BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (258 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hi... 328 1e-88 UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hi... 230 4e-59 UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hi... 227 4e-58 UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hi... 226 8e-58 UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hi... 223 5e-57 UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hi... 218 2e-55 UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hi... 216 6e-55 UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hi... 212 8e-54 UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hi... 211 2e-53 UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hi... 211 2e-53 UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hi... 207 2e-52 UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hi... 206 4e-52 UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hi... 203 4e-51 UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hi... 203 6e-51 UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hi... 197 2e-49 UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, c... 197 4e-49 UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillon... 195 1e-48 UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase su... 194 2e-48 UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hi... 194 3e-48 UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hi... 193 4e-48 UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hi... 193 4e-48 UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hi... 191 2e-47 UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hi... 189 9e-47 UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hi... 188 1e-46 UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hi... 186 9e-46 UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase s... 181 3e-44 UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hi... 180 4e-44 UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococ... 176 8e-43 UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanae... 174 3e-42 UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hi... 173 4e-42 UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hi... 173 4e-42 UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase su... 171 2e-41 UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hah... 171 3e-41 UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase su... 164 2e-39 UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picr... 163 5e-39 UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfati... 162 1e-38 UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase s... 160 4e-38 UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase s... 160 4e-38 UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase s... 160 5e-38 UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter... 157 3e-37 UniRef50_P72139 Putative imidazole glycerol phosphate synthase s... 156 6e-37 UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winog... 154 2e-36 UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Pro... 154 3e-36 UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase su... 153 6e-36 UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria ... 149 1e-34 UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase s... 146 8e-34 UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobact... 144 2e-33 UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit Hi... 144 3e-33 UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Pro... 139 1e-31 UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovi... 137 4e-31 UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis... 137 5e-31 UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hi... 135 1e-30 UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovi... 135 1e-30 UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase su... 135 1e-30 UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter... 134 3e-30 UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C... 133 6e-30 UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_Y... 133 7e-30 UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Pr... 132 1e-29 UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n... 130 4e-29 UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine... 130 4e-29 UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase s... 129 1e-28 UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii H... 127 5e-28 UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogen... 124 3e-27 UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes:... 121 2e-26 UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID... 121 2e-26 UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase Hi... 120 3e-26 UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms Re... 118 1e-25 UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacte... 113 5e-24 UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 T... 110 4e-23 UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase su... 108 2e-22 UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=La... 106 9e-22 UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malasse... 105 1e-21 UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlo... 103 5e-21 UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 103 6e-21 UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. ... 101 2e-20 UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlo... 101 2e-20 UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr... 100 5e-20 UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hi... 100 9e-20 UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 99 2e-19 UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanoco... 97 6e-19 UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxa... 96 1e-18 UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 96 2e-18 UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit H... 94 3e-18 UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 92 2e-17 UniRef50_Q1NTJ9 Histidine biosynthesis n=1 Tax=delta proteobacte... 92 2e-17 UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxa... 92 2e-17 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 91 3e-17 UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 90 8e-17 UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 89 1e-16 UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 88 3e-16 UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 87 4e-16 UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 87 6e-16 UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 86 8e-16 UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlo... 85 2e-15 UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase s... 85 2e-15 UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 85 3e-15 UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 85 3e-15 UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 85 3e-15 UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 84 3e-15 UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 84 4e-15 UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 84 4e-15 UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 84 6e-15 UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 83 7e-15 UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 82 2e-14 UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 82 2e-14 UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 82 2e-14 UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 81 3e-14 UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 81 3e-14 UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole ... 80 6e-14 UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlo... 80 8e-14 UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 80 9e-14 UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 80 1e-13 UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 79 2e-13 UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 79 2e-13 UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 79 2e-13 UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 77 5e-13 UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 77 7e-13 UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 76 1e-12 UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 75 2e-12 UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 75 2e-12 UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 75 2e-12 UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 75 3e-12 UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole... 75 3e-12 UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 74 4e-12 UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 74 5e-12 UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 74 6e-12 UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 74 6e-12 UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 72 1e-11 UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 72 2e-11 UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 5e-11 UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 6e-11 UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 7e-11 UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 8e-11 UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 8e-11 UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 1e-10 UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 70 1e-10 UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 69 1e-10 UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 69 2e-10 UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 68 3e-10 UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 68 4e-10 UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 67 5e-10 UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 67 5e-10 UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 66 9e-10 UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 66 1e-09 UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3... 66 1e-09 UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 65 2e-09 UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 65 2e-09 UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 65 3e-09 UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 4e-09 UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 6e-09 UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 6e-09 UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 7e-09 UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 7e-09 UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 62 2e-08 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 62 2e-08 UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 62 2e-08 UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 62 2e-08 UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 62 3e-08 UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 61 3e-08 UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 61 4e-08 UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 61 4e-08 UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanoco... 61 5e-08 UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 60 7e-08 UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 60 7e-08 UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 60 7e-08 UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomyc... 60 8e-08 UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 60 9e-08 UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=... 59 1e-07 UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 59 1e-07 UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 59 1e-07 UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi... 59 2e-07 UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 59 2e-07 UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collins... 59 2e-07 UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 59 2e-07 UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 59 2e-07 UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 58 3e-07 UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 57 5e-07 UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 57 5e-07 UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 56 1e-06 UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 55 2e-06 UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 55 2e-06 UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 55 2e-06 UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 54 5e-06 UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 54 6e-06 UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 53 8e-06 UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 1e-05 UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 1e-05 UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 1e-05 UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxa... 52 1e-05 UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 1e-05 UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 1e-05 UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 2e-05 UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 2e-05 UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 2e-05 UniRef50_Q9F8I8 Cyclase (Fragment) n=1 Tax=Carboxydothermus hydr... 52 2e-05 UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 52 3e-05 UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 51 3e-05 UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 51 3e-05 UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxa... 51 3e-05 UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 50 6e-05 UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 50 7e-05 UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 50 8e-05 UniRef50_C6MNJ9 NADH:flavin oxidoreductase/NADH oxidase n=1 Tax=... 50 9e-05 UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazol... 48 3e-04 UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 48 4e-04 UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxa... 47 4e-04 UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxa... 47 6e-04 UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirg... 47 9e-04 UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxa... 46 0.001 UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 46 0.001 UniRef50_B8FH09 Dihydrouridine synthase DuS n=1 Tax=Desulfatibac... 46 0.001 UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 46 0.001 UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 45 0.002 UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxa... 45 0.002 UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 44 0.004 UniRef50_Q1ZGI3 NifR3/Smm1 family protein n=1 Tax=Psychromonas s... 44 0.005 UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 43 0.010 UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 42 0.017 UniRef50_B2V631 Thiamine-phosphate pyrophosphorylase n=3 Tax=Sul... 41 0.033 UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 41 0.040 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 41 0.043 UniRef50_Q036K5 Dioxygenase n=19 Tax=Bacteria RepID=Q036K5_LACC3 40 0.065 UniRef50_Q2RIV8 5-methyltetrahydrofolate--homocysteine S-methylt... 40 0.079 UniRef50_A2EN54 Putative uncharacterized protein n=1 Tax=Trichom... 40 0.085 UniRef50_A2ST44 Histidine biosynthesis protein n=1 Tax=Methanoco... 40 0.092 UniRef50_C8VZK1 NADH:flavin oxidoreductase/NADH oxidase n=1 Tax=... 40 0.097 >UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hisF n=360 Tax=Bacteria RepID=HIS6_XANOM Length = 258 Score = 328 bits (841), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 163/256 (63%), Positives = 197/256 (76%), Gaps = 1/256 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML++RIIPCLDVR+G+VVKGV+F +H +GDIV LA RY +GADELVFYDI AS +GR Sbjct: 1 MLSRRIIPCLDVRNGRVVKGVKFHDHIDMGDIVELALRYRAQGADELVFYDIGASPEGRS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VD +WV RVA +IDIPFCVAGGI +E A +L GADKISINSPAL P LI+ LAD F Sbjct: 61 VDYTWVERVARLIDIPFCVAGGIGDVETARAVLHAGADKISINSPALGRPQLISELADAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 GVQC+VVGID+ + + G++ V +YTGD S+T+ TLDWV E Q+ GAGEIVLN M+ Sbjct: 121 GVQCVVVGIDSIRE-DDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMD 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGVR GYD+ QL++VR +CHVPLIASGGAG M+HF + F ADVDGALAASVFH I Sbjct: 180 NDGVRRGYDIAQLRQVRALCHVPLIASGGAGEMQHFADVFDQADVDGALAASVFHSGAIP 239 Query: 241 IGELKAYLATQGVEIR 256 I ELK +L Q +E+R Sbjct: 240 IPELKQFLRAQQIEVR 255 >UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hisF n=10 Tax=Bacteria RepID=HIS6_SULSY Length = 252 Score = 230 bits (586), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 126/257 (49%), Positives = 166/257 (64%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV G+VVKGV F N GD V +A Y +EGADELVF DITASS+ R Sbjct: 1 MLAKRIIPCLDVDKGRVVKGVNFVNLIDAGDPVEIASVYDKEGADELVFLDITASSEDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V + AE + +P V GG++SLED K+L GADK+SIN+ A+ +P+L+ A RF Sbjct: 61 IILDVVKKTAETVFMPLTVGGGVRSLEDIRKLLENGADKVSINTAAVKNPSLVENAAIRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVV ID E K+ V + G RT T + ++W + V+ GAGEI+L M+ Sbjct: 121 GSSTIVVAIDAKKVGEN-KWEVYIHGG---RTP-TGIDAIEWAKAVESLGAGEILLTSMD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG ++GYD+E K V E +P+IASGGAG ++HF EAF D LAAS+FH + I Sbjct: 176 KDGTKSGYDIELTKAVSEAVKIPVIASGGAGNVQHFYEAFEYGKADACLAASLFHFKEIE 235 Query: 241 IGELKAYLATQGVEIRI 257 I ELK YL +G+ +R+ Sbjct: 236 ISELKNYLKNKGINVRL 252 >UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hisF n=28 Tax=Bacteria RepID=HIS6_EXISA Length = 255 Score = 227 bits (578), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 121/256 (47%), Positives = 166/256 (64%), Gaps = 8/256 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML +RIIPCLDV++G+VVKG++F IGD V +AK Y E GADELVF DITAS++ R Sbjct: 1 MLKRRIIPCLDVKEGRVVKGIEFVQLRDIGDPVEIAKYYDESGADELVFLDITASTERRQ 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VS VA + IP V GGI+SLED + +L GADK+S+N+ A+ P+LI ADRF Sbjct: 61 TMLDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID + + G+Y+V Y G + T ++W ++V GAGE+++ MN Sbjct: 121 GSQCIVVAIDVKF--KDGEYYVYTYGGKQK----TDLLAVEWAKQVAALGAGELLVTSMN 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 QDG ++GYDL L+++REV +P+IASGGAG EH +EA VD AL AS+ H + Sbjct: 175 QDGKQSGYDLSILEQLREVVDIPIIASGGAGNAEHVVEALE--KVDAALLASILHDRKTT 232 Query: 241 IGELKAYLATQGVEIR 256 + E+K + + +R Sbjct: 233 VEEVKHVCKSHNLPMR 248 >UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hisF n=7 Tax=cellular organisms RepID=HIS6_THEP1 Length = 254 Score = 226 bits (575), Expect = 8e-58, Method: Compositional matrix adjust. Identities = 132/257 (51%), Positives = 170/257 (66%), Gaps = 7/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRII CLDV+DG+VVKG F N GD V L K Y+E G DELVF DITAS + R Sbjct: 1 MLAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFLDITASVEKRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V +VAE IDIPF V GGI E A++++ GADK+SIN+ A+ DP+LIT++A F Sbjct: 61 TMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVEDPSLITKIARTF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV ID G++ V Y+G ++ T DWV EV++RGAGEI+L ++ Sbjct: 121 GSQAVVVAIDA--KKVDGEFVVFTYSGKKN----TGILLRDWVVEVERRGAGEILLTSID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + GYD E ++ VR + +P+IASGGAG MEHFLEAF ALAASVFH + I+ Sbjct: 175 RDGTKAGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLAGADA-ALAASVFHFREID 233 Query: 241 IGELKAYLATQGVEIRI 257 + ELK YL GV +R+ Sbjct: 234 VRELKEYLKKHGVNVRL 250 >UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hisF n=157 Tax=root RepID=HIS6_HELMI Length = 261 Score = 223 bits (568), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 125/261 (47%), Positives = 164/261 (62%), Gaps = 9/261 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV G+VVKG F N GD V LA Y +EGADE+VF DITASSDGR Sbjct: 1 MLAKRIIPCLDVHGGRVVKGTNFVNLRDAGDPVELAAVYDKEGADEVVFLDITASSDGRA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R AE + IPF V GG++S+ED ++L GADKIS+N+ A+ P LI+ A +F Sbjct: 61 IMLDVVRRTAEEVFIPFTVGGGLRSVEDIREMLKAGADKISLNTSAVQTPKLISDGAWKF 120 Query: 121 GVQCIVVGIDT--WYDAETGK---YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIV 175 G QCIVV ID DAE + V + G + T + L+W + V++ GAGEI+ Sbjct: 121 GSQCIVVAIDARRRRDAEGNPVEGWEVYTHGG----RKPTGIDVLEWARRVEELGAGEIL 176 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 L M++DG ++GYD+ + V E +P+IASGG G ++H +E D ALAAS+FH Sbjct: 177 LTSMDKDGTKDGYDIPLTRAVSEAVTIPVIASGGVGNLDHIVEGLTVGKADAALAASIFH 236 Query: 236 KQIINIGELKAYLATQGVEIR 256 + IGE K YL +GV +R Sbjct: 237 YREYTIGETKEYLRERGVHVR 257 >UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hisF n=224 Tax=Bacteria RepID=HIS6_STACT Length = 254 Score = 218 bits (555), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 107/256 (41%), Positives = 161/256 (62%), Gaps = 4/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ KRIIPCLDV+DG+VVKGVQF+ IGD V LA Y E ADELVF DI+ + +G Sbjct: 1 MIKKRIIPCLDVKDGRVVKGVQFKGLRDIGDPVALAAYYNAELADELVFLDISRTENGHQ 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + A + IP + GGI S +D + +L GADK+S+NS AL +P+L+ +++F Sbjct: 61 MMLDIIEETASKLFIPLTIGGGISSTDDISTLLKHGADKVSLNSSALRNPSLVKEASEKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI + +D ++ E + + G + T LDWV++V+ GAGE+++ M+ Sbjct: 121 GSQCICIAVDAKWEDERNDWFCYTHGGKQP----TDIRVLDWVRQVEYLGAGELLVTSMD 176 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV+ G+D + L ++ V +P+IASGG G +HF++ F+ +V LAAS+FH + Sbjct: 177 YDGVKQGFDHQLLNQINTVVSIPVIASGGGGNAQHFVDLFQQTNVSAGLAASIFHDKETT 236 Query: 241 IGELKAYLATQGVEIR 256 IG +K YL +GV++R Sbjct: 237 IGAVKTYLKDKGVDVR 252 >UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hisF n=3 Tax=Bacteria RepID=C8PKX5_9PROT Length = 306 Score = 216 bits (550), Expect = 6e-55, Method: Compositional matrix adjust. Identities = 130/305 (42%), Positives = 172/305 (56%), Gaps = 51/305 (16%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 AKRIIPCLDV+DG+VVKGV F GD V +AKRY EEGADEL F DITAS GR Sbjct: 4 FAKRIIPCLDVKDGRVVKGVNFVGLVDAGDPVEIAKRYNEEGADELCFLDITASHLGRDT 63 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V RVA + IP V GGI++++D +++L+ G DKIS+NS A+ +P LI A++FG Sbjct: 64 IVDVVERVARELFIPLTVGGGIRTIDDISRLLNVGCDKISLNSAAIKNPNLIDEAANKFG 123 Query: 122 VQCIVVGID-------------------TWYDAETGKYHVNQYTGDESRT---------- 152 QC+V+ ID + D G + + G E+R Sbjct: 124 SQCVVIAIDAKRNSIEISRGDLYGEARNSNGDLHGGMRNPDTNLGSEARNFGEILRGAQD 183 Query: 153 -------------------RV-TQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQ 192 R+ T + L W +E Q+RGAGEI+L M+ DGV+NG++L Sbjct: 184 EILTGNGELCGYSVFINGGRLDTGRDALAWAKEAQERGAGEILLTSMDCDGVKNGFEL-N 242 Query: 193 LKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQG 252 L ++ +P+IASGGAG MEHF +AF A D LAAS+FH + I I LKAYL QG Sbjct: 243 LTRIFSALDIPVIASGGAGKMEHFKDAFL-AGADACLAASIFHFREIEIKALKAYLQEQG 301 Query: 253 VEIRI 257 +E+R+ Sbjct: 302 IEVRL 306 >UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW6_9FIRM Length = 252 Score = 212 bits (540), Expect = 8e-54, Method: Compositional matrix adjust. Identities = 116/257 (45%), Positives = 158/257 (61%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M KRIIPCLDV+DG+VVKG F GD V LA RY EE ADELVF DITASSD R Sbjct: 1 MYTKRIIPCLDVKDGRVVKGTNFVGLRDAGDPVELAARYDEERADELVFLDITASSDNRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + A + IPF V GGI+++ED ++L GADK S+N+ A+ +P L+ A++F Sbjct: 61 TMVNVARDCASKVFIPFTVGGGIRTVEDMRRMLKAGADKTSLNTAAVKNPGLLKEGAEKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ +D G + Y + RT T + L+WV++ GAGEI+L M+ Sbjct: 121 GRQCMVLAVDA---RRAGNHRWEVYV-NGGRT-PTGLDCLEWVKKAVALGAGEILLTSMD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG ++GYD+E + V + +VP+IASGGAG +EHF + D LAASVFH Sbjct: 176 ADGTKDGYDIELTRAVSDAVNVPVIASGGAGKLEHFYDVLTLGHADAVLAASVFHYGQFT 235 Query: 241 IGELKAYLATQGVEIRI 257 + ++K YL ++GVE+R Sbjct: 236 VRQVKEYLQSRGVEVRF 252 >UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M910_CALMQ Length = 254 Score = 211 bits (538), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 115/256 (44%), Positives = 157/256 (61%), Gaps = 8/256 (3%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L +RIIPC+DV VVKGV F ++GD V LA RY EEGADEL DITA+ GR Sbjct: 7 LVRRIIPCMDVDADIVVKGVNFEGLRVMGDPVELASRYEEEGADELFLLDITATVQGRST 66 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V VA + IP V GGI+ +EDA GADK+SIN+ A+ DP+++ +L+ +G Sbjct: 67 FLETVRNVAAAVSIPLGVGGGIRGMEDADAAFKAGADKVSINTAAVKDPSIVAKLSREYG 126 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q +VV IDT ++ V G R T +DW + V++ GAGE+++ ++ Sbjct: 127 SQSVVVAIDTRRI--NNEWRVFIMGG----RRETLLNAVDWARTVEELGAGELLVTSIDA 180 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG R GYD+E +++ + ++P+IASGGAG HFLE + A D ALAASVFH +INI Sbjct: 181 DGTRAGYDIELYRRLADAVNIPVIASGGAGEPSHFLEVLKYA--DAALAASVFHMGVINI 238 Query: 242 GELKAYLATQGVEIRI 257 LKAYL+ G+ +RI Sbjct: 239 SILKAYLSELGIRVRI 254 >UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=C7P985_METFA Length = 272 Score = 211 bits (537), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 117/277 (42%), Positives = 166/277 (59%), Gaps = 26/277 (9%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIPCLD++DG+VVKG +F N GD V LA+ Y +EGADELVF DITAS++ R Sbjct: 1 MLTKRIIPCLDIKDGRVVKGTKFLNLRDAGDPVELAQLYDDEGADELVFLDITASAEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R AE + IP V GGIKS+ED KIL GADKISIN+ A+ +P LI ++ F Sbjct: 61 IIIDVVERTAEKVFIPLTVGGGIKSIEDFRKILRAGADKISINTAAVKNPNLIKEASEIF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWE--------------------TL 160 G QC+VV ID ++++N+ D+ V + E + Sbjct: 121 GSQCVVVAID------AKRHYINEDEIDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAI 174 Query: 161 DWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 +W ++V++ GAGEI+L +++DG ++GYDL +++ + +P+IASGG G EH EAF Sbjct: 175 EWAKKVEELGAGEILLTSIDKDGTKSGYDLILTREISKSVKLPVIASGGCGKPEHVYEAF 234 Query: 221 RDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D AL A + H + I E+K Y A +G+ +R+ Sbjct: 235 VHGKADAALMAGILHYKEYTIEEIKKYCADRGIPMRL 271 >UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hisF n=19 Tax=cellular organisms RepID=HIS6_DESAA Length = 260 Score = 207 bits (528), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 111/256 (43%), Positives = 157/256 (61%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML+KR+I CLDVRDG+ KG++F+ + IGD V +A+ Y E G DELVFYDITAS + R Sbjct: 1 MLSKRVIVCLDVRDGKTTKGIKFKGNVDIGDPVDMARVYYEAGCDELVFYDITASHEKRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V RVAE I IPF V GGI S+ED +L GA+KIS+NS A+ +P +IT+ A+ F Sbjct: 61 IMIDVVRRVAETIFIPFSVGGGISSVEDMRDVLLAGAEKISVNSAAVKNPKIITQGAEAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+G+D ++ K + L W QE ++ GAGEI LN ++ Sbjct: 121 GNQCVVLGMDVKKVEKSEKIPSGYEIVINGGRTYMGIDALWWAQEGERLGAGEICLNSID 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + GY+LE + E ++P+IASGG G +H + ++ D AL AS+ H Sbjct: 181 ADGTKEGYELELTALISENVNIPVIASGGGGIPQHLGDVLKEGKADAALIASMVHYGTYT 240 Query: 241 IGELKAYLATQGVEIR 256 I E+K +L +QG+ +R Sbjct: 241 IPEIKDHLKSQGISVR 256 >UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=HIS6_THEYD Length = 278 Score = 206 bits (525), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 123/282 (43%), Positives = 170/282 (60%), Gaps = 29/282 (10%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV+DG+VVKGV F N GD V A Y EE ADELVF D+TAS + R Sbjct: 1 MLAKRIIPCLDVKDGRVVKGVNFLNLRDAGDPVENALYYNEEEADELVFLDVTASHEKRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R A V+ +P V GGIKSL+D +L+ GADK+SIN+ A+ DP I + + RF Sbjct: 61 IIIDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRF 120 Query: 121 GVQCIVVGID----------------TWYD---------AETGKYHVNQYTGDESRTRVT 155 G QCIV+ ID +W+D E ++ ++ + G R Sbjct: 121 GSQCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRP--- 177 Query: 156 QWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEH 215 + + W +++++ GAGEI+L M++DG + GYD+E + + E +P+IASGGAGT+EH Sbjct: 178 -IDAIAWAKKMEEFGAGEILLTSMDRDGTKEGYDIELTRAISEAVSIPVIASGGAGTLEH 236 Query: 216 FLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 EAF A D ALAAS+FH + +I E K +L +G+ +RI Sbjct: 237 LYEAFAYAKADAALAASIFHFREYSIREAKEFLRQKGIPVRI 278 >UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hisF n=354 Tax=cellular organisms RepID=HIS6_METBU Length = 273 Score = 203 bits (517), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 118/277 (42%), Positives = 159/277 (57%), Gaps = 24/277 (8%) Query: 1 MLAKRIIPCLDV----RDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 ML KRIIPCLDV G VVKGV+F + + GD V LAKRY E+GADELVF DITAS Sbjct: 1 MLTKRIIPCLDVTLDASGGTVVKGVEFVDLKKAGDPVDLAKRYNEQGADELVFLDITASH 60 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 +GR + R A + IP V GGI S+ED +IL GADK+S+N+ A+ +P I Sbjct: 61 EGRSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREA 120 Query: 117 ADRFGVQCIVVGID-------------TWYDAETGK---YHVNQYTGDESRTRVTQWETL 160 ++ FG QCIV ID T + E G Y V Y G E T +T+ Sbjct: 121 SNIFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIYGGREP----TGLDTV 176 Query: 161 DWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 W ++V++ G+GEI+L MN+DG +G+D+ KK+ E +P+IASGG G EH + F Sbjct: 177 QWAKKVEELGSGEILLTSMNRDGTYDGFDIPITKKLSEELDIPIIASGGVGNPEHMYKGF 236 Query: 221 RDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D D LAAS+FH + ++K L + + +R+ Sbjct: 237 VDGKADAGLAASIFHFGEYTVRDVKEALRAKNIPVRL 273 >UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hisF n=67 Tax=Bacteria RepID=HIS6_SYNY3 Length = 261 Score = 203 bits (516), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 118/257 (45%), Positives = 157/257 (61%), Gaps = 6/257 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LAKRI+PCLDV G+VVKG+ F + + GD V LA+ Y E GADELVF DITA+ + R Sbjct: 3 LAKRILPCLDVNAGRVVKGINFVDLQDAGDPVELARAYNEAGADELVFLDITATHEQRDT 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R AE + IP V GGI +LE +L GADK+S+NS A+ DP I+R +DRFG Sbjct: 63 IIDVVYRTAEEVFIPLTVGGGISTLEHIKNLLRAGADKVSVNSSAVRDPDFISRASDRFG 122 Query: 122 VQCIVVGIDT--WYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 QCIVV ID DA+ + V G E+ T + + W +EV KRGAGE+++ M Sbjct: 123 RQCIVVAIDARRRLDADNPGWDVYVRGGREN----TGLDAIAWAEEVAKRGAGELLVTSM 178 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 + DG + GYDL + E +P+IASGGAG +H EAF + + AL AS+ H + Sbjct: 179 DGDGTQAGYDLALTAAIAERVEIPVIASGGAGNCQHVYEAFTEGKAEAALLASLLHYGQL 238 Query: 240 NIGELKAYLATQGVEIR 256 IGELK +L + + +R Sbjct: 239 TIGELKTFLEARQIPVR 255 >UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKR3_FIBSS Length = 263 Score = 197 bits (502), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 103/256 (40%), Positives = 152/256 (59%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+I CLDVR+ +V KGV+F+ + IGD V + RY++EG DELVFYDITAS++ R Sbjct: 1 MLTKRLIVCLDVRNRKVTKGVKFKGNIDIGDPVEMGARYSDEGVDELVFYDITASAENRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + ++A+ + IPF V GGI++L+D + L GA+K+S+NS A+ P +I A F Sbjct: 61 CDMEMIRQIAKRVFIPFAVGGGIRNLDDMHEALLAGAEKVSVNSLAVLHPEIIAEGAKAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV+G+D + + K + + L W + ++ G GEI LN ++ Sbjct: 121 GRQCIVLGMDAKFVGVSDKIPSGYEVFIRGGRQAMGIDALQWAKRAEELGVGEICLNSID 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV+NGY+L + + VP+IASGGAGT H ++ FR D AL AS+ H Sbjct: 181 TDGVKNGYELTITDMIAKAVQVPVIASGGAGTPAHIVDLFRKTSADAALVASMVHFGDYT 240 Query: 241 IGELKAYLATQGVEIR 256 + +K + G+ +R Sbjct: 241 VPGIKGEMLAAGIPVR 256 >UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW6_HODCD Length = 264 Score = 197 bits (500), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 103/255 (40%), Positives = 151/255 (59%), Gaps = 6/255 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LA RIIPC+DV++G VVKG +F +G+ +A Y+ GADEL F D++ASS R + Sbjct: 5 LALRIIPCMDVKEGHVVKGSKFCGLVRVGEATLVANSYSVSGADELCFLDVSASSANRSI 64 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + +S+VAE IP V GG++ ++D +L GADK+SINS + P I R D+FG Sbjct: 65 LYATISQVAESCLIPLTVGGGVRRVKDVGDLLRAGADKVSINSAGVLSPEFIARCVDKFG 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QC+VV ID A G + V + G R T + L++ + + GAGEI+L +++ Sbjct: 125 SQCVVVSIDC--KASDGAWEVCTHGG----ARPTGVDALEYACQAAQFGAGEILLTSVDR 178 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DGV+ GYDL LK V + VP+IASGG G + HF A + L AS+ H+ + + Sbjct: 179 DGVKAGYDLALLKAVSSLVSVPVIASGGGGELSHFALALIEGGASAVLTASLLHRNELTV 238 Query: 242 GELKAYLATQGVEIR 256 +LK +L + G+ +R Sbjct: 239 SQLKFFLGSCGIVVR 253 >UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC 17748 RepID=C4FS06_9FIRM Length = 256 Score = 195 bits (495), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 104/257 (40%), Positives = 159/257 (61%), Gaps = 3/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCL V +G+V GVQFR+ GD V A+RY +GADELV DITA+++ R Sbjct: 1 MLAKRIIPCLGVANGRVQNGVQFRDMVDAGDPVECAERYEIQGADELVLLDITATTEARK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V ++ + +P V GGI S+ED +++ GADK+SIN+ AL++P+LIT A +F Sbjct: 61 TFTDIVLNASDKVFMPLTVGGGITSVEDMTQLMKAGADKVSINTAALSNPSLITEGAKKF 120 Query: 121 GVQCIVVGIDTWYDA-ETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G Q IVV +D Y+ E Y T ++ + L+W +E RGAGE+++ + Sbjct: 121 GNQGIVVCLDVKYNPFEKMWYAYGHGTSNDPGAQCKN--ALEWAKEAVDRGAGELLVTSI 178 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++ G G+D+E + + EV VP+ A GGAG ++HF++ F +V GALA+++ H +++ Sbjct: 179 DRHGTGLGFDIELYQALAEVVDVPVTAFGGAGNIQHFVDLFTKTNVTGALASALLHNKVL 238 Query: 240 NIGELKAYLATQGVEIR 256 I ++K L G+ +R Sbjct: 239 TIKDIKKALHAAGIVVR 255 >UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H029_9FIRM Length = 250 Score = 194 bits (493), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 104/255 (40%), Positives = 154/255 (60%), Gaps = 6/255 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + K I+PC+D+R G+VVKG++F + + D V LAK Y GAD LVFYDI AS + + + Sbjct: 1 MKKLIMPCMDIRHGKVVKGIKFEGVKDVADPVELAKYYDATGADILVFYDIAASVEDKQI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V V D+P GG+K++ED I+ GAD +SIN+ A+ +P L+ A++ G Sbjct: 61 YEGLFKSVRAVSDLPLVAGGGLKTIEDVDNIIKLGADMVSINTGAIDNPDLLNEAAEKIG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +++ +D G+YHV + G T + L+W+ E RGAG +VLN ++ Sbjct: 121 SENVILSVDA--KKVNGEYHVFRNAG----MMDTGLDALEWISEGYDRGAGILVLNSIDT 174 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DGV+ GYD+E LK EV ++ASGGAG M+ F EA V+ ALAASVFH + I I Sbjct: 175 DGVKAGYDIEMLKAAGEVTDAKIVASGGAGKMQDFKEALMLPKVEVALAASVFHYKEIVI 234 Query: 242 GELKAYLATQGVEIR 256 +LK YL +G+++ Sbjct: 235 DDLKEYLRKEGIDVN 249 >UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI6_KANKD Length = 265 Score = 194 bits (493), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 105/260 (40%), Positives = 156/260 (60%), Gaps = 8/260 (3%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L R+I CLDV G+VVKGV F+ + +GD V LA RY E+GADE++F DI A+ + R Sbjct: 5 LKSRVIVCLDVAHGRVVKGVNFKGLQDMGDPVELAIRYQEQGADEIIFLDIKATLEQRAN 64 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+RVAE + IPF V GG+ + D A+ L+ GADK+++NS A+ P L+ +A FG Sbjct: 65 ALEVVTRVAENLSIPFTVGGGLNTYADVAQFLNAGADKVALNSAAVKHPDLVDEIAKGFG 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQY----TGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 QC+VV +D + + ++Y G + +T + W+ E+++RGAGEI+L Sbjct: 125 SQCVVVAVDLNQEQDQKTQGSSEYEVYINGGHT---LTDLNAMQWLTEIEQRGAGEILLT 181 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 M++DG G+D E + +V + + +IASGGA HF + F A D ALAA +FH+ Sbjct: 182 AMHRDGTGFGFDNELMSQVSKKLGIQVIASGGASKPAHFTDTFL-AGSDAALAAGMFHRG 240 Query: 238 IINIGELKAYLATQGVEIRI 257 +G++K L GV +RI Sbjct: 241 EFTVGQVKQELLNNGVAVRI 260 >UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hisF n=55 Tax=cellular organisms RepID=HIS6_THEEB Length = 281 Score = 193 bits (491), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 114/260 (43%), Positives = 155/260 (59%), Gaps = 8/260 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRI+PCLDV+ G+VVKGV F N GD V LA+ Y GADELVF DITA+ + R Sbjct: 2 MLAKRILPCLDVKAGRVVKGVNFVNLRDAGDPVELAQAYNAAGADELVFLDITATHEERN 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R A+ + IP V GGI+SL +L GADK+S+NS A+ P L+ + +DRF Sbjct: 62 ILIDVVYRTADQVFIPLTVGGGIQSLTMIKDLLRAGADKVSLNSAAVRQPDLVNQASDRF 121 Query: 121 GVQCIVVGIDTWYDAETG----KYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 G QCIVV ID + + ++ V G E+ T + + W E+ KRGAGE+++ Sbjct: 122 GAQCIVVAIDARREPDCAPDQPRWQVYVRGGREA----TGLDAVAWAVEMAKRGAGELLV 177 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 M+ DG + GYDLE + + E +P+IASGGAGT EH A + + AL AS+ H Sbjct: 178 TSMDADGTQAGYDLELTRAIAERVEIPVIASGGAGTCEHIRAALVEGKAEAALLASLLHY 237 Query: 237 QIINIGELKAYLATQGVEIR 256 + I ++K YL V +R Sbjct: 238 GQLTIAQIKGYLHQHQVPVR 257 >UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hisF n=27 Tax=cellular organisms RepID=HIS6_META3 Length = 275 Score = 193 bits (491), Expect = 4e-48, Method: Compositional matrix adjust. Identities = 106/275 (38%), Positives = 157/275 (57%), Gaps = 18/275 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIPCLD+++G+VVKG F GD V L+K Y E+GADELVF DI AS + R Sbjct: 1 MLTKRIIPCLDIKNGRVVKGTNFVELRDAGDPVELSKIYNEQGADELVFLDIGASHEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V + A+ + IP V GGI++ +D +IL GADKIS+N+ A+ +P LI + ++ + Sbjct: 61 IIEHLVEKTADQVFIPLTVGGGIRTTDDFRRILRAGADKISVNTAAIHNPDLIKQSSELY 120 Query: 121 GVQCIVVGIDT--------------WYDAETGKYHVNQYTGDE----SRTRVTQWETLDW 162 G QC+VV ID+ D K N+Y E + T + ++W Sbjct: 121 GAQCVVVAIDSKRHYVNEEDLDSKQLEDKNVVKVDKNKYCWFEVFIYGGRKETGIDAIEW 180 Query: 163 VQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRD 222 + ++ GAGEI+L M+ DG ++GYD+E K + +P+IASGG G +H + F Sbjct: 181 AKTAEELGAGEILLTSMDADGTKDGYDIELTKSISTHIKLPVIASGGCGAPQHIHQVFEY 240 Query: 223 ADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D AL AS+ H + +GELK Y + + +R+ Sbjct: 241 GKADAALMASILHYREYTVGELKKYCMDKNIPMRL 275 >UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hisF n=76 Tax=Bacteria RepID=HIS6_MYCBP Length = 267 Score = 191 bits (484), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 115/260 (44%), Positives = 152/260 (58%), Gaps = 10/260 (3%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LA R+IPCLDV DG+VVKGV F N GD V LA Y EGADEL F D+TASS GR Sbjct: 13 LAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTFLDVTASSSGRAT 72 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R AE + IP V GG++++ D +L GADK+++N+ A+A L+ +A +FG Sbjct: 73 MLEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFG 132 Query: 122 VQCIVVGIDTWY----DAET-GKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 QCIV+ +D A T + V + G R T + + W G GEI+L Sbjct: 133 SQCIVLSVDARTVPVGSAPTPSGWEVTTHGG----RRGTGMDAVQWAARGADLGVGEILL 188 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 N M+ DG + G+DL L+ VR VP+IASGGAG +EHF A LAASVFH Sbjct: 189 NSMDADGTKAGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADA-VLAASVFHF 247 Query: 237 QIINIGELKAYLATQGVEIR 256 + + IG++KA LA +G+ +R Sbjct: 248 RELTIGQVKAALAAEGITVR 267 >UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hisF n=420 Tax=cellular organisms RepID=HIS6_BRUMB Length = 261 Score = 189 bits (479), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 110/257 (42%), Positives = 152/257 (59%), Gaps = 3/257 (1%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L R+IPCLDV+DG+VVKGV F + GD V A+ Y GADEL F DITASSD R Sbjct: 3 LKARVIPCLDVKDGRVVKGVNFVDLIDAGDPVEAARAYDAAGADELCFLDITASSDNRET 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+R AE +P V GG++ + D K+L GADK+SIN+ A+ +P + AD+FG Sbjct: 63 IFDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFG 122 Query: 122 VQCIVVGIDTWYDAETGKY-HVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 QCIVV ID + G+ H +T + T + +++ Q+V GAGEI+L M+ Sbjct: 123 NQCIVVAIDAKKVSGAGENDHWEIFT--HGGRQPTGIDAVEFAQKVVDLGAGEILLTSMD 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + GYD+ + V + P+IASGG GT++H + RD LAAS+FH Sbjct: 181 RDGTKAGYDVALTRAVADSVRAPVIASGGVGTLDHLVAGIRDGHATAVLAASIFHFGTYT 240 Query: 241 IGELKAYLATQGVEIRI 257 IGE K Y+A G+ +R+ Sbjct: 241 IGEAKRYMAEAGIPMRL 257 >UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hisF n=36 Tax=cellular organisms RepID=HIS6_HALWD Length = 270 Score = 188 bits (478), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 115/273 (42%), Positives = 148/273 (54%), Gaps = 21/273 (7%) Query: 1 MLAKRIIPCLDV---RDGQ--VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITAS 55 ML KRIIPC+DV DG V G+ F + E GD V +AK+Y GADE VF DITAS Sbjct: 1 MLTKRIIPCIDVDLDEDGNPAVYTGINFEDLEYTGDPVEMAKQYNMAGADEFVFLDITAS 60 Query: 56 SDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + GR VSRVA+ I IP V GGI++ +D L GADK+SIN+ AL P LIT Sbjct: 61 AVGRETMLETVSRVADEIFIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALETPELITT 120 Query: 116 LADRFGVQCIVVGIDT------------WYDAETGKYHVNQYTGDESRTRVTQWETLDWV 163 A FG QCIV+ +D D E+ + G E T + L+WV Sbjct: 121 GASAFGSQCIVISVDARRRFDEQGENYLSVDGESCWFECTVKGGREG----TGIDVLEWV 176 Query: 164 QEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA 223 E + RGAGE+ +N ++ DG ++GYD+ V + P+IAS G G+ E F +A Sbjct: 177 TEAETRGAGELFINSIDADGTQDGYDIPLTSAVCDAVSTPVIASSGCGSPADMHEVFTEA 236 Query: 224 DVDGALAASVFHKQIINIGELKAYLATQGVEIR 256 D LAAS+FH +I K YL +GV IR Sbjct: 237 GADAGLAASIFHFGEYSIEATKEYLDERGVPIR 269 >UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hisF n=14 Tax=Bacteria RepID=HIS6_BEUC1 Length = 256 Score = 186 bits (471), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 102/255 (40%), Positives = 148/255 (58%), Gaps = 1/255 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +A R++PCLDV G+VVKGV F + GD V LA+RY +GADE+ F D++AS+ GR Sbjct: 3 VALRVVPCLDVDGGRVVKGVNFLDLRDAGDPVELARRYDADGADEITFLDVSASTQGRAT 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 VS AE + +P V GG++++ D +L GADK+ +N+ A+A P L+T +A +G Sbjct: 63 TLEMVSATAEQVFVPLTVGGGVRAVADVEALLRAGADKVGVNTAAIARPELLTEIAQHYG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q +V+ +D + T + ++W E RGAGE++LN ++ Sbjct: 123 NQVLVLSVDARRCPDGVVTDSGFEVTTHGGRTGTGIDAVEWAAEATSRGAGEVLLNSIDA 182 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G+D+E ++ VR V PL+ASGGAGT+E F+ A R LAASVFH + I Sbjct: 183 DGTTAGFDVEMIEAVRAVVDTPLVASGGAGTVEDFVAAARAGADA-VLAASVFHYGTLTI 241 Query: 242 GELKAYLATQGVEIR 256 E+KA L G E+R Sbjct: 242 SEVKAALRDAGFEVR 256 >UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase subunit n=3 Tax=Bacteria RepID=Q2LTH2_SYNAS Length = 254 Score = 181 bits (458), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 99/253 (39%), Positives = 148/253 (58%), Gaps = 3/253 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 +I+PCLD+++G+VVKG+ F + GD V A Y EGADEL DI A+ + R Sbjct: 5 KIMPCLDMKEGRVVKGIHFVELKDAGDPVENAAFYQAEGADELAMLDIAATLENRKTRLE 64 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 WV++V+ V+ IP V GGI +LED +L GA KIS+NS A+ +P+L++ A +FG + Sbjct: 65 WVNKVSAVLTIPLTVGGGISTLEDIELVLQAGAAKISMNSAAVKNPSLVSEAAKKFGSEK 124 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 I V ID +++ +G T + + W + Q+ GAG I+ M+ DG Sbjct: 125 ITVAIDARRNSQMPSGFELVVSGG---TLPVARDAVAWARTCQELGAGVILPTSMDGDGT 181 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 R GYD+E K + + +P++ASGGAG +E F EA + LAASVFH + ++I + Sbjct: 182 RAGYDIEYTKAIADAVDLPVVASGGAGKLEDFYEAVQKGGASILLAASVFHYRTLSIRAV 241 Query: 245 KAYLATQGVEIRI 257 K YLA +G+ + I Sbjct: 242 KQYLADRGLPVII 254 >UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Thauera sp. MZ1T RepID=C4ZLR4_THASP Length = 226 Score = 180 bits (457), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 99/257 (38%), Positives = 146/257 (56%), Gaps = 31/257 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV+ G+VVKGV F GD V +A+RY E+ Sbjct: 1 MLAKRIIPCLDVKSGRVVKGVNFVELRDAGDPVEIARRYDEQ------------------ 42 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VAE + IP V GG++ +ED ++L+ GADK+S+N+ A+ +P L+ A + Sbjct: 43 --------VAEQVFIPLTVGGGVRVVEDVRRLLNAGADKVSMNTAAVNNPQLVFEAASKV 94 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID A GK+ V + G + T + ++W ++V+ GAGEI+L M+ Sbjct: 95 GSQCIVVAIDAKQTA-PGKWEVFTHGGRNN----TGLDAIEWARKVESLGAGEILLTSMD 149 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG ++G+DL + V + +P+IASGG GT+EH E + D LAAS+FH Sbjct: 150 RDGTKSGFDLALTRAVSDAVRIPVIASGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHT 209 Query: 241 IGELKAYLATQGVEIRI 257 + E K + +G+E+R+ Sbjct: 210 VREAKELMRARGIEVRL 226 >UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococcoides RepID=A5FQU7_DEHSB Length = 268 Score = 176 bits (445), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 91/257 (35%), Positives = 141/257 (54%), Gaps = 1/257 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M +IIPCLDV+DG+VVK ++F + D A Y+++GADEL F DITA+ + Sbjct: 1 MKPIKIIPCLDVKDGRVVKEIKFTDMADARDPAEAAFVYSKQGADELAFLDITATIENSS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + WV ++ +P GGI++L+D + + G +++N+ + I + RF Sbjct: 61 IHTDWVKKIISKTSLPLIAGGGIRNLQDIENLFTLGVSNVALNTITPQNQEFIRKAVARF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I+V ID + G H T + E +DW ++V+ GAG I+L + Sbjct: 121 GSERIIVAIDGIKNPP-GNGHPRLETVMPNGDDTHNLELVDWAKQVEALGAGAILLTSKD 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG ++G+D+E ++ V +P+IASGGAG +E A + LAASVFH IIN Sbjct: 180 TDGTKDGFDMEMIRSVTRAVSIPVIASGGAGKLEDMYAAIIEGKAQAVLAASVFHSGIIN 239 Query: 241 IGELKAYLATQGVEIRI 257 I ELK YL ++G+ + I Sbjct: 240 ISELKTYLHSKGIPVNI 256 >UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B9F8_THEAS Length = 253 Score = 174 bits (441), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 91/256 (35%), Positives = 158/256 (61%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ KRIIP ++ ++VKG FR+H +GD V A +GA+E+V D+ A+ +GR+ Sbjct: 1 MMPKRIIPQFLLKGSRLVKGTSFRDHVDVGDPVSQAMIQDAQGAEEIVLVDVDATREGRL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VD S +SR+ E +P V GG+ +++DA+++ GADK+ +N+ A+ +P++I LA+RF Sbjct: 61 VDTSLISRMVERCRLPIAVGGGVGNVDDASRLFVAGADKVIVNTAAVLNPSMIRPLAERF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV +D +++ G V + +G+E + + ++ ++ GAGE ++ ++ Sbjct: 121 GAQSVVVSLDLKRNSKRGWVPVVR-SGEEE----VDLDFVYLLEALEANGAGEFIVTSVD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G +G+DL+ LK VREV VPLIASGGAG H +E F D++G + + + Sbjct: 176 REGTLSGFDLDMLKVVREVVKVPLIASGGAGNYLHLVELFLSIDLEGVGIGKMLALRDYD 235 Query: 241 IGELKAYLATQGVEIR 256 + +KA+L +G+ +R Sbjct: 236 VVRIKAFLKGRGIPVR 251 >UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hisF n=24 Tax=cellular organisms RepID=HIS6_HALS3 Length = 273 Score = 173 bits (439), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 116/272 (42%), Positives = 152/272 (55%), Gaps = 22/272 (8%) Query: 2 LAKRIIPCLDVR---DGQ--VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 L KR+IPC+DV DG+ V GV F GD V +AKRY E GADE VF DITAS+ Sbjct: 3 LTKRVIPCIDVDLDDDGEPAVYTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASA 62 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 +GR VS VA+ + IP V GGI+ +D + L GADK+SINS A+ADP+L+ R Sbjct: 63 EGRETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRG 122 Query: 117 ADRFGVQCIVVGID------------TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQ 164 A FG QCIV+ +D T D E+ + + G E T + ++WVQ Sbjct: 123 AKAFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREG----TGMDAIEWVQ 178 Query: 165 EVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD 224 E Q+RGAGE+ +N ++ DG ++GYD+ V + P+IAS G G + DA Sbjct: 179 EAQRRGAGELFVNSIDADGTQDGYDVPLTAAVCDAVSTPVIASSGCGA-PGDMADAYDAG 237 Query: 225 VDGALAASVFHKQIINIGELKAYLATQGVEIR 256 D ALAAS+FH +I E K LA G IR Sbjct: 238 ADAALAASIFHFDEYSIAETKETLADAGYPIR 269 >UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Synechococcus sp. CC9311 RepID=Q0IDQ9_SYNS3 Length = 255 Score = 173 bits (439), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 98/256 (38%), Positives = 147/256 (57%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP LD++ G ++KGVQ +GD + AKRY+E GADEL+F D+ AS R Sbjct: 1 MRNLRIIPRLDIKSGTLIKGVQMEGWRKVGDPILAAKRYSEYGADELLFMDVVASLYERN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V +V + IP V GGI+ ++D +LS GADK+S+N+ AL P LI ++DR+ Sbjct: 61 TLHEIVEQVCSNVFIPVTVGGGIRKIKDVETLLSRGADKVSVNTGALLKPELINEISDRY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q V+ ++ + G+ T D R R + E ++WV+E + RGAGEIVL ++ Sbjct: 121 GSQATVLTVEC---LKCGEKSWEALT-DNGRNRSGR-EVIEWVKEAENRGAGEIVLTSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 QDG G+D++ + V + ++P+IASGG G H +E + DV GA A H + ++ Sbjct: 176 QDGRGYGFDIDLVDIVSQAVNIPIIASGGFGKPSHIVELIKSTDVSGAAIAQALHWEKVS 235 Query: 241 IGELKAYLATQGVEIR 256 E++ L V +R Sbjct: 236 FSEIRDSLRDNNVFLR 251 >UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Bacteria RepID=C5BRY3_TERTT Length = 259 Score = 171 bits (434), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 99/254 (38%), Positives = 143/254 (56%), Gaps = 5/254 (1%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + R I LDV+ Q++K + ++GD AKRY E+GADEL++ D+ AS GR Sbjct: 8 STRFIARLDVKGDQLIKAIHLEGLRVVGDPQIYAKRYYEQGADELLYIDLVASLYGRNKL 67 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 K VSR A+ I IP V GGI+S+ED ++L+ GADK++IN+ A+A+P LI ++A RFG Sbjct: 68 KDIVSRTAQDIFIPLTVGGGIRSVEDVTELLAAGADKVAINTAAVANPALIEQVALRFGS 127 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 QC+V+ I+ E ++ V ES R + + W +E +RGAGEI+L ++Q+ Sbjct: 128 QCMVLSIEAKRLGED-RWEVYTDCARESSGR----DVIAWAKEAVERGAGEILLTSIDQE 182 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G R G+D V E VP+IASGG G EH + A H + I Sbjct: 183 GTRKGFDTALTAAVAETVRVPVIASGGYGQPEHINAITHQGSANAIAFADALHFERETIA 242 Query: 243 ELKAYLATQGVEIR 256 LK+Y A G+ +R Sbjct: 243 SLKSYGAEAGLRVR 256 >UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SCV5_HAHCH Length = 255 Score = 171 bits (432), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 94/259 (36%), Positives = 151/259 (58%), Gaps = 8/259 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIP L + G++VKG QF GD V A+ Y + ADELVF D+ A+ G Sbjct: 1 MLKKRIIPMLLLSQGRMVKGKQFSAFRDTGDPVSAARIYNAQFADELVFLDVDANRQGSD 60 Query: 61 VDK--SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 ++ + + +V+ +P V GG+ S+E +++ GADK+ I + AL +P LI + Sbjct: 61 FEQLLNLIDKVSSECFMPLSVGGGVNSVEQVRRLVQSGADKVVITTAALENPGLINDASA 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG QCIVVG+D E G Y + + G T+ E ++++++ +RGAGE ++N Sbjct: 121 IFGRQCIVVGLDVKR--EDGAYRLYSHCGRHK----TERELEEFIRDMTQRGAGEFIVNA 174 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 +++DG+ GYDLE +K + V P++A+GGAGT H AF++A+ D + AS+FH Sbjct: 175 VDRDGMMQGYDLEMIKCAKAVTDRPVLAAGGAGTFAHLTAAFQEANADAVVCASIFHFGD 234 Query: 239 INIGELKAYLATQGVEIRI 257 N +++L G+ +++ Sbjct: 235 NNPIRARSHLLNAGIPMKL 253 >UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Arcobacter butzleri RM4018 RepID=A8ESN1_ARCB4 Length = 256 Score = 164 bits (416), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 90/254 (35%), Positives = 142/254 (55%), Gaps = 5/254 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+IPCL + G + K +F+ IGD + K + E+ DEL+F DI AS + R Sbjct: 2 MLQKRVIPCLLLHKGGLYKTEKFKKPTYIGDPINAIKIFNEKEVDELMFIDIDASVEDRE 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + +A +P C GG+K++E KI + G +K+SI+S A+ +P LI A F Sbjct: 62 PNYKMIEDIASECFMPLCYGGGVKNIEQMKKIYALGVEKVSISSQAIINPNLIKEAARLF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q ++V ID D + N+ + + T+ +D++++V+ GAGEIV+N + Sbjct: 122 GNQSVIVTIDIKKD-----FWGNKKIFINNGKKNTKLNPIDFIKQVESLGAGEIVINSCD 176 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ GYD+E LK+++E VP+IA GGAG + H + F + VD S+F Q Sbjct: 177 NDGIMKGYDIELLKEIKENTKVPIIALGGAGNLNHIKDVFESSKVDAVACGSMFVYQGPL 236 Query: 241 IGELKAYLATQGVE 254 G L +Y + Q ++ Sbjct: 237 KGVLISYPSYQKIQ 250 >UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picrophilus torridus RepID=Q6KZD5_PICTO Length = 249 Score = 163 bits (413), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 99/258 (38%), Positives = 154/258 (59%), Gaps = 10/258 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRII LDVR+G+VVKGV+F + + GD V A Y ++GADE+VF DI+A+ + R Sbjct: 1 MLAKRIIAALDVRNGRVVKGVRFMDIKDAGDPVENAVIYQDQGADEIVFLDISATDEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V V+ ++IPF V GGI+S++ A +L G DK+ +N+ A+ +P +I ++ Sbjct: 61 IMIDLVKSVSRELNIPFTVGGGIRSVKTALNLLREGCDKVFLNTYAIENPWIIKEISRET 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLD-WVQEVQKRGAGEIVLNMM 179 G +V+ +D Y+ Y+V + G R+ L+ W+ + GAGEI+L + Sbjct: 121 GSANLVIAVDAMYN---NGYYVYKNAG-----RINSGLKLNEWLPMAEYLGAGEILLTSI 172 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 + DG G+D + + + +P+IASGGAG EHFL+AF ALAAS+ H +I Sbjct: 173 DSDGTMKGFDNRLISEAASMIDIPVIASGGAGKPEHFLDAFMAGASG-ALAASILHFKIN 231 Query: 240 NIGELKAYLATQGVEIRI 257 + ++K YL + GV +R+ Sbjct: 232 TVNDIKRYLRSNGVNVRL 249 >UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJR2_DESAA Length = 262 Score = 162 bits (409), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 99/265 (37%), Positives = 141/265 (53%), Gaps = 13/265 (4%) Query: 1 MLAKRIIPCLDVRDGQ--------VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI 52 ML KR+IP L +R +V V F IGD V AK Y + ADELVF D+ Sbjct: 1 MLKKRLIPKLQMRAASFGKTKRMVLVTTVGFGPSTEIGDPVSQAKIYQAQAADELVFLDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 AS + R +++ AE I +P V GG++S+ED ++L+ GADK+SIN+ A+ P L Sbjct: 61 DASIEHRDALTDIIAKAAEEIFMPITVGGGVRSVEDCRRLLNHGADKVSINTGAMEIPEL 120 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I + +D FG QCIVV ID + G Y V G S T + + W E Q RGAG Sbjct: 121 INQGSDMFGAQCIVVSID-YKKHPNGAYEVFTRGGKSS----TGLDPVAWAVEAQHRGAG 175 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 EI+L +++DG R G +LE KV +P+I SGG G HF++ F A + Sbjct: 176 EILLTSIDRDGTRKGLNLELTAKVAGAVDIPVITSGGCGLASHFVDGFLVGKAHAVSAGT 235 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 F + N + ++ ++ G+ IR+ Sbjct: 236 YFCFKDENPMQTRSRISNAGIPIRL 260 >UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase subunit hisF2 n=17 Tax=delta/epsilon subdivisions RepID=HIS62_CAMJJ Length = 248 Score = 160 bits (405), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 95/257 (36%), Positives = 141/257 (54%), Gaps = 10/257 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML RIIPC+ +++GQ+VK ++F++ IG + + Y DEL+ DI AS G + Sbjct: 1 MLKTRIIPCVLLKNGQLVKSIEFKDFRTIGHLTSTMRIYNARNVDELIILDIDASKSGEI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + +A+ +P + GGIK+LED KIL+ GADKISINS AL D I++ A+RF Sbjct: 61 -DFESIEDLAKECFMPLTIGGGIKTLEDIQKILNLGADKISINSKALEDMDFISKAANRF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV ID + G++ V R + + L+ E +K+GAGE++L ++ Sbjct: 120 GSQCIVCSIDV--KRKGGQFCVYD------RGNLLEKSPLELALEYEKKGAGELLLTSVD 171 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G GYDLE LK + +PLI +GG +EA + D A +FH Sbjct: 172 FEGRAKGYDLELLKIFQNKLKIPLIINGGLSNPSDGVEAL-NLGADALAGAYIFHFSKYT 230 Query: 241 IGELKAYLATQGVEIRI 257 ++K LA QG +R+ Sbjct: 231 PKDVKEELARQGFAVRL 247 >UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase subunit HisF n=1 Tax=Campylobacterales bacterium GD 1 RepID=B6BGE0_9PROT Length = 254 Score = 160 bits (405), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 86/253 (33%), Positives = 146/253 (57%), Gaps = 5/253 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 R+I +D+++ +KG+ +G+ +A RY E+G DE+V D AS R K Sbjct: 5 RVIARIDIKNEHTIKGIHLEGLRKVGNPNEMALRYYEDGIDEIVLMDAVASLYDRNSLKD 64 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 + + E I IP V GG+++L+D + L+ GADK++IN+ A+ +P+ IT + +FG QC Sbjct: 65 VIVKACEDIFIPITVGGGLRNLQDIQEALNSGADKVAINTQAIREPSFITTASKQFGSQC 124 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 I+ I + GK+ G E T + L W +EVQ+ GAGEI+L ++++G Sbjct: 125 IISSI-VAKKIDDGKWEAYIENGREP----TGVDVLAWAKEVQELGAGEIMLTSIDKEGT 179 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 + G+DLE K V E+ ++P+I+SGGAG+ + + +D+D AS+ H ++ ++ E+ Sbjct: 180 KKGFDLELNKAVAELVNIPVISSGGAGSTKDIVHLCESSDIDAVAIASILHYKLESVSEI 239 Query: 245 KAYLATQGVEIRI 257 K L +++RI Sbjct: 240 KKTLINNKIKVRI 252 >UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase subunit hisF3 n=18 Tax=cellular organisms RepID=HIS63_VIBVY Length = 260 Score = 160 bits (404), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 87/234 (37%), Positives = 134/234 (57%), Gaps = 4/234 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L +R+ +VK V+F+ + +GD + K + E+ ADEL DI AS G Sbjct: 6 MLRSRVIPVLLMREKGLVKTVKFKEGKYVGDPLNAVKIFNEQEADELTLLDIDASRLGHE 65 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + R+A +P C GGIK++E A +IL G +K+S++S +P +IT+LA+R Sbjct: 66 PDYVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERV 125 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D K+ G T+ +T+++V+++Q GAGEIVLN ++ Sbjct: 126 GRQSIVVCLDVKKRLFGSKFDCFTING----TKKQSVDTIEFVKQIQTLGAGEIVLNFID 181 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 DGV GYDL+ + K + + VPL GGAG ++ + + + GA A S+F Sbjct: 182 NDGVMKGYDLDAVSKFKALVKVPLTVVGGAGCVDDIAKLVQQEKLVGAAAGSLF 235 >UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E201_GEOLS Length = 282 Score = 157 bits (397), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 97/286 (33%), Positives = 147/286 (51%), Gaps = 33/286 (11%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP LD++ +VKG+ ++GD + A Y E GADEL++ DI AS R Sbjct: 1 MKPVRIIPRLDIKGPNLVKGIHLEGLRVLGDPIAFAHYYYENGADELIYSDIVASLYQRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + IP +AGG+++L D K L GADK+ IN+ A+ +P I + F Sbjct: 61 SILDLVTETSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVRVF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVV ++ + + + YT E+ + + E + WVQ V++ GAGEI+L +N Sbjct: 121 GSSTIVVAVEVVRNDDNS---LIAYT--ENGRQSSGIEAVSWVQRVEELGAGEILLTSIN 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH---KQ 237 +G +GYD++ + +V +P+IA GGAG EH E F +DV A AS+FH K+ Sbjct: 176 AEGTGDGYDMDLINRVVSAVSIPVIAHGGAGKPEHVREVFATSDVRAAAVASMFHYYAKK 235 Query: 238 I-------------------------INIGELKAYLATQGVEIRIC 258 + I+I ELK YL+ G+ R+ Sbjct: 236 LSADMNPVEGNLDFLRSGKSFSRVSEISIVELKQYLSKHGIVCRLV 281 >UniRef50_P72139 Putative imidazole glycerol phosphate synthase subunit hisF2 n=9 Tax=cellular organisms RepID=HIS62_PSEAE Length = 251 Score = 156 bits (395), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 86/234 (36%), Positives = 134/234 (57%), Gaps = 5/234 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ +R+IPCL ++D +VK V+F+ + +GD + + + E+ DEL+ DI AS + Sbjct: 1 MVRRRVIPCLLLKDRGLVKTVKFKEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQE 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ VA +P C GGIK+LE A KI S G +K+SIN+ AL D +LI R+AD+F Sbjct: 61 PNYELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V ID G E+ TR + L+W Q +++ G GEI LN ++ Sbjct: 121 GSQSVVGSIDCRKGFWGG-----HSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 +DGV+ G+D ++ + HVP+IA GGAG++ ++ F V A S+F Sbjct: 176 RDGVQKGFDNALVENIASNVHVPVIACGGAGSIADLIDLFERTCVSAVAAGSLF 229 >UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winogradskyi Nb-255 RepID=Q3SPZ7_NITWN Length = 258 Score = 154 bits (389), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 94/261 (36%), Positives = 146/261 (55%), Gaps = 15/261 (5%) Query: 1 MLAKRIIPCLDVRDGQVVK-GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ML KR+IP +RDG++VK F N I G+ V AK Y + G DEL+ DI S+ R Sbjct: 1 MLKKRLIPKFLLRDGRLVKYTCFFDNERIAGNPVTTAKVYNDYGVDELIVLDIVPSAASR 60 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + + R++E I +PF V GG+K+ ED +L GADK+SINS A+ P + A Sbjct: 61 ARVEDIIGRMSEEIFMPFTVGGGVKTAEDVNALLRAGADKVSINSEAVRRPEFVREAART 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG QCI V ID G +H + Y D R V + ++W + GEI+++ + Sbjct: 121 FGDQCITVSIDY---KRIGSHHASVYI-DGGREHVA-LDPVEWALRCEDLHCGEILMSSI 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF----H 235 ++DG GYDLE + + + VP+I SGG G+++H ++A +A +S+F H Sbjct: 176 DRDGTMQGYDLEMINTLTKRLGVPMIVSGGCGSLQHAIDAL-EAGASAVAISSMFLFTDH 234 Query: 236 KQIINIGELKAYLATQGVEIR 256 I +L+++LA++G+++R Sbjct: 235 SPI----KLRSHLASRGLDVR 251 >UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Prochlorococcus marinus RepID=A2C5V2_PROM3 Length = 500 Score = 154 bits (389), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 88/255 (34%), Positives = 142/255 (55%), Gaps = 5/255 (1%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L+KRII LDV+ +++KGV+F +IGD + +A++YA+ G DEL++ D AS GR Sbjct: 15 LSKRIIARLDVKGNKIIKGVRFEGLRVIGDPLDMARKYAKAGIDELLYIDAVASLYGRNS 74 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + IP GGI++LEDA +LS GADKI+IN+ AL P LI+ L++ G Sbjct: 75 LIEVLKSTSSEVFIPITAGGGIRNLEDAKLLLSNGADKIAINTAALECPQLISELSNTLG 134 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QC+VV I + + + + +G E + + + W++ VQ GAGEI+L ++Q Sbjct: 135 SQCVVVSIQARASSSS-SWDAMKESGREK----SGIDVIKWIENVQLLGAGEILLTSVDQ 189 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG D ++KV + +PLI SGG +A ++ + + H Q N+ Sbjct: 190 DGTCIKPDEILIQKVLPILKLPLIVSGGFSDPNQVYQALTNSRISAVAIGAALHYQKTNV 249 Query: 242 GELKAYLATQGVEIR 256 ++K+ L+ + IR Sbjct: 250 SDIKSMLSFNNIAIR 264 >UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Roseburia RepID=C7GBG4_9FIRM Length = 252 Score = 153 bits (386), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 95/257 (36%), Positives = 135/257 (52%), Gaps = 6/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L + +VKGV F + + ++P K Y DEL+ DI A+++ R Sbjct: 1 MLKVRVIPTLLYKSVGLVKGVGFNSWRRVDTVLPAIKVYNMREVDELILLDIEATNEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + + +PFCV GGI ++ +L GADK++INS A + +LIT A F Sbjct: 61 PDYDEIRDFSRECFVPFCVGGGICHIDQIKNLLRAGADKVAINSAAYDNLSLITEGAKLF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV ID G+YH + G T W DW+ +V + GAGEI+L + Sbjct: 121 GSQCIVASIDC--RKIDGEYHCFSHNGSVD----TGWLLQDWIIKVVEAGAGEILLTSVE 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG GYD+E +K + +VP+IASGGAG EH +A ++ AAS++H Sbjct: 175 LDGTMEGYDVEMIKIATSLVNVPVIASGGAGNYEHMRKAVQEGGASAVAAASIYHFTEQT 234 Query: 241 IGELKAYLATQGVEIRI 257 E K YL GV +R+ Sbjct: 235 PKEAKEYLGEHGVAVRM 251 >UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria RepID=B4SDB6_PELPB Length = 256 Score = 149 bits (376), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 87/252 (34%), Positives = 135/252 (53%), Gaps = 5/252 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 R+I LD++ ++KG+ +IG A RY ++G DEL++ D AS R Sbjct: 5 RLIARLDIKGPNLIKGIHLEGLRVIGSPNEYALRYYQQGVDELIYMDCVASLYDRNHLGD 64 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 + A+ I +P V GGI+S+EDA +IL GADK+++N+ A+A+P LI ++ RFG QC Sbjct: 65 IIRSAAKDIFVPMTVGGGIRSVEDATQILRSGADKVAVNTAAVANPKLINEISRRFGSQC 124 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 +V+ I+ E GK YT D R R T + + WV++ GAGE++L ++++G Sbjct: 125 MVLSIEA---KEVGKDRWEVYT-DNGRER-TGLDVIAWVKKGVAMGAGEVLLTSVDREGT 179 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 R G+D +K V +P+IASGG G E + D A + H IGE+ Sbjct: 180 RKGFDTALVKAVTAEVSIPVIASGGMGKPEDLVGVVSVGGADAVAMADILHYNRAGIGEI 239 Query: 245 KAYLATQGVEIR 256 + G+ +R Sbjct: 240 RNVAKETGMGVR 251 >UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Prochlorococcus marinus str. MIT 9313 RepID=HIS62_PROMM Length = 261 Score = 146 bits (368), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 85/265 (32%), Positives = 139/265 (52%), Gaps = 14/265 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKGV--------QFRNHEIIGDIVPLAKRYAEEGADELVFYDI 52 ML KR+IP L +G QF + IGD V AK Y + ADELV D+ Sbjct: 1 MLKKRLIPKLQFSIKPSYRGPKPVLVITRQFDSKRAIGDPVSQAKIYEAQLADELVLVDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 +SD + +S ++E + P V GGI S E ++L GADK+ +NS A+ +P L Sbjct: 61 EGTSDSWPILLDTLSNMSESLATPLSVGGGITSFEQVQQLLDRGADKVVLNSGAVNNPQL 120 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I +A+ +G QC+V+ ID +++ + HV G + T W W + RGAG Sbjct: 121 IDLVANSYGSQCVVISIDIRKESDLSR-HVYIDGG----STATDWSLFSWANDCASRGAG 175 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 E+++ ++ DG G DL+ ++++R ++PLIASGG G +HF+ + + A + Sbjct: 176 ELLITSIDNDGTGTGLDLDSIRQLRYEVNLPLIASGGCGLAQHFVAGY-EVGASAVAAGT 234 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 F ++ N + ++++ G+ IR+ Sbjct: 235 FFSQRDQNPMQCRSHIRNAGLPIRL 259 >UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BNI2_9BACT Length = 248 Score = 144 bits (364), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 74/235 (31%), Positives = 127/235 (54%), Gaps = 9/235 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML RIIP L +VK F+N ++G+ V A+ + G DEL+F DI A+ R Sbjct: 1 MLKNRIIPILTFNGLGLVKTKGFKNPRMVGNPVQTARVFNSRGVDELIFLDIYATKQSRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ S V V + +P + GGI++++ +L GADK+ I S AL D + + F Sbjct: 61 INLSLVKEVIKECYMPVSIGGGIQTIDQINDLLKIGADKVVIKSKALTDKKFLKEAINFF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI + +D + + N ++ +++ E ++ E+ AGE+++N +N Sbjct: 121 GSQCICISVDVLF------VNNNYLIYNDLGLKISLEE---FITEMSLINAGELLVNSVN 171 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 DGV NG+D++ + KV ++ +P+IA+GG G EH+ F ++ ++S+FH Sbjct: 172 NDGVMNGFDIDLINKVEQMTTIPVIAAGGGGEPEHYSTLFNKTKINAVASSSIFH 226 >UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit HisF n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BR00_9RICK Length = 254 Score = 144 bits (363), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 78/238 (32%), Positives = 129/238 (54%), Gaps = 14/238 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE-IIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ML RII + +VKG +F N + G + K Y DE++F+DI S + + Sbjct: 1 MLKARIITTMLWNGSTLVKGNKFENEKRSAGSPLTTVKIYNSRDVDEILFFDI--SRNNK 58 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 ++DK ++ + + + +P + GGI+ + + +GADK++INS +P +I + R Sbjct: 59 IIDKDFILSITDCVSVPITIGGGIEKISQMNDLFEYGADKVAINSIIYKNPNIIDEASKR 118 Query: 120 FGVQCIVVGIDTWYDAETGK--YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 FG Q I V ID + + + Y + + D D + E RGAGEIV+N Sbjct: 119 FGSQAITVSIDVRKNNQNYECYYDLGKIKSDRKLN--------DLLVECVNRGAGEIVIN 170 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 +N DG+ GYD E +++ + ++P++ASGGAG+ EHF EA+++ D AAS++H Sbjct: 171 CINNDGLMKGYDNELIQQTSSLANIPIVASGGAGSYEHFYEAYKNG-ADAFAAASIYH 227 >UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Proteobacteria RepID=A6T0B3_JANMA Length = 253 Score = 139 bits (349), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 79/247 (31%), Positives = 136/247 (55%), Gaps = 5/247 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLA R++PCL + G +VK VQF+ IGD V + + ++ DEL+ DITA+++ R Sbjct: 1 MLAIRVMPCLLMDQGALVKTVQFKKPTYIGDPVNAVRIFNQKEVDELLLIDITATTEKRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +D + ++ +P C GG+ +L D ++ G +KIS+++ A+ +P L+ A F Sbjct: 61 IDFETLEKLVTECFMPICYGGGVDNLVDMRRLYHLGIEKISLSAAAITNPELVREAAAEF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D + GK+ V + G T+ ++ +E+++ GAGEI+L ++ Sbjct: 121 GNQAIVVTLDVKKNL-FGKHTVRTHQGKTD----TKRSPVEVAREMEQAGAGEILLYSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G+DL+ ++ V +P+IA GGAG + H A +A S+ Q + Sbjct: 176 KDGTWSGFDLDLIQNVTRAVGIPVIACGGAGELAHLRSAVNEAGASAVAIGSMAVFQAKD 235 Query: 241 IGELKAY 247 +G L + Sbjct: 236 LGVLIKF 242 >UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L5A7_9DELT Length = 261 Score = 137 bits (344), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 82/219 (37%), Positives = 125/219 (57%), Gaps = 8/219 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD-GR 59 ML KR+IP + V+ G VV+ + FR + +G + + DE+V I D R Sbjct: 1 MLKKRLIPVVLVKQGLVVQSIGFRRYLPVGRPKITVEFFNRWDCDEIVLLAIDREPDLAR 60 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + + V+ +P V GG++ +ED ++L GADK+S+N+ A DP LITR A+ Sbjct: 61 LA--GLTAHVSGAAFVPLTVGGGVRRIEDFQELLRAGADKVSLNTAAFRDPELITRAAEA 118 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG Q +VV ID A+ G+Y V G E+ T + D+ +E ++RGAGEI+LN + Sbjct: 119 FGNQEVVVSIDARRHAD-GRYEVFVGGGREA----TGADPRDFAREAERRGAGEILLNAI 173 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 ++DG + GYDLE +++V +P+IA GG G +EH E Sbjct: 174 DRDGGKQGYDLELVRRVATAVSIPVIALGGVGRIEHVPE 212 >UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SPR8_NEMVE Length = 545 Score = 137 bits (344), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 104/334 (31%), Positives = 165/334 (49%), Gaps = 80/334 (23%) Query: 2 LAKRIIPCLDVRD---GQVV--KGVQFRNHEII----------------GDIVPLAKRYA 40 LAKR+I L+VR G++V KG QF EII GD V L +R+ Sbjct: 214 LAKRVITSLNVRTNNMGELVATKGEQFEVREIISDDEGNKPVKGDVKAVGDPVELGERFF 273 Query: 41 EEGADELVFYDITASSDGRVVDKSWVS---RVAEVIDIPFCVAGGIK------------- 84 +GADE+ F +IT+ + D + + + E I +PF V GGI+ Sbjct: 274 SDGADEIAFLNITSFRSSPIHDLAMLKLLRKCCERIFVPFTVGGGIRDIYALDPDSVEEG 333 Query: 85 --------SLEDAAKILSFGADKISINSPAL-------------ADPTLITRLADRFGVQ 123 +LE AA GADK+S+ S A+ T I ++A+R+G Q Sbjct: 334 KPVMRQFSALEVAAMYFKSGADKVSVASDAVYAAEEFIASGHKKTGKTSIEKIAERYGRQ 393 Query: 124 CIVVGIDTWY----DAETGKYHV--NQYTGDESRTRVTQW---------ETLD-----WV 163 +V+ +DT ++ K+H +Y G V W ET D V Sbjct: 394 AVVLAVDTKTVYVPSPDSTKHHTVKARYPGPNGEKYV--WWQCTVKGGRETRDVGAYELV 451 Query: 164 QEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA 223 + ++ GAGEI+LN +++DG +GYDL+ +K V+ +P+IAS GAG + F++ FR+ Sbjct: 452 KACEELGAGEILLNNIDRDGTNHGYDLDLVKMVKGAVSIPVIASSGAGHVSDFVDLFRET 511 Query: 224 DVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 + DGA+A ++FH+ ++I ++K +L +G +R+ Sbjct: 512 NADGAMAGAIFHRGEVDITDVKEHLRNEGFTVRL 545 >UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hisF n=2 Tax=Bacteria RepID=C9YDK8_9BURK Length = 286 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 93/256 (36%), Positives = 136/256 (53%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L + +VKGV F + +G ++P K Y + DELV DI A G Sbjct: 27 MLKVRVIPTLLWKHFGLVKGVGFNSWRRVGPVLPAIKVYNQREVDELVLVDILAHGRGEE 86 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + + +P V GGI +E ++L GADK+S+N+ A A P L++ +A R Sbjct: 87 PDYESIHEFGQDCFVPLTVGGGITHIEQVQRLLRVGADKVSLNTAAYARPELVSDIARRH 146 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 GVQC+V ID A G + + G T+ T + + W +E++ RGAGEI++ ++ Sbjct: 147 GVQCVVASIDVRPRA-GGGWDCFSHAG----TQPTGRDVVAWARELEDRGAGEILVTSID 201 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG GYDL + V + +P+IASGGAG +H ++A A AAS+FH + Sbjct: 202 LDGSMRGYDLALVAAVAQAVKIPVIASGGAGNYQHMVDAVVQAGAAAVAAASIFHFTEMT 261 Query: 241 IGELKAYLATQGVEIR 256 KA LA GV +R Sbjct: 262 PAGAKAALAEAGVPVR 277 >UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7I5_9DELT Length = 289 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 81/235 (34%), Positives = 119/235 (50%), Gaps = 5/235 (2%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 RIIP LD++ +VKG+ F ++G A+ Y E GADEL F D AS R Sbjct: 4 RIIPRLDIKGPNLVKGIHFEGLRVLGKPEDFARHYYENGADELFFQDAVASLYDRNSLHD 63 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 V R + I IP CV GG++S++D +L GADK++IN+ A+ P LI + FG Sbjct: 64 IVKRTSSEIFIPLCVGGGLRSVDDIRAVLRAGADKVAINTEAIKRPELIREASVAFGSST 123 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 IVV I+ A G++ G E+ T ++W + + GAGE+++ ++Q+G Sbjct: 124 IVVSIEAIRRA-NGEWEALVEYGRET----TGVNAVEWAKRACELGAGELMITSIDQEGT 178 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 GYD+E + + VP+IA GG G+ D ASV H + I Sbjct: 179 GKGYDIELTRAIASAVSVPVIAGGGCGSPADAANVITQGRADAVSMASVLHYKTI 233 >UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=uncultured marine bacterium 440 RepID=Q6SHC0_9BACT Length = 262 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 78/242 (32%), Positives = 132/242 (54%), Gaps = 17/242 (7%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD---GR-- 59 RIIP L +++G +V+ F H+ IG+++ AKR + DELV+ DIT + + GR Sbjct: 6 RIIPVLFIKNGLIVRSQNFYKHQFIGNVIEQAKRLNDYDVDELVYIDITRNDNYDLGRDD 65 Query: 60 --VVDK----SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 V K S + +++V +P GGI+S++DA + GADKI+INS D ++ Sbjct: 66 LLVKSKRDIMSIIKDISKVCFMPLTFGGGIRSVDDAVNRIRAGADKITINSLLYKDLNIV 125 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 ++ G Q +V ID Y K + G ++ T E +D++++++ G GE Sbjct: 126 KKIISEIGSQAVVASID--YKIINEKLIIFNNFGQDN----TNIELIDFIKKIENLGVGE 179 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 + + DG++ G+DL +KK+ ++P+IA GAG++EHFLEA + + A + Sbjct: 180 FFIQNVELDGMQKGFDLNNIKKIVNSVNLPVIACSGAGSLEHFLEAVKIKGLSAVAAGNY 239 Query: 234 FH 235 F+ Sbjct: 240 FN 241 >UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WSE3_VEREI Length = 229 Score = 134 bits (337), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 82/218 (37%), Positives = 120/218 (55%), Gaps = 6/218 (2%) Query: 39 YAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGAD 98 Y +GADELVF DI AS R + R A+ I +P V GGI+SL D +L GAD Sbjct: 17 YYSQGADELVFMDIVASLYQRNNLAGIIERAADQIYVPITVGGGIRSLHDVRTMLCSGAD 76 Query: 99 KISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWE 158 K++IN+ A+A P LI +++RFG QC+V+ ++ + G + G E T + Sbjct: 77 KVAINTAAVARPGLIAEVSERFGSQCMVLSVEAKRKS-GGGWEAFVDNGREH----TGLD 131 Query: 159 TLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 + WV++ GAGEI+L ++Q+G R G+D++ ++ V VP+IASGG G + Sbjct: 132 VVAWVRQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTVAGCVTVPIIASGGYGRPSDLQQ 191 Query: 219 AFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIR 256 A +A G A H Q I ELKA+ G+E+R Sbjct: 192 AA-EAGASGLAIADALHWQRATIAELKAHARAAGLEVR 228 >UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C5E2I9_LACTC Length = 550 Score = 133 bits (335), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 100/318 (31%), Positives = 148/318 (46%), Gaps = 66/318 (20%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFR--------NHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ N +G V LA++Y E+GADE+ Sbjct: 234 LTRRIIACLDVRTNDQGDLVVTKGDQYDVREKQEGGNVRNLGKPVELAQKYYEQGADEVT 293 Query: 49 FYDITASSDGRVVDKSWV---SRVAEVIDIPFCVAGGIKSLED-----------AAKILS 94 F +IT+ D + D + + A+ + +P V GGIK + D AA + Sbjct: 294 FLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTHIPALQVAALYFA 353 Query: 95 FGADKISINSPALADPTLITRLADR-------------FGVQCIVVGID----------- 130 GADK+SI S A+ L +R +G Q +V+ +D Sbjct: 354 SGADKVSIGSDAVYAAEKYYELGERGDGASPIETISKSYGAQAVVISVDPKRVYVDGPES 413 Query: 131 -------TWYDAETGK----YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 T + E G+ Y G ESR + WE + + GAGE++LN + Sbjct: 414 VKHKTFETKFPNEKGQTWCWYQCTIKGGRESRD-MGVWE---LTRACEALGAGEVLLNCI 469 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG +GYDLE + +E +P+IAS GAG +HF EAF D L A +FH+ Sbjct: 470 DKDGSNSGYDLELINHAKEAVKIPVIASSGAGEPKHFKEAFESTGADACLGAGMFHRGEY 529 Query: 240 NIGELKAYLATQGVEIRI 257 + ++K YL G ++R+ Sbjct: 530 TVNDVKQYLLDSGFKVRM 547 >UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_YEAST Length = 552 Score = 133 bits (334), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 100/318 (31%), Positives = 150/318 (47%), Gaps = 66/318 (20%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFRNHEI--------IGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ E +G V LA++Y ++GADE+ Sbjct: 236 LTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVT 295 Query: 49 FYDITASSDGRVVDKSWV---SRVAEVIDIPFCVAGGIK-----------SLEDAAKILS 94 F +IT+ D + D + + A+ + +P V GGIK +LE A+ Sbjct: 296 FLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFR 355 Query: 95 FGADKISINSPALADPTLITRLADR-------------FGVQCIVVGID----------- 130 GADK+SI + A+ L +R +G Q +V+ +D Sbjct: 356 SGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQAD 415 Query: 131 -------TWYDAETGK----YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 T Y G+ Y G ESR + WE + + GAGEI+LN + Sbjct: 416 TKNKVFETEYPGPNGEKYCWYQCTIKGGRESRD-LGVWE---LTRACEALGAGEILLNCI 471 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG +GYDLE ++ V++ +P+IAS GAG EHF EAF D L A +FH+ Sbjct: 472 DKDGSNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEF 531 Query: 240 NIGELKAYLATQGVEIRI 257 + ++K YL G+++R+ Sbjct: 532 TVNDVKEYLLEHGLKVRM 549 >UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Prochlorococcus marinus str. NATL1A RepID=A2C1S3_PROM1 Length = 248 Score = 132 bits (331), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 74/234 (31%), Positives = 131/234 (55%), Gaps = 7/234 (2%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 RII LDV++ V+KG+ +GD LA Y ++G +E+VF D AS R Sbjct: 2 RIIGRLDVKNNHVIKGIHLEGLRKVGDPQELAVEYYKQGIEEIVFMDAVASLYNRNNLFH 61 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 + + E + +P + GG++SL+D +K L+ GADK+ IN+ + L +A ++G QC Sbjct: 62 IIQKACEKVFVPIALGGGLRSLDDVSKALNAGADKVVINTALVNRIDLAKEIAQKYGSQC 121 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 +V I+ + ++ + +V+ G E T+ +DW ++++ G GEI+L ++Q+G Sbjct: 122 LVGSIEAKRENDSWRVYVD--NGREP----TKHNVVDWAIKLKEAGVGEILLTSIDQEGT 175 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDG-ALAASVFHKQ 237 G+D+E +K++ E P+IASGG G +H + + + A+A S+ +K+ Sbjct: 176 SKGFDIELIKQINESIRCPIIASGGYGNKKHLADLLKIVEPSAIAIAGSLHYKK 229 >UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n=3 Tax=Basidiomycota RepID=Q5KNA0_CRYNE Length = 619 Score = 130 bits (328), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 99/331 (29%), Positives = 150/331 (45%), Gaps = 76/331 (22%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFRNHEI--------IGDIVPLAKRYAEEGADELV 48 L RI+ CLDVR D V KG Q+ E +G V LA+RY GADE+ Sbjct: 282 LTNRIVACLDVRSNDAGDLVVTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVA 341 Query: 49 FYDITASSDGRVVDKSW---VSRVAEVIDIPFCVAGGIK-----------SLEDAAKILS 94 F +IT+ ++D+ V AE + +P + GGIK +LE A Sbjct: 342 FLNITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFR 401 Query: 95 FGADKISINS-----------------PALADPTLITRLADRFGVQCIVVGIDT------ 131 GADK+SI S PAL T I ++ +G Q +VV ID Sbjct: 402 SGADKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVD 461 Query: 132 -----WYDAETGKYHVNQYTGDESRTRVTQWE---------------------TLDWVQE 165 W ++ K+ + GD + +R E + Q Sbjct: 462 TSAPGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQCTISGGRAVRDIDVVQLAQG 521 Query: 166 VQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADV 225 V++ GAGEI+LN +++DG G+DL+ +K V+ +P+++S GAG+ F E FR+ Sbjct: 522 VERLGAGEILLNSVDRDGSGQGFDLDLVKLVKNAVGIPVVSSSGAGSPADFEEVFRETGT 581 Query: 226 DGALAASVFHKQIINIGELKAYLATQGVEIR 256 + ALAA +FH+ + I E+K +L + + +R Sbjct: 582 EAALAAGIFHRGEVGIDEVKGWLEGKEMAVR 612 >UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) n=8 Tax=Saccharomycetales RepID=C4R8P0_PICPG Length = 561 Score = 130 bits (327), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 98/316 (31%), Positives = 151/316 (47%), Gaps = 64/316 (20%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQF--RNHEIIGDI------VPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ R GD+ V +A++Y ++GADE+ Sbjct: 246 LTRRIIACLDVRTNDSGDLVVTKGDQYDVREKSESGDVRNLGKPVEMAEKYYQQGADEVT 305 Query: 49 FYDITASSDGRVVDKSWV---SRVAEVIDIPFCVAGGIKSLED-------AAKILSF--- 95 F +IT+ + + D + R AE + +P V GGIK + D A K+ + Sbjct: 306 FLNITSFRNSPIKDAPMLEVLKRAAETVFVPLTVGGGIKDVVDPDGTKVPALKVATLYFR 365 Query: 96 -GADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGIDT--WYDAETGK 139 GADK+SI + A+ T I ++ +GVQ +V+ +D +Y A+ K Sbjct: 366 AGADKVSIGTDAVLAAEEFYRNNEKGTGLTPIETISASYGVQAVVISVDPKRFYVADPSK 425 Query: 140 -------------------YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Y+ G + + WE +K GAGEI+ N ++ Sbjct: 426 TPYKTIKTKFPGPNGENYCYYKVTSQGGRNVHDLGAWE---LCYACEKLGAGEILCNCID 482 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +GYDLE + ++ +P+IAS GAG HF E FR + D AL A +FH+ Sbjct: 483 KDGSNSGYDLELIDYIKSATKLPVIASSGAGNPSHFEEVFRKTETDAALGAGMFHRGEYT 542 Query: 241 IGELKAYLATQGVEIR 256 + E+K +L +G+ +R Sbjct: 543 VKEVKDFLTKRGLLVR 558 >UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Vibrio vulnificus YJ016 RepID=HIS62_VIBVY Length = 272 Score = 129 bits (324), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 87/257 (33%), Positives = 132/257 (51%), Gaps = 6/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IPC+ + VV+ F+N+ IG++ + DE++ DI AS + R Sbjct: 4 MLKIRLIPCIVTKGELVVQSFAFKNYLPIGNVKTAIDFFVNWDVDEIIVNDIDASKEFRE 63 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + VS A+ +P V GGIK+LE +L GADK++IN+ A+ DP I A F Sbjct: 64 PNVDLVSWAAKECFVPLTVGGGIKTLEHIRNLLKAGADKVTINTKAIDDPDFIKNAASVF 123 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI V +D K + D RV + +DWV++V+ GAGEI+LN ++ Sbjct: 124 GSQCITVSVDAIKQGNVYKLY------DYRDGRVLDVDVVDWVRKVESYGAGEILLNSVD 177 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG R GYD+E LK V + +P+IA GG G + E + AA++F + Sbjct: 178 RDGSREGYDVELLKTVSGIVSIPVIALGGIGRFDQLAEGAIEGGCQALSAANIFQHMEHS 237 Query: 241 IGELKAYLATQGVEIRI 257 KA + + +R+ Sbjct: 238 TIAAKAQMRNAKLNVRL 254 >UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UE29_9RHOB Length = 261 Score = 127 bits (318), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 78/232 (33%), Positives = 124/232 (53%), Gaps = 17/232 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS---D 57 ML R+IP L + +GQ+V+ F H+IIGD + R+ E DEL++ DI+ ++ Sbjct: 1 MLMPRLIPVLLLMNGQLVRSETFTTHQIIGDPLHEVARFNEWKVDELIYLDISRTAGLAQ 60 Query: 58 GR--VVDKSW------VSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALAD 109 GR ++++ + VA +P G + SL+ I GADK++IN+ A Sbjct: 61 GRRDAGNRAYADAMDVLEAVASHCFMPLTWGGHVTSLDQVRDIFKRGADKVAINTAAYET 120 Query: 110 PTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR 169 P LIT+++ RFG Q +VV ID E G Y V G + R + + W +E + R Sbjct: 121 PDLITQVSKRFGAQAMVVSIDA-RQIENG-YEVMTQGGRTATGR----DPVSWAKEAEDR 174 Query: 170 GAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR 221 GAGEI+L +++DG GYD +++V + +P+IA G G EH+ + + Sbjct: 175 GAGEILLQSLDRDGRGTGYDTTLIEQVSQAVTIPVIACSGVGVYEHYAKGLK 226 >UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8LDL7_THAPS Length = 570 Score = 124 bits (311), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 103/328 (31%), Positives = 151/328 (46%), Gaps = 75/328 (22%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQF--RNHEI------------IGDIVPLAKRYAEE 42 L KR++ LDVR D V KG Q+ R +E +G V LA RY +E Sbjct: 244 LVKRVVVALDVRSNDHGDLVVTKGDQYDVRENEKEGVQEGRGGVRNLGKPVSLASRYYKE 303 Query: 43 GADELVFYDITASSDGRVVDKSWVSRVAEV---IDIPFCVAGGIKSLED----------- 88 GADE+ F +IT+ G + D + + E I +P V GGI+S ED Sbjct: 304 GADEIAFLNITSFRSGVIEDMPMLQVLEEASKEIFVPLTVGGGIRSYEDPGTGKVYSALE 363 Query: 89 -AAKILSFGADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGID---- 130 A++ GADK+SI S ++ T I ++ +GVQ +V+ ID Sbjct: 364 VASRYFRAGADKVSIGSDSVHAAEEYIASGNTKTGQTSIETISHVYGVQAVVISIDPKRV 423 Query: 131 --TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQ-------------------EVQKR 169 T DA K+ V T D+S+ + E W Q + Sbjct: 424 YVTSPDAADSKHTV--VTLDDSQ-KGPNGEQYCWYQCTVKGGREARDICAVSVAKAAEAL 480 Query: 170 GAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGAL 229 GAGEI+LN ++ DG NG+D +K V + +P+IAS GAG HF + F + V AL Sbjct: 481 GAGEIMLNCIDMDGQCNGFDHALMKAVSDAVTIPVIASSGAGKESHFSDVFSETSVQAAL 540 Query: 230 AASVFHKQIINIGELKAYLATQGVEIRI 257 AA +FH++ + I ++K ++ G+ RI Sbjct: 541 AAGMFHRKEVEIADVKKHMEKMGIRARI 568 >UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes: glutamine amidotransferase; cyclase], putative n=6 Tax=cellular organisms RepID=B9WJS1_CANDC Length = 622 Score = 121 bits (304), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 100/330 (30%), Positives = 153/330 (46%), Gaps = 75/330 (22%) Query: 2 LAKRIIPCLDVR---DGQVV--KGVQFRNHE----------------IIGDIVPLAKRYA 40 L +RII CLDVR DG +V KG Q+ E +G V LA +Y Sbjct: 288 LTRRIIACLDVRTNDDGDLVVTKGDQYNVREQQSSSSKISENSNQVRNLGKPVELATKYY 347 Query: 41 EEGADELVFYDITASSDGRVVDKSWVS---RVAEVIDIPFCVAGGIKSLEDA--AKI--- 92 +GADE+ F +IT+ + + D + + AE I +P V GGIK L D+ KI Sbjct: 348 NQGADEITFLNITSFRNSPLKDLPMLQVLRKSAETIFVPLTVGGGIKDLYDSETKKIIPA 407 Query: 93 -----LSF--GADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGIDT- 131 L F GADKISI S A+ + I ++ +FG Q +V+ +D Sbjct: 408 VDIAHLYFQSGADKISIGSDAVIIAENYYANNQIPLGTSSIETISSKFGNQAVVISVDPK 467 Query: 132 ----------------------WYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR 169 Y +Y Q T R ++ + L+ +K Sbjct: 468 RKYIKNPQLDTTMETIKIIDPLQYGPNGEQYCYYQVTSQGGR-KLHELGALELCLACEKL 526 Query: 170 GAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-DADVDGA 228 GAGEI+LN ++ DG G++L+ L++++ +P+IAS GAG +HF + F D +D A Sbjct: 527 GAGEILLNSIDNDGSNKGFNLQLLQQIKSHVSIPVIASSGAGNPQHFQQVFEMDCGIDAA 586 Query: 229 LAASVFHKQIINIGELKAYLATQG-VEIRI 257 L A +FH+ + E+K YL + +++R+ Sbjct: 587 LGAGIFHRGEYTVNEVKKYLQQEAKMDVRL 616 >UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID=Q1N2Y7_9GAMM Length = 223 Score = 121 bits (304), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 71/231 (30%), Positives = 124/231 (53%), Gaps = 10/231 (4%) Query: 28 IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLE 87 ++GD + K ++ ADE+V DI A+ R+ + + R++ +P + GG+ +LE Sbjct: 1 MVGDAITNVKVFSSRKADEMVIVDIEATEKKRI-NLPLLKRLSSHCIMPLTIGGGVTTLE 59 Query: 88 DAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTG 147 DA + S GADK+ +NS P ++T ++ +FG Q +V +D + N+Y Sbjct: 60 DAEDLFSVGADKVLVNSAFYNRPEILTDISSKFGRQAVVFSLDVMKKS-------NEYVP 112 Query: 148 DESRTRVTQ-WETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIA 206 V Q W + V+ + GAGEI+LN ++ DG+ G+DL K+V ++ VP++ Sbjct: 113 VSKNGSVKQSWTLRETVERAIEYGAGEIILNSVDCDGMMQGFDLNLCKQVSDISSVPVVI 172 Query: 207 SGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 +GG GT E + A ++ D A S+F+ +I +K Y+ G+E+R+ Sbjct: 173 AGGCGTKEDCVLAV-NSGADAVAAGSIFYWVGESILTIKDYMNKNGLEVRL 222 >UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase HisF n=1 Tax=Sphingobacterium spiritivorum ATCC 33300 RepID=C2G0W0_9SPHI Length = 263 Score = 120 bits (302), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 77/239 (32%), Positives = 121/239 (50%), Gaps = 11/239 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEE----GADELVFYDITASS 56 ML KR+I L DG ++ FR ++ GDI L K Y DELV +++ S Sbjct: 1 MLRKRVIFTLLYCDGFFMQSRNFRLQKV-GDINWLEKFYKFNKIAFSLDELVILNVSRKS 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + VSR+ E +P V GGI+SLEDA + GADKI +N+ +DP L+ + Sbjct: 60 KNQEEFGRTVSRLVEGTYMPVAVGGGIRSLEDAEMLFKSGADKIVLNTSLSSDPDLVKLI 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 ++G Q +V ID E+ + + E+ + +++ ++ GE+ L Sbjct: 120 VQKYGSQSVVASIDYLKKGESSEIFI------ENGSLNINEGFENYLSHLKDLNVGEVYL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 N M +DG GYD +K V+ + +VPLI +GGAG H EA +++ A A++F+ Sbjct: 174 NSMERDGTGFGYDFSLVKLVKSILNVPLIIAGGAGNEGHLKEALLHSEISAAATANLFN 232 >UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms RepID=C1FJN8_9CHLO Length = 601 Score = 118 bits (296), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 97/315 (30%), Positives = 141/315 (44%), Gaps = 78/315 (24%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFRNHEI--------IGDIVPLAKRYAEEGADELV 48 LAKR+I CLDVR D V KG + E +G V LA +Y ++GADE+ Sbjct: 283 LAKRVIACLDVRSNDAGDLVVTKGDSYDVREKDDGNDVRNLGKPVELAGKYFKQGADEVA 342 Query: 49 FYDITASSDGRVVDKSWVS---RVAEVIDIPFCVAGGIK-----------SLEDAAKILS 94 F +IT D + D + R +E + +P V GGI+ +LE AA Sbjct: 343 FLNITGYRDLPLTDAPMLEVLRRSSETVFVPLTVGGGIRDFTDSNGVSYTALEVAAAYFK 402 Query: 95 FGADKISINSPALA-------------DPTLITRLADRFGVQCIVVGIDTWYDAETGKYH 141 GADK+SI S A+ T I ++++R+GVQ +VV ID Sbjct: 403 AGADKVSIGSDAVYVAEQYYANDKKKDGCTSIEQISERYGVQAMVVSIDPR--------- 453 Query: 142 VNQYTGDESRTRV---------TQWETLDWVQ-------------------EVQKRGAGE 173 Y D S T+ E W Q ++ G GE Sbjct: 454 -RAYVADPSETKNRCIKTSRPGPNGEEYVWFQCTVKGGREGRDIGAYELAIAMEDLGCGE 512 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 I+LN +++DG NG+D E + V + +P+IAS GAG +HF + F ALAA + Sbjct: 513 ILLNCIDEDGQGNGFDHELVGLVADAVTIPVIASSGAGEPKHFTDVFNATKCSAALAAGI 572 Query: 234 FHKQIINIGELKAYL 248 FH+ ++I E+K ++ Sbjct: 573 FHRGEVDISEVKDHM 587 >UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6XVQ0_PEDHD Length = 288 Score = 113 bits (283), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 73/221 (33%), Positives = 116/221 (52%), Gaps = 8/221 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+ L V+DG VV+ + F+ + +G + + G DE++ DI+A+ Sbjct: 1 MLKKRVAANLVVKDGIVVQSIGFKKYLPVGKPEIAIEFLNQWGIDEIILTDISATRKQSG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + R A+ +P V GGI + ++L GADKIS+N+ A+ P LIT A F Sbjct: 61 PDFDMIRRAAQKCFVPLTVGGGISNTGQMKELLHNGADKISLNNAAITTPELITETAHIF 120 Query: 121 GVQCIVVGIDTWYDAETGK-YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G QC+V+ ID + T K + + Y S ++ E + + + GAGEI++N + Sbjct: 121 GGQCVVISIDGIH---TNKGFRIYDYL-THSALDISPSE---FAKRAEDSGAGEILINSV 173 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 ++DG G+D E + V V ++P+I GGA F+E F Sbjct: 174 DRDGSYLGFDHELINSVCSVVNIPVIVCGGAKNAGDFIEVF 214 >UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC778 Length = 164 Score = 110 bits (276), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 61/131 (46%), Positives = 83/131 (63%), Gaps = 1/131 (0%) Query: 19 KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFC 78 KG +F++ + L K Y++ GADELVFYDITAS++ R +V++VAE I+IPFC Sbjct: 11 KGKKFKDIVDVDSPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENINIPFC 70 Query: 79 VAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETG 138 V GG+ LED IL GADK+SINS A+ +P LI + +FG QC+V+ ID + E G Sbjct: 71 VGGGVNKLEDFTDILRKGADKVSINSSAVKNPELIREASLKFGAQCVVLSIDAKKN-EEG 129 Query: 139 KYHVNQYTGDE 149 + V G E Sbjct: 130 SWSVYVKGGRE 140 >UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase subunit n=1 Tax=Erythrobacter litoralis HTCC2594 RepID=Q2N6D2_ERYLH Length = 264 Score = 108 bits (270), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 68/214 (31%), Positives = 112/214 (52%), Gaps = 6/214 (2%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 RIIP L + VK QF+ IGDIV A+ + + ADEL+ DI D Sbjct: 5 RIIPVLLLDGTSAVKTHQFKPARYIGDIVNAAQIFNSKMADELIVVDIGYHQDN-PSRPE 63 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 + +AE +P GGI S+++AA + G +K+SIN+ + L+ A +FG Q Sbjct: 64 VIRHLAEECFMPLAFGGGISSVDEAAALFKDGIEKVSINTAFVEGGALVEEAARQFGSQS 123 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 +V ID +A+ G Y V G TR + ++ + + +GAGEI++ +++DG+ Sbjct: 124 VVASIDARREAD-GSYQVYSRGG----TRALGIDPVEMARRAEAQGAGEILIQSIDRDGM 178 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 R GYD ++ + + +P++A GGA T++ + Sbjct: 179 RKGYDRNLVRSIVDATTLPVVALGGADTVDDLAQ 212 >UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=Lactobacillus fermentum RepID=C0WXE8_LACFE Length = 188 Score = 106 bits (264), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 59/192 (30%), Positives = 104/192 (54%), Gaps = 7/192 (3%) Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 V +++ + +P V ++++ + +L GADK+ I++ ++ P I ++A FG Q Sbjct: 4 MVEAISQQVFMPMTVVCNVRTVVEVRNLLLAGADKVGISTRSIMAPDFIPKVAQVFGNQS 63 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 IV +D D T + V G+ T+ + +W V + G GE+++N M++DG Sbjct: 64 IVAILDYHVDPRTNRKIVCT-PGN------TELDAYEWTLRVVELGVGELLVNSMDRDGT 116 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 NG+D + + +P++ASGGAG+ F E F ++ V GA+AAS FH + I E+ Sbjct: 117 ENGFDTAFYRDLTTTLTIPVVASGGAGSTVDFEEVFVNSGVTGAMAASAFHLDQMTISEV 176 Query: 245 KAYLATQGVEIR 256 K L +G+ +R Sbjct: 177 KETLLEKGILVR 188 >UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PRW0_MALGO Length = 576 Score = 105 bits (263), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 104/379 (27%), Positives = 160/379 (42%), Gaps = 125/379 (32%) Query: 1 MLAKRIIPCLDVR-------------------------------DGQVVKG--VQFRNHE 27 M +RI+ CLDVR DG + G Q RN Sbjct: 200 MPTRRIVACLDVRSNDDGDLVVTKGESYNVRERQPAEGQAKSTADGTIRSGGKAQVRN-- 257 Query: 28 IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRV---AEVIDIPFCVAGGIK 84 +G V LA+RY EEGADE+ F +IT+ + + D+ +S + A I +P V GGI+ Sbjct: 258 -MGKPVELAQRYYEEGADEIAFLNITSFRNWALGDQPMLSLLNVAAATIFVPLTVGGGIR 316 Query: 85 -----------SLEDAAKILSFGADKISINSPAL-----------------ADP------ 110 +LE A GADK+SI S A+ DP Sbjct: 317 DFTDPDGTFHPALEVAHAYFRAGADKVSIGSEAVYAVEQLLQRATELGDCTGDPCAAPAM 376 Query: 111 -----TLITRLADRFGVQCIVVGIDT----------------------WYDAETGKYHVN 143 T I ++A ++GVQ +VV +D DA T + + Sbjct: 377 ALRGDTGIEQIAHKYGVQAVVVSVDPKRVYLSDQEIDGLSDEHSSGDGPVDARTHPHASS 436 Query: 144 QYTGDESRTRVT----QW------------ETLDWVQ---EVQKRGAGEIVLNMMNQDGV 184 G + R +W +D VQ V++ GAGE+++N +++DG Sbjct: 437 IVCGQDERPETAGQSARWWYMCTVKGGRESRDIDVVQLARGVERLGAGELLINSIDRDGS 496 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE------AFRDADVDGALAASVFHKQI 238 G+D + + VR ++P+IAS GAG +HF + A R A ++ ALAA +FH++ Sbjct: 497 YAGFDEKLIDLVRGCVNIPVIASSGAGCADHFCDVLASRPAARGAPIEAALAAGIFHRRE 556 Query: 239 INIGELKAYLATQGVEIRI 257 ++I ++K A G +R+ Sbjct: 557 VSIMDVKKRCADAGYPVRM 575 >UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlorococcus marinus clone ASNC1363 RepID=Q1PLA2_PROMA Length = 268 Score = 103 bits (258), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 76/226 (33%), Positives = 115/226 (50%), Gaps = 20/226 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGA----DELVFYDITASSDGR 59 KRII L + V FR + IGD+ L K Y + DEL+ D+T GR Sbjct: 5 KRIIFTLLYNSNRFVLSRNFR-LQTIGDLDWLKKNYNFDNVAYHIDELLILDVTR---GR 60 Query: 60 VVDKSW---VSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + + V++++E I +P + GGI SLE A GADK+SINS +L D +L+T++ Sbjct: 61 KDSEEFCKVVTQISENIFVPLTIGGGINSLEKAKLFFKSGADKVSINS-SLLDESLVTQI 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQW-ETLDWVQEVQKRGAGEIV 175 +G QC+V ID E +Y+V G + + + ++ E ++ + GEI Sbjct: 120 VKNYGKQCLVGSIDVLKKNE--EYYVYSNNGTKLVSSLNKFFENKEFFNNI-----GEIY 172 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR 221 +N +NQDG NG D+ + V VP I SGG G + +AF+ Sbjct: 173 INSINQDGTGNGLDISLAEFVSAKSEVPFIISGGVGKITDIKDAFK 218 >UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Euryarchaeota RepID=HIS4_METBU Length = 246 Score = 103 bits (257), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 68/248 (27%), Positives = 127/248 (51%), Gaps = 17/248 (6%) Query: 2 LAKRIIPCLDVRDG---QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +IP +D++ G Q+V+GV + D V +A + +GA L D+ + +G Sbjct: 1 MSFEVIPAVDMKGGKCVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIEG 60 Query: 59 RVVDKSWVSRVAEVID---IPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + + ++ E I V GGI+S EDAA +L G DK+ +++ AL DP LI + Sbjct: 61 NRTNAPIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLLDIGIDKVILSTAALKDPELIKK 120 Query: 116 LADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIV 175 L+D FG + I V +D+ + GK + +T + T V + + +++GAG I+ Sbjct: 121 LSDEFGSEHINVALDS----KNGKISIEGWTKESEHTAV------EMGSQFEEKGAGSIL 170 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 ++ +G+ NG + + +++ +P+IASGG T+E + ++ G + S + Sbjct: 171 FTNIDSEGLLNGVNPKPTEELVNAVTIPVIASGGVTTLEDIV-TLKNTGAAGVVVGSALY 229 Query: 236 KQIINIGE 243 K+ + E Sbjct: 230 KKRFTLTE 237 >UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. BL107 RepID=Q062W6_9SYNE Length = 255 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 74/261 (28%), Positives = 122/261 (46%), Gaps = 11/261 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRY----AEEGADELVFYDITASS 56 M KR+I L + G FR +I G++ L Y DELV D++ Sbjct: 1 MAKKRLIFTLLYQKGGFYLSRNFRLQKI-GNLSWLKINYNFYSVACAIDELVILDVSREK 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 R V+ V + +P + G I SL+DA ++ GADK+ IN+ +P L+ L Sbjct: 60 PDRQEFCEVVNEVCQNCFMPLALGGHINSLDDAKMLIYNGADKLIINTALHENPNLVREL 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 +G QCI+ +D Y E G + V G + R + ++ + + G GE+ L Sbjct: 120 IAIYGSQCIIGSVD--YKIEEGSFIVYTNQGKKRLDRPLN----EHIERLGEMGVGELYL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 N +++DG GY E LK++ H+P+I +GGAG H E+ VD A++ + Sbjct: 174 NSIDRDGTGQGYVSEVLKQLDSASHLPIIQAGGAGNKHHLQESLECRGVDAVATANLLNF 233 Query: 237 QIINIGELKAYLATQGVEIRI 257 + + + +L +G+ + I Sbjct: 234 VGDGLPKAREFLINKGISMAI 254 >UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. AS9601 RepID=A2BSD9_PROMS Length = 254 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 60/231 (25%), Positives = 121/231 (52%), Gaps = 5/231 (2%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV-VDK 63 R+I L + +++K +F+N++ +GD + + + + + DE+ + +D Sbjct: 6 RVILSLIIDSKRMIKRSKFKNYKYLGDPLNIIRIFNSKRVDEISIISCENYEKKDINIDF 65 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ +++ P +GG++SLEDA K+ S G +KI I + +P +I ++A+++G Q Sbjct: 66 EFLEKISGEAFCPLTYSGGVRSLEDADKLFSIGFEKIGIRNLLHTNPEVIKQIAEKYGSQ 125 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 +V+ ID E + YT S + T+ L++++ + GAGE+VL + ++G Sbjct: 126 SVVIFIDY---KELNNNEIEIYTSYNSFFKSTKSSILEFIKNAESYGAGEVVLQSILREG 182 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 G DL+ +K++ +P+I+S G + +AF DG +A+ F Sbjct: 183 QSKGLDLDIIKEITNKTILPIISSCGMRDLSDARKAF-SLGADGVMASKFF 232 >UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001910D6A Length = 157 Score = 100 bits (248), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 48/55 (87%), Positives = 50/55 (90%) Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 DGVRNGYDL QLKKVR+VC VPLIASGGAGTMEHFLEAFRDADVDGALAA F + Sbjct: 1 DGVRNGYDLTQLKKVRDVCRVPLIASGGAGTMEHFLEAFRDADVDGALAAFRFSQ 55 >UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LAC8_MAGSM Length = 260 Score = 99.8 bits (247), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 69/214 (32%), Positives = 117/214 (54%), Gaps = 7/214 (3%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 R+IP L +++G++VK V+F + +GD V AK + ++ DEL DI+AS G D Sbjct: 5 RVIPTLLLKEGRLVKTVRFNQAKATYVGDPVNTAKIFNDKEVDELAVLDISASRRGAEPD 64 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V ++A +P GG+++L+ ++ G +K+ +N+ + L+ +G Sbjct: 65 FECVEQLASECFMPLLYGGGVRNLQQIQRLFHSGVEKVMLNTAFFSGSGLLQEAVKIYGS 124 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q + V ID D G+Y V G R T + + Q+ ++ GAGE++LN M+QD Sbjct: 125 QSLGVSIDVKKDL-WGRYRVMSQGGQ----RKTGLDPVVAAQQAEQAGAGELLLNAMDQD 179 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF 216 G++ GYDLE +++V +P+IA GGA ++ F Sbjct: 180 GMQQGYDLELVQRVSRGVAIPVIAVGGAASVADF 213 >UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Bacteria RepID=HIS4_LISW6 Length = 240 Score = 99.0 bits (245), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 70/243 (28%), Positives = 119/243 (48%), Gaps = 15/243 (6%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +I P +D+++GQ V+ Q F I+ D + AK +A GA L D+ + +GR V Sbjct: 2 QIFPAIDLKNGQCVRLFQGDFSKKMIVNEDPIAQAKAFATGGATYLHIVDLDGALEGRPV 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + ++ E +P V GGI+SL L G D++ I S AL +P + ++G Sbjct: 62 NLEIIQKMKEAATVPVQVGGGIRSLAQVDYYLDSGIDRVIIGSAALTNPDFLHAAVQKYG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I VGID N Y V+Q LD ++++K G I+ +++ Sbjct: 122 PK-IAVGIDAK----------NGYVATSGWLEVSQVNYLDLAKQMEKVGVETIIYTDISR 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G +LEQ+ +++ ++ LIASGG + LEA + GA+A + I++ Sbjct: 171 DGTLTGPNLEQMAALQKHVNIHLIASGGVSSRAD-LEALSQLGLYGAIAGKALYNGHISM 229 Query: 242 GEL 244 ++ Sbjct: 230 SDV 232 >UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TGW8_METVO Length = 181 Score = 96.7 bits (239), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 51/145 (35%), Positives = 83/145 (57%), Gaps = 5/145 (3%) Query: 77 FCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAE 136 F GGIK+ E+A+KI G +KIS+NS P+L+T L+ +G Q IV +D + Sbjct: 9 FASGGGIKTFEEASKIFELGFEKISLNSVLFEKPSLLTELSQSYGSQSIVASVDVKKNL- 67 Query: 137 TGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKV 