIITPHVAWY 288 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 + E+ + Q ++++ G P LV Sbjct: 289 SEESEAELRTKAAQGVADVLLG-YWPKYLV 317 >UniRef50_B2GCQ6 D-2-hydroxyisocaproate dehydrogenase n=3 Tax=Lactobacillus fermentum RepID=B2GCQ6_LACF3 Length = 327 Score = 351 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 167/324 (51%), Gaps = 2/324 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ +YS ++ Y++ G +++ + L ++TAK A G + + +D V Sbjct: 1 MKILMYSILDTERPYVEAWVNKTGHQVKMVEEGLNKETAKWAAGFDGIDFQQTNDLDPEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ G+K + R GF+ +DL A + L V VPAY P A+AE + + L R++ Sbjct: 61 YATLEGLGIKQLTARMVGFDMIDLKQAADHHLLVTNVPAYSPRAIAEMGLTQALRLVRKL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 QR + +F GL +Y T GVIG G IG A R+ G +LA DP A Sbjct: 121 GYYDQRMDNYDFRWVGLESTEIYNLTVGVIGAGHIGGATARLYSALGANVLATDP-VHHA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LE + YVDL TL E+D++++H PL E +LL+ AF +MK+ ++N +RG L+D+ Sbjct: 180 ELEADLTYVDLETLLREADIVTIHTPLNEETANLLDRTAFAKMKDSAYLINMARGGLVDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEAL+N ++ +D +E F S + + + L A NVL + H AF T Sbjct: 240 AALIEALQNHQLAGAALDTLADETGYFERQASREEVSESYLT-LRAMPNVLISPHSAFFT 298 Query: 301 AEALTSISQTTLQNLSNLEKGETC 324 A+ +I + L ++ + G+ Sbjct: 299 DTAIKNIVEMGLDDVVRIVNGKRP 322 >UniRef50_C0QZF2 Lactate dehydrogenase-like dehydrogenase n=2 Tax=Brachyspira RepID=C0QZF2_BRAHW Length = 331 Score = 350 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 173/329 (52%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + VYS + ++ + + + + + L K A G ++V D + V Sbjct: 1 MSIVVYSFLDDESEFFKLMEKKYNTKFTLHKHHLNIDNVKDAEGFDSVVFNARDAITSEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++LK++GVKY++ R G++N+D+D A ++G+K+ VP+Y P +V+E I ++++ + Sbjct: 61 LDKLKEYGVKYMSTRSVGYDNIDIDYANKIGIKIANVPSYSPNSVSEFTILSLLSIVKNY 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR-LLAFDPYPSA 179 + + N++ GL + GVIGTG+IG ++ LKGF + + + Sbjct: 121 NNLLINGYNRNYTRTGLVAKEIRNLNIGVIGTGRIGSLTVKHLKGFSPKNIFVYSRTEKE 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + +YV L L+ SD I H P E +++ + + +MK GV I+N SRG +++ Sbjct: 181 EIKQY-AKYVSLDELYKNSDAIIYHIPYNKETENMICKDSINKMKKGVYIINVSRGGIVN 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ ++ LK+ IG +DVY NE + ++ + V++D++ L NV+ T H AF Sbjct: 240 NKDLLDGLKSGHIGGAALDVYTNEIEYVNKNIKDIVLKDEIIEELFKMDNVIITPHFAFY 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EAL ++ ++ N+ + C N++ Sbjct: 300 TDEALLNMVSISIDNIFEFKNTGKCVNQI 328 >UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillales RepID=B1HVJ4_LYSSC Length = 535 Score = 350 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 87/329 (26%), Positives = 148/329 (44%), Gaps = 19/329 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFF--DFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 + V+ + + + + +L L E+ + + + +R V Sbjct: 8 INVFIADPLSEDGIFPLRQEQDLDLNIIVDTGLAPEELMTKIADVDVLLVRSQTTVTREV 67 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +K I G +N+DL AA E G+ VV P + + AEH I MM +L R I Sbjct: 68 IEAAKS--LKLIGRAGVGVDNIDLTAATEHGIIVVNAPDGNTNSAAEHTIAMMTSLARHI 125 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+ ++ + + G + KT GV+G G+IGV + KG M ++A+DP+ + Sbjct: 126 PQAFNTLKNGKWDRKSYVGVELKNKTLGVVGFGRIGVEVAYRAKGQRMNVMAYDPFLTDE 185 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A ELGV + + +D I++H PL PE +L+N+ F MK+GV I+N +RG +I+ Sbjct: 186 RAKELGVTKASVEEICEAADFITVHTPLLPETRNLINKEKFAMMKDGVRIINCARGGIIN 245 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A+ K+ +DV+ +E +L V+ T H Sbjct: 246 EDDLYDAIVAGKVAGAALDVFVSEPATD--------------HKLLTLPQVIATPHLGAS 291 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S++ ++ K T N + Sbjct: 292 TIEAQESVAVDVSNDIIKFYKTGTVTNPV 320 >UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acidobacteria RepID=Q1IVI0_ACIBL Length = 531 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 92/330 (27%), Positives = 150/330 (45%), Gaps = 20/330 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFL-LTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V ++ K + + + + D + E+ + G +A+ + Sbjct: 1 MKIVV--AEKIAKAAIDLFKQDPTWNVVTPDQVAQKEQLLEQLKGADALIVRSAVFVDAA 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE ++ I G +N++L+AA G+ V+ P + AVAEH IG+M+ L R Sbjct: 59 MLE--HADQLRVIGRAGVGVDNIELEAATRKGIAVMNTPGANAIAVAEHTIGLMLALARF 116 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 I RA + + + L G + GKT G++G G+IG+ + R FGM L+A DPY S Sbjct: 117 IPRATETMHAGKWEKKSLQGTELRGKTLGIVGLGRIGLEVARRAASFGMTLVAHDPYVSP 176 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A A + + D + + +D I+LH LTP+ +++N MK GV IVN +RG LI Sbjct: 177 AIAHDAKIRLADRDEVLAVADYITLHVGLTPQTANMINATTLATMKKGVRIVNCARGELI 236 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D A EA+K+ +G +DV+ E NV+ T H Sbjct: 237 DDAALAEAVKSGHVGGAALDVFTEEPLKASPYH--------------GVPNVILTPHIGG 282 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA ++ + + + N + Sbjct: 283 STAEAQDAVGVQIAHQVRDYLQRGVVQNAV 312 >UniRef50_C8P1U4 D-lactate dehydrogenase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P1U4_ERYRH Length = 330 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 118/319 (36%), Positives = 184/319 (57%), Gaps = 2/319 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL Y+ + +K+ ++ + +L+ + ++ ANG EAV N D SR V Sbjct: 4 MKLVAYAVRPDEKEAFERFTKEMNIDLKVVNAQMSIDNVNEANGYEAVAFLGNCDASREV 63 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L + G KYIA R AGFNNVD+DA ++LGLK Y P VA+ A+ +++ R + Sbjct: 64 LELLAQGGTKYIASRSAGFNNVDMDAVRDLGLKFSNA-TYSPNCVADFAVMLVLMSLRNM 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R ++SL G+ G M+ T GVIGTG+IG R L GFG R++ +D Y + + Sbjct: 123 KAIMKRAEVKDYSLPGIQGKEMHNMTFGVIGTGRIGCITARNLSGFGGRIIGYDLYENDS 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ++ + YVDL TL E+DVI+LH PL +H++N + K GV+IVN +RG LID+ Sbjct: 183 IKDV-LTYVDLETLLKEADVITLHAPLIESTHHIINAESLALTKPGVIIVNCARGELIDT 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I+ ++N IG++G+DV E E +F +D + + L + NV+ T H AF T Sbjct: 242 DALIKYVENGHIGAVGLDVLEGELGIFHKDHRLSTLSNHQLALLESHKNVIITPHCAFYT 301 Query: 301 AEALTSISQTTLQNLSNLE 319 +A++ + + L++L++ Sbjct: 302 DQAVSDMVEVALRSLNSFM 320 >UniRef50_B7S4E4 2-hydroxyacid dehydrogenase n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7S4E4_PHATR Length = 313 Score = 350 bits (898), Expect = 5e-95, Method: Composition-based stats. Identities = 140/308 (45%), Positives = 197/308 (63%), Gaps = 5/308 (1%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 +EF L+E +A A G +A+C+FVND VL+ L GV+ IA+RCAGF+ VD A Sbjct: 1 MEFTTERLSESSATYAAGYDAICLFVNDTAGSEVLQTLSLMGVQMIAMRCAGFDRVDTKA 60 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE-GLTGFTMYGK 145 A+ G+ V RVPAY P AVAE AI ++MT+NR+I +A R + ANF+L+ GL G +YGK Sbjct: 61 ARAYGMTVARVPAYSPYAVAEMAIALLMTVNRKIAKASNRVKMANFTLDAGLMGMDIYGK 120 Query: 146 TAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHC 205 T GV+GTGKIG + RIL GFG +L+ +D Y S ELG YV +F++SD++ L Sbjct: 121 TVGVMGTGKIGQILCRILNGFGAKLICYDVYESDEVKELGGTYVSKEDIFAQSDILFLMM 180 Query: 206 PLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERD 265 PL +H +NE+ ++K GV+++NTSRG LID+ A ++ L++ I +GMDVYENE+D Sbjct: 181 PLLSATHHTINESVLPKLKKGVLLINTSRGGLIDTAALLKGLRSGIIRGVGMDVYENEQD 240 Query: 266 LFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNL----EKG 321 FF+D S I+D L +NV+ T HQAF T EA+ I TT+ N+ + G Sbjct: 241 YFFQDWSARHIEDPDLVALLGNNNVVLTAHQAFFTQEAVDKIVSTTIDNIRDFHLKRLTG 300 Query: 322 ETCPNELV 329 ++ PN + Sbjct: 301 QSHPNNCI 308 >UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehalococcoides RepID=A5FRL7_DEHSB Length = 526 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 145/329 (44%), Gaps = 20/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK V + L + E +++ L E+ +A+ + + + Sbjct: 1 MK-KVLVSDALSATGLAPLKEIA--QVDVKTGLKPEELISIIGEYDALLVRSQTQVTADI 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + KK ++ I G +N+DL AA G+ VV P + + EH + +M+ + R I Sbjct: 58 INAGKK--LQVIGRAGVGVDNIDLKAATGNGIIVVNAPTGNTISATEHTLALMLAMARHI 115 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-A 179 RA + + G + GKT G++G G IG + + MR++ +DP+ S Sbjct: 116 PRANASLKSGQWKRNEFVGSELKGKTLGIVGLGNIGSEIAKRALALEMRVIGYDPFISME 175 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +L VE + L ++D I+LH P+T + L+ E MK V ++NTSRG +ID Sbjct: 176 RAKKLQVELLPFEDLLKQADFITLHVPMTGQTKGLIGPKELEMMKPTVRLINTSRGGIID 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A +A+K ++IG +DV+ E L C N++ T H Sbjct: 236 EEALAKAVKEKRIGGAAIDVFSKEPCTE--------------SCLFECDNIIVTPHLGAS 281 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA + ++ + ++ +G + Sbjct: 282 TAEAQELATSDVVKQVIDVFEGRPARYAV 310 >UniRef50_Q6RK69 D-lactate dehydrogenase n=4 Tax=Lactobacillus RepID=Q6RK69_9LACO Length = 331 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 109/332 (32%), Positives = 182/332 (54%), Gaps = 5/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL VY+ + + ++++ E+ L +TA A G + V S+ + Sbjct: 1 MKLIVYNVRDDEIPFVEKWGRDHQIEVTTTTTTLNTETAAEAAGFDGVSCLQTIPYSKEL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++ G+ Y+ALR G +N+D+ AAK +K+ VPAY PE++AE A+ M + L+R++ Sbjct: 61 FAALQRLGIHYLALRNVGTDNIDIQAAKANNVKITNVPAYSPESIAEFAVMMALYLSRKV 120 Query: 121 HRAYQRTRD-ANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 Q+ ++ F G + +T GVIGTG+IG +++ +G G ++A+D YP Sbjct: 121 GYMQQQLQEQHEFHFSPAFMGRLISEQTVGVIGTGRIGRHAIQLFRGLGANVIAYDKYPQ 180 Query: 179 AAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +YVD L + +SD+ISLH P T +N+HL N FE+MK +++NT+RG + Sbjct: 181 KITGGA-FKYVDHLEDIIKQSDIISLHMPATADNFHLFNHEVFEEMKPNAILINTARGTI 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D+ I AL++ +I + G+D E+E + +S I D +LS NV+ T H A Sbjct: 240 VDTNDLIFALESGEIAAAGIDTLEDESIDLQDSRSTKKITDADLIKLSMMPNVILTPHSA 299 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 F T E++ ++ +L NL + +G P +LV Sbjct: 300 FHTTESVKNMVNISLNNLKTMAEGGK-PADLV 330 >UniRef50_C3RQ64 D-lactate dehydrogenase n=4 Tax=Bacteria RepID=C3RQ64_9MOLU Length = 330 Score = 349 bits (897), Expect = 7e-95, Method: Composition-based stats. Identities = 110/328 (33%), Positives = 184/328 (56%), Gaps = 2/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + + + +N S FE+ ++ L +K NG + + + + Sbjct: 1 MKIIAFEVRSDEMADFEIMNNSNNFEITYYKEYLCQKNLSLLNGYDGIAFLGESKINHEI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ + K G+ IA R G++++D++ AKELG+KV +Y PE VA+ + +M+ R Sbjct: 61 LDAIAKAGIGVIATRTIGYDHIDIEYAKELGIKVCNS-SYGPEGVADFTVMLMLLSLRHY 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + ++SL+GL G M T G++GTG+IG A+L+ L GFG RLLA+D + + Sbjct: 120 KKALWLGQVNDYSLQGLEGREMKDLTIGIMGTGRIGQAVLKNLSGFGARLLAYDIHQNET 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A + YVDL + E D+ISLH P +HL+N+ +MK+G++I+N +RG L ++ Sbjct: 180 AK-IYATYVDLEQFYQECDIISLHMPYLKSTHHLINDQTISKMKDGIIIINCARGQLCNT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 ++ I ++N+KIG+LG+DV E E ++ +D D+I++ L NV+ T H AF T Sbjct: 239 ESLIRGIENKKIGALGLDVVEGEEGIYHQDMRTDIIKNKNMAYLRQFPNVVMTQHLAFYT 298 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A++S+ Q +L L NEL Sbjct: 299 DAAVSSMVQLSLNGLWACYNDLDWDNEL 326 >UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n=11 Tax=Bacteria RepID=A0Q365_CLONN Length = 317 Score = 349 bits (897), Expect = 8e-95, Method: Composition-based stats. Identities = 94/326 (28%), Positives = 157/326 (48%), Gaps = 21/326 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNE---SFGFELEFFDFLLTEK--TAKTANGCEAVCIFVNDD 55 M+++V K+ + + + G E+ F+ + +K + A E V + N Sbjct: 1 MRISVLEPLGLPKEEVYSIAKPIIDKGHEVILFEDKVQDKKVLMERAKDAE-VLVLANMP 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V++ +K I++ G ++VD A E + V Y +VAE G++ + Sbjct: 60 LEGEVIKS--DDKLKMISVAFTGIDHVDTKACTEKQVMVCNAAGYSTSSVAELTYGLIFS 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + R I + TR+ + G + + GKT G++GTG IG+ + +I K FG +LA+ Sbjct: 118 VLRNIVPLDKATREGK-TRNGFSQNEILGKTIGIVGTGAIGIRVGQIAKAFGCNVLAYSR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A++ G +YV L L S+SD++SLH PL E L+++ E MK+ +++NT+RG Sbjct: 177 SERKEAIDTGFKYVSLDELLSKSDIVSLHVPLNDETKGLISKEKIELMKSSSILINTARG 236 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D+ A EALK KI G+DV+E E + E L NV+ T H Sbjct: 237 PVVDNSALAEALKKGKIKGAGIDVFEIEPPISKE------------HPLFNAPNVVVTPH 284 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKG 321 AF T EA+ + +N+ G Sbjct: 285 IAFATEEAMYRRCEIVFKNIEKWLDG 310 >UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n=2 Tax=Verrucomicrobia RepID=B3DVF6_METI4 Length = 531 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 90/326 (27%), Positives = 149/326 (45%), Gaps = 17/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + KK + ++ S ++ L ++ A+ + V + +R V+E Sbjct: 7 ILIADPISKKGIAELQASAQLIVDEKYGLKEDELARVIADYDGVIVRSQTKITRKVIEAG 66 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 KK +K I G +NVD+DAA E G+ V+ P + A AEH +++ L R + +A+ Sbjct: 67 KK--LKVIGRAGVGIDNVDVDAATEKGIVVMNTPGGNTIATAEHTFSLLLALARNVAQAH 124 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE- 183 + + + G +YGK G+IG G++G+ + + FGM++ FDPY S ++ Sbjct: 125 ASMQLGEWKRKNFEGIELYGKILGIIGLGRVGMEVAKRALAFGMKVKCFDPYLSPTKVKN 184 Query: 184 LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 L VE V L LF + D +SLH PLT E ++N+ ++ K G+ I+N +RG LI Sbjct: 185 LQVELVNSLDELFQDIDFLSLHVPLTQETEGIINKDNLKKCKRGIRIINCARGGLIRIAD 244 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 E LK+ + +DVYE E L NV+ T H A T E Sbjct: 245 LEELLKSGWVAGAALDVYEPEPP-------------PADFPLRGLPNVVLTPHLAASTIE 291 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + ++ N + Sbjct: 292 AQENVGTEIAAMVIDVLCHNIIRNAV 317 >UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms RepID=B0TB58_HELMI Length = 328 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 95/333 (28%), Positives = 155/333 (46%), Gaps = 22/333 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTE--KTAKTANGCEAVCIFVNDDGSRP 59 + V T++ + L ++ E +L + F E + + +A+ + D Sbjct: 6 RPKVLVTREIPQPALDRIKEFARLDL-WPAFPPPEKGELQRMLADADALLCMITDPIDDD 64 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V+E KK ++ IA G++N+D+ AA + V P EA A+ A +++ R Sbjct: 65 VIEAGKK--LRVIANYGVGYDNIDIAAATRRRIAVTNTPDALTEATADLAFALLLATARN 122 Query: 120 IHRAYQRTRDA---NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 + A + TRD + + L G ++G T G++G G+IG A+ R +GF M +L Sbjct: 123 LIAADRFTRDGFWIAWHPQLLLGRDVFGSTLGIVGLGRIGEAVARRARGFNMHVLYTARR 182 Query: 177 PSA-AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 + A ELG+EY L L SD +SLH PLT E HL+ MK +++NT+RG Sbjct: 183 RNPKAEAELGIEYCTLEELLRRSDFVSLHTPLTLETRHLIGAKELNMMKPTAILINTARG 242 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D +A EAL+ IG G+DV+ E E L NV+ + H Sbjct: 243 GVVDQEALTEALQQGVIGGAGLDVFAEEPVAPEE-------------ALLELPNVVVSPH 289 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA T + ++N+ + +G PN + Sbjct: 290 IGSATVEARTRMGLMAVENIQAVLEGRRPPNLV 322 >UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (class) RepID=B9L1V2_THERP Length = 333 Score = 347 bits (892), Expect = 2e-94, Method: Composition-based stats. Identities = 95/331 (28%), Positives = 161/331 (48%), Gaps = 29/331 (8%) Query: 3 LAVYSTKQYDKKYLQ----QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 +S ++ ++L+ + E E+ + + E+ + + + + + + + Sbjct: 19 WKYFSAREEIARFLEERGCRFVEK---EIRYP--VDEEQLCELVRDVDGLVVGL-EPITA 72 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 VL + +K I+ GF+N+D+ A G+ V + +VAE A G+M+ L R Sbjct: 73 RVL--AHANRLKVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALAR 130 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YP 177 IHR+ + R+ + E G ++GKT GVIG G+ G A+ + +GFGMR+LA D + Sbjct: 131 GIHRSDRLMREGRW--EPYFGVELWGKTLGVIGLGRAGRAVALLGRGFGMRVLAHDIVWD 188 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + A + YV L L ESD +SLH PLTP+ +L++E A MK ++N +RG + Sbjct: 189 TTFANAHEISYVPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFLINLARGPV 248 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 + A +EAL+ +I G+DV+E E I+D+ F NV+ T H Sbjct: 249 VKQSALVEALRRGQIAGAGLDVFEVEP-----------IRDNPF---VEFENVVMTPHLG 294 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA L N+ N+ G +++ Sbjct: 295 GSTEEARERTLYLALTNVCNVLNGRPPHHQV 325 >UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2G1_9PLAN Length = 316 Score = 347 bits (892), Expect = 2e-94, Method: Composition-based stats. Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 19/325 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T+ + ++ + E + + + + + A+ + R +++ Sbjct: 4 VLVTENIQGVSMNRLIQEHDVEFDAYLWQNIDLLKQKIQNTRALIVRNQTKVDRELIDAA 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K IA AG +NVD + A E G+ V P + +VAE IG+M+ L R+I A Sbjct: 64 PE--LKIIARAGAGLDNVDTEYAHEKGIVVCFTPDANSLSVAELTIGLMLALMRKIPEAR 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA--- 181 Q T ++ TG +YGK+ G+IG G+IG K FGM +LA DP+ A A Sbjct: 122 QDTLTGGWNRLKFTGTELYGKSFGLIGLGRIGSFTATRAKAFGMNILAADPFLKADAPQL 181 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +L + L L +ESDV+S H PLTP+ +L F +MK +NTSRG ++D + Sbjct: 182 KKLNATLLSLDDLLAESDVVSCHSPLTPDTRKMLTYQHFRKMKPDAFFINTSRGEVVDER 241 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 +AL K+ +DV E E L+ NV+ T H A T Sbjct: 242 GLTQALLEHKLAGAALDVRETEPPKQ--------------SPLNQMENVILTPHIAAFTV 287 Query: 302 EALTSISQTTLQNLSNLEKGETCPN 326 EA + + +++ + G+ N Sbjct: 288 EAQDRVVDSVCEDVRLVLSGKKAIN 312 >UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A9WCW3_CHLAA Length = 525 Score = 347 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 145/325 (44%), Gaps = 18/325 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + T++ + L + ++ ++ L +A+ + + V+ Sbjct: 4 ILVTEKIAAEGLAVLRQAGTVDVRL--DLDKPTLISIIGEYDALVVRSATKVTAEVIAAG 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ ++ I G +N+D++AA G+ VV PA + AVAE IG++++L RRI +A+ Sbjct: 62 ER--LRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAH 119 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALE 183 + ++ G+ + GKT G++G G+IG + R + M +LA+DP S A + Sbjct: 120 ASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQ 179 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LGV V L L SDVISLH PL +L ++ QMK G ++N SRG ++D A Sbjct: 180 LGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVAL 239 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +EAL + +G +DVY E L ++ H T EA Sbjct: 240 VEALNSGHLGGAALDVYNQEPL-------------PADSPLLGHPKIITVPHIGASTTEA 286 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 S + + G T + Sbjct: 287 QLSAGTEMAEGVVTALNGGTPRYAV 311 >UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planctomycetaceae RepID=C1ZMC1_PLALI Length = 546 Score = 346 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 87/326 (26%), Positives = 153/326 (46%), Gaps = 17/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T L+ + E+ G E++ L ++ + + + I + +L++ Sbjct: 4 VLITDNLSPAGLKILKETPGIEVDLRKGLTPDEVRVALHDADGIIIRSETKLTPEILKDQ 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K I G +N++L AA G+ V+ PA + + AEH I MMM L+R I A Sbjct: 64 PR--LKAIVRAGVGTDNINLPAATREGIVVMNTPAGNTTSTAEHTIAMMMALSRNIAPAA 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALE 183 + RD + + TG + GK+ ++G G+IG+A+ R G M++L FDP+ S A E Sbjct: 122 SKLRDGVWDRKSFTGTQLAGKSIAIVGLGRIGLAVARRAMGLEMKVLGFDPFMSVERAAE 181 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 G+E Y D+ + ++ D +++H PL+PE +L+ +MK GV I+N +RG +I+ Sbjct: 182 QGIELYRDIDEMITKCDYLTVHTPLSPETTNLIGAERLAKMKKGVRIINCARGGIINEAE 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +A+++ IG +DV+ E L VL T H A T E Sbjct: 242 LAQAIESGHIGGAALDVFVKEPT-------------PPDNPLLKLPQVLCTPHLAASTDE 288 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + ++ + + Sbjct: 289 AQELVAVEAAEIMAGFLVRHEVRHAV 314 >UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Bacillales RepID=SERA_BACSU Length = 525 Score = 346 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 82/318 (25%), Positives = 145/318 (45%), Gaps = 20/318 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + LQ + ES E+ + E T +A+ + + + ++ Sbjct: 4 VLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHT---FDALLVRSATKVTEDLFNKM 60 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K + G +N+D+D A + G+ V+ P + + AEH M+ +L R I +A Sbjct: 61 --TSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFAMISSLMRHIPQAN 118 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + ++ G +YGKT G++G G+IG + + + FGM + FDP+ + A + Sbjct: 119 ISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAFGMTVHVFDPFLTEERAKK 178 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 +GV + +D+I++H PLT E LLN+ + K GV ++N +RG +ID A Sbjct: 179 IGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCARGGIIDEAAL 238 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +EAL+N + +DV+E E V +L V+ T H T EA Sbjct: 239 LEALENGHVAGAALDVFEVEP--------------PVDNKLVDHPLVIATPHLGASTKEA 284 Query: 304 LTSISQTTLQNLSNLEKG 321 +++ + + KG Sbjct: 285 QLNVAAQVSEEVLQFAKG 302 >UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CRA6_9FIRM Length = 321 Score = 346 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 110/332 (33%), Positives = 169/332 (50%), Gaps = 27/332 (8%) Query: 1 MKLAVYSTKQYD---KKYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVND 54 MK+ V T K L+++ F EL F D L E+ GC+ + D Sbjct: 3 MKILVTPTSLQPGRKSKALERLR-DFSEELVFNDKSRPLTEEELIPLLKGCQGYLAGL-D 60 Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 + VL E + +K I+ G++ +D+ AA + G+ V P + +AV E A G+++ Sbjct: 61 FITERVLREAED--LKVISRYGTGYDRIDMAAASQYGVTVTNTPGVNAQAVGELAFGLLL 118 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 ++ R+I + TR + G + GKT G++G G IG + R KGFGMR+ A D Sbjct: 119 SVARQISYLDRTTRSGEWVRAE--GVELKGKTLGILGLGAIGKVVARCAKGFGMRVAASD 176 Query: 175 PYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 P+ E G+E +D+ L S +D +SLH PL E HL+ + A +MK+GV+++NTS Sbjct: 177 PFIDREYCREHGIEAMDMEDLLSFADAVSLHLPLNKETTHLIGKEALARMKDGVILINTS 236 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +ID +AA LK+ KIG LG+D +ENE L NV+ T Sbjct: 237 RGGIIDEEAAYCGLKSGKIGGLGLDAFENEPPKG--------------SSLFEFSNVVAT 282 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 H T EA + +++ + NL ++ +GE CP Sbjct: 283 PHTGAHTKEAASMMAERAVDNLISVLQGERCP 314 >UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HSQ7_9FIRM Length = 317 Score = 346 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 92/319 (28%), Positives = 150/319 (47%), Gaps = 22/319 (6%) Query: 14 KYLQQVNESFGFELEF--FDFLLTE-KTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVK 70 + V E G E+ F +D LTE + + G +A+ + D + V+ +K Sbjct: 15 PEARAVLEQAGCEVIFNPYDRPLTEDELVELIKGMDALVAGM-DAVTAKVI-AAGLPTLK 72 Query: 71 YIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDA 130 IA G+N +D+ AA G+ V P + +VAE AIG+M+ + R I + R Sbjct: 73 IIAKHGVGYNTIDVAAAAAYGIPVTITPGANNISVAELAIGLMLAVARHIPQMDGIVRRG 132 Query: 131 NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVEYV 189 +S +TG +YGK G+IG G IG + + FGM+++A+D P +E GV Y+ Sbjct: 133 GWSR--MTGSELYGKVLGIIGMGSIGCEVAKRAHAFGMKIIAYDIRPRQDMIENYGVTYL 190 Query: 190 DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKN 249 + +++D +SLH P PE ++N+ + MK ++NT+RG LI + +ALKN Sbjct: 191 PMADCLAQADFLSLHAPALPETIGMINKDTLKTMKRTAFLINTARGDLIVEEDLYDALKN 250 Query: 250 QKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQ 309 I G+D + +E RL NV+ T H T EA+T + Sbjct: 251 GVIAGAGLDTFVHEPIRD--------------ARLFTLDNVVLTPHAGATTHEAVTRMGV 296 Query: 310 TTLQNLSNLEKGETCPNEL 328 + + + G+ N + Sbjct: 297 MAAEEVVRVLSGQPPQNPV 315 >UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMC8_9FIRM Length = 530 Score = 346 bits (889), Expect = 6e-94, Method: Composition-based stats. Identities = 93/326 (28%), Positives = 153/326 (46%), Gaps = 17/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 ++ T K+ + + + F ++ + ++ K +AV ++ V+ Sbjct: 3 KIFITADVAKEAKEFLEKE--FVVDIRPNMDEDELCKVIGEYDAVITRSQTKITKNVIHA 60 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K I G + +D+ A G+ VV P + A EH + +M+++ R I +A Sbjct: 61 A--TNLKVIGRAGVGIDGIDIPEATAKGITVVNTPESNTIAACEHTLALMLSITRYIPQA 118 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 +Q + + + TG + KT G+IG G++G + + L+ F M+ + +DPY P Sbjct: 119 HQSIMEGRWDRKSFTGIQLLNKTVGIIGVGRVGSNVAKRLQAFNMKTIGYDPYIPLERGQ 178 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 +LGV+ VDL TL ESD I+LH PLT E ++ E+MK+GV IVN SRGA+ID A Sbjct: 179 QLGVDLVDLDTLLRESDYITLHTPLTEETKGMIGAKEIEKMKDGVRIVNASRGAVIDIDA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 EALK K+ G+DV+ NE + NV T H T E Sbjct: 239 LAEALKTGKVAGAGIDVWTNEPLKPENNPF------------LGMKNVTLTPHLGASTVE 286 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A T ++ + +++ GE + Sbjct: 287 AQTGVATDVARGVADALHGEPVATAV 312 >UniRef50_Q11QU3 D-lactate dehydrogenase n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11QU3_CYTH3 Length = 329 Score = 345 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 153/329 (46%), Positives = 209/329 (63%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ YS + YDKK+ + N F E+ + L+ +TA A G AVCIFVNDD PV Sbjct: 1 MKILFYSARSYDKKHFEAANPGT-FTFEYIEEALSIETAHYAEGAFAVCIFVNDDACAPV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L +GVK IA+R AG + + AA LG+ V VPAY P A+AEH + M++ L R I Sbjct: 60 LEKLASYGVKGIAIRAAGHDQTNHVAAHRLGMHVANVPAYSPHAIAEHTVTMILALTRHI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A R + +NF L+ L GF ++ KT G+IG GKIG +IL GFG L AFDPYP+ Sbjct: 120 VEADNRVKQSNFILDPLVGFNIHHKTVGIIGLGKIGGLTAKILHGFGCTLQAFDPYPNQE 179 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + G++Y + + + SD+I +H PL +L++ + + MK+GVMIVNT RGA+I+ Sbjct: 180 YTDKYGLQYKSIEEVLATSDIIVIHAPLNAHTKYLIHADSIKTMKDGVMIVNTGRGAIIN 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ AI+ L + KIG LG+DVYENE+ LFF D S + D+VF L+ NVL TGH AFL Sbjct: 240 TKDAIDGLTSGKIGYLGLDVYENEKGLFFSDHSVNKPTDEVFLALTKFKNVLITGHMAFL 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T ALTSI+QTTL+NL G+ +E+ Sbjct: 300 TTNALTSIAQTTLENLRAWSNGKDADHEI 328 >UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplastic n=43 Tax=Viridiplantae RepID=SERA_ARATH Length = 624 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 17/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K + T++ + + + E + + L E K +A+ + +R V Sbjct: 82 KPRILVTEKLGEAGVNLLREFGDVDCSY--DLSPEDLKKKVAESDALIVRSGTKVTREVF 139 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E K +K + G +NVDL AA E G VV P + A AEH I ++ ++ R + Sbjct: 140 EA-AKGRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVA 198 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAA 180 +A + + G ++ GKT V+G GK+G + R KG GM +++ DPY P+ Sbjct: 199 QADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADR 258 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A LGV+ V S +D +SLH PLTP + N+ F +MK GV ++N +RG +ID Sbjct: 259 ARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDE 318 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + AL + +DV+ E RL NV T H T Sbjct: 319 DALVRALDAGIVAQAALDVFCEEPPSKD-------------SRLIQHENVTVTPHLGAST 365 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA ++ + ++ KGE + Sbjct: 366 KEAQEGVAIEIAEAVAGALKGELSATAV 393 >UniRef50_P26297 D-lactate dehydrogenase n=73 Tax=Lactobacillales RepID=LDHD_LACDA Length = 333 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 107/328 (32%), Positives = 172/328 (52%), Gaps = 1/328 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K+ Y+ ++ +K +L++ ++ E+E+ D LLT +T A G + V ++ D + Sbjct: 3 KIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGVVVYQQLDYTAET 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L +G+ ++LR G +N+D+ AKELG ++ VP Y P A+AEHA + R+ Sbjct: 63 LQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILRQD 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 ++ + G + + GVIGTG IG ++I++GFG +++A+D + + Sbjct: 123 KAMDEKVARHDLRWAPTIGREVRDQVVGVIGTGHIGQVFMQIMEGFGAKVIAYDIFRNPE 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + G L L+ ++DVISLH P P N H++N+ + +MK V+IVN SRG L+D+ Sbjct: 183 LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDT 242 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I L + KI MDVYE E +F ED D L A NVL T H AF T Sbjct: 243 DAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAFYT 302 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++ N L +G+ + Sbjct: 303 THAVRNMVVKAFDNNLELVEGKEAETPV 330 >UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria RepID=Q5SZU1_HUMAN Length = 499 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 77/284 (27%), Positives = 132/284 (46%), Gaps = 17/284 (5%) Query: 41 TANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAY 100 CE + + + V+ +K ++ + G +NVDL+AA G+ V+ P Sbjct: 10 LLQDCEGLIVRSATKVTADVINAAEK--LQVVGRAGTGVDNVDLEAATRKGILVMNTPNG 67 Query: 101 DPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAML 160 + + AE GM+M L R+I +A +D + + G + GKT G++G G+IG + Sbjct: 68 NSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVA 127 Query: 161 RILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAA 219 ++ FGM+ + +DP S + GV+ + L ++ D I++H PL P LLN+ Sbjct: 128 TRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNT 187 Query: 220 FEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDD 279 F Q K GV +VN +RG ++D A + AL++ + +DV+ E Sbjct: 188 FAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPRD------------ 235 Query: 280 VFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGET 323 R L NV+ H T EA + + ++ KG++ Sbjct: 236 --RALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKS 277 >UniRef50_C8P020 D-lactate dehydrogenase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P020_ERYRH Length = 331 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 100/329 (30%), Positives = 168/329 (51%), Gaps = 3/329 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V++ ++ +++ + E+ + L+ G + + N + Sbjct: 3 KFIVFNVREEERELTLDWAKRNNVEVTMAEGQLSMDNIHMVEGFDGLSTSQNTKLEPEMY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 LK +G+K IA R AGF+ DLD A E GL + VP+Y PE++AE ++ ++L R++ Sbjct: 63 SILKGYGIKQIAQRSAGFDYYDLDLATENGLIITNVPSYSPESIAEFSVTSALSLIRKLR 122 Query: 122 RAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 ++TR +F + + + T GV+GTG IG + FG ++LAFD Y + Sbjct: 123 VIEEKTRQHDFRWQPQIRAGLLKEMTVGVVGTGHIGRKSAELFSAFGAKVLAFDVYQNEE 182 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A + V YVD + L S SDV+SLH P T +N+H N F + K +N +RG+++D Sbjct: 183 AKQY-VTYVDSVEELVSMSDVVSLHVPATKDNHHQFNAEMFRKFKPNAYFINAARGSVVD 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A IEAL + +D YENE +D SN I+D++F + +LFT H A Sbjct: 242 TKALIEALNQGHLAGAALDTYENESPFIPKDFSNQTIEDELFLEVLNHEKILFTPHIAHY 301 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T ++ +I + L ++ + + T N + Sbjct: 302 TDVSVRNIMEFALTSVLEILETGTTANRV 330 >UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 Tax=Bacteroides coprophilus DSM 18228 RepID=UPI000197AFFA Length = 315 Score = 343 bits (881), Expect = 5e-93, Method: Composition-based stats. Identities = 102/326 (31%), Positives = 156/326 (47%), Gaps = 21/326 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNE---SFGFELEFFDFLLTEKT-AKTANGCEAVCIFVNDDG 56 M + + + + L + G + L + + A + + I N Sbjct: 1 MNIVLLESLGISPERLSEYARPLVEAGHTFNAYPRDLDIQVQIERAREADVIII-ANMPL 59 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 V+ K +K+I + G ++VDLDAA+E G+KV Y +AVAE A+ MM++L Sbjct: 60 RGEVIRACKH--LKFIDVAFTGVDHVDLDAARECGVKVSNAAGYSTQAVAELALCMMLSL 117 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R + + R R + +GL G + GKT G++G G IG + K FG R+L + Sbjct: 118 LRNVPQVAGRCRQGK-TKDGLVGCELRGKTVGIVGAGAIGTRTAELCKAFGCRVLGNKRH 176 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + +E++ L L S+SD++SLHCPLT E L+N MK G ++NT+RG Sbjct: 177 LTGKEPSF-IEFMPLEELLSQSDIVSLHCPLTAETRQLINADRLGMMKQGAYLINTARGG 235 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++DS A EALKN + G+DV+E E L D L NVL T H Sbjct: 236 VVDSAALAEALKNGYLAGAGIDVFETEPPL------------DPAHPLLQAPNVLATPHV 283 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGE 322 AF + E++ + + NLSN G+ Sbjct: 284 AFASEESMEARAAIVFSNLSNWMDGK 309 >UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate dehydrogenase n=2 Tax=Apocrita RepID=UPI0000DB72A4 Length = 478 Score = 343 bits (881), Expect = 5e-93, Method: Composition-based stats. Identities = 80/307 (26%), Positives = 139/307 (45%), Gaps = 15/307 (4%) Query: 18 QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCA 77 ++ G + L EK K E + + + V ++ + Sbjct: 20 ELLVRHGIPVTTKYKLSKEKLIKELQNHEGLIVRSETKVTADVFACCP--NLRVVGRAGT 77 Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 G +N+DL+AA G+ V+ P + + E ++ L R + +A Q +D + + Sbjct: 78 GVDNIDLEAATRKGVIVLNTPGGNSISACELTCALISNLARNVTQAVQSLKDGRWDRKLY 137 Query: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-SAAALELGVEYVDLPTLFS 196 +GF + GKT V+G G+IG + R ++ +GMR++AFDP S A L VE L ++ Sbjct: 138 SGFELSGKTLAVLGMGRIGREVTRRMQAYGMRVIAFDPLLTSEDANYLNVEKFSLDEIWP 197 Query: 197 ESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLG 256 +D I++H PL P+ +L+N + K GV I+N +RG ++D +A + ALK+ Sbjct: 198 MADYITVHTPLIPQTKNLINATTLAKCKKGVRIINVARGGIVDEEALLNALKSGHCAGAA 257 Query: 257 MDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLS 316 +DV+ E ++ V L A V+ T H T EA +++ Q Sbjct: 258 LDVFTEEPP-----------KNSVILELIAHPKVISTPHLGASTEEAQQRVAEEIAQQFL 306 Query: 317 NLEKGET 323 + G + Sbjct: 307 -VLAGRS 312 >UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4AUS0_9CHRO Length = 326 Score = 343 bits (880), Expect = 6e-93, Method: Composition-based stats. Identities = 82/331 (24%), Positives = 147/331 (44%), Gaps = 21/331 (6%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLL-TEKTAKTANGCEAVCIFVNDDGSRPVLE 62 ++ T+Q ++ L + E+ E + + + + D ++ Sbjct: 5 KIFVTRQLPERGLNPLLSHAEIEIWPERQPPAYEILLEKVQQIDGLLCLLTDRIDEQLIN 64 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K I+ G++N+D+ AA + V P +A A+ ++M RRI Sbjct: 65 TGKS--LKVISQMAVGYDNIDIKAATNRKIPVGNTPGVLTDATADLTWALLMCAARRIIE 122 Query: 123 AYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + Q R ++ L G + G T G++G G+IG A+ R GF +R++ + + Sbjct: 123 SEQYVRAGSWQTWEPTLLLGTDLSGATLGIVGLGRIGEAVARRASGFNLRVIYSSRHRRS 182 Query: 180 AALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +E LGVEYV+ L ESD+I+LH L+ E +HL++ A F MK +++NT+RGA+ Sbjct: 183 KEIEAALGVEYVEFNRLLQESDIITLHTALSKETHHLISYAQFALMKRSAILINTARGAI 242 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D QA + LK+ +I +DV E E + L + N++ T H Sbjct: 243 VDPQALYQTLKSGQIAGAALDVTEPEPI-------------PLDSPLLSLKNLIITPHIG 289 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + + ++ NL + P + Sbjct: 290 SASYQTRLKMATMAANNLLAGLLNQPLPYCV 320 >UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacillaceae RepID=A6CKS4_9BACI Length = 322 Score = 343 bits (880), Expect = 7e-93, Method: Composition-based stats. Identities = 93/327 (28%), Positives = 154/327 (47%), Gaps = 20/327 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V + K+ + + E G E+ E + +A+ I SR V Sbjct: 1 MNFKVLIPQPIAKEGID-LLEKEGAEVIIPPDYNEETLISHVSDVDAILIR-TAKLSRVV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+ K +K IA G +N+DL+AA + G+ V P + AVAEH + ++++ +R++ Sbjct: 59 IEKASK--LKVIARHGIGVDNIDLEAASDRGILVTNAPFANVNAVAEHVLTLILSGSRQL 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 + R+ +F G + GKT GV+G G IG + G GM +L +DPY Sbjct: 117 IQVDSALRNGDFEVRNRKFGIELKGKTLGVVGFGNIGQLVAEKCHYGLGMDVLVYDPYVR 176 Query: 179 AAALELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + V+ L + + SD++++H P P +HL+NE A +QMK ++VN +RG + Sbjct: 177 EENVSSYVQLNQSLSEVLASSDIVTIHVPYLPSTHHLINEEALQQMKKDAILVNAARGGI 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID A +AL + +I +D +E E V L NV+ T H A Sbjct: 237 IDEIALEKALGSGEIRGACLDCFETEPPA-------------VDHSLWNLENVIVTPHLA 283 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETC 324 T EA+ ++ T +++ + KGE Sbjct: 284 AHTEEAMIEMAVTPAKDIIAIMKGEKP 310 >UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DLZ3_9ACTO Length = 324 Score = 342 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 83/298 (27%), Positives = 133/298 (44%), Gaps = 19/298 (6%) Query: 32 FLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELG 91 A G + + D S V+ + +K G++N+D+ AA E G Sbjct: 39 DSSPATLAALVTGFDGIVA-GTDRFSAEVIAAADR--LKVFGRTGVGYDNIDVAAATERG 95 Query: 92 LKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIG 151 + V P + ++VAEH +++++ R + ++ ++G + G T G+IG Sbjct: 96 IAVCPTPGVNRQSVAEHTFALLLSVARGVPGNVTAVAAGDWP--QVSGRELSGATLGLIG 153 Query: 152 TGKIGVAMLRILKGFGMRLLAFDPYPSAAALEL-GVEYVDLPTLFSESDVISLHCPLTPE 210 G IG A+ RI GFGMR++A DPY A A+ GVE L L + +D +SLH L Sbjct: 154 LGAIGKAVARIALGFGMRVIAHDPYLDAEAVAASGVERASLDELLATADFVSLHIFLDDA 213 Query: 211 NYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFED 270 HL++ A MK G +VNTSRG ++D A AL+ ++ G+DV E E Sbjct: 214 TRHLIDAEAIATMKPGAYLVNTSRGGVVDETALAAALREGRLSGAGLDVLETEPL----- 268 Query: 271 KSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 L N++ T H T E+ + Q + ++ G T + + Sbjct: 269 --------PPDSPLRGLDNLIITAHIGAATVESRARSGRMAAQAVIDVLDGRTPEHVV 318 >UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Firmicutes RepID=Q04AA8_LACDB Length = 316 Score = 342 bits (879), Expect = 9e-93, Method: Composition-based stats. Identities = 95/333 (28%), Positives = 162/333 (48%), Gaps = 22/333 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF---GFELEFFDF--LLTEKTAKTANGCEAVCIFVNDD 55 MK+ + ++ L ++ E G E +D TE+ K + +A+ I N Sbjct: 1 MKIVLLEPLGISQESLDKLAEKLTKQGHEFTAYDSFSTDTEELKKRSEDADALII-ANHL 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V+ +K+I++ G ++VDL+A KE + + Y +AVAE AIG+ + Sbjct: 60 LPGEVIRA--DKNLKFISVAFVGIDHVDLEACKEKKINISNTGGYCNDAVAELAIGLTLD 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R+I + + GL G + GKT G++GTG IG I K FG +L+ + Sbjct: 118 CLRKISAGNEAVQAGE-GKGGLQGHELAGKTVGIVGTGAIGCRTAEIFKAFGCKLIGYSR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 AAAL+LG+EY L + E+D++S+H PLTPE L+ + +MK G +++NT+RG Sbjct: 177 SQKAAALDLGLEYKSLDEVMGEADIVSIHTPLTPETKGLIGKKEIGEMKEGAILINTARG 236 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D++A ALK +I G+DV++ + L L N++ + H Sbjct: 237 PVVDTEALAAALKEGRIK-AGLDVFDQDPPL------------PADYPLLGVPNLVCSPH 283 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T E++ ++ +N++ G+ L Sbjct: 284 VGFDTKESIDRRAEMAFENVTAWLNGQQIRTML 316 >UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacteria RepID=Q5WLJ2_BACSK Length = 316 Score = 342 bits (879), Expect = 9e-93, Method: Composition-based stats. Identities = 95/326 (29%), Positives = 158/326 (48%), Gaps = 24/326 (7%) Query: 1 MKLAVYSTK--QYDKKYLQQVNESFGFE-LEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 MK+ S ++ + + ++ + G E + + A G +A + N+ Sbjct: 1 MKVICTSPSFAKHSNEPIIRLQQE-GIELVRVPPDISQSAFVLEARGAQAAIVAFNEIHD 59 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 VL +L +K IA G +N+D+DAAK+ G+ V VP + AVA+ A ++++L Sbjct: 60 A-VLAQLPD--LKIIAKHGVGVDNIDVDAAKKHGVTVTNVPNANKHAVADFAFSLLLSLA 116 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+I ++T+ + L G +Y +T G+IG G IG + R GF M +LA+DPY Sbjct: 117 RQIPTGNEKTKKGKWP--SLFGADVYQQTLGIIGLGAIGKEVARRASGFSMTVLAYDPYI 174 Query: 178 SAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A + G+E V L L +SD +++H PL PE HL+ E + MK +VN SRG Sbjct: 175 DRTYARKNGIEAVSLDALLQQSDFVTIHIPLLPETRHLIGERELQLMKKSAYLVNASRGG 234 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D A EAL+ Q++ +DV+E E L + + + H Sbjct: 235 IVDETALYEALQTQQLAGAALDVFEEEPLH--------------MSPLFSLDSFIAMPHV 280 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGE 322 A T A+ ++S T + + + KG+ Sbjct: 281 AGYTPGAINTLSHTCVDQIIAVLKGK 306 >UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RMS7_ACIFE Length = 529 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 154/329 (46%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V ++ K ++ + E+ + E+ K +A+ + + Sbjct: 3 KKKVIVVERISDKGVEMLKAQPDLEVTVKFDIPREELLKIVGDYDAIIVRSVTKVNEEFY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + + +K + G +N+D++ A + G+ VV P + + AEH IG+M+ R Sbjct: 63 QAAR--NLKVVGRAGNGVDNIDIEGATKRGIIVVNTPEANVISAAEHTIGLMLASCRNTV 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAA 180 +A + + + L G +Y KT G+IG G+IG + + ++ F M+++A+DPY P + Sbjct: 121 KAQKMIESRVWDRKNLKGVELYHKTLGIIGLGRIGTLVTKRMQAFEMKVIAYDPYIPDSR 180 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LGVE + L L +++DVI++H P T E +++ + ++ K GV +VN +RG L + Sbjct: 181 FKRLGVEKCETLDDLLAKADVITIHTPKTEETINMIGKEELKKCKKGVRLVNCARGGLYN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA +A+K ++ S+G+DV +E L + T H Sbjct: 241 EQAVADAIKEGQVASIGLDVLVDEP--------------KPISPLIGLEQCVLTPHLGAD 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA + + Q + N+ G+ PN + Sbjct: 287 TVEAQDKVGISIAQEVVNVLNGQMVPNAV 315 >UniRef50_C4F960 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F960_9ACTN Length = 382 Score = 341 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 115/331 (34%), Positives = 186/331 (56%), Gaps = 5/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF--GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK+ V+ + ++ +V G E+ + LT T +G E V I Sbjct: 54 MKIKVFELRDDERAAYDRVVGELPAGCEVAWSADTLTSATLDMLDGAEGVVIVNKSPLDA 113 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +L EL GV+Y+A R GFN++D+DAAKELG+ V Y P VAE A+ +M+ R Sbjct: 114 DMLRELHDRGVRYVATRSIGFNHIDIDAAKELGIHVCNT-TYPPYGVAEFAVMLMLMALR 172 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 A R + ++SL GL G + T GV+GTG+IG A++ L+GFG ++LA+DP+PS Sbjct: 173 NYKPAMWRQQVNDYSLAGLRGRELRTLTVGVMGTGRIGRAVIDYLRGFGCKILAYDPFPS 232 Query: 179 AAALELG-VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 G V YV L L+++SD++++H PL +++ A +M++GV++VN SRG L Sbjct: 233 EELAARGDVTYVGLDELYAQSDLVTVHIPLMESTRGIIDCEAIAKMRDGVVLVNVSRGEL 292 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D A +E ++++KIG+L MDV+ E ++ +++D++ + L NV+ T H A Sbjct: 293 MDVDALVEGIESEKIGALAMDVFPEEDGIYHVSRTHDILANRNMAYLRQFPNVILTQHIA 352 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T + S+ + ++ + + GE CP EL Sbjct: 353 FYTDIDVDSMVEQGIRGILAMATGE-CPTEL 382 >UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID=C9MSC4_9BACT Length = 316 Score = 341 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 88/334 (26%), Positives = 149/334 (44%), Gaps = 24/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + L + ++ E + A + + I + + V Sbjct: 1 MKIVILDCHAVNPGDLSWEPIKQLADCTIYERTRQEDVVERAKDADGILI-NKVNITEEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++L K +KYI G+NN+D+ AA+ G+ V +PAY ++VA+H +++ R+ Sbjct: 60 LQQLPK--LKYIGELATGYNNIDIAAARARGVVVCNIPAYSTDSVAQHVFALLLNAATRV 117 Query: 121 HRAYQRTRDANFSL------EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 + R + + GKT G++G G IG + +I GM + A+ Sbjct: 118 DHYAEAVRRGEWCKQQDFCYWDTPLIELAGKTLGIVGLGHIGQKVAQIAHAMGMDISAY- 176 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 ++ L + L LFS SDVI+LHCPLT EN H++N ++M+ G +++NT R Sbjct: 177 TSKNSTDLPECIRKTTLEGLFSTSDVITLHCPLTAENAHMINAERLQKMRPGTILINTGR 236 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G LID QA +AL++ + + DV +E L N T Sbjct: 237 GGLIDEQAVADALESGHLKAYCADVMTDEPPRKDNP-------------LLQQPNAYITP 283 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H A+ T EA + ++N+ +G T N + Sbjct: 284 HVAWATREARERLMAIAVENIRKFIEG-TPQNCV 316 >UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Thermotogaceae RepID=A5IK90_THEP1 Length = 327 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 88/330 (26%), Positives = 148/330 (44%), Gaps = 28/330 (8%) Query: 1 MKLAVYSTKQYDKKYLQ--QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK + T+ + K + + + GFE+ D + + +A+ + + Sbjct: 1 MKKVLIVTRTFGKYSQEPVEFLKKEGFEIIRSDTIDPD----ILKEVDALIV-GTHPVTA 55 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 ++E +K IA G +N+DL+AA + G+ V + +VAE I + L R Sbjct: 56 EMIE---NSSLKVIAKHGVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALIR 112 Query: 119 RIHRAYQRT-RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + A+ + + + EG G + GKT GV+G G IG +++ GM +L +DPY Sbjct: 113 GLVWAHNKLFLERKW--EGTVGQEVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYV 170 Query: 178 SAAALEL-GVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 S + L VD L L ESD +SLH PL +++ E MK ++NTSRG Sbjct: 171 SKDNVRLLEATPVDDLDQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRG 230 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D +A ++ALK +I +DV+ E + L C N++ T H Sbjct: 231 GLVDEEALVKALKEGRIAGAALDVFSEEPP-------------NPNSPLFKCPNLITTAH 277 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCP 325 T E++ ++ Q++ + KG Sbjct: 278 IGAHTKESILRMNMMAAQSVVDFFKGNIPK 307 >UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales RepID=B1R2D5_CLOBU Length = 314 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 99/334 (29%), Positives = 158/334 (47%), Gaps = 25/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF---GFELEFFDFLL--TEKTAKTANGCEAVCIFVNDD 55 MKL++ +K+ + E E+ ++D + +E + + E + + N Sbjct: 1 MKLSILEPLGVEKEKFLNMAEKVLGDRVEITYYDNRVEDSETLIERSKDAE-IVVLSNFQ 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 + V+E+ +K I + G ++VD+D K+ G+ V Y AVA+ G+++ Sbjct: 60 YRKDVIEKCP--NLKMICVAFTGVDHVDIDYCKDRGITVCNCAGYSTVAVADLVFGLLIN 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + R I TR + GL GF + GK GVIGTG IG+ + I K FG + A+ Sbjct: 118 IYRNIVECNIVTRKGG-TKNGLVGFELEGKKFGVIGTGAIGMRVANIAKAFGCEVYAYSR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 ++YVDL TL S DVISLH PL L+NE + MK +++NT+RG Sbjct: 177 TVKEGKE---IKYVDLNTLLSTCDVISLHVPLNENTKGLINEENIKLMKKSAVLINTARG 233 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++DS+A +ALKN I G+DV+E E + V L N++ T H Sbjct: 234 PVVDSKALSDALKNNIIAGAGIDVFEIEPPI------------PVDHVLFDAPNLIVTPH 281 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AF T E++ ++ N+ G + N +V Sbjct: 282 VAFATKESMVKRAEIVFDNIDKYING-SSQNVIV 314 >UniRef50_Q036G7 Lactate dehydrogenase related 2-hydroxyacid dehydrogenase n=5 Tax=Lactobacillales RepID=Q036G7_LACC3 Length = 330 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 97/328 (29%), Positives = 166/328 (50%), Gaps = 2/328 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG-SRPV 60 K+ +Y+ + ++ + + +++ T A G + V I + V Sbjct: 3 KILMYTVRPDERAAIDAWVAANDIQVDTNTVEFGPDTVDLAKGYDGVVIQQHGAIPDEMV 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++LK G+K + LR G++ V+LDAA GL V VPAY P +V+E + +M L R + Sbjct: 63 YQKLKAFGIKQLTLRITGYDIVNLDAATANGLVVTNVPAYSPRSVSELVLAQVMRLIRHL 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A R ++SL GL ++ T G+IG GKIG A+ RI + G ++ DP Sbjct: 123 GEASAREAKDDYSLAGLEAPEIHNLTVGIIGAGKIGSAVARIFRALGATVIVSDPVKRPE 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + V YVDL TL + SDV+++H PL HL++ A +MK ++N +RG ++D+ Sbjct: 183 LADT-VSYVDLNTLLTTSDVVTVHTPLDGLTTHLIDADALRKMKPTAYLINAARGPIVDT 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A I+AL + I +D E E +F ED+S ++ + L A NV + H F T Sbjct: 242 EALIKALNDHTIAGAALDTIEGEAGIFGEDRSQTLVDNQALETLKAMPNVEISPHIGFYT 301 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++ +L ++ + +G +++ Sbjct: 302 DAAVKNMIDISLDDVKTILEGGKSAHQV 329 >UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desulfuromonadales RepID=A5GES6_GEOUR Length = 541 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 90/329 (27%), Positives = 155/329 (47%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T + ++ L+ + + EL+ L E+ E + + + Sbjct: 1 MKVIV--TDEVAQEGLELLKQDPRVELDIRLGLKKEELLAIIGDYEVIITRSGTTVDKDL 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ KK +K +A G +NVD+D A G+ VV P + + AEHA+ ++++ R I Sbjct: 59 LDAGKK--LKMVARAGVGIDNVDIDYASSKGVIVVNAPFGNTNSAAEHAMALLLSFCRNI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-A 179 +A + + TG + GKTAGVIG GK+G + LK F +L DPY + Sbjct: 117 TKANASLKSGEWKRAPFTGVELKGKTAGVIGLGKVGGRVATRLKAFECDVLGCDPYIAVK 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +LGV+ V ++ D+I+ H PL E +++ E MK+GV+++N +RG +I+ Sbjct: 177 RAHDLGVKLVSHEEIYKNCDIITFHTPLNEETRNMVGEKEIAMMKDGVILINAARGGIIN 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA + ALK K+ MDV+ E + + + L + ++ T H Sbjct: 237 EQALLNALKGGKVFGAAMDVWSEEPP-----------KSETLKELISQDKLVVTPHLGAN 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ + + N + N + Sbjct: 286 TFEAQINVAVDVSKEILNYLDEQPLENAV 314 >UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermotoga naphthophila RKU-10 RepID=D2C7W6_THENR Length = 329 Score = 340 bits (873), Expect = 4e-92, Method: Composition-based stats. Identities = 92/330 (27%), Positives = 150/330 (45%), Gaps = 26/330 (7%) Query: 1 MKLAVYSTKQYDK--KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M+ V +T+ + + K E GF + + E+ + EA+ + +R Sbjct: 1 MRKVVVATRTFGRYTKEPIDYLERNGFVVLRVEK--EEELREAIKDAEALIV-GTHTVTR 57 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 ++E +K IA G +N+D++AA E G+ V + +VAE I + L+R Sbjct: 58 EMIE---SSNLKVIAKHGVGVDNIDVEAATEKGIPVTITLGANSLSVAELTIAFIFALSR 114 Query: 119 RIHRAYQRT-RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + A+ + + + EG G + GK GVIG G IG +++ GM +L +DPY Sbjct: 115 GLIWAHNKLFYEKKW--EGYVGQEVSGKVMGVIGFGSIGREVVKKAVCLGMNVLVYDPYV 172 Query: 178 SAAALEL-GVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 S ++ L VD L L ESD +SLH PL +++ E MK ++NTSRG Sbjct: 173 SKDSVRLLEATPVDDLEQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRG 232 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D +A ++ALK +I +DV+ E D L C N++ T H Sbjct: 233 ELVDEEALVKALKEGRIAGAALDVFSEEPP-------------DANSPLFECPNLITTAH 279 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCP 325 T EA+ ++ Q++ + KG Sbjct: 280 IGAHTKEAIFRMNMMAAQSIVDFFKGRIPR 309 >UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0DAP4_9CLOT Length = 320 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 94/330 (28%), Positives = 153/330 (46%), Gaps = 18/330 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + + +++ E GFEL + +A+ I D R V Sbjct: 1 MRVVITDYQYDNVDAERRLVEGAGFELLDYQVKTPGALIPLVKDADAI-ITQYADIDRQV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E L+ K I G NN+D AA E G+ V VP Y V++ A+ M++ L +++ Sbjct: 60 IESLEH--CKMIIKYGIGVNNIDCRAAGEKGIYVCNVPDYGVHEVSDQAVTMILCLGKKL 117 Query: 121 HRAYQRTRDANFSLEGLTGF-TMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + R + G+ AG+IG G+I + R L+ FGM +L +DP+ Sbjct: 118 EPLQEDLRRGKWGYGGIVPVKRFTECKAGLIGFGRIPQMVCRKLQAFGMEILVYDPFVDD 177 Query: 180 AALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A +E G + + +D IS+HCPLT E H++ E F MK IVNT+RG ++ Sbjct: 178 AVIEAAGAVRASVEEICRNADFISVHCPLTEETRHMIGEKEFAMMKPECCIVNTARGGVV 237 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D QA I AL +I G+DV+E E V+ L NV+ T H A+ Sbjct: 238 DEQALIGALNEGRIAGAGVDVFEEEPV-------------SVYHPLLHMENVIATPHSAW 284 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + A+T++ + + + N+ +G N + Sbjct: 285 YSETAITTLQRKAAEEVVNVLQGNEPMNCV 314 >UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SGT4_9BACT Length = 544 Score = 340 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 84/329 (25%), Positives = 151/329 (45%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V T + + + E++ + K +A+ + ++ Sbjct: 3 KYKVLITDHISQDGVNILKSDKDIEVDIQAGIKNPDLKKIIGNYDAIITRSGTTVTAELI 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E K +K I G +NVD++AA G+ V+ P + A E +GMM+++ R++ Sbjct: 63 ENPGK--LKIIGRAGVGLDNVDIEAASMKGIIVMNAPTGNTLAACELTMGMMLSVVRKLP 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 A Q T+ + + G +Y KT V+G G+IG + + K F M+++A+DPY + Sbjct: 121 LANQVTKSGEWDRKRFMGIQLYQKTLAVVGLGRIGGNVAKRCKAFDMKVVAYDPYIKKSR 180 Query: 182 LE-LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E LGVE L S++D+I+ H PLT E +L+ + +MK+GV+I+N +RG +++ Sbjct: 181 AESLGVELCNSLEEAISQADIITFHTPLTDETKNLITKDEIAKMKDGVVIINCARGGIVN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A K+ K+ + G+DV+ +E V N+ T H Sbjct: 241 ELDLVDACKSGKVTAAGLDVFMSEP--------------PVNHPFFDVENIYVTPHIGAN 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAE ++ + + N G + N + Sbjct: 287 TAEGQYGVAVIIAEQVVNALHGRSYKNAV 315 >UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG7H23 RepID=B3T9W6_9ZZZZ Length = 491 Score = 340 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 87/283 (30%), Positives = 135/283 (47%), Gaps = 17/283 (6%) Query: 40 KTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA 99 + G EA+ + + ++E ++ I G +NVDLDAA G+ VV P Sbjct: 3 EIIGGYEALIVRSETQVTAGLIEAGGH--LQVIGRAGVGVDNVDLDAATRQGIPVVNAPT 60 Query: 100 YDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAM 159 + A AEH + +M+ + R I +A R + G + GK G+IG GK+G + Sbjct: 61 GNTVAAAEHTLALMLAMVRHIPQADASVRMGEWRRSAFMGVEVRGKILGIIGLGKVGSEV 120 Query: 160 LRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEA 218 R + MR+LA DP+ P +A LGVE V L L +E+D I++H PLT LL A Sbjct: 121 ARRTRALQMRILAHDPFVPQESARSLGVEMVSLDQLMAEADFITIHTPLTATTQQLLGPA 180 Query: 219 AFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQD 278 F+Q+K+GV I+N +RG L++ Q +EAL++ ++ +DV+ E Sbjct: 181 QFQQLKHGVRIINAARGGLVNEQLLLEALESGRVAGAALDVFVEEPPKQ----------- 229 Query: 279 DVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 L V+ T H T EA T ++ + + G Sbjct: 230 ---SPLLQHPRVVLTPHLGASTEEAQTEVALEIADQVLAVLAG 269 >UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WI96_EGGLE Length = 526 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 93/330 (28%), Positives = 156/330 (47%), Gaps = 19/330 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V T++ + L V G E++ + E+ +T G +A+ + + V Sbjct: 1 MTKKVLVTERLAEAGL-AVLRDKGCEVDVKLKMTPEELIETVPGYDALIVRSATKVTAEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E + ++ I G +NVD++AA E G+ V P + + AEHAIG+M+ R++ Sbjct: 60 VEAADR--LRIIGRAGVGVDNVDVEAATEHGIIVCNAPTSNIVSAAEHAIGLMLACARKV 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + + TG +Y KT + G G+IG + + FGM+L+ +DPY S Sbjct: 118 PQANASMHEGVWERGKYTGVELYEKTLAIFGLGRIGGLVAERARAFGMKLIGYDPYCSPE 177 Query: 181 -ALELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A +LGV Y D+ L +D I++H P T E + + +MK+GV++VN +RG + Sbjct: 178 RAEQLGVTLYDDVDALVPLADFITVHLPKTKETIGMFGPDQYARMKDGVILVNAARGGIF 237 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D ++ + L KIG++G+DV+E+E L N + T H A Sbjct: 238 DEKSLADFLAAGKIGAVGIDVHESEPCTD--------------SPLREFDNAILTPHIAA 283 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA T + ++ +G P L Sbjct: 284 STQEAQLRAGVQTAEYVAAGLEGSIVPTAL 313 >UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacteria RepID=B2IJN8_BEII9 Length = 529 Score = 339 bits (870), Expect = 9e-92, Method: Composition-based stats. Identities = 87/314 (27%), Positives = 143/314 (45%), Gaps = 19/314 (6%) Query: 18 QVNESFGFELEFFDFL--LTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALR 75 + + G E++F L +K A+ + + I + +LE K +K + Sbjct: 17 AIFKERGIEVDFQPDLGKDKDKLAEIIGQFDGLAIRSATKVTDKILE--KATNLKVVGRA 74 Query: 76 CAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE 135 G +NVD+ AA G+ V+ P + AEHAI +M L R+I A T+ + Sbjct: 75 GIGVDNVDIPAATAKGVIVMNTPFGNSITTAEHAIALMFALARQIPSADASTQAGKWEKN 134 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTL 194 G + K G+IG G IG + G MR++AFDP+ + AL+LGVE V+L L Sbjct: 135 KFMGVEITAKVLGIIGCGNIGSIVAERGVGLKMRVIAFDPFLTPERALDLGVEKVELDDL 194 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 + +D I+LH PLTP+ ++L+ + K GV ++N +RG L+D +A + L + + Sbjct: 195 LARADFITLHTPLTPQTKNILSAENLAKTKKGVRVINCARGGLVDEEALRKLLDSGHVAG 254 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 DV+ E L NV+ T H T+EA +++ + Sbjct: 255 AAFDVFITEPAKE--------------NPLFGHPNVVCTPHLGASTSEAQENVALQVAEQ 300 Query: 315 LSNLEKGETCPNEL 328 +S+ N + Sbjct: 301 MSDYLTRGAISNAV 314 >UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Archaea RepID=A8A9G4_IGNH4 Length = 308 Score = 338 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 103/318 (32%), Positives = 157/318 (49%), Gaps = 19/318 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFEL-EFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 T + L+ + E G E+ E + E + G + + + R V+E Sbjct: 4 ALVTDKVHPAGLELLREK-GIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVIEA 62 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K +K IA +G +N+DL+AAKE G+KVV P AVAE IGMM+ L RR H + Sbjct: 63 ADK--LKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYS 120 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-SAAAL 182 Y++ + + E + GF + GKT GV+G G+IG + + K GM ++A+D S A Sbjct: 121 YRKLLEGEW--EKVMGFELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAK 178 Query: 183 ELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 E+GVE+ DL L +SDV+SLH PLT + +++N + MK+G +++N +RG + D Sbjct: 179 EMGVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYS 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +EAL++ K+ +G+DVY E E +L T H T Sbjct: 239 ALLEALESGKLWGVGLDVYPEEPPKSEE-----------LLKLIRHPRTFATAHIGAQTE 287 Query: 302 EALTSISQTTLQNLSNLE 319 EA S Q + Sbjct: 288 EAQRRTSLEVAQRILEAL 305 >UniRef50_Q47748 D-specific alpha-keto acid dehydrogenase n=50 Tax=Bacteria RepID=VANH_ENTFA Length = 323 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 102/320 (31%), Positives = 165/320 (51%), Gaps = 6/320 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V+ +Q + + ++ F ++ AK A G + + + + S Sbjct: 5 MGITVFGCEQDEANAFRTLSPDFHIIPTLISDAISADNAKLAAGNQCISVGHKSEVSEAT 64 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + L+K GVKYI+ R G N++D AA+ +G+ V V AY P++VA++A+ +M+ R Sbjct: 65 ILALRKVGVKYISTRSIGCNHIDTTAAERMGISVGTV-AYSPDSVADYALMLMLMAIRGA 123 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 NF L+ + G + T GVIGTG IG A+++ L+GFG R+LA+D Sbjct: 124 KSTIHAVAQQNFRLDCVRGKELRDMTVGVIGTGHIGQAVVKRLRGFGCRVLAYDNSRKIE 183 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A YV L L SD+++LH PL + HL+ + +MK G ++NT RGAL+D+ Sbjct: 184 AD-----YVQLDELLKNSDIVTLHVPLCADTRHLIGQRQIGEMKQGAFLINTGRGALVDT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + +EAL + K+G +DV E E + D S V+ +L NV+ T H A+ T Sbjct: 239 GSLVEALGSGKLGGAALDVLEGEDQFVYTDCSQKVLDHPFLSQLLRMPNVIITPHTAYYT 298 Query: 301 AEALTSISQTTLQNLSNLEK 320 L ++ T++N N E+ Sbjct: 299 ERVLRDTTEKTIRNCLNFER 318 >UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HQU2_9FIRM Length = 324 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 74/291 (25%), Positives = 122/291 (41%), Gaps = 17/291 (5%) Query: 40 KTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA 99 + E + + +L + ++ IA G++NVD+ A G+ P Sbjct: 42 EWLADAEGLVSTGDVRVDDELLAHAPR--LRVIAQASVGYDNVDIAACTRRGIPFGNTPG 99 Query: 100 YDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANF--SLEGLTGFTMYGKTAGVIGTGKIGV 157 EA A+ G+++ RRIH + + + + + G +YGKT G++G G+IG Sbjct: 100 VLVEATADLTFGLLLCAARRIHEGWNQVASGRWLNNHDVPFGIDLYGKTLGIVGMGRIGA 159 Query: 158 AMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNE 217 A+ R K GM+++ + LG YV L +++D I + PL+P + + Sbjct: 160 AVARRAKACGMKVIYHNRSRRTDDEHLGATYVAFDDLLAQADCIVVLVPLSPASQGMFGR 219 Query: 218 AAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQ 277 A F +MK +N +RG L+D+QA +ALK +I +DV + E Sbjct: 220 AEFAKMKRTAYFINAARGGLVDTQALYDALKEGQIAYAALDVTDPEPL------------ 267 Query: 278 DDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 L NVL T H T E ++ T NL P + Sbjct: 268 -PGDHPLLTLPNVLITPHIGSATHETRDRMAMLTADNLLAGLARRPLPACV 317 >UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepID=A9A5A9_NITMS Length = 322 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 80/331 (24%), Positives = 149/331 (45%), Gaps = 22/331 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTE-KTAKTANGCEAVCIFVNDDGSRP 59 M+ V+ T+ L+++ + + E+ + + K + + F D ++ Sbjct: 1 MRKKVFLTRTLHDFALKELKKKYQIEVHKGKIPVPQSKLRSKIKDVDGLICFPYDIINKE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 ++ + +K I+ GF+++D AK ++V P +A A+ A +++ RR Sbjct: 61 TIDLAE--NLKVISTYSVGFDHIDTKYAKGKKIRVGYTPEVLTDATADLAFSLLLDSLRR 118 Query: 120 IHRAYQRTRDANFSL----EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + + RD + + G + GKT G++G G+IG + + K F M ++ + Sbjct: 119 VSEGDRIIRDGKWKMIYGAHDYVGVDLQGKTIGILGLGRIGQTLAKRAKAFDMDIIYHNR 178 Query: 176 YPSAAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + E L +YV L S+SDVIS+H P T E + N F++MKN ++NTS Sbjct: 179 NRLSKTKERTLDAKYVSFERLISQSDVISIHVPHTKETDKMFNMKIFKKMKNTAFLINTS 238 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +++ + + ALK + I G+DV+E E L+ NV+ Sbjct: 239 RGKVVNEKDLVTALKKKIIAGAGLDVFEQEPISKN-------------HPLTKLQNVVLA 285 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 H T E +++ T++NL+ G+ Sbjct: 286 PHIGSSTKETRAKMAEITVRNLNLGMNGKKP 316 >UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7SFV8_NEMVE Length = 487 Score = 336 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 136/308 (44%), Gaps = 15/308 (4%) Query: 17 QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 + + E G ++ L E+ + + + S V++ K +K I Sbjct: 20 KTILERNGVTVDVNTKLSKEELVSEIPKYDGLIVRSATKVSEDVIKAGK--NLKIIGRAG 77 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG 136 G +N+D AA G+ V+ P + + AEH ++ +L R I +A T++ + + Sbjct: 78 TGVDNIDTVAASLHGVLVMNTPGGNTLSAAEHTCALISSLARHIPQASASTKEGKWERKQ 137 Query: 137 LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVEYVDLPTLF 195 G ++GKT +IG G+IG + ++ +G++ + +DP S A E +E+++ ++ Sbjct: 138 FMGNELFGKTLAIIGLGRIGREVALRMQSYGVKTIGYDPLVSPQDAAESNIEWMETEKIW 197 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 +D I++H PL P +LN+ K GV I+N +RG +ID +A + L++ +G Sbjct: 198 PLADYITVHVPLIPPTKGMLNDKTIGMCKKGVYILNVARGGIIDEEALLRGLESGHVGGA 257 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 G+DV+ E L V+ H T EA ++Q Sbjct: 258 GLDVFVTEPPTGSS------------ADLVKHPKVIACPHLGASTEEAQRRVAQEIADQF 305 Query: 316 SNLEKGET 323 + G+ Sbjct: 306 VDGMNGKP 313 >UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cellular organisms RepID=B7KZ64_METC4 Length = 535 Score = 336 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 143/314 (45%), Gaps = 19/314 (6%) Query: 18 QVNESFGFELEFFDFL--LTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALR 75 Q+ G E++F L E A + + I + +L + + +K I Sbjct: 23 QIFRDRGIEVDFQPGLGKDKEALAAIIGQYDGLAIRSATKVTDKLLAQATR--LKVIGRA 80 Query: 76 CAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE 135 G + +D+ AA G+ V+ P + AEHAI ++ L R+I A T+ + Sbjct: 81 GIGVDTIDVPAATARGVIVMNTPFGNSITTAEHAIALIFALARQIPAADASTQAGKWEKN 140 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTL 194 G + KT GV+G G IG + G ++++A+DP+ + A E+GVE V+L L Sbjct: 141 RFMGVELTAKTLGVVGCGNIGAVVADRAIGLKLKVIAYDPFLTPERAFEIGVEKVELDEL 200 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 + +D+I+LH PLT + +LL+E + K GV IVN +RG L+D A AL++ + Sbjct: 201 LARADIITLHVPLTDKTRNLLSEENLAKTKRGVRIVNCARGGLVDEIALRAALESGHVAG 260 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 +DV+ E + L NV+ T H T+EA +++ + Sbjct: 261 AALDVFVTEPAIE--------------NPLFGHPNVICTPHLGAATSEAQENVALQIAEQ 306 Query: 315 LSNLEKGETCPNEL 328 +++ N + Sbjct: 307 MADYLLSGAITNAI 320 >UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MD25_CALMQ Length = 326 Score = 336 bits (862), Expect = 7e-91, Method: Composition-based stats. Identities = 105/335 (31%), Positives = 159/335 (47%), Gaps = 30/335 (8%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFD-----------FLLTEKTAKTANGCEAVCIFVN 53 +Y T+ K L + GF+LE +D + A+ C+A+ + + Sbjct: 1 MYLTRSTFPKLLYDTLRNAGFDLEVWDNKGHGMWDRAAAPPRDVLRDAASRCDALVVTIG 60 Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 D VL K VK IA G++++DLDAA G+ V P EAVA+ AIG++ Sbjct: 61 DRVDDYVLSNAK---VKVIATYSVGYDHIDLDAATRRGIPVGYTPEVLVEAVADLAIGLI 117 Query: 114 MTLNRRIHRAYQRTRDAN-FSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 +TL RR+ + R + + G G ++GKT G++G G IG A+ R K F M ++ Sbjct: 118 ITLARRVIEGDRLVRSGEAYKVWGEFLGTEVWGKTLGILGLGNIGAAVARRAKAFNMNVI 177 Query: 172 AFDPYPSA-AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + + LG+ YVDL LF +SD + L L+ E YH++NE MKN +V Sbjct: 178 YWSRTRKPWIEVALGLRYVDLNELFRQSDYLVLTVALSKETYHIVNEERLRLMKNTSYLV 237 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RGA++D+ A ++ALK I +DVYE E L +NV Sbjct: 238 NVARGAVVDTNALVKALKEGWIAGAALDVYEEEPI-------------PNTHELIKLNNV 284 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 + T H A T E +++ T N+ N+ T P Sbjct: 285 ILTPHIASATVETRNKMAEVTALNVINVLLKNTKP 319 >UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Staphylococcus RepID=Q5HNI1_STAEQ Length = 531 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 79/329 (24%), Positives = 154/329 (46%), Gaps = 17/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + + + LQ + + F+++ L + +A+ + + + Sbjct: 1 MSHKILVSDPISEDGLQSILKHPEFDVDIQTDLSENDLVNMISTYDALIVRSQTQVTERI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +K