Phyre 2 Results for P16918

Email	l.a.kelley@imperial.ac.uk
Description	P16918
Date	Wed Jan 25 15:20:40 GMT 2012
Unique Job ID	7f4c835c4cb93054

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2oy7A_

Top template information

PDB header:membrane protein
Chain: A: PDB Molecule:outer surface protein a;
PDBTitle: the crystal structure of ospa mutant

Confidence and coverage

Confidence:

96.0%

Coverage:

19%

269 residues ( 19% of your sequence) have been modelled with 96.0% confidence by the single highest scoring template.

You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.

3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M S G K P A A R Q G D M T Q Y G G S I V Q G S A G V R I G A P T G V A C S V C P G G V T S G H P V N P L L G A K V L P G

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
?
? ? ? ? ?
?
?
? ?
?
? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence E T D I A L P G P L P F I L S R T Y S S Y R T K T P A P V G S L G P G W K M P A D I R L Q L R D N T L I L S D N G G R S

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 130 . . . . . . . . . 140 . . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180

Sequence L Y F E H L F P G E D G Y S R S E S L W L V R G G V A K L D E G H R L A A L W Q A L P E E L R L S P H R Y L A T N S P Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210 . . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240

Sequence G P W W L L G W C E R V P E A D E V L P A P L P P Y R V L T G L V D R F G R T Q T F H R E A A G E F S G E I T G V T D G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280 . . . . . . . . . 290 . . . . . . . . . 300

Sequence A G R H F R L V L T T Q A Q R A E E A R Q Q A I S G G T E P S A F P D T L P G Y T E Y G R D N G I R L S A V W L T H D P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350 . . . . . . . . . 360

Sequence E Y P E N L P A A P L V R Y G W T P R G E L A A V Y D R S N T Q V R S F T Y D D K Y R G R M V A H R H T G R P E I C Y R

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence Y D S D G R V T E Q L N P A G L S Y T Y Q Y E K D R I T I T D S L N R R E V L H T Q G E G G L K R V V K K E H A D G S V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480

Sequence T Q S Q F D A V G R L R A Q T D A A G R T T E Y S P D V V T G L I T R I T T P D G R A S A F Y Y N H H S Q L T S A T G P

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 490 . . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540

Sequence D G L E I R R E Y D E W G R L I Q E T A P D G D I T R Y R Y D N P H S D L P C A T E D A T G S R K T M T W S R Y G Q L L

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 550 . . . . . . . . . 560 . . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600

Sequence S F T D C S G Y V T R Y D H D R F G Q V T A V H R E E G L S Q Y R A Y D S R G Q L I A V K D T Q G H E T R Y E Y N A A G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630 . . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660

Sequence D L T T V I A P D G S R N G T Q Y D A W G K A I C T T Q G G L T R S M E Y D A A G R V I R L T S E N G S H T T F R Y D V

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700 . . . . . . . . . 710 . . . . . . . . . 720

Sequence L D R L I Q E T G F D G R T Q R Y H H D L T G K L I R S E D E G L V T H W H Y D E A D R L T H R T V N G E T A E R W Q Y

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770 . . . . . . . . . 780

Sequence D E R G W L T D I S H I S E G H R V T V H Y G Y D S K G R L A S E H L T V H H P Q T N E L L W Q H E T R H A Y N A Q G L

Secondary structure

SS confidence

Disorder
? ? ?

Disorder confidence

. . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence A N R C I P D S L P A V E W L T Y G S G W L S G M K L G D T P L V E Y T R D R L H R E T L R S F G R Y E L T T A Y T P A

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900

Sequence G Q L Q S Q H L N S L L S D R D Y T W N D N G E L I R I S S P R Q T R S Y S Y S T T G R L T G V H T T A A N L D I R I P

Secondary structure

SS confidence

Disorder
?
?
?

Disorder confidence

. . . . . . . . . 910 . . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960

Sequence Y T T D P A G N R L P D P E L H P D S A L S M W P D N R I A R D A H Y L Y R Y D R H G R L T E K T D L I P E G V I R T D

Secondary structure

SS confidence

Disorder
? ?
?
? ? ? ?
?