196 GK V Y G S+ + LD+V+ ++ GAGE+++N ++ +G GY+L + ++ Sbjct: 68 FGKLKV--YNG--SKNNSINDKILDYVKNLENLGAGELLINSVDLEGTYKGYNLSLINEL 123 Query: 197 REVCHVPLIASGGAGTMEHFLEAFR 221 +PLIA GGA + + F +A + Sbjct: 124 SNALTIPLIALGGASSTKDFKDALQ 148 >UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=6 Tax=Euryarchaeota RepID=D2RTG3_9EURY Length = 244 Score = 96.3 bits (238), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 64/246 (26%), Positives = 125/246 (50%), Gaps = 14/246 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++IP +D++DG+VV+ VQ + GD V A+R+ +EGA+ L D+ + +G+ + Sbjct: 8 QVIPAVDMQDGEVVQLVQGERGTEKTYGDPVDAARRWLDEGAEALHLVDLDGAFEGQRAN 67 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V E +D+P + GGI++ +DA +L G D++ + + A+ +P ++ +++R Sbjct: 68 GDAIDEVLETVDVPTQLGGGIRTADDAVDLLERGVDRVILGTAAVENPDIVAEISERHPD 127 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +V DA+ G+ V +T + V D + + GA I+ ++ + Sbjct: 128 SVVV-----SLDAKDGEVVVEGWTEGAGISPV------DAAERYAELGAAAILFTNVDVE 176 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G E ++++ E VP+IASGG T+E + A DA + S ++ + Sbjct: 177 GKLEGVAAEPVRELVEATDVPVIASGGVATLED-VRALEDAGAAAVVVGSALYEGKFTLA 235 Query: 243 ELKAYL 248 E ++ + Sbjct: 236 EAQSAI 241 >UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=91 Tax=Bacteria RepID=HIS4_SYNJB Length = 261 Score = 95.5 bits (236), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/241 (28%), Positives = 118/241 (48%), Gaps = 14/241 (5%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ G+ V+ G + ++ D + A+ +A +GA L D+ + G V+ Sbjct: 10 VIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVN 69 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+ + IP V GGI+SLE A ++L G D++ + + A+ DP + + F Sbjct: 70 LPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPG 129 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + VGI DA G+ + T + VQ VQ +GA I+ +++D Sbjct: 130 R-VWVGI----DARQGQVATRGW------LSTTPLRAPELVQRVQAQGAAGIIYTDISRD 178 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G +LEQL+++ V VP+IASGG G++ L + GA+ + I++ Sbjct: 179 GTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQ 238 Query: 243 E 243 E Sbjct: 239 E 239 >UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit HisF2 n=3 Tax=Rhizobium RepID=Q7WYR2_RHIL3 Length = 251 Score = 94.4 bits (233), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 104/220 (47%), Gaps = 11/220 (5%) Query: 2 LAKRIIPCLDV-RDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + KR+IP L V + ++VK ++F +GD + + + E+ DE+ DI A+ GR Sbjct: 1 MRKRLIPVLLVDQKRRLVKTIEFGERTYVGDPFNVVRLFNEKEVDEICILDIDATRTGRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D +V +A +P GGI L+ ++ G +K + A + L+ +A Sbjct: 61 PDLGFVRELATECFMPLAYGGGITELKQCEELNRSGVEKFVLGQGA-RNSQLVGAIAADM 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V +D D +G + E +++ +Q G GEI+L Sbjct: 120 GSQALVACVDV--DGRGAAASCYASSG-------ARQEPIEFCLRLQDAGVGEIILQSKT 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 DG RNGYDLE ++ + +P++A GGAG + H +E Sbjct: 171 LDGTRNGYDLELIQSITRKLSIPVVALGGAGDVAHLMEGL 210 >UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PWX6_9BACT Length = 243 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/243 (26%), Positives = 119/243 (48%), Gaps = 15/243 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++ G+ V+ Q + E D V +AK + ++GA L D+ + DG + Sbjct: 3 IFPAIDLKGGKCVRLTQGKKDEETVFSDDPVDMAKSWEDQGAQYLHVVDLDGAFDGLPKN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S V ++ I+IP GG+++ E +L G +++ I + AL P+ + L F Sbjct: 63 LSIVEQIVNNINIPIEFGGGLRTTESVKSVLDLGVERVIIGTKALDSPSWVEELCSLFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + VGI DA+ GK V+ +T +T + D+ +E++K I+ +++D Sbjct: 123 R-VAVGI----DAKNGKVAVHGWTSLSEKTAI------DFAREMEKFSPCAIIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G ++E LK++ P+IASGG +++ +E V+G + + I Sbjct: 172 GMLQGPNIESLKELLSSIKTPVIASGGISSLKD-IEYICQLPVEGMIVGKALYTGHIKFS 230 Query: 243 ELK 245 E K Sbjct: 231 EAK 233 >UniRef50_Q1NTJ9 Histidine biosynthesis n=1 Tax=delta proteobacterium MLMS-1 RepID=Q1NTJ9_9DELT Length = 186 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 42/91 (46%), Positives = 63/91 (69%) Query: 167 QKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD 226 ++ GAGEI+LN +++DG +G+DLE +K V+E +P+IAS GAG EHF E F D Sbjct: 94 EELGAGEILLNCIDKDGTNSGFDLELVKMVKEAVTIPVIASSGAGKPEHFSEVFTVTGAD 153 Query: 227 GALAASVFHKQIINIGELKAYLATQGVEIRI 257 ALAA +FH++ + I E+K +L G+E+R+ Sbjct: 154 AALAAGIFHRREVAISEVKEHLQRHGIEVRL 184 >UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DY29_METI4 Length = 248 Score = 91.7 bits (226), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 61/244 (25%), Positives = 119/244 (48%), Gaps = 13/244 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ +D+ GQVV+ Q + E+ D V A + +GAD L D+ + G Sbjct: 10 KMYAAIDLFKGQVVRLRQGKLEEMTVYGSDPVKTALFWQSQGADGLHIVDLEGAFSGTPR 69 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++A + IP GG++++E K L GA ++ I S + DP + L+++ G Sbjct: 70 HLDLLEKIAYAVTIPIQFGGGLRTVEQVLKALEGGAQRVVIGSKLVTDPGFLQELSEKIG 129 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + IV +DT + G+ + E + + + ++++ V+++GAG ++ + Sbjct: 130 PEKIVAALDT----QNGEIQI------EGWKKSSGYSLENFIKWVEQKGAGFLLYTNIQT 179 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G D+ +KV E+ +P+ ASGG G + E + + GA+ ++ I++ Sbjct: 180 DGTLKGADVRGTQKVVEMSRLPVFASGGIGCTKDVEELLKLKGLYGAILGRSLYEGKISL 239 Query: 242 GELK 245 E+K Sbjct: 240 SEIK 243 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 91.3 bits (225), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 66/242 (27%), Positives = 121/242 (50%), Gaps = 14/242 (5%) Query: 5 RIIPCLDVRDGQVVKGVQ-FRNHEIIGDIVP--LAKRYAEEGADELVFYDITASSDGRVV 61 R+ P +DV+DGQ V+ + N + P +AK + E GA + D+ + G V Sbjct: 2 RLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGV 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + ++ +++P + GGI++LE+ ++L G ++ I + A+ +P I DRFG Sbjct: 62 NAETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + IVVG+ DA+ G + E +V+ L ++ G IV +++ Sbjct: 122 AEHIVVGV----DAKDGLVAI------EGWEKVSDKTALSLALAMKDIGVQTIVYTDISK 171 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG+ G ++EQ K + + + +IASGG M+ L DA + GA+ +++ I++ Sbjct: 172 DGMLAGPNVEQTKILSDKTGIDIIASGGMSCMDD-LTHINDAGIHGAIIGKAIYEKRIDL 230 Query: 242 GE 243 E Sbjct: 231 KE 232 >UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Firmicutes RepID=HIS4_CLOBA Length = 237 Score = 89.7 bits (221), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 123/241 (51%), Gaps = 15/241 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+ DGQ V+ Q + E++ DI +AK + GA+ + D+ + G V+ Sbjct: 3 ILPAIDIIDGQAVRLYQGDYNKKEVVANDIFNIAKEFECLGAEYIHLVDLDGAKSGYCVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++A+ +D+P V GGI++ E K++ G ++ + + A+ D L+ + + +G Sbjct: 63 EKIILKLAQTVDVPIEVGGGIRNFETIEKLIENGISRVILGTIAMEDEGLLKKAIECYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I VGID N Y ++ LD+ + ++ G I++ +++D Sbjct: 122 EKISVGIDCK----------NGYVYGRGWLAESKLNYLDFAKNMESLGVKSIIVTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G + + L K++++ ++ + ASGG +E+ E ++ D+ GA+ + +++ Sbjct: 172 GTLEGPNFDMLMKLKKLVNIDITASGGIRDIENIKE-LKNIDIYGAITGKAIYSGNLSLK 230 Query: 243 E 243 E Sbjct: 231 E 231 >UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Halothermothrix orenii H 168 RepID=HIS4_HALOH Length = 237 Score = 89.0 bits (219), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 103/216 (47%), Gaps = 13/216 (6%) Query: 6 IIPCLDVRDGQVV--KGVQFRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++DG V K F + V +A + + GA L D+ + G Sbjct: 3 VIPAVDIKDGSCVRLKKGDFNKRRVYSTSPVDVALYWEKHGASRLHIVDLDGAKSGWPTH 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A ++IP V GGI+SL+ K L G D+I + + AL +P L+ R D FG Sbjct: 63 LKTIREIALRVNIPLQVGGGIRSLKVIKKYLDSGVDRIILGTVALKNPELVKRALDNFGS 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IVVG+ DA GK E + +Q D + E+++ G + +N+D Sbjct: 123 NRIVVGV----DARGGK------VATEGWLKTSQVTVEDIISEMEEVGVKTFIYTDINRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 G+ G D+E +K+V + +IASGG + + + Sbjct: 173 GMLKGPDIEGIKRVLKSTKARIIASGGISSRQDLIN 208 >UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Cyanobacteria RepID=HIS4_PROMS Length = 255 Score = 88.2 bits (217), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 62/251 (24%), Positives = 123/251 (49%), Gaps = 16/251 (6%) Query: 6 IIPCLDVRDGQVV---KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ +G+ V KG + + + A+ + EGA + D+ A+ G + Sbjct: 3 LIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSPTN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++A+ ++IP + GGI+S E ++ S+G +K+ + + A+ + L+ L+++F Sbjct: 63 DKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I+VGI DA+ GK + ++S T D V+E ++ +N D Sbjct: 123 R-IIVGI----DAKDGKVSTRGWL-EQSNIFAT-----DLVKEFSSFKIASFIVTDINTD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE--AFRDADVDGALAASVFHKQIIN 240 G G + E +K + E+ +P+IASGG G++ L F ++ + G + ++ Sbjct: 172 GTLEGTNEEFIKSILEITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFT 231 Query: 241 IGELKAYLATQ 251 I E L+ + Sbjct: 232 INEANNVLSAE 242 >UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Methanocaldococcus RepID=C9RH20_METVM Length = 237 Score = 87.4 bits (215), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 125/240 (52%), Gaps = 18/240 (7%) Query: 6 IIPCLDVRDG---QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD-GRVV 61 +IP +D++D Q+++G + H + D V +AK++ +GA+ L D+ A+ G V Sbjct: 3 VIPAVDLKDKKCVQLIQGDPTKKHLELEDPVNVAKKWVHDGAEYLHIVDLDAALGCGNNV 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 D + ++ E ++IP V GGI+SL A +++ G DKI + + A+ DPT + L Sbjct: 63 D--VIEKIVEEVNIPVEVGGGIRSLTIAKRLMDIGVDKIVVGTKAITDPTFLNELLSEIE 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I++ + + + GK + + ++ + + + ++ G I+ ++ Sbjct: 121 REKIILAV----ECKQGKVAIKGWKETINKNPIE-------IAKKYEKKVGGILFTNVDV 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 +G+ +G + ++ + + VP+I SGG T+E ++ ++ VDG + S +K IIN+ Sbjct: 170 EGMLSGIKTDIIETLVKNVRVPIIYSGGITTLED-IKKLKEIGVDGVIIGSALYKGIINL 228 >UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=HIS4_UNCTG Length = 244 Score = 86.7 bits (213), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 64/231 (27%), Positives = 120/231 (51%), Gaps = 15/231 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR-NHEII--GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+R G V+ Q + E I D V +AK + +GA L D+ + G ++ Sbjct: 3 IIPAVDIRQGNSVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTNIN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 K+ + + +DIP V GGI++++ ++ GA + + A +P ++ + R+G Sbjct: 63 KAIIKNICAAVDIPVEVGGGIRNMDKIKEVFDIGAAYAILGTVAFNNPEIVKKAITRYGS 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I+V + DA+ GK ++ + +T E + V ++++ G EI+ +++D Sbjct: 123 EKIIVAV----DAKDGKVAISGW------KDITPIEASELVNKLKEIGVQEILYTDISRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 G+ G D LKK+ E + +IASGG T+++ ++ + + DG AA V Sbjct: 173 GMFTGPDFAGLKKLSE-SGMRIIASGGVKTIDNLVK-LKKYEKDGVFAAIV 221 >UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Euryarchaeota RepID=HIS4_METJA Length = 237 Score = 86.3 bits (212), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 58/239 (24%), Positives = 130/239 (54%), Gaps = 16/239 (6%) Query: 6 IIPCLDVRDG---QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D++D Q+++G + H + + V +AK++ +EGA+ L D+ A+ G + Sbjct: 3 IIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAF-GTGNN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + + +++P V GGI++LE A +++S G D++ + + A+ +P I L G Sbjct: 62 RDVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIGK 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IV+ + + + GK + + +T ++ ++E + + G I+ ++ + Sbjct: 122 DKIVLAV----ECKEGKVVIKGWKEKVDKT------PIEVIKEFEDK-VGYILFTNVDVE 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G +++ +K++ E +P+I SGG T+E ++A ++ + G + S +K +I++ Sbjct: 171 GLLKGINVDIIKELIEKTDIPIIYSGGITTLED-IKALKELGIYGVVIGSALYKGLIDL 228 >UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9303 RepID=A2CB98_PROM3 Length = 266 Score = 85.1 bits (209), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 108/246 (43%), Gaps = 21/246 (8%) Query: 1 MLAKRIIPCL--DVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGA----DELVFYDITA 54 M KRII L D + + FR E+ GD L + Y DEL+ D++ Sbjct: 1 MPKKRIIFTLLYDSQSEHFLLSRNFRVQEV-GDYNWLKENYDFTNLSYYIDELLVIDVSR 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLIT 114 S + +++ +P GG+ SL+ A + GADK+ +N+ +P LI Sbjct: 60 KKRNSQRFCSMLKKLSSDCFLPIGAGGGLDSLDKAKMLFDSGADKLILNTSVYENPELIK 119 Query: 115 RLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETL----DWVQEVQKRG 170 L +G Q I+ +D + E G + + + G + + + ++ + +W+ Sbjct: 120 ALNKFYGQQAIIASVDIKKN-ELGIFDIYTHNGTKKASSLKDYQNIICKNEWI------- 171 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHV-PLIASGGAGTMEHFLEAFRDADVDGAL 229 GE+ LN M +DG GYD LK + P+I +GGAG H +E VD Sbjct: 172 -GELYLNSMERDGTGQGYDFNMLKSFTNLNKKHPIILAGGAGKTSHIVEGLLTDGVDACA 230 Query: 230 AASVFH 235 A +F+ Sbjct: 231 TAHLFN 236 >UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Synechococcus sp. WH 8102 RepID=HIS62_SYNPX Length = 269 Score = 85.1 bits (209), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 15/241 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRY----AEEGADELVFYDITASS 56 M KRII L DG F+ I GD L + Y + DEL+ DI+ S Sbjct: 1 MSKKRIIFVLLYCDGFFCLSRNFKLQRI-GDFRWLQRNYNFNYSATFIDELIILDISRKS 59 Query: 57 DGRVVDK--SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLIT 114 R ++K + + ++E I +P GGI+S EDA + GADK+ +N+ + P + Sbjct: 60 --RDINKFATLLYNLSENIFVPITAGGGIRSFEDAKVLFENGADKVCLNTSLIQCPHVSE 117 Query: 115 RLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEI 174 +++ +G Q +V ID +D K+ + D V Q+ + + + EI Sbjct: 118 KISSVYGQQSLVASIDFKHDHGDFKFFI-----DNGLIEV-QYNIQELISFLDPLPFCEI 171 Query: 175 VLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 +L +++DG G+DL R+ P+I GGAG +H +E D A + Sbjct: 172 LLQSVDRDGTGTGFDLTLANTFRDQLSKPIILLGGAGHSDHLVEGLLHQSTDAVATAHLL 231 Query: 235 H 235 + Sbjct: 232 N 232 >UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Chlorobiaceae RepID=HIS4_CHLT3 Length = 262 Score = 84.7 bits (208), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 109/207 (52%), Gaps = 13/207 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D++ G+ V+ + F +I + + +A + ++ A + D+ A+ G+ + Sbjct: 3 IIPAIDIKGGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALTGKPEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + +DIP + GGI++ EDAA+ L G ++ I S A+ +P+L+++L +++G Sbjct: 63 FDKIKQIVDTLDIPIEIGGGIRTAEDAARYLDIGVYRVVIGSAAVKNPSLVSQLIEKYGP 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IVVGI DAE G ++ + T +Q + + E++ RG I+ + +D Sbjct: 123 RKIVVGI----DAEDGIAKISGW------TESSQKKDYELALEMKDRGVERIIYTDITRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGG 209 G G E K E + + ASGG Sbjct: 173 GTLEGVGYETTKAFAEKAQMRITASGG 199 >UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Methanomicrobiales RepID=HIS4_METMJ Length = 239 Score = 84.7 bits (208), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 66/241 (27%), Positives = 117/241 (48%), Gaps = 16/241 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNH--EIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 I P +D+ DG+ V+ VQ R + GD A R+ +EGAD L ++ + GR Sbjct: 3 IYPAVDILDGRCVQLVQGRPEAATVYGDPAAWAHRWLDEGADGLHVVNLDGAF-GRARKN 61 Query: 64 SWVSRVAEVIDIPFC-VAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + R F + GGI+S+EDAA L G D++ +++ A+ +P +I LA+ FG Sbjct: 62 ADLIRAFTRETETFTELGGGIRSVEDAAGWLDAGVDRVIVSTQAVREPEMIRTLAEEFGG 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + ++ GI DA G+ + + L W + + GAG ++ ++ + Sbjct: 122 ERVMAGI----DARAGEVMIEGWERPAG-------SYLSWAERFESLGAGSLLYTNVDVE 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G++ G +E + ++ VP++ SGG + + A RDA GA+ S + + + Sbjct: 171 GLQQGIAIEPVTELLARVKVPVVVSGGISSPGD-VAALRDAGAAGAVLGSALYAGKVRLP 229 Query: 243 E 243 E Sbjct: 230 E 230 >UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=15 Tax=root RepID=HIS4_DEHSC Length = 244 Score = 84.7 bits (208), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/239 (25%), Positives = 114/239 (47%), Gaps = 15/239 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ G+ V+ Q + + D V A R+ GA L D+ ++DG+ V+ Sbjct: 10 IIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQSVN 69 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A IP V GGI+S+E K+L G D++ + + A+ +P L+ + R+ Sbjct: 70 FELIKEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICARYA- 128 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V I DA GK + + T+ + L+ + ++K G + +++D Sbjct: 129 DSVAVSI----DARNGKVATRGWVTN------TEIDALELARSMKKLGIRRFIYTDISRD 178 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G + + ++ + +VP+IASGG ++ H L +D +GA+ + +N+ Sbjct: 179 GTLSEPNFAAIRDLISAINVPVIASGGVSSLSH-LRLLKDIGAEGAIVGKAIYTGDLNL 236 >UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Thermus RepID=HIS4_THET2 Length = 235 Score = 84.3 bits (207), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 74/244 (30%), Positives = 116/244 (47%), Gaps = 20/244 (8%) Query: 5 RIIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+IP +D++ G+ V+ G R GD V A R+ EEGA L D+ + G Sbjct: 2 RLIPAVDLKSGKAVRLYEGDPARETPY-GDPVEAALRFQEEGATLLHLVDLD-RALGTGE 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 ++ V RVA + IPF +AGGI+SLE + LS GA + + + A+ DP L+ R+ + G Sbjct: 60 NREAVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVG 119 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V + DA + V+ + S + LD ++ + G ++ + + Sbjct: 120 PDRLAVAL----DARGLEVVVSGWQEAASAS------ALDLLRAWAEMGVRTLLYTDVRR 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTME--HFLEAFRDADVDGALAASVFHKQII 239 DG G D E + +VR LI GG + E H L+A VDGAL ++ I Sbjct: 170 DGTLLGLDREVVARVRAAWPHELIVGGGIASPEDLHLLQAL---GVDGALIGKALYEGRI 226 Query: 240 NIGE 243 + E Sbjct: 227 RLKE 230 >UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Thaumarchaeota RepID=HIS4_NITMS Length = 236 Score = 84.3 bits (207), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 117/237 (49%), Gaps = 15/237 (6%) Query: 5 RIIPCLDVRDGQVV---KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IIP +D+ DGQVV KG + D V +AK++ + GAD L D+ A+ G Sbjct: 2 KIIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDLDATI-GTGS 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + ++++ + IP VAGG+++ E + +SF ++++ I + A D ++ R+A ++ Sbjct: 61 NLDLIEKISKELSIPVEVAGGLRNEEIIDRAISF-SNRVVIGTMAFKDKEMLQRIAKKYD 119 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 IV+ +D H++ + T+ LD + E G E +L +++ Sbjct: 120 FSKIVISVD----------HIDGFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVSK 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 DG G DLE L+K V + +IASGG ++ + R L +++ +I Sbjct: 170 DGTLEGPDLEYLEKACAVQNANVIASGGISNIDDVSDVQRKNAFAVILGKALYENKI 226 >UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_DESHD Length = 250 Score = 84.3 bits (207), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 58/246 (23%), Positives = 127/246 (51%), Gaps = 18/246 (7%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHE--IIGD-IVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+ P +D+++G+ V+ +Q R + + G+ V +A+++ E+GAD L D+ + G+ V Sbjct: 4 RLFPAIDLKEGKAVRLLQGRMEDATVYGEQPVEVARKFKEQGADSLHVVDLDGAFAGKPV 63 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + ++ + + V GGI++LE ++L G +++ + + A+ +P L+ + RF Sbjct: 64 NDAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQRFE 123 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +V+GI DA+ G V + T+ + LD ++K G +V +++ Sbjct: 124 -EAVVIGI----DAKDGLVAVQGW------AEKTEIKALDLALRMKKVGVKHLVFTDISR 172 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL----EAFRDADVDGALAASVFHKQ 237 DG+ G +++ ++ + + ++ASGG +E EA R ++GA+ + Sbjct: 173 DGMLQGPNIQSTVELARLSGLQVVASGGVSRLEDLRLLQEEANRGVSLEGAIVGKALYAG 232 Query: 238 IINIGE 243 ++ E Sbjct: 233 AFSLAE 238 >UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Clostridia RepID=HIS4_SYNWW Length = 244 Score = 83.6 bits (205), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 119/229 (51%), Gaps = 14/229 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDI-VPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DGQ V+ VQ R N + D +A+ + E+GA L D+ + G + Sbjct: 3 IYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSPQN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A IDI F V GG++ L D K+L+ GA ++ I + A++ P I L D+FG Sbjct: 63 LKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKFGP 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+G+ DA+ G V + S + +D+ +++ G + +++D Sbjct: 123 ERIVLGL----DAKEGMVAVEGWVSTSSVS------AIDFGLQMKALGIQTAIYTDVSRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 G+ G +L +K++ + +IASGG ++++ + A ++ + DG A Sbjct: 173 GLLQGPNLAAIKEMASSTGLDIIASGGVSSLDN-IRALKELENDGVSGA 220 >UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_THEYD Length = 244 Score = 83.2 bits (204), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/253 (25%), Positives = 122/253 (48%), Gaps = 14/253 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IIP +D++DG+ V+ Q + E+ + A R+ EGA+ L D+ + +G++ Sbjct: 2 QIIPAIDLKDGKCVRLRQGKFSEVTVYYDNPEDAALRWQNEGAEVLHVVDLDGAKEGKIG 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + ++ E V GGI+ +ED +LS G D++ + + A+ P + + RF Sbjct: 62 NLPSIKKIREAFRGNIEVGGGIRRIEDIELLLSVGIDRVIVGTIAVQSPDFVKEVCKRFP 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I+VGI DA+ G V + VT+ ++ ++Q G I+ +++ Sbjct: 122 -KKIIVGI----DAKDGLVAVKGW------VEVTEIRAIELALKMQDYGIWGIIYTDISR 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG+ G ++E K + E VP+IASGG ++E + + G + + I++ Sbjct: 171 DGMLTGPNIEATKALVESVKVPVIASGGVSSIEDIRKLAEIPQLWGVITGKAIYSGAIDL 230 Query: 242 GELKAYLATQGVE 254 E + GV+ Sbjct: 231 KEALRIIKGDGVK 243 >UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=31 Tax=cellular organisms RepID=HIS4_CHRSD Length = 249 Score = 82.0 bits (201), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 66/257 (25%), Positives = 119/257 (46%), Gaps = 23/257 (8%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++DGQ V+ Q R + D V +A R+ E GA L D+ + +G+ V+ Sbjct: 3 VIPAIDLKDGQCVRLKQGRMDDSTTYGDDPVAMAARWVETGARRLHLVDLNGAFEGKPVN 62 Query: 63 KSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+ +A D+P + GGI++ E L G + I + A+ +P + + RF Sbjct: 63 AEAVTAIARAYPDLPIQIGGGIRTAETIEAYLEAGVSYVIIGTQAVKEPAFVGEMCRRFP 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 ++VG+D + Y + V+ + +D + G IV + + Sbjct: 123 GH-VIVGLDAR----------DGYVATDGWAEVSTLKAVDLAKRFADDGVSSIVYTDIAR 171 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGA---GTMEHFLEAFRDADVDGALAASVFHKQI 238 DG+ G ++ ++ +P+IASGG G +E LE DA + GA+ ++ Sbjct: 172 DGMMQGVNIAATAELAREGGLPVIASGGVTHLGDIEALLE-VADAGILGAITGRAIYEGK 230 Query: 239 INIGELK----AYLATQ 251 +++ E + A LAT+ Sbjct: 231 LDVAEAQRLCDAQLATR 247 >UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Bacilli RepID=HIS4_STRSV Length = 242 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/248 (23%), Positives = 121/248 (48%), Gaps = 15/248 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +I+P +D++DGQ V+ + F ++ D++ A+ + E G + D+ + +G Sbjct: 1 MSMKILPAIDIKDGQAVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALEG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R ++ ++++ + V GGI+SLE L+ G D++ I S A+ +P + + Sbjct: 61 RAANRDLIAQIKAETGLAIQVGGGIRSLEQIEDYLAVGIDRVIIGSMAVKNPEFVEAALE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 RFG IV+GI DA+ G E + + + ++K G V Sbjct: 121 RFGSGKIVIGI----DAKEG------LVATEGWLETSNQDYISLALAMEKIGVRLFVYTD 170 Query: 179 MNQDGVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +++DG G +++ +K + + H +IASGG + + LE + + GA+ ++ Sbjct: 171 VDRDGTLTGPNIQHYQKLLASLKHAQVIASGGIQSADD-LEEMKKLGLAGAIVGKAYYSG 229 Query: 238 IINIGELK 245 I++ ++K Sbjct: 230 RISLEQIK 237 >UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_CLOK1 Length = 238 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/239 (23%), Positives = 123/239 (51%), Gaps = 15/239 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D++ G+ V+ + + E++ D A ++ EGA L D+ + G + Sbjct: 3 ILPAIDLKGGKCVRLYKGDMNSQEVVARDPFETALKFKSEGAQYLHMVDLDGALKGSGEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S++ + +D+P V GGI+++E K + G ++ + + AL + L+ + + + Sbjct: 63 LDIISKIVKNVDVPIEVGGGIRNIETIDKFIKLGVSRVILGTAALKNKELVIKAVENYD- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I VGI DA+ G + + T +++ +D+ +E++K G ++ +++D Sbjct: 122 EKIAVGI----DAKDGVPAADGW------TTLSKTNYIDFGKEMEKIGVQTLIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G +LEQL K++ +IASGG +E +++ + +V GA+ + + +++ Sbjct: 172 GTLEGTNLEQLLKLKNSVKCNVIASGGIKDIED-IKSLKKENVYGAIVGKAIYAKTLSL 229 >UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Chlorobiaceae RepID=HIS4_PROA2 Length = 261 Score = 81.3 bits (199), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 62/236 (26%), Positives = 109/236 (46%), Gaps = 15/236 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D++DG+ V+ + F +I + + +A + ++ A L D+ A+ G +V+ Sbjct: 3 IIPAIDIKDGKCVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGTMVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +DIP V GGI+S ED + L G ++ I S A+ +P LI L F Sbjct: 63 FEKIREIVATLDIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELLATFSP 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IVVGI DAE G + +T S + + E++K G I+ +++D Sbjct: 123 SQIVVGI----DAENGIPKIKGWTESSS------MQDYELALEMKKLGVKRIIYTDISRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHK 236 G+ G E ++ + + ASGG + + L+ VD + ++ Sbjct: 173 GMMQGVGYESTRRFAMKAGMRVTASGGVTSSDDLKKLQTLEQYGVDSVIVGKALYE 228 >UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW7_9FIRM Length = 243 Score = 81.3 bits (199), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 125/254 (49%), Gaps = 20/254 (7%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGDIVP-LAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+R G+ V+ ++ F + D +AK++ +GA L D+ + GR + Sbjct: 3 IFPAIDIRGGKCVRLLKGDFAKETVFSDKPEEMAKKWQTQGAQFLHLVDLDGALAGRPQN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + +DIP + GGI++LE ++L+ G ++ + S A+ DP L+ ++G Sbjct: 63 LATVKAILAAVDIPVELGGGIRTLESIDEVLALGVRRVILGSVAVRDPELVKTACAKYGD 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQY--TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + IVVGI DA+ G V+ + +GD T + +E++K G I+ ++ Sbjct: 123 R-IVVGI----DAKDGIVAVDGWGVSGDVEATALA--------KEMKKAGVKTIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQI 238 +DG G ++E K+ V ++ASGG ++ L+ + A ++G + + Sbjct: 170 RDGTLAGVNVEATAKLARESGVAVVASGGVKSIADIEALKPYEKAGIEGVIVGKSIYMGT 229 Query: 239 INIGELKAYLATQG 252 +++ E A +G Sbjct: 230 LDLAEAIEIAAKEG 243 >UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3165B Length = 246 Score = 80.5 bits (197), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 59/244 (24%), Positives = 116/244 (47%), Gaps = 18/244 (7%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPL--AKRYAEEGADELVFYDITASSDGRVV 61 + P +D+R G V+ Q F + E + D PL A+ + E GA L D+ + DGR Sbjct: 3 LYPAIDIRGGSAVRLRQGDFAD-ETVYDADPLSAARAWVEGGARWLHVVDLDGARDGRPA 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + R+A + +P GG++S + GA+++ + + A AD + + +G Sbjct: 62 NLEHLRRIAGELGVPVEFGGGLRSRASVDAAIEAGAERVILGTAAFADVDFLDDVVAAYG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +V D GK + T+ E + +Q+RG ++V + + + Sbjct: 122 ERVVVS-----VDVRGGKVASAGWK------EQTEMEAAAVIDHLQRRGVRKLVYSNIER 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQII 239 DG+ G DL+++++V E I SGG G+++H L + R +++G + +++ Sbjct: 171 DGMLTGPDLDEVRRVAESVRGSFIYSGGIGSLDHLAALASLRQVNLNGVIVGKALYERKF 230 Query: 240 NIGE 243 +G+ Sbjct: 231 TVGD 234 >UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9301 RepID=A3PE78_PROM0 Length = 222 Score = 79.7 bits (195), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 105/201 (52%), Gaps = 24/201 (11%) Query: 32 IVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAK 91 I+ L+++ EE + F DI+ ++ K++ +P + G I+S+E+A + Sbjct: 19 IINLSEKNWEEAYNNKFFNDISL-----LLSKTF---------LPITIGGKIRSIENAKE 64 Query: 92 ILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESR 151 + +FGADKI I+ D L+ + D +GVQ IVV +D + Y + + S Sbjct: 65 LFNFGADKILISRAFFQDQNLLKEIRDLYGVQSIVVQ----FDINSQNYDI---FINSSL 117 Query: 152 TRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAG 211 +V+ + + + +K GE+++N +++DG G++ E L + ++ ++PLIASGG G Sbjct: 118 EKVSNLKKIVYSLN-EKNLMGELIINQIDRDGTGFGHNTEYLNAIPKL-NMPLIASGGFG 175 Query: 212 TMEHFLEAFRDADVDGALAAS 232 + H E + D A+A S Sbjct: 176 SSIHMAECLK-FDSISAVATS 195 >UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=root RepID=HIS4_PELUB Length = 239 Score = 79.7 bits (195), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 55/243 (22%), Positives = 119/243 (48%), Gaps = 14/243 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFR-NHEIIGDIVPL--AKRYAEEGADELVFYDITASSDGRVV 61 +I P +D++D + V+ ++ N++ +I P+ A +Y + G L D+ + G V Sbjct: 2 KIFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGETV 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + D+ V GG++S++ K ++ G +K+ + S A+ + + +F Sbjct: 62 NLDIIKEIVHKFDLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKFP 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I +G+D A+ G V+ + + ++ TLD+++EV GA ++ +N+ Sbjct: 122 NK-IALGLD----AKDGYLSVSGWKENSNQL------TLDFLKEVNDYGASRLIYTDINR 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG + + E+ V V + P+I SGG +++ +A +++G + + I + Sbjct: 171 DGTKESPNFEETTNVANVSNCPVIISGGVSSIDDIKKAKGLKNIEGIIVGKAIYDGDIKL 230 Query: 242 GEL 244 EL Sbjct: 231 EEL 233 >UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9Y4_9FIRM Length = 245 Score = 79.7 bits (195), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 103/217 (47%), Gaps = 14/217 (6%) Query: 1 MLAKRIIPCLDVRDGQVV---KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 M A + P +D+R G V KG + D +A+R+AE GA + D+ + Sbjct: 1 MEAMNLYPAIDLRGGMCVRLEKGNFSKETVYSKDPGAMARRFAEAGARTIHVVDLDGALA 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ + S + + I V GGI++ E +LS G ++ + S A+ DP L+ R Sbjct: 61 GKSENLSAIKAILREGGISIEVGGGIRTYEQIEGLLSLGVSQVILGSAAIYDPQLVERAN 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 F + IVVGI DA+ G + + D + T E L + V G I+ Sbjct: 121 RDFPYK-IVVGI----DAKNGYAAADGWEKDSNLT----AEAL--ARRVAAAGTERIIFT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 +++DG+ NG ++E + + C VP+ ASGG ++E Sbjct: 170 DISRDGMMNGSNIEATAALYQACGVPITASGGVSSLE 206 >UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=104 Tax=Bacteria RepID=HIS4_CLOB1 Length = 242 Score = 79.0 bits (193), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 129/241 (53%), Gaps = 15/241 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+++G+ ++ Q F+ +++ D + +A ++ E GA+ + D+ + G + + Sbjct: 3 ILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S +S + + I+IP + GGI++L ++ G +++ + + AL + L+ ++ Sbjct: 63 LSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKYD- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I +GI DA+ K +N + V+ +D+ +E++K G I+ +++D Sbjct: 122 EKIAIGI----DAKNEKVAINGW------LNVSSINYIDFAKEMEKIGVRNIIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G +L+QL+K+ E + +IASGG +E L+ ++ DV GA+ + IN+ Sbjct: 172 GTLKGPNLKQLEKLNESINCNVIASGGIKDIED-LKGIKEMDVYGAIVGKAIYSGNINLN 230 Query: 243 E 243 E Sbjct: 231 E 231 >UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6X1_NATTJ Length = 246 Score = 78.6 bits (192), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 110/216 (50%), Gaps = 14/216 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVP-LAKRYAEEGADELVFYDITASSDG 58 ++ +IP +D+ +G+ V+ + + ++ D +A+ + E+GA L D+ + G Sbjct: 1 MSLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 V + + + ++A + IP V GGI+S+E ++++ G D++ + + A D + + Sbjct: 61 SVKNSTIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 F + I+VG+D + GK E V+ +T D++ E+ + G ++L Sbjct: 121 LFH-KNIIVGVDI----KGGK------VATEGWVNVSDTKTYDYLSELTELGVPRVILTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 +++DG G +LE K++ + L+ SGG ++E Sbjct: 170 ISKDGKLQGPNLELFKELAIFTELDLVLSGGMSSLE 205 >UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Salinibacter ruber DSM 13855 RepID=HIS4_SALRD Length = 258 Score = 78.6 bits (192), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 112/217 (51%), Gaps = 14/217 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+RDG+ V+ Q + N + D V +AK + + A L D+ A+ + Sbjct: 4 VIPAIDIRDGRCVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEHN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + +DIP + GGI+S++ L G ++ + + A+ +P + R ++F Sbjct: 64 RDVIGKMCDALDIPIQLGGGIRSMDQIEAALDRGVYRVILGTAAVRNPDFVERAVEQFSA 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV I DA G+ V + T + + + + +++++RG +V +++D Sbjct: 124 RRVVVSI----DARDGEVRVQGW------TEGSGLDAVAFAKDMEQRGVRRLVYTDISRD 173 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLE 218 G +G +++ + + R++ H + ASGG G + L+ Sbjct: 174 GTMDGPNIQAYRTLGRQLAHAKVTASGGVGEHDDLLD 210 >UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Halobacteriaceae RepID=HIS4_HALWD Length = 245 Score = 77.0 bits (188), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 107/212 (50%), Gaps = 13/212 (6%) Query: 5 RIIPCLDVRDGQVVKGVQF-RNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++DG VV+ VQ R E GD V AK++ E GA L D+ + +G ++ Sbjct: 9 EVIPAVDMQDGDVVQLVQGERGTETRYGDPVVAAKQWVEAGAKTLHLVDLDGAFEGDRMN 68 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + +DIP + GGI++ DAA +L G +++ + + A+ +P L+ LA+ + Sbjct: 69 ATAVDAIIDAVDIPVQLGGGIRTANDAASLLDRGVNRVILGTAAVENPDLVAELAESYPG 128 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV DA G+ V+ +T ES T + GA I+ ++ + Sbjct: 129 RIIV-----SLDAADGEVVVSGWT--ES----TGIDPAVAAARFADYGACGILFTDVDVE 177 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 G G +V + +P+IASGG +++ Sbjct: 178 GKLAGIQSSVTARVIDAVDIPVIASGGVASLD 209 Score = 45.4 bits (106), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/93 (33%), Positives = 47/93 (50%), Gaps = 2/93 (2%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 RII LD DG+VV + I D A R+A+ GA ++F D+ + S Sbjct: 129 RIIVSLDAADGEVVVSGWTESTGI--DPAVAAARFADYGACGILFTDVDVEGKLAGIQSS 186 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGA 97 +RV + +DIP +GG+ SL+D + + GA Sbjct: 187 VTARVIDAVDIPVIASGGVASLDDIQTLHTTGA 219 >UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillus RepID=HIS4_LACPL Length = 241 Score = 76.6 bits (187), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 63/235 (26%), Positives = 111/235 (47%), Gaps = 18/235 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRV 60 + I P +D+R GQ V+ Q F+ +I D V A++ G +L D+ + GR Sbjct: 2 QMIFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSGRP 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ + + + GGI++ E A + L G D++ + S AL DP L+ RL F Sbjct: 62 ENFATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLSEF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IV+G+D N Y + +Q + ++ + GA ++ + Sbjct: 122 GGERIVIGLD----------GTNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTDVA 171 Query: 181 QDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTME--HFLEA--FRDADVDGALA 230 +DG G +L ++++ +V LIASGG + L+A F+D + ALA Sbjct: 172 RDGTMQGPNLALYQELQAQVPTANLIASGGVRNLTDVQVLQASGFKDVIIGKALA 226 >UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrionales RepID=HIS4_DESDA Length = 250 Score = 76.3 bits (186), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 114/249 (45%), Gaps = 17/249 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+++G+ V+ Q R HE V A+ + E GA L D+ + DG Sbjct: 3 IFPAVDIQNGKAVRLKQGRAHESTVFAESPVDAARAWEEAGARWLHVVDLDGAFDGAAQS 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + IP + GGI+ + A L G ++ I + AL PTL + F Sbjct: 63 RRIVRDICAALAIPVQLGGGIRDMHTAEAYLEAGVSRLIIGTLALEQPTLFADMCRAFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + VG+ DAE G+ + D T T + + GA ++ + +D Sbjct: 123 R---VGVS--LDAEGGRLKSRGWVEDTGMTVDTA------LPRLLDDGAAFVIYTDIERD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR---DADVDGALAASVFHKQII 239 G++ G ++ L+ + + VP+IA+GG T+E + + + + GA++ ++ + Sbjct: 172 GMQCGVNVAALEHLARLSTVPVIAAGGVATLEDIQKLYPLTLETSLMGAVSGRALYEGTL 231 Query: 240 NIGELKAYL 248 ++ E A++ Sbjct: 232 DLKEANAWI 240 >UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Listeria grayi DSM 20601 RepID=C2BYH3_LISGR Length = 240 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 118/243 (48%), Gaps = 15/243 (6%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEII-GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +I P +D+++G+ V+ Q F ++ D + A ++A GA L D+ + G+ Sbjct: 2 QIFPAIDIKNGKCVRLYQGDFAKETMMNADPIDQAAKFAAAGATFLHIVDLDGAVSGKPT 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + R+ + + IP V GGI+++ L GA+++ I S AL+DP + ++G Sbjct: 62 NIALIQRLQQQVKIPIQVGGGIRTMTQVDTYLRAGAERVIIGSAALSDPDFVKAAVTKYG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I++GID N + E +++ + + E+ K G I+ +++ Sbjct: 122 DK-IIIGIDAK----------NGFVATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDISK 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G + E+L+ +++ + +IASGG + LE GA+A ++ I + Sbjct: 171 DGTLAGPNFEELRAIQKSARIAVIASGGVSSKAD-LEQLAAEGFYGAIAGKALYEGKITM 229 Query: 242 GEL 244 ++ Sbjct: 230 ADV 232 >UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=16 Tax=Campylobacter RepID=HIS4_CAMJD Length = 244 Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 106/217 (48%), Gaps = 13/217 (5%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAK--RYAEEGADELVFYDITASSDGRV 60 +IIP LD+ DG+VV+ V+ ++ ++ PL K Y + GA EL D+T + D Sbjct: 3 QIIPALDLIDGEVVRLVKGDYKQKKVY-KYNPLKKFKEYEKAGAKELHLVDLTGAKDPSK 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++A+ + + V GGI+S E+ +L G ++ I S A+ D TL + +F Sbjct: 62 RQLVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IV+ +DT + Y V E+ + E LD+ +G I+ ++ Sbjct: 122 GSEAIVLALDTILKED---YVVAVNAWQEASDK-KLMEVLDFYSN---KGLKHILCTDIS 174 Query: 181 QDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHF 216 +DG G ++ K + E+ + + ASGG +++ Sbjct: 175 KDGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDL 211 >UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sp. AT1b RepID=C4L175_EXISA Length = 237 Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 64/245 (26%), Positives = 116/245 (47%), Gaps = 22/245 (8%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELV-FYDITASSDG--R 59 R++P +D+ G++V+ + F E GD L K + +G ++ D+ + G R Sbjct: 2 RLLPAIDLIGGKIVRLTEGDFSTEEQYGDPYELLKAW--QGKVPMIHLIDLEGAKAGEPR 59 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 +D V R A+ + GGI+S ++ GAD++ + + A DP + + ++ Sbjct: 60 HLD---VVRYAKSLGFLVQTGGGIRSEASLDAVMETGADRVLLGTKAFTDPDFLDKAIEK 116 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 +G + V DA GK +N + T+ + + Q++ KRG I+ + Sbjct: 117 YGKRVAVA-----LDAYDGKVAINGWQ------EATKLDDISVAQDLVKRGIETILYTDI 165 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG NG ++ ++K +R++ +V LIASGG T E E + A +D A+ + Sbjct: 166 GSDGKLNGPNVTRMKALRQIVNVTLIASGGVTTEEDVKE-LKMAKIDEAVVGKALLSGKV 224 Query: 240 NIGEL 244 +I EL Sbjct: 225 SIEEL 229 >UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_DESAP Length = 262 Score = 74.7 bits (182), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 117/252 (46%), Gaps = 28/252 (11%) Query: 6 IIPCLDVRDGQVVKGVQFR-NHEII--GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+R G+ V+ Q R + E + D V +A+ + E+GA L D+ + G+ + Sbjct: 3 IIPAVDLRGGRCVRLFQGRADQETVYSTDPVAVARTWEEQGARRLHVVDLDGAFTGKPQN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V + + ++IP V GGI++ E+ L G D++ + + AL +P + + +G Sbjct: 63 SGVVLDIVKSVNIPVQVGGGIRNPENVKCYLEHGVDRVILGTAALTNPEFLDAVVAAYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWE------TLDWVQEVQKRGAGEIVL 176 + IVVG+D + R V WE L +++E+ +RG +V Sbjct: 122 ERIVVGVDCR----------------DGRVCVQGWEQTAATDVLPFLEELVRRGVRRVVF 165 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVF 234 + +DG G +LE++ +V + +IASGG +E L+ VD + Sbjct: 166 TDVKRDGTLEGPNLEEIARVAAHTELKVIASGGVSRLEDLRALKKLEHLGVDSVIIGKAL 225 Query: 235 HKQIINIGELKA 246 + I + E A Sbjct: 226 YAGTITLAEALA 237 >UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41EB6 Length = 246 Score = 74.7 bits (182), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/252 (21%), Positives = 131/252 (51%), Gaps = 18/252 (7%) Query: 6 IIPCLDVRDG---QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+R G Q+V+G +I + +AK++ + GA+ + D+ + + V + Sbjct: 10 IMPAVDIRGGKCVQLVQGKPGSEQVVIENPEKVAKKWEDAGAEVVHVIDLDGALE-SVTN 68 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + +P + GGI+S+E A ++L+ D++ I + + +P +I++L++ +G Sbjct: 69 IETIKKILNEVSVPIQLGGGIRSIEYAEELLNLDIDRLIIGTMGIKNPEIISKLSNEYGS 128 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +++ +D+ + K Q D+S + ++ +E Q+ GAG I+ ++ + Sbjct: 129 ERVMISLDSKDNKVVIKGW--QEKIDKSASEIS--------KEFQELGAGSILFTNVDVE 178 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G+ ++ + + + +P++ SGG +++ L+ + G + S +K I Sbjct: 179 GLLGGFYVDPVIDLVDSVDIPVVYSGGVTSLDD-LKQLQTTGAKGVVIGSALYKDKI--- 234 Query: 243 ELKAYLATQGVE 254 +L+ L Q +E Sbjct: 235 KLEDALKYQNIE 246 >UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=97 Tax=Gammaproteobacteria RepID=HIS4_YERP3 Length = 245 Score = 74.3 bits (181), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 116/247 (46%), Gaps = 20/247 (8%) Query: 6 IIPCLDVRDGQVVKGVQ--------FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 IIP LD+ +G+VV+ Q + NH + P + Y ++GA L D+T + D Sbjct: 2 IIPALDLIEGKVVRLHQGDYGQQRDYGNHPL-----PRLQDYQQQGAQVLHLVDLTGAKD 56 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + + +D+P V GGI++ +D +L GA ++ + S A+ P ++ + Sbjct: 57 PAARQIPLLRELLAGVDVPVQVGGGIRNEQDVVALLEAGAARVVVGSTAVKQPEMVQQWF 116 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +R+G + IV+ +D + E G HV +G + + T + V++ G ++ Sbjct: 117 ERYGAEAIVLALDVRIN-EAGCKHVA-ISGWQENSDATLEQI---VEQYLPYGLKHVLCT 171 Query: 178 MMNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +++DG +G ++E ++V + V ASGG G ++ + R + V G + Sbjct: 172 DISRDGTLSGSNVELYQEVCQRYPQVAFQASGGIGCLDD-IARLRGSGVQGVIVGRALLD 230 Query: 237 QIINIGE 243 N+ E Sbjct: 231 GKFNVKE 237 >UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Caulobacter RepID=HIS4_CAUSK Length = 241 Score = 73.9 bits (180), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 113/246 (45%), Gaps = 26/246 (10%) Query: 8 PCLDVRDGQVV--------KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 P +D++DGQ V K F N A+R+ +G L D+ + +G+ Sbjct: 5 PAIDLKDGQCVRLLHGDMEKATVFNNSP-----ADQAERFVRDGFSWLHVVDLNGAIEGK 59 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V+ + V + E I IP + GGI++LE + G ++ + + A+ DP L+ R A R Sbjct: 60 SVNTAAVQSILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPDLV-RKAAR 118 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 + I V +D GK V+ +TG ++ + + + + G +++ + Sbjct: 119 LWPEQIAVAVDV----RDGKVAVDGWTG------LSDLDAITLGKRFEDVGVAALIVTDI 168 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQ 237 ++DG G ++E + ++ + +P+IASGG ++ L+A ++ GA+ + Sbjct: 169 SRDGALTGVNVEGVGELADAVSIPVIASGGVASVADIERLKARPGVEIAGAILGRSLYAG 228 Query: 238 IINIGE 243 I E Sbjct: 229 TIRPAE 234 >UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrio RepID=HIS4_DESVH Length = 249 Score = 73.6 bits (179), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 60/250 (24%), Positives = 109/250 (43%), Gaps = 33/250 (13%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+ +G V+ + R + D V A+ + E+G L D+ + G+ V+ Sbjct: 3 VFPAIDLMNGVCVRLRRGRADDETVFSSDPVATARHWQEQGGRWLHVVDLDGAFSGQPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP----TLITRLAD 118 + + + +DIP + GGI+ A L G +++ I + AL +P L Sbjct: 63 APLIRSICDALDIPVQLGGGIRDAATAKAYLEAGVERLIIGTIALEEPDAYAALCAEFPG 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR----GAGEI 174 R GV DAE GK + D T V EV R G I Sbjct: 123 RIGVS---------LDAEGGKLKTKGWVADSGLT----------VDEVLPRLLEAGTAFI 163 Query: 175 VLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF---RDADVDGALAA 231 + +++DG++ G +L L+ + + VP+IA+GG T+E + R ++ GA++ Sbjct: 164 IYTDIDRDGMQTGVNLPALEHLAKASTVPVIAAGGVATLEDVKALYPLSRTTNLQGAVSG 223 Query: 232 SVFHKQIINI 241 ++ +++ Sbjct: 224 RAIYEGTLDL 233 >UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CALS8 Length = 237 Score = 73.6 bits (179), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/242 (25%), Positives = 109/242 (45%), Gaps = 14/242 (5%) Query: 6 IIPCLDVRDGQVVKGVQ---FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q R E D V AK + +EGA L D+ + G V+ Sbjct: 3 VIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+ E + GGI+ + L G D I + S +P + + RFG Sbjct: 63 FEVIKRIKESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRFGN 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + +D E G + +G + TR++ E + ++K G +++ + D Sbjct: 123 ERFIASLDF----EEGYVKL---SGWQEATRISVEEG---ILHIKKLGFQKLIYTDIKTD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G++ E K +R + LI+SGG +M L+ +D VDG + + + + Sbjct: 173 GMLKGHNFEAAKYIRSLFDGFLISSGGISSMNDVLK-LKDIGVDGVIIGKALYTGHVKLN 231 Query: 243 EL 244 E+ Sbjct: 232 EI 233 >UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=144 Tax=Bacteria RepID=HIS4_CORJK Length = 258 Score = 72.4 bits (176), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/255 (25%), Positives = 118/255 (46%), Gaps = 15/255 (5%) Query: 3 AKRIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 A ++P +DV DGQ V+ VQ G + A + GA+ + D+ A+ GR Sbjct: 9 ALTLLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAF-GRG 67 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V +D+ ++GGI+ E + LS G +++I + AL DP + R+ Sbjct: 68 SNFELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRY 127 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + + +G+DT + +T D WE L + + +G +V+ ++ Sbjct: 128 GDK-VAIGLDTREVDGEWRLRGRGWTSDGGEL----WEVL---ERLDSQGVSRLVVTDVS 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQI 238 +DG+ NG +++ L++V P++ASGG +++ L A VD A+ + Sbjct: 180 RDGMLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGK 239 Query: 239 INIGELKAYLATQGV 253 + E A A QGV Sbjct: 240 FTLEE--ALEAAQGV 252 >UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillales RepID=HIS4_LACC3 Length = 238 Score = 72.4 bits (176), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 111/244 (45%), Gaps = 14/244 (5%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++ P +D+ +G+ V+ Q + + D + A+R + G L D+ + R ++ Sbjct: 2 KLYPAIDLLNGKSVRLTQGDYDQVSLTEDPLYQAQRLTDAGFAHLHLVDLDGARAQRPIN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 ++ ++R+ E + GGI++L L+ G D++ + S A++DP L+ + RFG Sbjct: 62 RTVITRIREQTSAFIELGGGIRTLAAMEIYLTIGIDRLILGSAAVSDPDLVEQAIARFGS 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VGIDT GK N + +T + +Q+RG ++ + +D Sbjct: 122 NRIAVGIDT----RAGKVATNGWLTTSQQTANA------LLTAMQQRGVTTFIVTDIAKD 171 Query: 183 GVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G + + L +++ +IASGG + L + A + A+ + I + Sbjct: 172 GMMQGPNAQLLADLQQAMPQATIIASGGISLLAD-LHRLQTAGIQAAIIGKAWQTGAIEL 230 Query: 242 GELK 245 LK Sbjct: 231 AMLK 234 >UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=23 Tax=Bacteria RepID=HIS4_THEEB Length = 257 Score = 70.5 bits (171), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 101/219 (46%), Gaps = 16/219 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG----DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IP +D+ DG+ V+ VQ N++ + D + +A + GA L D+ A+ G Sbjct: 3 VIPAIDLLDGKCVRLVQ-GNYDKVNVFHDDPLKVALYWQRLGAPRLHLVDLDAAKTGEPR 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + ++ ++IP V GG++S + A + G ++ + + AL +P L+ LA + Sbjct: 62 NYDLIGKIVASLEIPVQVGGGLRSRQAVADLFLQGVNRAILGTVALENPKLVASLAAEYP 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I VG+ DA G Y ++ D Q + G V + + Sbjct: 122 GR-IWVGL----DARDG------YVATRGWLETSKILATDLAQNMAAMGVAGFVYTDIQR 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 DG G ++ L+++ V + P+IASGG ++ L F Sbjct: 171 DGTLQGPNIPALRQLLAVTNRPVIASGGVSSLNDILSLF 209 >UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF74_THET1 Length = 243 Score = 70.5 bits (171), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 103/234 (44%), Gaps = 15/234 (6%) Query: 6 IIPCLDVRDGQVVKGVQ---FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ +GQ+V+ Q R D V +A+++ GA L D+ + G V+ Sbjct: 3 VIPAIDILEGQLVRLTQGDYSRKKVYSYDPVVVARKWKAIGAQWLHVVDLDGARQGHPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V V GG+++LED I+ GA +I + + A+ DP + + ++ Sbjct: 63 VDVIKSVIMEFGPQVQVGGGLRTLEDIQSIVELGASRIVLGTSAVKDPEFLREVCAKYP- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +V +DT N + T+ + + L+ + V+ G G I+ + D Sbjct: 122 DMVVAALDTR----------NGVVAIDGWTKSSGLDVLEVAKLVEDAGVGYILFTAIETD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 G G D+ ++++ VP+IASGG E LE A V + ++ Sbjct: 172 GTMTGPDIAAVQRLMSHVSVPVIASGGISEPED-LEELSKAGVYAVIVGKALYE 224 >UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Lactobacillus rhamnosus RepID=C7TCJ1_LACRG Length = 249 Score = 70.1 bits (170), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 59/244 (24%), Positives = 113/244 (46%), Gaps = 14/244 (5%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++ P +D+ GQ V+ Q +R + D + K G L D+ + + ++ Sbjct: 2 QLYPAIDLLAGQSVRLTQGDYRQVSLTADPLTQVKNLTATGLKHLHLVDLDGARSQQPIN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 ++ +S + + + GGI++L L+ G D++ + S A+ +P L+T+ +FG Sbjct: 62 QAVISTIRQHTPAFIELGGGIRTLAIMDHYLNAGIDRLILGSVAVTNPELVTQAVQKFGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VGI DA GK + + T TQ T +Q + +RG ++ + +D Sbjct: 122 DKIAVGI----DARAGKVATDGWL-----TTSTQSPT-HLMQAMVRRGVTTFIVTDIGRD 171 Query: 183 GVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G ++ L + + V +V ++ASGG T+ L A + A + A+ + + Sbjct: 172 GMMKGPNVALLAMLHQTVPNVNIVASGGVHTLAD-LTALQTAGIQAAVIGKAWQTGSFPL 230 Query: 242 GELK 245 +LK Sbjct: 231 NKLK 234 >UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Aquificales RepID=HIS4_SULSY Length = 239 Score = 70.1 bits (170), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 58/249 (23%), Positives = 123/249 (49%), Gaps = 18/249 (7%) Query: 2 LAKRIIPCLDVRDGQVV---KGVQFRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSD 57 L + IIP +D++ G+VV KG +F ++ + + +AK + + GA+ + D+ + + Sbjct: 3 LKEFIIPAIDIKGGKVVRLYKG-EFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALE 61 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G + + + ++IP GG++S E +L G +++ I S A +P ++ Sbjct: 62 GLPKNIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIV 121 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + F ++VGI DA+ GK + +T +T V+ E ++ G + Sbjct: 122 ESFP-NKVIVGI----DAKDGKVAIKGWT---EKTEVSPLEFAKKYDDLDIFG---FLFT 170 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF--RDADVDGALAASVFH 235 +++DG G ++E ++ + P+IASGG G++E ++ + R+ + G + + Sbjct: 171 DVSRDGSMIGANVEATVELAKNLKHPVIASGGVGSLEDVIKLYEKREFGIFGVVVGKAIY 230 Query: 236 KQIINIGEL 244 + I++ E+ Sbjct: 231 EGKIDLKEI 239 >UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Persephonella marina EX-H1 RepID=HIS4_PERMH Length = 241 Score = 70.1 bits (170), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 60/249 (24%), Positives = 114/249 (45%), Gaps = 16/249 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDG 58 L +IP +D++DG+ V+ + + D V +AK++ E+GA L D+ + +G Sbjct: 3 LRSFVIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + V + + + IP GG++S E I+ G +++ I S A + R+ Sbjct: 63 KPKNIDIVKDIVKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVS 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 + + I VGI DA+ GK + + T++ LD+ + + Sbjct: 123 AYPGKVI-VGI----DAKDGKVAIKGW------LEKTEYTPLDFARMFDDLDIWGFLYTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHK 236 +N+DG G ++E K + + P+IASGG G++E L + V G + ++ Sbjct: 172 VNRDGAMVGPNIEGTKYLAQNLKHPVIASGGVGSVEDLKKLYDLKKYGVYGVVVGKALYE 231 Query: 237 QIINIGELK 245 I + +L+ Sbjct: 232 GKIKLEQLE 240 >UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MJ01_RHOM4 Length = 266 Score = 69.7 bits (169), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 102/214 (47%), Gaps = 27/214 (12%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+R G+ V+ G R D V +A + + A L D+ A+ G+ + Sbjct: 4 VIPAIDIRGGRCVRLYQGSYERETVYFDDPVKMACLWRVQNARVLHVVDLDAAR-GQGHN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + +DIP V GG+++LED +L G ++ + + A+ +P L++ R+G Sbjct: 63 REVIGAICRTVDIPIQVGGGVRTLEDIEALLQVGVYRVVLGTAAVREPELVSEAIARYGC 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +VVGI DA G+ V +T T + ++ ++++RG V +++D Sbjct: 123 SRVVVGI----DARDGEVRVQGWTEG------TGVDAVELALDMERRGVRRFVYTDISRD 172 Query: 183 GVRNGYDLE-------QLKKVREVCHVPLIASGG 209 G G ++E LKK R + ASGG Sbjct: 173 GTLEGPNVEMYRTLGLHLKKAR------ITASGG 200 >UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_FRAP2 Length = 241 Score = 69.7 bits (169), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 114/244 (46%), Gaps = 13/244 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFR-NHEIIGDIVP--LAKRYAEEGADELVFYDITASSDGRVV 61 I P +D+ +G+ V+ + N ++ P +AK Y + GA+ + D+ + G+ Sbjct: 2 NIFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQTC 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++ E ++ V GG+K E K+L G D++ I S A+ D L + +++G Sbjct: 62 QFETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKYG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM-MN 180 + IV+ +D + + G ++ + ES T TLD + + E VL ++ Sbjct: 122 AEKIVLALDVF--IKNGVPYIATHGWQESSTT-----TLDEILQTYLGDGLEYVLCTDIS 174 Query: 181 QDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G + E + + V +ASGG G++E LE ++ + G + ++ Sbjct: 175 RDGMLQGPNFELYRIYSSIYPDVQFMASGGVGSLED-LEILKEQNTYGVIIGKALYENKF 233 Query: 240 NIGE 243 + E Sbjct: 234 TLQE 237 >UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Bacillales RepID=HIS4_BACLD Length = 245 Score = 68.9 bits (167), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/243 (21%), Positives = 110/243 (45%), Gaps = 16/243 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+R+G+ V+ +Q + I G + +A R+AEEGA + D+ + +G+ V+ Sbjct: 6 VYPAIDIRNGKCVRLIQGDYEKETIYGHSPLEMASRFAEEGASWIHLVDLDGAREGKKVN 65 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V +A+ +D+ V GGI++ +D LS G +++ + S A+++ + ++ +G Sbjct: 66 GGHVISIADKLDVKVQVGGGIRTEKDVYDYLSQGVERVILGSSAVSNTEFVKKMLKAYGG 125 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I +G+D + + E + + +E+ GA + + D Sbjct: 126 H-IAIGLDAR----------DGFVSTEGWLETSSVRAEELGRELANEGAEVFIFTDIATD 174 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIIN 240 G+ +G ++ ++ +IASGG ++ L + V GA+ + Sbjct: 175 GMLSGPNINSTVELARATGKQVIASGGVSSLADLEALASRASEGVSGAIVGKALYTNQFT 234 Query: 241 IGE 243 + E Sbjct: 235 VAE 237 >UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodopirellula baltica RepID=HIS4_RHOBA Length = 253 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/245 (24%), Positives = 110/245 (44%), Gaps = 18/245 (7%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITAS-SDGRVV 61 I P +D+R G+ V+ Q + GD V AKR+ E GA L D+ A+ D Sbjct: 14 IWPAIDLRHGKPVRLRQGDYDQQTTFGDDPVEFAKRWQESGAKRLHLVDLDAARGDSPDA 73 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 ++ V R+ E +P + GG++ +L+ G ++ + S AL DP + D++ Sbjct: 74 NRDAVQRIIEATGLPCQMGGGVRDEITIESLLNVGVTRLVVGSRALKDPDWFVEMCDKYP 133 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR--GAGEIVLNMM 179 + +V GI DA GK + + ++ +++ R IV + Sbjct: 134 GK-LVAGI----DARDGKVATQGW------LETSDVSAFEFATKLRSRTENIAAIVYTDI 182 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G + E L ++ +PL+ASGG T + ++ + + A+ + ++ Sbjct: 183 AKDGMMQGPNFEGLAEMAAASDIPLVASGGVTTYDD-IKQLVEMKMPAAIVGRSLYDGVM 241 Query: 240 NIGEL 244 +GE+ Sbjct: 242 ELGEV 246 >UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sibiricum 255-15 RepID=B1YL10_EXIS2 Length = 234 Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 108/227 (47%), Gaps = 15/227 (6%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++ P +D+ GQ V+ Q F+ GD + +A+R+ E+GA + D+ + G + Sbjct: 2 QLYPAIDLMSGQAVRLKQGDFQQQTFFGDALTIARRFKEDGATAIHLIDLDGAKAGEPLH 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S ++ + + + GG++++E + G D+I I + AL D L+ ++ +R G Sbjct: 62 LSLIADIKKETGLFVEAGGGVRNIETVEAYVGAGIDRILIGTVALEDEALLEQMIERAGD 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V DA+ G + + W ++ + ++G + +++D Sbjct: 122 KLAVA-----LDAKDGIVQTRGW------LEASDWTLERAIEHLIQKGIKTFLYTDISRD 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGAL 229 G+ G D++ L ++ V LIASGG T+E + ++ +DGA+ Sbjct: 171 GMMQGPDVDGLDLLKR-DGVELIASGGVTTVED-VARLKEIGMDGAV 215 >UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Firmicutes RepID=HIS4_CLOD6 Length = 240 Score = 67.8 bits (164), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 56/241 (23%), Positives = 119/241 (49%), Gaps = 15/241 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++D + V+ Q F + D + +A ++ EGA+ + D+ + V+ Sbjct: 3 IFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A IDIP V GG++ E +++ G ++ + S A+ + L+ L + + Sbjct: 63 TKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEYK- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IVV I DA+ GK V + V+ ++L ++++K G IV +++D Sbjct: 122 EKIVVSI----DAKDGKVAVRGW------EVVSNVDSLTLCKQLEKIGVQTIVYTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G + + +++ + + +IASGG ++E ++ + ++ GA+ + + I+ Sbjct: 172 GMLQGPNFDIYERIAKETSLNVIASGGVTSIED-VKRLKAMNLYGAIIGKALYDKKIDFK 230 Query: 243 E 243 E Sbjct: 231 E 231 >UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=24 Tax=Bacteroidetes RepID=HIS4_PARD8 Length = 239 Score = 67.4 bits (163), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/243 (21%), Positives = 116/243 (47%), Gaps = 15/243 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q + ++ D + +AK + G L D+ + +GR+++ Sbjct: 4 LIPAIDIIDGKCVRLTQGDYATKKVYNEDPLEVAKMFEGNGIRRLHVVDLDGAREGRIIN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+A + GG+K +D GA ++ S A+ +P + T +FG Sbjct: 64 YRILERIATRTSLIIDFGGGLKQEDDLEIAFESGAQMVTGGSIAVKNPEMFTSWISKFGS 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++G DA+ K ++ + T E + +++ +G +++ + +D Sbjct: 124 EKIILG----ADAKEKKIAISGW------EETTSQELVPFIKGYYDKGITKVICTDIARD 173 Query: 183 GVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G ++ K++R E+ + +IASGG ++E +E +A + + ++ I + Sbjct: 174 GMLQGPAIDLYKEIRDEIPFLYIIASGGVSSIED-IEKLSEAGIPAVIFGKAIYEGKIQL 232 Query: 242 GEL 244 +L Sbjct: 233 KDL 235 >UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=12 Tax=Bacteria RepID=HIS4_BRAHW Length = 238 Score = 67.0 bits (162), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 51/242 (21%), Positives = 118/242 (48%), Gaps = 15/242 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+++G+VV+ V+ + N D + + + E G+ L D+ +SDG ++ Sbjct: 3 ILPAIDLKNGEVVRLVEGNYDNKTTYFKDPLEVLDFFIESGSSYLHVVDLDGASDGETIN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +V + D+ V GGI++ + K L G + + + A+ + + +++ Sbjct: 63 FKTIEKVIKKCDLFVEVGGGIRNEDTIKKYLDIGVKRTILGTAAVENIDFTNNMINKYK- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I V ID+ ++ + + + +++++ ++ G I+ +++D Sbjct: 122 EHIAVSIDSR----------DRMIAVKGWKEINKQDSVEFCMKLDSMGIDTIIYTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G +G +L+ K++RE +IASGG T E + RD ++GA+ ++ I++ Sbjct: 172 GKLSGTNLDIYKELREKISCNIIASGGV-TFEDEIIKLRDMKINGAIVGKAIYEGKIDLK 230 Query: 243 EL 244 ++ Sbjct: 231 KI 232 >UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Gammaproteobacteria RepID=HIS4_SHEDO Length = 250 Score = 66.2 bits (160), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 63/239 (26%), Positives = 110/239 (46%), Gaps = 31/239 (12%) Query: 6 IIPCLDVRDGQVVKGVQF-RNHEIIGDIVPLA--KRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ DGQVV+ Q + + D+ PLA K Y ++GA L D+T + D Sbjct: 2 IIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLKSYQDQGAKLLHIVDLTGAKDPNQRQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S + +D+ V GGI+S + ++L+ G ++ I S A+ +P L+ +++G Sbjct: 62 IKLISELVAGLDVDIQVGGGIRSEQQVTELLAIGVKRVVIGSLAVKEPELVKSWLNKYGS 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWE-----TLD-WVQEVQKRGAGEIVL 176 I + +D VN E V+ W+ TL+ V E ++ G+ + L Sbjct: 122 DAICLALD-----------VNINANGEKIVAVSGWQSAGGKTLESLVAEFERPGSKQTAL 170 Query: 177 NM-----MNQDGVRNGYDLEQLKKVREVCHVPLI---ASGGAGTMEHFLEAFRDADVDG 227 +++DG G + ++ P I ASGG T++ + A +D+ G Sbjct: 171 KHALVTDISRDGTLTGANTALYTEL--AAAYPTILWQASGGIATLDD-VSAVKDSKAAG 226 >UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=209 Tax=Bacteria RepID=HIS4_HERAR Length = 265 Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 55/251 (21%), Positives = 117/251 (46%), Gaps = 26/251 (10%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++DG V+ G + D +A+ + E+GA L D+ + G+ + Sbjct: 3 LIPAIDLKDGHCVRLKQGDMDQATVFSEDPADMARHWLEQGARRLHLVDLNGAFAGKPKN 62 Query: 63 KSWVSRVAEVI----------DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 + V + + + +IP + GGI+ L+ + L G I I + A+ +P Sbjct: 63 EPAVKAILQAVREYAEKNGIEEIPVQLGGGIRDLDTIERYLDDGLSYIIIGTAAVKNPGF 122 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 + F Q I+VG+D A+ GK + ++ +++ E +D ++ + G Sbjct: 123 LHDACSAFPGQ-IIVGLD----AKDGKVATDGWS------KLSGHEVIDLAKKFEDYGCE 171 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME--HFLEAFRDADVDGALA 230 I+ + +DG+ G ++E K+ + +P+IASGG ++ L A ++ ++G + Sbjct: 172 SIIYTDIGRDGMMGGVNIEATVKLAQSMTIPVIASGGVHNIKDVEALCAVQEEGIEGVIC 231 Query: 231 ASVFHKQIINI 241 ++ +++ Sbjct: 232 GRSIYEGTLDL 242 >UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3E3_9BURK Length = 251 Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/234 (25%), Positives = 106/234 (45%), Gaps = 23/234 (9%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADEL--VFYDITASSDGRV 60 IIP + ++DG+ V G + + D + LAK++A+ GAD L V + AS+ Sbjct: 3 IIPSIYIQDGKCVHVSYGDKTSSSPFEIDPLDLAKKWADLGADRLHIVQLGLNASTQNAT 62 Query: 61 V---DKSWVSRVAEVID--IPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + +S++ E + +P +AGGIK++ L G D + + S + DP + Sbjct: 63 SLSKNNEVLSKLIEEVSHYLPLQIAGGIKTMASIESYLDMGFDFVVVGSAGVKDPHFMND 122 Query: 116 LADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIV 175 F Q +++G+D A GK + ++ +VT+++ + Q + G I+ Sbjct: 123 ACSAFNGQ-VILGLD----ARDGKVVTDSWS------KVTKFDAVTIAQRLTDEGIDSII 171 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDG 227 M DG +LE + VP++A G G + F ++ D VDG Sbjct: 172 YTDMGPDGNMTEVNLEATLNFAKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDG 225 >UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=35 Tax=cellular organisms RepID=HIS4_GRAFK Length = 241 Score = 65.1 bits (157), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/251 (21%), Positives = 116/251 (46%), Gaps = 15/251 (5%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 RIIP +D+ +G+ V+ + + +I D + +AK + G + L D+ + +V Sbjct: 2 RIIPAIDIIEGKCVRLSKGDYATKKIYNEDPLEVAKSFEAHGIEYLHLVDLDGAKSSHIV 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + +A + GG+K+ +D GA +I+ S A+ + + +FG Sbjct: 62 NHKILETIANKTSLKIDFGGGLKTDKDLQIAFESGASQITGGSIAVKNSDVFQNWIQKFG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I++G DA+ K V+ + D + E + ++Q +++G ++ +++ Sbjct: 122 NKKIILGA----DAKDRKIAVSGWLEDSNE------EIIPFIQNYEEKGVKYVICTDISK 171 Query: 182 DGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ G E K++ E ++ LIASGG + L + +G + ++ I+ Sbjct: 172 DGMLEGPSFELYKEILSETKNINLIASGGISEFDE-LPKLAELGCEGVIIGKAIYENRIS 230 Query: 241 IGELKAYLATQ 251 + + + Y+ Q Sbjct: 231 LKQFENYILNQ 241 >UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=HIS4_THERP Length = 244 Score = 65.1 bits (157), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 58/241 (24%), Positives = 108/241 (44%), Gaps = 27/241 (11%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+R+G+ V+ G R D + +A+R+A GA L D+ + G+ V Sbjct: 3 VIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPVQ 62 Query: 63 KSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + RV + D+ V GG+++L+ ++L GA ++ I + AL P ++ RFG Sbjct: 63 HELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALARFG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR------GAGEIV 175 V+ +VV +D+ D + WET+ ++ + G ++ Sbjct: 123 VERVVVAVDS-RDGWVATHG---------------WETVQAIRVEEVVHRVVLLGVRRVL 166 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 + +DG +LE + ++ V +IASGG G+ R V+ A+ + Sbjct: 167 ATDVTRDGTLTRPNLELMGRL-AALGVTVIASGGVGSRSDLEALARVPGVEAAIVGRALY 225 Query: 236 K 236 + Sbjct: 226 E 226 >UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUX9_ALIAD Length = 252 Score = 64.7 bits (156), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/252 (25%), Positives = 117/252 (46%), Gaps = 19/252 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+ G+VV+ Q ++ GD +A R + GA L D+ A+ G+ + Sbjct: 8 VYPAIDILGGEVVRLRQGDYQQVTRYDGDPAGVAGRLCDAGARFLHVVDLDAARSGQSDN 67 Query: 63 KSWVSRVAEVI---DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + V + E V GGI++ + A+ L G ++ I + A+ ++ A Sbjct: 68 ERAVRAIVETAASYGAAVQVGGGIRTKDAIARWLEAGVARVVIGT-AVRQVEVVAEWAQE 126 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG +V G+D G+ V+ + + T+W D +E+ K G + ++ + Sbjct: 127 FGGHRLVAGLD----GRKGRLAVSGWLEE------TEWSIFDLARELAKVGLVQALVTDV 176 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G +L+ V+E + IASGG G+++ + A R A + GA+ H I Sbjct: 177 ERDGTGEGPNLDLALGVQE-TGLFAIASGGIGSIDDVV-AVRRAGLAGAVIGKALHDGRI 234 Query: 240 NIGELKAYLATQ 251 ++GEL LA + Sbjct: 235 HLGELFQRLAQE 246 >UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=C7PAV4_CHIPD Length = 389 Score = 64.3 bits (155), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/247 (23%), Positives = 111/247 (44%), Gaps = 15/247 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q + ++ + + +AK + G L D+ + G VV+ Sbjct: 148 VIPAIDIIDGKCVRLTQGDYAQKKVYNEHPLEVAKAFESIGIRRLHLVDLDGAKKGAVVN 207 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A ++ GGIK+ +D + GA +I S A+ DP L + ++G Sbjct: 208 WKVLEAIAGKTNLVIDFGGGIKTEDDLRIVYENGAALATIGSIAVKDPALFSGWVKKYGA 267 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I +G D + K V + T+ D+++E K+G I + +D Sbjct: 268 DKIFLGADV----KEEKIAVGGW------LETTELSVFDFLEENVKQGVQHIFCTDIAKD 317 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G + +K+ + + +ASGG TM + A +A G + +++ I++ Sbjct: 318 GLLQGPSVALYEKILQRFPQIDFVASGGVSTMAD-VHALAEAGCSGVIVGKAIYEERISM 376 Query: 242 GELKAYL 248 EL ++ Sbjct: 377 KELADFI 383 >UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Bacillales RepID=HIS4_BREBN Length = 249 Score = 63.5 bits (153), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/243 (21%), Positives = 102/243 (41%), Gaps = 16/243 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGDI-VPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+R G+ V+ Q + + D + +AKR+ E+GA + D+ + +G+ + Sbjct: 5 VYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEGKPAN 64 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +A I +P V GGI++ E A L G ++ + + A+ D R+ G Sbjct: 65 AAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQNDGD 124 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I +G+D N T + + + + GA + + +D Sbjct: 125 K-IAIGLDCR----------NGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTDIARD 173 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD--VDGALAASVFHKQIIN 240 G G ++E++ + +IASGG ++ L A V GA+ + Sbjct: 174 GTMTGPNVEEIAALAMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYTDAFT 233 Query: 241 IGE 243 + E Sbjct: 234 LEE 236 >UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Leptospirillum RepID=A3EUM5_9BACT Length = 247 Score = 63.5 bits (153), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 56/250 (22%), Positives = 113/250 (45%), Gaps = 31/250 (12%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+R+G+VV+ Q F + G D V A ++ E G L D+ + +G V Sbjct: 2 QLYPAIDIRNGKVVRLTQGRFDQETVYGEDPVRTALQFRERGVQHLHVVDLDGAREGVPV 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP----TLITRLA 117 ++S + + + V GG++S + A+ G ++ + + A+ DP ++I + Sbjct: 62 NRSLIREIVKAFRGFVQVGGGVRSKDIASFYYDAGVSRLILGTAAIKDPVFLGSMIEQHP 121 Query: 118 DRFGVQCIV----VGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 D F V V + ++ W D +T + L+ + + + G Sbjct: 122 DLFYVGIDVKDESLAVNGWLDLDT-------------------QDPLEVMVRMSELGVRG 162 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 V +++DG+ +G + + + +R VP+IASGG + + R+ VDGA+ Sbjct: 163 FVYTDIHRDGLLSGPNFARYETLRRTVRVPVIASGGVRDISD-IARLREIGVDGAIVGKA 221 Query: 234 FHKQIINIGE 243 + +++ E Sbjct: 222 IYTGEMDLTE 231 >UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Proteobacteria RepID=HIS4_NITSB Length = 238 Score = 63.5 bits (153), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 51/241 (21%), Positives = 106/241 (43%), Gaps = 16/241 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGDIV-PLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D++DG+ V+ + + +I D +AKR+ E G+ L D+ + G + Sbjct: 3 ILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEPKN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + + GGI+ E K + G +++ + S A+ +P + +A ++ Sbjct: 63 LEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKY-- 120 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VGID ++ + E + + D +E K G I+ + +D Sbjct: 121 -PIAVGIDA----------IDGFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVGKD 169 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G +G +++ + E + IASGG +E + V G + F++ +++ Sbjct: 170 GTLSGVNVDFTVSIAEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLDLE 229 Query: 243 E 243 E Sbjct: 230 E 230 >UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=92 Tax=Proteobacteria RepID=HIS4_ACTP2 Length = 250 Score = 63.5 bits (153), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 55/245 (22%), Positives = 114/245 (46%), Gaps = 16/245 (6%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD+ DG VV+ G + + + Y +GA++L D+T + Sbjct: 7 IIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFANYLAQGAEQLHLVDLTGAKYPAKRQ 66 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + V GGI++ +D A +L+ GA+++ I S A+ D ++ +++G Sbjct: 67 TALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYGA 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V+ +D DA K + +G + + V+ E +++ Q G ++ +++D Sbjct: 127 EKFVLALDVNIDASGQK--IIAISGWQEASGVSLEEL---IEDYQVVGLQHVLCTDISRD 181 Query: 183 GVRNGYDLEQLKKVREVC----HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 G G ++ RE+C + +SGG G+++ ++A + V G + + Sbjct: 182 GTLAGSNVNLY---REICAKYPKIHFQSSGGIGSLDD-IKALKGTGVSGVIVGRALLEGK 237 Query: 239 INIGE 243 N+ E Sbjct: 238 FNVAE 242 >UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZT22_9SPHI Length = 239 Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 98/218 (44%), Gaps = 12/218 (5%) Query: 31 DIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAA 90 D + +A++YA+EG L D+ + G + V ++A ++ GGIK+ E Sbjct: 32 DPIEMAQKYADEGFQRLHVVDLDGAKSGAPKHLALVEQMAAKTNLTIDYGGGIKTTEQVQ 91 Query: 91 KILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDES 150 +L GA +I S A+ P + FG I++ D + K +N + DES Sbjct: 92 AVLDAGAAMANIGSLAVKQPEVFKGWLQTFGSDKILLA----SDVKGEKIAINAWQ-DES 146 Query: 151 RTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVRE-VCHVPLIASGG 209 + D++ + G + +++DG+ G LE K+++ + +IASGG Sbjct: 147 EVSI-----YDFIADFIPSGLTQFFCTDVSKDGLLQGVALELYCKLKQKFPTMTIIASGG 201 Query: 210 AGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAY 247 +M+ +E +DG + ++ I + ELK + Sbjct: 202 VASMQD-IEDLNKEGIDGVIVGKAIYENRIALEELKQF 238 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 62.4 bits (150), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 60/246 (24%), Positives = 111/246 (45%), Gaps = 15/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DG+ V+ + F +I D V AK+Y L D+ + G+ V+ Sbjct: 2 IFPAIDLQDGRSVRLYKGDFAQETVINPDPVDQAKQYEAAKVGALHLVDLDGAKAGKPVN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V V + GGI+ E LS G D++ + S AL +P L ++ +G Sbjct: 62 VDIVKAVRAAFTGILEIGGGIRDKEAVDLYLSLGVDRVILGSVALKNPKLTKQVIAEYGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+G+ D + GK + D+S +T D + + + GA ++ +++D Sbjct: 122 EHIVIGV----DGKNGKVAAEGWL-DQSDVPMT-----DLIGAMIEGGAKYFIVTDVDRD 171 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + E L + +E ++ASGG +E +++ V ++ ++ I + Sbjct: 172 GTMQGANEELLGNLQKEFPTARIVASGGVRNLED-IKSLEQKGVMDSIVGKALYEGTITL 230 Query: 242 GELKAY 247 E+ Y Sbjct: 231 EEIGEY 236 >UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_LACLS Length = 246 Score = 62.0 bits (149), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 48/240 (20%), Positives = 110/240 (45%), Gaps = 15/240 (6%) Query: 6 IIPCLDVRDGQVV---KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+++G+ V KG + + + +A+++ + GA L D+ + G+ + Sbjct: 3 IIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQTRN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKIL-SFGADKISINSPALADPTLITRLADRFG 121 V ++ + ++ + GGI++L+ + L G +++ + + A P + L ++G Sbjct: 63 LEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + IVVG+D + T L ++++++K G +++ +++ Sbjct: 123 LSRIVVGVDIR----------EGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISK 172 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G + E ++ + + +I SGG A D+D G + +++ IN+ Sbjct: 173 DGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRA-ADSDFYGIIVGKAYYEGKINL 231 >UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Deinococci RepID=C1CY68_DEIDV Length = 251 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 106/237 (44%), Gaps = 15/237 (6%) Query: 3 AKRIIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 A IIPC+D++ G+ V+ G R + A+ + E GA + D+ A++ GR Sbjct: 16 APLIIPCVDIQSGRAVRLYEGDPERETVYFDSPLDAARHWVERGAGLVHLVDLDAAT-GR 74 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 ++ + ++ + +P V GGI+ E A +L G ++ I + A+ +P L+ L Sbjct: 75 GENREVIRQITSELGVPVEVGGGIRDREAAEDLLRAGVHRVVIGTAAVRNPQLVADLIAA 134 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G + +VV +D E + Q +G + + G ++ + Sbjct: 135 HGPERVVVSLDA-RGLEVATHGWAQGSG---------VNVAELTPGLADAGLELLIFTDV 184 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +DG G + E +++VR++ LI GG M+ + ++ ++GA+ ++ Sbjct: 185 TRDGTLKGLNRELMRQVRQLWINTLIVGGGVANMDD-VRLLQEERIEGAIVGRAIYE 240 >UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G189_ABIDE Length = 238 Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 49/246 (19%), Positives = 114/246 (46%), Gaps = 15/246 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSD 57 M A I P +D+ +G+VV+ ++ + I ++V A G + L D+ + + Sbjct: 1 MAAMIIFPAIDIYEGKVVRLLKGDYNKMTIYSENVVDKACEIEAAGGEWLHLVDLEGAKE 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G + ++V + + + + GGI++ K ++ G ++I + + A D + ++ Sbjct: 61 GNTPNFTYVEEICKKTGLKVEIGGGIRTEATIEKYINAGVNRIILGTKAATDKEFLNKMT 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 D++ + I VGID ++ + VT D+V E+++ G I++ Sbjct: 121 DKYR-EKIAVGIDVK----------DEKVAIKGWLEVTDKTIFDFVTELKEIGIKNIIVT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + +DG +G ++ +K+ + + + ASGG T++ + ++ + GA+ + Sbjct: 170 DIAKDGAMSGINVSFYEKLSKFTDMDITASGGVTTLDDLIR-LKNTGIYGAILGKAMYTG 228 Query: 238 IINIGE 243 +++ E Sbjct: 229 NVDLRE 234 >UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Alteromonadales RepID=HIS4_COLP3 Length = 261 Score = 61.2 bits (147), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/220 (25%), Positives = 104/220 (47%), Gaps = 25/220 (11%) Query: 6 IIPCLDVRDGQVVK-----GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ G+VV+ Q N++ + + YAE GA + F D+ + D Sbjct: 2 MIPAIDLIGGEVVRLYQGDYAQKTNYQYT--VQDRQQAYAESGATVMHFVDLDGAKDST- 58 Query: 61 VDKSWVSRVAEVIDIP---FCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 K + + V++ P V GG++ +D ++L+ GAD++ I S A+ P L+T+ Sbjct: 59 --KRQLKTLKTVVNHPSMIIQVGGGVRCEDDVKQLLALGADRVVIGSLAIKQPELVTQWV 116 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +G + IV+ +D DA+ K ++S + D + + Q G ++ Sbjct: 117 KTYGCEKIVLALDIKIDAQGNKTLPTHGWIEDSGVNLE-----DLLAQYQDAGIKHVLCT 171 Query: 178 MMNQDGVRNGYDLEQLKKVREVC-HVPLI---ASGGAGTM 213 +++DG G +++ EVC P I ASGG G++ Sbjct: 172 DISKDGTLTGTNVDLYS---EVCAKYPDIDWQASGGIGSL 208 >UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Planctomycetaceae RepID=A6C5Q1_9PLAN Length = 246 Score = 61.2 bits (147), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 99/215 (46%), Gaps = 17/215 (7%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+R G+ V+ Q + + GD +A+R+A+ GA L D+ + G+ V+ Sbjct: 3 ILPAIDIRGGKCVRLRQGDYGQETVFGDDPTEMARRWADGGAQRLHLVDLDGAKAGQPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKIL-SFGADKISINSPALADPTLITRLADRFG 121 V ++ E + +P + GGI+ +L G D++ + + AL DP ++ R+ Sbjct: 63 HEVVRKIVEAVSVPCQMGGGIRDEASIQLMLDEVGIDRVIVGTQALKDPQWFKQMVQRYP 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + + +G+D + E V++ +D +E ++ + Sbjct: 123 NR-LALGLDAR----------DSKVATEGWLDVSETSAIDLAKEYVGVELAAVIYTNIAN 171 Query: 182 DGVRNGYDLEQLKKVREVCH--VPLIASGGAGTME 214 DG+ G D ++ + + +P+IASGG T++ Sbjct: 172 DGMMQGVDEGTIQDMIALAELGLPVIASGGVTTLK 206 >UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=142 Tax=cellular organisms RepID=HIS4_METNO Length = 253 Score = 60.8 bits (146), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 98/212 (46%), Gaps = 14/212 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+++G+ V+ VQ + I D A +AE+G L D+ + G ++ Sbjct: 6 LFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFAGAPMN 65 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + IP + GGI+ + L+ G ++ I + A+ DP + R A R Sbjct: 66 AAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFV-REAARLFP 124 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VGI DA+ G+ V + ++T E L + + G ++ + +D Sbjct: 125 GRIAVGI----DAKDGRVAVEGW----AKTSTVTAEELG--RRFEDAGVAALIYTDIARD 174 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 GV G ++ + + +P+IASGG ++E Sbjct: 175 GVLKGLNIPMTLALAQAVSIPVIASGGLASIE 206 >UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TG14_METVO Length = 148 Score = 60.8 bits (146), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 57/96 (59%) Query: 35 LAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILS 94 +AK + E GA+ L D+ + DG V+ V ++ + +P + GGI+++ED ++++ Sbjct: 9 IAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIEDVEELVN 68 Query: 95 FGADKISINSPALADPTLITRLADRFGVQCIVVGID 130 G +++ I + A+ +P + +LA + G + I+V +D Sbjct: 69 LGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVALD 104 >UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Legionella pneumophila RepID=HIS4_LEGPL Length = 239 Score = 60.1 bits (144), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 52/230 (22%), Positives = 107/230 (46%), Gaps = 16/230 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG-DIVPL--AKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ Q R ++ + P+ A +A+ GA L D+ + G++ Sbjct: 3 VIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + I GGI+S+E A + + G ++ I S A+ +P L ++ ++ Sbjct: 63 LELICSMQKT-GIAIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIKP 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+ +D D + +N G ++ + + WE + + + G I+ + D Sbjct: 122 ENIVLALDVRVDTKVPLLAIN---GWQNNSTSSLWEVVSY---YENHGIKHILCTDIACD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 G+ NG + + ++ E + P IA +G + H +D G+L S Sbjct: 176 GMMNGPNFDLYQQAVE--YFPQIAWQASGGIRH----MQDITTLGSLGIS 219 >UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=21 Tax=Bacteria RepID=HIS4_XYLF2 Length = 269 Score = 60.1 bits (144), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 95/209 (45%), Gaps = 9/209 (4%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P LD+R+G VV+ G R ++P A+ +A+ GA + D+ A+ G Sbjct: 5 VYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYTL 64 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + GG++S +D A+IL GA ++ I S A+ T + FG Sbjct: 65 APLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFGP 124 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I V +DT DA G + + + T V + Q+ G ++ + +D Sbjct: 125 ERITVALDTRQDA-GGVWRLPVH----GWTEVAEATLEALAQQYAAAGLRHLLCTDIARD 179 Query: 183 GVRNGYDLEQLKKVRE-VCHVPLIASGGA 210 G+ +G +++ +R V V + SGGA Sbjct: 180 GMLSGPNMDVYAYLRALVPAVQIQVSGGA 208 >UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=B4W8G6_9CAUL Length = 243 Score = 60.1 bits (144), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 104/236 (44%), Gaps = 11/236 (4%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG-DIVPLAK--RYAEEGADELVFYDITASSDGRVVD 62 I P +D++DG V+ + + ++ D P + +A EGA+ + D+ + G V Sbjct: 3 IYPAIDLKDGVCVRLMHGKFDQVTRYDEQPATRLSAFAAEGAEWIHVVDLDGAEAGEAVQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + + ID+ GG++S D AK+L G ++ + S A+ P + FG Sbjct: 63 HALIGELTKAIDVKIQSGGGVRSANDVAKLLDTGVSRVVVGSLAVTQPNDVAAWLKGFGA 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I + D E G V G + V W LD K +++ + +D Sbjct: 123 EHITLAFDV--KIEDG-VPVPALKGWTQSSGVDLWTALD---RYPKGLFKHLLVTDVGRD 176 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 G G +LE L ++ R + L ASGG +++ + A + +GA+ ++ Sbjct: 177 GAMTGPNLELLAEIRRRRPDLVLQASGGVSSLDD-IAAVKSLGCNGAIVGRALYEN 231 >UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomycetales RepID=D2Q1W2_9ACTO Length = 256 Score = 59.7 bits (143), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 103/213 (48%), Gaps = 15/213 (7%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +DV DGQ V+ VQ + GD + A + E GA+ + D+ A+ GR ++ Sbjct: 18 LLPAVDVADGQAVRLVQGEAGSETSYGDPLAAATAWQEAGAEWIHLVDLDAAF-GRGSNR 76 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ V +D+ ++GGI+ E L+ GA +++I + AL DP R+ +G + Sbjct: 77 ELLADVTGRLDVQVELSGGIRDDESLEAALATGARRVNIGTAALEDPEWCDRVIQTYGDR 136 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + +G+D + + GD +E L + +++ G V+ + +DG Sbjct: 137 -VAIGLDVRGRTLAARGWTKE-GGD-------LYEVL---ERLERAGCERYVVTDVTKDG 184 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF 216 + G +L+ + + P++ASGG +++ Sbjct: 185 MLQGPNLDLYRDLCARTAKPIVASGGVSSLDDL 217 >UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Faecalibacterium prausnitzii M21/2 RepID=A8S9L9_9FIRM Length = 239 Score = 59.7 bits (143), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 53/218 (24%), Positives = 95/218 (43%), Gaps = 15/218 (6%) Query: 5 RIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+R GQVV+ Q + + G D A+ + GA L D+ + DG + Sbjct: 2 QLFPAIDLRGGQVVRLTQGDYDRMTVYGQDPCAQARSFVAAGAKNLHVVDLDGAKDGTLS 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++ +A+ + V GGI++ E K LS G + + S A+ D R+ ++G Sbjct: 62 NYDTIAALAKQGGLYIEVGGGIRTEERIEKYLSLGVGRCILGSVAVTDFAFTARMLQKYG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I VG+D + Y V+ + + + + + G I+ + Sbjct: 122 DK-IAVGVDAK----------DGYVAIHGWKEVSAEPGVAFCKRLAEAGCTAIIYTDIAC 170 Query: 182 DGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLE 218 DG G +L +++ EV V ASGG + LE Sbjct: 171 DGAMQGTNLSLYRQLAAEVPGVAFTASGGISSEAELLE 208 >UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFDF6 Length = 236 Score = 59.3 bits (142), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 43/220 (19%), Positives = 105/220 (47%), Gaps = 14/220 (6%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 RI P +D+++GQ+V+ + + ++ D + + + +EGA L D+ + G + Sbjct: 2 RIFPAIDIKNGQIVRLTEGKYDQVKVYSKDPEEVLEHFTKEGATALHIVDLDGAKSGTIE 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +++ + + + + GGI+ L+ G D++ + + A+ +P + + ++ Sbjct: 62 NQNTIKTILKNRHFVTQLGGGIRDESTINHYLNMGVDRVILGTVAVENPKFVEEMVKKYD 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q I VG+ D + G+ N + + ++ + +++ + + G I+ +++ Sbjct: 122 QQ-IAVGV----DEKDGQVRANGWLVN------SKVDAIEFCKMLTAMGVATIIYTDISK 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR 221 DG+ G D+ +++ + V +IASGG ++ E R Sbjct: 171 DGMMAGCDMASYRQLCKDRKVNIIASGGVTSIAEIKELKR 210 >UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Deinococcus RepID=HIS4_DEIGD Length = 243 Score = 59.3 bits (142), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 101/216 (46%), Gaps = 14/216 (6%) Query: 2 LAKRIIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 L IIPC+D++ G+ V+ G R + A+ +A GA + D+ A++ G Sbjct: 8 LQPLIIPCVDIQSGRAVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDAAT-G 66 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R +++ ++++ + +P V GGI+ A +L G ++ I + A+ +P L+ L Sbjct: 67 RGENRAVITQITAELGVPVEVGGGIRDRAAAEALLDAGVGRVVIGTAAVKNPALVRELIA 126 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G +VV + DA ++ + + S V + L + + G ++ Sbjct: 127 AHGPSRVVVSL----DARGLDVAIHGWA-EGSGVSVAELAPL-----LAEAGLETLIFTD 176 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 + +DG G D + +++VR++ LI GG T++ Sbjct: 177 VTRDGTLRGLDRDLMRQVRQLWSNTLIVGGGVATLD 212 >UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=2 Tax=Pedobacter RepID=C6Y3G6_PEDHD Length = 249 Score = 58.9 bits (141), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 59/257 (22%), Positives = 117/257 (45%), Gaps = 25/257 (9%) Query: 6 IIPCLDVRDGQVVKGVQF-RNHEIIGD--IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ DG+VV+ + N + + D I + + Y G + + D+ + G + Sbjct: 3 IIPAIDILDGKVVRLTEGDYNQKTVYDVSIAEMIETYRSNGTEFIHIIDLNGAK-GDFSN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + V + D+ GGI++++ +L G ++ + + A+ +P + L+ G Sbjct: 62 QKALFEVIKKTDMRVQYGGGIRTIKQVTDLLDAGIHRVIVGTQAITNPDFLQELSKEVGK 121 Query: 123 QC-----IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + IV+ ID + V +Y+G + + + +D+V + + G + Sbjct: 122 KYDYANRIVIAIDVLDE-------VIKYSGWMESSPI---KLMDYVDKCLQLGFFRFLCT 171 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVP---LIASGGAGTMEHFLEAFRDADVDGALAASVF 234 +N+DG G +E KK+ E H P LIASGG +M+ +E D+ + Sbjct: 172 DINKDGKLGGAAVELYKKLLE--HSPFIKLIASGGVSSMKD-IEELDKYDIRSVVVGKAI 228 Query: 235 HKQIINIGELKAYLATQ 251 ++ I I ++K + Q Sbjct: 229 YENRITIDQIKEWNLKQ 245 >UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3 Tax=Clostridiales RepID=C4Z9Z2_EUBR3 Length = 427 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 62/126 (49%), Gaps = 2/126 (1%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 K I+ L +++GQ VK + ++GD+ L + Y + G D+++ +D++ D + Sbjct: 5 KNIVATLYLKNGQAVKSAS--DMTVMGDVYNLCQLYNDSGIDKIIIFDLSTDDDEHEKNI 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + IDI C G I +ED K+L G ++ N+ + L +++FG Sbjct: 63 HTIENINRNIDIKVCAGGNINRIEDVKKLLYAGCLQVIFNATKDSSLELANVASEKFGKD 122 Query: 124 CIVVGI 129 I++ I Sbjct: 123 KILLSI 128 >UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_ANADF Length = 238 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/240 (22%), Positives = 106/240 (44%), Gaps = 17/240 (7%) Query: 6 IIPCLDVRDGQVV---KGVQFRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IP +D+ G+ V KG F + A+ +A GA L D+ + G V Sbjct: 3 VIPAIDLMGGEAVRLEKG-DFATKTVYARHPAEKAEEFARAGATLLHVVDLDGAKAGWPV 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V + EV I + GG++SL D K+L+ G + + + A+ L+ + RF Sbjct: 62 NLDAVRAICEVPGIEVELGGGLRSLPDIEKVLALGVRYVVLGTAAVERLGLVEQACQRFP 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q + DA G+ + + T +D ++V+ G G + + + Sbjct: 122 GQ-----VRAGIDARNGEVKIAGW------LEGTGLAAVDVARKVKGAGVGLVEYTDVAR 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG+ G D +++ +P++ASGG +++ + A R A + G + +++ I++ Sbjct: 171 DGMFTGVDAAGAARIQAEAGIPVVASGGVASLDD-VTACRAAGLAGVIVGKALYERRIDL 229 >UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ6_9ACTN Length = 247 Score = 58.5 bits (140), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 120/258 (46%), Gaps = 22/258 (8%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITAS----SDG 58 + P +D+ G+VV+ G + R D V +A+ +AE+GA + D++++ D Sbjct: 3 LFPAIDLIGGKVVRLERGDRSRCKVYSDDPVAVARSFAEQGASWVHVVDLSSAFGEDEDT 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + + + V + V GG++SL ++ +GA +I++ + + +P A Sbjct: 63 CAANSAAIKAICGVDGLSVDVGGGVRSLARIDELAGYGARRIALGTVLVTEPGFAEVAAQ 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG + +V I A G+ VN + D + + D V ++ + G +V Sbjct: 123 GFG-ELLVADIA----ARDGQVKVNGWR-DGAGVALD-----DAVAQLSELGFKHLVYTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHK 236 + +DG++ G D+ + V EV P++ASGG ++ L A + ++GA+ ++ Sbjct: 172 IARDGMQTGIDVAAYRHVAEVAGFPVVASGGISALDDIRALAAVGEGAIEGAITGRALYE 231 Query: 237 QIINIGELKAYLATQGVE 254 N +A A +G E Sbjct: 232 G--NFTLAQALAAARGEE 247 >UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=HIS4_BUCCC Length = 245 Score = 58.5 bits (140), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/219 (21%), Positives = 95/219 (43%), Gaps = 21/219 (9%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD G++V+ Q + I DI ++Y +GA + D+ ++ Sbjct: 2 IIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 KS + + ++ F V GGI+S D + G KI I + A+ P + +G Sbjct: 62 KSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGS 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETL------DWVQEVQKRGAGEIVL 176 + V+ +D +N T E++ + W+ D +++ G I+ Sbjct: 122 KNFVLSVD-----------ININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILC 170 Query: 177 NMMNQDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTME 214 +++DG +G ++ K ++ + ++ L +SGG ++ Sbjct: 171 TDISRDGTFSGPNISLYKYLKNKFPNIVLQSSGGINSIS 209 >UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQP1_9RICK Length = 238 Score = 58.5 bits (140), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/247 (18%), Positives = 111/247 (44%), Gaps = 14/247 (5%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DG+ V+ + F + + AK + ++G + L D+ + + Sbjct: 3 IYPAIDLQDGKCVRLTKGDFEQQTVYSRSPIEQAKAFEDKGFEFLHVVDLDRTIHKEKSN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + + V GG+++ + +++ G + + + A+ DP L+ ++ ++ Sbjct: 63 LKTIKEIIQSTGLKVQVGGGLRTKDTVEEVIDLGVENAVMGTAAVNDPDLLIEISQKYKN 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I VG+D K +Q T+ D+++ ++ I+ +N+D Sbjct: 123 K-ISVGLDVRDKMIALKGWKDQ----------TEISCFDFLETIKNLPLKSIIFTDINKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G++ G +++ K+ E ++P+ ASGG +++ + G + + +I++ Sbjct: 172 GMKQGINIDDTLKMAESSNIPVTASGGVSSIDDIKLIKSKKKISGVVVGKAIYDGLIDLN 231 Query: 243 ELKAYLA 249 EL + A Sbjct: 232 ELVKFNA 238 >UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBX0_9FIRM Length = 234 Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 44/242 (18%), Positives = 113/242 (46%), Gaps = 15/242 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+RD + V+ Q + + D +A+ + + G L D+ A+ G++ + Sbjct: 3 IFPAIDIRDNKCVRLSQGDYDKQTVYFDNPFTVAEDFEKRGVKYLHIVDLDAALIGKLTN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ ++ V GGI+ E K + G D++SI + A+ D + +++++ Sbjct: 63 FDIIKKIITDTNMLIEVGGGIRGEEQIKKYVDIGVDRVSIGTKAVKDFAFLKEMSEKYPY 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I D + ++ ++ + + W+ LD ++++ G IV+ + +D Sbjct: 123 K-----ISLSLDVKDEYVYIKGWS---ENSGILIWDYLDKIKDLPLTG---IVVTDIKKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ +G E +K+++ ++ SGG +++ + ++ D G + ++ ++ Sbjct: 172 GMLSGPSFELYRKLKKATKHNIVVSGGVSSLDD-INKLKEDDTYGVIVGKALYENKFSVE 230 Query: 243 EL 244 ++ Sbjct: 231 DI 232 >UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CARHZ Length = 243 Score = 57.4 bits (137), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 100/216 (46%), Gaps = 18/216 (8%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ +VV+ G + R E V LA +Y E GA + D+ + G + Sbjct: 3 LIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL--ADRF 120 ++ + + + IP V GGI+ +E +++ G ++ + + A+ +P L+ + DR Sbjct: 63 FEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEMLTLDR- 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + VGI DA+ G + + ES + + LD +V++ G I+ + Sbjct: 122 --DKVAVGI----DAKNGWVAIKGWV--ES----SNYRALDLAYKVKEMGVTTIIYTDIA 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF 216 +DG G + + K+ + +IASGG +E Sbjct: 170 RDGSLTGPNFNETLKLAIDTGLKVIASGGISGLEDL 205 >UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Nannocystineae RepID=D0LIZ1_HALO1 Length = 239 Score = 57.0 bits (136), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 91/215 (42%), Gaps = 18/215 (8%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +I P +D+ G VV+ Q + E + + + +R+A GA+ + D+ + G Sbjct: 2 KIYPAIDLLGGNVVRLHQGKRSEALVYSNEPAEIVRRFASAGAERVHVVDLDGAFSGERA 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++ +A +P V GGI+ + + GA + + A+ +P R A Sbjct: 62 HREALAEMAAASPVPLQVGGGIRDRAALEAVFATGAGFAVLGTAAVKNPAF-AREACAAH 120 Query: 122 VQCIVVGIDT--WYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 C++V +D A G T +E R W GA ++ + Sbjct: 121 PGCVIVAVDARDGVVAIEGWVESAGITAEELGKRAADW------------GAAGLLYTDV 168 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 +DG + G ++ + + +P+IASGG GT++ Sbjct: 169 MRDGAQVGPNIATTAALAQAVDIPVIASGGVGTLD 203 >UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RFK6_LEGLO Length = 246 Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 113/250 (45%), Gaps = 17/250 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG-DIVPL--AKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ Q + ++ D+ P+ A +A+ GA L D+ + G + Sbjct: 3 LIPAIDLQAGRCVRLRQGQFDQVTQFDMSPIDRASYFAKLGAKRLHIVDLDGAKIGTMQQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + GGI+SLE A S G + I S A+ DP L T++ + Sbjct: 63 LPLICTMQHT-GVTVQAGGGIRSLEQAKTCYSAGISLLVIGSIAITDPGLTTKIINEISP 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++ +D + K + G ++ + + WE + + Q++ G +I+ + D Sbjct: 122 KNIILALDIRME---NKIPLPATHGWQTTSTMNLWEVVSFYQQL---GITQILCTDIASD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIIN 240 G+ G + + ++ E P IA +G + H + + + A+ ++ + N Sbjct: 176 GMMQGPNFDLYQEAVE--RFPNIAWQASGGIRHQDDINKLQKLGIKAAILGLTMYQDVFN 233 Query: 241 IGELKAYLAT 250 LK+ L++ Sbjct: 234 ---LKSILSS 240 >UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=17 Tax=Epsilonproteobacteria RepID=HIS4_CAMHC Length = 236 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/242 (19%), Positives = 107/242 (44%), Gaps = 16/242 (6%) Query: 5 RIIPCLDVRDGQVV--KGVQFRNHEIIGDIV-PLAKRYAEEGADELVFYDITASSDGRVV 61 I+P +D+++G V K + + +I D LA+++A+ GA L D+ + G Sbjct: 2 EILPAIDLKNGFAVRLKKGEMNSAKIYSDKPWELAEKFADLGAKWLHIVDLDGAFAGEAK 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + ++ + ++ V GGI+ E + G + + S AL +P + ++A ++ Sbjct: 62 NAKTIEKIVKSTNLKIEVGGGIRDEERIKFYKNSGVSRFILGSAALKNPEFVKQMAKKYK 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 I VGID N + E V+ + + + G I+ +++ Sbjct: 122 ---IAVGIDA----------KNGFVATEGWAEVSNIKACELAKIYADAGVEAIICTDISK 168 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG+ +G +++ +++ + + IASGG + + + G + +++ I++ Sbjct: 169 DGMLSGVNVKFSEEIAKSSGIKTIASGGVKDLSDIKALKQSGKIYGVIVGKAYYEGSIDL 228 Query: 242 GE 243 E Sbjct: 229 KE 230 >UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alteromonadales RepID=HIS4_PSEHT Length = 242 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 36/132 (27%), Positives = 63/132 (47%), Gaps = 11/132 (8%) Query: 6 IIPCLDVRDGQVVK-------GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 IIP LDV Q+V+ VQF E+ + K YA+ GA +L D+ + D Sbjct: 2 IIPALDVLQNQIVRLYQGKYETVQFYPFELGARL----KEYADSGAGKLHLVDLEGARDP 57 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + +++P+ V GGI+ +D + L GA+++ I S A+ + + Sbjct: 58 SKKQWQHIQAATKALNVPYQVGGGIRCEQDVSDWLKAGANQVVIGSMAVEKREQVKAWIE 117 Query: 119 RFGVQCIVVGID 130 +FG + V+ +D Sbjct: 118 QFGAEHFVIALD 129 >UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Dictyoglomus RepID=HIS4_DICT6 Length = 242 Score = 55.1 bits (131), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/216 (22%), Positives = 98/216 (45%), Gaps = 16/216 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ +VV+ + +I+ + + LAK + E+GA L D+ ++ D Sbjct: 3 IIPAIDIYKHKVVRMETGKKEKIVLEFNNPLDLAKYWEEKGAKALHLIDLQSAIDANDES 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 KS V + + IP V GG +S E + +S+G ++ ++S + + L ++ Sbjct: 63 KSIVRDIVRSVSIPVEVGGGYRSREKIEEAISWGVWRVIVSSILGMELDYLLDLFSKYE- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I+ ID WYD + G + +W + +++ E++ +++D Sbjct: 122 NKIIPSID-WYDGKVGIKGWQDF---------IEWRDIK--RKIDLLKVREVIFTDISRD 169 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 G G +LE +K + + +GG ++E ++ Sbjct: 170 GTLKGVNLENIKNFLSLHDYDVWIAGGISSIEDVIK 205 >UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Archaeoglobaceae RepID=HIS4_ARCFU Length = 238 Score = 53.9 bits (128), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 48/237 (20%), Positives = 113/237 (47%), Gaps = 17/237 (7%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+IP +D++DG+VV+ Q + E+ + + +AK++ E GA L D++ + GR+ Sbjct: 3 RVIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRLR 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++ +A++ ++ V GGI+ A ++ G D++ + A+ + A ++ Sbjct: 63 HEEIIAEIAKMAEVQ--VGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKWK 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +V D++ G+ V + T V E D + + ++ Sbjct: 121 GRVMVA-----IDSKKGRVAVKGWKEVVELTPVQLAELYDDLDV-------SFLYTNIDV 168 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 +G+ +G + E++++V + P+ +GG ++E A R + ++++ K++ Sbjct: 169 EGLVSGIERERIEEVVKSLRNPVYVAGGISSIEDIRFAKRVGAAGVVIGSALYTKKL 225 >UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=117 Tax=Enterobacteriaceae RepID=HIS4_BLOFL Length = 251 Score = 53.5 bits (127), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 48/247 (19%), Positives = 106/247 (42%), Gaps = 18/247 (7%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP LD+ +G V+ Q +++ G+ + Y ++GA + D+ + + + Sbjct: 2 IIPALDIINGDAVRLYQGKYQSQSHYGNPYSILSTYVQQGATMIHLVDLDGARNPKNRQL 61 Query: 64 SWV---SRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 S + + A + + GGI+ D +L FG +++ + S A+ P + + F Sbjct: 62 SLIKELTHTAITSHLKIQIGGGIRHATDIKTLLKFGVNRVILGSIAITHPKKVKQWFTYF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 +V+ +D + D++ + V G + T + E ++ V G ++ ++ Sbjct: 122 NPSSLVLALDIYIDSKNNRKVVIH--GWQKETNIQLEEVIENYNSV---GLKHVLCTDIS 176 Query: 181 QDGVRNGYDLEQLKKVREVCH----VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +DG G ++ + +C+ + ASGG + L+ R + V+ + F + Sbjct: 177 KDGTLLGSNINLY---QSICYKWPKISFQASGGVAKLTEILQ-LRSSGVNSIIIGRSFLE 232 Query: 237 QIINIGE 243 + + E Sbjct: 233 KKFTLTE 239 >UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Leptospira RepID=HIS4_LEPBL Length = 241 Score = 53.1 bits (126), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 50/218 (22%), Positives = 99/218 (45%), Gaps = 17/218 (7%) Query: 6 IIPCLDVRDG---QVVKGVQFRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 IIP +D+ D ++ KG ++ +I + LA+ +A+ GA L D+ + + + Sbjct: 3 IIPAIDLFDNCAVRLFKG-NYKEKKIYSSEPWKLAEGFAKNGATLLHLVDLNGARNQLGI 61 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 ++ + ++ + + + GGI+ E A G D+ + + A+ DP L+ D + Sbjct: 62 NEDSILKIRKTTSLKVQLGGGIRDKEKLAYYDKIGIDRFILGTAAVTDPDLLKFALDNYE 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDES-RTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + +VV + DA G + + D R R D + + K G IV + Sbjct: 122 KERVVVAV----DAIDGIVKIAGWEKDSGVRYR-------DLMDRLAKAGIEHIVFTDIA 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 QDG G +L+ +++ +IASGG +++ ++ Sbjct: 171 QDGTLAGPNLKAYQEILNSYPFQVIASGGISSLKDLMD 208 >UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Proteobacteria RepID=HIS4_DESOH Length = 251 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/243 (23%), Positives = 109/243 (44%), Gaps = 16/243 (6%) Query: 6 IIPCLDVRDGQVVKGVQF-RNHEIIGDIVP--LAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ +Q N E + P +A+R+AE GA+ + D+ + + + Sbjct: 3 