IA G +N++++AA G+ V+ P + + EH++ M++ + R I Sbjct: 61 INAA--TNLKVIARAGVGVDNINIEAATLKGILVINAPDGNTISATEHSVAMLLAMARNI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+Q R+ ++ + G +YGKT GVIG G+IG+ + + + FGM++LAFDPY + Sbjct: 119 PQAHQSLRNKEWNRKAFRGVELYGKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTED 178 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A L ++ + + +SD +++H PLTP+ ++ + F + K + I+N +RG +ID Sbjct: 179 KAKSLDIQIATVDEIAEKSDFVTVHTPLTPKTRGIVGSSFFNKAKQNLQIINVARGGIID 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A IEAL N I +DV+E+E L ++ T H Sbjct: 239 ETALIEALDNNLIDRAAIDVFEHEPPTD--------------SPLIQHDKIIVTPHLGAS 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ + + + + + + Sbjct: 285 TVEAQEKVAVSVSEEIIEILTKGNVEHAV 313 >UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brachyspira RepID=C0QYX0_BRAHW Length = 534 Score = 336 bits (862), Expect = 9e-91, Method: Composition-based stats. Identities = 81/305 (26%), Positives = 146/305 (47%), Gaps = 15/305 (4%) Query: 26 ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLD 85 E F + ++ K +A+ + +R ++E K +K I G +N+D++ Sbjct: 22 EAVFLPTMSEDELVKVIGEYDALMVRSQTKVTRKIIEAGK--NLKIIGRAGVGVDNIDVE 79 Query: 86 AAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGK 145 AA E G+ VV P + A +EH I +M+ ++R I A T++A ++ + TG + GK Sbjct: 80 AATEKGIIVVNSPDGNTIAASEHTIALMLAVSRNIVPAAVSTKEAKWNRDKFTGNELLGK 139 Query: 146 TAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEY-VDLPTLFSESDVISL 203 T GV+G G+IG ++ I GM+++ +DP+ + + G Y L + D +SL Sbjct: 140 TLGVMGFGRIGRKVVHIALAIGMKVIVYDPFATEEIVQKAGAVYETSLDEFLPKLDYLSL 199 Query: 204 HCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 H P TPE +++N+ +MKN +I+N SRG L++ + AL+N I + +DV+ NE Sbjct: 200 HIPKTPETNNIINKDNLCKMKNTAIIINCSRGGLVNEEDLKNALENGTIAAAAVDVFVNE 259 Query: 264 RDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGET 323 + N++ T H T EA +++ + + + G Sbjct: 260 PKIETCPLVE-----------YKKDNLILTPHLGASTKEAQINVALDVAKQIKQVLSGGY 308 Query: 324 CPNEL 328 + + Sbjct: 309 TESAV 313 >UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0P693_9FIRM Length = 322 Score = 335 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 91/314 (28%), Positives = 154/314 (49%), Gaps = 18/314 (5%) Query: 17 QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 +++ G EL + ++ A C+A+ + V+ + + K I Sbjct: 20 REIIRQAGGELFDYHCATEDEVISAAADCDALIC-QFAPITARVIRAMPR--CKVIVRYA 76 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG 136 G +N+DL AA+E G+ V VP Y + V+ HAI ++M +++ + + S Sbjct: 77 IGVDNIDLKAAEEQGVYVCNVPDYSIDEVSNHAIALLMDCVKKLTFLASQVKAGRSSYTV 136 Query: 137 LTG-FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVEYVDLPTL 194 + M G T G++G G+I + + + GFG++++A+DP AA ELGV V L Sbjct: 137 VKPLHRMQGSTLGLMGFGRIPRLVAQKMAGFGLKMIAYDPMLDQQAAQELGVTPVSFEQL 196 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 +SD +S+HCPL H+ N+ AF MK ++VNT+RGA++D QA I+AL + +I Sbjct: 197 LMDSDYLSIHCPLNESTRHIFNQEAFRLMKPTAVLVNTARGAVVDEQALIQALSDGQIAM 256 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 G+DV E E L N + T H A+ + EA+ S+ + + Sbjct: 257 AGLDVTEQEPVAADNP-------------LLKLDNAVVTPHAAWYSEEAVASLQRKVAEE 303 Query: 315 LSNLEKGETCPNEL 328 ++ + +GET N + Sbjct: 304 VARVLRGETPQNPV 317 >UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacteria RepID=Q0B0Y6_SYNWW Length = 530 Score = 335 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 79/309 (25%), Positives = 143/309 (46%), Gaps = 18/309 (5%) Query: 22 SFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNN 81 E+++ D + E+ + + +A+ + ++ K+ +K + G +N Sbjct: 21 KTELEVDYRDGISREELLEIIDQYDALIVRSVTQVDEELIRRAKR--LKIVGRAGNGIDN 78 Query: 82 VDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFT 141 +D+D G+ V P + + AE I ++++ R A + + + + G Sbjct: 79 IDVDVCTRYGVIVANTPDSNTISAAEQTISLLLSSIRNTAWASEYLKGGTWDRKPFRGVE 138 Query: 142 MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL-ELGVEYV-DLPTLFSESD 199 +YGKT G++G G+IG + LK F MR++A+DPY S G E + L L E+D Sbjct: 139 LYGKTVGIVGLGRIGSMVATRLKAFNMRVIAYDPYISDERFTRFGAEKMESLEELVKEAD 198 Query: 200 VISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDV 259 I++H P E H+++E K GV +VN +RG +I +A ++ L+++K+ S G+DV Sbjct: 199 FITVHTPRNEETMHMIDERILGLAKEGVRVVNCARGGIIKEEALLKGLESKKVLSAGLDV 258 Query: 260 YENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLE 319 +E E + L +V+ T H T EA + + + + Sbjct: 259 FEKEPAID--------------NPLFQFKSVVVTPHLGADTFEAQKRVGENIAEQVIKAL 304 Query: 320 KGETCPNEL 328 KGE PN + Sbjct: 305 KGEIVPNLV 313 >UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=29 Tax=Clostridiaceae RepID=B1KZ88_CLOBM Length = 314 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 87/318 (27%), Positives = 142/318 (44%), Gaps = 17/318 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + + +K L ++NE GF + E+ +A+ I + +++ Sbjct: 2 IKILVSDGMEKNALNKLNEQ-GF-VVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIID 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K + G +NVDL+ AKE G+KV P +VAE +G M+ ++R I+ Sbjct: 60 AGIKGNLKLVVRAGVGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINT 119 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A + + G +YGKT G+IG G+I + + GM ++ +D Sbjct: 120 ANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEEY 179 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E + L L + SD IS+H P + LL E F +MK+GV IVN +RG +I+ +A Sbjct: 180 EE-FKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIVNCARGGVIEEEA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 ++AL N K+ + +DV+ENE + + L V T H T E Sbjct: 239 LLKALNNGKVTAAALDVFENEP--------------EPKKELINHERVSITPHIGASTKE 284 Query: 303 ALTSISQTTLQNLSNLEK 320 A I + + L N Sbjct: 285 AQMRIGEEIVDILDNFFN 302 >UniRef50_C0WS24 D-lactate dehydrogenase n=6 Tax=Lactobacillus RepID=C0WS24_LACBU Length = 339 Score = 334 bits (858), Expect = 3e-90, Method: Composition-based stats. Identities = 92/332 (27%), Positives = 170/332 (51%), Gaps = 6/332 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGS--R 58 K+ Y+ Y+++++ + +++F L + T A G + + + Sbjct: 7 KILAYNILDYEREFVVEWAAEHPDVQVDFNSIELHDDTVHLAEGYDGIDYRQRSQLTDGS 66 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 + ++L +G+ +ALR AG ++ +L AKE GL V VP+Y P AVAE + M L R Sbjct: 67 DLYKKLHDYGIHQLALRSAGVDSCNLKYAKENGLTVTNVPSYSPRAVAEMTLTHAMNLIR 126 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR-LLAFDPYP 177 I + +R R ++ + GL + T G+IG G+IG + +I K G + +L D Sbjct: 127 HIPQFQKRIRQNDYVVNGLRSKEISNLTVGIIGVGRIGSTVAKIFKALGAKRVLGNDIKE 186 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + +L V+Y ++ +D+I++H ++ +NYH++ + F +MKN + +N SRG + Sbjct: 187 NDDFRDL-VDYTTKEDIYKNADLITMHTYMSDQNYHMIGKDQFGKMKNTALFINCSRGPI 245 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDK-SNDVIQDDVFRRLSACHNVLFTGHQ 296 +D+ A + AL+ +I G+DV ++E +F + D I V+ +L NV T H Sbjct: 246 VDTDALVNALETGQIAGAGIDVIQDETKIFNQSFIGEDKIPLPVYTKLMNMDNVFLTPHV 305 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 AF T A+ ++ + +L + G+ P+ + Sbjct: 306 AFYTDHAVKNMVKQSLDDTLMEISGKESPHRI 337 >UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B6KF90_TOXGO Length = 604 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 147/325 (45%), Gaps = 13/325 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V D+ + ++ + + L E+ + + + + + +++ Sbjct: 18 VLVCDPIDQAGMDILSSFADVDTKL--KLSEEELCRVVGNYDGLMVRSGTTVTEKIIKHG 75 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K +K I G +NV +DAA G+ VV P + A AE +G+MM L R+I +A Sbjct: 76 QK--LKIIGRAGVGVDNVCVDAATAQGIFVVNSPNGNTMAAAELTLGLMMALARKIPQAD 133 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 ++ G + KT G+IG G++G + R+ GM +LA+DP+ + A Sbjct: 134 ASVSRGEWTRSKFMGRQLNQKTIGIIGLGQVGTHVARVCTALGMEVLAYDPFINEEKAKA 193 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 +G V L TL + SD I+LH PL + HL+N + +K I+N SRG +ID +A Sbjct: 194 VGCRNVALETLLASSDFITLHVPLLDKTRHLINADKLKLIKKDACIINASRGGVIDEKAV 253 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 EAL ++ +DV+E E++ K N +IQ R N++ T H T EA Sbjct: 254 AEALMANELAGAALDVFEEEKEF---SKDNPLIQAKANGR-----NIILTPHIGASTLEA 305 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ G + + Sbjct: 306 QHNVAVDVALQFREALLGGLPQSAV 330 >UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R855_9PLAN Length = 542 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 145/326 (44%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + ++ L + + G E E L E+ K+ + + LE Sbjct: 4 ILILDPIAQEGLDMLAAAPGIEYEVRTGLKGEELKKSLAEFDGAICRSGVTITAESLE-- 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ IA G +N+D +AA LG+ V+ P + + AEH +M+ L+RR+ AY Sbjct: 62 GNRRMRAIARAGVGTDNIDKNAATRLGIVVMNTPTGNTLSTAEHTFTLMLALSRRVAEAY 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + + + G + KT G++G G+IG + + F M++L FDP+ S A + Sbjct: 122 HKLIGGKWDRKTFMGTQLADKTLGIVGLGRIGQEVAKRAIAFQMKVLGFDPFLSTEQAAK 181 Query: 184 LGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 LG+E V+ + + D +++H PLTPE +L+ E +K GV ++N +RG + + A Sbjct: 182 LGIERVETVQEMLPRVDYLTVHTPLTPETTNLVGFPELEVLKPGVRLINCARGGIYNEDA 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +E LK KIG + +DV+ E + NVL T H T E Sbjct: 242 LVEGLKTGKIGGVALDVFVTEPCDK--------------HPIYGMPNVLCTPHLGASTEE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ +Q L N + + Sbjct: 288 AQQQVAIEAVQLLINFFTTGEVRHAV 313 >UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1K3M3_DESAC Length = 528 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 89/327 (27%), Positives = 141/327 (43%), Gaps = 16/327 (4%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V + + L+ +E+ G ++ + + K N +A+ + S ++ Sbjct: 1 MQVLISDNFSSAGLKLFDEAEGITADYQPGITHDNLLKIINNYDALIVRGGTTVSEELIF 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K+ +K IA G N+ +DAA G+ V P +AEHAI MMM+L R I + Sbjct: 61 AAKR--LKIIARAGIGVENIAMDAANIKGIVVTNTPLGSTTTIAEHAIAMMMSLARLIPQ 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A++ + G + KT GVIG GKIG ++ +G M + +DPY S + Sbjct: 119 AHESMSQGKWQSTEFLGSDINDKTLGVIGGGKIGRRVIEYARGLHMHVNLYDPYLSEEVI 178 Query: 183 -ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LG V L L S +D ISLH PLT E +LN F +K G ++N + G LI+ Sbjct: 179 TRLGASKVSLEDLLSTADFISLHLPLTLETEQILNAETFAMVKPGCRLINCALGGLINED 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 + AL + +D + E RL NV+ T H T Sbjct: 239 DLVNALTDGTFAGAALDTFATEPPA-------------PDNRLLHMDNVICTPHLRAATV 285 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 +A T+++ + + +T N L Sbjct: 286 DAQTNVTVQAAHQVIDFLTNKTVRNAL 312 >UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clostridia RepID=B8I0H1_CLOCE Length = 535 Score = 333 bits (854), Expect = 8e-90, Method: Composition-based stats. Identities = 93/328 (28%), Positives = 155/328 (47%), Gaps = 15/328 (4%) Query: 1 MKLAVYS-TKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V + YL + G E++ + E+ +T +A+ + + Sbjct: 1 MKIIVTERIAEDGINYL----KENGHEVDTRYGISHEELLETIEDYDAIIVRSVTKVNEE 56 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +L+ K +K G +N+++ A + G+ VV P + A AE A+G + R Sbjct: 57 LLQRASK--LKVAGRAGNGIDNIEVPACTKRGIIVVNTPESNIMAAAELAVGHAYAIFRN 114 Query: 120 IHRAYQRTR-DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 I +A+ + +F G + KTAG+IG G+IG + LKG M+++A+DPY + Sbjct: 115 IPQAHWAGKAQNDFRRSRFNGNELDEKTAGIIGLGRIGSIVATKLKGSNMKVIAYDPYIT 174 Query: 179 AAA-LELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 +LGVE D L L +SD+ISLH P T E Y ++ E + K V IVN +RG Sbjct: 175 DEKFKKLGVERCDTLEELLKQSDLISLHTPKTSETYGMIGEEQLKLCKKDVRIVNAARGG 234 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L++ +A A+K + + +DV + E + + + D +L NV+ T H Sbjct: 235 LVNEEALYNAIKEGHVAAAALDVLDPEPNYDKKPEDQ-----DYQNKLFELDNVIITPHL 289 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETC 324 TAEA ++ + +S+ KGE Sbjct: 290 GASTAEANYNVGTAVSKLVSDALKGEMV 317 >UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBM0_9FIRM Length = 529 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 87/313 (27%), Positives = 149/313 (47%), Gaps = 20/313 (6%) Query: 18 QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCA 77 + ++ ++F + E + +A+ + + + + KK +K I Sbjct: 21 KAEKALDVTVDF--DIKREDLLQVIGNYDALIVRSVTKVNEELYDAAKK--LKVIGRAGN 76 Query: 78 GFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGL 137 G +N+DLD A + G+ VV P + + AEH IG+++ R RA + + + + L Sbjct: 77 GVDNIDLDGATKRGIIVVNTPEANIISAAEHTIGLLLASCRNTVRANKMLEEGIWERKDL 136 Query: 138 TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYVD-LPTLF 195 G +Y KT G+IG G+IG + + + F MR++A+DPY P + LGVE + L L Sbjct: 137 KGSELYHKTLGIIGLGRIGALVTKRMHAFDMRVIAYDPYIPDSRFQRLGVEKCETLDDLL 196 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 E+DVI++H P T E ++L A +++ K GV +VN +RG L + Q EA+K + S+ Sbjct: 197 KEADVITIHTPKTEETVNMLGAAEWKKCKKGVRVVNCARGGLYNEQDLAEAVKEGIVASV 256 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 G+DV +E + L + T H T EA + + + Sbjct: 257 GLDVVVDEP--------------NPISPLIGMPQCVVTPHLGASTFEAQDKVGLAIAEEV 302 Query: 316 SNLEKGETCPNEL 328 N+ G+ PN + Sbjct: 303 INVLGGKMVPNAV 315 >UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases n=2 Tax=Desulfovibrionaceae RepID=Q1MPI0_LAWIP Length = 323 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 101/336 (30%), Positives = 165/336 (49%), Gaps = 27/336 (8%) Query: 1 MKLAVYSTKQYDKKYLQQV--NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M++ + S K+ + E+ G +L +D E+T + A + + + D + Sbjct: 1 MQITILSGKETN-PGDNPWTPLEALG-KLTVYDLTKPEQTVERAKDAD-ILLVGRDILTT 57 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +EEL K +K I + G+N +D++ A + G+ V+ V AY +AVA+HA +++ L R Sbjct: 58 EHIEELPK--LKCIGVLGTGYNQIDIETAGKRGIPVINVTAYGVDAVAQHAFALLLELCR 115 Query: 119 RIHRAYQRTRDA-----NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 Q R+ +++ + K G+IG G IG I GF M +LA+ Sbjct: 116 HTAALDQAIRNGAWSSPDWAPWKYPQVELTYKCFGIIGYGNIGQKAGYIAHGFDMSVLAY 175 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 D P + DL +F +DV+SLHCPLT +N+HL+N+ E MK+G +I+N + Sbjct: 176 DERPVQPPSYTPFSFADLDEVFKNADVLSLHCPLTEDNFHLVNKKRIETMKDGAIIINVA 235 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RGAL+D QA +AL + K+G LG D + +E L + N +FT Sbjct: 236 RGALLDEQAVADALISGKLGGLGSDAFVDEPINLNNP-------------LLSAPNTVFT 282 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H A+ + EA +I + +NL G+ P +V Sbjct: 283 PHIAWESVEARRNIVRILAENLKAWMDGK--PQSVV 316 >UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Archaea RepID=A3MTB6_PYRCJ Length = 334 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 80/338 (23%), Positives = 148/338 (43%), Gaps = 22/338 (6%) Query: 2 KLAVYSTKQY--DKKYLQQVNESFGF-----ELEFFDFLLTEKTAKTANGCEAVC--IFV 52 K+ V S K + + + +G E+ F E+ + + V Sbjct: 5 KIVVLSPAPEALLKMWATPIAQKYGIAIDEVEVVTFFEPNYEEIGRHVADADVVVGDYTF 64 Query: 53 NDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGM 112 + E++ K V+ I G++++D++A G+ V + + +VAEH I + Sbjct: 65 RIKIDASLCEKMSK--VRLIQQPSTGYDHIDVEACARRGIPVANIGGANAISVAEHTIML 122 Query: 113 MMTLNRRIHRAYQRTRDANFSLEGLTGF--TMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 + L +R A++R + ++ L ++GKT GV+G G+IG + G ++ Sbjct: 123 ALMLLKRAVYAHRRLLEGQWTQGELMNVIGEVFGKTWGVLGMGRIGREVAVRAMALGAKV 182 Query: 171 LAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + +D + + G EY L +ESD++S+H PLTP ++ E MK +++ Sbjct: 183 IYYDVVRNEEMEKRGAEYRPFNRLLAESDILSIHVPLTPATRKMIGERELRLMKPTAVVI 242 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N SRG ++D +A +A++ I G+DV+ E + + +NV Sbjct: 243 NVSRGEIVDEEALAKAVREGWIAGAGVDVFSVEP---------PPPDHPLIQAAREGYNV 293 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + T H A T EA I +L+N+ + G N + Sbjct: 294 VVTPHIAGATNEARMRIINVSLENVFKVLAGLKPDNVV 331 >UniRef50_C5NVX3 D-lactate dehydrogenase n=2 Tax=Bacilli RepID=C5NVX3_9BACL Length = 332 Score = 331 bits (851), Expect = 2e-89, Method: Composition-based stats. Identities = 101/331 (30%), Positives = 172/331 (51%), Gaps = 4/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFG-FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MKL ++ ++ +K L+ + E++ + LT G E V + N R Sbjct: 1 MKLVFFNLREDEKSALESWRNAHPEVEIDVYTEELTSANKHLLEGKEGVVLAQNKPFERD 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V E K+ GVK A R AGF+ DL+ E G+K+ VP+Y P A+AEH + + ++R Sbjct: 61 VYEYAKEQGVKVFATRSAGFDIYDLELMSEFGIKMTNVPSYSPNAIAEHVLTSALRISRN 120 Query: 120 IHRAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 ++ + NFS G+ + T GVIGTG+IG R+ G ++L +D Y + Sbjct: 121 TNKIQRNLEKHNFSWNPGILSRELRTLTVGVIGTGRIGTQAARLFSALGSKVLGYDVYQN 180 Query: 179 AAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 AA E+ + YV+ L L + SD+I++H P E H++N+ +MK+ +++N +RG L Sbjct: 181 EAAKEV-LRYVENLDDLIAASDIITIHMPAIKEYNHMVNDEFLAKMKDNSILLNAARGML 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D++A + AL + K+ G+DVYENE ++ D++ + L +V++T H A Sbjct: 240 VDTKAVLRALDSGKLLGAGLDVYENEGKYVPKNFEGKEFDDELLQTLIDRDDVIYTPHTA 299 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T A+ ++ + L+ + T N + Sbjct: 300 FYTETAIQNLVEGGLEAAVEVITTGTSANVV 330 >UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31769 Length = 541 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 87/307 (28%), Positives = 138/307 (44%), Gaps = 17/307 (5%) Query: 24 GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVD 83 F+++ E+ + I + + ++ I G NNVD Sbjct: 27 HFDVDLGADWSDEEFRSRLPEYHGILIRSATKLTEEYI--ALGTNLRVIGRAGVGVNNVD 84 Query: 84 LDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMY 143 + AA G+ V P + AEH + ++++L R + +A++ D + G +Y Sbjct: 85 VPAATRRGIVVANAPQSNVVTAAEHTMALLLSLARNVPQAHRSLTDHRWERSKFGGVEVY 144 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA-LELGVEYVDL-PTLFSESDVI 201 KT GV+G G+IG + KGFGM+++AFDP+ A +LGVE D ++ +D I Sbjct: 145 EKTLGVVGFGRIGQLVAERAKGFGMKVVAFDPFVGAERYRDLGVEKADTSADVYKVADFI 204 Query: 202 SLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYE 261 ++H P+TPE LN AF QMK+GV IVN +RG L+D A +AL + K+ +DV+ Sbjct: 205 TIHLPVTPETQGWLNAEAFAQMKDGVRIVNCARGELVDDAALKDALDSGKVAGAALDVFP 264 Query: 262 NERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 +E + NV+ T H TAEA T + + G Sbjct: 265 SEPITDYPLFD-------------GYANVVVTPHLGASTAEAQDRAGVQTAEQVIAALTG 311 Query: 322 ETCPNEL 328 T + Sbjct: 312 GTVTTAV 318 >UniRef50_C9BJM5 D-isomer specific 2-hydroxyacid dehydrogenase n=17 Tax=Bacteria RepID=C9BJM5_ENTFC Length = 339 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 100/332 (30%), Positives = 180/332 (54%), Gaps = 6/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A Y + + + +++N + ++L ++ LLT +A +AV + N Sbjct: 1 MRIACYGVRPNEIDFFEKLN-IYHYDLSLYEELLTHDNIVSAKDHDAVLLRGNCIADETN 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L +++++G++Y+ R G N++DL AA + G+ V RVP+Y P A+AE ++ M L R Sbjct: 60 LAKMQEYGIRYVFTRTVGVNHIDLQAAADFGMTVARVPSYSPNAIAELSLTFAMMLLRNT 119 Query: 121 HRAYQRTRDANFSLEGLT-GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 RT +F ++ + T G+IGTG+IG+ + KG G +++ +D + + Sbjct: 120 AYTTIRTSFKDFRVDEQMFSREIRNCTVGIIGTGRIGLTEAVLFKGLGAKVIGYDIHQTE 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA ++ + + L L ++SD++S+H P P EN ++NE QMK G +++NT+RG L Sbjct: 180 AAKKV-LTFHSLEELLAKSDIVSIHVPHIPGENDQMINEGFLAQMKKGSILINTARGELQ 238 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFED-KSNDVIQDDVFRRLSAC-HNVLFTGHQ 296 D++A + ALK+ + DV+ NE ++FF K + I D ++L VL T H Sbjct: 239 DNEAILRALKSNHLAGFATDVFANETEVFFRSFKPWETIPDPAIQQLVEMYPRVLVTPHV 298 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EAL+++ T+ +N + + NE+ Sbjct: 299 GSNTDEALSNMISTSFENFREIIETGKTKNEV 330 >UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lactobacillus RepID=C2D1B3_LACBR Length = 327 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 80/313 (25%), Positives = 140/313 (44%), Gaps = 20/313 (6%) Query: 17 QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 ++ G ++ D T+ + + + IF+ D VL ++ +K IA Sbjct: 29 KKFLTDRGIDIIEVDGNFTDGLLEHGRDADGMIIFL-DHVGEAVLSQMP--NLKIIARHG 85 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE- 135 G++++DLDA+ + G+ V P + VAE + + L++ + +A R N++ Sbjct: 86 VGYDSIDLDASAQHGVWVTNTPNANAATVAETTLAEIFDLSKNVTKASSEMRKGNYTYAL 145 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLF 195 GF + GKT G+IG G IG + + M +L ++ S G ++VDL TL Sbjct: 146 AHRGFDLAGKTLGIIGYGHIGQQVAKKASALDMPILIYNR--SKKESPYG-KFVDLDTLL 202 Query: 196 SESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSL 255 +D+++LH P +H++ + +MK +++N RG LID+ A I ALK +I Sbjct: 203 KTADIVTLHLASNPATHHIIGKDQLAEMKRSSVLINLGRGGLIDTSALINALKTHQIAGA 262 Query: 256 GMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 +DV+E E D L NVL T H T E+ + ++ + Sbjct: 263 ALDVFEEEPLPLDSD-------------LFQFDNVLLTPHIGSSTVESFSRMAVDAASEV 309 Query: 316 SNLEKGETCPNEL 328 + GE + Sbjct: 310 VRVLNGEKPQWPV 322 >UniRef50_A5VJC4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Lactobacillus reuteri RepID=A5VJC4_LACRD Length = 330 Score = 331 bits (849), Expect = 3e-89, Method: Composition-based stats. Identities = 101/326 (30%), Positives = 168/326 (51%), Gaps = 2/326 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFG-FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ +Y Q + Y+++ E ++ LL E T + G + V +F S Sbjct: 1 MKIYMYGVYQDEVPYIKEWQEEHPEVTVDSTTKLLDESTVNLSKGSDGVVVFQQKPYSDE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 L +L +G+ ++LR G +N++ + +ELG ++ VP Y P A+AE ++ + L RR Sbjct: 61 ALRQLALNGITKMSLRNVGVDNLNHELVQELGFQITNVPVYSPAAIAEFSVTQALNLLRR 120 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 Y + +++ M + G++GTG IG +I GFG +++A+ + + Sbjct: 121 TKEFYLKLAKGDYNWAPHIAKEMNKQVVGIVGTGNIGSTAAKIFAGFGAKVIAYSRHQNK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LE VEYV L L+ + +ISL+ P P +LNE F M++GV++VNT+RG L+D Sbjct: 181 E-LEGIVEYVSLDELYKRATIISLYLPHVPATDKMLNEKTFAMMQDGVLLVNTARGPLVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A IEAL + K+G +DV E +F + + D F+ L NVL T H AF Sbjct: 240 EKALIEALNSGKVGGAALDVMTGETKIFNRQINFQEVDYDEFKDLVDRPNVLITPHIAFY 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCP 325 T +A+ ++ + +L +L K T Sbjct: 300 TDQAIKNMVKMSLSANLDLIKTGTSD 325 >UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0W672_UNCMA Length = 319 Score = 331 bits (849), Expect = 3e-89, Method: Composition-based stats. Identities = 95/327 (29%), Positives = 149/327 (45%), Gaps = 20/327 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + + Y + ++ L E+ + + +R Sbjct: 4 IVIADAVSKHELYEHHFGKIGDLKVYRGPPLSMEEYLCRIAEADVAVVSHFKLPAR---- 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K +AL G+++VDLDAA G+ V P Y EAVAEH M+++ RRI Sbjct: 60 SFDSSTLKLVALTRTGYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISE 119 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A R+ F G + GKT G+IGTG+IG+ + I + FGM ++A+D + A Sbjct: 120 ADFWIREEKFDCTAFEGRELRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAVA 179 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E + YV L L +ESD I++H PLT + L++E +F MK G +I+NT+RG ++D A Sbjct: 180 EK-LRYVGLDRLCAESDFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVDQAA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + AL +I +DV++ E L A N L T H A+ T E Sbjct: 239 LLRALDEGRIAGACLDVFDQEPL-------------PPDSPLLAMSNTLLTPHIAYNTRE 285 Query: 303 ALTSISQTTLQNLSNLEKGETCPNELV 329 A +N++ G+ P +V Sbjct: 286 AKEQSIAIAAENVALYLSGK--PRNIV 310 >UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=D1U9G1_9DELT Length = 343 Score = 331 bits (849), Expect = 3e-89, Method: Composition-based stats. Identities = 87/334 (26%), Positives = 143/334 (42%), Gaps = 23/334 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRPV 60 K ++ T++ + + E + D L+ + + C+ V + + Sbjct: 3 KPKIFITRRIPDAGIDMLAEVAEVVVNPEDRTLSRAELLASVADCQGVIGLLTEKIDAEF 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + K +K A G++N+D+ A + V P +A AE A ++ RR+ Sbjct: 63 FDAAPK--LKGYANYAVGYDNIDVAEATRRSIPVSNTPGVLTDATAECAWALIFATARRV 120 Query: 121 HRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD--- 174 A + R + G G + GKT G++G G+IG AM + +GF MR+L Sbjct: 121 AEADRVMRSGAWQGWGPLQFIGQGVRGKTLGIVGAGRIGTAMALMSRGFDMRVLYTSSSG 180 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + L V TL +E+D IS+H PLTP+ HL + AAF +MK IVNT+R Sbjct: 181 RRNAVLEDTLKARLVPFDTLLAEADFISIHTPLTPDTRHLFDAAAFGRMKRTACIVNTAR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +I ++ALKN I G+DV+E E + L+ N + Sbjct: 241 GPVIKEDDLVDALKNGVIAGAGLDVFEREPAMAPG--------------LAGLDNAVVLP 286 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E+ T ++ +N+ + G+ L Sbjct: 287 HIGSATVESRTDMATLAARNMLAMLAGQRPETCL 320 >UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacillales RepID=TKRA_BACSU Length = 325 Score = 330 bits (848), Expect = 4e-89, Method: Composition-based stats. Identities = 92/332 (27%), Positives = 151/332 (45%), Gaps = 22/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVND--DGSRP 59 K V+ TK ++ + E +E+ D L ++ + E + +R Sbjct: 3 KPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLKEAEGLLTSGTSGPSINRE 62 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE K +K ++ + G++N D++A KE G+ P + VA+ A ++++ RR Sbjct: 63 LLEHAPK--LKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTLDDTVADLAFSLILSSARR 120 Query: 120 IHRAYQRTRDANF---SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDP 175 + + R + E L G ++ +T G+IG G+IG R K GF M +L + Sbjct: 121 VAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIGEQAARRAKFGFDMEVLYHNR 180 Query: 176 YPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + + +GV+Y +L TL +SD I L PLT E YH++ E F+ MKN + VN SR Sbjct: 181 HRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETYHMIGEREFKLMKNSAIFVNISR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +D +A I AL+ I G+DVYE E L NV Sbjct: 241 GKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP-------------LLQLDNVTLLP 287 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 H TA+ ++ + +N+ +G+T N Sbjct: 288 HIGSATAKVRFNMCKQAAENMLAAIQGQTPKN 319 >UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KPU0_CLOPH Length = 316 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 80/327 (24%), Positives = 141/327 (43%), Gaps = 19/327 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + D+ + + G+EL E C + + ++ V Sbjct: 1 MKQIILIPQDVDESG-KNYLQEKGYELRILQDSSIENICNNIGDCSGLLLR-TVPCTKEV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +K I G++N+D+ A G+KV P + +VAEH I +++ + I Sbjct: 59 FDAAPH--LKVIGRHGVGYDNIDIAEATAQGIKVCYTPLANANSVAEHTIMLLLACAKNI 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 A + R N+ + G ++GKT G+IG G+IG ++ + G GM++LA+ Sbjct: 117 VIADKELRQGNYEIRNQMPGIDVFGKTLGIIGFGRIGKSVAKKAALGLGMKILAYGRGLE 176 Query: 179 AAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + V + ++ L +SD ISLH P + E ++ MK +++NT+RG + Sbjct: 177 IKEVPDYVTIIKEVDELIRQSDFISLHMPYSKEMQGFMDSTKLSLMKPEAVLINTARGGI 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ++ AL N KI G+DV+ +E + L NV+ T H A Sbjct: 237 VNEDDLYHALINHKIAGAGLDVFIDEPFK------------ETLSNLFQLDNVVVTPHSA 284 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETC 324 LT EA+ +S + + G+ Sbjct: 285 ALTKEAMARMSLDAAIGIDEVLSGKKP 311 >UniRef50_C1P7N1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Bacillus coagulans 36D1 RepID=C1P7N1_BACCO Length = 329 Score = 330 bits (846), Expect = 6e-89, Method: Composition-based stats. Identities = 111/327 (33%), Positives = 179/327 (54%), Gaps = 2/327 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ Y T+ + Q+ F ++++ D +LT +TA A G EAV I N Sbjct: 3 KVVAYETRADEFPLFQKFARKFDLDIKYVDDVLTPETAMKAMGAEAVTILGNYPVGAETF 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 L+ GVKYI LR AG+N++D +AAK G++ V AY P VA+ A +++ R+ Sbjct: 63 MALRDAGVKYIGLRTAGYNHIDQEAAKAYGIRFSNV-AYSPYCVADFATMLILMCVRKAK 121 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 + R +FS+EG+ G M+ T G+IG G+IG + + L GFG ++A D Sbjct: 122 QILSRVETQDFSVEGIQGREMHNLTIGIIGAGRIGSIVAKNLSGFGCNIIAHDTVERDEL 181 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 + ++YV L L ESDVI++H PL YH++N+ +MK+GV I+N SRGA++D+ Sbjct: 182 RGI-LKYVSLDELLKESDVITIHTPLFDRTYHMINQDRIAKMKDGVCIINCSRGAVVDTD 240 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A I ++ K+G+ G+DV E+E +F D+ D++ L + NV+ T H AF T Sbjct: 241 ALIAGIEAGKVGAAGIDVLEDEEGIFHYDRRTDILAHHQLAILRSFPNVIVTPHTAFYTD 300 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 +A++ + + L +L + + E+ Sbjct: 301 QAVSDMVEMALTSLVSFMETGKSRWEI 327 >UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC4ADC Length = 319 Score = 330 bits (846), Expect = 6e-89, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 153/326 (46%), Gaps = 19/326 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V + K+ ++ + +S+GFE++ E K C+A+ + + V Sbjct: 1 MSHKVLIPQAVAKEGVE-LLKSYGFEIKHGSGASEEDLIKDVADCDAILLR-TAPCTEAV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ K +K +A AG+NNVDL+AA +LG+ P VAE +G ++ +++RI Sbjct: 59 LKAGK--NLKIVARHGAGYNNVDLEAAAKLGIWATNAPDSTTNTVAEFVLGAILAVSKRI 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAML-RILKGFGMRLLAFDPYPS 178 ++ ++ +F G + GK GV+G G+IG + + G GM +LA+DP+ + Sbjct: 117 FLMNKKIKEGDFFFKNNHKGMDLTGKKLGVVGFGRIGRKVAYKAFYGLGMEILAYDPFLT 176 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 V D T+F ESD+ISLH PL EN + + F MK +N +RG ++ Sbjct: 177 KENCPDYVTICDWETIFKESDIISLHMPLIKENIGCVGKKEFTNMKKSAHFINCARGEVV 236 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 + + IEALK ++I +DV+E E L L + NV+ T H A Sbjct: 237 NEKELIEALKTEEIAGAFLDVFEQEPPLEDNP-------------LLSMDNVIVTPHMAS 283 Query: 299 LTAEALTSISQTTLQNLSNLEKGETC 324 T E + ++ + + E Sbjct: 284 NTEECMILMAVQAASEIVKVLSNEKP 309 >UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NG91_EUBSP Length = 319 Score = 329 bits (845), Expect = 7e-89, Method: Composition-based stats. Identities = 91/315 (28%), Positives = 150/315 (47%), Gaps = 23/315 (7%) Query: 18 QVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIAL 74 ++ E ++ E+ + +AV + D+ S+ +++ K +K I+ Sbjct: 22 RLLEEHDCDVVRLVAGVATFDEQIKEEIAAADAVIAGL-DEYSKELIDLAGK--LKVISR 78 Query: 75 RCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSL 134 G++ VD++AA G+ V P + ++VA+ A+ +M+ R + + + Sbjct: 79 YGVGYDKVDVEAADRKGILVTITPGANGDSVADLAVTLMLDAARNVAAMDAAMK--GRAQ 136 Query: 135 EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPT 193 G M+ KT GVIGTG+IG + R KGF M++L +D Y + A E +YVDL T Sbjct: 137 ARPQGVEMWQKTLGVIGTGRIGQGVARRCKGFDMKILCYDIYENEAFKKECNAKYVDLST 196 Query: 194 LFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIG 253 L ESD I++H PLTPE ++ F+ MKN +IVNT+RG +I+ +A EALK+ I Sbjct: 197 LLRESDFITIHSPLTPETKDMIGAREFDMMKNDAVIVNTARGGIINEEALYEALKSGSIR 256 Query: 254 SLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQ 313 G+D +E L N + T H T EA + +S Q Sbjct: 257 GAGLDATVDEPPYD--------------SPLMTLPNCILTPHAGAATKEASSKMSLMAAQ 302 Query: 314 NLSNLEKGETCPNEL 328 N+ ++ C ++ Sbjct: 303 NVVDVLTTGDCKYKV 317 >UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HMI9_9FIRM Length = 326 Score = 329 bits (844), Expect = 1e-88, Method: Composition-based stats. Identities = 85/329 (25%), Positives = 154/329 (46%), Gaps = 21/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 +K+ + D L + + G + ++ L ++ + N + + + ++ + Sbjct: 2 IKVIYFDKVFPDMVELIESIKPSGVTVTYWYTLNDKEKEQALNSADYFLVALY-KITQEL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +++ K +K I G +N+DL AAK LG+ V P + +VAE +GM++ L R+I Sbjct: 61 IQKAPK--LKMIQKTGVGVDNIDLAAAKTLGIPVANTPGGNATSVAELTLGMIINLYRKI 118 Query: 121 HRAYQRTRDANFSLEGLTG--FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + + T+ N+ + + GKT G+IG G IG + R+ + FG ++ +D Sbjct: 119 NILDRETKKGNWMSWEFRPSSYEVKGKTHGIIGFGNIGREVARLSQAFGTNVIYYDLRRL 178 Query: 179 AAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A E L V Y +L L +SD+IS+H PLTP+ +L++E +K +++N +RG Sbjct: 179 EPAEEKRLNVTYHELNELLQKSDIISIHLPLTPDTKNLISERELALLKPTALLINVARGN 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D A ALK K+ G+DV+ E L +NVL T H Sbjct: 239 IVDEVALYRALKENKLLGAGIDVWSKEPVED--------------NPLLTLNNVLATPHI 284 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCP 325 T + L ++ +N+ +G+ Sbjct: 285 GAGTRDTLQTVLGLAFENIIATTRGKNPR 313 >UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Archaea RepID=A9A1H5_NITMS Length = 310 Score = 328 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 82/310 (26%), Positives = 145/310 (46%), Gaps = 18/310 (5%) Query: 14 KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIA 73 L ++ + G ++ + + E+ + + V + ++ +++ K K IA Sbjct: 15 PILNKILQDNGLKISYEPEITPEQILEKISDYNIVIVRSRTTITKEMID--KADNCKIIA 72 Query: 74 LRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS 133 G +NVD +AAK ++V+ AVAE +G+M++L R+ R + R+ + Sbjct: 73 RVGVGLDNVDQEAAKAKNIRVINAVEGAMNAVAELVLGLMLSLARQTARGDRGIRNEQWL 132 Query: 134 LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD--PYPSAAALELGVEYVDL 191 + L G + GK G++G G IG + R+ + M ++ +D P + E+G+ DL Sbjct: 133 KKELKGTELAGKYLGIVGLGNIGKRLGRLARALNMNIIGYDVVPIDEEFSKEVGLMKADL 192 Query: 192 PTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQK 251 TL +D +S+H PL YHLL+ MK I+NTSRG ++D A +ALKN Sbjct: 193 NTLLQSADYVSIHVPLLDSTYHLLDAQKMSTMKKTAKIINTSRGGVVDEDALYDALKNGT 252 Query: 252 IGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTT 311 +G +DV+E E + +L+ NV+ T H T EA + + Sbjct: 253 LGGAALDVFEKEPAIGT--------------KLAELDNVILTPHIGAQTKEAQSLAANVI 298 Query: 312 LQNLSNLEKG 321 + + + +G Sbjct: 299 AEKIVQILRG 308 >UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VVP3_9FIRM Length = 315 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 81/321 (25%), Positives = 138/321 (42%), Gaps = 10/321 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + + + + G E + ++ K + + + V+ + + Sbjct: 1 MKALIIDQMSEE---IDKGLKERGIEFKKVMLPKKDELIKLIPDVDVLIMRVDPFIDKDI 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ K +K I + G N++DL+ K+ + V+ P + AVAE + L R Sbjct: 58 LDAAK--NLKLILVGSVGTNHIDLEECKKRNIPVMNSPGQNSNAVAELVFSKALDLYRNT 115 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + ++ G + KT G++G G IG + I F M +LA+DPY Sbjct: 116 VQANNEVKSGIWNKYRWIGRELRNKTMGILGYGSIGRRVAEIAHVFKMDVLAYDPYFDPK 175 Query: 181 ALELG-VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V+ V L SDVI+LH PLT E ++++ E M++G +++N +RG +ID Sbjct: 176 NNPYDYVKLVSLDEALKNSDVITLHLPLTKETKNMISSKQMEGMRDGTILINAARGGVID 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A E +KN K+G +D +E D + I +L V + H Sbjct: 236 EDALYEYIKNGKLGGANLDTLADELGTGGLDTQDVPIS----SKLFELDRVYMSPHIGGS 291 Query: 300 TAEALTSISQTTLQNLSNLEK 320 T +A I LQ+L K Sbjct: 292 TIDAQDDIGHLVLQHLDEFLK 312 >UniRef50_C2EUZ1 D-lactate dehydrogenase n=4 Tax=Lactobacillus RepID=C2EUZ1_9LACO Length = 339 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 103/331 (31%), Positives = 168/331 (50%), Gaps = 4/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP- 59 MKL ++ + Y ++ G E++ LT T G + + + P Sbjct: 8 MKLIMFGVDDKEVPYAKEWATKTGNEVKLVREQLTTSTIDLVEGFDGISVLQTSKIDDPA 67 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + +LK+ G+K ++ R AGF+ DL+ AK+ GLK+ V Y P A+AE + M L RR Sbjct: 68 IYTKLKQFGIKQLSTRTAGFDMFDLELAKKNGLKITNVSIYSPRAIAEMGLTHAMYLLRR 127 Query: 120 IHRA-YQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 I + DA+F + L +Y +T ++G G IG A +I K G R++A Sbjct: 128 IGEFKERMVNDADFRWSKDLVSNEIYNQTVAIVGLGHIGGATAQIYKALGARVIAVTRET 187 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 S +VDL T E+D+I+LH PLT ++ F+QMKN +++N +RG + Sbjct: 188 SVVYAPYVDAFVDLETALKEADIITLHVPLTSSTENMFAAPQFKQMKNNAILINMARGQV 247 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +++ I ALKN +I G+D +E F + S + D F+ L A NV+ T H A Sbjct: 248 VNTNDLIAALKNHEIAGAGLDTLGDETTYFSKKVSPADVPAD-FKELVAMPNVVVTPHVA 306 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F+T A+ ++ Q +L +++ + KG+ NE+ Sbjct: 307 FMTTTAVRNMVQVSLNDIAAIVKGKNIKNEI 337 >UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XIX3_DESMR Length = 329 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 94/330 (28%), Positives = 144/330 (43%), Gaps = 22/330 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V T+ + L + E + D LT ++ A + V + D + Sbjct: 8 VVVTRAIPEAGLALLRERATVWVNPEDRPLTRDELLAQAKDADGVIGLLTDRIDAGFFDA 67 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K ++ A G++N+D+ A GL V P +A AE A +++ R I + Sbjct: 68 CPK--LRGYANYAVGYDNIDVPEATRRGLPVSNTPDVLTQATAELAFALILATARHIVAS 125 Query: 124 YQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 R +S G G + GKT G+ G G+IG+A+ R+ +GF M+++ Sbjct: 126 DAVLRSGQWSGWGPLQFIGTQLAGKTLGIYGPGRIGLAVARLSRGFDMKIITCGGRKPNP 185 Query: 181 AL--ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AL E G + + +DV+S+ PLT H N AAF +MK ++VNT RG +I Sbjct: 186 ALVAEFGAASLPFEAFLAAADVVSITAPLTDTTRHAFNAAAFARMKPTALLVNTGRGPII 245 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D A + AL+ +I G+DVYE E L L+A NV+ T H Sbjct: 246 DEAALVVALREGRIAGAGLDVYEFEPRLA--------------EGLAALPNVVITPHIGS 291 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ QNL + +G T P L Sbjct: 292 ATTEAREGMAVLAAQNLIAMLEGTTPPTCL 321 >UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV70_9CLOT Length = 316 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 92/335 (27%), Positives = 137/335 (40%), Gaps = 27/335 (8%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V + + L + E G EL + E+ + A E + I S Sbjct: 1 MKIVVLDGETTNPGDLSWERLEKLG-ELTVYARTKPEELYERAKEAE-LLITNKTVLSGK 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 ++ LK +KYI GFN VD+ AA++LG+ V VP+Y AVA+ ++ L Sbjct: 59 MIRSLK--NLKYIGTLSTGFNVVDIHAARKLGIPVCNVPSYCTNAVAQMTFSLLFALTNH 116 Query: 120 IHRAYQRTRDANFS------LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + ++ + K GV G G IG + +I GM +L + Sbjct: 117 VALHNHSVHQGDWENSTDFCYWKAPLVELESKNFGVYGFGSIGRTVAKIAADLGMNVLVY 176 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + G +V LF ESDV+SLHCPLTPE L+N MK ++NTS Sbjct: 177 SRTKKD--MPSGYRWVSQEELFRESDVLSLHCPLTPETTGLVNRKTLSLMKPTAYLINTS 234 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +I Q EAL ++ MDV E L+ C + T Sbjct: 235 RGQVIREQDLAEALNGGRLAGAAMDVLCEEPPEKGNP-------------LTHCEKCVIT 281 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H ++ E+ + T N+ KG T N++ Sbjct: 282 PHISWAAKESRDRLLHTVCDNVEAFLKG-TPQNQV 315 >UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deinococci RepID=Q1J0H2_DEIGD Length = 542 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 139/307 (45%), Gaps = 17/307 (5%) Query: 24 GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVD 83 GFE+++ L E+T + G +A+ R +LE +K I G +N+D Sbjct: 34 GFEIDYEGNLPREETLRRLPGYDALITRSRTKVDRELLEAAGDR-LKVIGRGGVGVDNID 92 Query: 84 LDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMY 143 L+A G+ V+ P + + AE AI ++ R + R+ ++TR + + G + Sbjct: 93 LEACSRRGILVLNAPESNNVSAAELAIMHLLAAARGLTRSDRKTRAGEWDRK-FLGVELK 151 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYV-DLPTLFSESDVI 201 KT G++G G+IG + +G ++++A+DPY P LGVE L L + D + Sbjct: 152 DKTLGIVGLGRIGSIVADRAQGLRLKVVAYDPYVPENKFERLGVERAATLDELLTRVDFL 211 Query: 202 SLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYE 261 ++H PLT E ++ +K G ++VN +RG ++ A +EAL++ + + G+DV+ Sbjct: 212 TVHTPLTEETNGMIGARELALLKRGAIVVNAARGGIVQEAALVEALQSGHLFAAGVDVFV 271 Query: 262 NERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 E D F + N+ T H T EA + + + G Sbjct: 272 EEPP----------APDHPF---LSAPNLGITAHLGANTFEAQERVGAEIVGRVLAALHG 318 Query: 322 ETCPNEL 328 + + Sbjct: 319 DVSKGAV 325 >UniRef50_B2KDH0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KDH0_ELUMP Length = 338 Score = 327 bits (840), Expect = 2e-88, Method: Composition-based stats. Identities = 101/334 (30%), Positives = 160/334 (47%), Gaps = 17/334 (5%) Query: 1 MKLAVYSTKQY--DKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVND-DGS 57 MK+ + + DK+ L N + +E + E + +F Sbjct: 1 MKIVFFDLDEIKPDKEILDGSNVNVEV-IELSKNVFETDENDNVFDAEGISLFSTSRKIG 59 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 +L + +K+I++R GF+ +D KE ++V VP Y VAE+ IGM+ L Sbjct: 60 SDILSKFP--NLKFISVRSTGFDAIDTTYCKEKSIRVFNVPRYGETTVAEYTIGMIFALT 117 Query: 118 RRIHRAYQRTRDAN-FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R I RA +D N ++ + + T GV+G G IG +++ + GM ++A+DPY Sbjct: 118 RNIVRANNDMKDRNQLDIKSYSSRDLEAWTLGVLGAGAIGRSVINKAQCLGMNVIAYDPY 177 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 PS ++YV L L SD+ISLH P T ENYH++ E F++MK GV I+NT+RG Sbjct: 178 PSKDF--PNIKYVSLEELIKNSDIISLHVPSTKENYHMIGEENFKKMKKGVYIINTARGD 235 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFED--------KSNDVIQDDVFRRLSACH 288 LID++A AL + + +DV E E + +D ++ + +L Sbjct: 236 LIDNKALYGALLSGHVAGTALDVLEEEGLMVGDDTLGMLAQRTKEELFTYSINTKLMNLD 295 Query: 289 NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 NV+ T H AF T +A I T +N++ E Sbjct: 296 NVIVTPHIAFDTLDARKRIMTQTCKNIAGYYNAE 329 >UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3Y3_SPHTD Length = 316 Score = 327 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 90/320 (28%), Positives = 141/320 (44%), Gaps = 21/320 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + D L + ++ L ++ G + + + + V+E Sbjct: 9 ILVCDPIDDGALDLLRRHARVDVRT--SLAPDELVDIVGGYDGLVVRGTTQITSEVIEAA 66 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ IA +N+D+DAA E G+ VV P AVAE IG+++ + R I A Sbjct: 67 TA--LRGIARVGFAVDNIDIDAATERGIVVVHSPGARTYAVAEMTIGLILAVLRHIPAAD 124 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALEL 184 + + + G + G T GVIG G+IG + R+ FG + A+ P Sbjct: 125 RSVKAGRWERRAFRGRQLRGATVGVIGYGRIGREVARLAHAFGATVKAYTQTPRPLEH-- 182 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 + VD L + SD+I+LH LT L+N A EQM++GV+IVNT+ G LID A + Sbjct: 183 -AKQVDFQALLASSDIITLHATLTSATRQLINREAIEQMRDGVVIVNTASGGLIDEAALL 241 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 EAL K+ G+DV+ +E R L V+ T T EA Sbjct: 242 EALDRGKVAGAGLDVFADEPPS--------------LRALVEHPRVVTTPRIGGSTQEAD 287 Query: 305 TSISQTTLQNLSNLEKGETC 324 ++S+ LQ+L + +GE Sbjct: 288 RAVSELALQSLLAVLRGEQP 307 >UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group RepID=B6H0R3_PENCW Length = 596 Score = 327 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 81/306 (26%), Positives = 141/306 (46%), Gaps = 14/306 (4%) Query: 25 FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDL 84 ++ L ++ + +A+ + + VL K +K +A G +NVD+ Sbjct: 29 LDVHERKGLSADELLQIIPDYDALLVRSETKVTATVLRAAK--NLKVVARAGVGVDNVDV 86 Query: 85 DAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYG 144 + A +LG+ VV P+ + A AEH I +MM++ R+I + +D + G + G Sbjct: 87 EEATKLGIVVVNSPSGNIGAAAEHTIALMMSMARKIPESCASLKDGKWERSKFVGVEVKG 146 Query: 145 KTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSAAALELGVEYVDLPTLFSESDVIS 202 KT +IG GK+G+ + R+ KG GM + A DPY P+ AA LP L + +D ++ Sbjct: 147 KTLSIIGLGKVGLTVARLAKGLGMNVNALDPYASPAVAASASVALVSSLPELLASADFLT 206 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 +H PL ++ EA Q+K G ++N +RG D A + AL++ + +DV+ + Sbjct: 207 IHTPLIASTRGMIAEAELAQLKPGARVLNVARGGTFDEDALLAALESGHLSGAAIDVFTS 266 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 E D RL A + T H T EA ++S + + + +G Sbjct: 267 EPP----------APDSSAARLIAHPRAVVTPHLGASTVEAQENVSVDVCEQVLEILQGS 316 Query: 323 TCPNEL 328 + + Sbjct: 317 LPRSAV 322 >UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia magna RepID=C2HJZ3_PEPMA Length = 313 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 96/335 (28%), Positives = 156/335 (46%), Gaps = 30/335 (8%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFD---FLLTEKTAKTANGCEAVCIFVNDDGS 57 MK+ + T + ++ +++ E FE+++ D FL E+ E + +++ Sbjct: 1 MKVLI--TNRIPEEIIKKYEE--NFEVDYHDSLDFLSKEELKTRIKDVEGLVCPLSEKID 56 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA-YDPEAVAEHAIGMMMTL 116 +++ K +K IA AGF+NVD+D AKE G+ V PA ++ AE G+M+ L Sbjct: 57 SEIIDAAK--NLKIIANYGAGFDNVDIDYAKEKGIIVTNAPASASTKSTAELTFGLMIDL 114 Query: 117 NRRIHRAYQRTRDANFSLEGLT---GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 R I + D +F G T+ GKT G+IG G+IG ++R K F M ++ + Sbjct: 115 LRNITKMNSDCYDNSFEGWKPVYGLGETLEGKTLGIIGLGRIGTEVMRKAKAFDMNVIFY 174 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + G + VDL L SDVI+LH + + +HL++ AF +MK ++N S Sbjct: 175 NRSKKEVD---GAKQVDLNYLLENSDVITLHTAYSEKLHHLIDAKAFSKMKKSAYLINAS 231 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +I Q I AL + +I +DVYE E + L N+L Sbjct: 232 RGKVISEQDLINALNDGEIAGCALDVYEFEPKIS--------------EDLRNAKNILLA 277 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T A + + T N+ + GE N++ Sbjct: 278 PHLGNATKLARVQMGEFTFDNIMQFKNGEIPKNKV 312 >UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepID=C2HP35_LACAC Length = 330 Score = 326 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 88/335 (26%), Positives = 145/335 (43%), Gaps = 27/335 (8%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK---TAKTANGCEAVCIFVNDDGSR 58 K+ V D L + + + + K + V + + Sbjct: 14 KVLVLGGLIDD--ALDDLRSTCEVTVGPVGHRPNDDRQWVLKNIAKYDGVIV-AKMIFDK 70 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +++ K +K I+ GF+++D+D A+E G+ V P AE A+ M+M R Sbjct: 71 EIIDAAK--NLKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMASAR 128 Query: 119 RIHRAYQRTRDANF---SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 RI R+ F G+T+ GKT G++G G+IG + R K GM+++ + Sbjct: 129 RIRYYDHALREGVFLNVDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGMKIIYHNR 188 Query: 176 YPSAAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + LE L YVD +L SD +SLH P T E YH++++ F MK+ ++N + Sbjct: 189 HQLKPELEAELNARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKDTSFLINVA 248 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG+L+DS + ALK KI +DV+ENE + L NV+ T Sbjct: 249 RGSLVDSDDLVAALKEGKIAGAALDVFENEPY--------------PKQDLVNMDNVIMT 294 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T +A ++++ N+ K N + Sbjct: 295 PHVGSATHKARYNLTKEAANNILTFFKEGKVINSV 329 >UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=bacterium Ellin514 RepID=B9XQY4_9BACT Length = 334 Score = 326 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 91/314 (28%), Positives = 145/314 (46%), Gaps = 19/314 (6%) Query: 18 QVNESFGFELE---FFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIAL 74 + ++ G E+ +E K +AV V + S V + +K I+ Sbjct: 21 ALLKAAGCEVVNSAILGSPGSEDVLKIIKDADAVIAGV-EKYSADVFSVPETKRLKLISR 79 Query: 75 RCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSL 134 GF+ +D+ +A G+ + P E+VA++ +G+++ L RRI Y+ + Sbjct: 80 WGVGFDAIDVTSATREGILITYTPGMTDESVADYTMGLLLALVRRIIDGYETMSKGLWQP 139 Query: 135 EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTL 194 G M GKT G++G G+IG A+ R KGFG+ L+A DP+P + G ++V L Sbjct: 140 AW--GHDMNGKTLGILGYGRIGQAVARRAKGFGLELIAHDPHPPMGTDQFGTQFVSFNEL 197 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 SD +SLH LT L+ EA ++MK ++N +RG L++ QA I AL I Sbjct: 198 LERSDYLSLHATLTSSTRDLIGEAQLQKMKPSAYLINAARGPLVNEQALIRALNEGWIAG 257 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 +D + E + D FRR N+L + HQA + E+ IS T Q Sbjct: 258 AALDAFTVEP----------LPVDHPFRR---TPNLLLSPHQASSSRESGELISLATAQA 304 Query: 315 LSNLEKGETCPNEL 328 + +L G+ L Sbjct: 305 VLDLMAGKKPKMPL 318 >UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organisms RepID=C7H518_9FIRM Length = 320 Score = 326 bits (836), Expect = 9e-88, Method: Composition-based stats. Identities = 86/329 (26%), Positives = 146/329 (44%), Gaps = 25/329 (7%) Query: 1 MKLAVYSTKQYDKKYLQQ--VNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK + + ++ L V + + E+ A + + + + Sbjct: 1 MKAVILESYVMEEGDLDWSGVKALVPDTVSYVRTA-YEEIAPRIGDAD-IVLLNKCRMNE 58 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +L++ +K++ + G +N+DL+A + G+ V VP Y +VA+ +++ + + Sbjct: 59 EILQQCP--NLKWVGIIATGTDNLDLEACRRHGVAVANVPGYSTYSVAQMTFSLLLAICQ 116 Query: 119 RIHRAYQRTRDANFSLE------GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 R + + + L+ L + GKT GV G G IG RI + FGM +L Sbjct: 117 CAERYNRAVKQGCWQLDIPESIGLLPQMELCGKTYGVYGYGSIGRQSARIARAFGMEVLV 176 Query: 173 FDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 GVE+VD TL D++SLHCP TP+ L+N A +MK G +++NT Sbjct: 177 CTRTVRPEYAADGVEFVDYDTLLRRCDILSLHCPATPQTRGLVNAEALAKMKPGAILLNT 236 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RGAL+D +A AL + ++G G D + E L A + + Sbjct: 237 ARGALVDEEAVAAALHSGQLGFYGADAFVTEPL-------------PQESPLRAEPHAIL 283 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKG 321 T H A+ T EAL ++ T +NL +G Sbjct: 284 TPHIAWTTREALQNLMDITTRNLRTWLEG 312 >UniRef50_Q7UQC8 Probable 2-hydroxyacid dehydrogenase n=3 Tax=Bacteria RepID=Q7UQC8_RHOBA Length = 406 Score = 325 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 85/334 (25%), Positives = 151/334 (45%), Gaps = 20/334 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRP 59 MK +V T+Q + L+++ E E+ + E+ + G + ++D Sbjct: 86 MKHSVLVTRQIPGESLKRLREVCEVEVWPEAIPPSREELCRLVKGRHGLLTMLSDRIDGE 145 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +++ + + ++ GFNN+D+DAAK G+ V P +A A+ A+ ++ +R Sbjct: 146 LMDVAGEQ-LCVVSNYAVGFNNIDVDAAKTRGVVVGNTPDVLTDATADLAVSLLFAASRH 204 Query: 120 IHRAYQRTRDANFSLE---GLTGFTMYGKTAGVIGTGKIGVAMLRILKG-FGMRLLAFDP 175 + A + R+ + G G KT G++G G+IG A + L G +GM LL Sbjct: 205 VLPAGNQVREGEWKTWEPTGWLGVEPSDKTLGIVGMGRIGKATAKRLVGGWGMNLLYTSR 264 Query: 176 YPS-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 ELG V+L TL +ESD +S+H LT E +L++ A +MK+ ++VNT+R Sbjct: 265 SDQGDVEKELGGRRVELDTLLAESDFVSVHVALTDETRNLIDADAIGKMKSTSVLVNTAR 324 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D A ++AL + I + G+DV E L + + Sbjct: 325 GEIVDQDALVDALNRRAIFAAGLDVTTPEPL-------------PADHALVKSPHCVILP 371 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T + ++S+ + NL G+ + Sbjct: 372 HIGSATHTSRNAMSEIAVDNLIAGLAGKPLRCSV 405 >UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGN8_THET1 Length = 319 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 86/285 (30%), Positives = 136/285 (47%), Gaps = 22/285 (7%) Query: 46 EAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAV 105 +A+ I D+ + V+E + ++ IA G +N+DL+AA+ G+ V P ++V Sbjct: 56 DAI-ITGTDELTARVIEAAGR--LRTIAKHGVGLDNIDLEAARRRGIVVTATPGAIHDSV 112 Query: 106 AEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKG 165 A+ +G+++ + R+I A+ T + G + KT G+IG G+IG + Sbjct: 113 ADLTMGLIIAVARQIVPAHNSTVAGEW--RNFVGLELRDKTLGIIGLGRIGKGVCLRALP 170 Query: 166 FGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMK 224 FGMR++A+D YP A GV +V L L + SDV++LH + LL MK Sbjct: 171 FGMRVVAYDLYPDEEFARAHGVRFVGLEELLATSDVVTLHASAGNDGR-LLGRREIGLMK 229 Query: 225 NGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRL 284 G + +NTSRG L+D A EAL ++ G+DV+E E L Sbjct: 230 PGAIFINTSRGKLVDEGALCEALAVGRLAGAGLDVFEEEPPRG---------------PL 274 Query: 285 SACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 NV+ T H A T E + + + T+QN +GE +V Sbjct: 275 LELPNVVLTPHIAGQTREGMIRMGEMTVQNCLRALRGEEPLYRVV 319 >UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UQL2_RHOBA Length = 540 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 148/326 (45%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + ++ + + S G E E L E+ ++ N +A + + LE Sbjct: 4 ILVLDDIAQEGIDLLEASEGIEYEVRTKLKGEELRQSLNEFDAAILRSGVTITPESLE-- 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ + G +N+D AA G+ V+ PA + + AEH M++ ++R I A Sbjct: 62 GNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTVSTAEHTFAMLLAMSRNIAAAN 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE- 183 Q + + + G + GKT G++G G+IG + + F M ++AFDP+ + E Sbjct: 122 QSLVEGRWDRKKFMGTQVAGKTLGIVGMGRIGREVASRAQAFDMDVVAFDPFLTDDQAES 181 Query: 184 LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 L V V + + + D +++H PLTPE L+ E++K G+ I+N +RG + DS+A Sbjct: 182 LKVRRVATVDDMLPQIDYLTVHTPLTPETRGLIGMEQLEKVKPGLRIINVARGGIYDSEA 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +E LK+ K+G + +DVYENE L V+ T H T E Sbjct: 242 MVEGLKSGKLGGVALDVYENEPCTD--------------SPLFGMPGVVCTPHLGASTEE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A T ++ + L N + + + Sbjct: 288 AQTQVAVEGIHLLLNYLRTGEIRHSV 313 >UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PHF7_9FIRM Length = 319 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 99/332 (29%), Positives = 159/332 (47%), Gaps = 26/332 (7%) Query: 5 VYSTKQYDKKYLQQ---VNESFGFELEFFDFLLT----EKTAKTANGCEAVCIFVNDDGS 57 + T + + Q+ + ES G ++ D L E+ A A + I + D + Sbjct: 4 ILITASHFRTLCQKAIHLLESNGHQVILNDHELPYYSFEELAVWAPEIDGAIIGM-DQWN 62 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V + K +K +A G +N+DL+AAK G++VV + AVAE A+ M++ Sbjct: 63 EQVFQIAPK--LKILARFGVGVDNIDLEAAKRHGVQVVNAAGMNANAVAELAVAMILNCL 120 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R I ++ D +S G + GKT G++G G IG + + L GF +RLLA+DPYP Sbjct: 121 RGIPELNRKLTDGQWSRA--VGRDLLGKTVGLLGFGDIGGRVAKKLSGFEVRLLAYDPYP 178 Query: 178 S-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + A LGV DL T+ ++SD++S+H P P H++N F +MK +NT+RGA Sbjct: 179 NREKAAALGVTLTDLDTVLTQSDILSIHMPSIPATRHVMNRETFAKMKPDSYFINTARGA 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D+QA ++A+ + +DVYE E + + + H Sbjct: 239 LVDTQALVDAVAGGHLAGAAVDVYEQEPL-------------PMGAPILHTPGIQCIPHA 285 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E ++IS T Q + + G+ N L Sbjct: 286 GAETRETYSNISMMTAQAVIDSLSGKEPKNWL 317 >UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTH2_9ACTO Length = 324 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 97/323 (30%), Positives = 154/323 (47%), Gaps = 22/323 (6%) Query: 7 STKQYDKKYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 S + K+ +++ E G+E+ + L ++ K A C V + DD S PVL + Sbjct: 14 SFASAELKFARKLLEESGYEVTYNQSGKPLDADQLVKAARDCVGVLAGL-DDFSTPVLNQ 72 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 L ++ I+ G + VDL A + G+ V P + AVAE A+ M TL R + + Sbjct: 73 LPD--LRVISRYGVGVDRVDLRTAGDNGVIVTNTPGANSTAVAEMALSSMFTLARHVSQL 130 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE 183 + TR + + G + T G++G G IG A+ R++ G M++L +DP+ Sbjct: 131 NETTRRGQWLR--VVGTELSQATLGIVGYGSIGRALRRLVTGLEMKVLVYDPFFDPDTDP 188 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 V+ V+L L ES+ ISLH PLTP HL +++ F M G ++NTSRG +ID AA Sbjct: 189 T-VQGVELAELVRESNFISLHLPLTPATEHLFDDSMFRLMSPGTFLINTSRGGIIDESAA 247 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 + AL+ ++ L +D YE E L NV+ T H T ++ Sbjct: 248 VVALEAGQLAGLALDAYEQEPP-------------SPEHELFRFSNVIATPHSGAQTVQS 294 Query: 304 LTSISQTTLQNLSNLEKGETCPN 326 +++ + NL GE+ N Sbjct: 295 RIRMARGAVDNLLRALAGESVTN 317 >UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS02_ROSCS Length = 341 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 86/343 (25%), Positives = 144/343 (41%), Gaps = 32/343 (9%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDF----LLTEKTAKTANGCEAVCIFVNDDG 56 M+ VY T++ + + V + E F+D + E + + + + D Sbjct: 1 MRPRVYLTRRLPQAAVDIVTAAC--ETTFWDDEALPVPRETLLRAVAEVDGILTLLTDRV 58 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 +L+ + +K +A G++NVDL A G+ + P E A+ +++ Sbjct: 59 DVELLDAAPR--LKVVANMAVGYDNVDLPALTARGVLLTNTPDVLTETTADLVWALILAA 116 Query: 117 NRRIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 +RR+ ++ +S + G ++G T G++G G+IG A+ R GFGM +L Sbjct: 117 SRRVVEGHRLIAAGGWSTWSPMFMVGQDVHGATLGIVGAGRIGAAVARRAVGFGMPILYH 176 Query: 174 DPYPSAAALE-------LGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKN 225 + +PS A + YV L L +ESDV+ + PLTPE + F MK Sbjct: 177 NRHPSPALEAQIRATPGAAIRYVPNLDDLLTESDVVVVMVPLTPETRGMFGAREFALMKP 236 Query: 226 GVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLS 285 + VN SRG +I I+AL+ + + G+DV+E E L Sbjct: 237 TSVFVNASRGPVIREAELIDALQRGRPWAAGLDVFEREPIGAD-------------HPLL 283 Query: 286 ACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 NV+ T H T T ++ NL G+ PN + Sbjct: 284 TLPNVVLTPHIGSATVATRTRMAVVAATNLVAALTGQPVPNPV 326 >UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria RepID=DHGY_METEA Length = 314 Score = 323 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 92/337 (27%), Positives = 158/337 (46%), Gaps = 37/337 (10%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLT---EKTAKTANGCEAVCIFVNDDGSR 58 K+ D++ L F F E+ ++ T E+ + G E + + Sbjct: 4 KVVFL-----DRESLDATVREFNFPHEYKEYESTWTPEEIVERLQGAE-IAMINKVPMRA 57 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 L++L +K IA+ G + VD AAK G+ VV + Y V EH +G+M L R Sbjct: 58 DTLKQLPD--LKLIAVAATGTDVVDKAAAKAQGITVVNIRNYAFNTVPEHVVGLMFALRR 115 Query: 119 RIHRAYQRTRDANFSLE------GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 I R +++ + + G T G+IG G +G ++ + + GM++LA Sbjct: 116 AIVPYANSVRRGDWNKSKQFCYFDYPIYDIAGSTLGIIGYGALGKSIAKRAEALGMKVLA 175 Query: 173 FDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 FD +P VDL T+ ++SDVI+LH PLTP+ +++ ++MK +++NT Sbjct: 176 FDVFPQDG-------LVDLETILTQSDVITLHVPLTPDTKNMIGAEQLKKMKRSAILINT 228 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG L+D A ++ALK+ IG G DV E K +++ D + N++ Sbjct: 229 ARGGLVDEAALLQALKDGTIGGAGFDVVAQEP-----PKDGNILCD------ADLPNLIV 277 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 T H A+ + EA+ ++ + N+ G+ P +V Sbjct: 278 TPHVAWASKEAMQILADQLVDNVEAFVAGK--PQNVV 312 >UniRef50_A5IXT8 D lactate dehydrogenase n=4 Tax=Mycoplasma RepID=A5IXT8_MYCAP Length = 329 Score = 323 bits (830), Expect = 5e-87, Method: Composition-based stats. Identities = 101/332 (30%), Positives = 179/332 (53%), Gaps = 7/332 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M + + K+ + ++V E + +L +++++ +G + V + ND +R Sbjct: 1 MNVIFFGIKEVEFPIFEKVKEKYKDLKLTAVTEVISKERIHLVDGMDCVVVRENDVVNRE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE LK G+ Y+ R AGF+++DL A ELG+K+ RVP+Y P A+AE A L+RR Sbjct: 61 ILELLKAKGINYVFTRTAGFDHMDLAAGHELGIKMARVPSYSPTAIAELAFSYAHQLSRR 120 Query: 120 IHRAYQRTRDANFSLEGL-TGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + +F+++ + T ++GTGKIG ++ K FG ++L +D P+ Sbjct: 121 SLHFGYKAHKKDFTVDDFGFAKELRSSTVLIMGTGKIGYESAKMFKSFGAKVLGYDLMPN 180 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A ++ +EYV L ++D+++LH P +N L++ +MK+G ++VNTSRG + Sbjct: 181 KALTDV-IEYVSLDEGLKQADIVTLHMPYIKGQNDKLVSAELLSKMKDGAILVNTSRGQI 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC-HNVLFTGHQ 296 D +A ++A+K+ K+ +DV+ NE+ F K+ D I+D V L V+ + H Sbjct: 240 QDEKAILDAVKSGKLAGAAIDVFNNEKAYLF--KTFDKIEDPVIAELLDLWPRVIMSPHI 297 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + T EA T++ + +L NL + C N+L Sbjct: 298 GWYTQEAATNMLEISLDNLKEYVETGDCKNKL 329 >UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=10 Tax=Bacteria RepID=A1AQ02_PELPD Length = 318 Score = 323 bits (829), Expect = 5e-87, Method: Composition-based stats. Identities = 88/298 (29%), Positives = 130/298 (43%), Gaps = 20/298 (6%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 +D E+ G + + I R ++ VK I G+NN+D+ A Sbjct: 29 FTRYDNSSDEEIPSRVEG-QTIVITKELPLGRELIHCFPA-SVKLICEAGTGYNNIDIAA 86 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDAN---FSLE-GLTGFTM 142 A+ G+ V VP+Y +AVA+ AI M+ L+ + + R N F L F + Sbjct: 87 ARSRGIGVCNVPSYSTDAVAQLAITFMLNLSASLVQQQTMLRRGNLDNFQKSLQLPHFEL 146 Query: 143 YGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVIS 202 GKT GVIG G+IG ++ I + GM+++ P L+ + +V L L + SD +S Sbjct: 147 NGKTLGVIGFGEIGRRVIAIARTLGMKIIVHSRTPRPE-LDPDLRFVSLEELLATSDFVS 205 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 LHCPL H++N E MK I+NTSRG LI A +AL I G+DV E Sbjct: 206 LHCPLNDATRHVINAERLEMMKPTAFIINTSRGPLIHEPALSQALTRGTIAGAGLDVQEQ 265 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEK 320 E + L + NV+ T H + E + T N+ K Sbjct: 266 EPP-------------EPGDPLYSLENVILTPHIGWKRLETRQRLIGLTAANIDAFIK 310 >UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Pseudomonas RepID=A5W066_PSEP1 Length = 324 Score = 323 bits (828), Expect = 8e-87, Method: Composition-based stats. Identities = 88/327 (26%), Positives = 165/327 (50%), Gaps = 16/327 (4%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 +Y T + L ++++ L + + + + N +AV + S ++ Sbjct: 3 LIYVTSPIHETILSRLSDLGEVRLGYGPNAVAYEEIR--NQVDAVFLRG-GHISAEMIAA 59 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K ++ +A AG++NVD AA + G+ V P + +V EH ++++L R++ A Sbjct: 60 SPK--LRIVARHGAGYDNVDYKAAADHGVWVTNTPGANQRSVIEHVFALLLSLCRKLPLA 117 Query: 124 YQRTRDANF--SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 ++TR+ + LTG + G+T G++G G IG ++ + + FGM+++ DP ++ Sbjct: 118 SEQTRNRVWAEDRLSLTGIELEGRTLGLVGFGNIGSSVAPVAEAFGMKVIFTDPAIDPSS 177 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +VD TL S +DV+SLH PL +L+ F +MK+G M++NTSRG ++D Q Sbjct: 178 DS---RWVDFDTLLSTADVVSLHVPLLETTRNLIGVPEFAKMKDGAMLINTSRGGVVDEQ 234 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A ++ALK+ K+ G DV E + +D ++ N++ T H A T Sbjct: 235 ALVDALKSGKLAGAGADVLAAENIDMIKPFDHDTPD------IANTPNLIVTAHVAGQTD 288 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 E+L + + L+ ++ + KG+ + + Sbjct: 289 ESLLRVGMSALEAIAAVLKGQAPAHPV 315 >UniRef50_Q03UK9 Lactate dehydrogenase n=5 Tax=Leuconostocaceae RepID=Q03UK9_LEUMM Length = 329 Score = 322 bits (827), Expect = 1e-86, Method: Composition-based stats. Identities = 91/330 (27%), Positives = 158/330 (47%), Gaps = 3/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ +Y+T + Y+++ E G E+ D L E T A G +A+ + PV Sbjct: 1 MKILMYNTVSDEMPYVEKWTEKTGHEVVTIDQPLNETTVDRAKGFDAITTQQTTAINAPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +L + +K IA+R G++ +DL A +++ V AY P A+AE+ + + L R Sbjct: 61 YAQLAQFNIKQIAIRQVGYDVLDLPEAFAHNIRLSNVAAYSPRAIAEYTLTQLFNLIRHN 120 Query: 121 HRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + + +++ G ++ T VIG G+IG A+ +L G +L DP A Sbjct: 121 KKFDRAMNTGDYTWAAGGQAREIHDLTVAVIGVGRIGTALAEMLHALGATVLGVDPIYRA 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V Y L S +DVIS H PL E ++ +E F +++ G +++N +RG ++D Sbjct: 181 QNEPF-VTYTTLDDALSRADVISFHTPLNDETRYMADENFFAKIQPGTIMLNFARGEIVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +AL+++ + DV NE D + + + DV +RL N L + H AF Sbjct: 240 MVELEKALESKLLAGAAFDVTPNENDFMNQKQDITALPADV-KRLIEYDNFLLSPHIAFY 298 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T A+ ++ + L + + G NE++ Sbjct: 299 TNTAIKNMVEMALNDAVTMVNGGVTENEIL 328 >UniRef50_A8Z3G0 (R)-2-hydroxyacid dehydrogenase n=67 Tax=Bacilli RepID=A8Z3G0_STAAT Length = 342 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 92/325 (28%), Positives = 160/325 (49%), Gaps = 10/325 (3%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + S + D Y++ E E++ LT+ + G + + + S V Sbjct: 13 KIKIMSVRDEDMPYIKAWAEKHHVEVDITKEALTDDNVEGVAGYDGLSLSQQIPLSEHVY 72 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + L + G+K IA R AGF+ DL+ A + V VP+Y P ++AE A+ + + R + Sbjct: 73 KRLNELGIKQIAQRSAGFDTYDLELANKYNFIVSNVPSYSPNSIAEFAVNQAINVVRHFN 132 Query: 122 RAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRI-LKGFGMRLLAFDPYPSA 179 + + R+ +F E + ++ VIGTG+IG + I G+ ++A+DP+P+A Sbjct: 133 QIQTKVREHDFRWEPTILSKSIKDLKVAVIGTGRIGRVVADIFANGYQSDVVAYDPFPNA 192 Query: 180 AALELGVEYVD----LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 YVD + +D+++LH P T N++L N F+ K G + VN +RG Sbjct: 193 KI----ATYVDYKDTIEEAVEGADIVTLHVPATKYNHYLFNAELFKHFKKGAVFVNCARG 248 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +L+D++A ++AL N I +D YE ER LF D+ + D + L +V+ T H Sbjct: 249 SLVDTKALLDALDNGVIKGAALDTYEFERKLFPSDQRGKTLNDPLLESLIDREDVILTPH 308 Query: 296 QAFLTAEALTSISQTTLQNLSNLEK 320 AF T A+ ++ L ++ + Sbjct: 309 IAFYTEAAVKNLIVDALDATLDVLQ 333 >UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax=Clostridiales RepID=C4ZHF5_EUBR3 Length = 329 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 84/303 (27%), Positives = 143/303 (47%), Gaps = 19/303 (6%) Query: 26 ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLD 85 ++ D A+ + + +E K +K I G+++VD+ Sbjct: 22 DVYVADNQDPNNYLDEMRDAAALIVRI-AKCDANAIENSPK--LKVIGRTGVGYDSVDVK 78 Query: 86 AAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLT-GFTMYG 144 A ELG+ VV P + +VAEHA+ M+ L++ + A N+ + G F + Sbjct: 79 KATELGIPVVITPGANNRSVAEHAVAMIFALSKNLIEAQNEMCKGNWEIRGAKKAFELER 138 Query: 145 KTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE-LGVEYV-DLPTLFSESDVIS 202 KT G++G G IG +I KG GMR+ A+DP+ + +E G +Y D L +SDV+S Sbjct: 139 KTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTKEQVEGYGAKYYEDYVELLKDSDVVS 198 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 +H PLT + +++++ MK +I+N SRG +I+ +EAL N I G DV+ + Sbjct: 199 IHVPLTDQTRNMISKKELSVMKPTALIINCSRGGIINEADLVEALNNGVIAGAGTDVFCS 258 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 E + L C N++ + H A T EA+ ++Q ++ + +G+ Sbjct: 259 EPPKTDDP-------------LLNCRNLIVSPHSAAQTREAVIKMAQMCIKGCLAVVEGK 305 Query: 323 TCP 325 P Sbjct: 306 KWP 308 >UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E3F5 Length = 311 Score = 321 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 146/329 (44%), Gaps = 24/329 (7%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 + T+ Y++++ E+ E+ + + + + + I +N+ + +++ Sbjct: 3 