BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (222 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 378 e-103 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 338 8e-92 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 312 5e-84 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 310 3e-83 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 291 1e-77 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 278 1e-73 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 267 2e-70 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 262 7e-69 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 250 3e-65 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 248 2e-64 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 244 2e-63 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 241 2e-62 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 222 8e-57 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 218 9e-56 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 161 1e-38 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 149 1e-34 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 113 6e-24 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 112 1e-23 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 111 2e-23 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 109 6e-23 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 104 2e-21 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 103 4e-21 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 102 1e-20 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 101 2e-20 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 101 2e-20 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 100 4e-20 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 100 7e-20 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 97 4e-19 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 96 9e-19 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 95 1e-18 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 94 5e-18 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 93 7e-18 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 92 2e-17 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 92 2e-17 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 90 5e-17 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 88 2e-16 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 87 5e-16 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 86 1e-15 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 84 3e-15 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 82 2e-14 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 80 4e-14 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 80 7e-14 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 79 1e-13 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 77 3e-13 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 74 3e-12 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 74 3e-12 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 74 4e-12 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 74 5e-12 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 74 5e-12 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 74 5e-12 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 72 2e-11 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 72 2e-11 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 70 4e-11 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 70 5e-11 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 70 6e-11 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 69 1e-10 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 69 2e-10 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 67 4e-10 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 67 4e-10 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 67 5e-10 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 67 5e-10 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 66 8e-10 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 65 1e-09 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 65 1e-09 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 65 2e-09 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 65 2e-09 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 64 4e-09 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 64 4e-09 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 63 6e-09 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 63 6e-09 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 63 6e-09 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 63 8e-09 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 63 9e-09 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 62 2e-08 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 62 2e-08 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 61 4e-08 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 60 4e-08 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 60 5e-08 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 59 9e-08 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 57 4e-07 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 57 6e-07 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 56 8e-07 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 56 8e-07 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 56 8e-07 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 56 1e-06 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 55 1e-06 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 54 3e-06 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 54 5e-06 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 52 1e-05 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 52 1e-05 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 52 2e-05 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 51 2e-05 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 51 3e-05 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 51 3e-05 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 51 3e-05 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 51 4e-05 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 50 5e-05 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 50 5e-05 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 50 7e-05 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 50 8e-05 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 49 9e-05 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 49 1e-04 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 49 1e-04 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 49 2e-04 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 48 2e-04 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 48 3e-04 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 48 3e-04 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 47 5e-04 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 46 8e-04 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 46 9e-04 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 46 9e-04 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 46 0.001 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 46 0.001 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 46 0.001 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 46 0.001 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 45 0.001 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 45 0.002 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 44 0.003 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 44 0.006 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 43 0.010 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 42 0.018 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 42 0.020 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 40 0.043 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 378 bits (970), Expect = e-103, Method: Compositional matrix adjust. Identities = 175/222 (78%), Positives = 200/222 (90%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVD++P M+KVVDAAVEKAYKGERKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y Sbjct: 39 IGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYV 98 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGGIRSLNVALRQ+LDLY+C RPVR+++G PSPVK P DMVIFRENS Sbjct: 99 VSIKGPLTTPVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENS 158 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAG+EWKA S +AEKVIKFL EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++Y Sbjct: 159 EDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQY 218 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A+ NDR SVTLVHKGNIMKFTEGAFKDWGY++AR+EFG EL+ Sbjct: 219 AVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELL 260 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 338 bits (867), Expect = 8e-92, Method: Compositional matrix adjust. Identities = 157/222 (70%), Positives = 189/222 (85%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVTP MLKVV+AAV KAY G+RKI W+E+Y GEK+T++Y + WLP ETL++++EY+ Sbjct: 37 IGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYK 96 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGG+ SLNVA+RQ LDLY+C RPV+++ G PSPVK P DMVIFREN+ Sbjct: 97 VSIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENT 156 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE+KA S A+ VIKFL EEMG IRF E+CGIGIKP S+EG++RLVR AI+Y Sbjct: 157 EDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQY 216 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N++DSVTLVHKGNIMKFTEGAFKDWGY+LA EEFG L+ Sbjct: 217 AIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLL 258 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 312 bits (799), Expect = 5e-84, Method: Compositional matrix adjust. Identities = 147/222 (66%), Positives = 178/222 (80%), Gaps = 2/222 (0%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG D+ A +V+DAAVEKAY GE++I W E+ G+K+ G+ WLP ETLD I+EY Sbjct: 29 IGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGE--WLPQETLDTIKEYL 86 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLRPVR+++G PSPVK P+ DMVIFREN+ Sbjct: 87 IAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENT 146 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE+K + + +KVI FL+ EMG IRFPE GIGIKP S+EGT+RLVRAAI+Y Sbjct: 147 EDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQY 206 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N+R SVTLVHKGNIMKFTEG+FK WGY LA EFG ++ Sbjct: 207 AIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVF 248 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 310 bits (793), Expect = 3e-83, Method: Compositional matrix adjust. Identities = 147/229 (64%), Positives = 186/229 (81%), Gaps = 8/229 (3%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG-------QDVWLPAETL 