VIPAVDIKGGKCVRLLQGDMNAETVFSDDPGAMAERWAEAGAELIHVVDLDGAIEKSPRN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S + + +P V GGI+ ++ G +I I S A+ P L+T F Sbjct: 63 LKAISALIRRVGVPVQVGGGIREIDTVKMYADLGVARIVIGSAAVNHPDLVTAACREFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+GI DA G+ E T T D + G I +++D Sbjct: 123 R-IVLGI----DARDGRVAT------EGWTSTTDIAAADLAARFEGCGVAAINFTDIHRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIIN 240 G+R G ++ ++ +P++ASGG T++ L ++ V G + + ++ Sbjct: 172 GMRTGPNIPAIEAFARATAIPVVASGGVSTIDDIQALLGIQEFGVTGVITGRALYDGTLD 231 Query: 241 IGE 243 + E Sbjct: 232 LAE 234 >UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermotogaceae RepID=HIS4_THEP1 Length = 241 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/252 (19%), Positives = 110/252 (43%), Gaps = 25/252 (9%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++P +D+ G+V + V+ + I D L K+ EEG + D++ + + V + Sbjct: 3 VVPAIDLFRGKVARMVKGKKENTIFYEKDPAELVKKLIEEGFTLIHVVDLSKAIENSVEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R++E + + GGI+S + A ++ G + ++S L DP+ + L + Sbjct: 63 FPVLERLSEFAE-HIQIGGGIRSFDYAERLRKLGYKRQIVSSKVLEDPSFLKFLKE---- 117 Query: 123 QCIVVGIDTWYDAET--GKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + ++ + +T GK + +E + + + ++ +++ G EIV + Sbjct: 118 ----IDVEPVFSLDTRGGKVAFKGWLAEE------EIDPISLLKRLKEYGLEEIVHTEIE 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-----DADVDGALAASVFH 235 +DG +D +K+ V + A+GG + A R + + G + F Sbjct: 168 KDGTLQEHDFSLTRKIAIEAEVNVFAAGGISSENSLKTAQRVHRETNGLLKGVIVGRAFL 227 Query: 236 KQIINIGELKAY 247 + I+ + +K Y Sbjct: 228 EGILTVEVMKRY 239 >UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=cellular organisms RepID=HIS4_THEON Length = 229 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 60/243 (24%), Positives = 106/243 (43%), Gaps = 24/243 (9%) Query: 5 RIIPCLDVRDGQVVKGV--QFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 RI P +D+ G+ V+ Q ++ GD V +A R+ E D++ D+ + G+ + Sbjct: 2 RIYPAIDLMGGKAVRLYRGQKEKVKVYGDPVEIASRFTEL-VDKIHVVDLDGAFTGKPQN 60 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V + E + V GG +S E AK GA+ + I + A D + ++ D F Sbjct: 61 LDVVKEIIEETGLKVQVGGGFRSYESIAKAYEIGAENVIIGTKAF-DLEFLEKITDNFD- 118 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 GI DA GK V + +ES +V E + ++E R + + +D Sbjct: 119 -----GITVSLDARGGKIAVKGWL-EESSLKVG--EAYEMLREYVDR----FIYTSIERD 166 Query: 183 GVRNGYD-LEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + +E+ K E I +GG +++ L+ R GA+ ++ +++ Sbjct: 167 GTLTGIESIERFWKDEE-----FIYAGGVSSVDDVLK-LRRVGFSGAIVGKALYESEVSL 220 Query: 242 GEL 244 EL Sbjct: 221 KEL 223 >UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V5Z6_9AQUI Length = 119 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 64/117 (54%), Gaps = 3/117 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNH--EIIGD-IVPLAKRYAEEGADELVFYDITASSDG 58 L + IIP +D+++G+ V+ + + ++ GD V +AKR+ E+GA L D+ + +G Sbjct: 3 LKEFIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHIVDLDGAFEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + V ++ + +++P GG+++ E K++ G +++ I S A D L + Sbjct: 63 IPKNYKIVEQIVKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDKELFEK 119 >UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=HIS4_BUCBP Length = 241 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 50/219 (22%), Positives = 96/219 (43%), Gaps = 11/219 (5%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII----GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 IIP +D+ +G +V+ Q N++ +I +A +Y +GA + D+ + Sbjct: 2 IIPSIDLIEGNIVRLYQ-GNYDTKTFYQNNIYDIALKYYNQGAKIVHLVDLDGALCPNNK 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 S + + + V GGI+S +D +L GA ++ I S A+ + T + + FG Sbjct: 61 QTSLIKNLLNYFNFHIQVGGGIRSYKDVETLLLNGAKRVVIGSSAINNITEVEKWLLEFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + IV+ +D + Y G ++R+ V+ L + G ++ + + Sbjct: 121 YKSIVLALDVY--VRNNGYKEVVINGWKNRSNVSLESVL---ERFSTLGIKYVLCTDVKK 175 Query: 182 DGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEA 219 DG G + K + ++ +V SGG GT+ + A Sbjct: 176 DGTCLGPNFTLYKNISKLFKNVCFQLSGGIGTISDVISA 214 >UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U8M5_HYDS0 Length = 234 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/243 (23%), Positives = 104/243 (42%), Gaps = 17/243 (6%) Query: 6 IIPCLDVRDGQVV--KGVQFRNHEII-GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D++DG VV K +F N ++ + + K + + G + D+ + G + Sbjct: 5 IIPAIDIKDGAVVRLKEGKFENVKVYRQNPIDQFKLFVDLGFTRIHIVDLDGAKVGIPKN 64 Query: 63 -KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 K + + D + GGI+SLE A + GAD I + + A+ D RL + + Sbjct: 65 LKLLEDMLKQKNDAKVEIGGGIRSLETAKALFEIGADYIIVGTLAVKDKEEFIRLLELYK 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I+ DA+ GK + + + S + D + + +N Sbjct: 125 DRIIL-----SVDAKNGKVAIGGWEEESSIS------PCDMARIYDNYPIESYLYTNINI 173 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G D+ K ++ P+IASGG ++E ++ V+G + ++ I+I Sbjct: 174 DGTLTGVDINPYKDFKKCTTKPIIASGGVASLEDVIKL--KTVVNGVVVGKAIYENKIDI 231 Query: 242 GEL 244 L Sbjct: 232 YNL 234 >UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Zymomonas mobilis RepID=HIS4_ZYMMO Length = 250 Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 88/207 (42%), Gaps = 14/207 (6%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+++G VV+ G R D A+++ E GA L D+ + G ++ Sbjct: 7 IFPAIDLKEGHVVRLSEGDMDRATIYDDDPAARARQFYEAGARYLHVVDLDGAFAGHAMN 66 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + + GGI+ + LS G ++ I + A +P L+ A ++ Sbjct: 67 AAAVDAIVKAFPGTIELGGGIRDMNAIDGWLSRGISRVVIGTAAFENPDLVKEAAQKYPG 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q +V DA G + ++S VT D + G ++ + +D Sbjct: 127 QIVVA-----VDARDGMVTTKGWA-EQSEISVT-----DMAERFADAGVVALLYTDVGRD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGG 209 G++ G + E + +P+IASGG Sbjct: 176 GLKKGCNSEATLALAAATDIPVIASGG 202 >UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=HIS4_THENN Length = 248 Score = 52.4 bits (124), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 60/255 (23%), Positives = 115/255 (45%), Gaps = 31/255 (12%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITAS---SDGR 59 +IP +D+ +VV+ V+ + I D + L ++ EEG + D++ + SD Sbjct: 3 VIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEESDEN 62 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + +S A+ I I GGI+ LE A K+L G + ++S L DP+ + +L + Sbjct: 63 LPVLEKLSSYADHIQI----GGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKLKE- 117 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTG--DESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +G++ + +T + V + G DE + + V +++ G EIV Sbjct: 118 -------IGVNPVFSLDTREGKV-AFKGWLDEK-----DIDPVFLVNRLKEFGLEEIVHT 164 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAG---TMEHFLEAFRDAD--VDGALAAS 232 + +DG +D +++ V +IA+GG ++E LE R + + G + Sbjct: 165 EIEKDGTLKEHDFSLTERIALETGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGR 224 Query: 233 VFHKQIINIGELKAY 247 F + + + +K Y Sbjct: 225 AFLEGTLTVEVMKRY 239 >UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01ZU7_SOLUE Length = 227 Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/235 (22%), Positives = 111/235 (47%), Gaps = 20/235 (8%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGDIV-PLAKRYAEEGADELVFYDITASSDGRVVDKS 64 I+PC+D+ DG+VV+ +Q R + GD + +R+A G E+ D+ A+ G+ + + Sbjct: 2 IVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRFA--GFPEIQVIDLDAAL-GKGSNDT 58 Query: 65 WVSRVAEVIDIPFC-VAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 V +A C V GG+++L+ A +LS GA ++ + + A + + Sbjct: 59 LVKMLASK---AVCRVGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPA 115 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 +V +D+ + G+ V + + T T E L ++ + ++++G Sbjct: 116 TTIVALDS----KGGRIVVKGW---QEATEFTAEEVLHSLEPY----CSGFLCTYVDKEG 164 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 + G DL+ ++R + A+GG T+E ++A ++ A+ +++ ++ Sbjct: 165 MMQGTDLDWFARLRAATAHEITAAGGITTLED-IKALLAMNIHTAVGMAIYTGRL 218 >UniRef50_Q9F8I8 Cyclase (Fragment) n=1 Tax=Carboxydothermus hydrogenoformans RepID=Q9F8I8_CARHY Length = 114 Score = 51.6 bits (122), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 37/51 (72%) Query: 155 TQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLI 205 T + ++W +EV++ GAGEI+L M++DG ++GYDLE +++ + +P+I Sbjct: 64 TGIDAVEWAKEVERLGAGEILLTSMDRDGTKDGYDLELTREIADAVKIPVI 114 >UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_SYMTH Length = 249 Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/246 (23%), Positives = 107/246 (43%), Gaps = 20/246 (8%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE--IIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D++DGQVV+ Q R E + G D V +A R+AE GA + D+ + GR + Sbjct: 5 LYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQN 64 Query: 63 KSWVSRVAEVI-----DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + V + E + + + GG+++LE L+ G + I + AL + + R Sbjct: 65 AAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSAL-EGDVAARAV 123 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 RFG + V ID + VT+ +D +++ G +V Sbjct: 124 ARFGPDRVAVSIDAR----------GGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYT 173 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + DG+ G + +L+ + + +IASGG ++E V GA+ + Sbjct: 174 DIATDGMLTGPNFAELEMMGR-TGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTG 232 Query: 238 IINIGE 243 +++ E Sbjct: 233 AVDLAE 238 >UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8V9_IGNH4 Length = 235 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 20/218 (9%) Query: 5 RIIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+ P +DV +G+ VK GV+ ++ GD V A+ +A EGA L D+ + G+ + Sbjct: 2 RVFPSIDVSEGRAVKRVRGVKGTGLDL-GDPVKWAEFWALEGAKGLHVVDLDGAEAGKPI 60 Query: 62 DKSWVSRV---AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + +++V A+ + VAGG++ +E + AD I S A DP + ++ Sbjct: 61 NVEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPK--ADAFVIGSRAHKDPEFLEVASE 118 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G ++V ID + GK V + + V E L+ + RG + Sbjct: 119 AVGADKVIVAIDL----KGGKVSVEGW---KEEIPVGLKEALEKFKGRSFRG---FLYTY 168 Query: 179 MNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEH 215 ++ +G G D+ +K + RE L +GG G+ EH Sbjct: 169 VDTEGTMEGPDVSGVKYIRREYPDKLLEYAGGVGSPEH 206 >UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=HIS42_PHOLL Length = 258 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 50/241 (20%), Positives = 103/241 (42%), Gaps = 20/241 (8%) Query: 6 IIPCLDVRDG---------QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 I P +D+ DG ++ +G +G +A + GA + D+ A+S Sbjct: 9 IFPSVDIVDGIAMTSNSAIRLTRGESSTLRRPLGTPAEVALAWQNAGAKWIHVVDLDAAS 68 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 GR + ++ V +DI V GGI+ K+L+ G ++++ + AL +P + Sbjct: 69 -GRGSNSHLIADVLAAVDINVQVCGGIRDETILRKVLATGCQRVNLGTAALENPDWCAQA 127 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 +G + I + +D +E + + + V++ D ++ + K+G V+ Sbjct: 128 IAEYGDK-IAIALDVKSTSEGYQLATHGWN-------VSKGNLWDLLERLDKQGCQRYVV 179 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVF 234 + + G+ + + L++V P+IA GG +++ L V+GA+ Sbjct: 180 TDVERGGMMSSPNFTLLQEVCAKTSSPVIAGGGVSSLDDLRALADLSTIGVEGAILGQAL 239 Query: 235 H 235 H Sbjct: 240 H 240 >UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB3_9BACT Length = 239 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 92/206 (44%), Gaps = 16/206 (7%) Query: 6 IIPCLDVRDGQVVK--GVQFRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+ +VV+ G F + GD V A +AE GA + D+ + G V Sbjct: 6 IYPAIDLYSRKVVRLTGGDFEKIKEYGDDPVETALSFAEAGARWIHLIDLEGAEKGSPVH 65 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +VA +P GG+++ ED A LS GA ++ + S L RFG Sbjct: 66 LKELEKVAASTGLPVQYGGGLRTEEDVALALSSGAKRVYLGSLLFKGSP--RTLWKRFG- 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IV +D + G ++ + T VTQ + + E+ + G ++ +++D Sbjct: 123 NSIVPSVDV----KNGTVALSGW------TEVTQLPPEEAITELLRIGYSTFLVTSVSRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASG 208 G +G DL+ +++++ L A G Sbjct: 173 GTASGPDLKLYERLKKTDGRILAAGG 198 >UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=4 Tax=Vibrio RepID=A6Y2G9_VIBCH Length = 262 Score = 50.4 bits (119), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 46/213 (21%), Positives = 95/213 (44%), Gaps = 16/213 (7%) Query: 29 IGDIVPLAKRYAEEGADELVFYDITASS----DGRVVDKSWVSRVAEVIDIPFCVAGGIK 84 +G++ +A+ + + GA + D+ A+S + R++ V +E + C GGI+ Sbjct: 37 LGEVFEVAELHFQSGAKWIHIVDLDAASGVGSNQRLI-MDLVKHFSEKVQTQVC--GGIR 93 Query: 85 SLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQ 144 S E + + G +++I+S P L +L ++G + I + +D + K Sbjct: 94 SNEILEQYILAGCSRVNISSMIFDKPKLCEKLLKKYG-EKIAIALDVKLVNQEYKLATRG 152 Query: 145 YTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPL 204 + + W TLDW + G VL +++ G N + L++V P+ Sbjct: 153 WNTLQGNL----WTTLDW---LDNSGCQRYVLTDVDRGGSLNHPNFSLLEQVLTKTSTPI 205 Query: 205 IASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 I+ GG +++ ++ ++GA+ + H Q Sbjct: 206 ISGGGLCSLDD-IDRLYQIGIEGAVLGQLIHTQ 237 >UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HIS4_RUBXD Length = 243 Score = 50.1 bits (118), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 58/244 (23%), Positives = 102/244 (41%), Gaps = 16/244 (6%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D++ G+ V+ Q R D V A+ + GA L D+ + +GR V Sbjct: 9 VFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPVQ 68 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +A +P V GGI++LED GA ++ + + A+AD R + G Sbjct: 69 LALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELGA 128 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +V DA G + + + ++ V E + R ++ +++D Sbjct: 129 DLVVA-----VDAREGVVATHGW---QRQSGVGAAELAGELAAEGVR---AVLFTDISRD 177 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G LE+ +V + +P IASGG R V GA+ + ++ + Sbjct: 178 GTGEGAALERTAEVAGI--IPTIASGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLE 235 Query: 243 ELKA 246 EL A Sbjct: 236 ELLA 239 >UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=1 Tax=Silicibacter lacuscaerulensis ITI-1157 RepID=D0CY30_9RHOB Length = 282 Score = 50.1 bits (118), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 38/131 (29%), Positives = 67/131 (51%), Gaps = 5/131 (3%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+ P +++++G+ V + R E + D V A+ +A GA+ + D A +GR Sbjct: 37 RVYPTMELQNGRCVTLDKGRLDEPMIWHVDPVETAQGWAAAGAEWMHLTDFDAI-EGRDT 95 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + V ++ ++P +AGG +S E + + GA +I I + A DP L LA + Sbjct: 96 NSALVEQIIRSAELPVQLAGGFRSREQVERWIDKGAGRIVIGTLAARDPHLFKELAKLYP 155 Query: 122 VQCIVVGIDTW 132 Q IV+ +D W Sbjct: 156 DQ-IVLAVDVW 165 >UniRef50_C6MNJ9 NADH:flavin oxidoreductase/NADH oxidase n=1 Tax=Geobacter sp. M18 RepID=C6MNJ9_9DELT Length = 348 Score = 49.7 bits (117), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 22/45 (48%), Positives = 30/45 (66%) Query: 74 DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 DIP V GGI++ ED +L G D ISI+ P +++P LITRL + Sbjct: 280 DIPVIVVGGIRNFEDMEAVLEAGVDMISISRPLISEPDLITRLKN 324 >UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW5_HODCD Length = 241 Score = 48.1 bits (113), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/214 (21%), Positives = 95/214 (44%), Gaps = 20/214 (9%) Query: 5 RIIPCLDVRDGQVVKGV--QFRNHEIIGDIVPL--AKRYAEEGADELVFYDITASSDGRV 60 R + +DV++G+ V+ Q + + PL +++ + D + D+ + G Sbjct: 2 RFLASIDVKNGECVRLCRGQMADCRVYAS-SPLEAVRKFNLQCCDLVHIVDLDGAVCGS- 59 Query: 61 VDKSWVSRVAEVIDIPFCV--AGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 ++W S + + CV GG+++L DA L GA K+ + + A+AD + ++ Sbjct: 60 -PQNWRSILEAARQLKGCVQVGGGVRTLADAKLYLEGGASKVVLGTSAIADMEFVCHVSW 118 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 + + + VG+DT+ + + T V+ V +++ ++ Sbjct: 119 LYPGR-VCVGVDTF----------GELVATDGWTAVSCVRCDQLVPKLEAARVSCLIWTD 167 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGT 212 +N+DG G + + L +V VP+I SGG T Sbjct: 168 INRDGTLQGVNFDALDRVLAASAVPVIVSGGVAT 201 >UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y7T0_9BACT Length = 237 Score = 47.8 bits (112), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 46/213 (21%), Positives = 93/213 (43%), Gaps = 16/213 (7%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+ GQ V+ G R +A +A +GA +L D+ + +G + Sbjct: 3 IYPAIDLYAGQAVRLQRGDYARMTVYSDRPETVAADFAAQGARQLHLIDLEGAKNGGTPN 62 Query: 63 KSWVSRVAEVIDIPFC-VAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V + + FC V GGI+S++ L G D++ + + A R R+G Sbjct: 63 LETIVAVKKSSGL-FCQVGGGIRSMDAIVAYLDAGVDRVILGTAAATQAHFAARAVARYG 121 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I VG+D + + + T + + ++ + +Q G ++ +++ Sbjct: 122 AR-IAVGVDIK----------DGFAAVKGWTEKSPLKAFEFCRRMQSDGVSTLICTDISR 170 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 DG+ G ++ K + + +IASGG +++ Sbjct: 171 DGMMQGTNVALYKTLSTELKMRIIASGGVSSLD 203 >UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase n=2 Tax=Rothia mucilaginosa RepID=D2NNQ2_9MICC Length = 262 Score = 47.4 bits (111), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 98/227 (43%), Gaps = 21/227 (9%) Query: 6 IIPCLDVRDGQVVK--GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +D+ +G V+ G E D V A + + GA + D+ + GR + Sbjct: 8 LLPAVDISEGYAVRPVGGTLSGGEQRLDPVEAALTWVKAGARWIHLVDLDLAF-GRGTNT 66 Query: 64 SWVSRVAEVI-----------DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 ++ V + + V+GG+++ E + LS D++++ S ALAD + Sbjct: 67 EVLAEVVAAVRAENARMTGSAPVRIQVSGGVRNPESLERALSLNPDRVNVTSAALADSSW 126 Query: 113 ITRLADRFG-VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + R+ + +G+D Y E G V + T D S V E L W++ R Sbjct: 127 LEGTLARYADSDLLALGLDARYTPERGWVTVARGT-DWSGPGVA--EALAWLEGAGVR-- 181 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 ++ +++DG G E L V P++ASGG ++ ++ Sbjct: 182 -RYIVTDVSKDGSLAGPGAELLDVVLAQTDRPVVASGGVASLADLVK 227 >UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NHA2_KYTSD Length = 470 Score = 47.0 bits (110), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 82/211 (38%), Gaps = 22/211 (10%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 R+ P +DVR G+ Q + D + +GA+ L D+ ++ G + + Sbjct: 4 RLWPAVDVRGGRTA---QVDPDSPLSDPQAAVDHWVAQGAERLHLVDLDRAT-GAGENDA 59 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 + R+ +P V+GGI S D + LS+GA ++ +S ADP G + Sbjct: 60 LLERLVRRASVPVEVSGGILSPRDVERALSWGAVAVTTSSALWADPAAALEWLQGCGAE- 118 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQW---ETLDWVQEVQKRGAGEIVLNMMNQ 181 + VGID GD R T D ++ G VL Sbjct: 119 VQVGID--------------LVGDRVVARGTDLALGPVADLWPDLAGLGERRWVLASAAA 164 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGT 212 DG G DL L+ E LIASGG T Sbjct: 165 DGRMTGPDLAGLRAATEHLTGTLIASGGVST 195 >UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M908_CALMQ Length = 228 Score = 46.6 bits (109), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 30/135 (22%), Positives = 71/135 (52%), Gaps = 11/135 (8%) Query: 2 LAKRIIPCLDVRDGQVVKGVQ-FRNHEII----GDIVPLAKRYAEEGADELVFYDITASS 56 +++ +IP +D+ +G VVK V+ + E++ + + L K Y + D+ + Sbjct: 1 MSRLVIPSIDLSNGLVVKRVRGVKGSELVKLNLNEALSLVKDYPF-----IHVVDLNGAE 55 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 G+ ++ ++++ ++ V GG++ +EDA +L + ++ + + A+ +P L+ + Sbjct: 56 LGKPINVDSIAKIGATVNGRCEVGGGVRVIEDAELLLKY-CSRVVLGTVAVENPALLLNM 114 Query: 117 ADRFGVQCIVVGIDT 131 +R GV + V +DT Sbjct: 115 INRLGVDKVAVSLDT 129 >UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N0X3_9GAMM Length = 240 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 55/246 (22%), Positives = 107/246 (43%), Gaps = 16/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI-IGDIVPL--AKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ Q + +I I D P+ A +A+ GA L D+ + G + Sbjct: 3 LIPAIDIQAGRCVRLKQGQFEQITIFDTPPVERAAYFAKIGAQRLHVVDLDGAQIGSMQQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + I GGI+SLE A S G + + S A+++ L T++ Sbjct: 63 LPLICSMQNT-GINVQAGGGIRSLEQAKLCFSAGIANLVLGSIAISNRELATQIIQEISP 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++ +D + G ++ + W+ + + Q++ G +I+ + D Sbjct: 122 KNIILALDIRL---INGIPIPATHGWQTMSNRNLWDVVSYYQQL---GIQQILCTDIACD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLI---ASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 G+ G + ++ V P+I ASGG E +EA V A+ ++ + Sbjct: 176 GMMQGPNFSLYQEA--VKRFPMIDWQASGGIRNQED-IEALDKLGVAAAILGLSLYQGTL 232 Query: 240 NIGELK 245 ++ E K Sbjct: 233 HLAEYK 238 >UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Leptospira biflexa serovar Patoc RepID=HIS4_LEPBA Length = 247 Score = 46.2 bits (108), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/243 (19%), Positives = 108/243 (44%), Gaps = 28/243 (11%) Query: 6 IIPCLDVRDGQVVKGVQF-RNHEIIGDIVP--LAKRYAEEGADELVFYDITASSDGRVVD 62 ++P +D+ D + V+ +Q + + + P + + + E+GA + D+ A+ G+ + Sbjct: 3 VLPAIDLLDNEAVRLLQGDYSKKTVYSSSPEKMIQVFEEQGATLIHIVDLNAAKTGKSEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ E + + GGI+++++ G ++ + + A+ +P ++ + FG Sbjct: 63 EKTIKKIKEKCTVDLELGGGIRTIDNMKFYDGLGVSRLILGTVAVEEPNVVEKAVSLFGQ 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWET------LDWVQEVQKRGAGEIVL 176 IV+G+D N Y R WE+ D++ + G ++ Sbjct: 123 DRIVIGVDAK----------NGY------VRTKGWESNSGILYKDFLTTMYGMGIRHVIF 166 Query: 177 NMMNQDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 + +DG+ G + ++ E + L+ASGG + E +E + +G L ++ Sbjct: 167 TDIARDGMMEGPNTLAYAELLETFPDLQLVASGGVSSKEDLVELYDKT--NGKLFGAITG 224 Query: 236 KQI 238 K I Sbjct: 225 KAI 227 >UniRef50_B8FH09 Dihydrouridine synthase DuS n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FH09_DESAA Length = 328 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/86 (33%), Positives = 48/86 (55%), Gaps = 4/86 (4%) Query: 33 VPLAKRYAEEGADELVFYDITASSDGRVVDKSW--VSRVAEVIDIPFCVAGGIKSLEDAA 90 V +A+ + +EGAD L+F+ A D R W + V + + +P G + SL+DAA Sbjct: 154 VSMARLFCDEGADALIFHPRVAP-DLRTRPPKWEYIGLVKDAVKVPVFGNGNVISLDDAA 212 Query: 91 KILSF-GADKISINSPALADPTLITR 115 K+LS G D +++ ALA P ++ + Sbjct: 213 KMLSMSGCDGVALGRIALAQPWIMAQ 238 >UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 n=15 Tax=Rhodobacterales RepID=HIS41_SILST Length = 247 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 56/241 (23%), Positives = 95/241 (39%), Gaps = 15/241 (6%) Query: 6 IIPCLDVRDGQVV---KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +++ DG+ V KG D V AK +AE GA+ + D A G + Sbjct: 3 IYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQ-GDSSN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + +P + GGI+S E A + G ++ I + A DP + LA + Sbjct: 62 QDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYPD 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q +V+ +D W G+ E + W +V+ I++ ++ D Sbjct: 122 Q-VVLAVDVW----QGQVMT------EGWRKSGAWTPEAFVKAFGNAPFAGILVTDIDSD 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 L + + E H P+IASG + + ++ GAL + I + Sbjct: 171 MSDLDAQLGLISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLE 230 Query: 243 E 243 E Sbjct: 231 E 231 >UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Methanopyrus kandleri RepID=HIS4_METKA Length = 242 Score = 45.4 bits (106), Expect = 0.002, Method: Compositional matrix adjust. Identities = 54/246 (21%), Positives = 108/246 (43%), Gaps = 25/246 (10%) Query: 2 LAKRIIPCLDVRDG---QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFY------DI 52 +A +IP +DV +G Q+V+G R D V A +++E F+ D+ Sbjct: 1 MAFVVIPSVDVVEGKCVQLVEGDPERRTFESDDPVETAHQWSE-------FFPWIHVVDV 53 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 A+ G + + R+ E +D V GGI+S E A +++ GAD++ + + A D Sbjct: 54 DAAR-GEGDNSDIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDD 112 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 +++ D C GI+ + + + H +G + VT + ++ EV A Sbjct: 113 FSKIVD----VCHDHGIEVFVALDVNENHEVLVSGWKEDAGVTLEDAIERFNEV----AD 164 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 + ++ +G G D + ++K +P++ +GG +++ A + + Sbjct: 165 GYLTTAVHVEGKEMGIDEKVVEKSTGATDLPVLYAGGIASIKDVKRAKEAGAYGVVIGTA 224 Query: 233 VFHKQI 238 ++H I Sbjct: 225 LYHGDI 230 >UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVE8_9SPHI Length = 244 Score = 45.1 bits (105), Expect = 0.002, Method: Compositional matrix adjust. Identities = 50/250 (20%), Positives = 111/250 (44%), Gaps = 13/250 (5%) Query: 6 IIPCLDVRDGQVV--KGVQFRNHEII-GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP + + +G+ V K F E I + + +A+ + G L D+ + G + Sbjct: 4 VIPSIWLINGKCVRLKRGDFATEEAISNNPLEIAQGFESIGIKRLHLVDLDGARRGEPKN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A ++ GG+ + D K FGA ++I+S A P ++ +G Sbjct: 64 YHILEAIAGYTNLHVDFTGGVTTDGDVIKSFEFGAKTVTISSAAANYPERFSQFILSYGR 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I + DT + K + + + T+ + D ++ RG + + + +D Sbjct: 124 EKINLAADT--NPADRKIKIRGW------LKKTEIDLYDHIEFFYDRGLKYLKCSDVTRD 175 Query: 183 GVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 GV G + E V++ ++ + ASGG ++E F E + V+ A+ +++ ++ + Sbjct: 176 GVMVGPNFELYADLVKKFPNLNIAASGGVRSIEDFKE-LKKLGVNAAVFGRAYYEGMLKL 234 Query: 242 GELKAYLATQ 251 +L +++ + Sbjct: 235 EDLADFISEK 244 >UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Coriobacteriaceae RepID=C8WPG6_EGGLE Length = 257 Score = 44.3 bits (103), Expect = 0.004, Method: Compositional matrix adjust. Identities = 51/242 (21%), Positives = 107/242 (44%), Gaps = 15/242 (6%) Query: 6 IIPCLDVRDGQVV---KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++P +D+ G+ V KG R D A+ + E+GA L D+ + G + Sbjct: 3 LLPAIDILGGKAVRLAKGDYDRVTVYHDDPAAQAQLFEEQGATWLHVVDLDGARSGIPEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V R+ + V GG++SL+ A++ G ++ + + +ADP ++G Sbjct: 63 IAIVERIMRKTLLKVEVGGGVRSLDTIARLADAGVSRVVLGTSLVADPDFAEAAIAQYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + GI DA+ G+ V + E + + +++ G +V + +D Sbjct: 122 KLLCAGI----DAKGGEVAVAGWR--EGAGVAAE----ELARDMSALGFRHLVYTDIARD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA-DVDGALAASVFHKQIINI 241 G++ G + ++ E P+IASGG ++ + A ++G +A ++ +++ Sbjct: 172 GMQTGIEAAAYVRMAEAFGHPVIASGGVAGVDDIVRLGEVAGSIEGVIAGRAVYEGALSV 231 Query: 242 GE 243 E Sbjct: 232 QE 233 >UniRef50_Q1ZGI3 NifR3/Smm1 family protein n=1 Tax=Psychromonas sp. CNPT3 RepID=Q1ZGI3_9GAMM Length = 313 Score = 43.9 bits (102), Expect = 0.005, Method: Compositional matrix adjust. Identities = 39/142 (27%), Positives = 59/142 (41%), Gaps = 20/142 (14%) Query: 36 AKRYAEEGADELVFYDITASSD-GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILS 94 A+ E GA+EL + T W++++ E IDIP G I S EDA + Sbjct: 154 AQAICEAGANELAVHARTKEEGYAPPAHWHWIAKIRESIDIPVTANGDIFSAEDAKRCHE 213 Query: 95 F-GADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYD-----AETGKYHVNQYTGD 148 G + I ALA P L ++ GI+ Y +Y + Q GD Sbjct: 214 ISGCHSLMIGRGALATPNLAQ----------VIKGIEEPYSWPQILTLMSQYLIVQTHGD 263 Query: 149 ESR---TRVTQWETLDWVQEVQ 167 + + +R+ QW T +Q+ Q Sbjct: 264 KEKYLPSRIKQWLTFMRLQQPQ 285 >UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermoproteaceae RepID=HIS4_PYRAE Length = 229 Score = 43.1 bits (100), Expect = 0.010, Method: Compositional matrix adjust. Identities = 29/92 (31%), Positives = 52/92 (56%), Gaps = 4/92 (4%) Query: 6 IIPCLDVRDGQVVKGV--QFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP +D+ G+ VK + Q N+ GD + LA R+ + +V D+ + G +V+ Sbjct: 2 IIPSIDIEGGRAVKRIRGQRGNYIFQGDPLELAARFRKAPLVHVV--DLDGAEAGGLVNI 59 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSF 95 S +S++AE+++ + GG++SLE + LS Sbjct: 60 SVISKIAEILEGRCELGGGLRSLEAVERALSL 91 >UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_MYXXD Length = 238 Score = 42.4 bits (98), Expect = 0.017, Method: Compositional matrix adjust. Identities = 45/211 (21%), Positives = 89/211 (42%), Gaps = 14/211 (6%) Query: 7 IPCLDVRDG---QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IP +D+R+G Q+V G + + + K++ G D+ A+ Sbjct: 4 IPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSNAD 63 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + A + F V GG++ + +LS GA+ + + + A+ D + +A+RF + Sbjct: 64 AIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPGR 123 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 +V + T + + + R + +E L G +++ ++++G Sbjct: 124 VVVAADVKGREVVTRGWTAGSHR--DIREVLAAFEPLPL---------GGLLVTAVHKEG 172 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTME 214 +G DL +++V L ASGG TME Sbjct: 173 QLSGVDLPLMREVASTSRHRLYASGGVTTME 203 >UniRef50_B2V631 Thiamine-phosphate pyrophosphorylase n=3 Tax=Sulfurihydrogenibium RepID=B2V631_SULSY Length = 206 Score = 41.2 bits (95), Expect = 0.033, Method: Compositional matrix adjust. Identities = 24/70 (34%), Positives = 38/70 (54%), Gaps = 5/70 (7%) Query: 35 LAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILS 94 L+ YA G+ FY +VVDKS ++ + IP CV GGI ++E A +++ Sbjct: 119 LSATYAAFGS----FYPSPTKPKSKVVDKSAITEAKRFLKIPVCVIGGI-TVERAKELVE 173 Query: 95 FGADKISINS 104 GAD +++ S Sbjct: 174 LGADLVAVIS 183 >UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Opitutaceae RepID=HIS4_OPITP Length = 243 Score = 40.8 bits (94), Expect = 0.040, Method: Compositional matrix adjust. Identities = 51/240 (21%), Positives = 101/240 (42%), Gaps = 21/240 (8%) Query: 6 IIPCLDVRDGQVVKGVQFR-NHEIIGDIVP--LAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++ G+ V+ Q R E I P +A ++ G++ + D+ + G + Sbjct: 3 IYPAIDIKGGRCVRLTQGRAEQETIYAQNPADVAMQFRAAGSEWVHVVDLDGAFAGEPQN 62 Query: 63 KSWVSRVAEV-IDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V + V + + F GG+++ + L+ G ++ + + A + + L FG Sbjct: 63 LAAVQAIVAVGMKVQF--GGGLRTRAAVERALALGVSRVVLGTRAAESESFVGELVQAFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I VGI DA+ GK V + TL + + G ++ + Sbjct: 121 DK-IAVGI----DAKNGKVAVKGWVA------TADLSTLVLARRMDTLGVATLIHTDIGT 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE----AFRDADVDGALAASVFHKQ 237 DG+ G +L + + +IASGG + + A R A++DG + +++ Sbjct: 170 DGMLTGPNLAAQEALCSAVKSRVIASGGVSRRDDVVNLAKLAQRHANLDGVIVGKALYER 229 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 40.8 bits (94), Expect = 0.043, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 29/51 (56%) Query: 70 AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 A+ + IP C GG+++ EDAA+ + GA +S+ S L DP R+ + Sbjct: 237 AQAVSIPICGVGGVETGEDAAEFILAGATAVSVGSANLYDPMCAPRILNEL 287 >UniRef50_Q036K5 Dioxygenase n=19 Tax=Bacteria RepID=Q036K5_LACC3 Length = 328 Score = 40.4 bits (93), Expect = 0.065, Method: Compositional matrix adjust. Identities = 25/78 (32%), Positives = 40/78 (51%), Gaps = 4/78 (5%) Query: 24 RNHEIIGDIVP---LAKRYAEEGADELVFYDITASSD-GRVVDKSWVSRVAEVIDIPFCV 79 +N I+ +VP +AKR A++G D ++ + + G + + V +V + +DIP Sbjct: 107 QNGTIVMPVVPSVAMAKRMAKDGVDGVIAEGMESGGHIGSITTMALVPQVVDAVDIPVVA 166 Query: 80 AGGIKSLEDAAKILSFGA 97 AGGI A LS GA Sbjct: 167 AGGIADGRGVAAALSLGA 184 >UniRef50_Q2RIV8 5-methyltetrahydrofolate--homocysteine S-methyltransferase n=2 Tax=Moorella thermoacetica ATCC 39073 RepID=Q2RIV8_MOOTA Length = 265 Score = 40.0 bits (92), Expect = 0.079, Method: Compositional matrix adjust. Identities = 29/97 (29%), Positives = 47/97 (48%), Gaps = 5/97 (5%) Query: 35 LAKRYAEEGADELVFYDITASSDGRVVDKSW-VSRVAEVIDIPFCV-AGGIKSLEDAAKI 92 LA+R AE GAD + D+ + V D W V V EV D+P C+ + ++++ + Sbjct: 30 LARRQAEAGAD---YLDLNTAHCDEVADMEWLVHTVQEVTDVPLCIDSTAGEAIKKGLET 86 Query: 93 LSFGADKISINSPALADPTLITRLADRFGVQCIVVGI 129 + K+ INS ++ L L QC V+G+ Sbjct: 87 VKGDKSKVIINSISMEKKRLEEVLPLVLEYQCPVIGL 123 >UniRef50_A2EN54 Putative uncharacterized protein n=1 Tax=Trichomonas vaginalis RepID=A2EN54_TRIVA Length = 321 Score = 40.0 bits (92), Expect = 0.085, Method: Compositional matrix adjust. Identities = 37/112 (33%), Positives = 50/112 (44%), Gaps = 7/112 (6%) Query: 33 VPLAKRYAEEGADELVFYDITASSDGR-VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAK 91 V AK E GA + + +A+ D ++K V V + + IP V GGI SL+DA Sbjct: 161 VDFAKHLEEAGASLITIHGRSAAQDKHGPLNKELVKAVVQAVSIPVIVNGGINSLDDARN 220 Query: 92 IL-SFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHV 142 ++ GA L DPTL D+ G Q V + D KYHV Sbjct: 221 MIRETGAIAAMSAQSLLMDPTLF----DKNGRQPNTVFALEYLDI-FEKYHV 267 >UniRef50_A2ST44 Histidine biosynthesis protein n=1 Tax=Methanocorpusculum labreanum Z RepID=A2ST44_METLZ Length = 221 Score = 39.7 bits (91), Expect = 0.092, Method: Compositional matrix adjust. Identities = 23/84 (27%), Positives = 42/84 (50%), Gaps = 1/84 (1%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL 217 + ++ ++E K I+L ++ G +G DL+ K++R PL+ GG T++ L Sbjct: 130 DPVEVIREADKYAFDGIILLNISSVGTESGIDLDFAKRIRAATKKPLLYGGGVNTLDD-L 188 Query: 218 EAFRDADVDGALAASVFHKQIINI 241 DA DG + ++ HK I + Sbjct: 189 RTLCDAGYDGVIISTSVHKGKIPV 212 >UniRef50_C8VZK1 NADH:flavin oxidoreductase/NADH oxidase n=1 Tax=Desulfotomaculum acetoxidans DSM 771 RepID=C8VZK1_DESAS Length = 647 Score = 39.7 bits (91), Expect = 0.097, Method: Compositional matrix adjust. Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 5/92 (5%) Query: 69 VAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA-DRFGVQ-CIV 126 +AE +DIP C G I S++ A K+L+ G + +ADP L R D ++ CI+ Sbjct: 284 IAEAVDIPVCATGSIVSVKLAEKLLNEGVQLAEMTRALIADPDLPARAKEDETNIRPCIL 343 Query: 127 VGIDTWYDAETGKY---HVNQYTGDESRTRVT 155 D + ++ VN + G+E + T Sbjct: 344 CNQDCYVNSVMNPVLSCAVNPFAGEELKETYT 375 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hi... 313 4e-84 UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hi... 309 7e-83 UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hi... 304 2e-81 UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hi... 301 2e-80 UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hi... 298 1e-79 UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hi... 297 2e-79 UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hi... 297 3e-79 UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hi... 293 3e-78 UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hi... 293 4e-78 UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hi... 286 4e-76 UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hi... 286 5e-76 UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillon... 283 3e-75 UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hi... 281 1e-74 UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hi... 279 8e-74 UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hi... 277 2e-73 UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hi... 277 2e-73 UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hi... 275 1e-72 UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hi... 275 1e-72 UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hi... 274 2e-72 UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hi... 271 1e-71 UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hah... 271 1e-71 UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hi... 270 5e-71 UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hi... 266 4e-70 UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococ... 266 5e-70 UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hi... 263 5e-69 UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 261 1e-68 UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfati... 258 9e-68 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase s... 257 2e-67 UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, c... 257 3e-67 UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winog... 256 5e-67 UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 255 1e-66 UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Pro... 255 2e-66 UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hi... 254 2e-66 UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hi... 254 3e-66 UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picr... 253 4e-66 UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 253 4e-66 UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase su... 252 9e-66 UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanae... 251 1e-65 UniRef50_P72139 Putative imidazole glycerol phosphate synthase s... 251 1e-65 UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 251 1e-65 UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase s... 251 1e-65 UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase su... 251 2e-65 UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 250 4e-65 UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter... 250 5e-65 UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 248 1e-64 UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase s... 248 1e-64 UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 247 2e-64 UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hi... 247 3e-64 UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 245 1e-63 UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovi... 244 2e-63 UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 244 2e-63 UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 244 2e-63 UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Pro... 244 2e-63 UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase su... 244 3e-63 UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 243 6e-63 UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 8e-63 UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 8e-63 UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 9e-63 UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 241 1e-62 UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 241 2e-62 UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 241 2e-62 UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase s... 240 3e-62 UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 3e-62 UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxa... 240 3e-62 UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 4e-62 UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria ... 239 6e-62 UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 6e-62 UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 2e-61 UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 2e-61 UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 2e-61 UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 237 3e-61 UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxa... 237 3e-61 UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobact... 236 6e-61 UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 8e-61 UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 8e-61 UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 235 1e-60 UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 235 1e-60 UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 3e-60 UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 7e-60 UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 232 9e-60 UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase s... 232 1e-59 UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 231 2e-59 UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine... 231 2e-59 UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 231 2e-59 UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 4e-59 UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase su... 230 4e-59 UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 4e-59 UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 229 5e-59 UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 229 5e-59 UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 229 5e-59 UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_Y... 229 8e-59 UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 229 9e-59 UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 228 1e-58 UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 228 1e-58 UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Pr... 228 1e-58 UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C... 228 2e-58 UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 227 3e-58 UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 227 3e-58 UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=... 226 5e-58 UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 6e-58 UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 7e-58 UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole ... 224 2e-57 UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 2e-57 UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 3e-57 UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 4e-57 UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hi... 223 5e-57 UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 5e-57 UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 7e-57 UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 9e-57 UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomyc... 222 9e-57 UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 1e-56 UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 1e-56 UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 1e-56 UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase s... 221 2e-56 UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 3e-56 UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 3e-56 UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 4e-56 UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 4e-56 UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 219 5e-56 UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 219 7e-56 UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 1e-55 UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis... 218 1e-55 UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 1e-55 UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 1e-55 UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 2e-55 UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 2e-55 UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole... 218 2e-55 UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 4e-55 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 6e-55 UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes:... 216 6e-55 UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 8e-55 UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii H... 215 9e-55 UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovi... 215 1e-54 UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 215 1e-54 UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 2e-54 UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 3e-54 UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 4e-54 UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 5e-54 UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 9e-54 UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 9e-54 UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter... 212 9e-54 UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 1e-53 UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 1e-53 UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 210 3e-53 UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 209 5e-53 UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 209 9e-53 UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 1e-52 UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 2e-52 UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 2e-52 UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacte... 207 2e-52 UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 207 3e-52 UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit Hi... 207 3e-52 UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 6e-52 UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 6e-52 UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 6e-52 UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 6e-52 UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxa... 205 1e-51 UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 205 1e-51 UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 205 1e-51 UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 2e-51 UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hi... 204 2e-51 UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase su... 204 2e-51 UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms Re... 204 2e-51 UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n... 204 3e-51 UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 204 3e-51 UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 203 7e-51 UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 203 7e-51 UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. ... 202 8e-51 UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxa... 202 9e-51 UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogen... 202 1e-50 UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 200 3e-50 UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 200 4e-50 UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 200 4e-50 UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase su... 200 5e-50 UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 199 1e-49 UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 198 2e-49 UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID... 197 2e-49 UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazol... 196 5e-49 UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase Hi... 194 3e-48 UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malasse... 191 1e-47 UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 189 7e-47 UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=La... 188 2e-46 UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collins... 187 2e-46 UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 187 3e-46 UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase s... 184 2e-45 UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 184 3e-45 UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 183 4e-45 UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 182 8e-45 UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 182 1e-44 UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlo... 181 2e-44 UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit H... 181 2e-44 UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3... 178 2e-43 UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxa... 177 2e-43 UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 174 3e-42 UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlo... 173 6e-42 UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlo... 172 1e-41 UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 167 3e-40 UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 161 2e-38 UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxa... 159 9e-38 UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 T... 141 2e-32 UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirg... 140 3e-32 UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanoco... 140 6e-32 UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxa... 136 6e-31 UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanoco... 136 7e-31 UniRef50_Q1NTJ9 Histidine biosynthesis n=1 Tax=delta proteobacte... 133 5e-30 UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlo... 131 2e-29 UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi... 105 1e-21 UniRef50_Q9F8I8 Cyclase (Fragment) n=1 Tax=Carboxydothermus hydr... 84 5e-15 Sequences not found previously or not previously below threshold: UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 219 1e-55 UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 210 5e-53 UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 4e-52 UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 194 3e-48 UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxa... 186 8e-46 UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spir... 182 1e-44 UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanae... 178 1e-43 UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 164 2e-39 UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 164 2e-39 UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 153 7e-36 UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosyl... 150 4e-35 UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxa... 145 1e-33 UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicr... 138 2e-31 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 137 5e-31 UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 134 4e-30 UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 132 8e-30 UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 132 1e-29 UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 130 5e-29 UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 130 5e-29 UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 125 2e-27 UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepI... 105 1e-21 UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanoco... 100 4e-20 UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococ... 100 9e-20 UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Me... 99 1e-19 UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methano... 99 2e-19 UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales... 96 1e-18 UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxa... 95 2e-18 UniRef50_D2MIW0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 86 9e-16 UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oce... 85 3e-15 UniRef50_Q10184 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 84 5e-15 UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole ... 82 1e-14 UniRef50_O82782 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 81 3e-14 UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methano... 79 1e-13 UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobial... 79 2e-13 UniRef50_C4ZG69 APG10 (Albino and pale green 10); 1-(5-phosphori... 79 2e-13 UniRef50_B2UL06 Phosphoribosylformimino-5-aminoimidazole carboxa... 77 5e-13 UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planc... 75 3e-12 UniRef50_D1JF95 Putative phosphoribosylformimino-5-aminoimidazol... 74 5e-12 UniRef50_Q2FS89 Histidine biosynthesis n=1 Tax=Methanospirillum ... 72 1e-11 UniRef50_B7GE60 Predicted protein n=11 Tax=cellular organisms Re... 72 2e-11 >UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hisF n=157 Tax=root RepID=HIS6_HELMI Length = 261 Score = 313 bits (803), Expect = 4e-84, Method: Composition-based stats. Identities = 121/257 (47%), Positives = 160/257 (62%), Gaps = 1/257 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV G+VVKG F N GD V LA Y +EGADE+VF DITASSDGR Sbjct: 1 MLAKRIIPCLDVHGGRVVKGTNFVNLRDAGDPVELAAVYDKEGADEVVFLDITASSDGRA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R AE + IPF V GG++S+ED ++L GADKIS+N+ A+ P LI+ A +F Sbjct: 61 IMLDVVRRTAEEVFIPFTVGGGLRSVEDIREMLKAGADKISLNTSAVQTPKLISDGAWKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G QCIVV ID + V + + T + L+W + V++ GAGEI+L M Sbjct: 121 GSQCIVVAIDARRRRDAEGNPVEGWEVYTHGGRKPTGIDVLEWARRVEELGAGEILLTSM 180 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG ++GYD+ + V E +P+IASGG G ++H +E D ALAAS+FH + Sbjct: 181 DKDGTKDGYDIPLTRAVSEAVTIPVIASGGVGNLDHIVEGLTVGKADAALAASIFHYREY 240 Query: 240 NIGELKAYLATQGVEIR 256 IGE K YL +GV +R Sbjct: 241 TIGETKEYLRERGVHVR 257 >UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hisF n=10 Tax=Bacteria RepID=HIS6_SULSY Length = 252 Score = 309 bits (792), Expect = 7e-83, Method: Composition-based stats. Identities = 124/257 (48%), Positives = 164/257 (63%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV G+VVKGV F N GD V +A Y +EGADELVF DITASS+ R Sbjct: 1 MLAKRIIPCLDVDKGRVVKGVNFVNLIDAGDPVEIASVYDKEGADELVFLDITASSEDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V + AE + +P V GG++SLED K+L GADK+SIN+ A+ +P+L+ A RF Sbjct: 61 IILDVVKKTAETVFMPLTVGGGVRSLEDIRKLLENGADKVSINTAAVKNPSLVENAAIRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVV ID E K+ V + G T + ++W + V+ GAGEI+L M+ Sbjct: 121 GSSTIVVAIDAKKVGEN-KWEVYIHGGR----TPTGIDAIEWAKAVESLGAGEILLTSMD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG ++GYD+E K V E +P+IASGGAG ++HF EAF D LAAS+FH + I Sbjct: 176 KDGTKSGYDIELTKAVSEAVKIPVIASGGAGNVQHFYEAFEYGKADACLAASLFHFKEIE 235 Query: 241 IGELKAYLATQGVEIRI 257 I ELK YL +G+ +R+ Sbjct: 236 ISELKNYLKNKGINVRL 252 >UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=C7P985_METFA Length = 272 Score = 304 bits (779), Expect = 2e-81, Method: Composition-based stats. Identities = 117/271 (43%), Positives = 163/271 (60%), Gaps = 14/271 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIPCLD++DG+VVKG +F N GD V LA+ Y +EGADELVF DITAS++ R Sbjct: 1 MLTKRIIPCLDIKDGRVVKGTKFLNLRDAGDPVELAQLYDDEGADELVFLDITASAEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R AE + IP V GGIKS+ED KIL GADKISIN+ A+ +P LI ++ F Sbjct: 61 IIIDVVERTAEKVFIPLTVGGGIKSIEDFRKILRAGADKISINTAAVKNPNLIKEASEIF 120 Query: 121 GVQCIVVGIDTWY---------DAETGKYHV-NQYTGDE----SRTRVTQWETLDWVQEV 166 G QC+VV ID + V + Y E + T + ++W ++V Sbjct: 121 GSQCVVVAIDAKRHYINEDEIDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKV 180 Query: 167 QKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD 226 ++ GAGEI+L +++DG ++GYDL +++ + +P+IASGG G EH EAF D Sbjct: 181 EELGAGEILLTSIDKDGTKSGYDLILTREISKSVKLPVIASGGCGKPEHVYEAFVHGKAD 240 Query: 227 GALAASVFHKQIINIGELKAYLATQGVEIRI 257 AL A + H + I E+K Y A +G+ +R+ Sbjct: 241 AALMAGILHYKEYTIEEIKKYCADRGIPMRL 271 >UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW6_9FIRM Length = 252 Score = 301 bits (771), Expect = 2e-80, Method: Composition-based stats. Identities = 115/257 (44%), Positives = 157/257 (61%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M KRIIPCLDV+DG+VVKG F GD V LA RY EE ADELVF DITASSD R Sbjct: 1 MYTKRIIPCLDVKDGRVVKGTNFVGLRDAGDPVELAARYDEERADELVFLDITASSDNRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + A + IPF V GGI+++ED ++L GADK S+N+ A+ +P L+ A++F Sbjct: 61 TMVNVARDCASKVFIPFTVGGGIRTVEDMRRMLKAGADKTSLNTAAVKNPGLLKEGAEKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ +D A ++ V G T + L+WV++ GAGEI+L M+ Sbjct: 121 GRQCMVLAVDARR-AGNHRWEVYVNGGR----TPTGLDCLEWVKKAVALGAGEILLTSMD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG ++GYD+E + V + +VP+IASGGAG +EHF + D LAASVFH Sbjct: 176 ADGTKDGYDIELTRAVSDAVNVPVIASGGAGKLEHFYDVLTLGHADAVLAASVFHYGQFT 235 Query: 241 IGELKAYLATQGVEIRI 257 + ++K YL ++GVE+R Sbjct: 236 VRQVKEYLQSRGVEVRF 252 >UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hisF n=28 Tax=Bacteria RepID=HIS6_EXISA Length = 255 Score = 298 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 121/258 (46%), Positives = 166/258 (64%), Gaps = 8/258 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML +RIIPCLDV++G+VVKG++F IGD V +AK Y E GADELVF DITAS++ R Sbjct: 1 MLKRRIIPCLDVKEGRVVKGIEFVQLRDIGDPVEIAKYYDESGADELVFLDITASTERRQ 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VS VA + IP V GGI+SLED + +L GADK+S+N+ A+ P+LI ADRF Sbjct: 61 TMLDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID + + G+Y+V Y G + T ++W ++V GAGE+++ MN Sbjct: 121 GSQCIVVAIDVKF--KDGEYYVYTYGGKQK----TDLLAVEWAKQVAALGAGELLVTSMN 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 QDG ++GYDL L+++REV +P+IASGGAG EH +EA VD AL AS+ H + Sbjct: 175 QDGKQSGYDLSILEQLREVVDIPIIASGGAGNAEHVVEALEK--VDAALLASILHDRKTT 232 Query: 241 IGELKAYLATQGVEIRIC 258 + E+K + + +R Sbjct: 233 VEEVKHVCKSHNLPMRFV 250 >UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hisF n=27 Tax=cellular organisms RepID=HIS6_META3 Length = 275 Score = 297 bits (762), Expect = 2e-79, Method: Composition-based stats. Identities = 106/275 (38%), Positives = 157/275 (57%), Gaps = 18/275 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIPCLD+++G+VVKG F GD V L+K Y E+GADELVF DI AS + R Sbjct: 1 MLTKRIIPCLDIKNGRVVKGTNFVELRDAGDPVELSKIYNEQGADELVFLDIGASHEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V + A+ + IP V GGI++ +D +IL GADKIS+N+ A+ +P LI + ++ + Sbjct: 61 IIEHLVEKTADQVFIPLTVGGGIRTTDDFRRILRAGADKISVNTAAIHNPDLIKQSSELY 120 Query: 121 GVQCIVVGIDTWY--------------DAETGKYHVNQYTGDE----SRTRVTQWETLDW 162 G QC+VV ID+ D K N+Y E + T + ++W Sbjct: 121 GAQCVVVAIDSKRHYVNEEDLDSKQLEDKNVVKVDKNKYCWFEVFIYGGRKETGIDAIEW 180 Query: 163 VQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRD 222 + ++ GAGEI+L M+ DG ++GYD+E K + +P+IASGG G +H + F Sbjct: 181 AKTAEELGAGEILLTSMDADGTKDGYDIELTKSISTHIKLPVIASGGCGAPQHIHQVFEY 240 Query: 223 ADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D AL AS+ H + +GELK Y + + +R+ Sbjct: 241 GKADAALMASILHYREYTVGELKKYCMDKNIPMRL 275 >UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hisF n=354 Tax=cellular organisms RepID=HIS6_METBU Length = 273 Score = 297 bits (761), Expect = 3e-79, Method: Composition-based stats. Identities = 112/274 (40%), Positives = 154/274 (56%), Gaps = 18/274 (6%) Query: 1 MLAKRIIPCLDV----RDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 ML KRIIPCLDV G VVKGV+F + + GD V LAKRY E+GADELVF DITAS Sbjct: 1 MLTKRIIPCLDVTLDASGGTVVKGVEFVDLKKAGDPVDLAKRYNEQGADELVFLDITASH 60 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 +GR + R A + IP V GGI S+ED +IL GADK+S+N+ A+ +P I Sbjct: 61 EGRSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREA 120 Query: 117 ADRFGVQCIVVGIDTWYD-------------AETGKYHVNQYTGDESRTRVTQWETLDWV 163 ++ FG QCIV ID + E G + T +T+ W Sbjct: 121 SNIFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIY-GGREPTGLDTVQWA 179 Query: 164 QEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA 223 ++V++ G+GEI+L MN+DG +G+D+ KK+ E +P+IASGG G EH + F D Sbjct: 180 KKVEELGSGEILLTSMNRDGTYDGFDIPITKKLSEELDIPIIASGGVGNPEHMYKGFVDG 239 Query: 224 DVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D LAAS+FH + ++K L + + +R+ Sbjct: 240 KADAGLAASIFHFGEYTVRDVKEALRAKNIPVRL 273 >UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=HIS6_THEYD Length = 278 Score = 293 bits (752), Expect = 3e-78, Method: Composition-based stats. Identities = 121/278 (43%), Positives = 165/278 (59%), Gaps = 21/278 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV+DG+VVKGV F N GD V A Y EE ADELVF D+TAS + R Sbjct: 1 MLAKRIIPCLDVKDGRVVKGVNFLNLRDAGDPVENALYYNEEEADELVFLDVTASHEKRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R A V+ +P V GGIKSL+D +L+ GADK+SIN+ A+ DP I + + RF Sbjct: 61 IIIDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRF 120 Query: 121 GVQCIVVGIDTWYDAETGK---YHVNQYTGDESRTRVT------------------QWET 159 G QCIV+ ID + Y + D+ + V + Sbjct: 121 GSQCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRPIDA 180 Query: 160 LDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA 219 + W +++++ GAGEI+L M++DG + GYD+E + + E +P+IASGGAGT+EH EA Sbjct: 181 IAWAKKMEEFGAGEILLTSMDRDGTKEGYDIELTRAISEAVSIPVIASGGAGTLEHLYEA 240 Query: 220 FRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 F A D ALAAS+FH + +I E K +L +G+ +RI Sbjct: 241 FAYAKADAALAASIFHFREYSIREAKEFLRQKGIPVRI 278 >UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hisF n=224 Tax=Bacteria RepID=HIS6_STACT Length = 254 Score = 293 bits (751), Expect = 4e-78, Method: Composition-based stats. Identities = 107/256 (41%), Positives = 161/256 (62%), Gaps = 4/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ KRIIPCLDV+DG+VVKGVQF+ IGD V LA Y E ADELVF DI+ + +G Sbjct: 1 MIKKRIIPCLDVKDGRVVKGVQFKGLRDIGDPVALAAYYNAELADELVFLDISRTENGHQ 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + A + IP + GGI S +D + +L GADK+S+NS AL +P+L+ +++F Sbjct: 61 MMLDIIEETASKLFIPLTIGGGISSTDDISTLLKHGADKVSLNSSALRNPSLVKEASEKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI + +D ++ E + + G + T LDWV++V+ GAGE+++ M+ Sbjct: 121 GSQCICIAVDAKWEDERNDWFCYTHGGKQ----PTDIRVLDWVRQVEYLGAGELLVTSMD 176 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV+ G+D + L ++ V +P+IASGG G +HF++ F+ +V LAAS+FH + Sbjct: 177 YDGVKQGFDHQLLNQINTVVSIPVIASGGGGNAQHFVDLFQQTNVSAGLAASIFHDKETT 236 Query: 241 IGELKAYLATQGVEIR 256 IG +K YL +GV++R Sbjct: 237 IGAVKTYLKDKGVDVR 252 >UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hisF n=420 Tax=cellular organisms RepID=HIS6_BRUMB Length = 261 Score = 286 bits (734), Expect = 4e-76, Method: Composition-based stats. Identities = 109/259 (42%), Positives = 153/259 (59%), Gaps = 7/259 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L R+IPCLDV+DG+VVKGV F + GD V A+ Y GADEL F DITASSD R Sbjct: 3 LKARVIPCLDVKDGRVVKGVNFVDLIDAGDPVEAARAYDAAGADELCFLDITASSDNRET 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+R AE +P V GG++ + D K+L GADK+SIN+ A+ +P + AD+FG Sbjct: 63 IFDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFG 122 Query: 122 VQCIVVGIDTWYDAETGK---YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 QCIVV ID + G+ + + + G + T + +++ Q+V GAGEI+L Sbjct: 123 NQCIVVAIDAKKVSGAGENDHWEIFTHGGRQ----PTGIDAVEFAQKVVDLGAGEILLTS 178 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 M++DG + GYD+ + V + P+IASGG GT++H + RD LAAS+FH Sbjct: 179 MDRDGTKAGYDVALTRAVADSVRAPVIASGGVGTLDHLVAGIRDGHATAVLAASIFHFGT 238 Query: 239 INIGELKAYLATQGVEIRI 257 IGE K Y+A G+ +R+ Sbjct: 239 YTIGEAKRYMAEAGIPMRL 257 >UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hisF n=55 Tax=cellular organisms RepID=HIS6_THEEB Length = 281 Score = 286 bits (732), Expect = 5e-76, Method: Composition-based stats. Identities = 111/256 (43%), Positives = 149/256 (58%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRI+PCLDV+ G+VVKGV F N GD V LA+ Y GADELVF DITA+ + R Sbjct: 2 MLAKRILPCLDVKAGRVVKGVNFVNLRDAGDPVELAQAYNAAGADELVFLDITATHEERN 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R A+ + IP V GGI+SL +L GADK+S+NS A+ P L+ + +DRF Sbjct: 62 ILIDVVYRTADQVFIPLTVGGGIQSLTMIKDLLRAGADKVSLNSAAVRQPDLVNQASDRF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID + + T + + W E+ KRGAGE+++ M+ Sbjct: 122 GAQCIVVAIDARREPDCAPDQPRWQVYVRGGREATGLDAVAWAVEMAKRGAGELLVTSMD 181 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + GYDLE + + E +P+IASGGAGT EH A + + AL AS+ H + Sbjct: 182 ADGTQAGYDLELTRAIAERVEIPVIASGGAGTCEHIRAALVEGKAEAALLASLLHYGQLT 241 Query: 241 IGELKAYLATQGVEIR 256 I ++K YL V +R Sbjct: 242 IAQIKGYLHQHQVPVR 257 >UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC 17748 RepID=C4FS06_9FIRM Length = 256 Score = 283 bits (726), Expect = 3e-75, Method: Composition-based stats. Identities = 102/256 (39%), Positives = 158/256 (61%), Gaps = 1/256 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCL V +G+V GVQFR+ GD V A+RY +GADELV DITA+++ R Sbjct: 1 MLAKRIIPCLGVANGRVQNGVQFRDMVDAGDPVECAERYEIQGADELVLLDITATTEARK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V ++ + +P V GGI S+ED +++ GADK+SIN+ AL++P+LIT A +F Sbjct: 61 TFTDIVLNASDKVFMPLTVGGGITSVEDMTQLMKAGADKVSINTAALSNPSLITEGAKKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D Y+ ++ + G + L+W +E RGAGE+++ ++ Sbjct: 121 GNQGIVVCLDVKYNPFEKMWYAYGH-GTSNDPGAQCKNALEWAKEAVDRGAGELLVTSID 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 + G G+D+E + + EV VP+ A GGAG ++HF++ F +V GALA+++ H +++ Sbjct: 180 RHGTGLGFDIELYQALAEVVDVPVTAFGGAGNIQHFVDLFTKTNVTGALASALLHNKVLT 239 Query: 241 IGELKAYLATQGVEIR 256 I ++K L G+ +R Sbjct: 240 IKDIKKALHAAGIVVR 255 >UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hisF n=360 Tax=Bacteria RepID=HIS6_XANOM Length = 258 Score = 281 bits (721), Expect = 1e-74, Method: Composition-based stats. Identities = 163/256 (63%), Positives = 197/256 (76%), Gaps = 1/256 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML++RIIPCLDVR+G+VVKGV+F +H +GDIV LA RY +GADELVFYDI AS +GR Sbjct: 1 MLSRRIIPCLDVRNGRVVKGVKFHDHIDMGDIVELALRYRAQGADELVFYDIGASPEGRS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VD +WV RVA +IDIPFCVAGGI +E A +L GADKISINSPAL P LI+ LAD F Sbjct: 61 VDYTWVERVARLIDIPFCVAGGIGDVETARAVLHAGADKISINSPALGRPQLISELADAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 GVQC+VVGID+ + + G++ V +YTGD S+T+ TLDWV E Q+ GAGEIVLN M+ Sbjct: 121 GVQCVVVGIDSIRE-DDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMD 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGVR GYD+ QL++VR +CHVPLIASGGAG M+HF + F ADVDGALAASVFH I Sbjct: 180 NDGVRRGYDIAQLRQVRALCHVPLIASGGAGEMQHFADVFDQADVDGALAASVFHSGAIP 239 Query: 241 IGELKAYLATQGVEIR 256 I ELK +L Q +E+R Sbjct: 240 IPELKQFLRAQQIEVR 255 >UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hisF n=67 Tax=Bacteria RepID=HIS6_SYNY3 Length = 261 Score = 279 bits (714), Expect = 8e-74, Method: Composition-based stats. Identities = 118/257 (45%), Positives = 157/257 (61%), Gaps = 6/257 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LAKRI+PCLDV G+VVKG+ F + + GD V LA+ Y E GADELVF DITA+ + R Sbjct: 3 LAKRILPCLDVNAGRVVKGINFVDLQDAGDPVELARAYNEAGADELVFLDITATHEQRDT 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R AE + IP V GGI +LE +L GADK+S+NS A+ DP I+R +DRFG Sbjct: 63 IIDVVYRTAEEVFIPLTVGGGISTLEHIKNLLRAGADKVSVNSSAVRDPDFISRASDRFG 122 Query: 122 VQCIVVGIDTWY--DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 QCIVV ID DA+ + V G E+ T + + W +EV KRGAGE+++ M Sbjct: 123 RQCIVVAIDARRRLDADNPGWDVYVRGGREN----TGLDAIAWAEEVAKRGAGELLVTSM 178 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 + DG + GYDL + E +P+IASGGAG +H EAF + + AL AS+ H + Sbjct: 179 DGDGTQAGYDLALTAAIAERVEIPVIASGGAGNCQHVYEAFTEGKAEAALLASLLHYGQL 238 Query: 240 NIGELKAYLATQGVEIR 256 IGELK +L + + +R Sbjct: 239 TIGELKTFLEARQIPVR 255 >UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hisF n=19 Tax=cellular organisms RepID=HIS6_DESAA Length = 260 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 111/256 (43%), Positives = 157/256 (61%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML+KR+I CLDVRDG+ KG++F+ + IGD V +A+ Y E G DELVFYDITAS + R Sbjct: 1 MLSKRVIVCLDVRDGKTTKGIKFKGNVDIGDPVDMARVYYEAGCDELVFYDITASHEKRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V RVAE I IPF V GGI S+ED +L GA+KIS+NS A+ +P +IT+ A+ F Sbjct: 61 IMIDVVRRVAETIFIPFSVGGGISSVEDMRDVLLAGAEKISVNSAAVKNPKIITQGAEAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+G+D ++ K + L W QE ++ GAGEI LN ++ Sbjct: 121 GNQCVVLGMDVKKVEKSEKIPSGYEIVINGGRTYMGIDALWWAQEGERLGAGEICLNSID 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + GY+LE + E ++P+IASGG G +H + ++ D AL AS+ H Sbjct: 181 ADGTKEGYELELTALISENVNIPVIASGGGGIPQHLGDVLKEGKADAALIASMVHYGTYT 240 Query: 241 IGELKAYLATQGVEIR 256 I E+K +L +QG+ +R Sbjct: 241 IPEIKDHLKSQGISVR 256 >UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hisF n=36 Tax=cellular organisms RepID=HIS6_HALWD Length = 270 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 112/269 (41%), Positives = 147/269 (54%), Gaps = 13/269 (4%) Query: 1 MLAKRIIPCLDVR---DGQ--VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITAS 55 ML KRIIPC+DV DG V G+ F + E GD V +AK+Y GADE VF DITAS Sbjct: 1 MLTKRIIPCIDVDLDEDGNPAVYTGINFEDLEYTGDPVEMAKQYNMAGADEFVFLDITAS 60 Query: 56 SDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + GR VSRVA+ I IP V GGI++ +D L GADK+SIN+ AL P LIT Sbjct: 61 AVGRETMLETVSRVADEIFIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALETPELITT 120 Query: 116 LADRFGVQCIVVGIDTWYDAE---TGKYHVNQYTGD-----ESRTRVTQWETLDWVQEVQ 167 A FG QCIV+ +D + V+ + + T + L+WV E + Sbjct: 121 GASAFGSQCIVISVDARRRFDEQGENYLSVDGESCWFECTVKGGREGTGIDVLEWVTEAE 180 Query: 168 KRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDG 227 RGAGE+ +N ++ DG ++GYD+ V + P+IAS G G+ E F +A D Sbjct: 181 TRGAGELFINSIDADGTQDGYDIPLTSAVCDAVSTPVIASSGCGSPADMHEVFTEAGADA 240 Query: 228 ALAASVFHKQIINIGELKAYLATQGVEIR 256 LAAS+FH +I K YL +GV IR Sbjct: 241 GLAASIFHFGEYSIEATKEYLDERGVPIR 269 >UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hisF n=3 Tax=Bacteria RepID=C8PKX5_9PROT Length = 306 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 125/304 (41%), Positives = 165/304 (54%), Gaps = 51/304 (16%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 AKRIIPCLDV+DG+VVKGV F GD V +AKRY EEGADEL F DITAS GR Sbjct: 5 AKRIIPCLDVKDGRVVKGVNFVGLVDAGDPVEIAKRYNEEGADELCFLDITASHLGRDTI 64 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V RVA + IP V GGI++++D +++L+ G DKIS+NS A+ +P LI A++FG Sbjct: 65 VDVVERVARELFIPLTVGGGIRTIDDISRLLNVGCDKISLNSAAIKNPNLIDEAANKFGS 124 Query: 123 QCIVVGIDTWYDAET--------------------------------------------- 137 QC+V+ ID ++ Sbjct: 125 QCVVIAIDAKRNSIEISRGDLYGEARNSNGDLHGGMRNPDTNLGSEARNFGEILRGAQDE 184 Query: 138 ---GKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQL 193 G + Y T + L W +E Q+RGAGEI+L M+ DGV+NG++L Sbjct: 185 ILTGNGELCGYSVFINGGRLDTGRDALAWAKEAQERGAGEILLTSMDCDGVKNGFELNLT 244 Query: 194 KKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGV 253 + + +P+IASGGAG MEHF +AF A D LAAS+FH + I I LKAYL QG+ Sbjct: 245 R-IFSALDIPVIASGGAGKMEHFKDAFL-AGADACLAASIFHFREIEIKALKAYLQEQGI 302 Query: 254 EIRI 257 E+R+ Sbjct: 303 EVRL 306 >UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hisF n=7 Tax=cellular organisms RepID=HIS6_THEP1 Length = 254 Score = 275 bits (703), Expect = 1e-72, Method: Composition-based stats. Identities = 129/257 (50%), Positives = 167/257 (64%), Gaps = 7/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRII CLDV+DG+VVKG F N GD V L K Y+E G DELVF DITAS + R Sbjct: 1 MLAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFLDITASVEKRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V +VAE IDIPF V GGI E A++++ GADK+SIN+ A+ DP+LIT++A F Sbjct: 61 TMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVEDPSLITKIARTF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV ID G++ V Y+G ++ T DWV EV++RGAGEI+L ++ Sbjct: 121 GSQAVVVAIDAKKV--DGEFVVFTYSGKKN----TGILLRDWVVEVERRGAGEILLTSID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + GYD E ++ VR + +P+IASGGAG MEHFLEAF A SVFH + I+ Sbjct: 175 RDGTKAGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLAGADAALAA-SVFHFREID 233 Query: 241 IGELKAYLATQGVEIRI 257 + ELK YL GV +R+ Sbjct: 234 VRELKEYLKKHGVNVRL 250 >UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M910_CALMQ Length = 254 Score = 274 bits (701), Expect = 2e-72, Method: Composition-based stats. Identities = 112/256 (43%), Positives = 154/256 (60%), Gaps = 8/256 (3%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L +RIIPC+DV VVKGV F ++GD V LA RY EEGADEL DITA+ GR Sbjct: 7 LVRRIIPCMDVDADIVVKGVNFEGLRVMGDPVELASRYEEEGADELFLLDITATVQGRST 66 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V VA + IP V GGI+ +EDA GADK+SIN+ A+ DP+++ +L+ +G Sbjct: 67 FLETVRNVAAAVSIPLGVGGGIRGMEDADAAFKAGADKVSINTAAVKDPSIVAKLSREYG 126 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q +VV IDT + + R T +DW + V++ GAGE+++ ++ Sbjct: 127 SQSVVVAIDTRRINNEWRVFIMG------GRRETLLNAVDWARTVEELGAGELLVTSIDA 180 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG R GYD+E +++ + ++P+IASGGAG HFLE + D ALAASVFH +INI Sbjct: 181 DGTRAGYDIELYRRLADAVNIPVIASGGAGEPSHFLEVLKY--ADAALAASVFHMGVINI 238 Query: 242 GELKAYLATQGVEIRI 257 LKAYL+ G+ +RI Sbjct: 239 SILKAYLSELGIRVRI 254 >UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Thauera sp. MZ1T RepID=C4ZLR4_THASP Length = 226 Score = 271 bits (695), Expect = 1e-71, Method: Composition-based stats. Identities = 99/257 (38%), Positives = 146/257 (56%), Gaps = 31/257 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV+ G+VVKGV F GD V +A+RY E+ Sbjct: 1 MLAKRIIPCLDVKSGRVVKGVNFVELRDAGDPVEIARRYDEQ------------------ 42 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VAE + IP V GG++ +ED ++L+ GADK+S+N+ A+ +P L+ A + Sbjct: 43 --------VAEQVFIPLTVGGGVRVVEDVRRLLNAGADKVSMNTAAVNNPQLVFEAASKV 94 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID A GK+ V + G + T + ++W ++V+ GAGEI+L M+ Sbjct: 95 GSQCIVVAIDAKQTAP-GKWEVFTHGGRNN----TGLDAIEWARKVESLGAGEILLTSMD 149 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG ++G+DL + V + +P+IASGG GT+EH E + D LAAS+FH Sbjct: 150 RDGTKSGFDLALTRAVSDAVRIPVIASGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHT 209 Query: 241 IGELKAYLATQGVEIRI 257 + E K + +G+E+R+ Sbjct: 210 VREAKELMRARGIEVRL 226 >UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SCV5_HAHCH Length = 255 Score = 271 bits (695), Expect = 1e-71, Method: Composition-based stats. Identities = 94/260 (36%), Positives = 149/260 (57%), Gaps = 8/260 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIP L + G++VKG QF GD V A+ Y + ADELVF D+ A+ G Sbjct: 1 MLKKRIIPMLLLSQGRMVKGKQFSAFRDTGDPVSAARIYNAQFADELVFLDVDANRQGSD 60 Query: 61 --VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + +V+ +P V GG+ S+E +++ GADK+ I + AL +P LI + Sbjct: 61 FEQLLNLIDKVSSECFMPLSVGGGVNSVEQVRRLVQSGADKVVITTAALENPGLINDASA 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG QCIVVG+D E G Y + + G T+ E ++++++ +RGAGE ++N Sbjct: 121 IFGRQCIVVGLDVKR--EDGAYRLYSHCGRHK----TERELEEFIRDMTQRGAGEFIVNA 174 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 +++DG+ GYDLE +K + V P++A+GGAGT H AF++A+ D + AS+FH Sbjct: 175 VDRDGMMQGYDLEMIKCAKAVTDRPVLAAGGAGTFAHLTAAFQEANADAVVCASIFHFGD 234 Query: 239 INIGELKAYLATQGVEIRIC 258 N +++L G+ +++ Sbjct: 235 NNPIRARSHLLNAGIPMKLI 254 >UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKR3_FIBSS Length = 263 Score = 270 bits (690), Expect = 5e-71, Method: Composition-based stats. Identities = 103/256 (40%), Positives = 152/256 (59%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+I CLDVR+ +V KGV+F+ + IGD V + RY++EG DELVFYDITAS++ R Sbjct: 1 MLTKRLIVCLDVRNRKVTKGVKFKGNIDIGDPVEMGARYSDEGVDELVFYDITASAENRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + ++A+ + IPF V GGI++L+D + L GA+K+S+NS A+ P +I A F Sbjct: 61 CDMEMIRQIAKRVFIPFAVGGGIRNLDDMHEALLAGAEKVSVNSLAVLHPEIIAEGAKAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV+G+D + + K + + L W + ++ G GEI LN ++ Sbjct: 121 GRQCIVLGMDAKFVGVSDKIPSGYEVFIRGGRQAMGIDALQWAKRAEELGVGEICLNSID 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV+NGY+L + + VP+IASGGAGT H ++ FR D AL AS+ H Sbjct: 181 TDGVKNGYELTITDMIAKAVQVPVIASGGAGTPAHIVDLFRKTSADAALVASMVHFGDYT 240 Query: 241 IGELKAYLATQGVEIR 256 + +K + G+ +R Sbjct: 241 VPGIKGEMLAAGIPVR 256 >UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI6_KANKD Length = 265 Score = 266 bits (682), Expect = 4e-70, Method: Composition-based stats. Identities = 104/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L R+I CLDV G+VVKGV F+ + +GD V LA RY E+GADE++F DI A+ + R Sbjct: 5 LKSRVIVCLDVAHGRVVKGVNFKGLQDMGDPVELAIRYQEQGADEIIFLDIKATLEQRAN 64 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+RVAE + IPF V GG+ + D A+ L+ GADK+++NS A+ P L+ +A FG Sbjct: 65 ALEVVTRVAENLSIPFTVGGGLNTYADVAQFLNAGADKVALNSAAVKHPDLVDEIAKGFG 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 QC+VV +D + + ++Y +T + W+ E+++RGAGEI+L M+ Sbjct: 125 SQCVVVAVDLNQEQDQKTQGSSEYEVYINGGHTLTDLNAMQWLTEIEQRGAGEILLTAMH 184 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G+D E + +V + + +IASGGA HF + F A D ALAA +FH+ Sbjct: 185 RDGTGFGFDNELMSQVSKKLGIQVIASGGASKPAHFTDTFL-AGSDAALAAGMFHRGEFT 243 Query: 241 IGELKAYLATQGVEIRI 257 +G++K L GV +RI Sbjct: 244 VGQVKQELLNNGVAVRI 260 >UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococcoides RepID=A5FQU7_DEHSB Length = 268 Score = 266 bits (681), Expect = 5e-70, Method: Composition-based stats. Identities = 91/257 (35%), Positives = 141/257 (54%), Gaps = 1/257 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M +IIPCLDV+DG+VVK ++F + D A Y+++GADEL F DITA+ + Sbjct: 1 MKPIKIIPCLDVKDGRVVKEIKFTDMADARDPAEAAFVYSKQGADELAFLDITATIENSS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + WV ++ +P GGI++L+D + + G +++N+ + I + RF Sbjct: 61 IHTDWVKKIISKTSLPLIAGGGIRNLQDIENLFTLGVSNVALNTITPQNQEFIRKAVARF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I+V ID + G H T + E +DW ++V+ GAG I+L + Sbjct: 121 GSERIIVAIDGIKNPP-GNGHPRLETVMPNGDDTHNLELVDWAKQVEALGAGAILLTSKD 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG ++G+D+E ++ V +P+IASGGAG +E A + LAASVFH IIN Sbjct: 180 TDGTKDGFDMEMIRSVTRAVSIPVIASGGAGKLEDMYAAIIEGKAQAVLAASVFHSGIIN 239 Query: 241 IGELKAYLATQGVEIRI 257 I ELK YL ++G+ + I Sbjct: 240 ISELKTYLHSKGIPVNI 256 >UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hisF n=76 Tax=Bacteria RepID=HIS6_MYCBP Length = 267 Score = 263 bits (672), Expect = 5e-69, Method: Composition-based stats. Identities = 109/256 (42%), Positives = 146/256 (57%), Gaps = 2/256 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LA R+IPCLDV DG+VVKGV F N GD V LA Y EGADEL F D+TASS GR Sbjct: 13 LAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTFLDVTASSSGRAT 72 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R AE + IP V GG++++ D +L GADK+++N+ A+A L+ +A +FG Sbjct: 73 MLEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFG 132 Query: 122 VQCIVVGIDTWYDAETGKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 QCIV+ +D + + R T + + W G GEI+LN M+ Sbjct: 133 SQCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMD 192 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + G+DL L+ VR VP+IASGGAG +EHF A A SVFH + + Sbjct: 193 ADGTKAGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVLAA-SVFHFRELT 251 Query: 241 IGELKAYLATQGVEIR 256 IG++KA LA +G+ +R Sbjct: 252 IGQVKAALAAEGITVR 267 >UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Bacteria RepID=HIS4_LISW6 Length = 240 Score = 261 bits (668), Expect = 1e-68, Method: Composition-based stats. Identities = 67/244 (27%), Positives = 116/244 (47%), Gaps = 15/244 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D+++GQ V+ Q + + D + AK +A GA L D+ + +GR Sbjct: 1 MQIFPAIDLKNGQCVRLFQGDFSKKMIVNEDPIAQAKAFATGGATYLHIVDLDGALEGRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + ++ E +P V GGI+SL L G D++ I S AL +P + ++ Sbjct: 61 VNLEIIQKMKEAATVPVQVGGGIRSLAQVDYYLDSGIDRVIIGSAALTNPDFLHAAVQKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G I VGID N Y V+Q LD ++++K G I+ ++ Sbjct: 121 GP-KIAVGIDAK----------NGYVATSGWLEVSQVNYLDLAKQMEKVGVETIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G +LEQ+ +++ ++ LIASGG + EA + GA+A + I+ Sbjct: 170 RDGTLTGPNLEQMAALQKHVNIHLIASGGVSSRADL-EALSQLGLYGAIAGKALYNGHIS 228 Query: 241 IGEL 244 + ++ Sbjct: 229 MSDV 232 >UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJR2_DESAA Length = 262 Score = 258 bits (661), Expect = 9e-68, Method: Composition-based stats. Identities = 100/265 (37%), Positives = 142/265 (53%), Gaps = 13/265 (4%) Query: 1 MLAKRIIPCLDVRD---GQ-----VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI 52 ML KR+IP L +R G+ +V V F IGD V AK Y + ADELVF D+ Sbjct: 1 MLKKRLIPKLQMRAASFGKTKRMVLVTTVGFGPSTEIGDPVSQAKIYQAQAADELVFLDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 AS + R +++ AE I +P V GG++S+ED ++L+ GADK+SIN+ A+ P L Sbjct: 61 DASIEHRDALTDIIAKAAEEIFMPITVGGGVRSVEDCRRLLNHGADKVSINTGAMEIPEL 120 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I + +D FG QCIVV ID G Y V G S T + + W E Q RGAG Sbjct: 121 INQGSDMFGAQCIVVSIDYKKHP-NGAYEVFTRGGKSS----TGLDPVAWAVEAQHRGAG 175 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 EI+L +++DG R G +LE KV +P+I SGG G HF++ F A + Sbjct: 176 EILLTSIDRDGTRKGLNLELTAKVAGAVDIPVITSGGCGLASHFVDGFLVGKAHAVSAGT 235 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 F + N + ++ ++ G+ IR+ Sbjct: 236 YFCFKDENPMQTRSRISNAGIPIRL 260 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 62/244 (25%), Positives = 117/244 (47%), Gaps = 14/244 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRV 60 R+ P +DV+DGQ V+ + F + + +AK + E GA + D+ + G Sbjct: 1 MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + ++ +++P + GGI++LE+ ++L G ++ I + A+ +P I DRF Sbjct: 61 VNAETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IVVG+D + E +V+ L ++ G IV ++ Sbjct: 121 GAEHIVVGVDAK----------DGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDIS 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G ++EQ K + + + +IASGG M+ DA + GA+ +++ I+ Sbjct: 171 KDGMLAGPNVEQTKILSDKTGIDIIASGGMSCMDDLTH-INDAGIHGAIIGKAIYEKRID 229 Query: 241 IGEL 244 + E Sbjct: 230 LKEA 233 >UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase subunit n=3 Tax=Bacteria RepID=Q2LTH2_SYNAS Length = 254 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 99/257 (38%), Positives = 145/257 (56%), Gaps = 3/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M +I+PCLD+++G+VVKG+ F + GD V A Y EGADEL DI A+ + R Sbjct: 1 MKPIKIMPCLDMKEGRVVKGIHFVELKDAGDPVENAAFYQAEGADELAMLDIAATLENRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 WV++V+ V+ IP V GGI +LED +L GA KIS+NS A+ +P+L++ A +F Sbjct: 61 TRLEWVNKVSAVLTIPLTVGGGISTLEDIELVLQAGAAKISMNSAAVKNPSLVSEAAKKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I V ID + T + + W + Q+ GAG I+ M+ Sbjct: 121 GSEKITVAIDAR---RNSQMPSGFELVVSGGTLPVARDAVAWARTCQELGAGVILPTSMD 177 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG R GYD+E K + + +P++ASGGAG +E F EA + LAASVFH + ++ Sbjct: 178 GDGTRAGYDIEYTKAIADAVDLPVVASGGAGKLEDFYEAVQKGGASILLAASVFHYRTLS 237 Query: 241 IGELKAYLATQGVEIRI 257 I +K YLA +G+ + I Sbjct: 238 IRAVKQYLADRGLPVII 254 >UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW6_HODCD Length = 264 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 103/255 (40%), Positives = 151/255 (59%), Gaps = 6/255 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LA RIIPC+DV++G VVKG +F +G+ +A Y+ GADEL F D++ASS R + Sbjct: 5 LALRIIPCMDVKEGHVVKGSKFCGLVRVGEATLVANSYSVSGADELCFLDVSASSANRSI 64 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + +S+VAE IP V GG++ ++D +L GADK+SINS + P I R D+FG Sbjct: 65 LYATISQVAESCLIPLTVGGGVRRVKDVGDLLRAGADKVSINSAGVLSPEFIARCVDKFG 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QC+VV ID A G + V + G R T + L++ + + GAGEI+L +++ Sbjct: 125 SQCVVVSIDCK--ASDGAWEVCTHGG----ARPTGVDALEYACQAAQFGAGEILLTSVDR 178 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DGV+ GYDL LK V + VP+IASGG G + HF A + L AS+ H+ + + Sbjct: 179 DGVKAGYDLALLKAVSSLVSVPVIASGGGGELSHFALALIEGGASAVLTASLLHRNELTV 238 Query: 242 GELKAYLATQGVEIR 256 +LK +L + G+ +R Sbjct: 239 SQLKFFLGSCGIVVR 253 >UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winogradskyi Nb-255 RepID=Q3SPZ7_NITWN Length = 258 Score = 256 bits (655), Expect = 5e-67, Method: Composition-based stats. Identities = 89/257 (34%), Positives = 143/257 (55%), Gaps = 7/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVK-GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ML KR+IP +RDG++VK F N I G+ V AK Y + G DEL+ DI S+ R Sbjct: 1 MLKKRLIPKFLLRDGRLVKYTCFFDNERIAGNPVTTAKVYNDYGVDELIVLDIVPSAASR 60 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + + R++E I +PF V GG+K+ ED +L GADK+SINS A+ P + A Sbjct: 61 ARVEDIIGRMSEEIFMPFTVGGGVKTAEDVNALLRAGADKVSINSEAVRRPEFVREAART 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG QCI V ID G +H + Y + + ++W + GEI+++ + Sbjct: 121 FGDQCITVSIDYK---RIGSHHASVYI--DGGREHVALDPVEWALRCEDLHCGEILMSSI 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG GYDLE + + + VP+I SGG G+++H ++A +A +S+F Sbjct: 176 DRDGTMQGYDLEMINTLTKRLGVPMIVSGGCGSLQHAIDAL-EAGASAVAISSMFLFTDH 234 Query: 240 NIGELKAYLATQGVEIR 256 + +L+++LA++G+++R Sbjct: 235 SPIKLRSHLASRGLDVR 251 >UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=15 Tax=root RepID=HIS4_DEHSC Length = 244 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 60/250 (24%), Positives = 113/250 (45%), Gaps = 15/250 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 IIP +D+ G+ V+ Q D V A R+ GA L D+ ++DG+ Sbjct: 7 KIEIIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQ 66 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V+ + +A IP V GGI+S+E K+L G D++ + + A+ +P L+ + R Sbjct: 67 SVNFELIKEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICAR 126 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 + + V ID A GK + + T+ + L+ + ++K G + + Sbjct: 127 Y-ADSVAVSID----ARNGKVATRGWVTN------TEIDALELARSMKKLGIRRFIYTDI 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG + + ++ + +VP+IASGG ++ H +D +GA+ + + Sbjct: 176 SRDGTLSEPNFAAIRDLISAINVPVIASGGVSSLSHL-RLLKDIGAEGAIVGKAIYTGDL 234 Query: 240 NIGELKAYLA 249 N+ L+ Sbjct: 235 NLKRAFEDLS 244 >UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Prochlorococcus marinus RepID=A2C5V2_PROM3 Length = 500 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 88/255 (34%), Positives = 140/255 (54%), Gaps = 5/255 (1%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L+KRII LDV+ +++KGV+F +IGD + +A++YA+ G DEL++ D AS GR Sbjct: 15 LSKRIIARLDVKGNKIIKGVRFEGLRVIGDPLDMARKYAKAGIDELLYIDAVASLYGRNS 74 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + IP GGI++LEDA +LS GADKI+IN+ AL P LI+ L++ G Sbjct: 75 LIEVLKSTSSEVFIPITAGGGIRNLEDAKLLLSNGADKIAINTAALECPQLISELSNTLG 134 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QC+VV I + + + ES + + + W++ VQ GAGEI+L ++Q Sbjct: 135 SQCVVVSIQARASSSSSWDAMK-----ESGREKSGIDVIKWIENVQLLGAGEILLTSVDQ 189 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG D ++KV + +PLI SGG +A ++ + + H Q N+ Sbjct: 190 DGTCIKPDEILIQKVLPILKLPLIVSGGFSDPNQVYQALTNSRISAVAIGAALHYQKTNV 249 Query: 242 GELKAYLATQGVEIR 256 ++K+ L+ + IR Sbjct: 250 SDIKSMLSFNNIAIR 264 >UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hisF n=14 Tax=Bacteria RepID=HIS6_BEUC1 Length = 256 Score = 254 bits (650), Expect = 2e-66, Method: Composition-based stats. Identities = 103/254 (40%), Positives = 148/254 (58%), Gaps = 1/254 (0%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 A R++PCLDV G+VVKGV F + GD V LA+RY +GADE+ F D++AS+ GR Sbjct: 4 ALRVVPCLDVDGGRVVKGVNFLDLRDAGDPVELARRYDADGADEITFLDVSASTQGRATT 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 VS AE + +P V GG++++ D +L GADK+ +N+ A+A P L+T +A +G Sbjct: 64 LEMVSATAEQVFVPLTVGGGVRAVADVEALLRAGADKVGVNTAAIARPELLTEIAQHYGN 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q +V+ +D + T + ++W E RGAGE++LN ++ D Sbjct: 124 QVLVLSVDARRCPDGVVTDSGFEVTTHGGRTGTGIDAVEWAAEATSRGAGEVLLNSIDAD 183 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G+D+E ++ VR V PL+ASGGAGT+E F+ A A D LAASVFH + I Sbjct: 184 GTTAGFDVEMIEAVRAVVDTPLVASGGAGTVEDFVAA-ARAGADAVLAASVFHYGTLTIS 242 Query: 243 ELKAYLATQGVEIR 256 E+KA L G E+R Sbjct: 243 EVKAALRDAGFEVR 256 >UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Synechococcus sp. CC9311 RepID=Q0IDQ9_SYNS3 Length = 255 Score = 254 bits (649), Expect = 3e-66, Method: Composition-based stats. Identities = 94/256 (36%), Positives = 144/256 (56%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP LD++ G ++KGVQ +GD + AKRY+E GADEL+F D+ AS R Sbjct: 1 MRNLRIIPRLDIKSGTLIKGVQMEGWRKVGDPILAAKRYSEYGADELLFMDVVASLYERN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V +V + IP V GGI+ ++D +LS GADK+S+N+ AL P LI ++DR+ Sbjct: 61 TLHEIVEQVCSNVFIPVTVGGGIRKIKDVETLLSRGADKVSVNTGALLKPELINEISDRY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q V+ ++ E + ++ + E ++WV+E + RGAGEIVL ++ Sbjct: 121 GSQATVLTVECLKCGEKSWEAL-----TDNGRNRSGREVIEWVKEAENRGAGEIVLTSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 QDG G+D++ + V + ++P+IASGG G H +E + DV GA A H + ++ Sbjct: 176 QDGRGYGFDIDLVDIVSQAVNIPIIASGGFGKPSHIVELIKSTDVSGAAIAQALHWEKVS 235 Query: 241 IGELKAYLATQGVEIR 256 E++ L V +R Sbjct: 236 FSEIRDSLRDNNVFLR 251 >UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picrophilus torridus RepID=Q6KZD5_PICTO Length = 249 Score = 253 bits (648), Expect = 4e-66, Method: Composition-based stats. Identities = 94/257 (36%), Positives = 150/257 (58%), Gaps = 8/257 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRII LDVR+G+VVKGV+F + + GD V A Y ++GADE+VF DI+A+ + R Sbjct: 1 MLAKRIIAALDVRNGRVVKGVRFMDIKDAGDPVENAVIYQDQGADEIVFLDISATDEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V V+ ++IPF V GGI+S++ A +L G DK+ +N+ A+ +P +I ++ Sbjct: 61 IMIDLVKSVSRELNIPFTVGGGIRSVKTALNLLREGCDKVFLNTYAIENPWIIKEISRET 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G +V+ +D Y Y+V + G + + + +W+ + GAGEI+L ++ Sbjct: 121 GSANLVIAVDAMY---NNGYYVYKNAGRIN----SGLKLNEWLPMAEYLGAGEILLTSID 173 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG G+D + + + +P+IASGGAG EHFL+AF A S+ H +I Sbjct: 174 SDGTMKGFDNRLISEAASMIDIPVIASGGAGKPEHFLDAFMAGASGALAA-SILHFKINT 232 Query: 241 IGELKAYLATQGVEIRI 257 + ++K YL + GV +R+ Sbjct: 233 VNDIKRYLRSNGVNVRL 249 >UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PWX6_9BACT Length = 243 Score = 253 bits (647), Expect = 4e-66, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 118/246 (47%), Gaps = 15/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++ G+ V+ Q + E D V +AK + ++GA L D+ + DG + Sbjct: 3 IFPAIDLKGGKCVRLTQGKKDEETVFSDDPVDMAKSWEDQGAQYLHVVDLDGAFDGLPKN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S V ++ I+IP GG+++ E +L G +++ I + AL P+ + L F Sbjct: 63 LSIVEQIVNNINIPIEFGGGLRTTESVKSVLDLGVERVIIGTKALDSPSWVEELCSLFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + VGID A+ GK V+ + T +++ +D+ +E++K I+ +++D Sbjct: 123 -RVAVGID----AKNGKVAVHGW------TSLSEKTAIDFAREMEKFSPCAIIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G ++E LK++ P+IASGG +++ E V+G + + I Sbjct: 172 GMLQGPNIESLKELLSSIKTPVIASGGISSLKDI-EYICQLPVEGMIVGKALYTGHIKFS 230 Query: 243 ELKAYL 248 E K Sbjct: 231 EAKQLC 236 >UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Arcobacter butzleri RM4018 RepID=A8ESN1_ARCB4 Length = 256 Score = 252 bits (644), Expect = 9e-66, Method: Composition-based stats. Identities = 90/254 (35%), Positives = 140/254 (55%), Gaps = 5/254 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+IPCL + G + K +F+ IGD + K + E+ DEL+F DI AS + R Sbjct: 2 MLQKRVIPCLLLHKGGLYKTEKFKKPTYIGDPINAIKIFNEKEVDELMFIDIDASVEDRE 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + +A +P C GG+K++E KI + G +K+SI+S A+ +P LI A F Sbjct: 62 PNYKMIEDIASECFMPLCYGGGVKNIEQMKKIYALGVEKVSISSQAIINPNLIKEAARLF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q ++V ID D K + + T+ +D++++V+ GAGEIV+N + Sbjct: 122 GNQSVIVTIDIKKDFWGNKK-----IFINNGKKNTKLNPIDFIKQVESLGAGEIVINSCD 176 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ GYD+E LK+++E VP+IA GGAG + H + F + VD S+F Q Sbjct: 177 NDGIMKGYDIELLKEIKENTKVPIIALGGAGNLNHIKDVFESSKVDAVACGSMFVYQGPL 236 Query: 241 IGELKAYLATQGVE 254 G L +Y + Q ++ Sbjct: 237 KGVLISYPSYQKIQ 250 >UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B9F8_THEAS Length = 253 Score = 251 bits (643), Expect = 1e-65, Method: Composition-based stats. Identities = 90/256 (35%), Positives = 154/256 (60%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ KRIIP ++ ++VKG FR+H +GD V A +GA+E+V D+ A+ +GR+ Sbjct: 1 MMPKRIIPQFLLKGSRLVKGTSFRDHVDVGDPVSQAMIQDAQGAEEIVLVDVDATREGRL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VD S +SR+ E +P V GG+ +++DA+++ GADK+ +N+ A+ +P++I LA+RF Sbjct: 61 VDTSLISRMVERCRLPIAVGGGVGNVDDASRLFVAGADKVIVNTAAVLNPSMIRPLAERF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV +D +++ G V S + + ++ ++ GAGE ++ ++ Sbjct: 121 GAQSVVVSLDLKRNSKRGWVPV-----VRSGEEEVDLDFVYLLEALEANGAGEFIVTSVD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G +G+DL+ LK VREV VPLIASGGAG H +E F D++G + + + Sbjct: 176 REGTLSGFDLDMLKVVREVVKVPLIASGGAGNYLHLVELFLSIDLEGVGIGKMLALRDYD 235 Query: 241 IGELKAYLATQGVEIR 256 + +KA+L +G+ +R Sbjct: 236 VVRIKAFLKGRGIPVR 251 >UniRef50_P72139 Putative imidazole glycerol phosphate synthase subunit hisF2 n=9 Tax=cellular organisms RepID=HIS62_PSEAE Length = 251 Score = 251 bits (643), Expect = 1e-65, Method: Composition-based stats. Identities = 88/255 (34%), Positives = 141/255 (55%), Gaps = 5/255 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ +R+IPCL ++D +VK V+F+ + +GD + + + E+ DEL+ DI AS + Sbjct: 1 MVRRRVIPCLLLKDRGLVKTVKFKEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQE 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ VA +P C GGIK+LE A KI S G +K+SIN+ AL D +LI R+AD+F Sbjct: 61 PNYELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V ID G E+ TR + L+W Q +++ G GEI LN ++ Sbjct: 121 GSQSVVGSIDCRKGFWGG-----HSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DGV+ G+D ++ + HVP+IA GGAG++ ++ F V A S+F + Sbjct: 176 RDGVQKGFDNALVENIASNVHVPVIACGGAGSIADLIDLFERTCVSAVAAGSLFVFHGKH 235 Query: 241 IGELKAYLATQGVEI 255 L +Y +++ Sbjct: 236 RAVLISYPDVNKLDV 250 >UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_THEYD Length = 244 Score = 251 bits (643), Expect = 1e-65, Method: Composition-based stats. Identities = 64/254 (25%), Positives = 121/254 (47%), Gaps = 14/254 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IIP +D++DG+ V+ Q + E + A R+ EGA+ L D+ + +G++ Sbjct: 1 MQIIPAIDLKDGKCVRLRQGKFSEVTVYYDNPEDAALRWQNEGAEVLHVVDLDGAKEGKI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ E V GGI+ +ED +LS G D++ + + A+ P + + RF Sbjct: 61 GNLPSIKKIREAFRGNIEVGGGIRRIEDIELLLSVGIDRVIVGTIAVQSPDFVKEVCKRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I+VGID A+ G V + VT+ ++ ++Q G I+ ++ Sbjct: 121 P-KKIIVGID----AKDGLVAVKGWV------EVTEIRAIELALKMQDYGIWGIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G ++E K + E VP+IASGG ++E + + G + + I+ Sbjct: 170 RDGMLTGPNIEATKALVESVKVPVIASGGVSSIEDIRKLAEIPQLWGVITGKAIYSGAID 229 Query: 241 IGELKAYLATQGVE 254 + E + GV+ Sbjct: 230 LKEALRIIKGDGVK 243 >UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase subunit HisF n=1 Tax=Campylobacterales bacterium GD 1 RepID=B6BGE0_9PROT Length = 254 Score = 251 bits (642), Expect = 1e-65, Method: Composition-based stats. Identities = 87/257 (33%), Positives = 147/257 (57%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M R+I +D+++ +KG+ +G+ +A RY E+G DE+V D AS R Sbjct: 1 MKKIRVIARIDIKNEHTIKGIHLEGLRKVGNPNEMALRYYEDGIDEIVLMDAVASLYDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 K + + E I IP V GG+++L+D + L+ GADK++IN+ A+ +P+ IT + +F Sbjct: 61 SLKDVIVKACEDIFIPITVGGGLRNLQDIQEALNSGADKVAINTQAIREPSFITTASKQF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI+ I + GK+ G E T + L W +EVQ+ GAGEI+L ++ Sbjct: 121 GSQCIISSI-VAKKIDDGKWEAYIENGRE----PTGVDVLAWAKEVQELGAGEIMLTSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G + G+DLE K V E+ ++P+I+SGGAG+ + + +D+D AS+ H ++ + Sbjct: 176 KEGTKKGFDLELNKAVAELVNIPVISSGGAGSTKDIVHLCESSDIDAVAIASILHYKLES 235 Query: 241 IGELKAYLATQGVEIRI 257 + E+K L +++RI Sbjct: 236 VSEIKKTLINNKIKVRI 252 Score = 43.5 bits (102), Expect = 0.007, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 41/102 (40%), Gaps = 1/102 (0%) Query: 31 DIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAA 90 D++ AK E GA E++ I + D VAE+++IP +GG S +D Sbjct: 153 DVLAWAKEVQELGAGEIMLTSIDKEGTKKGFDLELNKAVAELVNIPVISSGGAGSTKDIV 212 Query: 91 KILSF-GADKISINSPALADPTLITRLADRFGVQCIVVGIDT 131 + D ++I S ++ + I V ID Sbjct: 213 HLCESSDIDAVAIASILHYKLESVSEIKKTLINNKIKVRIDA 254 >UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Bacteria RepID=C5BRY3_TERTT Length = 259 Score = 251 bits (642), Expect = 2e-65, Method: Composition-based stats. Identities = 98/254 (38%), Positives = 143/254 (56%), Gaps = 5/254 (1%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + R I LDV+ Q++K + ++GD AKRY E+GADEL++ D+ AS GR Sbjct: 8 STRFIARLDVKGDQLIKAIHLEGLRVVGDPQIYAKRYYEQGADELLYIDLVASLYGRNKL 67 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 K VSR A+ I IP V GGI+S+ED ++L+ GADK++IN+ A+A+P LI ++A RFG Sbjct: 68 KDIVSRTAQDIFIPLTVGGGIRSVEDVTELLAAGADKVAINTAAVANPALIEQVALRFGS 127 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 QC+V+ I+ E ++ V ES + + + W +E +RGAGEI+L ++Q+ Sbjct: 128 QCMVLSIEAKRLGED-RWEVYTDCARES----SGRDVIAWAKEAVERGAGEILLTSIDQE 182 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G R G+D V E VP+IASGG G EH + A H + I Sbjct: 183 GTRKGFDTALTAAVAETVRVPVIASGGYGQPEHINAITHQGSANAIAFADALHFERETIA 242 Query: 243 ELKAYLATQGVEIR 256 LK+Y A G+ +R Sbjct: 243 SLKSYGAEAGLRVR 256 >UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Halothermothrix orenii H 168 RepID=HIS4_HALOH Length = 237 Score = 250 bits (639), Expect = 4e-65, Method: Composition-based stats. Identities = 64/247 (25%), Positives = 114/247 (46%), Gaps = 14/247 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++DG V+ + F + V +A + + GA L D+ + G Sbjct: 1 MEVIPAVDIKDGSCVRLKKGDFNKRRVYSTSPVDVALYWEKHGASRLHIVDLDGAKSGWP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + +A ++IP V GGI+SL+ K L G D+I + + AL +P L+ R D F Sbjct: 61 THLKTIREIALRVNIPLQVGGGIRSLKVIKKYLDSGVDRIILGTVALKNPELVKRALDNF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVVG+D A GK + + +Q D + E+++ G + +N Sbjct: 121 GSNRIVVGVD----ARGGKVATEGW------LKTSQVTVEDIISEMEEVGVKTFIYTDIN 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G D+E +K+V + +IASGG + + + + + A+ ++ + Sbjct: 171 RDGMLKGPDIEGIKRVLKSTKARIIASGGISSRQDLIN-LKAIGIKAAIVGKALYEGNLP 229 Query: 241 IGELKAY 247 + L Y Sbjct: 230 LEVLNQY 236 >UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E201_GEOLS Length = 282 Score = 250 bits (638), Expect = 5e-65, Method: Composition-based stats. Identities = 94/286 (32%), Positives = 141/286 (49%), Gaps = 33/286 (11%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP LD++ +VKG+ ++GD + A Y E GADEL++ DI AS R Sbjct: 1 MKPVRIIPRLDIKGPNLVKGIHLEGLRVLGDPIAFAHYYYENGADELIYSDIVASLYQRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + IP +AGG+++L D K L GADK+ IN+ A+ +P I + F Sbjct: 61 SILDLVTETSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVRVF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVV ++ + + E+ + + E + WVQ V++ GAGEI+L +N Sbjct: 121 GSSTIVVAVEVVRNDDNSLIAY-----TENGRQSSGIEAVSWVQRVEELGAGEILLTSIN 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK---- 236 +G +GYD++ + +V +P+IA GGAG EH E F +DV A AS+FH Sbjct: 176 AEGTGDGYDMDLINRVVSAVSIPVIAHGGAGKPEHVREVFATSDVRAAAVASMFHYYAKK 235 Query: 237 ------------------------QIINIGELKAYLATQGVEIRIC 258 I+I ELK YL+ G+ R+ Sbjct: 236 LSADMNPVEGNLDFLRSGKSFSRVSEISIVELKQYLSKHGIVCRLV 281 >UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Cyanobacteria RepID=HIS4_PROMS Length = 255 Score = 248 bits (634), Expect = 1e-64, Method: Composition-based stats. Identities = 58/251 (23%), Positives = 119/251 (47%), Gaps = 16/251 (6%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ +G+ V+ + + + + A+ + EGA + D+ A+ G + Sbjct: 3 LIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSPTN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++A+ ++IP + GGI+S E ++ S+G +K+ + + A+ + L+ L+++F Sbjct: 63 DKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I+VGID A+ GK + + D V+E ++ +N D Sbjct: 123 -RIIVGID----AKDGKVSTRGW------LEQSNIFATDLVKEFSSFKIASFIVTDINTD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQIIN 240 G G + E +K + E+ +P+IASGG G++ L F ++ + G + ++ Sbjct: 172 GTLEGTNEEFIKSILEITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFT 231 Query: 241 IGELKAYLATQ 251 I E L+ + Sbjct: 232 INEANNVLSAE 242 Score = 45.8 bits (108), Expect = 0.001, Method: Composition-based stats. Identities = 23/125 (18%), Positives = 51/125 (40%), Gaps = 7/125 (5%) Query: 5 RIIPCLDVRDGQV-VKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 RII +D +DG+V +G +++ D L K ++ + DI ++ Sbjct: 123 RIIVGIDAKDGKVSTRGWLEQSNIFATD---LVKEFSSFKIASFIVTDINTDGTLEGTNE 179 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKIL---SFGADKISINSPALADPTLITRLADRF 120 ++ + E+ DIP +GG+ S+ D ++ + G + + + I + Sbjct: 180 EFIKSILEITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFTINEANNVL 239 Query: 121 GVQCI 125 + + Sbjct: 240 SAERL 244 >UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase subunit hisF2 n=17 Tax=delta/epsilon subdivisions RepID=HIS62_CAMJJ Length = 248 Score = 248 bits (634), Expect = 1e-64, Method: Composition-based stats. Identities = 95/257 (36%), Positives = 141/257 (54%), Gaps = 10/257 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML RIIPC+ +++GQ+VK ++F++ IG + + Y DEL+ DI AS G Sbjct: 1 MLKTRIIPCVLLKNGQLVKSIEFKDFRTIGHLTSTMRIYNARNVDELIILDIDASKSGE- 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +D + +A+ +P + GGIK+LED KIL+ GADKISINS AL D I++ A+RF