KILVTRNIPGNYIEKI-ENMEIEVFSGNGNMRDWLLSNIGSADGILITLNEKIDKELIDH 61 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 KK +K I+ G++++D++ AK G+ V P +A A+ G+M+ R I Sbjct: 62 GKK--LKVISTYSVGYDHIDVEYAKSKGIIVTNTPEVLTDATADLIFGLMIAAARNIVSG 119 Query: 124 YQRTRDANFSLEG----LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 ++ + G ++GKT G+IG G+IG A+ R GF M+++ + + Sbjct: 120 NDLIHKNDWKAGWNPTFMLGSEIHGKTLGIIGMGRIGKAIARRASGFDMKIIYYSRHRHD 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++ + L +SD + + L + +H ++ +MK ++N +RG +++ Sbjct: 180 VD----ADFASIDELLQQSDFVIIALDLNADTFHFMDYQKISKMKKTAFLINGTRGKIVN 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + + AL + I +DV+E+E D + + NV+ T H Sbjct: 236 EKDLVRALNEKIIEGAALDVFEDEPV-------------DNTNPILSFSNVVVTPHLGSA 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E +++T + NL N+ G+ +L Sbjct: 283 TYETRDKMAETAVTNLVNVLNGKDPLYKL 311 >UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YFM2_METS5 Length = 324 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 87/335 (25%), Positives = 150/335 (44%), Gaps = 28/335 (8%) Query: 1 MKLAV-----YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDD 55 MK V ++ D++ ++++N + F + ++ A+ Sbjct: 1 MKPVVGIDSSVIVEELDQEKVRELNSLAEI-VYFNPYAPEDQIVSLLRDAIAIVDR-KAK 58 Query: 56 GSRPVLEELKKHGVKYIALRCAGFN--NVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 S ++ EL+ +K IA AG + VDL AAKE + + P + AVAE I + Sbjct: 59 ISSKIIRELR--NLKLIARTGAGVDETRVDLKAAKERDIIITYNPGGNSVAVAELTIMLA 116 Query: 114 MTLNRRIHRAYQRTRDANFS---LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 + L R++ + +S + G + GK G++G G IG + +++ ++ Sbjct: 117 IALYRKVIPLALSVKAGKWSELKPKDTMGHELEGKAWGILGFGNIGKRVAQLVTSLNCKV 176 Query: 171 LAFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMI 229 L +DPY S+ +E GV+ + L L S+SD+IS+H PLT HL+N + MK ++ Sbjct: 177 LGYDPYVSSEIMEKHGVKSLSLEELLSKSDIISIHVPLTESTRHLINSERLKTMKKTAIL 236 Query: 230 VNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHN 289 +N SRG +ID +A E+L+N +I +D E E L + N Sbjct: 237 INVSRGGIIDDKALYESLRNGEIAGAALDTPEEEPVKVDNP-------------LLSLDN 283 Query: 290 VLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 V+ T H T EA + + ++ + KG Sbjct: 284 VIITPHIGGSTFEASIKNANSAVEEVIRFLKGLPP 318 >UniRef50_B3E5B4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=21 Tax=Bacteria RepID=B3E5B4_GEOLS Length = 332 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 88/301 (29%), Positives = 142/301 (47%), Gaps = 22/301 (7%) Query: 30 FDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKE 89 +D E + A G E V + + +L++L G+++I+L G+NNVD++AA Sbjct: 34 YDRTPAELVLERAAGAE-VILTSKVKLTAAILQQLP--GLRFISLLATGYNNVDVEAAGR 90 Query: 90 LGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANF------SLEGLTGFTMY 143 LG+ V VPAY ++VA+ +++ L Q + + S + Sbjct: 91 LGITVSNVPAYSTDSVAQTTFALLLELTTHAGLHDQAVKQGEWVRSPDHSFWKRPIVELA 150 Query: 144 GKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISL 203 G T G++G G IG A+ RI FGM+++A+ P P AA V +V L LF ++DV+SL Sbjct: 151 GLTLGIVGFGAIGRAVARIGSAFGMQVVAYTPRPPAATEFPLVRFVSLDELFGQADVVSL 210 Query: 204 HCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 +CP T EN +N E+MK ++N +RG L++ AL++ I G+DV E Sbjct: 211 NCPQTTENGGFVNAVLLERMKRSAFLINVARGGLVNESDLAAALRDGVIAGAGLDVVSVE 270 Query: 264 RDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGET 323 L L N +FT H A+ + A ++ NL+ +G+ Sbjct: 271 PML-------------PENPLLQAPNCIFTPHIAWASLAARQRLTAIVAANLAGYLQGKP 317 Query: 324 C 324 Sbjct: 318 I 318 >UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Pantoea sp. At-9b RepID=C8QAG5_9ENTR Length = 317 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 94/332 (28%), Positives = 158/332 (47%), Gaps = 27/332 (8%) Query: 1 MKLAVYSTK--QYDKKYLQQVNESFGFELEFF--DFLLTEKTAKTANGCEAVCIFVNDDG 56 MK+ S +YD + + + GFEL D L+ A+ + F D Sbjct: 1 MKVICTSPSFAKYDATPITTLQQQ-GFELITLPADAPLSALEPHLADTVAMIVAF--TDV 57 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 + +L + + +K + G +N++LDA + G+ V VP + AVA+ A +++ Sbjct: 58 NEELLSKAPQ--LKIVCKHGVGVDNINLDATRARGIYVTNVPDANKHAVADFAFALILNS 115 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R++ +A TR ++ + +YGKT G++G G IG + KGF MR++AFD Y Sbjct: 116 ARQLTQAAVETRAGHWPR--IFATDVYGKTLGIVGLGNIGKQVALRAKGFNMRVIAFDFY 173 Query: 177 PSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P A E G+E+V + L + SD I+LH PLT E +L + A ++MK ++N SRG Sbjct: 174 PDEKFAAEHGIEFVSMDQLTAASDFITLHTPLTNETRNLFDAARIKRMKKSAFLINVSRG 233 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +++ Q +AL++ I DV+E E L N + T H Sbjct: 234 GVVNEQDLFQALQDNVIAGAAADVFEQEPLAE--------------HPLFTLGNFIPTSH 279 Query: 296 QAFLTAEALTSISQTTLQNLSN-LEKGETCPN 326 A T A+++I + + + +++GE N Sbjct: 280 IAGYTDGAISAIGERCVTQIVQCIQQGERPVN 311 >UniRef50_C3XA69 Dehydrogenase n=2 Tax=Oxalobacter formigenes RepID=C3XA69_OXAFO Length = 322 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 144/330 (43%), Gaps = 20/330 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + + + V E+ G + F + G A C + V Sbjct: 6 IVITDCNHINIDAEKAVFEAAGIPWKLFQCRTEDDLIANCQGAVAAC-NQRAPFTEKVFA 64 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 L + +K + G +NVDL+AA G++V VP Y VA HA+ MM+ + R+I + Sbjct: 65 ALPE--LKMVVRYGDGVDNVDLEAATRHGVQVCNVPDYGTSEVANHALAMMLAITRKICQ 122 Query: 123 AYQRTRDANFSLEGLTGFT-MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY---PS 178 A ++ R+ ++ + + T GVIG G+IG+A + + G +++ FD + Sbjct: 123 ANEQVREGRWTYREMVPIQHLSNMTIGVIGLGRIGLAFAKRVHALGCKVIGFDIFTEHLK 182 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 +E + +D++SLHC L ++ L+N F +MK G M +N +RG L+ Sbjct: 183 GDPESSFIELTSEDDVIERADLLSLHCSLNSQDAGLMNAKTFAKMKPGAMFINVTRGGLV 242 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D +A +AL + + + +DV E + L + N+L T H A+ Sbjct: 243 DEKALADALNSGHLSAAALDVTAKEPL-------------PMDSPLRSAPNILITPHMAW 289 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + +A +++ + +GE N + Sbjct: 290 YSVQAESNLKTRCAEEAVRGFRGEKPRNPV 319 >UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Thermoproteaceae RepID=A8MCX1_CALMQ Length = 317 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 90/317 (28%), Positives = 154/317 (48%), Gaps = 17/317 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 T + D++ + +++E G +++ + E+ K + + + +R V++ Sbjct: 11 ALITDKIDERLINKLSE-MGVAVDYKPGIQHEELLKIVENYDILVVRSRTKVTREVIDRG 69 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K IA G +N+D+D A + GL +V P + AE + +M+ ++R +H Sbjct: 70 AS--LKIIARAGVGLDNIDVDYALKRGLTIVNSPNAATYSAAELTLSLMLIISRNLHLHL 127 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALE 183 ++ +S G + GKT GV+G G+IG A+ K GMR+LA D S A E Sbjct: 128 IDVKNGKWSKGLYHGIELRGKTLGVVGFGRIGRAVANYAKALGMRILATDVVDISRYAEE 187 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LG V L L S SDV++LH L E YH+LN+ + +K+ +IVNTSRG +ID++A Sbjct: 188 LGASVVSLTELLSRSDVVTLHVALNKETYHMLNDDRLKLIKDNAIIVNTSRGEVIDTKAL 247 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 + L ++ +G+DV E+E ++D +L V+ T H T +A Sbjct: 248 LNHLD--RLWGVGLDVLEHEPP-----------REDWEIKLIQHPKVVVTPHIGAETIDA 294 Query: 304 LTSISQTTLQNLSNLEK 320 I + N+ + Sbjct: 295 QGRIVDELVFNIQEALE 311 >UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Verrucomicrobia RepID=B1ZP48_OPITP Length = 326 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 143/314 (45%), Gaps = 20/314 (6%) Query: 18 QVNESFGFELEFFDFLLTE-KTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 + G+E+ L E T + +D +R VLE+ + +K ++ Sbjct: 20 DLLAQTGWEVIRARGPLNEADTLALVGEVDGYIC-GDDAITRQVLEK-ARPRLKVLSKYG 77 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG 136 G + +D+ + E G+ ++ P + VAEH +++ L + TR + + Sbjct: 78 IGVDKIDVKSCTEFGIPLLFTPGVNHTTVAEHTFLLLLALEKNFLFHTDSTRSGGWKRK- 136 Query: 137 LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALELGVEYV-DLPTL 194 TG + KT G++G G+IG + K FGM + +D Y A E GV+ V L + Sbjct: 137 -TGHELLEKTIGIVGLGRIGKEVAIRAKAFGMTPIGYDVYWDDKFAAEHGVKRVNSLDEI 195 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 F+ SD +SLH LTP+ ++N AAF +MK GV+I+N +RG ++++ + ALK+ ++G Sbjct: 196 FAASDYLSLHTNLTPQTRGMINAAAFAKMKKGVLILNCARGEIVNTADMVAALKSGQVGG 255 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 G DV + E L NV+ T H T E++ + + N Sbjct: 256 YGTDVLDQEPPAAD-------------HPLLKLPNVVCTPHIGSRTYESVVRQATAAVTN 302 Query: 315 LSNLEKGETCPNEL 328 L GE ++ Sbjct: 303 LIRAMHGEKPLAQV 316 >UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V5E1_9FIRM Length = 334 Score = 321 bits (823), Expect = 3e-86, Method: Composition-based stats. Identities = 86/327 (26%), Positives = 145/327 (44%), Gaps = 18/327 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ V + + G L + +T + +R V+ Sbjct: 3 KIYVTDYEYDSLAPEEHELARAGLTLIPQQCHTEDDVIRTCADASGLL-NQYAPITRRVI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L +K IA G N VDL+AA E G+ V+ VP Y + V+ HA ++M +R++ Sbjct: 62 EALPH--LKVIARYGVGVNTVDLEAATEHGVCVLNVPDYCADEVSNHAFALLMACHRKLA 119 Query: 122 RAYQRTRDANFSLEGLTG-FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + + + + G+T G++G G+I + + FG++ +DP+ + A Sbjct: 120 PLHTQVNGGGWDYNICKPIHRLAGQTLGLLGFGRIPRLLAEKARAFGLKFAVYDPFVTPA 179 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + G + + L + SD+IS+H PLT E HLL+ F+ MK +++NTSRG LID Sbjct: 180 IVASYGGKLLTLGEVLQASDMISVHVPLTKETEHLLSHREFDMMKPSTILINTSRGPLID 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A AL KI + G+DV E E L + N++ T H A+ Sbjct: 240 EEALYAALTQGKIAAAGLDVTEQEPLAQDSP-------------LRSLPNIIITPHAAWY 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPN 326 + EA + + ++++ G PN Sbjct: 287 SEEAECELKTKAARGIADILSGHDLPN 313 >UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetobacter baumannii RepID=B2I1D3_ACIBC Length = 325 Score = 321 bits (823), Expect = 3e-86, Method: Composition-based stats. Identities = 90/326 (27%), Positives = 151/326 (46%), Gaps = 20/326 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFE-LEFFDFLLTEKTAKTANGC--EAVCIFVNDDGS 57 MK V T +S + + ++ +K K + +A+ + S Sbjct: 1 MKRKVLITGPTLTSDALLYAQSHDIQLIPTEPYMAKDKMEKLIHDEQPDAIIVR-TGKLS 59 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R ++ +K IA GF+ +D AA E + V + ++VAEHA +M + Sbjct: 60 RDMI--FASDNLKVIAKHGVGFDTIDTQAAAERKIPVTIAVGANAQSVAEHAFALMFNVA 117 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R++ QR R+ ++ G +YGKT G+IG G IG +++++ M++ +DP+ Sbjct: 118 RQVTWLDQRIREGHWDKASANGVELYGKTLGLIGLGAIGSILMKLVAPLNMKVKVYDPFL 177 Query: 178 SAAALELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 VE D L SD+ISLHCPLT EN HL + + FE+MK+ +++NT+RG Sbjct: 178 QNLPELDYVEQEHDFEKLIETSDIISLHCPLTAENKHLFSHSQFEKMKSSSILINTARGE 237 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 LID A ++ALKN KI G+D + +E L N++ T H Sbjct: 238 LIDQAALVDALKNNKIAGAGLDTFSSEPPEKDNP-------------LWELPNLVVTPHI 284 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGE 322 T ++ + L+ + ++ G+ Sbjct: 285 GANTTDSRNRVGLLALEQIMSIWNGQ 310 >UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobacteriaceae RepID=Q18DJ4_HALWD Length = 534 Score = 320 bits (822), Expect = 4e-86, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 144/329 (43%), Gaps = 18/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V T D L+++ + G +E + E T A+ + D + V Sbjct: 1 MHMQVLVTDPIDDAGLERLRAA-GHGVETAYDIGDEALLNTITDVNALVVRSGTDVNEAV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E + + G +N+D+DAA E G+ V P + A AEH + M R I Sbjct: 60 FEAASD--LIIVGRAGIGVDNIDIDAATEHGVIVANAPEGNVRAAAEHTVAMTFAGARSI 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+ R R ++ G + GKT GV+G G++G + + L+ GM L+A+DPY S Sbjct: 118 PQAHARLRTGEWAKSEYLGTEVNGKTLGVVGLGRVGQEVAKRLESLGMDLVAYDPYISED 177 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LG E V+ T ++ +++H PLT E +++ E M +G ++N +RG ++D Sbjct: 178 RAERLGAELVEFDTCLERAEFLTVHTPLTSETAGMISTTELELM-DGGYLINCARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A A+++ + +DV+ +E L + N++ T H Sbjct: 237 EDALAAAVEDGVLDGAAVDVFADEPVA-------------PDSALLSVDNIVVTPHLGAS 283 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A +++ + + G N L Sbjct: 284 TEAAQENVATSIADQIDAAFAGAPVMNAL 312 >UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=5 Tax=Thermotogaceae RepID=A9BJ57_PETMO Length = 310 Score = 320 bits (822), Expect = 4e-86, Method: Composition-based stats. Identities = 88/320 (27%), Positives = 151/320 (47%), Gaps = 19/320 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAK-TANGCEAVCIFVNDDGSRP 59 MK+ + D+ L+++ +LE L + K + + + ++ Sbjct: 1 MKIHI--NDPLDENALKKLQNELP-DLEITSEHLEKDVLKDKIKEIDVLIVRSATKVTKE 57 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE K +K +A G +N+D+D AK G+ V+ P + +VAE IGM++ + R Sbjct: 58 ILEHADK--LKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRH 115 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-- 177 I R ++ + + L GF + KT G+IG G +G + ++LKGF L +D + Sbjct: 116 ITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEIS 175 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + V V L L SD+ISLH P + YH ++E + MK+G +I+N +RG + Sbjct: 176 AEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGV 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D ++ LKN K+ +G+DV+E E + D ++ L A NV+ T H Sbjct: 236 LDENYVLKYLKNGKLLGVGLDVFEEEPP-----------KGDFYKELFALPNVVLTPHIG 284 Query: 298 FLTAEALTSISQTTLQNLSN 317 T EA + + + Sbjct: 285 ASTKEAQERVGINIVDRVVE 304 >UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n=10 Tax=Bacteria RepID=A3CQK1_STRSV Length = 318 Score = 319 bits (819), Expect = 7e-86, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 147/328 (44%), Gaps = 22/328 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V T K+ L ++ E + + + + +A + G + ++ Sbjct: 3 KKKVLVTGIVPKEGLVKLMEKYDVTYSDGEPFSRDYVLEHLPEYDAWLLMGQ-KGDKEMI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + K ++ I+L GF++VD++ AK+ G+ V P AE +++ +R+ Sbjct: 62 DAGK--NLQIISLNAVGFDHVDIEYAKQKGIVVSNSPQAVRVPTAEMTFALLLAATKRLA 119 Query: 122 RAYQRTRDANF---SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-- 176 + R N+ S G T+ G T G+ G G+IG + K FGM++L D Y Sbjct: 120 FYDKIVRTGNWIDPSERRYQGLTLEGATLGIYGMGRIGSTVAGFAKAFGMKVLYHDLYRL 179 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 P ELGV YV+ L ++DVI++H P P +H N+ F++MKN ++N +RG Sbjct: 180 PEEREKELGVSYVEFDDLVEKADVITIHAPSLPSTHHKFNKEVFKKMKNRSYLINAARGP 239 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++ + IEALK +I G+DV+E E +V L A NV+ H Sbjct: 240 IVSEEDLIEALKTGEIAGAGLDVFEFEP--------------EVSEELRALDNVIMAPHA 285 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETC 324 T E +++ N+ + +G Sbjct: 286 GTGTIEGRRTLAAEAAANILSFFEGNPV 313 >UniRef50_P63940 D-lactate dehydrogenase n=61 Tax=Bacilli RepID=LDHD_STAAM Length = 330 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 97/328 (29%), Positives = 163/328 (49%), Gaps = 2/328 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + T+ Y+K+ + E+ LL+ T + V V Sbjct: 3 KIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLENDVY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +L+ +G+K IA R AGF+ DLD AK+ + + VP+Y PE +AE+++ + + L RR Sbjct: 63 PKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFP 122 Query: 122 RAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R + +F+ + + + T +IGTG+IG A +I GFG + A+D YP+ Sbjct: 123 DIERRVQTHDFTWQAEIMSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKD 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 L + + ++D+ISLH P E+YHL ++A F+ +K G ++VN +RGA+I++ Sbjct: 183 LDFLTYK-DSVKEAIKDADIISLHVPANKESYHLFDKAMFDHVKKGAILVNAARGAVINT 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 I A+ + + +D YENE F D +N I D L +L T H AF + Sbjct: 242 PDLIAAVNDGTLLGAAIDTYENEAAYFTNDWTNKDIDDKTLLELIEHERILVTPHIAFFS 301 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA+ ++ + L ++ TC L Sbjct: 302 DEAVQNLVEGGLNAALSVINTGTCETRL 329 >UniRef50_C1BVE3 D-lactate dehydrogenase n=1 Tax=Lepeophtheirus salmonis RepID=C1BVE3_9MAXI Length = 339 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 116/334 (34%), Positives = 187/334 (55%), Gaps = 7/334 (2%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLL--TEKTAKTANGCEAVCIFVNDDGSRPV 60 + + T+ + K ++++ E GFE E + E + A G +A+ IFVN Sbjct: 5 IFIIDTRCHLNKSMKKIFEKNGFECEVAEGFSGVPEDVLRKAKGFQAIVIFVNKKLQDSD 64 Query: 61 LEELKKHGVKYIALRCAGFNNVD-LDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +E LK +G K I AGF+N+ D KE G++V RVP+Y P ++AE+AI M L + Sbjct: 65 VEILKDNGNKMILCCSAGFDNIPKHDLLKEAGIRVARVPSYSPSSIAEYAISSMFALAKN 124 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 I R+Y+ T+ A+F + GL + KT G+IGTG IG ++ + G ++L +D YP+ Sbjct: 125 IQRSYEMTKLADFRIGGLHCILLEDKTVGIIGTGLIGKKTVQKVAGMVDKVLCYDAYPAN 184 Query: 180 AALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 ++ EYVD+ TLF+ S++IS+H PL E HL+N+ E+MK V+I+NTSRG + Sbjct: 185 DWIKTVPNAEYVDMDTLFANSNIISIHVPLLKETQHLINKDTIEKMKKDVIIINTSRGEI 244 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQD-DVFRRLSACHNVLFTGHQ 296 I++ ++ LK++KI + +DV+E E+ F+D S ++ L + NV+ + H Sbjct: 245 INTPDLVDGLKSKKIMGVALDVFEGEKAFMFKDMSKVGFENYPELEDLVSMDNVIISSHV 304 Query: 297 AFLTAEALTSISQTTLQNLSNLE-KGETCPNELV 329 AF T E++ I+ T N KG+ +V Sbjct: 305 AFYTDESIRQITDKTYNNFLGFVGKGDVDEKAVV 338 >UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 Length = 320 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 80/327 (24%), Positives = 148/327 (45%), Gaps = 20/327 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + T+ +++ ++ + FG+E++ + + C+A+ + + + + V Sbjct: 1 MSYKILITESIEEEGVE-YLKKFGYEIKMPRDTSEDVLIEEVKDCDAILVRMAN-ITEKV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + KK +K I+ G NNVD+ A EL +++ P + VAE+ +G+++ L ++ Sbjct: 59 IRAGKK--LKVISRFGVGVNNVDIKTASELSIQITNAPESNKNTVAEYTMGLIIALAKKF 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 + R NF + + G + GK G++G G IG + KGFGM+++ F + Sbjct: 117 FLYDRGLRKGNFKVRDILGIDLEGKVLGIVGLGSIGKLLALKASKGFGMKVIGFKRHIDE 176 Query: 180 AALELG-VEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + L VE D L + SD +SL+ PLT ++ + MK ++NT+RG + Sbjct: 177 ESKSLDYVELTDSLDYVLENSDFVSLNVPLTKATTKIIGKRELSFMKKDAFLINTARGEV 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D+ A AL N++I DV++ E + NV+ T H A Sbjct: 237 VDNDALCNALLNKQIAGAATDVFDGEIPSKDNP-------------IFKMENVIVTPHSA 283 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETC 324 T EA+ +S + + G Sbjct: 284 AHTIEAMKRMSVHAAIGIHEVLSGNKP 310 >UniRef50_B9DL13 D-specific D-2-hydroxyacid dehydrogenase n=4 Tax=Staphylococcus RepID=B9DL13_STACT Length = 331 Score = 318 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 98/321 (30%), Positives = 169/321 (52%), Gaps = 3/321 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ ++ + Y+++Y++ + E++F LT++ A + V + N + Sbjct: 3 KIKMFDVENYEEQYIKDWVKEHQIEVDFEHGPLTKEKATQLKDYDGVSLSHNGPFDSDLY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L HG+K IA R AGF+ DL+ A+E G+ + VP+Y P ++AE+A+ + R++ Sbjct: 63 EVLASHGIKQIAQRSAGFDMYDLEKAREWGITITTVPSYSPSSIAEYAVMGTLYFARQVP 122 Query: 122 RAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 QR +F +G + T+ T VIG G+IG R+ FG +++ +DP Sbjct: 123 LIRQRVHQHDFRWKGDIMSRTVKDLTVAVIGIGRIGSISARLFHSFGCKVVGYDPIRRPE 182 Query: 181 ALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +E VEY L +E+D+++LH P E YHL +E F K + VN +RG ++D Sbjct: 183 -MEDIVEYKESLLEAITEADIVALHIPGNKETYHLFDEEVFRHFKTETIFVNAARGMVVD 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A ++AL + KI +D YENE + + D S I+DD+ L +VL + H AF Sbjct: 242 TKAFLKALNSDKIIGAVIDTYENEAEYYRRDHSGKEIKDDILLHLIERDDVLVSPHIAFF 301 Query: 300 TAEALTSISQTTLQNLSNLEK 320 T EA+ ++++ L + + Sbjct: 302 TGEAVKNLTEGGLNSTLEVLT 322 >UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=cellular organisms RepID=SERA_YEAST Length = 469 Score = 318 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 89/323 (27%), Positives = 145/323 (44%), Gaps = 12/323 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK-TAKTANGCEAVCIFVNDDGSRP 59 MK+ + + + E G+++EF+ L E+ + A+ I + Sbjct: 59 MKILLLENVN---QTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSN 115 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VL+ K + I C G N VDLD A G+ V P + +VAE I +++L R+ Sbjct: 116 VLQHAK--NLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQ 173 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + ++ + + GKT G+IG G IG + + + G+ +L +D Sbjct: 174 LGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIV--- 230 Query: 180 AALELG-VEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + LG V L L ++SD ++LH P TPE +L+ F MK+G ++N SRG + Sbjct: 231 TIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTV 290 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D + I+A+K KI +DVY +E E ND + + L + N++ T H Sbjct: 291 VDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDEL-NSWTSELVSLPNIILTPHIG 349 Query: 298 FLTAEALTSISQTTLQNLSNLEK 320 T EA +SI LS Sbjct: 350 GSTEEAQSSIGIEVATALSKYIN 372 >UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leuconostoc RepID=Q03YV3_LEUMM Length = 314 Score = 318 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 84/321 (26%), Positives = 149/321 (46%), Gaps = 21/321 (6%) Query: 10 QYDKKYL-QQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG 68 D + +++ E G E+ EK AV I +++ + Sbjct: 8 PDDIPAVGKKILEEAGLEVVVGSGRDHEKMKAEGVEASAVLI-GTQKFDADIMDAMP--N 64 Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 +K IA G++ VD+DAA + G+ VV P +VAE A+ ++ +++ +++ + Sbjct: 65 LKVIARNGVGYDAVDVDAATQRGIYVVNTPKALSGSVAETAVSELLAISKNLYQDSKAIH 124 Query: 129 DANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVE 187 D N++ + G + GKT G++G G+IG + + L GF ++++AFDP+ GVE Sbjct: 125 DDNWNYRKAHPGRDIEGKTVGILGFGRIGQQVAKKLSGFDVKVIAFDPFAKDV---PGVE 181 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 VD T+F +D + +H P PE H + F+ MKN ++N +RG+++ + AL Sbjct: 182 LVDRETIFKTADYVMVHLPALPETQHSIGADEFKLMKNDAFLINMARGSILVESDLVLAL 241 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 K+ +I +DV+E E V L A NVL T H A T E + Sbjct: 242 KSGEIAGAALDVFEEEPL-------------PVTNPLVALENVLLTPHIASNTVETKARM 288 Query: 308 SQTTLQNLSNLEKGETCPNEL 328 + ++ + G+ + + Sbjct: 289 AVDATNDIVRVLSGKNPESAV 309 >UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pyrobaculum aerophilum RepID=Q8ZXX8_PYRAE Length = 323 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 87/338 (25%), Positives = 153/338 (45%), Gaps = 25/338 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFF-------DFLLTEKTAKTANGCEAVCIFVN 53 M S + + + +++ E E+ + E A CEA+ IF+ Sbjct: 1 MPCIFVSREGFPESMYKKLEEVGRVEVYRHGGSPWSTRGVPKEVLIDAARRCEALVIFIG 60 Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 D + VL+ +K +K ++ G +++D++ AK G+ V P +AVA+ A+G++ Sbjct: 61 DVIDKEVLDAGEK--LKIVSTASVGVDHIDVEYAKRKGVVVAHTPYVLVDAVADLAVGLL 118 Query: 114 MTLNRRIHRAYQRTRDA--NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 + + R+I + R + L G + GK AG++G G IGVA+ R LK F + + Sbjct: 119 IAVTRKIALGDRLIRSGAADAVWGSLMGVNLRGKRAGIVGLGNIGVAIARRLKAFDIEVA 178 Query: 172 AFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + LG+EY++L +L S SD I L LTPE N F ++K G + Sbjct: 179 YWSRRRKPEVEFALGIEYMELDSLLSSSDFIFLTMALTPETRWFFNRERFAKVKRGAYFI 238 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RG L+D+ A IEAL+ + +DV++ E +L++ NV Sbjct: 239 NVARGGLVDTDALIEALEAGVLAGAALDVFDVEPL-------------PARHKLASMDNV 285 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + T H T E +++ +N+ + + + Sbjct: 286 VLTPHIGSATVETRRRMAELAAENVVSFFRTGRPIYAV 323 >UniRef50_B1HNB2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Firmicutes RepID=B1HNB2_LYSSC Length = 319 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 88/329 (26%), Positives = 160/329 (48%), Gaps = 22/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNE---SFGFELEFFDFLLTE--KTAKTANGCEAVCIFVNDD 55 M + + ++++ E G E +++ T+ + AK + G + + I N+ Sbjct: 1 MLVKLLEPLNVSDSIIEKLAEPIKQAGHEFVYYNKKTTDSAELAKRSEGADVIMI-ANNP 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V+++ +K I + G ++V + A+ + V Y +AVAE IG+++ Sbjct: 60 YPTEVIDQ--NANLKLINVAFTGVDHVGIGQARNQDVMVCNAAGYANQAVAELTIGLVLD 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD- 174 + RRI + + +F G + GKT G+IGTGKIG+ R+ K FG +++A D Sbjct: 118 VYRRISQGNKEIHADHFP-GAFQGSEIKGKTVGLIGTGKIGMMTARLFKAFGAKIVASDQ 176 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + A LG+EY++L L ++SD++SLH PL L+++ E MK +++N +R Sbjct: 177 SRRNPEAEALGIEYMELDELLAQSDIVSLHIPLLSSTKGLISKEKLELMKESAILINCAR 236 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D+ A +AL +I G+DV++ E + + +L NV+ T Sbjct: 237 GPIVDNDALADALNEGRIAGAGIDVFDMEPPIPGD------------YKLLQAKNVILTP 284 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGET 323 H FLT EA+ ++ N +G+ Sbjct: 285 HVGFLTNEAMELRAKIAFDNTMAFLEGKP 313 >UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevotella RepID=D1W6S1_9BACT Length = 329 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 81/301 (26%), Positives = 143/301 (47%), Gaps = 23/301 (7%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 L ++ E+ + A + V + ++ +L + +KYI + GFN++D+ A Sbjct: 38 LTVYERTKPEEVVERAKDAQIVLV-NKVSMKADIIAQLPQ--LKYIGVLATGFNHIDVKA 94 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGF------ 140 A+E G+ V +P+Y +VA+ + T+ R+ Q+TR+ +S + Sbjct: 95 AQEHGVTVCNIPSYSTYSVAQMVFASIFTITNRVEHYAQQTREGQWSKRSDFCYWDTPLL 154 Query: 141 TMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDV 200 + GKT G++G G IG+ + RI + FGM + A+ ++ L G++ L LFS SD+ Sbjct: 155 ELAGKTMGIVGLGNIGMKVARIAREFGMEVYAY-TSKNSVDLPSGIQKTTLDGLFSVSDI 213 Query: 201 ISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVY 260 +SLHCPL+ L+ +MK+G +++NT RG L++ AL++ ++ + G DV Sbjct: 214 LSLHCPLSERTRELIKADNLRKMKHGAILINTGRGPLVNEADVAAALESGQLAAYGADVM 273 Query: 261 ENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEK 320 +E L N T H A+ T EA + + L N+ + Sbjct: 274 CSEPPAADNP-------------LLKQPNAFITPHIAWATVEARSRLMNIALNNVRCFLE 320 Query: 321 G 321 G Sbjct: 321 G 321 >UniRef50_C6VZ76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6VZ76_DYAFD Length = 337 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 91/319 (28%), Positives = 151/319 (47%), Gaps = 11/319 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + + E+ ++ ++ E + + I R + Sbjct: 30 MKILI--ADSMHPSLFE-MLEAQKWDYDYHPQYKREDIKNALPAYDGLMIRSKTFLDREM 86 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE K +++IA AG + +DL+ A+EL ++V + +AVAEHA+GM++ L I Sbjct: 87 LENAK--NLRFIARAGAGLDLIDLNVARELNIEVFHAGTGNRDAVAEHALGMLLALFTNI 144 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA Q+ R+ + EG G + GKT G+IG G G A + L GFG ++LA+D Y Sbjct: 145 LRADQQVRNGIWDREGNRGVELMGKTVGLIGYGNNGSATAKRLSGFGCKVLAYDKYRDQY 204 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E + + E+D+ISLH PLT L+N+ ++N SRG ++ Sbjct: 205 GDAFAAE-SSIEEIQREADIISLHIPLTDITRQLVNDEFISAFAKPFYLLNLSRGEVVQL 263 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A AL++ KI +DV ENE+ + Q +VF L + V+ T H A T Sbjct: 264 KAVTSALESGKIKGACLDVLENEKIGKLTPE-----QQEVFDYLKSSDRVVLTPHIAGWT 318 Query: 301 AEALTSISQTTLQNLSNLE 319 E+ I++ ++ + N Sbjct: 319 HESYVRINEVLVEQIRNWL 337 >UniRef50_Q9BLF6 D-lactate dehydrogenase n=1 Tax=Octopus vulgaris RepID=Q9BLF6_OCTVU Length = 324 Score = 317 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 95/333 (28%), Positives = 161/333 (48%), Gaps = 24/333 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDF---LLTEKTAKTANG--CEAVCIFVNDD 55 M VY T++ + E G E++F+D + ++ K G + + D Sbjct: 1 MANKVYITRRIPPVGIDLFREK-GVEIDFWDSDEAIPHQELVKNVKGKGYAGLLCLLTDQ 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V E +K ++ G+ ++DL A K + + + V+E A+ + + Sbjct: 60 VDAEVFEAAG-PSLKVVSTLSVGYEHIDLKACKARNIIACNLSKISTDCVSEFAVTLALA 118 Query: 116 LNRRIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGM-RLL 171 ++RRI R+ ++ L + G + +T GV+G G+IG + R +K F + RL+ Sbjct: 119 VSRRIEEGIAAVRNGSWGLWKPMWILGSSFANRTIGVLGMGRIGYGVARRMKAFCISRLI 178 Query: 172 AFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVN 231 D S+ A ELG E+VDL TL +SDVI + C LTP ++L N+ F++MKN +++N Sbjct: 179 YHDIKESSFAQELGAEFVDLETLLKDSDVICICCNLTPATHYLFNKENFKKMKNTAILIN 238 Query: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVL 291 TSRG +I+ +ALKN +IG+ G+DV E E RL++ N + Sbjct: 239 TSRGGVINHDDLYDALKNHEIGAAGLDVTEPEPL-------------PKEHRLNSLPNCV 285 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 T H T EA ++S N+ ++ + +T Sbjct: 286 VTLHMGSNTWEARNNMSYNAALNIDSVFENQTP 318 >UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BYY9_9CLOT Length = 330 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 89/313 (28%), Positives = 148/313 (47%), Gaps = 23/313 (7%) Query: 17 QQVNESFGFELEFFDFLLT----EKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYI 72 +++ ES G EL + L ++ A+ +A + + D+ + V + +K I Sbjct: 25 RELLESRGHELMINESALPYYTFQQLAEVVGNIDAAVVGL-DEWTEEVFRMAPR--LKVI 81 Query: 73 ALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANF 132 A G +N+D D AKE G+KV+ P + AVAE +G M+ L R I Y+ R + Sbjct: 82 AKFGVGTDNIDCDTAKEYGIKVINAPGQNSNAVAELTVGFMIQLLRNILPLYEGIRQGQW 141 Query: 133 SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDL 191 G + GKT G+ G G + + + L F ++A D +P + A + V V Sbjct: 142 VR--YIGGELKGKTVGLFGFGAVAKLVAKKLSSFETEVIACDLHPDSEYAKKYNVGLVSA 199 Query: 192 PTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQK 251 + SD++S+H P T YHL+++A +MK G ++N +RGA++D++A EALK+ Sbjct: 200 EEVVERSDILSVHLPATSATYHLVDKAMISKMKRGACMINCARGAVVDTEALTEALKSGY 259 Query: 252 IGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTT 311 + +D +E E L C NV+ T H T EA ++S T Sbjct: 260 LAGAALDAFETEPL-------------PADSLLLTCDNVICTPHTGAETYEAYRNVSLCT 306 Query: 312 LQNLSNLEKGETC 324 Q + ++ +G Sbjct: 307 AQGILDVLEGREP 319 >UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=9 Tax=Thermococcaceae RepID=B6YUM0_THEON Length = 333 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 94/336 (27%), Positives = 159/336 (47%), Gaps = 26/336 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ V + K L+++ + EL + + E+ + + + + + R V Sbjct: 1 MRPKVLVLFKIKSKPLEELKKHADVELLLYPSV--EELKEKIGEFDGIIVSPLNPIPREV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E +K +K I+ AG+++VD+ AA E G+ V +V EAVAE A+G+M+ L RRI Sbjct: 59 IERAEK--LKVISCHSAGYDHVDVKAATERGIYVTKVSGVLSEAVAEFAVGLMIALLRRI 116 Query: 121 HRAYQRTRDANFS-----LEGLTGFT-MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 + R + G +YGKT G++G G IG A+ R +K G ++ + Sbjct: 117 VYTDRFIRAGKWESHRVIWSGFKDIETVYGKTVGILGMGAIGKAIARRVKALGTEVVYWS 176 Query: 175 PYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 E+ +Y+ L + +D++ L P TPE YH++NE + M G +VN Sbjct: 177 RSRKKDIEEEVNAKYLSLEEVLKSADIVVLALPATPETYHIINEERLKLM-EGKYLVNIG 235 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG+L+D +A ++ALK K+ DV+E E E + + T Sbjct: 236 RGSLVDEEALVKALKEGKLKGYATDVFEREPVTEHELFGMEWET-------------VLT 282 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H A L+ EA+ + ++NL + +GE P +LV Sbjct: 283 PHYAGLSREAMEDMGFRAVENLLTVLRGE-VPGDLV 317 >UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlorobiaceae RepID=Q3AQU0_CHLCH Length = 538 Score = 317 bits (813), Expect = 4e-85, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 135/321 (42%), Gaps = 19/321 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + ++ GFE+ L ++ + + V Sbjct: 13 MKVLITDSV---HPQCGRLLLQHGFEVTEKPSLSPKELHAIIADYNILIVRSATSLPAEV 69 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L K ++ I G +N+DL+AA G+ V+ P + + AEH M++ R I Sbjct: 70 L--AKATQLELIGRAGTGVDNIDLEAATRQGIVVMSTPGGNAVSAAEHTCAMLLAAARHI 127 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + N++ G + GKT +IG G++G + ++ FGMR +A+DP + Sbjct: 128 PQAMADLKQGNWNKHLYAGIELEGKTLSLIGLGRVGREVAMRMQAFGMRTIAYDPAIADE 187 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 L +E + L +DVI++H L Y+LL + K GV+IVN +RG +I+ Sbjct: 188 DAALLDIELLPLHENLLRADVITIHSALDESTYNLLGKETLSLTKPGVIIVNCARGGIIN 247 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A EAL + + + +DV+ E L V+ T H + Sbjct: 248 EVALAEALASGHVAAAALDVFTKEPIAAT-------------HPLLQFPQVIATPHISAS 294 Query: 300 TAEALTSISQTTLQNLSNLEK 320 TAE ++ + + ++ Sbjct: 295 TAEGQEKVAIQMAEQIIAWKR 315 >UniRef50_B4RIC5 D-lactate dehydrogenase n=1 Tax=Phenylobacterium zucineum HLK1 RepID=B4RIC5_PHEZH Length = 338 Score = 316 bits (812), Expect = 5e-85, Method: Composition-based stats. Identities = 108/339 (31%), Positives = 174/339 (51%), Gaps = 16/339 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ V+ ++++++ + G + L + A + + FVN D S V Sbjct: 1 MRIVVFEAEEWEREACLTL--EPGHTVACTPDALAAEAADLFADAQVISPFVNSDLSATV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L + ++ IA R G++++DLD ++ + V VP Y + VAEHA +++ L R + Sbjct: 59 LRRFPR--LELIATRSTGYDHIDLDYCRQHKVTVCNVPDYGDQTVAEHAFALLLALIRHV 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A R R ANFS +GL GF + GK GV+G G+IG ++ I +GFGM ++A+D P A Sbjct: 117 PEASARARQANFSQQGLRGFELAGKVMGVVGVGRIGRRVIAIARGFGMDVVAYDRAPDAE 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A+ LG Y L + + +DV+SLH P + L+++A F +MK G ++VNT+RG ++D Sbjct: 177 AVRTLGFRYAPLNEVLATADVLSLHVPGGAGSRSLISDAEFGRMKPGAILVNTARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFE---------DKSNDVIQDDVFRRLSACHNV 290 +QA + AL + ++ +DV ER + E + L NV Sbjct: 237 AQALVRALHSGRLAGAALDVIAQERRMRDEAEIFRERLTPSPESLQALLADHALLHMPNV 296 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 L T H A+ T EA+ I TTL N+ G P +V Sbjct: 297 LVTPHIAYNTEEAVHRIIDTTLANILAFAHG--TPQNVV 333 >UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WAJ0_FUSMR Length = 313 Score = 316 bits (812), Expect = 6e-85, Method: Composition-based stats. Identities = 95/330 (28%), Positives = 153/330 (46%), Gaps = 31/330 (9%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V + L + + +G E+E +D E + + E V I +R Sbjct: 1 MKIVVLDGYTENPGDLSWEWLKKYG-EVEIYDRTPEELVYERSKDAE-VIITNKVPFNRE 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +E L K +KYI + AG+N +D++A KE + V P Y + VA+ ++ + Sbjct: 59 RVERLPK--LKYIGITAAGYNIIDIEAVKEKNIIVTNTPNYGSKVVAQMVFAHLLEITNN 116 Query: 120 IHRAYQRTRDANFS------LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + + +D +S ++ GKT G++G G IG + +I FGM++L + Sbjct: 117 VGLHSKSVKDGEWSEKLDFCYWKKPIISLEGKTIGILGYGNIGKEVEKIALVFGMKILIY 176 Query: 174 DPYPSAAALELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 D L ++ V L + SDVISLH PLT E Y L+N+ ++MK V+++NT Sbjct: 177 DR------KNLNIDNQVTLEEILKRSDVISLHLPLTEETYRLVNKETIKKMKKDVILINT 230 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 SRG L+D +EA+K+ KI +G DV +NE L + Sbjct: 231 SRGPLVDETDLLEAIKSGKIYGVGFDVLKNEPPQKD-------------SELLKNDRINI 277 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 T H A+ EA +I + +NL N G+ Sbjct: 278 TPHIAWAAIEARQNIMKIAEENLKNYLNGK 307 >UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RN56_ACIFE Length = 319 Score = 316 bits (811), Expect = 6e-85, Method: Composition-based stats. Identities = 91/316 (28%), Positives = 146/316 (46%), Gaps = 19/316 (6%) Query: 13 KKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYI 72 K ++ G+EL + AK +AV + ++ V++ K +K I Sbjct: 11 KPVAREFLTKKGYELVSPEATDEASLAKAIADVDAVIAR-TEKYTKTVVDAGK--NLKII 67 Query: 73 ALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANF 132 A G+ N+DL A + V + +VAEHAI +M+ R+I + Q R N+ Sbjct: 68 ARYGIGYENIDLAACDAKNVTVTLARGCNTYSVAEHAISLMLACFRQIPQLNQEVRKGNW 127 Query: 133 -SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAAALELGVEYVD 190 S + + KT G IG G IG+ ++I GF MR+L +D + + VE+VD Sbjct: 128 KSRDAIETHEARYKTFGSIGIGPIGLEAVKIAHFGFQMRILVYDKFVDRSQFPDWVEFVD 187 Query: 191 -LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKN 249 L L ++DV+S H PL +H+++E A MK +++N SRGA+ D +A +ALK Sbjct: 188 TLDELMEQADVVSPHLPLNKGTFHIIDEEAISHMKPTAVLLNVSRGAIWDEKAVYKALKE 247 Query: 250 QKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQ 309 +I + G DV+E E L + N + H A LT EA+ +++ Sbjct: 248 GRIAAAGADVFETEPPT-------------PDMPLFSLPNYIGCPHTAALTEEAVDAVAM 294 Query: 310 TTLQNLSNLEKGETCP 325 Q + +L G Sbjct: 295 NCAQAIDDLLNGREPK 310 >UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria RepID=Q6F7L0_ACIAD Length = 318 Score = 316 bits (811), Expect = 7e-85, Method: Composition-based stats. Identities = 80/333 (24%), Positives = 136/333 (40%), Gaps = 27/333 (8%) Query: 1 MKLAVYSTKQYDKKYLQ--QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M A D L + F +L+ + ++ + V I + Sbjct: 1 MNAAFLDYGSLDMNDLDFSPLQACFN-DLQLYSASTPDQVIPRLKDVQ-VAITNKVVINA 58 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 L L K +K I + G NNVDL AAK G+ V Y +VA+H + +M+ L Sbjct: 59 EALTRLPK--LKLILVSATGTNNVDLRAAKAQGIVVCNCQGYGTASVAQHTLTLMLALAT 116 Query: 119 RIHRAYQRTRDANFSLE------GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 + R + + GKT G++G G++G + R+ + FGM++L Sbjct: 117 SLLRYDHAVAQGRWQQASQFCFLDYPIIELSGKTLGIVGYGELGKEVARLAQAFGMKILI 176 Query: 173 FDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 + P E + ++L L + D +SLHCPLT HL++ AF MK ++N Sbjct: 177 AN-LPQRPKHE---DRLELEALLPQVDFLSLHCPLTEHTQHLIDAHAFALMKPSAFLINC 232 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG ++ QA ++ALK +I DV E ++ N++ Sbjct: 233 ARGGIVHEQALLDALKQGRIAGAATDVLSIEPPKNGNPLLDE-----------KLPNLII 281 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 T H A+ + ++ + + +N G+T Sbjct: 282 TPHSAWGSVQSRQRMVEQLAENAKAFSIGQTIR 314 >UniRef50_C7TLC2 D-2-hydroxyacid dehydrogenase n=7 Tax=Lactobacillus RepID=C7TLC2_LACRL Length = 330 Score = 316 bits (811), Expect = 7e-85, Method: Composition-based stats. Identities = 99/328 (30%), Positives = 165/328 (50%), Gaps = 2/328 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP-V 60 K+ +YS + ++ + + +++ T A G + V I + P V Sbjct: 3 KILMYSVRPDEQPAIDDWVAANDIQVDTNTVAFNADTVDLAKGYDGVVIQQHGAIPEPLV 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++LK G+K + LR G++ V+LDAA GL V VPAY P +VAE + M L R + Sbjct: 63 YQKLKSFGMKQLTLRITGYDIVNLDAAAANGLAVTNVPAYSPRSVAELVLAHAMRLIRHL 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A R ++S GL ++ T G+IG GKIG + RI + G ++ DP Sbjct: 123 GEATAREAKDDYSWGGLEAQEVHQLTIGIIGAGKIGSTVARIFRALGSTVIVADPVTRPE 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + V YVDL TL + +D++++H PL H+L+ AAF++MK ++N +RG ++D+ Sbjct: 183 LADT-VRYVDLDTLLATADIVTVHTPLDDITTHMLDAAAFKKMKKTAYLINAARGPIVDT 241 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEAL+ +I +D E E +F D+S + + L A NV + H F T Sbjct: 242 AALIEALQRGEIAGAALDTIEGEAGIFGVDRSQSGVDNTNLETLKALPNVEISPHIGFYT 301 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++ +L ++ + G P+++ Sbjct: 302 DAAVKNMIDISLDDVKTILAGGHSPHQV 329 >UniRef50_B3SAF7 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3SAF7_TRIAD Length = 324 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 84/340 (24%), Positives = 150/340 (44%), Gaps = 37/340 (10%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFF---DFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 VY T+ + ++ + G + D + ++ GC+A+ + D + VL Sbjct: 4 VYVTRCLPEDSA-RLLQKDGINVVMRSTDDAIPRQELLDNIPGCDALICMLTDKVDKDVL 62 Query: 62 EELKKH----------GVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIG 111 + KH +K IA GF+++DLD K+ + V P +AVAE + Sbjct: 63 DAAGKHDTKLNHLTSPSLKVIATVSVGFDHIDLDECKKRNIVVSNTPRVSTDAVAELTVA 122 Query: 112 MMMTLNRRIHRAYQRTRDANFSLEGLT---GFTMYGKTAGVIGTGKIGVAMLRILKGFGM 168 +++ +RR+ ++ ++ GL G + G T G+ G G+IG+A+ L+ FG+ Sbjct: 123 LLLATSRRLMECANAVKNGDWKSWGLLWMCGTELRGSTVGIFGLGRIGIAIATRLQCFGV 182 Query: 169 RLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVM 228 + + V V++ L D I ++C LTPE L NE AF +MKN + Sbjct: 183 KQFYYTDIVE-------VPQVEIEDLLKSCDFIIINCALTPETAGLFNEKAFAKMKNNCV 235 Query: 229 IVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH 288 +VN +RG +I+ + +AL + I G+DV + E + +DD L + Sbjct: 236 LVNAARGGVINQKDLYQALVSGAIKGAGLDVTDPEP----------MAKDDP---LLTLN 282 Query: 289 NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 N + H T E T ++ + N+ + G+ + Sbjct: 283 NCVVLPHIGSNTMETRTEMASLAVNNVLAVLDGKPLLTPV 322 >UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces RepID=UPI0001B4E409 Length = 333 Score = 316 bits (810), Expect = 9e-85, Method: Composition-based stats. Identities = 86/300 (28%), Positives = 131/300 (43%), Gaps = 16/300 (5%) Query: 32 FLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELG 91 + A G + ND +L+ +K + L GF+ VD +AA E G Sbjct: 34 KPEPAELHALAAGASGILCLGNDRVDAALLDAAG-PSLKVVGLASMGFDGVDREAAAERG 92 Query: 92 LKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSL---EGLTGFTMYGKTAG 148 + V P E A+ +++ RR+ A + L + G ++G T G Sbjct: 93 VVVTHTPGVLAETTADLTFSLILMARRRLGAARDSLAAGRWDLFRMDDYLGLDIHGATLG 152 Query: 149 VIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLT 208 ++G G+IG A+ R +GFGMR+L DP+ + + VDLPTL +E+DV+SLH PLT Sbjct: 153 LVGFGQIGRAVARRAQGFGMRVLHHDPFAPDDTQDPPSKAVDLPTLLAEADVVSLHVPLT 212 Query: 209 PENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFF 268 P HL+ A MK+ +V+TSRG +ID A + A++ I S G+DVYE E Sbjct: 213 PGTRHLIGAAELAAMKSTATLVSTSRGGVIDENALLHAVREGGIHSAGLDVYEREPMGTD 272 Query: 269 EDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 L V H T ++ + N+ + +G L Sbjct: 273 ------------LSPLVGEPRVATLPHIGSATEATRAAMVDLAVDNILEVLEGRPATTPL 320 >UniRef50_D1PIB3 Glycerate dehydrogenase n=2 Tax=Clostridiales RepID=D1PIB3_9FIRM Length = 316 Score = 316 bits (810), Expect = 9e-85, Method: Composition-based stats. Identities = 97/332 (29%), Positives = 151/332 (45%), Gaps = 23/332 (6%) Query: 2 KLAVYSTKQYDKKYL---QQVNESFGFEL-EFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 K+ + + + L + E+ G EF A A +A+ I N Sbjct: 3 KIVILESLGISAEELAARKAPFEAQGHTFAEFARSTDPAVLADEAKDADAL-ILANMPLP 61 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V+E K +K+I + G +++ LDAA+ G+ V Y EAVAE +GM ++L+ Sbjct: 62 GAVIEGCDK--LKFIDVAFTGVDHIGLDAARAKGITVSNASGYSNEAVAELVLGMALSLS 119 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R + QR RD + +GL GF + GKT G++G GKIG + G +LA Sbjct: 120 RNLTAVEQRCRDGK-TKDGLVGFELAGKTVGIVGLGKIGSRTAELFHALGCPILAHSRTV 178 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A A + V V L L ++SD++ LHCPL ++N MK+ +++N +RG + Sbjct: 179 HADAPDY-VRQVSLEDLLAQSDLVVLHCPLNDSTRGMINAEKLAMMKSTALLINVARGPV 237 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 + + +AL I G+DV++ E L D L C N L T H A Sbjct: 238 VVAGDLADALDQGVIAGAGIDVFDKEPPL------------DAGEPLLHCKNCLVTPHVA 285 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 F T E++T ++ NL+ G P +V Sbjct: 286 FATRESMTLRAEIVFDNLAAWLAGH--PKNVV 315 >UniRef50_Q0ADX2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Nitrosomonas RepID=Q0ADX2_NITEC Length = 322 Score = 316 bits (810), Expect = 1e-84, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 131/301 (43%), Gaps = 23/301 (7%) Query: 29 FFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAK 88 + D E+ + G E + ++ +K I + G+NNVDL AA Sbjct: 30 YHDNTSREQVTERIKGAEIII---SNKVQLDRTAIFAADQLKLICVAATGYNNVDLAAAA 86 Query: 89 ELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTG------FTM 142 E + V V Y +VA+H + M+ R Q + + + Sbjct: 87 ERNIPVCNVRNYATSSVAQHTLMFMLNFACRFVEYRQLIKKGGWQTSTYFCPLDFGVMEL 146 Query: 143 YGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVIS 202 GKT G+IG G++G A+ I K FGM+LL Y SA+++ G + + ++D I+ Sbjct: 147 AGKTLGIIGHGELGSAVANIAKAFGMKLLIA-EYKSASSIRPG--RMAFNDVIQQADFIT 203 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 LHCPL+ + HL+ + F+ MK V ++NT+R LI+ ++AL + +I +DV + Sbjct: 204 LHCPLSADTRHLIGKWEFDLMKPSVYLINTARSGLINEDDLLQALYSGRIAGAAIDVLQA 263 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 E + + N+L T H A+ + E+ + N+ N + + Sbjct: 264 EPPVNGNPLLDYP-----------HPNLLITPHSAWASVESRQRMINLLADNIRNFLQNK 312 Query: 323 T 323 Sbjct: 313 P 313 >UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PA81_9FIRM Length = 316 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 89/311 (28%), Positives = 154/311 (49%), Gaps = 24/311 (7%) Query: 25 FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDL 84 F+++++D E+T + EAV + V E +++ G+N +DL Sbjct: 24 FKIKWYDNTPPEQTIERIGTAEAVFV-NRLRLDARVFEACPS--LRFAGTFGTGYNMIDL 80 Query: 85 DAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS------LEGLT 138 DAA+ G+ V VPAY AVA++ I +++ + H + +++ L + Sbjct: 81 DAARRAGVTVCNVPAYSTAAVAQNTISLLLNIATMTHIHSRYVSTGHWTDPTDHALVSVP 140 Query: 139 GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSES 198 F + GKT G+IG G IG A+ RI FGMR+LA+ +P +A + +V L L+++S Sbjct: 141 MFELAGKTIGLIGCGDIGSAVGRIAAAFGMRVLAYRRHPDPSAGAY-IRFVALDALYAQS 199 Query: 199 DVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMD 258 D++SLHCPLTP+ +++ AA +MK+G +++NT+RG L+ + +AL K+ G+D Sbjct: 200 DIVSLHCPLTPQTRGMIDRAAIGRMKDGAVLLNTARGGLLCERDVADALDCGKLYMAGLD 259 Query: 259 VYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNL 318 V +E L+ V+ T H +++ E + + NL Sbjct: 260 VLCDEPPA-------------PDSPLARHPRVICTPHISWMPRETRARLLRAAADNLLCF 306 Query: 319 EKGETCPNELV 329 +G N +V Sbjct: 307 LEG-NPQNVIV 316 >UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=8 Tax=Proteobacteria RepID=B2IKB7_BEII9 Length = 331 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 83/328 (25%), Positives = 152/328 (46%), Gaps = 20/328 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + + + L + + G L+ D + TE A + +A+ I V++ Sbjct: 4 ILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIR-TQPLPESVIDRA 62 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K +K+++ G++ VD++A + + V + +VAEHA+ +M+ + +R+ Sbjct: 63 QK--LKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYD 120 Query: 125 QRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE 183 TR + L + GKT +IG G+IG + + +GF M +LA+DP+ AA++ Sbjct: 121 AATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLDEAAIK 180 Query: 184 L-GVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 G DL +D +SLH P P N LL E+ MK G +++NT+RG ++D + Sbjct: 181 AAGAIPTRDLEGALRSADFVSLHMPP-PRNGALLGESELASMKPGAILINTARGGVVDEK 239 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +AL + ++ G+DV+ E L V+ T H A +T Sbjct: 240 ALAKALTDGRLAGAGLDVFTQEPP-------------PADHPLLQMDRVILTPHSAVMTR 286 Query: 302 EALTSISQTTLQNLSNLEKGETCPNELV 329 E ++ + +N+ + G P+ +V Sbjct: 287 ECAARMAVSASRNILDYFAGRLDPSLVV 314 >UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=Agrobacterium tumefaciens str. C58 RepID=Q7D366_AGRT5 Length = 317 Score = 314 bits (806), Expect = 3e-84, Method: Composition-based stats. Identities = 85/316 (26%), Positives = 148/316 (46%), Gaps = 22/316 (6%) Query: 17 QQVNESFGFELE---FFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIA 73 + + + G ++ F + ++ + +AV V D + V + +K IA Sbjct: 20 KAMLAAEGIDVVENGFGRPMTFDELSARLGDVDAVIAGV-DTWNERVFNLAPR--LKAIA 76 Query: 74 LRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS 133 G +N+D+DAA G+ V P + AVAE +G++++ RRI + R + Sbjct: 77 RFGVGVDNIDIDAAHRHGIAVTNAPGGNANAVAELTLGLILSAMRRIPYLHDALRGGAWD 136 Query: 134 LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVEYVDLP 192 G + G+ G++G G I + R L GF + ++A+D +P AA +LGV ++ Sbjct: 137 R--FVGQELIGRRVGLLGFGNIARKIARKLCGFDVEVIAYDKFPDQVAATKLGVRMCEMD 194 Query: 193 TLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKI 252 + S SD++ + P PE L++ F +MK G + +NT+RGAL+D +A +AL + + Sbjct: 195 EVLSSSDILVMMMPSLPETRRLMDAGRFARMKPGSIFINTARGALVDEKALYDALVSGHL 254 Query: 253 GSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTL 312 + +DVYE E L L ++ T H A T E TSI + T Sbjct: 255 QAAAIDVYETEPAL-------------PDNPLFTLPQIVTTPHTAAETYETYTSIGRITA 301 Query: 313 QNLSNLEKGETCPNEL 328 + + ++ N+L Sbjct: 302 EAVIDVLANRQPRNQL 317 >UniRef50_UPI0001973D95 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001973D95 Length = 322 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 94/327 (28%), Positives = 153/327 (46%), Gaps = 25/327 (7%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK 65 Y Y++ L+ + E+ L + TE+ + E + + + V+E Sbjct: 10 YPAHTYER--LKTMLENLDCTLTKVE---TEEEYQKMTDAE-IMVLRIFKARQDVIER-- 61 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 G+K I AGF++VD++AA + G+ V P + AV+E A+ +M+ + R + Sbjct: 62 NKGLKMIIRWGAGFDSVDIEAAGKNGVVVANTPGANAPAVSELAVMLMLAVGRHLIDHMD 121 Query: 126 RTRDANFSLEGLT--GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP--SAAA 181 R +S +T+ K G+IG G IG + + FG + +DP+ Sbjct: 122 SLRKGVWSKNTYINQSYTLNRKLVGIIGAGNIGRQTAKKAQAFGAEIQYYDPFRLSPERE 181 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 ELG+ YV L TL SDVISLH PLT N H++ QMK+G ++VNT+RG L+D Q Sbjct: 182 QELGLRYVPLETLLKTSDVISLHVPLTDSNRHMIGAEEISQMKDGAILVNTARGGLVDDQ 241 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A EA+++ K+ G+DV ENE + +DD L ++ T H TA Sbjct: 242 ALAEAVRSGKLAGAGLDVVENEP----------LKEDD---SLLTTPGIVVTPHVGGGTA 288 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 + I + + + G+ + + Sbjct: 289 DIGDEILPMLAKEIERVINGQMPEHAV 315 >UniRef50_D1YD83 Putative glyoxylate reductase n=3 Tax=Propionibacterium acnes RepID=D1YD83_PROAC Length = 321 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 91/320 (28%), Positives = 149/320 (46%), Gaps = 27/320 (8%) Query: 20 NESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAG 78 E G E+ D + ++ ++ +A+ ++D ++ + K +K I AG Sbjct: 17 EELPGHEVVGGDHFMDRQELSRQIATADAILTSLSDPLDAEMIGQGK--NLKVIGQCAAG 74 Query: 79 FNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDAN-FSLEG- 136 FNN+DLDAA++ G+ V P EA A+ A +++ + RR A + R + + Sbjct: 75 FNNIDLDAARQAGVVVTSTPGVLHEATADLAFTLLLEVTRRTGEAERWVRAGRAWRYDHT 134 Query: 137 -LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGV-------EY 188 + G + G T G++G G+IG AM R FGM ++ + A V Sbjct: 135 FMLGAGLQGATLGIVGLGQIGEAMARRGAAFGMNVIYNARHEKDVAAIDAVNLNTQPTRR 194 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V+L LF+ SDV+SLHCPLT E HL++ A MK +VNT+RGA +D A +EALK Sbjct: 195 VELDELFATSDVVSLHCPLTDETRHLVDADALAAMKKTAYLVNTARGACVDEAALVEALK 254 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 I +G+DV+E E + + L NV+ H ++S Sbjct: 255 TGAIAGVGLDVFEEEPTITAD--------------LLTLENVVLLPHLGSAALPTREAMS 300 Query: 309 QTTLQNLSNLEKGETCPNEL 328 + +N++ + G+ + Sbjct: 301 RLAARNIAKVLDGKPAETPV 320 >UniRef50_Q2S4U0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S4U0_SALRD Length = 321 Score = 313 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 86/300 (28%), Positives = 151/300 (50%), Gaps = 22/300 (7%) Query: 36 EKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVV 95 ++ A+G + + + D + + E + G++ ++ G +N+DL+AA+ + V Sbjct: 38 DELIALADGADVLLSVLADPITEALFEA--RPGLQMVSQYAVGVDNIDLEAAEAHDVAVT 95 Query: 96 RVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGT 152 P +A A+ A +++ R + A + RD F L G + KT G++G Sbjct: 96 HTPGVLTDATADQAWALLLAAARHVPAADRYVRDGRFERWETTHLMGMELARKTIGIVGM 155 Query: 153 GKIGVAMLRILKGFGMRLLAFDPYPSAAALELGV--EYVDLPTLFSESDVISLHCPLTPE 210 G+IG A+ R GFGM ++ + + +E V +V L L + SDV+SLHCP E Sbjct: 156 GRIGTAVARRALGFGMEVIYHNRTRANPTVERQVSARHVGLGELLTTSDVVSLHCPHNDE 215 Query: 211 NYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFED 270 ++HLL+ AAF +MK ++VNT+RG ++D A ++ALK+ +I G+DV+E+E Sbjct: 216 SHHLLDAAAFSKMKASALLVNTARGPVVDEAALVDALKSGEIAGAGLDVFEDEP------ 269 Query: 271 KSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKG-ETCPNELV 329 +V L V+ H T + ++Q + +++ L G E+ P+ LV Sbjct: 270 --------EVHPGLMEQDRVVLAPHLGSATTDTRMRMAQMCVASITALLDGAESVPHRLV 321 >UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Actinomycetales RepID=SERA_MYCLE Length = 528 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 87/305 (28%), Positives = 144/305 (47%), Gaps = 17/305 (5%) Query: 25 FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDL 84 E+ + D K +A+ + VL K +K +A G +NVD+ Sbjct: 24 VEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLAAAPK--LKIVARAGVGLDNVDV 81 Query: 85 DAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYG 144 DAA G+ VV P + + AEHA+ +++ +R+I A R + +G ++G Sbjct: 82 DAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAEADASLRAHIWKRSSFSGTEIFG 141 Query: 145 KTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYVDLPTLFSESDVISL 203 KT GV+G G+IG + + FG ++A+DPY + A A +LG+E + L + +D IS+ Sbjct: 142 KTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLLARADFISV 201 Query: 204 HCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENE 263 H P TPE L+++ A + K GV+IVN +RG L+D A +A+++ + + G+DV+ E Sbjct: 202 HLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATE 261 Query: 264 RDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGET 323 L V+ T H TAEA +++ GE Sbjct: 262 PCTD--------------SPLFELSQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEF 307 Query: 324 CPNEL 328 P+ + Sbjct: 308 VPDAV 312 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archa... 438 e-122 UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehyd... 428 e-118 UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellu... 426 e-118 UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicy... 426 e-118 UniRef50_P52643 D-lactate dehydrogenase n=152 Tax=Bacteria RepID... 422 e-116 UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms... 420 e-116 UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Arch... 420 e-116 UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cell... 417 e-115 UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms ... 413 e-114 UniRef50_P44501 2-hydroxyacid dehydrogenase homolog n=103 Tax=ce... 412 e-114 UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, N... 411 e-113 UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Lepto... 409 e-113 UniRef50_A9KHK7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 408 e-112 UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verru... 406 e-112 UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms... 406 e-112 UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actin... 405 e-111 UniRef50_Q8Z0N3 D-lactate dehydrogenase n=9 Tax=Bacteria RepID=Q... 402 e-110 UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntr... 401 e-110 UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 401 e-110 UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncul... 398 e-109 UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquif... 398 e-109 UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 396 e-109 UniRef50_Q31F74 D-isomer specific 2-hydroxyacid dehydrogenase, N... 396 e-109 UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichop... 396 e-109 UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cel... 396 e-109 UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 T... 395 e-108 UniRef50_C5K2M9 D-lactate dehydrogenase n=2 Tax=Ajellomyces derm... 395 e-108 UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cell... 395 e-108 UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Ta... 395 e-108 UniRef50_P30799 2-hydroxyacid dehydrogenase homolog n=7 Tax=Bact... 394 e-108 UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellu... 394 e-108 UniRef50_B2JFX7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 394 e-108 UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staph... 393 e-108 UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=... 393 e-108 UniRef50_Q4K893 D-lactate dehydrogenase n=15 Tax=Gammaproteobact... 393 e-108 UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 393 e-108 UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonel... 393 e-108 UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clost... 393 e-108 UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Eurya... 393 e-108 UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyan... 393 e-108 UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehal... 392 e-108 UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halot... 392 e-108 UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Baci... 391 e-107 UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Delta... 391 e-107 UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bila... 391 e-107 UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinu... 391 e-107 UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dicty... 390 e-107 UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 390 e-107 UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobac... 390 e-107 UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Prote... 390 e-107 UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 389 e-107 UniRef50_B5EQZ7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 389 e-107 UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomy... 389 e-107 UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillale... 388 e-106 UniRef50_A7FYM9 D-lactate dehydrogenase n=10 Tax=Clostridium Rep... 388 e-106 UniRef50_D2LI76 D-isomer specific 2-hydroxyacid dehydrogenase NA... 388 e-106 UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, N... 388 e-106 UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 387 e-106 UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n... 387 e-106 UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verru... 387 e-106 UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacil... 386 e-106 UniRef50_B6HIS7 Pc21g23650 protein n=11 Tax=cellular organisms R... 385 e-105 UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, N... 385 e-105 UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Ther... 385 e-105 UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (P... 385 e-105 UniRef50_B4SP29 D-isomer specific 2-hydroxyacid dehydrogenase NA... 385 e-105 UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fr... 383 e-105 UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC ... 383 e-105 UniRef50_C7QLW6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 383 e-105 UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acido... 383 e-105 UniRef50_UPI0001AEC4CE D-lactate dehydrogenase n=1 Tax=Alteromon... 382 e-105 UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planc... 381 e-104 UniRef50_Q9P7Q1 2-hydroxyacid dehydrogenase homolog 2 n=2 Tax=Sc... 381 e-104 UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Baci... 380 e-104 UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplasti... 380 e-104 UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denit... 379 e-104 UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister... 378 e-103 UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms ... 378 e-103 UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 378 e-103 UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Stap... 377 e-103 UniRef50_Q22CX9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 377 e-103 UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina R... 376 e-103 UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desu... 376 e-103 UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, N... 376 e-103 UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pl... 375 e-102 UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepI... 375 e-102 UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxy... 374 e-102 UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacilla... 374 e-102 UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID... 374 e-102 UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate ... 373 e-102 UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Egger... 373 e-102 UniRef50_C0A4H0 D-isomer specific 2-hydroxyacid dehydrogenase, N... 373 e-102 UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, N... 373 e-102 UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella pal... 373 e-102 UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 373 e-102 UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cell... 373 e-102 UniRef50_B9ZMK9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 373 e-102 UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 373 e-102 UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (cla... 372 e-102 UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacte... 372 e-101 UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NA... 372 e-101 UniRef50_B7KQC7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 371 e-101 UniRef50_C5P2R3 D-lactate dehydrogenase, putative n=5 Tax=cellul... 371 e-101 UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacil... 370 e-101 UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 370 e-101 UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacte... 370 e-101 UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria... 369 e-101 UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clost... 369 e-101 UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3... 369 e-100 UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostri... 368 e-100 UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostell... 368 e-100 UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirel... 367 e-100 UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brach... 366 e-100 UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 366 e-100 UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydro... 366 e-100 UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n... 366 e-100 UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acida... 365 1e-99 UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostri... 365 1e-99 UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Ta... 365 1e-99 UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase fa... 364 2e-99 UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, N... 364 3e-99 UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lacto... 363 5e-99 UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NA... 363 5e-99 UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group ... 363 7e-99 UniRef50_O66939 D-lactate dehydrogenase n=1 Tax=Aquifex aeolicus... 363 7e-99 UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostri... 363 7e-99 UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Fir... 362 1e-98 UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostri... 362 1e-98 UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clos... 361 2e-98 UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax... 361 2e-98 UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desul... 360 3e-98 UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 T... 360 4e-98 UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacte... 360 5e-98 UniRef50_C0GGJ9 D-isomer specific 2-hydroxyacid dehydrogenase NA... 359 8e-98 UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS... 359 9e-98 UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepI... 359 9e-98 UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, N... 359 1e-97 UniRef50_A8SQC5 Putative uncharacterized protein n=4 Tax=Clostri... 358 1e-97 UniRef50_A5VLZ7 D-isomer specific 2-hydroxyacid dehydrogenase, N... 358 2e-97 UniRef50_A8UL50 D-lactate dehydrogenase n=2 Tax=unclassified Fla... 358 2e-97 UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydro... 358 2e-97 UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales Re... 357 3e-97 UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deino... 357 4e-97 UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopire... 356 4e-97 UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma ... 356 5e-97 UniRef50_Q7UQC8 Probable 2-hydroxyacid dehydrogenase n=3 Tax=Bac... 356 6e-97 UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostri... 356 6e-97 UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0... 356 8e-97 UniRef50_A6LTK2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 356 9e-97 UniRef50_C8W7M7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 355 1e-96 UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, N... 355 1e-96 UniRef50_C1DWX6 Glyoxylate reductase (Glycolate reductase) n=6 T... 354 2e-96 UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 354 2e-96 UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniph... 354 2e-96 UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlor... 354 2e-96 UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NA... 354 2e-96 UniRef50_C9KNY1 D-lactate dehydrogenase n=2 Tax=Clostridiales Re... 354 3e-96 UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 354 3e-96 UniRef50_C3XA69 Dehydrogenase n=2 Tax=Oxalobacter formigenes Rep... 353 4e-96 UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia... 353 6e-96 UniRef50_Q89388 A53R protein n=3 Tax=Chlorovirus RepID=Q89388_PBCV1 352 8e-96 UniRef50_B1L1I5 D-lactate dehydrogenase n=16 Tax=Clostridium Rep... 351 1e-95 UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetoba... 351 2e-95 UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosin... 351 2e-95 UniRef50_Q59642 D-lactate dehydrogenase n=5 Tax=Lactobacillaceae... 351 2e-95 UniRef50_C1DZN2 D-Lactate dehydrogenase n=2 Tax=Micromonas RepID... 