Disorder confidence

. . . . . . . . . 970 . . . . . . . . . 980 . . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020

Sequence D E R T H R Y H Y D S Q H R L V H Y T R T Q Y A E P L V E S R Y L Y D P L G R R V A K R V W R R E R D L T G W M S L S R

Secondary structure

SS confidence

Disorder
?

Disorder confidence

. . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050 . . . . . . . . . 1060 . . . . . . . . . 1070 . . . . . . . . . 1080

Sequence K P Q V T W Y G W D G D R L T T I Q N D R T R I Q T I Y Q P G S F T P L I R V E T A T G E L A K T Q R R S L A D T L Q Q

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1090 . . . . . . . . . 1100 . . . . . . . . . 1110 . . . . . . . . . 1120 . . . . . . . . . 1130 . . . . . . . . . 1140

Sequence S G G E D G G S V V F P P V L V Q M L D R L E S E I L A D R V S E E S R R W L A S C G L T V A Q M Q S Q M D P V Y T P A

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?

Disorder confidence

. . . . . . . . . 1150 . . . . . . . . . 1160 . . . . . . . . . 1170 . . . . . . . . . 1180 . . . . . . . . . 1190 . . . . . . . . . 1200

Sequence R K I H L Y H C D H R G L P L A L I S T E G T T A W Y A E Y D E W G N L L N E E N P H Q L Q Q L I R L P G Q Q Y D E E S

Secondary structure

SS confidence

Disorder
?
? ?

Disorder confidence

. . . . . . . . . 1210 . . . . . . . . . 1220 . . . . . . . . . 1230 . . . . . . . . . 1240 . . . . . . . . . 1250 . . . . . . . . . 1260

Sequence G L Y Y N R H R Y Y D P L Q G R Y I T Q D P I G L K G G W N F Y Q Y P L N P I S N I D P L G L E T L K C I K P L H S M G

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 1270 . . . . . . . . . 1280 . . . . . . . . . 1290 . . . . . . . . . 1300 . . . . . . . . . 1310 . . . . . . . . . 1320

Sequence G T G E R S G P D I W G N P F Y H Q Y L C V P D G K G D Y T C G G Q D Q R G E S K G D G L W G P G K A S N D T K E A A G

Secondary structure

SS confidence

Disorder
? ? ? ? ? ? ? ? ? ?
? ?
?
?

Disorder confidence

. . . . . . . . . 1330 . . . . . . . . . 1340 . . . . . . . . . 1350 . . . . . . . . . 1360 . . . . . . . . . 1370 . . . . . . . . . 1380

Sequence R C D L V E T D N S C V E N C L K G K F K E V R P R Y S V L P D I F T P I N L G L F K N C Q D W S N D S L E T C K M K C

Secondary structure

SS confidence

Disorder
? ? ? ? ? ?
? ?
?
?
? ? ? ?
? ? ? ? ? ? ? ? ? ? ?
?

Disorder confidence

. . . . . . . . . 1390 . . . . . . .

Sequence S G N N I G R F I R F V F T G V M

Secondary structure

SS confidence

Disorder ? ? ?
? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2oy7 chain A

Region: 385 - 662
Aligned: 269
Modelled: 278
Confidence: 96.0%
Identity: 15%
PDB header:membrane protein
Chain: A: PDB Molecule:outer surface protein a;
PDBTitle: the crystal structure of ospa mutant

Phyre2

PDB 1n7d chain A

Region: 470 - 688
Aligned: 219
Modelled: 219
Confidence: 58.3%
Identity: 13%
PDB header:lipid transport
Chain: A: PDB Molecule:low-density lipoprotein receptor;
PDBTitle: extracellular domain of the ldl receptor

Phyre2

PDB 1adt chain A domain 1

Region: 1326 - 1389
Aligned: 53
Modelled: 60
Confidence: 45.4%
Identity: 34%
Fold: Domain of early E2A DNA-binding protein, ADDBP
Superfamily: Domain of early E2A DNA-binding protein, ADDBP
Family: Domain of early E2A DNA-binding protein, ADDBP