Sbjct: 60 IDFESIEDLAKECFMPLTIGGGIKTLEDIQKILNLGADKISINSKALEDMDFISKAANRF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV ID + G++ V R + + L+ E +K+GAGE++L ++ Sbjct: 120 GSQCIVCSIDVKR--KGGQFCVY------DRGNLLEKSPLELALEYEKKGAGELLLTSVD 171 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G GYDLE LK + +PLI +GG +EA + D A +FH Sbjct: 172 FEGRAKGYDLELLKIFQNKLKIPLIINGGLSNPSDGVEAL-NLGADALAGAYIFHFSKYT 230 Query: 241 IGELKAYLATQGVEIRI 257 ++K LA QG +R+ Sbjct: 231 PKDVKEELARQGFAVRL 247 >UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Bacillales RepID=HIS4_BREBN Length = 249 Score = 247 bits (632), Expect = 2e-64, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 102/255 (40%), Gaps = 16/255 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ + P +D+R G+ V+ Q + +AKR+ E+GA + D+ + +G Sbjct: 1 MSFIVYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + + + +A I +P V GGI++ E A L G ++ + + A+ D R+ Sbjct: 61 KPANAAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQ 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G I +G+D N T + + + + GA + Sbjct: 121 NDG-DKIAIGLDCR----------NGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHK 236 + +DG G ++E++ + +IASGG ++ L A V GA+ + Sbjct: 170 IARDGTMTGPNVEEIAALAMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYT 229 Query: 237 QIINIGELKAYLATQ 251 + E + + Sbjct: 230 DAFTLEEALQRMEGR 244 >UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hisF n=24 Tax=cellular organisms RepID=HIS6_HALS3 Length = 273 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 115/272 (42%), Positives = 151/272 (55%), Gaps = 22/272 (8%) Query: 2 LAKRIIPCLDVR---DGQ--VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 L KR+IPC+DV DG+ V GV F GD V +AKRY E GADE VF DITAS+ Sbjct: 3 LTKRVIPCIDVDLDDDGEPAVYTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASA 62 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 +GR VS VA+ + IP V GGI+ +D + L GADK+SINS A+ADP+L+ R Sbjct: 63 EGRETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRG 122 Query: 117 ADRFGVQCIVVGIDTWY------------DAETGKYHVNQYTGDESRTRVTQWETLDWVQ 164 A FG QCIV+ +D D E+ + + G E T + ++WVQ Sbjct: 123 AKAFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREG----TGMDAIEWVQ 178 Query: 165 EVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD 224 E Q+RGAGE+ +N ++ DG ++GYD+ V + P+IAS G G + DA Sbjct: 179 EAQRRGAGELFVNSIDADGTQDGYDVPLTAAVCDAVSTPVIASSGCGAPG-DMADAYDAG 237 Query: 225 VDGALAASVFHKQIINIGELKAYLATQGVEIR 256 D ALAAS+FH +I E K LA G IR Sbjct: 238 ADAALAASIFHFDEYSIAETKETLADAGYPIR 269 >UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Chlorobiaceae RepID=HIS4_PROA2 Length = 261 Score = 245 bits (627), Expect = 1e-63, Method: Composition-based stats. Identities = 61/249 (24%), Positives = 109/249 (43%), Gaps = 18/249 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 ML IIP +D++DG+ V+ + + + +A + ++ A L D+ A+ Sbjct: 1 ML---IIPAIDIKDGKCVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALT 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G +V+ + + +DIP V GGI+S ED + L G ++ I S A+ +P LI L Sbjct: 58 GTMVNFEKIREIVATLDIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELL 117 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 F IVVGID AE G + + T + + + E++K G I+ Sbjct: 118 ATFSPSQIVVGID----AENGIPKIKGW------TESSSMQDYELALEMKKLGVKRIIYT 167 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFH 235 +++DG+ G E ++ + + ASGG + + + VD + + Sbjct: 168 DISRDGMMQGVGYESTRRFAMKAGMRVTASGGVTSSDDLKKLQTLEQYGVDSVIVGKALY 227 Query: 236 KQIINIGEL 244 + +L Sbjct: 228 ESNFPCQQL 236 >UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7I5_9DELT Length = 289 Score = 244 bits (625), Expect = 2e-63, Method: Composition-based stats. Identities = 79/238 (33%), Positives = 117/238 (49%), Gaps = 5/238 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + RIIP LD++ +VKG+ F ++G A+ Y E GADEL F D AS R Sbjct: 1 MKFRIIPRLDIKGPNLVKGIHFEGLRVLGKPEDFARHYYENGADELFFQDAVASLYDRNS 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R + I IP CV GG++S++D +L GADK++IN+ A+ P LI + FG Sbjct: 61 LHDIVKRTSSEIFIPLCVGGGLRSVDDIRAVLRAGADKVAINTEAIKRPELIREASVAFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 IVV I+ A + +Y T ++W + + GAGE+++ ++Q Sbjct: 121 SSTIVVSIEAIRRANGEWEALVEY-----GRETTGVNAVEWAKRACELGAGELMITSIDQ 175 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +G GYD+E + + VP+IA GG G+ D ASV H + I Sbjct: 176 EGTGKGYDIELTRAIASAVSVPVIAGGGCGSPADAANVITQGRADAVSMASVLHYKTI 233 >UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Euryarchaeota RepID=HIS4_METBU Length = 246 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 65/257 (25%), Positives = 130/257 (50%), Gaps = 17/257 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +IP +D++ G+ V+ VQ + D V +A + +GA L D+ + +G Sbjct: 1 MSFEVIPAVDMKGGKCVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIEG 60 Query: 59 RVVDKSWVSRVAEVI---DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + + ++ E I V GGI+S EDAA +L G DK+ +++ AL DP LI + Sbjct: 61 NRTNAPIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLLDIGIDKVILSTAALKDPELIKK 120 Query: 116 LADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIV 175 L+D FG + I V +D ++ GK + + T+ ++ ++ + +++GAG I+ Sbjct: 121 LSDEFGSEHINVALD----SKNGKISIEGW------TKESEHTAVEMGSQFEEKGAGSIL 170 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 ++ +G+ NG + + +++ +P+IASGG T+E + ++ G + S + Sbjct: 171 FTNIDSEGLLNGVNPKPTEELVNAVTIPVIASGGVTTLEDIV-TLKNTGAAGVVVGSALY 229 Query: 236 KQIINIGELKAYLATQG 252 K+ + E ++ + Sbjct: 230 KKRFTLTEAINIISDKN 246 >UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_DESAP Length = 262 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 65/260 (25%), Positives = 119/260 (45%), Gaps = 19/260 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 ML IIP +D+R G+ V+ Q R D V +A+ + E+GA L D+ + Sbjct: 1 ML---IIPAVDLRGGRCVRLFQGRADQETVYSTDPVAVARTWEEQGARRLHVVDLDGAFT 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ + V + + ++IP V GGI++ E+ L G D++ + + AL +P + + Sbjct: 58 GKPQNSGVVLDIVKSVNIPVQVGGGIRNPENVKCYLEHGVDRVILGTAALTNPEFLDAVV 117 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +G + IVVG+D G+ V + + + L +++E+ +RG +V Sbjct: 118 AAYG-ERIVVGVDC----RDGRVCVQGW------EQTAATDVLPFLEELVRRGVRRVVFT 166 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFH 235 + +DG G +LE++ +V + +IASGG +E L+ VD + + Sbjct: 167 DVKRDGTLEGPNLEEIARVAAHTELKVIASGGVSRLEDLRALKKLEHLGVDSVIIGKALY 226 Query: 236 KQIINIGELKAYLATQGVEI 255 I + E A + + Sbjct: 227 AGTITLAEALALERKEKDNV 246 >UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Proteobacteria RepID=A6T0B3_JANMA Length = 253 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 79/247 (31%), Positives = 136/247 (55%), Gaps = 5/247 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLA R++PCL + G +VK VQF+ IGD V + + ++ DEL+ DITA+++ R Sbjct: 1 MLAIRVMPCLLMDQGALVKTVQFKKPTYIGDPVNAVRIFNQKEVDELLLIDITATTEKRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +D + ++ +P C GG+ +L D ++ G +KIS+++ A+ +P L+ A F Sbjct: 61 IDFETLEKLVTECFMPICYGGGVDNLVDMRRLYHLGIEKISLSAAAITNPELVREAAAEF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D + GK+ V + G T+ ++ +E+++ GAGEI+L ++ Sbjct: 121 GNQAIVVTLDVKKNL-FGKHTVRTHQGK----TDTKRSPVEVAREMEQAGAGEILLYSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G+DL+ ++ V +P+IA GGAG + H A +A S+ Q + Sbjct: 176 KDGTWSGFDLDLIQNVTRAVGIPVIACGGAGELAHLRSAVNEAGASAVAIGSMAVFQAKD 235 Query: 241 IGELKAY 247 +G L + Sbjct: 236 LGVLIKF 242 >UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Roseburia RepID=C7GBG4_9FIRM Length = 252 Score = 244 bits (623), Expect = 3e-63, Method: Composition-based stats. Identities = 95/258 (36%), Positives = 136/258 (52%), Gaps = 6/258 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L + +VKGV F + + ++P K Y DEL+ DI A+++ R Sbjct: 1 MLKVRVIPTLLYKSVGLVKGVGFNSWRRVDTVLPAIKVYNMREVDELILLDIEATNEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + + +PFCV GGI ++ +L GADK++INS A + +LIT A F Sbjct: 61 PDYDEIRDFSRECFVPFCVGGGICHIDQIKNLLRAGADKVAINSAAYDNLSLITEGAKLF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV ID G+YH + G + T W DW+ +V + GAGEI+L + Sbjct: 121 GSQCIVASIDCRK--IDGEYHCFSHNG----SVDTGWLLQDWIIKVVEAGAGEILLTSVE 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG GYD+E +K + +VP+IASGGAG EH +A ++ AAS++H Sbjct: 175 LDGTMEGYDVEMIKIATSLVNVPVIASGGAGNYEHMRKAVQEGGASAVAAASIYHFTEQT 234 Query: 241 IGELKAYLATQGVEIRIC 258 E K YL GV +R+ Sbjct: 235 PKEAKEYLGEHGVAVRMI 252 >UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Firmicutes RepID=HIS4_CLOD6 Length = 240 Score = 243 bits (620), Expect = 6e-63, Method: Composition-based stats. Identities = 54/247 (21%), Positives = 119/247 (48%), Gaps = 15/247 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++D + V+ Q + + + +A ++ EGA+ + D+ + V+ Sbjct: 3 IFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A IDIP V GG++ E +++ G ++ + S A+ + L+ L + + Sbjct: 63 TKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY-K 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IVV ID A+ GK V + V+ ++L ++++K G IV +++D Sbjct: 122 EKIVVSID----AKDGKVAVRGWEV------VSNVDSLTLCKQLEKIGVQTIVYTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G + + +++ + + +IASGG ++E ++ + ++ GA+ + + I+ Sbjct: 172 GMLQGPNFDIYERIAKETSLNVIASGGVTSIED-VKRLKAMNLYGAIIGKALYDKKIDFK 230 Query: 243 ELKAYLA 249 E + Sbjct: 231 EAQQLCL 237 Score = 51.6 bits (123), Expect = 3e-05, Method: Composition-based stats. Identities = 22/115 (19%), Positives = 49/115 (42%), Gaps = 4/115 (3%) Query: 3 AKRIIPCLDVRDGQV-VKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++I+ +D +DG+V V+G + ++ D + L K+ + G +V+ DI+ + Sbjct: 121 KEKIVVSIDAKDGKVAVRGWEVVSNV---DSLTLCKQLEKIGVQTIVYTDISKDGMLQGP 177 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + R+A+ + +GG+ S+ED ++ + I Sbjct: 178 NFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEA 232 >UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Salinibacter ruber DSM 13855 RepID=HIS4_SALRD Length = 258 Score = 242 bits (619), Expect = 8e-63, Method: Composition-based stats. Identities = 53/240 (22%), Positives = 116/240 (48%), Gaps = 16/240 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+RDG+ V+ Q D V +AK + + A L D+ A+ + Sbjct: 4 VIPAIDIRDGRCVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEHN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + +DIP + GGI+S++ L G ++ + + A+ +P + R ++F Sbjct: 64 RDVIGKMCDALDIPIQLGGGIRSMDQIEAALDRGVYRVILGTAAVRNPDFVERAVEQFSA 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV ID A G+ V + T + + + + +++++RG +V +++D Sbjct: 124 RRVVVSID----ARDGEVRVQGW------TEGSGLDAVAFAKDMEQRGVRRLVYTDISRD 173 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLE--AFRDADVDGALAASVFHKQII 239 G +G +++ + + R++ H + ASGG G + L+ + VD + + ++ Sbjct: 174 GTMDGPNIQAYRTLGRQLAHAKVTASGGVGEHDDLLDIQTLQPYGVDSVIVGTALYENRF 233 Score = 47.4 bits (112), Expect = 5e-04, Method: Composition-based stats. Identities = 24/111 (21%), Positives = 43/111 (38%), Gaps = 6/111 (5%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 A+R++ +D RDG+V VQ D V AK + G LV+ DI+ + Sbjct: 123 ARRVVVSIDARDGEV--RVQGWTEGSGLDAVAFAKDMEQRGVRRLVYTDISRDGTMDGPN 180 Query: 63 KSWVSRVAEVI-DIPFCVAGGI---KSLEDAAKILSFGADKISINSPALAD 109 + + +GG+ L D + +G D + + + + Sbjct: 181 IQAYRTLGRQLAHAKVTASGGVGEHDDLLDIQTLQPYGVDSVIVGTALYEN 231 >UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=91 Tax=Bacteria RepID=HIS4_SYNJB Length = 261 Score = 242 bits (619), Expect = 8e-63, Method: Composition-based stats. Identities = 66/242 (27%), Positives = 112/242 (46%), Gaps = 14/242 (5%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ G+ V+ Q ++ D + A+ +A +GA L D+ + G V+ Sbjct: 10 VIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVN 69 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+ + IP V GGI+SLE A ++L G D++ + + A+ DP + + F Sbjct: 70 LPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPG 129 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + VGID T + VQ VQ +GA I+ +++D Sbjct: 130 -RVWVGIDAR----------QGQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRD 178 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G +LEQL+++ V VP+IASGG G++ L + GA+ + I++ Sbjct: 179 GTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQ 238 Query: 243 EL 244 E Sbjct: 239 EA 240 >UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Bacilli RepID=HIS4_STRSV Length = 242 Score = 242 bits (618), Expect = 9e-63, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 117/249 (46%), Gaps = 15/249 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +I+P +D++DGQ V+ + F ++ D++ A+ + E G + D+ + +G Sbjct: 1 MSMKILPAIDIKDGQAVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALEG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R ++ ++++ + V GGI+SLE L+ G D++ I S A+ +P + + Sbjct: 61 RAANRDLIAQIKAETGLAIQVGGGIRSLEQIEDYLAVGIDRVIIGSMAVKNPEFVEAALE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 RFG IV+GID E + + + ++K G V Sbjct: 121 RFGSGKIVIGIDAK----------EGLVATEGWLETSNQDYISLALAMEKIGVRLFVYTD 170 Query: 179 MNQDGVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +++DG G +++ +K + + H +IASGG + + E + + GA+ ++ Sbjct: 171 VDRDGTLTGPNIQHYQKLLASLKHAQVIASGGIQSADDLEE-MKKLGLAGAIVGKAYYSG 229 Query: 238 IINIGELKA 246 I++ ++K Sbjct: 230 RISLEQIKE 238 >UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Persephonella marina EX-H1 RepID=HIS4_PERMH Length = 241 Score = 241 bits (617), Expect = 1e-62, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 114/250 (45%), Gaps = 16/250 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDG 58 L +IP +D++DG+ V+ + + D V +AK++ E+GA L D+ + +G Sbjct: 3 LRSFVIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + V + + + IP GG++S E I+ G +++ I S A + R+ Sbjct: 63 KPKNIDIVKDIVKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVS 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 + ++VGID A+ GK + + T++ LD+ + + Sbjct: 123 AYPG-KVIVGID----AKDGKVAIKGW------LEKTEYTPLDFARMFDDLDIWGFLYTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHK 236 +N+DG G ++E K + + P+IASGG G++E + + V G + ++ Sbjct: 172 VNRDGAMVGPNIEGTKYLAQNLKHPVIASGGVGSVEDLKKLYDLKKYGVYGVVVGKALYE 231 Query: 237 QIINIGELKA 246 I + +L+ Sbjct: 232 GKIKLEQLED 241 >UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=31 Tax=cellular organisms RepID=HIS4_CHRSD Length = 249 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 111/252 (44%), Gaps = 17/252 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++DGQ V+ Q R + D V +A R+ E GA L D+ + +G+ V+ Sbjct: 3 VIPAIDLKDGQCVRLKQGRMDDSTTYGDDPVAMAARWVETGARRLHLVDLNGAFEGKPVN 62 Query: 63 KSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+ +A D+P + GGI++ E L G + I + A+ +P + + RF Sbjct: 63 AEAVTAIARAYPDLPIQIGGGIRTAETIEAYLEAGVSYVIIGTQAVKEPAFVGEMCRRFP 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 ++VG+D + Y + V+ + +D + G IV + + Sbjct: 123 G-HVIVGLDAR----------DGYVATDGWAEVSTLKAVDLAKRFADDGVSSIVYTDIAR 171 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR--DADVDGALAASVFHKQII 239 DG+ G ++ ++ +P+IASGG + DA + GA+ ++ + Sbjct: 172 DGMMQGVNIAATAELAREGGLPVIASGGVTHLGDIEALLEVADAGILGAITGRAIYEGKL 231 Query: 240 NIGELKAYLATQ 251 ++ E + Q Sbjct: 232 DVAEAQRLCDAQ 243 >UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MJ01_RHOM4 Length = 266 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 55/240 (22%), Positives = 107/240 (44%), Gaps = 17/240 (7%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+R G+ V+ Q R D V +A + + A L D+ A+ G+ + Sbjct: 4 VIPAIDIRGGRCVRLYQGSYERETVYFDDPVKMACLWRVQNARVLHVVDLDAAR-GQGHN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + +DIP V GG+++LED +L G ++ + + A+ +P L++ R+G Sbjct: 63 REVIGAICRTVDIPIQVGGGVRTLEDIEALLQVGVYRVVLGTAAVREPELVSEAIARYGC 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +VVGID A G+ V + T T + ++ ++++RG V +++D Sbjct: 123 SRVVVGID----ARDGEVRVQGW------TEGTGVDAVELALDMERRGVRRFVYTDISRD 172 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQII 239 G G ++E + + + + ASGG + VD + ++ Sbjct: 173 GTLEGPNVEMYRTLGLHLKKARITASGGVSGYRDLMRLQELEPYRVDSVIIGRALYENRF 232 >UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Prochlorococcus marinus str. MIT 9313 RepID=HIS62_PROMM Length = 261 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 82/265 (30%), Positives = 137/265 (51%), Gaps = 14/265 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKG--------VQFRNHEIIGDIVPLAKRYAEEGADELVFYDI 52 ML KR+IP L +G QF + IGD V AK Y + ADELV D+ Sbjct: 1 MLKKRLIPKLQFSIKPSYRGPKPVLVITRQFDSKRAIGDPVSQAKIYEAQLADELVLVDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 +SD + +S ++E + P V GGI S E ++L GADK+ +NS A+ +P L Sbjct: 61 EGTSDSWPILLDTLSNMSESLATPLSVGGGITSFEQVQQLLDRGADKVVLNSGAVNNPQL 120 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I +A+ +G QC+V+ ID +++ + + + + T W W + RGAG Sbjct: 121 IDLVANSYGSQCVVISIDIRKESDLSR-----HVYIDGGSTATDWSLFSWANDCASRGAG 175 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 E+++ ++ DG G DL+ ++++R ++PLIASGG G +HF+ + A + Sbjct: 176 ELLITSIDNDGTGTGLDLDSIRQLRYEVNLPLIASGGCGLAQHFVAG-YEVGASAVAAGT 234 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 F ++ N + ++++ G+ IR+ Sbjct: 235 FFSQRDQNPMQCRSHIRNAGLPIRL 259 >UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Aquificales RepID=HIS4_SULSY Length = 239 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 121/248 (48%), Gaps = 16/248 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDG 58 L + IIP +D++ G+VV+ + F ++ + + +AK + + GA+ + D+ + +G Sbjct: 3 LKEFIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + + ++IP GG++S E +L G +++ I S A +P ++ + Sbjct: 63 LPKNIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIVE 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 F ++VGID A+ GK + + T T+ L++ ++ + Sbjct: 123 SFPN-KVIVGID----AKDGKVAIKGW------TEKTEVSPLEFAKKYDDLDIFGFLFTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF--RDADVDGALAASVFHK 236 +++DG G ++E ++ + P+IASGG G++E ++ + R+ + G + ++ Sbjct: 172 VSRDGSMIGANVEATVELAKNLKHPVIASGGVGSLEDVIKLYEKREFGIFGVVVGKAIYE 231 Query: 237 QIINIGEL 244 I++ E+ Sbjct: 232 GKIDLKEI 239 >UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DY29_METI4 Length = 248 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 119/247 (48%), Gaps = 13/247 (5%) Query: 3 AKRIIPCLDVRDGQVVKGVQFR--NHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGR 59 ++ +D+ GQVV+ Q + + G D V A + +GAD L D+ + G Sbjct: 8 TMKMYAAIDLFKGQVVRLRQGKLEEMTVYGSDPVKTALFWQSQGADGLHIVDLEGAFSGT 67 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + ++A + IP GG++++E K L GA ++ I S + DP + L+++ Sbjct: 68 PRHLDLLEKIAYAVTIPIQFGGGLRTVEQVLKALEGGAQRVVIGSKLVTDPGFLQELSEK 127 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G + IV +DT + G+ + + + + + ++++ V+++GAG ++ + Sbjct: 128 IGPEKIVAALDT----QNGEIQIEGWK------KSSGYSLENFIKWVEQKGAGFLLYTNI 177 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG G D+ +KV E+ +P+ ASGG G + E + + GA+ ++ I Sbjct: 178 QTDGTLKGADVRGTQKVVEMSRLPVFASGGIGCTKDVEELLKLKGLYGAILGRSLYEGKI 237 Query: 240 NIGELKA 246 ++ E+K Sbjct: 238 SLSEIKK 244 >UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_DESHD Length = 250 Score = 240 bits (613), Expect = 4e-62, Method: Composition-based stats. Identities = 56/250 (22%), Positives = 128/250 (51%), Gaps = 18/250 (7%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDG 58 + R+ P +D+++G+ V+ +Q R + + G+ V +A+++ E+GAD L D+ + G Sbjct: 1 MRMRLFPAIDLKEGKAVRLLQGRMEDATVYGEQPVEVARKFKEQGADSLHVVDLDGAFAG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + V+ + + ++ + + V GGI++LE ++L G +++ + + A+ +P L+ + Sbjct: 61 KPVNDAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQ 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 RF + +V+GID A+ G V + T+ + LD ++K G +V Sbjct: 121 RF-EEAVVIGID----AKDGLVAVQGW------AEKTEIKALDLALRMKKVGVKHLVFTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD----VDGALAASVF 234 +++DG+ G +++ ++ + + ++ASGG +E +A+ ++GA+ Sbjct: 170 ISRDGMLQGPNIQSTVELARLSGLQVVASGGVSRLEDLRLLQEEANRGVSLEGAIVGKAL 229 Query: 235 HKQIINIGEL 244 + ++ E Sbjct: 230 YAGAFSLAEA 239 >UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria RepID=B4SDB6_PELPB Length = 256 Score = 239 bits (611), Expect = 6e-62, Method: Composition-based stats. Identities = 83/256 (32%), Positives = 134/256 (52%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M R+I LD++ ++KG+ +IG A RY ++G DEL++ D AS R Sbjct: 1 MRNIRLIARLDIKGPNLIKGIHLEGLRVIGSPNEYALRYYQQGVDELIYMDCVASLYDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + A+ I +P V GGI+S+EDA +IL GADK+++N+ A+A+P LI ++ RF Sbjct: 61 HLGDIIRSAAKDIFVPMTVGGGIRSVEDATQILRSGADKVAVNTAAVANPKLINEISRRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ I+ + ++ V G E T + + WV++ GAGE++L ++ Sbjct: 121 GSQCMVLSIEAKEVGKD-RWEVYTDNGRER----TGLDVIAWVKKGVAMGAGEVLLTSVD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G R G+D +K V +P+IASGG G E + D A + H Sbjct: 176 REGTRKGFDTALVKAVTAEVSIPVIASGGMGKPEDLVGVVSVGGADAVAMADILHYNRAG 235 Query: 241 IGELKAYLATQGVEIR 256 IGE++ G+ +R Sbjct: 236 IGEIRNVAKETGMGVR 251 >UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_FRAP2 Length = 241 Score = 239 bits (611), Expect = 6e-62, Method: Composition-based stats. Identities = 47/247 (19%), Positives = 104/247 (42%), Gaps = 11/247 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+ +G+ V+ + + + +AK Y + GA+ + D+ + G+ Sbjct: 1 MNIFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQT 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ E ++ V GG+K E K+L G D++ I S A+ D L + +++ Sbjct: 61 CQFETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IV+ +D + + + + + +Q G ++ ++ Sbjct: 121 GAEKIVLALDVFIKNGVPYIATHGWQ------ESSTTTLDEILQTYLGDGLEYVLCTDIS 174 Query: 181 QDGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G + E + + V +ASGG G++E E ++ + G + ++ Sbjct: 175 RDGMLQGPNFELYRIYSSIYPDVQFMASGGVGSLEDL-EILKEQNTYGVIIGKALYENKF 233 Query: 240 NIGELKA 246 + E Sbjct: 234 TLQEALE 240 >UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=209 Tax=Bacteria RepID=HIS4_HERAR Length = 265 Score = 238 bits (608), Expect = 2e-61, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 120/261 (45%), Gaps = 29/261 (11%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 ML +IP +D++DG V+ Q + D +A+ + E+GA L D+ + Sbjct: 1 ML---LIPAIDLKDGHCVRLKQGDMDQATVFSEDPADMARHWLEQGARRLHLVDLNGAFA 57 Query: 58 GRVVDKSWVSRVAEVI----------DIPFCVAGGIKSLEDAAKILSFGADKISINSPAL 107 G+ ++ V + + + +IP + GGI+ L+ + L G I I + A+ Sbjct: 58 GKPKNEPAVKAILQAVREYAEKNGIEEIPVQLGGGIRDLDTIERYLDDGLSYIIIGTAAV 117 Query: 108 ADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQ 167 +P + F Q I+VG+D A+ GK + + ++++ E +D ++ + Sbjct: 118 KNPGFLHDACSAFPGQ-IIVGLD----AKDGKVATDGW------SKLSGHEVIDLAKKFE 166 Query: 168 KRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADV 225 G I+ + +DG+ G ++E K+ + +P+IASGG ++ L A ++ + Sbjct: 167 DYGCESIIYTDIGRDGMMGGVNIEATVKLAQSMTIPVIASGGVHNIKDVEALCAVQEEGI 226 Query: 226 DGALAASVFHKQIINIGELKA 246 +G + ++ +++ + Sbjct: 227 EGVICGRSIYEGTLDLRSAQD 247 >UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=23 Tax=Bacteria RepID=HIS4_THEEB Length = 257 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 55/244 (22%), Positives = 107/244 (43%), Gaps = 16/244 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ VQ ++ D + +A + GA L D+ A+ G + Sbjct: 3 VIPAIDLLDGKCVRLVQGNYDKVNVFHDDPLKVALYWQRLGAPRLHLVDLDAAKTGEPRN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ ++IP V GG++S + A + G ++ + + AL +P L+ LA + Sbjct: 63 YDLIGKIVASLEIPVQVGGGLRSRQAVADLFLQGVNRAILGTVALENPKLVASLAAEYPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VG+D + Y ++ D Q + G V + +D Sbjct: 123 -RIWVGLDAR----------DGYVATRGWLETSKILATDLAQNMAAMGVAGFVYTDIQRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHKQIIN 240 G G ++ L+++ V + P+IASGG ++ L F + GA+ + + ++ Sbjct: 172 GTLQGPNIPALRQLLAVTNRPVIASGGVSSLNDILSLFALTPHGLVGAIVGKALYTKAMD 231 Query: 241 IGEL 244 + E Sbjct: 232 LREA 235 >UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_LACLS Length = 246 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 46/255 (18%), Positives = 113/255 (44%), Gaps = 15/255 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+++G+ V+ + + + + +A+++ + GA L D+ + G+ Sbjct: 1 MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQT 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILS-FGADKISINSPALADPTLITRLADR 119 + V ++ + ++ + GGI++L+ + L G +++ + + A P + L + Sbjct: 61 RNLEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVK 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 +G+ IVVG+D + T L ++++++K G +++ + Sbjct: 121 YGLSRIVVGVDIR----------EGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDI 170 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG G + E ++ + + +I SGG A D+D G + +++ I Sbjct: 171 SKDGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRA-ADSDFYGIIVGKAYYEGKI 229 Query: 240 NIGELKAYLATQGVE 254 N+ + + + Sbjct: 230 NLEKEFNHANKKNYP 244 >UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Bacillales RepID=HIS4_BACLD Length = 245 Score = 237 bits (605), Expect = 3e-61, Method: Composition-based stats. Identities = 54/256 (21%), Positives = 113/256 (44%), Gaps = 16/256 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSD 57 M + P +D+R+G+ V+ +Q + I G + +A R+AEEGA + D+ + + Sbjct: 1 MSEFTVYPAIDIRNGKCVRLIQGDYEKETIYGHSPLEMASRFAEEGASWIHLVDLDGARE 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ V+ V +A+ +D+ V GGI++ +D LS G +++ + S A+++ + ++ Sbjct: 61 GKKVNGGHVISIADKLDVKVQVGGGIRTEKDVYDYLSQGVERVILGSSAVSNTEFVKKML 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +G I +G+D + + E + + +E+ GA + Sbjct: 121 KAYGG-HIAIGLDAR----------DGFVSTEGWLETSSVRAEELGRELANEGAEVFIFT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFH 235 + DG+ +G ++ ++ +IASGG ++ A V GA+ + Sbjct: 170 DIATDGMLSGPNINSTVELARATGKQVIASGGVSSLADLEALASRASEGVSGAIVGKALY 229 Query: 236 KQIINIGELKAYLATQ 251 + E +A + Sbjct: 230 TNQFTVAEALERVAAK 245 >UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=6 Tax=Euryarchaeota RepID=D2RTG3_9EURY Length = 244 Score = 237 bits (605), Expect = 3e-61, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 126/246 (51%), Gaps = 14/246 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFRN--HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++IP +D++DG+VV+ VQ + GD V A+R+ +EGA+ L D+ + +G+ + Sbjct: 8 QVIPAVDMQDGEVVQLVQGERGTEKTYGDPVDAARRWLDEGAEALHLVDLDGAFEGQRAN 67 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V E +D+P + GGI++ +DA +L G D++ + + A+ +P ++ +++R Sbjct: 68 GDAIDEVLETVDVPTQLGGGIRTADDAVDLLERGVDRVILGTAAVENPDIVAEISERHP- 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +VV +D A+ G+ V + T +D + + GA I+ ++ + Sbjct: 127 DSVVVSLD----AKDGEVVVEGW------TEGAGISPVDAAERYAELGAAAILFTNVDVE 176 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G E ++++ E VP+IASGG T+E + A DA + S ++ + Sbjct: 177 GKLEGVAAEPVRELVEATDVPVIASGGVATLED-VRALEDAGAAAVVVGSALYEGKFTLA 235 Query: 243 ELKAYL 248 E ++ + Sbjct: 236 EAQSAI 241 >UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BNI2_9BACT Length = 248 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 77/256 (30%), Positives = 130/256 (50%), Gaps = 9/256 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML RIIP L +VK F+N ++G+ V A+ + G DEL+F DI A+ R Sbjct: 1 MLKNRIIPILTFNGLGLVKTKGFKNPRMVGNPVQTARVFNSRGVDELIFLDIYATKQSRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ S V V + +P + GGI++++ +L GADK+ I S AL D + + F Sbjct: 61 INLSLVKEVIKECYMPVSIGGGIQTIDQINDLLKIGADKVVIKSKALTDKKFLKEAINFF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI + +D + Y + G + +++ E+ AGE+++N +N Sbjct: 121 GSQCICISVDVLFV--NNNYLIYNDLGLK-------ISLEEFITEMSLINAGELLVNSVN 171 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV NG+D++ + KV ++ +P+IA+GG G EH+ F ++ ++S+FH Sbjct: 172 NDGVMNGFDIDLINKVEQMTTIPVIAAGGGGEPEHYSTLFNKTKINAVASSSIFHFTQYT 231 Query: 241 IGELKAYLATQGVEIR 256 ++K L +R Sbjct: 232 PLDIKNELKKFNFPVR 247 >UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF74_THET1 Length = 243 Score = 236 bits (602), Expect = 8e-61, Method: Composition-based stats. Identities = 57/245 (23%), Positives = 105/245 (42%), Gaps = 15/245 (6%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ +GQ+V+ Q R D V +A+++ GA L D+ + G V+ Sbjct: 3 VIPAIDILEGQLVRLTQGDYSRKKVYSYDPVVVARKWKAIGAQWLHVVDLDGARQGHPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V V GG+++LED I+ GA +I + + A+ DP + + ++ Sbjct: 63 VDVIKSVIMEFGPQVQVGGGLRTLEDIQSIVELGASRIVLGTSAVKDPEFLREVCAKYP- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +V +DT N + T+ + + L+ + V+ G G I+ + D Sbjct: 122 DMVVAALDTR----------NGVVAIDGWTKSSGLDVLEVAKLVEDAGVGYILFTAIETD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G D+ ++++ VP+IASGG E E A V + ++ + Sbjct: 172 GTMTGPDIAAVQRLMSHVSVPVIASGGISEPEDLEE-LSKAGVYAVIVGKALYEGRLPEE 230 Query: 243 ELKAY 247 + Y Sbjct: 231 VITTY 235 >UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=root RepID=HIS4_PELUB Length = 239 Score = 236 bits (602), Expect = 8e-61, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 108/248 (43%), Gaps = 14/248 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D++D + V+ ++ E V A +Y + G L D+ + G Sbjct: 1 MKIFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGET 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + D+ V GG++S++ K ++ G +K+ + S A+ + + +F Sbjct: 61 VNLDIIKEIVHKFDLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I +G+D + Y + TLD+++EV GA ++ +N Sbjct: 121 PN-KIALGLDAK----------DGYLSVSGWKENSNQLTLDFLKEVNDYGASRLIYTDIN 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + + E+ V V + P+I SGG +++ +A +++G + + I Sbjct: 170 RDGTKESPNFEETTNVANVSNCPVIISGGVSSIDDIKKAKGLKNIEGIIVGKAIYDGDIK 229 Query: 241 IGELKAYL 248 + EL L Sbjct: 230 LEELVKEL 237 >UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Chlorobiaceae RepID=HIS4_CHLT3 Length = 262 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 59/244 (24%), Positives = 117/244 (47%), Gaps = 18/244 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 ML IIP +D++ G+ V+ + + + + +A + ++ A + D+ A+ Sbjct: 1 ML---IIPAIDIKGGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALT 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ + + ++ + +DIP + GGI++ EDAA+ L G ++ I S A+ +P+L+++L Sbjct: 58 GKPENFDKIKQIVDTLDIPIEIGGGIRTAEDAARYLDIGVYRVVIGSAAVKNPSLVSQLI 117 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +++G + IVVGID AE G ++ + T +Q + + E++ RG I+ Sbjct: 118 EKYGPRKIVVGID----AEDGIAKISGW------TESSQKKDYELALEMKDRGVERIIYT 167 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFH 235 + +DG G E K E + + ASGG + + VD + + Sbjct: 168 DITRDGTLEGVGYETTKAFAEKAQMRITASGGVFGKQDLSKLCKLEHLGVDSVIIGKALY 227 Query: 236 KQII 239 ++ Sbjct: 228 EERF 231 Score = 42.0 bits (98), Expect = 0.022, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 38/110 (34%), Gaps = 6/110 (5%) Query: 33 VPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKI 92 LA + G + +++ DIT V AE + +GG+ +D +K+ Sbjct: 150 YELALEMKDRGVERIIYTDITRDGTLEGVGYETTKAFAEKAQMRITASGGVFGKQDLSKL 209 Query: 93 LSF---GADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGK 139 G D + I + +L F + +DT + K Sbjct: 210 CKLEHLGVDSVIIGKALYEERFPCQKLWHLFEES---ISLDTNFSTAEQK 256 >UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW7_9FIRM Length = 243 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 120/252 (47%), Gaps = 16/252 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+R G+ V+ ++ F + D +AK++ +GA L D+ + GR + Sbjct: 3 IFPAIDIRGGKCVRLLKGDFAKETVFSDKPEEMAKKWQTQGAQFLHLVDLDGALAGRPQN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + +DIP + GGI++LE ++L+ G ++ + S A+ DP L+ ++G Sbjct: 63 LATVKAILAAVDIPVELGGGIRTLESIDEVLALGVRRVILGSVAVRDPELVKTACAKYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IVVGID A+ G V+ + E +E++K G I+ +++D Sbjct: 122 DRIVVGID----AKDGIVAVDGWGV------SGDVEATALAKEMKKAGVKTIIYTDISRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIIN 240 G G ++E K+ V ++ASGG ++ L+ + A ++G + + ++ Sbjct: 172 GTLAGVNVEATAKLARESGVAVVASGGVKSIADIEALKPYEKAGIEGVIVGKSIYMGTLD 231 Query: 241 IGELKAYLATQG 252 + E A +G Sbjct: 232 LAEAIEIAAKEG 243 >UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=17 Tax=Epsilonproteobacteria RepID=HIS4_CAMHC Length = 236 Score = 233 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 103/244 (42%), Gaps = 16/244 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRN---HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+++G V+ + LA+++A+ GA L D+ + G Sbjct: 1 MEILPAIDLKNGFAVRLKKGEMNSAKIYSDKPWELAEKFADLGAKWLHIVDLDGAFAGEA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ + ++ V GGI+ E + G + + S AL +P + ++A ++ Sbjct: 61 KNAKTIEKIVKSTNLKIEVGGGIRDEERIKFYKNSGVSRFILGSAALKNPEFVKQMAKKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I VGID N + E V+ + + + G I+ ++ Sbjct: 121 ---KIAVGIDAK----------NGFVATEGWAEVSNIKACELAKIYADAGVEAIICTDIS 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ +G +++ +++ + + IASGG + + + G + +++ I+ Sbjct: 168 KDGMLSGVNVKFSEEIAKSSGIKTIASGGVKDLSDIKALKQSGKIYGVIVGKAYYEGSID 227 Query: 241 IGEL 244 + E Sbjct: 228 LKEA 231 >UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=97 Tax=Gammaproteobacteria RepID=HIS4_YERP3 Length = 245 Score = 233 bits (594), Expect = 7e-60, Method: Composition-based stats. Identities = 56/245 (22%), Positives = 108/245 (44%), Gaps = 10/245 (4%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD+ +G+VV+ Q G+ +P + Y ++GA L D+T + D Sbjct: 2 IIPALDLIEGKVVRLHQGDYGQQRDYGNHPLPRLQDYQQQGAQVLHLVDLTGAKDPAARQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +D+P V GGI++ +D +L GA ++ + S A+ P ++ + +R+G Sbjct: 62 IPLLRELLAGVDVPVQVGGGIRNEQDVVALLEAGAARVVVGSTAVKQPEMVQQWFERYGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+ +D + K + + V++ G ++ +++D Sbjct: 122 EAIVLALDVRINEAGCK-----HVAISGWQENSDATLEQIVEQYLPYGLKHVLCTDISRD 176 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G +G ++E ++V + V ASGG G ++ R + V G + N+ Sbjct: 177 GTLSGSNVELYQEVCQRYPQVAFQASGGIGCLDDIAR-LRGSGVQGVIVGRALLDGKFNV 235 Query: 242 GELKA 246 E A Sbjct: 236 KEAIA 240 >UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Clostridia RepID=HIS4_SYNWW Length = 244 Score = 232 bits (593), Expect = 9e-60, Method: Composition-based stats. Identities = 65/251 (25%), Positives = 123/251 (49%), Gaps = 15/251 (5%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DGQ V+ VQ R N + D +A+ + E+GA L D+ + G + Sbjct: 3 IYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSPQN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A IDI F V GG++ L D K+L+ GA ++ I + A++ P I L D+FG Sbjct: 63 LKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKFGP 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+G+D A+ G V + + +D+ +++ G + +++D Sbjct: 123 ERIVLGLD----AKEGMVAVEGWVST------SSVSAIDFGLQMKALGIQTAIYTDVSRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIIN 240 G+ G +L +K++ + +IASGG ++++ L+ + V GA+ + I Sbjct: 173 GLLQGPNLAAIKEMASSTGLDIIASGGVSSLDNIRALKELENDGVSGAIIGKALYDGKIG 232 Query: 241 IGELKAYLATQ 251 + + ++ Sbjct: 233 LVDALREAESK 243 >UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase subunit hisF3 n=18 Tax=cellular organisms RepID=HIS63_VIBVY Length = 260 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 86/237 (36%), Positives = 136/237 (57%), Gaps = 4/237 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L +R+ +VK V+F+ + +GD + K + E+ ADEL DI AS G Sbjct: 6 MLRSRVIPVLLMREKGLVKTVKFKEGKYVGDPLNAVKIFNEQEADELTLLDIDASRLGHE 65 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + R+A +P C GGIK++E A +IL G +K+S++S +P +IT+LA+R Sbjct: 66 PDYVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERV 125 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D K+ G + ++ +T+++V+++Q GAGEIVLN ++ Sbjct: 126 GRQSIVVCLDVKKRLFGSKFDCFTINGTKKQS----VDTIEFVKQIQTLGAGEIVLNFID 181 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 DGV GYDL+ + K + + VPL GGAG ++ + + + GA A S+F + Sbjct: 182 NDGVMKGYDLDAVSKFKALVKVPLTVVGGAGCVDDIAKLVQQEKLVGAAAGSLFVFK 238 >UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9Y4_9FIRM Length = 245 Score = 231 bits (591), Expect = 2e-59, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 108/249 (43%), Gaps = 16/249 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 M A + P +D+R G V+ + + D +A+R+AE GA + D+ + Sbjct: 1 MEAMNLYPAIDLRGGMCVRLEKGNFSKETVYSKDPGAMARRFAEAGARTIHVVDLDGALA 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ + S + + I V GGI++ E +LS G ++ + S A+ DP L+ R Sbjct: 61 GKSENLSAIKAILREGGISIEVGGGIRTYEQIEGLLSLGVSQVILGSAAIYDPQLVERAN 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 F IVVGID N Y + + + + V G I+ Sbjct: 121 RDFPY-KIVVGIDAK----------NGYAAADGWEKDSNLTAEALARRVAAAGTERIIFT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFH 235 +++DG+ NG ++E + + C VP+ ASGG ++E L+A ++G + + Sbjct: 170 DISRDGMMNGSNIEATAALYQACGVPITASGGVSSLEDIRRLKARETDGIEGCIIGKALY 229 Query: 236 KQIINIGEL 244 ++ + Sbjct: 230 AGAFSLSDA 238 >UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) n=8 Tax=Saccharomycetales RepID=C4R8P0_PICPG Length = 561 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 90/313 (28%), Positives = 141/313 (45%), Gaps = 58/313 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFR--------NHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ + +G V +A++Y ++GADE+ Sbjct: 246 LTRRIIACLDVRTNDSGDLVVTKGDQYDVREKSESGDVRNLGKPVEMAEKYYQQGADEVT 305 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKSLED-----------AAKILS 94 F +IT+ + + D + R AE + +P V GGIK + D A Sbjct: 306 FLNITSFRNSPIKDAPMLEVLKRAAETVFVPLTVGGGIKDVVDPDGTKVPALKVATLYFR 365 Query: 95 FGADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGIDTWY-------- 133 GADK+SI + A+ T I ++ +GVQ +V+ +D Sbjct: 366 AGADKVSIGTDAVLAAEEFYRNNEKGTGLTPIETISASYGVQAVVISVDPKRFYVADPSK 425 Query: 134 ----------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 G+ + + V + +K GAGEI+ N +++DG Sbjct: 426 TPYKTIKTKFPGPNGENYCYYKVTSQGGRNVHDLGAWELCYACEKLGAGEILCNCIDKDG 485 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +GYDLE + ++ +P+IAS GAG HF E FR + D AL A +FH+ + E Sbjct: 486 SNSGYDLELIDYIKSATKLPVIASSGAGNPSHFEEVFRKTETDAALGAGMFHRGEYTVKE 545 Query: 244 LKAYLATQGVEIR 256 +K +L +G+ +R Sbjct: 546 VKDFLTKRGLLVR 558 >UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrio RepID=HIS4_DESVH Length = 249 Score = 231 bits (589), Expect = 2e-59, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 111/252 (44%), Gaps = 17/252 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+ +G V+ + R D V A+ + E+G L D+ + G+ V+ Sbjct: 3 VFPAIDLMNGVCVRLRRGRADDETVFSSDPVATARHWQEQGGRWLHVVDLDGAFSGQPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + +DIP + GGI+ A L G +++ I + AL +P L F Sbjct: 63 APLIRSICDALDIPVQLGGGIRDAATAKAYLEAGVERLIIGTIALEEPDAYAALCAEFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I DAE GK + D + + + + + G I+ +++D Sbjct: 123 R-----IGVSLDAEGGKLKTKGWVAD------SGLTVDEVLPRLLEAGTAFIIYTDIDRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF---RDADVDGALAASVFHKQII 239 G++ G +L L+ + + VP+IA+GG T+E + R ++ GA++ ++ + Sbjct: 172 GMQTGVNLPALEHLAKASTVPVIAAGGVATLEDVKALYPLSRTTNLQGAVSGRAIYEGTL 231 Query: 240 NIGELKAYLATQ 251 ++ ++ Q Sbjct: 232 DLRTAMDWIRQQ 243 >UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Listeria grayi DSM 20601 RepID=C2BYH3_LISGR Length = 240 Score = 230 bits (587), Expect = 4e-59, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 114/246 (46%), Gaps = 15/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D+++G+ V+ Q + D + A ++A GA L D+ + G+ Sbjct: 1 MQIFPAIDIKNGKCVRLYQGDFAKETMMNADPIDQAAKFAAAGATFLHIVDLDGAVSGKP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + R+ + + IP V GGI+++ L GA+++ I S AL+DP + ++ Sbjct: 61 TNIALIQRLQQQVKIPIQVGGGIRTMTQVDTYLRAGAERVIIGSAALSDPDFVKAAVTKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G I++GID N + E +++ + + E+ K G I+ ++ Sbjct: 121 G-DKIIIGIDAK----------NGFVATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G + E+L+ +++ + +IASGG + E GA+A ++ I Sbjct: 170 KDGTLAGPNFEELRAIQKSARIAVIASGGVSSKADL-EQLAAEGFYGAIAGKALYEGKIT 228 Query: 241 IGELKA 246 + ++ Sbjct: 229 MADVLE 234 >UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H029_9FIRM Length = 250 Score = 230 bits (587), Expect = 4e-59, Method: Composition-based stats. Identities = 104/255 (40%), Positives = 154/255 (60%), Gaps = 6/255 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + K I+PC+D+R G+VVKG++F + + D V LAK Y GAD LVFYDI AS + + + Sbjct: 1 MKKLIMPCMDIRHGKVVKGIKFEGVKDVADPVELAKYYDATGADILVFYDIAASVEDKQI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V V D+P GG+K++ED I+ GAD +SIN+ A+ +P L+ A++ G Sbjct: 61 YEGLFKSVRAVSDLPLVAGGGLKTIEDVDNIIKLGADMVSINTGAIDNPDLLNEAAEKIG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +++ +D G+YHV + G T + L+W+ E RGAG +VLN ++ Sbjct: 121 SENVILSVDAKKV--NGEYHVFRNAGMMD----TGLDALEWISEGYDRGAGILVLNSIDT 174 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DGV+ GYD+E LK EV ++ASGGAG M+ F EA V+ ALAASVFH + I I Sbjct: 175 DGVKAGYDIEMLKAAGEVTDAKIVASGGAGKMQDFKEALMLPKVEVALAASVFHYKEIVI 234 Query: 242 GELKAYLATQGVEIR 256 +LK YL +G+++ Sbjct: 235 DDLKEYLRKEGIDVN 249 >UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_CLOK1 Length = 238 Score = 230 bits (587), Expect = 4e-59, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 117/245 (47%), Gaps = 15/245 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D++ G+ V+ + + D A ++ EGA L D+ + G + Sbjct: 3 ILPAIDLKGGKCVRLYKGDMNSQEVVARDPFETALKFKSEGAQYLHMVDLDGALKGSGEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S++ + +D+P V GGI+++E K + G ++ + + AL + L+ + + + Sbjct: 63 LDIISKIVKNVDVPIEVGGGIRNIETIDKFIKLGVSRVILGTAALKNKELVIKAVENY-D 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I VGID + + T +++ +D+ +E++K G ++ +++D Sbjct: 122 EKIAVGIDAK----------DGVPAADGWTTLSKTNYIDFGKEMEKIGVQTLIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G +LEQL K++ +IASGG +E ++ + +V GA+ + + +++ Sbjct: 172 GTLEGTNLEQLLKLKNSVKCNVIASGGIKDIEDI-KSLKKENVYGAIVGKAIYAKTLSLK 230 Query: 243 ELKAY 247 + Sbjct: 231 KAIEI 235 >UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Thaumarchaeota RepID=HIS4_NITMS Length = 236 Score = 229 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 64/246 (26%), Positives = 120/246 (48%), Gaps = 16/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IIP +D+ DGQVV+ + + D V +AK++ + GAD L D+ A+ G Sbjct: 1 MKIIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDLDATI-GTG 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++++ + IP VAGG+++ E + +SF ++++ I + A D ++ R+A ++ Sbjct: 60 SNLDLIEKISKELSIPVEVAGGLRNEEIIDRAISF-SNRVVIGTMAFKDKEMLQRIAKKY 118 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 IV+ +D H++ + T+ LD + E G E +L ++ Sbjct: 119 DFSKIVISVD----------HIDGFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVS 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G DLE L+K V + +IASGG ++ + R + + ++ I+ Sbjct: 169 KDGTLEGPDLEYLEKACAVQNANVIASGGISNIDDVSDVQRK-NAFAVILGKALYENKIS 227 Query: 241 IGELKA 246 I E K Sbjct: 228 IEEAKQ 233 >UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6X1_NATTJ Length = 246 Score = 229 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 121/257 (47%), Gaps = 19/257 (7%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +IP +D+ +G+ V+ + + +A+ + E+GA L D+ + G Sbjct: 1 MSLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 V + + + ++A + IP V GGI+S+E ++++ G D++ + + A D + + Sbjct: 61 SVKNSTIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 F + I+VG+D + GK + V+ +T D++ E+ + G ++L Sbjct: 121 LFH-KNIIVGVDI----KGGKVATEGWV------NVSDTKTYDYLSELTELGVPRVILTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDA---DVDGALAASV 233 +++DG G +LE K++ + L+ SGG ++E ++ ++ ++ G + Sbjct: 170 ISKDGKLQGPNLELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKA 229 Query: 234 FHKQIINIGELKAYLAT 250 ++ I++ + Sbjct: 230 LYEGKIDLQGALETIRK 246 >UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=92 Tax=Proteobacteria RepID=HIS4_ACTP2 Length = 250 Score = 229 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 107/245 (43%), Gaps = 10/245 (4%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD+ DG VV+ Q + + + Y +GA++L D+T + Sbjct: 7 IIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFANYLAQGAEQLHLVDLTGAKYPAKRQ 66 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + V GGI++ +D A +L+ GA+++ I S A+ D ++ +++G Sbjct: 67 TALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYGA 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V+ +D DA K + + +++ Q G ++ +++D Sbjct: 127 EKFVLALDVNIDASGQKI-----IAISGWQEASGVSLEELIEDYQVVGLQHVLCTDISRD 181 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G ++ +++ + + +SGG G+++ +A + V G + + N+ Sbjct: 182 GTLAGSNVNLYREICAKYPKIHFQSSGGIGSLDDI-KALKGTGVSGVIVGRALLEGKFNV 240 Query: 242 GELKA 246 E Sbjct: 241 AEAIE 245 >UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_YEAST Length = 552 Score = 229 bits (585), Expect = 8e-59, Method: Composition-based stats. Identities = 88/314 (28%), Positives = 141/314 (44%), Gaps = 58/314 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQF--------RNHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ + +G V LA++Y ++GADE+ Sbjct: 236 LTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVT 295 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKSLEDAA-----------KILS 94 F +IT+ D + D + + A+ + +P V GGIK + D Sbjct: 296 FLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFR 355 Query: 95 FGADKISINSPALADPTL-------------ITRLADRFGVQCIVVGIDTW--------- 132 GADK+SI + A+ I ++ +G Q +V+ +D Sbjct: 356 SGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQAD 415 Query: 133 ---------YDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 Y G+ + + + + + GAGEI+LN +++DG Sbjct: 416 TKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDG 475 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +GYDLE ++ V++ +P+IAS GAG EHF EAF D L A +FH+ + + Sbjct: 476 SNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVND 535 Query: 244 LKAYLATQGVEIRI 257 +K YL G+++R+ Sbjct: 536 VKEYLLEHGLKVRM 549 >UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Alteromonadales RepID=HIS4_COLP3 Length = 261 Score = 229 bits (584), Expect = 9e-59, Method: Composition-based stats. Identities = 54/244 (22%), Positives = 101/244 (41%), Gaps = 10/244 (4%) Query: 7 IPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IP +D+ G+VV+ Q + + YAE GA + F D+ + D Sbjct: 3 IPAIDLIGGEVVRLYQGDYAQKTNYQYTVQDRQQAYAESGATVMHFVDLDGAKDSTKRQL 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + V + V GG++ +D ++L+ GAD++ I S A+ P L+T+ +G + Sbjct: 63 KTLKTVVNHPSMIIQVGGGVRCEDDVKQLLALGADRVVIGSLAIKQPELVTQWVKTYGCE 122 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 IV+ +D DA+ K + D + + Q G ++ +++DG Sbjct: 123 KIVLALDIKIDAQGNKT-----LPTHGWIEDSGVNLEDLLAQYQDAGIKHVLCTDISKDG 177 Query: 184 VRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G +++ +V + + ASGG G++ +A V G + + + Sbjct: 178 TLTGTNVDLYSEVCAKYPDIDWQASGGIGSLADI-KALIPTGVSGVILGRSLLEGKFTLE 236 Query: 243 ELKA 246 E A Sbjct: 237 EAIA 240 >UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Proteobacteria RepID=HIS4_NITSB Length = 238 Score = 228 bits (583), Expect = 1e-58, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 107/250 (42%), Gaps = 16/250 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQF--RNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D++DG+ V+ + + +I D +AKR+ E G+ L D+ + G Sbjct: 1 MEILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ + + GGI+ E K + G +++ + S A+ +P + +A ++ Sbjct: 61 KNLEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I VGID ++ + E + + D +E K G I+ + Sbjct: 121 P---IAVGID----------AIDGFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVG 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G +++ + E + IASGG +E + V G + F++ ++ Sbjct: 168 KDGTLSGVNVDFTVSIAEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLD 227 Query: 241 IGELKAYLAT 250 + E + Sbjct: 228 LEEAFRLVQN 237 >UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CARHZ Length = 243 Score = 228 bits (583), Expect = 1e-58, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 103/251 (41%), Gaps = 16/251 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ +VV+ Q V LA +Y E GA + D+ + G + Sbjct: 3 LIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 ++ + + + IP V GGI+ +E +++ G ++ + + A+ +P L+ + Sbjct: 63 FEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEML-TLDR 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + VGID N + + + + LD +V++ G I+ + +D Sbjct: 122 DKVAVGIDAK----------NGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVFHKQIIN 240 G G + + K+ + +IASGG +E + + G +A + I+ Sbjct: 172 GSLTGPNFNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKID 231 Query: 241 IGELKAYLATQ 251 + E L + Sbjct: 232 LKEGIRILEGE 242 >UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Prochlorococcus marinus str. NATL1A RepID=A2C1S3_PROM1 Length = 248 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 71/247 (28%), Positives = 130/247 (52%), Gaps = 6/247 (2%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 RII LDV++ V+KG+ +GD LA Y ++G +E+VF D AS R Sbjct: 1 MRIIGRLDVKNNHVIKGIHLEGLRKVGDPQELAVEYYKQGIEEIVFMDAVASLYNRNNLF 60 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + E + +P + GG++SL+D +K L+ GADK+ IN+ + L +A ++G Q Sbjct: 61 HIIQKACEKVFVPIALGGGLRSLDDVSKALNAGADKVVINTALVNRIDLAKEIAQKYGSQ 120 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 C+V I+ + ++ + +V+ + T+ +DW ++++ G GEI+L ++Q+G Sbjct: 121 CLVGSIEAKRENDSWRVYVD------NGREPTKHNVVDWAIKLKEAGVGEILLTSIDQEG 174 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 G+D+E +K++ E P+IASGG G +H + + + A H + + Sbjct: 175 TSKGFDIELIKQINESIRCPIIASGGYGNKKHLADLLKIVEPSAIAIAGSLHYKKDTVSS 234 Query: 244 LKAYLAT 250 +K + + Sbjct: 235 IKQEINS 241 >UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C5E2I9_LACTC Length = 550 Score = 228 bits (581), Expect = 2e-58, Method: Composition-based stats. Identities = 90/314 (28%), Positives = 139/314 (44%), Gaps = 58/314 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFR--------NHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ N +G V LA++Y E+GADE+ Sbjct: 234 LTRRIIACLDVRTNDQGDLVVTKGDQYDVREKQEGGNVRNLGKPVELAQKYYEQGADEVT 293 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKSLEDAA-----------KILS 94 F +IT+ D + D + + A+ + +P V GGIK + D + Sbjct: 294 FLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTHIPALQVAALYFA 353 Query: 95 FGADKISINSPALADPTL-------------ITRLADRFGVQCIVVGIDTWYDAETGKYH 141 GADK+SI S A+ I ++ +G Q +V+ +D G Sbjct: 354 SGADKVSIGSDAVYAAEKYYELGERGDGASPIETISKSYGAQAVVISVDPKRVYVDGPES 413 Query: 142 VNQYTGD------------------ESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 V T + + + + + GAGE++LN +++DG Sbjct: 414 VKHKTFETKFPNEKGQTWCWYQCTIKGGRESRDMGVWELTRACEALGAGEVLLNCIDKDG 473 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +GYDLE + +E +P+IAS GAG +HF EAF D L A +FH+ + + Sbjct: 474 SNSGYDLELINHAKEAVKIPVIASSGAGEPKHFKEAFESTGADACLGAGMFHRGEYTVND 533 Query: 244 LKAYLATQGVEIRI 257 +K YL G ++R+ Sbjct: 534 VKQYLLDSGFKVRM 547 >UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=144 Tax=Bacteria RepID=HIS4_CORJK Length = 258 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 115/253 (45%), Gaps = 15/253 (5%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +DV DGQ V+ VQ G + A + GA+ + D+ A+ GR + Sbjct: 12 LLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAF-GRGSNF 70 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + V +D+ ++GGI+ E + LS G +++I + AL DP + R+G Sbjct: 71 ELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYG-D 129 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + +G+DT + +T D E + ++ + +G +V+ +++DG Sbjct: 130 KVAIGLDTREVDGEWRLRGRGWTSDGG-------ELWEVLERLDSQGVSRLVVTDVSRDG 182 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIINI 241 + NG +++ L++V P++ASGG +++ L A VD A+ + + Sbjct: 183 MLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFTL 242 Query: 242 GELKAYLATQGVE 254 E A QGV Sbjct: 243 EEALE--AAQGVA 253 >UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CALS8 Length = 237 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 57/242 (23%), Positives = 102/242 (42%), Gaps = 14/242 (5%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q R E D V AK + +EGA L D+ + G V+ Sbjct: 3 VIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+ E + GGI+ + L G D I + S +P + + RFG Sbjct: 63 FEVIKRIKESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRFGN 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + +D Y T+ + + ++K G +++ + D Sbjct: 123 ERFIASLDFE----------EGYVKLSGWQEATRISVEEGILHIKKLGFQKLIYTDIKTD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G++ E K +R + LI+SGG +M L+ +D VDG + + + + Sbjct: 173 GMLKGHNFEAAKYIRSLFDGFLISSGGISSMNDVLK-LKDIGVDGVIIGKALYTGHVKLN 231 Query: 243 EL 244 E+ Sbjct: 232 EI 233 Score = 41.6 bits (97), Expect = 0.026, Method: Composition-based stats. Identities = 22/114 (19%), Positives = 41/114 (35%), Gaps = 2/114 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 R I LD +G VK ++ I + + G +L++ DI + + Sbjct: 124 RFIASLDFEEGY-VKLSGWQEATRI-SVEEGILHIKKLGFQKLIYTDIKTDGMLKGHNFE 181 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + D +GGI S+ D K+ G D + I + + + Sbjct: 182 AAKYIRSLFDGFLISSGGISSMNDVLKLKDIGVDGVIIGKALYTGHVKLNEIIN 235 Score = 40.5 bits (94), Expect = 0.051, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 53/129 (41%), Gaps = 10/129 (7%) Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 ++ ID GK V GD SR + + + + +K GA + + ++ DG Sbjct: 3 VIPAIDII----DGK-CVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHV--VDLDGA 55 Query: 185 RNG--YDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 + G + E +K+++E + + GG + + + A +D + SV K + Sbjct: 56 KKGSPVNFEVIKRIKESTSLSVECGGGIRDKK-TINDYLLAGIDYIILGSVIFKNPEFVE 114 Query: 243 ELKAYLATQ 251 ++ + Sbjct: 115 DVLKRFGNE 123 >UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFDF6 Length = 236 Score = 226 bits (578), Expect = 5e-58, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 113/248 (45%), Gaps = 15/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 RI P +D+++GQ+V+ + + + D + + + +EGA L D+ + G + Sbjct: 1 MRIFPAIDIKNGQIVRLTEGKYDQVKVYSKDPEEVLEHFTKEGATALHIVDLDGAKSGTI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +++ + + + + GGI+ L+ G D++ + + A+ +P + + ++ Sbjct: 61 ENQNTIKTILKNRHFVTQLGGGIRDESTINHYLNMGVDRVILGTVAVENPKFVEEMVKKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q I VG+D + G+ N + + ++ + +++ + + G I+ ++ Sbjct: 121 -DQQIAVGVD----EKDGQVRANGWLVN------SKVDAIEFCKMLTAMGVATIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G D+ +++ + V +IASGG ++ E + V G + ++ I Sbjct: 170 KDGMMAGCDMASYRQLCKDRKVNIIASGGVTSIAEIKE-LKRIGVAGVIVGKAIYEGKIA 228 Query: 241 IGELKAYL 248 + E A Sbjct: 229 LREATAIC 236 >UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Firmicutes RepID=HIS4_CLOBA Length = 237 Score = 226 bits (577), Expect = 6e-58, Method: Composition-based stats. Identities = 57/245 (23%), Positives = 121/245 (49%), Gaps = 15/245 (6%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+ DGQ V+ Q + + DI +AK + GA+ + D+ + G V+ Sbjct: 3 ILPAIDIIDGQAVRLYQGDYNKKEVVANDIFNIAKEFECLGAEYIHLVDLDGAKSGYCVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++A+ +D+P V GGI++ E K++ G ++ + + A+ D L+ + + +G Sbjct: 63 EKIILKLAQTVDVPIEVGGGIRNFETIEKLIENGISRVILGTIAMEDEGLLKKAIECYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I VGID N Y ++ LD+ + ++ G I++ +++D Sbjct: 122 EKISVGIDCK----------NGYVYGRGWLAESKLNYLDFAKNMESLGVKSIIVTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G + + L K++++ ++ + ASGG +E+ E ++ D+ GA+ + +++ Sbjct: 172 GTLEGPNFDMLMKLKKLVNIDITASGGIRDIENIKE-LKNIDIYGAITGKAIYSGNLSLK 230 Query: 243 ELKAY 247 E Sbjct: 231 EAIDI 235 >UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=HIS4_UNCTG Length = 244 Score = 226 bits (576), Expect = 7e-58, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 119/248 (47%), Gaps = 16/248 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+R G V+ Q D V +AK + +GA L D+ + G ++ Sbjct: 3 IIPAVDIRQGNSVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTNIN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 K+ + + +DIP V GGI++++ ++ GA + + A +P ++ + R+G Sbjct: 63 KAIIKNICAAVDIPVEVGGGIRNMDKIKEVFDIGAAYAILGTVAFNNPEIVKKAITRYGS 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I+V +D A+ GK ++ + +T E + V ++++ G EI+ +++D Sbjct: 123 EKIIVAVD----AKDGKVAISGWK------DITPIEASELVNKLKEIGVQEILYTDISRD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR--DADVDGALAASVFHKQIIN 240 G+ G D LKK+ E + +IASGG T+++ ++ + V A+ S + Sbjct: 173 GMFTGPDFAGLKKLSES-GMRIIASGGVKTIDNLVKLKKYEKDGVFAAIVGSALYTDDFK 231 Query: 241 IGELKAYL 248 + + + Sbjct: 232 LEDAIEEI 239 Score = 41.2 bits (96), Expect = 0.032, Method: Composition-based stats. Identities = 21/120 (17%), Positives = 49/120 (40%), Gaps = 6/120 (5%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +++II +D +DG+V + + L + E G E+++ DI+ D Sbjct: 122 SEKIIVAVDAKDGKVA--ISGWKDITPIEASELVNKLKEIGVQEILYTDISRDGMFTGPD 179 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLED---AAKILSFGADKISINSPALADPTLITRLADR 119 + + +++E + +GG+K++++ K G + S D + + Sbjct: 180 FAGLKKLSES-GMRIIASGGVKTIDNLVKLKKYEKDGVFAAIVGSALYTDDFKLEDAIEE 238 >UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3165B Length = 246 Score = 224 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 57/249 (22%), Positives = 114/249 (45%), Gaps = 16/249 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+R G V+ Q D + A+ + E GA L D+ + DGR + Sbjct: 3 LYPAIDIRGGSAVRLRQGDFADETVYDADPLSAARAWVEGGARWLHVVDLDGARDGRPAN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+A + +P GG++S + GA+++ + + A AD + + +G Sbjct: 63 LEHLRRIAGELGVPVEFGGGLRSRASVDAAIEAGAERVILGTAAFADVDFLDDVVAAYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV +D GK + T+ E + +Q+RG ++V + + +D Sbjct: 122 ERVVVSVDV----RGGKVASAGWK------EQTEMEAAAVIDHLQRRGVRKLVYSNIERD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIIN 240 G+ G DL+++++V E I SGG G+++H L + R +++G + +++ Sbjct: 172 GMLTGPDLDEVRRVAESVRGSFIYSGGIGSLDHLAALASLRQVNLNGVIVGKALYERKFT 231 Query: 241 IGELKAYLA 249 +G+ L Sbjct: 232 VGDALTALK 240 >UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=35 Tax=cellular organisms RepID=HIS4_GRAFK Length = 241 Score = 224 bits (572), Expect = 2e-57, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 112/252 (44%), Gaps = 15/252 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 RIIP +D+ +G+ V+ + D + +AK + G + L D+ + + Sbjct: 1 MRIIPAIDIIEGKCVRLSKGDYATKKIYNEDPLEVAKSFEAHGIEYLHLVDLDGAKSSHI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + +A + GG+K+ +D GA +I+ S A+ + + +F Sbjct: 61 VNHKILETIANKTSLKIDFGGGLKTDKDLQIAFESGASQITGGSIAVKNSDVFQNWIQKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I++G D A+ K V+ + D + E + ++Q +++G ++ ++ Sbjct: 121 GNKKIILGAD----AKDRKIAVSGWLED------SNEEIIPFIQNYEEKGVKYVICTDIS 170 Query: 181 QDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G E K++ ++ LIASGG + + + +G + ++ I Sbjct: 171 KDGMLEGPSFELYKEILSETKNINLIASGGISEFDELPK-LAELGCEGVIIGKAIYENRI 229 Query: 240 NIGELKAYLATQ 251 ++ + + Y+ Q Sbjct: 230 SLKQFENYILNQ 241 >UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=HIS4_THERP Length = 244 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 56/241 (23%), Positives = 106/241 (43%), Gaps = 15/241 (6%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+R+G+ V+ + R D + +A+R+A GA L D+ + G+ V Sbjct: 3 VIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPVQ 62 Query: 63 KSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + RV + D+ V GG+++L+ ++L GA ++ I + AL P ++ RFG Sbjct: 63 HELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALARFG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 V+ +VV +D+ + + V + V V G ++ + + Sbjct: 123 VERVVVAVDSR----------DGWVATHGWETVQAIRVEEVVHRVVLLGVRRVLATDVTR 172 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG +LE + ++ V +IASGG G+ R V+ A+ ++ + Sbjct: 173 DGTLTRPNLELMGRLA-ALGVTVIASGGVGSRSDLEALARVPGVEAAIVGRALYEGRVRF 231 Query: 242 G 242 Sbjct: 232 E 232 >UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=142 Tax=cellular organisms RepID=HIS4_METNO Length = 253 Score = 223 bits (569), Expect = 4e-57, Method: Composition-based stats. Identities = 56/256 (21%), Positives = 107/256 (41%), Gaps = 16/256 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSD 57 M + P +D+++G+ V+ VQ + I D A +AE+G L D+ + Sbjct: 1 MTRVILFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFA 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G ++ + V + + IP + GGI+ + L+ G ++ I + A+ DP + A Sbjct: 61 GAPMNAAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFVREAA 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 F I VGID A+ G+ V + + + + + + G ++ Sbjct: 121 RLFPG-RIAVGID----AKDGRVAVEGW------AKTSTVTAEELGRRFEDAGVAALIYT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR--DADVDGALAASVFH 235 + +DGV G ++ + + +P+IASGG ++E A + GA+ + Sbjct: 170 DIARDGVLKGLNIPMTLALAQAVSIPVIASGGLASIEDVHRILEPDCALLAGAITGRALY 229 Query: 236 KQIINIGELKAYLATQ 251 I+ E A + Sbjct: 230 DGRIDPREALAAIRRA 245 >UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hisF n=2 Tax=Bacteria RepID=C9YDK8_9BURK Length = 286 Score = 223 bits (568), Expect = 5e-57, Method: Composition-based stats. Identities = 93/256 (36%), Positives = 136/256 (53%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L + +VKGV F + +G ++P K Y + DELV DI A G Sbjct: 27 MLKVRVIPTLLWKHFGLVKGVGFNSWRRVGPVLPAIKVYNQREVDELVLVDILAHGRGEE 86 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + + +P V GGI +E ++L GADK+S+N+ A A P L++ +A R Sbjct: 87 PDYESIHEFGQDCFVPLTVGGGITHIEQVQRLLRVGADKVSLNTAAYARPELVSDIARRH 146 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 GVQC+V ID A G + + G T+ T + + W +E++ RGAGEI++ ++ Sbjct: 147 GVQCVVASIDVRPRA-GGGWDCFSHAG----TQPTGRDVVAWARELEDRGAGEILVTSID 201 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG GYDL + V + +P+IASGGAG +H ++A A AAS+FH + Sbjct: 202 LDGSMRGYDLALVAAVAQAVKIPVIASGGAGNYQHMVDAVVQAGAAAVAAASIFHFTEMT 261 Query: 241 IGELKAYLATQGVEIR 256 KA LA GV +R Sbjct: 262 PAGAKAALAEAGVPVR 277 >UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrionales RepID=HIS4_DESDA Length = 250 Score = 223 bits (568), Expect = 5e-57, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 112/252 (44%), Gaps = 17/252 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+++G+ V+ Q R HE V A+ + E GA L D+ + DG Sbjct: 3 IFPAVDIQNGKAVRLKQGRAHESTVFAESPVDAARAWEEAGARWLHVVDLDGAFDGAAQS 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + IP + GGI+ + A L G ++ I + AL PTL + F Sbjct: 63 RRIVRDICAALAIPVQLGGGIRDMHTAEAYLEAGVSRLIIGTLALEQPTLFADMCRAFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + DAE G+ + D T T + GA ++ + +D Sbjct: 123 R-----VGVSLDAEGGRLKSRGWVEDTGMTVDTALP------RLLDDGAAFVIYTDIERD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF---RDADVDGALAASVFHKQII 239 G++ G ++ L+ + + VP+IA+GG T+E + + + + GA++ ++ + Sbjct: 172 GMQCGVNVAALEHLARLSTVPVIAAGGVATLEDIQKLYPLTLETSLMGAVSGRALYEGTL 231 Query: 240 NIGELKAYLATQ 251 ++ E A++ + Sbjct: 232 DLKEANAWIDAR 243 >UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Lactobacillus rhamnosus RepID=C7TCJ1_LACRG Length = 249 Score = 223 bits (568), Expect = 7e-57, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 107/246 (43%), Gaps = 14/246 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI--IGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+ GQ V+ Q ++ D + K G L D+ + + + Sbjct: 1 MQLYPAIDLLAGQSVRLTQGDYRQVSLTADPLTQVKNLTATGLKHLHLVDLDGARSQQPI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +++ +S + + + GGI++L L+ G D++ + S A+ +P L+T+ +FG Sbjct: 61 NQAVISTIRQHTPAFIELGGGIRTLAIMDHYLNAGIDRLILGSVAVTNPELVTQAVQKFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 I VGID A GK + + + +Q + +RG ++ + + Sbjct: 121 ADKIAVGID----ARAGKVATDGW------LTTSTQSPTHLMQAMVRRGVTTFIVTDIGR 170 Query: 182 DGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ G ++ L + + +V ++ASGG T+ A + A + A+ + Sbjct: 171 DGMMKGPNVALLAMLHQTVPNVNIVASGGVHTLADL-TALQTAGIQAAVIGKAWQTGSFP 229 Query: 241 IGELKA 246 + +LK Sbjct: 230 LNKLKE 235 >UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Halobacteriaceae RepID=HIS4_HALWD Length = 245 Score = 222 bits (567), Expect = 9e-57, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 111/247 (44%), Gaps = 14/247 (5%) Query: 6 IIPCLDVRDGQVVKGVQFRN--HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 +IP +D++DG VV+ VQ GD V AK++ E GA L D+ + +G ++ Sbjct: 10 VIPAVDMQDGDVVQLVQGERGTETRYGDPVVAAKQWVEAGAKTLHLVDLDGAFEGDRMNA 69 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + V + + +DIP + GGI++ DAA +L G +++ + + A+ +P L+ LA+ + + Sbjct: 70 TAVDAIIDAVDIPVQLGGGIRTANDAASLLDRGVNRVILGTAAVENPDLVAELAESYPGR 129 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 IV DA G+ V+ + T T + GA I+ ++ +G Sbjct: 130 IIV-----SLDAADGEVVVSGW------TESTGIDPAVAAARFADYGACGILFTDVDVEG 178 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 G +V + +P+IASGG +++ + + + ++ + + Sbjct: 179 KLAGIQSSVTARVIDAVDIPVIASGGVASLDDI-QTLHTTGAAATVVGTALYENKFTLAD 237 Query: 244 LKAYLAT 250 + Sbjct: 238 AMEVCES 244 Score = 62.8 bits (152), Expect = 1e-08, Method: Composition-based stats. Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 2/119 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 RII LD DG+VV V D A R+A+ GA ++F D+ + S Sbjct: 129 RIIVSLDAADGEVV--VSGWTESTGIDPAVAAARFADYGACGILFTDVDVEGKLAGIQSS 186 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 +RV + +DIP +GG+ SL+D + + GA + + + + + Sbjct: 187 VTARVIDAVDIPVIASGGVASLDDIQTLHTTGAAATVVGTALYENKFTLADAMEVCESD 245 >UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomycetales RepID=D2Q1W2_9ACTO Length = 256 Score = 222 bits (567), Expect = 9e-57, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 109/245 (44%), Gaps = 17/245 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +DV DGQ V+ VQ + GD + A + E GA+ + D+ A+ GR ++ Sbjct: 18 LLPAVDVADGQAVRLVQGEAGSETSYGDPLAAATAWQEAGAEWIHLVDLDAAF-GRGSNR 76 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ V +D+ ++GGI+ E L+ GA +++I + AL DP R+ +G Sbjct: 77 ELLADVTGRLDVQVELSGGIRDDESLEAALATGARRVNIGTAALEDPEWCDRVIQTYG-D 135 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + +G+D +T + + + ++ +++ G V+ + +DG Sbjct: 136 RVAIGLDV----RGRTLAARGWTKEGG-------DLYEVLERLERAGCERYVVTDVTKDG 184 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHKQIINI 241 + G +L+ + + P++ASGG +++ L V+G + + + Sbjct: 185 MLQGPNLDLYRDLCARTAKPIVASGGVSSLDDLRALATLVPDGVEGVIVGKALYAGAFTL 244 Query: 242 GELKA 246 E Sbjct: 245 TEALE 249 >UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodopirellula baltica RepID=HIS4_RHOBA Length = 253 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 106/248 (42%), Gaps = 18/248 (7%) Query: 3 AKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASS-DG 58 I P +D+R G+ V+ Q D V AKR+ E GA L D+ A+ D Sbjct: 11 RMEIWPAIDLRHGKPVRLRQGDYDQQTTFGDDPVEFAKRWQESGAKRLHLVDLDAARGDS 70 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 ++ V R+ E +P + GG++ +L+ G ++ + S AL DP + D Sbjct: 71 PDANRDAVQRIIEATGLPCQMGGGVRDEITIESLLNVGVTRLVVGSRALKDPDWFVEMCD 130 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR--GAGEIVL 176 ++ +V GID A GK + + ++ +++ R IV Sbjct: 131 KYPG-KLVAGID----ARDGKVATQGW------LETSDVSAFEFATKLRSRTENIAAIVY 179 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 + +DG+ G + E L ++ +PL+ASGG T + + + + A+ + Sbjct: 180 TDIAKDGMMQGPNFEGLAEMAAASDIPLVASGGVTTYDDIKQ-LVEMKMPAAIVGRSLYD 238 Query: 237 QIINIGEL 244 ++ +GE+ Sbjct: 239 GVMELGEV 246 >UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=24 Tax=Bacteroidetes RepID=HIS4_PARD8 Length = 239 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 113/246 (45%), Gaps = 15/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q D + +AK + G L D+ + +GR+++ Sbjct: 4 LIPAIDIIDGKCVRLTQGDYATKKVYNEDPLEVAKMFEGNGIRRLHVVDLDGAREGRIIN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + R+A + GG+K +D GA ++ S A+ +P + T +FG Sbjct: 64 YRILERIATRTSLIIDFGGGLKQEDDLEIAFESGAQMVTGGSIAVKNPEMFTSWISKFGS 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++G D A+ K ++ + T E + +++ +G +++ + +D Sbjct: 124 EKIILGAD----AKEKKIAISGW------EETTSQELVPFIKGYYDKGITKVICTDIARD 173 Query: 183 GVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G ++ K++R E+ + +IASGG ++E E +A + + ++ I + Sbjct: 174 GMLQGPAIDLYKEIRDEIPFLYIIASGGVSSIEDI-EKLSEAGIPAVIFGKAIYEGKIQL 232 Query: 242 GELKAY 247 +L + Sbjct: 233 KDLLRF 238 >UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Caulobacter RepID=HIS4_CAUSK Length = 241 Score = 221 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 55/250 (22%), Positives = 112/250 (44%), Gaps = 16/250 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D++DGQ V+ + + A+R+ +G L D+ + +G+ V+ Sbjct: 3 LYPAIDLKDGQCVRLLHGDMEKATVFNNSPADQAERFVRDGFSWLHVVDLNGAIEGKSVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + E I IP + GGI++LE + G ++ + + A+ DP L+ + A + Sbjct: 63 TAAVQSILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPDLVRKAARLWPE 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q I V +D GK V+ +TG ++ + + + + G +++ +++D Sbjct: 123 Q-IAVAVDV----RDGKVAVDGWTG------LSDLDAITLGKRFEDVGVAALIVTDISRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD--GALAASVFHKQIIN 240 G G ++E + ++ + +P+IASGG ++ V+ GA+ + I Sbjct: 172 GALTGVNVEGVGELADAVSIPVIASGGVASVADIERLKARPGVEIAGAILGRSLYAGTIR 231 Query: 241 IGELKAYLAT 250 E A Sbjct: 232 PAEALTIAAA 241 >UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Vibrio vulnificus YJ016 RepID=HIS62_VIBVY Length = 272 Score = 221 bits (564), Expect = 2e-56, Method: Composition-based stats. Identities = 81/257 (31%), Positives = 124/257 (48%), Gaps = 6/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IPC+ + VV+ F+N+ IG++ + DE++ DI AS + R Sbjct: 4 MLKIRLIPCIVTKGELVVQSFAFKNYLPIGNVKTAIDFFVNWDVDEIIVNDIDASKEFRE 63 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + VS A+ +P V GGIK+LE +L GADK++IN+ A+ DP I A F Sbjct: 64 PNVDLVSWAAKECFVPLTVGGGIKTLEHIRNLLKAGADKVTINTKAIDDPDFIKNAASVF 123 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI V +D K + + V ++ GAGEI+LN ++ Sbjct: 124 GSQCITVSVDAIKQGNVYKLYDYRDGRVLDVDVVDWVRKVE------SYGAGEILLNSVD 177 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG R GYD+E LK V + +P+IA GG G + E + AA++F + Sbjct: 178 RDGSREGYDVELLKTVSGIVSIPVIALGGIGRFDQLAEGAIEGGCQALSAANIFQHMEHS 237 Query: 241 IGELKAYLATQGVEIRI 257 KA + + +R+ Sbjct: 238 TIAAKAQMRNAKLNVRL 254 >UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Leptospirillum RepID=A3EUM5_9BACT Length = 247 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 109/248 (43%), Gaps = 15/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++ P +D+R+G+VV+ Q F + G D V A ++ E G L D+ + +G Sbjct: 1 MQLYPAIDIRNGKVVRLTQGRFDQETVYGEDPVRTALQFRERGVQHLHVVDLDGAREGVP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V++S + + + V GG++S + A+ G ++ + + A+ DP + + ++ Sbjct: 61 VNRSLIREIVKAFRGFVQVGGGVRSKDIASFYYDAGVSRLILGTAAIKDPVFLGSMIEQH 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 VGID ++ + + L+ + + + G V ++ Sbjct: 121 P-DLFYVGIDVKDES----------LAVNGWLDLDTQDPLEVMVRMSELGVRGFVYTDIH 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ +G + + + +R VP+IASGG + R+ VDGA+ + ++ Sbjct: 170 RDGLLSGPNFARYETLRRTVRVPVIASGGVRDISDIAR-LREIGVDGAIVGKAIYTGEMD 228 Query: 241 IGELKAYL 248 + E L Sbjct: 229 LTEALRLL 236 Score = 51.2 bits (122), Expect = 3e-05, Method: Composition-based stats. Identities = 20/112 (17%), Positives = 40/112 (35%), Gaps = 2/112 (1%) Query: 10 LDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRV 69 +DV+D + V D + + R +E G V+ DI + + + Sbjct: 128 IDVKDESLA--VNGWLDLDTQDPLEVMVRMSELGVRGFVYTDIHRDGLLSGPNFARYETL 185 Query: 70 AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + +P +GG++ + D A++ G D + +T G Sbjct: 186 RRTVRVPVIASGGVRDISDIARLREIGVDGAIVGKAIYTGEMDLTEALRLLG 237 >UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Thermus RepID=HIS4_THET2 Length = 235 Score = 220 bits (562), Expect = 3e-56, Method: Composition-based stats. Identities = 68/243 (27%), Positives = 110/243 (45%), Gaps = 14/243 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRN--HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+IP +D++ G+ V+ + GD V A R+ EEGA L D+ + G Sbjct: 1 MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRAL-GTGE 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 ++ V RVA + IPF +AGGI+SLE + LS GA + + + A+ DP L+ R+ + G Sbjct: 60 NREAVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVG 119 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V +D A + V+ + LD ++ + G ++ + + Sbjct: 120 PDRLAVALD----ARGLEVVVSGWQ------EAASASALDLLRAWAEMGVRTLLYTDVRR 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G D E + +VR LI GG + E + VDGAL ++ I + Sbjct: 170 DGTLLGLDREVVARVRAAWPHELIVGGGIASPEDL-HLLQALGVDGALIGKALYEGRIRL 228 Query: 242 GEL 244 E Sbjct: 229 KEA 231 Score = 47.0 bits (111), Expect = 7e-04, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 6/117 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI--TASSDGRVVD 62 R+ LD R +VV V + L + +AE G L++ D+ + G +D Sbjct: 122 RLAVALDARGLEVV--VSGWQEAASASALDLLRAWAEMGVRTLLYTDVRRDGTLLG--LD 177 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + V+RV V GGI S ED + + G D I + R Sbjct: 178 REVVARVRAAWPHELIVGGGIASPEDLHLLQALGVDGALIGKALYEGRIRLKEAVWR 234 >UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBX0_9FIRM Length = 234 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 108/242 (44%), Gaps = 15/242 (6%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+RD + V+ Q + + +A+ + + G L D+ A+ G++ + Sbjct: 3 IFPAIDIRDNKCVRLSQGDYDKQTVYFDNPFTVAEDFEKRGVKYLHIVDLDAALIGKLTN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ ++ V GGI+ E K + G D++SI + A+ D + +++++ Sbjct: 63 FDIIKKIITDTNMLIEVGGGIRGEEQIKKYVDIGVDRVSIGTKAVKDFAFLKEMSEKYPY 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I + +D + Y + + + D++ +++ IV+ + +D Sbjct: 123 -KISLSLDVKDE----------YVYIKGWSENSGILIWDYLDKIKDLPLTGIVVTDIKKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ +G E +K+++ ++ SGG +++ + ++ D G + ++ ++ Sbjct: 172 GMLSGPSFELYRKLKKATKHNIVVSGGVSSLDDINK-LKEDDTYGVIVGKALYENKFSVE 230 Query: 243 EL 244 ++ Sbjct: 231 DI 232 >UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Methanomicrobiales RepID=HIS4_METMJ Length = 239 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 114/250 (45%), Gaps = 14/250 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH--EIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 I P +D+ DG+ V+ VQ R + GD A R+ +EGAD L ++ + Sbjct: 1 MEIYPAVDILDGRCVQLVQGRPEAATVYGDPAAWAHRWLDEGADGLHVVNLDGAFGRARK 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + + GGI+S+EDAA L G D++ +++ A+ +P +I LA+ FG Sbjct: 61 NADLIRAFTRETETFTELGGGIRSVEDAAGWLDAGVDRVIVSTQAVREPEMIRTLAEEFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + ++ GID A G+ + + L W + + GAG ++ ++ Sbjct: 121 GERVMAGID----ARAGEVMIEGWERPAG-------SYLSWAERFESLGAGSLLYTNVDV 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 +G++ G +E + ++ VP++ SGG + + A RDA GA+ S + + + Sbjct: 170 EGLQQGIAIEPVTELLARVKVPVVVSGGISSPGD-VAALRDAGAAGAVLGSALYAGKVRL 228 Query: 242 GELKAYLATQ 251 E Sbjct: 229 PEAMEAAHAN 238 >UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillales RepID=HIS4_LACC3 Length = 238 Score = 219 bits (560), Expect = 5e-56, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 110/246 (44%), Gaps = 14/246 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI--IGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+ +G+ V+ Q ++ D + A+R + G L D+ + R + Sbjct: 1 MKLYPAIDLLNGKSVRLTQGDYDQVSLTEDPLYQAQRLTDAGFAHLHLVDLDGARAQRPI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +++ ++R+ E + GGI++L L+ G D++ + S A++DP L+ + RFG Sbjct: 61 NRTVITRIREQTSAFIELGGGIRTLAAMEIYLTIGIDRLILGSAAVSDPDLVEQAIARFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 I VGIDT GK N + +Q + +Q+RG ++ + + Sbjct: 121 SNRIAVGIDT----RAGKVATNGW------LTTSQQTANALLTAMQQRGVTTFIVTDIAK 170 Query: 182 DGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ G + + L +++ +IASGG + + A + A+ + I Sbjct: 171 DGMMQGPNAQLLADLQQAMPQATIIASGGISLLADLHR-LQTAGIQAAIIGKAWQTGAIE 229 Query: 241 IGELKA 246 + LK Sbjct: 230 LAMLKQ 235 >UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=12 Tax=Bacteria RepID=HIS4_BRAHW Length = 238 Score = 219 bits (559), Expect = 7e-56, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 115/248 (46%), Gaps = 15/248 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+++G+VV+ V+ D + + + E G+ L D+ +SDG ++ Sbjct: 3 ILPAIDLKNGEVVRLVEGNYDNKTTYFKDPLEVLDFFIESGSSYLHVVDLDGASDGETIN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +V + D+ V GGI++ + K L G + + + A+ + + +++ Sbjct: 63 FKTIEKVIKKCDLFVEVGGGIRNEDTIKKYLDIGVKRTILGTAAVENIDFTNNMINKY-K 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I V ID + V + + + +++++ ++ G I+ +++D Sbjct: 122 EHIAVSID----SRDRMIAVKGWK------EINKQDSVEFCMKLDSMGIDTIIYTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G +G +L+ K++RE +IASGG T E + RD ++GA+ ++ I++ Sbjct: 172 GKLSGTNLDIYKELREKISCNIIASGGV-TFEDEIIKLRDMKINGAIVGKAIYEGKIDLK 230 Query: 243 ELKAYLAT 250 ++ Sbjct: 231 KIIEIAKQ 238 >UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Thermoanaerobacter RepID=HIS4_THEPX Length = 235 Score = 219 bits (558), Expect = 1e-55, Method: Composition-based stats. Identities = 49/246 (19%), Positives = 110/246 (44%), Gaps = 16/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ + + V+ + + V +AK + E GA + D+ + G +V+ Sbjct: 3 LIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + V GGI++ E + S G + + S A+ D L+ +G Sbjct: 63 GNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYGE 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV D++ G+ V+ + T+ + ++ +++++ G I+ +++D Sbjct: 123 RTIV-----GIDSKNGEVAVSGW------LEKTKIKDMELAKKMKEIGVKTIIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G NG + + L+ + + V +IASGG ++E + ++ GA+ + IN Sbjct: 172 GTLNGPNFKALENILK-TGVQVIASGGISSIEDLKK-LKEMGAYGAIIGKALYIGKINFK 229 Query: 243 ELKAYL 248 + Sbjct: 230 SALEVI 235 >UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=C7PAV4_CHIPD Length = 389 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 110/248 (44%), Gaps = 15/248 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q ++ + + +AK + G L D+ + G VV+ Sbjct: 148 VIPAIDIIDGKCVRLTQGDYAQKKVYNEHPLEVAKAFESIGIRRLHLVDLDGAKKGAVVN 207 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A ++ GGIK+ +D + GA +I S A+ DP L + ++G Sbjct: 208 WKVLEAIAGKTNLVIDFGGGIKTEDDLRIVYENGAALATIGSIAVKDPALFSGWVKKYGA 267 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I +G D + K V + T+ D+++E K+G I + +D Sbjct: 268 DKIFLGADV----KEEKIAVGGW------LETTELSVFDFLEENVKQGVQHIFCTDIAKD 317 Query: 183 GVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G + +K ++ + +ASGG TM + A +A G + +++ I++ Sbjct: 318 GLLQGPSVALYEKILQRFPQIDFVASGGVSTMAD-VHALAEAGCSGVIVGKAIYEERISM 376 Query: 242 GELKAYLA 249 EL ++ Sbjct: 377 KELADFIK 384 >UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SPR8_NEMVE Length = 545 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 97/332 (29%), Positives = 157/332 (47%), Gaps = 76/332 (22%) Query: 2 LAKRIIPCLDVRD---GQVV--KGVQFRNHEII----------------GDIVPLAKRYA 40 LAKR+I L+VR G++V KG QF EII GD V L +R+ Sbjct: 214 LAKRVITSLNVRTNNMGELVATKGEQFEVREIISDDEGNKPVKGDVKAVGDPVELGERFF 273 Query: 41 EEGADELVFYDITASSDGRVVDKSWVS---RVAEVIDIPFCVAGGIKS------------ 85 +GADE+ F +IT+ + D + + + E I +PF V GGI+ Sbjct: 274 SDGADEIAFLNITSFRSSPIHDLAMLKLLRKCCERIFVPFTVGGGIRDIYALDPDSVEEG 333 Query: 86 ---------LEDAAKILSFGADKISINSPAL-------------ADPTLITRLADRFGVQ 123 LE AA GADK+S+ S A+ T I ++A+R+G Q Sbjct: 334 KPVMRQFSALEVAAMYFKSGADKVSVASDAVYAAEEFIASGHKKTGKTSIEKIAERYGRQ 393 Query: 124 CIVVGID------------------TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQE 165 +V+ +D Y G+ +V + + V+ Sbjct: 394 AVVLAVDTKTVYVPSPDSTKHHTVKARYPGPNGEKYVWWQCTVKGGRETRDVGAYELVKA 453 Query: 166 VQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADV 225 ++ GAGEI+LN +++DG +GYDL+ +K V+ +P+IAS GAG + F++ FR+ + Sbjct: 454 CEELGAGEILLNNIDRDGTNHGYDLDLVKMVKGAVSIPVIASSGAGHVSDFVDLFRETNA 513 Query: 226 DGALAASVFHKQIINIGELKAYLATQGVEIRI 257 DGA+A ++FH+ ++I ++K +L +G +R+ Sbjct: 514 DGAMAGAIFHRGEVDITDVKEHLRNEGFTVRL 545 >UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Euryarchaeota RepID=HIS4_METJA Length = 237 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 129/248 (52%), Gaps = 16/248 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D++D + V+ +Q ++ + + V +AK++ +EGA+ L D+ A+ G + Sbjct: 3 IIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAF-GTGNN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + + +++P V GGI++LE A +++S G D++ + + A+ +P I L G Sbjct: 62 RDVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIGK 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IV+ ++ + GK + + ++ ++E + + G I+ ++ + Sbjct: 122 DKIVLAVEC----KEGKVVIKGWK------EKVDKTPIEVIKEFEDK-VGYILFTNVDVE 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G +++ +K++ E +P+I SGG T+E +A ++ + G + S +K +I++ Sbjct: 171 GLLKGINVDIIKELIEKTDIPIIYSGGITTLEDI-KALKELGIYGVVIGSALYKGLIDLK 229 Query: 243 ELKAYLAT 250 + + Sbjct: 230 KALEIVKN 237 >UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillus RepID=HIS4_LACPL Length = 241 Score = 218 bits (556), Expect = 1e-55, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 109/243 (44%), Gaps = 15/243 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+R GQ V+ Q F+ +I D V A++ G +L D+ + GR + Sbjct: 4 IFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSGRPEN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + + + GGI++ E A + L G D++ + S AL DP L+ RL FG Sbjct: 64 FATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLSEFGG 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+G+D N Y + +Q + ++ + GA ++ + +D Sbjct: 124 ERIVIGLDG----------TNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTDVARD 173 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G +L +++ +V LIASGG + ++ + + + + + + Sbjct: 174 GTMQGPNLALYQELQAQVPTANLIASGGVRNLTD-VQVLQASGFKDVIIGKALAEGGVTL 232 Query: 242 GEL 244 EL Sbjct: 233 AEL 235 >UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Deinococci RepID=C1CY68_DEIDV Length = 251 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 48/240 (20%), Positives = 102/240 (42%), Gaps = 15/240 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 A IIPC+D++ G+ V+ + + A+ + E GA + D+ A+ GR Sbjct: 16 APLIIPCVDIQSGRAVRLYEGDPERETVYFDSPLDAARHWVERGAGLVHLVDLDAA-TGR 74 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 ++ + ++ + +P V GGI+ E A +L G ++ I + A+ +P L+ L Sbjct: 75 GENREVIRQITSELGVPVEVGGGIRDREAAEDLLRAGVHRVVIGTAAVRNPQLVADLIAA 134 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G + +VV +D + + + + G ++ + Sbjct: 135 HGPERVVVSLDAR----------GLEVATHGWAQGSGVNVAELTPGLADAGLELLIFTDV 184 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G + E +++VR++ LI GG M+ + ++ ++GA+ ++ + Sbjct: 185 TRDGTLKGLNRELMRQVRQLWINTLIVGGGVANMDD-VRLLQEERIEGAIVGRAIYEGTL 243 >UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Faecalibacterium prausnitzii M21/2 RepID=A8S9L9_9FIRM Length = 239 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 101/243 (41%), Gaps = 16/243 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++ P +D+R GQVV+ Q + + G D A+ + GA L D+ + DG + Sbjct: 1 MQLFPAIDLRGGQVVRLTQGDYDRMTVYGQDPCAQARSFVAAGAKNLHVVDLDGAKDGTL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ +A+ + V GGI++ E K LS G + + S A+ D R+ ++ Sbjct: 61 SNYDTIAALAKQGGLYIEVGGGIRTEERIEKYLSLGVGRCILGSVAVTDFAFTARMLQKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G I VG+D + Y V+ + + + + + G I+ + Sbjct: 121 G-DKIAVGVDAK----------DGYVAIHGWKEVSAEPGVAFCKRLAEAGCTAIIYTDIA 169 Query: 181 QDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG G +L +++ EV V ASGG + LE + A+ + + Sbjct: 170 CDGAMQGTNLSLYRQLAAEVPGVAFTASGGISSEAELLE-LQQMGTAAAILGKSLYTGAL 228 Query: 240 NIG 242 ++ Sbjct: 229 DLA 231 >UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41EB6 Length = 246 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 123/248 (49%), Gaps = 15/248 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 I+P +D+R G+ V+ VQ + +I + +AK++ + GA+ + D+ + + Sbjct: 7 KMLIMPAVDIRGGKCVQLVQGKPGSEQVVIENPEKVAKKWEDAGAEVVHVIDLDGALE-S 65 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V + + ++ + +P + GGI+S+E A ++L+ D++ I + + +P +I++L++ Sbjct: 66 VTNIETIKKILNEVSVPIQLGGGIRSIEYAEELLNLDIDRLIIGTMGIKNPEIISKLSNE 125 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 +G + +++ +D ++ K + + + +E Q+ GAG I+ + Sbjct: 126 YGSERVMISLD----SKDNKVVIKGWQ------EKIDKSASEISKEFQELGAGSILFTNV 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 + +G+ G+ ++ + + + +P++ SGG +++ + + G + S +K I Sbjct: 176 DVEGLLGGFYVDPVIDLVDSVDIPVVYSGGVTSLDDLKQ-LQTTGAKGVVIGSALYKDKI 234 Query: 240 NIGELKAY 247 + + Y Sbjct: 235 KLEDALKY 242 >UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=16 Tax=Campylobacter RepID=HIS4_CAMJD Length = 244 Score = 216 bits (552), Expect = 4e-55, Method: Composition-based stats. Identities = 60/251 (23%), Positives = 109/251 (43%), Gaps = 13/251 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IIP LD+ DG+VV+ V+ + + K Y + GA EL D+T + D Sbjct: 3 QIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKR 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++A+ + + V GGI+S E+ +L G ++ I S A+ D TL + +FG Sbjct: 63 QLVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + IV+ +DT E VN + + + E LD+ +G I+ +++ Sbjct: 123 SEAIVLALDTILK-EDYVVAVNAW---QEASDKKLMEVLDF---YSNKGLKHILCTDISK 175 Query: 182 DGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG G ++ K + E+ + + ASGG +++ G + + + Sbjct: 176 DGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDLENL--KGICSGVIVGKALLDGVFS 233 Query: 241 IGELKAYLATQ 251 + E L Sbjct: 234 VEEGIRCLQNA 244 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 216 bits (551), Expect = 6e-55, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 107/250 (42%), Gaps = 15/250 (6%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DG+ V+ + F +I D V AK+Y L D+ + G+ V+ Sbjct: 2 IFPAIDLQDGRSVRLYKGDFAQETVINPDPVDQAKQYEAAKVGALHLVDLDGAKAGKPVN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V V + GGI+ E LS G D++ + S AL +P L ++ +G Sbjct: 62 VDIVKAVRAAFTGILEIGGGIRDKEAVDLYLSLGVDRVILGSVALKNPKLTKQVIAEYGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+G+D + GK + + D + + + GA ++ +++D Sbjct: 122 EHIVIGVD----GKNGKVAAEGW------LDQSDVPMTDLIGAMIEGGAKYFIVTDVDRD 171 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + E L + +E ++ASGG +E ++ V ++ ++ I + Sbjct: 172 GTMQGANEELLGNLQKEFPTARIVASGGVRNLEDI-KSLEQKGVMDSIVGKALYEGTITL 230 Query: 242 GELKAYLATQ 251 E+ Y + Sbjct: 231 EEIGEYNQQK 240 >UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes: glutamine amidotransferase; cyclase], putative n=6 Tax=cellular organisms RepID=B9WJS1_CANDC Length = 622 Score = 216 bits (551), Expect = 6e-55, Method: Composition-based stats. Identities = 91/329 (27%), Positives = 145/329 (44%), Gaps = 73/329 (22%) Query: 2 LAKRIIPCLDVR---DGQVV--KGVQFR----------------NHEIIGDIVPLAKRYA 40 L +RII CLDVR DG +V KG Q+ +G V LA +Y Sbjct: 288 LTRRIIACLDVRTNDDGDLVVTKGDQYNVREQQSSSSKISENSNQVRNLGKPVELATKYY 347 Query: 41 EEGADELVFYDITASSDGRVVDKSWV---SRVAEVIDIPFCVAGGIKSLEDAAK------ 91 +GADE+ F +IT+ + + D + + AE I +P V GGIK L D+ Sbjct: 348 NQGADEITFLNITSFRNSPLKDLPMLQVLRKSAETIFVPLTVGGGIKDLYDSETKKIIPA 407 Query: 92 ------ILSFGADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGIDTW 132 GADKISI S A+ + I ++ +FG Q +V+ +D Sbjct: 408 VDIAHLYFQSGADKISIGSDAVIIAENYYANNQIPLGTSSIETISSKFGNQAVVISVDPK 467 Query: 133 YD----------------------AETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 G+ + + ++ + L+ +K G Sbjct: 468 RKYIKNPQLDTTMETIKIIDPLQYGPNGEQYCYYQVTSQGGRKLHELGALELCLACEKLG 527 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-DADVDGAL 229 AGEI+LN ++ DG G++L+ L++++ +P+IAS GAG +HF + F D +D AL Sbjct: 528 AGEILLNSIDNDGSNKGFNLQLLQQIKSHVSIPVIASSGAGNPQHFQQVFEMDCGIDAAL 587 Query: 230 AASVFHKQIINIGELKAYL-ATQGVEIRI 257 A +FH+ + E+K YL +++R+ Sbjct: 588 GAGIFHRGEYTVNEVKKYLQQEAKMDVRL 616 >UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQP1_9RICK Length = 238 Score = 216 bits (550), Expect = 8e-55, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 108/247 (43%), Gaps = 14/247 (5%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIG-DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DG+ V+ + F + + AK + ++G + L D+ + + Sbjct: 3 IYPAIDLQDGKCVRLTKGDFEQQTVYSRSPIEQAKAFEDKGFEFLHVVDLDRTIHKEKSN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + + V GG+++ + +++ G + + + A+ DP L+ ++ ++ Sbjct: 63 LKTIKEIIQSTGLKVQVGGGLRTKDTVEEVIDLGVENAVMGTAAVNDPDLLIEISQKYKN 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VG+D + T+ D+++ ++ I+ +N+D Sbjct: 123 -KISVGLDVRDKM----------IALKGWKDQTEISCFDFLETIKNLPLKSIIFTDINKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G++ G +++ K+ E ++P+ ASGG +++ + G + + +I++ Sbjct: 172 GMKQGINIDDTLKMAESSNIPVTASGGVSSIDDIKLIKSKKKISGVVVGKAIYDGLIDLN 231 Query: 243 ELKAYLA 249 EL + A Sbjct: 232 ELVKFNA 238 >UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UE29_9RHOB Length = 261 Score = 215 bits (549), Expect = 9e-55, Method: Composition-based stats. Identities = 80/268 (29%), Positives = 131/268 (48%), Gaps = 18/268 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS---D 57 ML R+IP L + +GQ+V+ F H+IIGD + R+ E DEL++ DI+ ++ Sbjct: 1 MLMPRLIPVLLLMNGQLVRSETFTTHQIIGDPLHEVARFNEWKVDELIYLDISRTAGLAQ 60 Query: 58 GR--------VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALAD 109 GR + VA +P G + SL+ I GADK++IN+ A Sbjct: 61 GRRDAGNRAYADAMDVLEAVASHCFMPLTWGGHVTSLDQVRDIFKRGADKVAINTAAYET 120 Query: 110 PTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR 169 P LIT+++ RFG Q +VV ID + + T + + W +E + R Sbjct: 121 PDLITQVSKRFGAQAMVVSIDARQIENGYEVMT------QGGRTATGRDPVSWAKEAEDR 174 Query: 170 GAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGAL 229 GAGEI+L +++DG GYD +++V + +P+IA G G EH+ + + A Sbjct: 175 GAGEILLQSLDRDGRGTGYDTTLIEQVSQAVTIPVIACSGVGVYEHYAKGLKAGADAVAA 234 Query: 230 AASVFHKQIINIGELKAYLATQGVEIRI 257 A +++H + + K L G ++R+ Sbjct: 235 A-NIWHFKELADRGGKRALQRAGFDVRM 261 >UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L5A7_9DELT Length = 261 Score = 215 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 89/256 (34%), Positives = 136/256 (53%), Gaps = 7/256 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+IP + V+ G VV+ + FR + +G + + DE+V I D Sbjct: 1 MLKKRLIPVVLVKQGLVVQSIGFRRYLPVGRPKITVEFFNRWDCDEIVLLAIDREPDL-A 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V+ +P V GG++ +ED ++L GADK+S+N+ A DP LITR A+ F Sbjct: 60 RLAGLTAHVSGAAFVPLTVGGGVRRIEDFQELLRAGADKVSLNTAAFRDPELITRAAEAF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV ID A G+Y V G E T + D+ +E ++RGAGEI+LN ++ Sbjct: 120 GNQEVVVSIDARRHA-DGRYEVFVGGGRE----ATGADPRDFAREAERRGAGEILLNAID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + GYDLE +++V +P+IA GG G +EH EA A A+++FH + Sbjct: 175 RDGGKQGYDLELVRRVATAVSIPVIALGGVGRIEHVPEAIGAGAAA-AAASNIFHHIEHS 233 Query: 241 IGELKAYLATQGVEIR 256 K + G+ +R Sbjct: 234 TILAKQAMHKAGIAVR 249 >UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Legionella pneumophila RepID=HIS4_LEGPL Length = 239 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 109/248 (43%), Gaps = 15/248 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGD---IVPLAKRYAEEGADELVFYDITASSD 57 ML +IP +D++ G+ V+ Q R ++ + A +A+ GA L D+ + Sbjct: 1 ML---VIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARS 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G++ + + + I GGI+S+E A + + G ++ I S A+ +P L ++ Sbjct: 58 GKMQQLELICSM-QKTGIAIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQII 116 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 ++ + IV+ +D D + +N + ++ + + WE + + + G I+ Sbjct: 117 EKIKPENIVLALDVRVDTKVPLLAINGW---QNNSTSSLWEVVSY---YENHGIKHILCT 170 Query: 178 MMNQDGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 + DG+ NG + + ++ E + ASGG M+ + + + ++ Sbjct: 171 DIACDGMMNGPNFDLYQQAVEYFPQIAWQASGGIRHMQDI-TTLGSLGISAVILGLMLYQ 229 Query: 237 QIINIGEL 244 +N EL Sbjct: 230 DNVNFEEL 237 >UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G189_ABIDE Length = 238 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 115/247 (46%), Gaps = 15/247 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 M A I P +D+ +G+VV+ ++ ++ ++V A G + L D+ + + Sbjct: 1 MAAMIIFPAIDIYEGKVVRLLKGDYNKMTIYSENVVDKACEIEAAGGEWLHLVDLEGAKE 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G + ++V + + + + GGI++ K ++ G ++I + + A D + ++ Sbjct: 61 GNTPNFTYVEEICKKTGLKVEIGGGIRTEATIEKYINAGVNRIILGTKAATDKEFLNKMT 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 D++ + I VGID + K + + VT D+V E+++ G I++ Sbjct: 121 DKY-REKIAVGIDV----KDEKVAIKGW------LEVTDKTIFDFVTELKEIGIKNIIVT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + +DG +G ++ +K+ + + + ASGG T++ + ++ + GA+ + Sbjct: 170 DIAKDGAMSGINVSFYEKLSKFTDMDITASGGVTTLDDLIR-LKNTGIYGAILGKAMYTG 228 Query: 238 IINIGEL 244 +++ E Sbjct: 229 NVDLREA 235 >UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Nannocystineae RepID=D0LIZ1_HALO1 Length = 239 Score = 214 bits (545), Expect = 3e-54, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 97/251 (38%), Gaps = 15/251 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D+ G VV+ Q + E + + +R+A GA+ + D+ + G Sbjct: 1 MKIYPAIDLLGGNVVRLHQGKRSEALVYSNEPAEIVRRFASAGAERVHVVDLDGAFSGER 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ +A +P V GGI+ + + GA + + A+ +P Sbjct: 61 AHREALAEMAAASPVPLQVGGGIRDRAALEAVFATGAGFAVLGTAAVKNPAFAREACAAH 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 C++V +D A G + + + + GA ++ + Sbjct: 121 PG-CVIVAVD----ARDGVVAIEGWV------ESAGITAEELGKRAADWGAAGLLYTDVM 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + G ++ + + +P+IASGG GT++ A A V + ++ Sbjct: 170 RDGAQVGPNIATTAALAQAVDIPVIASGGVGTLDDI-RALAAAGVPSVVVGRALYENKFT 228 Query: 241 IGELKAYLATQ 251 + E A + Sbjct: 229 LPEALAAARGE 239 >UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=104 Tax=Bacteria RepID=HIS4_CLOB1 Length = 242 Score = 213 bits (543), Expect = 4e-54, Method: Composition-based stats. Identities = 59/248 (23%), Positives = 126/248 (50%), Gaps = 15/248 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I+P +D+++G+ ++ Q + + D + +A ++ E GA+ + D+ + G + + Sbjct: 3 ILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIKN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S +S + + I+IP + GGI++L ++ G +++ + + AL + L+ ++ Sbjct: 63 LSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKY-D 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I +GID A+ K +N + V+ +D+ +E++K G I+ +++D Sbjct: 122 EKIAIGID----AKNEKVAINGW------LNVSSINYIDFAKEMEKIGVRNIIFTDISKD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G +L+QL+K+ E + +IASGG +E + ++ DV GA+ + IN+ Sbjct: 172 GTLKGPNLKQLEKLNESINCNVIASGGIKDIEDL-KGIKEMDVYGAIVGKAIYSGNINLN 230 Query: 243 ELKAYLAT 250 E + Sbjct: 231 EAIKIINK 238 >UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Methanocaldococcus RepID=C9RH20_METVM Length = 237 Score = 213 bits (543), Expect = 5e-54, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 123/242 (50%), Gaps = 16/242 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++D + V+ +Q + + D V +AK++ +GA+ L D+ A+ G + Sbjct: 3 VIPAVDLKDKKCVQLIQGDPTKKHLELEDPVNVAKKWVHDGAEYLHIVDLDAAL-GCGNN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ E ++IP V GGI+SL A +++ G DKI + + A+ DPT + L Sbjct: 62 VDVIEKIVEEVNIPVEVGGGIRSLTIAKRLMDIGVDKIVVGTKAITDPTFLNELLSEIER 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++ ++ + GK + + ++ ++ +K+ G I+ ++ + Sbjct: 122 EKIILAVEC----KQGKVAIKGWK------ETINKNPIEIAKKYEKK-VGGILFTNVDVE 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ +G + ++ + + VP+I SGG T+E + ++ VDG + S +K IIN+ Sbjct: 171 GMLSGIKTDIIETLVKNVRVPIIYSGGITTLEDIKK-LKEIGVDGVIIGSALYKGIINLK 229 Query: 243 EL 244 + Sbjct: 230 DA 231 >UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=117 Tax=Enterobacteriaceae RepID=HIS4_BLOFL Length = 251 Score = 212 bits (541), Expect = 9e-54, Method: Composition-based stats. Identities = 43/247 (17%), Positives = 102/247 (41%), Gaps = 12/247 (4%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP LD+ +G V+ Q + + G+ + Y ++GA + D+ + + + Sbjct: 2 IIPALDIINGDAVRLYQGKYQSQSHYGNPYSILSTYVQQGATMIHLVDLDGARNPKNRQL 61 Query: 64 SWVSRVAEVI---DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 S + + + + GGI+ D +L FG +++ + S A+ P + + F Sbjct: 62 SLIKELTHTAITSHLKIQIGGGIRHATDIKTLLKFGVNRVILGSIAITHPKKVKQWFTYF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 +V+ +D + D++ + V + T + + ++ G ++ ++ Sbjct: 122 NPSSLVLALDIYIDSKNNRKVV-----IHGWQKETNIQLEEVIENYNSVGLKHVLCTDIS 176 Query: 181 QDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G ++ + + + + ASGG + L+ R + V+ + F ++ Sbjct: 177 KDGTLLGSNINLYQSICYKWPKISFQASGGVAKLTEILQ-LRSSGVNSIIIGRSFLEKKF 235 Query: 240 NIGELKA 246 + E + Sbjct: 236 TLTEAIS 242 >UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=HIS42_PHOLL Length = 258 Score = 212 bits (541), Expect = 9e-54, Method: Composition-based stats. Identities = 50/258 (19%), Positives = 107/258 (41%), Gaps = 23/258 (8%) Query: 1 MLAKR---IIPCLDVRDG---------QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELV 48 M++K I P +D+ DG ++ +G +G +A + GA + Sbjct: 1 MISKETFEIFPSVDIVDGIAMTSNSAIRLTRGESSTLRRPLGTPAEVALAWQNAGAKWIH 60 Query: 49 FYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALA 108 D+ A+ GR + ++ V +DI V GGI+ K+L+ G ++++ + AL Sbjct: 61 VVDLDAA-SGRGSNSHLIADVLAAVDINVQVCGGIRDETILRKVLATGCQRVNLGTAALE 119 Query: 109 DPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQK 168 +P + +G I + +D +E + + + V++ D ++ + K Sbjct: 120 NPDWCAQAIAEYG-DKIAIALDVKSTSEGYQLATHGWN-------VSKGNLWDLLERLDK 171 Query: 169 RGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVD 226 +G V+ + + G+ + + L++V P+IA GG +++ V+ Sbjct: 172 QGCQRYVVTDVERGGMMSSPNFTLLQEVCAKTSSPVIAGGGVSSLDDLRALADLSTIGVE 231 Query: 227 GALAASVFHKQIINIGEL 244 GA+ H + + + Sbjct: 232 GAILGQALHIGKVPLEDA 249 >UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WSE3_VEREI Length = 229 Score = 212 bits (541), Expect = 9e-54, Method: Composition-based stats. Identities = 80/218 (36%), Positives = 119/218 (54%), Gaps = 6/218 (2%) Query: 39 YAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGAD 98 Y +GADELVF DI AS R + R A+ I +P V GGI+SL D +L GAD Sbjct: 17 YYSQGADELVFMDIVASLYQRNNLAGIIERAADQIYVPITVGGGIRSLHDVRTMLCSGAD 76 Query: 99 KISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWE 158 K++IN+ A+A P LI +++RFG QC+V+ ++ + G ++ T + Sbjct: 77 KVAINTAAVARPGLIAEVSERFGSQCMVLSVEAKRKSGGGW-----EAFVDNGREHTGLD 131 Query: 159 TLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 + WV++ GAGEI+L ++Q+G R G+D++ ++ V VP+IASGG G + Sbjct: 132 VVAWVRQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTVAGCVTVPIIASGGYGRPSDLQQ 191 Query: 219 AFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIR 256 A +A G A H Q I ELKA+ G+E+R Sbjct: 192 A-AEAGASGLAIADALHWQRATIAELKAHARAAGLEVR 228 >UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZT22_9SPHI Length = 239 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 54/238 (22%), Positives = 101/238 (42%), Gaps = 15/238 (6%) Query: 14 DGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVA 70 +GQ V+ Q D + +A++YA+EG L D+ + G + V ++A Sbjct: 12 NGQCVRLTQGDYSQKRVYDKDPIEMAQKYADEGFQRLHVVDLDGAKSGAPKHLALVEQMA 71 Query: 71 EVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGID 130 ++ GGIK+ E +L GA +I S A+ P + FG I++ D Sbjct: 72 AKTNLTIDYGGGIKTTEQVQAVLDAGAAMANIGSLAVKQPEVFKGWLQTFGSDKILLASD 131 Query: 131 TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDL 190 + K +N + ++ D++ + G + +++DG+ G L Sbjct: 132 V----KGEKIAINAWQ------DESEVSIYDFIADFIPSGLTQFFCTDVSKDGLLQGVAL 181 Query: 191 EQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAY 247 E K+++ + +IASGG +M+ E +DG + ++ I + ELK + Sbjct: 182 ELYCKLKQKFPTMTIIASGGVASMQDI-EDLNKEGIDGVIVGKAIYENRIALEELKQF 238 >UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Planctomycetaceae RepID=A6C5Q1_9PLAN Length = 246 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 104/253 (41%), Gaps = 21/253 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+R G+ V+ Q + GD +A+R+A+ GA L D+ + G+ Sbjct: 1 MEILPAIDIRGGKCVRLRQGDYGQETVFGDDPTEMARRWADGGAQRLHLVDLDGAKAGQP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKIL-SFGADKISINSPALADPTLITRLADR 119 V+ V ++ E + +P + GGI+ +L G D++ + + AL DP ++ R Sbjct: 61 VNHEVVRKIVEAVSVPCQMGGGIRDEASIQLMLDEVGIDRVIVGTQALKDPQWFKQMVQR 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 + + +G+D + E V++ +D +E ++ + Sbjct: 121 YPN-RLALGLDAR----------DSKVATEGWLDVSETSAIDLAKEYVGVELAAVIYTNI 169 Query: 180 NQDGVRNGYDLEQLKKV--REVCHVPLIASGGAGTMEHFLEAFR----DADVDGALAASV 233 DG+ G D ++ + +P+IASGG T++ + GA+ Sbjct: 170 ANDGMMQGVDEGTIQDMIALAELGLPVIASGGVTTLKDVSRLAEVSRTQPKLVGAIIGRA 229 Query: 234 FHKQIINIGELKA 246 ++ I + Sbjct: 230 LYEGTIEVPAAIE 242 >UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Deinococcus RepID=HIS4_DEIGD Length = 243 Score = 211 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 47/241 (19%), Positives = 101/241 (41%), Gaps = 15/241 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDG 58 L IIPC+D++ G+ V+ + + A+ +A GA + D+ A+ G Sbjct: 8 LQPLIIPCVDIQSGRAVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDAA-TG 66 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R +++ ++++ + +P V GGI+ A +L G ++ I + A+ +P L+ L Sbjct: 67 RGENRAVITQITAELGVPVEVGGGIRDRAAAEALLDAGVGRVVIGTAAVKNPALVRELIA 126 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G +VV +D + + + + G ++ Sbjct: 127 AHGPSRVVVSLDAR----------GLDVAIHGWAEGSGVSVAELAPLLAEAGLETLIFTD 176 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 + +DG G D + +++VR++ LI GG T++ + + + GA+ ++ Sbjct: 177 VTRDGTLRGLDRDLMRQVRQLWSNTLIVGGGVATLDD-VRLLAEEGIQGAIVGRAIYEGT 235 Query: 239 I 239 + Sbjct: 236 L 236 >UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=21 Tax=Bacteria RepID=HIS4_XYLF2 Length = 269 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 107/246 (43%), Gaps = 10/246 (4%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P LD+R+G VV+ Q R ++P A+ +A+ GA + D+ A+ G Sbjct: 5 VYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYTL 64 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + GG++S +D A+IL GA ++ I S A+ T + FG Sbjct: 65 APLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFGP 124 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I V +DT DA G + + + T V + Q+ G ++ + +D Sbjct: 125 ERITVALDTRQDA-GGVWRLPVH----GWTEVAEATLEALAQQYAAAGLRHLLCTDIARD 179 Query: 183 GVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ +G +++ +R + V + SGGA + + A + A G + + + + Sbjct: 180 GMLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAA-KMAGCAGIVLGKALLEGRLAL 238 Query: 242 GELKAY 247 E + Sbjct: 239 KEAVQH 244 >UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Coriobacteriaceae RepID=C8WPG6_EGGLE Length = 257 Score = 210 bits (535), Expect = 5e-53, Method: Composition-based stats. Identities = 47/242 (19%), Positives = 105/242 (43%), Gaps = 15/242 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++P +D+ G+ V+ + + D A+ + E+GA L D+ + G + Sbjct: 3 LLPAIDILGGKAVRLAKGDYDRVTVYHDDPAAQAQLFEEQGATWLHVVDLDGARSGIPEN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V R+ + V GG++SL+ A++ G ++ + + +ADP ++G Sbjct: 63 IAIVERIMRKTLLKVEVGGGVRSLDTIARLADAGVSRVVLGTSLVADPDFAEAAIAQYG- 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + GID A+ G+ V + + +++ G +V + +D Sbjct: 122 KLLCAGID----AKGGEVAVAGW------REGAGVAAEELARDMSALGFRHLVYTDIARD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD-VDGALAASVFHKQIINI 241 G++ G + ++ E P+IASGG ++ + A ++G +A ++ +++ Sbjct: 172 GMQTGIEAAAYVRMAEAFGHPVIASGGVAGVDDIVRLGEVAGSIEGVIAGRAVYEGALSV 231 Query: 242 GE 243 E Sbjct: 232 QE 233 >UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 n=15 Tax=Rhodobacterales RepID=HIS41_SILST Length = 247 Score = 209 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 53/258 (20%), Positives = 96/258 (37%), Gaps = 18/258 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSD 57 M+ I P +++ DG+ V + + D V AK +AE GA+ + D + Sbjct: 1 MM---IYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFN-ALQ 56 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G ++ V + +P + GGI+S E A + G ++ I + A DP + LA Sbjct: 57 GDSSNQDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELA 116 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + Q +V+ +D W E + W +V+ I++ Sbjct: 117 KYYPDQ-VVLAVDVW----------QGQVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVT 165 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 ++ D L + + E H P+IASG + + ++ GAL + Sbjct: 166 DIDSDMSDLDAQLGLISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNK 225 Query: 238 IINIGELKAYLATQGVEI 255 I + E + Sbjct: 226 TITLEEAMETAQPNPEPV 243 >UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=HIS4_BUCCC Length = 245 Score = 209 bits (532), Expect = 9e-53, Method: Composition-based stats. Identities = 49/251 (19%), Positives = 102/251 (40%), Gaps = 13/251 (5%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD G++V+ Q DI ++Y +GA + D+ ++ Sbjct: 2 IIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 KS + + ++ F V GGI+S D + G KI I + A+ P + +G Sbjct: 62 KSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGS 121 Query: 123 QCIVVGIDTWYD-AETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V+ +D + + K + + + T+ D +++ G I+ +++ Sbjct: 122 KNFVLSVDININTKKENKIAIQGWK------KTTEINLDDAIKQFIPYGLKNILCTDISR 175 Query: 182 DGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG +G ++ K ++ + ++ L +SGG ++ + +V+ + + Sbjct: 176 DGTFSGPNISLYKYLKNKFPNIVLQSSGGINSISDIYN-LKKNNVEHVIVGRALLENKFT 234 Query: 241 IGEL-KAYLAT 250 E K +L Sbjct: 235 FLEASKCWLKE 245 >UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alteromonadales RepID=HIS4_PSEHT Length = 242 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 47/243 (19%), Positives = 100/243 (41%), Gaps = 11/243 (4%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGDIVPL---AKRYAEEGADELVFYDITASSDGRVVD 62 IIP LDV Q+V+ Q + + L K YA+ GA +L D+ + D Sbjct: 2 IIPALDVLQNQIVRLYQGKYETVQFYPFELGARLKEYADSGAGKLHLVDLEGARDPSKKQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +++P+ V GGI+ +D + L GA+++ I S A+ + ++FG Sbjct: 62 WQHIQAATKALNVPYQVGGGIRCEQDVSDWLKAGANQVVIGSMAVEKREQVKAWIEQFGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V+ +D A + + +++ L+ V G + + +++D Sbjct: 122 EHFVIALDVNKTATGWAPATHGW------LTESEFGLLELVDFYANLGVIDFLCTDISKD 175 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + + + + + ASGG +++ + ++ + G + ++ Sbjct: 176 GTMTGPSFALYEDLIKHNSTIKVQASGGVSSLDDIKK-LKELGIGGIILGKSLLDGAFSV 234 Query: 242 GEL 244 E Sbjct: 235 EEA 237 >UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=1 Tax=Silicibacter lacuscaerulensis ITI-1157 RepID=D0CY30_9RHOB Length = 282 Score = 208 bits (530), Expect = 2e-52, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 105/255 (41%), Gaps = 15/255 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRV 60 R+ P +++++G+ V + R E + D V A+ +A GA+ + D + +GR Sbjct: 36 MRVYPTMELQNGRCVTLDKGRLDEPMIWHVDPVETAQGWAAAGAEWMHLTDFD-AIEGRD 94 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V ++ ++P +AGG +S E + + GA +I I + A DP L LA + Sbjct: 95 TNSALVEQIIRSAELPVQLAGGFRSREQVERWIDKGAGRIVIGTLAARDPHLFKELAKLY 154 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q IV+ +D W Y + + + +++ I++ ++ Sbjct: 155 PDQ-IVLAVDVW----------QGYVMTDGWRTQSAFSPEAFIEAFADAPLAAILVTDID 203 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 D V L + + P+IASG + + ++ G L ++ ++ Sbjct: 204 SDMVDVEAQLGLISGLAAHSRTPVIASGVVRSSDDISRLAYIPNISGVLVGRALFRKTVD 263 Query: 241 IGELKAYLATQGVEI 255 + E A T + Sbjct: 264 LSEALAVARTAHEPV 278 >UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Gammaproteobacteria RepID=HIS4_SHEDO Length = 250 Score = 208 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 100/252 (39%), Gaps = 19/252 (7%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ DGQVV+ Q + + K Y ++GA L D+T + D Sbjct: 2 IIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLKSYQDQGAKLLHIVDLTGAKDPNQRQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S + +D+ V GGI+S + ++L+ G ++ I S A+ +P L+ +++G Sbjct: 62 IKLISELVAGLDVDIQVGGGIRSEQQVTELLAIGVKRVVIGSLAVKEPELVKSWLNKYGS 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG-----AGEIVLN 177 I + +D +A K V E ++ G ++ Sbjct: 122 DAICLALDVNINANGEKI-----VAVSGWQSAGGKTLESLVAEFERPGSKQTALKHALVT 176 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLI---ASGGAGTMEHFLEAFRDADVDGALAASVF 234 +++DG G + ++ P I ASGG T++ + A +D+ G + Sbjct: 177 DISRDGTLTGANTALYTELAAA--YPTILWQASGGIATLDD-VSAVKDSKAAGIIIGKAL 233 Query: 235 HKQIINIGELKA 246 + E Sbjct: 234 LINQFTVEEAIQ 245 >UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6XVQ0_PEDHD Length = 288 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 77/256 (30%), Positives = 129/256 (50%), Gaps = 7/256 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+ L V+DG VV+ + F+ + +G + + G DE++ DI+A+ Sbjct: 1 MLKKRVAANLVVKDGIVVQSIGFKKYLPVGKPEIAIEFLNQWGIDEIILTDISATRKQSG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + R A+ +P V GGI + ++L GADKIS+N+ A+ P LIT A F Sbjct: 61 PDFDMIRRAAQKCFVPLTVGGGISNTGQMKELLHNGADKISLNNAAITTPELITETAHIF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ ID + + + + D ++ + + GAGEI++N ++ Sbjct: 121 GGQCVVISIDGIHTNKGFRIY------DYLTHSALDISPSEFAKRAEDSGAGEILINSVD 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G+D E + V V ++P+I GGA F+E F + A AA+ FH + Sbjct: 175 RDGSYLGFDHELINSVCSVVNIPVIVCGGAKNAGDFIEVFSKTNASAATAANFFHFSEHS 234 Query: 241 IGELKAYLATQGVEIR 256 + K+ L + +++R Sbjct: 235 VNITKSIL-NKKMDVR 249 >UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Leptospira RepID=HIS4_LEPBL Length = 241 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 103/249 (41%), Gaps = 16/249 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ D V+ + E + LA+ +A+ GA L D+ + + ++ Sbjct: 3 IIPAIDLFDNCAVRLFKGNYKEKKIYSSEPWKLAEGFAKNGATLLHLVDLNGARNQLGIN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + + + GGI+ E A G D+ + + A+ DP L+ D + Sbjct: 63 EDSILKIRKTTSLKVQLGGGIRDKEKLAYYDKIGIDRFILGTAAVTDPDLLKFALDNYEK 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV +D ++ + + D + + K G IV + QD Sbjct: 123 ERVVVAVD----------AIDGIVKIAGWEKDSGVRYRDLMDRLAKAGIEHIVFTDIAQD 172 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE---AFRDADVDGALAASVFHKQII 239 G G +L+ +++ +IASGG +++ ++ + G + ++ + Sbjct: 173 GTLAGPNLKAYQEILNSYPFQVIASGGISSLKDLMDLSSLKTKIPLYGVITGKALYEGKL 232 Query: 240 NIGELKAYL 248 ++ + + + Sbjct: 233 DLAKAISSI 241 >UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit HisF n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BR00_9RICK Length = 254 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 82/257 (31%), Positives = 135/257 (52%), Gaps = 10/257 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNH-EIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ML RII + +VKG +F N G + K Y DE++F+DI S + + Sbjct: 1 MLKARIITTMLWNGSTLVKGNKFENEKRSAGSPLTTVKIYNSRDVDEILFFDI--SRNNK 58 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 ++DK ++ + + + +P + GGI+ + + +GADK++INS +P +I + R Sbjct: 59 IIDKDFILSITDCVSVPITIGGGIEKISQMNDLFEYGADKVAINSIIYKNPNIIDEASKR 118 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG Q I V ID + + + + + + D + E RGAGEIV+N + Sbjct: 119 FGSQAITVSIDVRKNNQNYE------CYYDLGKIKSDRKLNDLLVECVNRGAGEIVINCI 172 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 N DG+ GYD E +++ + ++P++ASGGAG+ EHF EA+++ D AAS++H Sbjct: 173 NNDGLMKGYDNELIQQTSSLANIPIVASGGAGSYEHFYEAYKN-GADAFAAASIYHFTEH 231 Query: 240 NIGELKAYLATQGVEIR 256 + K YL + V IR Sbjct: 232 TPAKAKKYLLKKKVPIR 248 Score = 42.0 bits (98), Expect = 0.018, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 39/108 (36%), Gaps = 3/108 (2%) Query: 150 SRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGG 209 + + L V+ R EI+ ++++ D + + + + VP+ GG Sbjct: 24 ENEKRSAGSPLTTVKIYNSRDVDEILFFDISRNNKI--IDKDFILSITDCVSVPITIGGG 81 Query: 210 AGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 + + F + D S+ +K I E +Q + + I Sbjct: 82 IEKISQMNDLF-EYGADKVAINSIIYKNPNIIDEASKRFGSQAITVSI 128 >UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Opitutaceae RepID=HIS4_OPITP Length = 243 Score = 206 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 46/241 (19%), Positives = 98/241 (40%), Gaps = 19/241 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++ G+ V+ Q R + + +A ++ G++ + D+ + G + Sbjct: 3 IYPAIDIKGGRCVRLTQGRAEQETIYAQNPADVAMQFRAAGSEWVHVVDLDGAFAGEPQN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + + GG+++ + L+ G ++ + + A + + L FG Sbjct: 63 LAAVQAIV-AVGMKVQFGGGLRTRAAVERALALGVSRVVLGTRAAESESFVGELVQAFG- 120 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VGID A+ GK V + TL + + G ++ + D Sbjct: 121 DKIAVGID----AKNGKVAVKGWVAT------ADLSTLVLARRMDTLGVATLIHTDIGTD 170 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE----AFRDADVDGALAASVFHKQI 238 G+ G +L + + +IASGG + + A R A++DG + +++ Sbjct: 171 GMLTGPNLAAQEALCSAVKSRVIASGGVSRRDDVVNLAKLAQRHANLDGVIVGKALYERR 230 Query: 239 I 239 + Sbjct: 231 V 231 >UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Leptospira biflexa serovar Patoc RepID=HIS4_LEPBA Length = 247 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 45/257 (17%), Positives = 111/257 (43%), Gaps = 19/257 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 ML ++P +D+ D + V+ +Q + + + + E+GA + D+ A+ Sbjct: 1 ML---VLPAIDLLDNEAVRLLQGDYSKKTVYSSSPEKMIQVFEEQGATLIHIVDLNAAKT 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ ++ + ++ E + + GGI+++++ G ++ + + A+ +P ++ + Sbjct: 58 GKSENEKTIKKIKEKCTVDLELGGGIRTIDNMKFYDGLGVSRLILGTVAVEEPNVVEKAV 117 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 FG IV+G+D N Y + + D++ + G ++ Sbjct: 118 SLFGQDRIVIGVDAK----------NGYVRTKGWESNSGILYKDFLTTMYGMGIRHVIFT 167 Query: 178 MMNQDGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDAD--VDGALAASVF 234 + +DG+ G + ++ E + L+ASGG + E +E + + + GA+ Sbjct: 168 DIARDGMMEGPNTLAYAELLETFPDLQLVASGGVSSKEDLVELYDKTNGKLFGAITGKAI 227 Query: 235 HKQIINIGELKAYLATQ 251 ++ +++ E L + Sbjct: 228 YEGKLDLKESIRILNQK 244 >UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Zymomonas mobilis RepID=HIS4_ZYMMO Length = 250 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 97/252 (38%), Gaps = 16/252 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+++G VV+ + D A+++ E GA L D+ + G ++ Sbjct: 7 IFPAIDLKEGHVVRLSEGDMDRATIYDDDPAARARQFYEAGARYLHVVDLDGAFAGHAMN 66 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + + GGI+ + LS G ++ I + A +P L+ A ++ Sbjct: 67 AAAVDAIVKAFPGTIELGGGIRDMNAIDGWLSRGISRVVIGTAAFENPDLVKEAAQKYPG 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q IVV +D + + ++ D + G ++ + +D Sbjct: 127 Q-IVVAVDAR----------DGMVTTKGWAEQSEISVTDMAERFADAGVVALLYTDVGRD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHKQIIN 240 G++ G + E + +P+IASGG + R ++G + + ++ Sbjct: 176 GLKKGCNSEATLALAAATDIPVIASGGVKDIGDIELLARHTKDGIEGVICGRAIYDGSLD 235 Query: 241 IGELKAYLATQG 252 + A G Sbjct: 236 LKAALAIARQGG 247 >UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_SYMTH Length = 249 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 107/257 (41%), Gaps = 20/257 (7%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR--NHEIIG-DIVPLAKRYAEEGADELVFYDITASSDG 58 + + P +D++DGQVV+ Q R + G D V +A R+AE GA + D+ + G Sbjct: 1 MRLDLYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRG 60 Query: 59 RVVDKSWVSRVAEVI-----DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 R + + V + E + + + GG+++LE L+ G + I + AL + Sbjct: 61 RPQNAAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSALEG-DVA 119 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 R RFG + V ID + VT+ +D +++ G Sbjct: 120 ARAVARFGPDRVAVSIDAR----------GGFVAARGWVEVTRVRAVDLAVRMREVGVRT 169 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 +V + DG+ G + +L+ + + +IASGG ++E V GA+ Sbjct: 170 VVYTDIATDGMLTGPNFAELEMMGR-TGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRA 228 Query: 234 FHKQIINIGELKAYLAT 250 + +++ E + Sbjct: 229 LYTGAVDLAEALSLCGE 245 >UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Proteobacteria RepID=HIS4_DESOH Length = 251 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 55/250 (22%), Positives = 106/250 (42%), Gaps = 16/250 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ +Q D +A+R+AE GA+ + D+ + + + Sbjct: 3 VIPAVDIKGGKCVRLLQGDMNAETVFSDDPGAMAERWAEAGAELIHVVDLDGAIEKSPRN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S + + +P V GGI+ ++ G +I I S A+ P L+T F Sbjct: 63 LKAISALIRRVGVPVQVGGGIREIDTVKMYADLGVARIVIGSAAVNHPDLVTAACREFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 IV+GID A G+ + T T D + G I +++D Sbjct: 123 -RIVLGID----ARDGRVATEGW------TSTTDIAAADLAARFEGCGVAAINFTDIHRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF--RDADVDGALAASVFHKQIIN 240 G+R G ++ ++ +P++ASGG T++ ++ V G + + ++ Sbjct: 172 GMRTGPNIPAIEAFARATAIPVVASGGVSTIDDIQALLGIQEFGVTGVITGRALYDGTLD 231 Query: 241 IGELKAYLAT 250 + E A + Sbjct: 232 LAEAIAVASA 241 >UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N0X3_9GAMM Length = 240 Score = 205 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 105/246 (42%), Gaps = 16/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI-IGD--IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ Q + +I I D V A +A+ GA L D+ + G + Sbjct: 3 LIPAIDIQAGRCVRLKQGQFEQITIFDTPPVERAAYFAKIGAQRLHVVDLDGAQIGSMQQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + I GGI+SLE A S G + + S A+++ L T++ Sbjct: 63 LPLICSM-QNTGINVQAGGGIRSLEQAKLCFSAGIANLVLGSIAISNRELATQIIQEISP 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++ +D + G ++ + W+ + + Q+ G +I+ + D Sbjct: 122 KNIILALDIRL---INGIPIPATHGWQTMSNRNLWDVVSY---YQQLGIQQILCTDIACD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLI---ASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 G+ G + ++ + P+I ASGG E EA V A+ ++ + Sbjct: 176 GMMQGPNFSLYQEAVK--RFPMIDWQASGGIRNQEDI-EALDKLGVAAAILGLSLYQGTL 232 Query: 240 NIGELK 245 ++ E K Sbjct: 233 HLAEYK 238 >UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=B4W8G6_9CAUL Length = 243 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 105/253 (41%), Gaps = 14/253 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSD 57 ML I P +D++DG V+ + + ++ +A EGA+ + D+ + Sbjct: 1 ML---IYPAIDLKDGVCVRLMHGKFDQVTRYDEQPATRLSAFAAEGAEWIHVVDLDGAEA 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G V + + + + ID+ GG++S D AK+L G ++ + S A+ P + Sbjct: 58 GEAVQHALIGELTKAIDVKIQSGGGVRSANDVAKLLDTGVSRVVVGSLAVTQPNDVAAWL 117 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 FG + I + D + V G + V W LD K +++ Sbjct: 118 KGFGAEHITLAFDVKIED---GVPVPALKGWTQSSGVDLWTALD---RYPKGLFKHLLVT 171 Query: 178 MMNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 + +DG G +LE L ++ R + L ASGG +++ A + +GA+ ++ Sbjct: 172 DVGRDGAMTGPNLELLAEIRRRRPDLVLQASGGVSSLDDI-AAVKSLGCNGAIVGRALYE 230 Query: 237 QIINIGELKAYLA 249 + + A A Sbjct: 231 NRFTLPDAIATAA 243 >UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUX9_ALIAD Length = 252 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 116/252 (46%), Gaps = 19/252 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+ G+VV+ Q ++ GD +A R + GA L D+ A+ G+ + Sbjct: 8 VYPAIDILGGEVVRLRQGDYQQVTRYDGDPAGVAGRLCDAGARFLHVVDLDAARSGQSDN 67 Query: 63 KSWVSRVAEVI---DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + V + E V GGI++ + A+ L G ++ I + A+ ++ A Sbjct: 68 ERAVRAIVETAASYGAAVQVGGGIRTKDAIARWLEAGVARVVIGT-AVRQVEVVAEWAQE 126 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG +V G+D G+ V+ + T+W D +E+ K G + ++ + Sbjct: 127 FGGHRLVAGLDGRK----GRLAVSGW------LEETEWSIFDLARELAKVGLVQALVTDV 176 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G +L+ V+E + IASGG G+++ + A R A + GA+ H I Sbjct: 177 ERDGTGEGPNLDLALGVQE-TGLFAIASGGIGSIDDVV-AVRRAGLAGAVIGKALHDGRI 234 Query: 240 NIGELKAYLATQ 251 ++GEL LA + Sbjct: 235 HLGELFQRLAQE 246 >UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y7T0_9BACT Length = 237 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 47/244 (19%), Positives = 100/244 (40%), Gaps = 15/244 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+ GQ V+ + + D +A +A +GA +L D+ + +G + Sbjct: 3 IYPAIDLYAGQAVRLQRGDYARMTVYSDRPETVAADFAAQGARQLHLIDLEGAKNGGTPN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + V GGI+S++ L G D++ + + A R R+G Sbjct: 63 LETIVAVKKSSGLFCQVGGGIRSMDAIVAYLDAGVDRVILGTAAATQAHFAARAVARYGA 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I VG+D + + + T + + ++ + +Q G ++ +++D Sbjct: 123 -RIAVGVDIK----------DGFAAVKGWTEKSPLKAFEFCRRMQSDGVSTLICTDISRD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G ++ K + + +IASGG +++ + GA+ + + I+I Sbjct: 172 GMMQGTNVALYKTLSTELKMRIIASGGVSSLDDVRR-LAALGLYGAIIGKACYTKAISIA 230 Query: 243 ELKA 246 Sbjct: 231 AAIE 234 >UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LAC8_MAGSM Length = 260 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 69/224 (30%), Positives = 118/224 (52%), Gaps = 7/224 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDG 58 M R+IP L +++G++VK V+F + +GD V AK + ++ DEL DI+AS G Sbjct: 1 MRRIRVIPTLLLKEGRLVKTVRFNQAKATYVGDPVNTAKIFNDKEVDELAVLDISASRRG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 D V ++A +P GG+++L+ ++ G +K+ +N+ + L+ Sbjct: 61 AEPDFECVEQLASECFMPLLYGGGVRNLQQIQRLFHSGVEKVMLNTAFFSGSGLLQEAVK 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 +G Q + V ID D G+Y V + R T + + Q+ ++ GAGE++LN Sbjct: 121 IYGSQSLGVSIDVKKDLW-GRYRVMS----QGGQRKTGLDPVVAAQQAEQAGAGELLLNA 175 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRD 222 M+QDG++ GYDLE +++V +P+IA GGA ++ F Sbjct: 176 MDQDGMQQGYDLELVQRVSRGVAIPVIAVGGAASVADFRTVVTQ 219 >UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=uncultured marine bacterium 440 RepID=Q6SHC0_9BACT Length = 262 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 78/263 (29%), Positives = 137/263 (52%), Gaps = 17/263 (6%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD---GRVV 61 RIIP L +++G +V+ F H+ IG+++ AKR + DELV+ DIT + + GR Sbjct: 6 RIIPVLFIKNGLIVRSQNFYKHQFIGNVIEQAKRLNDYDVDELVYIDITRNDNYDLGRDD 65 Query: 62 DK--------SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 S + +++V +P GGI+S++DA + GADKI+INS D ++ Sbjct: 66 LLVKSKRDIMSIIKDISKVCFMPLTFGGGIRSVDDAVNRIRAGADKITINSLLYKDLNIV 125 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 ++ G Q +V ID K + G ++ T E +D++++++ G GE Sbjct: 126 KKIISEIGSQAVVASIDYKI--INEKLIIFNNFGQDN----TNIELIDFIKKIENLGVGE 179 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 + + DG++ G+DL +KK+ ++P+IA GAG++EHFLEA + + A + Sbjct: 180 FFIQNVELDGMQKGFDLNNIKKIVNSVNLPVIACSGAGSLEHFLEAVKIKGLSAVAAGNY 239 Query: 234 FHKQIINIGELKAYLATQGVEIR 256 F+ + + +K L + +R Sbjct: 240 FNYKERSYPIIKKELKDFNINVR 262 >UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms RepID=C1FJN8_9CHLO Length = 601 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 91/311 (29%), Positives = 139/311 (44%), Gaps = 58/311 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFR--------NHEIIGDIVPLAKRYAEEGADELV 48 LAKR+I CLDVR D V KG + + +G V LA +Y ++GADE+ Sbjct: 283 LAKRVIACLDVRSNDAGDLVVTKGDSYDVREKDDGNDVRNLGKPVELAGKYFKQGADEVA 342 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKS-----------LEDAAKILS 94 F +IT D + D + R +E + +P V GGI+ LE AA Sbjct: 343 FLNITGYRDLPLTDAPMLEVLRRSSETVFVPLTVGGGIRDFTDSNGVSYTALEVAAAYFK 402 Query: 95 FGADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGIDTWY-------- 133 GADK+SI S A+ T I ++++R+GVQ +VV ID Sbjct: 403 AGADKVSIGSDAVYVAEQYYANDKKKDGCTSIEQISERYGVQAMVVSIDPRRAYVADPSE 462 Query: 134 ----------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 G+ +V + + ++ G GEI+LN +++DG Sbjct: 463 TKNRCIKTSRPGPNGEEYVWFQCTVKGGREGRDIGAYELAIAMEDLGCGEILLNCIDEDG 522 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 NG+D E + V + +P+IAS GAG +HF + F ALAA +FH+ ++I E Sbjct: 523 QGNGFDHELVGLVADAVTIPVIASSGAGEPKHFTDVFNATKCSAALAAGIFHRGEVDISE 582 Query: 244 LKAYLATQGVE 254 +K ++ + Sbjct: 583 VKDHMKGGKIP 593 >UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n=3 Tax=Basidiomycota RepID=Q5KNA0_CRYNE Length = 619 Score = 204 bits (520), Expect = 3e-51, Method: Composition-based stats. Identities = 97/332 (29%), Positives = 142/332 (42%), Gaps = 78/332 (23%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFRNHEIIGD--------IVPLAKRYAEEGADELV 48 L RI+ CLDVR D V KG Q+ E D V LA+RY GADE+ Sbjct: 282 LTNRIVACLDVRSNDAGDLVVTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVA 341 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKS-----------LEDAAKILS 94 F +IT+ ++D V AE + +P + GGIK LE A Sbjct: 342 FLNITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFR 401 Query: 95 FGADKISINSPAL------------ADPTL-----ITRLADRFGVQCIVVGIDTWYD--- 134 GADK+SI S A+ +P L I ++ +G Q +VV ID Sbjct: 402 SGADKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVD 461 Query: 135 ------------------------------AETGKYHVNQYTGDESRTRVTQWETLDWVQ 164 E GK Q V + + Q Sbjct: 462 TSAPGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQ-CTISGGRAVRDIDVVQLAQ 520 Query: 165 EVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD 224 V++ GAGEI+LN +++DG G+DL+ +K V+ +P+++S GAG+ F E FR+ Sbjct: 521 GVERLGAGEILLNSVDRDGSGQGFDLDLVKLVKNAVGIPVVSSSGAGSPADFEEVFRETG 580 Query: 225 VDGALAASVFHKQIINIGELKAYLATQGVEIR 256 + ALAA +FH+ + I E+K +L + + +R Sbjct: 581 TEAALAAGIFHRGEVGIDEVKGWLEGKEMAVR 612 >UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RFK6_LEGLO Length = 246 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 106/243 (43%), Gaps = 12/243 (4%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D++ G+ V+ Q + ++ + A +A+ GA L D+ + G + Sbjct: 3 LIPAIDLQAGRCVRLRQGQFDQVTQFDMSPIDRASYFAKLGAKRLHIVDLDGAKIGTMQQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + + GGI+SLE A S G + I S A+ DP L T++ + Sbjct: 63 LPLICTM-QHTGVTVQAGGGIRSLEQAKTCYSAGISLLVIGSIAITDPGLTTKIINEISP 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I++ +D + K + G ++ + + WE + + Q+ G +I+ + D Sbjct: 122 KNIILALDIRME---NKIPLPATHGWQTTSTMNLWEVVSF---YQQLGITQILCTDIASD 175 Query: 183 GVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G + + ++ E ++ ASGG + + + + A+ ++ + N+ Sbjct: 176 GMMQGPNFDLYQEAVERFPNIAWQASGGIRHQDDINK-LQKLGIKAAILGLTMYQDVFNL 234 Query: 242 GEL 244 + Sbjct: 235 KSI 237 >UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sp. AT1b RepID=C4L175_EXISA Length = 237 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 60/246 (24%), Positives = 114/246 (46%), Gaps = 16/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R++P +D+ G++V+ + F E GD L K + + + D+ + G Sbjct: 1 MRLLPAIDLIGGKIVRLTEGDFSTEEQYGDPYELLKAWQGK-VPMIHLIDLEGAKAGEPR 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R A+ + GGI+S ++ GAD++ + + A DP + + +++G Sbjct: 60 HLDVV-RYAKSLGFLVQTGGGIRSEASLDAVMETGADRVLLGTKAFTDPDFLDKAIEKYG 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + + V +D + GK +N + T+ + + Q++ KRG I+ + Sbjct: 119 -KRVAVALDAY----DGKVAINGWQ------EATKLDDISVAQDLVKRGIETILYTDIGS 167 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG NG ++ ++K +R++ +V LIASGG T E E + A +D A+ ++I Sbjct: 168 DGKLNGPNVTRMKALRQIVNVTLIASGGVTTEEDVKE-LKMAKIDEAVVGKALLSGKVSI 226 Query: 242 GELKAY 247 EL + Sbjct: 227 EELIEW 232 >UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sibiricum 255-15 RepID=B1YL10_EXIS2 Length = 234 Score = 203 bits (516), Expect = 7e-51, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 114/243 (46%), Gaps = 15/243 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+ GQ V+ Q F+ GD + +A+R+ E+GA + D+ + G + Sbjct: 1 MQLYPAIDLMSGQAVRLKQGDFQQQTFFGDALTIARRFKEDGATAIHLIDLDGAKAGEPL 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 S ++ + + + GG++++E + G D+I I + AL D L+ ++ +R G Sbjct: 61 HLSLIADIKKETGLFVEAGGGVRNIETVEAYVGAGIDRILIGTVALEDEALLEQMIERAG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V +D A+ G + + W ++ + ++G + +++ Sbjct: 121 -DKLAVALD----AKDGIVQTRGW------LEASDWTLERAIEHLIQKGIKTFLYTDISR 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG+ G D++ L + + V LIASGG T+E + ++ +DGA+ +++ Sbjct: 170 DGMMQGPDVDGL-DLLKRDGVELIASGGVTTVED-VARLKEIGMDGAVIGRALLDGSLSL 227 Query: 242 GEL 244 E+ Sbjct: 228 KEV 230 >UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. BL107 RepID=Q062W6_9SYNE Length = 255 Score = 202 bits (515), Expect = 8e-51, Method: Composition-based stats. Identities = 73/261 (27%), Positives = 121/261 (46%), Gaps = 11/261 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYA----EEGADELVFYDITASS 56 M KR+I L + G FR + IG++ L Y DELV D++ Sbjct: 1 MAKKRLIFTLLYQKGGFYLSRNFRLQK-IGNLSWLKINYNFYSVACAIDELVILDVSREK 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 R V+ V + +P + G I SL+DA ++ GADK+ IN+ +P L+ L Sbjct: 60 PDRQEFCEVVNEVCQNCFMPLALGGHINSLDDAKMLIYNGADKLIINTALHENPNLVREL 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 +G QCI+ +D E G + V G + R + ++ + + G GE+ L Sbjct: 120 IAIYGSQCIIGSVDYKI--EEGSFIVYTNQGKKRLDRPLN----EHIERLGEMGVGELYL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 N +++DG GY E LK++ H+P+I +GGAG H E+ VD A++ + Sbjct: 174 NSIDRDGTGQGYVSEVLKQLDSASHLPIIQAGGAGNKHHLQESLECRGVDAVATANLLNF 233 Query: 237 QIINIGELKAYLATQGVEIRI 257 + + + +L +G+ + I Sbjct: 234 VGDGLPKAREFLINKGISMAI 254 >UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB3_9BACT Length = 239 Score = 202 bits (515), Expect = 9e-51, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 102/249 (40%), Gaps = 18/249 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 M I P +D+ +VV+ + D V A +AE GA + D+ + Sbjct: 1 MKKIEIYPAIDLYSRKVVRLTGGDFEKIKEYGDDPVETALSFAEAGARWIHLIDLEGAEK 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G V + +VA +P GG+++ ED A LS GA ++ + S L Sbjct: 61 GSPVHLKELEKVAASTGLPVQYGGGLRTEEDVALALSSGAKRVYLGSLLFKGSP--RTLW 118 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 RFG IV +D N T VTQ + + E+ + G ++ Sbjct: 119 KRFGN-SIVPSVDVK----------NGTVALSGWTEVTQLPPEEAITELLRIGYSTFLVT 167 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +++DG +G DL+ +++++ ++A+GG + + + V GA+ ++ Sbjct: 168 SVSRDGTASGPDLKLYERLKK-TDGRILAAGGIRDKKDLAD-LAEIGVSGAVLGKSIYEG 225 Query: 238 IINIGELKA 246 +++ E Sbjct: 226 TVDLREAVE 234 Score = 40.8 bits (95), Expect = 0.039, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 34/116 (29%), Gaps = 3/116 (2%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSW 65 I+P +DV++G V G + ++ D Sbjct: 125 IVPSVDVKNGTVALS--GWTEVTQLPPEEAITELLRIGYSTFLVTSVSRDGTASGPDLKL 182 Query: 66 VSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 R+ + D AGGI+ +D A + G + + + FG Sbjct: 183 YERL-KKTDGRILAAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAVEEFG 237 >UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8LDL7_THAPS Length = 570 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 90/325 (27%), Positives = 139/325 (42%), Gaps = 69/325 (21%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFR--------------NHEIIGDIVPLAKRYAEE 42 L KR++ LDVR D V KG Q+ +G V LA RY +E Sbjct: 244 LVKRVVVALDVRSNDHGDLVVTKGDQYDVRENEKEGVQEGRGGVRNLGKPVSLASRYYKE 303 Query: 43 GADELVFYDITASSDGRVVDKSWV---SRVAEVIDIPFCVAGGIKSLED----------- 88 GADE+ F +IT+ G + D + ++ I +P V GGI+S ED Sbjct: 304 GADEIAFLNITSFRSGVIEDMPMLQVLEEASKEIFVPLTVGGGIRSYEDPGTGKVYSALE 363 Query: 89 -AAKILSFGADKISINSPAL-------------ADPTLITRLADRFGVQCIVVGIDTWY- 133 A++ GADK+SI S ++ T I ++ +GVQ +V+ ID Sbjct: 364 VASRYFRAGADKVSIGSDSVHAAEEYIASGNTKTGQTSIETISHVYGVQAVVISIDPKRV 423 Query: 134 ---------------------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 G+ + + + + + GAG Sbjct: 424 YVTSPDAADSKHTVVTLDDSQKGPNGEQYCWYQCTVKGGREARDICAVSVAKAAEALGAG 483 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 EI+LN ++ DG NG+D +K V + +P+IAS GAG HF + F + V ALAA Sbjct: 484 EIMLNCIDMDGQCNGFDHALMKAVSDAVTIPVIASSGAGKESHFSDVFSETSVQAALAAG 543 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 +FH++ + I ++K ++ G+ RI Sbjct: 544 MFHRKEVEIADVKKHMEKMGIRARI 568 >UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=HIS4_BUCBP Length = 241 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 50/243 (20%), Positives = 101/243 (41%), Gaps = 10/243 (4%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ +G +V+ Q +I +A +Y +GA + D+ + Sbjct: 2 IIPSIDLIEGNIVRLYQGNYDTKTFYQNNIYDIALKYYNQGAKIVHLVDLDGALCPNNKQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S + + + V GGI+S +D +L GA ++ I S A+ + T + + FG Sbjct: 62 TSLIKNLLNYFNFHIQVGGGIRSYKDVETLLLNGAKRVVIGSSAINNITEVEKWLLEFGY 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+ +D + Y G ++R+ V+ L+ G ++ + +D Sbjct: 122 KSIVLALDVYV--RNNGYKEVVINGWKNRSNVSLESVLE---RFSTLGIKYVLCTDVKKD 176 Query: 183 GVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + K + ++ +V SGG GT+ + A + + + + + ++ Sbjct: 177 GTCLGPNFTLYKNISKLFKNVCFQLSGGIGTISDVISA-KKSGIKDIIIGRALLENKFSL 235 Query: 242 GEL 244 E Sbjct: 236 LEA 238 >UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_ANADF Length = 238 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 104/239 (43%), Gaps = 15/239 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ G+ V+ + A+ +A GA L D+ + G V+ Sbjct: 3 VIPAIDLMGGEAVRLEKGDFATKTVYARHPAEKAEEFARAGATLLHVVDLDGAKAGWPVN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V + EV I + GG++SL D K+L+ G + + + A+ L+ + RF Sbjct: 63 LDAVRAICEVPGIEVELGGGLRSLPDIEKVLALGVRYVVLGTAAVERLGLVEQACQRFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q + DA G+ + + T +D ++V+ G G + + +D Sbjct: 123 Q-----VRAGIDARNGEVKIAGW------LEGTGLAAVDVARKVKGAGVGLVEYTDVARD 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G D +++ +P++ASGG +++ + A R A + G + +++ I++ Sbjct: 172 GMFTGVDAAGAARIQAEAGIPVVASGGVASLDD-VTACRAAGLAGVIVGKALYERRIDL 229 >UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U8M5_HYDS0 Length = 234 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 54/247 (21%), Positives = 104/247 (42%), Gaps = 17/247 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGV--QFRNHEII-GDIVPLAKRYAEEGADELVFYDITASSDG 58 + IIP +D++DG VV+ +F N ++ + + K + + G + D+ + G Sbjct: 1 MKDFIIPAIDIKDGAVVRLKEGKFENVKVYRQNPIDQFKLFVDLGFTRIHIVDLDGAKVG 60 Query: 59 RVVDKSWVSR-VAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + + + + D + GGI+SLE A + GAD I + + A+ D RL Sbjct: 61 IPKNLKLLEDMLKQKNDAKVEIGGGIRSLETAKALFEIGADYIIVGTLAVKDKEEFIRLL 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + + I++ +D A+ GK + + + D + + Sbjct: 121 ELY-KDRIILSVD----AKNGKVAIGGW------EEESSISPCDMARIYDNYPIESYLYT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +N DG G D+ K ++ P+IASGG ++E ++ V+G + ++ Sbjct: 170 NINIDGTLTGVDINPYKDFKKCTTKPIIASGGVASLEDVIKLKTV--VNGVVVGKAIYEN 227 Query: 238 IINIGEL 244 I+I L Sbjct: 228 KIDIYNL 234 >UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase subunit n=1 Tax=Erythrobacter litoralis HTCC2594 RepID=Q2N6D2_ERYLH Length = 264 Score = 200 bits (509), Expect = 5e-50, Method: Composition-based stats. Identities = 67/220 (30%), Positives = 110/220 (50%), Gaps = 6/220 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP L + VK QF+ IGDIV A+ + + ADEL+ DI Sbjct: 1 MRRLRIIPVLLLDGTSAVKTHQFKPARYIGDIVNAAQIFNSKMADELIVVDI-GYHQDNP 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + +AE +P GGI S+++AA + G +K+SIN+ + L+ A +F Sbjct: 60 SRPEVIRHLAEECFMPLAFGGGISSVDEAAALFKDGIEKVSINTAFVEGGALVEEAARQF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V ID +A G Y V TR + ++ + + +GAGEI++ ++ Sbjct: 120 GSQSVVASIDARREA-DGSYQVYS----RGGTRALGIDPVEMARRAEAQGAGEILIQSID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 +DG+R GYD ++ + + +P++A GGA T++ + Sbjct: 175 RDGMRKGYDRNLVRSIVDATTLPVVALGGADTVDDLAQVI 214 >UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=2 Tax=Pedobacter RepID=C6Y3G6_PEDHD Length = 249 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 111/255 (43%), Gaps = 21/255 (8%) Query: 6 IIPCLDVRDGQVVKGVQFR-NHEIIGD--IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ DG+VV+ + N + + D I + + Y G + + D+ + G + Sbjct: 3 IIPAIDILDGKVVRLTEGDYNQKTVYDVSIAEMIETYRSNGTEFIHIIDLNGAK-GDFSN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + V + D+ GGI++++ +L G ++ + + A+ +P + L+ G Sbjct: 62 QKALFEVIKKTDMRVQYGGGIRTIKQVTDLLDAGIHRVIVGTQAITNPDFLQELSKEVGK 121 Query: 123 Q-----CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + IV+ ID +++ + + +D+V + + G + Sbjct: 122 KYDYANRIVIAIDV----------LDEVIKYSGWMESSPIKLMDYVDKCLQLGFFRFLCT 171 Query: 178 MMNQDGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +N+DG G +E KK+ E + LIASGG +M+ E D+ + ++ Sbjct: 172 DINKDGKLGGAAVELYKKLLEHSPFIKLIASGGVSSMKDIEE-LDKYDIRSVVVGKAIYE 230 Query: 237 QIINIGELKAYLATQ 251 I I ++K + Q Sbjct: 231 NRITIDQIKEWNLKQ 245 >UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=cellular organisms RepID=HIS4_THEON Length = 229 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 105/247 (42%), Gaps = 22/247 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI--IGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 RI P +D+ G+ V+ + + ++ GD V +A R+ E D++ D+ + G+ Sbjct: 1 MRIYPAIDLMGGKAVRLYRGQKEKVKVYGDPVEIASRFTEL-VDKIHVVDLDGAFTGKPQ 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V + E + V GG +S E AK GA+ + I + A D + ++ D F Sbjct: 60 NLDVVKEIIEETGLKVQVGGGFRSYESIAKAYEIGAENVIIGTKAF-DLEFLEKITDNFD 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 GI DA GK V + + S E + ++E R + + + Sbjct: 119 ------GITVSLDARGGKIAVKGWLEESSLKVG---EAYEMLREYVDR----FIYTSIER 165 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G +E +++ + I +GG +++ L+ R GA+ ++ +++ Sbjct: 166 DGTLTG--IESIERFWK--DEEFIYAGGVSSVDDVLK-LRRVGFSGAIVGKALYESEVSL 220 Query: 242 GELKAYL 248 EL L Sbjct: 221 KELLEVL 227 >UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID=Q1N2Y7_9GAMM Length = 223 Score = 197 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 67/229 (29%), Positives = 121/229 (52%), Gaps = 8/229 (3%) Query: 29 IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED 88 +GD + K ++ ADE+V DI A+ R ++ + R++ +P + GG+ +LED Sbjct: 2 VGDAITNVKVFSSRKADEMVIVDIEATEKKR-INLPLLKRLSSHCIMPLTIGGGVTTLED 60 Query: 89 AAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGD 148 A + S GADK+ +NS P ++T ++ +FG Q +V +D + Sbjct: 61 AEDLFSVGADKVLVNSAFYNRPEILTDISSKFGRQAVVFSLDVMKKSNEY------VPVS 114 Query: 149 ESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASG 208 ++ + W + V+ + GAGEI+LN ++ DG+ G+DL K+V ++ VP++ +G Sbjct: 115 KNGSVKQSWTLRETVERAIEYGAGEIILNSVDCDGMMQGFDLNLCKQVSDISSVPVVIAG 174 Query: 209 GAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 G GT E + A ++ D A S+F+ +I +K Y+ G+E+R+ Sbjct: 175 GCGTKEDCVLAV-NSGADAVAAGSIFYWVGESILTIKDYMNKNGLEVRL 222 >UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW5_HODCD Length = 241 Score = 196 bits (500), Expect = 5e-49, Method: Composition-based stats. Identities = 44/251 (17%), Positives = 102/251 (40%), Gaps = 16/251 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRN---HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 R + +DV++G+ V+ + + + +++ + D + D+ + G Sbjct: 1 MRFLASIDVKNGECVRLCRGQMADCRVYASSPLEAVRKFNLQCCDLVHIVDLDGAVCGSP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + A + V GG+++L DA L GA K+ + + A+AD + ++ + Sbjct: 61 QNWRSILEAARQLKGCVQVGGGVRTLADAKLYLEGGASKVVLGTSAIADMEFVCHVSWLY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + VG+DT+ + + T V+ V +++ ++ +N Sbjct: 121 PG-RVCVGVDTFGEL----------VATDGWTAVSCVRCDQLVPKLEAARVSCLIWTDIN 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG G + + L +V VP+I SGG T ++ + G + +++ Sbjct: 170 RDGTLQGVNFDALDRVLAASAVPVIVSGGVATALDLIKLHNLYADKLAGVICGKALYERT 229 Query: 239 INIGELKAYLA 249 + ++ L+ Sbjct: 230 LTARFARSILS 240 >UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase HisF n=1 Tax=Sphingobacterium spiritivorum ATCC 33300 RepID=C2G0W0_9SPHI Length = 263 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 79/256 (30%), Positives = 127/256 (49%), Gaps = 11/256 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGA----DELVFYDITASS 56 ML KR+I L DG ++ FR ++ GDI L K Y DELV +++ S Sbjct: 1 MLRKRVIFTLLYCDGFFMQSRNFRLQKV-GDINWLEKFYKFNKIAFSLDELVILNVSRKS 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + VSR+ E +P V GGI+SLEDA + GADKI +N+ +DP L+ + Sbjct: 60 KNQEEFGRTVSRLVEGTYMPVAVGGGIRSLEDAEMLFKSGADKIVLNTSLSSDPDLVKLI 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 ++G Q +V ID E+ + + E+ + +++ ++ GE+ L Sbjct: 120 VQKYGSQSVVASIDYLKKGESSEIFI------ENGSLNINEGFENYLSHLKDLNVGEVYL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 N M +DG GYD +K V+ + +VPLI +GGAG H EA +++ A A++F+ Sbjct: 174 NSMERDGTGFGYDFSLVKLVKSILNVPLIIAGGAGNEGHLKEALLHSEISAAATANLFNF 233 Query: 237 QIINIGELKAYLATQG 252 + + + +L G Sbjct: 234 IGDGLPKARFFLINSG 249 >UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alphaproteobacteria RepID=HIS4_MARMM Length = 244 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 47/250 (18%), Positives = 103/250 (41%), Gaps = 12/250 (4%) Query: 6 IIPCLDVRDGQVVKGVQ--FRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+ DG+VV+ + F GD + +A+++ E GA + D++ + DG Sbjct: 3 LYPAIDLLDGRVVRLHKGAFDAVTDYGDDPMRVAEQFGEAGAVWVHIVDLSGARDGARRQ 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + E + GG++S ED +L+ G +++ I S A+ D + +G Sbjct: 63 GALIRSLCE-TGLRVQTGGGVRSAEDIEDLLAAGVERVIIGSLAVTDTNRVAGWLQNYGG 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I + +D + + + T + D + + G ++ + +D Sbjct: 122 DRITLALDVRQIGGQYRPALKGW------TDMADTTLDDVISAYEGTGLAHALVTDIGRD 175 Query: 183 GVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G +G ++ K++ + ++ ASGG +++ A + ++ + Sbjct: 176 GDLSGPNIALYKRLATDYPNIDWQASGGVSSLDDLRAARAAGAAGA-ITGKALYEGRFTV 234 Query: 242 GELKAYLATQ 251 GE A L Sbjct: 235 GEAIACLRDA 244 >UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PRW0_MALGO Length = 576 Score = 191 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 97/376 (25%), Positives = 153/376 (40%), Gaps = 119/376 (31%) Query: 1 MLAKRIIPCLDVR---DGQVV--KGVQFR-------------------------NHEIIG 30 M +RI+ CLDVR DG +V KG + +G Sbjct: 200 MPTRRIVACLDVRSNDDGDLVVTKGESYNVRERQPAEGQAKSTADGTIRSGGKAQVRNMG 259 Query: 31 DIVPLAKRYAEEGADELVFYDITASSD---GRVVDKSWVSRVAEVIDIPFCVAGGIKS-- 85 V LA+RY EEGADE+ F +IT+ + G S ++ A I +P V GGI+ Sbjct: 260 KPVELAQRYYEEGADEIAFLNITSFRNWALGDQPMLSLLNVAAATIFVPLTVGGGIRDFT 319 Query: 86 ---------LEDAAKILSFGADKISINSPAL---------------------ADPTL--- 112 LE A GADK+SI S A+ A P + Sbjct: 320 DPDGTFHPALEVAHAYFRAGADKVSIGSEAVYAVEQLLQRATELGDCTGDPCAAPAMALR 379 Query: 113 ----ITRLADRFGVQCIVVGIDTWY----------------------DAETGKYHVNQYT 146 I ++A ++GVQ +VV +D DA T + + Sbjct: 380 GDTGIEQIAHKYGVQAVVVSVDPKRVYLSDQEIDGLSDEHSSGDGPVDARTHPHASSIVC 439 Query: 147 GDESRTRVTQ-------------------WETLDWVQEVQKRGAGEIVLNMMNQDGVRNG 187 G + R + + + V++ GAGE+++N +++DG G Sbjct: 440 GQDERPETAGQSARWWYMCTVKGGRESRDIDVVQLARGVERLGAGELLINSIDRDGSYAG 499 Query: 188 YDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF------RDADVDGALAASVFHKQIINI 241 +D + + VR ++P+IAS GAG +HF + R A ++ ALAA +FH++ ++I Sbjct: 500 FDEKLIDLVRGCVNIPVIASSGAGCADHFCDVLASRPAARGAPIEAALAAGIFHRREVSI 559 Query: 242 GELKAYLATQGVEIRI 257 ++K A G +R+ Sbjct: 560 MDVKKRCADAGYPVRM 575 >UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Archaeoglobaceae RepID=HIS4_ARCFU Length = 238 Score = 189 bits (482), Expect = 7e-47, Method: Composition-based stats. Identities = 47/245 (19%), Positives = 110/245 (44%), Gaps = 18/245 (7%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+IP +D++DG+VV+ Q + E+ + + +AK++ E GA L D++ + GR+ Sbjct: 3 RVIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRLR 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++ +A++ + V GGI+ A ++ G D++ + A+ + A ++ Sbjct: 63 HEEIIAEIAKMAE--VQVGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKWK 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +V D++ G+ V + V + + + + ++ Sbjct: 121 GRVMVA-----IDSKKGRVAVKGWK------EVVELTPVQLAELYDDLDV-SFLYTNIDV 168 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 +G+ +G + E++++V + P+ +GG ++E A R G + S + + + Sbjct: 169 EGLVSGIERERIEEVVKSLRNPVYVAGGISSIEDIRFAKR-VGAAGVVIGSALYTKKLKF 227 Query: 242 GELKA 246 E Sbjct: 228 EEAIK 232 Score = 57.0 bits (137), Expect = 7e-07, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 44/117 (37%), Gaps = 5/117 (4%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVF-YDITASSDGRVV 61 R++ +D + G+V V+ + V LA+ Y + L D+ G + Sbjct: 120 KGRVMVAIDSKKGRVA--VKGWKEVVELTPVQLAELYDDLDVSFLYTNIDVEGLVSG--I 175 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 ++ + V + + P VAGGI S+ED GA + I S Sbjct: 176 ERERIEEVVKSLRNPVYVAGGISSIEDIRFAKRVGAAGVVIGSALYTKKLKFEEAIK 232 >UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=Lactobacillus fermentum RepID=C0WXE8_LACFE Length = 188 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 58/195 (29%), Positives = 102/195 (52%), Gaps = 7/195 (3%) Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V +++ + +P V ++++ + +L GADK+ I++ ++ P I ++A FG Sbjct: 1 MLDMVEAISQQVFMPMTVVCNVRTVVEVRNLLLAGADKVGISTRSIMAPDFIPKVAQVFG 60 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q IV +D D T + V T+ + +W V + G GE+++N M++ Sbjct: 61 NQSIVAILDYHVDPRTNRKIVCT-------PGNTELDAYEWTLRVVELGVGELLVNSMDR 113 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG NG+D + + +P++ASGGAG+ F E F ++ V GA+AAS FH + I Sbjct: 114 DGTENGFDTAFYRDLTTTLTIPVVASGGAGSTVDFEEVFVNSGVTGAMAASAFHLDQMTI 173 Query: 242 GELKAYLATQGVEIR 256 E+K L +G+ +R Sbjct: 174 SEVKETLLEKGILVR 188 >UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ6_9ACTN Length = 247 Score = 187 bits (477), Expect = 2e-46, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 112/255 (43%), Gaps = 20/255 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASS----DG 58 + P +D+ G+VV+ + D V +A+ +AE+GA + D++++ D Sbjct: 3 LFPAIDLIGGKVVRLERGDRSRCKVYSDDPVAVARSFAEQGASWVHVVDLSSAFGEDEDT 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + + + V + V GG++SL ++ +GA +I++ + + +P A Sbjct: 63 CAANSAAIKAICGVDGLSVDVGGGVRSLARIDELAGYGARRIALGTVLVTEPGFAEVAAQ 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG + +V I A G+ VN + D V ++ + G +V Sbjct: 123 GFG-ELLVADI----AARDGQVKVNGW------RDGAGVALDDAVAQLSELGFKHLVYTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGALAASVFHK 236 + +DG++ G D+ + V EV P++ASGG ++ L A + ++GA+ ++ Sbjct: 172 IARDGMQTGIDVAAYRHVAEVAGFPVVASGGISALDDIRALAAVGEGAIEGAITGRALYE 231 Query: 237 QIINIGELKAYLATQ 251 + + A + Sbjct: 232 GNFTLAQALAAARGE 246 >UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=4 Tax=Vibrio RepID=A6Y2G9_VIBCH Length = 262 Score = 187 bits (476), Expect = 3e-46, Method: Composition-based stats. Identities = 48/261 (18%), Positives = 105/261 (40%), Gaps = 20/261 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQF--------RNHEIIGDIVPLAKRYAEEGADELVFYDI 52 M ++ P +D+ G+ + +G++ +A+ + + GA + D+ Sbjct: 1 MEEFKLYPSIDIVGGKALTSRSAIDITLGITEEKTYLGEVFEVAELHFQSGAKWIHIVDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVID--IPFCVAGGIKSLEDAAKILSFGADKISINSPALADP 110 A+ G ++ + + + + V GGI+S E + + G +++I+S P Sbjct: 61 DAA-SGVGSNQRLIMDLVKHFSEKVQTQVCGGIRSNEILEQYILAGCSRVNISSMIFDKP 119 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 L +L ++G + I + +D + K + + W TLDW + G Sbjct: 120 KLCEKLLKKYG-EKIAIALDVKLVNQEYKLATRGWNTLQGNL----WTTLDW---LDNSG 171 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALA 230 VL +++ G N + L++V P+I+ GG +++ + ++GA+ Sbjct: 172 CQRYVLTDVDRGGSLNHPNFSLLEQVLTKTSTPIISGGGLCSLDDI-DRLYQIGIEGAVL 230 Query: 231 ASVFHKQIINIGELKAYLATQ 251 + H Q + Y+ Sbjct: 231 GQLIHTQQHQLKRFLQYVQQN 251 >UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVE8_9SPHI Length = 244 Score = 186 bits (472), Expect = 8e-46, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 109/250 (43%), Gaps = 13/250 (5%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP + + +G+ V+ + I + + +A+ + G L D+ + G + Sbjct: 4 VIPSIWLINGKCVRLKRGDFATEEAISNNPLEIAQGFESIGIKRLHLVDLDGARRGEPKN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A ++ GG+ + D K FGA ++I+S A P ++ +G Sbjct: 64 YHILEAIAGYTNLHVDFTGGVTTDGDVIKSFEFGAKTVTISSAAANYPERFSQFILSYGR 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + I + DT + K + + + T+ + D ++ RG + + + +D Sbjct: 124 EKINLAADT--NPADRKIKIRGW------LKKTEIDLYDHIEFFYDRGLKYLKCSDVTRD 175 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 GV G + E + + ++ + ASGG ++E F E + V+ A+ +++ ++ + Sbjct: 176 GVMVGPNFELYADLVKKFPNLNIAASGGVRSIEDFKE-LKKLGVNAAVFGRAYYEGMLKL 234 Query: 242 GELKAYLATQ 251 +L +++ + Sbjct: 235 EDLADFISEK 244 >UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Synechococcus sp. WH 8102 RepID=HIS62_SYNPX Length = 269 Score = 184 bits (468), Expect = 2e-45, Method: Composition-based stats. Identities = 63/240 (26%), Positives = 104/240 (43%), Gaps = 11/240 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYA----EEGADELVFYDITASS 56 M KRII L DG F+ IGD L + Y DEL+ DI+ S Sbjct: 1 MSKKRIIFVLLYCDGFFCLSRNFKLQR-IGDFRWLQRNYNFNYSATFIDELIILDISRKS 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + + ++E I +P GGI+S EDA + GADK+ +N+ + P + ++ Sbjct: 60 RDINKFATLLYNLSENIFVPITAGGGIRSFEDAKVLFENGADKVCLNTSLIQCPHVSEKI 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 + +G Q +V ID +D K+ ++ + Q+ + + + EI+L Sbjct: 120 SSVYGQQSLVASIDFKHDHGDFKFFID------NGLIEVQYNIQELISFLDPLPFCEILL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +++DG G+DL R+ P+I GGAG +H +E D A + + Sbjct: 174 QSVDRDGTGTGFDLTLANTFRDQLSKPIILLGGAGHSDHLVEGLLHQSTDAVATAHLLNF 233 >UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HIS4_RUBXD Length = 243 Score = 184 bits (468), Expect = 3e-45, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 101/250 (40%), Gaps = 19/250 (7%) Query: 6 IIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D++ G+ V+ Q R D V A+ + GA L D+ + +GR V Sbjct: 9 VFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPVQ 68 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +A +P V GGI++LED GA ++ + + A+AD R + G Sbjct: 69 LALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELGA 128 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +VV +D R + + E+ G ++ +++D Sbjct: 129 D-LVVAVDAR----------EGVVATHGWQRQSGVGAAELAGELAAEGVRAVLFTDISRD 177 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G LE+ +V + +P IASGG R V GA+ + ++ + Sbjct: 178 GTGEGAALERTAEVAGI--IPTIASGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLE 235 Query: 243 ELKAYLATQG 252 EL LA G Sbjct: 236 EL---LAAAG 242 Score = 44.3 bits (104), Expect = 0.004, Method: Composition-based stats. Identities = 29/125 (23%), Positives = 51/125 (40%), Gaps = 5/125 (4%) Query: 133 YDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNG--YDL 190 D + G+ V GD R RV + + +E ++RGA + + ++ DG R G L Sbjct: 13 IDLKGGR-CVRLRQGDFGRERVYDADPVGRAREWERRGARALHV--VDLDGAREGRPVQL 69 Query: 191 EQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLAT 250 ++++ VPL GG T+E A R + + + + L+ A Sbjct: 70 ALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELGAD 129 Query: 251 QGVEI 255 V + Sbjct: 130 LVVAV 134 >UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8V9_IGNH4 Length = 235 Score = 183 bits (466), Expect = 4e-45, Method: Composition-based stats. Identities = 59/247 (23%), Positives = 108/247 (43%), Gaps = 19/247 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+ P +DV +G+ VK V+ +GD V A+ +A EGA L D+ + G+ + Sbjct: 1 MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPI 60 Query: 62 DKSWVSRV---AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + +++V A+ + VAGG++ +E + AD I S A DP + ++ Sbjct: 61 NVEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPK--ADAFVIGSRAHKDPEFLEVASE 118 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G ++V ID + GK V + + V E L+ + + R + Sbjct: 119 AVGADKVIVAID----LKGGKVSVEGW---KEEIPVGLKEALE---KFKGRSFRGFLYTY 168 Query: 179 MNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 ++ +G G D+ +K + RE L +GG G+ EH ++ A D + + Sbjct: 169 VDTEGTMEGPDVSGVKYIRREYPDKLLEYAGGVGSPEH-VKLLESAGADVVVLGMALYSG 227 Query: 238 IINIGEL 244 + + +L Sbjct: 228 KLRLKDL 234 >UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Dictyoglomus RepID=HIS4_DICT6 Length = 242 Score = 182 bits (464), Expect = 8e-45, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 104/250 (41%), Gaps = 20/250 (8%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ +VV+ + +I+ + + LAK + E+GA L D+ ++ D Sbjct: 3 IIPAIDIYKHKVVRMETGKKEKIVLEFNNPLDLAKYWEEKGAKALHLIDLQSAIDANDES 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 KS V + + IP V GG +S E + +S+G ++ ++S + + L ++ Sbjct: 63 KSIVRDIVRSVSIPVEVGGGYRSREKIEEAISWGVWRVIVSSILGMELDYLLDLFSKYEN 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I+ ID + GK + + + +++ E++ +++D Sbjct: 123 -KIIPSIDWY----DGKVGIKGWQDFIEWRDIK--------RKIDLLKVREVIFTDISRD 169 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF----RDADVDGALAASVFHKQI 238 G G +LE +K + + +GG ++E ++ + G + + Sbjct: 170 GTLKGVNLENIKNFLSLHDYDVWIAGGISSIEDVIKIKDLSENTGRIKGIIIGRALLEGK 229 Query: 239 INIGELKAYL 248 IN E K + Sbjct: 230 INWEEAKKII 239 >UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZQ4_9SPHI Length = 250 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 43/255 (16%), Positives = 106/255 (41%), Gaps = 22/255 (8%) Query: 6 IIPCLDVRDGQVVKGVQFR-NHEIIGDIV--PLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +DV D +VV+ + + DI RY G + + D+ + G + Sbjct: 3 IIPAIDVLDKKVVRLREGNYDDVTTYDISLEEQIDRYHANGTELVHIIDLNGAK-GDFSN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD---- 118 + ++ + ++ GG++S+E +++ G ++ + + A+ +P + L+ Sbjct: 62 QEYLFNIIRKTEMKIQYGGGVRSIEKVKELIDAGVFRVIVGTQAITNPEFLEELSTLNEG 121 Query: 119 --RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 ++ IV+ ID +++ + + ++++ + G + Sbjct: 122 KIKY-ADHIVIAIDV----------LDEVIKYSGWLESSPIKLIEYIDKCLALGFYRFLC 170 Query: 177 NMMNQDGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 +++DG G +E KK+ + + LI SGG +M+ + ++ + + Sbjct: 171 TDISKDGKLGGAGVELYKKLLDHSPIIKLIGSGGISSMDDIRKLQELGRMESCVVGKAIY 230 Query: 236 KQIINIGELKAYLAT 250 + I+I E++ + Sbjct: 231 ENRISIEEIQDWNLK 245 >UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=HIS4_THENN Length = 248 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 54/263 (20%), Positives = 110/263 (41%), Gaps = 24/263 (9%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSD 57 ML +IP +D+ +VV+ V+ + I D + L ++ EEG + D++ + + Sbjct: 1 ML---VIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIE 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + + +++ D + GGI+ LE A K+L G + ++S L DP+ + +L Sbjct: 58 ESDENLPVLEKLSSYAD-HIQIGGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKL- 115 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 GV + D GK + ++ + + V +++ G EIV Sbjct: 116 KEIGVNPV-----FSLDTREGKVAFKGWLDEK------DIDPVFLVNRLKEFGLEEIVHT 164 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-----DADVDGALAAS 232 + +DG +D +++ V +IA+GG + EA + + G + Sbjct: 165 EIEKDGTLKEHDFSLTERIALETGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGR 224 Query: 233 VFHKQIINIGELKAYLATQGVEI 255 F + + + +K Y + + Sbjct: 225 AFLEGTLTVEVMKRYACQENNSV 247 >UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. AS9601 RepID=A2BSD9_PROMS Length = 254 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 121/236 (51%), Gaps = 6/236 (2%) Query: 1 MLA-KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 M R+I L + +++K +F+N++ +GD + + + + + DE+ Sbjct: 1 MKKHPRVILSLIIDSKRMIKRSKFKNYKYLGDPLNIIRIFNSKRVDEISIISCENYEKKD 60 Query: 60 -VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 +D ++ +++ P +GG++SLEDA K+ S G +KI I + +P +I ++A+ Sbjct: 61 INIDFEFLEKISGEAFCPLTYSGGVRSLEDADKLFSIGFEKIGIRNLLHTNPEVIKQIAE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 ++G Q +V+ ID E + YT S + T+ L++++ + GAGE+VL Sbjct: 121 KYGSQSVVIFIDYK---ELNNNEIEIYTSYNSFFKSTKSSILEFIKNAESYGAGEVVLQS 177 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 + ++G G DL+ +K++ +P+I+S G + +AF DG +A+ F Sbjct: 178 ILREGQSKGLDLDIIKEITNKTILPIISSCGMRDLSDARKAF-SLGADGVMASKFF 232 >UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit HisF2 n=3 Tax=Rhizobium RepID=Q7WYR2_RHIL3 Length = 251 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 11/220 (5%) Query: 2 LAKRIIPCLDVRDGQ-VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + KR+IP L V + +VK ++F +GD + + + E+ DE+ DI A+ GR Sbjct: 1 MRKRLIPVLLVDQKRRLVKTIEFGERTYVGDPFNVVRLFNEKEVDEICILDIDATRTGRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D +V +A +P GGI L+ ++ G +K + A + L+ +A Sbjct: 61 PDLGFVRELATECFMPLAYGGGITELKQCEELNRSGVEKFVLGQGA-RNSQLVGAIAADM 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V +D D +G E +++ +Q G GEI+L Sbjct: 120 GSQALVACVDV--DGRGAAASCYASSGAR-------QEPIEFCLRLQDAGVGEIILQSKT 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 DG RNGYDLE ++ + +P++A GGAG + H +E Sbjct: 171 LDGTRNGYDLELIQSITRKLSIPVVALGGAGDVAHLMEGL 210 >UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B860_THEAS Length = 232 Score = 178 bits (453), Expect = 1e-43, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 92/244 (37%), Gaps = 18/244 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+ G+VV+ R +A +A+ G D+ + GR Sbjct: 1 MEIYPAVDLYGGKVVRLTGGRFQDATVYPTSPGEMALLFAQAGVRWAHVVDLEGAKTGRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V + A + GGI+S++ LS GA ++ + S + F Sbjct: 61 VHLWALEAFAGA-GLKVQFGGGIRSIQSVRDALSAGATRVMMGSALFDRSVDVVEAHRLF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G I D + V + T+ T ++ + + G ++ + Sbjct: 120 GP-----AILPAVDHRGWRVSVKGW------TQGTDIPVDRALENLSRVGFSLFLVTDGD 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G DLE +K+ + IA+GG G + H R+A GA+ ++ I+ Sbjct: 169 RDGTLSGPDLEGYRKICARYGI--IAAGGIGELGHL-RGLRNAGAAGAVLGKALYEGAIS 225 Query: 241 IGEL 244 I E Sbjct: 226 IEEA 229 >UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3E3_9BURK Length = 251 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 110/254 (43%), Gaps = 23/254 (9%) Query: 6 IIPCLDVRDGQVVK---GVQFRNHEIIGDIVPLAKRYAEEGADELVFY--DITASSDGRV 60 IIP + ++DG+ V G + + D + LAK++A+ GAD L + AS+ Sbjct: 3 IIPSIYIQDGKCVHVSYGDKTSSSPFEIDPLDLAKKWADLGADRLHIVQLGLNASTQNAT 62 Query: 61 ---VDKSWVSRVAEVID--IPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + +S++ E + +P +AGGIK++ L G D + + S + DP + Sbjct: 63 SLSKNNEVLSKLIEEVSHYLPLQIAGGIKTMASIESYLDMGFDFVVVGSAGVKDPHFMND 122 Query: 116 LADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIV 175 F Q +++G+D A GK + + ++VT+++ + Q + G I+ Sbjct: 123 ACSAFNGQ-VILGLD----ARDGKVVTDSW------SKVTKFDAVTIAQRLTDEGIDSII 171 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME--HFLEAFRDADVDGALAASV 233 M DG +LE + VP++A G G + H ++ D VDG + Sbjct: 172 YTDMGPDGNMTEVNLEATLNFAKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDGIILGKS 231 Query: 234 FHKQIINIGELKAY 247 + ++ E Sbjct: 232 LDLGVYSLQEAIDI 245 Score = 43.9 bits (103), Expect = 0.005, Method: Composition-based stats. Identities = 24/102 (23%), Positives = 45/102 (44%), Gaps = 5/102 (4%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 ++I LD RDG+VV + D V +A+R +EG D +++ D+ + V+ Sbjct: 130 QVILGLDARDGKVV--TDSWSKVTKFDAVTIAQRLTDEGIDSIIYTDMGPDGNMTEVNLE 187 Query: 65 WVSRVAEVIDIPFCVAGGI---KSLEDAAKILSFGADKISIN 103 A+ +D+P G + + ++ G D I + Sbjct: 188 ATLNFAKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDGIILG 229 >UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase n=2 Tax=Rothia mucilaginosa RepID=D2NNQ2_9MICC Length = 262 Score = 177 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 51/262 (19%), Positives = 106/262 (40%), Gaps = 23/262 (8%) Query: 6 IIPCLDVRDGQVVK--GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +D+ +G V+ G E D V A + + GA + D+ + GR + Sbjct: 8 LLPAVDISEGYAVRPVGGTLSGGEQRLDPVEAALTWVKAGARWIHLVDLDLAF-GRGTNT 66 Query: 64 SWVSRVAEVI-----------DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 ++ V + + V+GG+++ E + LS D++++ S ALAD + Sbjct: 67 EVLAEVVAAVRAENARMTGSAPVRIQVSGGVRNPESLERALSLNPDRVNVTSAALADSSW 126 Query: 113 ITRLADRF-GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + R+ + +G+D Y E G V + T + E L W ++ G Sbjct: 127 LEGTLARYADSDLLALGLDARYTPERGWVTVARGT---DWSGPGVAEALAW---LEGAGV 180 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGAL 229 ++ +++DG G E L V P++ASGG ++ ++ + ++G + Sbjct: 181 RRYIVTDVSKDGSLAGPGAELLDVVLAQTDRPVVASGGVASLADLVKLRSMVPSGLEGVV 240 Query: 230 AASVFHKQIINIGELKAYLATQ 251 + + + ++ Sbjct: 241 LGKALYVGNFSFEQALEIAGSR 262 >UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermotogaceae RepID=HIS4_THEP1 Length = 241 Score = 174 bits (441), Expect = 3e-42, Method: Composition-based stats. Identities = 54/257 (21%), Positives = 108/257 (42%), Gaps = 24/257 (9%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSD 57 ML ++P +D+ G+V + V+ + I D L K+ EEG + D++ + + Sbjct: 1 ML---VVPAIDLFRGKVARMVKGKKENTIFYEKDPAELVKKLIEEGFTLIHVVDLSKAIE 57 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 V + + R++E + + GGI+S + A ++ G + ++S L DP+ + L Sbjct: 58 NSVENFPVLERLSEFAE-HIQIGGGIRSFDYAERLRKLGYKRQIVSSKVLEDPSFLKFLK 116 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + I V D GK + +E + + ++ +++ G EIV Sbjct: 117 E------IDVEPVFSLDTRGGKVAFKGWLAEEE------IDPISLLKRLKEYGLEEIVHT 164 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-----DADVDGALAAS 232 + +DG +D +K+ V + A+GG + A R + + G + Sbjct: 165 EIEKDGTLQEHDFSLTRKIAIEAEVNVFAAGGISSENSLKTAQRVHRETNGLLKGVIVGR 224 Query: 233 VFHKQIINIGELKAYLA 249 F + I+ + +K Y Sbjct: 225 AFLEGILTVEVMKRYAR 241 >UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlorococcus marinus clone ASNC1363 RepID=Q1PLA2_PROMA Length = 268 Score = 173 bits (439), Expect = 6e-42, Method: Composition-based stats. Identities = 76/260 (29%), Positives = 122/260 (46%), Gaps = 16/260 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGA----DELVFYDITASSDG 58 KRII L + V FR + IGD+ L K Y + DEL+ D+T Sbjct: 4 KKRIIFTLLYNSNRFVLSRNFR-LQTIGDLDWLKKNYNFDNVAYHIDELLILDVTRGRKD 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 V++++E I +P + GGI SLE A GADK+SINS L D +L+T++ Sbjct: 63 SEEFCKVVTQISENIFVPLTIGGGINSLEKAKLFFKSGADKVSINSSLL-DESLVTQIVK 121 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQ-WETLDWVQEVQKRGAGEIVLN 177 +G QC+V ID + +Y+V G + + + + +E ++ GEI +N Sbjct: 122 NYGKQCLVGSIDVLK--KNEEYYVYSNNGTKLVSSLNKFFENKEFFNN-----IGEIYIN 174 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +NQDG NG D+ + V VP I SGG G + +AF+ ++ A + + Sbjct: 175 SINQDGTGNGLDISLAEFVSAKSEVPFIISGGVGKITDIKDAFKYDFINAVSTAHLLNFI 234 Query: 238 IINIGELKAYLATQGVEIRI 257 ++ + + G +R+ Sbjct: 235 GDSLKKTRLICDECG--VRL 252 >UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9303 RepID=A2CB98_PROM3 Length = 266 Score = 172 bits (436), Expect = 1e-41, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 13/260 (5%) Query: 1 MLAKRIIPCL--DVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEG----ADELVFYDITA 54 M KRII L D + + FR E+ GD L + Y DEL+ D++ Sbjct: 1 MPKKRIIFTLLYDSQSEHFLLSRNFRVQEV-GDYNWLKENYDFTNLSYYIDELLVIDVSR 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLIT 114 S + +++ +P GG+ SL+ A + GADK+ +N+ +P LI Sbjct: 60 KKRNSQRFCSMLKKLSSDCFLPIGAGGGLDSLDKAKMLFDSGADKLILNTSVYENPELIK 119 Query: 115 RLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEI 174 L +G Q I+ +D + E G + + + G + + + ++ + + GE+ Sbjct: 120 ALNKFYGQQAIIASVDIKKN-ELGIFDIYTHNGTKKASSLKDYQNI----ICKNEWIGEL 174 Query: 175 VLNMMNQDGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 LN M +DG GYD LK + P+I +GGAG H +E VD A + Sbjct: 175 YLNSMERDGTGQGYDFNMLKSFTNLNKKHPIILAGGAGKTSHIVEGLLTDGVDACATAHL 234 Query: 234 FHKQIINIGELKAYLATQGV 253 F+ + + + G+ Sbjct: 235 FNFIGDKLAKTRCIAKANGI 254 >UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Methanopyrus kandleri RepID=HIS4_METKA Length = 242 Score = 167 bits (424), Expect = 3e-40, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 110/252 (43%), Gaps = 14/252 (5%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDG 58 +A +IP +DV +G+ V+ V+ D V A +++E + D+ A+ G Sbjct: 1 MAFVVIPSVDVVEGKCVQLVEGDPERRTFESDDPVETAHQWSE-FFPWIHVVDVDAAR-G 58 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + R+ E +D V GGI+S E A +++ GAD++ + + A D +++ D Sbjct: 59 EGDNSDIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDDFSKIVD 118 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 C GI+ + + + H +G + VT + ++ EV + Sbjct: 119 V----CHDHGIEVFVALDVNENHEVLVSGWKEDAGVTLEDAIERFNEVAD----GYLTTA 170 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 ++ +G G D + ++K +P++ +GG +++ A ++A G + + + Sbjct: 171 VHVEGKEMGIDEKVVEKSTGATDLPVLYAGGIASIKDVKRA-KEAGAYGVVIGTALYHGD 229 Query: 239 INIGELKAYLAT 250 I+ L + Sbjct: 230 IDPVALLDLMEE 241 >UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=60 Tax=Staphylococcus RepID=HIS4_STAAB Length = 234 Score = 164 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 37/238 (15%), Positives = 87/238 (36%), Gaps = 16/238 (6%) Query: 6 IIPCLDVRDGQVVKGV--QFRNHEIIGDIVPLAKRYAEE--GADELVFYDITASSDGRVV 61 + P +D+ V+ ++ + E + + Y + + + D+ + Sbjct: 4 LWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAR 63 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++ + + V GGI++ + G + + + + D + +A F Sbjct: 64 EFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFP 123 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + I DA VN + D T+ +V+++ G I+ + + Sbjct: 124 GR-----IYFSVDAYGEDIKVNGWEED------TELNLFSFVKQLSDIPLGGIIYTHIAK 172 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG +G + E ++ + +P+IASGG + + +V A+ H+ Sbjct: 173 DGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDI-QRLASLNVHAAIIGKAAHQASF 229 >UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZVN4_9SPHI Length = 246 Score = 164 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 40/248 (16%), Positives = 100/248 (40%), Gaps = 15/248 (6%) Query: 5 RIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +I+P + + G+VV+ ++ + + LA + G L D+ + ++V Sbjct: 3 KIVPSIAILGGKVVRTIKGDIDQVQVYDTNPLDLALEFENNGIKHLHLVDLDGAKARQIV 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + +A + GGI +D GA ++ + A+ + +G Sbjct: 63 NYNILEMLASYTQLEIDYTGGITRDDDIRTAFECGAKHVTAATVAVHEREKFLSWVITYG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 +++ D ++ + + T + ++ ++ +RG + + + Sbjct: 123 GNKVILAAD----------ALDGVVLTKGWRKNTGIDLVEHIKSYHERGVRFVKTTEIGR 172 Query: 182 DGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G G + + KK+R E + ++ASGG ++E E V G + ++ I Sbjct: 173 NGTLEGPNFDTYKKLRTEFPELQILASGGIRSIEDI-EQLDALGVAGVIIGKSYYDGQIK 231 Query: 241 IGELKAYL 248 + +L+ ++ Sbjct: 232 LKDLQKFI 239 >UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01ZU7_SOLUE Length = 227 Score = 161 bits (409), Expect = 2e-38, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 109/241 (45%), Gaps = 19/241 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 I+PC+D+ DG+VV+ +Q R + GD + +R+ G E+ D+ A+ G+ + + Sbjct: 2 IVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRF--AGFPEIQVIDLDAAL-GKGSNDT 58 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 V +A V GG+++L+ A +LS GA ++ + + A + + Sbjct: 59 LVKMLASKAVCR--VGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPAT 116 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 +V +D ++ G+ V + T++ + + ++ + ++++G+ Sbjct: 117 TIVALD----SKGGRIVVKGWQ------EATEFTAEEVLHSLEPY-CSGFLCTYVDKEGM 165 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 G DL+ ++R + A+GG T+E +A ++ A + +++ EL Sbjct: 166 MQGTDLDWFARLRAATAHEITAAGGITTLEDI-KALLAMNIHTA-VGMAIYTGRLDLEEL 223 Query: 245 K 245 + Sbjct: 224 R 224 >UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NHA2_KYTSD Length = 470 Score = 159 bits (403), Expect = 9e-38, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 94/254 (37%), Gaps = 21/254 (8%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + R+ P +DVR G + Q + D + +GA+ L D+ + G Sbjct: 1 MPLRLWPAVDVRGG---RTAQVDPDSPLSDPQAAVDHWVAQGAERLHLVDLDRA-TGAGE 56 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + R+ +P V+GGI S D + LS+GA ++ +S ADP G Sbjct: 57 NDALLERLVRRASVPVEVSGGILSPRDVERALSWGAVAVTTSSALWADPAAALEWLQGCG 116 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + + VGID D + T + D ++ G VL Sbjct: 117 AE-VQVGIDLVGDRVVAR-----------GTDLALGPVADLWPDLAGLGERRWVLASAAA 164 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDG-----ALAASVFHK 236 DG G DL L+ E LIASGG T + V G + + + Sbjct: 165 DGRMTGPDLAGLRAATEHLTGTLIASGGVSTTGDLVAVSSLRGVAGPAVGEVILGAALYA 224 Query: 237 QIINIGELKAYLAT 250 +++G + L Sbjct: 225 GAVDLGRAQRLLGE 238 >UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_MYXXD Length = 238 Score = 153 bits (387), Expect = 7e-36, Method: Composition-based stats. Identities = 42/238 (17%), Positives = 96/238 (40%), Gaps = 17/238 (7%) Query: 7 IPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IP +D+R+G V+ V + + + K++ G D+ A+ G+ + Sbjct: 4 IPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAAL-GKGSNA 62 Query: 64 SWVSRVAE-VIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + F V GG++ + +LS GA+ + + + A+ D + +A+RF Sbjct: 63 DAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +V D + + +T + + + + + G +++ ++++ Sbjct: 123 RVVVAA-----DVKGREVVTRGWTA------GSHRDIREVLAAFEPLPLGGLLVTAVHKE 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 G +G DL +++V L ASGG TME + + ++ Sbjct: 172 GQLSGVDLPLMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVI-GMALYTGRLD 228 >UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E352 Length = 229 Score = 150 bits (380), Expect = 4e-35, Method: Composition-based stats. Identities = 45/243 (18%), Positives = 95/243 (39%), Gaps = 25/243 (10%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI--IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 I P +D+ +G+ V + +I GD V A+ ++ L D+ + G + Sbjct: 4 IYPAIDIYNGEAVSLENGKIEKIESFGDPVKFAQEFSSISGK-LHIVDLNGAFTGNPANT 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + + + + GG +++E S G D I I + +L D ++ ++++ + Sbjct: 63 NLIKNIRKNVKSFMQAGGGYRTMESIEAGYSLGIDSIIIGTASL-DKKILEEVSEKH--K 119 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 I + ID + N Y T+ D+ V+ R A + +N DG Sbjct: 120 NITISIDAY----------NGYIKYNGWADGTEISYRDFYSMVKGR-ANRFIFTAINSDG 168 Query: 184 VRNGYDLEQLKKVREVCH-VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 + ++ + + +GG +++ + + +GA+ + I I Sbjct: 169 TG------HISRIEKFWDEGYFMYAGGVNSIDDLKK-LENMGFNGAIIGKALYNGNIKIE 221 Query: 243 ELK 245 ELK Sbjct: 222 ELK 224 >UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Picrophilus torridus RepID=Q6KZD4_PICTO Length = 222 Score = 145 bits (366), Expect = 1e-33, Method: Composition-based stats. Identities = 41/250 (16%), Positives = 88/250 (35%), Gaps = 47/250 (18%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 + P +D+ +G+ V R + GD V A R+ E D L D+ + + + ++ Sbjct: 4 VYPAIDIYNGRAVFLENGRLERIKVYGDPVYYALRFQEY-FDFLHVIDLNGAIENKRKNR 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + + + V GG+++L D + FGA I + + + Sbjct: 63 DVIKNIIKEVKAKVQVGGGLRTLNDVIDVYDFGAYSAIIGTNIDIEVD-----------K 111 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + + ID + D + +T + + + + ++ R + + DG Sbjct: 112 NVTLSIDVYKDR----------VANRGWLNITDNDPVSFYKMLKNR-FSRFIYTNIGSDG 160 Query: 184 VRNGYDLEQLKKVREVCHVP--------LIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 +P I +GG + +A ++ G + + Sbjct: 161 T-------------NNSGIPEKFWDNEYFIYAGGVSGINDVKKALKN-GFSGIIIGRALY 206 Query: 236 KQIINIGELK 245 + I+ GELK Sbjct: 207 ENRIDPGELK 216 >UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC778 Length = 164 Score = 141 bits (356), Expect = 2e-32, Method: Composition-based stats. Identities = 65/158 (41%), Positives = 92/158 (58%), Gaps = 5/158 (3%) Query: 16 QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDI 75 + KG +F++ + L K Y++ GADELVFYDITAS++ R +V++VAE I+I Sbjct: 8 KSCKGKKFKDIVDVDSPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENINI 67 Query: 76 PFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDA 135 PFCV GG+ LED IL GADK+SINS A+ +P LI + +FG QC+V+ ID + Sbjct: 68 PFCVGGGVNKLEDFTDILRKGADKVSINSSAVKNPELIREASLKFGAQCVVLSIDAKKN- 126 Query: 136 ETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 E G + V G E W L+ + +V + G Sbjct: 127 EEGSWSVYVKGGREKLI----WMQLNGLLKVVELGVRR 160 >UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M908_CALMQ Length = 228 Score = 140 bits (355), Expect = 3e-32, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 102/241 (42%), Gaps = 28/241 (11%) Query: 2 LAKRIIPCLDVRDGQVV---KGVQFRNHEIIG--DIVPLAKRYAEEGADELVFYDITASS 56 +++ +IP +D+ +G VV +GV+ + + + L K Y + D+ + Sbjct: 1 MSRLVIPSIDLSNGLVVKRVRGVKGSELVKLNLNEALSLVKDY-----PFIHVVDLNGAE 55 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 G+ ++ ++++ ++ V GG++ +EDA +L + ++ + + A+ +P L+ + Sbjct: 56 LGKPINVDSIAKIGATVNGRCEVGGGVRVIEDAELLLKY-CSRVVLGTVAVENPALLLNM 114 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 +R GV + V +DT + + R + L + ++ Sbjct: 115 INRLGVDKVAVSLDT----DGEWLMTRGWGVRARRI----MDALSNLPR-----VSAVIY 161 Query: 177 NMMNQDGVRNGY--DLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 ++ +G G + E +K++R++ + +GG + +E DG + Sbjct: 162 TNVSVEGTGMGPRVNGELVKRLRDI-GKEVYYAGGVSSCSD-VEYLWGLGFDGVIIGYAL 219 Query: 235 H 235 + Sbjct: 220 Y 220 >UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TG14_METVO Length = 148 Score = 140 bits (353), Expect = 6e-32, Method: Composition-based stats. Identities = 32/126 (25%), Positives = 66/126 (52%), Gaps = 4/126 (3%) Query: 29 IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED 88 + +AK + E GA+ L D+ + DG V+ V ++ + +P + GGI+++ED Sbjct: 3 YDNPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIED 62 Query: 89 AAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGD 148 ++++ G +++ I + A+ +P + +LA + G + I+V +D A+ GK + + Sbjct: 63 VEELVNLGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVALD----AKDGKVVIKGWKEK 118 Query: 149 ESRTRV 154 T V Sbjct: 119 TEYTPV 124 Score = 40.5 bits (94), Expect = 0.059, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 46/102 (45%), Gaps = 5/102 (4%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNG--YDLEQLKKVREVCHVPLIASGGAGTMEH 215 + + + GA + L ++ DG +G +L +KK+ + VP+ GG T+E Sbjct: 5 NPDEIAKMWVENGAEMLHL--VDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIED 62 Query: 216 FLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 +E + ++ + +V + + +L + ++ + + + Sbjct: 63 -VEELVNLGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVAL 103 >UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZ82_ACIFD Length = 246 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 49/257 (19%), Positives = 92/257 (35%), Gaps = 21/257 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQ--FRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD-GRV 60 ++ +D+ DG+ V+ Q F GD + + GA D+ + G Sbjct: 1 MELVVAVDLLDGEAVRLRQGRFDAPRRFGDPRRYVEGALDAGARWFHVVDLDRARTPGDR 60 Query: 61 VDKSWVS---RVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + V + V GG+++ D A++L GA ++ + + L+ Sbjct: 61 RNADMVGDLIALVREAGGSVEVGGGVRTARDIAELLETGASRVVLGTA------LVEETL 114 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 D + +V +D E V + R L+ + RG +L Sbjct: 115 DELDPEHLVAALDYRRGDEGALEVV-----VSAWERSGGRRLLEASARLFARGVRTQLLT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD----VDGALAASV 233 + +DG+ +G DL + + EV V +IASGG + + + V GA+ + Sbjct: 170 DVGRDGMASGPDLGTYQGLCEVVPVEVIASGGVASADDLAKLAAIRGARGAVWGAVVGTA 229 Query: 234 FHKQIINIGELKAYLAT 250 + E + Sbjct: 230 LLDGSLGFDEALSACRA 246 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 137 bits (345), Expect = 5e-31, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 97/242 (40%), Gaps = 27/242 (11%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q I ++ L + ++ G E+ D+ A+ G+ + Sbjct: 2 LIPSIDLLDGKAVQLQQGDASRKIVEKDNLFELLEEFSLFG--EVAIIDLNAAL-GKGDN 58 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 K+ + ++ + V GGI++ E A + LS GA KI + + D + Sbjct: 59 KALIKQLIKKFSCR--VGGGIRNYETAREYLSSGAKKIILGTSCRED------FVKKLPR 110 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 ++ ID D + + + E+Q E + + ++ Sbjct: 111 SQLIFAIDAKGDDWV----------THGWQSSSDNKVAAMIDELQDN-CSEFLYTQVEKE 159 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G D E++++V + + + +GG ++ + + L S+ + + + Sbjct: 160 GMMQGIDRERIEQVIKQSKIQVTVAGGITDLDDI-KFINKLGANSQLGMSI-YTGKLKLD 217 Query: 243 EL 244 E Sbjct: 218 EA 219 >UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V5Z6_9AQUI Length = 119 Score = 136 bits (344), Expect = 6e-31, Method: Composition-based stats. Identities = 31/117 (26%), Positives = 64/117 (54%), Gaps = 3/117 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNH--EIIGD-IVPLAKRYAEEGADELVFYDITASSDG 58 L + IIP +D+++G+ V+ + + ++ GD V +AKR+ E+GA L D+ + +G Sbjct: 3 LKEFIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHIVDLDGAFEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + V ++ + +++P GG+++ E K++ G +++ I S A D L + Sbjct: 63 IPKNYKIVEQIVKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDKELFEK 119 Score = 48.5 bits (115), Expect = 2e-04, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 52/112 (46%), Gaps = 6/112 (5%) Query: 129 IDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGY 188 I D + G+ V Y GD + +V ++ + +++GA + + ++ DG G Sbjct: 7 IIPAVDIKEGR-AVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHI--VDLDGAFEGI 63 Query: 189 --DLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 + + ++++ + +VP+ GG T E ++ + V+ + S+ ++ Sbjct: 64 PKNYKIVEQIVKSVNVPIEFGGGLRTYE-AVKKMIEIGVERVVIGSLAYQDK 114 >UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TGW8_METVO Length = 181 Score = 136 bits (344), Expect = 7e-31, Method: Composition-based stats. Identities = 48/142 (33%), Positives = 81/142 (57%), Gaps = 5/142 (3%) Query: 80 AGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGK 139 GGIK+ E+A+KI G +KIS+NS P+L+T L+ +G Q IV +D + GK Sbjct: 12 GGGIKTFEEASKIFELGFEKISLNSVLFEKPSLLTELSQSYGSQSIVASVDVKKNL-FGK 70 Query: 140 YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREV 199 V + S+ + LD+V+ ++ GAGE+++N ++ +G GY+L + ++ Sbjct: 71 LKVY----NGSKNNSINDKILDYVKNLENLGAGELLINSVDLEGTYKGYNLSLINELSNA 126 Query: 200 CHVPLIASGGAGTMEHFLEAFR 221 +PLIA GGA + + F +A + Sbjct: 127 LTIPLIALGGASSTKDFKDALQ 148 Score = 40.5 bits (94), Expect = 0.060, Method: Composition-based stats. Identities = 23/94 (24%), Positives = 40/94 (42%), Gaps = 9/94 (9%) Query: 6 IIPCLDVRD---GQVVKGVQFRNHEIIGD-IVPLAKRYAEEGADELVF--YDITASSDGR 59 I+ +DV+ G++ K + I D I+ K GA EL+ D+ + G Sbjct: 57 IVASVDVKKNLFGKL-KVYNGSKNNSINDKILDYVKNLENLGAGELLINSVDLEGTYKG- 114 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKIL 93 + S ++ ++ + IP GG S +D L Sbjct: 115 -YNLSLINELSNALTIPLIALGGASSTKDFKDAL 147 >UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermoproteaceae RepID=HIS4_PYRAE Length = 229 Score = 134 bits (337), Expect = 4e-30, Method: Composition-based stats. Identities = 49/241 (20%), Positives = 100/241 (41%), Gaps = 27/241 (11%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII--GDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP +D+ G+ VK ++ + I GD + LA R+ + A + D+ + G +V+ Sbjct: 2 IIPSIDIEGGRAVKRIRGQRGNYIFQGDPLELAARFRK--APLVHVVDLDGAEAGGLVNI 59 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 S +S++AE+++ + GG++SLE + LS + S + L R A+ + Sbjct: 60 SVISKIAEILEGRCELGGGLRSLEAVERALSL-CQYAVVGSLPFKNWPLFRRAAELY-RD 117 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG-AGEIVLNMMNQD 182 + V +D G+ V + R + V+ +++ G +++ + + Sbjct: 118 RLAVSLDY----RGGEVLVGGW-------REKAASIAEAVRRLEEAGPYAAVIVTSVEVE 166 Query: 183 GVRNGY----DLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 G G D++ LK++ + +GG A DG + + Sbjct: 167 GTGGGVKADIDVKSLKRIARR----VFYAGGVRDCNDVERA-YALGFDGVIVGYALYAGD 221 Query: 239 I 239 + Sbjct: 222 L 222 >UniRef50_Q1NTJ9 Histidine biosynthesis n=1 Tax=delta proteobacterium MLMS-1 RepID=Q1NTJ9_9DELT Length = 186 Score = 133 bits (336), Expect = 5e-30, Method: Composition-based stats. Identities = 45/129 (34%), Positives = 71/129 (55%) Query: 129 IDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGY 188 I T + G+ + + + ++ GAGEI+LN +++DG +G+ Sbjct: 56 IPTAFHGPNGEKYCWYQCTVKGGREGRDLDAATLAVACEELGAGEILLNCIDKDGTNSGF 115 Query: 189 DLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYL 248 DLE +K V+E +P+IAS GAG EHF E F D ALAA +FH++ + I E+K +L Sbjct: 116 DLELVKMVKEAVTIPVIASSGAGKPEHFSEVFTVTGADAALAAGIFHRREVAISEVKEHL 175 Query: 249 ATQGVEIRI 257 G+E+R+ Sbjct: 176 QRHGIEVRL 184 >UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Sulfolobus RepID=HIS4_SULSO Length = 232 Score = 132 bits (334), Expect = 8e-30, Method: Composition-based stats. Identities = 42/238 (17%), Positives = 96/238 (40%), Gaps = 19/238 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP +D+ G+ VK ++ ++G+ + LA + EG + D+ A+ +G ++ Sbjct: 4 IIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAA-EGVGNNE 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ + ++ V GGI+ +E A +++S + + ++ + L + G Sbjct: 63 MYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGNN 122 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 ++V ID +T + ++ + E +D +++V + I+L + +G Sbjct: 123 RVIVSIDY---DDTKRVLISGWKERS-------MEIIDGIKKVNELELLGIILTYVTNEG 172 Query: 184 VRNGYDLEQ--LKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 G D K+ +GG + ++ D + F+ I Sbjct: 173 TVKGIDYSVKDYAKLIRGVKE---YAGGVSSDSDI-TFLKNVGFDYIIVGMAFYLNKI 226 >UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Acidobacteria RepID=Q1IKB1_ACIBL Length = 228 Score = 132 bits (333), Expect = 1e-29, Method: Composition-based stats. Identities = 40/242 (16%), Positives = 94/242 (38%), Gaps = 23/242 (9%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 +IP +D+ G++V+ VQ D +R+ G + D+ A+ + ++ Sbjct: 2 LIPSIDLMGGKIVQLVQGEKKAFETTDFDAWCERF--AGFPMVQLIDLDAAKR-QGDNRE 58 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP----TLITRLADRF 120 ++ + + +P V GG++ + A ++L+ GA ++ + S + D LA+R Sbjct: 59 LIANIV--LRLPCQVGGGVRDADVAERLLAIGAKRVIVGSSYIRDGRVDVDFARGLAERC 116 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G ++ ID+ + + + + G + ++ Sbjct: 117 GTDRVIAAIDSR----------EGFVAVRGWQESVPITAGEMIAALTPY-VGGFLYTHVD 165 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G+ G+ + +++R + LIA+GG + E + VD + + Sbjct: 166 TEGLLVGFPTDIARRLRTLTEKQLIAAGGIRSQEEI-DELDGIGVDAV-VGMAIYTGKLV 223 Query: 241 IG 242 + Sbjct: 224 VK 225 Score = 40.5 bits (94), Expect = 0.054, Method: Composition-based stats. Identities = 24/98 (24%), Positives = 40/98 (40%), Gaps = 5/98 (5%) Query: 5 RIIPCLDVRDGQV-VKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 R+I +D R+G V V+G Q G+++ Y G D G D Sbjct: 120 RVIAAIDSREGFVAVRGWQESVPITAGEMIAALTPYV-GGFLYTH-VDTEGLLVGFPTDI 177 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKIS 101 + R+ + + AGGI+S E+ ++ G D + Sbjct: 178 A--RRLRTLTEKQLIAAGGIRSQEEIDELDGIGVDAVV 213 >UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9301 RepID=A3PE78_PROM0 Length = 222 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 48/213 (22%), Positives = 98/213 (46%), Gaps = 12/213 (5%) Query: 45 DELVFYDITASSDGRVVDKSWVSRVA---EVIDIPFCVAGGIKSLEDAAKILSFGADKIS 101 DE++ +++ + + + + ++ +P + G I+S+E+A ++ +FGADKI Sbjct: 15 DEILIINLSEKNWEEAYNNKFFNDISLLLSKTFLPITIGGKIRSIENAKELFNFGADKIL 74 Query: 102 INSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLD 161 I+ D L+ + D +GVQ IVV D + S +V+ + + Sbjct: 75 ISRAFFQDQNLLKEIRDLYGVQSIVVQFDINSQNYD-------IFINSSLEKVSNLKKIV 127 Query: 162 WVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR 221 + + GE+++N +++DG G++ E L + + ++PLIASGG G+ H E + Sbjct: 128 YSLNEKNL-MGELIINQIDRDGTGFGHNTEYLNAIPK-LNMPLIASGGFGSSIHMAECLK 185 Query: 222 DADVDGALAASVFHKQIINIGELKAYLATQGVE 254 + +++ + E + L E Sbjct: 186 FDSISAVATSNLLNFIGDAFSEARQELRKMNFE 218 >UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=1 Tax=Cyanothece sp. PCC 7425 RepID=B8HVG9_CYAP4 Length = 226 Score = 130 bits (328), Expect = 5e-29, Method: Composition-based stats. Identities = 45/218 (20%), Positives = 91/218 (41%), Gaps = 19/218 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP L + +G Q + D V +A+++A +GA L D + G +++ Sbjct: 1 MEIIPALKIMEGFCCHHRQ--PYRFNCDPVAMAEQWANQGATRLHLIDCNGVTTGAMLNL 58 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISI-NSPALADPTLITRLADRFGV 122 ++ + + + +P V G I S + + G D++ + S + L+ L + F Sbjct: 59 PTIAAIVQQVKVPVQVEGTIYSRAQIETLFAIGVDRVVVDGSIGWS--ELVADLCEHFSG 116 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +V +A G+ + +T + + GA I+ + + Sbjct: 117 KIMV-----NLEAYDGRVACSG--------ELTGLLATTLAERAEAVGAAGIIYTDIARQ 163 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 G +L+ LK + + ++P+IA GGA ++ L F Sbjct: 164 GSGI-INLKALKHLADRVNLPIIAGGGASSIAELLRLF 200 >UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YI32_METS5 Length = 228 Score = 130 bits (327), Expect = 5e-29, Method: Composition-based stats. Identities = 44/238 (18%), Positives = 94/238 (39%), Gaps = 18/238 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +++P +D+ G VK V+ R ++GD + +A+ G + D+ A+ +G+ Sbjct: 1 MKVVPSIDISKGMAVKRVRGREGTGLVLGDPLKIAEELRNMGYTSVHLVDLDAA-EGKGD 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + RV + V GGI+ + LS GA K+ +++ A P R+ + Sbjct: 60 NVEVIERVMKDFS-EISVGGGIRDRSRLERFLSSGATKVVMSTLAFTKPDTFRRVVAGYE 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 ++V +D K + + + + + V G ++ + Sbjct: 119 N-RVLVSVDYC----ERKVLIKGWNE-------SAMSFEEAISHVNSLGVRGVIFTYVCN 166 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +G RNG D E + + + +GG G+++ E A+ + ++ Sbjct: 167 EGTRNGIDPE-IGRYVNLVQGEKGYAGGIGSIQDLQE-LDKMGFHFAIVGMSLYAGVL 222 >UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Sulfolobus acidocaldarius RepID=Q4J8J0_SULAC Length = 226 Score = 125 bits (314), Expect = 2e-27, Method: Composition-based stats. Identities = 45/238 (18%), Positives = 104/238 (43%), Gaps = 20/238 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +++P +D+ + VK ++ + I+GD + +AK EG D + D+ A+ +G Sbjct: 1 MKVMPSIDISNKVAVKRIRGKGGSGIILGDPLKIAKEIISEGYDAIHIVDLDAA-EGLGD 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +K + ++ + V GG++ LE A IL + I +++ + + ++ G Sbjct: 60 NKDIIKQICTLGFSWTQVGGGVRKLEIAKDILEY-CSSIVVSTLPITNRQEYDKIISGVG 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 V + + ID + G + + E +V+ L+ +G ++ + Sbjct: 119 VDKVFLSIDY---DDNGYVLIKGW--KEKSVKVSDLLDLE---------SGGVIFTYIPN 164 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +G + G D ++ V+ V + +GG G+++ L+ + D ++ F+ + Sbjct: 165 EGTKGGIDNNVVEYVKSVKKIK-EYAGGIGSLDDLLK-LKSFGFDYSIIGMSFYNGTL 220 >UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepID=Q4JIN2_9BACT Length = 248 Score = 105 bits (264), Expect = 1e-21, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 85/249 (34%), Gaps = 26/249 (10%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI------------IGDIVPLAKRYAE-EGADELVFY 50 R+I +D+ G+ V R + +GD LA+ Y E G EL Sbjct: 1 MRVIGVIDLAAGRAVHARGGRRTDYAPVRLSGAAAAHVGDPCALARTYLETRGLTELYVA 60 Query: 51 DITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP 110 D+ + G + + + + P + G+ S+ A L GA + + L Sbjct: 61 DLD-AIGGGPSQDAAIGALIR-LGAPLWLDSGVHSVPRARHALGLGASFVVVGLETLPSY 118 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 +++ + G + + +D + + G Sbjct: 119 DVLSEICADVGSERVAFSLDLR----------DGLPITAHADVAAGRSVEQIAARAVEAG 168 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALA 230 G I++ + + G+ G DL + +R V L+A GG E + A DG L Sbjct: 169 VGAIIVIDVARVGMGEGVDLALISSLRSVAPAVLLAGGGVRGSEDL-ASLAHAGCDGVLV 227 Query: 231 ASVFHKQII 239 A+ H I Sbjct: 228 ATALHDGRI 236 >UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3 Tax=Clostridiales RepID=C4Z9Z2_EUBR3 Length = 427 Score = 105 bits (264), Expect = 1e-21, Method: Composition-based stats. Identities = 32/126 (25%), Positives = 62/126 (49%), Gaps = 2/126 (1%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 K I+ L +++GQ VK + ++GD+ L + Y + G D+++ +D++ D + Sbjct: 5 KNIVATLYLKNGQAVKSA--SDMTVMGDVYNLCQLYNDSGIDKIIIFDLSTDDDEHEKNI 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + IDI C G I +ED K+L G ++ N+ + L +++FG Sbjct: 63 HTIENINRNIDIKVCAGGNINRIEDVKKLLYAGCLQVIFNATKDSSLELANVASEKFGKD 122 Query: 124 CIVVGI 129 I++ I Sbjct: 123 KILLSI 128 >UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanococcales RepID=Y703_METJA Length = 226 Score = 100 bits (251), Expect = 4e-20, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 98/253 (38%), Gaps = 45/253 (17%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYDITA 54 +IIP +D++D V G E + + +AK Y E GA + D+ Sbjct: 1 MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLN- 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED---AAKILSFGADKISINSPALADPT 111 G + + + I V G+KS ED K+L+ D+ + + L D Sbjct: 60 FIMGNGDNFDIIKEID---FINKIVDIGVKSREDLETIKKVLNKD-DRAIVATETLKDIE 115 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 L+ + IVV +D + + + E L V++ Sbjct: 116 LLKE-------KDIVVSLDFK---------------NGNLLNYSLDEILSCVRDDTPL-- 151 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 I+L ++ G + G + E +K V + + P+ GG ME E + VD L A Sbjct: 152 --IIL-DISSVGTQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDL-ELCYNLGVDAVLIA 207 Query: 232 SVFHKQIINIGEL 244 + HK ++++ E+ Sbjct: 208 TAIHKGVLDLEEI 220 Score = 59.7 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 34/76 (44%) Query: 47 LVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPA 106 L+ DI++ R V+ + V + + P V GGIK +ED + G D + I + Sbjct: 151 LIILDISSVGTQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAI 210 Query: 107 LADPTLITRLADRFGV 122 + + ++FG Sbjct: 211 HKGVLDLEEIINKFGD 226 >UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococcus sp. FS406-22 RepID=D1SND3_9EURY Length = 237 Score = 99.8 bits (248), Expect = 9e-20, Method: Composition-based stats. Identities = 54/258 (20%), Positives = 107/258 (41%), Gaps = 35/258 (13%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYDITA 54 +IIP +D+ + V G E + + +A Y E GA+ + D+ Sbjct: 1 MQIIPVIDLMNKIAVHGKSGNRDEYKPLKSVICNSPNPIDVAMAYKERGAETIYIADLN- 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIK-SLEDAAKILSFGADKISINSPALADPTLI 113 G + + + + ++ + + LE+ KIL+ DK + + L D L+ Sbjct: 60 FIMGNGDNFEVIKEI-DFVNKIVDIGVKRREDLENIKKILNKD-DKAIVATETLKDIELL 117 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 + IVV +D + G+ +++ D S + L +V+E Sbjct: 118 KE-------KDIVVSLDF----KNGELLLDKNFKDYSLDGI-----LSYVREDTPL---T 158 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 I+ ++ G + G ++E +K V + + P+ GG M+ E + VDG L A+ Sbjct: 159 IL--DISSVGTQRGINVELIKYVLDKTNNPVYVGGGIKGMDDL-ELCYNLGVDGVLIATA 215 Query: 234 FHKQIINIGELKAYLATQ 251 HK I+++ E+ + + + Sbjct: 216 IHKGILDLEEIISKFSDK 233 >UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41F9C Length = 231 Score = 99.4 bits (247), Expect = 1e-19, Method: Composition-based stats. Identities = 45/251 (17%), Positives = 88/251 (35%), Gaps = 31/251 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---------GDIVPLAKRYAEEGADELVFYD 51 ML IIP +D+ + V G D + +A GA E+ D Sbjct: 1 ML--EIIPVIDLMNSVAVSGKSGNRETYTPLQTIYASSSDPLEIALSLKSAGAKEMYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + + + V V+ + V G+ LE +L F A KI + + L Sbjct: 59 LDFIERNGNNNIFKIKEVNSVLPVILDV--GVDKLETFEFLLEF-AYKIIVATETLESIE 115 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + ++ +++ + I+V +D + E + + + + +++ Sbjct: 116 ELGKIFEKYPKERIIVSVDVKNN--------------ELYAKNMDLDLEGFKEVLRRIDP 161 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 EI+L ++ G G++ L+ E +I GG + + AL Sbjct: 162 NEIILLDISSVGTEGGFNKPLLESFEEFKDK-IILGGGIT--PDEISQLDALGIRKALVG 218 Query: 232 SVFHKQIINIG 242 + HK I + Sbjct: 219 TALHKGQIRLN 229 >UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methanobrevibacter smithii RepID=A5UNR3_METS3 Length = 229 Score = 98.6 bits (245), Expect = 2e-19, Method: Composition-based stats. Identities = 48/252 (19%), Positives = 95/252 (37%), Gaps = 32/252 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII---------GDIVPLAKRYAEEGADELVFYD 51 M+ K +P LD++D V G + V +A + GADEL D Sbjct: 1 MIKK--VPVLDLKDNIAVSGKSGLRDTYTPLQTVFAPSANPVDIANGLSINGADELYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + +G + V V +P + G+K E L + A KI + + + Sbjct: 59 LDL-IEGNGHNIHDVKMV--NSILPVMLDAGVKDFESFTFFLDY-AYKIIVPTETIKSIG 114 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 I ++ +++ + IVV +D + E ++ ++ + +++ Sbjct: 115 EIKKIFEKYPKERIVVSVDVKDN--------------ELYSKNLNISLAEFKEILEELDP 160 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 EI+L + G + GY+ E L +++ +IA GG + D + L Sbjct: 161 DEIILLDITGVGTQKGYNQELLDDFKDLKDKLIIA-GGLNNKS--VSELEDMGIKKVLVG 217 Query: 232 SVFHKQIINIGE 243 + H + + + Sbjct: 218 TALHSGEMKLLD 229 >UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales RepID=C9RDL3_METVM Length = 229 Score = 95.5 bits (237), Expect = 1e-18, Method: Composition-based stats. Identities = 52/255 (20%), Positives = 97/255 (38%), Gaps = 47/255 (18%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYDITASS 56 IIP +D++ V G + D + LAK Y E+G++ + D+ + Sbjct: 3 IIPVIDIKGNIAVHGKSGMRSKYQPLKSVICETSDPICLAKSYKEKGSEMVYIADLD-AI 61 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAK---ILSFGADKISINSPALADPTLI 113 G + + + + I V GIK+ ED + L+ DK I + L D LI Sbjct: 62 CGEGDNFNLIKNID---FINKIVDAGIKTREDLERVREYLNKN-DKAIIATETLIDKELI 117 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 + + I+V +D D T E L V++ Sbjct: 118 SE-------KNIIVSLDFK---------------DGKLLNYTVEEVLGLVRKDTPL---- 151 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCH--VPLIASGGAGTMEHFLEAFRDADVDGALAA 231 I+L ++ G G +++ + + ++ P+ GG + E + +DG L Sbjct: 152 IIL-DISSVGTGRGINMKLINMILKLNKGKNPIYVGGGIRDITDI-EKCYNLGIDGVLVG 209 Query: 232 SVFHKQIINIGELKA 246 + H+ +I++ E+ Sbjct: 210 TAIHRGVIDLEEVIK 224 Score = 62.4 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 51/119 (42%), Gaps = 14/119 (11%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 K II LD +DG K + + E++G L ++ L+ DI++ GR ++ Sbjct: 120 KNIIVSLDFKDG---KLLNYTVEEVLG----LVRK-----DTPLIILDISSVGTGRGINM 167 Query: 64 SWVSRVAE--VIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + + P V GGI+ + D K + G D + + + + + +F Sbjct: 168 KLINMILKLNKGKNPIYVGGGIRDITDIEKCYNLGIDGVLVGTAIHRGVIDLEEVIKKF 226 >UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=O26765_METTH Length = 227 Score = 95.2 bits (236), Expect = 2e-18, Method: Composition-based stats. Identities = 49/246 (19%), Positives = 89/246 (36%), Gaps = 33/246 (13%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYD 51 ML IIP +D+ DG V G + D V +A GA + D Sbjct: 1 ML--EIIPVIDLMDGIAVSGKSGEREKYRPLESVYSPSPDPVNIALSLRAAGARSIYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + + +G + V RV V +P + G++ LE +L F A ++ + + L Sbjct: 59 LD-AIEGTGSNLEAVRRVNHV--LPVILDAGVRDLETFHFMLEF-ASRVVVATETLESTE 114 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + + + + VV +D + + H + E D + + Sbjct: 115 ELEEILRNYPPERTVVSVDV----KDMRLHSR-------NLEIGLEELRDLLMGYEV--- 160 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 +I+L + G +G++ E L+ R + +I GG + + V AL Sbjct: 161 -DIILLDIGSVGTSSGFNRELLELFRPLIE-RVIPGGGV--LPEEIPELEAMGVRAALVG 216 Query: 232 SVFHKQ 237 H+ Sbjct: 217 RALHEG 222 >UniRef50_D2MIW0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIW0_9BACT Length = 104 Score = 86.3 bits (213), Expect = 9e-16, Method: Composition-based stats. Identities = 18/103 (17%), Positives = 41/103 (39%), Gaps = 1/103 (0%) Query: 149 ESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASG 208 T V++ + +++ ++ +++DG+ G ++ L+ VPLIASG Sbjct: 2 HGWTNVSESTAEPVLASLKEYPLAGVIFTEISRDGMLEGPNVAALRDAVRASPVPLIASG 61 Query: 209 GAGTMEHFLEAFRDA-DVDGALAASVFHKQIINIGELKAYLAT 250 G +E R + G + ++ +++ A Sbjct: 62 GVTRVEDIRAIKRLGQKIIGVIVGKALYEGTLDLPAALAEARA 104 >UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oceani RepID=Q3JEF8_NITOC Length = 235 Score = 84.7 bits (209), Expect = 3e-15, Method: Composition-based stats. Identities = 47/259 (18%), Positives = 94/259 (36%), Gaps = 38/259 (14%) Query: 4 KRIIPCLDVRDGQVV--KGVQFRNHEIIGDIVP--------LAKRYAEEGADELVFYDIT 53 +++P LD+ G VV +G Q ++ + +A +L D+ Sbjct: 1 MQLLPVLDLWGGVVVHARGGQRDSYLPLNSPFAPNSSPLQVVAGLLQWCRFQQLYIADLN 60 Query: 54 ASSDGRVVDKSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 + G + ++ +A D+ V GG E A++ + G + + + L D Sbjct: 61 -AIMGDGNNHFMIAAIARSYPDLELWVDGGTARHEAVAQLFALGVARPVVGTETLPDLES 119 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 + + + + +D A + G R + G Sbjct: 120 W-QALQSSWPEQLALSMDHRRGA---------FLGPAGLDRQPELWP------------G 157 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVC---HVPLIASGGAGTMEHFLEAFRDADVDGAL 229 ++ ++Q G + G D L+++ + + L+A+GG +E + V+G L Sbjct: 158 TVIAMSLDQIGSQQGPDWSLLERLGQRSLRKRISLLAAGGVRCLEDLKQ-LAAWGVEGVL 216 Query: 230 AASVFHKQIINIGELKAYL 248 AS H +N EL+ L Sbjct: 217 LASALHDGSLNPAELQQML 235 >UniRef50_Q10184 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=71 Tax=cellular organisms RepID=HIS4_SCHPO Length = 264 Score = 84.0 bits (207), Expect = 5e-15, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 86/243 (35%), Gaps = 31/243 (12%) Query: 8 PCLDVRDGQV---VKGVQFRNHEIIGDIVPL------AKRYAEEGADELVFYDITASSDG 58 PC+D+ GQV V G + ++ + V L A+ Y + + Sbjct: 11 PCIDIHQGQVKQIVGGTLGNDADVKTNYVSLKPSSYYAELYKLNHLEGAHVIML------ 64 Query: 59 RVVDKSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL----I 113 + ++ A + GGI ++ +A L GA K+ + S D + Sbjct: 65 -GPNCEEAAKTALHTWPGALQIGGGI-NISNAQNWLQEGASKVIVTSWLFPDAQFDLDRL 122 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 ++ + G +VV D + ++ E LD + + E Sbjct: 123 KAISSKIGKDRLVV--DVSCRRKDNRWFAAINKWQVMTAFELNEENLDLLSQY----CSE 176 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME--HFLEAFRDADVDGALAA 231 +++ + +G+ G D + + K+ E +P +GG ++E ++ VD Sbjct: 177 FLIHAADVEGLCKGIDEDLVIKLGEWVKIPTTYAGGGRSIEDLDLVDKLSKGKVD-LTIG 235 Query: 232 SVF 234 S Sbjct: 236 SAL 238 >UniRef50_Q9F8I8 Cyclase (Fragment) n=1 Tax=Carboxydothermus hydrogenoformans RepID=Q9F8I8_CARHY Length = 114 Score = 83.6 bits (206), Expect = 5e-15, Method: Composition-based stats. Identities = 26/84 (30%), Positives = 48/84 (57%), Gaps = 5/84 (5%) Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 ++ GID + G + V + G T + ++W +EV++ GAGEI+L M++ Sbjct: 36 GSHVLCGIDAKRK-KDGGFEVYIHGGR----TPTGIDAVEWAKEVERLGAGEILLTSMDR 90 Query: 182 DGVRNGYDLEQLKKVREVCHVPLI 205 DG ++GYDLE +++ + +P+I Sbjct: 91 DGTKDGYDLELTREIADAVKIPVI 114 >UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole carboxamide isomerase family protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C36C9 Length = 235 Score = 82.4 bits (203), Expect = 1e-14, Method: Composition-based stats. Identities = 43/244 (17%), Positives = 79/244 (32%), Gaps = 27/244 (11%) Query: 13 RDGQVVKGVQF--RNHEIIGDIV-------PLAKRYAEE-GADELVFYDITASSDGRVVD 62 +G VV+ V +N+ + + +A+ GA EL D+ + G Sbjct: 1 MNGVVVRAVGGDRKNYRPVRSPLTPSTVPTDIAQALLRSVGAGELYVADLD-AITGSARV 59 Query: 63 KSWVSRVAEVIDIPF--CVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V + E +P G + D + + P ++ Sbjct: 60 TPSVEALMEACAVPVWLDAGTGRR---DVLDWPPHQNLRPVVGFETCRVPEVLAEALLEP 116 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + + +D G + GD + L + V G +++ + Sbjct: 117 RQRPVAFSLDLRNGQLLGNWRAWGLAGDR--------DALALTRRVVDMGVRTLIVLDLA 168 Query: 181 QDGVRNGYDLEQLKKV--REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 + G G ++L +V E + LIA GG T +E A G L AS H+ Sbjct: 169 RVGTGTGAGTDELVRVIRAEFPDLDLIAGGGVRTWSD-VERLGKAGATGVLVASALHEGT 227 Query: 239 INIG 242 + + Sbjct: 228 LVLP 231 >UniRef50_O82782 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic n=33 Tax=cellular organisms RepID=HIS4_ARATH Length = 304 Score = 81.3 bits (200), Expect = 3e-14, Method: Composition-based stats. Identities = 41/246 (16%), Positives = 90/246 (36%), Gaps = 31/246 (12%) Query: 8 PCLDVRDGQVVK--GVQFRNHEIIGDIV-----------PLAKRYAEEGADELVFYDITA 54 PC+D+ G+V + G R+ + G ++ AK Y E+G + A Sbjct: 48 PCIDIHKGKVKQIVGSTLRDLKEDGSVLVTNFESDKSAEEYAKMYKEDGLTGGHVIMLGA 107 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALAD----P 110 + + + + V GGI S E+ + GA + + S + Sbjct: 108 ---DPLSQAAAIGALHAYPGG-LQVGGGINS-ENCMSYIEEGASHVIVTSYVFNNGKIDL 162 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 + + G Q ++ +D + G+Y + + + ++L+++ Sbjct: 163 ERLKDIVSIVGKQRLI--LDLSCRKKDGRYAIVTDRWQKFSDVILDEKSLEFLGGFSD-- 218 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDADVDGA 228 E +++ ++ +G + G D E + + +P+ +GG M+ ++ VD Sbjct: 219 --EFLVHGVDVEGKKLGIDEELVALLGNYSPIPVTYAGGVTVMDDVERIKDAGKGRVD-V 275 Query: 229 LAASVF 234 S Sbjct: 276 TVGSAL 281 >UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEW9_METST Length = 239 Score = 79.4 bits (195), Expect = 1e-13, Method: Composition-based stats. Identities = 37/243 (15%), Positives = 86/243 (35%), Gaps = 28/243 (11%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI------IGD-IVPLAKRYAEEGADELVFYDITASSDG 58 IIP +D+ + V G R GD + +A E+GA + D+ Sbjct: 5 IIPVIDIMHNECVSGKSGRRSTYKKLRSIYGDNPLDIATALKEDGAQLIYIADLDKIERI 64 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + IP + GI S+ED + + + + I + Sbjct: 65 DDNNN---IISSINNIIPVMLDNGISSIEDIENNKNI-CSYNILATETMTSLDNIEEIFK 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 ++ +VV ID + E + D + + K ++ Sbjct: 121 KYDSNKLVVSIDIKNN--------------ELLVNNKDIDLEDVIYLINKYKPKYTIILN 166 Query: 179 MNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 ++ G + G + ++++ +++ H +GG + +E + +++ L ++ H+ Sbjct: 167 ISYVGTKKGVNTNIIEEITKKIPHTKCCIAGGIRNSD--IETYTKKNINNFLIGTLLHEG 224 Query: 238 IIN 240 ++ Sbjct: 225 NLS 227 >UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobiales RepID=C6QGP7_9RHIZ Length = 235 Score = 79.0 bits (194), Expect = 2e-13, Method: Composition-based stats. Identities = 45/258 (17%), Positives = 89/258 (34%), Gaps = 44/258 (17%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---------GDIVPLAKRYAE-EGADELVFYDITAS 55 IIP +DV G+VV+ +Q + + + +A+ D+ Sbjct: 3 IIPVIDVSRGKVVRAIQGKRAAYLPIETPLAATSEPGDVARGLRSLYPFRRAYVADLDG- 61 Query: 56 SDGRVVDKSWVSRVAEV---IDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 +GR + V +++ ++ G +S A +L+ + + S +L Sbjct: 62 IEGRGRNTHLVPELSQALPNTELWIDAGTGSRS--AARAVLAAPVATLVVGSESLESVRA 119 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 ++ + V+ +D D G + + Sbjct: 120 WHEISAEAPGRT-VLSLDFRGDEFMG--------------------PEALLADAALWPTR 158 Query: 173 EIVLN--MMNQDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGAL 229 IV+ + +G G ++ L+ + + A+GG ++E A GAL Sbjct: 159 VIVMTLDRIASEG---GPNIALLETIAARAGGRRVYAAGGIRSLEDLAR-IGKAGAAGAL 214 Query: 230 AASVFHKQIINIGELKAY 247 AS+ H Q I+ G+LK Sbjct: 215 VASILHAQKISAGDLKEI 232 >UniRef50_C4ZG69 APG10 (Albino and pale green 10); 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase n=3 Tax=cellular organisms RepID=C4ZG69_EUBR3 Length = 261 Score = 78.6 bits (193), Expect = 2e-13, Method: Composition-based stats. Identities = 44/266 (16%), Positives = 94/266 (35%), Gaps = 29/266 (10%) Query: 8 PCLDVRDGQVVKGVQFRNHEIIGDIVP-----------LAKRYAEEGADELVFYDITASS 56 PC+D+ +G+ VK + + + GD A Y + G + + Sbjct: 5 PCIDIHNGK-VKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLNSVD 63 Query: 57 DGRVVDKSWVSRVAEVIDIP-FCVAGGIKSLEDAAKILSFGADKISINSPALADPTL--- 112 D + +A V GGI + ++A + + GA + + S D + Sbjct: 64 SEYYEDTKEQAVMALEAYPQGLQVGGGI-TADNAMEFIDAGAAAVIVTSYVFKDGRINYA 122 Query: 113 -ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + RL D G +V +D + G+Y++ E LD + Sbjct: 123 NLNRLKDTVGSDRLV--LDLSCRKKDGQYYIVTDRWQNFTDEAVTTELLDKLSSY----C 176 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD--GAL 229 E +++ ++ +G NG + E + + +P+ +GG + + + R + Sbjct: 177 CEFLVHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDL-KCIRQLGQNHLNVT 235 Query: 230 AASV--FHKQIINIGELKAYLATQGV 253 S + ++ A+ + + Sbjct: 236 IGSALDLFGGEMEYDKVIAFCNNKEI 261 >UniRef50_B2UL06 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=4 Tax=cellular organisms RepID=B2UL06_AKKM8 Length = 261 Score = 77.4 bits (190), Expect = 5e-13, Method: Composition-based stats. Identities = 43/250 (17%), Positives = 88/250 (35%), Gaps = 31/250 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYA-EEGADELVFYDI---TASS 56 M R PC+D+ G+V Q + D V L + + GA + D+ S Sbjct: 1 MTRFR--PCIDLHGGRV---KQIVGGTLTQDGVSLRTNFVSDRGAAW--YADLYRRDGLS 53 Query: 57 DGR-----VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALA--- 108 G + V GG+ + E+A + +S GA + + S Sbjct: 54 GGHVIKLGPGNDHAAREALAAWPGGLQVGGGM-TPENAEEWISAGASHVIVTSCLFDAEG 112 Query: 109 --DPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEV 166 + L G + +V+ + +N++ +T+ +V Sbjct: 113 TLRMDRLKDLVSAVGAERLVLDLSCRRVQGGWAVAMNRWQ------TLTELRVTAETLDV 166 Query: 167 QKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF--LEAFRDAD 224 E +++ + +G+ +G D E ++ + +P+ +GG ++ ++A Sbjct: 167 LAEHCAEFLIHAADVEGLCSGIDRELVEMLGNWRRLPMTYAGGISRIQDIDEIDALSGGT 226 Query: 225 VDGALAASVF 234 +D A S Sbjct: 227 MD-ATVGSAL 235 >UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C0W3_9PLAN Length = 247 Score = 74.7 bits (183), Expect = 3e-12, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 80/248 (32%), Gaps = 22/248 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEE-GADELVFYDIT 53 +IIP LD+ + +V+G+ + + +A+ +E G E D+ Sbjct: 1 MKIIPVLDILNQTIVRGIAGQRETYQPIQSGLTHSSQPLDIAQALQDEFGFSEFYVADLD 60 Query: 54 ASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 A R+ + + + + G+ D+ + I L P + Sbjct: 61 AILQQRL-NLQMYQCLLDAGFTFL-LDCGLHFAGDSQPLSKMKGITIVAGLETLESPQEL 118 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 +L +G V +D + L+ + ++G + Sbjct: 119 KQLVQNWGAASTVFSLDLKQGKP-------VRNSSSDNPYAAIDDPLEIAELSLQQGVNQ 171 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREV--CHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 ++L + G G E L + + LI GG +++ + + D L A Sbjct: 172 MILLDLANVGTGQGTGTEALCRTLRSHHPDLRLITGGGIHSIDDL-QTQAEQGADAVLVA 230 Query: 232 SVFHKQII 239 S H + Sbjct: 231 SALHDGRL 238 >UniRef50_D1JF95 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=uncultured archaeon RepID=D1JF95_9ARCH Length = 238 Score = 74.0 bits (181), Expect = 5e-12, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 88/251 (35%), Gaps = 31/251 (12%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEII-----------GDIVPLAKRYAEEGADELVFY 50 + R+I +D+ DG VV + + + D A+ E+ Sbjct: 1 MDFRLIFVMDLLDGVVVHAKRGEREKYVPIHRFSSIVTSSDP---ARVIETIKPKEVYIA 57 Query: 51 DITASSDGRVVDKSWVSRV-AEVIDIPFCVAGGIKSLEDAAKILSFG-ADKISINSPALA 108 D+ ++ + + D+ + G+K +ED + + ADK + + ++ Sbjct: 58 DLNR-LLSTGNNRPILKDLRTRNRDLRIMLDYGVKGMEDLKEAVDAEMADKFVLGTETIS 116 Query: 109 DPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQK 168 L+ + + + + + L ++E+ K Sbjct: 117 -IELLEEASKS------------DIITDISISIDLFNNEVLTSDTRMKIDPLRLIKELNK 163 Query: 169 RGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGA 228 ++++ +N+ G ++G D E L + E+ ++ GG E + + V GA Sbjct: 164 FPVRDVIVLELNRVGTKSGIDFEFLARAVELSEHDILCGGGVRNCEDVHK-MAEIGVKGA 222 Query: 229 LAASVFHKQII 239 L A+ H I Sbjct: 223 LVATAIHDGGI 233 >UniRef50_Q2FS89 Histidine biosynthesis n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FS89_METHJ Length = 226 Score = 72.4 bits (177), Expect = 1e-11, Method: Composition-based stats. Identities = 41/247 (16%), Positives = 72/247 (29%), Gaps = 36/247 (14%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII------GDIVPLAKRYAEEGADELVFYDITASSDGR 59 + D++ G++V G + D + + L D+ G Sbjct: 3 LYLATDLKSGKIVHGKSGMRDRYVPVTSLHADTAEPIRFIEQMKPRFLYIADLDR-ICGT 61 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + +AE + +L G P + D Sbjct: 62 GDHDPLIPELAERTE---------------RILLDRGC----------KGP---YDMLDI 93 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FGV IV V + + ++ + ++L + Sbjct: 94 FGVSMIVGTETAADTLAQFTKGVLSVDIKNDLVIPWNIDPVTFLSTCNRYRFEMVILLDI 153 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 + G G D E L + REV PL+ GG + E A DGA+ A+ H I Sbjct: 154 GRVGTGRGLDKEMLSQFREVYTGPLLWGGGVSSEEDL-ALLEKAGFDGAIIATAVHSGKI 212 Query: 240 NIGELKA 246 + ++ Sbjct: 213 PVEYIRR 219 >UniRef50_B7GE60 Predicted protein n=11 Tax=cellular organisms RepID=B7GE60_PHATR Length = 279 Score = 72.0 bits (176), Expect = 2e-11, Method: Composition-based stats. Identities = 40/265 (15%), Positives = 80/265 (30%), Gaps = 45/265 (16%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIG-------------------------DIV-PL 35 + R PC+D+ GQ VK + Sbjct: 1 MKFR--PCIDLHHGQ-VKQIVGSTLRFTSPTTDHDDDTVTASSVPELATNFATERPAREF 57 Query: 36 AKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSF 95 A+RYA +G + + V GG+ +A + L Sbjct: 58 AERYARDGLTGGHVILL------GPGNADAARAALRAAPGTLQVGGGVHD-ANAREWLDA 110 Query: 96 GADKISINSPALADPTL----ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESR 151 GA + + S ++ + + RL G + +V+ + + Y Sbjct: 111 GASHVIVTSHVFSNGQIAMDRLERLVQLIGKERLVLDLSCRKRPDDHNNGPY-YVVTNQW 169 Query: 152 TRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAG 211 T++ E +++ ++ +G++ G L+ L + VP+ +GG Sbjct: 170 QVFTEYAVTTESLRTLAAYCDEFLVHGVDVEGLQCGI-LDDLVTLLATSPVPVTYAGGVR 228 Query: 212 TMEHF--LEAFRDADVDGALAASVF 234 +++ +E VD S Sbjct: 229 SIDDLNRVEQLGQGKVD-CTVGSAL 252 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hi... 269 6e-71 UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hi... 266 5e-70 UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hi... 262 8e-69 UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hi... 261 2e-68 UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hi... 260 5e-68 UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hi... 259 9e-68 UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hi... 258 2e-67 UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hi... 252 6e-66 UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hi... 249 5e-65 UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hi... 246 5e-64 UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hi... 243 4e-63 UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hi... 241 2e-62 UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hi... 241 2e-62 UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillon... 