Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	L	F	A	Q	L	S	W	Y	F	R	R	E	W	R	R	Y	L	G	A	V	A	L	L	V	I	I	A	M	L	Q	L	V	P	P	K	V	V	G	I	V	V	D	G	V	T	E	Q	H	F	T	T	G	Q	I	L	M	W	I
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	T	M	V	L	I	A	V	V	V	Y	L	L	R	Y	V	W	R	V	L	L	F	G	A	S	Y	Q	L	A	V	E	L	R	E	D	Y	Y	R	Q	L	S	R	Q	H	P	E	F	Y	L	R	H	R	T	G	D	L	M	A	R	A
Secondary structure
SS confidence
Disorder																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	N	D	V	D	R	V	V	F	A	A	G	E	G	V	L	T	L	V	D	S	L	V	M	G	C	A	V	L	I	M	M	S	T	Q	I	S	W	Q	L	T	L	F	S	L	L	P	M	P	V	M	A	I	M	I	K	R	N	G	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	H	E	R	F	K	L	A	Q	A	A	F	S	S	L	N	D	R	T	Q	E	S	L	T	S	I	R	M	I	K	A	F	G	L	E	D	R	Q	S	A	L	F	A	A	D	A	E	D	T	G	K	K	N	M	R	V	A	R	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	A	R	F	D	P	T	I	Y	I	A	I	G	M	A	N	L	L	A	I	G	G	G	S	W	M	V	V	Q	G	S	L	T	L	G	Q	L	T	S	F	M	M	Y	L	G	L	M	I	W	P	M	L	A	L	A	W	M	F	N	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	E	R	G	S	A	A	Y	S	R	I	R	A	M	L	A	E	A	P	V	V	N	D	G	S	E	P	V	P	E	G	R	G	E	L	D	V	N	I	H	Q	F	T	Y	P	Q	T	D	H	P	A	L	E	N	V	N	F	A	L	K
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?				?	?	?											?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	G	Q	M	L	G	I	C	G	P	T	G	S	G	K	S	T	L	L	S	L	I	Q	R	H	F	D	V	S	E	G	D	I	R	F	H	D	I	P	L	T	K	L	Q	L	D	S	W	R	S	R	L	A	V	V	S	Q	T	P	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	F	S	D	T	V	A	N	N	I	A	L	G	C	P	N	A	T	Q	Q	E	I	E	H	V	A	R	L	A	S	V	H	D	D	I	L	R	L	P	Q	G	Y	D	T	E	V	G	E	R	G	V	M	L	S	G	G	Q	K	Q	R
Secondary structure
SS confidence
Disorder																																																				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		I	S	I	A	R	A	L	L	V	N	A	E	I	L	I	L	D	D	A	L	S	A	V	D	G	R	T	E	H	Q	I	L	H	N	L	R	Q	W	G	Q	G	R	T	V	I	I	S	A	H	R	L	S	A	L	T	E	A	S	E	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590
Sequence		I	V	M	Q	H	G	H	I	A	Q	R	G	N	H	D	V	L	A	Q	Q	S	G	W	Y	R	D	M	Y	R	Y	Q	Q	L	E	A	A	L	D	D	A	P	E	N	R	E	E	A	V	D	A
Secondary structure
SS confidence
Disorder															?						?												?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2hyd chain B Region: 3 - 573 Aligned: 570 Modelled: 571 Confidence: 100.0% Identity: 30% PDB header:transport protein Chain: B: PDB Molecule:abc transporter homolog; PDBTitle: multidrug abc transporter sav1866 Phyre2 PDB 2yl4 chain A Region: 1 - 556 Aligned: 555 Modelled: 556 Confidence: 100.0% Identity: 28% PDB header:membrane protein Chain: A: PDB Molecule:atp-binding cassette sub-family b member 10, PDBTitle: structure of the human mitochondrial abc transporter, abcb10 Phyre2 PDB 3b5w chain E Region: 2 - 572 Aligned: 569 Modelled: 571 Confidence: 100.0% Identity: 28% PDB header:membrane protein Chain: E: PDB Molecule:lipid a export atp-binding/permease protein msba; PDBTitle: crystal structure of eschericia coli msba Phyre2 PDB 3g5u chain B Region: 4 - 587 Aligned: 583 Modelled: 583 Confidence: 100.0% Identity: 25% PDB header:membrane protein Chain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding Phyre2 PDB 3b5x chain B Region: 2 - 571 Aligned: 568 Modelled: 570 Confidence: 100.0% Identity: 28% PDB header:membrane protein Chain: B: PDB Molecule:lipid a export atp-binding/permease protein msba; PDBTitle: crystal structure of msba from vibrio cholerae Phyre2 PDB 3nha chain A Region: 297 - 572 Aligned: 274 Modelled: 276 Confidence: 