Phyre2

PDB 1x3z chain A domain 1

Region: 1209 - 1242
Aligned: 32
Modelled: 34
Confidence: 44.1%
Identity: 22%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Transglutaminase core

Phyre2

PDB 3ib5 chain A

Region: 1243 - 1363
Aligned: 104
Modelled: 118
Confidence: 41.3%
Identity: 18%
PDB header:hormone
Chain: A: PDB Molecule:sex pheromone precursor;
PDBTitle: crystal structure of sex pheromone precursor (yp_536235.1)2 from lactobacillus salivarius subsp. salivarius ucc118 at3 1.35 a resolution

Phyre2

PDB 2ivz chain D

Region: 385 - 626
Aligned: 238
Modelled: 242
Confidence: 37.7%
Identity: 13%
PDB header:protein transport/hydrolase
Chain: D: PDB Molecule:protein tolb;
PDBTitle: structure of tolb in complex with a peptide of the colicin2 e9 t-domain

Phyre2

PDB 3e5z chain A

Region: 426 - 703
Aligned: 256
Modelled: 262
Confidence: 26.6%
Identity: 15%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:putative gluconolactonase;
PDBTitle: x-ray structure of the putative gluconolactonase in protein family2 pf08450. northeast structural genomics consortium target drr130.

Phyre2

PDB 3msw chain A

Region: 926 - 975
Aligned: 34
Modelled: 34
Confidence: 25.6%
Identity: 21%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein;
PDBTitle: crystal structure of a protein with unknown function (bf3112) from2 bacteroides fragilis nctc 9343 at 1.90 a resolution

Phyre2

PDB 2w8b chain B

Region: 394 - 626
Aligned: 231
Modelled: 233
Confidence: 25.0%
Identity: 13%
PDB header:protein transport/membrane protein
Chain: B: PDB Molecule:protein tolb;
PDBTitle: crystal structure of processed tolb in complex with pal

Phyre2

PDB 3esw chain A

Region: 1209 - 1242
Aligned: 33
Modelled: 34
Confidence: 24.9%
Identity: 21%
PDB header:hydrolase
Chain: A: PDB Molecule:peptide-n(4)-(n-acetyl-beta-glucosaminyl)asparagine
PDBTitle: complex of yeast pngase with glcnac2-iac.

Phyre2

PDB 3rwx chain A

Region: 62 - 75
Aligned: 14
Modelled: 14
Confidence: 24.6%
Identity: 21%
PDB header:transport protein
Chain: A: PDB Molecule:hypothetical bacterial outer membrane protein;
PDBTitle: crystal structure of a hypothetical bacterial outer membrane protein2 (bf2706) from bacteroides fragilis nctc 9343 at 2.40 a resolution

Phyre2

PDB 2f4m chain A domain 1

Region: 1209 - 1242
Aligned: 34
Modelled: 34
Confidence: 24.5%
Identity: 24%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: Transglutaminase core

Phyre2

PDB 1j5q chain B

Region: 1189 - 1246
Aligned: 50
Modelled: 58
Confidence: 22.5%
Identity: 26%
PDB header:viral protein
Chain: B: PDB Molecule:major capsid protein;
PDBTitle: the structure and evolution of the major capsid protein of a large,2 lipid-containing, dna virus.

Phyre2

PDB 1osp chain O

Region: 366 - 558
Aligned: 175
Modelled: 193
Confidence: 22.1%
Identity: 17%
Fold: open-sided beta-meander
Superfamily: Outer surface protein
Family: Outer surface protein

Phyre2

PDB 2x12 chain A

Region: 1147 - 1172
Aligned: 26
Modelled: 26
Confidence: 21.7%
Identity: 27%
PDB header:cell adhesion
Chain: A: PDB Molecule:fimbriae-associated protein fap1;
PDBTitle: ph-induced modulation of streptococcus parasanguinis2 adhesion by fap1 fimbriae