240 3e-62 UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococ... 238 9e-62 UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 237 2e-61 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 237 4e-61 UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hi... 237 4e-61 UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 6e-61 UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hi... 235 9e-61 UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hi... 235 1e-60 UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hi... 235 1e-60 UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hi... 235 1e-60 UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hah... 234 2e-60 UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hi... 232 7e-60 UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 232 9e-60 UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 232 1e-59 UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hi... 232 1e-59 UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hi... 231 2e-59 UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 231 2e-59 UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 3e-59 UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 3e-59 UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 4e-59 UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 5e-59 UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 228 1e-58 UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 227 3e-58 UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 225 1e-57 UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxa... 225 1e-57 UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hi... 225 1e-57 UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hi... 224 2e-57 UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 3e-57 UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxa... 223 3e-57 UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 3e-57 UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 3e-57 UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase s... 223 3e-57 UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 4e-57 UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, c... 223 5e-57 UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hi... 223 6e-57 UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 7e-57 UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 7e-57 UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 8e-57 UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 1e-56 UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 2e-56 UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 2e-56 UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 2e-56 UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Pro... 221 2e-56 UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 4e-56 UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 4e-56 UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 219 7e-56 UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 219 7e-56 UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 2e-55 UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 217 2e-55 UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 217 2e-55 UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanae... 217 2e-55 UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winog... 217 2e-55 UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 217 3e-55 UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter... 217 4e-55 UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase s... 217 4e-55 UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase su... 216 5e-55 UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 5e-55 UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 6e-55 UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovi... 216 7e-55 UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfati... 215 8e-55 UniRef50_P72139 Putative imidazole glycerol phosphate synthase s... 215 1e-54 UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 215 2e-54 UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 2e-54 UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picr... 214 2e-54 UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 2e-54 UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 2e-54 UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 2e-54 UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 3e-54 UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 4e-54 UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 4e-54 UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase s... 213 4e-54 UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 7e-54 UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 1e-53 UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase su... 211 2e-53 UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 210 3e-53 UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 210 3e-53 UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hi... 210 4e-53 UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 209 6e-53 UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 209 7e-53 UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=... 208 1e-52 UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 2e-52 UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 2e-52 UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Pro... 207 3e-52 UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 207 4e-52 UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 207 5e-52 UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole ... 206 5e-52 UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole... 206 6e-52 UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobact... 206 6e-52 UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase s... 206 7e-52 UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 8e-52 UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria ... 205 9e-52 UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 205 1e-51 UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 205 1e-51 UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomyc... 205 2e-51 UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 2e-51 UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 2e-51 UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 2e-51 UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 2e-51 UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 2e-51 UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 3e-51 UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 204 3e-51 UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Pr... 203 3e-51 UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 203 4e-51 UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 202 7e-51 UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 202 1e-50 UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 202 1e-50 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 201 2e-50 UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 200 3e-50 UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase s... 200 4e-50 UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_Y... 200 5e-50 UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 200 5e-50 UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase su... 200 5e-50 UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxa... 199 6e-50 UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 199 6e-50 UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 199 6e-50 UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 198 1e-49 UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C... 198 1e-49 UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 198 2e-49 UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase su... 198 2e-49 UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 2e-49 UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 3e-49 UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 3e-49 UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 3e-49 UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 4e-49 UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 5e-49 UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 196 7e-49 UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 195 1e-48 UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 195 1e-48 UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 195 1e-48 UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 195 2e-48 UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine... 193 4e-48 UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 193 4e-48 UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxa... 193 4e-48 UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 193 7e-48 UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 192 1e-47 UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 192 1e-47 UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 192 1e-47 UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 190 3e-47 UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 190 4e-47 UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 190 4e-47 UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 189 6e-47 UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 189 7e-47 UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase s... 189 8e-47 UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxa... 189 8e-47 UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis... 189 1e-46 UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazol... 188 1e-46 UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 188 1e-46 UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 187 4e-46 UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 186 4e-46 UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 185 1e-45 UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovi... 185 1e-45 UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 185 2e-45 UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 184 2e-45 UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 184 3e-45 UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter... 183 4e-45 UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 183 6e-45 UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hi... 182 8e-45 UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 182 9e-45 UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes:... 182 1e-44 UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii H... 181 2e-44 UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacte... 181 2e-44 UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms Re... 181 2e-44 UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanae... 181 3e-44 UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collins... 180 3e-44 UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase su... 180 4e-44 UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 179 8e-44 UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hi... 176 4e-43 UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 176 5e-43 UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 176 6e-43 UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n... 174 3e-42 UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spir... 173 4e-42 UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 173 6e-42 UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogen... 171 1e-41 UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit Hi... 171 2e-41 UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID... 171 2e-41 UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase su... 170 3e-41 UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 170 6e-41 UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. ... 169 8e-41 UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxa... 168 1e-40 UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 168 1e-40 UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlo... 166 8e-40 UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase Hi... 165 1e-39 UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3... 164 3e-39 UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 163 4e-39 UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase s... 161 2e-38 UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 160 6e-38 UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=La... 159 7e-38 UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosyl... 155 1e-36 UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malasse... 155 2e-36 UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 153 6e-36 UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 152 9e-36 UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit H... 152 1e-35 UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxa... 150 5e-35 UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 148 2e-34 UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxa... 147 4e-34 UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlo... 146 5e-34 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 146 9e-34 UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicr... 145 1e-33 UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlo... 143 4e-33 UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oce... 142 1e-32 UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 141 2e-32 UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepI... 140 5e-32 UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanoco... 139 7e-32 UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 138 2e-31 UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococ... 137 3e-31 UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 137 3e-31 UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Me... 137 4e-31 UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirg... 134 3e-30 UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methano... 134 3e-30 UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planc... 133 4e-30 UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 133 5e-30 UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales... 131 2e-29 UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole ... 127 3e-28 UniRef50_Q1NTJ9 Histidine biosynthesis n=1 Tax=delta proteobacte... 126 9e-28 UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxa... 125 1e-27 UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxa... 125 1e-27 UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlo... 121 2e-26 UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methano... 121 3e-26 UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobial... 120 5e-26 UniRef50_Q603E0 Putative HisA/HisF family protein n=1 Tax=Methyl... 119 8e-26 UniRef50_Q2FS89 Histidine biosynthesis n=1 Tax=Methanospirillum ... 119 8e-26 UniRef50_D1JF95 Putative phosphoribosylformimino-5-aminoimidazol... 119 1e-25 UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanoco... 117 4e-25 UniRef50_B8EIK2 Histidine biosynthesis protein n=2 Tax=Beijerinc... 116 9e-25 UniRef50_Q1H0R8 Histidine biosynthesis n=1 Tax=Methylobacillus f... 115 2e-24 UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanoco... 114 2e-24 UniRef50_C0N3H2 Histidine biosynthesis protein n=1 Tax=Methyloph... 114 2e-24 UniRef50_C4ZG69 APG10 (Albino and pale green 10); 1-(5-phosphori... 113 8e-24 UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 T... 113 8e-24 UniRef50_B2JX56 Histidine biosynthesis protein n=6 Tax=Burkholde... 112 1e-23 UniRef50_D2QYD3 Histidine biosynthesis protein n=1 Tax=Pirellula... 111 2e-23 UniRef50_C6XDW4 Histidine biosynthesis protein n=1 Tax=Methylovo... 111 3e-23 Sequences not found previously or not previously below threshold: >UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hisF n=157 Tax=root RepID=HIS6_HELMI Length = 261 Score = 269 bits (688), Expect = 6e-71, Method: Composition-based stats. Identities = 121/257 (47%), Positives = 160/257 (62%), Gaps = 1/257 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV G+VVKG F N GD V LA Y +EGADE+VF DITASSDGR Sbjct: 1 MLAKRIIPCLDVHGGRVVKGTNFVNLRDAGDPVELAAVYDKEGADEVVFLDITASSDGRA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R AE + IPF V GG++S+ED ++L GADKIS+N+ A+ P LI+ A +F Sbjct: 61 IMLDVVRRTAEEVFIPFTVGGGLRSVEDIREMLKAGADKISLNTSAVQTPKLISDGAWKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G QCIVV ID + V + + T + L+W + V++ GAGEI+L M Sbjct: 121 GSQCIVVAIDARRRRDAEGNPVEGWEVYTHGGRKPTGIDVLEWARRVEELGAGEILLTSM 180 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG ++GYD+ + V E +P+IASGG G ++H +E D ALAAS+FH + Sbjct: 181 DKDGTKDGYDIPLTRAVSEAVTIPVIASGGVGNLDHIVEGLTVGKADAALAASIFHYREY 240 Query: 240 NIGELKAYLATQGVEIR 256 IGE K YL +GV +R Sbjct: 241 TIGETKEYLRERGVHVR 257 Score = 47.2 bits (111), Expect = 6e-04, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 37/112 (33%) Query: 21 VQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVA 80 D++ A+R E GA E++ + D V+E + IP + Sbjct: 149 THGGRKPTGIDVLEWARRVEELGAGEILLTSMDKDGTKDGYDIPLTRAVSEAVTIPVIAS 208 Query: 81 GGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTW 132 GG+ +L+ + L+ G ++ + + + V Sbjct: 209 GGVGNLDHIVEGLTVGKADAALAASIFHYREYTIGETKEYLRERGVHVRQWR 260 >UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hisF n=10 Tax=Bacteria RepID=HIS6_SULSY Length = 252 Score = 266 bits (681), Expect = 5e-70, Method: Composition-based stats. Identities = 121/257 (47%), Positives = 159/257 (61%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV G+VVKGV F N GD V +A Y +EGADELVF DITASS+ R Sbjct: 1 MLAKRIIPCLDVDKGRVVKGVNFVNLIDAGDPVEIASVYDKEGADELVFLDITASSEDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V + AE + +P V GG++SLED K+L GADK+SIN+ A+ +P+L+ A RF Sbjct: 61 IILDVVKKTAETVFMPLTVGGGVRSLEDIRKLLENGADKVSINTAAVKNPSLVENAAIRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVV ID E T + ++W + V+ GAGEI+L M+ Sbjct: 121 GSSTIVVAIDAKKVGENKW-----EVYIHGGRTPTGIDAIEWAKAVESLGAGEILLTSMD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG ++GYD+E K V E +P+IASGGAG ++HF EAF D LAAS+FH + I Sbjct: 176 KDGTKSGYDIELTKAVSEAVKIPVIASGGAGNVQHFYEAFEYGKADACLAASLFHFKEIE 235 Query: 241 IGELKAYLATQGVEIRI 257 I ELK YL +G+ +R+ Sbjct: 236 ISELKNYLKNKGINVRL 252 >UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=C7P985_METFA Length = 272 Score = 262 bits (670), Expect = 8e-69, Method: Composition-based stats. Identities = 114/272 (41%), Positives = 160/272 (58%), Gaps = 14/272 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIPCLD++DG+VVKG +F N GD V LA+ Y +EGADELVF DITAS++ R Sbjct: 1 MLTKRIIPCLDIKDGRVVKGTKFLNLRDAGDPVELAQLYDDEGADELVFLDITASAEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R AE + IP V GGIKS+ED KIL GADKISIN+ A+ +P LI ++ F Sbjct: 61 IIIDVVERTAEKVFIPLTVGGGIKSIEDFRKILRAGADKISINTAAVKNPNLIKEASEIF 120 Query: 121 GVQCIVVGIDTWY--------------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEV 166 G QC+VV ID + + + T + ++W ++V Sbjct: 121 GSQCVVVAIDAKRHYINEDEIDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKV 180 Query: 167 QKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD 226 ++ GAGEI+L +++DG ++GYDL +++ + +P+IASGG G EH EAF D Sbjct: 181 EELGAGEILLTSIDKDGTKSGYDLILTREISKSVKLPVIASGGCGKPEHVYEAFVHGKAD 240 Query: 227 GALAASVFHKQIINIGELKAYLATQGVEIRIC 258 AL A + H + I E+K Y A +G+ +R+ Sbjct: 241 AALMAGILHYKEYTIEEIKKYCADRGIPMRLL 272 >UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hisF n=28 Tax=Bacteria RepID=HIS6_EXISA Length = 255 Score = 261 bits (667), Expect = 2e-68, Method: Composition-based stats. Identities = 120/258 (46%), Positives = 165/258 (63%), Gaps = 8/258 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML +RIIPCLDV++G+VVKG++F IGD V +AK Y E GADELVF DITAS++ R Sbjct: 1 MLKRRIIPCLDVKEGRVVKGIEFVQLRDIGDPVEIAKYYDESGADELVFLDITASTERRQ 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VS VA + IP V GGI+SLED + +L GADK+S+N+ A+ P+LI ADRF Sbjct: 61 TMLDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID + + G+Y+V Y + T ++W ++V GAGE+++ MN Sbjct: 121 GSQCIVVAIDVKF--KDGEYYVYTY----GGKQKTDLLAVEWAKQVAALGAGELLVTSMN 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 QDG ++GYDL L+++REV +P+IASGGAG EH +EA VD AL AS+ H + Sbjct: 175 QDGKQSGYDLSILEQLREVVDIPIIASGGAGNAEHVVEALEK--VDAALLASILHDRKTT 232 Query: 241 IGELKAYLATQGVEIRIC 258 + E+K + + +R Sbjct: 233 VEEVKHVCKSHNLPMRFV 250 >UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hisF n=27 Tax=cellular organisms RepID=HIS6_META3 Length = 275 Score = 260 bits (664), Expect = 5e-68, Method: Composition-based stats. Identities = 101/275 (36%), Positives = 152/275 (55%), Gaps = 18/275 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIPCLD+++G+VVKG F GD V L+K Y E+GADELVF DI AS + R Sbjct: 1 MLTKRIIPCLDIKNGRVVKGTNFVELRDAGDPVELSKIYNEQGADELVFLDIGASHEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V + A+ + IP V GGI++ +D +IL GADKIS+N+ A+ +P LI + ++ + Sbjct: 61 IIEHLVEKTADQVFIPLTVGGGIRTTDDFRRILRAGADKISVNTAAIHNPDLIKQSSELY 120 Query: 121 GVQCIVVGIDTWY------------------DAETGKYHVNQYTGDESRTRVTQWETLDW 162 G QC+VV ID+ + + T + ++W Sbjct: 121 GAQCVVVAIDSKRHYVNEEDLDSKQLEDKNVVKVDKNKYCWFEVFIYGGRKETGIDAIEW 180 Query: 163 VQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRD 222 + ++ GAGEI+L M+ DG ++GYD+E K + +P+IASGG G +H + F Sbjct: 181 AKTAEELGAGEILLTSMDADGTKDGYDIELTKSISTHIKLPVIASGGCGAPQHIHQVFEY 240 Query: 223 ADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D AL AS+ H + +GELK Y + + +R+ Sbjct: 241 GKADAALMASILHYREYTVGELKKYCMDKNIPMRL 275 >UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW6_9FIRM Length = 252 Score = 259 bits (661), Expect = 9e-68, Method: Composition-based stats. Identities = 114/257 (44%), Positives = 156/257 (60%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M KRIIPCLDV+DG+VVKG F GD V LA RY EE ADELVF DITASSD R Sbjct: 1 MYTKRIIPCLDVKDGRVVKGTNFVGLRDAGDPVELAARYDEERADELVFLDITASSDNRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + A + IPF V GGI+++ED ++L GADK S+N+ A+ +P L+ A++F Sbjct: 61 TMVNVARDCASKVFIPFTVGGGIRTVEDMRRMLKAGADKTSLNTAAVKNPGLLKEGAEKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ +D A ++ V T + L+WV++ GAGEI+L M+ Sbjct: 121 GRQCMVLAVDARR-AGNHRWEVY----VNGGRTPTGLDCLEWVKKAVALGAGEILLTSMD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG ++GYD+E + V + +VP+IASGGAG +EHF + D LAASVFH Sbjct: 176 ADGTKDGYDIELTRAVSDAVNVPVIASGGAGKLEHFYDVLTLGHADAVLAASVFHYGQFT 235 Query: 241 IGELKAYLATQGVEIRI 257 + ++K YL ++GVE+R Sbjct: 236 VRQVKEYLQSRGVEVRF 252 >UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hisF n=354 Tax=cellular organisms RepID=HIS6_METBU Length = 273 Score = 258 bits (659), Expect = 2e-67, Method: Composition-based stats. Identities = 110/273 (40%), Positives = 152/273 (55%), Gaps = 16/273 (5%) Query: 1 MLAKRIIPCLDV----RDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 ML KRIIPCLDV G VVKGV+F + + GD V LAKRY E+GADELVF DITAS Sbjct: 1 MLTKRIIPCLDVTLDASGGTVVKGVEFVDLKKAGDPVDLAKRYNEQGADELVFLDITASH 60 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 +GR + R A + IP V GGI S+ED +IL GADK+S+N+ A+ +P I Sbjct: 61 EGRSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREA 120 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQ------------YTGDESRTRVTQWETLDWVQ 164 ++ FG QCIV ID + + T +T+ W + Sbjct: 121 SNIFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIYGGREPTGLDTVQWAK 180 Query: 165 EVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD 224 +V++ G+GEI+L MN+DG +G+D+ KK+ E +P+IASGG G EH + F D Sbjct: 181 KVEELGSGEILLTSMNRDGTYDGFDIPITKKLSEELDIPIIASGGVGNPEHMYKGFVDGK 240 Query: 225 VDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 D LAAS+FH + ++K L + + +R+ Sbjct: 241 ADAGLAASIFHFGEYTVRDVKEALRAKNIPVRL 273 >UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hisF n=224 Tax=Bacteria RepID=HIS6_STACT Length = 254 Score = 252 bits (645), Expect = 6e-66, Method: Composition-based stats. Identities = 106/256 (41%), Positives = 160/256 (62%), Gaps = 4/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ KRIIPCLDV+DG+VVKGVQF+ IGD V LA Y E ADELVF DI+ + +G Sbjct: 1 MIKKRIIPCLDVKDGRVVKGVQFKGLRDIGDPVALAAYYNAELADELVFLDISRTENGHQ 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + A + IP + GGI S +D + +L GADK+S+NS AL +P+L+ +++F Sbjct: 61 MMLDIIEETASKLFIPLTIGGGISSTDDISTLLKHGADKVSLNSSALRNPSLVKEASEKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI + +D ++ E + + + T LDWV++V+ GAGE+++ M+ Sbjct: 121 GSQCICIAVDAKWEDERNDWFCYTH----GGKQPTDIRVLDWVRQVEYLGAGELLVTSMD 176 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV+ G+D + L ++ V +P+IASGG G +HF++ F+ +V LAAS+FH + Sbjct: 177 YDGVKQGFDHQLLNQINTVVSIPVIASGGGGNAQHFVDLFQQTNVSAGLAASIFHDKETT 236 Query: 241 IGELKAYLATQGVEIR 256 IG +K YL +GV++R Sbjct: 237 IGAVKTYLKDKGVDVR 252 >UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=HIS6_THEYD Length = 278 Score = 249 bits (637), Expect = 5e-65, Method: Composition-based stats. Identities = 119/278 (42%), Positives = 161/278 (57%), Gaps = 21/278 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV+DG+VVKGV F N GD V A Y EE ADELVF D+TAS + R Sbjct: 1 MLAKRIIPCLDVKDGRVVKGVNFLNLRDAGDPVENALYYNEEEADELVFLDVTASHEKRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R A V+ +P V GGIKSL+D +L+ GADK+SIN+ A+ DP I + + RF Sbjct: 61 IIIDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRF 120 Query: 121 GVQCIVVGIDTWYDAET---------------------GKYHVNQYTGDESRTRVTQWET 159 G QCIV+ ID + K + + Sbjct: 121 GSQCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRPIDA 180 Query: 160 LDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA 219 + W +++++ GAGEI+L M++DG + GYD+E + + E +P+IASGGAGT+EH EA Sbjct: 181 IAWAKKMEEFGAGEILLTSMDRDGTKEGYDIELTRAISEAVSIPVIASGGAGTLEHLYEA 240 Query: 220 FRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 F A D ALAAS+FH + +I E K +L +G+ +RI Sbjct: 241 FAYAKADAALAASIFHFREYSIREAKEFLRQKGIPVRI 278 >UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hisF n=55 Tax=cellular organisms RepID=HIS6_THEEB Length = 281 Score = 246 bits (629), Expect = 5e-64, Method: Composition-based stats. Identities = 111/256 (43%), Positives = 149/256 (58%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRI+PCLDV+ G+VVKGV F N GD V LA+ Y GADELVF DITA+ + R Sbjct: 2 MLAKRILPCLDVKAGRVVKGVNFVNLRDAGDPVELAQAYNAAGADELVFLDITATHEERN 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V R A+ + IP V GGI+SL +L GADK+S+NS A+ P L+ + +DRF Sbjct: 62 ILIDVVYRTADQVFIPLTVGGGIQSLTMIKDLLRAGADKVSLNSAAVRQPDLVNQASDRF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID + + T + + W E+ KRGAGE+++ M+ Sbjct: 122 GAQCIVVAIDARREPDCAPDQPRWQVYVRGGREATGLDAVAWAVEMAKRGAGELLVTSMD 181 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + GYDLE + + E +P+IASGGAGT EH A + + AL AS+ H + Sbjct: 182 ADGTQAGYDLELTRAIAERVEIPVIASGGAGTCEHIRAALVEGKAEAALLASLLHYGQLT 241 Query: 241 IGELKAYLATQGVEIR 256 I ++K YL V +R Sbjct: 242 IAQIKGYLHQHQVPVR 257 >UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hisF n=19 Tax=cellular organisms RepID=HIS6_DESAA Length = 260 Score = 243 bits (621), Expect = 4e-63, Method: Composition-based stats. Identities = 111/256 (43%), Positives = 157/256 (61%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML+KR+I CLDVRDG+ KG++F+ + IGD V +A+ Y E G DELVFYDITAS + R Sbjct: 1 MLSKRVIVCLDVRDGKTTKGIKFKGNVDIGDPVDMARVYYEAGCDELVFYDITASHEKRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V RVAE I IPF V GGI S+ED +L GA+KIS+NS A+ +P +IT+ A+ F Sbjct: 61 IMIDVVRRVAETIFIPFSVGGGISSVEDMRDVLLAGAEKISVNSAAVKNPKIITQGAEAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+G+D ++ K + L W QE ++ GAGEI LN ++ Sbjct: 121 GNQCVVLGMDVKKVEKSEKIPSGYEIVINGGRTYMGIDALWWAQEGERLGAGEICLNSID 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + GY+LE + E ++P+IASGG G +H + ++ D AL AS+ H Sbjct: 181 ADGTKEGYELELTALISENVNIPVIASGGGGIPQHLGDVLKEGKADAALIASMVHYGTYT 240 Query: 241 IGELKAYLATQGVEIR 256 I E+K +L +QG+ +R Sbjct: 241 IPEIKDHLKSQGISVR 256 >UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hisF n=36 Tax=cellular organisms RepID=HIS6_HALWD Length = 270 Score = 241 bits (616), Expect = 2e-62, Method: Composition-based stats. Identities = 111/269 (41%), Positives = 144/269 (53%), Gaps = 13/269 (4%) Query: 1 MLAKRIIPCLDVR---DGQ--VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITAS 55 ML KRIIPC+DV DG V G+ F + E GD V +AK+Y GADE VF DITAS Sbjct: 1 MLTKRIIPCIDVDLDEDGNPAVYTGINFEDLEYTGDPVEMAKQYNMAGADEFVFLDITAS 60 Query: 56 SDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + GR VSRVA+ I IP V GGI++ +D L GADK+SIN+ AL P LIT Sbjct: 61 AVGRETMLETVSRVADEIFIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALETPELITT 120 Query: 116 LADRFGVQCIVVGIDTWYDAETG--------KYHVNQYTGDESRTRVTQWETLDWVQEVQ 167 A FG QCIV+ +D + + T + L+WV E + Sbjct: 121 GASAFGSQCIVISVDARRRFDEQGENYLSVDGESCWFECTVKGGREGTGIDVLEWVTEAE 180 Query: 168 KRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDG 227 RGAGE+ +N ++ DG ++GYD+ V + P+IAS G G+ E F +A D Sbjct: 181 TRGAGELFINSIDADGTQDGYDIPLTSAVCDAVSTPVIASSGCGSPADMHEVFTEAGADA 240 Query: 228 ALAASVFHKQIINIGELKAYLATQGVEIR 256 LAAS+FH +I K YL +GV IR Sbjct: 241 GLAASIFHFGEYSIEATKEYLDERGVPIR 269 >UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hisF n=420 Tax=cellular organisms RepID=HIS6_BRUMB Length = 261 Score = 241 bits (615), Expect = 2e-62, Method: Composition-based stats. Identities = 108/256 (42%), Positives = 150/256 (58%), Gaps = 1/256 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L R+IPCLDV+DG+VVKGV F + GD V A+ Y GADEL F DITASSD R Sbjct: 3 LKARVIPCLDVKDGRVVKGVNFVDLIDAGDPVEAARAYDAAGADELCFLDITASSDNRET 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+R AE +P V GG++ + D K+L GADK+SIN+ A+ +P + AD+FG Sbjct: 63 IFDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QCIVV ID + G+ + + T + +++ Q+V GAGEI+L M++ Sbjct: 123 NQCIVVAIDAKKVSGAGEND-HWEIFTHGGRQPTGIDAVEFAQKVVDLGAGEILLTSMDR 181 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG + GYD+ + V + P+IASGG GT++H + RD LAAS+FH I Sbjct: 182 DGTKAGYDVALTRAVADSVRAPVIASGGVGTLDHLVAGIRDGHATAVLAASIFHFGTYTI 241 Query: 242 GELKAYLATQGVEIRI 257 GE K Y+A G+ +R+ Sbjct: 242 GEAKRYMAEAGIPMRL 257 >UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC 17748 RepID=C4FS06_9FIRM Length = 256 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 102/256 (39%), Positives = 158/256 (61%), Gaps = 1/256 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCL V +G+V GVQFR+ GD V A+RY +GADELV DITA+++ R Sbjct: 1 MLAKRIIPCLGVANGRVQNGVQFRDMVDAGDPVECAERYEIQGADELVLLDITATTEARK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V ++ + +P V GGI S+ED +++ GADK+SIN+ AL++P+LIT A +F Sbjct: 61 TFTDIVLNASDKVFMPLTVGGGITSVEDMTQLMKAGADKVSINTAALSNPSLITEGAKKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D Y+ ++ + G + L+W +E RGAGE+++ ++ Sbjct: 121 GNQGIVVCLDVKYNPFEKMWYAYGH-GTSNDPGAQCKNALEWAKEAVDRGAGELLVTSID 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 + G G+D+E + + EV VP+ A GGAG ++HF++ F +V GALA+++ H +++ Sbjct: 180 RHGTGLGFDIELYQALAEVVDVPVTAFGGAGNIQHFVDLFTKTNVTGALASALLHNKVLT 239 Query: 241 IGELKAYLATQGVEIR 256 I ++K L G+ +R Sbjct: 240 IKDIKKALHAAGIVVR 255 >UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococcoides RepID=A5FQU7_DEHSB Length = 268 Score = 238 bits (609), Expect = 9e-62, Method: Composition-based stats. Identities = 90/257 (35%), Positives = 140/257 (54%), Gaps = 1/257 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M +IIPCLDV+DG+VVK ++F + D A Y+++GADEL F DITA+ + Sbjct: 1 MKPIKIIPCLDVKDGRVVKEIKFTDMADARDPAEAAFVYSKQGADELAFLDITATIENSS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + WV ++ +P GGI++L+D + + G +++N+ + I + RF Sbjct: 61 IHTDWVKKIISKTSLPLIAGGGIRNLQDIENLFTLGVSNVALNTITPQNQEFIRKAVARF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I+V ID + H T + E +DW ++V+ GAG I+L + Sbjct: 121 GSERIIVAIDGIKNPPGNG-HPRLETVMPNGDDTHNLELVDWAKQVEALGAGAILLTSKD 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG ++G+D+E ++ V +P+IASGGAG +E A + LAASVFH IIN Sbjct: 180 TDGTKDGFDMEMIRSVTRAVSIPVIASGGAGKLEDMYAAIIEGKAQAVLAASVFHSGIIN 239 Query: 241 IGELKAYLATQGVEIRI 257 I ELK YL ++G+ + I Sbjct: 240 ISELKTYLHSKGIPVNI 256 >UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Bacteria RepID=HIS4_LISW6 Length = 240 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 67/246 (27%), Positives = 117/246 (47%), Gaps = 15/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D+++GQ V+ Q + + D + AK +A GA L D+ + +GR Sbjct: 1 MQIFPAIDLKNGQCVRLFQGDFSKKMIVNEDPIAQAKAFATGGATYLHIVDLDGALEGRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + ++ E +P V GGI+SL L G D++ I S AL +P + ++ Sbjct: 61 VNLEIIQKMKEAATVPVQVGGGIRSLAQVDYYLDSGIDRVIIGSAALTNPDFLHAAVQKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I VGID N Y V+Q LD ++++K G I+ ++ Sbjct: 121 GPK-IAVGIDAK----------NGYVATSGWLEVSQVNYLDLAKQMEKVGVETIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G +LEQ+ +++ ++ LIASGG + EA + GA+A + I+ Sbjct: 170 RDGTLTGPNLEQMAALQKHVNIHLIASGGVSSRADL-EALSQLGLYGAIAGKALYNGHIS 228 Query: 241 IGELKA 246 + ++ Sbjct: 229 MSDVTE 234 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 237 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 61/244 (25%), Positives = 114/244 (46%), Gaps = 14/244 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 R+ P +DV+DGQ V+ + +AK + E GA + D+ + G Sbjct: 1 MRLYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + ++ +++P + GGI++LE+ ++L G ++ I + A+ +P I DRF Sbjct: 61 VNAETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IVVG+D + E +V+ L ++ G IV ++ Sbjct: 121 GAEHIVVGVDAK----------DGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDIS 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G ++EQ K + + + +IASGG M+ DA + GA+ +++ I+ Sbjct: 171 KDGMLAGPNVEQTKILSDKTGIDIIASGGMSCMDDLTH-INDAGIHGAIIGKAIYEKRID 229 Query: 241 IGEL 244 + E Sbjct: 230 LKEA 233 Score = 61.4 bits (148), Expect = 3e-08, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 41/114 (35%), Gaps = 1/114 (0%) Query: 142 VNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCH 201 V G + V + + ++ GA I ++ +G + E +KK+ + Sbjct: 15 VRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVNAETIKKICSSVN 74 Query: 202 VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEI 255 VP+ GG T+E+ E D V + + + I + + + Sbjct: 75 VPVQMGGGIRTLENIQEVL-DLGVYRVIIGTKAVENPDFIKAAIDRFGAEHIVV 127 Score = 45.6 bits (107), Expect = 0.001, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 37/114 (32%), Gaps = 2/114 (1%) Query: 10 LDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRV 69 +D +DG V ++ + LA + G +V+ DI+ + + Sbjct: 129 VDAKDGLV--AIEGWEKVSDKTALSLALAMKDIGVQTIVYTDISKDGMLAGPNVEQTKIL 186 Query: 70 AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ I +GG+ ++D I G I + + F Sbjct: 187 SDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNLFESG 240 >UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hisF n=360 Tax=Bacteria RepID=HIS6_XANOM Length = 258 Score = 237 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 163/256 (63%), Positives = 197/256 (76%), Gaps = 1/256 (0%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML++RIIPCLDVR+G+VVKGV+F +H +GDIV LA RY +GADELVFYDI AS +GR Sbjct: 1 MLSRRIIPCLDVRNGRVVKGVKFHDHIDMGDIVELALRYRAQGADELVFYDIGASPEGRS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VD +WV RVA +IDIPFCVAGGI +E A +L GADKISINSPAL P LI+ LAD F Sbjct: 61 VDYTWVERVARLIDIPFCVAGGIGDVETARAVLHAGADKISINSPALGRPQLISELADAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 GVQC+VVGID+ + + G++ V +YTGD S+T+ TLDWV E Q+ GAGEIVLN M+ Sbjct: 121 GVQCVVVGIDSIRE-DDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMD 179 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGVR GYD+ QL++VR +CHVPLIASGGAG M+HF + F ADVDGALAASVFH I Sbjct: 180 NDGVRRGYDIAQLRQVRALCHVPLIASGGAGEMQHFADVFDQADVDGALAASVFHSGAIP 239 Query: 241 IGELKAYLATQGVEIR 256 I ELK +L Q +E+R Sbjct: 240 IPELKQFLRAQQIEVR 255 >UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Halothermothrix orenii H 168 RepID=HIS4_HALOH Length = 237 Score = 236 bits (603), Expect = 6e-61, Method: Composition-based stats. Identities = 61/247 (24%), Positives = 109/247 (44%), Gaps = 14/247 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++DG V+ + V +A + + GA L D+ + G Sbjct: 1 MEVIPAVDIKDGSCVRLKKGDFNKRRVYSTSPVDVALYWEKHGASRLHIVDLDGAKSGWP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + +A ++IP V GGI+SL+ K L G D+I + + AL +P L+ R D F Sbjct: 61 THLKTIREIALRVNIPLQVGGGIRSLKVIKKYLDSGVDRIILGTVALKNPELVKRALDNF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVVG+D E + +Q D + E+++ G + +N Sbjct: 121 GSNRIVVGVDAR----------GGKVATEGWLKTSQVTVEDIISEMEEVGVKTFIYTDIN 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G D+E +K+V + +IASGG + + + + + A+ ++ + Sbjct: 171 RDGMLKGPDIEGIKRVLKSTKARIIASGGISSRQDLIN-LKAIGIKAAIVGKALYEGNLP 229 Query: 241 IGELKAY 247 + L Y Sbjct: 230 LEVLNQY 236 >UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hisF n=67 Tax=Bacteria RepID=HIS6_SYNY3 Length = 261 Score = 235 bits (601), Expect = 9e-61, Method: Composition-based stats. Identities = 114/255 (44%), Positives = 152/255 (59%), Gaps = 2/255 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LAKRI+PCLDV G+VVKG+ F + + GD V LA+ Y E GADELVF DITA+ + R Sbjct: 3 LAKRILPCLDVNAGRVVKGINFVDLQDAGDPVELARAYNEAGADELVFLDITATHEQRDT 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R AE + IP V GGI +LE +L GADK+S+NS A+ DP I+R +DRFG Sbjct: 63 IIDVVYRTAEEVFIPLTVGGGISTLEHIKNLLRAGADKVSVNSSAVRDPDFISRASDRFG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QCIVV ID + + Y T + + W +EV KRGAGE+++ M+ Sbjct: 123 RQCIVVAIDARRRLDADNPGWDVYV--RGGRENTGLDAIAWAEEVAKRGAGELLVTSMDG 180 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG + GYDL + E +P+IASGGAG +H EAF + + AL AS+ H + I Sbjct: 181 DGTQAGYDLALTAAIAERVEIPVIASGGAGNCQHVYEAFTEGKAEAALLASLLHYGQLTI 240 Query: 242 GELKAYLATQGVEIR 256 GELK +L + + +R Sbjct: 241 GELKTFLEARQIPVR 255 >UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKR3_FIBSS Length = 263 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 103/256 (40%), Positives = 152/256 (59%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+I CLDVR+ +V KGV+F+ + IGD V + RY++EG DELVFYDITAS++ R Sbjct: 1 MLTKRLIVCLDVRNRKVTKGVKFKGNIDIGDPVEMGARYSDEGVDELVFYDITASAENRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + ++A+ + IPF V GGI++L+D + L GA+K+S+NS A+ P +I A F Sbjct: 61 CDMEMIRQIAKRVFIPFAVGGGIRNLDDMHEALLAGAEKVSVNSLAVLHPEIIAEGAKAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV+G+D + + K + + L W + ++ G GEI LN ++ Sbjct: 121 GRQCIVLGMDAKFVGVSDKIPSGYEVFIRGGRQAMGIDALQWAKRAEELGVGEICLNSID 180 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV+NGY+L + + VP+IASGGAGT H ++ FR D AL AS+ H Sbjct: 181 TDGVKNGYELTITDMIAKAVQVPVIASGGAGTPAHIVDLFRKTSADAALVASMVHFGDYT 240 Query: 241 IGELKAYLATQGVEIR 256 + +K + G+ +R Sbjct: 241 VPGIKGEMLAAGIPVR 256 >UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M910_CALMQ Length = 254 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 112/256 (43%), Positives = 154/256 (60%), Gaps = 8/256 (3%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L +RIIPC+DV VVKGV F ++GD V LA RY EEGADEL DITA+ GR Sbjct: 7 LVRRIIPCMDVDADIVVKGVNFEGLRVMGDPVELASRYEEEGADELFLLDITATVQGRST 66 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V VA + IP V GGI+ +EDA GADK+SIN+ A+ DP+++ +L+ +G Sbjct: 67 FLETVRNVAAAVSIPLGVGGGIRGMEDADAAFKAGADKVSINTAAVKDPSIVAKLSREYG 126 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q +VV IDT + + R T +DW + V++ GAGE+++ ++ Sbjct: 127 SQSVVVAIDTRRINNEWRVFIMG------GRRETLLNAVDWARTVEELGAGELLVTSIDA 180 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG R GYD+E +++ + ++P+IASGGAG HFLE + D ALAASVFH +INI Sbjct: 181 DGTRAGYDIELYRRLADAVNIPVIASGGAGEPSHFLEVLKY--ADAALAASVFHMGVINI 238 Query: 242 GELKAYLATQGVEIRI 257 LKAYL+ G+ +RI Sbjct: 239 SILKAYLSELGIRVRI 254 >UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Thauera sp. MZ1T RepID=C4ZLR4_THASP Length = 226 Score = 235 bits (599), Expect = 1e-60, Method: Composition-based stats. Identities = 95/257 (36%), Positives = 139/257 (54%), Gaps = 31/257 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRIIPCLDV+ G+VVKGV F GD V +A+RY E+ Sbjct: 1 MLAKRIIPCLDVKSGRVVKGVNFVELRDAGDPVEIARRYDEQ------------------ 42 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VAE + IP V GG++ +ED ++L+ GADK+S+N+ A+ +P L+ A + Sbjct: 43 --------VAEQVFIPLTVGGGVRVVEDVRRLLNAGADKVSMNTAAVNNPQLVFEAASKV 94 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIVV ID A T + ++W ++V+ GAGEI+L M+ Sbjct: 95 GSQCIVVAIDAKQTAPGKW-----EVFTHGGRNNTGLDAIEWARKVESLGAGEILLTSMD 149 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG ++G+DL + V + +P+IASGG GT+EH E + D LAAS+FH Sbjct: 150 RDGTKSGFDLALTRAVSDAVRIPVIASGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHT 209 Query: 241 IGELKAYLATQGVEIRI 257 + E K + +G+E+R+ Sbjct: 210 VREAKELMRARGIEVRL 226 >UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SCV5_HAHCH Length = 255 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 94/260 (36%), Positives = 149/260 (57%), Gaps = 8/260 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KRIIP L + G++VKG QF GD V A+ Y + ADELVF D+ A+ G Sbjct: 1 MLKKRIIPMLLLSQGRMVKGKQFSAFRDTGDPVSAARIYNAQFADELVFLDVDANRQGSD 60 Query: 61 --VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + +V+ +P V GG+ S+E +++ GADK+ I + AL +P LI + Sbjct: 61 FEQLLNLIDKVSSECFMPLSVGGGVNSVEQVRRLVQSGADKVVITTAALENPGLINDASA 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG QCIVVG+D E G Y + + G T+ E ++++++ +RGAGE ++N Sbjct: 121 IFGRQCIVVGLDVKR--EDGAYRLYSHCG----RHKTERELEEFIRDMTQRGAGEFIVNA 174 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 +++DG+ GYDLE +K + V P++A+GGAGT H AF++A+ D + AS+FH Sbjct: 175 VDRDGMMQGYDLEMIKCAKAVTDRPVLAAGGAGTFAHLTAAFQEANADAVVCASIFHFGD 234 Query: 239 INIGELKAYLATQGVEIRIC 258 N +++L G+ +++ Sbjct: 235 NNPIRARSHLLNAGIPMKLI 254 >UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PWX6_9BACT Length = 243 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 62/250 (24%), Positives = 117/250 (46%), Gaps = 15/250 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D++ G+ V+ Q + E D V +AK + ++GA L D+ + DG Sbjct: 1 MIIFPAIDLKGGKCVRLTQGKKDEETVFSDDPVDMAKSWEDQGAQYLHVVDLDGAFDGLP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + S V ++ I+IP GG+++ E +L G +++ I + AL P+ + L F Sbjct: 61 KNLSIVEQIVNNINIPIEFGGGLRTTESVKSVLDLGVERVIIGTKALDSPSWVEELCSLF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + V DA+ GK V+ + T +++ +D+ +E++K I+ ++ Sbjct: 121 PGRVAVG-----IDAKNGKVAVHGW------TSLSEKTAIDFAREMEKFSPCAIIFTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G ++E LK++ P+IASGG +++ E V+G + + I Sbjct: 170 KDGMLQGPNIESLKELLSSIKTPVIASGGISSLKDI-EYICQLPVEGMIVGKALYTGHIK 228 Query: 241 IGELKAYLAT 250 E K + Sbjct: 229 FSEAKQLCDS 238 Score = 51.8 bits (123), Expect = 2e-05, Method: Composition-based stats. Identities = 18/116 (15%), Positives = 39/116 (33%), Gaps = 2/116 (1%) Query: 10 LDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRV 69 +D ++G+V V + A+ + ++F DI+ + + + + Sbjct: 128 IDAKNGKV--AVHGWTSLSEKTAIDFAREMEKFSPCAIIFTDISKDGMLQGPNIESLKEL 185 Query: 70 AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCI 125 I P +GGI SL+D I + + + + C+ Sbjct: 186 LSSIKTPVIASGGISSLKDIEYICQLPVEGMIVGKALYTGHIKFSEAKQLCDSICL 241 >UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI6_KANKD Length = 265 Score = 232 bits (593), Expect = 7e-60, Method: Composition-based stats. Identities = 104/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L R+I CLDV G+VVKGV F+ + +GD V LA RY E+GADE++F DI A+ + R Sbjct: 5 LKSRVIVCLDVAHGRVVKGVNFKGLQDMGDPVELAIRYQEQGADEIIFLDIKATLEQRAN 64 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V+RVAE + IPF V GG+ + D A+ L+ GADK+++NS A+ P L+ +A FG Sbjct: 65 ALEVVTRVAENLSIPFTVGGGLNTYADVAQFLNAGADKVALNSAAVKHPDLVDEIAKGFG 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 QC+VV +D + + ++Y +T + W+ E+++RGAGEI+L M+ Sbjct: 125 SQCVVVAVDLNQEQDQKTQGSSEYEVYINGGHTLTDLNAMQWLTEIEQRGAGEILLTAMH 184 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G+D E + +V + + +IASGGA HF + F A D ALAA +FH+ Sbjct: 185 RDGTGFGFDNELMSQVSKKLGIQVIASGGASKPAHFTDTF-LAGSDAALAAGMFHRGEFT 243 Query: 241 IGELKAYLATQGVEIRI 257 +G++K L GV +RI Sbjct: 244 VGQVKQELLNNGVAVRI 260 >UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=15 Tax=root RepID=HIS4_DEHSC Length = 244 Score = 232 bits (592), Expect = 9e-60, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 110/250 (44%), Gaps = 15/250 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 IIP +D+ G+ V+ Q D V A R+ GA L D+ ++DG+ Sbjct: 7 KIEIIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQ 66 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V+ + +A IP V GGI+S+E K+L G D++ + + A+ +P L+ + R Sbjct: 67 SVNFELIKEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICAR 126 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 + V DA GK + T+ + L+ + ++K G + + Sbjct: 127 YADSVAV-----SIDARNGKVATRGWV------TNTEIDALELARSMKKLGIRRFIYTDI 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG + + ++ + +VP+IASGG ++ H +D +GA+ + + Sbjct: 176 SRDGTLSEPNFAAIRDLISAINVPVIASGGVSSLSHL-RLLKDIGAEGAIVGKAIYTGDL 234 Query: 240 NIGELKAYLA 249 N+ L+ Sbjct: 235 NLKRAFEDLS 244 >UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_THEYD Length = 244 Score = 232 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 117/253 (46%), Gaps = 14/253 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IIP +D++DG+ V+ Q + E + A R+ EGA+ L D+ + +G++ Sbjct: 1 MQIIPAIDLKDGKCVRLRQGKFSEVTVYYDNPEDAALRWQNEGAEVLHVVDLDGAKEGKI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ E V GGI+ +ED +LS G D++ + + A+ P + + RF Sbjct: 61 GNLPSIKKIREAFRGNIEVGGGIRRIEDIELLLSVGIDRVIVGTIAVQSPDFVKEVCKRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + IV DA+ G V + VT+ ++ ++Q G I+ ++ Sbjct: 121 PKKIIVG-----IDAKDGLVAVKGWV------EVTEIRAIELALKMQDYGIWGIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G ++E K + E VP+IASGG ++E + + G + + I+ Sbjct: 170 RDGMLTGPNIEATKALVESVKVPVIASGGVSSIEDIRKLAEIPQLWGVITGKAIYSGAID 229 Query: 241 IGELKAYLATQGV 253 + E + GV Sbjct: 230 LKEALRIIKGDGV 242 >UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hisF n=7 Tax=cellular organisms RepID=HIS6_THEP1 Length = 254 Score = 232 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 129/257 (50%), Positives = 167/257 (64%), Gaps = 7/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRII CLDV+DG+VVKG F N GD V L K Y+E G DELVF DITAS + R Sbjct: 1 MLAKRIIACLDVKDGRVVKGTNFENLRDSGDPVELGKFYSEIGIDELVFLDITASVEKRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V +VAE IDIPF V GGI E A++++ GADK+SIN+ A+ DP+LIT++A F Sbjct: 61 TMLELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVEDPSLITKIARTF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV ID G++ V Y+G ++ T DWV EV++RGAGEI+L ++ Sbjct: 121 GSQAVVVAIDAKKV--DGEFVVFTYSGKKN----TGILLRDWVVEVERRGAGEILLTSID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + GYD E ++ VR + +P+IASGGAG MEHFLEAF A SVFH + I+ Sbjct: 175 RDGTKAGYDTEMIRFVRPLTTLPIIASGGAGKMEHFLEAFLAGADAALAA-SVFHFREID 233 Query: 241 IGELKAYLATQGVEIRI 257 + ELK YL GV +R+ Sbjct: 234 VRELKEYLKKHGVNVRL 250 >UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hisF n=3 Tax=Bacteria RepID=C8PKX5_9PROT Length = 306 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 123/304 (40%), Positives = 162/304 (53%), Gaps = 51/304 (16%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 AKRIIPCLDV+DG+VVKGV F GD V +AKRY EEGADEL F DITAS GR Sbjct: 5 AKRIIPCLDVKDGRVVKGVNFVGLVDAGDPVEIAKRYNEEGADELCFLDITASHLGRDTI 64 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V RVA + IP V GGI++++D +++L+ G DKIS+NS A+ +P LI A++FG Sbjct: 65 VDVVERVARELFIPLTVGGGIRTIDDISRLLNVGCDKISLNSAAIKNPNLIDEAANKFGS 124 Query: 123 QCIVVGIDTWYDAE---------------------------------------------- 136 QC+V+ ID ++ Sbjct: 125 QCVVIAIDAKRNSIEISRGDLYGEARNSNGDLHGGMRNPDTNLGSEARNFGEILRGAQDE 184 Query: 137 ---TGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQL 193 T + L W +E Q+RGAGEI+L M+ DGV+NG++L Sbjct: 185 ILTGNGELCGYSVFINGGRLDTGRDALAWAKEAQERGAGEILLTSMDCDGVKNGFELNLT 244 Query: 194 KKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGV 253 + + +P+IASGGAG MEHF +AF A D LAAS+FH + I I LKAYL QG+ Sbjct: 245 R-IFSALDIPVIASGGAGKMEHFKDAF-LAGADACLAASIFHFREIEIKALKAYLQEQGI 302 Query: 254 EIRI 257 E+R+ Sbjct: 303 EVRL 306 >UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Bacillales RepID=HIS4_BREBN Length = 249 Score = 231 bits (589), Expect = 2e-59, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 103/255 (40%), Gaps = 16/255 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ + P +D+R G+ V+ Q + +AKR+ E+GA + D+ + +G Sbjct: 1 MSFIVYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + + + +A I +P V GGI++ E A L G ++ + + A+ D R+ Sbjct: 61 KPANAAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQ 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G + I +G+D N T + + + + GA + Sbjct: 121 NDGDK-IAIGLDCR----------NGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHK 236 + +DG G ++E++ + +IASGG ++ L A V GA+ + Sbjct: 170 IARDGTMTGPNVEEIAALAMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYT 229 Query: 237 QIINIGELKAYLATQ 251 + E + + Sbjct: 230 DAFTLEEALQRMEGR 244 >UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Euryarchaeota RepID=HIS4_METBU Length = 246 Score = 230 bits (588), Expect = 3e-59, Method: Composition-based stats. Identities = 65/257 (25%), Positives = 127/257 (49%), Gaps = 17/257 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +IP +D++ G+ V+ VQ + D V +A + +GA L D+ + +G Sbjct: 1 MSFEVIPAVDMKGGKCVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIEG 60 Query: 59 RVVDKSWVSRVAEVI---DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + + ++ E I V GGI+S EDAA +L G DK+ +++ AL DP LI + Sbjct: 61 NRTNAPIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLLDIGIDKVILSTAALKDPELIKK 120 Query: 116 LADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIV 175 L+D FG + I V +D+ N E T+ ++ ++ + +++GAG I+ Sbjct: 121 LSDEFGSEHINVALDSK----------NGKISIEGWTKESEHTAVEMGSQFEEKGAGSIL 170 Query: 176 LNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 ++ +G+ NG + + +++ +P+IASGG T+E + ++ G + S + Sbjct: 171 FTNIDSEGLLNGVNPKPTEELVNAVTIPVIASGGVTTLEDIV-TLKNTGAAGVVVGSALY 229 Query: 236 KQIINIGELKAYLATQG 252 K+ + E ++ + Sbjct: 230 KKRFTLTEAINIISDKN 246 Score = 49.9 bits (118), Expect = 9e-05, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 50/136 (36%), Gaps = 5/136 (3%) Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 + + D + GK V G ++ + ++ + +GA + L ++ Sbjct: 1 MSFEVIPAVDMKGGK-CVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIE 59 Query: 185 RNGYDLEQLKKVREVC---HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 N + +KK+ E C + + GG + E D +D + ++ K I Sbjct: 60 GNRTNAPIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLL-DIGIDKVILSTAALKDPELI 118 Query: 242 GELKAYLATQGVEIRI 257 +L ++ + + + Sbjct: 119 KKLSDEFGSEHINVAL 134 >UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Cyanobacteria RepID=HIS4_PROMS Length = 255 Score = 230 bits (588), Expect = 3e-59, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 116/253 (45%), Gaps = 16/253 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ +G+ V+ + + + A+ + EGA + D+ A+ G Sbjct: 1 MDLIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++A+ ++IP + GGI+S E ++ S+G +K+ + + A+ + L+ L+++F Sbjct: 61 TNDKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + IV DA+ GK + + D V+E ++ +N Sbjct: 121 PGRIIVG-----IDAKDGKVSTRGWL------EQSNIFATDLVKEFSSFKIASFIVTDIN 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 DG G + E +K + E+ +P+IASGG G++ L F ++ + G + ++ Sbjct: 170 TDGTLEGTNEEFIKSILEITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENK 229 Query: 239 INIGELKAYLATQ 251 I E L+ + Sbjct: 230 FTINEANNVLSAE 242 >UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_DESAP Length = 262 Score = 230 bits (586), Expect = 4e-59, Method: Composition-based stats. Identities = 60/257 (23%), Positives = 114/257 (44%), Gaps = 16/257 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+R G+ V+ Q R D V +A+ + E+GA L D+ + G+ Sbjct: 1 MLIIPAVDLRGGRCVRLFQGRADQETVYSTDPVAVARTWEEQGARRLHVVDLDGAFTGKP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V + + ++IP V GGI++ E+ L G D++ + + AL +P + + + Sbjct: 61 QNSGVVLDIVKSVNIPVQVGGGIRNPENVKCYLEHGVDRVILGTAALTNPEFLDAVVAAY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IVVG+D + + + + L +++E+ +RG +V + Sbjct: 121 G-ERIVVGVDCR----------DGRVCVQGWEQTAATDVLPFLEELVRRGVRRVVFTDVK 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVFHKQI 238 +DG G +LE++ +V + +IASGG +E + VD + + Sbjct: 170 RDGTLEGPNLEEIARVAAHTELKVIASGGVSRLEDLRALKKLEHLGVDSVIIGKALYAGT 229 Query: 239 INIGELKAYLATQGVEI 255 I + E A + + Sbjct: 230 ITLAEALALERKEKDNV 246 >UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Chlorobiaceae RepID=HIS4_PROA2 Length = 261 Score = 230 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 57/246 (23%), Positives = 105/246 (42%), Gaps = 15/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D++DG+ V+ + + + + +A + ++ A L D+ A+ G + Sbjct: 1 MLIIPAIDIKDGKCVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGTM 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + +DIP V GGI+S ED + L G ++ I S A+ +P LI L F Sbjct: 61 VNFEKIREIVATLDIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELLATF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 IVVGID N + T + + + E++K G I+ ++ Sbjct: 121 SPSQIVVGIDAE----------NGIPKIKGWTESSSMQDYELALEMKKLGVKRIIYTDIS 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG+ G E ++ + + ASGG + + + VD + ++ Sbjct: 171 RDGMMQGVGYESTRRFAMKAGMRVTASGGVTSSDDLKKLQTLEQYGVDSVIVGKALYESN 230 Query: 239 INIGEL 244 +L Sbjct: 231 FPCQQL 236 Score = 59.1 bits (142), Expect = 2e-07, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 45/129 (34%), Gaps = 2/129 (1%) Query: 127 VGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRN 186 + I D + GK V GD + ++ D +K+ A + + ++ Sbjct: 1 MLIIPAIDIKDGK-CVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGT 59 Query: 187 GYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKA 246 + E+++++ +P+ GG + E V + S I EL A Sbjct: 60 MVNFEKIREIVATLDIPVQVGGGIRSFEDVERYLG-IGVSRVVIGSAAVTNPQLIAELLA 118 Query: 247 YLATQGVEI 255 + + + Sbjct: 119 TFSPSQIVV 127 >UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_FRAP2 Length = 241 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 48/247 (19%), Positives = 102/247 (41%), Gaps = 11/247 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+ +G+ V+ + + +AK Y + GA+ + D+ + G+ Sbjct: 1 MNIFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQT 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ E ++ V GG+K E K+L G D++ I S A+ D L + +++ Sbjct: 61 CQFETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IV+ +D + Y + + +Q G ++ ++ Sbjct: 121 GAEKIVLALDVFIKNGVP------YIATHGWQESSTTTLDEILQTYLGDGLEYVLCTDIS 174 Query: 181 QDGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G + E + + V +ASGG G++E E ++ + G + ++ Sbjct: 175 RDGMLQGPNFELYRIYSSIYPDVQFMASGGVGSLEDL-EILKEQNTYGVIIGKALYENKF 233 Query: 240 NIGELKA 246 + E Sbjct: 234 TLQEALE 240 >UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Persephonella marina EX-H1 RepID=HIS4_PERMH Length = 241 Score = 227 bits (578), Expect = 3e-58, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 110/248 (44%), Gaps = 16/248 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 L +IP +D++DG+ V+ + D V +AK++ E+GA L D+ + +G Sbjct: 3 LRSFVIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + V + + + IP GG++S E I+ G +++ I S A + R+ Sbjct: 63 KPKNIDIVKDIVKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVS 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 + + IV DA+ GK + + T++ LD+ + + Sbjct: 123 AYPGKVIVG-----IDAKDGKVAIKGWL------EKTEYTPLDFARMFDDLDIWGFLYTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHK 236 +N+DG G ++E K + + P+IASGG G++E + + V G + ++ Sbjct: 172 VNRDGAMVGPNIEGTKYLAQNLKHPVIASGGVGSVEDLKKLYDLKKYGVYGVVVGKALYE 231 Query: 237 QIINIGEL 244 I + +L Sbjct: 232 GKIKLEQL 239 >UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_LACLS Length = 246 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 46/255 (18%), Positives = 113/255 (44%), Gaps = 15/255 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+++G+ V+ + + + + +A+++ + GA L D+ + G+ Sbjct: 1 MEIIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQT 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILS-FGADKISINSPALADPTLITRLADR 119 + V ++ + ++ + GGI++L+ + L G +++ + + A P + L + Sbjct: 61 RNLEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVK 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 +G+ IVVG+D + T L ++++++K G +++ + Sbjct: 121 YGLSRIVVGVDIR----------EGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDI 170 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG G + E ++ + + +I SGG A D+D G + +++ I Sbjct: 171 SKDGTLTGPNFELYDEISKETSLDVIVSGGVKDSSDIQRA-ADSDFYGIIVGKAYYEGKI 229 Query: 240 NIGELKAYLATQGVE 254 N+ + + + Sbjct: 230 NLEKEFNHANKKNYP 244 >UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DY29_METI4 Length = 248 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 114/247 (46%), Gaps = 13/247 (5%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ++ +D+ GQVV+ Q + E D V A + +GAD L D+ + G Sbjct: 8 TMKMYAAIDLFKGQVVRLRQGKLEEMTVYGSDPVKTALFWQSQGADGLHIVDLEGAFSGT 67 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + ++A + IP GG++++E K L GA ++ I S + DP + L+++ Sbjct: 68 PRHLDLLEKIAYAVTIPIQFGGGLRTVEQVLKALEGGAQRVVIGSKLVTDPGFLQELSEK 127 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 G + IV +D N E + + + ++++ V+++GAG ++ + Sbjct: 128 IGPEKIVAALD----------TQNGEIQIEGWKKSSGYSLENFIKWVEQKGAGFLLYTNI 177 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG G D+ +KV E+ +P+ ASGG G + E + + GA+ ++ I Sbjct: 178 QTDGTLKGADVRGTQKVVEMSRLPVFASGGIGCTKDVEELLKLKGLYGAILGRSLYEGKI 237 Query: 240 NIGELKA 246 ++ E+K Sbjct: 238 SLSEIKK 244 >UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hisF n=76 Tax=Bacteria RepID=HIS6_MYCBP Length = 267 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 109/256 (42%), Positives = 146/256 (57%), Gaps = 2/256 (0%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LA R+IPCLDV DG+VVKGV F N GD V LA Y EGADEL F D+TASS GR Sbjct: 13 LAVRVIPCLDVDDGRVVKGVNFENLRDAGDPVELAAVYDAEGADELTFLDVTASSSGRAT 72 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R AE + IP V GG++++ D +L GADK+++N+ A+A L+ +A +FG Sbjct: 73 MLEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFG 132 Query: 122 VQCIVVGIDTWYDAETGKYHVNQY-TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 QCIV+ +D + + R T + + W G GEI+LN M+ Sbjct: 133 SQCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMD 192 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG + G+DL L+ VR VP+IASGGAG +EHF A A SVFH + + Sbjct: 193 ADGTKAGFDLALLRAVRAAVTVPVIASGGAGAVEHFAPAVAAGADAVLAA-SVFHFRELT 251 Query: 241 IGELKAYLATQGVEIR 256 IG++KA LA +G+ +R Sbjct: 252 IGQVKAALAAEGITVR 267 >UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Synechococcus sp. CC9311 RepID=Q0IDQ9_SYNS3 Length = 255 Score = 224 bits (572), Expect = 2e-57, Method: Composition-based stats. Identities = 94/256 (36%), Positives = 144/256 (56%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP LD++ G ++KGVQ +GD + AKRY+E GADEL+F D+ AS R Sbjct: 1 MRNLRIIPRLDIKSGTLIKGVQMEGWRKVGDPILAAKRYSEYGADELLFMDVVASLYERN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V +V + IP V GGI+ ++D +LS GADK+S+N+ AL P LI ++DR+ Sbjct: 61 TLHEIVEQVCSNVFIPVTVGGGIRKIKDVETLLSRGADKVSVNTGALLKPELINEISDRY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q V+ ++ E + ++ + E ++WV+E + RGAGEIVL ++ Sbjct: 121 GSQATVLTVECLKCGEKSWEAL-----TDNGRNRSGREVIEWVKEAENRGAGEIVLTSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 QDG G+D++ + V + ++P+IASGG G H +E + DV GA A H + ++ Sbjct: 176 QDGRGYGFDIDLVDIVSQAVNIPIIASGGFGKPSHIVELIKSTDVSGAAIAQALHWEKVS 235 Query: 241 IGELKAYLATQGVEIR 256 E++ L V +R Sbjct: 236 FSEIRDSLRDNNVFLR 251 >UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Aquificales RepID=HIS4_SULSY Length = 239 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 115/248 (46%), Gaps = 16/248 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDG 58 L + IIP +D++ G+VV+ + + + + +AK + + GA+ + D+ + +G Sbjct: 3 LKEFIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + + ++IP GG++S E +L G +++ I S A +P ++ + Sbjct: 63 LPKNIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIVE 122 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 F + IV DA+ GK + + T T+ L++ ++ + Sbjct: 123 SFPNKVIVG-----IDAKDGKVAIKGW------TEKTEVSPLEFAKKYDDLDIFGFLFTD 171 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHK 236 +++DG G ++E ++ + P+IASGG G++E ++ + + G + ++ Sbjct: 172 VSRDGSMIGANVEATVELAKNLKHPVIASGGVGSLEDVIKLYEKREFGIFGVVVGKAIYE 231 Query: 237 QIINIGEL 244 I++ E+ Sbjct: 232 GKIDLKEI 239 Score = 50.6 bits (120), Expect = 6e-05, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 48/116 (41%), Gaps = 2/116 (1%) Query: 131 TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDL 190 D + GK V Y G+ + +V +D + + GA I + ++ ++ Sbjct: 9 PAIDIKGGKV-VRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEGLPKNI 67 Query: 191 EQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKA 246 + L+ + ++P+ GG + E ++A D V+ + S+ ++ ++ Sbjct: 68 KILESIVRSVNIPIEFGGGLRSFE-AVKAVLDLGVERVVIGSLAYQNPEEFYKIVE 122 >UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=6 Tax=Euryarchaeota RepID=D2RTG3_9EURY Length = 244 Score = 223 bits (570), Expect = 3e-57, Method: Composition-based stats. Identities = 63/249 (25%), Positives = 124/249 (49%), Gaps = 14/249 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRN--HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++IP +D++DG+VV+ VQ + GD V A+R+ +EGA+ L D+ + +G+ Sbjct: 7 FQVIPAVDMQDGEVVQLVQGERGTEKTYGDPVDAARRWLDEGAEALHLVDLDGAFEGQRA 66 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + V E +D+P + GGI++ +DA +L G D++ + + A+ +P ++ +++R Sbjct: 67 NGDAIDEVLETVDVPTQLGGGIRTADDAVDLLERGVDRVILGTAAVENPDIVAEISERHP 126 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 +V DA+ G+ V + T +D + + GA I+ ++ Sbjct: 127 DSVVV-----SLDAKDGEVVVEGW------TEGAGISPVDAAERYAELGAAAILFTNVDV 175 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 +G G E ++++ E VP+IASGG T+E A DA + S ++ + Sbjct: 176 EGKLEGVAAEPVRELVEATDVPVIASGGVATLEDV-RALEDAGAAAVVVGSALYEGKFTL 234 Query: 242 GELKAYLAT 250 E ++ + + Sbjct: 235 AEAQSAIDS 243 >UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=91 Tax=Bacteria RepID=HIS4_SYNJB Length = 261 Score = 223 bits (570), Expect = 3e-57, Method: Composition-based stats. Identities = 66/246 (26%), Positives = 113/246 (45%), Gaps = 14/246 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFRN---HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IP +D+ G+ V+ Q ++ D + A+ +A +GA L D+ + G V Sbjct: 9 EVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPV 68 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + R+ + IP V GGI+SLE A ++L G D++ + + A+ DP + + F Sbjct: 69 NLPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFP 128 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + + VGID T + VQ VQ +GA I+ +++ Sbjct: 129 GR-VWVGIDARQ----------GQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISR 177 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G +LEQL+++ V VP+IASGG G++ L + GA+ + I++ Sbjct: 178 DGTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISL 237 Query: 242 GELKAY 247 E Sbjct: 238 QEALRA 243 >UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=31 Tax=cellular organisms RepID=HIS4_CHRSD Length = 249 Score = 223 bits (570), Expect = 3e-57, Method: Composition-based stats. Identities = 58/254 (22%), Positives = 110/254 (43%), Gaps = 17/254 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++DGQ V+ Q + D V +A R+ E GA L D+ + +G+ Sbjct: 1 MLVIPAIDLKDGQCVRLKQGRMDDSTTYGDDPVAMAARWVETGARRLHLVDLNGAFEGKP 60 Query: 61 VDKSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V+ V+ +A D+P + GGI++ E L G + I + A+ +P + + R Sbjct: 61 VNAEAVTAIARAYPDLPIQIGGGIRTAETIEAYLEAGVSYVIIGTQAVKEPAFVGEMCRR 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 F ++VG+D + Y + V+ + +D + G IV + Sbjct: 121 FPGH-VIVGLDAR----------DGYVATDGWAEVSTLKAVDLAKRFADDGVSSIVYTDI 169 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR--DADVDGALAASVFHKQ 237 +DG+ G ++ ++ +P+IASGG + DA + GA+ ++ Sbjct: 170 ARDGMMQGVNIAATAELAREGGLPVIASGGVTHLGDIEALLEVADAGILGAITGRAIYEG 229 Query: 238 IINIGELKAYLATQ 251 +++ E + Q Sbjct: 230 KLDVAEAQRLCDAQ 243 >UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase subunit n=3 Tax=Bacteria RepID=Q2LTH2_SYNAS Length = 254 Score = 223 bits (570), Expect = 3e-57, Method: Composition-based stats. Identities = 99/257 (38%), Positives = 145/257 (56%), Gaps = 3/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M +I+PCLD+++G+VVKG+ F + GD V A Y EGADEL DI A+ + R Sbjct: 1 MKPIKIMPCLDMKEGRVVKGIHFVELKDAGDPVENAAFYQAEGADELAMLDIAATLENRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 WV++V+ V+ IP V GGI +LED +L GA KIS+NS A+ +P+L++ A +F Sbjct: 61 TRLEWVNKVSAVLTIPLTVGGGISTLEDIELVLQAGAAKISMNSAAVKNPSLVSEAAKKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I V ID + T + + W + Q+ GAG I+ M+ Sbjct: 121 GSEKITVAIDARR---NSQMPSGFELVVSGGTLPVARDAVAWARTCQELGAGVILPTSMD 177 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG R GYD+E K + + +P++ASGGAG +E F EA + LAASVFH + ++ Sbjct: 178 GDGTRAGYDIEYTKAIADAVDLPVVASGGAGKLEDFYEAVQKGGASILLAASVFHYRTLS 237 Query: 241 IGELKAYLATQGVEIRI 257 I +K YLA +G+ + I Sbjct: 238 IRAVKQYLADRGLPVII 254 >UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Firmicutes RepID=HIS4_CLOD6 Length = 240 Score = 223 bits (569), Expect = 4e-57, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 115/248 (46%), Gaps = 15/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D++D + V+ Q + + + +A ++ EGA+ + D+ + Sbjct: 1 MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + +A IDIP V GG++ E +++ G ++ + S A+ + L+ L + + Sbjct: 61 VNTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + +V DA+ GK V + V+ ++L ++++K G IV ++ Sbjct: 121 KEKIVV-----SIDAKDGKVAVRGW------EVVSNVDSLTLCKQLEKIGVQTIVYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G + + +++ + + +IASGG ++E + ++ GA+ + + I+ Sbjct: 170 KDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKR-LKAMNLYGAIIGKALYDKKID 228 Query: 241 IGELKAYL 248 E + Sbjct: 229 FKEAQQLC 236 Score = 62.6 bits (151), Expect = 1e-08, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 45/114 (39%), Gaps = 2/114 (1%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++I+ +D +DG+V V+ D + L K+ + G +V+ DI+ + + Sbjct: 121 KEKIVVSIDAKDGKV--AVRGWEVVSNVDSLTLCKQLEKIGVQTIVYTDISKDGMLQGPN 178 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 R+A+ + +GG+ S+ED ++ + I Sbjct: 179 FDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEA 232 Score = 49.1 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 15/94 (15%), Positives = 36/94 (38%), Gaps = 1/94 (1%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL 217 L+ + + GA I + +N G + + ++ + +P+ GG E Sbjct: 31 NPLEVAYKWKNEGAEYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVGGGVRDKEKV- 89 Query: 218 EAFRDADVDGALAASVFHKQIINIGELKAYLATQ 251 ++ +A V + S+ + + + EL + Sbjct: 90 KSLINAGVTRVILGSIAIENLNLVEELVNEYKEK 123 >UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW6_HODCD Length = 264 Score = 223 bits (569), Expect = 5e-57, Method: Composition-based stats. Identities = 102/255 (40%), Positives = 150/255 (58%), Gaps = 6/255 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 LA RIIPC+DV++G VVKG +F +G+ +A Y+ GADEL F D++ASS R + Sbjct: 5 LALRIIPCMDVKEGHVVKGSKFCGLVRVGEATLVANSYSVSGADELCFLDVSASSANRSI 64 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + +S+VAE IP V GG++ ++D +L GADK+SINS + P I R D+FG Sbjct: 65 LYATISQVAESCLIPLTVGGGVRRVKDVGDLLRAGADKVSINSAGVLSPEFIARCVDKFG 124 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QC+VV ID A G + V + R T + L++ + + GAGEI+L +++ Sbjct: 125 SQCVVVSIDCK--ASDGAWEVCTH----GGARPTGVDALEYACQAAQFGAGEILLTSVDR 178 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DGV+ GYDL LK V + VP+IASGG G + HF A + L AS+ H+ + + Sbjct: 179 DGVKAGYDLALLKAVSSLVSVPVIASGGGGELSHFALALIEGGASAVLTASLLHRNELTV 238 Query: 242 GELKAYLATQGVEIR 256 +LK +L + G+ +R Sbjct: 239 SQLKFFLGSCGIVVR 253 Score = 45.2 bits (106), Expect = 0.002, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 43/106 (40%), Gaps = 5/106 (4%) Query: 31 DIVPLAKRYAEEGADELVF--YDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED 88 D + A + A+ GA E++ D G D + + V+ ++ +P +GG L Sbjct: 155 DALEYACQAAQFGAGEILLTSVDRDGVKAG--YDLALLKAVSSLVSVPVIASGGGGELSH 212 Query: 89 -AAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWY 133 A ++ GA + S + +++L G IVV D Sbjct: 213 FALALIEGGASAVLTASLLHRNELTVSQLKFFLGSCGIVVRDDYVR 258 >UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hisF n=14 Tax=Bacteria RepID=HIS6_BEUC1 Length = 256 Score = 223 bits (568), Expect = 6e-57, Method: Composition-based stats. Identities = 103/254 (40%), Positives = 148/254 (58%), Gaps = 1/254 (0%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 A R++PCLDV G+VVKGV F + GD V LA+RY +GADE+ F D++AS+ GR Sbjct: 4 ALRVVPCLDVDGGRVVKGVNFLDLRDAGDPVELARRYDADGADEITFLDVSASTQGRATT 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 VS AE + +P V GG++++ D +L GADK+ +N+ A+A P L+T +A +G Sbjct: 64 LEMVSATAEQVFVPLTVGGGVRAVADVEALLRAGADKVGVNTAAIARPELLTEIAQHYGN 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q +V+ +D + T + ++W E RGAGE++LN ++ D Sbjct: 124 QVLVLSVDARRCPDGVVTDSGFEVTTHGGRTGTGIDAVEWAAEATSRGAGEVLLNSIDAD 183 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G+D+E ++ VR V PL+ASGGAGT+E F+ A R D LAASVFH + I Sbjct: 184 GTTAGFDVEMIEAVRAVVDTPLVASGGAGTVEDFVAAARAG-ADAVLAASVFHYGTLTIS 242 Query: 243 ELKAYLATQGVEIR 256 E+KA L G E+R Sbjct: 243 EVKAALRDAGFEVR 256 >UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrio RepID=HIS4_DESVH Length = 249 Score = 222 bits (567), Expect = 7e-57, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 110/254 (43%), Gaps = 17/254 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + P +D+ +G V+ + D V A+ + E+G L D+ + G+ Sbjct: 1 MIVFPAIDLMNGVCVRLRRGRADDETVFSSDPVATARHWQEQGGRWLHVVDLDGAFSGQP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + + +DIP + GGI+ A L G +++ I + AL +P L F Sbjct: 61 VNAPLIRSICDALDIPVQLGGGIRDAATAKAYLEAGVERLIIGTIALEEPDAYAALCAEF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + V DAE GK + D + + + + + G I+ ++ Sbjct: 121 PGRIGV-----SLDAEGGKLKTKGWVAD------SGLTVDEVLPRLLEAGTAFIIYTDID 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF---RDADVDGALAASVFHKQ 237 +DG++ G +L L+ + + VP+IA+GG T+E + R ++ GA++ ++ Sbjct: 170 RDGMQTGVNLPALEHLAKASTVPVIAAGGVATLEDVKALYPLSRTTNLQGAVSGRAIYEG 229 Query: 238 IINIGELKAYLATQ 251 +++ ++ Q Sbjct: 230 TLDLRTAMDWIRQQ 243 >UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Bacilli RepID=HIS4_STRSV Length = 242 Score = 222 bits (567), Expect = 7e-57, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 113/250 (45%), Gaps = 15/250 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +I+P +D++DGQ V+ + + D++ A+ + E G + D+ + +G Sbjct: 1 MSMKILPAIDIKDGQAVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALEG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R ++ ++++ + V GGI+SLE L+ G D++ I S A+ +P + + Sbjct: 61 RAANRDLIAQIKAETGLAIQVGGGIRSLEQIEDYLAVGIDRVIIGSMAVKNPEFVEAALE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 RFG IV+GID E + + + ++K G V Sbjct: 121 RFGSGKIVIGIDAK----------EGLVATEGWLETSNQDYISLALAMEKIGVRLFVYTD 170 Query: 179 MNQDGVRNGYDLEQLKKVREVCHV-PLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +++DG G +++ +K+ +IASGG + + E + + GA+ ++ Sbjct: 171 VDRDGTLTGPNIQHYQKLLASLKHAQVIASGGIQSADDLEEM-KKLGLAGAIVGKAYYSG 229 Query: 238 IINIGELKAY 247 I++ ++K Sbjct: 230 RISLEQIKEA 239 Score = 50.2 bits (119), Expect = 7e-05, Method: Composition-based stats. Identities = 18/131 (13%), Positives = 48/131 (36%), Gaps = 2/131 (1%) Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 + + I D + G+ V + GD S+ V + L+ + ++ G I + + Sbjct: 1 MSMKILPAIDIKDGQ-AVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALE 59 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 + + + +++ + + GG ++E + +D + S+ K + Sbjct: 60 GRAANRDLIAQIKAETGLAIQVGGGIRSLEQIEDYL-AVGIDRVIIGSMAVKNPEFVEAA 118 Query: 245 KAYLATQGVEI 255 + + I Sbjct: 119 LERFGSGKIVI 129 >UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_DESHD Length = 250 Score = 222 bits (567), Expect = 8e-57, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 123/257 (47%), Gaps = 18/257 (7%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 + R+ P +D+++G+ V+ +Q R V +A+++ E+GAD L D+ + G Sbjct: 1 MRMRLFPAIDLKEGKAVRLLQGRMEDATVYGEQPVEVARKFKEQGADSLHVVDLDGAFAG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + V+ + + ++ + + V GGI++LE ++L G +++ + + A+ +P L+ + Sbjct: 61 KPVNDAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQ 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 RF + +V+GID + + T+ + LD ++K G +V Sbjct: 121 RF-EEAVVIGIDAK----------DGLVAVQGWAEKTEIKALDLALRMKKVGVKHLVFTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD----VDGALAASVF 234 +++DG+ G +++ ++ + + ++ASGG +E +A+ ++GA+ Sbjct: 170 ISRDGMLQGPNIQSTVELARLSGLQVVASGGVSRLEDLRLLQEEANRGVSLEGAIVGKAL 229 Query: 235 HKQIINIGELKAYLATQ 251 + ++ E + + Sbjct: 230 YAGAFSLAEALRVVGQR 246 >UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF74_THET1 Length = 243 Score = 222 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 104/247 (42%), Gaps = 15/247 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ +GQ+V+ Q D V +A+++ GA L D+ + G Sbjct: 1 MIVIPAIDILEGQLVRLTQGDYSRKKVYSYDPVVVARKWKAIGAQWLHVVDLDGARQGHP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + V V GG+++LED I+ GA +I + + A+ DP + + ++ Sbjct: 61 VNVDVIKSVIMEFGPQVQVGGGLRTLEDIQSIVELGASRIVLGTSAVKDPEFLREVCAKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 +V +DT N + T+ + + L+ + V+ G G I+ + Sbjct: 121 P-DMVVAALDTR----------NGVVAIDGWTKSSGLDVLEVAKLVEDAGVGYILFTAIE 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG G D+ ++++ VP+IASGG E E A V + ++ + Sbjct: 170 TDGTMTGPDIAAVQRLMSHVSVPVIASGGISEPEDLEE-LSKAGVYAVIVGKALYEGRLP 228 Query: 241 IGELKAY 247 + Y Sbjct: 229 EEVITTY 235 >UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Bacillales RepID=HIS4_BACLD Length = 245 Score = 221 bits (564), Expect = 2e-56, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 111/256 (43%), Gaps = 16/256 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 M + P +D+R+G+ V+ +Q + + +A R+AEEGA + D+ + + Sbjct: 1 MSEFTVYPAIDIRNGKCVRLIQGDYEKETIYGHSPLEMASRFAEEGASWIHLVDLDGARE 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ V+ V +A+ +D+ V GGI++ +D LS G +++ + S A+++ + ++ Sbjct: 61 GKKVNGGHVISIADKLDVKVQVGGGIRTEKDVYDYLSQGVERVILGSSAVSNTEFVKKML 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +G I +G+D + + E + + +E+ GA + Sbjct: 121 KAYGGH-IAIGLDAR----------DGFVSTEGWLETSSVRAEELGRELANEGAEVFIFT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFH 235 + DG+ +G ++ ++ +IASGG ++ A V GA+ + Sbjct: 170 DIATDGMLSGPNINSTVELARATGKQVIASGGVSSLADLEALASRASEGVSGAIVGKALY 229 Query: 236 KQIINIGELKAYLATQ 251 + E +A + Sbjct: 230 TNQFTVAEALERVAAK 245 >UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=23 Tax=Bacteria RepID=HIS4_THEEB Length = 257 Score = 221 bits (563), Expect = 2e-56, Method: Composition-based stats. Identities = 55/252 (21%), Positives = 109/252 (43%), Gaps = 16/252 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ DG+ V+ VQ ++ D + +A + GA L D+ A+ G Sbjct: 1 MDVIPAIDLLDGKCVRLVQGNYDKVNVFHDDPLKVALYWQRLGAPRLHLVDLDAAKTGEP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ ++IP V GG++S + A + G ++ + + AL +P L+ LA + Sbjct: 61 RNYDLIGKIVASLEIPVQVGGGLRSRQAVADLFLQGVNRAILGTVALENPKLVASLAAEY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I VG+D + Y ++ D Q + G V + Sbjct: 121 PGR-IWVGLDAR----------DGYVATRGWLETSKILATDLAQNMAAMGVAGFVYTDIQ 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHKQI 238 +DG G ++ L+++ V + P+IASGG ++ L F + GA+ + + Sbjct: 170 RDGTLQGPNIPALRQLLAVTNRPVIASGGVSSLNDILSLFALTPHGLVGAIVGKALYTKA 229 Query: 239 INIGELKAYLAT 250 +++ E + Sbjct: 230 MDLREAVRAVGQ 241 >UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=root RepID=HIS4_PELUB Length = 239 Score = 221 bits (563), Expect = 2e-56, Method: Composition-based stats. Identities = 53/250 (21%), Positives = 109/250 (43%), Gaps = 14/250 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D++D + V+ ++ E V A +Y + G L D+ + G Sbjct: 1 MKIFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGET 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + D+ V GG++S++ K ++ G +K+ + S A+ + + +F Sbjct: 61 VNLDIIKEIVHKFDLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I +G+D + Y + TLD+++EV GA ++ +N Sbjct: 121 PNK-IALGLDAK----------DGYLSVSGWKENSNQLTLDFLKEVNDYGASRLIYTDIN 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + + E+ V V + P+I SGG +++ +A +++G + + I Sbjct: 170 RDGTKESPNFEETTNVANVSNCPVIISGGVSSIDDIKKAKGLKNIEGIIVGKAIYDGDIK 229 Query: 241 IGELKAYLAT 250 + EL L Sbjct: 230 LEELVKELDA 239 >UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Prochlorococcus marinus RepID=A2C5V2_PROM3 Length = 500 Score = 221 bits (563), Expect = 2e-56, Method: Composition-based stats. Identities = 88/255 (34%), Positives = 140/255 (54%), Gaps = 5/255 (1%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 L+KRII LDV+ +++KGV+F +IGD + +A++YA+ G DEL++ D AS GR Sbjct: 15 LSKRIIARLDVKGNKIIKGVRFEGLRVIGDPLDMARKYAKAGIDELLYIDAVASLYGRNS 74 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + IP GGI++LEDA +LS GADKI+IN+ AL P LI+ L++ G Sbjct: 75 LIEVLKSTSSEVFIPITAGGGIRNLEDAKLLLSNGADKIAINTAALECPQLISELSNTLG 134 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 QC+VV I + + + ES + + + W++ VQ GAGEI+L ++Q Sbjct: 135 SQCVVVSIQARASSSSSWDAMK-----ESGREKSGIDVIKWIENVQLLGAGEILLTSVDQ 189 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG D ++KV + +PLI SGG +A ++ + + H Q N+ Sbjct: 190 DGTCIKPDEILIQKVLPILKLPLIVSGGFSDPNQVYQALTNSRISAVAIGAALHYQKTNV 249 Query: 242 GELKAYLATQGVEIR 256 ++K+ L+ + IR Sbjct: 250 SDIKSMLSFNNIAIR 264 >UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=209 Tax=Bacteria RepID=HIS4_HERAR Length = 265 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 53/262 (20%), Positives = 114/262 (43%), Gaps = 26/262 (9%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++DG V+ Q + D +A+ + E+GA L D+ + G+ Sbjct: 1 MLLIPAIDLKDGHCVRLKQGDMDQATVFSEDPADMARHWLEQGARRLHLVDLNGAFAGKP 60 Query: 61 VDKSWVSRVAEVI----------DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP 110 ++ V + + + +IP + GGI+ L+ + L G I I + A+ +P Sbjct: 61 KNEPAVKAILQAVREYAEKNGIEEIPVQLGGGIRDLDTIERYLDDGLSYIIIGTAAVKNP 120 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 + F Q IV DA+ GK + + ++++ E +D ++ + G Sbjct: 121 GFLHDACSAFPGQIIVG-----LDAKDGKVATDGW------SKLSGHEVIDLAKKFEDYG 169 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE--AFRDADVDGA 228 I+ + +DG+ G ++E K+ + +P+IASGG ++ A ++ ++G Sbjct: 170 CESIIYTDIGRDGMMGGVNIEATVKLAQSMTIPVIASGGVHNIKDVEALCAVQEEGIEGV 229 Query: 229 LAASVFHKQIINIGELKAYLAT 250 + ++ +++ + Sbjct: 230 ICGRSIYEGTLDLRSAQDRADE 251 >UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MJ01_RHOM4 Length = 266 Score = 220 bits (560), Expect = 4e-56, Method: Composition-based stats. Identities = 51/240 (21%), Positives = 103/240 (42%), Gaps = 17/240 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+R G+ V+ Q D V +A + + A L D+ A+ G+ + Sbjct: 4 VIPAIDIRGGRCVRLYQGSYERETVYFDDPVKMACLWRVQNARVLHVVDLDAAR-GQGHN 62 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + + +DIP V GG+++LED +L G ++ + + A+ +P L++ R+G Sbjct: 63 REVIGAICRTVDIPIQVGGGVRTLEDIEALLQVGVYRVVLGTAAVREPELVSEAIARYGC 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +VVGID + + T T + ++ ++++RG V +++D Sbjct: 123 SRVVVGIDAR----------DGEVRVQGWTEGTGVDAVELALDMERRGVRRFVYTDISRD 172 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQII 239 G G ++E + + + + ASGG + VD + ++ Sbjct: 173 GTLEGPNVEMYRTLGLHLKKARITASGGVSGYRDLMRLQELEPYRVDSVIIGRALYENRF 232 >UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Chlorobiaceae RepID=HIS4_CHLT3 Length = 262 Score = 219 bits (559), Expect = 7e-56, Method: Composition-based stats. Identities = 55/246 (22%), Positives = 112/246 (45%), Gaps = 15/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D++ G+ V+ + + + + +A + ++ A + D+ A+ G+ Sbjct: 1 MLIIPAIDIKGGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALTGKP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ + +DIP + GGI++ EDAA+ L G ++ I S A+ +P+L+++L +++ Sbjct: 61 ENFDKIKQIVDTLDIPIEIGGGIRTAEDAARYLDIGVYRVVIGSAAVKNPSLVSQLIEKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IVVGID + T +Q + + E++ RG I+ + Sbjct: 121 GPRKIVVGIDAE----------DGIAKISGWTESSQKKDYELALEMKDRGVERIIYTDIT 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG G E K E + + ASGG + + VD + +++ Sbjct: 171 RDGTLEGVGYETTKAFAEKAQMRITASGGVFGKQDLSKLCKLEHLGVDSVIIGKALYEER 230 Query: 239 INIGEL 244 +L Sbjct: 231 FPCQKL 236 Score = 49.5 bits (117), Expect = 1e-04, Method: Composition-based stats. Identities = 20/118 (16%), Positives = 43/118 (36%), Gaps = 1/118 (0%) Query: 138 GKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVR 197 G V GD + ++ E D +K+ A I + ++ + +++K++ Sbjct: 11 GGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALTGKPENFDKIKQIV 70 Query: 198 EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEI 255 + +P+ GG T E D V + S K + +L + + + Sbjct: 71 DTLDIPIEIGGGIRTAEDAARYL-DIGVYRVVIGSAAVKNPSLVSQLIEKYGPRKIVV 127 >UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Salinibacter ruber DSM 13855 RepID=HIS4_SALRD Length = 258 Score = 219 bits (558), Expect = 7e-56, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 113/240 (47%), Gaps = 16/240 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+RDG+ V+ Q D V +AK + + A L D+ A+ + Sbjct: 4 VIPAIDIRDGRCVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEHN 63 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + +DIP + GGI+S++ L G ++ + + A+ +P + R ++F Sbjct: 64 RDVIGKMCDALDIPIQLGGGIRSMDQIEAALDRGVYRVILGTAAVRNPDFVERAVEQFSA 123 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV ID + + T + + + + +++++RG +V +++D Sbjct: 124 RRVVVSIDAR----------DGEVRVQGWTEGSGLDAVAFAKDMEQRGVRRLVYTDISRD 173 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQII 239 G +G +++ + + R++ H + ASGG G + L+ + VD + + ++ Sbjct: 174 GTMDGPNIQAYRTLGRQLAHAKVTASGGVGEHDDLLDIQTLQPYGVDSVIVGTALYENRF 233 Score = 49.5 bits (117), Expect = 1e-04, Method: Composition-based stats. Identities = 16/127 (12%), Positives = 44/127 (34%), Gaps = 2/127 (1%) Query: 131 TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDL 190 D G+ V + GD V + + + + + A + + ++ ++ Sbjct: 6 PAIDIRDGR-CVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEHNR 64 Query: 191 EQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLAT 250 + + K+ + +P+ GG +M+ A V + + + + + Sbjct: 65 DVIGKMCDALDIPIQLGGGIRSMDQIEAALDR-GVYRVILGTAAVRNPDFVERAVEQFSA 123 Query: 251 QGVEIRI 257 + V + I Sbjct: 124 RRVVVSI 130 >UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CALS8 Length = 237 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 55/246 (22%), Positives = 100/246 (40%), Gaps = 14/246 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ DG+ V+ Q D V AK + +EGA L D+ + G Sbjct: 1 MIVIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + R+ E + GGI+ + L G D I + S +P + + RF Sbjct: 61 VNFEVIKRIKESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + + +D Y T+ + + ++K G +++ + Sbjct: 121 GNERFIASLDFE----------EGYVKLSGWQEATRISVEEGILHIKKLGFQKLIYTDIK 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ G++ E K +R + LI+SGG +M L+ +D VDG + + + Sbjct: 171 TDGMLKGHNFEAAKYIRSLFDGFLISSGGISSMNDVLK-LKDIGVDGVIIGKALYTGHVK 229 Query: 241 IGELKA 246 + E+ Sbjct: 230 LNEIIN 235 Score = 47.2 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 18/110 (16%), Positives = 43/110 (39%), Gaps = 1/110 (0%) Query: 142 VNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCH 201 V GD SR + + + + +K GA + + ++ + + E +K+++E Sbjct: 15 VRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPVNFEVIKRIKESTS 74 Query: 202 VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQ 251 + + GG + + A +D + SV K + ++ + Sbjct: 75 LSVECGGGIRDKKTINDYL-LAGIDYIILGSVIFKNPEFVEDVLKRFGNE 123 >UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CARHZ Length = 243 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 51/253 (20%), Positives = 103/253 (40%), Gaps = 16/253 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ +VV+ Q V LA +Y E GA + D+ + G Sbjct: 1 MILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGES 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ + + + IP V GGI+ +E +++ G ++ + + A+ +P L+ + Sbjct: 61 ENFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEML-TL 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + VGID N + + + + LD +V++ G I+ + Sbjct: 120 DRDKVAVGIDAK----------NGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIA 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVFHKQI 238 +DG G + + K+ + +IASGG +E + + G +A + Sbjct: 170 RDGSLTGPNFNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGK 229 Query: 239 INIGELKAYLATQ 251 I++ E L + Sbjct: 230 IDLKEGIRILEGE 242 >UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9Y4_9FIRM Length = 245 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 59/255 (23%), Positives = 108/255 (42%), Gaps = 16/255 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQF---RNHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 M A + P +D+R G V+ + + D +A+R+AE GA + D+ + Sbjct: 1 MEAMNLYPAIDLRGGMCVRLEKGNFSKETVYSKDPGAMARRFAEAGARTIHVVDLDGALA 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G+ + S + + I V GGI++ E +LS G ++ + S A+ DP L+ R Sbjct: 61 GKSENLSAIKAILREGGISIEVGGGIRTYEQIEGLLSLGVSQVILGSAAIYDPQLVERAN 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 F + IVVGID N Y + + + + V G I+ Sbjct: 121 RDFPYK-IVVGIDAK----------NGYAAADGWEKDSNLTAEALARRVAAAGTERIIFT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVFH 235 +++DG+ NG ++E + + C VP+ ASGG ++E +A ++G + + Sbjct: 170 DISRDGMMNGSNIEATAALYQACGVPITASGGVSSLEDIRRLKARETDGIEGCIIGKALY 229 Query: 236 KQIINIGELKAYLAT 250 ++ + Sbjct: 230 AGAFSLSDALKIAGE 244 >UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B9F8_THEAS Length = 253 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 90/256 (35%), Positives = 154/256 (60%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ KRIIP ++ ++VKG FR+H +GD V A +GA+E+V D+ A+ +GR+ Sbjct: 1 MMPKRIIPQFLLKGSRLVKGTSFRDHVDVGDPVSQAMIQDAQGAEEIVLVDVDATREGRL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 VD S +SR+ E +P V GG+ +++DA+++ GADK+ +N+ A+ +P++I LA+RF Sbjct: 61 VDTSLISRMVERCRLPIAVGGGVGNVDDASRLFVAGADKVIVNTAAVLNPSMIRPLAERF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV +D +++ G V S + + ++ ++ GAGE ++ ++ Sbjct: 121 GAQSVVVSLDLKRNSKRGWVPV-----VRSGEEEVDLDFVYLLEALEANGAGEFIVTSVD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G +G+DL+ LK VREV VPLIASGGAG H +E F D++G + + + Sbjct: 176 REGTLSGFDLDMLKVVREVVKVPLIASGGAGNYLHLVELFLSIDLEGVGIGKMLALRDYD 235 Query: 241 IGELKAYLATQGVEIR 256 + +KA+L +G+ +R Sbjct: 236 VVRIKAFLKGRGIPVR 251 >UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winogradskyi Nb-255 RepID=Q3SPZ7_NITWN Length = 258 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 86/257 (33%), Positives = 139/257 (54%), Gaps = 7/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVK-GVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ML KR+IP +RDG++VK F N I G+ V