53 IG D+TPAM+KVVD+AV+KAYKGE+KI+W E++ GEK Q + ++ WL +T+ Sbjct: 40 IGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTI 99 Query: 54 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 + I Y+V+IKGPLTTP+G G RSLNVALRQ++DLY+CLRPVR+Y G+PSPVK P+ DM Sbjct: 100 EAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDM 158 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 VIFRENSEDIYAGIEW+ SA+A+K+I FL+ E+ V+KIRFPE G+GIKP S+EGT+RL Sbjct: 159 VIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPISKEGTERL 218 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 VR AIEYAI ND+ SVT VHKGNIMK+TEGAF WGY LA++EF ++I Sbjct: 219 VRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQVI 267 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 291 bits (744), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 135/183 (73%), Positives = 157/183 (85%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG+D++P M+KVVDAAV+KAY GERKISWME+Y GEK+TQVY QD WLP ETLD +++Y Sbjct: 39 IGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYV 98 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGGIRSLNVALRQ+LDLY+CLRPVR+++G PSPVK P DM IFRENS Sbjct: 99 VSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENS 158 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIEWKA S +A KVIKFL+EEMGV KIRF + CGIG+KP S+EGTKRL R A+ Sbjct: 159 EDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHS 218 Query: 181 AIA 183 A A Sbjct: 219 AEA 221 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 278 bits (710), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 120/217 (55%), Positives = 173/217 (79%), Gaps = 1/217 (0%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G DV P M KVVD+A+ Y+ +RKI WM++Y GE++ ++Y D W P ET++ +RE + Sbjct: 42 VGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGD-WFPQETINAVRECK 100 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +AIKGPLTTP+GGG RSLNVALRQE+DL++ +R ++ + PSP+K+P LT++ + R++S Sbjct: 101 IAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSS 160 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y+GIEW+A S ++EKV+ FL EEMGV ++RF + CGIGIK S+EG++RLVR AI Y Sbjct: 161 EDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINY 220 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A+ N+ +S+TLVHKGN++KFT+GAFK WG+ LA+ E+ Sbjct: 221 ALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREY 257 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 267 bits (683), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 131/217 (60%), Positives = 161/217 (74%), Gaps = 3/217 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DV PA KV++AA E R ISWM +Y GE + + YG+DV LP ET+D IRE+R Sbjct: 41 IGKDVGPAAQKVLEAAAEATG---RDISWMRVYAGESAREEYGEDVNLPDETVDAIREHR 97 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGPLTTPVG G RSLNVALRQ LDLY +RP Y G PSP+K PE DMV FREN+ Sbjct: 98 VAIKGPLTTPVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENT 157 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW+A + + E+V +F+ +EMG + GIG+KP +E+G+KRLVR AI+Y Sbjct: 158 EDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A+ +DRD VTLVHKGNIMKFTEG F DWG ++A EE+ Sbjct: 218 ALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEY 254 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 262 bits (669), Expect = 7e-69, Method: Compositional matrix adjust. Identities = 128/230 (55%), Positives = 169/230 (73%), Gaps = 11/230 (4%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G+D+ PA KV+DAAV KAY G+RKISW ++Y G+++ +YG +LP +TL I+EY + Sbjct: 38 GIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGI 97 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 AIKGPLTTP+GGGIRSLNVALRQ DLY C+RP RYY GTPSP K P+ D++++REN+E Sbjct: 98 AIKGPLTTPIGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTE 157 Query: 122 DIYAGIEWKADSADAEKVIKFLREEM-------GVKKIRFPEHCGIGIKPCSEEGTKRLV 174 DIY GIEWK S E++I L +++ G K+I P GIGIKP S G++RLV Sbjct: 158 DIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQI--PLDAGIGIKPISRSGSQRLV 215 Query: 175 RAAIEYA--IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 R A+++A + ++ VTLVHKGNIMK+TEGAF+DWGY+LA +EF E + Sbjct: 216 RRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELATQEFRAECV 265 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 250 bits (638), Expect = 3e-65, Method: Compositional matrix adjust. Identities = 126/230 (54%), Positives = 163/230 (70%), Gaps = 11/230 (4%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 GVD+ PA V++AA+ KAY G +I+W ++Y G+++ ++YG P +TL I+EY V Sbjct: 38 GVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGV 97 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 AIKGPLTTPVGGGIRSLNVALRQ DLY C+RP RYY GTPSP K PE D++++REN+E Sbjct: 98 AIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTE 157 Query: 122 DIYAGIEWKADSADAEKVIKFLREE-------MGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 DIY GIEW + A+K+I +L +E +G K+IR GIGIKP S+ G++RLV Sbjct: 158 DIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRL--DSGIGIKPISKTGSQRLV 215 Query: 175 RAAIEYA--IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 R AI +A + + VTLVHKGNIMKFTEG F+DWGY+LA EF E + Sbjct: 216 RRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELATTEFRAECV 265 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 248 bits (632), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 120/222 (54%), Positives = 160/222 (72%), Gaps = 3/222 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A V DAAV+KAY G+++++W+ + GE + + GQ WLP +TL +REY Sbjct: 29 IGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQ--WLPDKTLATLREYL 86 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV YY GTPSPV HPE ++ +FREN+ Sbjct: 87 VGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPVVHPENVNIDVFRENT 146 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE D+ DAE+ L ++ + K+RFP+ IKP S++G+ RLV AAI+Y Sbjct: 147 EDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIKPISKQGSTRLVDAAIDY 206 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A AN+R ++TLVHKGNIMK TEG FK WGY+ A E++G ++ Sbjct: 207 AFANNRHTLTLVHKGNIMKKTEGGFKKWGYE-AAEKYGDKVF 247 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 244 bits (622), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 123/217 (56%), Positives = 156/217 (71%), Gaps = 5/217 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DV PA KV++AA A R+ISWM ++ GE + + Y ++ LP +T++ I E+R Sbjct: 43 IGKDVGPAAQKVLEAA---ANATGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHR 97 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGPLTTPVG G RSLNVALRQ LD Y +RP Y G PSP+K PE DMV FREN+ Sbjct: 98 VAIKGPLTTPVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENT 157 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW+A + + E+V +F+ E+MG + GIGIKP +E G+KRLVR AI+Y Sbjct: 158 EDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 AI +DRD VTLV KGNIMKFTEG F +WG ++A EE+ Sbjct: 218 AIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEY 254 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 241 bits (614), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 117/217 (53%), Positives = 161/217 (74%), Gaps = 5/217 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A +KV + AVEKAY R+I+W EI GEK+ +++G LP ++++++R+ R Sbjct: 55 IGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNR--LPDQSIEVLRKIR 112 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K PL TPVGGG RS+NV LRQ DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ Sbjct: 113 VFLKAPLETPVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENT 172 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW +S +A K+ +FLR E GV IR + GIGIKP S+ GT+R+ R A+++ Sbjct: 173 EDVYAGIEWPYNSPEAAKIREFLRREFGV-NIR--DDAGIGIKPISKFGTQRIARLALKF 229 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 AI N R VT++HKGNI K+TEGAFK+W +++AR EF Sbjct: 230 AIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEF 266 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 222 bits (565), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 110/223 (49%), Positives = 161/223 (72%), Gaps = 4/223 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T AML +++ AVEK Y G +KI W+E+ G+K+ + G+ LP ETLD+++E Sbjct: 49 IGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGER--LPQETLDVLKESI 106 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGPL TPVG G+RS+N ALR+ D Y +RPV Y+ G +P+ +PE D+V+FREN+ Sbjct: 107 VGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENT 165 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 +D+YAG+E+ A + +A+KV +FL +EMG K+ FPE GI +KP SE TKR VR A+ Y Sbjct: 166 DDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRY 225 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE-EFGGELI 222 A+ N++ +V ++ KGNIMK TEGAF +W +++A E EF G+++ Sbjct: 226 ALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVV 268 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 218 bits (556), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 116/217 (53%), Positives = 147/217 (67%), Gaps = 6/217 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + KV+DAAV+KAY G R+I W E+ GE++ + G LP TL + R Sbjct: 43 IGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGS--LLPDGTLQAFKLAR 100 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPLTTPVGGG RSLNV LR LDLY +RPV++Y G P+P HPE D VIFREN+ Sbjct: 101 VNLKGPLTTPVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENT 159 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW DS +A+K+ FL++E G I GIGIKP S+ T+R VR A+E+ Sbjct: 160 EDVYAGIEWPFDSPEAQKIRDFLKKEFG---IELTPDTGIGIKPISKWRTQRHVRRAMEW 216 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 AI N VT++HKGNIMK+TEGAF+ W Y L EF Sbjct: 217 AIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEF 253 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 161 bits (408), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 97/216 (44%), Positives = 131/216 (60%), Gaps = 17/216 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT AM V++A+ + W+ + G + + YG LP + L+ IRE R Sbjct: 13 IGPEVTRAMTTVLEAS-------GVDLEWIRVEAGVEVIEKYGTP--LPPQVLESIRETR 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + D+V+ REN+ Sbjct: 64 VAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQD---IDLVVVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRF-PEHCGIGIKPCSEEGTKRLVRAAIE 179 ED+YAGIE++ + +A REEM +F E IGIKP SE G++R+V+ A E Sbjct: 121 EDLYAGIEFERGTPEAAHA----REEMMRLSGKFIREGSAIGIKPISEFGSRRIVKFAFE 176 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 YA N R VT VHK NIMKFT+G F ++A+E Sbjct: 177 YARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQE 212 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 149 bits (375), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 79/168 (47%), Positives = 112/168 (66%), Gaps = 5/168 (2%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 LP L+ IR +VA+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S ++ Sbjct: 51 LPDSVLESIRSTKVALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRFEN 110 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 D+V+ REN+ED+YAGIE++ + + ++ +L ++ I+ P GI IKP S Sbjct: 111 ---IDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEP--GGISIKPMSV 165 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 G++R+VR A EYA AN R VT VHK NIMKF++G F + ++A+E Sbjct: 166 PGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKE 213 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 113 bits (282), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 77/217 (35%), Positives = 115/217 (52%), Gaps = 37/217 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY--GQDVWLPAETLDLIRE 58 IG ++T A++ ++ AA ++E+ GE QVY G +P E D I Sbjct: 32 IGPEITAAVMSILSAA-----GAHLDAEYVEV--GE---QVYLRGNTSGIPQEAWDSIAR 81 Query: 59 YRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 RV +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ + +HP++ D+VI RE Sbjct: 82 TRVMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYKPIVT-TRHPDM-DVVIVRE 139 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N ED+YAGIE + + D + +K + + G++R+ R A Sbjct: 140 NEEDLYAGIEHR-QTQDVAQCLKLI----------------------TRSGSERIARYAF 176 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 EYA + R +T + K NIMK T+G F ++ARE Sbjct: 177 EYARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVARE 213 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 112 bits (280), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 70/190 (36%), Positives = 99/190 (52%), Gaps = 9/190 (4%) Query: 26 KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQE 85 KI W G+++ + + LP TL+ IR A+KGP TTP+G G RS+N+ +RQE Sbjct: 36 KIDWDVHQAGQRA--LAESESLLPDATLNSIRTNGAALKGPTTTPIGTGHRSVNITIRQE 93 Query: 86 LDLYICLRPVRYYQGTPSPVKHPE--LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFL 143 LDLY CLRPVR S + PE D+V+ REN+ED+YAG+E+ S A V++ L Sbjct: 94 LDLYACLRPVRSLP-IASTQEEPERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQAL 152 Query: 144 REEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG 203 G P + +KP + G +R+V A +A + R V V TEG Sbjct: 153 ----GALGRPLPADTAVSLKPFTPHGCERVVEFAFNHAARHGRKLVESVCDARRYPATEG 208 Query: 204 AFKDWGYQLA 213 F ++A Sbjct: 209 MFARVASKVA 218 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 111 bits (277), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 78/220 (35%), Positives = 117/220 (53%), Gaps = 25/220 (11%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A V+D A A + W G+ + + G+ LPA TLD IR V Sbjct: 15 GPELVAAARTVLDTAAGSA---GFHLDWDVRPAGQGALRSVGE--LLPASTLDSIRRNGV 69 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + D+V+ REN+E Sbjct: 70 ALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAVDSG---IDVVVVRENTE 126 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI----KPCSEEGTKRLVRAA 177 D+Y+G+E+ ADS D V+ E G H GI KP + G++R+V A Sbjct: 127 DVYSGLEYPADS-DGAAVVSATLSEFG--------HADPGIAFSLKPITPGGSRRIVAFA 177 Query: 178 IEYAIANDRDSVTLVHKGNIMKF--TEGAFKDWGYQLARE 215 +++A N R V + ++ ++ TEG F + +L E Sbjct: 178 LDHARKNGRRKVEV--GADVYRYPRTEGLFFEAARELGPE 215 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 109 bits (273), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 70/205 (34%), Positives = 111/205 (54%), Gaps = 33/205 (16%) Query: 13 VDAAVEKAYK-GERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV 71 + AAV++ +K + I W + + T+ +P +LD+IR++ + +KGPL TP+ Sbjct: 1991 ISAAVQEIFKFADVPIKWESVDVTPRPTE--DGRFRMPQSSLDIIRKHGIGLKGPLATPI 2048 Query: 72 GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 131 G G +SLN+ALR+E +LY +RP + +G +P K+ D+V REN+E Y+GIE Sbjct: 2049 GKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYKN---VDLVTVRENTEGEYSGIE--- 2102 Query: 132 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTL 191 + V++ IK +EE ++R+ R A +YA N R SVT Sbjct: 2103 -HVIVDGVVQ-------------------SIKLITEEASRRVARFAFQYAKDNGRRSVTA 2142 Query: 192 VHKGNIMKFTEGAFKDWGYQLAREE 216 VHK NIM+ ++G F ++ REE Sbjct: 2143 VHKANIMRMSDGLF----LRVCREE 2163 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 104 bits (259), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 73/217 (33%), Positives = 115/217 (52%), Gaps = 33/217 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G DV A L V+DA V+K + + I ++ G + + YG + LP ETLD ++E Sbjct: 16 VGPDVINASLLVLDA-VKKKFNLD--IEYVPAVAGLNTVEKYGTN--LPKETLDTLKETD 70 Query: 61 VAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +KGP TTP G + S NV +R+ DLY +RP + PS P + DMVI REN Sbjct: 71 CVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI--KPNV-DMVIVREN 127 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E +Y+G+++ R + IGI+ + + +R+V+ A + Sbjct: 128 TEGMYSGLDF-----------------------RVNQETTIGIRVITRKACERIVKYAFK 164 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + + VTLVHKGN++K ++G FKD Y+ A++ Sbjct: 165 LA-ESRKKHVTLVHKGNVLKVSDGMFKDIFYEEAKKH 200 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 103 bits (257), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 62/172 (36%), Positives = 92/172 (53%), Gaps = 8/172 (4%) Query: 44 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 103 Q LP D+IR + A+ GPL P R + +R++LDLY+ LRP + G PS Sbjct: 44 QQGLLPNYIFDIIRTAKTAVIGPLMMP--DNYRQMEADIREKLDLYVNLRPAKTMVGIPS 101 Query: 104 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 163 ++ D++I RE +E IYAGIE++ S +A FL + G K+IR E +GIK Sbjct: 102 NYQN---VDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSG-KRIR--EDAAVGIK 155 Query: 164 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 P S +G +++ A YA R V VH+ + M T+G F + +A+E Sbjct: 156 PISVKGCGQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQE 207 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 102 bits (253), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 69/206 (33%), Positives = 105/206 (50%), Gaps = 28/206 (13%) Query: 11 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 70 ++++A + K E +I I GEK V + ++ + I V +K P+TTP Sbjct: 18 EIMEAVLYILRKAEARIRLETIEVGEK-LYVKHYSSGISEQSWESIERTGVILKAPITTP 76 Query: 71 VGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEW 129 GGG +SLNV +R+ L L+ +RP V +Y T + HP L ++ I REN ED+YAGIE+ Sbjct: 77 QGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL--HPNL-NLTIIRENEEDLYAGIEY 133 Query: 130 KADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSV 189 + E V K S G ++++R A EYA+ N+R V Sbjct: 134 RQTHNMYESV-----------------------KLISRTGCEKIIRYAFEYAVKNNRKKV 170 Query: 190 TLVHKGNIMKFTEGAFKDWGYQLARE 215 T + K NIMKF++G F ++A+E Sbjct: 171 TCLSKDNIMKFSDGIFHKVFNEIAKE 196 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 76/216 (35%), Positives = 105/216 (48%), Gaps = 34/216 (15%) Query: 1 IGVDVTPAMLKVVDAA-VEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREY 59 IG + A LKV++AA AY E+ S G +P ET++ IR+ Sbjct: 30 IGPECVEATLKVLEAAKAPLAY---------EVREAGASVFRRGIASGVPQETIESIRKT 80 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 RV +KGPL TPVG G +S NV LR+ + Y +RPVR + P+P + D+V+ REN Sbjct: 81 RVVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRGI-DLVVVREN 139 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 ED+YAGIE + A+ +K S +G++++VR A E Sbjct: 140 VEDLYAGIEHMQTPSVAQT-----------------------LKLISWKGSEKIVRFAFE 176 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A A R V K NIMK EG K Q+A+E Sbjct: 177 LARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQE 212 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 101 bits (251), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 70/215 (32%), Positives = 99/215 (46%), Gaps = 31/215 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ +++ V+DA W Y G + G LP ET+ I + Sbjct: 23 IGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGDP--LPRETIQSIHHNK 73 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+KGPLTTP GGG RS+NV LR+E +L+ +RP T P E D+ + REN Sbjct: 74 LALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPAL----TLIPGGRFENVDITLIRENL 129 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + YA E D P + + G R++R A EY Sbjct: 130 DGFYAAFEHYMPIGDD------------------PHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A+ N R VTLVHK NI+K G F + G ++A+E Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKE 206 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 100 bits (249), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 60/166 (36%), Positives = 91/166 (54%), Gaps = 27/166 (16%) Query: 51 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPE 109 +T I + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + PE Sbjct: 57 DTWSQIFRTKALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSA--PE 114 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 + D+VI REN ED+YAGIE+ +AD + +K + S G Sbjct: 115 I-DVVIIRENEEDLYAGIEYH-HTADTYESVKLI----------------------SRSG 150 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 +++++R A EYA+ N+R +++ K NIMKFT+G F ++A + Sbjct: 151 SEKIIRFAFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQ 196 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 99.8 bits (247), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 107/215 (49%), Gaps = 35/215 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT A ++V++A K W G ++ + Y + ++P E + I R Sbjct: 13 IGPEVTSAAVRVLEAT-------GLKFEWESFAAGAEAYEKYKE--YIPKELNESIERTR 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + ++P + D+V+ REN+ Sbjct: 64 IGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHT--RYPGV-DLVVVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+GIE + E +K +E+ + R+ + A Y Sbjct: 121 EGLYSGIEHEVVPGVVES-----------------------LKIITEKASTRISKFAFNY 157 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A R + +HK NIMK ++G F +++E Sbjct: 158 ARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKE 192 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 97.1 bits (240), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 62/168 (36%), Positives = 90/168 (53%), Gaps = 24/168 (14%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 +P +T++ I+ RV +KGPL TPVG G +S NV LR+ + + +RPVR P+P + Sbjct: 70 VPDDTIESIKRTRVVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG 129 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 + D+V+ REN ED+YA IE+ RE GV I K S Sbjct: 130 RNI-DLVVVRENIEDLYAAIEY--------------RETPGVT---------IAHKLISY 165 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 +G+++++R A E A A R VT K NI+K TEG F+ ++A E Sbjct: 166 KGSEKIIRFAFELARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASE 213 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 95.9 bits (237), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 69/207 (33%), Positives = 101/207 (48%), Gaps = 32/207 (15%) Query: 12 VVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV 71 +V AVE+ + E Y +V G +P E ++ ++ +V +KG L TPV Sbjct: 52 LVTGAVEQVMEAMHAPVHFERY------EVLGNMRKVPEEVIESVKRNKVCLKGGLATPV 105 Query: 72 GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKA 131 GGG+ SLN+ LR+ELD++ L P