351 2e-95 UniRef50_O83080 D-lactate dehydrogenase n=2 Tax=Treponema pallid... 351 3e-95 UniRef50_D2QQC4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 351 3e-95 UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 350 4e-95 UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobact... 350 4e-95 UniRef50_P17584 D-2-hydroxyisocaproate dehydrogenase n=9 Tax=Lac... 350 4e-95 UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organis... 349 6e-95 UniRef50_Q54UF7 Putative D-lactate dehydrogenase n=1 Tax=Dictyos... 349 6e-95 UniRef50_B5HCN2 D-lactate dehydrogenase n=6 Tax=Streptomyces Rep... 349 9e-95 UniRef50_Q0SVM3 D-lactate dehydrogenase n=31 Tax=Bacteria RepID=... 349 9e-95 UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, N... 348 2e-94 UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 347 4e-94 UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 347 4e-94 UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n... 347 4e-94 UniRef50_B3SAF7 Putative uncharacterized protein n=1 Tax=Trichop... 346 4e-94 UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leu... 346 5e-94 UniRef50_C4Z227 D-lactate dehydrogenase n=1 Tax=Eubacterium elig... 346 7e-94 UniRef50_Q9BLF6 D-lactate dehydrogenase n=1 Tax=Octopus vulgaris... 346 8e-94 UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NA... 346 8e-94 UniRef50_A4S3N1 Predicted protein n=2 Tax=Ostreococcus RepID=A4S... 346 8e-94 UniRef50_Q8EMM3 Dehydrogenase n=5 Tax=Bacteria RepID=Q8EMM3_OCEIH 346 9e-94 UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NA... 345 1e-93 UniRef50_D1PMF0 D-lactate dehydrogenase n=1 Tax=Subdoligranulum ... 345 1e-93 UniRef50_Q6RK69 D-lactate dehydrogenase n=4 Tax=Lactobacillus Re... 345 1e-93 UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=ce... 345 2e-93 UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NA... 344 2e-93 UniRef50_C0QZF2 Lactate dehydrogenase-like dehydrogenase n=2 Tax... 344 2e-93 UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NA... 344 2e-93 UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Ge... 344 2e-93 UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax... 344 2e-93 UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, N... 344 2e-93 UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerot... 344 3e-93 UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Ta... 343 4e-93 UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campy... 343 4e-93 UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 343 4e-93 UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovib... 343 4e-93 UniRef50_C9NGL5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 343 5e-93 UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Acti... 343 8e-93 UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria R... 343 8e-93 UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, N... 342 9e-93 UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=... 342 1e-92 UniRef50_B2GCQ6 D-2-hydroxyisocaproate dehydrogenase n=3 Tax=Lac... 342 1e-92 UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, N... 342 1e-92 UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Acti... 342 1e-92 UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 342 1e-92 UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 2e-92 UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 2e-92 UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 2e-92 UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevo... 341 2e-92 UniRef50_B8FRA5 D-isomer specific 2-hydroxyacid dehydrogenase NA... 341 2e-92 UniRef50_D2W085 Predicted protein n=1 Tax=Naegleria gruberi RepI... 341 2e-92 UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=... 341 3e-92 UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii Re... 340 3e-92 UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases... 340 3e-92 UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostri... 340 4e-92 UniRef50_C8P020 D-lactate dehydrogenase n=1 Tax=Erysipelothrix r... 340 4e-92 UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, N... 340 5e-92 UniRef50_C5PUM3 Glyoxylate reductase n=2 Tax=Sphingobacterium sp... 340 5e-92 UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces... 339 5e-92 UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerot... 339 6e-92 UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurot... 339 6e-92 UniRef50_D1CE36 D-isomer specific 2-hydroxyacid dehydrogenase NA... 339 8e-92 UniRef50_Q8CPW2 Glycerate dehydrogenase n=6 Tax=Staphylococcus R... 339 8e-92 UniRef50_C0QQQ9 Glycerate dehydrogenase (NADH-dependent hydroxyp... 339 8e-92 UniRef50_C1SG57 Lactate dehydrogenase-like oxidoreductase n=1 Ta... 339 9e-92 UniRef50_B3E5B4 D-isomer specific 2-hydroxyacid dehydrogenase NA... 339 9e-92 UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NA... 339 9e-92 UniRef50_B2A705 D-isomer specific 2-hydroxyacid dehydrogenase NA... 339 9e-92 UniRef50_A1ZX42 Glycerate dehydrogenase n=1 Tax=Microscilla mari... 339 1e-91 UniRef50_A6TL35 D-isomer specific 2-hydroxyacid dehydrogenase, N... 339 1e-91 UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Acti... 338 1e-91 UniRef50_B2UXX3 D-lactate dehydrogenase n=2 Tax=Clostridium RepI... 338 2e-91 UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria ... 338 2e-91 UniRef50_A7ZTA0 Glyoxylate/hydroxypyruvate reductase B n=224 Tax... 338 2e-91 UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostri... 338 3e-91 UniRef50_Q3KHS7 2-ketogluconate reductase n=24 Tax=Proteobacteri... 337 3e-91 UniRef50_Q0ADX2 D-isomer specific 2-hydroxyacid dehydrogenase, N... 337 3e-91 UniRef50_A5VTC2 D-isomer specific 2-hydroxyacid dehydrogenases f... 337 4e-91 UniRef50_B6WY27 Putative uncharacterized protein n=1 Tax=Desulfo... 337 4e-91 UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobil... 337 4e-91 UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase fa... 336 5e-91 UniRef50_P26297 D-lactate dehydrogenase n=73 Tax=Lactobacillales... 336 5e-91 UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydroge... 336 5e-91 UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGD... 336 6e-91 UniRef50_Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase n... 336 6e-91 Sequences not found previously or not previously below threshold: >UniRef50_D2RHI0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RHI0_ARCPR Length = 525 Score = 438 bits (1129), Expect = e-122, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 161/327 (49%), Gaps = 17/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V ++ + + G E++ + E+ + +A+ + +R V++ Sbjct: 1 MKVLVADPIAEEAID-FMKKNGLEVDVKTDISHEELLEVIQDYDALIVRSRTRVTRDVID 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 KK +K I G +N+D+D A E G+ VV P + + AEH IG+++++ R+I + Sbjct: 60 RAKK--LKIIGRAGVGVDNIDVDYATEKGIVVVNAPGGNSVSAAEHTIGLILSIARKIPQ 117 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A + ++ + + G + GKT G++G G+IG + + ++ F M +LA+DPY S A Sbjct: 118 ADRSVKEGKWERKKFVGIELRGKTLGIVGLGRIGYEVAKRMRCFEMNILAYDPYVSEERA 177 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +G + V L L SD+I++H P T E +++ FE MK+GV I+N +RG ++D + Sbjct: 178 KSVGAKLVSLEELLRNSDIITIHVPKTKETEKMISYKEFEIMKDGVYIINAARGGIVDEK 237 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +AL + K+ +DVYE E D L NV+ T H T Sbjct: 238 ALYDALVSGKVAGAALDVYEKEPP-------------DKDNPLLKLENVVTTPHIGASTR 284 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA + T +++ N KG N + Sbjct: 285 EAQMMVGMTVAEDIVNFFKGLPVKNAV 311 >UniRef50_A5D6D4 Phosphoglycerate dehydrogenase and related dehydrogenases n=3 Tax=Firmicutes RepID=A5D6D4_PELTS Length = 526 Score = 428 bits (1101), Expect = e-118, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 161/329 (48%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V +++ L+ + + G +++ D + ++ + + + + + Sbjct: 1 MKVLVLD--GVEEEGLKALRQEPGIQVDVKDKMSEDELVAAIGDYDGIIVRSATKVTARI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+ + +K + G +N+D+ AA G+ VV P + AVAEH I MM++L R I Sbjct: 59 IEKAAR--LKVVGRAGVGVDNIDVPAATARGILVVNAPEGNTLAVAEHTIAMMLSLARNI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A R + + G + GK GVIG G+IG A+ + +G M+++A+DPY + Sbjct: 117 PQANASLRAGKWDKKSFMGVELRGKVLGVIGLGRIGSAVAKRAQGMEMKVVAYDPYINEE 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LGV + L L ++D I++H PLT E+ ++L E AF MK+GV I+N +RG ++D Sbjct: 177 KAGLLGVTLLSLEELLKQADFITVHLPLTRESKYMLGEKAFSLMKDGVRIINCARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA A+K+ K+ +DV+E E + L N + T H Sbjct: 237 EQALYNAMKSGKVAGAALDVFEKEP--------------NTDSPLFEFKNFIATPHLGAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S++ + + KGE N + Sbjct: 283 TQEAQLSVATDVAREVVAALKGELVKNAV 311 >UniRef50_O29445 D-3-phosphoglycerate dehydrogenase n=8 Tax=cellular organisms RepID=SERA_ARCFU Length = 527 Score = 426 bits (1096), Expect = e-118, Method: Composition-based stats. Identities = 97/327 (29%), Positives = 165/327 (50%), Gaps = 17/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V + ++ + + + G E+E + E+ + EA+ + V++ Sbjct: 1 MKVLVAEPISEEAIDYMRK-NGLEVEVKTGMSREELIREVPKYEAIVVRSQTKVDAEVIQ 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K I G +N+D++AA + G+ VV P + + AEHAI +M+ R+I + Sbjct: 60 AAK--NLKIIGRAGVGVDNIDINAATQRGIVVVNAPGGNTISTAEHAIALMLAAARKIPQ 117 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A + ++ + + G + GKTAGVIG G++G + + K M +LA+DP+ S A Sbjct: 118 ADRSVKEGKWERKKFMGIELRGKTAGVIGLGRVGFEVAKRCKALEMNVLAYDPFVSKERA 177 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 ++GV+ VD TL + SDVI++H P T E L+ + FE+MK+GV++VN +RG ++D Sbjct: 178 EQIGVKLVDFDTLLASSDVITVHVPRTKETIGLIGKGQFEKMKDGVIVVNAARGGIVDEA 237 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A EA+K K+ + +DVYE E L NV+ T H A T Sbjct: 238 ALYEAIKAGKVAAAALDVYEKEPPS-------------PDNPLLKLDNVVTTPHIAASTR 284 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA ++ +++ N+ KG N + Sbjct: 285 EAQLNVGMIIAEDIVNMAKGLPVRNAV 311 >UniRef50_C8WVY8 D-3-phosphoglycerate dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WVY8_ALIAD Length = 529 Score = 426 bits (1096), Expect = e-118, Method: Composition-based stats. Identities = 94/329 (28%), Positives = 159/329 (48%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + T + + ++ G E+ L ++ + +A+ + +R V Sbjct: 1 MATKILVTDDISQAGIDILSGLQGAEVVVRTNLAPDELKEAIADADALVVRSQTRVTRDV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E KK +K I G +N+DL+AA G+ V+ P + A AEH MM++L R I Sbjct: 61 IESAKK--LKVIGRAGVGVDNIDLEAATRRGILVINAPDGNTIAAAEHTFAMMISLARHI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A++ N++ + G + GKT V+G G+IG + + K FGM +L +DP+ + Sbjct: 119 PAAHRDLLQGNWNRKKWIGVELRGKTLAVLGMGRIGTEVAKRAKAFGMTVLGYDPFLTEE 178 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGV+ DL T E+D I++H PLT E +H+++ QMK GV I+N +RG +ID Sbjct: 179 RAQSLGVKRCDLDTAIREADFITVHTPLTKETHHMIDAGRIAQMKEGVRIINCARGGIID 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A EAL+ ++ +DV+E E + L C NV+ T H Sbjct: 239 EVALAEALEAGRVAGAAIDVFEQEPL-------------PMDHPLRRCPNVVLTPHLGAS 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ + + + + +T + + Sbjct: 286 TVEAQENVAIQVAEEIVQVLRDDTFEHAV 314 >UniRef50_P52643 D-lactate dehydrogenase n=152 Tax=Bacteria RepID=LDHD_ECOLI Length = 329 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 329/329 (100%), Positives = 329/329 (100%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV Sbjct: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI Sbjct: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA Sbjct: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS Sbjct: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT Sbjct: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 AEALTSISQTTLQNLSNLEKGETCPNELV Sbjct: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 >UniRef50_A1RYE4 Glyoxylate reductase n=18 Tax=cellular organisms RepID=GYAR_THEPD Length = 339 Score = 420 bits (1082), Expect = e-116, Method: Composition-based stats. Identities = 93/335 (27%), Positives = 158/335 (47%), Gaps = 23/335 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDF--LLTEKTAKTANGCEAVCIFVNDDGSRP 59 + VY T+ + L + E + E+ + +A+ + D Sbjct: 3 RPKVYVTRIIPEPGLSMLKECCDVVVHESKDWPPSREELLRNIRDKDALLCLLTDKIDAE 62 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V++ +K I+ GF+++D+ A + G+ V P +AVAE +G+++ + RR Sbjct: 63 VMDAAP--NLKVISTYSVGFDHIDIPEATKRGIYVTHTPGVLTDAVAEFTVGLILAVTRR 120 Query: 120 IHRAYQRTRDANFSLEG----LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD- 174 I A + R + LTG + GKT G++G G+IGVA + L F +++L +D Sbjct: 121 IVEADKIIRTGQWDKPWNPYFLTGPELKGKTIGLVGLGRIGVATAKRLSSFDVKILYYDI 180 Query: 175 -PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + +E+ DL TL +SD++S+H PLT E YHL+NE +MK ++NT+ Sbjct: 181 ERRWDVETVIPNMEFTDLDTLLEKSDIVSIHVPLTKETYHLINEERLRKMKKTAYLINTA 240 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG ++D++A ++ALK I +DV+E E L+ NV+ Sbjct: 241 RGPVVDTEALVKALKEGWIAGAALDVFEQEPL-------------PPNHPLTKFDNVVLA 287 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H A T EA +++ +NL + KGE P + Sbjct: 288 PHIASATIEARQRMAELAARNLIAVLKGEMPPALV 322 >UniRef50_O27051 D-3-phosphoglycerate dehydrogenase n=16 Tax=Archaea RepID=SERA_METTH Length = 525 Score = 420 bits (1081), Expect = e-116, Method: Composition-based stats. Identities = 99/328 (30%), Positives = 157/328 (47%), Gaps = 19/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 ++ V ++K + ++ E + E+ +A+ + +R V+ Sbjct: 3 RMKVLIADSINEKGISELEEVAEV--VVNTTITPEELLDAIKDFDAIVVRSRTKVTREVI 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E + +K IA G +NVD+ AA + G+ V+ P VAEH+IG+M+ L R+I Sbjct: 61 EAAPR--LKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIA 118 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 A + ++ + G + GKT G+IG G+IG ++ K FGM ++ +DPY S Sbjct: 119 IADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEA 178 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A E+GV DL TL ESD++++H PLTPE HL++E F+ MK+ IVN +RG +ID Sbjct: 179 AEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDE 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A ALK+ +I +DV+E E L NV+ T H T Sbjct: 239 DALYRALKDGEIAGAALDVFEEEPPEG--------------SPLLELENVVLTPHIGAST 284 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +EA + + + +G N L Sbjct: 285 SEAQRDAAIIVANEIKTVFQGGAPRNVL 312 >UniRef50_B8HPZ0 D-3-phosphoglycerate dehydrogenase n=26 Tax=cellular organisms RepID=B8HPZ0_CYAP4 Length = 652 Score = 417 bits (1074), Expect = e-115, Method: Composition-based stats. Identities = 99/328 (30%), Positives = 157/328 (47%), Gaps = 20/328 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 V + D+ + + + ++ L E+ + +A+ I ++ V+E Sbjct: 128 PKVLVSDPIDQVGIDLLAQVAQVDVRT--DLSPEELIQIIPDYDALMIRSGTKVTQAVIE 185 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 + +K I G +NVD+ AA G+ VV P + A AEH + MM++L+R I Sbjct: 186 AA--NQLKIIGRAGVGVDNVDVPAATRKGIVVVNSPEGNTIAAAEHTLAMMLSLSRHIPA 243 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-SAAA 181 A Q + + + TG +Y KT GVIG GKIG + + + GM LLA+DPY + A Sbjct: 244 ASQSVKSGKWDRKSFTGVEVYKKTLGVIGLGKIGSHVATVARAMGMNLLAYDPYLSNERA 303 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 ++G V+L LF+E+D I+LH P TPE HL+ +MK I+N +RG +ID Sbjct: 304 EQIGCRLVNLDLLFAEADYITLHLPKTPETQHLIKAETLARMKPTARIINCARGGIIDEA 363 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHN-VLFTGHQAFLT 300 A +EALK KI +DV+ENE L + V+ T H T Sbjct: 364 ALVEALKEGKIAGAALDVFENEPLG--------------ESPLLSLGKEVVLTPHLGAST 409 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA T+++ + + +L G+ + + Sbjct: 410 EEAQTNVAIDVAEQIRDLFLGKPVRSAV 437 >UniRef50_A7HM61 Glyoxylate reductase n=6 Tax=cellular organisms RepID=A7HM61_FERNB Length = 317 Score = 413 bits (1062), Expect = e-114, Method: Composition-based stats. Identities = 105/332 (31%), Positives = 162/332 (48%), Gaps = 22/332 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDF-LLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + V+ T +K + + E F ++ + L E+ K A +A+ + D + + Sbjct: 1 MRVFVTYAIPEKGINMLKERFEVDVYTGEEFLSKEEMIKRAEYADAIVTQLRDPIDKEFI 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 LKK K IA G+NN+D++AAKE G+ V P EA A+ A +++ + RRI Sbjct: 61 YSLKKA--KIIANYAVGYNNIDIEAAKERGIYVTNTPGVLTEATADIAFALILAVARRIV 118 Query: 122 RAYQRTRDAN---FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + + R+ + + G+ +YGKT GVIG G+IG A+ R GFGM ++ ++ Sbjct: 119 ESDKFVREGKFVGWKPKLFLGYDLYGKTLGVIGMGRIGQAVARRALGFGMNIVYYNRNRL 178 Query: 179 AAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 +E +YV++ L SD ISLH PLT E YHL+N+ +MK ++VNT+RG Sbjct: 179 PEEIEKQYNAKYVNIDELVEISDYISLHTPLTKETYHLINKERIAKMKPNAILVNTARGP 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D QA EALK ++I G DVYENE L L NV+ H Sbjct: 239 VVDEQALYEALKERRIAGAGFDVYENEPVLTPG--------------LEKLDNVVLLPHI 284 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E +S+ N+ G+ N + Sbjct: 285 GSATYETRDKMSEIVAINVMEALDGKRPSNCV 316 >UniRef50_P44501 2-hydroxyacid dehydrogenase homolog n=103 Tax=cellular organisms RepID=DDH_HAEIN Length = 331 Score = 412 bits (1060), Expect = e-114, Method: Composition-based stats. Identities = 231/329 (70%), Positives = 280/329 (85%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A+YSTK YD+KY++ +N + F+LEFFDF+L E T + A CE VCIFVND+GSR V Sbjct: 1 MKIAIYSTKSYDRKYIELINAKYNFDLEFFDFMLNESTVRLAEHCEVVCIFVNDNGSRKV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L GVK +ALRCAGFNNVDL AA+ELG++VVRVPAY PEAVAEH IG+MMTLNRRI Sbjct: 61 LEKLAALGVKIVALRCAGFNNVDLKAAQELGIQVVRVPAYSPEAVAEHTIGLMMTLNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAYQRTR+ANFSLEGL GF MYG+T GVIGTGKIG+A++RILKGFGM +LA+DP+ + Sbjct: 121 HRAYQRTREANFSLEGLIGFNMYGRTVGVIGTGKIGIAVMRILKGFGMNILAYDPFKNPV 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 ELG +YV+L L+++S VI+LHCP TPENYHLLN AF +MK+GVMIVNTSRG+LID+ Sbjct: 181 VEELGGQYVELDELYAKSHVITLHCPATPENYHLLNCEAFAKMKDGVMIVNTSRGSLIDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QAAI+ALK +KIG+LGMDVYENERDLFFEDKSN+VIQDD+FRRLS+CHNVL TGHQAFLT Sbjct: 241 QAAIDALKQRKIGALGMDVYENERDLFFEDKSNEVIQDDIFRRLSSCHNVLLTGHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 EALT+I+ TL N+ L+ G+ C N ++ Sbjct: 301 EEALTNIADVTLSNIYKLKSGKVCENIVL 329 >UniRef50_A3DM01 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=5 Tax=Archaea RepID=A3DM01_STAMF Length = 311 Score = 411 bits (1058), Expect = e-113, Method: Composition-based stats. Identities = 99/322 (30%), Positives = 164/322 (50%), Gaps = 19/322 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + +K L+++ S GF++ + ++ ++ + EA+ + SR V+E Sbjct: 2 VKILVAAPLHEKALEKLR-SAGFQIVYEEYPSEDRLVELIKDVEAIIVRSKPKVSRRVIE 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K +K IA G +N+DLDAA E G++V PA ++VAE AIG+M+ + R+I Sbjct: 61 AAEK--LKVIARAGVGLDNIDLDAANEKGIQVFNAPAAPTQSVAELAIGLMIDVLRKIAF 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFD--PYPSA 179 A ++ R+ ++ + G + G G+IG G+IG A+ RI GFGM+++ +D P Sbjct: 119 ADRKMREGVWAKKQCLGHELRGIVLGIIGMGRIGTAVARIAYHGFGMKIIYYDVRRCPKD 178 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 EL + VDL TL +D++S+H PL P HL+NE MK +++NT+RG ++D Sbjct: 179 VEKELDAKCVDLETLLKTADIVSIHVPLVPSTKHLINEEKLRLMKKSAILINTARGGVVD 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A ++ALK I G+DV+E E L+ NV+ T H Sbjct: 239 TDALVKALKEGWIAGAGLDVFEEEPL-------------PPNHPLTKLDNVVLTPHIGAN 285 Query: 300 TAEALTSISQTTLQNLSNLEKG 321 T EA ++ + KG Sbjct: 286 TVEAQERAGIEVVEKIIEFFKG 307 >UniRef50_C6HZG9 D-3-phosphoglycerate dehydrogenase n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HZG9_9BACT Length = 537 Score = 409 bits (1053), Expect = e-113, Method: Composition-based stats. Identities = 85/327 (25%), Positives = 149/327 (45%), Gaps = 17/327 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + + ++ + + ++ GFE+ L ++ + + I + VL Sbjct: 6 KIKILVSDPISEEGIN-IFKNAGFEVTVKAKLSPDELKAELAHYDGLVIRSGTKVTAHVL 64 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E + +K I AG +NVDL AA G+ V+ P + AEH + MMM++ RRI Sbjct: 65 EGATR--LKVIGRAGAGLDNVDLPAATNRGIVVMNTPGGNTITTAEHTVSMMMSMARRIP 122 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A R + G + KT G++G GKIG + + +G M ++A+DP+ +A Sbjct: 123 QANASNRSGKWEKSKFMGIELAHKTLGILGMGKIGSHVAHVAQGLLMNVIAYDPFLTAES 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A GV V + LF+++D+I++H PLTPE +L++ A+ +MK GV IVN +RG +++ Sbjct: 183 AARQGVTPVTVEELFAKADIITVHTPLTPETTNLISSASIAKMKKGVYIVNCARGGIVNE 242 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +AL++ + DV+ E L N + T H T Sbjct: 243 ADLAKALESGHVAGAAFDVFAEEPPS-------------PDNPLLKLDNFISTPHIGAAT 289 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNE 327 EA +++ + + Sbjct: 290 KEAQENVALAVADQMVDYLAKGIIRYA 316 >UniRef50_A9KHK7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KHK7_CLOPH Length = 346 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 169/327 (51%), Positives = 227/327 (69%), Gaps = 5/327 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+A + TK YDK++ + + F++++++ L TAK A+GC+AV FVND + + Sbjct: 3 KVACFDTKSYDKEWFDR-KNNGEFQIKYYENKLNADTAKLAHGCQAVIAFVNDSIDKETI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 EEL + G+K IA+RCAG+NN+D A + + VVRVP Y P AVAEHA+ +++ LNR+IH Sbjct: 62 EELYQLGIKVIAMRCAGYNNIDFKEAYQK-IAVVRVPGYSPHAVAEHAMALLLCLNRKIH 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 RAY RTRD NFSL+GL GF +Y KT GV+GTGKIG + I KGFGMR+LA+D YP + Sbjct: 121 RAYIRTRDYNFSLKGLIGFDLYKKTIGVVGTGKIGQVFIDICKGFGMRVLAYDLYPDHSK 180 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +EYV L TLFSESDVISLHCPLT E+ H++N + MK +I+NTSRGALIDS+ Sbjct: 181 ---DIEYVSLETLFSESDVISLHCPLTEESKHMINAETLKLMKQDAVIINTSRGALIDSE 237 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A + ALK ++I G+DVYE E DLFFED S + +DDV L NV+ T HQ FLT Sbjct: 238 ALLVALKEERIAGAGLDVYEEESDLFFEDNSGTIPKDDVLSLLVGLPNVIITSHQGFLTN 297 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EAL++I++TT++NL E+ NE+ Sbjct: 298 EALSNIAETTIENLRAYFHDESLINEI 324 >UniRef50_B4D991 D-3-phosphoglycerate dehydrogenase n=3 Tax=Verrucomicrobia RepID=B4D991_9BACT Length = 530 Score = 406 bits (1046), Expect = e-112, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 148/329 (44%), Gaps = 17/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V +K + ++ ++ L ++ A+ + + V+ Sbjct: 3 KPKVLVADPIAQKGIDELANGGSLDVTVKIGLKPDELLAIIGEFNALVVRSETKANAKVI 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E +K I G +NVD+DAA + G+ V+ P + + AEHA +M++ R I Sbjct: 63 EAA--TNLKVIGRAGVGVDNVDVDAATKRGIIVMNTPGGNTISTAEHAFSLMVSTARNIP 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-A 180 +A + + + G +Y KT ++G G+IG + R FGMR+LA+DPY SA Sbjct: 121 QADASVKSGKWDRKTFVGVELYNKTLAILGMGRIGTEIARRAIAFGMRVLAYDPYLSASR 180 Query: 181 ALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A L VE V L + ++D I+LH PLT E ++LN + K GV IVN +RG LID Sbjct: 181 ARSLQVELVESLDLIIPQADFITLHMPLTAETKYMLNAERLAKTKKGVRIVNCARGGLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A +EALK++++ + +DV+E E L N++ T H Sbjct: 241 EAALVEALKSKQVAAAALDVFEAEPL-------------PAESPLRGLPNLILTPHLGAS 287 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA + + + N + Sbjct: 288 TAEAQEGVGIEVAEQIRAALLSGEIRNAV 316 >UniRef50_B6YWH0 Glyoxylate reductase n=95 Tax=cellular organisms RepID=GYAR_THEON Length = 334 Score = 406 bits (1045), Expect = e-112, Method: Composition-based stats. Identities = 89/337 (26%), Positives = 158/337 (46%), Gaps = 25/337 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFD-FLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK V T++ + ++ + E F E+ + + E + +A+ +++ Sbjct: 1 MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V + + +K +A G++N+D++ A ++G+ + P A A+ A +++ RR Sbjct: 61 VFDAAPR--LKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARR 118 Query: 120 IHRAYQRTRDANFSLEG-------LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLA 172 + A + R + G G+ +YG+T G++G G+IG A+ R KGFGMR+L Sbjct: 119 LIEADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILY 178 Query: 173 FDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVN 231 ELG E++ L L ESD + L PLT E YH++NE + MK ++VN Sbjct: 179 NSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVN 238 Query: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVL 291 +RG ++D++A ++AL+ I G+DV+E E L + NV+ Sbjct: 239 IARGKVVDTEALVKALREGWIAGAGLDVFEEEPYYH--------------EELFSLDNVV 284 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T A +++ +NL + GE P + Sbjct: 285 LAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTLV 321 >UniRef50_Q1AXS3 D-3-phosphoglycerate dehydrogenase n=2 Tax=Actinobacteria (class) RepID=Q1AXS3_RUBXD Length = 527 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 86/328 (26%), Positives = 149/328 (45%), Gaps = 20/328 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V T++ ++ ++ + FE++ L + + + + + + V+E Sbjct: 1 MRVLVTEKLAERGVELLRRE--FEVDVLLGLSPGELLERIGEYDGLIVRSATKVTAEVIE 58 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 + +K I G +N+D++AA + G+ V P + A AEH +G+M+ + RRI Sbjct: 59 AAGR--LKAIGRAGIGVDNIDIEAATKRGILVANAPESNTVAAAEHTLGLMLAVARRIPA 116 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A R ++ G + KT G++G G +G + R G GMR+LA+DPY S + Sbjct: 117 ADASLRRGEWNRAAFKGVEVAEKTLGLVGLGHVGSIVARGALGMGMRVLAYDPYVSEERM 176 Query: 183 E-LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + VE L +F E+D +SLH P TP+ ++ E +MK ++N +RG ++D Sbjct: 177 RSMNVERAGSLEEIFEEADFVSLHVPRTPQTTGMVGEEELARMKPTAYLINVARGGIVDE 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A ALK +I +DV+ E L A NV+ T H T Sbjct: 237 TALYNALKQGEIAGAALDVFAEEPTT--------------DSPLFALPNVVVTPHLGAST 282 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 AEA T + ++ +GE + + Sbjct: 283 AEAQDRAGVTAAEQVAAALRGEVPIHAI 310 >UniRef50_Q8Z0N3 D-lactate dehydrogenase n=9 Tax=Bacteria RepID=Q8Z0N3_ANASP Length = 341 Score = 402 bits (1034), Expect = e-110, Method: Composition-based stats. Identities = 188/328 (57%), Positives = 247/328 (75%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+STK YD+++L+ N EL FF+ L + TA A G AVC+FV+D Sbjct: 1 MKVAVFSTKAYDRQFLEAANAPKHHELAFFEPRLNQDTAILAAGFPAVCVFVHDQVDAAT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G + I LRCAGFNNVDL AA +LG+ VVRVPAY P VAEHA+G++++LNR+I Sbjct: 61 LEILASRGTRLIVLRCAGFNNVDLKAANKLGVTVVRVPAYSPYGVAEHAVGLILSLNRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY R R+ NF+L+GL GF + G+T G+IGTGKIG+ + +I+KGFG RLLA+D Y + Sbjct: 121 HRAYNRVREGNFALDGLLGFNINGRTVGIIGTGKIGLILGQIMKGFGCRLLAYDVYRNPE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG EYV+LP LF+ SD+ISLHCPL P+ +HL+N A EQ+K GVM++NTSRGALI + Sbjct: 181 MESLGGEYVELPELFANSDIISLHCPLMPQTHHLINAEAIEQVKPGVMLINTSRGALIHT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 QA IE LK KIGSLG+DVYE E +LFFED S ++IQDD+F+RL+ NVL TGHQAF T Sbjct: 241 QAVIEGLKTGKIGSLGVDVYEQESELFFEDLSGEIIQDDIFQRLTTFPNVLITGHQAFFT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +AL +I++TTL N++++E+G +CPNE+ Sbjct: 301 EDALRNIAETTLNNIADIEQGRSCPNEI 328 >UniRef50_A0LMX1 D-3-phosphoglycerate dehydrogenase n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LMX1_SYNFM Length = 525 Score = 401 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 91/327 (27%), Positives = 143/327 (43%), Gaps = 17/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V + L + + G +++ D E+ +AV + + ++E Sbjct: 1 MKVLICDGMHEVGLSILRAAEGIDVDVPDQPGAEEIKAMLPDYDAVIVRSRTRITAELIE 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 + +K I G +N+D+ AA G V+ P + A AEH I MM+ L R I + Sbjct: 61 NAPR--LKVIGRAGTGVDNIDVKAASARGALVMNTPGANATAAAEHTIAMMLALARHIPQ 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A Q R+ + + G ++ +T G+IG GKIG + M +L DPY A Sbjct: 119 ATQSMREGRWDKKRFMGTELFHQTLGIIGLGKIGSIVADRALSMKMDVLGHDPYIIPEAA 178 Query: 183 E-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LGVE+V L L + SD ++LH P T E +LN + K GV I+N +RG LID Q Sbjct: 179 AILGVEWVPLDELLARSDFLTLHTPSTSETVRILNRETLARTKPGVRILNCARGGLIDEQ 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A E L N +G +DV+E E V L NV+FT H + Sbjct: 239 ALYEFLLNGHVGGAALDVFEQEPP--------------VDSPLLKLENVIFTPHLGASSY 284 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 +A ++++ + + N + Sbjct: 285 QAQANVARAIATQIVDYLLYGIIRNAV 311 >UniRef50_A5G1V9 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A5G1V9_ACICJ Length = 528 Score = 401 bits (1032), Expect = e-110, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 147/327 (44%), Gaps = 18/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 V + + + + + G ++ L + + + + I +R +L+ Sbjct: 2 PKVLISDKLSPAAID-IFKRRGIDVTVKTGLAPAELREIIGEFDGLAIRSATKVTRELLD 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K I G +NVD+ +A G+ V+ P + AEHAIG+M L R + Sbjct: 61 AA--TNLKVIGRAGIGVDNVDVKSATARGVVVMNTPYGNAITTAEHAIGLMFALARELPE 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A T+ + G + GKT G+IG G IG + G MR+LA+DPY + A A Sbjct: 119 ASASTKAGKWEKNRFMGVELTGKTLGLIGAGNIGSIVADRALGLKMRVLAYDPYLTEARA 178 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LGVE DL T+ + +D I+LH PLT + ++L+ + + K GV I+N +RG L+D Sbjct: 179 TTLGVEKADLDTVLARADFITLHTPLTEQTRNILSRESIARTKPGVRIINCARGGLVDEA 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +ALK+ + +DV+E E L A NV+ T H T Sbjct: 239 ALYDALKSGHVAGAALDVFEVEPAK--------------ESPLFALPNVVCTPHLGAATT 284 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + +S+ N + Sbjct: 285 EAQENVALQVAEQISDFLLTGAVTNAI 311 >UniRef50_D1JIG3 D-3-phosphoglycerate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JIG3_9ARCH Length = 542 Score = 398 bits (1024), Expect = e-109, Method: Composition-based stats. Identities = 88/326 (26%), Positives = 156/326 (47%), Gaps = 19/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V T ++ ++++ E ++E L E A +A+ I ++ +++ Sbjct: 12 KVLVTDNISEEGIKKLREFGDVDVEL--DLSKEDLAACIANYDALVIRSGTTVTKEIIDA 69 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K+ +K I G +N+D++ A E G+ VV P + + AEH M+++++R+I A Sbjct: 70 GKR--LKVIGRAGVGVDNIDVERATEKGILVVNSPEANSISAAEHTFAMLLSISRKIPAA 127 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 + + + G + GK G IG G++G + + KGFGMR++A DP+ SAA A Sbjct: 128 NVSLKSGKWERKKHMGVEVNGKVLGTIGLGRVGSEVAKRAKGFGMRVVAHDPFISAAKAK 187 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ELG+ + + + +D I+LH PLT + +H++ + FE MK+GV ++N +RG ++D A Sbjct: 188 ELGITLLGFKEVLATADFITLHTPLTKDTHHMIGKGEFELMKDGVRVINCARGGILDEDA 247 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 EA+K K+ +DV+E E + L V+ T H T E Sbjct: 248 LKEAIKAGKVAGAALDVFEQEPPNNDD--------------LLELEEVIVTPHLGASTTE 293 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A + + + + N L Sbjct: 294 AQRAAAVVIADEVIGALSNKPVKNAL 319 >UniRef50_B2V7I1 D-3-phosphoglycerate dehydrogenase n=8 Tax=Aquificales RepID=B2V7I1_SULSY Length = 529 Score = 398 bits (1023), Expect = e-109, Method: Composition-based stats. Identities = 87/327 (26%), Positives = 150/327 (45%), Gaps = 16/327 (4%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V T K L+ ++ +L++ + + + +A+ ++ +LE Sbjct: 3 KVLVTDDISPKGLEILSNDEEIDLDYQPEIKFNELLEIIKDYDAIITRSRTPVTKELLER 62 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K +K I G +NVDL+ A G+ VV P + AE + + + R++H A Sbjct: 63 AEK--LKVIGRAGVGVDNVDLEEASRRGILVVNTPGANTIGAAEITMAHLYAVLRKLHLA 120 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 + + + G + GK G+IG G +G + K G +++A+DPY P Sbjct: 121 HDSVKAGEWKRSKFMGEELDGKVVGIIGLGNVGSQVAIRCKAAGAKVIAYDPYIPKEKGD 180 Query: 183 ELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LGVE + DL L SD+I+LHCPLT E +++ + F+ MK GV +N +RG ++D Sbjct: 181 RLGVEIIDDLHELIKISDIITLHCPLTEETRNMIGKKEFDLMKKGVYFINCARGGIVDED 240 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A++ KI LG+DV+ E D+ RRL N+ + H T Sbjct: 241 ALYDAIQEGKIAGLGLDVFSKEPP------------DERIRRLFEFPNISLSPHIGANTY 288 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 E+ +++ Q + KG+ + Sbjct: 289 ESQDNVAIKIAQYVIAALKGQFVEVAV 315 >UniRef50_C6PIV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thermoanaerobacter italicus Ab9 RepID=C6PIV3_9THEO Length = 325 Score = 396 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 157/329 (47%), Gaps = 20/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK V +++ +++ E G E+ + E EA+ + ++ + Sbjct: 1 MK-KVLLSEEIHPDG-RKILEEKGIEIITAPDVKEETLISMVRDVEAIIVRSKAKITKGI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +K I+ AG +N+D++AA E G+ V +PA + +VAEH I M++ L +++ Sbjct: 59 IENAPK--LKIISRTGAGVDNIDVNAATEKGILVCNLPAVNSLSVAEHTIAMILHLAKQL 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 Q R+ N+ + GKT G++G G IG+ + + G GM+++A+DPY Sbjct: 117 SLMDQAVRNGNWEMRNSNISVEVEGKTLGIVGMGNIGILVAKKCHDGLGMKIVAYDPYVK 176 Query: 179 AAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + +VD L LF ESD ++LHCP PE ++ MK ++N +RG + Sbjct: 177 EKFKDYDYRFVDSLEELFKESDFVTLHCPDIPETRGMITRELIYSMKPTAYLINVARGTV 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID QA IEALK ++I G+DV++ E L NV+ + H A Sbjct: 237 IDEQALIEALKEKRIAGAGLDVFQQEPPSR-------------DNELLRLENVILSPHSA 283 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPN 326 LT EA ++ +Q + + +G Sbjct: 284 ALTKEATVRMAVEAVQAVIDYFEGRQPKY 312 >UniRef50_Q31F74 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=11 Tax=cellular organisms RepID=Q31F74_THICR Length = 352 Score = 396 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 176/318 (55%), Positives = 235/318 (73%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+A +S + DK + + +S E F + L+EKT G EA+C+FVNDD S V Sbjct: 19 MKVAFFSATKTDKNFFETNRQSDSLEFVFLEAHLSEKTVPLVQGVEAICVFVNDDLSEEV 78 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +L +GVK IALRCAGFNNVD++AA++ GL ++RVPAY P AVAEHA+ +MM+LNR+ Sbjct: 79 IRQLASYGVKLIALRCAGFNNVDIEAARQHGLTILRVPAYSPMAVAEHALALMMSLNRKT 138 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +RAY R RD NF+LEGL GF M+ KTAG++GTG+IG+ M RIL G G+ +L +DP+P+ Sbjct: 139 YRAYNRIRDGNFALEGLLGFDMFQKTAGIMGTGRIGLEMTRILTGLGLNVLVYDPFPNQQ 198 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+E G EYV L TL+ +SD+ISLH PL PE +H+++ A QMK GVM++NTSRGAL+D+ Sbjct: 199 AIEYGAEYVSLATLYQQSDIISLHMPLLPETHHIIDADAIAQMKPGVMLINTSRGALMDA 258 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I LK +KIG LG+DVYE E +LFFED S ++IQDD F RL + NVL TGHQAF T Sbjct: 259 DALIAGLKTEKIGYLGIDVYEQEENLFFEDHSEEIIQDDAFERLVSFPNVLITGHQAFFT 318 Query: 301 AEALTSISQTTLQNLSNL 318 EALT+I+QTT++N+ + Sbjct: 319 QEALTNITQTTIENILDY 336 >UniRef50_B3RTC6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RTC6_TRIAD Length = 520 Score = 396 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 85/322 (26%), Positives = 149/322 (46%), Gaps = 18/322 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D K + V E+ G E+ L + + + + + V++ Sbjct: 6 KVLISDSVDPK-CKSVLEAKGIEVTLNTKLSPAELVAEIPNYDGLIVRSATKVTAEVIKA 64 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K +K I G +N+D+ AA E G+ V+ P + + AEH +M+ L R++ +A Sbjct: 65 GK--NLKIIGRAGTGVDNIDIKAATECGVIVMNTPGGNTLSAAEHTCTLMVCLARQVPQA 122 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAAAL 182 R+ + + G + GKT G+IG G+IG + ++ FG+R + +DP P+ AA Sbjct: 123 AASMREGRWDRKKYMGIELMGKTLGIIGLGRIGREVATRMQSFGVRTVGYDPIVPAEAAK 182 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E VE+ +L L+ E D I++H PL P+ LL + F + K GV ++N +RG +ID A Sbjct: 183 EFDVEFFELNDLWPECDFITVHTPLIPQTRGLLGDETFAKCKKGVRVINCARGGIIDEAA 242 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + AL++ + +DV+E E L NV+ H T E Sbjct: 243 LLRALQSGQCAGAALDVFEQEPPQNT--------------ELVQHPNVIPVCHLGASTVE 288 Query: 303 ALTSISQTTLQNLSNLEKGETC 324 A + ++ + + +G++ Sbjct: 289 AQSRVAVEIAEQFVDFNEGKSL 310 >UniRef50_Q2G4V7 D-3-phosphoglycerate dehydrogenase n=146 Tax=cellular organisms RepID=Q2G4V7_NOVAD Length = 540 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 90/328 (27%), Positives = 149/328 (45%), Gaps = 18/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V + + D + E G +++ E+ + + I + ++ +L Sbjct: 15 KPKVLISDKMDPNAARIFTE-MGCDVDVITGETPEQLIARIGEYDGLAIRSSTKVTKAIL 73 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + +K I G +NVD+ AA G+ V+ P + AEHAI MM L R+I Sbjct: 74 DAA--TNLKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIP 131 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 A +T+ + G G + GKT G+IG G IG + G M+++AFDP+ + Sbjct: 132 EANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKVVAFDPFLTPER 191 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+E+GVE DL TL +++D I+LH PLT + ++L+ + K GV I+N +RG L+D Sbjct: 192 AVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRIINCARGGLVDE 251 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A +AL + + +DV+E E L N + T H T Sbjct: 252 AALKDALDSGHVAGAALDVFETEPAK--------------ESPLFGTPNFICTPHLGAST 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + +++ N L Sbjct: 298 TEAQVNVALQVAEQMADFLVTGGVTNAL 325 >UniRef50_UPI0001C41AB7 phosphoglycerate dehydrogenase SerA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41AB7 Length = 524 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 96/328 (29%), Positives = 156/328 (47%), Gaps = 20/328 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + ++K ++ + E ++ + E+ +T +A+ I V+E Sbjct: 1 MKALVADAINEKGIENLKEVCDVVVDT--SITPEELLETIGEYDAILIRSRTKLPAEVIE 58 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 + +K IA G +NVD++AA + G+ VV P VAEH +G++++ R+I Sbjct: 59 KA--DNLKIIARAGVGVDNVDVNAATKKGIMVVNAPESTSITVAEHTMGLILSTIRKIAI 116 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAA 181 A + T+ + + G + KT GVIG G+IG ++ K F M +A+DPY P A Sbjct: 117 ADKSTKAGKWEKKAFMGMELRNKTLGVIGMGRIGSQVVNRCKAFEMDAIAYDPYLPPEVA 176 Query: 182 LELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +GVE Y D+ + + +D+I++H PLTPE H ++ F+ MK+ +I N +RG +ID Sbjct: 177 KNMGVELYEDIEDVLTRADIITIHVPLTPETEHSISTEQFKMMKDTALIFNCARGGVIDE 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A EAL N +I G+DVYE E +L N++ T H A T Sbjct: 237 DALYEALVNGEILGAGLDVYEKEPAT--------------NNKLFELDNIVCTPHIAAST 282 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA + + L KG N + Sbjct: 283 KEAQRDAAIIVANEVITLFKGGMPKNII 310 >UniRef50_C5K2M9 D-lactate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5K2M9_AJEDS Length = 392 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 153/330 (46%), Positives = 214/330 (64%), Gaps = 1/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S ++Y++ L++ N+ F +EL +F L+ +T A G AV FV+D V Sbjct: 59 MKVAVFSFQEYERTALERFNQRFQYELVYFSAPLSTETVSLAAGSVAVSTFVSDHVDAEV 118 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G+K +ALRCAG ++VDL AA E + V+RVPAY A+AE+ IG+++TLNR I Sbjct: 119 LEVLADAGIKLVALRCAGHDSVDLQAASENHITVMRVPAYSSYAIAEYTIGILLTLNRNI 178 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 H+A R R NF L GL G +YGKT G+IGTG+IG A+ LK GFG R++A D Sbjct: 179 HKASTRVRTGNFDLNGLVGSNIYGKTVGIIGTGRIGAAVATTLKLGFGCRVIANDLDAHL 238 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++GV+YVD TLF SD I LHCPLT + H++N + + MK V++VNTSRG LID Sbjct: 239 ELEKIGVDYVDQDTLFRSSDFICLHCPLTKQTRHIINPESLQLMKPEVILVNTSRGGLID 298 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A +++L+N +I +DVYE E L F+ S + I D +RL + NV+ TGHQAFL Sbjct: 299 TPALLDSLENGRIRGCALDVYERENSLLFQKSSMEEIDDPTLKRLVSLPNVILTGHQAFL 358 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EA+ +I++TTL+N+ N G+ N V Sbjct: 359 TQEAIDAIAETTLKNIQNFLAGKVDVNRAV 388 >UniRef50_A7IAB7 D-3-phosphoglycerate dehydrogenase n=11 Tax=cellular organisms RepID=A7IAB7_METB6 Length = 534 Score = 395 bits (1017), Expect = e-108, Method: Composition-based stats. Identities = 85/325 (26%), Positives = 153/325 (47%), Gaps = 19/325 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + + ++ L + E+ F ++ L ++ +A+ + + + V+ Sbjct: 6 ILVSDPLAEEGLVILKEA--FTVDVKTDLKEDELCGVIGEYDALIVRSGTEVTAKVITAG 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 KK +++I G +NVD+DAA G+ V P + A EH + MM++L R I +A Sbjct: 64 KK--LRFIGRAGVGVDNVDVDAATRQGVIVANAPEGNTLAATEHTMAMMLSLARNIPQAN 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + + G + KT G++G G+IG + + M+ +A+DP+ S A + Sbjct: 122 ASLKKKEWKRSKFMGVELNEKTLGIVGFGRIGREVAKRANAMDMKCVAYDPFISKERAAQ 181 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LGV + L LF+ +DVI++H PL E H++N + MK+GV I+N +RG +ID A Sbjct: 182 LGVRVMSLAELFTVADVITVHTPLIKETKHVINAKSIATMKDGVRIINCARGGIIDEAAL 241 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 ++A+K+ K+ +DV+E E L L + NV+ T H T EA Sbjct: 242 VDAIKSGKVAGAALDVFETEPPL--------------ESPLLSLDNVIVTPHLGASTVEA 287 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ + + G + + Sbjct: 288 QKNVAIQVAKQCVEVLNGGSAKYVV 312 >UniRef50_UPI0001C430A3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Bacillus pseudofirmus OF4 RepID=UPI0001C430A3 Length = 540 Score = 395 bits (1016), Expect = e-108, Method: Composition-based stats. Identities = 84/328 (25%), Positives = 150/328 (45%), Gaps = 21/328 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K + + ++ L + E+ E + +A+ + + +L Sbjct: 18 KYHILVSDAMSQEGLLPLLENANVHCVEAYVDEVEDLTQ----FDALLVRSATKVTEELL 73 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +++ +K +A G +N+DLDAA + G+ VV P + + AEH M+ +L R+I Sbjct: 74 QKMP--NLKIVARAGVGVDNIDLDAATKHGVVVVNAPDGNTISTAEHTFAMISSLLRKIP 131 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A + ++ + G + GKT G++G G+IG + + + F M LL FDP+ + A Sbjct: 132 QANASIKAGEWNRKAFQGSELRGKTLGIVGFGRIGTQIAKRARAFEMSLLVFDPFLTKAR 191 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A ++GV L + ++SD+I++H PLT E +L + K GV ++N +RG +ID Sbjct: 192 AEKIGVTPASLDDVLAQSDIITVHTPLTKETKGILGMENIAKTKQGVFLINCARGGIIDE 251 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A L N I +DV+E E + L NV+ T H A T Sbjct: 252 SALKHYLANGHIAGAALDVFEEEPAQ--------------DKELLEFDNVIATPHIAAST 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + + +G+ N + Sbjct: 298 KEAQLNVASQVSEEVIRFLEGQPATNSI 325 >UniRef50_P30799 2-hydroxyacid dehydrogenase homolog n=7 Tax=Bacteria RepID=DDH_ZYMMO Length = 331 Score = 394 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 166/331 (50%), Positives = 236/331 (71%), Gaps = 2/331 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A++S+K YD +++ NE +G +L F + LT++TA+ A EAVCIFVND+ + V Sbjct: 1 MRVAIFSSKNYDHHSIEKENEHYGHDLVFLNERLTKETAEKAKDAEAVCIFVNDEANAEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G+K +ALRCAG+NNVDLDAAK+L +KVVRVPAY P +VAE+A+GM++TLNR+I Sbjct: 61 LEILAGLGIKLVALRCAGYNNVDLDAAKKLNIKVVRVPAYSPYSVAEYAVGMLLTLNRQI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 R +R R+ NFSLEGL G ++ KT G+IG G IG I+ GFG ++A+ P+P Sbjct: 121 SRGLKRVRENNFSLEGLIGLDVHDKTVGIIGVGHIGSVFAHIMTHGFGANVIAYKPHPDP 180 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A ++G + L + SD+ISLHCPLTPEN+H++NE + K G +VNTSRG L+ Sbjct: 181 ELAKKVGFRFTSLDEVIETSDIISLHCPLTPENHHMINEETLARAKKGFYLVNTSRGGLV 240 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D++A I++LK + +G DVYE E LFFE+ ++D+I+DD+ RL A NV+FTGHQAF Sbjct: 241 DTKAVIKSLKAKHLGGYAADVYEEEGPLFFENHADDIIEDDILERLIAFPNVVFTGHQAF 300 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 LT EAL++I+ + LQ++S+ E G+ P+ LV Sbjct: 301 LTKEALSNIAHSILQDISDAEAGKEMPDALV 331 >UniRef50_A2STQ1 D-3-phosphoglycerate dehydrogenase n=5 Tax=cellular organisms RepID=A2STQ1_METLZ Length = 527 Score = 394 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 152/329 (46%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V + + + + + E++ L ++ K +A+ + + + Sbjct: 1 MSFKVLVSDPLAAEGIAILKDFC--EVDEKADLSEDELVKIIGEYDALIVRSGTQVTARI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +KYI G +N+D +AA + G+ V P + A EH I MMM + R I Sbjct: 59 IEAADK--MKYIGRAGVGVDNIDCEAATKKGIIVSNAPEGNTLAATEHTIAMMMAMARNI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSA 179 +A + + G M GK GV+G G+IG + + + M ++A+DP+ P+ Sbjct: 117 PQASASLKKGEWKRSKFMGNEMNGKVLGVVGFGRIGREVAKRAQALQMTVIAYDPFIPAE 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +GVE + + LF+++DVI++H PL P HL+N+ + MK GV ++N +RG +ID Sbjct: 177 VGAAMGVEMMSVAELFTKADVITVHTPLIPSTTHLVNKESIATMKTGVRMINCARGGIID 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + +A+ + K+ +DV+E E L +V+ T H Sbjct: 237 EKDLYDAIVSGKVAGAALDVFETEPPT--------------ESPLLKLDSVIVTPHLGAS 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ + ++ KG + + + Sbjct: 283 TVEAQKNVAISVAHQCIDVLKGGSAKSAV 311 >UniRef50_B2JFX7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=cellular organisms RepID=B2JFX7_BURP8 Length = 335 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 169/329 (51%), Positives = 220/329 (66%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++S++QYD + N +FG+EL F + L TA A G + VC FVND Sbjct: 1 MRMMLFSSRQYDIDTFTEANAAFGYELHFQESHLDADTAVLAEGYDVVCPFVNDSVDAAT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE L G + IALR AGFN+VDL AA+ LG+ VVRVPAY P AVAEHA+G+++ LNR++ Sbjct: 61 LEALHAGGARLIALRSAGFNHVDLAAAQRLGIGVVRVPAYSPYAVAEHAVGLILALNRKL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA- 179 RA RTR+ +FSL GL GF ++GKT GVIGTG IG RI+ GFGM++LA DP P A Sbjct: 121 ARAVARTREGDFSLNGLLGFDLHGKTVGVIGTGIIGRCFGRIMAGFGMQVLAHDPGPPAT 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 L LG YV L TL ++SD++SLHCPL P YHL++ A +MK G M++NT RG L++ Sbjct: 181 ELLALGGRYVPLDTLLADSDIVSLHCPLLPSTYHLIDSHALAKMKRGAMLINTGRGGLVE 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S A + ALK+ ++G LG+DVYE E +FFED SN +QDDV RL NV+ T HQAF Sbjct: 241 SNALVGALKSGQLGHLGLDVYEEEGGIFFEDHSNLPLQDDVLARLLMFPNVIVTAHQAFF 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+T I+QTTL N+ G T N + Sbjct: 301 TREAMTEIAQTTLGNVEAWRDG-TPRNVV 328 >UniRef50_Q4L766 D-3-phosphoglycerate dehydrogenase n=3 Tax=Staphylococcus RepID=Q4L766_STAHJ Length = 532 Score = 393 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 79/329 (24%), Positives = 156/329 (47%), Gaps = 17/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + LQ + F ++ L + E + + ++ V Sbjct: 1 MKHNILVSDPISTDGLQSLLNHSDFNVDIKTDLDEQSLLDIIGDYEGLIVRSQTQVTQQV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+ +K IA G +N+D+DAA G+ V+ P + + EH++ M++ + R I Sbjct: 61 IEKA--SNLKVIARAGVGVDNIDIDAATLQGILVINAPDGNTISATEHSVAMILAMARNI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+ ++ ++ + G +Y KT GVIG G+IG+ + + L+ FGM++LA+DPY + Sbjct: 119 PQAHASLKNKEWNRKAFKGVELYQKTLGVIGAGRIGIGVAQRLQSFGMKVLAYDPYLTED 178 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +LGV+ + + ++D +++H PLTP+ ++N F + K + I+N +RG +I+ Sbjct: 179 KAQQLGVKLATIDEIARQADFVTVHTPLTPKTRGIVNADFFSKAKPTLQIINVARGGIIN 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + AL N +I +DV+E+E L ++ T H Sbjct: 239 EDDLLNALNNNQIARAALDVFEHEPPT--------------DSPLIEHDKIIVTPHLGAS 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ + + + ++ + + + Sbjct: 285 TIEAQEKVAVSVSEEIIDILENGNVTHAV 313 >UniRef50_D1FX73 3-phosphoglycerate dehydrogenase-like protein n=1 Tax=Chironex fleckeri RepID=D1FX73_CHIFL Length = 520 Score = 393 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 80/325 (24%), Positives = 145/325 (44%), Gaps = 16/325 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + D + + + ES +++ + E+ + + + + V Sbjct: 9 VLISDKVD-EVCKTIFESNKINVDYRPGISKEELLAIIKDYDCLVVRSATKVTAEVFSAA 67 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K + G +N+DL AA G+ V+ P + + AEH MM +L R I + Y Sbjct: 68 P--NLKLVGRAGTGVDNIDLKAATNNGVFVMNTPGGNTMSAAEHTCAMMFSLARHIPQGY 125 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAAALE 183 ++ + G + GKT G+IG G+IG + ++ MR + +DP P AA E Sbjct: 126 MSMQEGKWERSKFMGCELKGKTLGIIGLGRIGKEVALRMQACEMRTVGYDPIVPKEAAAE 185 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 GVE+++L ++ D I++H PL P+ L+N F++ K + ++N +RG +ID Sbjct: 186 FGVEFMELEEMWPIVDFITVHTPLIPQTKGLVNAKTFDKCKKTIRVINVARGGIIDESDL 245 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 ++AL K G+DV+ +E V L V+ T H TAEA Sbjct: 246 LDALNAGKCAGAGLDVFSSEPPSG------------VVSELVKHPRVVCTPHLGASTAEA 293 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ + + + G+T + Sbjct: 294 QVRVAKEIAEQIVDACNGKTAVGLV 318 >UniRef50_Q4K893 D-lactate dehydrogenase n=15 Tax=Gammaproteobacteria RepID=Q4K893_PSEF5 Length = 329 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 166/328 (50%), Positives = 229/328 (69%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ ++S++ YD++ G EL+F L+ TA A E VC F+NDD S PV Sbjct: 1 MRTILFSSQNYDRESFLGAQLPAGIELQFQAARLSLDTAALAERHEVVCAFINDDLSAPV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L G + IALR AG+N+VDL AA+ LGL VVRVPAY P AVAEHA+ +++ LNRR+ Sbjct: 61 LEQLAAGGTRLIALRSAGYNHVDLSAAQRLGLDVVRVPAYSPHAVAEHAVALILALNRRL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTR+ +F+L GLTGF + GKT G++GTG+IG RI+ GFG +LLA+DP+P+ A Sbjct: 121 HRAYNRTREGDFTLHGLTGFDLVGKTVGIVGTGQIGATFARIMAGFGCQLLAYDPFPNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG Y+DLP L ++S +ISLHCPLT ++ +L+N+ + M+ G M++NT RG L+D+ Sbjct: 181 VEALGARYLDLPELLAQSQIISLHCPLTEDSRYLINQQSLAHMQPGAMLINTGRGGLVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEALK+ ++G LG+DVYE E LFFED+S+ +QDDV RL NV+ T HQAFLT Sbjct: 241 PALIEALKSGQLGYLGLDVYEEEAQLFFEDRSDLPLQDDVLARLLTFPNVIVTAHQAFLT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL +I++TTL N+++ G+ N + Sbjct: 301 REALAAIAETTLHNIASWAAGQ-PQNRV 327 >UniRef50_A5IMH3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=7 Tax=cellular organisms RepID=A5IMH3_THEP1 Length = 308 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 106/318 (33%), Positives = 166/318 (52%), Gaps = 19/318 (5%) Query: 1 MKLA---VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 MK+A V+ DK+ Q + E+ + L ++ K + + + + Sbjct: 1 MKMARYRVHVNDPLDKEATQLLMSKDELEVT-SEHLEKDELMKIIPEIDVLVVRSATKVT 59 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 ++E K +K IA G +N+D+ AKE G+K++ P +VAE A+G+M+ Sbjct: 60 ADIIEAGK--NLKIIARAGIGLDNIDVQKAKEKGIKILNTPGASAPSVAELAMGLMLACA 117 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R I RA ++ + + L G + GKT G+IG G IG + + FGM+++A+DP Sbjct: 118 RHIARATISLKEGKWEKKALNGKELLGKTLGLIGFGNIGQEVAKRALAFGMKIIAYDP-- 175 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + A +L VEYVDL TLF ESD ISLH PLT H++N + +MK+GV+IVNT+RG Sbjct: 176 AKPATDLPVEYVDLDTLFRESDFISLHVPLTESTRHIINRESIAKMKDGVIIVNTARGGT 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID +A EAL + K+ + G+DV+E E D++ R+L NV+ T H Sbjct: 236 IDEEALYEALVSGKVYAAGLDVFEVEPPT-----------DEIRRKLLNLDNVVATPHIG 284 Query: 298 FLTAEALTSISQTTLQNL 315 T EA + ++ + Sbjct: 285 ASTDEAQNRVGTELVEKI 302 >UniRef50_C4V410 Phosphoglycerate dehydrogenase n=4 Tax=Veillonellaceae RepID=C4V410_9FIRM Length = 565 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 81/328 (24%), Positives = 145/328 (44%), Gaps = 19/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 ++ + + + + + +E++ D + E+ +A+ + + VL Sbjct: 39 RMKILAADGISPEGIGLL---TDYEVDVRDKISHEELLDVIGDYDALMVRSASKVTADVL 95 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E K +K I G +N+D+ AA E G+ V+ P + A EH + MM+ + R I Sbjct: 96 ERAGK--LKIIGRAGVGVDNIDVKAATERGIIVINSPGGNTIAATEHTVAMMLAMARNIP 153 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 A ++ + G + GKT GVIG G+IG + + F M ++A+DPY + Sbjct: 154 TADATMHAGQWNRKAYVGVELRGKTLGVIGMGRIGGGVAKRALAFDMNVIAYDPYINEER 213 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A LGV L + ++D I++H PLT E +++ A +MK GV +VN +RG +I+ Sbjct: 214 AKALGVTVGTLDDIIEQADFITVHMPLTKETRGMISMAQMRRMKQGVRLVNCARGGIINE 273 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 EA++ + +DV+E+E L + ++ T H T Sbjct: 274 HDLAEAVREGIVAGAAIDVFESEPLAE-------------DSPLRSVPGIVLTPHLGAST 320 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +S + + +GE + Sbjct: 321 VEAQIGVSVDVAKGICAALRGEPVLAAV 348 >UniRef50_B0TAQ8 D-3-phosphoglycerate dehydrogenase n=4 Tax=Clostridia RepID=B0TAQ8_HELMI Length = 526 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 87/327 (26%), Positives = 153/327 (46%), Gaps = 17/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V +K + + + ++ L ++ + +AV + ++ ++E Sbjct: 1 MRVLVCDPISQKGIDVLTSAGDVAVDVKLKLTEDQIVEIIAEYDAVVVRSETKITKRIIE 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 + +K I G +N+D++AA G+ VV P + A AE + ++ + R + Sbjct: 61 AADR--LKAIGRAGVGVDNIDVEAATRKGIVVVNAPEGNTIAAAELTVAHILAIARNVGS 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAA 181 A + + TG + GKT G++G GKIG + + + F M ++A+DPY S A Sbjct: 119 ANLSLKGGKWDRSKYTGIELKGKTLGILGLGKIGSEVAKRARAFDMTVIAYDPYASVEKA 178 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LGV DL T+F +SD I++H P T + Y +++ A F MK GV IVN +RG +ID Q Sbjct: 179 KSLGVTVTDLETVFRQSDFITVHMPKTKDTYRMISAAQFAIMKEGVRIVNCARGGIIDEQ 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A+++ K+ + G+DV+E E L A V T H T Sbjct: 239 ALYDAIQSGKVAAAGLDVFEKEPCT--------------DSPLFALDQVTATPHLGASTK 284 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ ++ + +GE + Sbjct: 285 EAQVNVAIDVAYDILRVLRGEAVSAAV 311 >UniRef50_A6UQN3 D-3-phosphoglycerate dehydrogenase n=4 Tax=Euryarchaeota RepID=A6UQN3_METVS Length = 523 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 160/327 (48%), Gaps = 19/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 L + T + ++ + E+ E+E + E+ + +A+ + ++ +++ Sbjct: 2 LKILITDPLHESAIEILKEAG--EVEIATGISIEEIKQKIKDADALVVRSGTTVTKEIID 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K IA G +NVDLDAA E G+ VV P +VAE G+M++ R I + Sbjct: 60 A--SENLKVIARAGVGVDNVDLDAATEKGVVVVNAPDASSISVAELMFGLMLSAARNIPQ 117 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAA 181 A + + + G +Y KT G++G G+IG + + + F M ++A+DPY P A Sbjct: 118 ATASLKKGEWDRKSFKGMEVYAKTLGIVGLGRIGQQVAKRAQAFEMNIVAYDPYIPENVA 177 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 ELG++ + + L +ES+ I+LH PLT + H++ + F+ MKN +I+N +RG LID Sbjct: 178 SELGIKLLSVDELCAESEFITLHVPLTTKTKHMIGKTQFDLMKNNTIIINCARGGLIDEN 237 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A+ K+ + G+DV+E E L + + ++ T HQ T Sbjct: 238 ALYDAINCGKVKAAGLDVFEEEPPTK--------------NPLISLNGLIGTPHQGASTE 283 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA S + + KGE+ N + Sbjct: 284 EAQLSAGTIVAEQTVKILKGESAENVV 310 >UniRef50_P73821 D-3-phosphoglycerate dehydrogenase n=40 Tax=Cyanobacteria RepID=SERA_SYNY3 Length = 554 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 154/326 (47%), Gaps = 19/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D+ + + + +++ L + +A+ + + +++ Sbjct: 31 KVLVSDSIDQVGIDILKQVAQVDVKT--GLSEAEIIDIVPEYDAIMLRSATKVTEKIIQA 88 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K I G +N+D+ AA G+ VV P + A AEHA+ MMM L R I A Sbjct: 89 G--SQLKIIGRAGVGVDNIDVPAATRQGIVVVNSPEGNTIAAAEHALAMMMALARHIPDA 146 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 + +++ + + G +Y KT GV+G GKIG + + K GM+LLA+DP+ S A Sbjct: 147 NKSVKESKWERKQFIGTEVYKKTLGVVGLGKIGSHVAGVAKAMGMKLLAYDPFISQERAD 206 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ++G VDL LFSE+D I+LH P TPE +L+N +MK I+N SRG +ID +A Sbjct: 207 QIGCTLVDLDLLFSEADFITLHIPKTPETANLINAETLAKMKPTARIINCSRGGIIDEEA 266 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + A++ +IG +DV+ E RL NV+ T H T E Sbjct: 267 LVTAIETAQIGGAALDVFAQEPLG--------------ESRLREFSNVILTPHLGASTEE 312 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A +++ + + ++ G + + Sbjct: 313 AQVNVAVDVAEQIRDVLLGLPARSAV 338 >UniRef50_A5FRL7 D-3-phosphoglycerate dehydrogenase n=5 Tax=Dehalococcoides RepID=A5FRL7_DEHSB Length = 526 Score = 392 bits (1009), Expect = e-108, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 145/329 (44%), Gaps = 20/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK V + L + E +++ L E+ +A+ + + + Sbjct: 1 MK-KVLVSDALSATGLAPLKEIAQVDVKT--GLKPEELISIIGEYDALLVRSQTQVTADI 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + KK ++ I G +N+DL AA G+ VV P + + EH + +M+ + R I Sbjct: 58 INAGKK--LQVIGRAGVGVDNIDLKAATGNGIIVVNAPTGNTISATEHTLALMLAMARHI 115 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-A 179 RA + + G + GKT G++G G IG + + MR++ +DP+ S Sbjct: 116 PRANASLKSGQWKRNEFVGSELKGKTLGIVGLGNIGSEIAKRALALEMRVIGYDPFISME 175 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +L VE + L ++D I+LH P+T + L+ E MK V ++NTSRG +ID Sbjct: 176 RAKKLQVELLPFEDLLKQADFITLHVPMTGQTKGLIGPKELEMMKPTVRLINTSRGGIID 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A +A+K ++IG +DV+ E L C N++ T H Sbjct: 236 EEALAKAVKEKRIGGAAIDVFSKEPCT--------------ESCLFECDNIIVTPHLGAS 281 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA + ++ + ++ +G + Sbjct: 282 TAEAQELATSDVVKQVIDVFEGRPARYAV 310 >UniRef50_B8CX87 D-3-phosphoglycerate dehydrogenase n=1 Tax=Halothermothrix orenii H 168 RepID=B8CX87_HALOH Length = 527 Score = 392 bits (1008), Expect = e-108, Method: Composition-based stats. Identities = 85/327 (25%), Positives = 149/327 (45%), Gaps = 19/327 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + K ++ + + + F L E+ + + + + + L++ Sbjct: 3 KVLVSDNISPKGIEILEQEAD--VTFNPDLSREEFLDIIGEYDGLIVRSMTEVDKEALDK 60 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K I G++N+D++ A + G+ V P + + EH IGMM+ L+R I +A Sbjct: 61 A--RNLKVIGRAGTGYDNIDIEEASKRGIIVFNTPTGNTISAVEHTIGMMLALSRNIPQA 118 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 Q + + + G + GKT G+IG G+IG + + FGM+++A DPY P A Sbjct: 119 NQALHEGIWDRKKYMGVEVKGKTLGIIGLGRIGSRVAVRAQAFGMKVIANDPYLPPEKAA 178 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 ++ V + + +SD I+LH PLT E YH+L+ F MK+ V I+N +RG +D+QA Sbjct: 179 KINVPLLGFKEVLKKSDYITLHTPLTDETYHILSHKEFAIMKDNVRIINCARGKNVDTQA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC-HNVLFTGHQAFLTA 301 +AL K+ +DV+E E L V+ T H T Sbjct: 239 LAKALAEHKVAGAAIDVHEVEPL-------------PEDNPLLKYQDRVIMTCHLGGTTT 285 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA+ ++S + + ++ + L Sbjct: 286 EAMDNVSIAAAEQVLDVLNNGLPESPL 312 >UniRef50_Q49YF7 D-3-phosphoglycerate dehydrogenase n=55 Tax=Bacillales RepID=Q49YF7_STAS1 Length = 538 Score = 391 bits (1007), Expect = e-107, Method: Composition-based stats. Identities = 84/326 (25%), Positives = 156/326 (47%), Gaps = 17/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 + + + L+ + + FE+ L + +A+ + + ++E Sbjct: 3 KILVSDPISPEGLKSLIDHNDFEVVIDTELDEAELINQIADYQALIVRSQTQVTEAIIEA 62 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K IA G +N+D+DAA + G+ V+ P + + EH++ M++++ R I +A Sbjct: 63 AP--NLKVIARAGVGVDNIDVDAATKHGVIVINAPDGNTISATEHSMAMILSMARNIPQA 120 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-AL 182 +Q +D + + G +Y KT GVIG G+IG+ + + + FGM +LAFDPY S A Sbjct: 121 HQSLKDGKWDRKTYRGTELYNKTLGVIGAGRIGLGVAKRAQSFGMHILAFDPYLSEDKAK 180 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 EL V + + +SD +++H PLTP+ ++ +A FE+ K + I+N +RG +ID A Sbjct: 181 ELNVTRATVEEIAEQSDFVTVHTPLTPKTKGIVGKAFFEKAKPNLQIINVARGGIIDEAA 240 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 ++AL +I S +DV+E+E L ++ T H T E Sbjct: 241 LVDALNQNQIQSAAIDVFESEPAT--------------ESPLVNHEKIIVTPHLGASTVE 286 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + + ++ + N + Sbjct: 287 AQEKVAVSVANEIVDIFENGNVFNAI 312 >UniRef50_A8ZXY9 D-3-phosphoglycerate dehydrogenase n=6 Tax=Deltaproteobacteria RepID=A8ZXY9_DESOH Length = 532 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 93/329 (28%), Positives = 150/329 (45%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V + D + ++ GF ++ L E+ +A+ I + + Sbjct: 1 MTMKVLVSDTIDASGVSRLENESGFAVDVKTGLPPEELKSIIGQYDALIIRSATKVTADI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE +K +A G +NVD+ AA + G+ V+ P + AEH I MMM L R I Sbjct: 61 LEAG-APKLKAVARAGIGLDNVDIPAATKHGVAVMNTPEGNVVTTAEHTIAMMMALTRNI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + R + + L G ++ KT GVIG GKIG + + M ++ FDP + Sbjct: 120 PQGTLSLRSGQWEKKKLQGREVFNKTLGVIGFGKIGSIVADRARQLKMNVIVFDPNIART 179 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +E G EYV L LF+ +D I++H P + LLN+AAFE+MK GVM++N +RG ++D Sbjct: 180 TIENEGFEYVSLDDLFARADYITVHVPKLKQTVGLLNKAAFEKMKTGVMVLNCARGGIVD 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +AL + ++ + +DV+ E L NV+ T H Sbjct: 240 EADLYDALMSGRVAAAALDVFVTEPPG--------------EHPLLKLDNVIATPHLGAS 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++++ + K T N + Sbjct: 286 TKEAQVNVAEAAAHQIIEFLKNNTVINAV 314 >UniRef50_O43175 D-3-phosphoglycerate dehydrogenase n=53 Tax=Bilateria RepID=SERA_HUMAN Length = 533 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 82/326 (25%), Positives = 145/326 (44%), Gaps = 18/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D +++ + G ++ L E+ CE + + + V+ Sbjct: 8 KVLISDSLD-PCCRKILQDGGLQVVEKQNLSKEELIAELQDCEGLIVRSATKVTADVINA 66 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K ++ + G +NVDL+AA G+ V+ P + + AE GM+M L R+I +A Sbjct: 67 AEK--LQVVGRAGTGVDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLARQIPQA 124 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE 183 +D + + G + GKT G++G G+IG + ++ FGM+ + +DP S Sbjct: 125 TASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVATRMQSFGMKTIGYDPIISPEVSA 184 Query: 184 -LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 GV+ + L ++ D I++H PL P LLN+ F Q K GV +VN +RG ++D A Sbjct: 185 SFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGA 244 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + AL++ + +DV+ E R L NV+ H T E Sbjct: 245 LLRALQSGQCAGAALDVFTEEPPR--------------DRALVDHENVISCPHLGASTKE 290 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A + + ++ KG++ + Sbjct: 291 AQSRCGEEIAVQFVDMVKGKSLTGVV 316 >UniRef50_D0MG73 Glyoxylate reductase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MG73_RHOM4 Length = 322 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 97/336 (28%), Positives = 164/336 (48%), Gaps = 28/336 (8%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDF-----LLTEKTAKTANGCEAVCIFVNDDGSRP 59 + T+ ++ L+ + E G ++E D L + + A +A+ +D + Sbjct: 4 IVVTRPVMEEGLRPLFE-NGHQVEILDPDPEHPLDEDALIEAAREADALITMPSDPVTAR 62 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VLE K ++ +A G+ N+DL+AA+ G+ V P +A A+ +++ L RR Sbjct: 63 VLENCPK--LRIVAQHAVGYENIDLEAARARGIVVTHTPGVLTDATADFTFALLLALVRR 120 Query: 120 IHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 + A + R+ +F L G + K G++G G+IG A+ R GFGMR++ ++ Sbjct: 121 VREADRYVREGHFKRWETKLLLGHDLRDKVLGIVGLGRIGSAVARRALGFGMRVVYYNRR 180 Query: 177 PSAAALELG--VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 P+ +E YV L SDVIS+HCPL E+YHL + AAF +MK ++VNT+R Sbjct: 181 PANPTIERQSCARYVSFDELLRTSDVISIHCPLNKESYHLFDRAAFAKMKPTAVLVNTAR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D +A +EAL+ +I +DV+E+E + L V+ Sbjct: 241 GPIVDEEALVEALEQGQIAGAALDVFEHEPRVHP--------------ALLRSDRVVLAP 286 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKG-ETCPNELV 329 H T EA T++++ + + + G E P LV Sbjct: 287 HLGSATVEARTAMARACAEAVLAVLNGEEKIPYRLV 322 >UniRef50_B5YAK7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YAK7_DICT6 Length = 316 Score = 390 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 97/334 (29%), Positives = 165/334 (49%), Gaps = 25/334 (7%) Query: 1 MKLAVYSTKQYDK--KYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDD 55 M + + + ++K ++V + G E+ F L E+ + + + + + D Sbjct: 1 MFKVLITPRSFEKIKDKFEEVFKEEGIEVMLNPFGRVLTEEEMRELIRDVDGLIVGI-DP 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 + VL+ + +K I+ G +N+D+ AK+ + V P + AVAE +G+++ Sbjct: 60 VTSKVLKNA--NKLKVISKYGVGVDNIDILEAKKRNIVVTNTPGANSNAVAELTVGLIIN 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + R+I+ + ++TR+ + G + KT GVIGTG IG ++ +LKGF +R+L FD Sbjct: 118 VLRKINLSDKKTREGRWDR--FIGNELSEKTLGVIGTGSIGRRVIELLKGFNLRVLCFDK 175 Query: 176 YPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 YP A + V YV L L SDV+S+H PLT E YH+++E MK +++NTSR Sbjct: 176 YPDYEWASKEKVFYVTLDELLRSSDVVSIHVPLTEETYHMISEKELRMMKKNAVLINTSR 235 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D A LK +I G+DV+E E L NV+ T Sbjct: 236 GGIVDEDALYRFLKEGRISGAGLDVFEKEPPQ--------------NSPLLQLDNVVVTS 281 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T EA+ ++++ ++NL KG + + Sbjct: 282 HIGAHTEEAVANMAKLAVENLLLALKGREPLSRV 315 >UniRef50_C1TPS0 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TPS0_9BACT Length = 318 Score = 390 bits (1004), Expect = e-107, Method: Composition-based stats. Identities = 87/333 (26%), Positives = 151/333 (45%), Gaps = 21/333 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTA-KTANGCEAVCIFVNDDGSRP 59 M VY + + L +N + D + K + + V + + Sbjct: 1 MN-KVYVCHKIPEAGLNLLNGKVEYRCWDGDGPVPRDLLLKEISDVDGVITMLTEKVDSE 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + VK ++ G+NNVD++ A G+K+ P EA A+ A G+++ +RR Sbjct: 60 FFDNAP--NVKVVSNYAVGYNNVDVEEATSRGVKITNTPGVLTEATADIAFGLLVAASRR 117 Query: 120 IHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 