Phyre2

PDB 3cbb chain A

Region: 1331 - 1358
Aligned: 17
Modelled: 28
Confidence: 19.7%
Identity: 18%
PDB header:transcription/dna
Chain: A: PDB Molecule:hepatocyte nuclear factor 4-alpha, dna binding
PDBTitle: crystal structure of hepatocyte nuclear factor 4alpha in2 complex with dna: diabetes gene product

Phyre2

PDB 3vh0 chain C

Region: 409 - 689
Aligned: 278
Modelled: 281
Confidence: 19.0%
Identity: 9%
PDB header:protein binding/dna
Chain: C: PDB Molecule:uncharacterized protein ynce;
PDBTitle: crystal structure of e. coli ynce complexed with dna

Phyre2

PDB 1hra chain A

Region: 1331 - 1358
Aligned: 17
Modelled: 28
Confidence: 17.4%
Identity: 18%
Fold: Glucocorticoid receptor-like (DNA-binding domain)
Superfamily: Glucocorticoid receptor-like (DNA-binding domain)
Family: Nuclear receptor

Phyre2

PDB 2cok chain A

Region: 1321 - 1351
Aligned: 31
Modelled: 31
Confidence: 16.2%
Identity: 3%
PDB header:transferase
Chain: A: PDB Molecule:poly [adp-ribose] polymerase-1;
PDBTitle: solution structure of brct domain of poly(adp-ribose)2 polymerase-1

Phyre2

PDB 1gib chain A

Region: 1376 - 1380
Aligned: 5
Modelled: 5
Confidence: 15.9%
Identity: 100%
PDB header:neurotoxin
Chain: A: PDB Molecule:mu-conotoxin giiib;
PDBTitle: mu-conotoxin giiib, nmr

Phyre2

Detailed template information

#	Template	Alignment Coverage	3D Model	Confidence	% i.d.	Template Information

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server

Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]

If you use the binding site predictions from 3DLigandSite, please also cite:

3DLigandSite: predicting ligand-binding sites using similar structures.

Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]