100.0% Identity: 39% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family b member 6, mitochondrial; PDBTitle: nucleotide binding domain of human abcb6 (adp mg bound structure) Phyre2 PDB 2pmk chain A domain 1 Region: 334 - 572 Aligned: 239 Modelled: 239 Confidence: 100.0% Identity: 40% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 PDB 3b60 chain A domain 1 Region: 322 - 571 Aligned: 250 Modelled: 250 Confidence: 100.0% Identity: 43% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 PDB 2hyd chain A domain 1 Region: 320 - 573 Aligned: 254 Modelled: 254 Confidence: 100.0% Identity: 43% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 PDB 1jj7 chain A Region: 324 - 570 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 34% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 PDB 1mv5 chain A Region: 335 - 571 Aligned: 236 Modelled: 237 Confidence: 100.0% Identity: 33% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 PDB 2cbz chain A Region: 333 - 572 Aligned: 226 Modelled: 227 Confidence: 100.0% Identity: 34% PDB header:transport Chain: A: PDB Molecule:multidrug resistance-associated protein 1; PDBTitle: structure of the human multidrug resistance protein 12 nucleotide binding domain 1 Phyre2 PDB 2iw3 chain B Region: 12 - 590 Aligned: 533 Modelled: 553 Confidence: 100.0% Identity: 14% PDB header:translation Chain: B: PDB Molecule:elongation factor 3a; PDBTitle: elongation factor 3 in complex with adp Phyre2 PDB 2r6f chain A Region: 316 - 585 Aligned: 264 Modelled: 266 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:excinuclease abc subunit a; PDBTitle: crystal structure of bacillus stearothermophilus uvra Phyre2 PDB 2ghi chain D Region: 328 - 571 Aligned: 224 Modelled: 244 Confidence: 100.0% Identity: 36% PDB header:transport protein Chain: D: PDB Molecule:transport protein; PDBTitle: crystal structure of plasmodium yoelii multidrug resistance2 protein 2 Phyre2 PDB 1pf4 chain A domain 1 Region: 314 - 556 Aligned: 243 Modelled: 243 Confidence: 100.0% Identity: 40% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 PDB 2pzf chain B Region: 331 - 559 Aligned: 214 Modelled: 216 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:cystic fibrosis transmembrane conductance regulator; PDBTitle: minimal human cftr first nucleotide binding domain as a head-to-tail2 dimer with delta f508 Phyre2 PDB 3gd7 chain C Region: 329 - 560 Aligned: 229 Modelled: 232 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: C: PDB Molecule:fusion complex of cystic fibrosis transmembrane PDBTitle: crystal structure of human nbd2 complexed with n6-2 phenylethyl-atp (p-atp) Phyre2 PDB 2olk chain D Region: 335 - 570 Aligned: 230 Modelled: 234 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: D: PDB Molecule:amino acid abc transporter; PDBTitle: abc protein artp in complex with adp-beta-s Phyre2 PDB 1xmi chain A Region: 331 - 584 Aligned: 240 Modelled: 241 Confidence: 100.0% Identity: 25% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: ABC transporter ATPase domain-like Phyre2 1 c2hydB_ 2 c2yl4A_ 3 c3b5wE_ 4 c3g5uB_ 5 c3b5xB_ 6 c3nhaA_ 7 d2pmka1 8 d3b60a1 9 d2hyda1 10 d1jj7a_ 11 d1mv5a_ 12 c2cbzA_ 13 c2iw3B_ 14 c2r6fA_ 15 c2ghiD_ 16 d1pf4a1 17 c2pzfB_ 18 c3gd7C_ 19 c2olkD_ 20 d1xmia_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499