V E D+V+ REN+E Y+G+E Sbjct: 106 GGGVSSLNMQLRKELDIFASLVNC---INVPGLVTRHENVDIVVIRENTEGEYSGLE--- 159 Query: 132 DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTL 191 +V+ + E + V K CSE R+ R A EYA N+R VT Sbjct: 160 -----HEVVPGVVESLKVIT-----------KFCSE----RIARYAFEYAYLNNRKKVTA 199 Query: 192 VHKGNIMKFTEGAFKDWGYQLAREEFG 218 VHK NIMK +G F + ++A+ G Sbjct: 200 VHKANIMKLADGLFLESCREVAKHYSG 226 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 95.1 bits (235), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/162 (35%), Positives = 87/162 (53%), Gaps = 32/162 (19%) Query: 56 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 ++ +V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P D+VI Sbjct: 59 LKRNKVLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDPK-----MDIVI 113 Query: 116 FRENSEDIYAGIEWKA--DSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 REN ED+Y+GIE++ D+ + KVI +E ++R+ Sbjct: 114 IRENEEDLYSGIEYRQTLDTYNCTKVI-------------------------TESTSERI 148 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 R A EYA +N R VT++ K NIMK T+G F ++A E Sbjct: 149 CRYAFEYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALE 190 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 93.6 bits (231), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 62/173 (35%), Positives = 87/173 (50%), Gaps = 36/173 (20%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPS 103 +PAE L ++E V +KGP TTP G + S NVA+R+ELDL+ +RPVR Sbjct: 97 IPAEVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRI------ 150 Query: 104 PVKHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 162 PE D +REN+E YA +G K I E G+ Sbjct: 151 ----PEQGIDWTFYRENTEGAYA---------------------VGSKGIHVTEDLGVDF 185 Query: 163 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + G++R++RAA EYA AN + VT V K NI+K T+G F D ++A++ Sbjct: 186 TVVTSGGSERIIRAAFEYAKANGKTRVTAVTKANIIKTTDGKFLDIFREIAKD 238 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 92.8 bits (229), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 73/223 (32%), Positives = 109/223 (48%), Gaps = 49/223 (21%) Query: 1 IGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVY--GQDVWLPAETLDLIR 57 IG ++ A LKV+ +A E +EI E +VY G + + + ++ Sbjct: 14 IGPEIMDATLKVILEAGAE-----------LEIEKIEIGFKVYSMGNPSGIEPSSWESLK 62 Query: 58 EYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP---VKHPELTDMV 114 +V +K P+TTP GGG +SLNV +R+ L LY +RP Y +P KHP + D+V Sbjct: 63 RTKVFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY----APFIHTKHPGI-DLV 117 Query: 115 IFRENSEDIYAGIEWK--ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 I REN ED+Y GIE + DS A K++ + +GT+R Sbjct: 118 IIRENEEDLYGGIEHRQGVDSFQALKIM-------------------------TRQGTER 152 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 ++R A EYA R V+ K NI+K T+G F ++A+E Sbjct: 153 IIRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKE 195 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 91.7 bits (226), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 57/179 (31%), Positives = 95/179 (53%), Gaps = 30/179 (16%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 +P + ++ +R VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G +P + Sbjct: 102 IPDDAIESVRRNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPYDN 161 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 D V+ REN+E Y+GIE + V++ IK ++ Sbjct: 162 ---VDTVLIRENTEGEYSGIEHVV----VDGVVQ-------------------SIKLITK 195 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELI 222 E ++R++R A +YA + ++ V +VHK IMK ++G F + ++A++ EF EL+ Sbjct: 196 EASERVLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELL 254 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 91.7 bits (226), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/203 (31%), Positives = 100/203 (49%), Gaps = 25/203 (12%) Query: 27 ISWMEIYTG----EKSTQVYGQD----VWLPAETLDLIREYRVAIKGPLTTPVG-GGIRS 77 I W+ G EKS +GQ +P ET+D IR + +T+ G G +S Sbjct: 44 IDWVRADLGWCMWEKSVNKFGQGDPRCNTVPPETIDKIRSSDATLMAAITSKSGVKGFKS 103 Query: 78 LNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAE 137 + +RQ DLYI LRP + SP+K D+V+FREN+ED+Y+ +E+ Sbjct: 104 AILQMRQLFDLYINLRPAKTLPDLGSPLKGDPKIDLVLFRENTEDLYSAVEFHP------ 157 Query: 138 KVIKFLREEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 192 L EEM G+++ R + + S G +R++RAA EYA + R V Sbjct: 158 -----LPEEMFNLHKGMERFRKMGDVAVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCC 212 Query: 193 HKGNIMKFTEGAFKDWGYQLARE 215 +K N+++ T+G K ++A+E Sbjct: 213 NKANVIRETDGMMKRIFLEVAKE 235 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 90.1 bits (222), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 62/205 (30%), Positives = 100/205 (48%), Gaps = 35/205 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A++K+ DAA ER ++ + Q G +P+E + + + + Sbjct: 42 IGPEISAAVMKIFDAAKAPIQWEERNVT---------AIQGPGGKWMIPSEAKESMDKNK 92 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGPL TP+ G S+N+ LR+ DLY +RP +G +P ++V REN+ Sbjct: 93 MGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTD---VNIVTIRENT 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + V++ IK +E +KR+ A EY Sbjct: 150 EGEYSGIE----HVIVDGVVQ-------------------SIKLITEGASKRIAEFAFEY 186 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAF 205 A N R +VT VHK NIM+ ++G F Sbjct: 187 ARNNHRSNVTAVHKANIMRMSDGLF 211 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 87.8 bits (216), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 51/167 (30%), Positives = 84/167 (50%), Gaps = 26/167 (15%) Query: 39 TQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYY 98 T V + + E ++ I + ++ +KGP++TP+G G +SLN+ LR+ +LY +RP Sbjct: 57 TVVVDANTGISKEVIESISKNKIGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCLSI 116 Query: 99 QGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 158 G + + + V+ REN+E Y+GIE + A+ Sbjct: 117 PGHKTRYNN---VNTVVVRENTEGEYSGIENQPVKGVAQS-------------------- 153 Query: 159 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 IK ++E + R+ A +YA+AN R VT +HK NIMK ++G F Sbjct: 154 ---IKIITKEASTRIAHYAFQYALANGRKKVTCIHKANIMKQSDGLF 197 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 86.7 bits (213), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 61/229 (26%), Positives = 116/229 (50%), Gaps = 17/229 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T AM+ VV++A+E AY+G R I W +I G ++ + +G ++P +++ I++ Sbjct: 34 IGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFG--TYVPEDSIKEIQKMY 91 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+K L R LN LR+ L LY +R ++Y +G PV ++ I R+++ Sbjct: 92 IAMKSTLN--FMPDKRDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTIIRDST 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + + + S + +I+F+ + G + GI + P S+ T+++ + A+ Y Sbjct: 150 PNSHI---FYHSSESTDDLIRFISDNYG---LNITPDSGIYMMPQSKFRTRKIAKQAVRY 203 Query: 181 AIANDRDSVTLVHKGNIMKFTE------GAFKDWGYQ-LAREEFGGELI 222 + N + +T++ +F A +D GY+ L EF LI Sbjct: 204 SRRNGKKKITILESQQNHEFANWCIEEASAQEDVGYEVLKTREFMKRLI 252 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 85.5 bits (210), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/152 (40%), Positives = 79/152 (51%), Gaps = 33/152 (21%) Query: 56 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPV---KHPELT 111 I R+ +K P TP G G +SLNVALRQ L LY+ +RP V Y+ PV KHP+L Sbjct: 65 ISRTRLLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSYF-----PVVGTKHPDL- 118 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D+VI REN ED Y+G+E K S D + +K I + SE Sbjct: 119 DVVIIRENEEDTYSGVEHKL-SEDTHECVK------------------ISTRSASE---- 155 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEG 203 ++ A YA A++R VT K NIMK T+G Sbjct: 156 KICAYAFNYARAHNRKKVTCFVKDNIMKMTDG 187 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 84.3 bits (207), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 99/217 (45%), Gaps = 39/217 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISW--MEIYTGEKSTQVYGQDVWLPAETLDLIRE 58 IG +++ A+ + AA + I W EIYT K G + E+L+ + Sbjct: 315 IGPEISQAVCDIFAAA-------KVPIDWEHHEIYT--KPINEAGD--LIKEESLNAVIN 363 Query: 59 YRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 Y+ +KGP TP+G G RSLNV +R++L+L+ +RP R G +P + D+V RE Sbjct: 364 YKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYSN---VDLVTIRE 420 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+G+E E +K S+ + + R A Sbjct: 421 NTEGEYSGLEHAVVPGVVE-----------------------NLKIISQPACENIARYAF 457 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 E+A N+R V HK +MK +G F + +++ E Sbjct: 458 EFARKNNRKKVVACHKAGVMKKGDGLFINTCKKISSE 494 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 53/168 (31%), Positives = 84/168 (50%), Gaps = 26/168 (15%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 +P + I + VA+KGPL TP+G G RSLN+ LR+ L+ +RP + +G + Sbjct: 84 IPDPAVQSITKNLVALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY-- 141 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 E D+V+ REN+E Y+GIE V++ IK + Sbjct: 142 -ENVDLVLIRENTEGEYSGIEHIV----CPGVVQ-------------------SIKLITR 177 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + ++R++R A EYA A R V +VHK I + +G F + +L++E Sbjct: 178 DASERVIRYAFEYARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKE 225 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 80.1 bits (196), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 53/165 (32%), Positives = 82/165 (49%), Gaps = 27/165 (16%) Query: 51 ETLDLIREYRVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 E + ++ +V +KG L TP GG S NVALR+ELD+Y L ++ G + +H Sbjct: 73 EAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT--RHDN 130 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 + D I REN+E Y+G+E ++ E +K +E Sbjct: 131 V-DFAIIRENTEGEYSGLEHQSVPGVVES-----------------------LKIITEYK 166 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 +KR+ + A ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 167 SKRIAQFAFDFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVAN 211 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 79.7 bits (195), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 105/219 (47%), Gaps = 52/219 (23%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV---YGQDVWLPAETLDLIR 57 IG +V P +K+++ ++ EI GE + YG LP +T++ + Sbjct: 12 IGKEVIPEAIKILN-----------ELGEFEIIKGEAGLECLKKYGN--ALPEDTIEKAK 58 Query: 58 EYRVAIKGPLTTPVGGGIRSLN---VALRQELDLYICLRPVRYY-------QGTPSPVKH 107 E + + G +T+P G +++ + LR+ LY +RP+ + + + Sbjct: 59 EADIILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLN 118 Query: 108 PELTDMVIFRENSEDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 166 + D+VI REN+ED+Y G E + D+A AE+VI + Sbjct: 119 AKNIDIVIIRENTEDLYVGRERLENDTAIAERVI-------------------------T 153 Query: 167 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 +G++R++R A EYAI N+R V+ +HK N+++ T+G F Sbjct: 154 RKGSERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLF 192 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 79.0 