Imperial College London

Lawrence Kelley, Benjamin Jefferys

Disclaimer

Terms and Conditions

Component software

Template detection: HHpred 1.51

Secondary structure prediction: Psi-pred 2.5

Disorder prediction: Disopred 2.4

Transmembrane prediction: Memsat_SVM

Multi-template modelling and ab initio: Poing 1.0

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	S	G	K	P	A	A	R	Q	G	D	M	T	Q	Y	G	G	S	I	V	Q	G	S	A	G	V	R	I	G	A	P	T	G	V	A	C	S	V	C	P	G	G	V	T	S	G	H	P	V	N	P	L	L	G	A	K	V	L	P	G
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?		?	?	?	?	?			?			?		?	?			?		?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	E	T	D	I	A	L	P	G	P	L	P	F	I	L	S	R	T	Y	S	S	Y	R	T	K	T	P	A	P	V	G	S	L	G	P	G	W	K	M	P	A	D	I	R	L	Q	L	R	D	N	T	L	I	L	S	D	N	G	G	R	S
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence	L	Y	F	E	H	L	F	P	G	E	D	G	Y	S	R	S	E	S	L	W	L	V	R	G	G	V	A	K	L	D	E	G	H	R	L	A	A	L	W	Q	A	L	P	E	E	L	R	L	S	P	H	R	Y	L	A	T	N	S	P	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence	G	P	W	W	L	L	G	W	C	E	R	V	P	E	A	D	E	V	L	P	A	P	L	P	P	Y	R	V	L	T	G	L	V	D	R	F	G	R	T	Q	T	F	H	R	E	A	A	G	E	F	S	G	E	I	T	G	V	T	D	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence	A	G	R	H	F	R	L	V	L	T	T	Q	A	Q	R	A	E	E	A	R	Q	Q	A	I	S	G	G	T	E	P	S	A	F	P	D	T	L	P	G	Y	T	E	Y	G	R	D	N	G	I	R	L	S	A	V	W	L	T	H	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence	E	Y	P	E	N	L	P	A	A	P	L	V	R	Y	G	W	T	P	R	G	E	L	A	A	V	Y	D	R	S	N	T	Q	V	R	S	F	T	Y	D	D	K	Y	R	G	R	M	V	A	H	R	H	T	G	R	P	E	I	C	Y	R
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	Y	D	S	D	G	R	V	T	E	Q	L	N	P	A	G	L	S	Y	T	Y	Q	Y	E	K	D	R	I	T	I	T	D	S	L	N	R	R	E	V	L	H	T	Q	G	E	G	G	L	K	R	V	V	K	K	E	H	A	D	G	S	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence	T	Q	S	Q	F	D	A	V	G	R	L	R	A	Q	T	D	A	A	G	R	T	T	E	Y	S	P	D	V	V	T	G	L	I	T	R	I	T	T	P	D	G	R	A	S	A	F	Y	Y	N	H	H	S	Q	L	T	S	A	T	G	P
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence	D	G	L	E	I	R	R	E	Y	D	E	W	G	R	L	I	Q	E	T	A	P	D	G	D	I	T	R	Y	R	Y	D	N	P	H	S	D	L	P	C	A	T	E	D	A	T	G	S	R	K	T	M	T	W	S	R	Y	G	Q	L	L
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence	S	F	T	D	C	S	G	Y	V	T	R	Y	D	H	D	R	F	G	Q	V	T	A	V	H	R	E	E	G	L	S	Q	Y	R	A	Y	D	S	R	G	Q	L	I	A	V	K	D	T	Q	G	H	E	T	R	Y	E	Y	N	A	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence	D	L	T	T	V	I	A	P	D	G	S	R	N	G	T	Q	Y	D	A	W	G	K	A	I	C	T	T	Q	G	G	L	T	R	S	M	E	Y	D	A	A	G	R	V	I	R	L	T	S	E	N	G	S	H	T	T	F	R	Y	D	V
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720
Sequence	L	D	R	L	I	Q	E	T	G	F	D	G	R	T	Q	R	Y	H	H	D	L	T	G	K	L	I	R	S	E	D	E	G	L	V	T	H	W	H	Y	D	E	A	D	R	L	T	H	R	T	V	N	G	E	T	A	E	R	W	Q	Y
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780
Sequence	D	E	R	G	W	L	T	D	I	S	H	I	S	E	G	H	R	V	T	V	H	Y	G	Y	D	S	K	G	R	L	A	S	E	H	L	T	V	H	H	P	Q	T	N	E	L	L	W	Q	H	E	T	R	H	A	Y	N	A	Q	G	L
Secondary structure
SS confidence
Disorder																																				?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	A	N	R	C	I	P	D	S	L	P	A	V	E	W	L	T	Y	G	S	G	W	L	S	G	M	K	L	G	D	T	P	L	V	E	Y	T	R	D	R	L	H	R	E	T	L	R	S	F	G	R	Y	E	L	T	T	A	Y	T	P	A
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900
Sequence	G	Q	L	Q	S	Q	H	L	N	S	L	L	S	D	R	D	Y	T	W	N	D	N	G	E	L	I	R	I	S	S	P	R	Q	T	R	S	Y	S	Y	S	T	T	G	R	L	T	G	V	H	T	T	A	A	N	L	D	I	R	I	P
Secondary structure
SS confidence
Disorder																															?		?																		?
Disorder confidence

	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960
Sequence	Y	T	T	D	P	A	G	N	R	L	P	D	P	E	L	H	P	D	S	A	L	S	M	W	P	D	N	R	I	A	R	D	A	H	Y	L	Y	R	Y	D	R	H	G	R	L	T	E	K	T	D	L	I	P	E	G	V	I	R	T	D
Secondary structure
SS confidence
Disorder												?	?		?																																				?	?	?	?				?
Disorder confidence