A + R ++ L G ++GKT G+IG G+IG A+ R GFGM+++ P Sbjct: 118 FTEAERYLRSGKWTCWHPTMLLGREIFGKTLGLIGFGRIGKAVARRASGFGMKVIYHTPS 177 Query: 177 PSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A + G +V + +SD +SLHCPL L+ + E+MK ++VNTSRG Sbjct: 178 GGPATDQGDGPRWVSFEEILEKSDYLSLHCPLNDRTRGLIGKKELERMKPDAVLVNTSRG 237 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D + E+L++ IG+ G+DVY+ E + L + NV+ H Sbjct: 238 PVVDQTSLYESLRDGVIGAAGLDVYDEEPISLED-------------PLLSLENVVMLPH 284 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ N+ ++ +G+ N + Sbjct: 285 IGSATREARDAMATMAASNMLDVLEGKEPRNPV 317 >UniRef50_Q67TJ9 Phosphoglycerate dehydrogenase n=1 Tax=Symbiobacterium thermophilum RepID=Q67TJ9_SYMTH Length = 540 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 92/331 (27%), Positives = 153/331 (46%), Gaps = 24/331 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T+ + + + + ++ + +E+ + +A+ + V Sbjct: 1 MKILV--TEAISETGISLLRDEHEVDVR---KVTSEELLEIIPEYDALITRSETKVTAEV 55 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L + +K + G +N+D+ AA E G+ VV VP + + AEHA G+++ + R I Sbjct: 56 LARGTR--LKVVGRAGVGVDNIDVAAATERGVVVVNVPGANTYSTAEHAFGLLIAVARNI 113 Query: 121 HRAYQRT-RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PS 178 +A+ R+ + G ++GKT G+IG G+IG + + FGMR+LA+DPY P Sbjct: 114 PQAHHALAREGRWDRMSFVGTELHGKTLGIIGLGRIGSEVAVRARAFGMRVLAYDPYVPH 173 Query: 179 AAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + A LGV V L L E D +++H TPE+ L+ A MK IVN +RG + Sbjct: 174 SRAEHLGVTLVPSLRGLLPEVDFLTIHAAKTPESARLIGAAELALMKPTARIVNCARGGM 233 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D +A ALK ++ +DV+ E L NV+ T H + Sbjct: 234 VDEEALYRALKEGRLAGAALDVFAAEPCT--------------DSPLFGLPNVVVTPHLS 279 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA + + Q + +GE P + Sbjct: 280 ASTAEAQDANGRYIAQYVLRALRGELVPEAV 310 >UniRef50_A7HDB1 D-3-phosphoglycerate dehydrogenase n=3 Tax=Proteobacteria RepID=A7HDB1_ANADF Length = 528 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 91/329 (27%), Positives = 160/329 (48%), Gaps = 17/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V + + ++ + E G E++ L ++ + + + + + + Sbjct: 1 MVARVLVSDDLSPEAVRILQE-AGLEVDVKVGLKPDQLERIVGDYDGLAVRSATKVTAQL 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++ + +K I G +NVDL AA G+ V+ P VAE A+ M++ L+R + Sbjct: 60 LDKAAR--LKVIGRAGVGVDNVDLAAATRRGVVVMNTPGGSSITVAELALSMILALSRHV 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A + + + G + G+T GV+G G IG ++ GMR++AFDP+ SA Sbjct: 118 AAATGSVKAGKWEKKRFQGHELAGRTLGVVGIGNIGSVLVARAVALGMRVVAFDPFISAE 177 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +LG VDL TL+ E+DV+S+H PLT + HL++ A +MK G ++VN +RG ++D Sbjct: 178 AAAKLGASLVDLDTLWREADVVSIHVPLTDKTRHLVDATALGKMKKGALLVNCARGGIVD 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A +AL++ ++G G+DV+E E L NV+ T H Sbjct: 238 ERALADALRSGQLGGAGLDVFEQEPP-------------PADHPLYGLENVILTPHIGAS 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++++ + L++ N + Sbjct: 285 TEEAQSAVAVAVAEQLADYLVRGVVRNAV 313 >UniRef50_A9WCW3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A9WCW3_CHLAA Length = 525 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 145/325 (44%), Gaps = 18/325 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + T++ + L + ++ ++ L +A+ + + V+ Sbjct: 4 ILVTEKIAAEGLAVLRQAGTVDVRL--DLDKPTLISIIGEYDALVVRSATKVTAEVIAAG 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ ++ I G +N+D++AA G+ VV PA + AVAE IG++++L RRI +A+ Sbjct: 62 ER--LRVIGRAGTGVDNIDVEAATRRGIIVVNAPASNNVAVAELTIGLLISLARRIPQAH 119 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALE 183 + ++ G+ + GKT G++G G+IG + R + M +LA+DP S A + Sbjct: 120 ASLQSGRWARNDFVGWEVRGKTLGLVGLGRIGSEVARRARSLEMEVLAYDPVVSFDRAEQ 179 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LGV V L L SDVISLH PL +L ++ QMK G ++N SRG ++D A Sbjct: 180 LGVSLVTLDELVQRSDVISLHVPLIESTRNLFDQQRIMQMKRGAYLINASRGGIVDEVAL 239 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +EAL + +G +DVY E L ++ H T EA Sbjct: 240 VEALNSGHLGGAALDVYNQEPL-------------PADSPLLGHPKIITVPHIGASTTEA 286 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 S + + G T + Sbjct: 287 QLSAGTEMAEGVVTALNGGTPRYAV 311 >UniRef50_B5EQZ7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=3 Tax=Bacteria RepID=B5EQZ7_ACIF5 Length = 331 Score = 389 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 160/328 (48%), Positives = 218/328 (66%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ V S + YD+++L EL F + L+ TA A G A+C FV+D Sbjct: 1 MRCLVTSARPYDEQFLSA-ANHGRHELVFVETALSADTAFIAQGYPAICPFVDDTLDAKT 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE + + G K + LR GFN+VD+ AA++ G+ V+RV Y P AVAE+A+G+M+TLNR + Sbjct: 60 LETIARLGTKLLVLRSTGFNHVDMPAAEKYGITVMRVRDYSPYAVAEYAVGLMLTLNRHL 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R RD NF L+GL GF M+GKT G+IGTGKIG A+ RIL G G LL +D + A Sbjct: 120 HKAYNRVRDGNFLLDGLLGFDMHGKTVGIIGTGKIGQALARILHGMGCHLLGYDTVANPA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LELGV YV L L +S ++SLH PL PE HL+N F M +G M++NTSRG LID+ Sbjct: 180 CLELGVAYVPLEELLVKSQIVSLHVPLLPETRHLMNAERFALMPDGAMLINTSRGPLIDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I ALK++ +G++G+DVYE E +L+F+D +D+I DD F RL NV+ TGHQAF T Sbjct: 240 TALIAALKSRHLGAVGLDVYEEEAELYFKDHCDDIICDDSFERLLTFPNVIITGHQAFFT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +EALT+I++TT+QNL + G+ PN + Sbjct: 300 SEALTTIARTTIQNLDDYSDGKDNPNCV 327 >UniRef50_A6C9V4 Phosphoglycerate dehydrogenase n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C9V4_9PLAN Length = 541 Score = 389 bits (1000), Expect = e-107, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 148/326 (45%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T L+ + ++ E++ L E+ + + + I + VL+ Sbjct: 4 VLITDNLSPAGLKILEDNPEIEVDIRSGLSPEEVREALKSADGIIIRSATKLTEEVLK-- 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K I G +N+D AA G+ V+ PA + + AE I +MM L R I AY Sbjct: 62 GQPRLKAIVRAGVGVDNIDRAAATREGIVVMNTPAGNTTSTAEQTIALMMALARNIGPAY 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 ++ + + LTG + GKT +IG G+IG+++ +G M+++ +DP+ SA A E Sbjct: 122 ATMKEGKWERKKLTGTQVAGKTLAIIGLGRIGLSVAHRAQGLEMKVIGYDPFMSAERAAE 181 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 G+E Y ++ L D +++H PLT E L+N M+ GV I+N +RG +++ Sbjct: 182 YGIELYKEVDELVKHCDFLTVHTPLTDETRDLINAERIATMRPGVRIINCARGGIVNEDD 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +AL++ K+ DV+ E RRL N+L T H T E Sbjct: 242 LADALESGKVAGAACDVFTQEPPE--------------NRRLIDAPNMLATPHLGASTDE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + +S+ + + Sbjct: 288 AQEMVALEAAEIISDFLTKNEIRHAI 313 >UniRef50_B1HVJ4 Phosphoglycerate dehydrogenase n=5 Tax=Bacillales RepID=B1HVJ4_LYSSC Length = 535 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 86/329 (26%), Positives = 148/329 (44%), Gaps = 19/329 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFE--LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 + V+ + + + + + + L E+ + + + +R V Sbjct: 8 INVFIADPLSEDGIFPLRQEQDLDLNIIVDTGLAPEELMTKIADVDVLLVRSQTTVTREV 67 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +K I G +N+DL AA E G+ VV P + + AEH I MM +L R I Sbjct: 68 IEAAK--SLKLIGRAGVGVDNIDLTAATEHGIIVVNAPDGNTNSAAEHTIAMMTSLARHI 125 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+ ++ + + G + KT GV+G G+IGV + KG M ++A+DP+ + Sbjct: 126 PQAFNTLKNGKWDRKSYVGVELKNKTLGVVGFGRIGVEVAYRAKGQRMNVMAYDPFLTDE 185 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A ELGV + + +D I++H PL PE +L+N+ F MK+GV I+N +RG +I+ Sbjct: 186 RAKELGVTKASVEEICEAADFITVHTPLLPETRNLINKEKFAMMKDGVRIINCARGGIIN 245 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A+ K+ +DV+ +E +L V+ T H Sbjct: 246 EDDLYDAIVAGKVAGAALDVFVSEPAT--------------DHKLLTLPQVIATPHLGAS 291 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S++ ++ K T N + Sbjct: 292 TIEAQESVAVDVSNDIIKFYKTGTVTNPV 320 >UniRef50_A7FYM9 D-lactate dehydrogenase n=10 Tax=Clostridium RepID=A7FYM9_CLOB1 Length = 336 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 129/325 (39%), Positives = 197/325 (60%), Gaps = 2/325 (0%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK 65 Y + + ++ +E +G ++ A A G + + I ND +R LE++K Sbjct: 11 YCVRPDEVDSFKKFSEKYGHTVDLIPDSFGPNVAHLAKGYDGISILGNDTCNREALEKIK 70 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 G+KY+A R AG NN+D DAAKE G+ V VPAY P +V+E IG+ ++L R+I A + Sbjct: 71 DCGIKYLATRTAGVNNIDFDAAKEFGINVANVPAYSPNSVSEFTIGLALSLTRKIPFALK 130 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR-LLAFDPYPSAAALEL 184 R NF+L GL G + T GVIGTG+IG+ ++ GFGM+ ++ +D + + A + Sbjct: 131 RVELNNFALGGLIGVELRNLTLGVIGTGRIGLKVIEGFSGFGMKKMIGYDIFENEEAKKY 190 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 +EY L +F E+D+I+LH PLT +NYH++ + + +MK+GV I+N +RGALIDS+A I Sbjct: 191 -IEYKSLDEVFKEADIITLHAPLTDDNYHMIGKESIAKMKDGVFIINAARGALIDSEALI 249 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 E LK+ KI +D YE E+ +F +K N+++QDD RL + NV+ T H F T EA+ Sbjct: 250 EGLKSGKIAGAALDSYEYEQGVFHNNKMNEIMQDDTLERLKSFPNVVITPHLGFYTDEAV 309 Query: 305 TSISQTTLQNLSNLEKGETCPNELV 329 +++ + TL NL E TC N+ V Sbjct: 310 SNMVEITLMNLQEFELKGTCKNQRV 334 >UniRef50_D2LI76 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LI76_RHOVA Length = 347 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 170/330 (51%), Positives = 226/330 (68%), Gaps = 1/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A +S + +L + N +G EL FF L+ +TA+ A G AVC FV D Sbjct: 1 MRIAFFSEHAFQTPFLIEANREYGHELVFFKEQLSRRTAQLAAGFVAVCPFVTDKLDAET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L G K IALR AGFNN+DL AA+ LGL V+RVPAY P A+AEHA+ +M+ LNRRI Sbjct: 61 LRILADGGTKLIALRSAGFNNLDLAAAERLGLCVMRVPAYAPTAIAEHAVALMLALNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + AY R R+ NFSL+ L GF M G+T G++GTGKIG ++ RI+ GFG +L +D Y + A Sbjct: 121 NHAYNRVREGNFSLDHLVGFNMEGRTVGIVGTGKIGESLARIMHGFGCHILGYDIYQNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + LG++YVDLPTL SESD++SLHCPLTPE HL+NE + MK G M++NT+RG L+++ Sbjct: 181 CIALGMKYVDLPTLLSESDIVSLHCPLTPETKHLINEETLKLMKPGSMLINTARGGLVNA 240 Query: 241 QAAIEALKNQK-IGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A IEALK + + +GMDVYE E LFF D S+ +IQDDVF L+ NV+ TGHQAFL Sbjct: 241 EAVIEALKRKDGLAYVGMDVYEREEGLFFSDHSSSIIQDDVFELLTTMRNVIVTGHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EAL I+ TTL N+++ E G P ++ Sbjct: 301 TREALAEIAHTTLGNVADYELGTPNPKNVL 330 >UniRef50_Q2RH37 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Bacteria RepID=Q2RH37_MOOTA Length = 329 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 105/332 (31%), Positives = 157/332 (47%), Gaps = 21/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDF-LLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K VY T+ + L + E E+ D L + + G + + + D V Sbjct: 3 KWNVYVTRLVPQPALDLLAEYCDLEINPEDRVLTRAELLEKVRGRDGILCLLTDILDDEV 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 K K A GFNNVDL+AA G+ + P EA A+ A ++ + RR+ Sbjct: 63 FTAAKGA--KIFANLAVGFNNVDLEAATRHGIMITNTPGVLTEATADMAWALLFAVARRV 120 Query: 121 HRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + TR + G + G + GKT GVIG G+IG A R +GF M++L D P Sbjct: 121 VEGDKFTRAGKYKGWGPLLMLGQEITGKTLGVIGAGRIGTAFARKARGFDMKVLYHDVQP 180 Query: 178 SAAALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 S A E G ++VD TL E+D +SLH PL P HL++ + MK +++NTSRG Sbjct: 181 SKAFEEATGGQFVDKETLLKEADFVSLHVPLMPSTTHLISTPELKLMKKTAILINTSRGP 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D +A ++AL+ ++I G+DV+ENE +L L+ NV+ H Sbjct: 241 VVDEKALVKALREKEIWGAGLDVFENEPELAPG--------------LADLENVVLCPHI 286 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 A T E T+++ NL +GE P L Sbjct: 287 ASATWETRTNMALMAANNLLAALRGELPPQCL 318 >UniRef50_B0K2Z0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Thermoanaerobacter RepID=B0K2Z0_THEPX Length = 324 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 88/329 (26%), Positives = 153/329 (46%), Gaps = 21/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK V +++ + + + FE+ + +A+ + +R V Sbjct: 1 MK-KVLLSEEIHPEGRKLL--EGKFEIVTAPDTSQQTLISMVKDVDAIILRTRSKITREV 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E +K I+ AG +N+D++AA E G+ V +PA + +VAEH I M++ L++++ Sbjct: 58 IENAPH--LKIISRTGAGVDNIDVNAATEKGILVCNLPAVNNLSVAEHTIAMILNLSKQL 115 Query: 121 HRAYQRTRDANF-SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 + R N+ + + GK G++G G IG + + G GM+++A+DPY Sbjct: 116 SLMDKAVRSGNWGARNSNISVEIEGKVLGIVGMGNIGSLVAKKCHDGLGMKIVAYDPYVK 175 Query: 179 AAALELGVEYVDL-PTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 ++VD LF ESD ++LHCP PE ++ MK+ ++N +RG + Sbjct: 176 EKFRGYDYKFVDTREELFKESDFVTLHCPDIPETRGMITRELIYSMKHTAYLINAARGTV 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID QA IEALK ++I G+DV++ E L NV+ + H A Sbjct: 236 IDEQALIEALKEKRIAGAGLDVFQQEPPSS-------------DNELLRLENVILSPHSA 282 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPN 326 LT EA ++ +Q + + +G Sbjct: 283 ALTKEATVRMAVEAVQAVIDYFEGRQPKY 311 >UniRef50_B3DVF6 Phosphoglycerate dehydrogenase and ACT domains n=2 Tax=Verrucomicrobia RepID=B3DVF6_METI4 Length = 531 Score = 387 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 90/326 (27%), Positives = 147/326 (45%), Gaps = 17/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + KK + ++ S ++ L ++ A+ + V + +R V+E Sbjct: 7 ILIADPISKKGIAELQASAQLIVDEKYGLKEDELARVIADYDGVIVRSQTKITRKVIEAG 66 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 KK +K I G +NVD+DAA E G+ V+ P + A AEH +++ L R + +A+ Sbjct: 67 KK--LKVIGRAGVGIDNVDVDAATEKGIVVMNTPGGNTIATAEHTFSLLLALARNVAQAH 124 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALE 183 + + + G +YGK G+IG G++G+ + + FGM++ FDPY S Sbjct: 125 ASMQLGEWKRKNFEGIELYGKILGIIGLGRVGMEVAKRALAFGMKVKCFDPYLSPTKVKN 184 Query: 184 LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 L VE V L LF + D +SLH PLT E ++N+ ++ K G+ I+N +RG LI Sbjct: 185 LQVELVNSLDELFQDIDFLSLHVPLTQETEGIINKDNLKKCKRGIRIINCARGGLIRIAD 244 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 E LK+ + +DVYE E L NV+ T H A T E Sbjct: 245 LEELLKSGWVAGAALDVYEPEPP-------------PADFPLRGLPNVVLTPHLAASTIE 291 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + ++ N + Sbjct: 292 AQENVGTEIAAMVIDVLCHNIIRNAV 317 >UniRef50_B5JEX5 D-3-phosphoglycerate dehydrogenase n=2 Tax=Verrucomicrobiales RepID=B5JEX5_9BACT Length = 545 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 93/332 (28%), Positives = 157/332 (47%), Gaps = 20/332 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK---TAKTANGCEAVCIFVNDDGS 57 MK+ V + + + + GFE+ E + A G A+ + + + Sbjct: 14 MKILV--ADKISSTGVDFLKQQEGFEVVEAYGTFKEDYSKFLELAKGAAAIIVRSDSKVT 71 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R V E +K + G +N+D +AA + G+ V+ P + A AE M+ Sbjct: 72 REVFEVA-APTLKAVGRAGVGVDNIDSEAATDFGVVVMNTPGGNTIATAELTFTHMLCGA 130 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R + +A Q R+ + + G ++ KT GV G G+IG + + K FGM++LA+DPY Sbjct: 131 RPVPQAAQSMREGRWDRKIYGGSELFKKTLGVCGMGRIGAEVAKRAKAFGMKVLAYDPYL 190 Query: 178 SAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 S A E +GVE V+L LF ESD I++H PLT ++++AA MK+GV + N +RG Sbjct: 191 SGAKAETMGVEQVELDELFRESDYITVHMPLTDATRGMIDDAAIATMKDGVRLFNCARGG 250 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID A + L++ K+ + G+DVY +E + + T H Sbjct: 251 IIDEDALLRGLESGKVAAAGLDVYTSEPPAEDHPFRSQKTLN-------------LTPHL 297 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S+ ++++++ +G N + Sbjct: 298 GASTEEAQESVGLEIAESVTSVLRGGGIRNAI 329 >UniRef50_Q5WGX7 D-3-phosphoglycerate dehydrogenase n=8 Tax=Bacillaceae RepID=Q5WGX7_BACSK Length = 533 Score = 386 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 84/325 (25%), Positives = 144/325 (44%), Gaps = 21/325 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + ++ L + E+ E+ A +A+ I + +L + Sbjct: 14 ILVADTMSEEGLLPLLEADHVEVTQASV----DNAGPLEQYDALLIRSATTVTEELLSRM 69 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K +A G +NVD+ AA + G+ V+ P + + AEH MM L R I +A Sbjct: 70 PR--LKIVARAGVGVDNVDIQAATKHGVVVINAPDGNTISTAEHTFAMMCALLRNIPQAN 127 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + + + G + GKT G++G G+IG + + K F M +L +DP+ +A A + Sbjct: 128 ASVKSGKWDRKAYQGTELRGKTLGIVGFGRIGTQLAKRAKAFEMGVLVYDPFLTAERAEK 187 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LG+ +L + S +D+I++H PLT + LLN + K GV ++N +RG +ID QA Sbjct: 188 LGIAQGELDHVLSVADIITVHTPLTKDTKGLLNMETIAKTKPGVFLINCARGGIIDEQAL 247 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 L N + +DV+ E + L +V+ T H A T EA Sbjct: 248 KHYLNNGHVAGAALDVFTEEPAT--------------DKELIGHPSVVATPHIAASTKEA 293 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ Q + GE N + Sbjct: 294 QLNVAAQVSQEVLQFLNGEPALNSI 318 >UniRef50_B6HIS7 Pc21g23650 protein n=11 Tax=cellular organisms RepID=B6HIS7_PENCW Length = 347 Score = 385 bits (991), Expect = e-105, Method: Composition-based stats. Identities = 170/332 (51%), Positives = 221/332 (66%), Gaps = 4/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFG---FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 MKLAV+S K YD+ Y QV E +E+ F L+E+T A GC+AVC+FVND Sbjct: 1 MKLAVFSAKSYDRTYFDQVREQHFPELCTIEYHAFALSEETVPLAQGCDAVCVFVNDTLD 60 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 VL L +G++ I LRCAGFN+V L+ A+ELGL V VPAY PEAVAE A+ ++ TLN Sbjct: 61 ERVLRALHAYGIRAILLRCAGFNHVHLETAEELGLFVANVPAYSPEAVAEFAVALIQTLN 120 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+ HRAY R R+ NF++EGL G T++GKT G+IG G+IG+A RI GFG RLLA DP+ Sbjct: 121 RKTHRAYNRVREGNFNIEGLLGNTLHGKTVGIIGVGRIGLAAARIFHGFGCRLLAHDPFA 180 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + G VDL TL ES ++SLHCPLT HL+NE +++ G ++VNTSRG L Sbjct: 181 GEEFRQFG-TLVDLDTLLQESHIVSLHCPLTDSTKHLINEETLARIRPGSLLVNTSRGGL 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID+ A I+ALK +++G L +DVYE E ++F+ D S ++I DDV RL HNVL GHQ Sbjct: 240 IDTAAVIQALKTKQLGGLALDVYEAEGEIFYNDHSGEIIDDDVLMRLMTFHNVLICGHQG 299 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 F T EAL I++ TL NLS+L +C N LV Sbjct: 300 FFTREALEEIAEVTLGNLSDLVSARSCKNSLV 331 >UniRef50_B0KD78 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=8 Tax=Bacteria RepID=B0KD78_THEP3 Length = 332 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 87/329 (26%), Positives = 148/329 (44%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ V + + KY ++V G L E+ + + +R V+ Sbjct: 5 KVVVTDFEYANLKYEEEVLSKAGITLVPAQCKTEEELILACKDADGLI-NQYAKITRRVI 63 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L K K IA G + +D+ AA G+ VV VP Y + V++HA+ +++ R++ Sbjct: 64 EALDK--CKVIARYGIGVDTIDIKAATARGICVVNVPDYCMDEVSDHALALLLGCARKVV 121 Query: 122 RAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + + + + + GK G++G G+I + + FG +L +DPY + Sbjct: 122 LMNNAVKAGTWDFKISKPIYRLRGKVLGLVGFGRIPRTLAEKARPFGFDILVYDPYITQE 181 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +E G V L L S+SD +S+H PLT + YHL+ E MK I+NT+RG +ID Sbjct: 182 DVEPYGATLVGLEELMSKSDFVSVHAPLTEKTYHLIGETEIGLMKPSAFIINTARGPVID 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A I+AL+ ++I G+DV E E L NV+ T H A+ Sbjct: 242 EKALIKALQEKRIAGAGLDVLEQEP-------------TPSDNPLLKMDNVIITPHVAWY 288 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 + E+ + Q ++++ G + Sbjct: 289 SEESEAELRTKAAQGVADVLLGYWPKYLV 317 >UniRef50_B9L167 Phosphoglycerate dehydrogenase SerA n=2 Tax=Thermomicrobia (class) RepID=B9L167_THERP Length = 745 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 85/325 (26%), Positives = 151/325 (46%), Gaps = 19/325 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + + D++ +++ + D + +A+ + +R +L Sbjct: 204 IVVSDVIDQRARERLASEAD--VIEVDGRDKPALYEALREADALIVRSETQVTRELLAHA 261 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + ++ +A G +N+DL AA E G+ V+ P + + EH + +M+ + R + A Sbjct: 262 PR--LRVVARAGTGVDNIDLQAATEAGILVLNAPGANAVSAGEHTVALMLAIARNLIDAN 319 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALE 183 T + + F + GKT G++G G++G + + L+ F RLL +DPY + + Sbjct: 320 ATTHAGRWERKRFRPFDLKGKTIGIVGLGRVGSVVAQRLRAFECRLLGYDPYITRERFAQ 379 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 LGVE VD TL SD+++ H P TPE H+L+ A +MK G +++N +RG ++D QA Sbjct: 380 LGVEPVDYETLLENSDIVTFHVPATPETRHMLDARAIARMKPGAIVINCARGEVVDVQAL 439 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 EALK+ + + G+DV+ E L NV+ T H + EA Sbjct: 440 AEALKSGHLAAAGVDVFPEEPAYQ--------------SPLFGLPNVVLTPHIGGSSREA 485 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 L ++ + +GE PN + Sbjct: 486 LEAVGEIIATTTLAALRGEIVPNAV 510 >UniRef50_Q1PZY1 Similar to D-3-phosphoglycerate dehydrogenase (PGDH) n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZY1_9BACT Length = 535 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 148/328 (45%), Gaps = 19/328 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V ++ ++ G E+ L + C+ V + N + PVLE Sbjct: 10 MLVLIADDLP-DVCNEILQNAGVEVLKKTGLKPPELDAVIKMCDGVIVRSNTKLTAPVLE 68 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K I G +N+D+ AA + G+ V+ PA + + AEH I ++ +L+R + + Sbjct: 69 --KSEKLKAICRAGVGVDNIDVPAATKKGIVVMNTPAGNIISTAEHTIALLCSLSRFVPQ 126 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A ++ + + TG + GKT G+IG G++G + + M+++ +DP+ + + Sbjct: 127 ACASVKEGKWEKKKFTGQQLTGKTFGIIGLGRVGRQVAKRAAALEMKVIGYDPFITTEIS 186 Query: 182 LELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + + V +L L +++D I++H L E +L+ F MK GV I+N +RG +I Sbjct: 187 SQYNIHIVKNLRDLLAQADYITIHVTLNKETKNLITSKEFSLMKKGVQIINCARGGVICE 246 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + A+K ++ +DV+E E +L V+ T H T Sbjct: 247 EDLYNAIKTGQVAGAALDVFEEEPPK--------------DNKLLQLEEVIATPHLGAST 292 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + ++ G+ N + Sbjct: 293 EEAQYAVAIEAAEQMAAALTGKGYKNAV 320 >UniRef50_B4SP29 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=cellular organisms RepID=B4SP29_STRM5 Length = 334 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 174/332 (52%), Positives = 228/332 (68%), Gaps = 5/332 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF----GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 M++AV+S + YD+++L++ N+ GF +FD L TA A C AVC+FVND Sbjct: 1 MQIAVFSARPYDRRFLEEANQRDAAGDGFAFVYFDVALDVHTAALAQDCAAVCVFVNDRL 60 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 PVL L GV+ + LRCAGFNNVDL AAK L L V RVPAY PEAVAEHA+ ++MTL Sbjct: 61 DAPVLRALHALGVRAVLLRCAGFNNVDLAAAKALDLFVARVPAYSPEAVAEHALALVMTL 120 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 NR+ HRAY R R+ NF L+GL G T++G+T G++GTGKIG+A RI +G G +L DPY Sbjct: 121 NRQTHRAYNRVREGNFMLDGLLGRTLHGRTVGIVGTGKIGLATARIFRGMGCIVLGHDPY 180 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 PS+A +G E V L L + +D++SLHCPLTPE +HL+N+A+ +MK G M+VNTSRGA Sbjct: 181 PSSAFGGIG-EMVGLDELLARADIVSLHCPLTPETHHLINDASLARMKPGAMLVNTSRGA 239 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D+ A I ALK++++G L +DVYE E LFF+D S ++I D+ F+RL NVL TGHQ Sbjct: 240 LVDTHAVIRALKSRRLGHLAIDVYEQESALFFQDLSGEIIDDEAFQRLMTFPNVLVTGHQ 299 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T EAL IS TL NL + G C N + Sbjct: 300 GFFTVEALQEISAITLGNLQDFAAGRPCANRV 331 >UniRef50_B7P3M8 D-3-phosphoglycerate dehydrogenase, putative (Fragment) n=2 Tax=Coelomata RepID=B7P3M8_IXOSC Length = 473 Score = 383 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 81/326 (24%), Positives = 151/326 (46%), Gaps = 18/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V + D ++ E+ G ++ + + G +A+ + + V++ Sbjct: 7 KVLISDAVD-ASCVKILENNGVQVTLKTDFTKPELLQAIEGYDALIVRSATKVTSDVIKA 65 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 + +K I G +N+D DAA G+ V+ P + + AE M++TL+R I A Sbjct: 66 GQA--LKVIGRAGTGVDNIDCDAATRQGILVINAPGGNTLSAAELTCAMIVTLSREIPAA 123 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAAAL 182 + + + G +YGKT ++G G+IG + ++ FGM+ + FDP P + Sbjct: 124 TMSLKAGKWDRKTFMGNELYGKTLAIVGLGRIGKEVALRMQSFGMKTIGFDPIVPKEVSR 183 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E GVE + L ++ +D I++H PL P+ L+ +A+ ++ K GV I+N +RG +++ Sbjct: 184 EFGVESMSLDEIWPLADYITVHTPLIPQTKDLIGKASLQKCKKGVKIINVARGGIVNEDD 243 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + AL++ G G+DV+ E + L A V+ T H T E Sbjct: 244 LLAALESGHCGGAGLDVFLEEPPKNTQ--------------LIAHPKVVCTPHLGANTKE 289 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++Q + +L +G++ P + Sbjct: 290 AQLRVAQEIAEQFVDLSQGKSVPGVV 315 >UniRef50_B4AUS0 Glyoxylate reductase n=1 Tax=Cyanothece sp. PCC 7822 RepID=B4AUS0_9CHRO Length = 326 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 81/332 (24%), Positives = 147/332 (44%), Gaps = 21/332 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK-TAKTANGCEAVCIFVNDDGSRPVL 61 ++ T+Q ++ L + E+ + + + + + D ++ Sbjct: 4 PKIFVTRQLPERGLNPLLSHAEIEIWPERQPPAYEILLEKVQQIDGLLCLLTDRIDEQLI 63 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 K +K I+ G++N+D+ AA + V P +A A+ ++M RRI Sbjct: 64 NTGK--SLKVISQMAVGYDNIDIKAATNRKIPVGNTPGVLTDATADLTWALLMCAARRII 121 Query: 122 RAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + Q R ++ L G + G T G++G G+IG A+ R GF +R++ + Sbjct: 122 ESEQYVRAGSWQTWEPTLLLGTDLSGATLGIVGLGRIGEAVARRASGFNLRVIYSSRHRR 181 Query: 179 AAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + +E LGVEYV+ L ESD+I+LH L+ E +HL++ A F MK +++NT+RGA Sbjct: 182 SKEIEAALGVEYVEFNRLLQESDIITLHTALSKETHHLISYAQFALMKRSAILINTARGA 241 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D QA + LK+ +I +DV E E + L + N++ T H Sbjct: 242 IVDPQALYQTLKSGQIAGAALDVTEPEPI-------------PLDSPLLSLKNLIITPHI 288 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + + ++ NL + P + Sbjct: 289 GSASYQTRLKMATMAANNLLAGLLNQPLPYCV 320 >UniRef50_C7QLW6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=19 Tax=cellular organisms RepID=C7QLW6_CYAP0 Length = 336 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 172/329 (52%), Positives = 233/329 (70%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S + YD+++L N + EL +F+ LL KTA A+G AVC+FVND+ Sbjct: 1 MKVAVFSAEAYDRQFLNAANANADHELVYFETLLEPKTASLAHGFPAVCVFVNDNLDPET 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L G K +ALRC GFNNVD+ AA +LG+KVVRV Y P +VAE AIGM++ LNR+ Sbjct: 61 LKILADQGTKLVALRCTGFNNVDVTAAAQLGIKVVRVSVYSPYSVAEFAIGMILVLNRKF 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H+AY R RD NFSL GL GF ++G T GVIGTGKIG+ I+ GFG LL +D YP+ Sbjct: 121 HKAYNRVRDDNFSLNGLMGFDLHGCTVGVIGTGKIGLIFAEIMHGFGCHLLGYDLYPNPH 180 Query: 181 ALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + YVDL LF+ SD+ISLHCPLTPEN++L+N +MK GVM++NTSRG LID Sbjct: 181 FETMANAHYVDLSDLFTNSDIISLHCPLTPENHYLINTETIAKMKPGVMLINTSRGKLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++AAI+ +K+ +IGSLG+DVYE E +LFF D S+ +IQDD F+ L + NV+ T HQAFL Sbjct: 241 TKAAIKGIKSGQIGSLGIDVYEEEDNLFFRDLSDTIIQDDTFQLLQSFPNVVITAHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A++ I+ TT++++++ E+G T NE+ Sbjct: 301 TRNAISQIADTTIESITDFEQGNTLKNEI 329 >UniRef50_Q1IVI0 D-3-phosphoglycerate dehydrogenase n=3 Tax=Acidobacteria RepID=Q1IVI0_ACIBL Length = 531 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 92/330 (27%), Positives = 150/330 (45%), Gaps = 20/330 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLL-TEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V ++ K + + + + D + E+ + G +A+ + Sbjct: 1 MKIVV--AEKIAKAAIDLFKQDPTWNVVTPDQVAQKEQLLEQLKGADALIVRSAVFVDAA 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE ++ I G +N++L+AA G+ V+ P + AVAEH IG+M+ L R Sbjct: 59 MLEHA--DQLRVIGRAGVGVDNIELEAATRKGIAVMNTPGANAIAVAEHTIGLMLALARF 116 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 I RA + + + L G + GKT G++G G+IG+ + R FGM L+A DPY S Sbjct: 117 IPRATETMHAGKWEKKSLQGTELRGKTLGIVGLGRIGLEVARRAASFGMTLVAHDPYVSP 176 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A A + + D + + +D I+LH LTP+ +++N MK GV IVN +RG LI Sbjct: 177 AIAHDAKIRLADRDEVLAVADYITLHVGLTPQTANMINATTLATMKKGVRIVNCARGELI 236 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D A EA+K+ +G +DV+ E NV+ T H Sbjct: 237 DDAALAEAVKSGHVGGAALDVFTEEPLKA--------------SPYHGVPNVILTPHIGG 282 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA ++ + + + N + Sbjct: 283 STAEAQDAVGVQIAHQVRDYLQRGVVQNAV 312 >UniRef50_UPI0001AEC4CE D-lactate dehydrogenase n=1 Tax=Alteromonas macleodii ATCC 27126 RepID=UPI0001AEC4CE Length = 346 Score = 382 bits (983), Expect = e-105, Method: Composition-based stats. Identities = 160/321 (49%), Positives = 220/321 (68%), Gaps = 6/321 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFG------FELEFFDFLLTEKTAKTANGCEAVCIFVNDD 55 +A +ST+ Y+ ++ E+ FF+ L TA + +G V +FVNDD Sbjct: 20 NIAFFSTRSYEHALFSELLETLNGASDKTINATFFEHPLNASTAASCSGFSDVVVFVNDD 79 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 +R +E LK GVK+IALRCAGFNNVD+DAA + G+ V RVPAY PE VAEH I +++T Sbjct: 80 INRKTIEALKLCGVKHIALRCAGFNNVDVDAAAKAGITVSRVPAYSPETVAEHTIALILT 139 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 LNR+ H+AY R R+ NF+L GL GFT++GKT GVIGTGKIG A++RIL GFG +L FDP Sbjct: 140 LNRKTHKAYNRVREGNFNLGGLMGFTLHGKTVGVIGTGKIGQAVIRILLGFGCHVLCFDP 199 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 +P+ +G YV L L +S +++LHCPL +++H++N + ++M GVM++NTSRG Sbjct: 200 HPNNDVTTMGAHYVTLNELLEKSVIVTLHCPLNEQSHHIINAKSIDKMPQGVMLINTSRG 259 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D A I+ LK++KIG LG+DVYE E +LFF D S D+IQDD+F+RL+ NVL TGH Sbjct: 260 GLVDDNAIIKGLKSKKIGYLGLDVYERESELFFNDHSQDIIQDDIFQRLTTFPNVLITGH 319 Query: 296 QAFLTAEALTSISQTTLQNLS 316 Q F T EAL I++ T+ N+ Sbjct: 320 QGFFTLEALEEIAKITVNNIM 340 >UniRef50_C1ZMC1 D-3-phosphoglycerate dehydrogenase n=2 Tax=Planctomycetaceae RepID=C1ZMC1_PLALI Length = 546 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 87/326 (26%), Positives = 153/326 (46%), Gaps = 17/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T L+ + E+ G E++ L ++ + + + I + +L++ Sbjct: 4 VLITDNLSPAGLKILKETPGIEVDLRKGLTPDEVRVALHDADGIIIRSETKLTPEILKDQ 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K I G +N++L AA G+ V+ PA + + AEH I MMM L+R I A Sbjct: 64 PR--LKAIVRAGVGTDNINLPAATREGIVVMNTPAGNTTSTAEHTIAMMMALSRNIAPAA 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALE 183 + RD + + TG + GK+ ++G G+IG+A+ R G M++L FDP+ S A E Sbjct: 122 SKLRDGVWDRKSFTGTQLAGKSIAIVGLGRIGLAVARRAMGLEMKVLGFDPFMSVERAAE 181 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 G+E Y D+ + ++ D +++H PL+PE +L+ +MK GV I+N +RG +I+ Sbjct: 182 QGIELYRDIDEMITKCDYLTVHTPLSPETTNLIGAERLAKMKKGVRIINCARGGIINEAE 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +A+++ IG +DV+ E L VL T H A T E Sbjct: 242 LAQAIESGHIGGAALDVFVKEP-------------TPPDNPLLKLPQVLCTPHLAASTDE 288 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ + ++ + + Sbjct: 289 AQELVAVEAAEIMAGFLVRHEVRHAV 314 >UniRef50_Q9P7Q1 2-hydroxyacid dehydrogenase homolog 2 n=2 Tax=Schizosaccharomyces pombe RepID=DDH2_SCHPO Length = 332 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 143/319 (44%), Positives = 214/319 (67%), Gaps = 1/319 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++S++ YD+ ++ N++F E+ + +F L + T A + VC+FVND Sbjct: 1 MRVVLFSSQSYDRGPFEEANKTFNHEIIYHNFSLNKDTVSLAGKAQVVCVFVNDQVDADT 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L ++GVK +ALRC G+NNV+L AA E + VV VP+Y P AV+E +G++++LNR+I Sbjct: 61 LKALAENGVKLVALRCGGYNNVNLKAASEYKITVVHVPSYSPFAVSEFTVGLLLSLNRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 HRAY R R+ +F++ GL G ++GKT GVIGTGKIG + + K GFG +LA+D P Sbjct: 121 HRAYVRVREDDFNIVGLLGCDIHGKTVGVIGTGKIGSNVAKCFKMGFGCDVLAYDINPDK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 GV++V+ + ++D + LHCPLTP H++N + MK GV IVNTSRG LID Sbjct: 181 KLENYGVQFVEQNEVLKKADFLCLHCPLTPSTTHIVNSDSLALMKKGVTIVNTSRGGLID 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A ++A+ + ++G +DVYE ER+LF++D SN+VI+D F+RL NVL T HQAF Sbjct: 241 TKALVDAIDSGQVGGCAIDVYEGERNLFYKDLSNEVIKDSTFQRLVNFPNVLVTSHQAFF 300 Query: 300 TAEALTSISQTTLQNLSNL 318 T EAL SI+ TTL++ S+ Sbjct: 301 TTEALCSIAHTTLKSASDF 319 >UniRef50_P35136 D-3-phosphoglycerate dehydrogenase n=12 Tax=Bacillales RepID=SERA_BACSU Length = 525 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 82/325 (25%), Positives = 147/325 (45%), Gaps = 20/325 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + LQ + ES E+ + E T +A+ + + + ++ Sbjct: 4 VLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHT---FDALLVRSATKVTEDLFNKM 60 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K + G +N+D+D A + G+ V+ P + + AEH M+ +L R I +A Sbjct: 61 --TSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEHTFAMISSLMRHIPQAN 118 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + ++ G +YGKT G++G G+IG + + + FGM + FDP+ + A + Sbjct: 119 ISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAFGMTVHVFDPFLTEERAKK 178 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 +GV + +D+I++H PLT E LLN+ + K GV ++N +RG +ID A Sbjct: 179 IGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKTKKGVRLINCARGGIIDEAAL 238 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +EAL+N + +DV+E E V +L V+ T H T EA Sbjct: 239 LEALENGHVAGAALDVFEVEPP--------------VDNKLVDHPLVIATPHLGASTKEA 284 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ + + KG + + Sbjct: 285 QLNVAAQVSEEVLQFAKGLPVMSAI 309 >UniRef50_O04130 D-3-phosphoglycerate dehydrogenase, chloroplastic n=43 Tax=Viridiplantae RepID=SERA_ARATH Length = 624 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 17/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K + T++ + + + E + + L E K +A+ + +R V Sbjct: 82 KPRILVTEKLGEAGVNLLREFGDVDCSY--DLSPEDLKKKVAESDALIVRSGTKVTREVF 139 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E K +K + G +NVDL AA E G VV P + A AEH I ++ ++ R + Sbjct: 140 EAAK-GRLKVVGRAGVGIDNVDLQAATEHGCLVVNAPTANTVAAAEHGIALLASMARNVA 198 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAA 180 +A + + G ++ GKT V+G GK+G + R KG GM +++ DPY P+ Sbjct: 199 QADASIKAGKWERSKYVGVSLVGKTLAVMGFGKVGTEVARRAKGLGMTVISHDPYAPADR 258 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A LGV+ V S +D +SLH PLTP + N+ F +MK GV ++N +RG +ID Sbjct: 259 ARALGVDLVSFDQAISTADFVSLHMPLTPATKKVFNDETFSKMKKGVRLINVARGGVIDE 318 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + AL + +DV+ E RL NV T H T Sbjct: 319 DALVRALDAGIVAQAALDVFCEEPPSK-------------DSRLIQHENVTVTPHLGAST 365 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA ++ + ++ KGE + Sbjct: 366 KEAQEGVAIEIAEAVAGALKGELSATAV 393 >UniRef50_C1SGT4 D-3-phosphoglycerate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SGT4_9BACT Length = 544 Score = 379 bits (974), Expect = e-104, Method: Composition-based stats. Identities = 84/329 (25%), Positives = 150/329 (45%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V T + + + E++ + K +A+ + ++ Sbjct: 3 KYKVLITDHISQDGVNILKSDKDIEVDIQAGIKNPDLKKIIGNYDAIITRSGTTVTAELI 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E K +K I G +NVD++AA G+ V+ P + A E +GMM+++ R++ Sbjct: 63 ENPGK--LKIIGRAGVGLDNVDIEAASMKGIIVMNAPTGNTLAACELTMGMMLSVVRKLP 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-A 180 A Q T+ + + G +Y KT V+G G+IG + + K F M+++A+DPY Sbjct: 121 LANQVTKSGEWDRKRFMGIQLYQKTLAVVGLGRIGGNVAKRCKAFDMKVVAYDPYIKKSR 180 Query: 181 ALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGVE L S++D+I+ H PLT E +L+ + +MK+GV+I+N +RG +++ Sbjct: 181 AESLGVELCNSLEEAISQADIITFHTPLTDETKNLITKDEIAKMKDGVVIINCARGGIVN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A K+ K+ + G+DV+ +E V N+ T H Sbjct: 241 ELDLVDACKSGKVTAAGLDVFMSEPP--------------VNHPFFDVENIYVTPHIGAN 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAE ++ + + N G + N + Sbjct: 287 TAEGQYGVAVIIAEQVVNALHGRSYKNAV 315 >UniRef50_C9LMC8 Phosphoglycerate dehydrogenase n=1 Tax=Dialister invisus DSM 15470 RepID=C9LMC8_9FIRM Length = 530 Score = 378 bits (973), Expect = e-103, Method: Composition-based stats. Identities = 93/326 (28%), Positives = 152/326 (46%), Gaps = 17/326 (5%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 ++ T K+ + + + F ++ + ++ K +AV ++ V+ Sbjct: 3 KIFITADVAKEAKEFLEKE--FVVDIRPNMDEDELCKVIGEYDAVITRSQTKITKNVIHA 60 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 +K I G + +D+ A G+ VV P + A EH + +M+++ R I +A Sbjct: 61 A--TNLKVIGRAGVGIDGIDIPEATAKGITVVNTPESNTIAACEHTLALMLSITRYIPQA 118 Query: 124 YQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAAL 182 +Q + + + TG + KT G+IG G++G + + L+ F M+ + +DPY P Sbjct: 119 HQSIMEGRWDRKSFTGIQLLNKTVGIIGVGRVGSNVAKRLQAFNMKTIGYDPYIPLERGQ 178 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 +LGV+ VDL TL ESD I+LH PLT E ++ E+MK+GV IVN SRGA+ID A Sbjct: 179 QLGVDLVDLDTLLRESDYITLHTPLTEETKGMIGAKEIEKMKDGVRIVNASRGAVIDIDA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 EALK K+ G+DV+ NE NV T H T E Sbjct: 239 LAEALKTGKVAGAGIDVWTNEPLK------------PENNPFLGMKNVTLTPHLGASTVE 286 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A T ++ + +++ GE + Sbjct: 287 AQTGVATDVARGVADALHGEPVATAV 312 >UniRef50_B0TB58 Glyoxylate reductase n=7 Tax=cellular organisms RepID=B0TB58_HELMI Length = 328 Score = 378 bits (973), Expect = e-103, Method: Composition-based stats. Identities = 93/332 (28%), Positives = 152/332 (45%), Gaps = 20/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEF-FDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 + V T++ + L ++ E +L F + + +A+ + D V Sbjct: 6 RPKVLVTREIPQPALDRIKEFARLDLWPAFPPPEKGELQRMLADADALLCMITDPIDDDV 65 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E KK ++ IA G++N+D+ AA + V P EA A+ A +++ R + Sbjct: 66 IEAGKK--LRVIANYGVGYDNIDIAAATRRRIAVTNTPDALTEATADLAFALLLATARNL 123 Query: 121 HRAYQRTRDA---NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 A + TRD + + L G ++G T G++G G+IG A+ R +GF M +L Sbjct: 124 IAADRFTRDGFWIAWHPQLLLGRDVFGSTLGIVGLGRIGEAVARRARGFNMHVLYTARRR 183 Query: 178 SAAAL-ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + A ELG+EY L L SD +SLH PLT E HL+ MK +++NT+RG Sbjct: 184 NPKAEAELGIEYCTLEELLRRSDFVSLHTPLTLETRHLIGAKELNMMKPTAILINTARGG 243 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D +A EAL+ IG G+DV+ E L NV+ + H Sbjct: 244 VVDQEALTEALQQGVIGGAGLDVFAEEPVA-------------PEEALLELPNVVVSPHI 290 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA T + ++N+ + +G PN + Sbjct: 291 GSATVEARTRMGLMAVENIQAVLEGRRPPNLV 322 >UniRef50_D2RMS7 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RMS7_ACIFE Length = 529 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 153/329 (46%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V ++ K ++ + E+ + E+ K +A+ + + Sbjct: 3 KKKVIVVERISDKGVEMLKAQPDLEVTVKFDIPREELLKIVGDYDAIIVRSVTKVNEEFY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + +K + G +N+D++ A + G+ VV P + + AEH IG+M+ R Sbjct: 63 QAA--RNLKVVGRAGNGVDNIDIEGATKRGIIVVNTPEANVISAAEHTIGLMLASCRNTV 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAA 180 +A + + + L G +Y KT G+IG G+IG + + ++ F M+++A+DPY P + Sbjct: 121 KAQKMIESRVWDRKNLKGVELYHKTLGIIGLGRIGTLVTKRMQAFEMKVIAYDPYIPDSR 180 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LGVE + L L +++DVI++H P T E +++ + ++ K GV +VN +RG L + Sbjct: 181 FKRLGVEKCETLDDLLAKADVITIHTPKTEETINMIGKEELKKCKKGVRLVNCARGGLYN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA +A+K ++ S+G+DV +E L + T H Sbjct: 241 EQAVADAIKEGQVASIGLDVLVDEP--------------KPISPLIGLEQCVLTPHLGAD 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA + + Q + N+ G+ PN + Sbjct: 287 TVEAQDKVGISIAQEVVNVLNGQMVPNAV 315 >UniRef50_Q5HNI1 D-3-phosphoglycerate dehydrogenase n=73 Tax=Staphylococcus RepID=Q5HNI1_STAEQ Length = 531 Score = 377 bits (970), Expect = e-103, Method: Composition-based stats. Identities = 79/329 (24%), Positives = 154/329 (46%), Gaps = 17/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + + + LQ + + F+++ L + +A+ + + + Sbjct: 1 MSHKILVSDPISEDGLQSILKHPEFDVDIQTDLSENDLVNMISTYDALIVRSQTQVTERI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +K IA G +N++++AA G+ V+ P + + EH++ M++ + R I Sbjct: 61 INAA--TNLKVIARAGVGVDNINIEAATLKGILVINAPDGNTISATEHSVAMLLAMARNI 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+Q R+ ++ + G +YGKT GVIG G+IG+ + + + FGM++LAFDPY + Sbjct: 119 PQAHQSLRNKEWNRKAFRGVELYGKTLGVIGAGRIGLGVAKRAQSFGMKILAFDPYLTED 178 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A L ++ + + +SD +++H PLTP+ ++ + F + K + I+N +RG +ID Sbjct: 179 KAKSLDIQIATVDEIAEKSDFVTVHTPLTPKTRGIVGSSFFNKAKQNLQIINVARGGIID 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A IEAL N I +DV+E+E L ++ T H Sbjct: 239 ETALIEALDNNLIDRAAIDVFEHEPPT--------------DSPLIQHDKIIVTPHLGAS 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ + + + + + + Sbjct: 285 TVEAQEKVAVSVSEEIIEILTKGNVEHAV 313 >UniRef50_Q22CX9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain containing protein n=3 Tax=cellular organisms RepID=Q22CX9_TETTH Length = 359 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 155/333 (46%), Positives = 218/333 (65%), Gaps = 5/333 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFE----LEFFDFLLTEKTAKTANGCEAVCIFVNDDGS 57 ++AV+S K+YD K+ Q+NE E ++F+ L EKTA G + +C FVND + Sbjct: 23 RVAVFSAKKYDIKFFNQINEKLPIEKRIIFDYFEEELNEKTAILTQGYDVICPFVNDKLN 82 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 +P ++ L K+G+ IALRCAGFNN DL+ A++ +KVVRVPAY P AVAEH + ++++L Sbjct: 83 QPTIQTLAKNGIDLIALRCAGFNNTDLECAQKNNIKVVRVPAYSPHAVAEHTMALLLSLV 142 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R+IH+AY RT+D NFSL+GL GF +Y K G+ GTGKIG + I +GFGM +L DPYP Sbjct: 143 RKIHKAYNRTKDGNFSLDGLLGFDLYKKKIGIFGTGKIGQTFMGICQGFGMEILCHDPYP 202 Query: 178 SAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + + YVD TLF E D+ISLHCPLT ++++ + MK G +I+NT RG Sbjct: 203 NEEVVKKYNARYVDQATLFKECDIISLHCPLTFSTQYVIDRKTIDIMKKGAIIINTGRGK 262 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+ + I ALK+ ++G + +DVYE+E FF+D S DVI DD RL NV+ T HQ Sbjct: 263 LMRTDEVIAALKSGQLGGVALDVYEHEEGYFFKDVSADVIYDDDLARLLMYPNVIVTSHQ 322 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AF T EA+T+I QTT+ N+ ++ E C N ++ Sbjct: 323 AFFTQEAITAICQTTIDNILKIKANEPCDNMVL 355 >UniRef50_Q46AE6 Glycerate dehydrogenase n=2 Tax=Methanosarcina RepID=Q46AE6_METBF Length = 323 Score = 376 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 100/329 (30%), Positives = 165/329 (50%), Gaps = 18/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V + ++Y ++++ ++ E+ + V + S Sbjct: 1 MKIVVSDSIFLPEEYRKKLDALGDLKVFESMPSSIEEFISRVRDADIVLVGRYG-FSGKA 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ +++ G++++DL AA E G+ V VP Y ++VAE + + L R++ Sbjct: 60 FNA--SRNLQMLSVWQTGYDHIDLKAATEKGVIVSNVPDYAFDSVAEMVFALALNLLRKV 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 H A R R+ NF G + GKT GVIGTG IG +++I GF M +++ +PS Sbjct: 118 HVADIRLREGNFDWRHYFGSQIMGKTMGVIGTGSIGSRVIQIAHGFNMNVISVTGHPSEE 177 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGV++VDL TL +E+D+++LH PLTP ++ +MK +++NT+RG ++D Sbjct: 178 KARSLGVKFVDLDTLLAEADIVTLHVPLTPSTEKMIGAKELAKMKKSAILINTARGKVVD 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A IEALK +KI G+DV+E E L A NV+ T H AFL Sbjct: 238 EAALIEALKEKKIRGAGLDVFEKEPL-------------PANDPLKALENVVLTPHIAFL 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E+L + +QN+ +G+ N + Sbjct: 285 TEESLEECTYVCVQNVERFIEGK-PQNIV 312 >UniRef50_A5GES6 D-3-phosphoglycerate dehydrogenase n=12 Tax=Desulfuromonadales RepID=A5GES6_GEOUR Length = 541 Score = 376 bits (967), Expect = e-103, Method: Composition-based stats. Identities = 90/329 (27%), Positives = 154/329 (46%), Gaps = 16/329 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T + ++ L+ + + EL+ L E+ E + + + Sbjct: 1 MKVIV--TDEVAQEGLELLKQDPRVELDIRLGLKKEELLAIIGDYEVIITRSGTTVDKDL 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ KK +K +A G +NVD+D A G+ VV P + + AEHA+ ++++ R I Sbjct: 59 LDAGKK--LKMVARAGVGIDNVDIDYASSKGVIVVNAPFGNTNSAAEHAMALLLSFCRNI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-A 179 +A + + TG + GKTAGVIG GK+G + LK F +L DPY + Sbjct: 117 TKANASLKSGEWKRAPFTGVELKGKTAGVIGLGKVGGRVATRLKAFECDVLGCDPYIAVK 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A +LGV+ V ++ D+I+ H PL E +++ E MK+GV+++N +RG +I+ Sbjct: 177 RAHDLGVKLVSHEEIYKNCDIITFHTPLNEETRNMVGEKEIAMMKDGVILINAARGGIIN 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA + ALK K+ MDV+ E + + L + ++ T H Sbjct: 237 EQALLNALKGGKVFGAAMDVWSEEPPKS-----------ETLKELISQDKLVVTPHLGAN 285 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA +++ + + N + N + Sbjct: 286 TFEAQINVAVDVSKEILNYLDEQPLENAV 314 >UniRef50_A5IK90 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=6 Tax=Thermotogaceae RepID=A5IK90_THEP1 Length = 327 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 87/333 (26%), Positives = 148/333 (44%), Gaps = 28/333 (8%) Query: 1 MKLAVYSTKQYDKKYLQ--QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK + T+ + K + + + GFE+ D + + +A+ + + Sbjct: 1 MKKVLIVTRTFGKYSQEPVEFLKKEGFEIIRSDTIDPD----ILKEVDALIV-GTHPVTA 55 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 ++E +K IA G +N+DL+AA + G+ V + +VAE I + L R Sbjct: 56 EMIEN---SSLKVIAKHGVGVDNIDLEAATKKGIPVTITAGANSLSVAELTIAFIFALIR 112 Query: 119 RIHRAYQRT-RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + A+ + + + G G + GKT GV+G G IG +++ GM +L +DPY Sbjct: 113 GLVWAHNKLFLERKWE--GTVGQEVSGKTLGVVGFGSIGREVVKKAVCLGMNVLVYDPYV 170 Query: 178 SAAALEL-GVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 S + L VD L L ESD +SLH PL +++ E MK ++NTSRG Sbjct: 171 SKDNVRLLEATPVDDLDQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRG 230 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D +A ++ALK +I +DV+ E + L C N++ T H Sbjct: 231 GLVDEEALVKALKEGRIAGAALDVFSEEPP-------------NPNSPLFKCPNLITTAH 277 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E++ ++ Q++ + KG + Sbjct: 278 IGAHTKESILRMNMMAAQSVVDFFKGNIPKYVV 310 >UniRef50_A6C2G1 Phosphoglycerate dehydrogenase (SerA) n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C2G1_9PLAN Length = 316 Score = 375 bits (965), Expect = e-102, Method: Composition-based stats. Identities = 92/326 (28%), Positives = 148/326 (45%), Gaps = 19/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V T+ + ++ + E + + + + + A+ + R +++ Sbjct: 4 VLVTENIQGVSMNRLIQEHDVEFDAYLWQNIDLLKQKIQNTRALIVRNQTKVDRELIDAA 63 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K IA AG +NVD + A E G+ V P + +VAE IG+M+ L R+I A Sbjct: 64 PE--LKIIARAGAGLDNVDTEYAHEKGIVVCFTPDANSLSVAELTIGLMLALMRKIPEAR 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA--- 181 Q T ++ TG +YGK+ G+IG G+IG K FGM +LA DP+ A A Sbjct: 122 QDTLTGGWNRLKFTGTELYGKSFGLIGLGRIGSFTATRAKAFGMNILAADPFLKADAPQL 181 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +L + L L +ESDV+S H PLTP+ +L F +MK +NTSRG ++D + Sbjct: 182 KKLNATLLSLDDLLAESDVVSCHSPLTPDTRKMLTYQHFRKMKPDAFFINTSRGEVVDER 241 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 +AL K+ +DV E E L+ NV+ T H A T Sbjct: 242 GLTQALLEHKLAGAALDVRETEPPKQ--------------SPLNQMENVILTPHIAAFTV 287 Query: 302 EALTSISQTTLQNLSNLEKGETCPNE 327 EA + + +++ + G+ N Sbjct: 288 EAQDRVVDSVCEDVRLVLSGKKAINV 313 >UniRef50_A9A5A9 Glyoxylate reductase n=2 Tax=Thaumarchaeota RepID=A9A5A9_NITMS Length = 322 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 80/335 (23%), Positives = 148/335 (44%), Gaps = 22/335 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTE-KTAKTANGCEAVCIFVNDDGSRP 59 M+ V+ T+ L+++ + + E+ + + K + + F D ++ Sbjct: 1 MRKKVFLTRTLHDFALKELKKKYQIEVHKGKIPVPQSKLRSKIKDVDGLICFPYDIINKE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 ++ +K I+ GF+++D AK ++V P +A A+ A +++ RR Sbjct: 61 TIDLA--ENLKVISTYSVGFDHIDTKYAKGKKIRVGYTPEVLTDATADLAFSLLLDSLRR 118 Query: 120 IHRAYQRTRDANFS----LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + + RD + G + GKT G++G G+IG + + K F M ++ + Sbjct: 119 VSEGDRIIRDGKWKMIYGAHDYVGVDLQGKTIGILGLGRIGQTLAKRAKAFDMDIIYHNR 178 Query: 176 YPSAAALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + E L +YV L S+SDVIS+H P T E + N F++MKN ++NTS Sbjct: 179 NRLSKTKERTLDAKYVSFERLISQSDVISIHVPHTKETDKMFNMKIFKKMKNTAFLINTS 238 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +++ + + ALK + I G+DV+E E L+ NV+ Sbjct: 239 RGKVVNEKDLVTALKKKIIAGAGLDVFEQEPISK-------------NHPLTKLQNVVLA 285 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E +++ T++NL+ G+ + Sbjct: 286 PHIGSSTKETRAKMAEITVRNLNLGMNGKKPIYSV 320 >UniRef50_A1HQU2 Glyoxylate reductase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HQU2_9FIRM Length = 324 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 78/332 (23%), Positives = 134/332 (40%), Gaps = 19/332 (5%) Query: 1 MKL-AVYSTKQYDKKYLQQVNESFGF-ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK V + L +++ + + + + + E + + Sbjct: 1 MKKYQVVVAGKMRPCALAKISSECHVRQWDKIEPIPRNLLYEWLADAEGLVSTGDVRVDD 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +L + ++ IA G++NVD+ A G+ P EA A+ G+++ R Sbjct: 61 ELLAHAPR--LRVIAQASVGYDNVDIAACTRRGIPFGNTPGVLVEATADLTFGLLLCAAR 118 Query: 119 RIHRAYQRTRDANF--SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 RIH + + + + + G +YGKT G++G G+IG A+ R K GM+++ + Sbjct: 119 RIHEGWNQVASGRWLNNHDVPFGIDLYGKTLGIVGMGRIGAAVARRAKACGMKVIYHNRS 178 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 LG YV L +++D I + PL+P + + A F +MK +N +RG Sbjct: 179 RRTDDEHLGATYVAFDDLLAQADCIVVLVPLSPASQGMFGRAEFAKMKRTAYFINAARGG 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D+QA +ALK +I +DV + E L NVL T H Sbjct: 239 LVDTQALYDALKEGQIAYAALDVTDPEPL-------------PGDHPLLTLPNVLITPHI 285 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E ++ T NL P + Sbjct: 286 GSATHETRDRMAMLTADNLLAGLARRPLPACV 317 >UniRef50_A6CKS4 Putative uncharacterized protein n=2 Tax=Bacillaceae RepID=A6CKS4_9BACI Length = 322 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 93/331 (28%), Positives = 155/331 (46%), Gaps = 20/331 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V + K+ + + E G E+ E + +A+ I SR V Sbjct: 1 MNFKVLIPQPIAKEGID-LLEKEGAEVIIPPDYNEETLISHVSDVDAILIR-TAKLSRVV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+ K +K IA G +N+DL+AA + G+ V P + AVAEH + ++++ +R++ Sbjct: 59 IEKASK--LKVIARHGIGVDNIDLEAASDRGILVTNAPFANVNAVAEHVLTLILSGSRQL 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 + R+ +F G + GKT GV+G G IG + G GM +L +DPY Sbjct: 117 IQVDSALRNGDFEVRNRKFGIELKGKTLGVVGFGNIGQLVAEKCHYGLGMDVLVYDPYVR 176 Query: 179 AAALELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + V+ L + + SD++++H P P +HL+NE A +QMK ++VN +RG + Sbjct: 177 EENVSSYVQLNQSLSEVLASSDIVTIHVPYLPSTHHLINEEALQQMKKDAILVNAARGGI 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID A +AL + +I +D +E E V L NV+ T H A Sbjct: 237 IDEIALEKALGSGEIRGACLDCFETEPPA-------------VDHSLWNLENVIVTPHLA 283 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+ ++ T +++ + KGE + Sbjct: 284 AHTEEAMIEMAVTPAKDIIAIMKGEKPLYPV 314 >UniRef50_C9MSC4 Glycerate dehydrogenase n=3 Tax=Prevotella RepID=C9MSC4_9BACT Length = 316 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 88/334 (26%), Positives = 149/334 (44%), Gaps = 24/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + L + ++ E + A + + I + + V Sbjct: 1 MKIVILDCHAVNPGDLSWEPIKQLADCTIYERTRQEDVVERAKDADGILI-NKVNITEEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++L K +KYI G+NN+D+ AA+ G+ V +PAY ++VA+H +++ R+ Sbjct: 60 LQQLPK--LKYIGELATGYNNIDIAAARARGVVVCNIPAYSTDSVAQHVFALLLNAATRV 117 Query: 121 HRAYQRTRDANFSL------EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 + R + + GKT G++G G IG + +I GM + A+ Sbjct: 118 DHYAEAVRRGEWCKQQDFCYWDTPLIELAGKTLGIVGLGHIGQKVAQIAHAMGMDISAY- 176 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 ++ L + L LFS SDVI+LHCPLT EN H++N ++M+ G +++NT R Sbjct: 177 TSKNSTDLPECIRKTTLEGLFSTSDVITLHCPLTAENAHMINAERLQKMRPGTILINTGR 236 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G LID QA +AL++ + + DV +E L N T Sbjct: 237 GGLIDEQAVADALESGHLKAYCADVMTDEPPRK-------------DNPLLQQPNAYITP 283 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H A+ T EA + ++N+ +G T N + Sbjct: 284 HVAWATREARERLMAIAVENIRKFIEG-TPQNCV 316 >UniRef50_UPI0000DB72A4 PREDICTED: similar to 3-phosphoglycerate dehydrogenase n=2 Tax=Apocrita RepID=UPI0000DB72A4 Length = 478 Score = 373 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 80/325 (24%), Positives = 143/325 (44%), Gaps = 16/325 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + D ++ G + L EK K E + + + V Sbjct: 8 VLISDPVD-ACCGELLVRHGIPVTTKYKLSKEKLIKELQNHEGLIVRSETKVTADVFACC 66 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ + G +N+DL+AA G+ V+ P + + E ++ L R + +A Sbjct: 67 P--NLRVVGRAGTGVDNIDLEAATRKGVIVLNTPGGNSISACELTCALISNLARNVTQAV 124 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE- 183 Q +D + + +GF + GKT V+G G+IG + R ++ +GMR++AFDP ++ Sbjct: 125 QSLKDGRWDRKLYSGFELSGKTLAVLGMGRIGREVTRRMQAYGMRVIAFDPLLTSEDANY 184 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 L VE L ++ +D I++H PL P+ +L+N + K GV I+N +RG ++D +A Sbjct: 185 LNVEKFSLDEIWPMADYITVHTPLIPQTKNLINATTLAKCKKGVRIINVARGGIVDEEAL 244 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 + ALK+ +DV+ E ++ V L A V+ T H T EA Sbjct: 245 LNALKSGHCAGAALDVFTEEPP-----------KNSVILELIAHPKVISTPHLGASTEEA 293 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ Q + G + + Sbjct: 294 QQRVAEEIAQQFL-VLAGRSTEYVI 317 >UniRef50_C8WI96 D-3-phosphoglycerate dehydrogenase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WI96_EGGLE Length = 526 Score = 373 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 93/330 (28%), Positives = 156/330 (47%), Gaps = 19/330 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V T++ + L V G E++ + E+ +T G +A+ + + V Sbjct: 1 MTKKVLVTERLAEAGL-AVLRDKGCEVDVKLKMTPEELIETVPGYDALIVRSATKVTAEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E + ++ I G +NVD++AA E G+ V P + + AEHAIG+M+ R++ Sbjct: 60 VEAADR--LRIIGRAGVGVDNVDVEAATEHGIIVCNAPTSNIVSAAEHAIGLMLACARKV 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + + TG +Y KT + G G+IG + + FGM+L+ +DPY S Sbjct: 118 PQANASMHEGVWERGKYTGVELYEKTLAIFGLGRIGGLVAERARAFGMKLIGYDPYCSPE 177 Query: 181 -ALELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A +LGV Y D+ L +D I++H P T E + + +MK+GV++VN +RG + Sbjct: 178 RAEQLGVTLYDDVDALVPLADFITVHLPKTKETIGMFGPDQYARMKDGVILVNAARGGIF 237 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D ++ + L KIG++G+DV+E+E L N + T H A Sbjct: 238 DEKSLADFLAAGKIGAVGIDVHESEPCT--------------DSPLREFDNAILTPHIAA 283 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA T + ++ +G P L Sbjct: 284 STQEAQLRAGVQTAEYVAAGLEGSIVPTAL 313 >UniRef50_C0A4H0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Opitutaceae bacterium TAV2 RepID=C0A4H0_9BACT Length = 345 Score = 373 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 160/328 (48%), Positives = 217/328 (66%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S+K YD+++ N +L +F+ LT +TA A+G EAVC FVND Sbjct: 1 MKIAVFSSKSYDRRFFDAANTLHRHQLSYFEARLTRETAPLAHGFEAVCAFVNDRLDSGA 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L + GV + LR AG+N+ DL+AA +L + V VP Y P +VAEHA +M+ LNRRI Sbjct: 61 LARLSEAGVNLLLLRSAGYNHADLEAAADLNIVVTHVPNYSPHSVAEHAAALMLALNRRI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A+ R R+ NFS+EGL GF M+GKTAG+IG G IG RIL+GFG ++LA+DP PS Sbjct: 121 PHAFVRVREGNFSIEGLLGFDMHGKTAGLIGAGHIGAITGRILQGFGCKVLAYDPAPSEQ 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A+ E+ L + S SD++SLHCPLTP HL+ K G M++NTSRG LID+ Sbjct: 181 AVAANFEFGMLEDVISASDIVSLHCPLTPSTRHLIGRLTLPWFKRGAMLINTSRGGLIDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A IE+L+N +GSLG+DVYE+E ++FFED S + DDVF RL A NVL TGHQ F T Sbjct: 241 RAVIESLENGLLGSLGIDVYEDEAEIFFEDHSRQGLGDDVFSRLIAMPNVLVTGHQGFFT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA+ +I++T+L+ ++ G TC + L Sbjct: 301 EEAMQTIAETSLKAATDFAAGRTCAHVL 328 >UniRef50_A1W7V5 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Bacteria RepID=A1W7V5_ACISJ Length = 337 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 117/339 (34%), Positives = 187/339 (55%), Gaps = 15/339 (4%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T++++ + Q++ G +L L N E + FV+ + V Sbjct: 1 MKILVVETEEWEHRACQRLL--PGHKLVCRSNALGPDEPTADNDAEVITPFVHSRLTAEV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L + + ++ IA R G++++DLD + G+ V VP Y VAEHA +++ ++R I Sbjct: 59 LAQFPR--LRLIATRSTGYDHIDLDYCRAHGIAVSNVPDYGDATVAEHAFALLLAVSRHI 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +RTR +FS GL GF + GKT GV+GTG+IG ++ I KGFGM+++A+D +P AA Sbjct: 117 VTGAERTRRGDFSQHGLRGFELRGKTLGVLGTGRIGRRVIEIGKGFGMKIVAYDLFPDAA 176 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E LG EY+DL L S++DV++LH P TP+ +HLL + F MK G +++NT+RG ++D Sbjct: 177 VAEHLGYEYLDLHVLLSQADVVTLHVPATPQTHHLLGDPEFAAMKKGAVLINTARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFE---------DKSNDVIQDDVFRRLSACHNV 290 + A + AL +K+ + G+DV E + E + D+ L NV Sbjct: 237 TSALVRALSARKLRAAGLDVLPAEPLIREEAEIFRNDRRNSDTDLRALLADHVLLRFSNV 296 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 + T H A+ T EAL I TT+ N+ +G+ N ++ Sbjct: 297 IVTPHVAYDTDEALRRILDTTIANIEAFARGQ-PRNLVL 334 >UniRef50_D1YY17 Glycerate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YY17_METPS Length = 326 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 102/329 (31%), Positives = 158/329 (48%), Gaps = 18/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + +Y +++ E E + I S Sbjct: 1 MKIVISEPIYLTDEYRRRLEALGDLRAYDSVPTSDEDFVSRIKDAE-IVIAGRYGFSGES 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + G+K IAL G++NVDL AA G+ V V Y + VAE A + + L R++ Sbjct: 60 IRRAP--GLKMIALWQTGYDNVDLAAATARGVVVSNVHNYAFDTVAEFAFALALNLLRKV 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A R F G + GKT GVIG G IG +++I GF M +L+ +P Sbjct: 118 DKADLNLRRGLFDWRRYVGEELMGKTLGVIGLGSIGRRVVQIAHGFNMSVLSVTAHPDPE 177 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LGV++V L TL +ESDV+SLH PLTPE H++ A +MK +++NT+RG ++D Sbjct: 178 RARALGVKFVSLDTLLAESDVVSLHVPLTPETEHMIGAAQLARMKPTAILINTARGKIVD 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A +EAL+ ++I G+DV+E E + L NV+ T H AFL Sbjct: 238 EKALVEALREKRIAGAGLDVFETEPL-------------PMDSPLLKLDNVVLTPHIAFL 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 + E++ ++ T++N+ KG N + Sbjct: 285 SKESIDECTRVTMENVEMFVKGR-PQNVV 312 >UniRef50_A1HSQ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HSQ7_9FIRM Length = 317 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 91/331 (27%), Positives = 151/331 (45%), Gaps = 22/331 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDDGSR 58 K+ V + + V E G E+ F + L ++ + G +A+ D + Sbjct: 3 KVLVTARSFAKSPEARAVLEQAGCEVIFNPYDRPLTEDELVELIKGMDALVA-GMDAVTA 61 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V+ +K IA G+N +D+ AA G+ V P + +VAE AIG+M+ + R Sbjct: 62 KVI-AAGLPTLKIIAKHGVGYNTIDVAAAAAYGIPVTITPGANNISVAELAIGLMLAVAR 120 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 I + R +S +TG +YGK G+IG G IG + + FGM+++A+D P Sbjct: 121 HIPQMDGIVRRGGWSR--MTGSELYGKVLGIIGMGSIGCEVAKRAHAFGMKIIAYDIRPR 178 Query: 179 AAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +E GV Y+ + +++D +SLH P PE ++N+ + MK ++NT+RG L Sbjct: 179 QDMIENYGVTYLPMADCLAQADFLSLHAPALPETIGMINKDTLKTMKRTAFLINTARGDL 238 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 I + +ALKN I G+D + +E RL NV+ T H Sbjct: 239 IVEEDLYDALKNGVIAGAGLDTFVHEPIR--------------DARLFTLDNVVLTPHAG 284 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+T + + + + G+ N + Sbjct: 285 ATTHEAVTRMGVMAAEEVVRVLSGQPPQNPV 315 >UniRef50_B7KZ64 D-3-phosphoglycerate dehydrogenase n=16 Tax=cellular organisms RepID=B7KZ64_METC4 Length = 535 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 146/330 (44%), Gaps = 20/330 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFL--LTEKTAKTANGCEAVCIFVNDDGSRP 59 K V T +Q G E++F L E A + + I + Sbjct: 8 KPKVLITDALSDAAVQIFR-DRGIEVDFQPGLGKDKEALAAIIGQYDGLAIRSATKVTDK 66 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +L + + +K I G + +D+ AA G+ V+ P + AEHAI ++ L R+ Sbjct: 67 LLAQATR--LKVIGRAGIGVDTIDVPAATARGVIVMNTPFGNSITTAEHAIALIFALARQ 124 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 I A T+ + G + KT GV+G G IG + G ++++A+DP+ + Sbjct: 125 IPAADASTQAGKWEKNRFMGVELTAKTLGVVGCGNIGAVVADRAIGLKLKVIAYDPFLTP 184 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A E+GVE V+L L + +D+I+LH PLT + +LL+E + K GV IVN +RG L+ Sbjct: 185 ERAFEIGVEKVELDELLARADIITLHVPLTDKTRNLLSEENLAKTKRGVRIVNCARGGLV 244 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D A AL++ + +DV+ E + L NV+ T H Sbjct: 245 DEIALRAALESGHVAGAALDVFVTEPAI--------------ENPLFGHPNVICTPHLGA 290 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T+EA +++ + +++ N + Sbjct: 291 ATSEAQENVALQIAEQMADYLLSGAITNAI 320 >UniRef50_B9ZMK9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZMK9_9GAMM Length = 331 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 156/315 (49%), Positives = 215/315 (68%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+AV+S +Q+D ++L + G E + LTE+T A G +AVC+F NDD R V Sbjct: 1 MKVAVFSIQQHDHEHLVPGLTAAGMEPVVYAERLTEETIHLAAGVDAVCVFTNDDLKRGV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ L G++ IALRC+G++N+D+ A+E G++V RVPAY P AVAEHA+ +++TLNR + Sbjct: 61 IDGLADQGIQVIALRCSGYDNLDVGRARERGVRVGRVPAYSPNAVAEHAVALLLTLNRSV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRA+ RTR +F L+ LTGF + G+T GV+GTG+IG RI+ GFG R+LA DPYP+A Sbjct: 121 HRAWDRTRRGDFRLDHLTGFDLVGRTVGVVGTGRIGQVFARIMLGFGCRVLAHDPYPNAE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +GVEY DL TL +ES V+SL CP+TPEN H++N +M G ++NT+RGAL+D+ Sbjct: 181 LQAVGVEYRDLDTLLAESSVVSLSCPMTPENRHMINADTLARMPRGAFLINTARGALVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AA AL + ++G +DVYE E LFF D S + D RL +VL TGHQAFLT Sbjct: 241 DAAEIALDSGQLGGFALDVYEAEAGLFFRDWSLAGLPDRRLARLMQRDDVLVTGHQAFLT 300 Query: 301 AEALTSISQTTLQNL 315 EALT+I+ TT+ NL Sbjct: 301 HEALTNIADTTVSNL 315 >UniRef50_D1CAH7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1CAH7_SPHTD Length = 348 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 119/335 (35%), Positives = 176/335 (52%), Gaps = 13/335 (3%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 ++ + T ++ Y + F L E + A E V +F++ RP L Sbjct: 11 RVVFFETDSREQAYFGEAL--GPLAPVFHSEPLDEDSTHLAAEAEIVSVFIHSRLDRPTL 68 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L + ++ IA R G++++DL A E G+ V VP Y VAEH G+++ L+R IH Sbjct: 69 ERLPR--LRLIATRSTGYDHIDLAACAERGVVVTNVPYYGENTVAEHTFGLILALSRNIH 126 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 RAY RT+ +FSL GL GF + GKT GVIGTG IG+ ++RI KGFGM ++A D PS Sbjct: 127 RAYVRTQRGDFSLAGLEGFDLKGKTLGVIGTGSIGLHVIRIAKGFGMEVVAHDLRPSRIL 186 Query: 182 LE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E LG YV L L SD+ SLH P P +HL+N F +MK G +++NT+RG L+D+ Sbjct: 187 PEVLGFRYVPLDELLQVSDIASLHVPYLPATHHLMNRETFARMKRGSLLINTARGGLVDT 246 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDD-------VFRRLSACHNVLFT 293 ++ + AL + G+DV E E + E + + L+ NV+ T Sbjct: 247 ESLMWALDEGILAGAGLDVLEGEELIQEESQLLTQPAVEDKLRAVLRQHLLARRENVVIT 306 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H AF + EA+ I T++N++ G N + Sbjct: 307 PHIAFYSTEAVHRIMDVTIENINAFLDGN-PQNVV 340 >UniRef50_B9L1V2 Glyoxylate reductase n=2 Tax=Thermomicrobia (class) RepID=B9L1V2_THERP Length = 333 Score = 372 bits (957), Expect = e-102, Method: Composition-based stats. Identities = 89/320 (27%), Positives = 147/320 (45%), Gaps = 23/320 (7%) Query: 13 KKYLQQVNESFGFELEFFD---FLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGV 69 ++ + + E G + + E+ + + + + + + + VL + + Sbjct: 25 REEIARFLEERGCRFVEKEIRYPVDEEQLCELVRDVDGLVVGL-EPITARVL--AHANRL 81 Query: 70 KYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRD 129 K I+ GF+N+D+ A G+ V + +VAE A G+M+ L R IHR+ + R+ Sbjct: 82 KVISTSGVGFDNIDVAEATRRGIVVANCHGANEHSVAELAFGLMLALARGIHRSDRLMRE 141 Query: 130 ANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEY 188 + G ++GKT GVIG G+ G A+ + +GFGMR+LA D A + Y Sbjct: 142 GRWE--PYFGVELWGKTLGVIGLGRAGRAVALLGRGFGMRVLAHDIVWDTTFANAHEISY 199 Query: 189 VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALK 248 V L L ESD +SLH PLTP+ +L++E A MK ++N +RG ++ A +EAL+ Sbjct: 200 VPLEKLLRESDFVSLHVPLTPDTRYLIDERALSLMKPTAFLINLARGPVVKQSALVEALR 259 Query: 249 NQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSIS 308 +I G+DV+E E NV+ T H T EA Sbjct: 260 RGQIAGAGLDVFEVEPIR--------------DNPFVEFENVVMTPHLGGSTEEARERTL 305 Query: 309 QTTLQNLSNLEKGETCPNEL 328 L N+ N+ G +++ Sbjct: 306 YLALTNVCNVLNGRPPHHQV 325 >UniRef50_B2IJN8 D-3-phosphoglycerate dehydrogenase n=6 Tax=Bacteria RepID=B2IJN8_BEII9 Length = 529 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 88/331 (26%), Positives = 148/331 (44%), Gaps = 20/331 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFL--LTEKTAKTANGCEAVCIFVNDDGSR 58 M V + + + + + G E++F L +K A+ + + I + Sbjct: 1 MAPRVLISDALSEAAV-AIFKERGIEVDFQPDLGKDKDKLAEIIGQFDGLAIRSATKVTD 59 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +LE+ +K + G +NVD+ AA G+ V+ P + AEHAI +M L R Sbjct: 60 KILEKA--TNLKVVGRAGIGVDNVDIPAATAKGVIVMNTPFGNSITTAEHAIALMFALAR 117 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 +I A T+ + G + K G+IG G IG + G MR++AFDP+ + Sbjct: 118 QIPSADASTQAGKWEKNKFMGVEITAKVLGIIGCGNIGSIVAERGVGLKMRVIAFDPFLT 177 Query: 179 AA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 AL+LGVE V+L L + +D I+LH PLTP+ ++L+ + K GV ++N +RG L Sbjct: 178 PERALDLGVEKVELDDLLARADFITLHTPLTPQTKNILSAENLAKTKKGVRVINCARGGL 237 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D +A + L + + DV+ E L NV+ T H Sbjct: 238 VDEEALRKLLDSGHVAGAAFDVFITEPAK--------------ENPLFGHPNVVCTPHLG 283 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T+EA +++ + +S+ N + Sbjct: 284 ASTSEAQENVALQVAEQMSDYLTRGAISNAV 314 >UniRef50_D2C7W6 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermotoga naphthophila RKU-10 RepID=D2C7W6_THENR Length = 329 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 90/333 (27%), Positives = 152/333 (45%), Gaps = 26/333 (7%) Query: 1 MKLAVYSTKQYDKKYLQQV--NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M+ V +T+ + + + + E GF + + E+ + EA+ + + +R Sbjct: 1 MRKVVVATRTFGRYTKEPIDYLERNGFVVLRVEK--EEELREAIKDAEALIVGTHT-VTR 57 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 ++E +K IA G +N+D++AA E G+ V + +VAE I + L+R Sbjct: 58 EMIE---SSNLKVIAKHGVGVDNIDVEAATEKGIPVTITLGANSLSVAELTIAFIFALSR 114 Query: 119 RIHRAYQRT-RDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 + A+ + + + G G + GK GVIG G IG +++ GM +L +DPY Sbjct: 115 GLIWAHNKLFYEKKWE--GYVGQEVSGKVMGVIGFGSIGREVVKKAVCLGMNVLVYDPYV 172 Query: 178 SAAALEL-GVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 S ++ L VD L L ESD +SLH PL +++ E MK ++NTSRG Sbjct: 173 SKDSVRLLEATPVDDLEQLLKESDFVSLHVPLNESTKNMIGERELSLMKKSAFLINTSRG 232 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D +A ++ALK +I +DV+ E D L C N++ T H Sbjct: 233 ELVDEEALVKALKEGRIAGAALDVFSEEPP-------------DANSPLFECPNLITTAH 279 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+ ++ Q++ + KG + Sbjct: 280 IGAHTKEAIFRMNMMAAQSIVDFFKGRIPRYVV 312 >UniRef50_B7KQC7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Methylobacterium extorquens group RepID=B7KQC7_METC4 Length = 335 Score = 371 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 161/328 (49%), Positives = 224/328 (68%), Gaps = 1/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++AV+S K Y++ L +N +L +FD LL TA A G AV +FVND +R V Sbjct: 1 MRVAVFSAKNYERALLDDLNVGQEHDLTYFDALLEPGTASLAAGFTAVSVFVNDSVNRDV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L +L + G K +A RC GFN++DL+AA+E G++VVRV Y P +VAE A+G+++ LNR++ Sbjct: 61 LRQLAQGGTKLVATRCTGFNHIDLEAAEEFGIRVVRVVNYSPNSVAEFAVGLLLALNRKV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 HRAY RTR+ NF L+GL GF + +T VIGTGKIG RI+ GFG R++ FD + S Sbjct: 121 HRAYNRTREGNFRLDGLMGFDLVDRTVAVIGTGKIGTIFGRIMAGFGCRVIGFDVHRSPE 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +G YVD + E+DVIS+HCPLTPE YH+++ ++K G +++NTSRG LID+ Sbjct: 181 FERIGGRYVDAAGV-EEADVISMHCPLTPETYHIVDARTLGRVKKGALLINTSRGGLIDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 AAI+ALK+ ++G L +DVYE E +LF+ D S+ VI DDV +RL + NV+ TGHQAF T Sbjct: 240 DAAIDALKSGRLGGLAIDVYEQEAELFYRDLSSTVIPDDVIQRLISFPNVIVTGHQAFFT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EAL +I TTL+++S LE G NE+ Sbjct: 300 QEALETILGTTLKSISELEAGHPLTNEV 327 >UniRef50_C5P2R3 D-lactate dehydrogenase, putative n=5 Tax=cellular organisms RepID=C5P2R3_COCP7 Length = 335 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 134/329 (40%), Positives = 194/329 (58%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++A +S ++K L+ N+ + EL FF L+E A G A+ FVND + Sbjct: 1 MRIAFFSILPHEKDALEAFNKEYHHELVFFKDSLSEANVALAAGFPAISAFVNDQLDSTI 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + L + G +ALRC+G++ VD+ AA G+ V RVPAY PEA+ E+ +GM++ L+RR Sbjct: 61 MRALAESGTMLVALRCSGYDRVDIKAATANGITVTRVPAYSPEAIVEYTVGMLIALDRRT 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 A+QR R NF L G G ++GKT G++GTG+IG + R+ K GF +LA D YP+A Sbjct: 121 PHAWQRVRAGNFDLTGFVGHGIHGKTVGIVGTGRIGAGVARVFKNGFHCEVLANDLYPNA 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + GV YV+ L SD++ LHCPLT H++ MK ++VNTSRGAL++ Sbjct: 181 TLEQDGVRYVEFKELLKSSDIVCLHCPLTTATRHIIKAETLAIMKQNAILVNTSRGALVN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S + AL+ +I +DV E E FF+ + DDV RRL + NV+ TGHQAFL Sbjct: 241 SSDLLHALEKGRIRGCALDVVEGEEKYFFQSSNQAKHIDDVLRRLISLPNVMITGHQAFL 300 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ SI++TTL+++ N E G N + Sbjct: 301 TRGAVDSIAKTTLKSIRNFESGTLKENVV 329 >UniRef50_O32264 Probable 2-ketogluconate reductase n=7 Tax=Bacillales RepID=TKRA_BACSU Length = 325 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 92/332 (27%), Positives = 151/332 (45%), Gaps = 22/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVND--DGSRP 59 K V+ TK ++ + E +E+ D L ++ + E + +R Sbjct: 3 KPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLKEAEGLLTSGTSGPSINRE 62 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE K +K ++ + G++N D++A KE G+ P + VA+ A ++++ RR Sbjct: 63 LLEHAPK--LKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTLDDTVADLAFSLILSSARR 120 Query: 120 IHRAYQRTRDANF---SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDP 175 + + R + E L G ++ +T G+IG G+IG R K GF M +L + Sbjct: 121 VAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIGEQAARRAKFGFDMEVLYHNR 180 Query: 176 YPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + + +GV+Y +L TL +SD I L PLT E YH++ E F+ MKN + VN SR Sbjct: 181 HRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETYHMIGEREFKLMKNSAIFVNISR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +D +A I AL+ I G+DVYE E L NV Sbjct: 241 GKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQ-------------DNPLLQLDNVTLLP 287 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 H TA+ ++ + +N+ +G+T N Sbjct: 288 HIGSATAKVRFNMCKQAAENMLAAIQGQTPKN 319 >UniRef50_C4DLZ3 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DLZ3_9ACTO Length = 324 Score = 370 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 85/332 (25%), Positives = 143/332 (43%), Gaps = 23/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFD----FLLTEKTAKTANGCEAVCIFVNDDGS 57 ++ V + + ++ G ++ A G + + D S Sbjct: 5 RVLVTTAWLSPGDEVHRLLTDAGCDVVHSSFNDRDSSPATLAALVTGFDGIVA-GTDRFS 63 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V+ + +K G++N+D+ AA E G+ V P + ++VAEH +++++ Sbjct: 64 AEVIAAADR--LKVFGRTGVGYDNIDVAAATERGIAVCPTPGVNRQSVAEHTFALLLSVA 121 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R + ++ ++G + G T G+IG G IG A+ RI GFGMR++A DPY Sbjct: 122 RGVPGNVTAVAAGDWP--QVSGRELSGATLGLIGLGAIGKAVARIALGFGMRVIAHDPYL 179 Query: 178 SAAALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A A+ GVE L L + +D +SLH L HL++ A MK G +VNTSRG Sbjct: 180 DAEAVAASGVERASLDELLATADFVSLHIFLDDATRHLIDAEAIATMKPGAYLVNTSRGG 239 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++D A AL+ ++ G+DV E E L N++ T H Sbjct: 240 VVDETALAAALREGRLSGAGLDVLETEPL-------------PPDSPLRGLDNLIITAHI 286 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E+ + Q + ++ G T + + Sbjct: 287 GAATVESRARSGRMAAQAVIDVLDGRTPEHVV 318 >UniRef50_Q0B0Y6 D-3-phosphoglycerate dehydrogenase n=9 Tax=Bacteria RepID=Q0B0Y6_SYNWW Length = 530 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 152/329 (46%), Gaps = 20/329 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + V +++ + ++ + E+++ D + E+ + + +A+ + ++ Sbjct: 3 RKKVIVSERIADEGIELLKTE--LEVDYRDGISREELLEIIDQYDALIVRSVTQVDEELI 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 K+ +K + G +N+D+D G+ V P + + AE I ++++ R Sbjct: 61 RRAKR--LKIVGRAGNGIDNIDVDVCTRYGVIVANTPDSNTISAAEQTISLLLSSIRNTA 118 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 A + + + + G +YGKT G++G G+IG + LK F MR++A+DPY S Sbjct: 119 WASEYLKGGTWDRKPFRGVELYGKTVGIVGLGRIGSMVATRLKAFNMRVIAYDPYISDER 178 Query: 181 ALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 G E + L L E+D I++H P E H+++E K GV +VN +RG +I Sbjct: 179 FTRFGAEKMESLEELVKEADFITVHTPRNEETMHMIDERILGLAKEGVRVVNCARGGIIK 238 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A ++ L+++K+ S G+DV+E E + L +V+ T H Sbjct: 239 EEALLKGLESKKVLSAGLDVFEKEPAI--------------DNPLFQFKSVVVTPHLGAD 284 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA + + + + KGE PN + Sbjct: 285 TFEAQKRVGENIAEQVIKALKGEIVPNLV 313 >UniRef50_Q5SZU1 Phosphoglycerate dehydrogenase n=11 Tax=Eutheria RepID=Q5SZU1_HUMAN Length = 499 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 77/289 (26%), Positives = 132/289 (45%), Gaps = 17/289 (5%) Query: 41 TANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAY 100 CE + + + V+ +K ++ + G +NVDL+AA G+ V+ P Sbjct: 10 LLQDCEGLIVRSATKVTADVINAAEK--LQVVGRAGTGVDNVDLEAATRKGILVMNTPNG 67 Query: 101 DPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAML 160 + + AE GM+M L R+I +A +D + + G + GKT G++G G+IG + Sbjct: 68 NSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIGREVA 127 Query: 161 RILKGFGMRLLAFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAA 219 ++ FGM+ + +DP S GV+ + L ++ D I++H PL P LLN+ Sbjct: 128 TRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCDFITVHTPLLPSTTGLLNDNT 187 Query: 220 FEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDD 279 F Q K GV +VN +RG ++D A + AL++ + +DV+ E Sbjct: 188 FAQCKKGVRVVNCARGGIVDEGALLRALQSGQCAGAALDVFTEEPPR------------- 234 Query: 280 VFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 R L NV+ H T EA + + ++ KG++ + Sbjct: 235 -DRALVDHENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLTGVV 282 >UniRef50_C5EL38 D-3-phosphoglycerate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EL38_9FIRM Length = 311 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 96/314 (30%), Positives = 153/314 (48%), Gaps = 16/314 (5%) Query: 14 KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIA 73 ++ ++ GF++ L + + GC+A I D ++ +E LK + IA Sbjct: 10 DAFEERLKAAGFQVVRTGERLPAQIIECGKGCQAAVINAEDQWTKETMEGLKDT-LGLIA 68 Query: 74 LRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFS 133 G +NVDLDAA+ LG+KV + E+VAE A+ +M+ RRI + RD + Sbjct: 69 RFGVGLDNVDLDAARGLGIKVANSAGANKESVAECAVTLMLECTRRISWLDGKLRDGQW- 127 Query: 134 LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALELGVEYVDLP 192 GKT G+IG G I + + KGFG ++LA D + AA L + ++ Sbjct: 128 KGLPRTHQFSGKTVGLIGFGAIAQCVAGMAKGFGCKVLACDVIKNETAAKRLDTVFCEMD 187 Query: 193 TLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKI 252 L +SD ISLH PLT + H+++EA ++MK +++NTSRG ++D +A ALK I Sbjct: 188 ELLEKSDFISLHVPLTEDTRHMVSEAFLKKMKPTAILINTSRGPVVDEKALYRALKEGWI 247 Query: 253 GSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTL 312 + G+DV+E E L HN++ T H A T EA +I+ + Sbjct: 248 QAAGLDVFEQEPPGG-------------DNPLFGLHNIIVTPHAASSTEEAAGNIADLCM 294 Query: 313 QNLSNLEKGETCPN 326 +N+ + + Sbjct: 295 ENICSYFETGIPKY 308 >UniRef50_B6KF90 D-3-phosphoglycerate dehydrogenase, putative n=3 Tax=Toxoplasma gondii RepID=B6KF90_TOXGO Length = 604 Score = 369 bits (948), Expect = e-100, Method: Composition-based stats. Identities = 81/325 (24%), Positives = 144/325 (44%), Gaps = 13/325 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V D+ + ++ ++ L E+ + + + + + +++ Sbjct: 18 VLVCDPIDQAGMDILSSFAD--VDTKLKLSEEELCRVVGNYDGLMVRSGTTVTEKIIKHG 75 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K +K I G +NV +DAA G+ VV P + A AE +G+MM L R+I +A Sbjct: 76 QK--LKIIGRAGVGVDNVCVDAATAQGIFVVNSPNGNTMAAAELTLGLMMALARKIPQAD 133 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 ++ G + KT G+IG G++G + R+ GM +LA+DP+ + A Sbjct: 134 ASVSRGEWTRSKFMGRQLNQKTIGIIGLGQVGTHVARVCTALGMEVLAYDPFINEEKAKA 193 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 +G V L TL + SD I+LH PL + HL+N + +K I+N SRG +ID +A Sbjct: 194 VGCRNVALETLLASSDFITLHVPLLDKTRHLINADKLKLIKKDACIINASRGGVIDEKAV 253 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 EAL ++ +DV+E E++ ++ + N++ T H T EA Sbjct: 254 AEALMANELAGAALDVFEEEKEFSKDNPLIQAKANGR--------NIILTPHIGASTLEA 305 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 +++ G + + Sbjct: 306 QHNVAVDVALQFREALLGGLPQSAV 330 >UniRef50_C0CRA6 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=C0CRA6_9FIRM Length = 321 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 108/334 (32%), Positives = 168/334 (50%), Gaps = 25/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGF--ELEFFDF---LLTEKTAKTANGCEAVCIFVNDD 55 MK+ V T + + + F EL F D L E+ GC+ + D Sbjct: 3 MKILVTPTSLQPGRKSKALERLRDFSEELVFNDKSRPLTEEELIPLLKGCQGYLAGL-DF 61 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 + VL E + +K I+ G++ +D+ AA + G+ V P + +AV E A G++++ Sbjct: 62 ITERVLREAED--LKVISRYGTGYDRIDMAAASQYGVTVTNTPGVNAQAVGELAFGLLLS 119 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + R+I + TR + G + GKT G++G G IG + R KGFGMR+ A DP Sbjct: 120 VARQISYLDRTTRSGEWVRAE--GVELKGKTLGILGLGAIGKVVARCAKGFGMRVAASDP 177 Query: 176 YPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + E G+E +D+ L S +D +SLH PL E HL+ + A +MK+GV+++NTSR Sbjct: 178 FIDREYCREHGIEAMDMEDLLSFADAVSLHLPLNKETTHLIGKEALARMKDGVILINTSR 237 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +ID +AA LK+ KIG LG+D +ENE L NV+ T Sbjct: 238 GGIIDEEAAYCGLKSGKIGGLGLDAFENEPPKG--------------SSLFEFSNVVATP 283 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T EA + +++ + NL ++ +GE CP + Sbjct: 284 HTGAHTKEAASMMAERAVDNLISVLQGERCPYIV 317 >UniRef50_A7SFV8 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7SFV8_NEMVE Length = 487 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 75/325 (23%), Positives = 140/325 (43%), Gaps = 16/325 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + D + + E G ++ L E+ + + + S V++ Sbjct: 9 VLISDSVD-SCCKTILERNGVTVDVNTKLSKEELVSEIPKYDGLIVRSATKVSEDVIKAG 67 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K +K I G +N+D AA G+ V+ P + + AEH ++ +L R I +A Sbjct: 68 K--NLKIIGRAGTGVDNIDTVAASLHGVLVMNTPGGNTLSAAEHTCALISSLARHIPQAS 125 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA-AALE 183 T++ + + G ++GKT +IG G+IG + ++ +G++ + +DP S A E Sbjct: 126 ASTKEGKWERKQFMGNELFGKTLAIIGLGRIGREVALRMQSYGVKTIGYDPLVSPQDAAE 185 Query: 184 LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 +E+++ ++ +D I++H PL P +LN+ K GV I+N +RG +ID +A Sbjct: 186 SNIEWMETEKIWPLADYITVHVPLIPPTKGMLNDKTIGMCKKGVYILNVARGGIIDEEAL 245 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 + L++ +G G+DV+ E L V+ H T EA Sbjct: 246 LRGLESGHVGGAGLDVFVTEPPTGSSAD------------LVKHPKVIACPHLGASTEEA 293 Query: 304 LTSISQTTLQNLSNLEKGETCPNEL 328 ++Q + G+ + Sbjct: 294 QRRVAQEIADQFVDGMNGKPLIGLV 318 >UniRef50_D2R855 D-3-phosphoglycerate dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R855_9PLAN Length = 542 Score = 367 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 145/326 (44%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + ++ L + + G E E L E+ K+ + + LE Sbjct: 4 ILILDPIAQEGLDMLAAAPGIEYEVRTGLKGEELKKSLAEFDGAICRSGVTITAESLE-- 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ IA G +N+D +AA LG+ V+ P + + AEH +M+ L+RR+ AY Sbjct: 62 GNRRMRAIARAGVGTDNIDKNAATRLGIVVMNTPTGNTLSTAEHTFTLMLALSRRVAEAY 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS-AAALE 183 + + + G + KT G++G G+IG + + F M++L FDP+ S A + Sbjct: 122 HKLIGGKWDRKTFMGTQLADKTLGIVGLGRIGQEVAKRAIAFQMKVLGFDPFLSTEQAAK 181 Query: 184 LGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 LG+E V+ + + D +++H PLTPE +L+ E +K GV ++N +RG + + A Sbjct: 182 LGIERVETVQEMLPRVDYLTVHTPLTPETTNLVGFPELEVLKPGVRLINCARGGIYNEDA 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +E LK KIG + +DV+ E + NVL T H T E Sbjct: 242 LVEGLKTGKIGGVALDVFVTEPCDK--------------HPIYGMPNVLCTPHLGASTEE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A ++ +Q L N + + Sbjct: 288 AQQQVAIEAVQLLINFFTTGEVRHAV 313 >UniRef50_C0QYX0 D-3-phosphoglycerate dehydrogenase n=2 Tax=Brachyspira RepID=C0QYX0_BRAHW Length = 534 Score = 366 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 83/328 (25%), Positives = 154/328 (46%), Gaps = 17/328 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V T + ++ + + E F + ++ K +A+ + +R ++E Sbjct: 1 MKVLITDKVNECVKDIIADVS--EAVFLPTMSEDELVKVIGEYDALMVRSQTKVTRKIIE 58 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K I G +N+D++AA E G+ VV P + A +EH I +M+ ++R I Sbjct: 59 AGK--NLKIIGRAGVGVDNIDVEAATEKGIIVVNSPDGNTIAASEHTIALMLAVSRNIVP 116 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A T++A ++ + TG + GKT GV+G G+IG ++ I GM+++ +DP+ + Sbjct: 117 AAVSTKEAKWNRDKFTGNELLGKTLGVMGFGRIGRKVVHIALAIGMKVIVYDPFATEEIV 176 Query: 182 LELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + G Y L + D +SLH P TPE +++N+ +MKN +I+N SRG L++ Sbjct: 177 QKAGAVYETSLDEFLPKLDYLSLHIPKTPETNNIINKDNLCKMKNTAIIINCSRGGLVNE 236 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + AL+N I + +DV+ NE + N++ T H T Sbjct: 237 EDLKNALENGTIAAAAVDVFVNEPKIETCPLVE-----------YKKDNLILTPHLGAST 285 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ + + + G + + Sbjct: 286 KEAQINVALDVAKQIKQVLSGGYTESAV 313 >UniRef50_D1U9G1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfovibrio RepID=D1U9G1_9DELT Length = 343 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 86/334 (25%), Positives = 141/334 (42%), Gaps = 23/334 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFL-LTEKTAKTANGCEAVCIFVNDDGSRPV 60 K ++ T++ + + E + D + + C+ V + + Sbjct: 3 KPKIFITRRIPDAGIDMLAEVAEVVVNPEDRTLSRAELLASVADCQGVIGLLTEKIDAEF 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + K +K A G++N+D+ A + V P +A AE A ++ RR+ Sbjct: 63 FDAAPK--LKGYANYAVGYDNIDVAEATRRSIPVSNTPGVLTDATAECAWALIFATARRV 120 Query: 121 HRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD--- 174 A + R + G G + GKT G++G G+IG AM + +GF MR+L Sbjct: 121 AEADRVMRSGAWQGWGPLQFIGQGVRGKTLGIVGAGRIGTAMALMSRGFDMRVLYTSSSG 180 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + L V TL +E+D IS+H PLTP+ HL + AAF +MK IVNT+R Sbjct: 181 RRNAVLEDTLKARLVPFDTLLAEADFISIHTPLTPDTRHLFDAAAFGRMKRTACIVNTAR 240 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +I ++ALKN I G+DV+E E + L+ N + Sbjct: 241 GPVIKEDDLVDALKNGVIAGAGLDVFEREPAMAPG--------------LAGLDNAVVLP 286 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E+ T ++ +N+ + G+ L Sbjct: 287 HIGSATVESRTDMATLAARNMLAMLAGQRPETCL 320 >UniRef50_B3T9W6 Putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein n=1 Tax=uncultured marine microorganism HF4000_APKG7H23 RepID=B3T9W6_9ZZZZ Length = 491 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 87/290 (30%), Positives = 137/290 (47%), Gaps = 17/290 (5%) Query: 40 KTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA 99 + G EA+ + + ++E ++ I G +NVDLDAA G+ VV P Sbjct: 3 EIIGGYEALIVRSETQVTAGLIEAGGH--LQVIGRAGVGVDNVDLDAATRQGIPVVNAPT 60 Query: 100 YDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAM 159 + A AEH + +M+ + R I +A R + G + GK G+IG GK+G + Sbjct: 61 GNTVAAAEHTLALMLAMVRHIPQADASVRMGEWRRSAFMGVEVRGKILGIIGLGKVGSEV 120 Query: 160 LRILKGFGMRLLAFDPY-PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEA 218 R + MR+LA DP+ P +A LGVE V L L +E+D I++H PLT LL A Sbjct: 121 ARRTRALQMRILAHDPFVPQESARSLGVEMVSLDQLMAEADFITIHTPLTATTQQLLGPA 180 Query: 219 AFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQD 278 F+Q+K+GV I+N +RG L++ Q +EAL++ ++ +DV+ E Sbjct: 181 QFQQLKHGVRIINAARGGLVNEQLLLEALESGRVAGAALDVFVEEPPKQ----------- 229 Query: 279 DVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 L V+ T H T EA T ++ + + G + + Sbjct: 230 ---SPLLQHPRVVLTPHLGASTEEAQTEVALEIADQVLAVLAGSSAQYTV 276 >UniRef50_A0Q365 D-isomer specific 2-hydroxyacid dehydrogenases n=11 Tax=Bacteria RepID=A0Q365_CLONN Length = 317 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 95/332 (28%), Positives = 159/332 (47%), Gaps = 22/332 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNE---SFGFELEFFDFLLTEK--TAKTANGCEAVCIFVNDD 55 M+++V K+ + + + G E+ F+ + +K + A E V + N Sbjct: 1 MRISVLEPLGLPKEEVYSIAKPIIDKGHEVILFEDKVQDKKVLMERAKDAE-VLVLANMP 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V++ +K I++ G ++VD A E + V Y +VAE G++ + Sbjct: 60 LEGEVIKS--DDKLKMISVAFTGIDHVDTKACTEKQVMVCNAAGYSTSSVAELTYGLIFS 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + R I + TR+ + G + + GKT G++GTG IG+ + +I K FG +LA+ Sbjct: 118 VLRNIVPLDKATREGK-TRNGFSQNEILGKTIGIVGTGAIGIRVGQIAKAFGCNVLAYSR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A++ G +YV L L S+SD++SLH PL E L+++ E MK+ +++NT+RG Sbjct: 177 SERKEAIDTGFKYVSLDELLSKSDIVSLHVPLNDETKGLISKEKIELMKSSSILINTARG 236 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D+ A EALK KI G+DV+E E + E L NV+ T H Sbjct: 237 PVVDNSALAEALKKGKIKGAGIDVFEIEPPISKE------------HPLFNAPNVVVTPH 284 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNE 327 AF T EA+ + +N+ G + N Sbjct: 285 IAFATEEAMYRRCEIVFKNIEKWLDG-SPQNV 315 >UniRef50_C0WBM0 D-3-phosphoglycerate dehydrogenase n=1 Tax=Acidaminococcus sp. D21 RepID=C0WBM0_9FIRM Length = 529 Score = 365 bits (939), Expect = 1e-99, Method: Composition-based stats. Identities = 89/329 (27%), Positives = 152/329 (46%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V ++ K + + ++ + E + +A+ + + + Sbjct: 3 KQKVLVAERISDKGVVCLKAEKALDVTVDFDIKREDLLQVIGNYDALIVRSVTKVNEELY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + KK +K I G +N+DLD A + G+ VV P + + AEH IG+++ R Sbjct: 63 DAAKK--LKVIGRAGNGVDNIDLDGATKRGIIVVNTPEANIISAAEHTIGLLLASCRNTV 120 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAA 180 RA + + + + L G +Y KT G+IG G+IG + + + F MR++A+DPY P + Sbjct: 121 RANKMLEEGIWERKDLKGSELYHKTLGIIGLGRIGALVTKRMHAFDMRVIAYDPYIPDSR 180 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 LGVE + L L E+DVI++H P T E ++L A +++ K GV +VN +RG L + Sbjct: 181 FQRLGVEKCETLDDLLKEADVITIHTPKTEETVNMLGAAEWKKCKKGVRVVNCARGGLYN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 Q EA+K + S+G+DV +E + L + T H Sbjct: 241 EQDLAEAVKEGIVASVGLDVVVDEP--------------NPISPLIGMPQCVVTPHLGAS 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA + + + N+ G+ PN + Sbjct: 287 TFEAQDKVGLAIAEEVINVLGGKMVPNAV 315 >UniRef50_B0P693 Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0P693_9FIRM Length = 322 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 157/329 (47%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + +++ G EL + ++ A C+A+ + V+ Sbjct: 5 KVVISDYYYESIAQEREIIRQAGGELFDYHCATEDEVISAAADCDALIC-QFAPITARVI 63 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + + K I G +N+DL AA+E G+ V VP Y + V+ HAI ++M +++ Sbjct: 64 RAMPR--CKVIVRYAIGVDNIDLKAAEEQGVYVCNVPDYSIDEVSNHAIALLMDCVKKLT 121 Query: 122 RAYQRTRDANFSLEGLTG-FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA- 179 + + S + M G T G++G G+I + + + GFG++++A+DP Sbjct: 122 FLASQVKAGRSSYTVVKPLHRMQGSTLGLMGFGRIPRLVAQKMAGFGLKMIAYDPMLDQQ 181 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 AA ELGV V L +SD +S+HCPL H+ N+ AF MK ++VNT+RGA++D Sbjct: 182 AAQELGVTPVSFEQLLMDSDYLSIHCPLNESTRHIFNQEAFRLMKPTAVLVNTARGAVVD 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 QA I+AL + +I G+DV E E L N + T H A+ Sbjct: 242 EQALIQALSDGQIAMAGLDVTEQEPVA-------------ADNPLLKLDNAVVTPHAAWY 288 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 + EA+ S+ + + ++ + +GET N + Sbjct: 289 SEEAVASLQRKVAEEVARVLRGETPQNPV 317 >UniRef50_UPI0001C31769 D-3-phosphoglycerate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31769 Length = 541 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 89/329 (27%), Positives = 146/329 (44%), Gaps = 19/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 +L + ++ + + E F+++ E+ + I + + Sbjct: 7 RLKILVKEKLADSGVDLLREH--FDVDLGADWSDEEFRSRLPEYHGILIRSATKLTEEYI 64 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 ++ I G NNVD+ AA G+ V P + AEH + ++++L R + Sbjct: 65 ALG--TNLRVIGRAGVGVNNVDVPAATRRGIVVANAPQSNVVTAAEHTMALLLSLARNVP 122 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 +A++ D + G +Y KT GV+G G+IG + KGFGM+++AFDP+ A Sbjct: 123 QAHRSLTDHRWERSKFGGVEVYEKTLGVVGFGRIGQLVAERAKGFGMKVVAFDPFVGAER 182 Query: 182 -LELGVEYVDL-PTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +LGVE D ++ +D I++H P+TPE LN AF QMK+GV IVN +RG L+D Sbjct: 183 YRDLGVEKADTSADVYKVADFITIHLPVTPETQGWLNAEAFAQMKDGVRIVNCARGELVD 242 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A +AL + K+ +DV+ +E + NV+ T H Sbjct: 243 DAALKDALDSGKVAGAALDVFPSEPITDYPLFDGYA-------------NVVVTPHLGAS 289 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAEA T + + G T + Sbjct: 290 TAEAQDRAGVQTAEQVIAALTGGTVTTAV 318 >UniRef50_B1KZ88 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=29 Tax=Clostridiaceae RepID=B1KZ88_CLOBM Length = 314 Score = 364 bits (937), Expect = 2e-99, Method: Composition-based stats. Identities = 85/318 (26%), Positives = 140/318 (44%), Gaps = 17/318 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + + +K L ++NE + E+ +A+ I + +++ Sbjct: 2 IKILVSDGMEKNALNKLNEQGF--VVLDKHFEKEELKDKIKDFDAIIIRSATKVDKEIID 59 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K + G +NVDL+ AKE G+KV P +VAE +G M+ ++R I+ Sbjct: 60 AGIKGNLKLVVRAGVGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINT 119 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A + + G +YGKT G+IG G+I + + GM ++ +D Sbjct: 120 ANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEEY 179 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E + L L + SD IS+H P + LL E F +MK+GV IVN +RG +I+ +A Sbjct: 180 EE-FKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIVNCARGGVIEEEA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 ++AL N K+ + +DV+ENE + + L V T H T E Sbjct: 239 LLKALNNGKVTAAALDVFENEP--------------EPKKELINHERVSITPHIGASTKE 284 Query: 303 ALTSISQTTLQNLSNLEK 320 A I + + L N Sbjct: 285 AQMRIGEEIVDILDNFFN 302 >UniRef50_A8A9G4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=3 Tax=Archaea RepID=A8A9G4_IGNH4 Length = 308 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 100/316 (31%), Positives = 154/316 (48%), Gaps = 17/316 (5%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK 65 T + L+ + E +E + E + G + + + R V+E Sbjct: 5 LVTDKVHPAGLELLREKGIEVVEDLEAYKPEVLKERIKGFDVLIVRSRTKVRREVIEAAD 64 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 K +K IA +G +N+DL+AAKE G+KVV P AVAE IGMM+ L RR H +Y+ Sbjct: 65 K--LKVIARAGSGLDNIDLEAAKEKGIKVVNAPDALKNAVAELVIGMMVVLARRAHYSYR 122 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALEL 184 + + + + GF + GKT GV+G G+IG + + K GM ++A+D S A E+ Sbjct: 123 KLLEGEWEK--VMGFELAGKTLGVVGFGRIGREVAKKAKALGMNVIAYDVVDLSETAKEM 180 Query: 185 GVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAA 243 GVE+ DL L +SDV+SLH PLT + +++N + MK+G +++N +RG + D A Sbjct: 181 GVEFTQDLEELLRKSDVVSLHVPLTEQTRNMINRDRIKIMKDGAILINAARGEVADYSAL 240 Query: 244 IEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEA 303 +EAL++ K+ +G+DVY E E +L T H T EA Sbjct: 241 LEALESGKLWGVGLDVYPEEPPKSEE-----------LLKLIRHPRTFATAHIGAQTEEA 289 Query: 304 LTSISQTTLQNLSNLE 319 S Q + Sbjct: 290 QRRTSLEVAQRILEAL 305 >UniRef50_C2D1B3 D-3-phosphoglycerate dehydrogenase n=6 Tax=Lactobacillus RepID=C2D1B3_LACBR Length = 327 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 142/329 (43%), Gaps = 21/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V K + ++ G ++ D T+ + + + IF+ D V Sbjct: 14 MSKKVVVPKSLSEDG-KKFLTDRGIDIIEVDGNFTDGLLEHGRDADGMIIFL-DHVGEAV 71 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L ++ +K IA G++++DLDA+ + G+ V P + VAE + + L++ + Sbjct: 72 LSQMP--NLKIIARHGVGYDSIDLDASAQHGVWVTNTPNANAATVAETTLAEIFDLSKNV 129 Query: 121 HRAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +A R N++ GF + GKT G+IG G IG + + M +L ++ Sbjct: 130 TKASSEMRKGNYTYALAHRGFDLAGKTLGIIGYGHIGQQVAKKASALDMPILIYNRSKKE 189 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++VDL TL +D+++LH P +H++ + +MK +++N RG LID Sbjct: 190 ---SPYGKFVDLDTLLKTADIVTLHLASNPATHHIIGKDQLAEMKRSSVLINLGRGGLID 246 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + A I ALK +I +DV+E E + L NVL T H Sbjct: 247 TSALINALKTHQIAGAALDVFEEEPL-------------PLDSDLFQFDNVLLTPHIGSS 293 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E+ + ++ + + GE + Sbjct: 294 TVESFSRMAVDAASEVVRVLNGEKPQWPV 322 >UniRef50_A9KPU0 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KPU0_CLOPH Length = 316 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 80/331 (24%), Positives = 142/331 (42%), Gaps = 19/331 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + D+ + + G+EL E C + + ++ V Sbjct: 1 MKQIILIPQDVDESG-KNYLQEKGYELRILQDSSIENICNNIGDCSGLLLR-TVPCTKEV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + +K I G++N+D+ A G+KV P + +VAEH I +++ + I Sbjct: 59 FDAAPH--LKVIGRHGVGYDNIDIAEATAQGIKVCYTPLANANSVAEHTIMLLLACAKNI 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 A + R N+ + G ++GKT G+IG G+IG ++ + G GM++LA+ Sbjct: 117 VIADKELRQGNYEIRNQMPGIDVFGKTLGIIGFGRIGKSVAKKAALGLGMKILAYGRGLE 176 Query: 179 AAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + V + ++ L +SD ISLH P + E ++ MK +++NT+RG + Sbjct: 177 IKEVPDYVTIIKEVDELIRQSDFISLHMPYSKEMQGFMDSTKLSLMKPEAVLINTARGGI 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ++ AL N KI G+DV+ +E + L NV+ T H A Sbjct: 237 VNEDDLYHALINHKIAGAGLDVFIDEPFK------------ETLSNLFQLDNVVVTPHSA 284 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 LT EA+ +S + + G+ + Sbjct: 285 ALTKEAMARMSLDAAIGIDEVLSGKKPSWPV 315 >UniRef50_B6H0R3 Pc12g10550 protein n=23 Tax=Fungi/Metazoa group RepID=B6H0R3_PENCW Length = 596 Score = 363 bits (932), Expect = 7e-99, Method: Composition-based stats. Identities = 84/329 (25%), Positives = 148/329 (44%), Gaps = 16/329 (4%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + V ++ L + S ++ L ++ + +A+ + + VL Sbjct: 8 RPKVLVPEKLSPDGLALLRSS--LDVHERKGLSADELLQIIPDYDALLVRSETKVTATVL 65 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 K +K +A G +NVD++ A +LG+ VV P+ + A AEH I +MM++ R+I Sbjct: 66 RAAK--NLKVVARAGVGVDNVDVEEATKLGIVVVNSPSGNIGAAAEHTIALMMSMARKIP 123 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY--PSA 179 + +D + G + GKT +IG GK+G+ + R+ KG GM + A DPY P+ Sbjct: 124 ESCASLKDGKWERSKFVGVEVKGKTLSIIGLGKVGLTVARLAKGLGMNVNALDPYASPAV 183 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 AA LP L + +D +++H PL ++ EA Q+K G ++N +RG D Sbjct: 184 AASASVALVSSLPELLASADFLTIHTPLIASTRGMIAEAELAQLKPGARVLNVARGGTFD 243 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A + AL++ + +DV+ +E D RL A + T H Sbjct: 244 EDALLAALESGHLSGAAIDVFTSEPPA----------PDSSAARLIAHPRAVVTPHLGAS 293 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++S + + + +G + + Sbjct: 294 TVEAQENVSVDVCEQVLEILQGSLPRSAV 322 >UniRef50_O66939 D-lactate dehydrogenase n=1 Tax=Aquifex aeolicus RepID=O66939_AQUAE Length = 334 Score = 363 bits (932), Expect = 7e-99, Method: Composition-based stats. Identities = 105/324 (32%), Positives = 166/324 (51%), Gaps = 7/324 (2%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + S Q D + Q+ + ++ D + E + +FV D + + Sbjct: 1 MNVLFTSVPQEDVPFYQEALKDLSLKIYTTDVSKVPEN--ELKKAELISVFVYDKLTEEL 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L ++ + +K I R GF+++DLD K+ G+ V +PAY PE+VAEH M++TL +R+ Sbjct: 59 LSKMPR--LKLIHTRSVGFDHIDLDYCKKKGILVTHIPAYSPESVAEHTFAMILTLVKRL 116 Query: 121 HRAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 R R + NFS + + + T GVIGTG+IG + FGM++L +D Sbjct: 117 KRIEDRVKKLNFSQDSEILARELNRLTLGVIGTGRIGSRVAMYGLAFGMKVLCYDVVKRE 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E G Y L L ESDVISLH P T E +H++NE MK+GV ++NT+RG ++D Sbjct: 177 DLKEKGCVYTSLDELLKESDVISLHVPYTKETHHMINEERISLMKDGVYLINTARGKVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFR--RLSACHNVLFTGHQA 297 + A A + K LG+DV+E+E L + + D + L+ NV+ T H A Sbjct: 237 TDALYRAYQRGKFSGLGLDVFEDEEILILKKYTEGKATDKNLKILELACKDNVIITPHIA 296 Query: 298 FLTAEALTSISQTTLQNLSNLEKG 321 + T ++L I + T++ + KG Sbjct: 297 YYTDKSLERIREETVKVVKAFVKG 320 >UniRef50_C0DAP4 Putative uncharacterized protein n=3 Tax=Clostridium RepID=C0DAP4_9CLOT Length = 320 Score = 363 bits (932), Expect = 7e-99, Method: Composition-based stats. Identities = 93/330 (28%), Positives = 152/330 (46%), Gaps = 18/330 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + + +++ E GFEL + +A+ D R V Sbjct: 1 MRVVITDYQYDNVDAERRLVEGAGFELLDYQVKTPGALIPLVKDADAII-TQYADIDRQV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E L+ K I G NN+D AA E G+ V VP Y V++ A+ M++ L +++ Sbjct: 60 IESLEH--CKMIIKYGIGVNNIDCRAAGEKGIYVCNVPDYGVHEVSDQAVTMILCLGKKL 117 Query: 121 HRAYQRTRDANFSLEGLTGF-TMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + R + G+ AG+IG G+I + R L+ FGM +L +DP+ Sbjct: 118 EPLQEDLRRGKWGYGGIVPVKRFTECKAGLIGFGRIPQMVCRKLQAFGMEILVYDPFVDD 177 Query: 180 AALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A +E G + + +D IS+HCPLT E H++ E F MK IVNT+RG ++ Sbjct: 178 AVIEAAGAVRASVEEICRNADFISVHCPLTEETRHMIGEKEFAMMKPECCIVNTARGGVV 237 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D QA I AL +I G+DV+E E V+ L NV+ T H A+ Sbjct: 238 DEQALIGALNEGRIAGAGVDVFEEEPVS-------------VYHPLLHMENVIATPHSAW 284 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + A+T++ + + + N+ +G N + Sbjct: 285 YSETAITTLQRKAAEEVVNVLQGNEPMNCV 314 >UniRef50_Q04AA8 Lactate dehydrogenase related enzyme n=3 Tax=Firmicutes RepID=Q04AA8_LACDB Length = 316 Score = 362 bits (930), Expect = 1e-98, Method: Composition-based stats. Identities = 94/333 (28%), Positives = 162/333 (48%), Gaps = 22/333 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNES---FGFELEFFDF--LLTEKTAKTANGCEAVCIFVNDD 55 MK+ + ++ L ++ E G E +D TE+ K + +A+ I + Sbjct: 1 MKIVLLEPLGISQESLDKLAEKLTKQGHEFTAYDSFSTDTEELKKRSEDADALIIANHL- 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V+ +K+I++ G ++VDL+A KE + + Y +AVAE AIG+ + Sbjct: 60 LPGEVIRA--DKNLKFISVAFVGIDHVDLEACKEKKINISNTGGYCNDAVAELAIGLTLD 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R+I + + GL G + GKT G++GTG IG I K FG +L+ + Sbjct: 118 CLRKISAGNEAVQAGE-GKGGLQGHELAGKTVGIVGTGAIGCRTAEIFKAFGCKLIGYSR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 AAAL+LG+EY L + E+D++S+H PLTPE L+ + +MK G +++NT+RG Sbjct: 177 SQKAAALDLGLEYKSLDEVMGEADIVSIHTPLTPETKGLIGKKEIGEMKEGAILINTARG 236 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++D++A ALK +I G+DV++ + L L N++ + H Sbjct: 237 PVVDTEALAAALKEGRIK-AGLDVFDQDPPL------------PADYPLLGVPNLVCSPH 283 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T E++ ++ +N++ G+ L Sbjct: 284 VGFDTKESIDRRAEMAFENVTAWLNGQQIRTML 316 >UniRef50_A7VV70 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VV70_9CLOT Length = 316 Score = 362 bits (930), Expect = 1e-98, Method: Composition-based stats. Identities = 92/335 (27%), Positives = 137/335 (40%), Gaps = 27/335 (8%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V + + L + E G EL + E+ + A E + I S Sbjct: 1 MKIVVLDGETTNPGDLSWERLEKLG-ELTVYARTKPEELYERAKEAE-LLITNKTVLSGK 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 ++ LK +KYI GFN VD+ AA++LG+ V VP+Y AVA+ ++ L Sbjct: 59 MIRSLK--NLKYIGTLSTGFNVVDIHAARKLGIPVCNVPSYCTNAVAQMTFSLLFALTNH 116 Query: 120 IHRAYQRTRDANFS------LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + ++ + K GV G G IG + +I GM +L + Sbjct: 117 VALHNHSVHQGDWENSTDFCYWKAPLVELESKNFGVYGFGSIGRTVAKIAADLGMNVLVY 176 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + G +V LF ESDV+SLHCPLTPE L+N MK ++NTS Sbjct: 177 SRTKKD--MPSGYRWVSQEELFRESDVLSLHCPLTPETTGLVNRKTLSLMKPTAYLINTS 234 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +I Q EAL ++ MDV E L+ C + T Sbjct: 235 RGQVIREQDLAEALNGGRLAGAAMDVLCEEPPEKGN-------------PLTHCEKCVIT 281 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H ++ E+ + T N+ KG T N++ Sbjct: 282 PHISWAAKESRDRLLHTVCDNVEAFLKG-TPQNQV 315 >UniRef50_B8I0H1 D-3-phosphoglycerate dehydrogenase n=13 Tax=Clostridia RepID=B8I0H1_CLOCE Length = 535 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 157/327 (48%), Gaps = 13/327 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V T++ + + + G E++ + E+ +T +A+ + + + Sbjct: 1 MKIIV--TERIAEDGIN-YLKENGHEVDTRYGISHEELLETIEDYDAIIVRSVTKVNEEL 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ K +K G +N+++ A + G+ VV P + A AE A+G + R I Sbjct: 58 LQRASK--LKVAGRAGNGIDNIEVPACTKRGIIVVNTPESNIMAAAELAVGHAYAIFRNI 115 Query: 121 HRAYQRTR-DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +A+ + +F G + KTAG+IG G+IG + LKG M+++A+DPY + Sbjct: 116 PQAHWAGKAQNDFRRSRFNGNELDEKTAGIIGLGRIGSIVATKLKGSNMKVIAYDPYITD 175 Query: 180 AA-LELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +LGVE D L L +SD+ISLH P T E Y ++ E + K V IVN +RG L Sbjct: 176 EKFKKLGVERCDTLEELLKQSDLISLHTPKTSETYGMIGEEQLKLCKKDVRIVNAARGGL 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ++ +A A+K + + +DV + E + + + D +L NV+ T H Sbjct: 236 VNEEALYNAIKEGHVAAAALDVLDPEPNYDKKPE-----DQDYQNKLFELDNVIITPHLG 290 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETC 324 TAEA ++ + +S+ KGE Sbjct: 291 ASTAEANYNVGTAVSKLVSDALKGEMV 317 >UniRef50_UPI0001BC4ADC hypothetical protein FulcA4_06865 n=1 Tax=Fusobacterium ulcerans ATCC 49185 RepID=UPI0001BC4ADC Length = 319 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 92/330 (27%), Positives = 153/330 (46%), Gaps = 19/330 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V + K+ ++ + +S+GFE++ E K C+A+ + + V Sbjct: 1 MSHKVLIPQAVAKEGVE-LLKSYGFEIKHGSGASEEDLIKDVADCDAILLR-TAPCTEAV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ K +K +A AG+NNVDL+AA +LG+ P VAE +G ++ +++RI Sbjct: 59 LKAGK--NLKIVARHGAGYNNVDLEAAAKLGIWATNAPDSTTNTVAEFVLGAILAVSKRI 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPS 178 ++ ++ +F G + GK GV+G G+IG + G GM +LA+DP+ + Sbjct: 117 FLMNKKIKEGDFFFKNNHKGMDLTGKKLGVVGFGRIGRKVAYKAFYGLGMEILAYDPFLT 176 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 V D T+F ESD+ISLH PL EN + + F MK +N +RG ++ Sbjct: 177 KENCPDYVTICDWETIFKESDIISLHMPLIKENIGCVGKKEFTNMKKSAHFINCARGEVV 236 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 + + IEALK ++I +DV+E E L L + NV+ T H A Sbjct: 237 NEKELIEALKTEEIAGAFLDVFEQEPPLE-------------DNPLLSMDNVIVTPHMAS 283 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E + ++ + + E + Sbjct: 284 NTEECMILMAVQAASEIVKVLSNEKPCWPV 313 >UniRef50_Q1K3M3 D-3-phosphoglycerate dehydrogenase n=1 Tax=Desulfuromonas acetoxidans DSM 684 RepID=Q1K3M3_DESAC Length = 528 Score = 360 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 89/327 (27%), Positives = 141/327 (43%), Gaps = 16/327 (4%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + V + + L+ +E+ G ++ + + K N +A+ + S ++ Sbjct: 1 MQVLISDNFSSAGLKLFDEAEGITADYQPGITHDNLLKIINNYDALIVRGGTTVSEELIF 60 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K+ +K IA G N+ +DAA G+ V P +AEHAI MMM+L R I + Sbjct: 61 AAKR--LKIIARAGIGVENIAMDAANIKGIVVTNTPLGSTTTIAEHAIAMMMSLARLIPQ 118 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A++ + G + KT GVIG GKIG ++ +G M + +DPY S + Sbjct: 119 AHESMSQGKWQSTEFLGSDINDKTLGVIGGGKIGRRVIEYARGLHMHVNLYDPYLSEEVI 178 Query: 183 -ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 LG V L L S +D ISLH PLT E +LN F +K G ++N + G LI+ Sbjct: 179 TRLGASKVSLEDLLSTADFISLHLPLTLETEQILNAETFAMVKPGCRLINCALGGLINED 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 + AL + +D + E RL NV+ T H T Sbjct: 239 DLVNALTDGTFAGAALDTFATEPPA-------------PDNRLLHMDNVICTPHLRAATV 285 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 +A T+++ + + +T N L Sbjct: 286 DAQTNVTVQAAHQVIDFLTNKTVRNAL 312 >UniRef50_UPI000197AFFA hypothetical protein BACCOPRO_00987 n=1 Tax=Bacteroides coprophilus DSM 18228 RepID=UPI000197AFFA Length = 315 Score = 360 bits (925), Expect = 4e-98, Method: Composition-based stats. Identities = 102/326 (31%), Positives = 156/326 (47%), Gaps = 21/326 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNE---SFGFELEFFDFLLTEKT-AKTANGCEAVCIFVNDDG 56 M + + + + L + G + L + + A + + I N Sbjct: 1 MNIVLLESLGISPERLSEYARPLVEAGHTFNAYPRDLDIQVQIERAREADVIII-ANMPL 59 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 V+ K +K+I + G ++VDLDAA+E G+KV Y +AVAE A+ MM++L Sbjct: 60 RGEVIRACKH--LKFIDVAFTGVDHVDLDAARECGVKVSNAAGYSTQAVAELALCMMLSL 117 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R + + R R + +GL G + GKT G++G G IG + K FG R+L + Sbjct: 118 LRNVPQVAGRCRQGK-TKDGLVGCELRGKTVGIVGAGAIGTRTAELCKAFGCRVLGNKRH 176 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + +E++ L L S+SD++SLHCPLT E L+N MK G ++NT+RG Sbjct: 177 LTGKEPSF-IEFMPLEELLSQSDIVSLHCPLTAETRQLINADRLGMMKQGAYLINTARGG 235 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++DS A EALKN + G+DV+E E L D L NVL T H Sbjct: 236 VVDSAALAEALKNGYLAGAGIDVFETEPPL------------DPAHPLLQAPNVLATPHV 283 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGE 322 AF + E++ + + NLSN G+ Sbjct: 284 AFASEESMEARAAIVFSNLSNWMDGK 309 >UniRef50_Q5WLJ2 D-3-phosphoglycerate dehydrogenase n=7 Tax=Bacteria RepID=Q5WLJ2_BACSK Length = 316 Score = 360 bits (925), Expect = 5e-98, Method: Composition-based stats. Identities = 93/325 (28%), Positives = 156/325 (48%), Gaps = 22/325 (6%) Query: 1 MKLAVYST--KQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK+ S ++ + + ++ + + + A G +A + N+ Sbjct: 1 MKVICTSPSFAKHSNEPIIRLQQEGIELVRVPPDISQSAFVLEARGAQAAIVAFNEIHDA 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 VL +L +K IA G +N+D+DAAK+ G+ V VP + AVA+ A ++++L R Sbjct: 61 -VLAQLPD--LKIIAKHGVGVDNIDVDAAKKHGVTVTNVPNANKHAVADFAFSLLLSLAR 117 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 +I ++T+ + L G +Y +T G+IG G IG + R GF M +LA+DPY Sbjct: 118 QIPTGNEKTKKGKWP--SLFGADVYQQTLGIIGLGAIGKEVARRASGFSMTVLAYDPYID 175 Query: 179 AA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A + G+E V L L +SD +++H PL PE HL+ E + MK +VN SRG + Sbjct: 176 RTYARKNGIEAVSLDALLQQSDFVTIHIPLLPETRHLIGERELQLMKKSAYLVNASRGGI 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D A EAL+ Q++ +DV+E E L + + + H A Sbjct: 236 VDETALYEALQTQQLAGAALDVFEEEPLH--------------MSPLFSLDSFIAMPHVA 281 Query: 298 FLTAEALTSISQTTLQNLSNLEKGE 322 T A+ ++S T + + + KG+ Sbjct: 282 GYTPGAINTLSHTCVDQIIAVLKGK 306 >UniRef50_C0GGJ9 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GGJ9_9FIRM Length = 335 Score = 359 bits (923), Expect = 8e-98, Method: Composition-based stats. Identities = 106/335 (31%), Positives = 177/335 (52%), Gaps = 13/335 (3%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + + T+ D+ + + L F + L++K + E + +F+ + +L Sbjct: 3 NITFFETQTGDRPAFETALK--DHSLSFTEEPLSDKNIADFSDSEIISVFIYSHATAELL 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 +L +K I R +GFN++DL AA E + V VP Y VAEHA +++TL+R I+ Sbjct: 61 SQLP--NLKLILTRSSGFNHIDLKAATERNIPVCNVPVYGENTVAEHAFALILTLSRNIY 118 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 +AY RT+ +FSL+GL GF + KT V+G G+IG+ +++I + F M++LA DP P Sbjct: 119 KAYLRTQREDFSLKGLQGFDLKDKTLAVVGAGRIGLHVIKIARSFNMKVLAVDPTPDPFL 178 Query: 182 LE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E L Y L + + +D+ISLH PL + +HLLN+ +K G +++NT+RG L+++ Sbjct: 179 AEVLQFSYAPLEEVLTRADIISLHAPLNEKTHHLLNKENISTIKKGALLINTARGELVET 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDV-------FRRLSACHNVLFT 293 A + AL + I G+DV E+E ++K L +V+ T Sbjct: 239 DALLAALNDGTIAGAGLDVLESEELFVEDEKLFSPHTPPETLTTVLKNHILLNREDVVIT 298 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H F + EA+ I +TT+QN++ G + N + Sbjct: 299 PHIGFNSKEAVHRIRETTVQNITAFLAG-SPENVV 332 >UniRef50_A7NS02 Glyoxylate reductase n=8 Tax=Bacteria RepID=A7NS02_ROSCS Length = 341 Score = 359 bits (922), Expect = 9e-98, Method: Composition-based stats. Identities = 84/341 (24%), Positives = 141/341 (41%), Gaps = 28/341 (8%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLL--TEKTAKTANGCEAVCIFVNDDGSR 58 M+ VY T++ + + V + + L E + + + + D Sbjct: 1 MRPRVYLTRRLPQAAVDIVTAACETTFWDDEALPVPRETLLRAVAEVDGILTLLTDRVDV 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +L+ + +K +A G++NVDL A G+ + P E A+ +++ +R Sbjct: 61 ELLDAAPR--LKVVANMAVGYDNVDLPALTARGVLLTNTPDVLTETTADLVWALILAASR 118 Query: 119 RIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R+ ++ +S + G ++G T G++G G+IG A+ R GFGM +L + Sbjct: 119 RVVEGHRLIAAGGWSTWSPMFMVGQDVHGATLGIVGAGRIGAAVARRAVGFGMPILYHNR 178 Query: 176 YPSAAALE-------LGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGV 227 +PS A + YV L L +ESDV+ + PLTPE + F MK Sbjct: 179 HPSPALEAQIRATPGAAIRYVPNLDDLLTESDVVVVMVPLTPETRGMFGAREFALMKPTS 238 Query: 228 MIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC 287 + VN SRG +I I+AL+ + + G+DV+E E L Sbjct: 239 VFVNASRGPVIREAELIDALQRGRPWAAGLDVFEREPIG-------------ADHPLLTL 285 Query: 288 HNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 NV+ T H T T ++ NL G+ PN + Sbjct: 286 PNVVLTPHIGSATVATRTRMAVVAATNLVAALTGQPVPNPV 326 >UniRef50_C2HP35 Glyoxylate reductase n=10 Tax=Lactobacillus RepID=C2HP35_LACAC Length = 330 Score = 359 bits (922), Expect = 9e-98, Method: Composition-based stats. Identities = 86/335 (25%), Positives = 142/335 (42%), Gaps = 25/335 (7%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK---TAKTANGCEAVCIFVNDDGSR 58 K V L + + + + K + V + + Sbjct: 12 KAKVLVLGGLIDDALDDLRSTCEVTVGPVGHRPNDDRQWVLKNIAKYDGVIV-AKMIFDK 70 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +++ K +K I+ GF+++D+D A+E G+ V P AE A+ M+M R Sbjct: 71 EIIDAAK--NLKVISTYGVGFDHIDIDYAREKGIVVTNCPNSVLRPTAELALTMIMASAR 128 Query: 119 RIHRAYQRTRDANF---SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 RI R+ F G+T+ GKT G++G G+IG + R K GM+++ + Sbjct: 129 RIRYYDHALREGVFLNVDEYDSQGYTIEGKTLGILGMGRIGQQVARFAKALGMKIIYHNR 188 Query: 176 Y--PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + EL YVD +L SD +SLH P T E YH++++ F MK+ ++N + Sbjct: 189 HQLKPELEAELNARYVDFASLVKNSDFLSLHAPATDETYHIIDKDVFNNMKDTSFLINVA 248 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG+L+DS + ALK KI +DV+ENE + L NV+ T Sbjct: 249 RGSLVDSDDLVAALKEGKIAGAALDVFENEPY--------------PKQDLVNMDNVIMT 294 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T +A ++++ N+ K N + Sbjct: 295 PHVGSATHKARYNLTKEAANNILTFFKEGKVINSV 329 >UniRef50_A1W9A3 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Acidovorax RepID=A1W9A3_ACISJ Length = 339 Score = 359 bits (922), Expect = 1e-97, Method: Composition-based stats. Identities = 109/333 (32%), Positives = 173/333 (51%), Gaps = 12/333 (3%) Query: 3 LAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + D+ +Q ++ + + L+ T A E +C+FV VL Sbjct: 9 VLFTDFAPTDQAAMQQRLPAHWHAHFVQREHLVASDTEDGA--IEVLCVFVRTRVDESVL 66 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 L + ++ +A R AGF+++DL+A ++ G+ V VP Y +VAEHA +++ + R + Sbjct: 67 RMLPR--LRLVATRSAGFDHIDLEACRKRGIAVCHVPDYGSASVAEHAFALLLGVTRHLT 124 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSAA 180 +A++R R +F+ GLTGF + G+T G++G G+IG + RI GFGM +LA+DP + ++A Sbjct: 125 QAHERARQGSFAYRGLTGFELEGRTLGIVGLGRIGRHVARIAVGFGMDVLAYDPAFAASA 184 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A GV V + SD++SLH P T HL++ AF +MK GV+++NT+RGALID Sbjct: 185 ARPAGVSLVTWEQVLQGSDILSLHVPATEATRHLIDARAFARMKPGVVVINTARGALIDE 244 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKS-----NDVIQDDVFRRLSACHNVLFTGH 295 A + AL + + + G+DV E E L E + L VL T H Sbjct: 245 AALLRALDDGSVAAAGLDVLEQEGALSPEVPTGCGGLGCDTGWMASSPLLTHPRVLVTPH 304 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T EA+ I T+ N++ G N + Sbjct: 305 VGFNTTEAIARIFDETISNIAAWHAGR-LRNRV 336 >UniRef50_A8SQC5 Putative uncharacterized protein n=4 Tax=Clostridiales RepID=A8SQC5_9FIRM Length = 343 Score = 358 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 153/330 (46%), Positives = 217/330 (65%), Gaps = 3/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M + Y TK+YD+ + + +++ + L+ +TA+ A G EA+C FV+ D S Sbjct: 14 MNILFYDTKKYDRDSFDAIKGGYPQLCIDYVEADLSVRTARLARGYEAICAFVSSDVSAA 73 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V+ L + GVK I +RCAGFNNVDLDA ++ G+ V+RVP Y PEAVAEHA+ + M +NR+ Sbjct: 74 VVNALSEVGVKLILMRCAGFNNVDLDATEKCGMTVLRVPGYSPEAVAEHAMALAMAVNRK 133 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +H++Y + R+ NFSL GLTG +GK AG++GTGKIG AM RI GFGM+++A+D Y + Sbjct: 134 LHKSYIKVRENNFSLVGLTGMNFHGKIAGIVGTGKIGAAMARICHGFGMKVIAYDMYKNP 193 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V YV+L LF SD+ISLHCPLT + YHL+N QMK+ V++VNTSRGALI Sbjct: 194 ELD--FVTYVELQELFRVSDLISLHCPLTDDTYHLVNADTIAQMKDKVILVNTSRGALIK 251 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ I ++++K +G+DVYE E FE++ +D+++ + RL + NV+ T HQ FL Sbjct: 252 TEDLIAGIRSRKFFGVGLDVYEEETGNVFENREDDILETSITARLLSFPNVIVTSHQGFL 311 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EAL +IS+TTL N N E G LV Sbjct: 312 TEEALEAISRTTLDNAVNFEAGNIDKANLV 341 >UniRef50_A5VLZ7 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=19 Tax=Lactobacillus RepID=A5VLZ7_LACRD Length = 330 Score = 358 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 106/330 (32%), Positives = 174/330 (52%), Gaps = 4/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG-SRP 59 MKL +YS + +K Y++ + G +++ L T K A G + + + Sbjct: 1 MKLIMYSVRDAEKPYIEAWEKKTGNDVKMVTEPLNADTVKLAEGYDGISLQQTTKLGDEQ 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + E+L G+K +A R G + DLDA K G+ V VP Y P A+AE + M L RR Sbjct: 61 LYEQLAAMGIKQLAARMVGVDIFDLDACKANGIIVTNVPIYSPRAIAEMGVTQAMYLLRR 120 Query: 120 IHRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 I QR +F + L +Y T G++G G IG A +I K G ++LA+DP + Sbjct: 121 IGEFEQRMSHGDFRWSDDLISNEIYNLTVGIVGLGNIGGATAQIYKALGAKVLAYDPSYN 180 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 E VEY D T+ +D++SLH PL P +++ F+ MK+ ++N +RG L+ Sbjct: 181 -VEYEPYVEYTDFDTVIKNADILSLHTPLLPSTENMIAAPQFKMMKDNAYLINMARGKLV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ I AL+N++I G+D +E F + ++D I DD +++L+A NVL T H AF Sbjct: 240 NTADLISALENKEIAGAGLDTLADETSFFGKQVTSDQIPDD-YKKLAAMPNVLVTPHVAF 298 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 LT ++ ++ + +L + + +G+ NE+ Sbjct: 299 LTETSIRNMVEISLNDAVTILEGKHSRNEI 328 >UniRef50_A8UL50 D-lactate dehydrogenase n=2 Tax=unclassified Flavobacteriales (miscellaneous) RepID=A8UL50_9FLAO Length = 351 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 142/329 (43%), Positives = 215/329 (65%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ VYS K ++ Y+++ N+ +++F L+ +TA A G EA+ IF D+ Sbjct: 17 MKVLVYSAKDFEIPYIEEANKRK-HKIDFTKDALSSETAMKAIGYEAISIFSADEACFIT 75 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+LK GVKYI LR G++N++L AA LG++V VPAY P A+AEH++ +++ LNR++ Sbjct: 76 IEKLKDFGVKYITLRSVGYDNINLRAASRLGIRVANVPAYSPYAIAEHSVALLLALNRKL 135 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + R NF+L L GF + KT G++GTGKIG M +I+ GFG +LL +D + Sbjct: 136 IESNFRVNHYNFNLNNLVGFDLNDKTVGIVGTGKIGAIMCKIMHGFGCKLLGYDIEENNT 195 Query: 181 ALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E + Y L L ++D+ISLH PL E + L+NE MK+GV+++NT+RG++++ Sbjct: 196 LKEYYNITYTSLKALCKQADIISLHVPLNTETHQLINEDLISFMKDGVILINTARGSVVN 255 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ I+ LKN KIG+LGMDVYENE+ +FF+D+S ++ DD+ +L+A NVL TGH AFL Sbjct: 256 TEDVIQGLKNGKIGALGMDVYENEKGVFFKDRSQNLPNDDLLLKLNAMPNVLITGHHAFL 315 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EALT+I++TT+ NL + NEL Sbjct: 316 TEEALTNIAETTIYNLDCWNLRKETENEL 344 >UniRef50_C4XIX3 Putative D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Desulfovibrio magneticus RS-1 RepID=C4XIX3_DESMR Length = 329 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 94/330 (28%), Positives = 145/330 (43%), Gaps = 22/330 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGSRPVLEE 63 V T+ + L + E + D LT ++ A + V + D + Sbjct: 8 VVVTRAIPEAGLALLRERATVWVNPEDRPLTRDELLAQAKDADGVIGLLTDRIDAGFFDA 67 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K ++ A G++N+D+ A GL V P +A AE A +++ R I + Sbjct: 68 CPK--LRGYANYAVGYDNIDVPEATRRGLPVSNTPDVLTQATAELAFALILATARHIVAS 125 Query: 124 YQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD-PYPSA 179 R +S G G + GKT G+ G G+IG+A+ R+ +GF M+++ P+ Sbjct: 126 DAVLRSGQWSGWGPLQFIGTQLAGKTLGIYGPGRIGLAVARLSRGFDMKIITCGGRKPNP 185 Query: 180 A-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A E G + + +DV+S+ PLT H N AAF +MK ++VNT RG +I Sbjct: 186 ALVAEFGAASLPFEAFLAAADVVSITAPLTDTTRHAFNAAAFARMKPTALLVNTGRGPII 245 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D A + AL+ +I G+DVYE E L L+A NV+ T H Sbjct: 246 DEAALVVALREGRIAGAGLDVYEFEPRLAEG--------------LAALPNVVITPHIGS 291 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++ QNL + +G T P L Sbjct: 292 ATTEAREGMAVLAAQNLIAMLEGTTPPTCL 321 >UniRef50_B1R2D5 Glycerate dehydrogenase n=6 Tax=Clostridiales RepID=B1R2D5_CLOBU Length = 314 Score = 357 bits (918), Expect = 3e-97, Method: Composition-based stats. Identities = 99/334 (29%), Positives = 157/334 (47%), Gaps = 25/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF---GFELEFFDFL--LTEKTAKTANGCEAVCIFVNDD 55 MKL++ +K+ + E E+ ++D +E + + E + + N Sbjct: 1 MKLSILEPLGVEKEKFLNMAEKVLGDRVEITYYDNRVEDSETLIERSKDAE-IVVLSNFQ 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 + V+E+ +K I + G ++VD+D K+ G+ V Y AVA+ G+++ Sbjct: 60 YRKDVIEKCP--NLKMICVAFTGVDHVDIDYCKDRGITVCNCAGYSTVAVADLVFGLLIN 117 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 + R I TR + GL GF + GK GVIGTG IG+ + I K FG + A+ Sbjct: 118 IYRNIVECNIVTRKGG-TKNGLVGFELEGKKFGVIGTGAIGMRVANIAKAFGCEVYAYSR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 ++YVDL TL S DVISLH PL L+NE + MK +++NT+RG Sbjct: 177 TVKEGKE---IKYVDLNTLLSTCDVISLHVPLNENTKGLINEENIKLMKKSAVLINTARG 233 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 ++DS+A +ALKN I G+DV+E E + V L N++ T H Sbjct: 234 PVVDSKALSDALKNNIIAGAGIDVFEIEPPI------------PVDHVLFDAPNLIVTPH 281 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AF T E++ ++ N+ G + N +V Sbjct: 282 VAFATKESMVKRAEIVFDNIDKYING-SSQNVIV 314 >UniRef50_Q1J0H2 D-3-phosphoglycerate dehydrogenase n=8 Tax=Deinococci RepID=Q1J0H2_DEIGD Length = 542 Score = 357 bits (917), Expect = 4e-97, Method: Composition-based stats. Identities = 78/326 (23%), Positives = 141/326 (43%), Gaps = 21/326 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + L GFE+++ L E+T + G +A+ R +LE Sbjct: 19 VLICDEMNPGDLH----HEGFEIDYEGNLPREETLRRLPGYDALITRSRTKVDRELLEAA 74 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K I G +N+DL+A G+ V+ P + + AE AI ++ R + R+ Sbjct: 75 GDR-LKVIGRGGVGVDNIDLEACSRRGILVLNAPESNNVSAAELAIMHLLAAARGLTRSD 133 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALE 183 ++TR + + G + KT G++G G+IG + +G ++++A+DPY P Sbjct: 134 RKTRAGEWDRK-FLGVELKDKTLGIVGLGRIGSIVADRAQGLRLKVVAYDPYVPENKFER 192 Query: 184 LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 LGVE L L + D +++H PLT E ++ +K G ++VN +RG ++ A Sbjct: 193 LGVERAATLDELLTRVDFLTVHTPLTEETNGMIGARELALLKRGAIVVNAARGGIVQEAA 252 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +EAL++ + + G+DV+ E + N+ T H T E Sbjct: 253 LVEALQSGHLFAAGVDVFVEEPPA-------------PDHPFLSAPNLGITAHLGANTFE 299 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A + + + G+ + Sbjct: 300 AQERVGAEIVGRVLAALHGDVSKGAV 325 >UniRef50_Q7UQL2 Phosphoglycerate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UQL2_RHOBA Length = 540 Score = 356 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 85/326 (26%), Positives = 148/326 (45%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + ++ + + S G E E L E+ ++ N +A + + LE Sbjct: 4 ILVLDDIAQEGIDLLEASEGIEYEVRTKLKGEELRQSLNEFDAAILRSGVTITPESLE-- 61 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ + G +N+D AA G+ V+ PA + + AEH M++ ++R I A Sbjct: 62 GNTRLRALVRAGVGTDNIDKPAATRRGIVVMNTPAGNTVSTAEHTFAMLLAMSRNIAAAN 121 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALE- 183 Q + + + G + GKT G++G G+IG + + F M ++AFDP+ + E Sbjct: 122 QSLVEGRWDRKKFMGTQVAGKTLGIVGMGRIGREVASRAQAFDMDVVAFDPFLTDDQAES 181 Query: 184 LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 L V V + + + D +++H PLTPE L+ E++K G+ I+N +RG + DS+A Sbjct: 182 LKVRRVATVDDMLPQIDYLTVHTPLTPETRGLIGMEQLEKVKPGLRIINVARGGIYDSEA 241 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +E LK+ K+G + +DVYENE L V+ T H T E Sbjct: 242 MVEGLKSGKLGGVALDVYENEPCT--------------DSPLFGMPGVVCTPHLGASTEE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A T ++ + L N + + + Sbjct: 288 AQTQVAVEGIHLLLNYLRTGEIRHSV 313 >UniRef50_UPI000038E3F5 glyoxylate reductase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E3F5 Length = 311 Score = 356 bits (916), Expect = 5e-97, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 147/329 (44%), Gaps = 24/329 (7%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 + T+ Y++++ E+ E+ + + + + + I +N+ + +++ Sbjct: 3 KILVTRNIPGNYIEKI-ENMEIEVFSGNGNMRDWLLSNIGSADGILITLNEKIDKELIDH 61 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 KK +K I+ G++++D++ AK G+ V P +A A+ G+M+ R I Sbjct: 62 GKK--LKVISTYSVGYDHIDVEYAKSKGIIVTNTPEVLTDATADLIFGLMIAAARNIVSG 119 Query: 124 YQRTRDANF----SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 ++ + + G ++GKT G+IG G+IG A+ R GF M+++ + + Sbjct: 120 NDLIHKNDWKAGWNPTFMLGSEIHGKTLGIIGMGRIGKAIARRASGFDMKIIYYSRHRHD 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 ++ + L +SD + + L + +H ++ +MK ++N +RG +++ Sbjct: 180 VD----ADFASIDELLQQSDFVIIALDLNADTFHFMDYQKISKMKKTAFLINGTRGKIVN 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + + AL + I +DV+E+E D + + NV+ T H Sbjct: 236 EKDLVRALNEKIIEGAALDVFEDEPV-------------DNTNPILSFSNVVVTPHLGSA 282 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E +++T + NL N+ G+ +L Sbjct: 283 TYETRDKMAETAVTNLVNVLNGKDPLYKL 311 >UniRef50_Q7UQC8 Probable 2-hydroxyacid dehydrogenase n=3 Tax=Bacteria RepID=Q7UQC8_RHOBA Length = 406 Score = 356 bits (915), Expect = 6e-97, Method: Composition-based stats. Identities = 85/334 (25%), Positives = 150/334 (44%), Gaps = 20/334 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFD-FLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK +V T+Q + L+++ E E+ E+ + G + ++D Sbjct: 86 MKHSVLVTRQIPGESLKRLREVCEVEVWPEAIPPSREELCRLVKGRHGLLTMLSDRIDGE 145 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +++ + + ++ GFNN+D+DAAK G+ V P +A A+ A+ ++ +R Sbjct: 146 LMDVAGE-QLCVVSNYAVGFNNIDVDAAKTRGVVVGNTPDVLTDATADLAVSLLFAASRH 204 Query: 120 IHRAYQRTRDANFSLE---GLTGFTMYGKTAGVIGTGKIGVAMLRILKG-FGMRLLAFDP 175 + A + R+ + G G KT G++G G+IG A + L G +GM LL Sbjct: 205 VLPAGNQVREGEWKTWEPTGWLGVEPSDKTLGIVGMGRIGKATAKRLVGGWGMNLLYTSR 264 Query: 176 Y-PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 ELG V+L TL +ESD +S+H LT E +L++ A +MK+ ++VNT+R Sbjct: 265 SDQGDVEKELGGRRVELDTLLAESDFVSVHVALTDETRNLIDADAIGKMKSTSVLVNTAR 324 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D A ++AL + I + G+DV E L + + Sbjct: 325 GEIVDQDALVDALNRRAIFAAGLDVTTPEPL-------------PADHALVKSPHCVILP 371 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T + ++S+ + NL G+ + Sbjct: 372 HIGSATHTSRNAMSEIAVDNLIAGLAGKPLRCSV 405 >UniRef50_B0NG91 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC 35704 RepID=B0NG91_EUBSP Length = 319 Score = 356 bits (915), Expect = 6e-97, Method: Composition-based stats. Identities = 95/334 (28%), Positives = 155/334 (46%), Gaps = 26/334 (7%) Query: 2 KLAVYSTKQYDKKYLQ---QVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDD 55 K V T + K ++ E ++ E+ + +AV + D+ Sbjct: 3 KYKVIVTARSFAKADDQALRLLEEHDCDVVRLVAGVATFDEQIKEEIAAADAVIAGL-DE 61 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 S+ +++ K +K I+ G++ VD++AA G+ V P + ++VA+ A+ +M+ Sbjct: 62 YSKELIDLAGK--LKVISRYGVGYDKVDVEAADRKGILVTITPGANGDSVADLAVTLMLD 119 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R + + + G M+ KT GVIGTG+IG + R KGF M++L +D Sbjct: 120 AARNVAAMDAAMK--GRAQARPQGVEMWQKTLGVIGTGRIGQGVARRCKGFDMKILCYDI 177 Query: 176 YPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 Y + A E +YVDL TL ESD I++H PLTPE ++ F+ MKN +IVNT+R Sbjct: 178 YENEAFKKECNAKYVDLSTLLRESDFITIHSPLTPETKDMIGAREFDMMKNDAVIVNTAR 237 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +I+ +A EALK+ I G+D +E L N + T Sbjct: 238 GGIINEEALYEALKSGSIRGAGLDATVDEPPY--------------DSPLMTLPNCILTP 283 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T EA + +S QN+ ++ C ++ Sbjct: 284 HAGAATKEASSKMSLMAAQNVVDVLTTGDCKYKV 317 >UniRef50_Q0W672 Glycerate dehydrogenase n=2 Tax=Archaea RepID=Q0W672_UNCMA Length = 319 Score = 356 bits (914), Expect = 8e-97, Method: Composition-based stats. Identities = 93/326 (28%), Positives = 148/326 (45%), Gaps = 19/326 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + + Y + ++ L E+ + + + + Sbjct: 4 IVIADAVSKHELYEHHFGKIGDLKVYRGPPLSMEEYLCRIAEADVAVV-SHFKLPARSFD 62 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 +K +AL G+++VDLDAA G+ V P Y EAVAEH M+++ RRI Sbjct: 63 ---SSTLKLVALTRTGYDDVDLDAATLKGVAVANAPGYSNEAVAEHVFAMLLSFIRRISE 119 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 A R+ F G + GKT G+IGTG+IG+ + I + FGM ++A+D + A Sbjct: 120 ADFWIREEKFDCTAFEGRELRGKTMGIIGTGQIGLRVAEIARCFGMDVIAYDVRRNPAVA 179 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E + YV L L +ESD I++H PLT + L++E +F MK G +I+NT+RG ++D A Sbjct: 180 EK-LRYVGLDRLCAESDFITVHLPLTSDTRGLIDEESFRLMKPGAVIINTARGPVVDQAA 238 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 + AL +I +DV++ E L A N L T H A+ T E Sbjct: 239 LLRALDEGRIAGACLDVFDQEPL-------------PPDSPLLAMSNTLLTPHIAYNTRE 285 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A +N++ G+ N + Sbjct: 286 AKEQSIAIAAENVALYLSGK-PRNIV 310 >UniRef50_A6LTK2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=15 Tax=Bacteria RepID=A6LTK2_CLOB8 Length = 327 Score = 356 bits (914), Expect = 9e-97, Method: Composition-based stats. Identities = 103/328 (31%), Positives = 196/328 (59%), Gaps = 3/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ YS ++ + +Y ++ ++ + E+ + + +TA A G + + I + + + + Sbjct: 1 MRILAYSHRRDETQYFEEFSKKYNVEVVLCNEEPSLETAPLAKGFDCISI-ITTNINSEL 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + + + GVK+I+ R G++++DL AKELG++V V Y P +VA++ I +++ R++ Sbjct: 60 VGKFHELGVKFISTRTIGYDHIDLKKAKELGVRVGNV-TYSPNSVADYTIMLILMAVRKV 118 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R+ +FSL G+ G + T GV+GTGKIG +++ L GFG ++LA D Y + Sbjct: 119 KLIMERSNVQDFSLRGIQGKELPNLTIGVVGTGKIGRTVIKHLSGFGCKILAHDIYENDE 178 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +YVDL LF SD+I+LH P T +NYH++N+ A + MK+GV I+NT+RG+LI++ Sbjct: 179 VKS-NAKYVDLENLFKYSDIITLHMPATDDNYHIINKKAIKLMKDGVFIINTARGSLINT 237 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 I ++++KIG +DV E E ++++ D + +++ L + NV+ T H AF T Sbjct: 238 NDLIHGIESKKIGGAALDVIEQESNIYYSDLKGEALKNRNLAILKSFPNVIITPHAAFYT 297 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +A++ + + ++++ + + P E+ Sbjct: 298 DQAVSDMIENSIKSCILFSENKENPWEI 325 >UniRef50_C8W7M7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Bacteria RepID=C8W7M7_ATOPD Length = 334 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 150/325 (46%), Positives = 210/325 (64%), Gaps = 5/325 (1%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ Y + YDK ++ + +++ + LT TA A G +AVC FVN D S Sbjct: 1 MKILFYGAQSYDKDSFNLELPKYPDVSIDYIESNLTPMTAGFAKGYDAVCAFVNADASIL 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 LE L VK + +RCAGF+ VD++AAK+LG+ V RVPAY PEA+AEHA+G+ + NRR Sbjct: 61 TLEILAGFDVKLLLMRCAGFDAVDVNAAKDLGITVTRVPAYSPEAIAEHAMGLALAANRR 120 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 IHR Y R R+ NFSL GL G T++GKTAG++GTG+IG A+ RI KGFGM +L D YP+ Sbjct: 121 IHRGYNRIRENNFSLVGLVGETLHGKTAGIVGTGRIGAALCRICKGFGMHVLGADLYPNM 180 Query: 180 A---ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + + EYV L+ +D ISLH L E+YH++N+ +MK+GV++VNT+RGA Sbjct: 181 SLVNDEHVVDEYVSYDELWERADFISLHAFLNEESYHMINDKTIGKMKDGVVLVNTARGA 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D++A I + + KIG+ G+DVYE E ++D++ +V D V L + NV+ T HQ Sbjct: 241 LVDTKALIRGILSGKIGACGLDVYEEENPNVYKDRAAEVF-DSVTSTLCSFPNVVMTSHQ 299 Query: 297 AFLTAEALTSISQTTLQNLSNLEKG 321 AF T EAL+ I+Q TL N + KG Sbjct: 300 AFFTHEALSQIAQVTLDNATAFAKG 324 >UniRef50_C4V5E1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V5E1_9FIRM Length = 334 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 86/329 (26%), Positives = 146/329 (44%), Gaps = 18/329 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ V + + G L + +T + +R V+ Sbjct: 3 KIYVTDYEYDSLAPEEHELARAGLTLIPQQCHTEDDVIRTCADASGLL-NQYAPITRRVI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L +K IA G N VDL+AA E G+ V+ VP Y + V+ HA ++M +R++ Sbjct: 62 EALPH--LKVIARYGVGVNTVDLEAATEHGVCVLNVPDYCADEVSNHAFALLMACHRKLA 119 Query: 122 RAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + + + + G+T G++G G+I + + FG++ +DP+ + A Sbjct: 120 PLHTQVNGGGWDYNICKPIHRLAGQTLGLLGFGRIPRLLAEKARAFGLKFAVYDPFVTPA 179 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + G + + L + SD+IS+H PLT E HLL+ F+ MK +++NTSRG LID Sbjct: 180 IVASYGGKLLTLGEVLQASDMISVHVPLTKETEHLLSHREFDMMKPSTILINTSRGPLID 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +A AL KI + G+DV E E L + N++ T H A+ Sbjct: 240 