AK Y + G DEL+ DI S+ R Sbjct: 1 MLKKRLIPKFLLRDGRLVKYTCFFDNERIAGNPVTTAKVYNDYGVDELIVLDIVPSAASR 60 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + + R++E I +PF V GG+K+ ED +L GADK+SINS A+ P + A Sbjct: 61 ARVEDIIGRMSEEIFMPFTVGGGVKTAEDVNALLRAGADKVSINSEAVRRPEFVREAART 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG QCI V ID + + + ++W + GEI+++ + Sbjct: 121 FGDQCITVSIDYKRIG-----SHHASVYIDGGREHVALDPVEWALRCEDLHCGEILMSSI 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++DG GYDLE + + + VP+I SGG G+++H ++A +A +S+F Sbjct: 176 DRDGTMQGYDLEMINTLTKRLGVPMIVSGGCGSLQHAIDAL-EAGASAVAISSMFLFTDH 234 Query: 240 NIGELKAYLATQGVEIR 256 + +L+++LA++G+++R Sbjct: 235 SPIKLRSHLASRGLDVR 251 >UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Thaumarchaeota RepID=HIS4_NITMS Length = 236 Score = 217 bits (553), Expect = 3e-55, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 120/249 (48%), Gaps = 16/249 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IIP +D+ DGQVV+ + D V +AK++ + GAD L D+ A+ G Sbjct: 1 MKIIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDLDATI-GTG 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++++ + IP VAGG+++ E + +SF ++++ I + A D ++ R+A ++ Sbjct: 60 SNLDLIEKISKELSIPVEVAGGLRNEEIIDRAISF-SNRVVIGTMAFKDKEMLQRIAKKY 118 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 IV+ +D H++ + T+ LD + E G E +L ++ Sbjct: 119 DFSKIVISVD----------HIDGFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVS 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G DLE L+K V + +IASGG ++ + R + + ++ I+ Sbjct: 169 KDGTLEGPDLEYLEKACAVQNANVIASGGISNIDDVSDVQRK-NAFAVILGKALYENKIS 227 Query: 241 IGELKAYLA 249 I E K + Sbjct: 228 IEEAKQLVN 236 >UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E201_GEOLS Length = 282 Score = 217 bits (553), Expect = 4e-55, Method: Composition-based stats. Identities = 94/286 (32%), Positives = 141/286 (49%), Gaps = 33/286 (11%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP LD++ +VKG+ ++GD + A Y E GADEL++ DI AS R Sbjct: 1 MKPVRIIPRLDIKGPNLVKGIHLEGLRVLGDPIAFAHYYYENGADELIYSDIVASLYQRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + IP +AGG+++L D K L GADK+ IN+ A+ +P I + F Sbjct: 61 SILDLVTETSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVRVF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IVV ++ + + E+ + + E + WVQ V++ GAGEI+L +N Sbjct: 121 GSSTIVVAVEVVRNDDNSLIAY-----TENGRQSSGIEAVSWVQRVEELGAGEILLTSIN 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK---- 236 +G +GYD++ + +V +P+IA GGAG EH E F +DV A AS+FH Sbjct: 176 AEGTGDGYDMDLINRVVSAVSIPVIAHGGAGKPEHVREVFATSDVRAAAVASMFHYYAKK 235 Query: 237 ------------------------QIINIGELKAYLATQGVEIRIC 258 I+I ELK YL+ G+ R+ Sbjct: 236 LSADMNPVEGNLDFLRSGKSFSRVSEISIVELKQYLSKHGIVCRLV 281 >UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase subunit HisF n=1 Tax=Campylobacterales bacterium GD 1 RepID=B6BGE0_9PROT Length = 254 Score = 217 bits (552), Expect = 4e-55, Method: Composition-based stats. Identities = 84/257 (32%), Positives = 144/257 (56%), Gaps = 5/257 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M R+I +D+++ +KG+ +G+ +A RY E+G DE+V D AS R Sbjct: 1 MKKIRVIARIDIKNEHTIKGIHLEGLRKVGNPNEMALRYYEDGIDEIVLMDAVASLYDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 K + + E I IP V GG+++L+D + L+ GADK++IN+ A+ +P+ IT + +F Sbjct: 61 SLKDVIVKACEDIFIPITVGGGLRNLQDIQEALNSGADKVAINTQAIREPSFITTASKQF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI+ I + E+ T + L W +EVQ+ GAGEI+L ++ Sbjct: 121 GSQCIISSIVAKKIDDGKWEAY-----IENGREPTGVDVLAWAKEVQELGAGEIMLTSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G + G+DLE K V E+ ++P+I+SGGAG+ + + +D+D AS+ H ++ + Sbjct: 176 KEGTKKGFDLELNKAVAELVNIPVISSGGAGSTKDIVHLCESSDIDAVAIASILHYKLES 235 Query: 241 IGELKAYLATQGVEIRI 257 + E+K L +++RI Sbjct: 236 VSEIKKTLINNKIKVRI 252 >UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Arcobacter butzleri RM4018 RepID=A8ESN1_ARCB4 Length = 256 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 89/254 (35%), Positives = 141/254 (55%), Gaps = 7/254 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+IPCL + G + K +F+ IGD + K + E+ DEL+F DI AS + R Sbjct: 2 MLQKRVIPCLLLHKGGLYKTEKFKKPTYIGDPINAIKIFNEKEVDELMFIDIDASVEDRE 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + +A +P C GG+K++E KI + G +K+SI+S A+ +P LI A F Sbjct: 62 PNYKMIEDIASECFMPLCYGGGVKNIEQMKKIYALGVEKVSISSQAIINPNLIKEAARLF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q ++V ID D K + + T+ +D++++V+ GAGEIV+N + Sbjct: 122 GNQSVIVTIDIKKDFWGNKK-----IFINNGKKNTKLNPIDFIKQVESLGAGEIVINSCD 176 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF-HKQII 239 DG+ GYD+E LK+++E VP+IA GGAG + H + F + VD S+F ++ + Sbjct: 177 NDGIMKGYDIELLKEIKENTKVPIIALGGAGNLNHIKDVFESSKVDAVACGSMFVYQGPL 236 Query: 240 NIGELKAYLATQGV 253 G L +Y + Q + Sbjct: 237 K-GVLISYPSYQKI 249 >UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=17 Tax=Epsilonproteobacteria RepID=HIS4_CAMHC Length = 236 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 103/244 (42%), Gaps = 16/244 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRN---HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+++G V+ + LA+++A+ GA L D+ + G Sbjct: 1 MEILPAIDLKNGFAVRLKKGEMNSAKIYSDKPWELAEKFADLGAKWLHIVDLDGAFAGEA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ + ++ V GGI+ E + G + + S AL +P + ++A ++ Sbjct: 61 KNAKTIEKIVKSTNLKIEVGGGIRDEERIKFYKNSGVSRFILGSAALKNPEFVKQMAKKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I VGID N + E V+ + + + G I+ ++ Sbjct: 121 ---KIAVGIDAK----------NGFVATEGWAEVSNIKACELAKIYADAGVEAIICTDIS 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ +G +++ +++ + + IASGG + + + G + +++ I+ Sbjct: 168 KDGMLSGVNVKFSEEIAKSSGIKTIASGGVKDLSDIKALKQSGKIYGVIVGKAYYEGSID 227 Query: 241 IGEL 244 + E Sbjct: 228 LKEA 231 >UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Alteromonadales RepID=HIS4_COLP3 Length = 261 Score = 216 bits (551), Expect = 6e-55, Method: Composition-based stats. Identities = 55/250 (22%), Positives = 103/250 (41%), Gaps = 14/250 (5%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSD 57 M+ IP +D+ G+VV+ Q + + YAE GA + F D+ + D Sbjct: 1 MM----IPAIDLIGGEVVRLYQGDYAQKTNYQYTVQDRQQAYAESGATVMHFVDLDGAKD 56 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + V + V GG++ +D ++L+ GAD++ I S A+ P L+T+ Sbjct: 57 STKRQLKTLKTVVNHPSMIIQVGGGVRCEDDVKQLLALGADRVVIGSLAIKQPELVTQWV 116 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 +G + IV+ +D DA+ K + D + + Q G ++ Sbjct: 117 KTYGCEKIVLALDIKIDAQGNK-----TLPTHGWIEDSGVNLEDLLAQYQDAGIKHVLCT 171 Query: 178 MMNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +++DG G +++ +V + + ASGG G++ +A V G + + Sbjct: 172 DISKDGTLTGTNVDLYSEVCAKYPDIDWQASGGIGSLADI-KALIPTGVSGVILGRSLLE 230 Query: 237 QIINIGELKA 246 + E A Sbjct: 231 GKFTLEEAIA 240 >UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7I5_9DELT Length = 289 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 79/238 (33%), Positives = 117/238 (49%), Gaps = 5/238 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + RIIP LD++ +VKG+ F ++G A+ Y E GADEL F D AS R Sbjct: 1 MKFRIIPRLDIKGPNLVKGIHFEGLRVLGKPEDFARHYYENGADELFFQDAVASLYDRNS 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V R + I IP CV GG++S++D +L GADK++IN+ A+ P LI + FG Sbjct: 61 LHDIVKRTSSEIFIPLCVGGGLRSVDDIRAVLRAGADKVAINTEAIKRPELIREASVAFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 IVV I+ A + +Y T ++W + + GAGE+++ ++Q Sbjct: 121 SSTIVVSIEAIRRANGEWEALVEY-----GRETTGVNAVEWAKRACELGAGELMITSIDQ 175 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +G GYD+E + + VP+IA GG G+ D ASV H + I Sbjct: 176 EGTGKGYDIELTRAIASAVSVPVIAGGGCGSPADAANVITQGRADAVSMASVLHYKTI 233 >UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJR2_DESAA Length = 262 Score = 215 bits (549), Expect = 8e-55, Method: Composition-based stats. Identities = 95/265 (35%), Positives = 137/265 (51%), Gaps = 13/265 (4%) Query: 1 MLAKRIIPCLDVRD---GQ-----VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI 52 ML KR+IP L +R G+ +V V F IGD V AK Y + ADELVF D+ Sbjct: 1 MLKKRLIPKLQMRAASFGKTKRMVLVTTVGFGPSTEIGDPVSQAKIYQAQAADELVFLDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 AS + R +++ AE I +P V GG++S+ED ++L+ GADK+SIN+ A+ P L Sbjct: 61 DASIEHRDALTDIIAKAAEEIFMPITVGGGVRSVEDCRRLLNHGADKVSINTGAMEIPEL 120 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I + +D FG QCIVV ID T + + W E Q RGAG Sbjct: 121 INQGSDMFGAQCIVVSIDYKKHPNGAY-----EVFTRGGKSSTGLDPVAWAVEAQHRGAG 175 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 EI+L +++DG R G +LE KV +P+I SGG G HF++ F A + Sbjct: 176 EILLTSIDRDGTRKGLNLELTAKVAGAVDIPVITSGGCGLASHFVDGFLVGKAHAVSAGT 235 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 F + N + ++ ++ G+ IR+ Sbjct: 236 YFCFKDENPMQTRSRISNAGIPIRL 260 >UniRef50_P72139 Putative imidazole glycerol phosphate synthase subunit hisF2 n=9 Tax=cellular organisms RepID=HIS62_PSEAE Length = 251 Score = 215 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 88/255 (34%), Positives = 141/255 (55%), Gaps = 5/255 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M+ +R+IPCL ++D +VK V+F+ + +GD + + + E+ DEL+ DI AS + Sbjct: 1 MVRRRVIPCLLLKDRGLVKTVKFKEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQE 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ VA +P C GGIK+LE A KI S G +K+SIN+ AL D +LI R+AD+F Sbjct: 61 PNYELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V ID G E+ TR + L+W Q +++ G GEI LN ++ Sbjct: 121 GSQSVVGSIDCRKGFWGG-----HSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DGV+ G+D ++ + HVP+IA GGAG++ ++ F V A S+F + Sbjct: 176 RDGVQKGFDNALVENIASNVHVPVIACGGAGSIADLIDLFERTCVSAVAAGSLFVFHGKH 235 Query: 241 IGELKAYLATQGVEI 255 L +Y +++ Sbjct: 236 RAVLISYPDVNKLDV 250 >UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6X1_NATTJ Length = 246 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 51/257 (19%), Positives = 114/257 (44%), Gaps = 19/257 (7%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 ++ +IP +D+ +G+ V+ + + +A+ + E+GA L D+ + G Sbjct: 1 MSLELIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 V + + + ++A + IP V GGI+S+E ++++ G D++ + + A D + + Sbjct: 61 SVKNSTIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 F IV D + GK + V+ +T D++ E+ + G ++L Sbjct: 121 LFHKNIIVG-----VDIKGGKVATEGWV------NVSDTKTYDYLSELTELGVPRVILTD 169 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-----DADVDGALAASV 233 +++DG G +LE K++ + L+ SGG ++E + ++ G + Sbjct: 170 ISKDGKLQGPNLELFKELAIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKA 229 Query: 234 FHKQIINIGELKAYLAT 250 ++ I++ + Sbjct: 230 LYEGKIDLQGALETIRK 246 Score = 54.5 bits (130), Expect = 4e-06, Method: Composition-based stats. Identities = 18/112 (16%), Positives = 41/112 (36%), Gaps = 5/112 (4%) Query: 142 VNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGY--DLEQLKKVREV 199 V G+ +V D + Q++GA + L ++ +G G + ++K+ Sbjct: 17 VRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHL--VDLEGAFQGSVKNSTIIEKIANK 74 Query: 200 CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQ 251 +P+ GG ++E +E + VD + + + + Sbjct: 75 VSIPVQVGGGIRSIE-AIERLVNMGVDQVILGTKAYNDRDFLQSALELFHKN 125 >UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Clostridia RepID=HIS4_SYNWW Length = 244 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 61/253 (24%), Positives = 117/253 (46%), Gaps = 15/253 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D++DGQ V+ VQ R +A+ + E+GA L D+ + G Sbjct: 1 MIIYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + +A IDI F V GG++ L D K+L+ GA ++ I + A++ P I L D+F Sbjct: 61 QNLKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IV+G+D G V + + +D+ +++ G + ++ Sbjct: 121 GPERIVLGLDAK----EGMVAVEGWVST------SSVSAIDFGLQMKALGIQTAIYTDVS 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVFHKQI 238 +DG+ G +L +K++ + +IASGG ++++ + + V GA+ + Sbjct: 171 RDGLLQGPNLAAIKEMASSTGLDIIASGGVSSLDNIRALKELENDGVSGAIIGKALYDGK 230 Query: 239 INIGELKAYLATQ 251 I + + ++ Sbjct: 231 IGLVDALREAESK 243 >UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picrophilus torridus RepID=Q6KZD5_PICTO Length = 249 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 92/257 (35%), Positives = 147/257 (57%), Gaps = 8/257 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLAKRII LDVR+G+VVKGV+F + + GD V A Y ++GADE+VF DI+A+ + R Sbjct: 1 MLAKRIIAALDVRNGRVVKGVRFMDIKDAGDPVENAVIYQDQGADEIVFLDISATDEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V V+ ++IPF V GGI+S++ A +L G DK+ +N+ A+ +P +I ++ Sbjct: 61 IMIDLVKSVSRELNIPFTVGGGIRSVKTALNLLREGCDKVFLNTYAIENPWIIKEISRET 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G +V+ +D Y+ Y + + + +W+ + GAGEI+L ++ Sbjct: 121 GSANLVIAVDAMYNNG-------YYVYKNAGRINSGLKLNEWLPMAEYLGAGEILLTSID 173 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG G+D + + + +P+IASGGAG EHFL+AF A S+ H +I Sbjct: 174 SDGTMKGFDNRLISEAASMIDIPVIASGGAGKPEHFLDAFMAGASGALAA-SILHFKINT 232 Query: 241 IGELKAYLATQGVEIRI 257 + ++K YL + GV +R+ Sbjct: 233 VNDIKRYLRSNGVNVRL 249 >UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=97 Tax=Gammaproteobacteria RepID=HIS4_YERP3 Length = 245 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 56/245 (22%), Positives = 108/245 (44%), Gaps = 10/245 (4%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD+ +G+VV+ Q G+ +P + Y ++GA L D+T + D Sbjct: 2 IIPALDLIEGKVVRLHQGDYGQQRDYGNHPLPRLQDYQQQGAQVLHLVDLTGAKDPAARQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +D+P V GGI++ +D +L GA ++ + S A+ P ++ + +R+G Sbjct: 62 IPLLRELLAGVDVPVQVGGGIRNEQDVVALLEAGAARVVVGSTAVKQPEMVQQWFERYGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+ +D + K + + V++ G ++ +++D Sbjct: 122 EAIVLALDVRINEAGCK-----HVAISGWQENSDATLEQIVEQYLPYGLKHVLCTDISRD 176 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G +G ++E ++V + V ASGG G ++ R + V G + N+ Sbjct: 177 GTLSGSNVELYQEVCQRYPQVAFQASGGIGCLDDIAR-LRGSGVQGVIVGRALLDGKFNV 235 Query: 242 GELKA 246 E A Sbjct: 236 KEAIA 240 >UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=35 Tax=cellular organisms RepID=HIS4_GRAFK Length = 241 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 109/252 (43%), Gaps = 15/252 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 RIIP +D+ +G+ V+ + D + +AK + G + L D+ + + Sbjct: 1 MRIIPAIDIIEGKCVRLSKGDYATKKIYNEDPLEVAKSFEAHGIEYLHLVDLDGAKSSHI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + +A + GG+K+ +D GA +I+ S A+ + + +F Sbjct: 61 VNHKILETIANKTSLKIDFGGGLKTDKDLQIAFESGASQITGGSIAVKNSDVFQNWIQKF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I++G D K V+ + + E + ++Q +++G ++ ++ Sbjct: 121 GNKKIILGADAK----DRKIAVSGWL------EDSNEEIIPFIQNYEEKGVKYVICTDIS 170 Query: 181 QDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G E K++ ++ LIASGG + + + +G + ++ I Sbjct: 171 KDGMLEGPSFELYKEILSETKNINLIASGGISEFDELPK-LAELGCEGVIIGKAIYENRI 229 Query: 240 NIGELKAYLATQ 251 ++ + + Y+ Q Sbjct: 230 SLKQFENYILNQ 241 >UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Proteobacteria RepID=HIS4_NITSB Length = 238 Score = 214 bits (545), Expect = 2e-54, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 104/250 (41%), Gaps = 16/250 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D++DG+ V+ + + +AKR+ E G+ L D+ + G Sbjct: 1 MEILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ + + GGI+ E K + G +++ + S A+ +P + +A ++ Sbjct: 61 KNLEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I VGID ++ + E + + D +E K G I+ + Sbjct: 121 P---IAVGID----------AIDGFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVG 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G +++ + E + IASGG +E + V G + F++ ++ Sbjct: 168 KDGTLSGVNVDFTVSIAEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLD 227 Query: 241 IGELKAYLAT 250 + E + Sbjct: 228 LEEAFRLVQN 237 >UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Halobacteriaceae RepID=HIS4_HALWD Length = 245 Score = 213 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 112/250 (44%), Gaps = 14/250 (5%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRN--HEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + +IP +D++DG VV+ VQ GD V AK++ E GA L D+ + +G Sbjct: 7 SFEVIPAVDMQDGDVVQLVQGERGTETRYGDPVVAAKQWVEAGAKTLHLVDLDGAFEGDR 66 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + V + + +DIP + GGI++ DAA +L G +++ + + A+ +P L+ LA+ + Sbjct: 67 MNATAVDAIIDAVDIPVQLGGGIRTANDAASLLDRGVNRVILGTAAVENPDLVAELAESY 126 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + IV DA G+ V+ + T T + GA I+ ++ Sbjct: 127 PGRIIV-----SLDAADGEVVVSGW------TESTGIDPAVAAARFADYGACGILFTDVD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G G +V + +P+IASGG +++ + + + ++ Sbjct: 176 VEGKLAGIQSSVTARVIDAVDIPVIASGGVASLDDI-QTLHTTGAAATVVGTALYENKFT 234 Query: 241 IGELKAYLAT 250 + + + Sbjct: 235 LADAMEVCES 244 Score = 66.4 bits (161), Expect = 8e-10, Method: Composition-based stats. Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 2/119 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 RII LD DG+VV V D A R+A+ GA ++F D+ + S Sbjct: 129 RIIVSLDAADGEVV--VSGWTESTGIDPAVAAARFADYGACGILFTDVDVEGKLAGIQSS 186 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 +RV + +DIP +GG+ SL+D + + GA + + + + + Sbjct: 187 VTARVIDAVDIPVIASGGVASLDDIQTLHTTGAAATVVGTALYENKFTLADAMEVCESD 245 >UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Leptospirillum RepID=A3EUM5_9BACT Length = 247 Score = 213 bits (544), Expect = 4e-54, Method: Composition-based stats. Identities = 52/248 (20%), Positives = 107/248 (43%), Gaps = 15/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++ P +D+R+G+VV+ Q R D V A ++ E G L D+ + +G Sbjct: 1 MQLYPAIDIRNGKVVRLTQGRFDQETVYGEDPVRTALQFRERGVQHLHVVDLDGAREGVP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V++S + + + V GG++S + A+ G ++ + + A+ DP + + ++ Sbjct: 61 VNRSLIREIVKAFRGFVQVGGGVRSKDIASFYYDAGVSRLILGTAAIKDPVFLGSMIEQH 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 VGID ++ + + L+ + + + G V ++ Sbjct: 121 P-DLFYVGIDVKDES----------LAVNGWLDLDTQDPLEVMVRMSELGVRGFVYTDIH 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ +G + + + +R VP+IASGG + R+ VDGA+ + ++ Sbjct: 170 RDGLLSGPNFARYETLRRTVRVPVIASGGVRDISDIAR-LREIGVDGAIVGKAIYTGEMD 228 Query: 241 IGELKAYL 248 + E L Sbjct: 229 LTEALRLL 236 Score = 58.7 bits (141), Expect = 2e-07, Method: Composition-based stats. Identities = 20/112 (17%), Positives = 40/112 (35%), Gaps = 2/112 (1%) Query: 10 LDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRV 69 +DV+D + V D + + R +E G V+ DI + + + Sbjct: 128 IDVKDESL--AVNGWLDLDTQDPLEVMVRMSELGVRGFVYTDIHRDGLLSGPNFARYETL 185 Query: 70 AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + +P +GG++ + D A++ G D + +T G Sbjct: 186 RRTVRVPVIASGGVRDISDIARLREIGVDGAIVGKAIYTGEMDLTEALRLLG 237 >UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW7_9FIRM Length = 243 Score = 213 bits (544), Expect = 4e-54, Method: Composition-based stats. Identities = 56/254 (22%), Positives = 113/254 (44%), Gaps = 16/254 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+R G+ V+ ++ +AK++ +GA L D+ + GR Sbjct: 1 MIIFPAIDIRGGKCVRLLKGDFAKETVFSDKPEEMAKKWQTQGAQFLHLVDLDGALAGRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V + +DIP + GGI++LE ++L+ G ++ + S A+ DP L+ ++ Sbjct: 61 QNLATVKAILAAVDIPVELGGGIRTLESIDEVLALGVRRVILGSVAVRDPELVKTACAKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + +V DA+ G V+ + E +E++K G I+ ++ Sbjct: 121 GDRIVVG-----IDAKDGIVAVDGWG------VSGDVEATALAKEMKKAGVKTIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG G ++E K+ V ++ASGG ++ + A ++G + + Sbjct: 170 RDGTLAGVNVEATAKLARESGVAVVASGGVKSIADIEALKPYEKAGIEGVIVGKSIYMGT 229 Query: 239 INIGELKAYLATQG 252 +++ E A +G Sbjct: 230 LDLAEAIEIAAKEG 243 >UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase subunit hisF2 n=17 Tax=delta/epsilon subdivisions RepID=HIS62_CAMJJ Length = 248 Score = 213 bits (543), Expect = 4e-54, Method: Composition-based stats. Identities = 92/258 (35%), Positives = 136/258 (52%), Gaps = 10/258 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML RIIPC+ +++GQ+VK ++F++ IG + + Y DEL+ DI AS G Sbjct: 1 MLKTRIIPCVLLKNGQLVKSIEFKDFRTIGHLTSTMRIYNARNVDELIILDIDASKSGE- 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +D + +A+ +P + GGIK+LED KIL+ GADKISINS AL D I++ A+RF Sbjct: 60 IDFESIEDLAKECFMPLTIGGGIKTLEDIQKILNLGADKISINSKALEDMDFISKAANRF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV ID + ++ L+ E +K+GAGE++L ++ Sbjct: 120 GSQCIVCSIDVKRKGGQFCVYDRGNLLEK--------SPLELALEYEKKGAGELLLTSVD 171 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G GYDLE LK + +PLI +GG +EA + D A +FH Sbjct: 172 FEGRAKGYDLELLKIFQNKLKIPLIINGGLSNPSDGVEAL-NLGADALAGAYIFHFSKYT 230 Query: 241 IGELKAYLATQGVEIRIC 258 ++K LA QG +R+ Sbjct: 231 PKDVKEELARQGFAVRLL 248 >UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=92 Tax=Proteobacteria RepID=HIS4_ACTP2 Length = 250 Score = 212 bits (541), Expect = 7e-54, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 106/245 (43%), Gaps = 10/245 (4%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD+ DG VV+ Q + + Y +GA++L D+T + Sbjct: 7 IIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFANYLAQGAEQLHLVDLTGAKYPAKRQ 66 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + V GGI++ +D A +L+ GA+++ I S A+ D ++ +++G Sbjct: 67 TALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYGA 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V+ +D DA K + + +++ Q G ++ +++D Sbjct: 127 EKFVLALDVNIDASGQKI-----IAISGWQEASGVSLEELIEDYQVVGLQHVLCTDISRD 181 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G ++ +++ + + +SGG G+++ +A + V G + + N+ Sbjct: 182 GTLAGSNVNLYREICAKYPKIHFQSSGGIGSLDDI-KALKGTGVSGVIVGRALLEGKFNV 240 Query: 242 GELKA 246 E Sbjct: 241 AEAIE 245 >UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Thermus RepID=HIS4_THET2 Length = 235 Score = 212 bits (539), Expect = 1e-53, Method: Composition-based stats. Identities = 66/243 (27%), Positives = 105/243 (43%), Gaps = 14/243 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+IP +D++ G+ V+ + GD V A R+ EEGA L D+ + G Sbjct: 1 MRLIPAVDLKSGKAVRLYEGDPARETPYGDPVEAALRFQEEGATLLHLVDLDRAL-GTGE 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 ++ V RVA + IPF +AGGI+SLE + LS GA + + + A+ DP L+ R+ + G Sbjct: 60 NREAVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVG 119 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V +D LD ++ + G ++ + + Sbjct: 120 PDRLAVALDAR----------GLEVVVSGWQEAASASALDLLRAWAEMGVRTLLYTDVRR 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G D E + +VR LI GG + E + VDGAL ++ I + Sbjct: 170 DGTLLGLDREVVARVRAAWPHELIVGGGIASPEDL-HLLQALGVDGALIGKALYEGRIRL 228 Query: 242 GEL 244 E Sbjct: 229 KEA 231 Score = 54.1 bits (129), Expect = 4e-06, Method: Composition-based stats. Identities = 28/115 (24%), Positives = 42/115 (36%), Gaps = 2/115 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 R+ LD R +VV V + L + +AE G L++ D+ +D+ Sbjct: 122 RLAVALDARGLEVV--VSGWQEAASASALDLLRAWAEMGVRTLLYTDVRRDGTLLGLDRE 179 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V+RV V GGI S ED + + G D I + R Sbjct: 180 VVARVRAAWPHELIVGGGIASPEDLHLLQALGVDGALIGKALYEGRIRLKEAVWR 234 >UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrionales RepID=HIS4_DESDA Length = 250 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 56/255 (21%), Positives = 110/255 (43%), Gaps = 17/255 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+++G+ V+ Q R + V A+ + E GA L D+ + DG Sbjct: 1 MIIFPAVDIQNGKAVRLKQGRAHESTVFAESPVDAARAWEEAGARWLHVVDLDGAFDGAA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V + + IP + GGI+ + A L G ++ I + AL PTL + F Sbjct: 61 QSRRIVRDICAALAIPVQLGGGIRDMHTAEAYLEAGVSRLIIGTLALEQPTLFADMCRAF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + V DAE G+ + T + + GA ++ + Sbjct: 121 PGRVGV-----SLDAEGGRLKSRGWV------EDTGMTVDTALPRLLDDGAAFVIYTDIE 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF---RDADVDGALAASVFHKQ 237 +DG++ G ++ L+ + + VP+IA+GG T+E + + + + GA++ ++ Sbjct: 170 RDGMQCGVNVAALEHLARLSTVPVIAAGGVATLEDIQKLYPLTLETSLMGAVSGRALYEG 229 Query: 238 IINIGELKAYLATQG 252 +++ E A++ + Sbjct: 230 TLDLKEANAWIDARK 244 >UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Thermoanaerobacter RepID=HIS4_THEPX Length = 235 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 49/248 (19%), Positives = 110/248 (44%), Gaps = 16/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ + + V+ + + V +AK + E GA + D+ + G + Sbjct: 1 MVLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + ++ + V GGI++ E + S G + + S A+ D L+ + Sbjct: 61 VNGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + IV D++ G+ V+ + T+ + ++ +++++ G I+ ++ Sbjct: 121 GERTIVG-----IDSKNGEVAVSGWL------EKTKIKDMELAKKMKEIGVKTIIFTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG NG + + L+ + + V +IASGG ++E + ++ GA+ + IN Sbjct: 170 KDGTLNGPNFKALENILK-TGVQVIASGGISSIEDLKK-LKEMGAYGAIIGKALYIGKIN 227 Query: 241 IGELKAYL 248 + Sbjct: 228 FKSALEVI 235 >UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Listeria grayi DSM 20601 RepID=C2BYH3_LISGR Length = 240 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 115/246 (46%), Gaps = 15/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D+++G+ V+ Q + D + A ++A GA L D+ + G+ Sbjct: 1 MQIFPAIDIKNGKCVRLYQGDFAKETMMNADPIDQAAKFAAAGATFLHIVDLDGAVSGKP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + R+ + + IP V GGI+++ L GA+++ I S AL+DP + ++ Sbjct: 61 TNIALIQRLQQQVKIPIQVGGGIRTMTQVDTYLRAGAERVIIGSAALSDPDFVKAAVTKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I++GID N + E +++ + + E+ K G I+ ++ Sbjct: 121 GDK-IIIGIDAK----------NGFVATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G + E+L+ +++ + +IASGG + E GA+A ++ I Sbjct: 170 KDGTLAGPNFEELRAIQKSARIAVIASGGVSSKADL-EQLAAEGFYGAIAGKALYEGKIT 228 Query: 241 IGELKA 246 + ++ Sbjct: 229 MADVLE 234 Score = 43.3 bits (101), Expect = 0.007, Method: Composition-based stats. Identities = 17/119 (14%), Positives = 40/119 (33%), Gaps = 2/119 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 +II +D ++G V + A A+ G + +++ DI+ + Sbjct: 123 KIIIGIDAKNGFV--ATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDISKDGTLAGPNFE 180 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + + I +GG+ S D ++ + G + + + G Sbjct: 181 ELRAIQKSARIAVIASGGVSSKADLEQLAAEGFYGAIAGKALYEGKITMADVLEVEGHA 239 >UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_CLOK1 Length = 238 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 53/247 (21%), Positives = 117/247 (47%), Gaps = 15/247 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D++ G+ V+ + + D A ++ EGA L D+ + G Sbjct: 1 MIILPAIDLKGGKCVRLYKGDMNSQEVVARDPFETALKFKSEGAQYLHMVDLDGALKGSG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + +S++ + +D+P V GGI+++E K + G ++ + + AL + L+ + + + Sbjct: 61 ENLDIISKIVKNVDVPIEVGGGIRNIETIDKFIKLGVSRVILGTAALKNKELVIKAVENY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I VGID + + T +++ +D+ +E++K G ++ ++ Sbjct: 121 -DEKIAVGIDAK----------DGVPAADGWTTLSKTNYIDFGKEMEKIGVQTLIFTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G +LEQL K++ +IASGG +E ++ + +V GA+ + + ++ Sbjct: 170 KDGTLEGTNLEQLLKLKNSVKCNVIASGGIKDIEDI-KSLKKENVYGAIVGKAIYAKTLS 228 Query: 241 IGELKAY 247 + + Sbjct: 229 LKKAIEI 235 Score = 48.7 bits (115), Expect = 2e-04, Method: Composition-based stats. Identities = 18/113 (15%), Positives = 37/113 (32%), Gaps = 2/113 (1%) Query: 10 LDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRV 69 +D +DG V + + K + G L+F DI+ + + ++ Sbjct: 128 IDAKDG--VPAADGWTTLSKTNYIDFGKEMEKIGVQTLIFTDISKDGTLEGTNLEQLLKL 185 Query: 70 AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +GGIK +ED + + A + + + G Sbjct: 186 KNSVKCNVIASGGIKDIEDIKSLKKENVYGAIVGKAIYAKTLSLKKAIEIGGN 238 >UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Bacteria RepID=C5BRY3_TERTT Length = 259 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 96/252 (38%), Positives = 140/252 (55%), Gaps = 5/252 (1%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 R I LDV+ Q++K + ++GD AKRY E+GADEL++ D+ AS GR K Sbjct: 10 RFIARLDVKGDQLIKAIHLEGLRVVGDPQIYAKRYYEQGADELLYIDLVASLYGRNKLKD 69 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 VSR A+ I IP V GGI+S+ED ++L+ GADK++IN+ A+A+P LI ++A RFG QC Sbjct: 70 IVSRTAQDIFIPLTVGGGIRSVEDVTELLAAGADKVAINTAAVANPALIEQVALRFGSQC 129 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 +V+ I+ E ++ V + + + W +E +RGAGEI+L ++Q+G Sbjct: 130 MVLSIEAKRLGED-RWEVYTDCA----RESSGRDVIAWAKEAVERGAGEILLTSIDQEGT 184 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 R G+D V E VP+IASGG G EH + A H + I L Sbjct: 185 RKGFDTALTAAVAETVRVPVIASGGYGQPEHINAITHQGSANAIAFADALHFERETIASL 244 Query: 245 KAYLATQGVEIR 256 K+Y A G+ +R Sbjct: 245 KSYGAEAGLRVR 256 >UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Nannocystineae RepID=D0LIZ1_HALO1 Length = 239 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 94/251 (37%), Gaps = 15/251 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I P +D+ G VV+ Q + E + + +R+A GA+ + D+ + G Sbjct: 1 MKIYPAIDLLGGNVVRLHQGKRSEALVYSNEPAEIVRRFASAGAERVHVVDLDGAFSGER 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ +A +P V GGI+ + + GA + + A+ +P Sbjct: 61 AHREALAEMAAASPVPLQVGGGIRDRAALEAVFATGAGFAVLGTAAVKNPAFAREACAAH 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 IV DA G + + + + GA ++ + Sbjct: 121 PGCVIVA-----VDARDGVVAIEGWV------ESAGITAEELGKRAADWGAAGLLYTDVM 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + G ++ + + +P+IASGG GT++ A A V + ++ Sbjct: 170 RDGAQVGPNIATTAALAQAVDIPVIASGGVGTLDDI-RALAAAGVPSVVVGRALYENKFT 228 Query: 241 IGELKAYLATQ 251 + E A + Sbjct: 229 LPEALAAARGE 239 >UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=HIS4_UNCTG Length = 244 Score = 210 bits (535), Expect = 3e-53, Method: Composition-based stats. Identities = 57/252 (22%), Positives = 113/252 (44%), Gaps = 16/252 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+R G V+ Q D V +AK + +GA L D+ + G Sbjct: 1 MIIIPAVDIRQGNSVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++K+ + + +DIP V GGI++++ ++ GA + + A +P ++ + R+ Sbjct: 61 INKAIIKNICAAVDIPVEVGGGIRNMDKIKEVFDIGAAYAILGTVAFNNPEIVKKAITRY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I+V +D + +T E + V ++++ G EI+ ++ Sbjct: 121 GSEKIIVAVDAK----------DGKVAISGWKDITPIEASELVNKLKEIGVQEILYTDIS 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG+ G D LKK+ E + +IASGG T+++ ++ + V A+ S + Sbjct: 171 RDGMFTGPDFAGLKKLSE-SGMRIIASGGVKTIDNLVKLKKYEKDGVFAAIVGSALYTDD 229 Query: 239 INIGELKAYLAT 250 + + + Sbjct: 230 FKLEDAIEEIEG 241 Score = 49.1 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 14/115 (12%), Positives = 39/115 (33%), Gaps = 1/115 (0%) Query: 141 HVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVC 200 V G+ + + + + + +GA + + ++ + +K + Sbjct: 14 SVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTNINKAIIKNICAAV 73 Query: 201 HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEI 255 +P+ GG M+ E F D A+ +V + + ++ + + Sbjct: 74 DIPVEVGGGIRNMDKIKEVF-DIGAAYAILGTVAFNNPEIVKKAITRYGSEKIIV 127 >UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hisF n=24 Tax=cellular organisms RepID=HIS6_HALS3 Length = 273 Score = 210 bits (535), Expect = 4e-53, Method: Composition-based stats. Identities = 112/268 (41%), Positives = 146/268 (54%), Gaps = 14/268 (5%) Query: 2 LAKRIIPCLDVR---DGQ--VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASS 56 L KR+IPC+DV DG+ V GV F GD V +AKRY E GADE VF DITAS+ Sbjct: 3 LTKRVIPCIDVDLDDDGEPAVYTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASA 62 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 +GR VS VA+ + IP V GGI+ +D + L GADK+SINS A+ADP+L+ R Sbjct: 63 EGRETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRG 122 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYH--------VNQYTGDESRTRVTQWETLDWVQEVQK 168 A FG QCIV+ +D + H T + ++WVQE Q+ Sbjct: 123 AKAFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREGTGMDAIEWVQEAQR 182 Query: 169 RGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGA 228 RGAGE+ +N ++ DG ++GYD+ V + P+IAS G G + DA D A Sbjct: 183 RGAGELFVNSIDADGTQDGYDVPLTAAVCDAVSTPVIASSGCGAPG-DMADAYDAGADAA 241 Query: 229 LAASVFHKQIINIGELKAYLATQGVEIR 256 LAAS+FH +I E K LA G IR Sbjct: 242 LAASIFHFDEYSIAETKETLADAGYPIR 269 >UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBX0_9FIRM Length = 234 Score = 209 bits (533), Expect = 6e-53, Method: Composition-based stats. Identities = 41/245 (16%), Positives = 110/245 (44%), Gaps = 15/245 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+RD + V+ Q + + +A+ + + G L D+ A+ G++ Sbjct: 1 MIIFPAIDIRDNKCVRLSQGDYDKQTVYFDNPFTVAEDFEKRGVKYLHIVDLDAALIGKL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ ++ V GGI+ E K + G D++SI + A+ D + +++++ Sbjct: 61 TNFDIIKKIITDTNMLIEVGGGIRGEEQIKKYVDIGVDRVSIGTKAVKDFAFLKEMSEKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I + +D ++Y + + + D++ +++ IV+ + Sbjct: 121 PYK-ISLSLDVK----------DEYVYIKGWSENSGILIWDYLDKIKDLPLTGIVVTDIK 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ +G E +K+++ ++ SGG +++ + ++ D G + ++ + Sbjct: 170 KDGMLSGPSFELYRKLKKATKHNIVVSGGVSSLDDINK-LKEDDTYGVIVGKALYENKFS 228 Query: 241 IGELK 245 + ++ Sbjct: 229 VEDII 233 >UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=C7PAV4_CHIPD Length = 389 Score = 209 bits (533), Expect = 7e-53, Method: Composition-based stats. Identities = 55/248 (22%), Positives = 103/248 (41%), Gaps = 15/248 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q + +AK + G L D+ + G VV+ Sbjct: 148 VIPAIDIIDGKCVRLTQGDYAQKKVYNEHPLEVAKAFESIGIRRLHLVDLDGAKKGAVVN 207 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + +A ++ GGIK+ +D + GA +I S A+ DP L + ++G Sbjct: 208 WKVLEAIAGKTNLVIDFGGGIKTEDDLRIVYENGAALATIGSIAVKDPALFSGWVKKYGA 267 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 I +G D + T+ D+++E K+G I + +D Sbjct: 268 DKIFLGADVKEEK----------IAVGGWLETTELSVFDFLEENVKQGVQHIFCTDIAKD 317 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G+ G + +K+ + + +ASGG TM A +A G + +++ I++ Sbjct: 318 GLLQGPSVALYEKILQRFPQIDFVASGGVSTMADV-HALAEAGCSGVIVGKAIYEERISM 376 Query: 242 GELKAYLA 249 EL ++ Sbjct: 377 KELADFIK 384 >UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFDF6 Length = 236 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 45/248 (18%), Positives = 108/248 (43%), Gaps = 15/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 RI P +D+++GQ+V+ + + + D + + + +EGA L D+ + G + Sbjct: 1 MRIFPAIDIKNGQIVRLTEGKYDQVKVYSKDPEEVLEHFTKEGATALHIVDLDGAKSGTI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +++ + + + + GGI+ L+ G D++ + + A+ +P + + ++ Sbjct: 61 ENQNTIKTILKNRHFVTQLGGGIRDESTINHYLNMGVDRVILGTVAVENPKFVEEMVKKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q I VG+D + ++ + +++ + + G I+ ++ Sbjct: 121 -DQQIAVGVDEK----------DGQVRANGWLVNSKVDAIEFCKMLTAMGVATIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G D+ +++ + V +IASGG ++ E + V G + ++ I Sbjct: 170 KDGMMAGCDMASYRQLCKDRKVNIIASGGVTSIAEIKE-LKRIGVAGVIVGKAIYEGKIA 228 Query: 241 IGELKAYL 248 + E A Sbjct: 229 LREATAIC 236 >UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=144 Tax=Bacteria RepID=HIS4_CORJK Length = 258 Score = 208 bits (530), Expect = 2e-52, Method: Composition-based stats. Identities = 57/249 (22%), Positives = 111/249 (44%), Gaps = 13/249 (5%) Query: 6 IIPCLDVRDGQVVKGVQF--RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +DV DGQ V+ VQ G + A + GA+ + D+ A+ GR + Sbjct: 12 LLPAVDVADGQAVRLVQGAAGTETSYGAPIEAALAWQNAGAEWIHLVDLDAAF-GRGSNF 70 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + V +D+ ++GGI+ E + LS G +++I + AL DP + R+G + Sbjct: 71 ELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYGDK 130 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + +G+DT + +T D E + ++ + +G +V+ +++DG Sbjct: 131 -VAIGLDTREVDGEWRLRGRGWTSDGG-------ELWEVLERLDSQGVSRLVVTDVSRDG 182 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVFHKQIINI 241 + NG +++ L++V P++ASGG +++ A VD A+ + + Sbjct: 183 MLNGPNIDLLREVAAATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFTL 242 Query: 242 GELKAYLAT 250 E Sbjct: 243 EEALEAAQG 251 >UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Methanomicrobiales RepID=HIS4_METMJ Length = 239 Score = 208 bits (530), Expect = 2e-52, Method: Composition-based stats. Identities = 61/250 (24%), Positives = 112/250 (44%), Gaps = 14/250 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH--EIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 I P +D+ DG+ V+ VQ R + GD A R+ +EGAD L ++ + Sbjct: 1 MEIYPAVDILDGRCVQLVQGRPEAATVYGDPAAWAHRWLDEGADGLHVVNLDGAFGRARK 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + + GGI+S+EDAA L G D++ +++ A+ +P +I LA+ FG Sbjct: 61 NADLIRAFTRETETFTELGGGIRSVEDAAGWLDAGVDRVIVSTQAVREPEMIRTLAEEFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + ++ GID G+ + + L W + + GAG ++ ++ Sbjct: 121 GERVMAGIDARA----GEVMIEGWERPAG-------SYLSWAERFESLGAGSLLYTNVDV 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 +G++ G +E + ++ VP++ SGG + A RDA GA+ S + + + Sbjct: 170 EGLQQGIAIEPVTELLARVKVPVVVSGGISSPGDV-AALRDAGAAGAVLGSALYAGKVRL 228 Query: 242 GELKAYLATQ 251 E Sbjct: 229 PEAMEAAHAN 238 >UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Proteobacteria RepID=A6T0B3_JANMA Length = 253 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 79/247 (31%), Positives = 136/247 (55%), Gaps = 5/247 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 MLA R++PCL + G +VK VQF+ IGD V + + ++ DEL+ DITA+++ R Sbjct: 1 MLAIRVMPCLLMDQGALVKTVQFKKPTYIGDPVNAVRIFNQKEVDELLLIDITATTEKRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +D + ++ +P C GG+ +L D ++ G +KIS+++ A+ +P L+ A F Sbjct: 61 IDFETLEKLVTECFMPICYGGGVDNLVDMRRLYHLGIEKISLSAAAITNPELVREAAAEF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D + GK+ V + G T+ ++ +E+++ GAGEI+L ++ Sbjct: 121 GNQAIVVTLDVKKNLF-GKHTVRTHQGK----TDTKRSPVEVAREMEQAGAGEILLYSID 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G+DL+ ++ V +P+IA GGAG + H A +A S+ Q + Sbjct: 176 KDGTWSGFDLDLIQNVTRAVGIPVIACGGAGELAHLRSAVNEAGASAVAIGSMAVFQAKD 235 Query: 241 IGELKAY 247 +G L + Sbjct: 236 LGVLIKF 242 >UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=24 Tax=Bacteroidetes RepID=HIS4_PARD8 Length = 239 Score = 207 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 50/248 (20%), Positives = 107/248 (43%), Gaps = 15/248 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ DG+ V+ Q D + +AK + G L D+ + +GR+ Sbjct: 2 IELIPAIDIIDGKCVRLTQGDYATKKVYNEDPLEVAKMFEGNGIRRLHVVDLDGAREGRI 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + R+A + GG+K +D GA ++ S A+ +P + T +F Sbjct: 62 INYRILERIATRTSLIIDFGGGLKQEDDLEIAFESGAQMVTGGSIAVKNPEMFTSWISKF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I++G D T E + +++ +G +++ + Sbjct: 122 GSEKIILGADAKEKK----------IAISGWEETTSQELVPFIKGYYDKGITKVICTDIA 171 Query: 181 QDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG+ G ++ K++R E+ + +IASGG ++E + +A + + ++ I Sbjct: 172 RDGMLQGPAIDLYKEIRDEIPFLYIIASGGVSSIEDIEK-LSEAGIPAVIFGKAIYEGKI 230 Query: 240 NIGELKAY 247 + +L + Sbjct: 231 QLKDLLRF 238 >UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Euryarchaeota RepID=HIS4_METJA Length = 237 Score = 207 bits (526), Expect = 5e-52, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 125/250 (50%), Gaps = 16/250 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D++D + V+ +Q ++ + + V +AK++ +EGA+ L D+ A+ G Sbjct: 1 MIIIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAF-GTG 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + + + +++P V GGI++LE A +++S G D++ + + A+ +P I L Sbjct: 60 NNRDVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEI 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IV+ ++ + ++ ++E + + G I+ ++ Sbjct: 120 GKDKIVLAVECK----------EGKVVIKGWKEKVDKTPIEVIKEFEDK-VGYILFTNVD 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G+ G +++ +K++ E +P+I SGG T+E +A ++ + G + S +K +I+ Sbjct: 169 VEGLLKGINVDIIKELIEKTDIPIIYSGGITTLEDI-KALKELGIYGVVIGSALYKGLID 227 Query: 241 IGELKAYLAT 250 + + + Sbjct: 228 LKKALEIVKN 237 >UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3165B Length = 246 Score = 206 bits (525), Expect = 5e-52, Method: Composition-based stats. Identities = 55/251 (21%), Positives = 110/251 (43%), Gaps = 16/251 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + P +D+R G V+ Q D + A+ + E GA L D+ + DGR Sbjct: 1 MILYPAIDIRGGSAVRLRQGDFADETVYDADPLSAARAWVEGGARWLHVVDLDGARDGRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + R+A + +P GG++S + GA+++ + + A AD + + + Sbjct: 61 ANLEHLRRIAGELGVPVEFGGGLRSRASVDAAIEAGAERVILGTAAFADVDFLDDVVAAY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + +V D GK + T+ E + +Q+RG ++V + + Sbjct: 121 GERVVV-----SVDVRGGKVASAGWK------EQTEMEAAAVIDHLQRRGVRKLVYSNIE 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG+ G DL+++++V E I SGG G+++H R +++G + +++ Sbjct: 170 RDGMLTGPDLDEVRRVAESVRGSFIYSGGIGSLDHLAALASLRQVNLNGVIVGKALYERK 229 Query: 239 INIGELKAYLA 249 +G+ L Sbjct: 230 FTVGDALTALK 240 >UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41EB6 Length = 246 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 48/248 (19%), Positives = 123/248 (49%), Gaps = 15/248 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 I+P +D+R G+ V+ VQ + +I + +AK++ + GA+ + D+ + + Sbjct: 7 KMLIMPAVDIRGGKCVQLVQGKPGSEQVVIENPEKVAKKWEDAGAEVVHVIDLDGALE-S 65 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V + + ++ + +P + GGI+S+E A ++L+ D++ I + + +P +I++L++ Sbjct: 66 VTNIETIKKILNEVSVPIQLGGGIRSIEYAEELLNLDIDRLIIGTMGIKNPEIISKLSNE 125 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 +G + +++ +D ++ K + + + +E Q+ GAG I+ + Sbjct: 126 YGSERVMISLD----SKDNKVVIKGW------QEKIDKSASEISKEFQELGAGSILFTNV 175 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 + +G+ G+ ++ + + + +P++ SGG +++ + + G + S +K I Sbjct: 176 DVEGLLGGFYVDPVIDLVDSVDIPVVYSGGVTSLDDLKQ-LQTTGAKGVVIGSALYKDKI 234 Query: 240 NIGELKAY 247 + + Y Sbjct: 235 KLEDALKY 242 >UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BNI2_9BACT Length = 248 Score = 206 bits (524), Expect = 6e-52, Method: Composition-based stats. Identities = 75/256 (29%), Positives = 128/256 (50%), Gaps = 9/256 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML RIIP L +VK F+N ++G+ V A+ + G DEL+F DI A+ R Sbjct: 1 MLKNRIIPILTFNGLGLVKTKGFKNPRMVGNPVQTARVFNSRGVDELIFLDIYATKQSRK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ S V V + +P + GGI++++ +L GADK+ I S AL D + + F Sbjct: 61 INLSLVKEVIKECYMPVSIGGGIQTIDQINDLLKIGADKVVIKSKALTDKKFLKEAINFF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI + +D + + + +++ E+ AGE+++N +N Sbjct: 121 GSQCICISVDVLFVNNNYLIY---------NDLGLKISLEEFITEMSLINAGELLVNSVN 171 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DGV NG+D++ + KV ++ +P+IA+GG G EH+ F ++ ++S+FH Sbjct: 172 NDGVMNGFDIDLINKVEQMTTIPVIAAGGGGEPEHYSTLFNKTKINAVASSSIFHFTQYT 231 Query: 241 IGELKAYLATQGVEIR 256 ++K L +R Sbjct: 232 PLDIKNELKKFNFPVR 247 >UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Prochlorococcus marinus str. MIT 9313 RepID=HIS62_PROMM Length = 261 Score = 206 bits (524), Expect = 7e-52, Method: Composition-based stats. Identities = 82/265 (30%), Positives = 139/265 (52%), Gaps = 14/265 (5%) Query: 1 MLAKRIIPCLD--VR------DGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI 52 ML KR+IP L ++ +V QF + IGD V AK Y + ADELV D+ Sbjct: 1 MLKKRLIPKLQFSIKPSYRGPKPVLVITRQFDSKRAIGDPVSQAKIYEAQLADELVLVDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 +SD + +S ++E + P V GGI S E ++L GADK+ +NS A+ +P L Sbjct: 61 EGTSDSWPILLDTLSNMSESLATPLSVGGGITSFEQVQQLLDRGADKVVLNSGAVNNPQL 120 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I +A+ +G QC+V+ ID +++ + + + + T W W + RGAG Sbjct: 121 IDLVANSYGSQCVVISIDIRKESDLSR-----HVYIDGGSTATDWSLFSWANDCASRGAG 175 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 E+++ ++ DG G DL+ ++++R ++PLIASGG G +HF+ + A + Sbjct: 176 ELLITSIDNDGTGTGLDLDSIRQLRYEVNLPLIASGGCGLAQHFVAG-YEVGASAVAAGT 234 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 F ++ N + ++++ G+ IR+ Sbjct: 235 FFSQRDQNPMQCRSHIRNAGLPIRL 259 >UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Firmicutes RepID=HIS4_CLOBA Length = 237 Score = 206 bits (524), Expect = 8e-52, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 120/247 (48%), Gaps = 15/247 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+ DGQ V+ Q + DI +AK + GA+ + D+ + G Sbjct: 1 MIILPAIDIIDGQAVRLYQGDYNKKEVVANDIFNIAKEFECLGAEYIHLVDLDGAKSGYC 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V++ + ++A+ +D+P V GGI++ E K++ G ++ + + A+ D L+ + + + Sbjct: 61 VNEKIILKLAQTVDVPIEVGGGIRNFETIEKLIENGISRVILGTIAMEDEGLLKKAIECY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I VGID N Y ++ LD+ + ++ G I++ ++ Sbjct: 121 G-EKISVGIDCK----------NGYVYGRGWLAESKLNYLDFAKNMESLGVKSIIVTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G + + L K++++ ++ + ASGG +E+ E ++ D+ GA+ + ++ Sbjct: 170 KDGTLEGPNFDMLMKLKKLVNIDITASGGIRDIENIKE-LKNIDIYGAITGKAIYSGNLS 228 Query: 241 IGELKAY 247 + E Sbjct: 229 LKEAIDI 235 >UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria RepID=B4SDB6_PELPB Length = 256 Score = 205 bits (523), Expect = 9e-52, Method: Composition-based stats. Identities = 80/256 (31%), Positives = 131/256 (51%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M R+I LD++ ++KG+ +IG A RY ++G DEL++ D AS R Sbjct: 1 MRNIRLIARLDIKGPNLIKGIHLEGLRVIGSPNEYALRYYQQGVDELIYMDCVASLYDRN 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + A+ I +P V GGI+S+EDA +IL GADK+++N+ A+A+P LI ++ RF Sbjct: 61 HLGDIIRSAAKDIFVPMTVGGGIRSVEDATQILRSGADKVAVNTAAVANPKLINEISRRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ I+ + ++ T + + WV++ GAGE++L ++ Sbjct: 121 GSQCMVLSIEAKEVGKDRW-----EVYTDNGRERTGLDVIAWVKKGVAMGAGEVLLTSVD 175 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 ++G R G+D +K V +P+IASGG G E + D A + H Sbjct: 176 REGTRKGFDTALVKAVTAEVSIPVIASGGMGKPEDLVGVVSVGGADAVAMADILHYNRAG 235 Query: 241 IGELKAYLATQGVEIR 256 IGE++ G+ +R Sbjct: 236 IGEIRNVAKETGMGVR 251 >UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodopirellula baltica RepID=HIS4_RHOBA Length = 253 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 103/254 (40%), Gaps = 18/254 (7%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 I P +D+R G+ V+ Q D V AKR+ E GA L D+ A+ Sbjct: 11 RMEIWPAIDLRHGKPVRLRQGDYDQQTTFGDDPVEFAKRWQESGAKRLHLVDLDAARGDS 70 Query: 60 VV-DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 ++ V R+ E +P + GG++ +L+ G ++ + S AL DP + D Sbjct: 71 PDANRDAVQRIIEATGLPCQMGGGVRDEITIESLLNVGVTRLVVGSRALKDPDWFVEMCD 130 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR--GAGEIVL 176 ++ + + DA GK + + ++ +++ R IV Sbjct: 131 KYPGKLVAG-----IDARDGKVATQGWL------ETSDVSAFEFATKLRSRTENIAAIVY 179 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 + +DG+ G + E L ++ +PL+ASGG T + + + + A+ + Sbjct: 180 TDIAKDGMMQGPNFEGLAEMAAASDIPLVASGGVTTYDDIKQ-LVEMKMPAAIVGRSLYD 238 Query: 237 QIINIGELKAYLAT 250 ++ +GE+ Sbjct: 239 GVMELGEVVRLAGD 252 >UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillales RepID=HIS4_LACC3 Length = 238 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 53/246 (21%), Positives = 106/246 (43%), Gaps = 14/246 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII--GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+ +G+ V+ Q ++ D + A+R + G L D+ + R + Sbjct: 1 MKLYPAIDLLNGKSVRLTQGDYDQVSLTEDPLYQAQRLTDAGFAHLHLVDLDGARAQRPI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +++ ++R+ E + GGI++L L+ G D++ + S A++DP L+ + RFG Sbjct: 61 NRTVITRIREQTSAFIELGGGIRTLAAMEIYLTIGIDRLILGSAAVSDPDLVEQAIARFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 I VGIDT +Q + +Q+RG ++ + + Sbjct: 121 SNRIAVGIDTRA----------GKVATNGWLTTSQQTANALLTAMQQRGVTTFIVTDIAK 170 Query: 182 DGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ G + + L +++ +IASGG + + A + A+ + I Sbjct: 171 DGMMQGPNAQLLADLQQAMPQATIIASGGISLLADLHR-LQTAGIQAAIIGKAWQTGAIE 229 Query: 241 IGELKA 246 + LK Sbjct: 230 LAMLKQ 235 Score = 40.2 bits (93), Expect = 0.060, Method: Composition-based stats. Identities = 13/99 (13%), Positives = 34/99 (34%), Gaps = 1/99 (1%) Query: 157 WETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHF 216 + L Q + G + L ++ + + + ++RE + GG T+ Sbjct: 29 EDPLYQAQRLTDAGFAHLHLVDLDGARAQRPINRTVITRIREQTSAFIELGGGIRTLA-A 87 Query: 217 LEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEI 255 +E + +D + S + + A + + + Sbjct: 88 MEIYLTIGIDRLILGSAAVSDPDLVEQAIARFGSNRIAV 126 >UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomycetales RepID=D2Q1W2_9ACTO Length = 256 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 52/245 (21%), Positives = 109/245 (44%), Gaps = 17/245 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 ++P +DV DGQ V+ VQ + GD + A + E GA+ + D+ A+ GR ++ Sbjct: 18 LLPAVDVADGQAVRLVQGEAGSETSYGDPLAAATAWQEAGAEWIHLVDLDAAF-GRGSNR 76 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ V +D+ ++GGI+ E L+ GA +++I + AL DP R+ +G + Sbjct: 77 ELLADVTGRLDVQVELSGGIRDDESLEAALATGARRVNIGTAALEDPEWCDRVIQTYGDR 136 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + +G+D +T + + + ++ +++ G V+ + +DG Sbjct: 137 -VAIGLDVR----GRTLAARGWTKEGG-------DLYEVLERLERAGCERYVVTDVTKDG 184 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQIINI 241 + G +L+ + + P++ASGG +++ V+G + + + Sbjct: 185 MLQGPNLDLYRDLCARTAKPIVASGGVSSLDDLRALATLVPDGVEGVIVGKALYAGAFTL 244 Query: 242 GELKA 246 E Sbjct: 245 TEALE 249 >UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=142 Tax=cellular organisms RepID=HIS4_METNO Length = 253 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 53/261 (20%), Positives = 104/261 (39%), Gaps = 16/261 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 M + P +D+++G+ V+ VQ + D A +AE+G L D+ + Sbjct: 1 MTRVILFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFA 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G ++ + V + + IP + GGI+ + L+ G ++ I + A+ DP + A Sbjct: 61 GAPMNAAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFVREAA 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 F + V DA+ G+ V + + + + + G ++ Sbjct: 121 RLFPGRIAVG-----IDAKDGRVAVEGWAKT------STVTAEELGRRFEDAGVAALIYT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR--DADVDGALAASVFH 235 + +DGV G ++ + + +P+IASGG ++E A + GA+ + Sbjct: 170 DIARDGVLKGLNIPMTLALAQAVSIPVIASGGLASIEDVHRILEPDCALLAGAITGRALY 229 Query: 236 KQIINIGELKAYLATQGVEIR 256 I+ E A + R Sbjct: 230 DGRIDPREALAAIRRAEEARR 250 >UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Methanocaldococcus RepID=C9RH20_METVM Length = 237 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 119/247 (48%), Gaps = 16/247 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++D + V+ +Q + + D V +AK++ +GA+ L D+ A+ G Sbjct: 1 MIVIPAVDLKDKKCVQLIQGDPTKKHLELEDPVNVAKKWVHDGAEYLHIVDLDAAL-GCG 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + ++ E ++IP V GGI+SL A +++ G DKI + + A+ DPT + L Sbjct: 60 NNVDVIEKIVEEVNIPVEVGGGIRSLTIAKRLMDIGVDKIVVGTKAITDPTFLNELLSEI 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I++ ++ + ++ ++ +K+ G I+ ++ Sbjct: 120 EREKIILAVECKQ----------GKVAIKGWKETINKNPIEIAKKYEKK-VGGILFTNVD 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G+ +G + ++ + + VP+I SGG T+E + ++ VDG + S +K IIN Sbjct: 169 VEGMLSGIKTDIIETLVKNVRVPIIYSGGITTLEDIKK-LKEIGVDGVIIGSALYKGIIN 227 Query: 241 IGELKAY 247 + + Sbjct: 228 LKDALKI 234 >UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQP1_9RICK Length = 238 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 42/249 (16%), Positives = 107/249 (42%), Gaps = 14/249 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D++DG+ V+ + + + AK + ++G + L D+ + Sbjct: 1 MIIYPAIDLQDGKCVRLTKGDFEQQTVYSRSPIEQAKAFEDKGFEFLHVVDLDRTIHKEK 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + + + V GG+++ + +++ G + + + A+ DP L+ ++ ++ Sbjct: 61 SNLKTIKEIIQSTGLKVQVGGGLRTKDTVEEVIDLGVENAVMGTAAVNDPDLLIEISQKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I VG+D + T+ D+++ ++ I+ +N Sbjct: 121 -KNKISVGLDVRDKM----------IALKGWKDQTEISCFDFLETIKNLPLKSIIFTDIN 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG++ G +++ K+ E ++P+ ASGG +++ + G + + +I+ Sbjct: 170 KDGMKQGINIDDTLKMAESSNIPVTASGGVSSIDDIKLIKSKKKISGVVVGKAIYDGLID 229 Query: 241 IGELKAYLA 249 + EL + A Sbjct: 230 LNELVKFNA 238 >UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=HIS4_THERP Length = 244 Score = 204 bits (519), Expect = 2e-51, Method: Composition-based stats. Identities = 55/243 (22%), Positives = 105/243 (43%), Gaps = 15/243 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+R+G+ V+ + D + +A+R+A GA L D+ + G+ Sbjct: 1 MIVIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQP 60 Query: 61 VDKSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 V + RV + D+ V GG+++L+ ++L GA ++ I + AL P ++ R Sbjct: 61 VQHELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALAR 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FGV+ +VV +D+ + + V + V V G ++ + Sbjct: 121 FGVERVVVAVDSR----------DGWVATHGWETVQAIRVEEVVHRVVLLGVRRVLATDV 170 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG +LE + ++ V +IASGG G+ R V+ A+ ++ + Sbjct: 171 TRDGTLTRPNLELMGRLA-ALGVTVIASGGVGSRSDLEALARVPGVEAAIVGRALYEGRV 229 Query: 240 NIG 242 Sbjct: 230 RFE 232 Score = 47.9 bits (113), Expect = 3e-04, Method: Composition-based stats. Identities = 17/106 (16%), Positives = 38/106 (35%), Gaps = 2/106 (1%) Query: 142 VNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVC- 200 V + GD +R V + ++ Q GA + + ++ + E +++V Sbjct: 15 VRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPVQHELIERVIRAVP 74 Query: 201 HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKA 246 V + GG T+ +E + + ++ + E A Sbjct: 75 DVAVQVGGGVRTL-DAVERLLVGGAARVVIGTAALERPDMLREALA 119 >UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Faecalibacterium prausnitzii M21/2 RepID=A8S9L9_9FIRM Length = 239 Score = 204 bits (519), Expect = 2e-51, Method: Composition-based stats. Identities = 53/251 (21%), Positives = 100/251 (39%), Gaps = 16/251 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++ P +D+R GQVV+ Q D A+ + GA L D+ + DG + Sbjct: 1 MQLFPAIDLRGGQVVRLTQGDYDRMTVYGQDPCAQARSFVAAGAKNLHVVDLDGAKDGTL 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ +A+ + V GGI++ E K LS G + + S A+ D R+ ++ Sbjct: 61 SNYDTIAALAKQGGLYIEVGGGIRTEERIEKYLSLGVGRCILGSVAVTDFAFTARMLQKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I VG+D + Y V+ + + + + + G I+ + Sbjct: 121 GDK-IAVGVDAK----------DGYVAIHGWKEVSAEPGVAFCKRLAEAGCTAIIYTDIA 169 Query: 181 QDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG G +L +++ EV V ASGG + LE + A+ + + Sbjct: 170 CDGAMQGTNLSLYRQLAAEVPGVAFTASGGISSEAELLE-LQQMGTAAAILGKSLYTGAL 228 Query: 240 NIGELKAYLAT 250 ++ + Sbjct: 229 DLARCVQLVQD 239 >UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Lactobacillus rhamnosus RepID=C7TCJ1_LACRG Length = 249 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 104/246 (42%), Gaps = 14/246 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII--GDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+ GQ V+ Q ++ D + K G L D+ + + + Sbjct: 1 MQLYPAIDLLAGQSVRLTQGDYRQVSLTADPLTQVKNLTATGLKHLHLVDLDGARSQQPI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +++ +S + + + GGI++L L+ G D++ + S A+ +P L+T+ +FG Sbjct: 61 NQAVISTIRQHTPAFIELGGGIRTLAIMDHYLNAGIDRLILGSVAVTNPELVTQAVQKFG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 I VGID + + +Q + +RG ++ + + Sbjct: 121 ADKIAVGIDARA----------GKVATDGWLTTSTQSPTHLMQAMVRRGVTTFIVTDIGR 170 Query: 182 DGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG+ G ++ L + + V +V ++ASGG T+ A + A + A+ + Sbjct: 171 DGMMKGPNVALLAMLHQTVPNVNIVASGGVHTLADL-TALQTAGIQAAVIGKAWQTGSFP 229 Query: 241 IGELKA 246 + +LK Sbjct: 230 LNKLKE 235 >UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Caulobacter RepID=HIS4_CAUSK Length = 241 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 110/252 (43%), Gaps = 16/252 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + P +D++DGQ V+ + + A+R+ +G L D+ + +G+ Sbjct: 1 MILYPAIDLKDGQCVRLLHGDMEKATVFNNSPADQAERFVRDGFSWLHVVDLNGAIEGKS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + V + E I IP + GGI++LE + G ++ + + A+ DP L+ + A + Sbjct: 61 VNTAAVQSILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPDLVRKAARLW 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q V D GK V+ +TG ++ + + + + G +++ ++ Sbjct: 121 PEQIAVA-----VDVRDGKVAVDGWTG------LSDLDAITLGKRFEDVGVAALIVTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD--GALAASVFHKQI 238 +DG G ++E + ++ + +P+IASGG ++ V+ GA+ + Sbjct: 170 RDGALTGVNVEGVGELADAVSIPVIASGGVASVADIERLKARPGVEIAGAILGRSLYAGT 229 Query: 239 INIGELKAYLAT 250 I E A Sbjct: 230 IRPAEALTIAAA 241 >UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Prochlorococcus marinus str. NATL1A RepID=A2C1S3_PROM1 Length = 248 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 71/247 (28%), Positives = 130/247 (52%), Gaps = 6/247 (2%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 RII LDV++ V+KG+ +GD LA Y ++G +E+VF D AS R Sbjct: 1 MRIIGRLDVKNNHVIKGIHLEGLRKVGDPQELAVEYYKQGIEEIVFMDAVASLYNRNNLF 60 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + E + +P + GG++SL+D +K L+ GADK+ IN+ + L +A ++G Q Sbjct: 61 HIIQKACEKVFVPIALGGGLRSLDDVSKALNAGADKVVINTALVNRIDLAKEIAQKYGSQ 120 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 C+V I+ + ++ + +V+ + T+ +DW ++++ G GEI+L ++Q+G Sbjct: 121 CLVGSIEAKRENDSWRVYVD------NGREPTKHNVVDWAIKLKEAGVGEILLTSIDQEG 174 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 G+D+E +K++ E P+IASGG G +H + + + A H + + Sbjct: 175 TSKGFDIELIKQINESIRCPIIASGGYGNKKHLADLLKIVEPSAIAIAGSLHYKKDTVSS 234 Query: 244 LKAYLAT 250 +K + + Sbjct: 235 IKQEINS 241 >UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=16 Tax=Campylobacter RepID=HIS4_CAMJD Length = 244 Score = 203 bits (517), Expect = 4e-51, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 105/251 (41%), Gaps = 13/251 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +IIP LD+ DG+VV+ V+ + + K Y + GA EL D+T + D Sbjct: 3 QIIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKR 62 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + ++A+ + + V GGI+S E+ +L G ++ I S A+ D TL + +FG Sbjct: 63 QLVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFG 122 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + IV+ +DT + + + + ++ + +G I+ +++ Sbjct: 123 SEAIVLALDTILKED-------YVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISK 175 Query: 182 DGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG G ++ K + E + + ASGG +++ G + + + Sbjct: 176 DGTMQGVNVRLYKLIHEIFPKICIQASGGVASLKDLENL--KGICSGVIVGKALLDGVFS 233 Query: 241 IGELKAYLATQ 251 + E L Sbjct: 234 VEEGIRCLQNA 244 >UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillus RepID=HIS4_LACPL Length = 241 Score = 202 bits (515), Expect = 7e-51, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 107/247 (43%), Gaps = 16/247 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDG 58 + I P +D+R GQ V+ Q + I D V A++ G +L D+ + G Sbjct: 1 MQM-IFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSG 59 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R + + ++ + + + GGI++ E A + L G D++ + S AL DP L+ RL Sbjct: 60 RPENFATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLS 119 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG + IV+G+D N Y + +Q + ++ + GA ++ Sbjct: 120 EFGGERIVIGLD----------GTNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTD 169 Query: 179 MNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + +DG G +L +++ +V LIASGG + + + + + + Sbjct: 170 VARDGTMQGPNLALYQELQAQVPTANLIASGGVRNLTDV-QVLQASGFKDVIIGKALAEG 228 Query: 238 IINIGEL 244 + + EL Sbjct: 229 GVTLAEL 235 >UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=12 Tax=Bacteria RepID=HIS4_BRAHW Length = 238 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 114/250 (45%), Gaps = 15/250 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+++G+VV+ V+ D + + + E G+ L D+ +SDG Sbjct: 1 MYILPAIDLKNGEVVRLVEGNYDNKTTYFKDPLEVLDFFIESGSSYLHVVDLDGASDGET 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + +V + D+ V GGI++ + K L G + + + A+ + + +++ Sbjct: 61 INFKTIEKVIKKCDLFVEVGGGIRNEDTIKKYLDIGVKRTILGTAAVENIDFTNNMINKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I V ID+ + + + +++++ ++ G I+ ++ Sbjct: 121 -KEHIAVSIDSRDRM----------IAVKGWKEINKQDSVEFCMKLDSMGIDTIIYTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G +L+ K++RE +IASGG T E + RD ++GA+ ++ I+ Sbjct: 170 KDGKLSGTNLDIYKELREKISCNIIASGGV-TFEDEIIKLRDMKINGAIVGKAIYEGKID 228 Query: 241 IGELKAYLAT 250 + ++ Sbjct: 229 LKKIIEIAKQ 238 >UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZT22_9SPHI Length = 239 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 51/239 (21%), Positives = 98/239 (41%), Gaps = 15/239 (6%) Query: 14 DGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVA 70 +GQ V+ Q D + +A++YA+EG L D+ + G + V ++A Sbjct: 12 NGQCVRLTQGDYSQKRVYDKDPIEMAQKYADEGFQRLHVVDLDGAKSGAPKHLALVEQMA 71 Query: 71 EVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGID 130 ++ GGIK+ E +L GA +I S A+ P + FG I++ D Sbjct: 72 AKTNLTIDYGGGIKTTEQVQAVLDAGAAMANIGSLAVKQPEVFKGWLQTFGSDKILLASD 131 Query: 131 TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDL 190 + + ++ D++ + G + +++DG+ G L Sbjct: 132 VKGEK----------IAINAWQDESEVSIYDFIADFIPSGLTQFFCTDVSKDGLLQGVAL 181 Query: 191 EQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYL 248 E K++ + + +IASGG +M+ + +DG + ++ I + ELK + Sbjct: 182 ELYCKLKQKFPTMTIIASGGVASMQDIED-LNKEGIDGVIVGKAIYENRIALEELKQFA 239 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 56/250 (22%), Positives = 103/250 (41%), Gaps = 15/250 (6%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D++DG+ V+ + I D V AK+Y L D+ + G+ V+ Sbjct: 2 IFPAIDLQDGRSVRLYKGDFAQETVINPDPVDQAKQYEAAKVGALHLVDLDGAKAGKPVN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V V + GGI+ E LS G D++ + S AL +P L ++ +G Sbjct: 62 VDIVKAVRAAFTGILEIGGGIRDKEAVDLYLSLGVDRVILGSVALKNPKLTKQVIAEYGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+G+D N E + D + + + GA ++ +++D Sbjct: 122 EHIVIGVDGK----------NGKVAAEGWLDQSDVPMTDLIGAMIEGGAKYFIVTDVDRD 171 Query: 183 GVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + E L + +E ++ASGG +E ++ V ++ ++ I + Sbjct: 172 GTMQGANEELLGNLQKEFPTARIVASGGVRNLEDI-KSLEQKGVMDSIVGKALYEGTITL 230 Query: 242 GELKAYLATQ 251 E+ Y + Sbjct: 231 EEIGEYNQQK 240 >UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=B4W8G6_9CAUL Length = 243 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 101/250 (40%), Gaps = 11/250 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D++DG V+ + + +A EGA+ + D+ + G Sbjct: 1 MLIYPAIDLKDGVCVRLMHGKFDQVTRYDEQPATRLSAFAAEGAEWIHVVDLDGAEAGEA 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V + + + + ID+ GG++S D AK+L G ++ + S A+ P + F Sbjct: 61 VQHALIGELTKAIDVKIQSGGGVRSANDVAKLLDTGVSRVVVGSLAVTQPNDVAAWLKGF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I + D + + + T+ + + + K +++ + Sbjct: 121 GAEHITLAFDVKIEDGVPVPALKGW------TQSSGVDLWTALDRYPKGLFKHLLVTDVG 174 Query: 181 QDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G +LE L ++ R + L ASGG +++ A + +GA+ ++ Sbjct: 175 RDGAMTGPNLELLAEIRRRRPDLVLQASGGVSSLDDI-AAVKSLGCNGAIVGRALYENRF 233 Query: 240 NIGELKAYLA 249 + + A A Sbjct: 234 TLPDAIATAA 243 >UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase subunit hisF3 n=18 Tax=cellular organisms RepID=HIS63_VIBVY Length = 260 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 86/237 (36%), Positives = 136/237 (57%), Gaps = 4/237 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L +R+ +VK V+F+ + +GD + K + E+ ADEL DI AS G Sbjct: 6 MLRSRVIPVLLMREKGLVKTVKFKEGKYVGDPLNAVKIFNEQEADELTLLDIDASRLGHE 65 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + R+A +P C GGIK++E A +IL G +K+S++S +P +IT+LA+R Sbjct: 66 PDYVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERV 125 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q IVV +D K+ G + ++ +T+++V+++Q GAGEIVLN ++ Sbjct: 126 GRQSIVVCLDVKKRLFGSKFDCFTINGTKKQS----VDTIEFVKQIQTLGAGEIVLNFID 181 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 DGV GYDL+ + K + + VPL GGAG ++ + + + GA A S+F + Sbjct: 182 NDGVMKGYDLDAVSKFKALVKVPLTVVGGAGCVDDIAKLVQQEKLVGAAAGSLFVFK 238 >UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_YEAST Length = 552 Score = 200 bits (508), Expect = 5e-50, Method: Composition-based stats. Identities = 89/314 (28%), Positives = 141/314 (44%), Gaps = 58/314 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQ--------FRNHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q + +G V LA++Y ++GADE+ Sbjct: 236 LTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVT 295 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKS-----------LEDAAKILS 94 F +IT+ D + D + + A+ + +P V GGIK LE A+ Sbjct: 296 FLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFR 355 Query: 95 FGADKISINSPALADPTL-------------ITRLADRFGVQCIVVGIDTWYD------- 134 GADK+SI + A+ I ++ +G Q +V+ +D Sbjct: 356 SGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQAD 415 Query: 135 -----------AETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 G+ + + + + + GAGEI+LN +++DG Sbjct: 416 TKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDG 475 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +GYDLE ++ V++ +P+IAS GAG EHF EAF D L A +FH+ + + Sbjct: 476 SNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVND 535 Query: 244 LKAYLATQGVEIRI 257 +K YL G+++R+ Sbjct: 536 VKEYLLEHGLKVRM 549 >UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Deinococci RepID=C1CY68_DEIDV Length = 251 Score = 200 bits (508), Expect = 5e-50, Method: Composition-based stats. Identities = 47/244 (19%), Positives = 101/244 (41%), Gaps = 15/244 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIPC+D++ G+ V+ + + A+ + E GA + D+ A+ GR + Sbjct: 19 IIPCVDIQSGRAVRLYEGDPERETVYFDSPLDAARHWVERGAGLVHLVDLDAA-TGRGEN 77 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + ++ + +P V GGI+ E A +L G ++ I + A+ +P L+ L G Sbjct: 78 REVIRQITSELGVPVEVGGGIRDREAAEDLLRAGVHRVVIGTAAVRNPQLVADLIAAHGP 137 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV +D + + + + G ++ + +D Sbjct: 138 ERVVVSLDAR----------GLEVATHGWAQGSGVNVAELTPGLADAGLELLIFTDVTRD 187 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G + E +++VR++ LI GG M+ ++ ++GA+ ++ + Sbjct: 188 GTLKGLNRELMRQVRQLWINTLIVGGGVANMDDV-RLLQEERIEGAIVGRAIYEGTLAYP 246 Query: 243 ELKA 246 + Sbjct: 247 VILE 250 >UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H029_9FIRM Length = 250 Score = 200 bits (508), Expect = 5e-50, Method: Composition-based stats. Identities = 100/254 (39%), Positives = 151/254 (59%), Gaps = 6/254 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + K I+PC+D+R G+VVKG++F + + D V LAK Y GAD LVFYDI AS + + + Sbjct: 1 MKKLIMPCMDIRHGKVVKGIKFEGVKDVADPVELAKYYDATGADILVFYDIAASVEDKQI 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V V D+P GG+K++ED I+ GAD +SIN+ A+ +P L+ A++ G Sbjct: 61 YEGLFKSVRAVSDLPLVAGGGLKTIEDVDNIIKLGADMVSINTGAIDNPDLLNEAAEKIG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +++ +D K + + + T + L+W+ E RGAG +VLN ++ Sbjct: 121 SENVILSVDAK------KVNGEYHVFRNAGMMDTGLDALEWISEGYDRGAGILVLNSIDT 174 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DGV+ GYD+E LK EV ++ASGGAG M+ F EA V+ ALAASVFH + I I Sbjct: 175 DGVKAGYDIEMLKAAGEVTDAKIVASGGAGKMQDFKEALMLPKVEVALAASVFHYKEIVI 234 Query: 242 GELKAYLATQGVEI 255 +LK YL +G+++ Sbjct: 235 DDLKEYLRKEGIDV 248 >UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB3_9BACT Length = 239 Score = 199 bits (507), Expect = 6e-50, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 102/249 (40%), Gaps = 18/249 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 M I P +D+ +VV+ + D V A +AE GA + D+ + Sbjct: 1 MKKIEIYPAIDLYSRKVVRLTGGDFEKIKEYGDDPVETALSFAEAGARWIHLIDLEGAEK 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G V + +VA +P GG+++ ED A LS GA ++ + S L Sbjct: 61 GSPVHLKELEKVAASTGLPVQYGGGLRTEEDVALALSSGAKRVYLGSLLFKGSP--RTLW 118 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 RFG IV +D N T VTQ + + E+ + G ++ Sbjct: 119 KRFGNS-IVPSVDVK----------NGTVALSGWTEVTQLPPEEAITELLRIGYSTFLVT 167 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +++DG +G DL+ +++++ ++A+GG + + + V GA+ ++ Sbjct: 168 SVSRDGTASGPDLKLYERLKK-TDGRILAAGGIRDKKDLAD-LAEIGVSGAVLGKSIYEG 225 Query: 238 IINIGELKA 246 +++ E Sbjct: 226 TVDLREAVE 234 Score = 51.4 bits (122), Expect = 3e-05, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 35/116 (30%), Gaps = 3/116 (2%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSW 65 I+P +DV++G V + G + ++ D Sbjct: 125 IVPSVDVKNGTV--ALSGWTEVTQLPPEEAITELLRIGYSTFLVTSVSRDGTASGPDLKL 182 Query: 66 VSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 R+ + D AGGI+ +D A + G + + + FG Sbjct: 183 YERLKK-TDGRILAAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAVEEFG 237 >UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=HIS42_PHOLL Length = 258 Score = 199 bits (507), Expect = 6e-50, Method: Composition-based stats. Identities = 47/256 (18%), Positives = 103/256 (40%), Gaps = 20/256 (7%) Query: 3 AKRIIPCLDVRDGQV------VKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDIT 53 I P +D+ DG ++ + + +G +A + GA + D+ Sbjct: 6 TFEIFPSVDIVDGIAMTSNSAIRLTRGESSTLRRPLGTPAEVALAWQNAGAKWIHVVDLD 65 Query: 54 ASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 A+ GR + ++ V +DI V GGI+ K+L+ G ++++ + AL +P Sbjct: 66 AA-SGRGSNSHLIADVLAAVDINVQVCGGIRDETILRKVLATGCQRVNLGTAALENPDWC 124 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 + +G + I + +D +E + + + + D ++ + K+G Sbjct: 125 AQAIAEYGDK-IAIALDVKSTSEGYQLATHGWNVSKG-------NLWDLLERLDKQGCQR 176 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAA 231 V+ + + G+ + + L++V P+IA GG +++ V+GA+ Sbjct: 177 YVVTDVERGGMMSSPNFTLLQEVCAKTSSPVIAGGGVSSLDDLRALADLSTIGVEGAILG 236 Query: 232 SVFHKQIINIGELKAY 247 H + + + A Sbjct: 237 QALHIGKVPLEDALAA 252 >UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Legionella pneumophila RepID=HIS4_LEGPL Length = 239 Score = 199 bits (507), Expect = 6e-50, Method: Composition-based stats. Identities = 48/246 (19%), Positives = 102/246 (41%), Gaps = 12/246 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGD---IVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++ G+ V+ Q R ++ + A +A+ GA L D+ + G++ Sbjct: 1 MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKM 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + I GGI+S+E A + + G ++ I S A+ +P L ++ ++ Sbjct: 61 QQLELICSM-QKTGIAIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKI 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + IV+ +D D + +N + + + V + G I+ + Sbjct: 120 KPENIVLALDVRVDTKVPLLAINGW------QNNSTSSLWEVVSYYENHGIKHILCTDIA 173 Query: 181 QDGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG+ NG + + ++ E + ASGG M+ + + + ++ + Sbjct: 174 CDGMMNGPNFDLYQQAVEYFPQIAWQASGGIRHMQDI-TTLGSLGISAVILGLMLYQDNV 232 Query: 240 NIGELK 245 N EL Sbjct: 233 NFEELL 238 >UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G189_ABIDE Length = 238 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 48/250 (19%), Positives = 113/250 (45%), Gaps = 15/250 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSD 57 M A I P +D+ +G+VV+ ++ ++ ++V A G + L D+ + + Sbjct: 1 MAAMIIFPAIDIYEGKVVRLLKGDYNKMTIYSENVVDKACEIEAAGGEWLHLVDLEGAKE 60 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G + ++V + + + + GGI++ K ++ G ++I + + A D + ++ Sbjct: 61 GNTPNFTYVEEICKKTGLKVEIGGGIRTEATIEKYINAGVNRIILGTKAATDKEFLNKMT 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 D++ + I VGID + + VT D+V E+++ G I++ Sbjct: 121 DKY-REKIAVGIDVKDEK----------VAIKGWLEVTDKTIFDFVTELKEIGIKNIIVT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + +DG +G ++ +K+ + + + ASGG T++ + ++ + GA+ + Sbjct: 170 DIAKDGAMSGINVSFYEKLSKFTDMDITASGGVTTLDDLIR-LKNTGIYGAILGKAMYTG 228 Query: 238 IINIGELKAY 247 +++ E Sbjct: 229 NVDLREALKI 238 >UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C5E2I9_LACTC Length = 550 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 91/314 (28%), Positives = 139/314 (44%), Gaps = 58/314 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQ--------FRNHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q N +G V LA++Y E+GADE+ Sbjct: 234 LTRRIIACLDVRTNDQGDLVVTKGDQYDVREKQEGGNVRNLGKPVELAQKYYEQGADEVT 293 Query: 49 FYDITASSDGRVVD---KSWVSRVAEVIDIPFCVAGGIKSLED-----------AAKILS 94 F +IT+ D + D + + A+ + +P V GGIK + D AA + Sbjct: 294 FLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTHIPALQVAALYFA 353 Query: 95 FGADKISINSPALADPTL-------------ITRLADRFGVQCIVVGIDTWYDAETGKYH 141 GADK+SI S A+ I ++ +G Q +V+ +D G Sbjct: 354 SGADKVSIGSDAVYAAEKYYELGERGDGASPIETISKSYGAQAVVISVDPKRVYVDGPES 413 Query: 142 VN--------------QYTG----DESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 V + + + + + GAGE++LN +++DG Sbjct: 414 VKHKTFETKFPNEKGQTWCWYQCTIKGGRESRDMGVWELTRACEALGAGEVLLNCIDKDG 473 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +GYDLE + +E +P+IAS GAG +HF EAF D L A +FH+ + + Sbjct: 474 SNSGYDLELINHAKEAVKIPVIASSGAGEPKHFKEAFESTGADACLGAGMFHRGEYTVND 533 Query: 244 LKAYLATQGVEIRI 257 +K YL G ++R+ Sbjct: 534 VKQYLLDSGFKVRM 547 >UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=1 Tax=Silicibacter lacuscaerulensis ITI-1157 RepID=D0CY30_9RHOB Length = 282 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 104/255 (40%), Gaps = 15/255 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRV 60 R+ P +++++G+ V + R E + D V A+ +A GA+ + D + +GR Sbjct: 36 MRVYPTMELQNGRCVTLDKGRLDEPMIWHVDPVETAQGWAAAGAEWMHLTDFD-AIEGRD 94 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V ++ ++P +AGG +S E + + GA +I I + A DP L LA + Sbjct: 95 TNSALVEQIIRSAELPVQLAGGFRSREQVERWIDKGAGRIVIGTLAARDPHLFKELAKLY 154 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q IV+ +D Y + + + +++ I++ ++ Sbjct: 155 PDQ-IVLAVDV----------WQGYVMTDGWRTQSAFSPEAFIEAFADAPLAAILVTDID 203 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 D V L + + P+IASG + + ++ G L ++ ++ Sbjct: 204 SDMVDVEAQLGLISGLAAHSRTPVIASGVVRSSDDISRLAYIPNISGVLVGRALFRKTVD 263 Query: 241 IGELKAYLATQGVEI 255 + E A T + Sbjct: 264 LSEALAVARTAHEPV 278 >UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Roseburia RepID=C7GBG4_9FIRM Length = 252 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 92/258 (35%), Positives = 133/258 (51%), Gaps = 6/258 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L + +VKGV F + + ++P K Y DEL+ DI A+++ R Sbjct: 1 MLKVRVIPTLLYKSVGLVKGVGFNSWRRVDTVLPAIKVYNMREVDELILLDIEATNEKRD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + + +PFCV GGI ++ +L GADK++INS A + +LIT A F Sbjct: 61 PDYDEIRDFSRECFVPFCVGGGICHIDQIKNLLRAGADKVAINSAAYDNLSLITEGAKLF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCIV ID K + + + T W DW+ +V + GAGEI+L + Sbjct: 121 GSQCIVASIDCR------KIDGEYHCFSHNGSVDTGWLLQDWIIKVVEAGAGEILLTSVE 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG GYD+E +K + +VP+IASGGAG EH +A ++ AAS++H Sbjct: 175 LDGTMEGYDVEMIKIATSLVNVPVIASGGAGNYEHMRKAVQEGGASAVAAASIYHFTEQT 234 Query: 241 IGELKAYLATQGVEIRIC 258 E K YL GV +R+ Sbjct: 235 PKEAKEYLGEHGVAVRMI 252 >UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Planctomycetaceae RepID=A6C5Q1_9PLAN Length = 246 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 104/255 (40%), Gaps = 21/255 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+R G+ V+ Q D +A+R+A+ GA L D+ + G+ Sbjct: 1 MEILPAIDIRGGKCVRLRQGDYGQETVFGDDPTEMARRWADGGAQRLHLVDLDGAKAGQP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKIL-SFGADKISINSPALADPTLITRLADR 119 V+ V ++ E + +P + GGI+ +L G D++ + + AL DP ++ R Sbjct: 61 VNHEVVRKIVEAVSVPCQMGGGIRDEASIQLMLDEVGIDRVIVGTQALKDPQWFKQMVQR 120 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 + + + +G+D + E V++ +D +E ++ + Sbjct: 121 YPNR-LALGLDAR----------DSKVATEGWLDVSETSAIDLAKEYVGVELAAVIYTNI 169 Query: 180 NQDGVRNGYDLEQLKKVREVC--HVPLIASGGAGTMEHFLEAFR----DADVDGALAASV 233 DG+ G D ++ + + +P+IASGG T++ + GA+ Sbjct: 170 ANDGMMQGVDEGTIQDMIALAELGLPVIASGGVTTLKDVSRLAEVSRTQPKLVGAIIGRA 229 Query: 234 FHKQIINIGELKAYL 248 ++ I + Sbjct: 230 LYEGTIEVPAAIEAA 244 >UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=21 Tax=Bacteria RepID=HIS4_XYLF2 Length = 269 Score = 197 bits (502), Expect = 3e-49, Method: Composition-based stats. Identities = 54/250 (21%), Positives = 103/250 (41%), Gaps = 10/250 (4%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 + + P LD+R+G VV+ Q ++P A+ +A+ GA + D+ A+ G Sbjct: 1 MNFIVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + ++ + GG++S +D A+IL GA ++ I S A+ T + Sbjct: 61 GYTLAPLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQ 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 FG + I V +DT DA T V + Q+ G ++ Sbjct: 121 AFGPERITVALDTRQDAGGVW-----RLPVHGWTEVAEATLEALAQQYAAAGLRHLLCTD 175 Query: 179 MNQDGVRNGYDLEQLKKVREVCH-VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + +DG+ +G +++ +R + V + SGGA + + A + A G + + Sbjct: 176 IARDGMLSGPNMDVYAYLRALVPAVQIQVSGGARDVADVVAA-KMAGCAGIVLGKALLEG 234 Query: 238 IINIGELKAY 247 + + E + Sbjct: 235 RLALKEAVQH 244 >UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sibiricum 255-15 RepID=B1YL10_EXIS2 Length = 234 Score = 197 bits (501), Expect = 3e-49, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 109/247 (44%), Gaps = 15/247 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 ++ P +D+ GQ V+ Q GD + +A+R+ E+GA + D+ + G + Sbjct: 1 MQLYPAIDLMSGQAVRLKQGDFQQQTFFGDALTIARRFKEDGATAIHLIDLDGAKAGEPL 60 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 S ++ + + + GG++++E + G D+I I + AL D L+ ++ +R G Sbjct: 61 HLSLIADIKKETGLFVEAGGGVRNIETVEAYVGAGIDRILIGTVALEDEALLEQMIERAG 120 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + + V +D + + W ++ + ++G + +++ Sbjct: 121 DK-LAVALDAK----------DGIVQTRGWLEASDWTLERAIEHLIQKGIKTFLYTDISR 169 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG+ G D++ L + + V LIASGG T+E ++ +DGA+ +++ Sbjct: 170 DGMMQGPDVDGL-DLLKRDGVELIASGGVTTVEDVAR-LKEIGMDGAVIGRALLDGSLSL 227 Query: 242 GELKAYL 248 E+ Sbjct: 228 KEVLRVC 234 Score = 44.1 bits (103), Expect = 0.004, Method: Composition-based stats. Identities = 16/94 (17%), Positives = 38/94 (40%), Gaps = 1/94 (1%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL 217 + L + ++ GA I L ++ L + +++ + + A GG +E + Sbjct: 30 DALTIARRFKEDGATAIHLIDLDGAKAGEPLHLSLIADIKKETGLFVEAGGGVRNIE-TV 88 Query: 218 EAFRDADVDGALAASVFHKQIINIGELKAYLATQ 251 EA+ A +D L +V + + ++ + Sbjct: 89 EAYVGAGIDRILIGTVALEDEALLEQMIERAGDK 122 >UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alteromonadales RepID=HIS4_PSEHT Length = 242 Score = 197 bits (501), Expect = 3e-49, Method: Composition-based stats. Identities = 48/245 (19%), Positives = 99/245 (40%), Gaps = 11/245 (4%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGDIVPL---AKRYAEEGADELVFYDITASSDGRVVD 62 IIP LDV Q+V+ Q + + L K YA+ GA +L D+ + D Sbjct: 2 IIPALDVLQNQIVRLYQGKYETVQFYPFELGARLKEYADSGAGKLHLVDLEGARDPSKKQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +++P+ V GGI+ +D + L GA+++ I S A+ + ++FG Sbjct: 62 WQHIQAATKALNVPYQVGGGIRCEQDVSDWLKAGANQVVIGSMAVEKREQVKAWIEQFGA 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + V+ +D A +++ L+ V G + + +++D Sbjct: 122 EHFVIALDVNKTATGWAPA------THGWLTESEFGLLELVDFYANLGVIDFLCTDISKD 175 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + + + + + ASGG +++ + ++ + G + ++ Sbjct: 176 GTMTGPSFALYEDLIKHNSTIKVQASGGVSSLDDIKK-LKELGIGGIILGKSLLDGAFSV 234 Query: 242 GELKA 246 E A Sbjct: 235 EEALA 239 >UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Coriobacteriaceae RepID=C8WPG6_EGGLE Length = 257 Score = 197 bits (500), Expect = 4e-49, Method: Composition-based stats. Identities = 45/249 (18%), Positives = 100/249 (40%), Gaps = 15/249 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++P +D+ G+ V+ + D A+ + E+GA L D+ + G Sbjct: 1 MYLLPAIDILGGKAVRLAKGDYDRVTVYHDDPAAQAQLFEEQGATWLHVVDLDGARSGIP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V R+ + V GG++SL+ A++ G ++ + + +ADP ++ Sbjct: 61 ENIAIVERIMRKTLLKVEVGGGVRSLDTIARLADAGVSRVVLGTSLVADPDFAEAAIAQY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G DA+ G+ V + + +++ G +V + Sbjct: 121 GKLLCAG-----IDAKGGEVAVAGW------REGAGVAAEELARDMSALGFRHLVYTDIA 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD-VDGALAASVFHKQII 239 +DG++ G + ++ E P+IASGG ++ + A ++G +A ++ + Sbjct: 170 RDGMQTGIEAAAYVRMAEAFGHPVIASGGVAGVDDIVRLGEVAGSIEGVIAGRAVYEGAL 229 Query: 240 NIGELKAYL 248 ++ E Sbjct: 230 SVQEGVRAC 238 >UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Deinococcus RepID=HIS4_DEIGD Length = 243 Score = 197 bits (500), Expect = 5e-49, Method: Composition-based stats. Identities = 47/241 (19%), Positives = 100/241 (41%), Gaps = 15/241 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDG 58 L IIPC+D++ G+ V+ + + A+ +A GA + D+ A+ G Sbjct: 8 LQPLIIPCVDIQSGRAVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDAA-TG 66 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 R +++ ++++ + +P V GGI+ A +L G ++ I + A+ +P L+ L Sbjct: 67 RGENRAVITQITAELGVPVEVGGGIRDRAAAEALLDAGVGRVVIGTAAVKNPALVRELIA 126 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G +VV +D + + + + G ++ Sbjct: 127 AHGPSRVVVSLDAR----------GLDVAIHGWAEGSGVSVAELAPLLAEAGLETLIFTD 176 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 + +DG G D + +++VR++ LI GG T++ + + GA+ ++ Sbjct: 177 VTRDGTLRGLDRDLMRQVRQLWSNTLIVGGGVATLDDV-RLLAEEGIQGAIVGRAIYEGT 235 Query: 239 I 239 + Sbjct: 236 L 236 Score = 47.2 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 45/126 (35%), Gaps = 11/126 (8%) Query: 141 HVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVC 200 V Y GD R V L+ + GAG + L ++ G + + ++ Sbjct: 23 AVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDA-ATGRGENRAVITQITAEL 81 Query: 201 HVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAY---------LATQ 251 VP+ GG EA DA V + + K + EL A L + Sbjct: 82 GVPVEVGGGIRDRA-AAEALLDAGVGRVVIGTAAVKNPALVRELIAAHGPSRVVVSLDAR 140 Query: 252 GVEIRI 257 G+++ I Sbjct: 141 GLDVAI 146 >UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Leptospira biflexa serovar Patoc RepID=HIS4_LEPBA Length = 247 Score = 196 bits (498), Expect = 7e-49, Method: Composition-based stats. Identities = 43/254 (16%), Positives = 108/254 (42%), Gaps = 16/254 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++P +D+ D + V+ +Q + + + E+GA + D+ A+ G+ Sbjct: 1 MLVLPAIDLLDNEAVRLLQGDYSKKTVYSSSPEKMIQVFEEQGATLIHIVDLNAAKTGKS 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + ++ E + + GGI+++++ G ++ + + A+ +P ++ + F Sbjct: 61 ENEKTIKKIKEKCTVDLELGGGIRTIDNMKFYDGLGVSRLILGTVAVEEPNVVEKAVSLF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G IV+G+D N Y + + D++ + G ++ + Sbjct: 121 GQDRIVIGVDAK----------NGYVRTKGWESNSGILYKDFLTTMYGMGIRHVIFTDIA 170 Query: 181 QDGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDAD--VDGALAASVFHKQ 237 +DG+ G + ++ E + L+ASGG + E +E + + + GA+ ++ Sbjct: 171 RDGMMEGPNTLAYAELLETFPDLQLVASGGVSSKEDLVELYDKTNGKLFGAITGKAIYEG 230 Query: 238 IINIGELKAYLATQ 251 +++ E L + Sbjct: 231 KLDLKESIRILNQK 244 >UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Zymomonas mobilis RepID=HIS4_ZYMMO Length = 250 Score = 195 bits (497), Expect = 1e-48, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 97/252 (38%), Gaps = 16/252 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 I P +D+++G VV+ + D A+++ E GA L D+ + G ++ Sbjct: 7 IFPAIDLKEGHVVRLSEGDMDRATIYDDDPAARARQFYEAGARYLHVVDLDGAFAGHAMN 66 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + V + + + GGI+ + LS G ++ I + A +P L+ A ++ Sbjct: 67 AAAVDAIVKAFPGTIELGGGIRDMNAIDGWLSRGISRVVIGTAAFENPDLVKEAAQKYPG 126 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 Q IVV +D + + ++ D + G ++ + +D Sbjct: 127 Q-IVVAVDAR----------DGMVTTKGWAEQSEISVTDMAERFADAGVVALLYTDVGRD 175 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDA--DVDGALAASVFHKQIIN 240 G++ G + E + +P+IASGG + R ++G + + ++ Sbjct: 176 GLKKGCNSEATLALAAATDIPVIASGGVKDIGDIELLARHTKDGIEGVICGRAIYDGSLD 235 Query: 241 IGELKAYLATQG 252 + A G Sbjct: 236 LKAALAIARQGG 247 >UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Leptospira RepID=HIS4_LEPBL Length = 241 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 45/251 (17%), Positives = 103/251 (41%), Gaps = 16/251 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+ D V+ + E + LA+ +A+ GA L D+ + + Sbjct: 1 MIIIPAIDLFDNCAVRLFKGNYKEKKIYSSEPWKLAEGFAKNGATLLHLVDLNGARNQLG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 +++ + ++ + + + GGI+ E A G D+ + + A+ DP L+ D + Sbjct: 61 INEDSILKIRKTTSLKVQLGGGIRDKEKLAYYDKIGIDRFILGTAAVTDPDLLKFALDNY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + +VV +D ++ + + D + + K G IV + Sbjct: 121 EKERVVVAVD----------AIDGIVKIAGWEKDSGVRYRDLMDRLAKAGIEHIVFTDIA 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE---AFRDADVDGALAASVFHKQ 237 QDG G +L+ +++ +IASGG +++ ++ + G + ++ Sbjct: 171 QDGTLAGPNLKAYQEILNSYPFQVIASGGISSLKDLMDLSSLKTKIPLYGVITGKALYEG 230 Query: 238 IINIGELKAYL 248 +++ + + + Sbjct: 231 KLDLAKAISSI 241 >UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=HIS4_BUCBP Length = 241 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 47/245 (19%), Positives = 96/245 (39%), Gaps = 10/245 (4%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ +G +V+ Q +I +A +Y +GA + D+ + Sbjct: 2 IIPSIDLIEGNIVRLYQGNYDTKTFYQNNIYDIALKYYNQGAKIVHLVDLDGALCPNNKQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 S + + + V GGI+S +D +L GA ++ I S A+ + T + + FG Sbjct: 62 TSLIKNLLNYFNFHIQVGGGIRSYKDVETLLLNGAKRVVIGSSAINNITEVEKWLLEFGY 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + IV+ +D + K V + ++ G ++ + +D Sbjct: 122 KSIVLALDVYVRNNGYKEVV-----INGWKNRSNVSLESVLERFSTLGIKYVLCTDVKKD 176 Query: 183 GVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 G G + K + ++ +V SGG GT+ + A + + + + + ++ Sbjct: 177 GTCLGPNFTLYKNISKLFKNVCFQLSGGIGTISDVISA-KKSGIKDIIIGRALLENKFSL 235 Query: 242 GELKA 246 E Sbjct: 236 LEAIR 240 >UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=117 Tax=Enterobacteriaceae RepID=HIS4_BLOFL Length = 251 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 44/256 (17%), Positives = 104/256 (40%), Gaps = 12/256 (4%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP LD+ +G V+ Q + + G+ + Y ++GA + D+ + + + Sbjct: 2 IIPALDIINGDAVRLYQGKYQSQSHYGNPYSILSTYVQQGATMIHLVDLDGARNPKNRQL 61 Query: 64 SWVSRV---AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 S + + A + + GGI+ D +L FG +++ + S A+ P + + F Sbjct: 62 SLIKELTHTAITSHLKIQIGGGIRHATDIKTLLKFGVNRVILGSIAITHPKKVKQWFTYF 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 +V+ +D + D++ + V + T + + ++ G ++ ++ Sbjct: 122 NPSSLVLALDIYIDSKNNRKVV-----IHGWQKETNIQLEEVIENYNSVGLKHVLCTDIS 176 Query: 181 QDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G ++ + + + + ASGG + L+ R + V+ + F ++ Sbjct: 177 KDGTLLGSNINLYQSICYKWPKISFQASGGVAKLTEILQ-LRSSGVNSIIIGRSFLEKKF 235 Query: 240 NIGELKAYLATQGVEI 255 + E + + Sbjct: 236 TLTEAISCWQNASSRV 251 >UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) n=8 Tax=Saccharomycetales RepID=C4R8P0_PICPG Length = 561 Score = 193 bits (492), Expect = 4e-48, Method: Composition-based stats. Identities = 88/313 (28%), Positives = 138/313 (44%), Gaps = 58/313 (18%) Query: 2 LAKRIIPCLDVR-----DGQVVKGVQFR--------NHEIIGDIVPLAKRYAEEGADELV 48 L +RII CLDVR D V KG Q+ + +G V +A++Y ++GADE+ Sbjct: 246 LTRRIIACLDVRTNDSGDLVVTKGDQYDVREKSESGDVRNLGKPVEMAEKYYQQGADEVT 305 Query: 49 FYDITASSDG---RVVDKSWVSRVAEVIDIPFCVAGGIKSLED-----------AAKILS 94 F +IT+ + + R AE + +P V GGIK + D A Sbjct: 306 FLNITSFRNSPIKDAPMLEVLKRAAETVFVPLTVGGGIKDVVDPDGTKVPALKVATLYFR 365 Query: 95 FGADKISINSPALADPTL-------------ITRLADRFGVQCIVVGIDTWY-------- 133 GADK+SI + A+ I ++ +GVQ +V+ +D Sbjct: 366 AGADKVSIGTDAVLAAEEFYRNNEKGTGLTPIETISASYGVQAVVISVDPKRFYVADPSK 425 Query: 134 ----------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 G+ + + V + +K GAGEI+ N +++DG Sbjct: 426 TPYKTIKTKFPGPNGENYCYYKVTSQGGRNVHDLGAWELCYACEKLGAGEILCNCIDKDG 485 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +GYDLE + ++ +P+IAS GAG HF E FR + D AL A +FH+ + E Sbjct: 486 SNSGYDLELIDYIKSATKLPVIASSGAGNPSHFEEVFRKTETDAALGAGMFHRGEYTVKE 545 Query: 244 LKAYLATQGVEIR 256 +K +L +G+ +R Sbjct: 546 VKDFLTKRGLLVR 558 >UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y7T0_9BACT Length = 237 Score = 193 bits (492), Expect = 4e-48, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 99/246 (40%), Gaps = 15/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+ GQ V+ + +A +A +GA +L D+ + +G Sbjct: 1 MLIYPAIDLYAGQAVRLQRGDYARMTVYSDRPETVAADFAAQGARQLHLIDLEGAKNGGT 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V + + V GGI+S++ L G D++ + + A R R+ Sbjct: 61 PNLETIVAVKKSSGLFCQVGGGIRSMDAIVAYLDAGVDRVILGTAAATQAHFAARAVARY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I VG+D + + + T + + ++ + +Q G ++ ++ Sbjct: 121 GAR-IAVGVDIK----------DGFAAVKGWTEKSPLKAFEFCRRMQSDGVSTLICTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G ++ K + + +IASGG +++ + GA+ + + I+ Sbjct: 170 RDGMMQGTNVALYKTLSTELKMRIIASGGVSSLDDVRR-LAALGLYGAIIGKACYTKAIS 228 Query: 241 IGELKA 246 I Sbjct: 229 IAAAIE 234 >UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVE8_9SPHI Length = 244 Score = 193 bits (491), Expect = 4e-48, Method: Composition-based stats. Identities = 47/252 (18%), Positives = 110/252 (43%), Gaps = 13/252 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP + + +G+ V+ + I + + +A+ + G L D+ + G Sbjct: 2 FEVIPSIWLINGKCVRLKRGDFATEEAISNNPLEIAQGFESIGIKRLHLVDLDGARRGEP 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + +A ++ GG+ + D K FGA ++I+S A P ++ + Sbjct: 62 KNYHILEAIAGYTNLHVDFTGGVTTDGDVIKSFEFGAKTVTISSAAANYPERFSQFILSY 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + I + DT + K + + + T+ + D ++ RG + + + Sbjct: 122 GREKINLAADT--NPADRKIKIRGWL------KKTEIDLYDHIEFFYDRGLKYLKCSDVT 173 Query: 181 QDGVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DGV G + E V++ ++ + ASGG ++E F E + V+ A+ +++ ++ Sbjct: 174 RDGVMVGPNFELYADLVKKFPNLNIAASGGVRSIEDFKE-LKKLGVNAAVFGRAYYEGML 232 Query: 240 NIGELKAYLATQ 251 + +L +++ + Sbjct: 233 KLEDLADFISEK 244 >UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=HIS4_BUCCC Length = 245 Score = 193 bits (490), Expect = 7e-48, Method: Composition-based stats. Identities = 49/251 (19%), Positives = 101/251 (40%), Gaps = 13/251 (5%) Query: 6 IIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP LD G++V+ Q DI ++Y +GA + D+ ++ Sbjct: 2 IIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENRQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 KS + + ++ F V GGI+S D + G KI I + A+ P + +G Sbjct: 62 KSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYGS 121 Query: 123 QCIVVGIDTWYD-AETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V+ +D + + K + + T+ D +++ G I+ +++ Sbjct: 122 KNFVLSVDININTKKENKIAIQGWKKT------TEINLDDAIKQFIPYGLKNILCTDISR 175 Query: 182 DGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG +G ++ K ++ + ++ L +SGG ++ + +V+ + + Sbjct: 176 DGTFSGPNISLYKYLKNKFPNIVLQSSGGINSISDIYN-LKKNNVEHVIVGRALLENKFT 234 Query: 241 IGEL-KAYLAT 250 E K +L Sbjct: 235 FLEASKCWLKE 245 >UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Gammaproteobacteria RepID=HIS4_SHEDO Length = 250 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 98/250 (39%), Gaps = 15/250 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ DGQVV+ Q + + K Y ++GA L D+T + D Sbjct: 2 IIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLKSYQDQGAKLLHIVDLTGAKDPNQRQ 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 +S + +D+ V GGI+S + ++L+ G ++ I S A+ +P L+ +++G Sbjct: 62 IKLISELVAGLDVDIQVGGGIRSEQQVTELLAIGVKRVVIGSLAVKEPELVKSWLNKYGS 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG-----AGEIVLN 177 I + +D +A K V E ++ G ++ Sbjct: 122 DAICLALDVNINANGEKI-----VAVSGWQSAGGKTLESLVAEFERPGSKQTALKHALVT 176 Query: 178 MMNQDGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +++DG G + ++ + ASGG T++ A +D+ G + Sbjct: 177 DISRDGTLTGANTALYTELAAAYPTILWQASGGIATLDDVS-AVKDSKAAGIIIGKALLI 235 Query: 237 QIINIGELKA 246 + E Sbjct: 236 NQFTVEEAIQ 245 >UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 n=15 Tax=Rhodobacterales RepID=HIS41_SILST Length = 247 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 93/255 (36%), Gaps = 15/255 (5%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +++ DG+ V + + D V AK +AE GA+ + D + G Sbjct: 1 MMIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFN-ALQGDS 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ V + +P + GGI+S E A + G ++ I + A DP + LA + Sbjct: 60 SNQDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYY 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q +V+ +D E + W +V+ I++ ++ Sbjct: 120 PDQ-VVLAVDV----------WQGQVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVTDID 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 D L + + E H P+IASG + + ++ GAL + I Sbjct: 169 SDMSDLDAQLGLISGLAEQAHSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTIT 228 Query: 241 IGELKAYLATQGVEI 255 + E + Sbjct: 229 LEEAMETAQPNPEPV 243 >UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Proteobacteria RepID=HIS4_DESOH Length = 251 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 54/252 (21%), Positives = 105/252 (41%), Gaps = 16/252 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++ G+ V+ +Q D +A+R+AE GA+ + D+ + + Sbjct: 1 MMVIPAVDIKGGKCVRLLQGDMNAETVFSDDPGAMAERWAEAGAELIHVVDLDGAIEKSP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + +S + + +P V GGI+ ++ G +I I S A+ P L+T F Sbjct: 61 RNLKAISALIRRVGVPVQVGGGIREIDTVKMYADLGVARIVIGSAAVNHPDLVTAACREF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + IV+GID + E T T D + G I ++ Sbjct: 121 PGR-IVLGIDAR----------DGRVATEGWTSTTDIAAADLAARFEGCGVAAINFTDIH 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF--RDADVDGALAASVFHKQI 238 +DG+R G ++ ++ +P++ASGG T++ ++ V G + + Sbjct: 170 RDGMRTGPNIPAIEAFARATAIPVVASGGVSTIDDIQALLGIQEFGVTGVITGRALYDGT 229 Query: 239 INIGELKAYLAT 250 +++ E A + Sbjct: 230 LDLAEAIAVASA 241 >UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=104 Tax=Bacteria RepID=HIS4_CLOB1 Length = 242 Score = 190 bits (484), Expect = 3e-47, Method: Composition-based stats. Identities = 56/250 (22%), Positives = 121/250 (48%), Gaps = 15/250 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I+P +D+++G+ ++ Q + + D + +A ++ E GA+ + D+ + G + Sbjct: 1 MIILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEI 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + S +S + + I+IP + GGI++L ++ G +++ + + AL + L+ ++ Sbjct: 61 KNLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I +GID + V+ +D+ +E++K G I+ ++ Sbjct: 121 -DEKIAIGIDAKNEK----------VAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDIS 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G +L+QL+K+ E + +IASGG +E + ++ DV GA+ + IN Sbjct: 170 KDGTLKGPNLKQLEKLNESINCNVIASGGIKDIEDL-KGIKEMDVYGAIVGKAIYSGNIN 228 Query: 241 IGELKAYLAT 250 + E + Sbjct: 229 LNEAIKIINK 238 >UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=cellular organisms RepID=HIS4_THEON Length = 229 Score = 190 bits (483), Expect = 4e-47, Method: Composition-based stats. Identities = 53/248 (21%), Positives = 103/248 (41%), Gaps = 22/248 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI--IGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 RI P +D+ G+ V+ + + ++ GD V +A R+ E D++ D+ + G+ Sbjct: 1 MRIYPAIDLMGGKAVRLYRGQKEKVKVYGDPVEIASRFTEL-VDKIHVVDLDGAFTGKPQ 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + V + E + V GG +S E AK GA+ + I + A D + ++ D F Sbjct: 60 NLDVVKEIIEETGLKVQVGGGFRSYESIAKAYEIGAENVIIGTKAF-DLEFLEKITDNFD 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + + DA GK V + + S E + ++E + + + Sbjct: 119 GITVSL------DARGGKIAVKGWLEESSLKVG---EAYEMLREY----VDRFIYTSIER 165 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG G E +++ + I +GG +++ L+ R GA+ ++ +++ Sbjct: 166 DGTLTGI--ESIERFWK--DEEFIYAGGVSSVDDVLK-LRRVGFSGAIVGKALYESEVSL 220 Query: 242 GELKAYLA 249 EL L Sbjct: 221 KELLEVLE 228 >UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Opitutaceae RepID=HIS4_OPITP Length = 243 Score = 190 bits (483), Expect = 4e-47, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 95/243 (39%), Gaps = 19/243 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D++ G+ V+ Q R + + +A ++ G++ + D+ + G Sbjct: 1 MTIYPAIDIKGGRCVRLTQGRAEQETIYAQNPADVAMQFRAAGSEWVHVVDLDGAFAGEP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + V + + + GG+++ + L+ G ++ + + A + + L F Sbjct: 61 QNLAAVQAIV-AVGMKVQFGGGLRTRAAVERALALGVSRVVLGTRAAESESFVGELVQAF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + V DA+ GK V + TL + + G ++ + Sbjct: 120 GDKIAVG-----IDAKNGKVAVKGWVAT------ADLSTLVLARRMDTLGVATLIHTDIG 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR----DADVDGALAASVFHK 236 DG+ G +L + + +IASGG + + + A++DG + ++ Sbjct: 169 TDGMLTGPNLAAQEALCSAVKSRVIASGGVSRRDDVVNLAKLAQRHANLDGVIVGKALYE 228 Query: 237 QII 239 + + Sbjct: 229 RRV 231 >UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUX9_ALIAD Length = 252 Score = 189 bits (481), Expect = 6e-47, Method: Composition-based stats. Identities = 63/252 (25%), Positives = 109/252 (43%), Gaps = 19/252 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D+ G+VV+ Q GD +A R + GA L D+ A+ G+ + Sbjct: 8 VYPAIDILGGEVVRLRQGDYQQVTRYDGDPAGVAGRLCDAGARFLHVVDLDAARSGQSDN 67 Query: 63 KSWVSRVAEVI---DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + V + E V GGI++ + A+ L G ++ I + A+ ++ A Sbjct: 68 ERAVRAIVETAASYGAAVQVGGGIRTKDAIARWLEAGVARVVIGT-AVRQVEVVAEWAQE 126 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG +V G+D T+W D +E+ K G + ++ + Sbjct: 127 FGGHRLVAGLDGRK----------GRLAVSGWLEETEWSIFDLARELAKVGLVQALVTDV 176 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G +L+ V+E + IASGG G+++ + A R A + GA+ H I Sbjct: 177 ERDGTGEGPNLDLALGVQE-TGLFAIASGGIGSIDDVV-AVRRAGLAGAVIGKALHDGRI 234 Query: 240 NIGELKAYLATQ 251 ++GEL LA + Sbjct: 235 HLGELFQRLAQE 246 >UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_SYMTH Length = 249 Score = 189 bits (481), Expect = 7e-47, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 106/257 (41%), Gaps = 20/257 (7%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDG 58 + + P +D++DGQVV+ Q R E D V +A R+AE GA + D+ + G Sbjct: 1 MRLDLYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRG 60 Query: 59 RVVDKSWVSRVAEVI-----DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 R + + V + E + + + GG+++LE L+ G + I + AL + Sbjct: 61 RPQNAAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSALEG-DVA 119 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 R RFG + V ID + VT+ +D +++ G Sbjct: 120 ARAVARFGPDRVAVSIDAR----------GGFVAARGWVEVTRVRAVDLAVRMREVGVRT 169 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 +V + DG+ G + +L+ + + +IASGG ++E V GA+ Sbjct: 170 VVYTDIATDGMLTGPNFAELEMMGR-TGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRA 228 Query: 234 FHKQIINIGELKAYLAT 250 + +++ E + Sbjct: 229 LYTGAVDLAEALSLCGE 245 >UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Vibrio vulnificus YJ016 RepID=HIS62_VIBVY Length = 272 Score = 189 bits (481), Expect = 8e-47, Method: Composition-based stats. Identities = 81/257 (31%), Positives = 124/257 (48%), Gaps = 6/257 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IPC+ + VV+ F+N+ IG++ + DE++ DI AS + R Sbjct: 4 MLKIRLIPCIVTKGELVVQSFAFKNYLPIGNVKTAIDFFVNWDVDEIIVNDIDASKEFRE 63 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + VS A+ +P V GGIK+LE +L GADK++IN+ A+ DP I A F Sbjct: 64 PNVDLVSWAAKECFVPLTVGGGIKTLEHIRNLLKAGADKVTINTKAIDDPDFIKNAASVF 123 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QCI V +D K + + V ++ GAGEI+LN ++ Sbjct: 124 GSQCITVSVDAIKQGNVYKLYDYRDGRVLDVDVVDWVRKVE------SYGAGEILLNSVD 177 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG R GYD+E LK V + +P+IA GG G + E + AA++F + Sbjct: 178 RDGSREGYDVELLKTVSGIVSIPVIALGGIGRFDQLAEGAIEGGCQALSAANIFQHMEHS 237 Query: 241 IGELKAYLATQGVEIRI 257 KA + + +R+ Sbjct: 238 TIAAKAQMRNAKLNVRL 254 >UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N0X3_9GAMM Length = 240 Score = 189 bits (480), Expect = 8e-47, Method: Composition-based stats. Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 12/246 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++ G+ V+ Q + +I V A +A+ GA L D+ + G + Sbjct: 1 MILIPAIDIQAGRCVRLKQGQFEQITIFDTPPVERAAYFAKIGAQRLHVVDLDGAQIGSM 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + I GGI+SLE A S G + + S A+++ L T++ Sbjct: 61 QQLPLICSM-QNTGINVQAGGGIRSLEQAKLCFSAGIANLVLGSIAISNRELATQIIQEI 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I++ +D + + + D V Q+ G +I+ + Sbjct: 120 SPKNIILALDIRLINGIPIPATHGWQTM------SNRNLWDVVSYYQQLGIQQILCTDIA 173 Query: 181 QDGVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG+ G + ++ V+ + ASGG E EA V A+ ++ + Sbjct: 174 CDGMMQGPNFSLYQEAVKRFPMIDWQASGGIRNQEDI-EALDKLGVAAAILGLSLYQGTL 232 Query: 240 NIGELK 245 ++ E K Sbjct: 233 HLAEYK 238 Score = 42.1 bits (98), Expect = 0.020, Method: Composition-based stats. Identities = 13/107 (12%), Positives = 39/107 (36%), Gaps = 6/107 (5%) Query: 156 QWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEH 215 ++ K GA + + ++ + + L + + + + + A GG ++E Sbjct: 29 DTPPVERAAYFAKIGAQRLHVVDLDGAQIGSMQQLPLICSM-QNTGINVQAGGGIRSLEQ 87 Query: 216 FLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGV----EIRIC 258 F A + + S+ ++ ++ + + +IR+ Sbjct: 88 AKLCF-SAGIANLVLGSIAISNRELATQIIQEISPKNIILALDIRLI 133 >UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SPR8_NEMVE Length = 545 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 95/332 (28%), Positives = 156/332 (46%), Gaps = 76/332 (22%) Query: 2 LAKRIIPCLDVRD---GQVV--KGVQFRNHEI----------------IGDIVPLAKRYA 40 LAKR+I L+VR G++V KG QF EI +GD V L +R+ Sbjct: 214 LAKRVITSLNVRTNNMGELVATKGEQFEVREIISDDEGNKPVKGDVKAVGDPVELGERFF 273 Query: 41 EEGADELVFYDITASSDGRVVDKSWVS---RVAEVIDIPFCVAGGIKS------------ 85 +GADE+ F +IT+ + D + + + E I +PF V GGI+ Sbjct: 274 SDGADEIAFLNITSFRSSPIHDLAMLKLLRKCCERIFVPFTVGGGIRDIYALDPDSVEEG 333 Query: 86 ---------LEDAAKILSFGADKISINSPALADPT-------------LITRLADRFGVQ 123 LE AA GADK+S+ S A+ I ++A+R+G Q Sbjct: 334 KPVMRQFSALEVAAMYFKSGADKVSVASDAVYAAEEFIASGHKKTGKTSIEKIAERYGRQ 393 Query: 124 CIVVGID------------------TWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQE 165 +V+ +D Y G+ +V + + V+ Sbjct: 394 AVVLAVDTKTVYVPSPDSTKHHTVKARYPGPNGEKYVWWQCTVKGGRETRDVGAYELVKA 453 Query: 166 VQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADV 225 ++ GAGEI+LN +++DG +GYDL+ +K V+ +P+IAS GAG + F++ FR+ + Sbjct: 454 CEELGAGEILLNNIDRDGTNHGYDLDLVKMVKGAVSIPVIASSGAGHVSDFVDLFRETNA 513 Query: 226 DGALAASVFHKQIINIGELKAYLATQGVEIRI 257 DGA+A ++FH+ ++I ++K +L +G +R+ Sbjct: 514 DGAMAGAIFHRGEVDITDVKEHLRNEGFTVRL 545 >UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW5_HODCD Length = 241 Score = 188 bits (479), Expect = 1e-46, Method: Composition-based stats. Identities = 42/251 (16%), Positives = 98/251 (39%), Gaps = 16/251 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 R + +DV++G+ V+ + + + +++ + D + D+ + G Sbjct: 1 MRFLASIDVKNGECVRLCRGQMADCRVYASSPLEAVRKFNLQCCDLVHIVDLDGAVCGSP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + A + V GG+++L DA L GA K+ + + A+AD + ++ + Sbjct: 61 QNWRSILEAARQLKGCVQVGGGVRTLADAKLYLEGGASKVVLGTSAIADMEFVCHVSWLY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + V G + + T V+ V +++ ++ +N Sbjct: 121 PGRVCV-----------GVDTFGELVATDGWTAVSCVRCDQLVPKLEAARVSCLIWTDIN 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGALAASVFHKQI 238 +DG G + + L +V VP+I SGG T ++ + G + +++ Sbjct: 170 RDGTLQGVNFDALDRVLAASAVPVIVSGGVATALDLIKLHNLYADKLAGVICGKALYERT 229 Query: 239 INIGELKAYLA 249 + ++ L+ Sbjct: 230 LTARFARSILS 240 >UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RFK6_LEGLO Length = 246 Score = 188 bits (478), Expect = 1e-46, Method: Composition-based stats. Identities = 45/247 (18%), Positives = 102/247 (41%), Gaps = 12/247 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D++ G+ V+ Q + ++ + A +A+ GA L D+ + G + Sbjct: 1 MILIPAIDLQAGRCVRLRQGQFDQVTQFDMSPIDRASYFAKLGAKRLHIVDLDGAKIGTM 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + + GGI+SLE A S G + I S A+ DP L T++ + Sbjct: 61 QQLPLICTM-QHTGVTVQAGGGIRSLEQAKTCYSAGISLLVIGSIAITDPGLTTKIINEI 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I++ +D + + + + + + V Q+ G +I+ + Sbjct: 120 SPKNIILALDIRMENKIPLPATHGWQTT------STMNLWEVVSFYQQLGITQILCTDIA 173 Query: 181 QDGVRNGYDLEQLKK-VREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 DG+ G + + ++ V ++ ASGG + + + + A+ ++ + Sbjct: 174 SDGMMQGPNFDLYQEAVERFPNIAWQASGGIRHQDDINK-LQKLGIKAAILGLTMYQDVF 232 Query: 240 NIGELKA 246 N+ + + Sbjct: 233 NLKSILS 239 >UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=2 Tax=Pedobacter RepID=C6Y3G6_PEDHD Length = 249 Score = 187 bits (475), Expect = 4e-46, Method: Composition-based stats. Identities = 49/252 (19%), Positives = 103/252 (40%), Gaps = 11/252 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+ DG+VV+ + I + + Y G + + D+ + G Sbjct: 1 MYIIPAIDILDGKVVRLTEGDYNQKTVYDVSIAEMIETYRSNGTEFIHIIDLNGAK-GDF 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + V + D+ GGI++++ +L G ++ + + A+ +P + L+ Sbjct: 60 SNQKALFEVIKKTDMRVQYGGGIRTIKQVTDLLDAGIHRVIVGTQAITNPDFLQELSKEV 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + D +++ + + +D+V + + G + +N Sbjct: 120 GKK-----YDYANRIVIAIDVLDEVIKYSGWMESSPIKLMDYVDKCLQLGFFRFLCTDIN 174 Query: 181 QDGVRNGYDLEQLKKVREVCH-VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G +E KK+ E + LIASGG +M+ E D+ + ++ I Sbjct: 175 KDGKLGGAAVELYKKLLEHSPFIKLIASGGVSSMKDIEE-LDKYDIRSVVVGKAIYENRI 233 Query: 240 NIGELKAYLATQ 251 I ++K + Q Sbjct: 234 TIDQIKEWNLKQ 245 >UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_ANADF Length = 238 Score = 186 bits (474), Expect = 4e-46, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 98/241 (40%), Gaps = 15/241 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ G+ V+ + A+ +A GA L D+ + G Sbjct: 1 MLVIPAIDLMGGEAVRLEKGDFATKTVYARHPAEKAEEFARAGATLLHVVDLDGAKAGWP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ V + EV I + GG++SL D K+L+ G + + + A+ L+ + RF Sbjct: 61 VNLDAVRAICEVPGIEVELGGGLRSLPDIEKVLALGVRYVVLGTAAVERLGLVEQACQRF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 Q G N T +D ++V+ G G + + Sbjct: 121 PGQV-----------RAGIDARNGEVKIAGWLEGTGLAAVDVARKVKGAGVGLVEYTDVA 169 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG+ G D +++ +P++ASGG +++ A R A + G + +++ I+ Sbjct: 170 RDGMFTGVDAAGAARIQAEAGIPVVASGGVASLDDV-TACRAAGLAGVIVGKALYERRID 228 Query: 241 I 241 + Sbjct: 229 L 229 >UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Archaeoglobaceae RepID=HIS4_ARCFU Length = 238 Score = 185 bits (471), Expect = 1e-45, Method: Composition-based stats. Identities = 45/246 (18%), Positives = 109/246 (44%), Gaps = 18/246 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRV 60 R+IP +D++DG+VV+ Q + E+ + + +AK++ E GA L D++ + GR+ Sbjct: 2 FRVIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRL 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + ++ +A++ + V GGI+ A ++ G D++ + A+ + A ++ Sbjct: 62 RHEEIIAEIAKMAE--VQVGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKW 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + +V D++ G+ V + V + + + + ++ Sbjct: 120 KGRVMVA-----IDSKKGRVAVKGWK------EVVELTPVQLAELYDDLDVS-FLYTNID 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G+ +G + E++++V + P+ +GG ++E + G + S + + + Sbjct: 168 VEGLVSGIERERIEEVVKSLRNPVYVAGGISSIEDI-RFAKRVGAAGVVIGSALYTKKLK 226 Query: 241 IGELKA 246 E Sbjct: 227 FEEAIK 232 >UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L5A7_9DELT Length = 261 Score = 185 bits (471), Expect = 1e-45, Method: Composition-based stats. Identities = 84/256 (32%), Positives = 131/256 (51%), Gaps = 7/256 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+IP + V+ G VV+ + FR + +G + + DE+V I D Sbjct: 1 MLKKRLIPVVLVKQGLVVQSIGFRRYLPVGRPKITVEFFNRWDCDEIVLLAIDREPD-LA 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + V+ +P V GG++ +ED ++L GADK+S+N+ A DP LITR A+ F Sbjct: 60 RLAGLTAHVSGAAFVPLTVGGGVRRIEDFQELLRAGADKVSLNTAAFRDPELITRAAEAF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +VV ID A+ T + D+ +E ++RGAGEI+LN ++ Sbjct: 120 GNQEVVVSIDARRHADG-----RYEVFVGGGREATGADPRDFAREAERRGAGEILLNAID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG + GYDLE +++V +P+IA GG G +EH EA A A+++FH + Sbjct: 175 RDGGKQGYDLELVRRVATAVSIPVIALGGVGRIEHVPEAIGAG-AAAAAASNIFHHIEHS 233 Query: 241 IGELKAYLATQGVEIR 256 K + G+ +R Sbjct: 234 TILAKQAMHKAGIAVR 249 >UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U8M5_HYDS0 Length = 234 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 51/244 (20%), Positives = 99/244 (40%), Gaps = 17/244 (6%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 + IIP +D++DG VV+ + + + + K + + G + D+ + G Sbjct: 1 MKDFIIPAIDIKDGAVVRLKEGKFENVKVYRQNPIDQFKLFVDLGFTRIHIVDLDGAKVG 60 Query: 59 RVVDKSWVSR-VAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + + + + D + GGI+SLE A + GAD I + + A+ D RL Sbjct: 61 IPKNLKLLEDMLKQKNDAKVEIGGGIRSLETAKALFEIGADYIIVGTLAVKDKEEFIRLL 120 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 + + + I+ DA+ GK + + + D + + Sbjct: 121 ELYKDRIIL-----SVDAKNGKVAIGGW------EEESSISPCDMARIYDNYPIESYLYT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +N DG G D+ K ++ P+IASGG ++E ++ V+G + ++ Sbjct: 170 NINIDGTLTGVDINPYKDFKKCTTKPIIASGGVASLEDVIKL--KTVVNGVVVGKAIYEN 227 Query: 238 IINI 241 I+I Sbjct: 228 KIDI 231 >UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=HIS4_THENN Length = 248 Score = 184 bits (468), Expect = 2e-45, Method: Composition-based stats. Identities = 51/260 (19%), Positives = 107/260 (41%), Gaps = 21/260 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +IP +D+ +VV+ V+ + D + L ++ EEG + D++ + + Sbjct: 1 MLVIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEESD 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + +++ D + GGI+ LE A K+L G + ++S L DP+ + +L + Sbjct: 61 ENLPVLEKLSSYAD-HIQIGGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKLKE-- 117 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I V D GK + ++ + + V +++ G EIV + Sbjct: 118 ----IGVNPVFSLDTREGKVAFKGWLDEK------DIDPVFLVNRLKEFGLEEIVHTEIE 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-----DADVDGALAASVFH 235 +DG +D +++ V +IA+GG + EA + + G + F Sbjct: 168 KDGTLKEHDFSLTERIALETGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGRAFL 227 Query: 236 KQIINIGELKAYLATQGVEI 255 + + + +K Y + + Sbjct: 228 EGTLTVEVMKRYACQENNSV 247 >UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sp. AT1b RepID=C4L175_EXISA Length = 237 Score = 184 bits (467), Expect = 3e-45, Method: Composition-based stats. Identities = 59/246 (23%), Positives = 110/246 (44%), Gaps = 16/246 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R++P +D+ G++V+ + E GD L K + + + D+ + G Sbjct: 1 MRLLPAIDLIGGKIVRLTEGDFSTEEQYGDPYELLKAWQGK-VPMIHLIDLEGAKAGEPR 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V A+ + GGI+S ++ GAD++ + + A DP + + +++G Sbjct: 60 HLDVVR-YAKSLGFLVQTGGGIRSEASLDAVMETGADRVLLGTKAFTDPDFLDKAIEKYG 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V DA GK +N + T+ + + Q++ KRG I+ + Sbjct: 119 KRVAVA-----LDAYDGKVAINGW------QEATKLDDISVAQDLVKRGIETILYTDIGS 167 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG NG ++ ++K +R++ +V LIASGG T E E + A +D A+ ++I Sbjct: 168 DGKLNGPNVTRMKALRQIVNVTLIASGGVTTEEDVKE-LKMAKIDEAVVGKALLSGKVSI 226 Query: 242 GELKAY 247 EL + Sbjct: 227 EELIEW 232 >UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WSE3_VEREI Length = 229 Score = 183 bits (466), Expect = 4e-45, Method: Composition-based stats. Identities = 80/218 (36%), Positives = 119/218 (54%), Gaps = 6/218 (2%) Query: 39 YAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGAD 98 Y +GADELVF DI AS R + R A+ I +P V GGI+SL D +L GAD Sbjct: 17 YYSQGADELVFMDIVASLYQRNNLAGIIERAADQIYVPITVGGGIRSLHDVRTMLCSGAD 76 Query: 99 KISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWE 158 K++IN+ A+A P LI +++RFG QC+V+ ++ + G ++ T + Sbjct: 77 KVAINTAAVARPGLIAEVSERFGSQCMVLSVEAKRKSGGGWEAF-----VDNGREHTGLD 131 Query: 159 TLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLE 218 + WV++ GAGEI+L ++Q+G R G+D++ ++ V VP+IASGG G + Sbjct: 132 VVAWVRQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTVAGCVTVPIIASGGYGRPSDLQQ 191 Query: 219 AFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIR 256 A +A G A H Q I ELKA+ G+E+R Sbjct: 192 A-AEAGASGLAIADALHWQRATIAELKAHARAAGLEVR 228 Score = 43.3 bits (101), Expect = 0.007, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 31/88 (35%) Query: 31 DIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAA 90 D+V ++ GA E++ + + D V VA + +P +GG D Sbjct: 131 DVVAWVRQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTVAGCVTVPIIASGGYGRPSDLQ 190 Query: 91 KILSFGADKISINSPALADPTLITRLAD 118 + GA ++I I L Sbjct: 191 QAAEAGASGLAIADALHWQRATIAELKA 218 >UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alphaproteobacteria RepID=HIS4_MARMM Length = 244 Score = 183 bits (464), Expect = 6e-45, Method: Composition-based stats. Identities = 45/252 (17%), Positives = 101/252 (40%), Gaps = 12/252 (4%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + P +D+ DG+VV+ + D + +A+++ E GA + D++ + DG Sbjct: 1 MILYPAIDLLDGRVVRLHKGAFDAVTDYGDDPMRVAEQFGEAGAVWVHIVDLSGARDGAR 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + + E + GG++S ED +L+ G +++ I S A+ D + + Sbjct: 61 RQGALIRSLCE-TGLRVQTGGGVRSAEDIEDLLAAGVERVIIGSLAVTDTNRVAGWLQNY 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G I + +D + + + T + D + + G ++ + Sbjct: 120 GGDRITLALDVRQIGGQYRPALKGW------TDMADTTLDDVISAYEGTGLAHALVTDIG 173 Query: 181 QDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG +G ++ K++ + ++ ASGG +++ A + ++ Sbjct: 174 RDGDLSGPNIALYKRLATDYPNIDWQASGGVSSLDDLRAARAAGAAGA-ITGKALYEGRF 232 Query: 240 NIGELKAYLATQ 251 +GE A L Sbjct: 233 TVGEAIACLRDA 244 >UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hisF n=2 Tax=Bacteria RepID=C9YDK8_9BURK Length = 286 Score = 182 bits (463), Expect = 8e-45, Method: Composition-based stats. Identities = 92/256 (35%), Positives = 134/256 (52%), Gaps = 5/256 (1%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML R+IP L + +VKGV F + +G ++P K Y + DELV DI A G Sbjct: 27 MLKVRVIPTLLWKHFGLVKGVGFNSWRRVGPVLPAIKVYNQREVDELVLVDILAHGRGEE 86 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + + +P V GGI +E ++L GADK+S+N+ A A P L++ +A R Sbjct: 87 PDYESIHEFGQDCFVPLTVGGGITHIEQVQRLLRVGADKVSLNTAAYARPELVSDIARRH 146 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 GVQC+V ID A G + T+ T + + W +E++ RGAGEI++ ++ Sbjct: 147 GVQCVVASIDVRPRAGGGW-----DCFSHAGTQPTGRDVVAWARELEDRGAGEILVTSID 201 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 DG GYDL + V + +P+IASGGAG +H ++A A AAS+FH + Sbjct: 202 LDGSMRGYDLALVAAVAQAVKIPVIASGGAGNYQHMVDAVVQAGAAAVAAASIFHFTEMT 261 Query: 241 IGELKAYLATQGVEIR 256 KA LA GV +R Sbjct: 262 PAGAKAALAEAGVPVR 277 >UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZVN4_9SPHI Length = 246 Score = 182 bits (463), Expect = 9e-45, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 101/249 (40%), Gaps = 15/249 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 +I+P + + G+VV+ ++ + + + LA + G L D+ + ++ Sbjct: 2 IKIVPSIAILGGKVVRTIKGDIDQVQVYDTNPLDLALEFENNGIKHLHLVDLDGAKARQI 61 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V+ + + +A + GGI +D GA ++ + A+ + + Sbjct: 62 VNYNILEMLASYTQLEIDYTGGITRDDDIRTAFECGAKHVTAATVAVHEREKFLSWVITY 121 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G +++ D ++ + + T + ++ ++ +RG + + Sbjct: 122 GGNKVILAAD----------ALDGVVLTKGWRKNTGIDLVEHIKSYHERGVRFVKTTEIG 171 Query: 181 QDGVRNGYDLEQLKKVR-EVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 ++G G + + KK+R E + ++ASGG ++E E V G + ++ I Sbjct: 172 RNGTLEGPNFDTYKKLRTEFPELQILASGGIRSIEDI-EQLDALGVAGVIIGKSYYDGQI 230 Query: 240 NIGELKAYL 248 + +L+ ++ Sbjct: 231 KLKDLQKFI 239 Score = 52.5 bits (125), Expect = 1e-05, Method: Composition-based stats. Identities = 22/120 (18%), Positives = 41/120 (34%), Gaps = 7/120 (5%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADEL--VFYDITASSDGRVVD 62 ++I D DG V + D+V K Y E G + + +G + Sbjct: 125 KVILAADALDGVV--LTKGWRKNTGIDLVEHIKSYHERGVRFVKTTEIGRNGTLEG--PN 180 Query: 63 KSWVSRVAEVID-IPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 ++ + +GGI+S+ED ++ + G + I + L G Sbjct: 181 FDTYKKLRTEFPELQILASGGIRSIEDIEQLDALGVAGVIIGKSYYDGQIKLKDLQKFIG 240 >UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes: glutamine amidotransferase; cyclase], putative n=6 Tax=cellular organisms RepID=B9WJS1_CANDC Length = 622 Score = 182 bits (462), Expect = 1e-44, Method: Composition-based stats. Identities = 92/329 (27%), Positives = 145/329 (44%), Gaps = 73/329 (22%) Query: 2 LAKRIIPCLDVR---DGQVV--KGVQFR----------------NHEIIGDIVPLAKRYA 40 L +RII CLDVR DG +V KG Q+ +G V LA +Y Sbjct: 288 LTRRIIACLDVRTNDDGDLVVTKGDQYNVREQQSSSSKISENSNQVRNLGKPVELATKYY 347 Query: 41 EEGADELVFYDITASSDGRVVDKSWV---SRVAEVIDIPFCVAGGIKSLED--------- 88 +GADE+ F +IT+ + + D + + AE I +P V GGIK L D Sbjct: 348 NQGADEITFLNITSFRNSPLKDLPMLQVLRKSAETIFVPLTVGGGIKDLYDSETKKIIPA 407 Query: 89 ---AAKILSFGADKISINSPALADPT-------------LITRLADRFGVQCIVVGIDTW 132 A GADKISI S A+ I ++ +FG Q +V+ +D Sbjct: 408 VDIAHLYFQSGADKISIGSDAVIIAENYYANNQIPLGTSSIETISSKFGNQAVVISVDPK 467 Query: 133 YD----------------------AETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 G+ + + ++ + L+ +K G Sbjct: 468 RKYIKNPQLDTTMETIKIIDPLQYGPNGEQYCYYQVTSQGGRKLHELGALELCLACEKLG 527 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-DADVDGAL 229 AGEI+LN ++ DG G++L+ L++++ +P+IAS GAG +HF + F D +D AL Sbjct: 528 AGEILLNSIDNDGSNKGFNLQLLQQIKSHVSIPVIASSGAGNPQHFQQVFEMDCGIDAAL 587 Query: 230 AASVFHKQIINIGELKAYLATQ-GVEIRI 257 A +FH+ + E+K YL + +++R+ Sbjct: 588 GAGIFHRGEYTVNEVKKYLQQEAKMDVRL 616 >UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UE29_9RHOB Length = 261 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 79/268 (29%), Positives = 128/268 (47%), Gaps = 18/268 (6%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI-------- 52 ML R+IP L + +GQ+V+ F H+IIGD + R+ E DEL++ DI Sbjct: 1 MLMPRLIPVLLLMNGQLVRSETFTTHQIIGDPLHEVARFNEWKVDELIYLDISRTAGLAQ 60 Query: 53 ---TASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALAD 109 A + + VA +P G + SL+ I GADK++IN+ A Sbjct: 61 GRRDAGNRAYADAMDVLEAVASHCFMPLTWGGHVTSLDQVRDIFKRGADKVAINTAAYET 120 Query: 110 PTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR 169 P LIT+++ RFG Q +VV ID + + T + + W +E + R Sbjct: 121 PDLITQVSKRFGAQAMVVSIDARQIENGYEVM------TQGGRTATGRDPVSWAKEAEDR 174 Query: 170 GAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGAL 229 GAGEI+L +++DG GYD +++V + +P+IA G G EH+ + + A Sbjct: 175 GAGEILLQSLDRDGRGTGYDTTLIEQVSQAVTIPVIACSGVGVYEHYAKGLKAGADAVAA 234 Query: 230 AASVFHKQIINIGELKAYLATQGVEIRI 257 A +++H + + K L G ++R+ Sbjct: 235 A-NIWHFKELADRGGKRALQRAGFDVRM 261 >UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6XVQ0_PEDHD Length = 288 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 76/256 (29%), Positives = 128/256 (50%), Gaps = 7/256 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ML KR+ L V+DG VV+ + F+ + +G + + G DE++ DI+A+ Sbjct: 1 MLKKRVAANLVVKDGIVVQSIGFKKYLPVGKPEIAIEFLNQWGIDEIILTDISATRKQSG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D + R A+ +P V GGI + ++L GADKIS+N+ A+ P LIT A F Sbjct: 61 PDFDMIRRAAQKCFVPLTVGGGISNTGQMKELLHNGADKISLNNAAITTPELITETAHIF 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G QC+V+ ID + + + + ++ + + GAGEI++N ++ Sbjct: 121 GGQCVVISIDGIHTNKGFRIYDY------LTHSALDISPSEFAKRAEDSGAGEILINSVD 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG G+D E + V V ++P+I GGA F+E F + A AA+ FH + Sbjct: 175 RDGSYLGFDHELINSVCSVVNIPVIVCGGAKNAGDFIEVFSKTNASAATAANFFHFSEHS 234 Query: 241 IGELKAYLATQGVEIR 256 + K+ L + +++R Sbjct: 235 VNITKSIL-NKKMDVR 249 >UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms RepID=C1FJN8_9CHLO Length = 601 Score = 181 bits (459), Expect = 2e-44, Method: Composition-based stats. Identities = 88/311 (28%), Positives = 134/311 (43%), Gaps = 58/311 (18%) Query: 2 LAKRIIPCLDVRDG-----QVVKGVQ--------FRNHEIIGDIVPLAKRYAEEGADELV 48 LAKR+I CLDVR V KG + +G V LA +Y ++GADE+ Sbjct: 283 LAKRVIACLDVRSNDAGDLVVTKGDSYDVREKDDGNDVRNLGKPVELAGKYFKQGADEVA 342 Query: 49 FYDITASSD---GRVVDKSWVSRVAEVIDIPFCVAGGIKSLED-----------AAKILS 94 F +IT D + R +E + +P V GGI+ D AA Sbjct: 343 FLNITGYRDLPLTDAPMLEVLRRSSETVFVPLTVGGGIRDFTDSNGVSYTALEVAAAYFK 402 Query: 95 FGADKISINSPALA-------------DPTLITRLADRFGVQCIVVGIDTWY-------- 133 GADK+SI S A+ T I ++++R+GVQ +VV ID Sbjct: 403 AGADKVSIGSDAVYVAEQYYANDKKKDGCTSIEQISERYGVQAMVVSIDPRRAYVADPSE 462 Query: 134 ----------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 G+ +V + + ++ G GEI+LN +++DG Sbjct: 463 TKNRCIKTSRPGPNGEEYVWFQCTVKGGREGRDIGAYELAIAMEDLGCGEILLNCIDEDG 522 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 NG+D E + V + +P+IAS GAG +HF + F ALAA +FH+ ++I E Sbjct: 523 QGNGFDHELVGLVADAVTIPVIASSGAGEPKHFTDVFNATKCSAALAAGIFHRGEVDISE 582 Query: 244 LKAYLATQGVE 254 +K ++ + Sbjct: 583 VKDHMKGGKIP 593 >UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B860_THEAS Length = 232 Score = 181 bits (459), Expect = 3e-44, Method: Composition-based stats. Identities = 51/246 (20%), Positives = 92/246 (37%), Gaps = 18/246 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 I P +D+ G+VV+ R +A +A+ G D+ + GR Sbjct: 1 MEIYPAVDLYGGKVVRLTGGRFQDATVYPTSPGEMALLFAQAGVRWAHVVDLEGAKTGRP 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 V + A + GGI+S++ LS GA ++ + S + F Sbjct: 61 VHLWALEAFAGA-GLKVQFGGGIRSIQSVRDALSAGATRVMMGSALFDRSVDVVEAHRLF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G + D + V + T+ T ++ + + G ++ + Sbjct: 120 GPAIL-----PAVDHRGWRVSVKGW------TQGTDIPVDRALENLSRVGFSLFLVTDGD 168 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +DG +G DLE +K+ + IA+GG G + H R+A GA+ ++ I+ Sbjct: 169 RDGTLSGPDLEGYRKICARYGI--IAAGGIGELGHL-RGLRNAGAAGAVLGKALYEGAIS 225 Query: 241 IGELKA 246 I E Sbjct: 226 IEEAMR 231 >UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ6_9ACTN Length = 247 Score = 180 bits (458), Expect = 3e-44, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 105/257 (40%), Gaps = 20/257 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGR- 59 + P +D+ G+VV+ + D V +A+ +AE+GA + D++++ Sbjct: 1 MILFPAIDLIGGKVVRLERGDRSRCKVYSDDPVAVARSFAEQGASWVHVVDLSSAFGEDE 60 Query: 60 ---VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + + + + V + V GG++SL ++ +GA +I++ + + +P Sbjct: 61 DTCAANSAAIKAICGVDGLSVDVGGGVRSLARIDELAGYGARRIALGTVLVTEPGFAEVA 120 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 A FG + +V I + D V ++ + G +V Sbjct: 121 AQGFG-ELLVADIAAR----------DGQVKVNGWRDGAGVALDDAVAQLSELGFKHLVY 169 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL--EAFRDADVDGALAASVF 234 + +DG++ G D+ + V EV P++ASGG ++ A + ++GA+ Sbjct: 170 TDIARDGMQTGIDVAAYRHVAEVAGFPVVASGGISALDDIRALAAVGEGAIEGAITGRAL 229 Query: 235 HKQIINIGELKAYLATQ 251 ++ + + A + Sbjct: 230 YEGNFTLAQALAAARGE 246 >UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=uncultured marine bacterium 440 RepID=Q6SHC0_9BACT Length = 262 Score = 180 bits (457), Expect = 4e-44, Method: Composition-based stats. Identities = 77/263 (29%), Positives = 134/263 (50%), Gaps = 17/263 (6%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSD---GRVV 61 RIIP L +++G +V+ F H+ IG+++ AKR + DELV+ DIT + + GR Sbjct: 6 RIIPVLFIKNGLIVRSQNFYKHQFIGNVIEQAKRLNDYDVDELVYIDITRNDNYDLGRDD 65 Query: 62 DK--------SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 S + +++V +P GGI+S++DA + GADKI+INS D ++ Sbjct: 66 LLVKSKRDIMSIIKDISKVCFMPLTFGGGIRSVDDAVNRIRAGADKITINSLLYKDLNIV 125 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 ++ G Q +V ID E + T E +D++++++ G GE Sbjct: 126 KKIISEIGSQAVVASIDYKIINE------KLIIFNNFGQDNTNIELIDFIKKIENLGVGE 179 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 + + DG++ G+DL +KK+ ++P+IA GAG++EHFLEA + + A + Sbjct: 180 FFIQNVELDGMQKGFDLNNIKKIVNSVNLPVIACSGAGSLEHFLEAVKIKGLSAVAAGNY 239 Query: 234 FHKQIINIGELKAYLATQGVEIR 256 F+ + + +K L + +R Sbjct: 240 FNYKERSYPIIKKELKDFNINVR 262 >UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HIS4_RUBXD Length = 243 Score = 179 bits (455), Expect = 8e-44, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 98/246 (39%), Gaps = 16/246 (6%) Query: 6 IIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 + P +D++ G+ V+ Q D V A+ + GA L D+ + +GR V Sbjct: 9 VFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPVQ 68 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + + +A +P V GGI++LED GA ++ + + A+AD R + G Sbjct: 69 LALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELGA 128 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 +VV +D R + + E+ G ++ +++D Sbjct: 129 D-LVVAVDAR----------EGVVATHGWQRQSGVGAAELAGELAAEGVRAVLFTDISRD 177 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G G LE+ +V + +P IASGG R V GA+ + ++ + Sbjct: 178 GTGEGAALERTAEVAGI--IPTIASGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLE 235 Query: 243 ELKAYL 248 EL A Sbjct: 236 ELLAAA 241 >UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LAC8_MAGSM Length = 260 Score = 176 bits (448), Expect = 4e-43, Method: Composition-based stats. Identities = 66/224 (29%), Positives = 113/224 (50%), Gaps = 7/224 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 M R+IP L +++G++VK V+F +GD V AK + ++ DEL DI+AS G Sbjct: 1 MRRIRVIPTLLLKEGRLVKTVRFNQAKATYVGDPVNTAKIFNDKEVDELAVLDISASRRG 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 D V ++A +P GG+++L+ ++ G +K+ +N+ + L+ Sbjct: 61 AEPDFECVEQLASECFMPLLYGGGVRNLQQIQRLFHSGVEKVMLNTAFFSGSGLLQEAVK 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 +G Q + V ID D + R T + + Q+ ++ GAGE++LN Sbjct: 121 IYGSQSLGVSIDVKKDLWG-----RYRVMSQGGQRKTGLDPVVAAQQAEQAGAGELLLNA 175 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRD 222 M+QDG++ GYDLE +++V +P+IA GGA ++ F Sbjct: 176 MDQDGMQQGYDLELVQRVSRGVAIPVIAVGGAASVADFRTVVTQ 219 Score = 55.6 bits (133), Expect = 2e-06, Method: Composition-based stats. Identities = 14/100 (14%), Positives = 39/100 (39%), Gaps = 1/100 (1%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL 217 + ++ + + E+ + ++ D E ++++ C +PL+ GG ++ Sbjct: 33 DPVNTAKIFNDKEVDELAVLDISASRRGAEPDFECVEQLASECFMPLLYGGGVRNLQQIQ 92 Query: 218 EAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 F + V+ + + F + E +Q + + I Sbjct: 93 RLF-HSGVEKVMLNTAFFSGSGLLQEAVKIYGSQSLGVSI 131 >UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Dictyoglomus RepID=HIS4_DICT6 Length = 242 Score = 176 bits (448), Expect = 5e-43, Method: Composition-based stats. Identities = 50/254 (19%), Positives = 102/254 (40%), Gaps = 20/254 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +D+ +VV+ + +I+ + + LAK + E+GA L D+ ++ D Sbjct: 1 MLIIPAIDIYKHKVVRMETGKKEKIVLEFNNPLDLAKYWEEKGAKALHLIDLQSAIDAND 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 KS V + + IP V GG +S E + +S+G ++ ++S + + L ++ Sbjct: 61 ESKSIVRDIVRSVSIPVEVGGGYRSREKIEEAISWGVWRVIVSSILGMELDYLLDLFSKY 120 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + I D GK + + D +++ E++ ++ Sbjct: 121 ENKII-----PSIDWYDGKVGIKGWQDFIEWR--------DIKRKIDLLKVREVIFTDIS 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR----DADVDGALAASVFHK 236 +DG G +LE +K + + +GG ++E ++ + G + + Sbjct: 168 RDGTLKGVNLENIKNFLSLHDYDVWIAGGISSIEDVIKIKDLSENTGRIKGIIIGRALLE 227 Query: 237 QIINIGELKAYLAT 250 IN E K + Sbjct: 228 GKINWEEAKKIIDA 241 >UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8V9_IGNH4 Length = 235 Score = 176 bits (447), Expect = 6e-43, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 104/247 (42%), Gaps = 19/247 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 R+ P +DV +G+ VK V+ +GD V A+ +A EGA L D+ + G+ + Sbjct: 1 MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPI 60 Query: 62 DKSWVSRV---AEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + +++V A+ + VAGG++ +E + AD I S A DP + ++ Sbjct: 61 NVEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPK--ADAFVIGSRAHKDPEFLEVASE 118 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 G ++V ID GK V + + +++ + R + Sbjct: 119 AVGADKVIVAIDLK----GGKVSVEGWK------EEIPVGLKEALEKFKGRSFRGFLYTY 168 Query: 179 MNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 ++ +G G D+ +K + RE L +GG G+ EH + A D + + Sbjct: 169 VDTEGTMEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHV-KLLESAGADVVVLGMALYSG 227 Query: 238 IINIGEL 244 + + +L Sbjct: 228 KLRLKDL 234 >UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n=3 Tax=Basidiomycota RepID=Q5KNA0_CRYNE Length = 619 Score = 174 bits (441), Expect = 3e-42, Method: Composition-based stats. Identities = 89/331 (26%), Positives = 131/331 (39%), Gaps = 76/331 (22%) Query: 2 LAKRIIPCLDVRDG-----QVVKGVQFRNHEIIGD--------IVPLAKRYAEEGADELV 48 L RI+ CLDVR V KG Q+ E D V LA+RY GADE+ Sbjct: 282 LTNRIVACLDVRSNDAGDLVVTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVA 341 Query: 49 FYDITASSDG---RVVDKSWVSRVAEVIDIPFCVAGGIKS-----------LEDAAKILS 94 F +IT+ V AE + +P + GGIK LE A Sbjct: 342 FLNITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFR 401 Query: 95 FGADKISINSPALADPTL-----------------ITRLADRFGVQCIVVGIDTWYDAET 137 GADK+SI S A+ I ++ +G Q +VV ID Sbjct: 402 SGADKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVD 461 Query: 138 --------------------------------GKYHVNQYTGDESRTRVTQWETLDWVQE 165 V + + Q Sbjct: 462 TSAPGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQCTISGGRAVRDIDVVQLAQG 521 Query: 166 VQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADV 225 V++ GAGEI+LN +++DG G+DL+ +K V+ +P+++S GAG+ F E FR+ Sbjct: 522 VERLGAGEILLNSVDRDGSGQGFDLDLVKLVKNAVGIPVVSSSGAGSPADFEEVFRETGT 581 Query: 226 DGALAASVFHKQIINIGELKAYLATQGVEIR 256 + ALAA +FH+ + I E+K +L + + +R Sbjct: 582 EAALAAGIFHRGEVGIDEVKGWLEGKEMAVR 612 >UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZQ4_9SPHI Length = 250 Score = 173 bits (440), Expect = 4e-42, Method: Composition-based stats. Identities = 41/251 (16%), Positives = 101/251 (40%), Gaps = 10/251 (3%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH---EIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 IIP +DV D +VV+ + + RY G + + D+ + G Sbjct: 1 MYIIPAIDVLDKKVVRLREGNYDDVTTYDISLEEQIDRYHANGTELVHIIDLNGAK-GDF 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ ++ + ++ GG++S+E +++ G ++ + + A+ +P + L+ Sbjct: 60 SNQEYLFNIIRKTEMKIQYGGGVRSIEKVKELIDAGVFRVIVGTQAITNPEFLEELSTL- 118 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 + + D A V +Y + + ++++ + G + ++ Sbjct: 119 -NEGKIKYADHIVIAIDVLDEVIKY---SGWLESSPIKLIEYIDKCLALGFYRFLCTDIS 174 Query: 181 QDGVRNGYDLEQLKKVREVCH-VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +DG G +E KK+ + + LI SGG +M+ + ++ + ++ I Sbjct: 175 KDGKLGGAGVELYKKLLDHSPIIKLIGSGGISSMDDIRKLQELGRMESCVVGKAIYENRI 234 Query: 240 NIGELKAYLAT 250 +I E++ + Sbjct: 235 SIEEIQDWNLK 245 >UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=4 Tax=Vibrio RepID=A6Y2G9_VIBCH Length = 262 Score = 173 bits (438), Expect = 6e-42, Method: Composition-based stats. Identities = 48/261 (18%), Positives = 104/261 (39%), Gaps = 20/261 (7%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQF--------RNHEIIGDIVPLAKRYAEEGADELVFYDI 52 M ++ P +D+ G+ + +G++ +A+ + + GA + D+ Sbjct: 1 MEEFKLYPSIDIVGGKALTSRSAIDITLGITEEKTYLGEVFEVAELHFQSGAKWIHIVDL 60 Query: 53 TASSDGRVVDKSWVSRVAEVIDIPFC--VAGGIKSLEDAAKILSFGADKISINSPALADP 110 A+ G ++ + + + V GGI+S E + + G +++I+S P Sbjct: 61 DAA-SGVGSNQRLIMDLVKHFSEKVQTQVCGGIRSNEILEQYILAGCSRVNISSMIFDKP 119 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 L +L ++G + I + +D + K + + W TLDW + G Sbjct: 120 KLCEKLLKKYG-EKIAIALDVKLVNQEYKLATRGWNTLQGNL----WTTLDW---LDNSG 171 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALA 230 VL +++ G N + L++V P+I+ GG +++ + ++GA+ Sbjct: 172 CQRYVLTDVDRGGSLNHPNFSLLEQVLTKTSTPIISGGGLCSLDDI-DRLYQIGIEGAVL 230 Query: 231 ASVFHKQIINIGELKAYLATQ 251 + H Q + Y+ Sbjct: 231 GQLIHTQQHQLKRFLQYVQQN 251 >UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8LDL7_THAPS Length = 570 Score = 171 bits (435), Expect = 1e-41, Method: Composition-based stats. Identities = 87/325 (26%), Positives = 136/325 (41%), Gaps = 69/325 (21%) Query: 2 LAKRIIPCLDVRDG-----QVVKGVQFR--------------NHEIIGDIVPLAKRYAEE 42 L KR++ LDVR V KG Q+ +G V LA RY +E Sbjct: 244 LVKRVVVALDVRSNDHGDLVVTKGDQYDVRENEKEGVQEGRGGVRNLGKPVSLASRYYKE 303 Query: 43 GADELVFYDITASSDG---RVVDKSWVSRVAEVIDIPFCVAGGIKSLED----------- 88 GADE+ F +IT+ G + + ++ I +P V GGI+S ED Sbjct: 304 GADEIAFLNITSFRSGVIEDMPMLQVLEEASKEIFVPLTVGGGIRSYEDPGTGKVYSALE 363 Query: 89 -AAKILSFGADKISINSPALADPT-------------LITRLADRFGVQCIVVGIDTWY- 133 A++ GADK+SI S ++ I ++ +GVQ +V+ ID Sbjct: 364 VASRYFRAGADKVSIGSDSVHAAEEYIASGNTKTGQTSIETISHVYGVQAVVISIDPKRV 423 Query: 134 ---------------------DAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 G+ + + + + + GAG Sbjct: 424 YVTSPDAADSKHTVVTLDDSQKGPNGEQYCWYQCTVKGGREARDICAVSVAKAAEALGAG 483 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 EI+LN ++ DG NG+D +K V + +P+IAS GAG HF + F + V ALAA Sbjct: 484 EIMLNCIDMDGQCNGFDHALMKAVSDAVTIPVIASSGAGKESHFSDVFSETSVQAALAAG 543 Query: 233 VFHKQIINIGELKAYLATQGVEIRI 257 +FH++ + I ++K ++ G+ RI Sbjct: 544 MFHRKEVEIADVKKHMEKMGIRARI 568 >UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit HisF n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BR00_9RICK Length = 254 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 81/257 (31%), Positives = 135/257 (52%), Gaps = 10/257 (3%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNH-EIIGDIVPLAKRYAEEGADELVFYDITASSDGR 59 ML RII + +VKG +F N G + K Y DE++F+DI+ + + Sbjct: 1 MLKARIITTMLWNGSTLVKGNKFENEKRSAGSPLTTVKIYNSRDVDEILFFDISR--NNK 58 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 ++DK ++ + + + +P + GGI+ + + +GADK++INS +P +I + R Sbjct: 59 IIDKDFILSITDCVSVPITIGGGIEKISQMNDLFEYGADKVAINSIIYKNPNIIDEASKR 118 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 FG Q I V ID + + + + + + D + E RGAGEIV+N + Sbjct: 119 FGSQAITVSIDVRKNNQNYE------CYYDLGKIKSDRKLNDLLVECVNRGAGEIVINCI 172 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 N DG+ GYD E +++ + ++P++ASGGAG+ EHF EA+++ D AAS++H Sbjct: 173 NNDGLMKGYDNELIQQTSSLANIPIVASGGAGSYEHFYEAYKN-GADAFAAASIYHFTEH 231 Query: 240 NIGELKAYLATQGVEIR 256 + K YL + V IR Sbjct: 232 TPAKAKKYLLKKKVPIR 248 Score = 51.8 bits (123), Expect = 2e-05, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 38/105 (36%), Gaps = 3/105 (2%) Query: 153 RVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGT 212 + + L V+ R EI+ ++++ D + + + + VP+ GG Sbjct: 27 KRSAGSPLTTVKIYNSRDVDEILFFDISRNNKI--IDKDFILSITDCVSVPITIGGGIEK 84 Query: 213 MEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 + + F D S+ +K I E +Q + + I Sbjct: 85 ISQMNDLFEY-GADKVAINSIIYKNPNIIDEASKRFGSQAITVSI 128 >UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID=Q1N2Y7_9GAMM Length = 223 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 67/230 (29%), Positives = 121/230 (52%), Gaps = 8/230 (3%) Query: 29 IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED 88 +GD + K ++ ADE+V DI A+ R ++ + R++ +P + GG+ +LED Sbjct: 2 VGDAITNVKVFSSRKADEMVIVDIEATEKKR-INLPLLKRLSSHCIMPLTIGGGVTTLED 60 Query: 89 AAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGD 148 A + S GADK+ +NS P ++T ++ +FG Q +V +D + Sbjct: 61 AEDLFSVGADKVLVNSAFYNRPEILTDISSKFGRQAVVFSLDVMKKSNEY------VPVS 114 Query: 149 ESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASG 208 ++ + W + V+ + GAGEI+LN ++ DG+ G+DL K+V ++ VP++ +G Sbjct: 115 KNGSVKQSWTLRETVERAIEYGAGEIILNSVDCDGMMQGFDLNLCKQVSDISSVPVVIAG 174 Query: 209 GAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRIC 258 G GT E + A ++ D A S+F+ +I +K Y+ G+E+R+ Sbjct: 175 GCGTKEDCVLAV-NSGADAVAAGSIFYWVGESILTIKDYMNKNGLEVRLL 223 >UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase subunit n=1 Tax=Erythrobacter litoralis HTCC2594 RepID=Q2N6D2_ERYLH Length = 264 Score = 170 bits (432), Expect = 3e-41, Method: Composition-based stats. Identities = 64/220 (29%), Positives = 108/220 (49%), Gaps = 6/220 (2%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 M RIIP L + VK QF+ IGDIV A+ + + ADEL+ DI Sbjct: 1 MRRLRIIPVLLLDGTSAVKTHQFKPARYIGDIVNAAQIFNSKMADELIVVDI-GYHQDNP 59 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + +AE +P GGI S+++AA + G +K+SIN+ + L+ A +F Sbjct: 60 SRPEVIRHLAEECFMPLAFGGGISSVDEAAALFKDGIEKVSINTAFVEGGALVEEAARQF 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V ID +A+ TR + ++ + + +GAGEI++ ++ Sbjct: 120 GSQSVVASIDARREADGSY-----QVYSRGGTRALGIDPVEMARRAEAQGAGEILIQSID 174 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 +DG+R GYD ++ + + +P++A GGA T++ + Sbjct: 175 RDGMRKGYDRNLVRSIVDATTLPVVALGGADTVDDLAQVI 214 >UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermotogaceae RepID=HIS4_THEP1 Length = 241 Score = 170 bits (430), Expect = 6e-41, Method: Composition-based stats. Identities = 51/254 (20%), Positives = 106/254 (41%), Gaps = 21/254 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE---IIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 ++P +D+ G+V + V+ + D L K+ EEG + D++ + + V Sbjct: 1 MLVVPAIDLFRGKVARMVKGKKENTIFYEKDPAELVKKLIEEGFTLIHVVDLSKAIENSV 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 + + R++E + + GGI+S + A ++ G + ++S L DP+ + L + Sbjct: 61 ENFPVLERLSEFAE-HIQIGGGIRSFDYAERLRKLGYKRQIVSSKVLEDPSFLKFLKE-- 117 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 I V D GK + +E + + + ++ +++ G EIV + Sbjct: 118 ----IDVEPVFSLDTRGGKVAFKGWLAEE------EIDPISLLKRLKEYGLEEIVHTEIE 167 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR-----DADVDGALAASVFH 235 +DG +D +K+ V + A+GG + A R + + G + F Sbjct: 168 KDGTLQEHDFSLTRKIAIEAEVNVFAAGGISSENSLKTAQRVHRETNGLLKGVIVGRAFL 227 Query: 236 KQIINIGELKAYLA 249 + I+ + +K Y Sbjct: 228 EGILTVEVMKRYAR 241 >UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. BL107 RepID=Q062W6_9SYNE Length = 255 Score = 169 bits (429), Expect = 8e-41, Method: Composition-based stats. Identities = 72/261 (27%), Positives = 120/261 (45%), Gaps = 11/261 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYA----EEGADELVFYDITASS 56 M KR+I L + G F + IG++ L Y DELV D++ Sbjct: 1 MAKKRLIFTLLYQKGGFYLSRNF-RLQKIGNLSWLKINYNFYSVACAIDELVILDVSREK 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 R V+ V + +P + G I SL+DA ++ GADK+ IN+ +P L+ L Sbjct: 60 PDRQEFCEVVNEVCQNCFMPLALGGHINSLDDAKMLIYNGADKLIINTALHENPNLVREL 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 +G QCI+ +D E G + V G + R + ++ + + G GE+ L Sbjct: 120 IAIYGSQCIIGSVDYKI--EEGSFIVYTNQGKKRLDRPLN----EHIERLGEMGVGELYL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 N +++DG GY E LK++ H+P+I +GGAG H E+ VD A++ + Sbjct: 174 NSIDRDGTGQGYVSEVLKQLDSASHLPIIQAGGAGNKHHLQESLECRGVDAVATANLLNF 233 Query: 237 QIINIGELKAYLATQGVEIRI 257 + + + +L +G+ + I Sbjct: 234 VGDGLPKAREFLINKGISMAI 254 >UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase n=2 Tax=Rothia mucilaginosa RepID=D2NNQ2_9MICC Length = 262 Score = 168 bits (427), Expect = 1e-40, Method: Composition-based stats. Identities = 46/263 (17%), Positives = 103/263 (39%), Gaps = 23/263 (8%) Query: 5 RIIPCLDVRDGQVVKGVQF--RNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 ++P +D+ +G V+ V E D V A + + GA + D+ + GR + Sbjct: 7 ELLPAVDISEGYAVRPVGGTLSGGEQRLDPVEAALTWVKAGARWIHLVDLDLAF-GRGTN 65 Query: 63 KSWVSRVAEVI-----------DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 ++ V + + V+GG+++ E + LS D++++ S ALAD + Sbjct: 66 TEVLAEVVAAVRAENARMTGSAPVRIQVSGGVRNPESLERALSLNPDRVNVTSAALADSS 125 Query: 112 LITRLADRF-GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 + R+ + +G+D Y E + T + + + ++ G Sbjct: 126 WLEGTLARYADSDLLALGLDARYTPE------RGWVTVARGTDWSGPGVAEALAWLEGAG 179 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEA--FRDADVDGA 228 ++ +++DG G E L V P++ASGG ++ ++ + ++G Sbjct: 180 VRRYIVTDVSKDGSLAGPGAELLDVVLAQTDRPVVASGGVASLADLVKLRSMVPSGLEGV 239 Query: 229 LAASVFHKQIINIGELKAYLATQ 251 + + + + ++ Sbjct: 240 VLGKALYVGNFSFEQALEIAGSR 262 >UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Methanopyrus kandleri RepID=HIS4_METKA Length = 242 Score = 168 bits (427), Expect = 1e-40, Method: Composition-based stats. Identities = 48/252 (19%), Positives = 102/252 (40%), Gaps = 14/252 (5%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGADELVFYDITASSDG 58 +A +IP +DV +G+ V+ V+ D V A +++E + D+ A+ G Sbjct: 1 MAFVVIPSVDVVEGKCVQLVEGDPERRTFESDDPVETAHQWSEF-FPWIHVVDVDAAR-G 58 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 + + R+ E +D V GGI+S E A +++ GAD++ + + A D +++ D Sbjct: 59 EGDNSDIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDDFSKIVD 118 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 I V + + N D ++ + A + Sbjct: 119 VCHDHGIEVFVALDVNE-------NHEVLVSGWKEDAGVTLEDAIERFNEV-ADGYLTTA 170 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQI 238 ++ +G G D + ++K +P++ +GG +++ A ++A G + + + Sbjct: 171 VHVEGKEMGIDEKVVEKSTGATDLPVLYAGGIASIKDVKRA-KEAGAYGVVIGTALYHGD 229 Query: 239 INIGELKAYLAT 250 I+ L + Sbjct: 230 IDPVALLDLMEE 241 Score = 47.5 bits (112), Expect = 5e-04, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 25/71 (35%), Gaps = 1/71 (1%) Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 G + + + ++ E + GG + E E + D + +V + ++ Sbjct: 58 GEGDNSDIIGRICEEVDAKVQVGGGIRSAERAEE-LIELGADRLIVGTVAFTDKDDFSKI 116 Query: 245 KAYLATQGVEI 255 G+E+ Sbjct: 117 VDVCHDHGIEV 127 >UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. AS9601 RepID=A2BSD9_PROMS Length = 254 Score = 166 bits (420), Expect = 8e-40, Method: Composition-based stats. Identities = 61/236 (25%), Positives = 121/236 (51%), Gaps = 6/236 (2%) Query: 1 MLA-KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDI-TASSDG 58 M R+I L + +++K +F+N++ +GD + + + + + DE+ Sbjct: 1 MKKHPRVILSLIIDSKRMIKRSKFKNYKYLGDPLNIIRIFNSKRVDEISIISCENYEKKD 60 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 +D ++ +++ P +GG++SLEDA K+ S G +KI I + +P +I ++A+ Sbjct: 61 INIDFEFLEKISGEAFCPLTYSGGVRSLEDADKLFSIGFEKIGIRNLLHTNPEVIKQIAE 120 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNM 178 ++G Q +V+ ID E + YT S + T+ L++++ + GAGE+VL Sbjct: 121 KYGSQSVVIFIDYK---ELNNNEIEIYTSYNSFFKSTKSSILEFIKNAESYGAGEVVLQS 177 Query: 179 MNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 + ++G G DL+ +K++ +P+I+S G + +AF DG +A+ F Sbjct: 178 ILREGQSKGLDLDIIKEITNKTILPIISSCGMRDLSDARKAF-SLGADGVMASKFF 232 >UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase HisF n=1 Tax=Sphingobacterium spiritivorum ATCC 33300 RepID=C2G0W0_9SPHI Length = 263 Score = 165 bits (419), Expect = 1e-39, Method: Composition-based stats. Identities = 79/256 (30%), Positives = 127/256 (49%), Gaps = 11/256 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGA----DELVFYDITASS 56 ML KR+I L DG ++ FR ++ GDI L K Y DELV +++ S Sbjct: 1 MLRKRVIFTLLYCDGFFMQSRNFRLQKV-GDINWLEKFYKFNKIAFSLDELVILNVSRKS 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + VSR+ E +P V GGI+SLEDA + GADKI +N+ +DP L+ + Sbjct: 60 KNQEEFGRTVSRLVEGTYMPVAVGGGIRSLEDAEMLFKSGADKIVLNTSLSSDPDLVKLI 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 ++G Q +V ID E+ + + E+ + +++ ++ GE+ L Sbjct: 120 VQKYGSQSVVASIDYLKKGESSEIFI------ENGSLNINEGFENYLSHLKDLNVGEVYL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 N M +DG GYD +K V+ + +VPLI +GGAG H EA +++ A A++F+ Sbjct: 174 NSMERDGTGFGYDFSLVKLVKSILNVPLIIAGGAGNEGHLKEALLHSEISAAATANLFNF 233 Query: 237 QIINIGELKAYLATQG 252 + + + +L G Sbjct: 234 IGDGLPKARFFLINSG 249 >UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3E3_9BURK Length = 251 Score = 164 bits (415), Expect = 3e-39, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 106/259 (40%), Gaps = 23/259 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIG---DIVPLAKRYAEEGADELVFY--DITASSDG 58 IIP + ++DG+ V D + LAK++A+ GAD L + AS+ Sbjct: 1 MWIIPSIYIQDGKCVHVSYGDKTSSSPFEIDPLDLAKKWADLGADRLHIVQLGLNASTQN 60 Query: 59 RVV---DKSWVSRVAEVID--IPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 + +S++ E + +P +AGGIK++ L G D + + S + DP + Sbjct: 61 ATSLSKNNEVLSKLIEEVSHYLPLQIAGGIKTMASIESYLDMGFDFVVVGSAGVKDPHFM 120 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 F +++G+D + +S ++VT+++ + Q + G Sbjct: 121 NDACSAF-NGQVILGLDAR----------DGKVVTDSWSKVTKFDAVTIAQRLTDEGIDS 169 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTME--HFLEAFRDADVDGALAA 231 I+ M DG +LE + VP++A G G + H ++ D VDG + Sbjct: 170 IIYTDMGPDGNMTEVNLEATLNFAKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDGIILG 229 Query: 232 SVFHKQIINIGELKAYLAT 250 + ++ E + + Sbjct: 230 KSLDLGVYSLQEAIDIVDS 248 >UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01ZU7_SOLUE Length = 227 Score = 163 bits (414), Expect = 4e-39, Method: Composition-based stats. Identities = 47/241 (19%), Positives = 105/241 (43%), Gaps = 19/241 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEIIGD-IVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 I+PC+D+ DG+VV+ +Q R + GD + +R+ G E+ D+ A+ G+ + + Sbjct: 2 IVPCIDLMDGKVVQLIQGREKALEGDSPDEMLRRF--AGFPEIQVIDLDAAL-GKGSNDT 58 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 V +A V GG+++L+ A +LS GA ++ + + A + + Sbjct: 59 LVKMLASKAVCR--VGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLDPAT 116 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGV 184 +V +D+ + T++ + + ++ + ++++G+ Sbjct: 117 TIVALDSK----------GGRIVVKGWQEATEFTAEEVLHSLEPY-CSGFLCTYVDKEGM 165 Query: 185 RNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGEL 244 G DL+ ++R + A+GG T+E +A ++ A + +++ EL Sbjct: 166 MQGTDLDWFARLRAATAHEITAAGGITTLEDI-KALLAMNIHTA-VGMAIYTGRLDLEEL 223 Query: 245 K 245 + Sbjct: 224 R 224 >UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Synechococcus sp. WH 8102 RepID=HIS62_SYNPX Length = 269 Score = 161 bits (409), Expect = 2e-38, Method: Composition-based stats. Identities = 63/240 (26%), Positives = 104/240 (43%), Gaps = 11/240 (4%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYA----EEGADELVFYDITASS 56 M KRII L DG F+ IGD L + Y DEL+ DI+ S Sbjct: 1 MSKKRIIFVLLYCDGFFCLSRNFKLQR-IGDFRWLQRNYNFNYSATFIDELIILDISRKS 59 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 + + ++E I +P GGI+S EDA + GADK+ +N+ + P + ++ Sbjct: 60 RDINKFATLLYNLSENIFVPITAGGGIRSFEDAKVLFENGADKVCLNTSLIQCPHVSEKI 119 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 + +G Q +V ID +D K+ ++ + Q+ + + + EI+L Sbjct: 120 SSVYGQQSLVASIDFKHDHGDFKFFID------NGLIEVQYNIQELISFLDPLPFCEILL 173 Query: 177 NMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHK 236 +++DG G+DL R+ P+I GGAG +H +E D A + + Sbjct: 174 QSVDRDGTGTGFDLTLANTFRDQLSKPIILLGGAGHSDHLVEGLLHQSTDAVATAHLLNF 233 >UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=60 Tax=Staphylococcus RepID=HIS4_STAAB Length = 234 Score = 160 bits (404), Expect = 6e-38, Method: Composition-based stats. Identities = 36/236 (15%), Positives = 83/236 (35%), Gaps = 16/236 (6%) Query: 4 KRIIPCLDVRDGQVVKGVQF--RNHEIIGDIVPLAKRYAEE--GADELVFYDITASSDGR 59 + P +D+ V+ + + E + + Y + + + D+ + Sbjct: 2 IELWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQH 61 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADR 119 + ++ + + V GGI++ + G + + + + D + +A Sbjct: 62 AREFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHT 121 Query: 120 FGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMM 179 F + I DA VN + T+ +V+++ G I+ + Sbjct: 122 FPGR-----IYFSVDAYGEDIKVNGW------EEDTELNLFSFVKQLSDIPLGGIIYTHI 170 Query: 180 NQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 +DG +G + E ++ + +P+IASGG + +V A+ H Sbjct: 171 AKDGKMSGPNFELTGQLVKATTIPVIASGGIRHQQDIQR-LASLNVHAAIIGKAAH 225 Score = 40.6 bits (94), Expect = 0.046, Method: Composition-based stats. Identities = 19/109 (17%), Positives = 39/109 (35%), Gaps = 12/109 (11%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEE---GADELVFYDITASSDGR-- 59 RI +D G+ +K V + ++ K+ ++ G + DG+ Sbjct: 125 RIYFSVDAY-GEDIK-VNGWEEDTELNLFSFVKQLSDIPLGGIIYTHI-----AKDGKMS 177 Query: 60 VVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALA 108 + ++ + IP +GGI+ +D ++ S I A Sbjct: 178 GPNFELTGQLVKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQ 226 >UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=Lactobacillus fermentum RepID=C0WXE8_LACFE Length = 188 Score = 159 bits (403), Expect = 7e-38, Method: Composition-based stats. Identities = 58/195 (29%), Positives = 102/195 (52%), Gaps = 7/195 (3%) Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 V +++ + +P V ++++ + +L GADK+ I++ ++ P I ++A FG Sbjct: 1 MLDMVEAISQQVFMPMTVVCNVRTVVEVRNLLLAGADKVGISTRSIMAPDFIPKVAQVFG 60 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 Q IV +D D T + V T+ + +W V + G GE+++N M++ Sbjct: 61 NQSIVAILDYHVDPRTNRKIVCT-------PGNTELDAYEWTLRVVELGVGELLVNSMDR 113 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINI 241 DG NG+D + + +P++ASGGAG+ F E F ++ V GA+AAS FH + I Sbjct: 114 DGTENGFDTAFYRDLTTTLTIPVVASGGAGSTVDFEEVFVNSGVTGAMAASAFHLDQMTI 173 Query: 242 GELKAYLATQGVEIR 256 E+K L +G+ +R Sbjct: 174 SEVKETLLEKGILVR 188 >UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E352 Length = 229 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 91/243 (37%), Gaps = 25/243 (10%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI--IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 I P +D+ +G+ V + +I GD V A+ ++ L D+ + G + Sbjct: 4 IYPAIDIYNGEAVSLENGKIEKIESFGDPVKFAQEFSSISGK-LHIVDLNGAFTGNPANT 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + + + + GG +++E S G D I I + +L D ++ ++++ Sbjct: 63 NLIKNIRKNVKSFMQAGGGYRTMESIEAGYSLGIDSIIIGTASL-DKKILEEVSEKHKNI 121 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 I + N Y T+ D+ V+ R A + +N DG Sbjct: 122 TISID------------AYNGYIKYNGWADGTEISYRDFYSMVKGR-ANRFIFTAINSDG 168 Query: 184 VRNGYDLEQLKKVREVCH-VPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 + ++ + + +GG +++ + + +GA+ + I I Sbjct: 169 TG------HISRIEKFWDEGYFMYAGGVNSIDDLKK-LENMGFNGAIIGKALYNGNIKIE 221 Query: 243 ELK 245 ELK Sbjct: 222 ELK 224 >UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PRW0_MALGO Length = 576 Score = 155 bits (392), Expect = 2e-36, Method: Composition-based stats. Identities = 89/376 (23%), Positives = 144/376 (38%), Gaps = 119/376 (31%) Query: 1 MLAKRIIPCLDVR---DGQVV--KGVQFR-------------------------NHEIIG 30 M +RI+ CLDVR DG +V KG + +G Sbjct: 200 MPTRRIVACLDVRSNDDGDLVVTKGESYNVRERQPAEGQAKSTADGTIRSGGKAQVRNMG 259 Query: 31 DIVPLAKRYAEEGADELVFYDITASSD---GRVVDKSWVSRVAEVIDIPFCVAGGIKSLE 87 V LA+RY EEGADE+ F +IT+ + G S ++ A I +P V GGI+ Sbjct: 260 KPVELAQRYYEEGADEIAFLNITSFRNWALGDQPMLSLLNVAAATIFVPLTVGGGIRDFT 319 Query: 88 D-----------AAKILSFGADKISINSPALADPTL------------------------ 112 D A GADK+SI S A+ Sbjct: 320 DPDGTFHPALEVAHAYFRAGADKVSIGSEAVYAVEQLLQRATELGDCTGDPCAAPAMALR 379 Query: 113 ----ITRLADRFGVQCIVVGIDTWYD---------------AETGKYHVNQY-------- 145 I ++A ++GVQ +VV +D + G + Sbjct: 380 GDTGIEQIAHKYGVQAVVVSVDPKRVYLSDQEIDGLSDEHSSGDGPVDARTHPHASSIVC 439 Query: 146 ------------------TGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNG 187 + + + + V++ GAGE+++N +++DG G Sbjct: 440 GQDERPETAGQSARWWYMCTVKGGRESRDIDVVQLARGVERLGAGELLINSIDRDGSYAG 499 Query: 188 YDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRD------ADVDGALAASVFHKQIINI 241 +D + + VR ++P+IAS GAG +HF + A ++ ALAA +FH++ ++I Sbjct: 500 FDEKLIDLVRGCVNIPVIASSGAGCADHFCDVLASRPAARGAPIEAALAAGIFHRREVSI 559 Query: 242 GELKAYLATQGVEIRI 257 ++K A G +R+ Sbjct: 560 MDVKKRCADAGYPVRM 575 >UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YI32_METS5 Length = 228 Score = 153 bits (387), Expect = 6e-36, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 92/238 (38%), Gaps = 18/238 (7%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +++P +D+ G VK V+ R ++GD + +A+ G + D+ A+ +G+ Sbjct: 1 MKVVPSIDISKGMAVKRVRGREGTGLVLGDPLKIAEELRNMGYTSVHLVDLDAA-EGKGD 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + RV + V GGI+ + LS GA K+ +++ A P R+ + Sbjct: 60 NVEVIERVMKDFS-EISVGGGIRDRSRLERFLSSGATKVVMSTLAFTKPDTFRRVVAGYE 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + +V K + + + + + V G ++ + Sbjct: 119 NRVLVSVDYCER-----KVLIKGW-------NESAMSFEEAISHVNSLGVRGVIFTYVCN 166 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +G RNG D E + + + +GG G+++ E A+ + ++ Sbjct: 167 EGTRNGIDPE-IGRYVNLVQGEKGYAGGIGSIQDLQE-LDKMGFHFAIVGMSLYAGVL 222 >UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_MYXXD Length = 238 Score = 152 bits (385), Expect = 9e-36, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 94/238 (39%), Gaps = 17/238 (7%) Query: 7 IPCLDVRDGQVVKGVQFR---NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IP +D+R+G V+ V + + + K++ G D+ A+ G+ + Sbjct: 4 IPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAAL-GKGSNA 62 Query: 64 SWVSRVAE-VIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + F V GG++ + +LS GA+ + + + A+ D + +A+RF Sbjct: 63 DAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPG 122 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + +VV D T + + + + + G +++ ++++ Sbjct: 123 R-VVVAADVKGR----------EVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKE 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 G +G DL +++V L ASGG TME + + ++ Sbjct: 172 GQLSGVDLPLMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVI-GMALYTGRLD 228 >UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit HisF2 n=3 Tax=Rhizobium RepID=Q7WYR2_RHIL3 Length = 251 Score = 152 bits (384), Expect = 1e-35, Method: Composition-based stats. Identities = 62/220 (28%), Positives = 102/220 (46%), Gaps = 11/220 (5%) Query: 2 LAKRIIPCLDVRDGQ-VVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRV 60 + KR+IP L V + +VK ++F +GD + + + E+ DE+ DI A+ GR Sbjct: 1 MRKRLIPVLLVDQKRRLVKTIEFGERTYVGDPFNVVRLFNEKEVDEICILDIDATRTGRG 60 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 D +V +A +P GGI L+ ++ G +K + A + L+ +A Sbjct: 61 PDLGFVRELATECFMPLAYGGGITELKQCEELNRSGVEKFVLGQGA-RNSQLVGAIAADM 119 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G Q +V +D D +G E +++ +Q G GEI+L Sbjct: 120 GSQALVACVDV--DGRGAAASCYASSGARQ-------EPIEFCLRLQDAGVGEIILQSKT 170 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAF 220 DG RNGYDLE ++ + +P++A GGAG + H +E Sbjct: 171 LDGTRNGYDLELIQSITRKLSIPVVALGGAGDVAHLMEGL 210 >UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Picrophilus torridus RepID=Q6KZD4_PICTO Length = 222 Score = 150 bits (379), Expect = 5e-35, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 95/250 (38%), Gaps = 33/250 (13%) Query: 6 IIPCLDVRDGQVVKGVQFR--NHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 + P +D+ +G+ V R ++ GD V A R+ E D L D+ + + + ++ Sbjct: 4 VYPAIDIYNGRAVFLENGRLERIKVYGDPVYYALRFQEY-FDFLHVIDLNGAIENKRKNR 62 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 + + + + V GG+++L D + FGA I + + + Sbjct: 63 DVIKNIIKEVKAKVQVGGGLRTLNDVIDVYDFGAYSAIIGTNIDIEVD-----------K 111 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 + + ID + D + +T + + + + ++ R + + DG Sbjct: 112 NVTLSIDVYKD----------RVANRGWLNITDNDPVSFYKMLKNR-FSRFIYTNIGSDG 160 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 + +K + + I +GG + +A ++ G + ++ I+ GE Sbjct: 161 TN---NSGIPEKFWD--NEYFIYAGGVSGINDVKKALKN-GFSGIIIGRALYENRIDPGE 214 Query: 244 LKAYLATQGV 253 LK +G+ Sbjct: 215 LK--CLQKGL 222 >UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Sulfolobus RepID=HIS4_SULSO Length = 232 Score = 148 bits (373), Expect = 2e-34, Method: Composition-based stats. Identities = 42/237 (17%), Positives = 98/237 (41%), Gaps = 15/237 (6%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 IIP +D+ G+ VK ++ ++G+ + LA + EG + D+ A+ +G + Sbjct: 3 EIIPSIDISFGKAVKRIRGVRGTGLVLGNPIELANKLYNEGYSRIHVVDLDAA-EGVGNN 61 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 + ++ + ++ V GGI+ +E A +++S + + ++ + L + G Sbjct: 62 EMYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGN 121 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 ++V ID +T + ++ + E +D +++V + I+L + + Sbjct: 122 NRVIVSIDY---DDTKRVLISGWKERS-------MEIIDGIKKVNELELLGIILTYVTNE 171 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 G G D +K ++ +GG + ++ D + F+ I Sbjct: 172 GTVKGIDYS-VKDYAKLIRGVKEYAGGVSSDSDI-TFLKNVGFDYIIVGMAFYLNKI 226 >UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NHA2_KYTSD Length = 470 Score = 147 bits (371), Expect = 4e-34, Method: Composition-based stats. Identities = 54/254 (21%), Positives = 89/254 (35%), Gaps = 21/254 (8%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 + R+ P +DVR G + Q + D + +GA+ L D+ + G Sbjct: 1 MPLRLWPAVDVRGG---RTAQVDPDSPLSDPQAAVDHWVAQGAERLHLVDLDRA-TGAGE 56 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 + + + R+ +P V+GGI S D + LS+GA ++ +S ADP G Sbjct: 57 NDALLERLVRRASVPVEVSGGILSPRDVERALSWGAVAVTTSSALWADPAAALEWLQGCG 116 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 + V + T + D ++ G VL Sbjct: 117 AEVQV------------GIDLVGDRVVARGTDLALGPVADLWPDLAGLGERRWVLASAAA 164 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDG-----ALAASVFHK 236 DG G DL L+ E LIASGG T + V G + + + Sbjct: 165 DGRMTGPDLAGLRAATEHLTGTLIASGGVSTTGDLVAVSSLRGVAGPAVGEVILGAALYA 224 Query: 237 QIINIGELKAYLAT 250 +++G + L Sbjct: 225 GAVDLGRAQRLLGE 238 >UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlorococcus marinus clone ASNC1363 RepID=Q1PLA2_PROMA Length = 268 Score = 146 bits (370), Expect = 5e-34, Method: Composition-based stats. Identities = 76/260 (29%), Positives = 120/260 (46%), Gaps = 16/260 (6%) Query: 3 AKRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYA----EEGADELVFYDITASSDG 58 KRII L + V FR IGD+ L K Y DEL+ D+T Sbjct: 4 KKRIIFTLLYNSNRFVLSRNFRLQT-IGDLDWLKKNYNFDNVAYHIDELLILDVTRGRKD 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLAD 118 V++++E I +P + GGI SLE A GADK+SINS L D +L+T++ Sbjct: 63 SEEFCKVVTQISENIFVPLTIGGGINSLEKAKLFFKSGADKVSINSSLL-DESLVTQIVK 121 Query: 119 RFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQW-ETLDWVQEVQKRGAGEIVLN 177 +G QC+V ID + +Y+V G + + + ++ E ++ GEI +N Sbjct: 122 NYGKQCLVGSIDVLK--KNEEYYVYSNNGTKLVSSLNKFFENKEFFNN-----IGEIYIN 174 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 +NQDG NG D+ + V VP I SGG G + +AF+ ++ A + + Sbjct: 175 SINQDGTGNGLDISLAEFVSAKSEVPFIISGGVGKITDIKDAFKYDFINAVSTAHLLNFI 234 Query: 238 IINIGELKAYLATQGVEIRI 257 ++ + + G +R+ Sbjct: 235 GDSLKKTRLICDECG--VRL 252 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 146 bits (368), Expect = 9e-34, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 95/242 (39%), Gaps = 27/242 (11%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII---GDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 +IP +D+ DG+ V+ Q I ++ L + ++ G E+ D+ A+ G+ + Sbjct: 2 LIPSIDLLDGKAVQLQQGDASRKIVEKDNLFELLEEFSLFG--EVAIIDLNAAL-GKGDN 58 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 K+ + ++ + V GGI++ E A + LS GA KI + + D + Sbjct: 59 KALIKQLIKKFSCR--VGGGIRNYETAREYLSSGAKKIILGTSCRED------FVKKLPR 110 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 ++ ID D + + + E+Q E + + ++ Sbjct: 111 SQLIFAIDAKGDDWV----------THGWQSSSDNKVAAMIDELQD-NCSEFLYTQVEKE 159 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIG 242 G+ G D E++++V + + + +GG ++ + + L + + + Sbjct: 160 GMMQGIDRERIEQVIKQSKIQVTVAGGITDLDDI-KFINKLGANSQL-GMSIYTGKLKLD 217 Query: 243 EL 244 E Sbjct: 218 EA 219 Score = 43.3 bits (101), Expect = 0.008, Method: Composition-based stats. Identities = 25/148 (16%), Positives = 48/148 (32%), Gaps = 3/148 (2%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 ++I +D + V + + + ++ L + + +D+ Sbjct: 112 QLIFAIDAKGDDWV--THGWQSSSDNKVAAMIDELQDNCSEFLYTQ-VEKEGMMQGIDRE 168 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQC 124 + +V + I VAGGI L+D I GA+ S L + Sbjct: 169 RIEQVIKQSKIQVTVAGGITDLDDIKFINKLGANSQLGMSIYTGKLKLDEAVMACLDFDK 228 Query: 125 IVVGIDTWYDAETGKYHVNQYTGDESRT 152 + D +TG + Y+ ES Sbjct: 229 APLIPTIVQDVDTGSVLMLAYSTPESLQ 256 >UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZ82_ACIFD Length = 246 Score = 145 bits (367), Expect = 1e-33, Method: Composition-based stats. Identities = 49/257 (19%), Positives = 92/257 (35%), Gaps = 21/257 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNH--EIIGDIVPLAKRYAEEGADELVFYDITASSD-GRV 60 ++ +D+ DG+ V+ Q R GD + + GA D+ + G Sbjct: 1 MELVVAVDLLDGEAVRLRQGRFDAPRRFGDPRRYVEGALDAGARWFHVVDLDRARTPGDR 60 Query: 61 VDKSWVS---RVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 + V + V GG+++ D A++L GA ++ + + L+ Sbjct: 61 RNADMVGDLIALVREAGGSVEVGGGVRTARDIAELLETGASRVVLGTA------LVEETL 114 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 D + +V +D E V + R L+ + RG +L Sbjct: 115 DELDPEHLVAALDYRRGDEGALEVV-----VSAWERSGGRRLLEASARLFARGVRTQLLT 169 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDAD----VDGALAASV 233 + +DG+ +G DL + + EV V +IASGG + + + V GA+ + Sbjct: 170 DVGRDGMASGPDLGTYQGLCEVVPVEVIASGGVASADDLAKLAAIRGARGAVWGAVVGTA 229 Query: 234 FHKQIINIGELKAYLAT 250 + E + Sbjct: 230 LLDGSLGFDEALSACRA 246 >UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9303 RepID=A2CB98_PROM3 Length = 266 Score = 143 bits (362), Expect = 4e-33, Method: Composition-based stats. Identities = 66/260 (25%), Positives = 111/260 (42%), Gaps = 13/260 (5%) Query: 1 MLAKRIIPCL--DVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEG----ADELVFYDITA 54 M KRII L D + + FR E+ GD L + Y DEL+ D++ Sbjct: 1 MPKKRIIFTLLYDSQSEHFLLSRNFRVQEV-GDYNWLKENYDFTNLSYYIDELLVIDVSR 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLIT 114 S + +++ +P GG+ SL+ A + GADK+ +N+ +P LI Sbjct: 60 KKRNSQRFCSMLKKLSSDCFLPIGAGGGLDSLDKAKMLFDSGADKLILNTSVYENPELIK 119 Query: 115 RLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEI 174 L +G Q I+ +D + E G + + + G + + + ++ + + GE+ Sbjct: 120 ALNKFYGQQAIIASVDIKKN-ELGIFDIYTHNGTKKASSLKDYQNI----ICKNEWIGEL 174 Query: 175 VLNMMNQDGVRNGYDLEQLKKVREV-CHVPLIASGGAGTMEHFLEAFRDADVDGALAASV 233 LN M +DG GYD LK + P+I +GGAG H +E VD A + Sbjct: 175 YLNSMERDGTGQGYDFNMLKSFTNLNKKHPIILAGGAGKTSHIVEGLLTDGVDACATAHL 234 Query: 234 FHKQIINIGELKAYLATQGV 253 F+ + + + G+ Sbjct: 235 FNFIGDKLAKTRCIAKANGI 254 >UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oceani RepID=Q3JEF8_NITOC Length = 235 Score = 142 bits (358), Expect = 1e-32, Method: Composition-based stats. Identities = 44/259 (16%), Positives = 92/259 (35%), Gaps = 38/259 (14%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---------GDIVPL-AKRYAEEGADELVFYDIT 53 +++P LD+ G VV + + + + A +L D+ Sbjct: 1 MQLLPVLDLWGGVVVHARGGQRDSYLPLNSPFAPNSSPLQVVAGLLQWCRFQQLYIADLN 60 Query: 54 ASSDGRVVDKSWVSRVAEVI-DIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 + G + ++ +A D+ V GG E A++ + G + + + L D Sbjct: 61 -AIMGDGNNHFMIAAIARSYPDLELWVDGGTARHEAVAQLFALGVARPVVGTETLPDLES 119 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 + + + + +D A G +++ + G Sbjct: 120 W-QALQSSWPEQLALSMDHRRGAFLGPAGLDRQP---------------------ELWPG 157 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVC---HVPLIASGGAGTMEHFLEAFRDADVDGAL 229 ++ ++Q G + G D L+++ + + L+A+GG +E + V+G L Sbjct: 158 TVIAMSLDQIGSQQGPDWSLLERLGQRSLRKRISLLAAGGVRCLEDLKQ-LAAWGVEGVL 216 Query: 230 AASVFHKQIINIGELKAYL 248 AS H +N EL+ L Sbjct: 217 LASALHDGSLNPAELQQML 235 >UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermoproteaceae RepID=HIS4_PYRAE Length = 229 Score = 141 bits (357), Expect = 2e-32, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 95/238 (39%), Gaps = 19/238 (7%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEII--GDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP +D+ G+ VK ++ + I GD + LA R+ + A + D+ + G +V+ Sbjct: 2 IIPSIDIEGGRAVKRIRGQRGNYIFQGDPLELAARFRK--APLVHVVDLDGAEAGGLVNI 59 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 S +S++AE+++ + GG++SLE + LS + S + L R A+ + + Sbjct: 60 SVISKIAEILEGRCELGGGLRSLEAVERALSL-CQYAVVGSLPFKNWPLFRRAAELYRDR 118 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA-GEIVLNMMNQD 182 V D G+ V + + + V+ +++ G +++ + + Sbjct: 119 LAV-----SLDYRGGEVLVGGWREKAA-------SIAEAVRRLEEAGPYAAVIVTSVEVE 166 Query: 183 GVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 G G + K + + +GG A DG + + + Sbjct: 167 GTGGGVKADIDVKSLKRIARRVFYAGGVRDCNDVERA-YALGFDGVIVGYALYAGDLK 223 >UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepID=Q4JIN2_9BACT Length = 248 Score = 140 bits (353), Expect = 5e-32, Method: Composition-based stats. Identities = 48/249 (19%), Positives = 85/249 (34%), Gaps = 26/249 (10%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI------------IGDIVPLAKRYAE-EGADELVFY 50 R+I +D+ G+ V R + +GD LA+ Y E G EL Sbjct: 1 MRVIGVIDLAAGRAVHARGGRRTDYAPVRLSGAAAAHVGDPCALARTYLETRGLTELYVA 60 Query: 51 DITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP 110 D+ + G + + + + P + G+ S+ A L GA + + L Sbjct: 61 DLD-AIGGGPSQDAAIGALIR-LGAPLWLDSGVHSVPRARHALGLGASFVVVGLETLPSY 118 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 +++ + G + + +D + + G Sbjct: 119 DVLSEICADVGSERVAFSLDLR----------DGLPITAHADVAAGRSVEQIAARAVEAG 168 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALA 230 G I++ + + G+ G DL + +R V L+A GG E + A DG L Sbjct: 169 VGAIIVIDVARVGMGEGVDLALISSLRSVAPAVLLAGGGVRGSEDL-ASLAHAGCDGVLV 227 Query: 231 ASVFHKQII 239 A+ H I Sbjct: 228 ATALHDGRI 236 >UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanococcales RepID=Y703_METJA Length = 226 Score = 139 bits (352), Expect = 7e-32, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 97/255 (38%), Gaps = 45/255 (17%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYDITA 54 +IIP +D++D V G E + + +AK Y E GA + D+ Sbjct: 1 MKIIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLN- 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED---AAKILSFGADKISINSPALADPT 111 G + + + I V G+KS ED K+L+ D+ + + L D Sbjct: 60 FIMGNGDNFDIIKEID---FINKIVDIGVKSREDLETIKKVLNKD-DRAIVATETLKDIE 115 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 L+ + IVV +D + + E L V++ Sbjct: 116 LLKE-------KDIVVSLDFKNG---------------NLLNYSLDEILSCVRDDTP--- 150 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 +++ ++ G + G + E +K V + + P+ GG ME E + VD L A Sbjct: 151 --LIILDISSVGTQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDL-ELCYNLGVDAVLIA 207 Query: 232 SVFHKQIINIGELKA 246 + HK ++++ E+ Sbjct: 208 TAIHKGVLDLEEIIN 222 Score = 57.9 bits (139), Expect = 3e-07, Method: Composition-based stats. Identities = 19/76 (25%), Positives = 34/76 (44%) Query: 47 LVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPA 106 L+ DI++ R V+ + V + + P V GGIK +ED + G D + I + Sbjct: 151 LIILDISSVGTQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAI 210 Query: 107 LADPTLITRLADRFGV 122 + + ++FG Sbjct: 211 HKGVLDLEEIINKFGD 226 >UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Sulfolobus acidocaldarius RepID=Q4J8J0_SULAC Length = 226 Score = 138 bits (347), Expect = 2e-31, Method: Composition-based stats. Identities = 43/238 (18%), Positives = 102/238 (42%), Gaps = 20/238 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHE--IIGDIVPLAKRYAEEGADELVFYDITASSDGRVV 61 +++P +D+ + VK ++ + I+GD + +AK EG D + D+ A+ +G Sbjct: 1 MKVMPSIDISNKVAVKRIRGKGGSGIILGDPLKIAKEIISEGYDAIHIVDLDAA-EGLGD 59 Query: 62 DKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFG 121 +K + ++ + V GG++ LE A IL + I +++ + + ++ G Sbjct: 60 NKDIIKQICTLGFSWTQVGGGVRKLEIAKDILEY-CSSIVVSTLPITNRQEYDKIISGVG 118 Query: 122 VQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQ 181 V + + ID + G + + + V ++ +G ++ + Sbjct: 119 VDKVFLSIDY---DDNGYVLIKGWKEKSVK-----------VSDLLDLESGGVIFTYIPN 164 Query: 182 DGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQII 239 +G + G D ++ V+ V + +GG G+++ L+ + D ++ F+ + Sbjct: 165 EGTKGGIDNNVVEYVKSVKKIK-EYAGGIGSLDDLLK-LKSFGFDYSIIGMSFYNGTL 220 >UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococcus sp. FS406-22 RepID=D1SND3_9EURY Length = 237 Score = 137 bits (346), Expect = 3e-31, Method: Composition-based stats. Identities = 52/259 (20%), Positives = 96/259 (37%), Gaps = 37/259 (14%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYDITA 54 +IIP +D+ + V G E + + +A Y E GA+ + D+ Sbjct: 1 MQIIPVIDLMNKIAVHGKSGNRDEYKPLKSVICNSPNPIDVAMAYKERGAETIYIADLN- 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGA--DKISINSPALADPTL 112 G + + + + V G+K ED I DK + + L D L Sbjct: 60 FIMGNGDNFEVIKEID---FVNKIVDIGVKRREDLENIKKILNKDDKAIVATETLKDIEL 116 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 + + IVV +D + Y+ D + V + L + Sbjct: 117 LKE-------KDIVVSLDFKNGELLLDKNFKDYSLDGILSYVREDTPLTIL--------- 160 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 ++ G + G ++E +K V + + P+ GG M+ E + VDG L A+ Sbjct: 161 -----DISSVGTQRGINVELIKYVLDKTNNPVYVGGGIKGMDDL-ELCYNLGVDGVLIAT 214 Query: 233 VFHKQIINIGELKAYLATQ 251 HK I+++ E+ + + + Sbjct: 215 AIHKGILDLEEIISKFSDK 233 >UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Acidobacteria RepID=Q1IKB1_ACIBL Length = 228 Score = 137 bits (346), Expect = 3e-31, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 94/242 (38%), Gaps = 23/242 (9%) Query: 6 IIPCLDVRDGQVVKGVQFRNHEI-IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKS 64 +IP +D+ G++V+ VQ D +R+ G + D+ A+ + ++ Sbjct: 2 LIPSIDLMGGKIVQLVQGEKKAFETTDFDAWCERF--AGFPMVQLIDLDAAKR-QGDNRE 58 Query: 65 WVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP----TLITRLADRF 120 ++ + + +P V GG++ + A ++L+ GA ++ + S + D LA+R Sbjct: 59 LIANIV--LRLPCQVGGGVRDADVAERLLAIGAKRVIVGSSYIRDGRVDVDFARGLAERC 116 Query: 121 GVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMN 180 G ++ ID+ + + + + G + ++ Sbjct: 117 GTDRVIAAIDSR----------EGFVAVRGWQESVPITAGEMIAALTPY-VGGFLYTHVD 165 Query: 181 QDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 +G+ G+ + +++R + LIA+GG + E E VD + + Sbjct: 166 TEGLLVGFPTDIARRLRTLTEKQLIAAGGIRSQEEIDE-LDGIGVDAV-VGMAIYTGKLV 223 Query: 241 IG 242 + Sbjct: 224 VK 225 >UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41F9C Length = 231 Score = 137 bits (345), Expect = 4e-31, Method: Composition-based stats. Identities = 45/251 (17%), Positives = 88/251 (35%), Gaps = 31/251 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYD 51 ML IIP +D+ + V G D + +A GA E+ D Sbjct: 1 ML--EIIPVIDLMNSVAVSGKSGNRETYTPLQTIYASSSDPLEIALSLKSAGAKEMYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + + + V V +P + G+ LE +L F A KI + + L Sbjct: 59 LDFIERNGNNNIFKIKEVNSV--LPVILDVGVDKLETFEFLLEF-AYKIIVATETLESIE 115 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + ++ +++ + I+V +D + E + + + + +++ Sbjct: 116 ELGKIFEKYPKERIIVSVDVKNN--------------ELYAKNMDLDLEGFKEVLRRIDP 161 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 EI+L ++ G G++ L+ E +I GG + + AL Sbjct: 162 NEIILLDISSVGTEGGFNKPLLESFEEFKD-KIILGGGIT--PDEISQLDALGIRKALVG 218 Query: 232 SVFHKQIINIG 242 + HK I + Sbjct: 219 TALHKGQIRLN 229 >UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M908_CALMQ Length = 228 Score = 134 bits (337), Expect = 3e-30, Method: Composition-based stats. Identities = 41/241 (17%), Positives = 100/241 (41%), Gaps = 28/241 (11%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHE-----IIGDIVPLAKRYAEEGADELVFYDITASS 56 +++ +IP +D+ +G VVK V+ + + + L K Y + D+ + Sbjct: 1 MSRLVIPSIDLSNGLVVKRVRGVKGSELVKLNLNEALSLVKDY-----PFIHVVDLNGAE 55 Query: 57 DGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRL 116 G+ ++ ++++ ++ V GG++ +EDA +L + ++ + + A+ +P L+ + Sbjct: 56 LGKPINVDSIAKIGATVNGRCEVGGGVRVIEDAELLLKY-CSRVVLGTVAVENPALLLNM 114 Query: 117 ADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVL 176 +R GV + V +DT + + R + L + ++ Sbjct: 115 INRLGVDKVAVSLDT----DGEWLMTRGWGVRARRI----MDALSNLPR-----VSAVIY 161 Query: 177 NMMNQDGVRNGY--DLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVF 234 ++ +G G + E +K++R++ + +GG + E DG + Sbjct: 162 TNVSVEGTGMGPRVNGELVKRLRDI-GKEVYYAGGVSSCSDV-EYLWGLGFDGVIIGYAL 219 Query: 235 H 235 + Sbjct: 220 Y 220 >UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methanobrevibacter smithii RepID=A5UNR3_METS3 Length = 229 Score = 134 bits (337), Expect = 3e-30, Method: Composition-based stats. Identities = 48/252 (19%), Positives = 95/252 (37%), Gaps = 32/252 (12%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYD 51 M+ K +P LD++D V G + V +A + GADEL D Sbjct: 1 MIKK--VPVLDLKDNIAVSGKSGLRDTYTPLQTVFAPSANPVDIANGLSINGADELYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + +G + V V +P + G+K E L + A KI + + + Sbjct: 59 LD-LIEGNGHNIHDVKMV--NSILPVMLDAGVKDFESFTFFLDY-AYKIIVPTETIKSIG 114 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 I ++ +++ + IVV +D + E ++ ++ + +++ Sbjct: 115 EIKKIFEKYPKERIVVSVDVKDN--------------ELYSKNLNISLAEFKEILEELDP 160 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 EI+L + G + GY+ E L +++ LI +GG + D + L Sbjct: 161 DEIILLDITGVGTQKGYNQELLDDFKDLKD-KLIIAGGLNNKS--VSELEDMGIKKVLVG 217 Query: 232 SVFHKQIINIGE 243 + H + + + Sbjct: 218 TALHSGEMKLLD 229 >UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C0W3_9PLAN Length = 247 Score = 133 bits (336), Expect = 4e-30, Method: Composition-based stats. Identities = 39/248 (15%), Positives = 78/248 (31%), Gaps = 22/248 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEE-GADELVFYDIT 53 +IIP LD+ + +V+G+ + + +A+ +E G E D+ Sbjct: 1 MKIIPVLDILNQTIVRGIAGQRETYQPIQSGLTHSSQPLDIAQALQDEFGFSEFYVADLD 60 Query: 54 ASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 A R+ + + + + G+ D+ + I L P + Sbjct: 61 AILQQRL-NLQMYQCLLDAGFTFL-LDCGLHFAGDSQPLSKMKGITIVAGLETLESPQEL 118 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 +L +G V +D + L+ + ++G + Sbjct: 119 KQLVQNWGAASTVFSLDLKQGKPV-------RNSSSDNPYAAIDDPLEIAELSLQQGVNQ 171 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREV--CHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 ++L + G G E L + + LI GG +++ D L A Sbjct: 172 MILLDLANVGTGQGTGTEALCRTLRSHHPDLRLITGGGIHSIDDLQTQAEQ-GADAVLVA 230 Query: 232 SVFHKQII 239 S H + Sbjct: 231 SALHDGRL 238 >UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=1 Tax=Cyanothece sp. PCC 7425 RepID=B8HVG9_CYAP4 Length = 226 Score = 133 bits (336), Expect = 5e-30, Method: Composition-based stats. Identities = 44/232 (18%), Positives = 96/232 (41%), Gaps = 19/232 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDK 63 IIP L + +G Q + D V +A+++A +GA L D + G +++ Sbjct: 1 MEIIPALKIMEGFCCHHRQ--PYRFNCDPVAMAEQWANQGATRLHLIDCNGVTTGAMLNL 58 Query: 64 SWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQ 123 ++ + + + +P V G I S + + G D++ ++ ++ L+ L + F + Sbjct: 59 PTIAAIVQQVKVPVQVEGTIYSRAQIETLFAIGVDRVVVD-GSIGWSELVADLCEHFSGK 117 Query: 124 CIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDG 183 +V +A G+ + +T + + GA I+ + + G Sbjct: 118 IMV-----NLEAYDGRVACSG--------ELTGLLATTLAERAEAVGAAGIIYTDIARQG 164 Query: 184 VRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFH 235 +L+ LK + + ++P+IA GGA ++ L F + + + + Sbjct: 165 SGI-INLKALKHLADRVNLPIIAGGGASSIAELLRLFNPSTPQ--IVGMMVY 213 >UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales RepID=C9RDL3_METVM Length = 229 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 48/256 (18%), Positives = 97/256 (37%), Gaps = 45/256 (17%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYDITA 54 IIP +D++ V G + D + LAK Y E+G++ + D+ Sbjct: 1 MHIIPVIDIKGNIAVHGKSGMRSKYQPLKSVICETSDPICLAKSYKEKGSEMVYIADLD- 59 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSF--GADKISINSPALADPTL 112 + G + + + + I V GIK+ ED ++ + DK I + L D L Sbjct: 60 AICGEGDNFNLIKNID---FINKIVDAGIKTREDLERVREYLNKNDKAIIATETLIDKEL 116 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 I+ + I+V +D D T E L V++ Sbjct: 117 ISE-------KNIIVSLDFK---------------DGKLLNYTVEEVLGLVRKDTP---- 150 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREV--CHVPLIASGGAGTMEHFLEAFRDADVDGALA 230 +++ ++ G G +++ + + ++ P+ GG + + + +DG L Sbjct: 151 -LIILDISSVGTGRGINMKLINMILKLNKGKNPIYVGGGIRDITDIEKC-YNLGIDGVLV 208 Query: 231 ASVFHKQIINIGELKA 246 + H+ +I++ E+ Sbjct: 209 GTAIHRGVIDLEEVIK 224 Score = 52.5 bits (125), Expect = 1e-05, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 52/120 (43%), Gaps = 16/120 (13%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVPLAKRYAEEGADE-LVFYDITASSDGRVVD 62 K II LD +DG K + + E++G L ++ D L+ DI++ GR ++ Sbjct: 120 KNIIVSLDFKDG---KLLNYTVEEVLG----LVRK------DTPLIILDISSVGTGRGIN 166 Query: 63 KSWVSRVAE--VIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRF 120 ++ + + P V GGI+ + D K + G D + + + + + +F Sbjct: 167 MKLINMILKLNKGKNPIYVGGGIRDITDIEKCYNLGIDGVLVGTAIHRGVIDLEEVIKKF 226 >UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole carboxamide isomerase family protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C36C9 Length = 235 Score = 127 bits (320), Expect = 3e-28, Method: Composition-based stats. Identities = 42/242 (17%), Positives = 75/242 (30%), Gaps = 23/242 (9%) Query: 13 RDGQVVKGVQFRNHEI--IGDIV-------PLAKRY-AEEGADELVFYDITASSDGRVVD 62 +G VV+ V + + +A+ GA EL D+ + G Sbjct: 1 MNGVVVRAVGGDRKNYRPVRSPLTPSTVPTDIAQALLRSVGAGELYVADLD-AITGSARV 59 Query: 63 KSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGV 122 V + E +P + G D + + P ++ Sbjct: 60 TPSVEALMEACAVPVWLDAG-TGRRDVLDWPPHQNLRPVVGFETCRVPEVLAEALLEPRQ 118 Query: 123 QCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQD 182 + + +D G + GD + L + V G +++ + + Sbjct: 119 RPVAFSLDLRNGQLLGNWRAWGLAGDR--------DALALTRRVVDMGVRTLIVLDLARV 170 Query: 183 GVRNGYDLEQLKKV--REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIIN 240 G G ++L +V E + LIA GG T E A G L AS H+ + Sbjct: 171 GTGTGAGTDELVRVIRAEFPDLDLIAGGGVRTWSDV-ERLGKAGATGVLVASALHEGTLV 229 Query: 241 IG 242 + Sbjct: 230 LP 231 Score = 54.5 bits (130), Expect = 3e-06, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 41/108 (37%), Gaps = 12/108 (11%) Query: 8 PCLDVRDGQVV-----KGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVD 62 LD+R+GQ++ G+ D + L +R + G L+ D+ G Sbjct: 123 FSLDLRNGQLLGNWRAWGLAGDR-----DALALTRRVVDMGVRTLIVLDLARVGTGTGAG 177 Query: 63 KSWVSRVAEV--IDIPFCVAGGIKSLEDAAKILSFGADKISINSPALA 108 + RV D+ GG+++ D ++ GA + + S Sbjct: 178 TDELVRVIRAEFPDLDLIAGGGVRTWSDVERLGKAGATGVLVASALHE 225 >UniRef50_Q1NTJ9 Histidine biosynthesis n=1 Tax=delta proteobacterium MLMS-1 RepID=Q1NTJ9_9DELT Length = 186 Score = 126 bits (316), Expect = 9e-28, Method: Composition-based stats. Identities = 43/123 (34%), Positives = 68/123 (55%) Query: 135 AETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLK 194 G+ + + + ++ GAGEI+LN +++DG +G+DLE +K Sbjct: 62 GPNGEKYCWYQCTVKGGREGRDLDAATLAVACEELGAGEILLNCIDKDGTNSGFDLELVK 121 Query: 195 KVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGELKAYLATQGVE 254 V+E +P+IAS GAG EHF E F D ALAA +FH++ + I E+K +L G+E Sbjct: 122 MVKEAVTIPVIASSGAGKPEHFSEVFTVTGADAALAAGIFHRREVAISEVKEHLQRHGIE 181 Query: 255 IRI 257 +R+ Sbjct: 182 VRL 184 >UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V5Z6_9AQUI Length = 119 Score = 125 bits (315), Expect = 1e-27, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 60/117 (51%), Gaps = 3/117 (2%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRN---HEIIGDIVPLAKRYAEEGADELVFYDITASSDG 58 L + IIP +D+++G+ V+ + + V +AKR+ E+GA L D+ + +G Sbjct: 3 LKEFIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHIVDLDGAFEG 62 Query: 59 RVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITR 115 + V ++ + +++P GG+++ E K++ G +++ I S A D L + Sbjct: 63 IPKNYKIVEQIVKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDKELFEK 119 Score = 49.1 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 48/105 (45%), Gaps = 5/105 (4%) Query: 141 HVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGY--DLEQLKKVRE 198 V Y GD + +V ++ + +++GA L++++ DG G + + ++++ + Sbjct: 18 AVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKH--LHIVDLDGAFEGIPKNYKIVEQIVK 75 Query: 199 VCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQIINIGE 243 +VP+ GG T E + + V+ + S+ ++ + Sbjct: 76 SVNVPIEFGGGLRTYEAVKKMI-EIGVERVVIGSLAYQDKELFEK 119 >UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=O26765_METTH Length = 227 Score = 125 bits (315), Expect = 1e-27, Method: Composition-based stats. Identities = 49/246 (19%), Positives = 88/246 (35%), Gaps = 33/246 (13%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAEEGADELVFYD 51 ML IIP +D+ DG V G + D V +A GA + D Sbjct: 1 ML--EIIPVIDLMDGIAVSGKSGEREKYRPLESVYSPSPDPVNIALSLRAAGARSIYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + + +G + V RV V +P + G++ LE +L F A ++ + + L Sbjct: 59 LD-AIEGTGSNLEAVRRVNHV--LPVILDAGVRDLETFHFMLEF-ASRVVVATETLESTE 114 Query: 112 LITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGA 171 + + + + VV +D + H + E D + + Sbjct: 115 ELEEILRNYPPERTVVSVDVK----DMRLHSR-------NLEIGLEELRDLLMGYEV--- 160 Query: 172 GEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 +I+L + G +G++ E L+ R + +I GG + + V AL Sbjct: 161 -DIILLDIGSVGTSSGFNRELLELFRPLIE-RVIPGGGV--LPEEIPELEAMGVRAALVG 216 Query: 232 SVFHKQ 237 H+ Sbjct: 217 RALHEG 222 >UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9301 RepID=A3PE78_PROM0 Length = 222 Score = 121 bits (304), Expect = 2e-26, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 100/213 (46%), Gaps = 12/213 (5%) Query: 45 DELVFYDITASSDGRVVDKSW---VSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKIS 101 DE++ +++ + + + +S + +P + G I+S+E+A ++ +FGADKI Sbjct: 15 DEILIINLSEKNWEEAYNNKFFNDISLLLSKTFLPITIGGKIRSIENAKELFNFGADKIL 74 Query: 102 INSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLD 161 I+ D L+ + D +GVQ IVV D +++ +N S + + + Sbjct: 75 ISRAFFQDQNLLKEIRDLYGVQSIVVQFD--INSQNYDIFINSSLEKVSNLKKIVYSLNE 132 Query: 162 WVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFR 221 K GE+++N +++DG G++ E L + ++ ++PLIASGG G+ H E + Sbjct: 133 ------KNLMGELIINQIDRDGTGFGHNTEYLNAIPKL-NMPLIASGGFGSSIHMAECLK 185 Query: 222 DADVDGALAASVFHKQIINIGELKAYLATQGVE 254 + +++ + E + L E Sbjct: 186 FDSISAVATSNLLNFIGDAFSEARQELRKMNFE 218 >UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEW9_METST Length = 239 Score = 121 bits (304), Expect = 3e-26, Method: Composition-based stats. Identities = 36/250 (14%), Positives = 87/250 (34%), Gaps = 29/250 (11%) Query: 1 MLAKRIIPCLDVRDGQVVKGVQFRNHEII-------GDIVPLAKRYAEEGADELVFYDIT 53 M+ IIP +D+ + V G R + + +A E+GA + D+ Sbjct: 1 MIFM-IIPVIDIMHNECVSGKSGRRSTYKKLRSIYGDNPLDIATALKEDGAQLIYIADLD 59 Query: 54 ASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 + + IP + GI S+ED + + + + I Sbjct: 60 KIERIDDNNN---IISSINNIIPVMLDNGISSIEDIENNKNI-CSYNILATETMTSLDNI 115 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 + ++ +VV ID + E + D + + K Sbjct: 116 EEIFKKYDSNKLVVSIDIKNN--------------ELLVNNKDIDLEDVIYLINKYKPKY 161 Query: 174 IVLNMMNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 ++ ++ G + G + ++++ +++ H +GG + +E + +++ L + Sbjct: 162 TIILNISYVGTKKGVNTNIIEEITKKIPHTKCCIAGGIRNSD--IETYTKKNINNFLIGT 219 Query: 233 VFHKQIINIG 242 + H+ ++ Sbjct: 220 LLHEGNLSYK 229 >UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobiales RepID=C6QGP7_9RHIZ Length = 235 Score = 120 bits (301), Expect = 5e-26, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 88/259 (33%), Gaps = 40/259 (15%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAE-EGADELVFYDIT 53 IIP +DV G+VV+ +Q + + +A+ D+ Sbjct: 1 MDIIPVIDVSRGKVVRAIQGKRAAYLPIETPLAATSEPGDVARGLRSLYPFRRAYVADLD 60 Query: 54 ASSDGRVVDKSWVSRVAEV---IDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADP 110 +GR + V +++ ++ G +S A +L+ + + S +L Sbjct: 61 G-IEGRGRNTHLVPELSQALPNTELWIDAGTGSRSA--ARAVLAAPVATLVVGSESLESV 117 Query: 111 TLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRG 170 ++ + V+ +D D G + + Sbjct: 118 RAWHEISAEAPGRT-VLSLDFRGDEFMGP---------------------EALLADAALW 155 Query: 171 AGEIVLNMMNQDGVRNGYDLEQLKKVREVC-HVPLIASGGAGTMEHFLEAFRDADVDGAL 229 +++ +++ G ++ L+ + + A+GG ++E A GAL Sbjct: 156 PTRVIVMTLDRIASEGGPNIALLETIAARAGGRRVYAAGGIRSLEDLAR-IGKAGAAGAL 214 Query: 230 AASVFHKQIINIGELKAYL 248 AS+ H Q I+ G+LK Sbjct: 215 VASILHAQKISAGDLKEIA 233 >UniRef50_Q603E0 Putative HisA/HisF family protein n=1 Tax=Methylococcus capsulatus RepID=Q603E0_METCA Length = 227 Score = 119 bits (299), Expect = 8e-26, Method: Composition-based stats. Identities = 44/252 (17%), Positives = 73/252 (28%), Gaps = 41/252 (16%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII---------GDIVPLAKRYAE-EGADELVFYDIT 53 +IIP LD+ G+VV V+ R D + + + D D+ Sbjct: 1 MKIIPVLDLMQGRVVHAVKGRRENYRPLSSPLCPDADPRAVVEAFRNLYRFDTFYIADLD 60 Query: 54 ASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 + G ++ + D L G P Sbjct: 61 -ALMGLGCQNELIAALRTAFP-------------DIVFWLDRGL------------PEAG 94 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 D GV ++ + + T + + Q Sbjct: 95 EAALD--GVVPVIGSESLPTVDRLQRMTTRDWILSLDFFDGTLKGCSRLLAQPQCWPERV 152 Query: 174 IVLNMMNQDGVRNGYDLEQLKKVREVCHVP-LIASGGAGTMEHFLEAFRDADVDGALAAS 232 IV+ +N+ G +G DL+ L +VR + LIA+GG E + L AS Sbjct: 153 IVMT-LNRVGSFDGPDLDLLDRVRRLTPHRALIAAGGVRDAGDL-EILERRGIHAVLVAS 210 Query: 233 VFHKQIINIGEL 244 H + + L Sbjct: 211 ALHSGSLELSRL 222 >UniRef50_Q2FS89 Histidine biosynthesis n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FS89_METHJ Length = 226 Score = 119 bits (299), Expect = 8e-26, Method: Composition-based stats. Identities = 40/249 (16%), Positives = 71/249 (28%), Gaps = 36/249 (14%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEII------GDIVPLAKRYAEEGADELVFYDITASSD 57 + D++ G++V G + D + + L D+ Sbjct: 1 MDLYLATDLKSGKIVHGKSGMRDRYVPVTSLHADTAEPIRFIEQMKPRFLYIADLDR-IC 59 Query: 58 GRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLA 117 G + +AE + +L G + Sbjct: 60 GTGDHDPLIPELAERTE---------------RILLDRGCKGPY-------------DML 91 Query: 118 DRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLN 177 D FGV IV V + + ++ + ++L Sbjct: 92 DIFGVSMIVGTETAADTLAQFTKGVLSVDIKNDLVIPWNIDPVTFLSTCNRYRFEMVILL 151 Query: 178 MMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGALAASVFHKQ 237 + + G G D E L + REV PL+ GG + E A DGA+ A+ H Sbjct: 152 DIGRVGTGRGLDKEMLSQFREVYTGPLLWGGGVSSEEDL-ALLEKAGFDGAIIATAVHSG 210 Query: 238 IINIGELKA 246 I + ++ Sbjct: 211 KIPVEYIRR 219 >UniRef50_D1JF95 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=uncultured archaeon RepID=D1JF95_9ARCH Length = 238 Score = 119 bits (298), Expect = 1e-25, Method: Composition-based stats. Identities = 40/251 (15%), Positives = 87/251 (34%), Gaps = 31/251 (12%) Query: 2 LAKRIIPCLDVRDGQVVKGVQFRNHEII-----------GDIVPLAKRYAEEGADELVFY 50 + R+I +D+ DG VV + + + D A+ E+ Sbjct: 1 MDFRLIFVMDLLDGVVVHAKRGEREKYVPIHRFSSIVTSSDP---ARVIETIKPKEVYIA 57 Query: 51 DITASSDGRVVDKSWVSRVA-EVIDIPFCVAGGIKSLEDAAKILSFG-ADKISINSPALA 108 D+ ++ + + D+ + G+K +ED + + ADK + + + Sbjct: 58 DLNR-LLSTGNNRPILKDLRTRNRDLRIMLDYGVKGMEDLKEAVDAEMADKFVLGTETI- 115 Query: 109 DPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQK 168 L+ + + + + + L ++E+ K Sbjct: 116 SIELLEEASKS------------DIITDISISIDLFNNEVLTSDTRMKIDPLRLIKELNK 163 Query: 169 RGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGA 228 ++++ +N+ G ++G D E L + E+ ++ GG E + + V GA Sbjct: 164 FPVRDVIVLELNRVGTKSGIDFEFLARAVELSEHDILCGGGVRNCEDVHKM-AEIGVKGA 222 Query: 229 LAASVFHKQII 239 L A+ H I Sbjct: 223 LVATAIHDGGI 233 >UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TG14_METVO Length = 148 Score = 117 bits (294), Expect = 4e-25, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 62/117 (52%), Gaps = 4/117 (3%) Query: 29 IGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLED 88 + +AK + E GA+ L D+ + DG V+ V ++ + +P + GGI+++ED Sbjct: 3 YDNPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIED 62 Query: 89 AAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQY 145 ++++ G +++ I + A+ +P + +LA + G + I+V +D GK + + Sbjct: 63 VEELVNLGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVALDAK----DGKVVIKGW 115 Score = 49.9 bits (118), Expect = 8e-05, Method: Composition-based stats. Identities = 15/100 (15%), Positives = 41/100 (41%), Gaps = 1/100 (1%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL 217 + + + GA + L ++ +L +KK+ + VP+ GG T+E Sbjct: 5 NPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIEDVE 64 Query: 218 EAFRDADVDGALAASVFHKQIINIGELKAYLATQGVEIRI 257 E + ++ + +V + + +L + ++ + + + Sbjct: 65 E-LVNLGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVAL 103 >UniRef50_B8EIK2 Histidine biosynthesis protein n=2 Tax=Beijerinckiaceae RepID=B8EIK2_METSB Length = 237 Score = 116 bits (290), Expect = 9e-25, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 91/264 (34%), Gaps = 42/264 (15%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVP------------LAKRYAEEGADELVFYD 51 +IP +D++DG VV+ R + +A + + D Sbjct: 1 MEVIPVIDLKDGAVVRARLGRREFYA--PIESRLAATSAPGDIVAGLLSLHPFATIYIAD 58 Query: 52 ITASSDGRVVDKSWVSRVAEVID-IPFCVAGGIKSLEDAAKILSFGADKI-SINSPALAD 109 + + D R + + + E + F V G+K +A L I + + L Sbjct: 59 LN-AIDARGDHEDVLFSLEEAFPQVEFWVDAGVKDAGEARSWLLRHKRAILVLGTETLGS 117 Query: 110 PTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKR 169 + L D + I++ +D + G + + Q Sbjct: 118 SATLEILKDE---ERIILSLDFRGETFIGP---------------------EALLSAQHI 153 Query: 170 GAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVDGAL 229 ++ + + G G DL ++ V+ + + A+GG E A A VDGAL Sbjct: 154 WPSRVIAMTLGRIGANAGPDLSRIASVKALSDRKVYAAGGVRGTEDL-AALDRAGVDGAL 212 Query: 230 AASVFHKQIINIGELKAYLATQGV 253 AS H + EL A + +G+ Sbjct: 213 VASALHDGQLTSQELAAPIMAKGI 236 >UniRef50_Q1H0R8 Histidine biosynthesis n=1 Tax=Methylobacillus flagellatus KT RepID=Q1H0R8_METFK Length = 234 Score = 115 bits (288), Expect = 2e-24, Method: Composition-based stats. Identities = 42/259 (16%), Positives = 88/259 (33%), Gaps = 37/259 (14%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---IGDIVPLAKRYAEEGA-------DELVFYDIT 53 ++IP +D+ +G VV Q + ++ ++ GA L D+ Sbjct: 1 MQVIPVIDLMNGAVVHARQGNRAHYQPIVSNLCNGSEAQEIVGALLGLYPFPALYIADLD 60 Query: 54 ASSDGRVVDKSWVSR-VAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 + R ++ + +++ + V GI S+ + + + + ++ Sbjct: 61 -AIQCRNDHRTLIHTLLSKHPTLEIWVDAGINSVAKVQRW-QHPRLRPVLGTESIPSIAT 118 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 LA + I + +D G + +QE + Sbjct: 119 WHLLAGACEGRHI-LSLDFTTAGYQG--------------------PSELLQEARHWP-Q 156 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVRE-VCHVPLIASGGAGTMEHFLEAFRDADVDGALAA 231 +++ + G G D+++L R L A+GG + R + GAL A Sbjct: 157 HVIIMSLPHVGSHAGPDMDKLTHFRALSPKHHLYAAGGIRDASDL-QLLRKRGIKGALVA 215 Query: 232 SVFHKQIINIGELKAYLAT 250 S H + L++ LA+ Sbjct: 216 SALHNGNLEKSMLQSILAS 234 >UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TGW8_METVO Length = 181 Score = 114 bits (287), Expect = 2e-24, Method: Composition-based stats. Identities = 46/142 (32%), Positives = 81/142 (57%), Gaps = 5/142 (3%) Query: 80 AGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDAETGK 139 GGIK+ E+A+KI G +KIS+NS P+L+T L+ +G Q IV +D + Sbjct: 12 GGGIKTFEEASKIFELGFEKISLNSVLFEKPSLLTELSQSYGSQSIVASVDVKKNLFG-- 69 Query: 140 YHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREV 199 + Y G ++ + + LD+V+ ++ GAGE+++N ++ +G GY+L + ++ Sbjct: 70 -KLKVYNGSKNNSINDKI--LDYVKNLENLGAGELLINSVDLEGTYKGYNLSLINELSNA 126 Query: 200 CHVPLIASGGAGTMEHFLEAFR 221 +PLIA GGA + + F +A + Sbjct: 127 LTIPLIALGGASSTKDFKDALQ 148 Score = 48.3 bits (114), Expect = 3e-04, Method: Composition-based stats. Identities = 22/94 (23%), Positives = 37/94 (39%), Gaps = 7/94 (7%) Query: 6 IIPCLDVRDGQVVKGV--QFRNHEIIGD-IVPLAKRYAEEGADELVF--YDITASSDGRV 60 I+ +DV+ K + I D I+ K GA EL+ D+ + G Sbjct: 57 IVASVDVKKNLFGKLKVYNGSKNNSINDKILDYVKNLENLGAGELLINSVDLEGTYKG-- 114 Query: 61 VDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILS 94 + S ++ ++ + IP GG S +D L Sbjct: 115 YNLSLINELSNALTIPLIALGGASSTKDFKDALQ 148 >UniRef50_C0N3H2 Histidine biosynthesis protein n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N3H2_9GAMM Length = 237 Score = 114 bits (287), Expect = 2e-24, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 80/255 (31%), Gaps = 36/255 (14%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIG---------DIVPLAK-RYAEEGADELVFYDIT 53 +IIP +D+R G VV D+ + ++ D+ Sbjct: 1 MQIIPVIDIRGGIVVHARGGNRDAYSALNSVLTRSTDVFQVVNDILNWYPFEQFYIADLD 60 Query: 54 ASSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLI 113 A + + + V F + GI S +D KI I S L +L+ Sbjct: 61 AIEAAKHRPEFYAELVHCFTGTQFWLDAGITSQKDLRLYSKLHNLKIVIGSETLKSLSLL 120 Query: 114 TRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 R Q +++ +D G + N E T T Sbjct: 121 EIEGAR---QSMILSLDRRGKQLLGAH--NLLHRTELWTEQT------------------ 157 Query: 174 IVLNMMNQDGVRNGYDLEQLKKV-REVCHVPLIASGGAGTMEHFLEAFRDADVDGALAAS 232 ++ ++ G G LE L+ + + + A+GG E + G L AS Sbjct: 158 -IVMDLDVIGANQGPSLEWLQALIAQRPDIEWYAAGGVRNKADL-EQLQKIRAAGTLIAS 215 Query: 233 VFHKQIINIGELKAY 247 H I+ EL+ Sbjct: 216 ALHTGQIDKAELQKI 230 >UniRef50_C4ZG69 APG10 (Albino and pale green 10); 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase n=3 Tax=cellular organisms RepID=C4ZG69_EUBR3 Length = 261 Score = 113 bits (282), Expect = 8e-24, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 95/270 (35%), Gaps = 29/270 (10%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEIIGDIVP-----------LAKRYAEEGADELVFYDI 52 PC+D+ +G+ VK + + + GD A Y + G + Sbjct: 1 MEFRPCIDIHNGK-VKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILL 59 Query: 53 TASSDGRVVDKSWVSRVA-EVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPT 111 + D + +A E V GGI + ++A + + GA + + S D Sbjct: 60 NSVDSEYYEDTKEQAVMALEAYPQGLQVGGGI-TADNAMEFIDAGAAAVIVTSYVFKDGR 118 Query: 112 L----ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQ 167 + + RL D G +V+ + + G+Y++ E LD + Sbjct: 119 INYANLNRLKDTVGSDRLVLDLSCRK--KDGQYYIVTDRWQNFTDEAVTTELLDKLSSY- 175 Query: 168 KRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFLEAFRDADVD- 226 E +++ ++ +G NG + E + + +P+ +GG + + + R + Sbjct: 176 ---CCEFLVHAVDVEGRVNGIEKELVAMLGSWGRIPVTYAGGVSSFDDL-KCIRQLGQNH 231 Query: 227 -GALAASV--FHKQIINIGELKAYLATQGV 253 S + ++ A+ + + Sbjct: 232 LNVTIGSALDLFGGEMEYDKVIAFCNNKEI 261 >UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC778 Length = 164 Score = 113 bits (282), Expect = 8e-24, Method: Composition-based stats. Identities = 61/158 (38%), Positives = 88/158 (55%), Gaps = 5/158 (3%) Query: 16 QVVKGVQFRNHEIIGDIVPLAKRYAEEGADELVFYDITASSDGRVVDKSWVSRVAEVIDI 75 + KG +F++ + L K Y++ GADELVFYDITAS++ R +V++VAE I+I Sbjct: 8 KSCKGKKFKDIVDVDSPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENINI 67 Query: 76 PFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLITRLADRFGVQCIVVGIDTWYDA 135 PFCV GG+ LED IL GADK+SINS A+ +P LI + +FG QC+V+ ID + Sbjct: 68 PFCVGGGVNKLEDFTDILRKGADKVSINSSAVKNPELIREASLKFGAQCVVLSIDAKKNE 127 Query: 136 ETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGE 173 E + W L+ + +V + G Sbjct: 128 EGSW-----SVYVKGGREKLIWMQLNGLLKVVELGVRR 160 Score = 50.2 bits (119), Expect = 7e-05, Method: Composition-based stats. Identities = 20/87 (22%), Positives = 28/87 (32%), Gaps = 1/87 (1%) Query: 158 ETLDWVQEVQKRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPLIASGGAGTMEHFL 217 + GA E+V + LE + KV E ++P GG +E F Sbjct: 23 SPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENINIPFCVGGGVNKLEDFT 82 Query: 218 EAFRDADVDGALAASVFHKQIINIGEL 244 + R D S K I E Sbjct: 83 DILRK-GADKVSINSSAVKNPELIREA 108 >UniRef50_B2JX56 Histidine biosynthesis protein n=6 Tax=Burkholderia RepID=B2JX56_BURP8 Length = 264 Score = 112 bits (280), Expect = 1e-23, Method: Composition-based stats. Identities = 41/258 (15%), Positives = 78/258 (30%), Gaps = 21/258 (8%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAE-EGADELVFYDIT 53 ++IP LD+ DG V+ ++ + +A+ A L D+ Sbjct: 1 MQVIPVLDLLDGHAVRAIRGDRANYRPIQSSLCTTSQPLDVARALIATTAACALYVADL- 59 Query: 54 ASSDGRVVDKSWVSRVAEVID----IPFCVAGGIKSLEDAAKILSFGADKISINS--PAL 107 + D S ++ +A D + + G L A + A Sbjct: 60 GAIMSGNADPSTLAALATSSDRSRPLEIWLDAGFADFPSMLAHLERIACAPNAAPKQAAP 119 Query: 108 ADPTLITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQ 167 R+ FG + + +D +A+ Y + E D ++ Sbjct: 120 EQAAPGARIVPVFGSESL-RSLDALREADAAGYAPILSLDHRHGQLIAAPELADALRSPA 178 Query: 168 KRGAGEIVLNMMNQDGVRNGYDLEQLKKVREVCHVPL-IASGGAGTMEHFLEAFRDADVD 226 + IV+ ++Q G G + + V + I +GG +A + Sbjct: 179 SWPSRVIVMT-LDQVGSDAGPNCDTFHHVHAQAGQRMTIGAGGIRHRGDL-DAAARSGAH 236 Query: 227 GALAASVFHKQIINIGEL 244 L AS H + Sbjct: 237 AWLVASALHDGKLEPAAA 254 >UniRef50_D2QYD3 Histidine biosynthesis protein n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QYD3_9PLAN Length = 251 Score = 111 bits (279), Expect = 2e-23, Method: Composition-based stats. Identities = 49/250 (19%), Positives = 83/250 (33%), Gaps = 19/250 (7%) Query: 5 RIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYA-EEGADELVFYDITA 54 R+IP +D+ G VV+GV R E + +A+ A L D+ A Sbjct: 8 RVIPVIDLLGGIVVRGVAGRRSEYRPLESQVTRSIEPAIVARDLVHATRATALYVADLDA 67 Query: 55 SSDGRVVDKSWVSRVAEVIDIPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTLIT 114 G+ + A + V GI S DA + I + + I Sbjct: 68 IQKGQRSLSIYEQMGASGARLWLDV--GIASRADALR-FCAELAHSEIPADLVIGLESIE 124 Query: 115 RLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAGEI 174 A + + D + + + L+ + G I Sbjct: 125 TAASLV--ELGAMARDELSGSAIFSVDMRAGQLISVAAELASRMPLELASLAVRSGFTRI 182 Query: 175 VLNMMNQDGVRNG-YDLEQLKKVREVCH--VPLIASGGAGTMEHFLEAFRDADVDGALAA 231 +L ++ GV +G L +++R+ + +I GG + + L A A D L A Sbjct: 183 LLLDLSAVGVASGIPTLALARQLRDAWGSAIEIIVGGGVRSSDDLLAA-SQAGADAVLVA 241 Query: 232 SVFHKQIINI 241 S H + I Sbjct: 242 SAIHSRAIRF 251 >UniRef50_C6XDW4 Histidine biosynthesis protein n=1 Tax=Methylovorus sp. SIP3-4 RepID=C6XDW4_METSD Length = 232 Score = 111 bits (277), Expect = 3e-23, Method: Composition-based stats. Identities = 38/256 (14%), Positives = 78/256 (30%), Gaps = 38/256 (14%) Query: 4 KRIIPCLDVRDGQVVKGVQFRNHEI---------IGDIVPLAKRYAE-EGADELVFYDIT 53 IIP +D+ + VV + + + + E D L D+ Sbjct: 1 MNIIPVIDLLEHHVVHAKRGERQHYRPIESGLCDSSQPLAITRALLELYPFDTLYIADLN 60 Query: 54 ASSDGRVVDKSWVSRVAEVID-IPFCVAGGIKSLEDAAKILSFGADKISINSPALADPTL 112 + G+ ++ + + + + G K+ D + I S +L D Sbjct: 61 -AIQGKPAHVDEIALIRQHYPQLRIWLDAGFKNTRDLLPWSGLEVTPV-IGSESLPDIGA 118 Query: 113 ITRLADRFGVQCIVVGIDTWYDAETGKYHVNQYTGDESRTRVTQWETLDWVQEVQKRGAG 172 L V+ +D D G + + + + Sbjct: 119 YQELISE--GVAHVLSLDFRGDRYQGP---------------------EALLDNPRLWPQ 155 Query: 173 EIVLNMMNQDGVRNGYDLEQLKKVREVCHV-PLIASGGAGTMEHFLEAFRDADVDGALAA 231 ++ + G G D +L+++ + L +GG + R+ + GAL A Sbjct: 156 LVIGMTLANVGSNQGPDHARLQQLVGMAQHGKLYGAGGVRDINDLQR-LREQGIAGALVA 214 Query: 232 SVFHKQIINIGELKAY 247 S H I+ ++ Sbjct: 215 SALHSGQISSQDIAHI 230 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.313 0.155 0.424 Lambda K H 0.267 0.0477 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,760,958,225 Number of Sequences: 3077464 Number of extensions: 85313250 Number of successful extensions: 276998 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1343 Number of HSP's successfully gapped in prelim test: 1539 Number of HSP's that attempted gapping in prelim test: 269377 Number of HSP's gapped (non-prelim): 5376 length of query: 258 length of database: 1,040,396,356 effective HSP length: 126 effective length of query: 132 effective length of database: 652,635,892 effective search space: 86147937744 effective search space used: 86147937744 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 92 (39.8 bits)