	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020
Sequence	D	E	R	T	H	R	Y	H	Y	D	S	Q	H	R	L	V	H	Y	T	R	T	Q	Y	A	E	P	L	V	E	S	R	Y	L	Y	D	P	L	G	R	R	V	A	K	R	V	W	R	R	E	R	D	L	T	G	W	M	S	L	S	R
Secondary structure
SS confidence
Disorder																					?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050	.	.	.	.	.	.	.	.	.	1060	.	.	.	.	.	.	.	.	.	1070	.	.	.	.	.	.	.	.	.	1080
Sequence	K	P	Q	V	T	W	Y	G	W	D	G	D	R	L	T	T	I	Q	N	D	R	T	R	I	Q	T	I	Y	Q	P	G	S	F	T	P	L	I	R	V	E	T	A	T	G	E	L	A	K	T	Q	R	R	S	L	A	D	T	L	Q	Q
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1090	.	.	.	.	.	.	.	.	.	1100	.	.	.	.	.	.	.	.	.	1110	.	.	.	.	.	.	.	.	.	1120	.	.	.	.	.	.	.	.	.	1130	.	.	.	.	.	.	.	.	.	1140
Sequence	S	G	G	E	D	G	G	S	V	V	F	P	P	V	L	V	Q	M	L	D	R	L	E	S	E	I	L	A	D	R	V	S	E	E	S	R	R	W	L	A	S	C	G	L	T	V	A	Q	M	Q	S	Q	M	D	P	V	Y	T	P	A
Secondary structure
SS confidence
Disorder																																																		?	?	?	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1150	.	.	.	.	.	.	.	.	.	1160	.	.	.	.	.	.	.	.	.	1170	.	.	.	.	.	.	.	.	.	1180	.	.	.	.	.	.	.	.	.	1190	.	.	.	.	.	.	.	.	.	1200
Sequence	R	K	I	H	L	Y	H	C	D	H	R	G	L	P	L	A	L	I	S	T	E	G	T	T	A	W	Y	A	E	Y	D	E	W	G	N	L	L	N	E	E	N	P	H	Q	L	Q	Q	L	I	R	L	P	G	Q	Q	Y	D	E	E	S
Secondary structure
SS confidence
Disorder																																							?		?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1210	.	.	.	.	.	.	.	.	.	1220	.	.	.	.	.	.	.	.	.	1230	.	.	.	.	.	.	.	.	.	1240	.	.	.	.	.	.	.	.	.	1250	.	.	.	.	.	.	.	.	.	1260
Sequence	G	L	Y	Y	N	R	H	R	Y	Y	D	P	L	Q	G	R	Y	I	T	Q	D	P	I	G	L	K	G	G	W	N	F	Y	Q	Y	P	L	N	P	I	S	N	I	D	P	L	G	L	E	T	L	K	C	I	K	P	L	H	S	M	G
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	1270	.	.	.	.	.	.	.	.	.	1280	.	.	.	.	.	.	.	.	.	1290	.	.	.	.	.	.	.	.	.	1300	.	.	.	.	.	.	.	.	.	1310	.	.	.	.	.	.	.	.	.	1320
Sequence	G	T	G	E	R	S	G	P	D	I	W	G	N	P	F	Y	H	Q	Y	L	C	V	P	D	G	K	G	D	Y	T	C	G	G	Q	D	Q	R	G	E	S	K	G	D	G	L	W	G	P	G	K	A	S	N	D	T	K	E	A	A	G
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?			?	?		?			?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1330	.	.	.	.	.	.	.	.	.	1340	.	.	.	.	.	.	.	.	.	1350	.	.	.	.	.	.	.	.	.	1360	.	.	.	.	.	.	.	.	.	1370	.	.	.	.	.	.	.	.	.	1380
Sequence	R	C	D	L	V	E	T	D	N	S	C	V	E	N	C	L	K	G	K	F	K	E	V	R	P	R	Y	S	V	L	P	D	I	F	T	P	I	N	L	G	L	F	K	N	C	Q	D	W	S	N	D	S	L	E	T	C	K	M	K	C
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?		?	?			?		?			?	?	?	?						?	?	?	?	?	?	?	?	?	?	?															?
Disorder confidence

	.	.	.	.	.	.	.	.	.	1390	.	.	.	.	.	.	.
Sequence	S	G	N	N	I	G	R	F	I	R	F	V	F	T	G	V	M
Secondary structure
SS confidence
Disorder	?	?	?										?	?	?	?	?
Disorder confidence