EEALYAALTQGKIAAAGLDVTEQEPLAQ-------------DSPLRSLPNIIITPHAAWY 286 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 + EA + + ++++ G PN + Sbjct: 287 SEEAECELKTKAARGIADILSGHDLPNIV 315 >UniRef50_C1DWX6 Glyoxylate reductase (Glycolate reductase) n=6 Tax=Aquificales RepID=C1DWX6_SULAA Length = 342 Score = 354 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 97/341 (28%), Positives = 174/341 (51%), Gaps = 18/341 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELE--FFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 MK+ + + +++ YL++ + G +++ F L + + +F+ ++ Sbjct: 1 MKVHFFEVEDWERLYLEKKIKDMGLDVDLGFTKEPLDDTNVDLYKDIDVAIVFIYSKLNK 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 VL ++ +K I R G++++D++ + G+ V VP Y VAE+ +++ L R Sbjct: 61 DVLSKM--QNLKLIITRSTGYDHIDVEYTSKNGITVCNVPGYGNNTVAEYTFALILALAR 118 Query: 119 RIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 + +RT FS +GLTG + GKT GVIG G+IG ++RI GFGM++L +D Y Sbjct: 119 KFKPMIERTSKGIFSRDGLTGIDLMGKTIGVIGAGRIGKHVIRIAYGFGMKILVYDRYKD 178 Query: 179 AAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 ++ G EYV L L SD+++LH P +HL+N+ + MK M++NTSRG + Sbjct: 179 QELIDKYGAEYVGLEDLLRMSDIVTLHVPYNKSTHHLINKFNIKLMKLDAMLINTSRGPV 238 Query: 238 IDSQAAIEALKNQKIG-SLGMDVYENERDLFFEDKSNDVIQDDVFRRL---------SAC 287 ++ +A ++ALK ++ +G+D +E + ++ D +L Sbjct: 239 VEMEAIVQALKEGRLAGGVGLDTFEA--EEVLIEEEYLKRDDIPAIKLKKALESFYVLHS 296 Query: 288 HNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 NV+ + H A+ T +AL I TL NL + +G N++ Sbjct: 297 ENVIVSPHNAYNTKDALYRILDITLDNLKSYLEGN-PKNKV 336 >UniRef50_D1C3Y3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C3Y3_SPHTD Length = 316 Score = 354 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 90/324 (27%), Positives = 142/324 (43%), Gaps = 21/324 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + D L + ++ L ++ G + + + + V+E Sbjct: 9 ILVCDPIDDGALDLLRRHARVDVRT--SLAPDELVDIVGGYDGLVVRGTTQITSEVIEAA 66 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 ++ IA +N+D+DAA E G+ VV P AVAE IG+++ + R I A Sbjct: 67 TA--LRGIARVGFAVDNIDIDAATERGIVVVHSPGARTYAVAEMTIGLILAVLRHIPAAD 124 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALEL 184 + + + G + G T GVIG G+IG + R+ FG + A+ P Sbjct: 125 RSVKAGRWERRAFRGRQLRGATVGVIGYGRIGREVARLAHAFGATVKAYTQTPRPLEH-- 182 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 + VD L + SD+I+LH LT L+N A EQM++GV+IVNT+ G LID A + Sbjct: 183 -AKQVDFQALLASSDIITLHATLTSATRQLINREAIEQMRDGVVIVNTASGGLIDEAALL 241 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 EAL K+ G+DV+ +E R L V+ T T EA Sbjct: 242 EALDRGKVAGAGLDVFADEPPS--------------LRALVEHPRVVTTPRIGGSTQEAD 287 Query: 305 TSISQTTLQNLSNLEKGETCPNEL 328 ++S+ LQ+L + +GE + Sbjct: 288 RAVSELALQSLLAVLRGEQPAVAV 311 >UniRef50_D1VVP3 Phosphoglycerate dehydrogenase n=1 Tax=Peptoniphilus lacrimalis 315-B RepID=D1VVP3_9FIRM Length = 315 Score = 354 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 80/321 (24%), Positives = 137/321 (42%), Gaps = 10/321 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + + + + G E + ++ K + + + V+ + + Sbjct: 1 MKALIIDQMSEE---IDKGLKERGIEFKKVMLPKKDELIKLIPDVDVLIMRVDPFIDKDI 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ K +K I + G N++DL+ K+ + V+ P + AVAE + L R Sbjct: 58 LDAAK--NLKLILVGSVGTNHIDLEECKKRNIPVMNSPGQNSNAVAELVFSKALDLYRNT 115 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + ++ G + KT G++G G IG + I F M +LA+DPY Sbjct: 116 VQANNEVKSGIWNKYRWIGRELRNKTMGILGYGSIGRRVAEIAHVFKMDVLAYDPYFDPK 175 Query: 181 ALELG-VEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 V+ V L SDVI+LH PLT E ++++ E M++G +++N +RG +ID Sbjct: 176 NNPYDYVKLVSLDEALKNSDVITLHLPLTKETKNMISSKQMEGMRDGTILINAARGGVID 235 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A E +KN K+G +D +E D + +L V + H Sbjct: 236 EDALYEYIKNGKLGGANLDTLADE----LGTGGLDTQDVPISSKLFELDRVYMSPHIGGS 291 Query: 300 TAEALTSISQTTLQNLSNLEK 320 T +A I LQ+L K Sbjct: 292 TIDAQDDIGHLVLQHLDEFLK 312 >UniRef50_Q3AQU0 D-3-phosphoglycerate dehydrogenase n=6 Tax=Chlorobiaceae RepID=Q3AQU0_CHLCH Length = 538 Score = 354 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 76/329 (23%), Positives = 136/329 (41%), Gaps = 19/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + ++ GFE+ L ++ + + V Sbjct: 13 MKVLITDSV---HPQCGRLLLQHGFEVTEKPSLSPKELHAIIADYNILIVRSATSLPAEV 69 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L K ++ I G +N+DL+AA G+ V+ P + + AEH M++ R I Sbjct: 70 L--AKATQLELIGRAGTGVDNIDLEAATRQGIVVMSTPGGNAVSAAEHTCAMLLAAARHI 127 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A + N++ G + GKT +IG G++G + ++ FGMR +A+DP + Sbjct: 128 PQAMADLKQGNWNKHLYAGIELEGKTLSLIGLGRVGREVAMRMQAFGMRTIAYDPAIADE 187 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 L +E + L +DVI++H L Y+LL + K GV+IVN +RG +I+ Sbjct: 188 DAALLDIELLPLHENLLRADVITIHSALDESTYNLLGKETLSLTKPGVIIVNCARGGIIN 247 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A EAL + + + +DV+ E L V+ T H + Sbjct: 248 EVALAEALASGHVAAAALDVFTKEPIA-------------ATHPLLQFPQVIATPHISAS 294 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 TAE ++ + + ++ + Sbjct: 295 TAEGQEKVAIQMAEQIIAWKRDGILEGAI 323 >UniRef50_A8MD25 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MD25_CALMQ Length = 326 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 104/335 (31%), Positives = 156/335 (46%), Gaps = 30/335 (8%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDF-----------LLTEKTAKTANGCEAVCIFVN 53 +Y T+ K L + GF+LE +D + A+ C+A+ + + Sbjct: 1 MYLTRSTFPKLLYDTLRNAGFDLEVWDNKGHGMWDRAAAPPRDVLRDAASRCDALVVTIG 60 Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 D VL K VK IA G++++DLDAA G+ V P EAVA+ AIG++ Sbjct: 61 DRVDDYVLSNAK---VKVIATYSVGYDHIDLDAATRRGIPVGYTPEVLVEAVADLAIGLI 117 Query: 114 MTLNRRIHRAYQRTRDAN--FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 +TL RR+ + R G ++GKT G++G G IG A+ R K F M ++ Sbjct: 118 ITLARRVIEGDRLVRSGEAYKVWGEFLGTEVWGKTLGILGLGNIGAAVARRAKAFNMNVI 177 Query: 172 AFDPYPSA-AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + + LG+ YVDL LF +SD + L L+ E YH++NE MKN +V Sbjct: 178 YWSRTRKPWIEVALGLRYVDLNELFRQSDYLVLTVALSKETYHIVNEERLRLMKNTSYLV 237 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RGA++D+ A ++ALK I +DVYE E L +NV Sbjct: 238 NVARGAVVDTNALVKALKEGWIAGAALDVYEEEPI-------------PNTHELIKLNNV 284 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCP 325 + T H A T E +++ T N+ N+ T P Sbjct: 285 ILTPHIASATVETRNKMAEVTALNVINVLLKNTKP 319 >UniRef50_C9KNY1 D-lactate dehydrogenase n=2 Tax=Clostridiales RepID=C9KNY1_9FIRM Length = 432 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 150/329 (45%), Positives = 207/329 (62%), Gaps = 9/329 (2%) Query: 2 KLAVYSTKQYDKKYLQQVNESFG-----FELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 K+A + TK YD+ Y ++ + G EL++F LT++TA ANG +AVCIFVND+ Sbjct: 95 KVAFFGTKDYDRLYFSELAKDRGEGTYNVELKYFASRLTDETAHLANGYDAVCIFVNDEA 154 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 R V+E+L GV+ I LRCAGFNNVD AA E G+ V+RVPAY P AVAEHA+ + Sbjct: 155 PRSVIEQLHDGGVRLILLRCAGFNNVDKKAAAEYGITVLRVPAYSPYAVAEHAMATLQAA 214 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 NRR+H+AY + RD NF L GL G ++ K AG++GTG+IG M RI KG+GM ++ +D + Sbjct: 215 NRRLHKAYNKVRDNNFDLTGLLGVDLHNKVAGILGTGRIGQCMARICKGYGMTVIGWDAF 274 Query: 177 PSAAALELG-VEYVDLPTLFSESDVISLHCPLT---PENYHLLNEAAFEQMKNGVMIVNT 232 P+ E G + Y + S SD+IS+H PL YHL++E A MK+ VM+ N Sbjct: 275 PNKKLEEEGLLTYASKEEVLSRSDLISIHAPLIMGEGGTYHLIDEKAISLMKDDVMLTNA 334 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG LID++A I ALK K ++ +DVYE E + D S+DV +D+ RL V+ Sbjct: 335 ARGGLIDTEALIAALKKGKFHAVALDVYEGEDANVYTDHSSDVPTEDITGRLLMFPQVIL 394 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKG 321 T HQAF T EAL +I+ T++N N +G Sbjct: 395 TSHQAFFTREALQAIATVTMENARNFNEG 423 >UniRef50_A9A1H5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Archaea RepID=A9A1H5_NITMS Length = 310 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 147/319 (46%), Gaps = 19/319 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + D L ++ + G ++ + + E+ + + V + ++ ++++ Sbjct: 7 VLICDEVD-PILNKILQDNGLKISYEPEITPEQILEKISDYNIVIVRSRTTITKEMIDKA 65 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K IA G +NVD +AAK ++V+ AVAE +G+M++L R+ R Sbjct: 66 --DNCKIIARVGVGLDNVDQEAAKAKNIRVINAVEGAMNAVAELVLGLMLSLARQTARGD 123 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA--L 182 + R+ + + L G + GK G++G G IG + R+ + M ++ +D P Sbjct: 124 RGIRNEQWLKKELKGTELAGKYLGIVGLGNIGKRLGRLARALNMNIIGYDVVPIDEEFSK 183 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E+G+ DL TL +D +S+H PL YHLL+ MK I+NTSRG ++D A Sbjct: 184 EVGLMKADLNTLLQSADYVSIHVPLLDSTYHLLDAQKMSTMKKTAKIINTSRGGVVDEDA 243 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 +ALKN +G +DV+E E + +L+ NV+ T H T E Sbjct: 244 LYDALKNGTLGGAALDVFEKEPAIGT--------------KLAELDNVILTPHIGAQTKE 289 Query: 303 ALTSISQTTLQNLSNLEKG 321 A + + + + + +G Sbjct: 290 AQSLAANVIAEKIVQILRG 308 >UniRef50_C3XA69 Dehydrogenase n=2 Tax=Oxalobacter formigenes RepID=C3XA69_OXAFO Length = 322 Score = 353 bits (908), Expect = 4e-96, Method: Composition-based stats. Identities = 79/330 (23%), Positives = 144/330 (43%), Gaps = 20/330 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + + + V E+ G + F + G A C + V Sbjct: 6 IVITDCNHINIDAEKAVFEAAGIPWKLFQCRTEDDLIANCQGAVAAC-NQRAPFTEKVFA 64 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 L + +K + G +NVDL+AA G++V VP Y VA HA+ MM+ + R+I + Sbjct: 65 ALPE--LKMVVRYGDGVDNVDLEAATRHGVQVCNVPDYGTSEVANHALAMMLAITRKICQ 122 Query: 123 AYQRTRDANFSLEGLTGFT-MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY---PS 178 A ++ R+ ++ + + T GVIG G+IG+A + + G +++ FD + Sbjct: 123 ANEQVREGRWTYREMVPIQHLSNMTIGVIGLGRIGLAFAKRVHALGCKVIGFDIFTEHLK 182 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 +E + +D++SLHC L ++ L+N F +MK G M +N +RG L+ Sbjct: 183 GDPESSFIELTSEDDVIERADLLSLHCSLNSQDAGLMNAKTFAKMKPGAMFINVTRGGLV 242 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 D +A +AL + + + +DV E + L + N+L T H A+ Sbjct: 243 DEKALADALNSGHLSAAALDVTAKEPL-------------PMDSPLRSAPNILITPHMAW 289 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + +A +++ + +GE N + Sbjct: 290 YSVQAESNLKTRCAEEAVRGFRGEKPRNPV 319 >UniRef50_C2HJZ3 Possible glyoxylate reductase n=2 Tax=Finegoldia magna RepID=C2HJZ3_PEPMA Length = 313 Score = 353 bits (907), Expect = 6e-96, Method: Composition-based stats. Identities = 94/333 (28%), Positives = 154/333 (46%), Gaps = 28/333 (8%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFL---LTEKTAKTANGCEAVCIFVNDDGSRP 59 + V T + ++ +++ E FE+++ D L E+ E + +++ Sbjct: 1 MKVLITNRIPEEIIKKYEE--NFEVDYHDSLDFLSKEELKTRIKDVEGLVCPLSEKIDSE 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPA-YDPEAVAEHAIGMMMTLNR 118 +++ K +K IA AGF+NVD+D AKE G+ V PA ++ AE G+M+ L R Sbjct: 59 IIDAAK--NLKIIANYGAGFDNVDIDYAKEKGIIVTNAPASASTKSTAELTFGLMIDLLR 116 Query: 119 RIHRAYQRTRDANFSLEGLT---GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 I + D +F G T+ GKT G+IG G+IG ++R K F M ++ ++ Sbjct: 117 NITKMNSDCYDNSFEGWKPVYGLGETLEGKTLGIIGLGRIGTEVMRKAKAFDMNVIFYNR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 G + VDL L SDVI+LH + + +HL++ AF +MK ++N SRG Sbjct: 177 SKKEVD---GAKQVDLNYLLENSDVITLHTAYSEKLHHLIDAKAFSKMKKSAYLINASRG 233 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +I Q I AL + +I +DVYE E + + L N+L H Sbjct: 234 KVISEQDLINALNDGEIAGCALDVYEFEPKISED--------------LRNAKNILLAPH 279 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A + + T N+ + GE N++ Sbjct: 280 LGNATKLARVQMGEFTFDNIMQFKNGEIPKNKV 312 >UniRef50_Q89388 A53R protein n=3 Tax=Chlorovirus RepID=Q89388_PBCV1 Length = 363 Score = 352 bits (905), Expect = 8e-96, Method: Composition-based stats. Identities = 143/333 (42%), Positives = 206/333 (61%), Gaps = 8/333 (2%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 +A++S Y K +++ + + + L E TA AN C+A+ FVNDD S PVL+ Sbjct: 32 VAIFSAGNYVKDFIKPI--ESICTPVYIESSLNETTAALANKCDAINAFVNDDLSAPVLD 89 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 LK GV I LRCAGF+ +D++ AKELG V RVPAY P +VAE A+ MM L+R I Sbjct: 90 ILKNCGVSSITLRCAGFDRLDIEYAKELGFNVYRVPAYSPRSVAELALTHMMALSRNIQL 149 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 R + N+++EGL G + KT G+IGTGKI ++++K R++A+D Y + Sbjct: 150 VLPRVKTGNYTMEGLVGREITDKTIGIIGTGKIAQEFIKLVKPMAGRIIAYDVYENDIVK 209 Query: 183 ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 E+GVEY+ LP + ESDV+SLHCPL +H++NE + MK +I+NT+RG LID++A Sbjct: 210 EMGVEYMSLPDVIKESDVLSLHCPLMKSTFHMINEDTLKTMKKTAVIINTARGGLIDTEA 269 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQ------DDVFRRLSACHNVLFTGHQ 296 I+AL++ I MDVYE+E LFF D++ I+ D F RL+ N + + H Sbjct: 270 LIDALESGVISGCAMDVYEHESGLFFTDRAVLPIEDRMKFWDKKFARLANLPNAIVSPHV 329 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 AFLT EAL +I+ TT++NL++ KGE N +V Sbjct: 330 AFLTKEALKNIADTTIENLTSAFKGERNNNNMV 362 >UniRef50_B1L1I5 D-lactate dehydrogenase n=16 Tax=Clostridium RepID=B1L1I5_CLOBM Length = 334 Score = 351 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 102/333 (30%), Positives = 166/333 (49%), Gaps = 5/333 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR- 58 MK+ +YS ++++K +++ E+ G +++ + L+E T A + + I + R Sbjct: 1 MKILMYSVREHEKPAIKKWLEANPGVQIDLCNEALSEDTVCKAKEYDGIAIQQTNSIGRK 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V LK++G+K IA R AG + +DL A + + V VPAY P A+AE A+ M L R Sbjct: 61 DVYSILKEYGIKQIASRTAGVDMIDLKMASDSNILVTNVPAYSPNAIAELAVTHTMNLLR 120 Query: 119 RIHRAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 I +R ++ L + T GV+GTGKIG ++ KG G ++ +D YP Sbjct: 121 NIKTLNKRIAYGDYRWSADLIAREVRSITVGVVGTGKIGRTSAKLFKGLGANVIGYDAYP 180 Query: 178 SAAALELGV-EYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 E + Y L L E+DV++LH PL +++N+ + MK IVNT RG Sbjct: 181 DKKLEENNLLTYKESLEDLLREADVVTLHTPLLESTKYMINKNNLKYMKPDAFIVNTGRG 240 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +I+++ IEAL+ KI +D +ENE + + D +L VL T H Sbjct: 241 GIINTEDLIEALEQNKIAGAALDTFENEGLFLNKVVDPTKLPDPQLDKLLKMDQVLITHH 300 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T A+ +I T+L ++ + K N++ Sbjct: 301 VGFFTTTAVQNIVDTSLDSVVEVLKTNNSVNKV 333 >UniRef50_B2I1D3 Phosphoglycerate dehydrogenase n=2 Tax=Acinetobacter baumannii RepID=B2I1D3_ACIBC Length = 325 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 91/326 (27%), Positives = 152/326 (46%), Gaps = 20/326 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELE-FFDFLLTEKTAKTANGC--EAVCIFVNDDGS 57 MK V T +S +L ++ +K K + +A+ + S Sbjct: 1 MKRKVLITGPTLTSDALLYAQSHDIQLIPTEPYMAKDKMEKLIHDEQPDAIIVR-TGKLS 59 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 R ++ +K IA GF+ +D AA E + V + ++VAEHA +M + Sbjct: 60 RDMI--FASDNLKVIAKHGVGFDTIDTQAAAERKIPVTIAVGANAQSVAEHAFALMFNVA 117 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R++ QR R+ ++ G +YGKT G+IG G IG +++++ M++ +DP+ Sbjct: 118 RQVTWLDQRIREGHWDKASANGVELYGKTLGLIGLGAIGSILMKLVAPLNMKVKVYDPFL 177 Query: 178 SAAALELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 VE D L SD+ISLHCPLT EN HL + + FE+MK+ +++NT+RG Sbjct: 178 QNLPELDYVEQEHDFEKLIETSDIISLHCPLTAENKHLFSHSQFEKMKSSSILINTARGE 237 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 LID A ++ALKN KI G+D + +E + L N++ T H Sbjct: 238 LIDQAALVDALKNNKIAGAGLDTFSSEPP-------------EKDNPLWELPNLVVTPHI 284 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGE 322 T ++ + L+ + ++ G+ Sbjct: 285 GANTTDSRNRVGLLALEQIMSIWNGQ 310 >UniRef50_A1HMI9 Phosphoglycerate dehydrogenase n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HMI9_9FIRM Length = 326 Score = 351 bits (903), Expect = 2e-95, Method: Composition-based stats. Identities = 85/331 (25%), Positives = 154/331 (46%), Gaps = 21/331 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + D L + + G + ++ L ++ + N + + + ++ ++ Sbjct: 3 KVIYFDKVFPDMVELIESIKPSGVTVTYWYTLNDKEKEQALNSADYFLVALY-KITQELI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 ++ K +K I G +N+DL AAK LG+ V P + +VAE +GM++ L R+I+ Sbjct: 62 QKAPK--LKMIQKTGVGVDNIDLAAAKTLGIPVANTPGGNATSVAELTLGMIINLYRKIN 119 Query: 122 RAYQRTRDANFSLEGLT--GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + T+ N+ + + GKT G+IG G IG + R+ + FG ++ +D Sbjct: 120 ILDRETKKGNWMSWEFRPSSYEVKGKTHGIIGFGNIGREVARLSQAFGTNVIYYDLRRLE 179 Query: 180 AALE--LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A E L V Y +L L +SD+IS+H PLTP+ +L++E +K +++N +RG + Sbjct: 180 PAEEKRLNVTYHELNELLQKSDIISIHLPLTPDTKNLISERELALLKPTALLINVARGNI 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D A ALK K+ G+DV+ E L +NVL T H Sbjct: 240 VDEVALYRALKENKLLGAGIDVWSKEPVE--------------DNPLLTLNNVLATPHIG 285 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T + L ++ +N+ +G+ + Sbjct: 286 AGTRDTLQTVLGLAFENIIATTRGKNPRFVV 316 >UniRef50_Q59642 D-lactate dehydrogenase n=5 Tax=Lactobacillaceae RepID=LDHD_PEDAC Length = 331 Score = 351 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 105/328 (32%), Positives = 175/328 (53%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ Y + +K YL + E++ LL A + V + + + Sbjct: 1 MKIIAYGIRDDEKPYLDEWVTKNHIEVKAVPDLLDSSNIDLAKDYDGVVAYQQKPYTADL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +++ + G+ +LR G +NV DA K+ +K+ VPAY P A+AE ++ ++ L R+I Sbjct: 61 FDKMHEFGIHAFSLRNVGLDNVPADALKKNDIKISNVPAYSPRAIAELSVTQLLALLRKI 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 + ++ E G + T GVIGTG+IG A + I K FG +++A+D + + A Sbjct: 121 PEFEYKMAHGDYRWEPDIGLELNQMTVGVIGTGRIGRAAIDIFKPFGAKVIAYDVFRNPA 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + G+ L L+ +++VI+LH P +NYH+L+E AF QM++G I+N +RG L+D+ Sbjct: 181 LEKEGMYVDTLEELYQQANVITLHVPALKDNYHMLDEKAFGQMQDGTFILNFARGTLVDT 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A ++AL + K+ +D YENE +F D + I D VF L + NV+ T H AF T Sbjct: 241 PALLKALDSGKVAGAALDTYENEVGIFDVDHGDQPIDDPVFNDLMSRRNVMITPHAAFYT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++ Q L N +L + + NE+ Sbjct: 301 RPAVKNMVQIALDNNRDLIEKNSSKNEV 328 >UniRef50_C1DZN2 D-Lactate dehydrogenase n=2 Tax=Micromonas RepID=C1DZN2_9CHLO Length = 339 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 144/303 (47%), Positives = 192/303 (63%), Gaps = 11/303 (3%) Query: 27 LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDA 86 + + D LT +TA A GC A C+FVND ++ L GV++IA+RCAGF+ VDLDA Sbjct: 18 VRWLDVGLTPQTAPLAAGCNATCLFVNDRADAETIDALADLGVRFIAMRCAGFDRVDLDA 77 Query: 87 AKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKT 146 G+ V RVPAY P A+AEHAI MM+ LNR++ + + R N+SL GL GF M+GKT Sbjct: 78 CARRGVAVTRVPAYSPYAIAEHAIAMMLALNRQLMKGHARVVQGNYSLSGLVGFDMHGKT 137 Query: 147 AGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVD-LPTLFSESDVISLHC 205 G++GTGKIG +IL G G +LA+D + S A+ +GV+YVD + L ++SLHC Sbjct: 138 VGIVGTGKIGRCTAKILLGMGCEVLAYDVFQSKEAIAMGVKYVDTVQELLPRCQIVSLHC 197 Query: 206 PLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERD 265 PLT + YHL+++A F M+ G M+VNTSRG L+D+ A AL QKI + MDVYE+E Sbjct: 198 PLTDDTYHLMDDATFNLMRKGSMLVNTSRGGLVDTAALARALDAQKIACVAMDVYEHEAG 257 Query: 266 LFFEDKSNDVIQDDVFR----------RLSACHNVLFTGHQAFLTAEALTSISQTTLQNL 315 LFFEDKS + L++ NVL T HQAFLTAEAL +I+ TT++NL Sbjct: 258 LFFEDKSEETDATPGSSLSPDWDLSLGSLASRPNVLVTSHQAFLTAEALGNIASTTVENL 317 Query: 316 SNL 318 Sbjct: 318 REF 320 >UniRef50_O83080 D-lactate dehydrogenase n=2 Tax=Treponema pallidum RepID=LDHD_TREPA Length = 331 Score = 351 bits (901), Expect = 3e-95, Method: Composition-based stats. Identities = 106/330 (32%), Positives = 179/330 (54%), Gaps = 3/330 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M+ V++ ++ + Y+++ +S G ++ ++ LT K + G E + + Sbjct: 1 MRCVVFNLREEEAPYVEKWKQSHPGVVVDTYEEPLTAKNKELLKGYEGLVVMQFLAMEDE 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 V + + +K ++ R AGF+ + K+ G+++ VP+Y P A+ E+A+ + L R Sbjct: 61 VYDYMGACKLKVLSTRTAGFDMYNATLLKKHGIRLTNVPSYSPNAIGEYALAAALQLTRH 120 Query: 120 IHRAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 R +F + + + G++GTG+IG A R+ KG G +++ FDPYP+ Sbjct: 121 AREIETFVRKRDFRWQKPILSKELRCSRVGILGTGRIGQAAARLFKGVGAQVVGFDPYPN 180 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 AA E + YV + L S SDVISLH P T +++HL+N QMK+GV +VNT+RGA+I Sbjct: 181 DAAKEW-LTYVSMDELLSTSDVISLHMPATKDSHHLINAKTIAQMKDGVYLVNTARGAVI 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 DSQA +++L KI +D YE E +D N+ I D V+ RL A +++T H AF Sbjct: 240 DSQALLDSLDKGKIAGAALDAYEFEGPYIPKDNGNNPITDTVYARLVAHERIIYTPHIAF 299 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ ++ +L + + +GE C E+ Sbjct: 300 YTETAIENMVFNSLDACTTVLRGEPCAAEI 329 >UniRef50_D2QQC4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Spirosoma linguale DSM 74 RepID=D2QQC4_9SPHI Length = 329 Score = 351 bits (901), Expect = 3e-95, Method: Composition-based stats. Identities = 129/322 (40%), Positives = 189/322 (58%), Gaps = 4/322 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M +A +ST +++ + Q + + +LT KTA A G AVC FVNDD SRPV Sbjct: 1 MNIAFFSTLSFEQAWFDQYRAH--HRITYIPEVLTTKTAHLAQGHNAVCTFVNDDLSRPV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L LK+ + + +RC G +NVDL A +LG+ ++ +Y P ++AEH + ++M + R + Sbjct: 59 LTLLKEMRIGVVGMRCMGTDNVDLQAITDLGMTLLHT-SYSPYSIAEHTVALLMGMVRHL 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A+ R + NF+++GLTG+ ++GKT G++GTG IG A +RI+ GFG ++LA+D P Sbjct: 118 PEAHNRVQARNFTIDGLTGYDLHGKTVGIVGTGHIGKAFIRIMLGFGCKVLAYDVCPDRR 177 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 E+GV YV LP L +SDV+SLHCP T H++NE MK ++VNT RG L+D+ Sbjct: 178 LTEIGVTYVSLPELLRQSDVVSLHCPSTSITQHMINEQTLSLMKQSAILVNTGRGRLVDA 237 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + AL K+ DVYE ERD F D S + DD+ RL VL T HQ FLT Sbjct: 238 HAVLNALDAGKLAGYAADVYEGERDYFHYDYSGKSVPDDLLNRLRKHPGVLLTAHQGFLT 297 Query: 301 AEALTSISQTTLQNLSNLEKGE 322 +AL I+ + + + + Sbjct: 298 EDALRQIALSLINQF-SFFDNK 318 >UniRef50_B9XQY4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=bacterium Ellin514 RepID=B9XQY4_9BACT Length = 334 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 92/334 (27%), Positives = 146/334 (43%), Gaps = 22/334 (6%) Query: 1 MKLAVYSTKQ-YDKKYLQQ--VNESFGFELE---FFDFLLTEKTAKTANGCEAVCIFVND 54 M V T +K + ++ G E+ +E K +AV V + Sbjct: 1 MSWKVVITAPPIEKVGQNAVALLKAAGCEVVNSAILGSPGSEDVLKIIKDADAVIAGV-E 59 Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 S V + +K I+ GF+ +D+ +A G+ + P E+VA++ +G+++ Sbjct: 60 KYSADVFSVPETKRLKLISRWGVGFDAIDVTSATREGILITYTPGMTDESVADYTMGLLL 119 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 L RRI Y+ + G M GKT G++G G+IG A+ R KGFG+ L+A D Sbjct: 120 ALVRRIIDGYETMSKGLWQPAW--GHDMNGKTLGILGYGRIGQAVARRAKGFGLELIAHD 177 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 P+P + G ++V L SD +SLH LT L+ EA ++MK ++N +R Sbjct: 178 PHPPMGTDQFGTQFVSFNELLERSDYLSLHATLTSSTRDLIGEAQLQKMKPSAYLINAAR 237 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G L++ QA I AL I +D + E V N+L + Sbjct: 238 GPLVNEQALIRALNEGWIAGAALDAFTVEPL-------------PVDHPFRRTPNLLLSP 284 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 HQA + E+ IS T Q + +L G+ L Sbjct: 285 HQASSSRESGELISLATAQAVLDLMAGKKPKMPL 318 >UniRef50_Q18DJ4 Phosphoglycerate dehydrogenase n=13 Tax=Halobacteriaceae RepID=Q18DJ4_HALWD Length = 534 Score = 350 bits (900), Expect = 4e-95, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 144/329 (43%), Gaps = 18/329 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + V T D L+++ + G +E + E T A+ + D + V Sbjct: 1 MHMQVLVTDPIDDAGLERLR-AAGHGVETAYDIGDEALLNTITDVNALVVRSGTDVNEAV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E + + G +N+D+DAA E G+ V P + A AEH + M R I Sbjct: 60 FEAASD--LIIVGRAGIGVDNIDIDAATEHGVIVANAPEGNVRAAAEHTVAMTFAGARSI 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +A+ R R ++ G + GKT GV+G G++G + + L+ GM L+A+DPY S Sbjct: 118 PQAHARLRTGEWAKSEYLGTEVNGKTLGVVGLGRVGQEVAKRLESLGMDLVAYDPYISED 177 Query: 181 -ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A LG E V+ T ++ +++H PLT E +++ E M +G ++N +RG ++D Sbjct: 178 RAERLGAELVEFDTCLERAEFLTVHTPLTSETAGMISTTELELM-DGGYLINCARGGVVD 236 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 A A+++ + +DV+ +E L + N++ T H Sbjct: 237 EDALAAAVEDGVLDGAAVDVFADEPVA-------------PDSALLSVDNIVVTPHLGAS 283 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A +++ + + G N L Sbjct: 284 TEAAQENVATSIADQIDAAFAGAPVMNAL 312 >UniRef50_P17584 D-2-hydroxyisocaproate dehydrogenase n=9 Tax=Lactobacillus RepID=DHD2_LACPA Length = 333 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 104/329 (31%), Positives = 178/329 (54%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ Y + + +Y +Q + G LE+ L E T + A G + + + V Sbjct: 1 MKIIAYGARVDEIQYFKQWAKDTGNTLEYHTEFLDENTVEWAKGFDGINSLQTTPYAAGV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E++ +G+K++ +R G +N+D+ A K+ G+++ VPAY P A+AE A+ + L R + Sbjct: 61 FEKMHAYGIKFLTIRNVGTDNIDMTAMKQYGIRLSNVPAYSPAAIAEFALTDTLYLLRNM 120 Query: 121 HRAYQRTRDANFSLEG-LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + + + ++ G G + +T GV+GTG IG +++ KGFG +++A+DPYP Sbjct: 121 GKVQAQLQAGDYEKAGTFIGKELGQQTVGVMGTGHIGQVAIKLFKGFGAKVIAYDPYPMK 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 +YV L LF +SDVI LH P +N H++NEAAF MK G +++NT+R LID Sbjct: 181 GDHP-DFDYVSLEDLFKQSDVIDLHVPGIEQNTHIINEAAFNLMKPGAIVINTARPNLID 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 +QA + LK+ K+ +G+D YE E + + +D ++ L NV+ + H A+ Sbjct: 240 TQAMLSNLKSGKLAGVGIDTYEYETEDLLNLAKHGSFKDPLWDELLGMPNVVLSPHIAYY 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T A+ ++ +LQ+L + E+ Sbjct: 300 TETAVHNMVYFSLQHLVDFLTKGETSTEV 328 >UniRef50_C7H518 Glycerate dehydrogenase n=3 Tax=cellular organisms RepID=C7H518_9FIRM Length = 320 Score = 349 bits (898), Expect = 6e-95, Method: Composition-based stats. Identities = 85/329 (25%), Positives = 145/329 (44%), Gaps = 23/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGF-ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK + + ++ L + + E+ A + + + + Sbjct: 1 MKAVILESYVMEEGDLDWSGVKALVPDTVSYVRTAYEEIAPRIGDAD-IVLLNKCRMNEE 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +L++ +K++ + G +N+DL+A + G+ V VP Y +VA+ +++ + + Sbjct: 60 ILQQCP--NLKWVGIIATGTDNLDLEACRRHGVAVANVPGYSTYSVAQMTFSLLLAICQC 117 Query: 120 IHRAYQRTRDANFSLE------GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 R + + + L+ L + GKT GV G G IG RI + FGM +L Sbjct: 118 AERYNRAVKQGCWQLDIPESIGLLPQMELCGKTYGVYGYGSIGRQSARIARAFGMEVLVC 177 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 GVE+VD TL D++SLHCP TP+ L+N A +MK G +++NT+ Sbjct: 178 TRTVRPEYAADGVEFVDYDTLLRRCDILSLHCPATPQTRGLVNAEALAKMKPGAILLNTA 237 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RGAL+D +A AL + ++G G D + E L A + + T Sbjct: 238 RGALVDEEAVAAALHSGQLGFYGADAFVTEPL-------------PQESPLRAEPHAILT 284 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGE 322 H A+ T EAL ++ T +NL +G Sbjct: 285 PHIAWTTREALQNLMDITTRNLRTWLEGN 313 >UniRef50_Q54UF7 Putative D-lactate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=LDHD_DICDI Length = 340 Score = 349 bits (898), Expect = 6e-95, Method: Composition-based stats. Identities = 149/331 (45%), Positives = 220/331 (66%), Gaps = 3/331 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ ++S+K Y K+ ++N+ F +E+ + K+ A G EAVC FVNDD S+ V Sbjct: 1 MKITLFSSKPYWVKWFNELNK-FSYEINYVTSACDIKSVNEAKGSEAVCCFVNDDLSKEV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E L +G K I +RCAGFN VDLD A +LG+ V+RVPAY P AV+E+A+ ++M LNR+ Sbjct: 60 IETLHSNGTKVILMRCAGFNKVDLDTANKLGIPVLRVPAYSPNAVSEYALSLIMALNRKT 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSA 179 H+A+ R RDANF + G+ GF M K G++GTG IG + R+LK GFG +++A+D + Sbjct: 120 HKAHDRVRDANFEINGMEGFNMVSKVYGIVGTGNIGEQLCRVLKLGFGAKVIAYDIIENK 179 Query: 180 AALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 A ++G+EYV L ++ + DVISLH PL + +++N + E+M++GVMI+N SRGAL+ Sbjct: 180 AVTDIGIEYVKTLDEIWKQCDVISLHTPLNSQTKYMVNSESIEKMRDGVMIINVSRGALV 239 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ AI LK+ KI SLGMDVYENE D F++D + +I+DD L + NV+ T HQA+ Sbjct: 240 NASDAIVGLKSGKISSLGMDVYENETDYFYQDHNGSIIKDDNLSLLISYPNVMITSHQAW 299 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNELV 329 T EA++ I T+LQN + + + LV Sbjct: 300 YTKEAISCICGTSLQNFVDFRSNQIKKSNLV 330 >UniRef50_B5HCN2 D-lactate dehydrogenase n=6 Tax=Streptomyces RepID=B5HCN2_STRPR Length = 335 Score = 349 bits (896), Expect = 9e-95, Method: Composition-based stats. Identities = 142/329 (43%), Positives = 188/329 (57%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + +K +++ + D L TA A G E + VN V Sbjct: 1 MEILAFGVQADEKPLIEKAFADLPGGVRCLDVFLDADTAAIAAGHEVISTSVNAQLDAEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L L G + IA R GFNN+DL+ A+ LGL V RV Y P +VAE A + M +NRR+ Sbjct: 61 LRTLAVGGTRMIAQRSTGFNNIDLEVAERLGLTVARVSYYSPYSVAEFAWTLTMAVNRRV 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA RTRD +F L+GL G M G+TAGVIGTGKIG A RI GFGMRLL D P+ Sbjct: 121 VRAANRTRDFDFRLDGLMGRDMRGRTAGVIGTGKIGEAFTRIAHGFGMRLLGLDVAPNPV 180 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +ELG+EYVD L + +D++SLH PL P HL+ MK+ ++VN+SRG LIDS Sbjct: 181 CVELGMEYVDKDELLAAADLVSLHVPLMPATRHLIGARELRAMKDDAILVNSSRGGLIDS 240 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A + L+ + +G+DVYE E LFF DKS + + DD RL NVL T HQA+ T Sbjct: 241 DALVGELRKGRFSGVGLDVYEAEAGLFFLDKSMEAVDDDTLARLMTFPNVLVTSHQAYYT 300 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 A+A+T I TT +N+ +G N LV Sbjct: 301 ADAVTQIVDTTARNIKAHLEGRRGENVLV 329 >UniRef50_Q0SVM3 D-lactate dehydrogenase n=31 Tax=Bacteria RepID=Q0SVM3_CLOPS Length = 332 Score = 349 bits (896), Expect = 9e-95, Method: Composition-based stats. Identities = 116/330 (35%), Positives = 187/330 (56%), Gaps = 4/330 (1%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 KL Y ++ + Y ++NE FG++L + L + + A G EA+ + N R L Sbjct: 3 KLVCYGVRETEVPYFHKLNEEFGYDLTLVEKNLNHENVEEAIGAEAIMVRGNCMADRQNL 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E LK G+KY+ R GF++VDL+AAK+LGL+V RVP Y P A+ E A+ + M L R Sbjct: 63 ELLKSKGLKYVLTRTVGFDHVDLEAAKDLGLQVARVPGYSPNAIGELAVSLAMMLLRHTA 122 Query: 122 RAYQRTRDANFSLEGLT-GFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RT + NF ++G + T G++G G+IG+ ++ KG G +++A+D + S A Sbjct: 123 YTTHRTSNKNFVVDGFMFSKEIRNCTVGILGAGRIGLTTAKLFKGLGAKVVAYDVFQSDA 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTP-ENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A E+ VE++ L + SDVIS+H P +NYH++NE +MKN +I+NT+RG L D Sbjct: 183 AKEI-VEFMPLDEVLKVSDVISVHMPYIKGQNYHMINEEFISKMKNDAIIINTARGELQD 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSAC-HNVLFTGHQAF 298 +A ++AL+ ++G G DV E E +FF++ ++++ + +L + L T H Sbjct: 242 IEAIVKALEEGRLGGFGTDVLEGESAVFFKNLEGQKLENESYEKLISLYPRALVTPHMGS 301 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EAL ++ + +NL + TC N + Sbjct: 302 YTDEALRNMIGISYENLKEYLEKNTCKNAI 331 >UniRef50_A3MTB6 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=4 Tax=Archaea RepID=A3MTB6_PYRCJ Length = 334 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 81/342 (23%), Positives = 146/342 (42%), Gaps = 30/342 (8%) Query: 2 KLAVYSTKQ--YDKKYLQQVNESFGF-----ELEFFDFLLTEKTAKTANGCEAVC--IFV 52 K+ V S K + + + +G E+ F E+ + + V Sbjct: 5 KIVVLSPAPEALLKMWATPIAQKYGIAIDEVEVVTFFEPNYEEIGRHVADADVVVGDYTF 64 Query: 53 NDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGM 112 + E++ K V+ I G++++D++A G+ V + + +VAEH I + Sbjct: 65 RIKIDASLCEKMSK--VRLIQQPSTGYDHIDVEACARRGIPVANIGGANAISVAEHTIML 122 Query: 113 MMTLNRRIHRAYQRTRDANFSLEGLTGF--TMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 + L +R A++R + ++ L ++GKT GV+G G+IG + G ++ Sbjct: 123 ALMLLKRAVYAHRRLLEGQWTQGELMNVIGEVFGKTWGVLGMGRIGREVAVRAMALGAKV 182 Query: 171 LAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + +D + + G EY L +ESD++S+H PLTP ++ E MK +++ Sbjct: 183 IYYDVVRNEEMEKRGAEYRPFNRLLAESDILSIHVPLTPATRKMIGERELRLMKPTAVVI 242 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH-- 288 N SRG ++D +A +A++ I G+DV+ E L Sbjct: 243 NVSRGEIVDEEALAKAVREGWIAGAGVDVFSVEPP-------------PPDHPLIQAARE 289 Query: 289 --NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 NV+ T H A T EA I +L+N+ + G N + Sbjct: 290 GYNVVVTPHIAGATNEARMRIINVSLENVFKVLAGLKPDNVV 331 >UniRef50_A4YFM2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YFM2_METS5 Length = 324 Score = 347 bits (891), Expect = 4e-94, Method: Composition-based stats. Identities = 88/335 (26%), Positives = 150/335 (44%), Gaps = 28/335 (8%) Query: 1 MKLAV-----YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDD 55 MK V ++ D++ ++++N + F + ++ A+ Sbjct: 1 MKPVVGIDSSVIVEELDQEKVRELNSLAEI-VYFNPYAPEDQIVSLLRDAIAIVDR-KAK 58 Query: 56 GSRPVLEELKKHGVKYIALRCAGFN--NVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 S ++ EL +K IA AG + VDL AAKE + + P + AVAE I + Sbjct: 59 ISSKIIREL--RNLKLIARTGAGVDETRVDLKAAKERDIIITYNPGGNSVAVAELTIMLA 116 Query: 114 MTLNRRIHRAYQRTRDANFS---LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 + L R++ + +S + G + GK G++G G IG + +++ ++ Sbjct: 117 IALYRKVIPLALSVKAGKWSELKPKDTMGHELEGKAWGILGFGNIGKRVAQLVTSLNCKV 176 Query: 171 LAFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMI 229 L +DPY S+ +E GV+ + L L S+SD+IS+H PLT HL+N + MK ++ Sbjct: 177 LGYDPYVSSEIMEKHGVKSLSLEELLSKSDIISIHVPLTESTRHLINSERLKTMKKTAIL 236 Query: 230 VNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHN 289 +N SRG +ID +A E+L+N +I +D E E V L + N Sbjct: 237 INVSRGGIIDDKALYESLRNGEIAGAALDTPEEEPVK-------------VDNPLLSLDN 283 Query: 290 VLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 V+ T H T EA + + ++ + KG Sbjct: 284 VIITPHIGGSTFEASIKNANSAVEEVIRFLKGLPP 318 >UniRef50_A5N5A9 SerA n=3 Tax=Clostridium RepID=A5N5A9_CLOK5 Length = 320 Score = 347 bits (891), Expect = 4e-94, Method: Composition-based stats. Identities = 80/331 (24%), Positives = 149/331 (45%), Gaps = 20/331 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + T+ +++ ++ + FG+E++ + + C+A+ + + + + V Sbjct: 1 MSYKILITESIEEEGVE-YLKKFGYEIKMPRDTSEDVLIEEVKDCDAILVRMAN-ITEKV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 + KK +K I+ G NNVD+ A EL +++ P + VAE+ +G+++ L ++ Sbjct: 59 IRAGKK--LKVISRFGVGVNNVDIKTASELSIQITNAPESNKNTVAEYTMGLIIALAKKF 116 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 + R NF + + G + GK G++G G IG + KGFGM+++ F + Sbjct: 117 FLYDRGLRKGNFKVRDILGIDLEGKVLGIVGLGSIGKLLALKASKGFGMKVIGFKRHIDE 176 Query: 180 AALELG-VEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + L VE D L + SD +SL+ PLT ++ + MK ++NT+RG + Sbjct: 177 ESKSLDYVELTDSLDYVLENSDFVSLNVPLTKATTKIIGKRELSFMKKDAFLINTARGEV 236 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D+ A AL N++I DV++ E + NV+ T H A Sbjct: 237 VDNDALCNALLNKQIAGAATDVFDGEIPSK-------------DNPIFKMENVIVTPHSA 283 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA+ +S + + G + Sbjct: 284 AHTIEAMKRMSVHAAIGIHEVLSGNKPSWPV 314 >UniRef50_A3CQK1 Glyoxylate reductase, NADH-dependent, putative n=10 Tax=Bacteria RepID=A3CQK1_STRSV Length = 318 Score = 347 bits (891), Expect = 4e-94, Method: Composition-based stats. Identities = 87/332 (26%), Positives = 149/332 (44%), Gaps = 23/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V T K+ L ++ E + + + + +A + G + ++ Sbjct: 3 KKKVLVTGIVPKEGLVKLMEKYDVTYSDGEPFSRDYVLEHLPEYDAWLLMGQ-KGDKEMI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + K ++ I+L GF++VD++ AK+ G+ V P AE +++ +R+ Sbjct: 62 DAGK--NLQIISLNAVGFDHVDIEYAKQKGIVVSNSPQAVRVPTAEMTFALLLAATKRLA 119 Query: 122 RAYQRTRDANF---SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-- 176 + R N+ S G T+ G T G+ G G+IG + K FGM++L D Y Sbjct: 120 FYDKIVRTGNWIDPSERRYQGLTLEGATLGIYGMGRIGSTVAGFAKAFGMKVLYHDLYRL 179 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 P ELGV YV+ L ++DVI++H P P +H N+ F++MKN ++N +RG Sbjct: 180 PEEREKELGVSYVEFDDLVEKADVITIHAPSLPSTHHKFNKEVFKKMKNRSYLINAARGP 239 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 ++ + IEALK +I G+DV+E E +V L A NV+ H Sbjct: 240 IVSEEDLIEALKTGEIAGAGLDVFEFEP--------------EVSEELRALDNVIMAPHA 285 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E +++ N+ + +G N + Sbjct: 286 GTGTIEGRRTLAAEAAANILSFFEGN-PVNVV 316 >UniRef50_B3SAF7 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3SAF7_TRIAD Length = 324 Score = 346 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 81/340 (23%), Positives = 146/340 (42%), Gaps = 37/340 (10%) Query: 5 VYSTKQYDKKYLQQVNESFGFELE---FFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 VY T+ + ++ + G + D + ++ GC+A+ + D + VL Sbjct: 4 VYVTRCLPEDSA-RLLQKDGINVVMRSTDDAIPRQELLDNIPGCDALICMLTDKVDKDVL 62 Query: 62 EELKK----------HGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIG 111 + K +K IA GF+++DLD K+ + V P +AVAE + Sbjct: 63 DAAGKHDTKLNHLTSPSLKVIATVSVGFDHIDLDECKKRNIVVSNTPRVSTDAVAELTVA 122 Query: 112 MMMTLNRRIHRAYQRTRDANFSLEGLT---GFTMYGKTAGVIGTGKIGVAMLRILKGFGM 168 +++ +RR+ ++ ++ GL G + G T G+ G G+IG+A+ L+ FG+ Sbjct: 123 LLLATSRRLMECANAVKNGDWKSWGLLWMCGTELRGSTVGIFGLGRIGIAIATRLQCFGV 182 Query: 169 RLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVM 228 + + + V V++ L D I ++C LTPE L NE AF +MKN + Sbjct: 183 KQFYY-------TDIVEVPQVEIEDLLKSCDFIIINCALTPETAGLFNEKAFAKMKNNCV 235 Query: 229 IVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH 288 +VN +RG +I+ + +AL + I G+DV + E L + Sbjct: 236 LVNAARGGVINQKDLYQALVSGAIKGAGLDVTDPEPMAK-------------DDPLLTLN 282 Query: 289 NVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 N + H T E T ++ + N+ + G+ + Sbjct: 283 NCVVLPHIGSNTMETRTEMASLAVNNVLAVLDGKPLLTPV 322 >UniRef50_Q03YV3 Lactate dehydrogenase related enzyme n=2 Tax=Leuconostoc RepID=Q03YV3_LEUMM Length = 314 Score = 346 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 85/329 (25%), Positives = 150/329 (45%), Gaps = 21/329 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M V+ +++ E G E+ EK AV I + Sbjct: 1 MTKQVFLPDDIPAVG-KKILEEAGLEVVVGSGRDHEKMKAEGVEASAVLI-GTQKFDADI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ + +K IA G++ VD+DAA + G+ VV P +VAE A+ ++ +++ + Sbjct: 59 MDAMP--NLKVIARNGVGYDAVDVDAATQRGIYVVNTPKALSGSVAETAVSELLAISKNL 116 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 ++ + D N++ + G + GKT G++G G+IG + + L GF ++++AFDP+ Sbjct: 117 YQDSKAIHDDNWNYRKAHPGRDIEGKTVGILGFGRIGQQVAKKLSGFDVKVIAFDPFAKD 176 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 GVE VD T+F +D + +H P PE H + F+ MKN ++N +RG+++ Sbjct: 177 V---PGVELVDRETIFKTADYVMVHLPALPETQHSIGADEFKLMKNDAFLINMARGSILV 233 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + ALK+ +I +DV+E E V L A NVL T H A Sbjct: 234 ESDLVLALKSGEIAGAALDVFEEEPL-------------PVTNPLVALENVLLTPHIASN 280 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E ++ ++ + G+ + + Sbjct: 281 TVETKARMAVDATNDIVRVLSGKNPESAV 309 >UniRef50_C4Z227 D-lactate dehydrogenase n=1 Tax=Eubacterium eligens ATCC 27750 RepID=C4Z227_EUBE2 Length = 328 Score = 346 bits (889), Expect = 7e-94, Method: Composition-based stats. Identities = 119/330 (36%), Positives = 198/330 (60%), Gaps = 5/330 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAV-CIFVNDDGSRP 59 MK+A +S +Q +K+Y + EL+ T ++ GCEA+ D S P Sbjct: 1 MKIAAFSVRQDEKQYFDTFANVYKVELQINRSGFTADDIESVKGCEAMSVCDGMCDLSAP 60 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VLE+L GVKYI R G+N+VDL+AAK LG++V Y P +VA + + +M+ R+ Sbjct: 61 VLEKLAAEGVKYIGFRTIGYNSVDLEAAKRLGIRVAHS-GYSPYSVANYTVMLMLMCIRK 119 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 R+ A++SL + G M T G+IGTG+IG A+++ L GFG +++A+DPYP+ Sbjct: 120 ALYVMMRSHTADYSLGPICGREMQNMTVGIIGTGRIGKAVIKNLSGFGCKIIAYDPYPAK 179 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 VEYV L L++ +D+ISLH L+ E YH++N+ + +MK+GV+++N +RGAL+D Sbjct: 180 DLE--NVEYVTLDELYARADIISLHTFLSDETYHMINKDSIAKMKDGVILINAARGALVD 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKS-NDVIQDDVFRRLSACHNVLFTGHQAF 298 ++ IEA+++ KIGS+G D E E + D+ +D++ + + L + N + T H AF Sbjct: 238 TKDLIEAVESGKIGSVGTDCCEGEDEFIRTDRKYDDLVVNHDYIILKSFQNTIVTPHVAF 297 Query: 299 LTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T +A++ + +++++++ GE P E+ Sbjct: 298 FTDQAVSDMVESSVKSVVQFAAGEDTPLEV 327 >UniRef50_Q9BLF6 D-lactate dehydrogenase n=1 Tax=Octopus vulgaris RepID=Q9BLF6_OCTVU Length = 324 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 95/333 (28%), Positives = 161/333 (48%), Gaps = 24/333 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDF---LLTEKTAKTANG--CEAVCIFVNDD 55 M VY T++ + E G E++F+D + ++ K G + + D Sbjct: 1 MANKVYITRRIPPVGIDLFREK-GVEIDFWDSDEAIPHQELVKNVKGKGYAGLLCLLTDQ 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 V E +K ++ G+ ++DL A K + + + V+E A+ + + Sbjct: 60 VDAEVFEAAG-PSLKVVSTLSVGYEHIDLKACKARNIIACNLSKISTDCVSEFAVTLALA 118 Query: 116 LNRRIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGM-RLL 171 ++RRI R+ ++ L + G + +T GV+G G+IG + R +K F + RL+ Sbjct: 119 VSRRIEEGIAAVRNGSWGLWKPMWILGSSFANRTIGVLGMGRIGYGVARRMKAFCISRLI 178 Query: 172 AFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVN 231 D S+ A ELG E+VDL TL +SDVI + C LTP ++L N+ F++MKN +++N Sbjct: 179 YHDIKESSFAQELGAEFVDLETLLKDSDVICICCNLTPATHYLFNKENFKKMKNTAILIN 238 Query: 232 TSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVL 291 TSRG +I+ +ALKN +IG+ G+DV E E RL++ N + Sbjct: 239 TSRGGVINHDDLYDALKNHEIGAAGLDVTEPEPL-------------PKEHRLNSLPNCV 285 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 T H T EA ++S N+ ++ + +T Sbjct: 286 VTLHMGSNTWEARNNMSYNAALNIDSVFENQTP 318 >UniRef50_D1CGN8 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CGN8_THET1 Length = 319 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 91/322 (28%), Positives = 148/322 (45%), Gaps = 26/322 (8%) Query: 12 DKKYLQQVNESFGFELEFFD---FLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHG 68 D +++Q+ E G E+ E+ + +A+ D+ + V+E + Sbjct: 20 DPSHIRQL-EEAGCEVVPNSLGRAYREEELLELLPEMDAII-TGTDELTARVIEAAGR-- 75 Query: 69 VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTR 128 ++ IA G +N+DL+AA+ G+ V P ++VA+ +G+++ + R+I A+ T Sbjct: 76 LRTIAKHGVGLDNIDLEAARRRGIVVTATPGAIHDSVADLTMGLIIAVARQIVPAHNSTV 135 Query: 129 DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVE 187 + G + KT G+IG G+IG + FGMR++A+D YP A GV Sbjct: 136 AGEWR--NFVGLELRDKTLGIIGLGRIGKGVCLRALPFGMRVVAYDLYPDEEFARAHGVR 193 Query: 188 YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEAL 247 +V L L + SDV++LH + LL MK G + +NTSRG L+D A EAL Sbjct: 194 FVGLEELLATSDVVTLHASAGNDGR-LLGRREIGLMKPGAIFINTSRGKLVDEGALCEAL 252 Query: 248 KNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSI 307 ++ G+DV+E E L NV+ T H A T E + + Sbjct: 253 AVGRLAGAGLDVFEEEPPRG---------------PLLELPNVVLTPHIAGQTREGMIRM 297 Query: 308 SQTTLQNLSNLEKGETCPNELV 329 + T+QN +GE +V Sbjct: 298 GEMTVQNCLRALRGEEPLYRVV 319 >UniRef50_A4S3N1 Predicted protein n=2 Tax=Ostreococcus RepID=A4S3N1_OSTLU Length = 380 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 143/337 (42%), Positives = 205/337 (60%), Gaps = 16/337 (4%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 + V+S +Y+ + L++ + + L+ TA A G +AVC+FV+DD V+ Sbjct: 40 RCFVFSAHRYEDETLRRALPNA----TYSSARLSLDTASLAQGHDAVCVFVDDDARGEVV 95 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 + L + GVK I LRCAGF+NVD + A+E G+ V+RVPAYDP +++EHA+ MMM+LNR + Sbjct: 96 DALAERGVKLILLRCAGFDNVDCERARERGISVLRVPAYDPLSISEHAVAMMMSLNRHLC 155 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAA 180 + R R NF+L+GL G +M GKT GV+GTGKIG + ILK GF MR+L +D + Sbjct: 156 ASRDRLRMGNFTLDGLVGSSMRGKTVGVVGTGKIGRGVAEILKNGFQMRVLGYDKFEKDD 215 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 YV L L + SDV+SLH PLTPE ++ +MK G +++NTSRG L+D+ Sbjct: 216 FCGD---YVSLDELLARSDVVSLHLPLTPETRGMICVETIAKMKEGTILINTSRGLLVDA 272 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSN------DVIQDDVFRRLSACHNVLFTG 294 +AAI+ L + +I +LG+DVYENE LFF+D S+ ++ D+ L + VL T Sbjct: 273 RAAIDGLYSGRIAALGLDVYENENRLFFKDFSSMNTNERMLVWDETMAILGSMPQVLVTP 332 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCP--NELV 329 H AFLT EAL I++ T +N GE N +V Sbjct: 333 HTAFLTHEALDEIAKHTAENFRQFCAGERLEGANVVV 369 >UniRef50_Q8EMM3 Dehydrogenase n=5 Tax=Bacteria RepID=Q8EMM3_OCEIH Length = 329 Score = 346 bits (888), Expect = 9e-94, Method: Composition-based stats. Identities = 85/332 (25%), Positives = 141/332 (42%), Gaps = 22/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + + + + + E G E V I +R V+ Sbjct: 5 KVLITDCDHGNVDVESETFKKAEISFDLEQCKTEEDLISKGKGFE-VFINQYAPVTRSVI 63 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E L +K + G +NVD+ AA E G++V VP Y VA+ A+ MM+ R I Sbjct: 64 ENLPD--LKLVVRYGVGVDNVDIAAATEHGVQVCNVPDYGMNEVADQALAMMLNFTRSIS 121 Query: 122 RAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP-YPSA 179 R R + + + + +T GVIG G+IG + + +K G R++A+DP Y Sbjct: 122 RMNSFVRKGVWDYQKSMPLYRHSEQTVGVIGVGRIGSSFAKKVKSLGCRVVAYDPKYLDE 181 Query: 180 AAL---ELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A + E++ L L ++DV+S+HCPL +L++E ++MK ++N SRG Sbjct: 182 KAKKSPDFIDEFLPLNELLEQADVVSIHCPLDKA-RNLIDEKELQKMKPTAYLINVSRGG 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +I+ QA +AL NQ I +DV ENE L N + T H Sbjct: 241 IINEQALNKALTNQWIAGAAVDVAENEPLQ-------------PESALLEHDNFICTPHM 287 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + + +A + + + G+ + Sbjct: 288 GWYSEQAALELKRKVAEESIRHLNGDQVHYPI 319 >UniRef50_A9BJ57 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=5 Tax=Thermotogaceae RepID=A9BJ57_PETMO Length = 310 Score = 345 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 88/320 (27%), Positives = 151/320 (47%), Gaps = 19/320 (5%) Query: 1 MKLAVYSTKQYDKKYLQQV-NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ + D+ L+++ NE E+ + L + + + + ++ Sbjct: 1 MKIHI--NDPLDENALKKLQNELPDLEIT-SEHLEKDVLKDKIKEIDVLIVRSATKVTKE 57 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE K +K +A G +N+D+D AK G+ V+ P + +VAE IGM++ + R Sbjct: 58 ILEHADK--LKIVARAGMGLDNIDVDTAKLKGITVLNTPGQNSLSVAELVIGMVLDIYRH 115 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP-- 177 I R ++ + + L GF + KT G+IG G +G + ++LKGF L +D + Sbjct: 116 ITRGTIGLKNEQWEKKQLEGFELSQKTFGIIGFGYVGKNLAQLLKGFQTNTLVYDVFEIS 175 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + V V L L SD+ISLH P + YH ++E + MK+G +I+N +RG + Sbjct: 176 AEEQKNYNVRQVSLEELLQNSDIISLHIPKNEKTYHFISEPQIKMMKDGAVIINAARGGV 235 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D ++ LKN K+ +G+DV+E E D ++ L A NV+ T H Sbjct: 236 LDENYVLKYLKNGKLLGVGLDVFEEEPPKG-----------DFYKELFALPNVVLTPHIG 284 Query: 298 FLTAEALTSISQTTLQNLSN 317 T EA + + + Sbjct: 285 ASTKEAQERVGINIVDRVVE 304 >UniRef50_D1PMF0 D-lactate dehydrogenase n=1 Tax=Subdoligranulum variabile DSM 15176 RepID=D1PMF0_9FIRM Length = 328 Score = 345 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 119/329 (36%), Positives = 194/329 (58%), Gaps = 4/329 (1%) Query: 1 MKLAVYSTKQYDK-KYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ Y+ + +D+ +Y + E +G + ++ + + T + + A GC+AV + Sbjct: 1 MKILFYALRPFDELQYCEPNREKYGIDYKWTEEVPTPENLQLAEGCDAVS-TNPCEVRPE 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 LE K GVKY+ R G++++ LDAAK LGL+V Y PE VA + I +M+ R+ Sbjct: 60 YLEAFAKMGVKYLPCRSIGYDHIPLDAAKRLGLRVSHS-HYPPEGVANYTIMLMLMATRK 118 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 +++ R ++SL G G + T GVIGTGKIG ++R L GFG ++LA+D YPS Sbjct: 119 MNQIMVRAAAQDYSLPGKMGHDLSSCTVGVIGTGKIGSTVIRHLSGFGCKILAYDLYPSD 178 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A EYV L L++ SDVI+LH TPEN+HL+N A +MK+GV++VNT+RG LID Sbjct: 179 AVRPY-AEYVSLNELYARSDVITLHLNATPENHHLINAEAITRMKDGVLLVNTARGTLID 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 S++ ++ L++ KIG G+DV E+E + + ++ + + + L + NV+ + H AF Sbjct: 238 SESLLQGLESGKIGGAGLDVVEDENGICYYNRCGEALPNRELNLLRSYPNVILSPHTAFY 297 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T + S+ Q+ + +++ G + P E+ Sbjct: 298 TDVNVASMVQSAFEAVADFAAGRSNPCEV 326 >UniRef50_Q6RK69 D-lactate dehydrogenase n=4 Tax=Lactobacillus RepID=Q6RK69_9LACO Length = 331 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 106/331 (32%), Positives = 180/331 (54%), Gaps = 4/331 (1%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MKL VY+ + + ++++ E+ L +TA A G + V S+ + Sbjct: 1 MKLIVYNVRDDEIPFVEKWGRDHQIEVTTTTTTLNTETAAEAAGFDGVSCLQTIPYSKEL 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++ G+ Y+ALR G +N+D+ AAK +K+ VPAY PE++AE A+ M + L+R++ Sbjct: 61 FAALQRLGIHYLALRNVGTDNIDIQAAKANNVKITNVPAYSPESIAEFAVMMALYLSRKV 120 Query: 121 HRAYQRTRD-ANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 Q+ ++ F G + +T GVIGTG+IG +++ +G G ++A+D YP Sbjct: 121 GYMQQQLQEQHEFHFSPAFMGRLISEQTVGVIGTGRIGRHAIQLFRGLGANVIAYDKYPQ 180 Query: 179 AAALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +YVD L + +SD+ISLH P T +N+HL N FE+MK +++NT+RG + Sbjct: 181 KITGGA-FKYVDHLEDIIKQSDIISLHMPATADNFHLFNHEVFEEMKPNAILINTARGTI 239 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D+ I AL++ +I + G+D E+E + +S I D +LS NV+ T H A Sbjct: 240 VDTNDLIFALESGEIAAAGIDTLEDESIDLQDSRSTKKITDADLIKLSMMPNVILTPHSA 299 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 F T E++ ++ +L NL + +G + + Sbjct: 300 FHTTESVKNMVNISLNNLKTMAEGGKPADLV 330 >UniRef50_P40054 D-3-phosphoglycerate dehydrogenase 1 n=76 Tax=cellular organisms RepID=SERA_YEAST Length = 469 Score = 345 bits (886), Expect = 2e-93, Method: Composition-based stats. Identities = 89/323 (27%), Positives = 148/323 (45%), Gaps = 12/323 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK-TAKTANGCEAVCIFVNDDGSRP 59 MK+ + + ++ + + E G+++EF+ L E+ + A+ I + Sbjct: 59 MKILLL--ENVNQTAI-TIFEEQGYQVEFYKSSLPEEELIEKIKDVHAIGIRSKTRLTSN 115 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VL+ K + I C G N VDLD A G+ V P + +VAE I +++L R+ Sbjct: 116 VLQHAK--NLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELVIAEIISLARQ 173 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + ++ + + GKT G+IG G IG + + + G+ +L +D Sbjct: 174 LGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGLHVLYYDIV--- 230 Query: 180 AALELG-VEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + LG V L L ++SD ++LH P TPE +L+ F MK+G ++N SRG + Sbjct: 231 TIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAYVINASRGTV 290 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D + I+A+K KI +DVY +E E ND + + L + N++ T H Sbjct: 291 VDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDEL-NSWTSELVSLPNIILTPHIG 349 Query: 298 FLTAEALTSISQTTLQNLSNLEK 320 T EA +SI LS Sbjct: 350 GSTEEAQSSIGIEVATALSKYIN 372 >UniRef50_A8MCX1 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=6 Tax=Thermoproteaceae RepID=A8MCX1_CALMQ Length = 317 Score = 344 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 90/316 (28%), Positives = 154/316 (48%), Gaps = 17/316 (5%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELK 65 T + D++ + +++E G +++ + E+ K + + + +R V++ Sbjct: 12 LITDKIDERLINKLSE-MGVAVDYKPGIQHEELLKIVENYDILVVRSRTKVTREVIDRGA 70 Query: 66 KHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQ 125 +K IA G +N+D+D A + GL +V P + AE + +M+ ++R +H Sbjct: 71 --SLKIIARAGVGLDNIDVDYALKRGLTIVNSPNAATYSAAELTLSLMLIISRNLHLHLI 128 Query: 126 RTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY-PSAAALEL 184 ++ +S G + GKT GV+G G+IG A+ K GMR+LA D S A EL Sbjct: 129 DVKNGKWSKGLYHGIELRGKTLGVVGFGRIGRAVANYAKALGMRILATDVVDISRYAEEL 188 Query: 185 GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAI 244 G V L L S SDV++LH L E YH+LN+ + +K+ +IVNTSRG +ID++A + Sbjct: 189 GASVVSLTELLSRSDVVTLHVALNKETYHMLNDDRLKLIKDNAIIVNTSRGEVIDTKALL 248 Query: 245 EALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEAL 304 L ++ +G+DV E+E ++D +L V+ T H T +A Sbjct: 249 NHLD--RLWGVGLDVLEHEPP-----------REDWEIKLIQHPKVVVTPHIGAETIDAQ 295 Query: 305 TSISQTTLQNLSNLEK 320 I + N+ + Sbjct: 296 GRIVDELVFNIQEALE 311 >UniRef50_C0QZF2 Lactate dehydrogenase-like dehydrogenase n=2 Tax=Brachyspira RepID=C0QZF2_BRAHW Length = 331 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 173/329 (52%), Gaps = 2/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + VYS + ++ + + + + + L K A G ++V D + V Sbjct: 1 MSIVVYSFLDDESEFFKLMEKKYNTKFTLHKHHLNIDNVKDAEGFDSVVFNARDAITSEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++LK++GVKY++ R G++N+D+D A ++G+K+ VP+Y P +V+E I ++++ + Sbjct: 61 LDKLKEYGVKYMSTRSVGYDNIDIDYANKIGIKIANVPSYSPNSVSEFTILSLLSIVKNY 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMR-LLAFDPYPSA 179 + + N++ GL + GVIGTG+IG ++ LKGF + + + Sbjct: 121 NNLLINGYNRNYTRTGLVAKEIRNLNIGVIGTGRIGSLTVKHLKGFSPKNIFVYSRTEKE 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 + +YV L L+ SD I H P E +++ + + +MK GV I+N SRG +++ Sbjct: 181 EIKQY-AKYVSLDELYKNSDAIIYHIPYNKETENMICKDSINKMKKGVYIINVSRGGIVN 239 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++ ++ LK+ IG +DVY NE + ++ + V++D++ L NV+ T H AF Sbjct: 240 NKDLLDGLKSGHIGGAALDVYTNEIEYVNKNIKDIVLKDEIIEELFKMDNVIITPHFAFY 299 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EAL ++ ++ N+ + C N++ Sbjct: 300 TDEALLNMVSISIDNIFEFKNTGKCVNQI 328 >UniRef50_B1ZP48 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=4 Tax=Verrucomicrobia RepID=B1ZP48_OPITP Length = 326 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 84/314 (26%), Positives = 143/314 (45%), Gaps = 20/314 (6%) Query: 18 QVNESFGFELEFFDFLLTE-KTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRC 76 + G+E+ L E T + +D +R VLE+ + +K ++ Sbjct: 20 DLLAQTGWEVIRARGPLNEADTLALVGEVDGYIC-GDDAITRQVLEKA-RPRLKVLSKYG 77 Query: 77 AGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEG 136 G + +D+ + E G+ ++ P + VAEH +++ L + TR + + Sbjct: 78 IGVDKIDVKSCTEFGIPLLFTPGVNHTTVAEHTFLLLLALEKNFLFHTDSTRSGGWKRK- 136 Query: 137 LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALELGVEYV-DLPTL 194 TG + KT G++G G+IG + K FGM + +D Y A E GV+ V L + Sbjct: 137 -TGHELLEKTIGIVGLGRIGKEVAIRAKAFGMTPIGYDVYWDDKFAAEHGVKRVNSLDEI 195 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 F+ SD +SLH LTP+ ++N AAF +MK GV+I+N +RG ++++ + ALK+ ++G Sbjct: 196 FAASDYLSLHTNLTPQTRGMINAAAFAKMKKGVLILNCARGEIVNTADMVAALKSGQVGG 255 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 G DV + E L NV+ T H T E++ + + N Sbjct: 256 YGTDVLDQEPPA-------------ADHPLLKLPNVVCTPHIGSRTYESVVRQATAAVTN 302 Query: 315 LSNLEKGETCPNEL 328 L GE ++ Sbjct: 303 LIRAMHGEKPLAQV 316 >UniRef50_UPI00016C495D phosphoglycerate dehydrogenase n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C495D Length = 539 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 79/326 (24%), Positives = 138/326 (42%), Gaps = 18/326 (5%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 V + + ++ + ++ G E++ L ++ +AV S + Sbjct: 4 VLIADKLESSGIE-LLQAAGIEVDNRPGLKGDELKAAIQAADAVICRSQPKLSAEYFDNP 62 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K ++ +A G +N+D+ AA G+ V+ P + + AEH I +++ L+RRI A Sbjct: 63 GK--MRAVARAGVGVDNIDVAAATRKGVVVMNTPGGNTVSAAEHTIALLLALSRRIPAAD 120 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-ALE 183 + + G + GK GV+G G+IG + R KG M+++A D + +AA E Sbjct: 121 ATMKAGGWDRNKFVGTEVAGKVLGVVGLGRIGREVARRAKGLDMKVIALDQFVTAAKVAE 180 Query: 184 LGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQA 242 LG E L L + D ++LH P E ++ MK ++N +RG +ID +A Sbjct: 181 LGYESAASLDELLPKVDYLTLHVPGGAETKSMVGARELGLMKKTARVLNVARGGIIDEKA 240 Query: 243 AIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAE 302 EAL I G+DV+ E L+ N++ T H T E Sbjct: 241 LAEALAAGTIAGAGVDVFSVEPIA-------------ADNPLAKAPNIVITPHLGASTLE 287 Query: 303 ALTSISQTTLQNLSNLEKGETCPNEL 328 A +++ Q + + N + Sbjct: 288 AQENVAVEAAQLIKDFLLSGQVANAV 313 >UniRef50_C4ZHF5 Phosphoglycerate dehydrogenase, putative n=3 Tax=Clostridiales RepID=C4ZHF5_EUBR3 Length = 329 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 149/330 (45%), Gaps = 23/330 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + T+ + +Q + ++ D A+ + + Sbjct: 1 MKFVM--TQAVCPEGMQLL--DGIADVYVADNQDPNNYLDEMRDAAALIVRI-AKCDANA 55 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +K I G+++VD+ A ELG+ VV P + +VAEHA+ M+ L++ + Sbjct: 56 IENSPK--LKVIGRTGVGYDSVDVKKATELGIPVVITPGANNRSVAEHAVAMIFALSKNL 113 Query: 121 HRAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 A N+ F + KT G++G G IG +I KG GMR+ A+DP+ + Sbjct: 114 IEAQNEMCKGNWEIRGAKKAFELERKTVGILGLGAIGRETAKICKGCGMRIAAYDPFMTK 173 Query: 180 AALE-LGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 +E G +Y D L +SDV+S+H PLT + +++++ MK +I+N SRG + Sbjct: 174 EQVEGYGAKYYEDYVELLKDSDVVSIHVPLTDQTRNMISKKELSVMKPTALIINCSRGGI 233 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 I+ +EAL N I G DV+ +E L C N++ + H A Sbjct: 234 INEADLVEALNNGVIAGAGTDVFCSEPPKT-------------DDPLLNCRNLIVSPHSA 280 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNE 327 T EA+ ++Q ++ + +G+ P Sbjct: 281 AQTREAVIKMAQMCIKGCLAVVEGKKWPYV 310 >UniRef50_A5W066 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Pseudomonas RepID=A5W066_PSEP1 Length = 324 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 88/327 (26%), Positives = 165/327 (50%), Gaps = 16/327 (4%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 +Y T + L ++++ L + + + + N +AV + S ++ Sbjct: 3 LIYVTSPIHETILSRLSDLGEVRLGYGPNAVAYEEIR--NQVDAVFLRGG-HISAEMIAA 59 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K ++ +A AG++NVD AA + G+ V P + +V EH ++++L R++ A Sbjct: 60 SPK--LRIVARHGAGYDNVDYKAAADHGVWVTNTPGANQRSVIEHVFALLLSLCRKLPLA 117 Query: 124 YQRTRDANF--SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA 181 ++TR+ + LTG + G+T G++G G IG ++ + + FGM+++ DP ++ Sbjct: 118 SEQTRNRVWAEDRLSLTGIELEGRTLGLVGFGNIGSSVAPVAEAFGMKVIFTDPAIDPSS 177 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +VD TL S +DV+SLH PL +L+ F +MK+G M++NTSRG ++D Q Sbjct: 178 DS---RWVDFDTLLSTADVVSLHVPLLETTRNLIGVPEFAKMKDGAMLINTSRGGVVDEQ 234 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A ++ALK+ K+ G DV E + +D ++ N++ T H A T Sbjct: 235 ALVDALKSGKLAGAGADVLAAENIDMIKPFDHDTPD------IANTPNLIVTAHVAGQTD 288 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 E+L + + L+ ++ + KG+ + + Sbjct: 289 ESLLRVGMSALEAIAAVLKGQAPAHPV 315 >UniRef50_B0PHF7 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PHF7_9FIRM Length = 319 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 99/332 (29%), Positives = 158/332 (47%), Gaps = 26/332 (7%) Query: 5 VYSTKQYDKKYLQQ---VNESFGFELEFFDFLLT----EKTAKTANGCEAVCIFVNDDGS 57 + T + + Q+ + ES G ++ D L E+ A A + I D + Sbjct: 4 ILITASHFRTLCQKAIHLLESNGHQVILNDHELPYYSFEELAVWAPEIDGAII-GMDQWN 62 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V + K +K +A G +N+DL+AAK G++VV + AVAE A+ M++ Sbjct: 63 EQVFQIAPK--LKILARFGVGVDNIDLEAAKRHGVQVVNAAGMNANAVAELAVAMILNCL 120 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R I ++ D +S G + GKT G++G G IG + + L GF +RLLA+DPYP Sbjct: 121 RGIPELNRKLTDGQWSRA--VGRDLLGKTVGLLGFGDIGGRVAKKLSGFEVRLLAYDPYP 178 Query: 178 S-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 + A LGV DL T+ ++SD++S+H P P H++N F +MK +NT+RGA Sbjct: 179 NREKAAALGVTLTDLDTVLTQSDILSIHMPSIPATRHVMNRETFAKMKPDSYFINTARGA 238 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 L+D+QA ++A+ + +DVYE E + + + H Sbjct: 239 LVDTQALVDAVAGGHLAGAAVDVYEQEPL-------------PMGAPILHTPGIQCIPHA 285 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E ++IS T Q + + G+ N L Sbjct: 286 GAETRETYSNISMMTAQAVIDSLSGKEPKNWL 317 >UniRef50_Q8ZXX8 D-3-phosphoglycerate dehydrogenase (SerA) n=1 Tax=Pyrobaculum aerophilum RepID=Q8ZXX8_PYRAE Length = 323 Score = 343 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 87/338 (25%), Positives = 153/338 (45%), Gaps = 25/338 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFF-------DFLLTEKTAKTANGCEAVCIFVN 53 M S + + + +++ E E+ + E A CEA+ IF+ Sbjct: 1 MPCIFVSREGFPESMYKKLEEVGRVEVYRHGGSPWSTRGVPKEVLIDAARRCEALVIFIG 60 Query: 54 DDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMM 113 D + VL+ +K +K ++ G +++D++ AK G+ V P +AVA+ A+G++ Sbjct: 61 DVIDKEVLDAGEK--LKIVSTASVGVDHIDVEYAKRKGVVVAHTPYVLVDAVADLAVGLL 118 Query: 114 MTLNRRIHRAYQRTRDA--NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLL 171 + + R+I + R + L G + GK AG++G G IGVA+ R LK F + + Sbjct: 119 IAVTRKIALGDRLIRSGAADAVWGSLMGVNLRGKRAGIVGLGNIGVAIARRLKAFDIEVA 178 Query: 172 AFDPYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + LG+EY++L +L S SD I L LTPE N F ++K G + Sbjct: 179 YWSRRRKPEVEFALGIEYMELDSLLSSSDFIFLTMALTPETRWFFNRERFAKVKRGAYFI 238 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 N +RG L+D+ A IEAL+ + +DV++ E +L++ NV Sbjct: 239 NVARGGLVDTDALIEALEAGVLAGAALDVFDVEPL-------------PARHKLASMDNV 285 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + T H T E +++ +N+ + + + Sbjct: 286 VLTPHIGSATVETRRRMAELAAENVVSFFRTGRPIYAV 323 >UniRef50_C3XIZ9 D-3-phosphoglycerate dehydrogenase n=4 Tax=Campylobacterales RepID=C3XIZ9_9HELI Length = 535 Score = 343 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 80/333 (24%), Positives = 146/333 (43%), Gaps = 20/333 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + + L+ ++ +E L ++ + + + + + + Sbjct: 1 MKKHIIVCDHIHDEGLKILSTQDDISMENLAHLPKDELLTHLHKADVLITRSSTGVNEKL 60 Query: 61 LEELKKHG--VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 LE K +K I G +NVD+DA G+ V+ VP + A E + +++ R Sbjct: 61 LESAYKDSKKLKAIVRAGVGVDNVDIDACSYRGVVVMNVPTANTIAAVELTMTHLLSAIR 120 Query: 119 RIHRAYQRTR-DANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R A+ + + + + E G + K GVIG G IG + K F M+++A+DPY Sbjct: 121 RFPSAHTQLKVERKWKREDWYGIELKDKKLGVIGFGNIGSRVGIRAKAFDMQVIAYDPYI 180 Query: 178 SA-AALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 + AL+LG+EY + + D+I++H P + +++ +MK+GV+++N +RG Sbjct: 181 NPNKALDLGIEYTTNFDDILA-CDIITIHTPKNKQTTNMITSKEIAKMKDGVILINCARG 239 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L + E LK++KI G+DV+++E +L N+ T H Sbjct: 240 GLYNENDLYEGLKSKKIAWAGLDVFDSEPAT--------------NNKLLDLDNIYVTPH 285 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T E+ I+ + +G PN L Sbjct: 286 IGANTLESQEKIAIEAAHAAISAARGSAFPNAL 318 >UniRef50_C8QAG5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Pantoea sp. At-9b RepID=C8QAG5_9ENTR Length = 317 Score = 343 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 91/332 (27%), Positives = 152/332 (45%), Gaps = 25/332 (7%) Query: 1 MKLAVYST--KQYDKKYLQQVNESFGFELEFFDFLLT-EKTAKTANGCEAVCIFVNDDGS 57 MK+ S +YD + + + GFEL A+ + D + Sbjct: 1 MKVICTSPSFAKYDATPITTLQQQ-GFELITLPADAPLSALEPHLADTVAMIV-AFTDVN 58 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 +L + + +K + G +N++LDA + G+ V VP + AVA+ A +++ Sbjct: 59 EELLSKAPQ--LKIVCKHGVGVDNINLDATRARGIYVTNVPDANKHAVADFAFALILNSA 116 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R++ +A TR ++ + +YGKT G++G G IG + KGF MR++AFD YP Sbjct: 117 RQLTQAAVETRAGHWPR--IFATDVYGKTLGIVGLGNIGKQVALRAKGFNMRVIAFDFYP 174 Query: 178 SAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A E G+E+V + L + SD I+LH PLT E +L + A ++MK ++N SRG Sbjct: 175 DEKFAAEHGIEFVSMDQLTAASDFITLHTPLTNETRNLFDAARIKRMKKSAFLINVSRGG 234 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +++ Q +AL++ I DV+E E L N + T H Sbjct: 235 VVNEQDLFQALQDNVIAGAAADVFEQEPL--------------AEHPLFTLGNFIPTSHI 280 Query: 297 AFLTAEALTSISQTTLQNLSNLE-KGETCPNE 327 A T A+++I + + + +GE N Sbjct: 281 AGYTDGAISAIGERCVTQIVQCIQQGERPVNV 312 >UniRef50_Q6MN05 Phosphoglycerate dehydrogenase n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MN05_BDEBA Length = 328 Score = 343 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 79/320 (24%), Positives = 151/320 (47%), Gaps = 17/320 (5%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK + T ++ + + + FE+ D + A+ I + Sbjct: 1 MKKKILITDRFAQDSFLYLQQHSQFEVVRSDNPQHLPLEHLVS-AHALIIRSRTKIDEEL 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L++ ++ ++ I +GF+++DL+A ++ G+ V+ P + E+ A+ G++++ I Sbjct: 60 LKKARQ--LQLIVTCTSGFDHIDLEATQKWGVTVMHTPTANIESAAQLTWGLVLSCVNNI 117 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 A++ + ++ + +TG + G+ G++G G+IG + + + FGM ++A+DPY Sbjct: 118 QAAHKMVKAGEWNRDQITGIELAGRNYGIVGLGRIGSRVAELAQAFGMNVVAYDPYQEDE 177 Query: 181 ALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 E L + + + +DVIS H P T E H+LN + FE + G++++NTSRG++I+ Sbjct: 178 VFERLHIPRLSYEEVLKTADVISFHVPKTLETEHMLNRSQFEYIHRGIVLINTSRGSVIN 237 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 EAL+ + S+G+DVYE E + L N++ T H Sbjct: 238 ENDLCEALEKGWLRSVGLDVYEKEPL-------------NRNSNLLKYPNLVLTPHIGAN 284 Query: 300 TAEALTSISQTTLQNLSNLE 319 T +A SQ L Sbjct: 285 TEDAFFKASQIAANKLMAFF 304 >UniRef50_C9NGL5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=7 Tax=Streptomyces RepID=C9NGL5_9ACTO Length = 334 Score = 343 bits (881), Expect = 5e-93, Method: Composition-based stats. Identities = 141/329 (42%), Positives = 195/329 (59%), Gaps = 1/329 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ + + +K +++ ++ D LTE TA A G E V VN D V Sbjct: 1 MEILAFGVQSDEKPLIEKAFAGL-HDVRCLDVFLTEDTAPIAAGYEIVSTSVNADLGSRV 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L G + IA R GFNN+DLD A+ L L+V RV Y P +VAE