bits (193), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/216 (29%), Positives = 101/216 (46%), Gaps = 42/216 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGV+V A L +++ + + ++ G+ + G LP ETL+ + E R Sbjct: 14 IGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TALPEETLEAVGEAR 64 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V LR+E DL+ LRPV+ G P +P+L D VI REN+ Sbjct: 65 ATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVP--CLYPDL-DFVIVRENT 117 Query: 121 EDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 ED+Y G E + + A A+++I + ++R+ + A + Sbjct: 118 EDLYVGDEEYTPEGAVAKRII-------------------------TRTASRRISQFAFQ 152 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 YA VT VHK N++K T+G F+D Y++A E Sbjct: 153 YAQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASE 188 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 77.4 bits (189), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/162 (30%), Positives = 77/162 (47%), Gaps = 28/162 (17%) Query: 47 WLPAETLDLIREYRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 105 ++P T+ ++ E KGP TT PV G RS+ V LRQ+ DLY +RP + Y Sbjct: 54 YIPDVTMKILEETDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLTPDR 113 Query: 106 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 K D V FRE +E +Y G+E K + I I+ Sbjct: 114 K----LDCVCFREATEGLYTGVEAK-----------------------ITDDAAIAIRKI 146 Query: 166 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 207 + +G++RL+ +A+++A + + V K NI+K T+G F D Sbjct: 147 TRQGSRRLIDSAVDWANKFNMKKMVAVTKRNILKQTDGIFWD 188 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 74.3 bits (181), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 63/214 (29%), Positives = 100/214 (46%), Gaps = 43/214 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY--TGEKSTQVYGQDVWLPAETLDLIRE 58 IG +V A + V+D E + + IY G++ + +G LP ET+D++R+ Sbjct: 21 IGKEVMEATISVLD---------ELDVDFDYIYGIAGDECNEEHG--TPLPQETIDIVRD 69 Query: 59 YRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 + G G + V +RQE+ ++ LRPV+ Y T S ++ D +I RE Sbjct: 70 SDACLFGA----AGETAADVIVKIRQEMKMFANLRPVKSYPNTKSLFEN---VDFMIVRE 122 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E +Y AD E EE E I + + E +R++ A Sbjct: 123 NTEGLYI--------ADQE-------EET--------EDGAIAKRVITREAEERIIDYAF 159 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 212 +YA N+R VT VHK N++K T+G FK Y++ Sbjct: 160 QYAKDNNRTKVTAVHKANVLKKTDGLFKKIFYEV 193 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 74.3 bits (181), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 53/168 (31%), Positives = 76/168 (45%), Gaps = 31/168 (18%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 LP ET + I+ +K P VG + + V LR+ LDLY +RP + Y PS Sbjct: 57 LPDETFEAIKNSDACLKAP----VGESAKDVIVYLRRMLDLYANIRPAKSYPNMPS---L 109 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 + D+VI REN+ED+Y G E+ D DA + + SE Sbjct: 110 RDDVDLVIVRENTEDLYTGEEF--DIGDA----------------------AVAFRIISE 145 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + +KR+ A A VT VHK N+MK T+G F ++A + Sbjct: 146 KASKRIANYAFTIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVAND 193 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 73.9 bits (180), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 47/129 (36%), Positives = 72/129 (55%), Gaps = 14/129 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL-DLIREY 59 IG +++ +++K+ DAA K+ +E T + VY + L E+L + + Sbjct: 12 IGYEISESLVKIFDAA---------KVP-VEFETENAGSDVYEKTGELIPESLYESVERN 61 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 ++AIKGP+TTP+G G RS+NV LR++ DLY R R G + + D+ IFREN Sbjct: 62 KIAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRYDN---IDLAIFREN 118 Query: 120 SEDIYAGIE 128 +E IY G E Sbjct: 119 TEGIYIGEE 127 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 73.6 bits (179), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 96/221 (43%), Gaps = 41/221 (18%) Query: 11 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 70 ++V AA E I W ++ G ++ Q G V++ +D E V KGPLT P Sbjct: 47 EIVSAAKECIEATGVNIRWEQMDMGYEAMQNTG--VYIDDSHMDAFEEIGVLFKGPLTVP 104 Query: 71 V----------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 G S N R+ L+ +RPVR G +P D+V+ REN+ Sbjct: 105 PKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVRAPFND---VDLVVIRENT 161 Query: 121 EDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 ED+Y G E W DA+ V HC +K S ++R+ + + Sbjct: 162 EDVYTGEETW----VDADTV-----------------HC---VKRISRGASERVADFSFK 197 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ-LAREEFGG 219 YA N R VT +HK N+ K ++G F + ++ A + GG Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGG 238 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 73.6 bits (179), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 41/149 (27%), Positives = 86/149 (57%), Gaps = 13/149 (8%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++T AM+ V++A+E AY G + I W +IY G ++ + YG+ +LP E+++ IR+ Sbjct: 27 GTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGK--YLPRESIEDIRKTVF 84 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 +KGPL++ + G +N+ +++ L+LY ++ + G P + E+ IF + + Sbjct: 85 VMKGPLSSNING--HDININIKRILNLYTDVKCI---TGLPGLSEGKEI---FIFSPSID 136 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVK 150 ++Y + DS D++ + ++L++ + Sbjct: 137 EVY---HFSYDSEDSDMLRQYLQQSFNIS 162 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 73.6 bits (179), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 56/173 (32%), Positives = 76/173 (43%), Gaps = 36/173 (20%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPS 103 LPAE L+ + V +KGP TP G + S N LR+ L LY +RPVR Sbjct: 102 LPAEVLEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRI------ 155 Query: 104 PVKHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 162 PE D FREN E Y W G K I+ + + Sbjct: 156 ----PEKGIDWTFFRENIEGEYI---W------------------GNKGIQVDDDLAVDF 190 Query: 163 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 K + G +R+ RAA E+A N + +VT+V K NI+K +G F + L +E Sbjct: 191 KVLTRPGAERICRAAFEFAKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKE 243 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 71.6 bits (174), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/210 (25%), Positives = 88/210 (41%), Gaps = 37/210 (17%) Query: 16 AVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI 75 +V + + + E++ + +G+D LP T D IRE +A+K L P G G+ Sbjct: 19 SVRRLFAAAKVPVEFEVHLAGRMALEHGKDA-LPKATFDAIRECGLALKTKLLQPKGVGM 77 Query: 76 ----------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYA 125 + NVA R++L L+ +RPV G PS D ++FRE +ED+Y Sbjct: 78 PTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSRFTG---VDFLLFREITEDLYT 134 Query: 126 GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND 185 E + + K +E R + A + A Sbjct: 135 ASEHEIVPGVVQS-----------------------FKIVTEAACLRFFKLAFDTARKRG 171 Query: 186 RDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 R +V +HK NI+K +G F + Y++A+E Sbjct: 172 RKTVHCIHKANILKMADGLFLECFYRVAKE 201 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 71.6 bits (174), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/161 (31%), Positives = 80/161 (49%), Gaps = 27/161 (16%) Query: 56 IREYRVAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 I+ V +KG + T + S NVALR ELD+Y + + Y G + +H ++ D+V Sbjct: 110 IKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT--RHKDI-DVV 166 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 I R+N+E YA +E ++ + E +K + + ++R+ Sbjct: 167 IIRQNTEGEYAMLEHESVNGVVES-----------------------MKVVTADNSERVA 203 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 R A E+A N R VT VHK NIMK ++G F + +LA+E Sbjct: 204 RFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKE 244 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 70.5 bits (171), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 87/168 (51%), Gaps = 27/168 (16%) Query: 51 ETLDLIREYRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 E ++ ++ ++ +KG TP G SLNVALR++LD+Y + + +G + + P+ Sbjct: 76 EAVESLKRNKIGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI--PD 133 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 + D+++ REN+E ++G+E ++ E +K + Sbjct: 134 I-DLIVIRENTEGEFSGLEHESVPGVVES-----------------------LKVMTRPK 169 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 T+R+ R A ++A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 170 TERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY 217 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 70.1 bits (170), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 53/239 (22%), Positives = 109/239 (45%), Gaps = 35/239 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG V P ++V++A +A I W E + E + LP T+ L+R+++ Sbjct: 14 IGNQVLPQAIRVLEAVGFEANYVHADIGW-ECWCNEGNA--------LPDRTIQLLRKHK 64 Query: 61 VAIKGPLTTPV-------------GGGIRSLN--VALRQELDLYICLRPVRYYQGTP--- 102 + + G +T+ G G+ + V +RQ +L +C+RP + G P Sbjct: 65 LGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNF 124 Query: 103 ------SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 156 + P++ D+V+FR+N+E +YAG+EW + + ++ E Sbjct: 125 IRQTTCGGFEEPQV-DVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFANTP-GE 182 Query: 157 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + ++ +++ +R+ AA ++A +VT+ K N+++ T G ++ Q+ ++ Sbjct: 183 ELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQ 241 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 69.7 bits (169), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 104/227 (45%), Gaps = 47/227 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A ++V++A + W I +++ ++YG LP + + I++ + Sbjct: 11 IGPEITAATIRVIEATGIQP-------EWDFIPIADEAVRLYGHA--LPPQVIQRIKDVK 61 Query: 61 VAIKGPL----------TTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 IK PL T G + S+N A+R+EL+L++ RP+R Y G +H Sbjct: 62 FCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISG--RH 119 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 E DMVI RE +ED Y G E + A + IK + + Sbjct: 120 -EKMDMVIMREITEDTYIGWEKPLEDGAAAEAIKRV----------------------TR 156 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 157 SASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVAR 203 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 68.9 bits (167), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 37/86 (43%), Positives = 52/86 (60%), Gaps = 4/86 (4%) Query: 43 GQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP 102 GQD+ + A+ LD +R R +KGP+ TP+G G RSLN+ LR+ L LY +RP G Sbjct: 76 GQDL-ISADALDSLRRNRFGLKGPMATPIGKGYRSLNLTLRKALGLYANVRPCVSIPGVQ 134 Query: 103 SPVKHPELTDMVIFRENSEDIYAGIE 128 +P D+V REN+E Y+G+E Sbjct: 135 TPYDD---VDVVTVRENTEGEYSGLE 157 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 68.6 bits (166), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 44/144 (30%), Positives = 72/144 (50%), Gaps = 26/144 (18%) Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+KG T +G +S NV LR +LDLY + + Y P+ + D+++ REN+E Sbjct: 107 ALKGNWATSMGIDSKSYNVLLRHDLDLYANVVKFKSY---PTVITRHNNVDLIVIRENTE 163 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 Y +E + + VI+ IK +++ ++R+ + A +YA Sbjct: 164 GEYTNLEHE----NIPGVIEM-------------------IKIITKKKSERIAKYAFDYA 200 Query: 182 IANDRDSVTLVHKGNIMKFTEGAF 205 + N+R VT VHK NIMK ++G F Sbjct: 201 MENNRKKVTAVHKANIMKLSDGLF 224 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 67.0 bits (162), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 47/157 (29%), Positives = 78/157 (49%), Gaps = 26/157 (16%) Query: 48 LPAETLDLIREYRVAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 103 +P + +D +++Y + G P T P + L + +RQ+LD ++CLRP +++ G P+ Sbjct: 59 VPIDYIDQVKQYDAILLGSLGDPRTLPDYVTLEPL-IQMRQQLDQFLCLRPAKHFPGIPT 117 Query: 104 PVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 163 P+K E+ D+++ RENSE Y+ I G+ K P+ I Sbjct: 118 PLKKCEI-DILVVRENSEGEYSNIG-------------------GIFKSGTPDEFAIESA 157 Query: 164 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF 200 + G +R++R A E A R+ VTL K N MK+ Sbjct: 158 VHTRRGLERVIRYAFE-ASRKRRNHVTLATKSNAMKY 193 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 67.0 bits (162), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 54/195 (27%), Positives = 83/195 (42%), Gaps = 37/195 (18%) Query: 27 ISWMEIYTGEKSTQVYGQDVWLPAE-------TLDLIREYRVAIKGPLTTPVGG-GIRSL 78 +S +E Y G ++ + E ++ IRE +KGP+ TP G S+ Sbjct: 20 LSLLERYIGADFIEIKAGKSYFIEEGKPIEDNAIEKIRECDSLLKGPVATPTKGPSYPSV 79 Query: 79 NVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEK 138 N LR+E LY +RP R Y+G D ++ REN E +Y G W+ + D Sbjct: 80 NTLLRREFKLYANVRPFRSYEGI-----SIRRIDTILVRENLECLYYG--WEVEDEDR-- 130 Query: 139 VIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 198 I ++ ++ G +R+ A A R VT +HK NI+ Sbjct: 131 --------------------AIAMRVITKRGAERISEFAFNLAKREGRGRVTAIHKRNIL 170 Query: 199 KFTEGAFKDWGYQLA 213 K T+G F D Y++A Sbjct: 171 KRTDGLFLDAFYRVA 185 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 66.6 bits (161), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 52/177 (29%), Positives = 76/177 (42%), Gaps = 36/177 (20%) Query: 44 QDVWLPAETLDLIREYRVAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQ 99 Q+ LP L+ + + +KGP TP G + S N LR++L LY +RP+R Sbjct: 89 QNKSLPPAVLEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRI-- 146 Query: 100 GTPSPVKHPEL-TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC 158 PE D FREN E Y W G K I + Sbjct: 147 --------PEKGIDWTFFRENIEGEYI---W------------------GNKGICVGDDL 177 Query: 159 GIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 I K S+ G +RL R A EYA ++ + ++T+ K NI+K +G F + + +E Sbjct: 178 AIDFKILSKPGAERLFRNAFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKE 234 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 66.6 bits (161), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 55/167 (32%), Positives = 76/167 (45%), Gaps = 28/167 (16%) Query: 48 LPAETLDLIREYRVAIKGPLTTP-VGGGI--RSLNVALRQELDLYICLRPVRYYQGTPSP 104 LP + ++ ++ Y G + P V GI + + + LR ELD YI LRPV+ Y G +P Sbjct: 69 LPPDAVEQLKRYDAIYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKLYPGVETP 128 Query: 105 V--KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 162 + K PE D V+ REN+E +YAG G K P+ I Sbjct: 129 IAGKGPEDIDFVVVRENTEGLYAG-------------------SGGFLKRGTPDEVAIQT 169 Query: 163 KPCSEEGTKRLVRAAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDW 208 + +G +R VR A EY R VTL K N++ F AF W Sbjct: 170 SINTRKGVERCVRFAFEYCRKRGGRRKVTLCGKTNVLTF---AFDLW 213 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 66.2 bits (160), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 51/166 (30%), Positives = 80/166 (48%), Gaps = 30/166 (18%) Query: 44 QDVWLPA--ETLDLIREYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQ 99 +D +L A E + I+ VA+KG + TP+ G RSLN+ LR LDL+ + + Sbjct: 95 EDSYLGAFNEAITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIP 154 Query: 100 GTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 159 G + +H + D+VI R+N+E Y+ +E + S E Sbjct: 155 GIQT--RHNNV-DLVIIRQNTEGEYSHLEHENVSGVIEN--------------------- 190 Query: 160 IGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 +K +EE ++ + A ++A +DR VT VHK NIMK +G F Sbjct: 191 --LKVTTEEACMKIAQYAFDFAEKHDRKKVTAVHKANIMKMGDGLF 234 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 65.5 bits (158), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 42/156 (26%), Positives = 83/156 (53%), Gaps = 27/156 (17%) Query: 61 VAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + +KG +TT + +S+N +R++LDLY + P + G + +H ++ D+V+ REN Sbjct: 142 IGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGVWT--RHGQV-DLVVIREN 198 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y +E + + + V++ L K +E+ ++R+ + A + Sbjct: 199 TEGEYGSLEHE----NVDGVVESL-------------------KIITEKKSRRIAKFAFD 235 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 YA+ N+R VT +HK NIMK +G F + +++++ Sbjct: 236 YALQNNRRKVTAIHKANIMKLADGLFLETCREISKD 271 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 65.5 bits (158), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 53/189 (28%), Positives = 81/189 (42%), Gaps = 34/189 (17%) Query: 27 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 86 I + E+ ++S D L ++ V IKG T G R NVALR L Sbjct: 98 IDFEEVAVNQESEDATFTDALLA------MKRNGVGIKGNFATEPGQSSR--NVALRLNL 149 Query: 87 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 146 +LY ++ R + P V + D+VI REN+E Y+ +E + E Sbjct: 150 NLYAFVQRCRNF---PGVVTRHQNVDIVIIRENTEGEYSRLEHENVPGVVES-------- 198 Query: 147 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 206 +K + E + R+ + A +YA+ ++R VT VHK NIMK +G F Sbjct: 199 ---------------LKIITREKSTRIAQFAFDYAVRHNRKKVTAVHKANIMKLGDGLFL 243 Query: 207 DWGYQLARE 215 D +A+ Sbjct: 244 DVCSSIAKN 252 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 64.7 bits (156), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/164 (31%), Positives = 80/164 (48%), Gaps = 29/164 (17%) Query: 56 IREYRVAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTPS-PVKHPELTDM 113 I+ VAIKG + T I +S NV LR+ LDL+ V + P+ P +H + ++ Sbjct: 99 IQRNGVAIKGNIETKYDDPIFKSRNVELRRRLDLF---ANVLHCVSIPTIPTRHKGI-NI 154 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 V+ REN+E Y+G E + + E +K C+ E +R+ Sbjct: 155 VMIRENTEGEYSGHEHETVNGVVES-----------------------LKICTREKLERI 191 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R A +YAIA++R +T VHK NI K +G F ++A +E+ Sbjct: 192 SRFAFDYAIAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEY 235 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 64.7 bits (156), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 45/166 (27%), Positives = 77/166 (46%), Gaps = 27/166 (16%) Query: 51 ETLDLIREYRVAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 E L IR RVA+KG + I+S N+ R+ LDL++ + + + G + K E Sbjct: 87 EALTSIRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLSN--KFGE 144 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 + D+ + R+N+E Y +E + + E +K + Sbjct: 145 I-DITVIRQNTEGEYLMLEHEPRTGSVE-----------------------SLKVLTRFN 180 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 +RL+ A +YA+ NDR +T+VH NI K TEG F + ++++ Sbjct: 181 LERLIEFAFDYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKS 226 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 63.9 bits (154), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 56/183 (30%), Positives = 85/183 (46%), Gaps = 43/183 (23%) Query: 48 LPAETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 105 LP+ TL R + G + +P G RS V LR+ELDLY +RPV + P Sbjct: 54 LPSATLTAARAADAILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPV--FDDLPENG 111 Query: 106 KHPEL--TDMVIFRENSEDIYAG---IEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 160 +P D+V+ REN+ED+YAG +E +A AE+VI Sbjct: 112 SNPRRRKVDLVVVRENTEDVYAGRERVEDDGATAIAERVI-------------------- 151 Query: 161 GIKPCSEEGTKRLVRAAIEYAIA-----NDRDS----VTLVHKGNIMKFTEGAFKDWGYQ 211 + + R++R A + A A N D+ VT+VHK N+++ T G F+ + Sbjct: 152 -----TRRASARIMRVACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALE 206 Query: 212 LAR 214 +A+ Sbjct: 207 VAQ 209 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 63.9 bits (154), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 112/230 (48%), Gaps = 42/230 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREY- 59 IG +V PA +V++ K +++++Y G ++ Q G+ LP ET+ +++E Sbjct: 34 IGKEVIPAGKQVLE---NLNSKHGLSFNFIDLYAGFQTFQETGK--ALPDETVKVLKEQC 88 Query: 60 RVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPS-PVKHPELTDMVIF 116 + A+ G + +P G S VALR+E+ L+ +RPV+ +G P+ DMVI Sbjct: 89 QGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEGEKGKPI------DMVIV 142 Query: 117 RENSEDIYAGIEWK-ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+ED+Y IE D A +V K SE T+R+ Sbjct: 143 RENTEDLYIKIEKTYIDKATGTRVAD-------------------ATKRISEIATRRIAT 183 Query: 176 AAIEYAI----ANDRDSVTLVHKGNIMKFTEGAFKDWG---YQLAREEFG 218 A++ A+ + ++T+ HK N++ ++G F++ Y+ ++++G Sbjct: 184 IALDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYG 233 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 63.2 bits (152), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 65/219 (29%), Positives = 104/219 (47%), Gaps = 28/219 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ PA +K++DAAV A I+W E+ G + YG+ P +TLD + E Sbjct: 34 IGPEIVPASVKILDAAVAAAGA--TPIAWTELPLGRSAIDEYGEHT--PTKTLDALDEVD 89 Query: 61 VAIKGPLTTPV-GGGIRS-LNVA--LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + GP + RS LN + +R+ L+ +RP + ++G + V E TD+VI Sbjct: 90 GWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNAIV---EGTDLVIV 146 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA A + E M + GI + T+R+ Sbjct: 147 RENTEGFYADRNTFAGTG----------EMMPTPDVAIMH--GI----ITRAATERIAHE 190 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A + A D+ VT+VHK N++K T G F+D ++ ++ Sbjct: 191 AFQLARTRDK-RVTIVHKANVLKMTTGLFRDVCREVGKQ 228 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 63.2 bits (152), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 53/183 (28%), Positives = 86/183 (46%), Gaps = 35/183 (19%) Query: 34 TGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLR 93 G+++ + YG+ LP ETL+ R+ + G G + V LR+EL + +R Sbjct: 38 AGDEALEKYGK--ALPDETLEACRKSDAVLFGA----AGETAADVIVRLRRELGTFANVR 91 Query: 94 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK-ADSADAEKVIKFLREEMGVKKI 152 P + +G +P L D+V+ REN+E +Y G E+ D +A +VI Sbjct: 92 PAKAIEGIEC--LYPGL-DIVVVRENTECLYMGFEFGFGDVTEAIRVI------------ 136 Query: 153 RFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 212 + E ++R+ R A E A R VT +HK N+MK T G F+D ++ Sbjct: 137 -------------TREASERIARYAFELAKREGRKKVTALHKANVMKKTCGLFRDVCREV 183 Query: 213 ARE 215 A++ Sbjct: 184 AKD 186 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 63.2 bits (152), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 36/109 (33%), Positives = 58/109 (53%), Gaps = 7/109 (6%) Query: 24 ERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPV---GGGIRSLNV 80 E I+W ++ G +G +PA+ +D++R + + G + P + L + Sbjct: 27 ELGIAWTDVPWGSAWWAEHG--TMMPADAIDVLRGHDAILMGAVGDPAVPDDEALWGLIL 84 Query: 81 ALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVIFRENSEDIYAGI 127 +RQELDL++ +RP R +G P P+ + P DMV RENSE YAG+ Sbjct: 85 KIRQELDLWVNVRPARLLEGIPGPLAGRAPHDVDMVFVRENSEGEYAGV 133 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 62.8 bits (151), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 51/174 (29%), Positives = 75/174 (43%), Gaps = 29/174 (16%) Query: 48 LPAETLDLIREYRVAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSP 104 L LD IR A+ G + P G +R + LR ELDLY+ RP R + SP Sbjct: 69 LTGSDLDRIRSSEAALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSP 128 Query: 105 VKHP--ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 162 ++ P D VI REN+E +Y+GI G + PE + + Sbjct: 129 LRDPARRAIDCVIVRENTEGLYSGIG-------------------GGARTGTPEEIAVDV 169 Query: 163 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD-WGYQLARE 215 + G R+ +E+A + R SV LV K N ++ ++ WG +AR Sbjct: 170 DLSTRHGVSRV----LEFAFSAARRSVCLVDKANAVRNGGQLWQRCWGEAVARH 219 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 62.8 bits (151), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 110/226 (48%), Gaps = 42/226 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERK---ISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 57 IG +V PA ++V++AA+ K K ++ + ++ + G ++ Q G+ LP ET++ ++ Sbjct: 42 IGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKS--LPVETVEALK 99 Query: 58 -EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVR-YYQGTPSPVKHPELTDM 113 + AI G + +P G S VA+R+ +DLY +RP + +G DM Sbjct: 100 NKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPCQDLAKGI----------DM 149 Query: 114 VIFRENSEDIYAGIE-WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 +I REN+E +Y E D EK + + +E +KR Sbjct: 150 LIVRENTECLYIKKEKLTVDPTTGEKT-------------------AVADRLITERASKR 190 Query: 173 LVRAAIEYAIANDRD---SVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + A + A+ +++ VT+VHK N++ ++G F++ +++++ Sbjct: 191 IAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKK 236 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 47/161 (29%), Positives = 73/161 (45%), Gaps = 26/161 (16%) Query: 56 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMV 114 I +V +KGP T +S++ L + LY + PV+ Q P V P DMV Sbjct: 136 ILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPFRDVDMV 193 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + REN+E Y+G+E + E +K + +G+ R+ Sbjct: 194 VVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRDGSMRIA 230 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + A EYA + R V +HK NIMK ++G F + Q+A+E Sbjct: 231 KWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKE 271 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 47/133 (35%), Positives = 58/133 (43%), Gaps = 23/133 (17%) Query: 71 VGGGI--RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIE 128 + GGI R L + LR D YI LRP G SP+ P D V+ RE +E YAG Sbjct: 84 LAGGIIERGLLLKLRFAFDHYINLRPTALLPGVASPLAAPGQVDFVVVREGTEGPYAG-- 141 Query: 129 WKADSADAEKVIKFLREEMGVKKIRFPEH-CGIGIKPCSEEGTKRLVRAAIEYAIANDRD 187 GV + R EH + + G +R VR A E A DR Sbjct: 142 -----------------NGGVLR-RGTEHEIATEVSVNTAHGVERTVRFAFELAEKRDRK 183 Query: 188 SVTLVHKGNIMKF 200 VTLVHK N++ F Sbjct: 184 RVTLVHKTNVLTF 196 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 60.8 bits (146), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 48/161 (29%), Positives = 78/161 (48%), Gaps = 27/161 (16%) Query: 56 IREYRVAIKGPL-TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 IR VA+KG + TT + N+ LR +L+LY+ + R + G + KH + D+V Sbjct: 101 IRRNGVALKGNIETTSYSMTVEPRNLLLRNKLELYVNVVHCRNHPGINT--KHKGV-DIV 157 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + R+N+E Y+ +E + S V++ L+ K + ++C Sbjct: 158 VIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYC---------------- 197 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 EYA + R VT+VHK NIMK T+G F ++A+E Sbjct: 198 ---FEYARTHMRKKVTVVHKANIMKLTDGLFLKTCTEVAQE 235 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 60.5 bits (145), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 100/222 (45%), Gaps = 49/222 (22%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA +V++A + ++E G ++ + G V P ET++ I Sbjct: 13 IGHEVIPAARRVLEAT-------GLPLEFVEAEAGWETFERRGTSV--PEETVEKILSCH 63 Query: 61 VAIKGPLTTPVG------GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 + G T+P G IR L R+ LDLY +RP + P P P + D+V Sbjct: 64 ATLFGAATSPTRKVPGFFGAIRYL----RRRLDLYANVRPAK---SRPVPGSRPGV-DLV 115 Query: 115 IFRENSEDIYAGIEWK-ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 I REN+E +Y E + D A A+ VI S++ ++R+ Sbjct: 116 IVRENTEGLYVEQERRYLDVAIADAVI-------------------------SKKASERI 150 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 RAA+ A R ++ + HK N++ T+G F D ++A++ Sbjct: 151 GRAALRIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKD 192 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 60.1 bits (144), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 48/157 (30%), Positives = 78/157 (49%), Gaps = 28/157 (17%) Query: 51 ETLDLIREYRVAIKGPLTTPV--GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 108 + L ++E +VAI G + TP+ G + S ++ LR++LDL+ + V+ G + +H Sbjct: 99 QVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT--RHN 156 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 L D+VI RE +E Y+ +E ++ A VI+ L K + Sbjct: 157 NL-DLVIIREQTEGEYSSLEHES----ARGVIECL-------------------KIVTRA 192 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 ++R+ + A +YA R VT VHK NIMK +G F Sbjct: 193 KSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLF 229 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 59.3 bits (142), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 60/202 (29%), Positives = 103/202 (50%), Gaps = 24/202 (11%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR-EY 59 IG +V PA ++++A +Y G K + +++ G ++ + G LP +T++++R E Sbjct: 16 IGKEVIPAGRRILEAL--PSYLG-LKFEFTDLHAGFETFERTG--AALPDKTVEILRNEC 70 Query: 60 RVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 A+ G +++P G S VALR++LDLY +RPV+ P+ DMVI R Sbjct: 71 DGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTVLSAAKPI------DMVIVR 124 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG-IGIKPCSEEGTKRLVRA 176 EN+ED+Y E D+ D KV + ++ R G I ++ ++ +RA Sbjct: 125 ENTEDLYVKEETTRDTPDG-KVAEAIKRISERASHRIATMAGDIALR-------RQKIRA 176 Query: 177 AIEYAIANDRDSVTLVHKGNIM 198 A +I + VT+ HK N++ Sbjct: 177 AGAPSI-HQSPLVTITHKSNVL 197 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 57.0 bits (136), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 40/129 (31%), Positives = 57/129 (44%), Gaps = 21/129 (16%) Query: 76 RSLNVALRQELDLYICLRPVRYYQGTPSPVK--HPELTDMVIFRENSEDIYAGIEWKADS 133 R + +R DLY +RPVR P+K + D V+FREN+E IY G+ Sbjct: 91 RDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFRENTEGIYVGMG----- 145 Query: 134 ADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVH 193 G K P+ I + +G +R++RAA +YA AN R VT+ Sbjct: 146 --------------GQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMAD 191 Query: 194 KGNIMKFTE 202 K N M+ Sbjct: 192 KSNAMRHAH 200 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 56.6 bits (135), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 56/204 (27%), Positives = 87/204 (42%), Gaps = 30/204 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + + AA+E G R + GE+ + Q +P + DL+++ Sbjct: 18 IGPEVVAATVPALRAALEA--DGHRLDVTSFDWGGERYLR---QGAAMPPDAADLVKKTD 72 Query: 61 VAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P + L + LRQ+LDL + LRPVR + G P+ V+ + D+VI R Sbjct: 73 AVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDTDGVDLVIVR 132 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+E Y G GV GI + S +R A Sbjct: 133 ENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRRAIERAAHQA 173 Query: 178 IEYAIANDRDS-VTLVHKGNIMKF 200 +A+A R + LV K N M++ Sbjct: 174 --FALAGRRSGRLCLVTKSNAMRY 195 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 56.2 bits (134), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 47/154 (30%), Positives = 69/154 (44%), Gaps = 22/154 (14%) Query: 48 LPAETLDLIREYRVAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSP 104 LP LD +R + + G + + P G R L + LR ELD ++ LRP R + G SP Sbjct: 49 LPDTVLDELRRHDAILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSP 108 Query: 105 VKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP 164 + P DM+ RE +E Y G GV + P + Sbjct: 109 LAAPGAIDMLCVREGTEGPYVG-------------------NGGVLRRDTPHEVATEVSL 149 Query: 165 CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 198 + G +R+VR A E A+A R +TL+HK N++ Sbjct: 150 NTAFGVERVVRYAFERALARPRRHLTLIHKTNVL 183 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 56.2 bits (134), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 48/174 (27%), Positives = 76/174 (43%), Gaps = 35/174 (20%) Query: 44 QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS 103 + V LP ETL+ + L +G R + + LRQ+LDLY+ LRP + Y P Sbjct: 50 RGVALPEETLNGVMNS----DATLMVAIGESAREVILPLRQKLDLYVNLRPAKSY---PV 102 Query: 104 PVKHPELTDMVIFRENSEDIYAGIEWKA-DSADAEKVIKFLREEMGVKKIRFPEHCGIGI 162 P P D+ I REN+ED+Y W+ D+A ++I Sbjct: 103 PRAIPGF-DLTIVRENTEDLYVMSGWRGLDTAVDLRII---------------------- 139 Query: 163 KPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + ++R+ R YA + V +VHK N++ F++ ++A EE Sbjct: 140 ---TRRASERICRFGYRYARERGKSRVYVVHKANVLGGCM-LFREVCSRVAEEE 189 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 56.2 bits (134), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 91/203 (44%), Gaps = 27/203 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++V A ++VV+ + G I + I G + +G+ ++ + LD +R++ Sbjct: 57 IGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVSEDCLDTLRKFD 112 Query: 61 VAIKGPLTTP-VGGGIR--SLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMVIF 116 + G + P V I L +ALR L LY +RPVR + GT P+ E D ++ Sbjct: 113 AGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLNTATEGIDWMLV 172 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RENSE Y+G + G + P + + G +R++R Sbjct: 173 RENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMFTRVGIERIMRF 213 Query: 177 AIEYAIANDRDSVTLVHKGNIMK 199 A E A + R +T+V K N M+ Sbjct: 214 AFEVAQSRPRKLLTVVTKSNSMR 236 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 101/220 (45%), Gaps = 31/220 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++V++AA K ++ + +I G S Q +G V PA L+ ++ Sbjct: 11 IGPEIMAVAVRVLEAA-SKRFQLDLEIG--HDIAGHASLQRHGATVT-PA-LLEKVKAAD 65 Query: 61 VAIKGPLTT-----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 + GP+ T G I R+ELDLY +RP R + G V ++ + Sbjct: 66 GLMLGPMATYDFKDEAKGEINPSKF-FRKELDLYANIRPARTFPGMAHRVGE---FNLAV 121 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E YA + +S +E +I P+ I ++ + +R+ R Sbjct: 122 VRENTEGFYA--DRNIESGSSEMLIT-------------PDTV-ISLRRITRLCCERIAR 