A + M +NRRI Sbjct: 60 LQTLAAGGTQMIAQRSTGFNNIDLDVAERLALRVARVSYYSPYSVAEFAWTLAMAVNRRI 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 RA RTRD +F L+GL G M+G+TAGV+GTGKIG A RI GFGM LL +D + A Sbjct: 120 VRAVSRTRDFDFRLDGLLGRDMHGRTAGVLGTGKIGEAFARIAHGFGMNLLGWDVAENPA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LG+ YVD L +E+D+ISLH PL P HL++E A MK+ ++VN+SRG L+D+ Sbjct: 180 CTALGMTYVDKEQLLAEADLISLHVPLLPATQHLIDERALSAMKDDAILVNSSRGGLVDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A + L+ + +G+DVYE E LF+ DKS + I DD RL NV+ T HQA+ T Sbjct: 240 RALVGELRAGRFTGVGLDVYEAEAGLFYVDKSVEGIDDDTLARLVTFPNVIVTSHQAYYT 299 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNELV 329 +A+ I T++N+++ G N LV Sbjct: 300 RDAVGQIIDATVRNVTDYLAGRRSDNVLV 328 >UniRef50_O33116 D-3-phosphoglycerate dehydrogenase n=22 Tax=Actinomycetales RepID=SERA_MYCLE Length = 528 Score = 343 bits (880), Expect = 8e-93, Method: Composition-based stats. Identities = 88/327 (26%), Positives = 150/327 (45%), Gaps = 19/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 V + + + + + E+ + D K +A+ + VL Sbjct: 4 PVVLIADKLAQSTVAALGDQ--VEVRWVDGPDRTKLLAAVPEADALLVRSATTVDAEVLA 61 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K +A G +NVD+DAA G+ VV P + + AEHA+ +++ +R+I Sbjct: 62 AAPK--LKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIAE 119 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A R + +G ++GKT GV+G G+IG + + FG ++A+DPY + A A Sbjct: 120 ADASLRAHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARA 179 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +LG+E + L + +D IS+H P TPE L+++ A + K GV+IVN +RG L+D Sbjct: 180 AQLGIELMSFDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEV 239 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A+++ + + G+DV+ E L V+ T H TA Sbjct: 240 ALADAVRSGHVRAAGLDVFATEPCT--------------DSPLFELSQVVVTPHLGASTA 285 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ GE P+ + Sbjct: 286 EAQDRAGTDVAESVRLALAGEFVPDAV 312 >UniRef50_Q6F7L0 Glycerate dehydrogenase n=3 Tax=Proteobacteria RepID=Q6F7L0_ACIAD Length = 318 Score = 343 bits (880), Expect = 8e-93, Method: Composition-based stats. Identities = 77/334 (23%), Positives = 134/334 (40%), Gaps = 25/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M A D L ++ +L+ + ++ + V I + Sbjct: 1 MNAAFLDYGSLDMNDLDFSPLQACFNDLQLYSASTPDQVIPRLKDVQ-VAITNKVVINAE 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 L L K +K I + G NNVDL AAK G+ V Y +VA+H + +M+ L Sbjct: 60 ALTRLPK--LKLILVSATGTNNVDLRAAKAQGIVVCNCQGYGTASVAQHTLTLMLALATS 117 Query: 120 IHRAYQRTRDANFSLE------GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + R + + GKT G++G G++G + R+ + FGM++L Sbjct: 118 LLRYDHAVAQGRWQQASQFCFLDYPIIELSGKTLGIVGYGELGKEVARLAQAFGMKILIA 177 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 + + ++L L + D +SLHCPLT HL++ AF MK ++N + Sbjct: 178 NLPQRPKHED----RLELEALLPQVDFLSLHCPLTEHTQHLIDAHAFALMKPSAFLINCA 233 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG ++ QA ++ALK +I DV E ++ N++ T Sbjct: 234 RGGIVHEQALLDALKQGRIAGAATDVLSIEPPKNGNPLLDE-----------KLPNLIIT 282 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNE 327 H A+ + ++ + + +N G+T Sbjct: 283 PHSAWGSVQSRQRMVEQLAENAKAFSIGQTIRQV 316 >UniRef50_A1AQ02 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=10 Tax=Bacteria RepID=A1AQ02_PELPD Length = 318 Score = 342 bits (879), Expect = 9e-93, Method: Composition-based stats. Identities = 89/322 (27%), Positives = 134/322 (41%), Gaps = 21/322 (6%) Query: 4 AVYSTKQYDKKYLQQVNESFGFE-LEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 + + D + +D E+ G + + I R ++ Sbjct: 5 VFLNAARLDFDGKLDFSPLSDLTAFTRYDNSSDEEIPSRVEG-QTIVITKELPLGRELIH 63 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 VK I G+NN+D+ AA+ G+ V VP+Y +AVA+ AI M+ L+ + + Sbjct: 64 CFPA-SVKLICEAGTGYNNIDIAAARSRGIGVCNVPSYSTDAVAQLAITFMLNLSASLVQ 122 Query: 123 AYQRTRDAN---FSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 R N F L F + GKT GVIG G+IG ++ I + GM+++ P Sbjct: 123 QQTMLRRGNLDNFQKSLQLPHFELNGKTLGVIGFGEIGRRVIAIARTLGMKIIVHSRTPR 182 Query: 179 AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALI 238 L+ + +V L L + SD +SLHCPL H++N E MK I+NTSRG LI Sbjct: 183 PE-LDPDLRFVSLEELLATSDFVSLHCPLNDATRHVINAERLEMMKPTAFIINTSRGPLI 241 Query: 239 DSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAF 298 A +AL I G+DV E E + L + NV+ T H + Sbjct: 242 HEPALSQALTRGTIAGAGLDVQEQEPP-------------EPGDPLYSLENVILTPHIGW 288 Query: 299 LTAEALTSISQTTLQNLSNLEK 320 E + T N+ K Sbjct: 289 KRLETRQRLIGLTAANIDAFIK 310 >UniRef50_Q7D366 Putative phosphoglycerate dehydrogenase n=1 Tax=Agrobacterium tumefaciens str. C58 RepID=Q7D366_AGRT5 Length = 317 Score = 342 bits (879), Expect = 1e-92, Method: Composition-based stats. Identities = 89/335 (26%), Positives = 153/335 (45%), Gaps = 25/335 (7%) Query: 1 MKLAVYSTKQYDKKYL---QQVNESFGFELE---FFDFLLTEKTAKTANGCEAVCIFVND 54 M V T +Y + + + G ++ F + ++ + +AV V D Sbjct: 1 MSKTVLVTATNYSRYCADAKAMLAAEGIDVVENGFGRPMTFDELSARLGDVDAVIAGV-D 59 Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 + V + +K IA G +N+D+DAA G+ V P + AVAE +G+++ Sbjct: 60 TWNERVFNLAPR--LKAIARFGVGVDNIDIDAAHRHGIAVTNAPGGNANAVAELTLGLIL 117 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 + RRI + R + G + G+ G++G G I + R L GF + ++A+D Sbjct: 118 SAMRRIPYLHDALRGGAWDR--FVGQELIGRRVGLLGFGNIARKIARKLCGFDVEVIAYD 175 Query: 175 PYPSA-AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 +P AA +LGV ++ + S SD++ + P PE L++ F +MK G + +NT+ Sbjct: 176 KFPDQVAATKLGVRMCEMDEVLSSSDILVMMMPSLPETRRLMDAGRFARMKPGSIFINTA 235 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RGAL+D +A +AL + + + +DVYE E L L ++ T Sbjct: 236 RGALVDEKALYDALVSGHLQAAAIDVYETEPAL-------------PDNPLFTLPQIVTT 282 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H A T E TSI + T + + ++ N+L Sbjct: 283 PHTAAETYETYTSIGRITAEAVIDVLANRQPRNQL 317 >UniRef50_B2GCQ6 D-2-hydroxyisocaproate dehydrogenase n=3 Tax=Lactobacillus fermentum RepID=B2GCQ6_LACF3 Length = 327 Score = 342 bits (879), Expect = 1e-92, Method: Composition-based stats. Identities = 105/328 (32%), Positives = 168/328 (51%), Gaps = 2/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ +YS ++ Y++ G +++ + L ++TAK A G + + +D V Sbjct: 1 MKILMYSILDTERPYVEAWVNKTGHQVKMVEEGLNKETAKWAAGFDGIDFQQTNDLDPEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ G+K + R GF+ +DL A + L V VPAY P A+AE + + L R++ Sbjct: 61 YATLEGLGIKQLTARMVGFDMIDLKQAADHHLLVTNVPAYSPRAIAEMGLTQALRLVRKL 120 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 QR + +F GL +Y T GVIG G IG A R+ G +LA DP A Sbjct: 121 GYYDQRMDNYDFRWVGLESTEIYNLTVGVIGAGHIGGATARLYSALGANVLATDP-VHHA 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 LE + YVDL TL E+D++++H PL E +LL+ AF +MK+ ++N +RG L+D+ Sbjct: 180 ELEADLTYVDLETLLREADIVTIHTPLNEETANLLDRTAFAKMKDSAYLINMARGGLVDT 239 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A IEAL+N ++ +D +E F S + + + L A NVL + H AF T Sbjct: 240 AALIEALQNHQLAGAALDTLADETGYFERQASREEVSESYLT-LRAMPNVLISPHSAFFT 298 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ +I + L ++ + G+ + Sbjct: 299 DTAIKNIVEMGLDDVVRIVNGKRPLYPV 326 >UniRef50_B0K1J9 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=16 Tax=Bacteria RepID=B0K1J9_THEPX Length = 320 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 93/333 (27%), Positives = 161/333 (48%), Gaps = 26/333 (7%) Query: 1 MKLAVYST-KQYDKKYLQ--QVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVND 54 M+ + T + + K ++ + + +E+ + + + + + + D Sbjct: 1 MRKKILITPRSFGKSSNLPFEMLKKYDYEIIKNESGQPYEESQLIDLIKDVDGIIVGL-D 59 Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 + VL KK +K I G +N+D+D A+ +G+K+ P + E+VA+ +M+ Sbjct: 60 KITSNVLRNAKK--LKVITKYGVGVDNIDVDEAERMGIKITYTPDANKESVADLVFALML 117 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 L+R I + R+ + + G +Y KT G+IGTG IG + + GF M++LA+D Sbjct: 118 GLSREIIKLDNIVRNNRWEK--IIGNEIYKKTIGIIGTGAIGRCVAKRATGFDMKILAYD 175 Query: 175 PYPS-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 YP+ A +G++YVD L ESD I+LH PLT E YH ++E + MK+ I+NTS Sbjct: 176 KYPNYEFANSIGMKYVDKKALLEESDFITLHLPLTEETYHFIDEEELKIMKDTAYIINTS 235 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RG +I+ A ALKN+KI +DV+E E + +L N++ T Sbjct: 236 RGGIINENALYNALKNKKIAGAALDVFEIEPPI--------------DSKLLKLDNIILT 281 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 H T +A + ++ L ++ +G Sbjct: 282 PHCGASTKDATDRMGIMAVEGLISVLEGMEPKY 314 >UniRef50_P0A545 D-3-phosphoglycerate dehydrogenase n=57 Tax=Actinomycetales RepID=SERA_MYCBO Length = 528 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 90/327 (27%), Positives = 151/327 (46%), Gaps = 19/327 (5%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 V + + + + E+ + D +K +A+ + VL Sbjct: 4 PVVLIADKLAPSTVAALGDQ--VEVRWVDGPDRDKLLAAVPEADALLVRSATTVDAEVLA 61 Query: 63 ELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHR 122 K +K +A G +NVD+DAA G+ VV P + + AEHA+ +++ +R+I Sbjct: 62 AAPK--LKIVARAGVGLDNVDVDAATARGVLVVNAPTSNIHSAAEHALALLLAASRQIPA 119 Query: 123 AYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA-A 181 A R+ + +G ++GKT GV+G G+IG + + + FG ++A+DPY S A A Sbjct: 120 ADASLREHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARA 179 Query: 182 LELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 +LG+E + L L + +D IS+H P TPE L+++ A + K GV+IVN +RG L+D Sbjct: 180 AQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEA 239 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +A+ + + G+DV+ E L V+ T H TA Sbjct: 240 ALADAITGGHVRAAGLDVFATEPCT--------------DSPLFELAQVVVTPHLGASTA 285 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA +++ GE P+ + Sbjct: 286 EAQDRAGTDVAESVRLALAGEFVPDAV 312 >UniRef50_B6YUM0 D-isomer specific 2-hydroxyacid dehydrogenase n=9 Tax=Thermococcaceae RepID=B6YUM0_THEON Length = 333 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 91/332 (27%), Positives = 154/332 (46%), Gaps = 27/332 (8%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M+ V + K L+++ + EL + + E+ + + + + + R V Sbjct: 1 MRPKVLVLFKIKSKPLEELKKHADVELLLYPSV--EELKEKIGEFDGIIVSPLNPIPREV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E +K +K I+ AG+++VD+ AA E G+ V +V EAVAE A+G+M+ L RRI Sbjct: 59 IERAEK--LKVISCHSAGYDHVDVKAATERGIYVTKVSGVLSEAVAEFAVGLMIALLRRI 116 Query: 121 HRAYQRTRDANFS-----LEGLTGFT-MYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 + R + G +YGKT G++G G IG A+ R +K G ++ + Sbjct: 117 VYTDRFIRAGKWESHRVIWSGFKDIETVYGKTVGILGMGAIGKAIARRVKALGTEVVYWS 176 Query: 175 PYPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 E+ +Y+ L + +D++ L P TPE YH++NE + M G +VN Sbjct: 177 RSRKKDIEEEVNAKYLSLEEVLKSADIVVLALPATPETYHIINEERLKLM-EGKYLVNIG 235 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACH-NVLF 292 RG+L+D +A ++ALK K+ DV+E E L + Sbjct: 236 RGSLVDEEALVKALKEGKLKGYATDVFEREPVT--------------EHELFGMEWETVL 281 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGETC 324 T H A L+ EA+ + ++NL + +GE Sbjct: 282 TPHYAGLSREAMEDMGFRAVENLLTVLRGEVP 313 >UniRef50_C6PA05 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Thermoanaerobacterales RepID=C6PA05_CLOTS Length = 355 Score = 341 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 96/332 (28%), Positives = 166/332 (50%), Gaps = 26/332 (7%) Query: 1 MKLAVY--STKQYDKKYLQQVNESFGFELEFFDFLLT---EKTAKTANGCEAVCIFVNDD 55 MK+ + S + + + + + +E+ + ++ + + V + + D Sbjct: 38 MKVLITPRSFGKTSNIPFE-MLKKYDYEIIRNETGKPYEEDELKELIKDVDGVIVGL-DK 95 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 + VL+ KK +K I G +N+D++ A++LG+KV P + E+VA+ A MM+ Sbjct: 96 ITEDVLKNAKK--LKVITKYGVGLDNIDINYAEKLGIKVTYTPGANKESVADLAFTMMLG 153 Query: 116 LNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 L+R I + + R+ ++ + G +YGKT G+IGTG IG + + GF M +LA+D Sbjct: 154 LSRDIIKLDKIVRNNQWNK--IIGCEIYGKTIGIIGTGSIGKCVAKRATGFDMEILAYDK 211 Query: 176 YPS-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 YP A ++G++YVD TL +SD I+LH PLT E YH ++E MK+ I+NTSR Sbjct: 212 YPDYDFADKIGMKYVDKKTLLEKSDFITLHVPLTDEMYHFIDEEELNMMKDTAYIINTSR 271 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +I+ A ALK++KI +D +E E L +L N++ + Sbjct: 272 GGIINENALYSALKSKKIAGAALDAFETEPPL--------------NNKLLELDNIILSP 317 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPN 326 H T +A + ++ L ++ +G Sbjct: 318 HCGASTKDATDRMGIMAVEGLISVLEGMEPKY 349 >UniRef50_B8FRV3 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=2 Tax=Desulfitobacterium hafniense RepID=B8FRV3_DESHD Length = 320 Score = 341 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 137/314 (43%), Gaps = 23/314 (7%) Query: 19 VNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALR 75 + E G L E + +N LE +K I Sbjct: 23 ILEKKGCRLVMIPPNGLREREDFKAVLAEAHVWVVGIN-KVYAEDLEAAP--NLKLIIKH 79 Query: 76 CAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLE 135 G +++DL AA G+ V P + +VA+ A G M++L R+I A +RTRD + Sbjct: 80 GTGVDSIDLKAAAARGITVANAPGTNANSVADLAFGFMLSLARQIVSADKRTRDGFW--G 137 Query: 136 GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD-PYPSAAALELGVEYVDLPTL 194 + G +YGKT GV+G G+IG ++R GF M +L +D + S E V L + Sbjct: 138 TVMGKDVYGKTLGVLGLGQIGKGVIRRASGFDMNILGYDLVHHSQFEKEYRVRAATLEEI 197 Query: 195 FSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGS 254 SE+D IS+H PL ++++ + E+M+ ++NTSRG ++D A + LK ++I Sbjct: 198 MSEADYISVHLPLLESTKNIIDRSLLEKMRPTAFLINTSRGGVVDETALYDLLKEKRIAG 257 Query: 255 LGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQN 314 +DV+ E NV+ H T A+ ++S+ ++ Sbjct: 258 AALDVFATEPPRQ--------------SPFFELDNVIVAPHMGAYTEGAMGAVSEILAES 303 Query: 315 LSNLEKGETCPNEL 328 + + G+ + + Sbjct: 304 IVRVLAGKEPLSVI 317 >UniRef50_B2IKB7 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=8 Tax=Proteobacteria RepID=B2IKB7_BEII9 Length = 331 Score = 341 bits (877), Expect = 2e-92, Method: Composition-based stats. Identities = 83/328 (25%), Positives = 150/328 (45%), Gaps = 20/328 (6%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 + + + L + + G L+ D + TE A + +A+ I V++ Sbjct: 4 ILVAGRIHEAGLDILRNASGITLDLVDEVSTESYAPLVDRADAILIR-TQPLPESVIDRA 62 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 +K +K+++ G++ VD++A + + V + +VAEHA+ +M+ + +R+ Sbjct: 63 QK--LKFVSRHGVGYDVVDVEALTRRNIPLAIVGDVNSRSVAEHAMMLMLAVAKRVCVYD 120 Query: 125 QRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAA-L 182 TR + L + GKT +IG G+IG + + +GF M +LA+DP+ AA Sbjct: 121 AATRAGKWGIRNDLYATDISGKTLLLIGFGRIGRLVASMARGFDMTILAYDPFLDEAAIK 180 Query: 183 ELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 G DL +D +SLH P P N LL E+ MK G +++NT+RG ++D + Sbjct: 181 AAGAIPTRDLEGALRSADFVSLHMPP-PRNGALLGESELASMKPGAILINTARGGVVDEK 239 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A +AL + ++ G+DV+ E L V+ T H A +T Sbjct: 240 ALAKALTDGRLAGAGLDVFTQEPP-------------PADHPLLQMDRVILTPHSAVMTR 286 Query: 302 EALTSISQTTLQNLSNLEKGETCPNELV 329 E ++ + +N+ + G P+ +V Sbjct: 287 ECAARMAVSASRNILDYFAGRLDPSLVV 314 >UniRef50_D1W6S1 4-phosphoerythronate dehydrogenase n=4 Tax=Prevotella RepID=D1W6S1_9BACT Length = 329 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 82/331 (24%), Positives = 148/331 (44%), Gaps = 33/331 (9%) Query: 2 KLAVYS-----TKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDG 56 + V +++ L ++ E+ + A + V + Sbjct: 13 NIVVLDGHCANPGDLSWDGFKELGS-----LTVYERTKPEEVVERAKDAQIVLV-NKVSM 66 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 ++ +L + +KYI + GFN++D+ AA+E G+ V +P+Y +VA+ + T+ Sbjct: 67 KADIIAQLPQ--LKYIGVLATGFNHIDVKAAQEHGVTVCNIPSYSTYSVAQMVFASIFTI 124 Query: 117 NRRIHRAYQRTRDANFSLEGLTGF------TMYGKTAGVIGTGKIGVAMLRILKGFGMRL 170 R+ Q+TR+ +S + + GKT G++G G IG+ + RI + FGM + Sbjct: 125 TNRVEHYAQQTREGQWSKRSDFCYWDTPLLELAGKTMGIVGLGNIGMKVARIAREFGMEV 184 Query: 171 LAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 A+ ++ L G++ L LFS SD++SLHCPL+ L+ +MK+G +++ Sbjct: 185 YAY-TSKNSVDLPSGIQKTTLDGLFSVSDILSLHCPLSERTRELIKADNLRKMKHGAILI 243 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 NT RG L++ AL++ ++ + G DV +E L N Sbjct: 244 NTGRGPLVNEADVAAALESGQLAAYGADVMCSEPPA-------------ADNPLLKQPNA 290 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKG 321 T H A+ T EA + + L N+ +G Sbjct: 291 FITPHIAWATVEARSRLMNIALNNVRCFLEG 321 >UniRef50_B8FRA5 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=78 Tax=Firmicutes RepID=B8FRA5_DESHD Length = 337 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 74/333 (22%), Positives = 136/333 (40%), Gaps = 22/333 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGF-ELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K V +Q ++ + + + + E + + K + + I + + Sbjct: 13 KPKVLIARQVPQEVEEWIGRHCEYSKWEGSGDIPRSELLKQLGDVDGLLI-NREKIDGEL 71 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ K +K +A G+NN D+ + + P + VA+ G+M++ RR+ Sbjct: 72 LDAAPK--LKIVANISVGYNNFDIGEMQARKVLGTHTPNVLDDTVADLVFGLMLSTARRL 129 Query: 121 HRAYQRTRDANFS---LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPY 176 + + ++ L G ++ +T G+IG G+IG A+ + K GF M +L + Sbjct: 130 CELDRYVKAGRWNETVTPDLFGMDVHHQTLGIIGMGRIGRALAQRGKWGFDMNILYHNRS 189 Query: 177 PSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 A + Y L L SD + L PL+P+ +L++ F MK + ++ SRG Sbjct: 190 RHPEAEQRFDARYCTLEELLQRSDFVVLLAPLSPQTVNLMSGREFGLMKRSAVFISASRG 249 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +D +A +EAL+ +I G+DVY E L NV+ H Sbjct: 250 ETVDEEALVEALREGRILGAGLDVYRKEPI-------------PPDHPLLRFKNVVTLPH 296 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T ++++ +NL K E P + Sbjct: 297 LGSATTRTRLAMARMAAENLLIGLKREIPPQCV 329 >UniRef50_D2W085 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W085_NAEGR Length = 388 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 154/318 (48%), Positives = 215/318 (67%), Gaps = 5/318 (1%) Query: 6 YSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL- 64 S Y Y + ++ S F L+F D LTE T + A + V +FVND +R VL+ L Sbjct: 58 TSPYDYLPNYERFMSYSGPFHLKFVDARLTESTVELAEHSDFVSVFVNDCLNRNVLQTLS 117 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 K+G+K +ALR AGFNNVDL AA E G+KV RVP Y P A A+ I ++M LNR+IH+A+ Sbjct: 118 HKYGIKCVALRSAGFNNVDLSAASEFGVKVCRVPEYSPAATADFTIALIMALNRKIHKAF 177 Query: 125 QRTRDANFSLEGLTGFTMYGKTAGVIG-TGKIGVAMLRILK-GFGMRLLAFDPYPSAAAL 182 R RD++FSL+GL GF M K G++G +GKIG + + L+ GFG R++ +D Y + Sbjct: 178 NRLRDSDFSLDGLMGFNMSSKVFGIVGGSGKIGKLVAKCLRMGFGARVIVYDSYRDPELV 237 Query: 183 ELGVEYVD-LPTLFSESDVISLHCPLTPE-NYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 +G+E+VD + ++++ SDVI LHCPL HL+N + +MK+GVMI+NTSRG L + Sbjct: 238 NMGIEFVDNIDSIYAHSDVICLHCPLIKGVTEHLINSESISKMKDGVMIINTSRGGLCRT 297 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 IE LK+QKIGSLG+DVYE E+DLFFED+ ++I+DD F RL NV+ T HQAF T Sbjct: 298 DDLIEGLKSQKIGSLGIDVYEFEQDLFFEDRRFEIIKDDTFTRLLTFPNVIVTPHQAFFT 357 Query: 301 AEALTSISQTTLQNLSNL 318 EA+++I+QTTL++L + Sbjct: 358 QEAISNIAQTTLESLYSF 375 >UniRef50_C3WAJ0 D-isomer specific 2-hydroxyacid dehydrogenase n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WAJ0_FUSMR Length = 313 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 95/330 (28%), Positives = 153/330 (46%), Gaps = 31/330 (9%) Query: 1 MKLAVYSTKQYDKKYLQ-QVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V + L + + +G E+E +D E + + E V I +R Sbjct: 1 MKIVVLDGYTENPGDLSWEWLKKYG-EVEIYDRTPEELVYERSKDAE-VIITNKVPFNRE 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +E L K +KYI + AG+N +D++A KE + V P Y + VA+ ++ + Sbjct: 59 RVERLPK--LKYIGITAAGYNIIDIEAVKEKNIIVTNTPNYGSKVVAQMVFAHLLEITNN 116 Query: 120 IHRAYQRTRDANFS------LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 + + +D +S ++ GKT G++G G IG + +I FGM++L + Sbjct: 117 VGLHSKSVKDGEWSEKLDFCYWKKPIISLEGKTIGILGYGNIGKEVEKIALVFGMKILIY 176 Query: 174 DPYPSAAALELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 D L ++ V L + SDVISLH PLT E Y L+N+ ++MK V+++NT Sbjct: 177 DR------KNLNIDNQVTLEEILKRSDVISLHLPLTEETYRLVNKETIKKMKKDVILINT 230 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 SRG L+D +EA+K+ KI +G DV +NE L + Sbjct: 231 SRGPLVDETDLLEAIKSGKIYGVGFDVLKNEPPQK-------------DSELLKNDRINI 277 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 T H A+ EA +I + +NL N G+ Sbjct: 278 TPHIAWAAIEARQNIMKIAEENLKNYLNGK 307 >UniRef50_C5DTI9 ZYRO0C08932p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DTI9_ZYGRO Length = 469 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 87/323 (26%), Positives = 140/323 (43%), Gaps = 12/323 (3%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEK-TAKTANGCEAVCIFVNDDGSRP 59 MK+ + + E G+++EF L E+ + A+ I + Sbjct: 59 MKILLLENVN---ATAVSIFEDQGYQVEFHKSSLPEEELIEKIKDVHAIGIRSKTKLTAN 115 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 VL+ K + I C G N VDL A G+ V P + +VAE IG +++L R+ Sbjct: 116 VLKHAK--NLVSIGCFCIGTNQVDLKYATHAGIAVFNSPFSNSRSVAELIIGEIISLARQ 173 Query: 120 IHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSA 179 + ++ + + GKT G+IG G IG + + + GM +L +D Sbjct: 174 LGDRSIELHTGAWNKVSNRCWEVRGKTLGIIGYGHIGSQLSVLAEAMGMHVLYYDTV--- 230 Query: 180 AALELG-VEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 + LG V L L + SD I+ H P TPE ++L+ F MK G ++N SRG + Sbjct: 231 TIMALGTARQVPTLDELLNNSDFITCHVPATPETKNMLSAPQFAAMKEGAYVLNASRGTV 290 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D A I+A K KI +DVY +E +D + + L + N++ T H Sbjct: 291 VDIPALIQAFKVGKIAGAALDVYPSEPGKNGAGAFSDDL-NPWASELISLPNIILTPHIG 349 Query: 298 FLTAEALTSISQTTLQNLSNLEK 320 T EA ++I +L+ Sbjct: 350 GSTEEAQSAIGVEVAASLTKYIN 372 >UniRef50_Q1MPI0 Lactate dehydrogenase and related dehydrogenases n=2 Tax=Desulfovibrionaceae RepID=Q1MPI0_LAWIP Length = 323 Score = 340 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 101/336 (30%), Positives = 167/336 (49%), Gaps = 27/336 (8%) Query: 1 MKLAVYSTKQYDKKYLQQV--NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M++ + S K+ + E+ G +L +D E+T + A + + + D + Sbjct: 1 MQITILSGKETN-PGDNPWTPLEALG-KLTVYDLTKPEQTVERAKDADILLV-GRDILTT 57 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +EEL K +K I + G+N +D++ A + G+ V+ V AY +AVA+HA +++ L R Sbjct: 58 EHIEELPK--LKCIGVLGTGYNQIDIETAGKRGIPVINVTAYGVDAVAQHAFALLLELCR 115 Query: 119 RIHRAYQRTRDA-----NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 Q R+ +++ + K G+IG G IG I GF M +LA+ Sbjct: 116 HTAALDQAIRNGAWSSPDWAPWKYPQVELTYKCFGIIGYGNIGQKAGYIAHGFDMSVLAY 175 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 D P + DL +F +DV+SLHCPLT +N+HL+N+ E MK+G +I+N + Sbjct: 176 DERPVQPPSYTPFSFADLDEVFKNADVLSLHCPLTEDNFHLVNKKRIETMKDGAIIINVA 235 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 RGAL+D QA +AL + K+G LG D + +E ++ L + N +FT Sbjct: 236 RGALLDEQAVADALISGKLGGLGSDAFVDEPI-------------NLNNPLLSAPNTVFT 282 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H A+ + EA +I + +NL G+ P +V Sbjct: 283 PHIAWESVEARRNIVRILAENLKAWMDGK--PQSVV 316 >UniRef50_C0BYY9 Putative uncharacterized protein n=1 Tax=Clostridium hylemonae DSM 15053 RepID=C0BYY9_9CLOT Length = 330 Score = 340 bits (874), Expect = 4e-92, Method: Composition-based stats. Identities = 90/333 (27%), Positives = 156/333 (46%), Gaps = 24/333 (7%) Query: 2 KLAVYSTKQYDK-KYLQQVNESFGFELEFFDFLLT----EKTAKTANGCEAVCIFVNDDG 56 K+ + ++ ++ +++ ES G EL + L ++ A+ +A + + D+ Sbjct: 9 KILITASHYHELCADARELLESRGHELMINESALPYYTFQQLAEVVGNIDAAVVGL-DEW 67 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 + V + +K IA G +N+D D AKE G+KV+ P + AVAE +G M+ L Sbjct: 68 TEEVFRMAPR--LKVIAKFGVGTDNIDCDTAKEYGIKVINAPGQNSNAVAELTVGFMIQL 125 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R I Y+ R + G + GKT G+ G G + + + L F ++A D + Sbjct: 126 LRNILPLYEGIRQGQWVR--YIGGELKGKTVGLFGFGAVAKLVAKKLSSFETEVIACDLH 183 Query: 177 PSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P + A + V V + SD++S+H P T YHL+++A +MK G ++N +RG Sbjct: 184 PDSEYAKKYNVGLVSAEEVVERSDILSVHLPATSATYHLVDKAMISKMKRGACMINCARG 243 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 A++D++A EALK+ + +D +E E L C NV+ T H Sbjct: 244 AVVDTEALTEALKSGYLAGAALDAFETEPL-------------PADSLLLTCDNVICTPH 290 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA ++S T Q + ++ +G + Sbjct: 291 TGAETYEAYRNVSLCTAQGILDVLEGREPLYWV 323 >UniRef50_C8P020 D-lactate dehydrogenase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8P020_ERYRH Length = 331 Score = 340 bits (874), Expect = 4e-92, Method: Composition-based stats. Identities = 100/329 (30%), Positives = 168/329 (51%), Gaps = 3/329 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V++ ++ +++ + E+ + L+ G + + N + Sbjct: 3 KFIVFNVREEERELTLDWAKRNNVEVTMAEGQLSMDNIHMVEGFDGLSTSQNTKLEPEMY 62 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 LK +G+K IA R AGF+ DLD A E GL + VP+Y PE++AE ++ ++L R++ Sbjct: 63 SILKGYGIKQIAQRSAGFDYYDLDLATENGLIITNVPSYSPESIAEFSVTSALSLIRKLR 122 Query: 122 RAYQRTRDANFSLE-GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 ++TR +F + + + T GV+GTG IG + FG ++LAFD Y + Sbjct: 123 VIEEKTRQHDFRWQPQIRAGLLKEMTVGVVGTGHIGRKSAELFSAFGAKVLAFDVYQNEE 182 Query: 181 ALELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A + V YVD + L S SDV+SLH P T +N+H N F + K +N +RG+++D Sbjct: 183 AKQY-VTYVDSVEELVSMSDVVSLHVPATKDNHHQFNAEMFRKFKPNAYFINAARGSVVD 241 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 ++A IEAL + +D YENE +D SN I+D++F + +LFT H A Sbjct: 242 TKALIEALNQGHLAGAALDTYENESPFIPKDFSNQTIEDELFLEVLNHEKILFTPHIAHY 301 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNEL 328 T ++ +I + L ++ + + T N + Sbjct: 302 TDVSVRNIMEFALTSVLEILETGTTANRV 330 >UniRef50_A0LN07 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Bacteria RepID=A0LN07_SYNFM Length = 317 Score = 340 bits (873), Expect = 5e-92, Method: Composition-based stats. Identities = 87/331 (26%), Positives = 146/331 (44%), Gaps = 23/331 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K + + + + + E EL + L + A + + I N +R ++ Sbjct: 4 KFKILLYESMHARGTEVLAEKC--ELVYATSLDEKNLIAQAADVDGIIIRANGAVTRALI 61 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 E + +K I G + +DL AKE G+KVV P + E+VAEH +GM + L + I Sbjct: 62 ESAPR--LKVIGRHGVGLDAIDLRCAKERGVKVVFTPTANTESVAEHFVGMAIMLAKMIR 119 Query: 122 RAYQRTRDANFS-LEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDP--YP 177 R +++ L G ++GK GV+G G+IG RI + GF M ++ +D YP Sbjct: 120 TGDIALRTGDWAARNRLIGTELHGKALGVLGFGRIGRQTARICRNGFAMNVIYYDVCDYP 179 Query: 178 SAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A EL + V +F +SD IS++ PL P H +N MK ++N +RG + Sbjct: 180 -AVEKELQAKRVSGEEVFEQSDFISVNLPLLPSTRHFVNAKLIRLMKPTAFLINMARGPV 238 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 + + AL+ ++I +G DVYE E L N + T H + Sbjct: 239 WNEEDVAGALREKRIAGVGSDVYEVEPV-------------PADHPLLKMDNFVGTPHMS 285 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + EA+ +S ++ + +G + Sbjct: 286 AHSEEAMIRMS-LVASDVVAVLEGREPEYPV 315 >UniRef50_C5PUM3 Glyoxylate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C5PUM3_9SPHI Length = 329 Score = 340 bits (873), Expect = 5e-92, Method: Composition-based stats. Identities = 83/338 (24%), Positives = 143/338 (42%), Gaps = 26/338 (7%) Query: 1 MK--LAVYSTKQYDKKYLQQVNESFGFELEFF---DFLLTEKTAKTANGCEAVCIFVNDD 55 MK + VY ++ ++ L + E G L E+ + + Sbjct: 1 MKDIMKVYISRNVPQEGLNYLTE-HGLTYTVNMENKKLTQEEVIIECQSADLLLNVGGVP 59 Query: 56 GSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMT 115 + + +K IAL G+++VD+DAA + G+ V P A A+ A +M+ Sbjct: 60 LDQHFFDNCAH--LKGIALASVGYDHVDMDAASKAGIPVSNTPDVLSGATADVAFLLMLA 117 Query: 116 LNRRIHRAYQRTRDANFSLEGL---TGFTMYGKTAGVIGTGKIGVAMLRILKG-FGMRLL 171 ++R+ R+ ++ G + GKT G+ G G+IG+ + R + +GM+++ Sbjct: 118 VSRKAFYRANEIREGKWNDFEFTKDLGIELNGKTLGIYGLGRIGLELARKAQAAYGMKVI 177 Query: 172 AFDPYPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIV 230 + +P+ A L EYV+ L + SDV+S+H L+PE + N+ F +MKN +++ Sbjct: 178 YHNRHPNETAKRVLNAEYVNFDELLTRSDVLSVHANLSPETQYRFNKETFARMKNSAILI 237 Query: 231 NTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNV 290 NT RG ++ Q AL N I G+DV + E L +V Sbjct: 238 NTGRGKIVHEQDLYTALVNGDIWGAGLDVTDPEPMK-------------ADSPLLTLPSV 284 Query: 291 LFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E T++ + NL K P + Sbjct: 285 CVLPHIGSATIETRTNMIKMAANNLIAASKSNHMPQIV 322 >UniRef50_UPI0001B4E409 glyoxylate reductase n=2 Tax=Streptomyces RepID=UPI0001B4E409 Length = 333 Score = 339 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 90/333 (27%), Positives = 140/333 (42%), Gaps = 18/333 (5%) Query: 1 MKLAVYSTKQ-YDKKYLQQVNESFG-FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSR 58 M V +T+ L ++ + + A G + ND Sbjct: 1 MTQRVLTTRPDLPGGGLDRLAAQSELVRWDGDGKPEPAELHALAAGASGILCLGNDRVDA 60 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 +L+ +K + L GF+ VD +AA E G+ V P E A+ +++ R Sbjct: 61 ALLDAAG-PSLKVVGLASMGFDGVDREAAAERGVVVTHTPGVLAETTADLTFSLILMARR 119 Query: 119 RIHRAYQRTRDANFSL---EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R+ A + L + G ++G T G++G G+IG A+ R +GFGMR+L DP Sbjct: 120 RLGAARDSLAAGRWDLFRMDDYLGLDIHGATLGLVGFGQIGRAVARRAQGFGMRVLHHDP 179 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 + + + VDLPTL +E+DV+SLH PLTP HL+ A MK+ +V+TSRG Sbjct: 180 FAPDDTQDPPSKAVDLPTLLAEADVVSLHVPLTPGTRHLIGAAELAAMKSTATLVSTSRG 239 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 +ID A + A++ I S G+DVYE E L V H Sbjct: 240 GVIDENALLHAVREGGIHSAGLDVYEREPMGTD------------LSPLVGEPRVATLPH 287 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T ++ + N+ + +G L Sbjct: 288 IGSATEATRAAMVDLAVDNILEVLEGRPATTPL 320 >UniRef50_B0PA81 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PA81_9FIRM Length = 316 Score = 339 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 93/335 (27%), Positives = 160/335 (47%), Gaps = 25/335 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V L + F+++++D E+T + EAV + V Sbjct: 1 MKVVVLD-GFLAGYGLNGLPLPDTFKIKWYDNTPPEQTIERIGTAEAVFV-NRLRLDARV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E +++ G+N +DLDAA+ G+ V VPAY AVA++ I +++ + Sbjct: 59 FEACP--SLRFAGTFGTGYNMIDLDAARRAGVTVCNVPAYSTAAVAQNTISLLLNIATMT 116 Query: 121 HRAYQRTRDANFS------LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 H + +++ L + F + GKT G+IG G IG A+ RI FGMR+LA+ Sbjct: 117 HIHSRYVSTGHWTDPTDHALVSVPMFELAGKTIGLIGCGDIGSAVGRIAAAFGMRVLAYR 176 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 +P +A + +V L L+++SD++SLHCPLTP+ +++ AA +MK+G +++NT+R Sbjct: 177 RHPDPSAGAY-IRFVALDALYAQSDIVSLHCPLTPQTRGMIDRAAIGRMKDGAVLLNTAR 235 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G L+ + +AL K+ G+DV +E L+ V+ T Sbjct: 236 GGLLCERDVADALDCGKLYMAGLDVLCDEPPA-------------PDSPLARHPRVICTP 282 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H +++ E + + NL +G N +V Sbjct: 283 HISWMPRETRARLLRAAADNLLCFLEGN-PQNVIV 316 >UniRef50_Q4WHR3 D-3-phosphoglycerate dehydrogenase n=3 Tax=Eurotiomycetidae RepID=Q4WHR3_ASPFU Length = 635 Score = 339 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 84/379 (22%), Positives = 144/379 (37%), Gaps = 67/379 (17%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLE 62 V ++ L + S E++ L ++ + EA+ + + +L Sbjct: 9 PKVLVPEKLSPDGLALLRAS--LEVDERRGLDADELLQIIPEYEALVVRSETKVTANLLR 66 Query: 63 ELKKHGVKYIALRCAGFNNV------------------------DLDAAKELGLKVVRVP 98 K+ +K +A G +NV D++ A +LG+ VV P Sbjct: 67 AAKQ--LKVVARAGVGVDNVGELAQPPLPPSPSLGSWPLTSHRTDVEEATKLGIVVVNSP 124 Query: 99 AYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGK---- 154 + + A AEH I ++M + R I A + + G + GKT +IG GK Sbjct: 125 SGNIGAAAEHTIALLMAMARNIPEACSSLKSGKWERSKFVGVEVKGKTLSIIGLGKGELL 184 Query: 155 -----------------------IGVAMLRILKGFGMRLLAFDPYPSAAALELGV-EYVD 190 +G+ + R+ KG GM + A DPY S A V Sbjct: 185 AIWGRGIHFRYDGGSSGWADRQTVGLTVARLAKGLGMHVNALDPYASPAVAASASVTLVS 244 Query: 191 -LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKN 249 L L +D +++H PL +++ A QMK G I+N +RG ID A +E+L++ Sbjct: 245 SLSELLPTADFLTIHTPLIASTKGMISTAELAQMKPGARILNVARGGTIDEAALLESLES 304 Query: 250 QKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQ 309 + + +DV+ E + RL A + T H T EA ++S Sbjct: 305 GHLAAAAIDVFTTEPPQ----------PESTAARLVAHPRAVVTPHLGASTVEAQENVSI 354 Query: 310 TTLQNLSNLEKGETCPNEL 328 + + + G + + Sbjct: 355 DVCEQVLQILNGSLPRSAV 373 >UniRef50_D1CE36 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=2 Tax=Bacteria RepID=D1CE36_THET1 Length = 324 Score = 339 bits (871), Expect = 8e-92, Method: Composition-based stats. Identities = 87/330 (26%), Positives = 146/330 (44%), Gaps = 19/330 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K+ + + D Q++ E G ++ L E+ A A+ + + V+ Sbjct: 5 KVLITDAEYPDLSDEQRLLEEAGCQVSIAQCRLPEEVILAARDAFALMV-QYAPITSDVI 63 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 L +K I+ G ++VDLDAAKE G+ V VP Y VA HA M+++L R + Sbjct: 64 HALP--NLKLISRAGVGVDSVDLDAAKEKGVWVANVPDYGVHEVASHAAAMILSLLRHVC 121 Query: 122 RAYQRTRDANFSL-EGLTGFTMYGKTAGVIGTGKIGVAMLRIL-KGFGMRLLAFDPYPSA 179 ++ R+ + + T GV+G G+IG + ++ FG R++ +DPY A Sbjct: 122 FLDRKVREGVWHYLSTGEIHRISSLTLGVVGLGRIGRTLASMMLHVFG-RVIGYDPYLPA 180 Query: 180 AALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALID 239 A GV+ VDL LF +S+V+SLH PLT E +++N M G +VNT+RG L++ Sbjct: 181 NAWPEGVDRVDLRDLFMKSNVVSLHLPLTKETSNMVNREFLALMPVGSYLVNTARGGLVN 240 Query: 240 SQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFL 299 + I L + + +DV E + + + T H A+ Sbjct: 241 MEDLIYFLDSGHLAGAALDVLPKEPPVAGDPIIHHPKIII-------------TPHVAWY 287 Query: 300 TAEALTSISQTTLQNLSNLEKGETCPNELV 329 + E+ + N+ K + +V Sbjct: 288 SEESEKELRYKWAMNVVAFLKNGSPLYPVV 317 >UniRef50_Q8CPW2 Glycerate dehydrogenase n=6 Tax=Staphylococcus RepID=Q8CPW2_STAES Length = 323 Score = 339 bits (871), Expect = 8e-92, Method: Composition-based stats. Identities = 86/334 (25%), Positives = 141/334 (42%), Gaps = 22/334 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFL--LTEKTAKTANGCEAVCIFVNDDGSR 58 M + T+Q + Y++Q+ + + D E A I +++ Sbjct: 1 MN-KILVTRQIPQHYVEQLKKIGQVVMWEHDLTPMSRESFLANVEDATACVITLSEHIDE 59 Query: 59 PVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNR 118 V L+ +K IA GF+N+D+ AK+ G+ V P E AE +M+T+ R Sbjct: 60 EVF--LRAQQLKVIANMAVGFDNIDISLAKKHGVVVTNTPHVLTETTAELGFTLMLTVAR 117 Query: 119 RIHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 RI A ++ + G L+G +YG T G+ G G IG A R L+GF R++ + Sbjct: 118 RIIEATSYIQEGKWKSWGPYLLSGKDVYGATVGIFGMGDIGKAFARRLQGFDARIIYHNR 177 Query: 176 YPS-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 A +L YV +L +SD I PLT E + + AF +MKN + +N R Sbjct: 178 KRDLNAERDLNATYVTFKSLLEQSDFIICTAPLTKETENQFDARAFNKMKNDAVFINIGR 237 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 GA++D +A +EALKN +I + G+DV E + N + Sbjct: 238 GAIVDEEALLEALKNHEIQACGLDVMRQEPIQ-------------PNHPILKLPNAVVLP 284 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H + + Q + N+ + + + Sbjct: 285 HIGSASQVTRNRMVQLCIDNIKAVLNNDAPITPV 318 >UniRef50_C0QQQ9 Glycerate dehydrogenase (NADH-dependent hydroxypyruvatereductase) (Hpr) (Gdh) (Hydroxypyruvate dehydrogenase) (Glyoxylatereductase) (Hpr-a) n=31 Tax=Bacteria RepID=C0QQQ9_PERMH Length = 321 Score = 339 bits (871), Expect = 8e-92, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 131/337 (38%), Gaps = 29/337 (8%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ K V E+FG + + + + + I R V Sbjct: 1 MKIVFLDAKTVGDDIDLSVFEAFG-DFIAYPTTKGSEVFDRVYDAD-IIITNKVIIDREV 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 ++ + +K I + G NNVD+ AKE G+ V V Y E+V +H M+ + ++ Sbjct: 59 IDYARD--LKLICVAATGTNNVDILYAKEKGIAVTNVAGYSTESVVQHTFAMLFYILEQL 116 Query: 121 HRAYQRTRDANFSLEGLTGF------TMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 + ++ + + GK G+IG G IG + ++ + FG ++ Sbjct: 117 RYYDDYVKSGQYAESDIFTHLGRPFSEINGKRWGIIGLGTIGRRVGQVAESFGCDVIYHS 176 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 S E L L SD++S+H PL + +L+ MK +++N R Sbjct: 177 T--SGVKREERYREYPLDELLKTSDIVSIHAPLNEKTRNLITYDKISLMKPSAILLNLGR 234 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHN---VL 291 G +++ + AL I G+DV E E D + L + N +L Sbjct: 235 GGIVNEEDLARALDEGLISGAGLDVLEKEPI-------------DPYSPLLSIKNRDRLL 281 Query: 292 FTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T H A+ + EA + Q +N+ G+ N + Sbjct: 282 ITPHIAWTSIEARKRLIQEIAENIRAFLNGKE-RNRV 317 >UniRef50_C1SG57 Lactate dehydrogenase-like oxidoreductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SG57_9BACT Length = 314 Score = 339 bits (871), Expect = 9e-92, Method: Composition-based stats. Identities = 84/332 (25%), Positives = 147/332 (44%), Gaps = 23/332 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ + + +D ++ + + L ++ AK A + + ++D R + Sbjct: 1 MKILITAELPFD---IEGYLKGHELDYNKGKQLSAKELAKRAEDADGIISMLSDKIDREL 57 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E K +K +A G+NN+D+ AA ELG+ V P + AE +M+T RR+ Sbjct: 58 MESCK--NLKVVANYAVGYNNIDVQAASELGITVCNTPDVLTQTTAELGFALMITAARRV 115 Query: 121 HRAYQRTRDAN---FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 TR+ + + G M+GKT GV G G+IG A+ ++ GF M ++ Sbjct: 116 SEGDAFTRNKKFKGWEADLFLGMDMHGKTLGVFGFGRIGQAVAQMASGFNMDIIYSSRTK 175 Query: 178 SAAALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A L G V L +SD + + P TPE +H F QMK+ ++VN RG Sbjct: 176 KHQAELLTGASRVSFDDLVRQSDFLIITAPSTPETHHKFTLETFVQMKSSAVLVNIGRGD 235 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +I + ++AL+N+ I + G+DVYE+E + L N + H Sbjct: 236 IIKERDLVKALENKLIFAAGLDVYEDEPKIDAG--------------LFKLSNAVLAPHI 281 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 + ++++ ++++ K E L Sbjct: 282 GSGSFATREAMAKMCCDAVTSVFKDEKPACAL 313 >UniRef50_B3E5B4 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=21 Tax=Bacteria RepID=B3E5B4_GEOLS Length = 332 Score = 339 bits (870), Expect = 9e-92, Method: Composition-based stats. Identities = 88/306 (28%), Positives = 143/306 (46%), Gaps = 23/306 (7%) Query: 29 FFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAK 88 +D E + A G E V + + +L++L G+++I+L G+NNVD++AA Sbjct: 33 IYDRTPAELVLERAAGAE-VILTSKVKLTAAILQQLP--GLRFISLLATGYNNVDVEAAG 89 Query: 89 ELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSL------EGLTGFTM 142 LG+ V VPAY ++VA+ +++ L Q + + + Sbjct: 90 RLGITVSNVPAYSTDSVAQTTFALLLELTTHAGLHDQAVKQGEWVRSPDHSFWKRPIVEL 149 Query: 143 YGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVIS 202 G T G++G G IG A+ RI FGM+++A+ P P AA V +V L LF ++DV+S Sbjct: 150 AGLTLGIVGFGAIGRAVARIGSAFGMQVVAYTPRPPAATEFPLVRFVSLDELFGQADVVS 209 Query: 203 LHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYEN 262 L+CP T EN +N E+MK ++N +RG L++ AL++ I G+DV Sbjct: 210 LNCPQTTENGGFVNAVLLERMKRSAFLINVARGGLVNESDLAAALRDGVIAGAGLDVVSV 269 Query: 263 ERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGE 322 E L L N +FT H A+ + A ++ NL+ +G+ Sbjct: 270 EPML-------------PENPLLQAPNCIFTPHIAWASLAARQRLTAIVAANLAGYLQGK 316 Query: 323 TCPNEL 328 N + Sbjct: 317 -PINVV 321 >UniRef50_D2RN56 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RN56_ACIFE Length = 319 Score = 339 bits (870), Expect = 9e-92, Method: Composition-based stats. Identities = 92/325 (28%), Positives = 148/325 (45%), Gaps = 20/325 (6%) Query: 4 AVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEE 63 + K K ++ G+EL + AK +AV + ++ V++ Sbjct: 3 KILVPKAL-KPVAREFLTKKGYELVSPEATDEASLAKAIADVDAVIAR-TEKYTKTVVDA 60 Query: 64 LKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRA 123 K +K IA G+ N+DL A + V + +VAEHAI +M+ R+I + Sbjct: 61 GK--NLKIIARYGIGYENIDLAACDAKNVTVTLARGCNTYSVAEHAISLMLACFRQIPQL 118 Query: 124 YQRTRDANF-SLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPSAAA 181 Q R N+ S + + KT G IG G IG+ ++I GF MR+L +D + + Sbjct: 119 NQEVRKGNWKSRDAIETHEARYKTFGSIGIGPIGLEAVKIAHFGFQMRILVYDKFVDRSQ 178 Query: 182 LELGVEYVD-LPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 VE+VD L L ++DV+S H PL +H+++E A MK +++N SRGA+ D Sbjct: 179 FPDWVEFVDTLDELMEQADVVSPHLPLNKGTFHIIDEEAISHMKPTAVLLNVSRGAIWDE 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A +ALK +I + G DV+E E L + N + H A LT Sbjct: 239 KAVYKALKEGRIAAAGADVFETEPPT-------------PDMPLFSLPNYIGCPHTAALT 285 Query: 301 AEALTSISQTTLQNLSNLEKGETCP 325 EA+ +++ Q + +L G Sbjct: 286 EEAVDAVAMNCAQAIDDLLNGREPK 310 >UniRef50_B2A705 D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A705_NATTJ Length = 331 Score = 339 bits (870), Expect = 9e-92, Method: Composition-based stats. Identities = 89/334 (26%), Positives = 151/334 (45%), Gaps = 22/334 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELE--FFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 VY T + L + E F + ++ + A +A+ + D + V Sbjct: 5 PKVYVTSNIPEAGLTLLKEKFKLNFHQPLGQQITEDELIEAAKSHDALITTLTDPVTERV 64 Query: 61 LEELKKHG-VKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + G +K +A AG++N+ +DA ++V P E A+ ++M + RR Sbjct: 65 AAAGQNGGKLKVVANYGAGYDNIAVDAFSNADIRVTNTPGVLHETTADLTFALIMGIARR 124 Query: 120 IHRAYQRTRDAN---FSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP- 175 I+ A + R + + L G ++ +T G+IG G+IG A+ + GF M ++ ++ Sbjct: 125 INEAEKFLRSGQFQGWKPDLLLGEDVHDRTIGIIGMGEIGQAVAKRALGFNMEVIYYNRS 184 Query: 176 YPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 Y S EL +Y L L SESD +S+H PLT H++ F QMKN ++NTSR Sbjct: 185 YLSQEREQELQAQYKSLEELLSESDFVSIHVPLTNNTQHMITAKEFSQMKNSAFLINTSR 244 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +ID QA ++ALK +I +DV+E E +V L + L Sbjct: 245 GPVIDEQALVDALKTGEIQGAALDVFEKEP--------------EVHPELLDRQDCLLVP 290 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T + ++S+ +N+ + G+ P + Sbjct: 291 HIGSATHKCRNNMSEMACKNVEAVLDGQEPPTPV 324 >UniRef50_A1ZX42 Glycerate dehydrogenase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZX42_9SPHI Length = 316 Score = 339 bits (870), Expect = 1e-91, Method: Composition-based stats. Identities = 82/334 (24%), Positives = 140/334 (41%), Gaps = 26/334 (7%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 MK+ V + L E+ + EK + + + + Sbjct: 1 MKIVVVDGHALNPGDLDWTPFEAFGEVTVYARTPQEKLVERCQNAD-IVLTNKARFDSAT 59 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L +L +KYI + G++ +DL AK + V +PAY AVA+H +M+ L R+ Sbjct: 60 LLQL--THLKYIGVLATGYDLIDLKTAKASNIVVTNIPAYGDVAVAQHTFALMLELINRV 117 Query: 121 HRAYQRTRDANFSL------EGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFD 174 Q + ++ T+ G G+IG GKIG + + K FGMR+ + Sbjct: 118 SLHDQSVKSGEWAKNPDWCYWKAPFHTLNGMRLGIIGFGKIGRKVAEVAKAFGMRMFYNN 177 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + +Y + +F + D+++LH PL +N +N+ +M++ +++NTSR Sbjct: 178 LSKK---TNIYAQYAEKEEIFEKCDIVTLHLPLDKDNKGFVNKELLSRMQSSALLINTSR 234 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G LI+ Q +AL + +I G+DV E L NVL T Sbjct: 235 GGLINEQDLADALNSGQIAGAGLDVLATEPPQ-------------ADHPLFKAKNVLITP 281 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H A+ E+ ++ L N+ N +G T N + Sbjct: 282 HMAWGAVESRNALMNEALDNVKNFVEG-TPQNVV 314 >UniRef50_A6TL35 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=27 Tax=Bacteria RepID=A6TL35_ALKMQ Length = 743 Score = 339 bits (870), Expect = 1e-91, Method: Composition-based stats. Identities = 98/332 (29%), Positives = 162/332 (48%), Gaps = 20/332 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEF-FDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K VY T+ + L+ + E E++ + L ++ + +A+ + + Sbjct: 3 KPKVYVTRPLPTEALRLLKERCDVEMKRDSENLSKKELLEKLKKYDAILV-SGTKIDEEI 61 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 E + + K +A G++N+D+DAA + G+ V P EA A+ A G+++ RRI Sbjct: 62 CEAI-QFKCKILANYGVGYDNIDVDAATKYGIYVSNNPNAVTEATADLAWGLILATARRI 120 Query: 121 HRAYQRTRDA--NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPS 178 Q R N+ L G + GKT G+IG G+IG A+ + KGF M ++ P P Sbjct: 121 VECDQYIRSGQKNWGPINLLGSQVSGKTIGIIGGGRIGTAVGQRAKGFNMNIIYTGPKPK 180 Query: 179 AAALEL-GVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 A E G +YVD TL E+D +S+H PL HL+ + MK+ +++NTSRG+L Sbjct: 181 ATFEEATGGKYVDKETLLREADFVSIHVPLLSSTKHLIGTDELKLMKDTAILINTSRGSL 240 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 ID +A ++AL N +IG G+DV+E E + + L V+ T H Sbjct: 241 IDEKALVKALHNNEIGGAGLDVFEQEPVVERD--------------LLDIKKVVLTPHVG 286 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 T + + +T +N+ ++ G+ PN +V Sbjct: 287 TSTLDTRIEMGETCARNIFSVLDGKAPPNCVV 318 >UniRef50_A1R7L8 D-3-phosphoglycerate dehydrogenase n=35 Tax=Actinobacteria (class) RepID=A1R7L8_ARTAT Length = 539 Score = 338 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 89/328 (27%), Positives = 146/328 (44%), Gaps = 19/328 (5%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V ++ ++ + FE+ D + +A+ + + Sbjct: 13 KPVVLLAEELSPATVEAL--GPDFEIRQTDGADRSQLLSAIADVDAILVRSATQVDAEAI 70 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 K +K IA G +NVD+ +A + G+ VV P + + AE +G +++L R I Sbjct: 71 AAAK--NLKVIARAGVGLDNVDIKSATQAGVMVVNAPTSNIVSAAELTVGHILSLARHIP 128 Query: 122 RAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA- 180 +A ++ + TG ++ K G+IG G+IG + L+GF +LA+DPY +AA Sbjct: 129 QASSALKNGEWKRSKYTGIELFEKKIGIIGLGRIGALVAARLQGFETEILAYDPYITAAR 188 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 A +LGV+ V L L SD I++H P TPE +L AF +MK ++N +RG L+D Sbjct: 189 AAQLGVKLVTLDELLENSDFITIHMPKTPETVGMLGADAFRKMKESAYVINVARGGLVDE 248 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 +A ALK +I G+DV+ E NV+ T H T Sbjct: 249 EALYTALKEGQIAGAGVDVFVKEP--------------STDLPFFEFDNVVVTPHLGAST 294 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 EA + +++ GE P+ + Sbjct: 295 DEAQEKAGVSVAKSVRLALAGELVPDAV 322 >UniRef50_B2UXX3 D-lactate dehydrogenase n=2 Tax=Clostridium RepID=B2UXX3_CLOBA Length = 328 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 117/328 (35%), Positives = 194/328 (59%), Gaps = 2/328 (0%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M++ ++T+ +K + ++ +++ + LT +T A G + V + N D + V Sbjct: 1 MEIIAFATRPDEKAGFDKFSKELNIKVKNINERLTLETVHEARGFKFVSVLGNCDVNSEV 60 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE+L + GV+YIA R AG+NN+D+ AKELG+ + Y P+ VA+ A+ +M+ R++ Sbjct: 61 LEKLNEFGVEYIASRSAGYNNIDIKKAKELGIGISNA-NYSPKCVADFAVMLMLMCIRKV 119 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 +R R ++S+ GL G M+ GVIGTGKIG A+++ L GFG ++LA+D Y + + Sbjct: 120 VWGLERARVNDYSVIGLQGKEMHNLVVGVIGTGKIGQAVIKNLSGFGCKILAYDIYENES 179 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + V+YVD+ TL+ E D+I++H PL NY+L+N+ + +MK+GV+I+NTSRG LI++ Sbjct: 180 MKKY-VQYVDMDTLYKECDIITIHSPLFDSNYNLINKESMRKMKDGVVIINTSRGELINT 238 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 + IEAL K+G++G+DV ENE +F D + + L NV+ T H AF T Sbjct: 239 RDLIEALDKGKVGAVGLDVLENEVGIFHSDCRFTGVNNKDIIMLKQMKNVILTHHFAFYT 298 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 +A+ + L++L P + Sbjct: 299 DQAVYDMVGCALKSLRAFHDKIKNPYII 326 >UniRef50_Q59516 Glycerate dehydrogenase n=35 Tax=Proteobacteria RepID=DHGY_METEA Length = 314 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 87/333 (26%), Positives = 151/333 (45%), Gaps = 29/333 (8%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVL 61 K V+ ++ +++ N ++ E+ E+ + G E I L Sbjct: 3 KKVVFLDRESLDATVREFNFPHEYK-EYESTWTPEEIVERLQGAEIAMI-NKVPMRADTL 60 Query: 62 EELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIH 121 ++L +K IA+ G + VD AAK G+ VV + Y V EH +G+M L R I Sbjct: 61 KQLPD--LKLIAVAATGTDVVDKAAAKAQGITVVNIRNYAFNTVPEHVVGLMFALRRAIV 118 Query: 122 RAYQRTRDANFSLE------GLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R +++ + + G T G+IG G +G ++ + + GM++LAFD Sbjct: 119 PYANSVRRGDWNKSKQFCYFDYPIYDIAGSTLGIIGYGALGKSIAKRAEALGMKVLAFDV 178 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 +P VDL T+ ++SDVI+LH PLTP+ +++ ++MK +++NT+RG Sbjct: 179 FPQDG-------LVDLETILTQSDVITLHVPLTPDTKNMIGAEQLKKMKRSAILINTARG 231 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D A ++ALK+ IG G DV E + N++ T H Sbjct: 232 GLVDEAALLQALKDGTIGGAGFDVVAQEPPKDGNILCDA-----------DLPNLIVTPH 280 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ + EA+ ++ + N+ G+ N + Sbjct: 281 VAWASKEAMQILADQLVDNVEAFVAGK-PQNVV 312 >UniRef50_A7ZTA0 Glyoxylate/hydroxypyruvate reductase B n=224 Tax=Proteobacteria RepID=GHRB_ECO24 Length = 324 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 85/334 (25%), Positives = 148/334 (44%), Gaps = 22/334 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFG-FELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK +V K LQ++ E F ++ E+ A E + N++ Sbjct: 1 MKPSVILYKALPDDLLQRLQEHFTVHQVANLSPQTVEQNAAIFAEAEGLL-GSNENVDAA 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +LE++ K ++ + G++N D+DA + ++ P E VA+ + ++++ RR Sbjct: 60 LLEKMPK--LRATSTISVGYDNFDVDALTARKILLMHTPTVLTETVADTLMALVLSTARR 117 Query: 120 IHRAYQRTRDANFSLE---GLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDP 175 + +R + ++ G ++ KT G++G G+IG+A+ + GF M +L Sbjct: 118 VVEVAERVKAGEWTASIGPDWYGTDVHHKTLGIVGMGRIGMALAQRAHFGFNMPILYNAR 177 Query: 176 YPSAAALE-LGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 A E Y DL TL ESD + L PLT E +HL F +MK+ + +N R Sbjct: 178 RHHKEAEERFNARYCDLDTLLQESDFVCLILPLTDETHHLFGAEQFAKMKSSAIFINAGR 237 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D A I AL+ +I + G+DV+E E V L + NV+ Sbjct: 238 GPVVDENALIAALQKGEIHAAGLDVFEQEPLS-------------VDSPLLSMANVVAVP 284 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E ++ + NL + +G+ N + Sbjct: 285 HIGSATHETRYGMAACAVDNLIDALQGKVEKNCV 318 >UniRef50_A7VWU5 Putative uncharacterized protein n=1 Tax=Clostridium leptum DSM 753 RepID=A7VWU5_9CLOT Length = 321 Score = 338 bits (867), Expect = 3e-91, Method: Composition-based stats. Identities = 91/336 (27%), Positives = 154/336 (45%), Gaps = 25/336 (7%) Query: 1 MKLAVYSTKQYDK---KYLQQVNESFGFELEFFDF---LLTEKTAKTANGCEAVCIFVND 54 MK V ST K +++ E GFE+ + + ++ I D Sbjct: 1 MKKKVLSTVTLYSQRCKSAKELLEKEGFEVIEYQGDTVMTADEIKAVGKDICGAII-GCD 59 Query: 55 DGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMM 114 + + + + +K I G+NN+DL+AAK G+KV + ++VAE+ I +++ Sbjct: 60 EWNEEIFQACP--NLKAIGRFGVGYNNIDLEAAKRHGVKVSIATGINADSVAENTILLVL 117 Query: 115 TLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFG-MRLLAF 173 R + R + + TG + K G++G G I + +++K FG R++A+ Sbjct: 118 ASLRDLVNLDNAVRRGEWVRDS-TGRIIRNKVYGLVGFGAIARYVAKLVKAFGPARIIAY 176 Query: 174 DPYPS-AAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 D YP+ A +LGVE VD T+ ESD+IS+H P TPE Y + E F+ MK+ + VN Sbjct: 177 DKYPNYEEAEKLGVEIVDFDTVVKESDIISVHVPATPETYKMFGEKEFKAMKDSAVFVNV 236 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG+++D A +ALK + I DV+E E L N++ Sbjct: 237 ARGSVVDEAAMYKALKEKWIARAATDVFEEEP-------------TPKDNPLFELDNIVM 283 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E ++ + Q + ++ G+ N + Sbjct: 284 MPHMCGDTWETFEAVGLFSAQVIIDVMNGKDPKNWI 319 >UniRef50_Q3KHS7 2-ketogluconate reductase n=24 Tax=Proteobacteria RepID=Q3KHS7_PSEPF Length = 326 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 142/334 (42%), Gaps = 23/334 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFEL-EFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK V + + ++++ + F + + + + + + + Sbjct: 3 MKKTVLAFSRITPPMIERLQQDFDVIVPNPKNGDINAQFNEALPHAHGLIGVGR-KLGKA 61 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 LE K ++ ++ G++N DL E G+ + P E+ A+ A ++M+ RR Sbjct: 62 QLENAAK--LEVVSSVSVGYDNYDLAYFNERGIMLTNTPDVLTESTADLAFALIMSSARR 119 Query: 120 IHRAYQRTRDANFSLE---GLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAF-D 174 + T+ + L G ++GKT G++G G IG A+ R + GF M ++ + Sbjct: 120 VAELDAWTKAGQWQASVGAPLFGCDVHGKTLGIVGMGNIGAAVARRGRFGFNMPIIYSGN 179 Query: 175 PYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 + ELG ++ L L +E+D + L PL+ + HL++ MK ++VN SR Sbjct: 180 SRKTELEQELGAQFRSLDQLLAEADFVCLVVPLSDKTRHLISHRELALMKPDAILVNISR 239 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G ++D A IEAL+N +I G+DVYE E L N + Sbjct: 240 GPVVDEPALIEALQNNRIRGAGLDVYEKEPL--------------AESPLFQLKNAVTLP 285 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T E +++ L NL + GE + + Sbjct: 286 HIGSATNETREAMANRALTNLRSALLGERPQDLV 319 >UniRef50_Q0ADX2 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding n=2 Tax=Nitrosomonas RepID=Q0ADX2_NITEC Length = 322 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 137/330 (41%), Gaps = 24/330 (7%) Query: 1 MKLAVYSTKQYDKKYLQQV-NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 M + + + E + D E+ + G E + I R Sbjct: 1 MLTVFLDFGSVTRGDIDRAALEQAVSPWIYHDNTSREQVTERIKGAE-IIISNKVQLDRT 59 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 + +K I + G+NNVDL AA E + V V Y +VA+H + M+ R Sbjct: 60 AIFAA--DQLKLICVAATGYNNVDLAAAAERNIPVCNVRNYATSSVAQHTLMFMLNFACR 117 Query: 120 IHRAYQRTRDANFSLEGLTG------FTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAF 173 Q + + + GKT G+IG G++G A+ I K FGM+LL Sbjct: 118 FVEYRQLIKKGGWQTSTYFCPLDFGVMELAGKTLGIIGHGELGSAVANIAKAFGMKLLIA 177 Query: 174 DPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTS 233 Y SA+++ G + + ++D I+LHCPL+ + HL+ + F+ MK V ++NT+ Sbjct: 178 -EYKSASSIRPG--RMAFNDVIQQADFITLHCPLSADTRHLIGKWEFDLMKPSVYLINTA 234 Query: 234 RGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFT 293 R LI+ ++AL + +I +DV + E + + N+L T Sbjct: 235 RSGLINEDDLLQALYSGRIAGAAIDVLQAEPPVNGNPLLDYP-----------HPNLLIT 283 Query: 294 GHQAFLTAEALTSISQTTLQNLSNLEKGET 323 H A+ + E+ + N+ N + + Sbjct: 284 PHSAWASVESRQRMINLLADNIRNFLQNKP 313 >UniRef50_A5VTC2 D-isomer specific 2-hydroxyacid dehydrogenases family protein n=153 Tax=cellular organisms RepID=A5VTC2_BRUO2 Length = 360 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 76/337 (22%), Positives = 140/337 (41%), Gaps = 21/337 (6%) Query: 2 KLAVYSTKQYDKKYLQQVNESFGFELEFFDF-LLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K V T++ ++ E F L D + + + + + D V Sbjct: 32 KPMVVLTRKLPDPVETRMRELFDARLNIDDHRMSQPEIIAALKEADVLVPCITDVIDAAV 91 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 +E+ +K IA G +N+D+ AA G+ V P E A+ + +++++ RR+ Sbjct: 92 IEQAG-PNLKLIANFGNGVDNIDVAAAARRGITVTNTPNVLTEDTADMTLALLLSVPRRL 150 Query: 121 HRAYQRT--RDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R + + G ++GK G++G G+IG A+ R K FG+ + + Sbjct: 151 VEGANVINERHGQWPGWSPTWMLGRRIWGKRLGIVGMGRIGTAVARRAKAFGLSIHYHNR 210 Query: 176 YP--SAAALELGVEY-VDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNT 232 EL Y L + + D+IS++CP TP +HLL+ M+ +VNT Sbjct: 211 KRVSPQVEEELEATYWDSLDQMLARMDIISVNCPSTPATFHLLSARHIALMQPTAYLVNT 270 Query: 233 SRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLF 292 +RG +ID A I+ ++ ++ G+DV+E+E + + L+ V+ Sbjct: 271 ARGQIIDENALIDLIEEGRLAGAGLDVFEHEPAV-----------NPRLLALAEKGKVVL 319 Query: 293 TGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV 329 H T E + + N+ G P+ ++ Sbjct: 320 LPHMGSATIEGRIDMGDKVIINIRAFVDGHRSPDRVL 356 >UniRef50_B6WY27 Putative uncharacterized protein n=1 Tax=Desulfovibrio piger ATCC 29098 RepID=B6WY27_9DELT Length = 320 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 92/333 (27%), Positives = 141/333 (42%), Gaps = 23/333 (6%) Query: 1 MKLAVYSTKQYDKKYLQQV-NESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRP 59 MK+ V + + E G E+ + + A G E V + Sbjct: 1 MKIVVLDGDVINPGDISWAPLEKLG-EVVIHGHTPEDMIVERAAGAE-VLVTNKVPLRAA 58 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 L L ++ +A+ G++ +D A G+ V V AY + VA+HA +++ L RR Sbjct: 59 TLSHLPD--LRMVAVLATGYDIIDTADAAAHGIPVCNVVAYGVDDVAQHAWALLLELCRR 116 Query: 120 IHRAYQRTRDANFS----LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDP 175 R + T + G+T GVIG G IG + + FGM +LA Sbjct: 117 TSDHTASVRAGEWKDTWCYWKTTPVCLRGRTLGVIGFGSIGRRVGELGHAFGMSVLANCR 176 Query: 176 YPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRG 235 P + +F ++DVISLHCPLT ++N A +MK G +++NT+RG Sbjct: 177 TPRNPPSYSPFAFASTDQIFQQADVISLHCPLTDATGAIINAKALARMKPGAILINTARG 236 Query: 236 ALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGH 295 L+D A EAL + K+G LG+DV E L N L T H Sbjct: 237 PLLDEAAVAEALHSGKLGGLGVDVLAKEPPA-------------ADNPLLHTPNTLITPH 283 Query: 296 QAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ TA + +I T +N+ ++G T N + Sbjct: 284 MAWATARSRQNIINLTAENILRWQQG-TPVNVV 315 >UniRef50_C2BTH2 D-3-phosphoglycerate dehydrogenase n=1 Tax=Mobiluncus curtisii ATCC 43063 RepID=C2BTH2_9ACTO Length = 324 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 99/330 (30%), Positives = 156/330 (47%), Gaps = 24/330 (7%) Query: 2 KLAVY--STKQYDKKYLQQVNESFGFELEFFDFLLT---EKTAKTANGCEAVCIFVNDDG 56 KL V S + K+ +++ E G+E+ + ++ K A C V + DD Sbjct: 7 KLLVTPTSFASAELKFARKLLEESGYEVTYNQSGKPLDADQLVKAARDCVGVLAGL-DDF 65 Query: 57 SRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTL 116 S PVL +L ++ I+ G + VDL A + G+ V P + AVAE A+ M TL Sbjct: 66 STPVLNQLPD--LRVISRYGVGVDRVDLRTAGDNGVIVTNTPGANSTAVAEMALSSMFTL 123 Query: 117 NRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPY 176 R + + + TR + + G + T G++G G IG A+ R++ G M++L +DP+ Sbjct: 124 ARHVSQLNETTRRGQWLR--VVGTELSQATLGIVGYGSIGRALRRLVTGLEMKVLVYDPF 181 Query: 177 PSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 V+ V+L L ES+ ISLH PLTP HL +++ F M G ++NTSRG Sbjct: 182 FDPDTDPT-VQGVELAELVRESNFISLHLPLTPATEHLFDDSMFRLMSPGTFLINTSRGG 240 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 +ID AA+ AL+ ++ L +D YE E L NV+ T H Sbjct: 241 IIDESAAVVALEAGQLAGLALDAYEQEPPS-------------PEHELFRFSNVIATPHS 287 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGETCPN 326 T ++ +++ + NL GE+ N Sbjct: 288 GAQTVQSRIRMARGAVDNLLRALAGESVTN 317 >UniRef50_A1RDF9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Arthrobacter aurescens TC1 RepID=A1RDF9_ARTAT Length = 329 Score = 336 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 92/327 (28%), Positives = 149/327 (45%), Gaps = 14/327 (4%) Query: 5 VYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEEL 64 +Y + + L + ++ + + + + + V + +R ++E Sbjct: 4 IYISDVIHEDVLADIRKNAIVHVGYGPDKVN--YLDISENIDGVILRAET-FTREMIEAS 60 Query: 65 KKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAY 124 + +K IA G +NVD+ AA E + V P + AVAEH ++++L RRI A Sbjct: 61 PR--LKIIARHGVGTDNVDIPAASEHSVWVTSTPGSNSNAVAEHVFSLLLSLTRRIIPAA 118 Query: 125 QRTRDANFS--LEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAAL 182 R ++ L GF + G+T G++G G IG + I GFGMR+LA DP +AA Sbjct: 119 NRVLAGTWAEGRGDLVGFELSGRTLGIVGFGAIGKRVATIANGFGMRVLASDPIATAADA 178 Query: 183 ELGVE-YVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQ 241 E V+L TL+ +D+I+LH PL H+++ MK +I+NTSRG LID Sbjct: 179 EAAGAVLVELDTLYDGADIITLHAPLLSGTRHMISPRELAMMKPSAIIINTSRGGLIDED 238 Query: 242 AAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTA 301 A + AL N + +DV E E + +++ + L N+L T H A T Sbjct: 239 ALVTALTNGTLAGAALDVLEAESIDMKDPLTHNSV------PLHEVPNLLVTPHIAGQTQ 292 Query: 302 EALTSISQTTLQNLSNLEKGETCPNEL 328 EA + + + G T + Sbjct: 293 EAFQEAGTRSWSEVRAVLAGTTPAFPV 319 >UniRef50_P26297 D-lactate dehydrogenase n=73 Tax=Lactobacillales RepID=LDHD_LACDA Length = 333 Score = 336 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 107/328 (32%), Positives = 172/328 (52%), Gaps = 1/328 (0%) Query: 2 KLAVYSTKQYDKKYLQQVNESF-GFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 K+ Y+ ++ +K +L++ ++ E+E+ D LLT +T A G + V ++ D + Sbjct: 3 KIFAYAIREDEKPFLKEWEDAHKDVEVEYTDKLLTPETVALAKGADGVVVYQQLDYTAET 62 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 L+ L +G+ ++LR G +N+D+ AKELG ++ VP Y P A+AEHA + R+ Sbjct: 63 LQALADNGITKMSLRNVGVDNIDMAKAKELGFQITNVPVYSPNAIAEHAAIQAARILRQD 122 Query: 121 HRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAA 180 ++ + G + + GVIGTG IG ++I++GFG +++A+D + + Sbjct: 123 KAMDEKVARHDLRWAPTIGREVRDQVVGVIGTGHIGQVFMQIMEGFGAKVIAYDIFRNPE 182 Query: 181 ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDS 240 + G L L+ ++DVISLH P P N H++N+ + +MK V+IVN SRG L+D+ Sbjct: 183 LEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESIAKMKQDVVIVNVSRGPLVDT 242 Query: 241 QAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLT 300 A I L + KI MDVYE E +F ED D L A NVL T H AF T Sbjct: 243 DAVIRGLDSGKIFGYAMDVYEGEVGIFNEDWEGKEFPDARLADLIARPNVLVTPHTAFYT 302 Query: 301 AEALTSISQTTLQNLSNLEKGETCPNEL 328 A+ ++ N L +G+ + Sbjct: 303 THAVRNMVVKAFDNNLELVEGKEAETPV 330 >UniRef50_UPI0001972FE9 D-isomer specific 2-hydroxyacid dehydrogenase family protein n=1 Tax=Clostridium sp. M62/1 RepID=UPI0001972FE9 Length = 338 Score = 336 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 91/331 (27%), Positives = 148/331 (44%), Gaps = 22/331 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPV 60 M + + + Q + E G+EL E + GC+A+ + + + Sbjct: 1 MSFRILLPQPILESGRQYLLER-GYELVDGSGFEEEDIIRDIRGCDAMIVR-TAKITDRI 58 Query: 61 LEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRI 120 LE + +K IA AGF+ VDL+AA++ G+ V+ P + ++VAE A+ ++ +R Sbjct: 59 LEAADR--LKVIARHGAGFDGVDLEAARKKGILVLYAPKANSQSVAELAVFYILHCSRNF 116 Query: 121 HRAYQRTRDA-NFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILK-GFGMRLLAFDPYPS 178 + RD F+ + + GKT G+IG G IG + + GF M+++AFDPY Sbjct: 117 KLVQKLYRDDYRFAKFNVEKHELNGKTLGLIGVGNIGGLVAKKAALGFDMKVIAFDPYAK 176 Query: 179 AAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGAL 237 L +E +F ++D +SLH P TPE + + E F MK ++NTSRG++ Sbjct: 177 E--LPDYIEVAESREEVFEKADYVSLHVPATPETVNSVGEKEFRLMKPTAFLINTSRGSV 234 Query: 238 IDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQA 297 +D +A I AL ++I +DV + E D L NV+ H Sbjct: 235 VDEEALIRALNEKEIAGAALDVLKQEPI-------------DKDNPLLEMDNVVTAPHIG 281 Query: 298 FLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 T EA S Q + + G + Sbjct: 282 AATKEASARASLICAQGIDDYLSGRKPEFVV 312 >UniRef50_A4YUP8 Putative D-3-phosphoglycerate dehydrogenase (PGDH) n=4 Tax=Proteobacteria RepID=A4YUP8_BRASO Length = 335 Score = 336 bits (864), Expect = 6e-91, Method: Composition-based stats. Identities = 80/327 (24%), Positives = 142/327 (43%), Gaps = 20/327 (6%) Query: 1 MKLAVYSTKQYDKKYLQQVNESFGFELEFFDF-LLTEKTAKTANGC--EAVCIFVNDDGS 57 M+ + T + G L ++ A+ + + + Sbjct: 10 MRYKLLITGPALTAEATAIAARRGAALVDNPRYASPQELAEITAREQPDGIIVRQG-KID 68 Query: 58 RPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLN 117 V+ +K IA G++N+D++AA G+ V + ++VAE A +M + Sbjct: 69 DQVI--GASQKLKAIAKHGVGYDNIDVEAADRRGIPVFVARGANSQSVAELAFALMFAVA 126 Query: 118 RRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYP 177 R I R + ++ G + G++ GVIG G+IG ++ +++ M + FDPY Sbjct: 127 REIPHLDARIKTGHWDKATTKGAQLLGRSLGVIGFGEIGRILVGLVQPLHMEVRIFDPYM 186 Query: 178 SAAALELGVEYV-DLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGA 236 A A G E L + + SDVISLHCPL P+ +++ +M+ +++NT+RG Sbjct: 187 PADAEISGAERAGSLDEILTASDVISLHCPLMPQTRNMIGRDQLARMRRNAILINTARGG 246 Query: 237 LIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQ 296 LID A +AL++ I G+D + E L A NV+ T H Sbjct: 247 LIDEAALYDALRDGVIAGAGLDSFAEEPAK-------------PDLPLLALSNVVVTPHA 293 Query: 297 AFLTAEALTSISQTTLQNLSNLEKGET 323 T EA ++ + ++ ++ +G+T Sbjct: 294 GASTQEARDAMGVIAVNHVMDVLEGKT 320 >UniRef50_Q9UBQ7 Glyoxylate reductase/hydroxypyruvate reductase n=53 Tax=Eukaryota RepID=GRHPR_HUMAN Length = 328 Score = 336 bits (864), Expect = 6e-91, Method: Composition-based stats. Identities = 84/334 (25%), Positives = 148/334 (44%), Gaps = 22/334 (6%) Query: 3 LAVYSTKQYDKKYLQQVNESFGFELEFFDFLLT---EKTAKTANGCEAVCIFVNDDGSRP 59 + V+ T++ + + + E+E +D ++ + G + ++D + Sbjct: 7 MKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLSDHVDKR 66 Query: 60 VLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRR 119 +L+ +K I+ G +++ LD K+ G++V P + AE A+ +++T RR Sbjct: 67 ILDAAGA-NLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLLTTCRR 125 Query: 120 IHRAYQRTRDANFSLEG---LTGFTMYGKTAGVIGTGKIGVAMLRILKGFGM-RLLAFDP 175 + A + ++ ++ L G+ + T G+IG G+IG A+ R LK FG+ R L Sbjct: 126 LPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRFLYTGR 185 Query: 176 YPSAA-ALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSR 234 P A E E+V P L ++SD I + C LTP L N+ F++MK + +N SR Sbjct: 186 QPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVFINISR 245 Query: 235 GALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTG 294 G +++ +AL + KI + G+DV E L N + Sbjct: 246 GDVVNQDDLYQALASGKIAAAGLDVTSPEPL-------------PTNHPLLTLKNCVILP 292 Query: 295 HQAFLTAEALTSISQTTLQNLSNLEKGETCPNEL 328 H T ++S NL +GE P+EL Sbjct: 293 HIGSATHRTRNTMSLLAANNLLAGLRGEPMPSEL 326 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.315 0.196 0.664 Lambda K H 0.267 0.0600 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,845,463,989 Number of Sequences: 3077464 Number of extensions: 191634878 Number of successful extensions: 437503 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 4210 Number of HSP's successfully gapped in prelim test: 725 Number of HSP's that attempted gapping in prelim test: 420505 Number of HSP's gapped (non-prelim): 5366 length of query: 329 length of database: 1,040,396,356 effective HSP length: 129 effective length of query: 200 effective length of database: 643,403,500 effective search space: 128680700000 effective search space used: 128680700000 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 94 (40.3 bits)