165 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 +A + A R V++VHK N++K +G F D Q+ARE Sbjct: 166 SAFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVARE 204 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 55.5 bits (132), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 49/179 (27%), Positives = 81/179 (45%), Gaps = 35/179 (19%) Query: 27 ISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQEL 86 I W +++ K G+DV + L+ + ++ IKGP + G +R L R++ Sbjct: 16 IDW-DVFHEHKINSAEGEDV--SPKLLESLCRNKIGIKGPFES--GPCLRKL----RKKF 66 Query: 87 DLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 146 L+ + R +G + ++ +L D +I R+ E Y+GIE + Sbjct: 67 QLFAFVAVCRNLEGQNT--RYGKL-DCLIIRDQVEGEYSGIEHRVVP------------- 110 Query: 147 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 GV + IK + EG R+ R EYA N+R +T+ HK NIM+ T+G F Sbjct: 111 -GVMQT---------IKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLTDGTF 159 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 53.9 bits (128), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 85/213 (39%), Gaps = 38/213 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + V+ A E + S+ E G+ + G LP T + + Sbjct: 17 IGQEVIPAAVAVLQAVDEVGF------SFTEKQAGDDTRDQTG--AALPETTYEAAADAD 68 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + + LR+ + ++ +RP R Y G + PE TD+V REN+ Sbjct: 69 ATLFGA----AGETAADVILPLREAVGSFVNIRPARAYPGVDA--LQPE-TDLVFLRENT 121 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+G E R E + + +++L A Y Sbjct: 122 EGVYSGHED-----------------------RLSEDLSTLTRVITTSASEQLAEYACSY 158 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 D VHK N+M+ T+G F+D ++A Sbjct: 159 VTERSIDGFHTVHKANVMQETDGRFRDAVSRVA 191 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 53.5 bits (127), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 30/129 (23%), Positives = 66/129 (51%), Gaps = 6/129 (4%) Query: 76 RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM--VIFRENSEDIYAGIEWKADS 133 + + + +R D Y+ LRPV+ +G +P+K D+ + REN+ED Y GI ++ Sbjct: 88 KGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAADIDFYVVRENTEDFYVGIGGRSKK 147 Query: 134 ADAEKVIKFLRE----EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSV 189 +++ ++ +R+ + G+ + + S+EG KR++ + + A + + + Sbjct: 148 GTSKQELEVIRQMYSVKFGLDVETDSDEIAYQLGVVSKEGAKRIIEYSFDLANSRPKKHL 207 Query: 190 TLVHKGNIM 198 + V K N++ Sbjct: 208 SSVDKANVL 216 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 52.0 bits (123), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 73/160 (45%), Gaps = 28/160 (17%) Query: 56 IREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 IR RVA+KG + T + +S N LR LDLY V +++ P V + D+ Sbjct: 23 IRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYA---NVIHWKSLPGVVTRHKDIDI 79 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 +I REN+E Y+ +E ++ + V++ L+ K +R E+ K E G K+ Sbjct: 80 LIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEY---AFKLAQESGRKK- 131 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 VT VHK NIMK +G F ++A Sbjct: 132 ---------------VTAVHKANIMKLGDGLFLQCCREVA 156 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 52.0 bits (123), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 57/232 (24%), Positives = 97/232 (41%), Gaps = 37/232 (15%) Query: 1 IGVDVTPAMLKVVDAA----------VEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA 50 IG +VT +KV++AA Y E +S ++ ++ G D L Sbjct: 14 IGPEVTAQAVKVMEAAGSLFGFSLELTHYPYGAEHYLSTRQVLPDHALEEMEGLDALLLG 73 Query: 51 ETLDLIREYRVAIKGPLTTPVGGGI--RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 108 AI P P GI R + + LR D Y +RPVR + TP P+ Sbjct: 74 -----------AIGDPRVQP---GILERGILLKLRFHFDQYANIRPVRSF--TPGPLGS- 116 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSA-----DAEKVIKFLREEMGVKKIRFPEHCGIGIK 163 + V+ REN+ED+Y GI D A + + ++ ++ P+ + + Sbjct: 117 --VNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTP-PKRFAMQVA 173 Query: 164 PCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + +G R + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 174 WHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQ 225 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 51.6 bits (122), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 94/218 (43%), Gaps = 28/218 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLP---AETLDLIR 57 IG ++ P ++V+ AA A + I W +I G + G LP E LD + Sbjct: 11 IGHEIVPEAVRVMQAA---AARTGLAIEWQDIPIGRAALDSLGST--LPDGTIERLDALD 65 Query: 58 EYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + + G + P + + LR+ DL+ +RPV+ + P H + D+VI R Sbjct: 66 GWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAAL--PCLH-QGVDLVIVR 122 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+E ++ D V+ G + R I ++ + G+ ++ RAA Sbjct: 123 ENNEG------FQPD----RNVVA------GSGEFRPTPDVTISVRVITRNGSSKVARAA 166 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 E A A R +T VHK + K G F + +LA E Sbjct: 167 FELARAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAE 203 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 51.2 bits (121), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 72/160 (45%), Gaps = 28/160 (17%) Query: 56 IREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 IR RVA+KG + T + +S N LR LDLY V + + P V + D+ Sbjct: 69 IRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLY---ANVIHCKSLPGVVTRHKDIDI 125 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 +I REN+E Y+ +E ++ + V++ L+ K +R E+ K E G K+ Sbjct: 126 LIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEY---AFKLAQESGRKK- 177 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 VT VHK NIMK +G F ++A Sbjct: 178 ---------------VTAVHKANIMKLGDGLFLQCCREVA 202 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 47/160 (29%), Positives = 72/160 (45%), Gaps = 28/160 (17%) Query: 56 IREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 IR RVA+KG + T + +S N LR LDLY V + + P V + D+ Sbjct: 107 IRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLY---ANVIHCKSLPGVVTRHKDIDI 163 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 +I REN+E Y+ +E ++ + V++ L+ K +R E+ Sbjct: 164 LIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEY---------------- 203 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 A + A + R VT VHK NIMK +G F ++A Sbjct: 204 ---AFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVA 240 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 48/216 (22%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV-WLPAETLDLIREY 59 I +VT A+ +V+DA Y E Y + G+++ L E +D IR+ Sbjct: 8 IDSNVTNAVHQVMDAMQAPVY--------FETYI------IKGKNMNHLTWEVVDSIRKN 53 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +V + G + + GG R+ELDL+ L G PS +H E D+V+ REN Sbjct: 54 KVCLNGRVNNSLCGG-------ARKELDLFASLVDCFNLNGQPS--RH-ENVDIVVIREN 103 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E YAG E +V+ + E V +F + R+ + A E Sbjct: 104 TEGEYAGRE--------HEVVPGVIESFQVTMTKF--------------WSDRIAKYAFE 141 Query: 180 YAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAR 214 YA + R VT VH G K + F + ++A+ Sbjct: 142 YAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAK 177 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 50.8 bits (120), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 44/130 (33%), Positives = 63/130 (48%), Gaps = 8/130 (6%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A ++V+DA E + R ++EI G + + G A+ L E Sbjct: 14 IGPEIVEATVRVLDALAEL-HPESRGWEYVEIDAGADTYRRTGV-ACAEADVRRLRDEVD 71 Query: 61 VAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 +KGP+ TP G L LR LD Y +RPVR + G PS V+ + D VI Sbjct: 72 ATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRVR-ADRVDYVI 130 Query: 116 FRENSEDIYA 125 REN+E +YA Sbjct: 131 VRENTEGLYA 140 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 50.8 bits (120), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/135 (28%), Positives = 60/135 (44%), Gaps = 21/135 (15%) Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+ P P + L + +R+EL+L I +RP + G SP+ HP D V+ RENSE Sbjct: 77 AVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLLHPNDFDFVVIRENSE 136 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 Y+ + + D +E+ ++ F + + T+R++R A E A Sbjct: 137 GEYSEVGGRIHRGD---------DEIAIQNAVF-----------TRKATERVMRFAFELA 176 Query: 182 IANDRDSVTLVHKGN 196 R VT K N Sbjct: 177 -KKRRSHVTSATKSN 190 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 50.4 bits (119), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 96/213 (45%), Gaps = 36/213 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ PA +KV+DA + K ++ + T + D L+ I+ Sbjct: 11 IGREIIPAAVKVLDAFGLEFEKVPLELGYTRWE--RTGTAISNND-------LETIKGCD 61 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G +TT +S+ + +R+ELDLY +RPV+ G + D +I REN+ Sbjct: 62 AVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGVTGRNDF-DFIIVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+GIE E+G PE + + +G++R+ A + Sbjct: 121 EGLYSGIE-----------------EIG------PELSWTK-RVVTRKGSERIAEYACKL 156 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 A ++ +T+VHK N++K ++ F D Q A Sbjct: 157 A-KKRKNKLTIVHKSNVLK-SDKLFLDVCRQTA 187 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 50.1 bits (118), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 41/131 (31%), Positives = 64/131 (48%), Gaps = 12/131 (9%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV-WLPAETLDLIREY 59 IG +V PA L++V+AA A G +++ T Q Y + LPA TLD R+ Sbjct: 18 IGREVMPACLELVNAATTMA--GAPALAFQ---THNAGAQYYAESGDALPASTLDACRKS 72 Query: 60 RVAIKGPLTTP---VGGGIRSL-NVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDM 113 + G + P G + + LR EL L+ +RP+R++ G P + P E D Sbjct: 73 DAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPRAEQIDF 132 Query: 114 VIFRENSEDIY 124 V+ RE +E ++ Sbjct: 133 VLVREQTEGLF 143 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 49.7 bits (117), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 40/155 (25%), Positives = 64/155 (41%), Gaps = 32/155 (20%) Query: 51 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 110 E L +R +V IKGP+ + R +R++ + + + +G SP Sbjct: 135 EVLKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGD--- 185 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+VI R+ E Y+GIE V+ + + IK + G Sbjct: 186 FDVVIIRDQMEGDYSGIE--------HLVVPGVMQT---------------IKVSTTAGA 222 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 R+ YA+ N R +T+ HK NIM+ T+G F Sbjct: 223 ARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 257 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 49.7 bits (117), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 40/155 (25%), Positives = 64/155 (41%), Gaps = 32/155 (20%) Query: 51 ETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 110 E L +R +V IKGP+ + R +R++ + + + +G SP Sbjct: 34 EVLKSLRANKVGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPYGD--- 84 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+VI R+ E Y+GIE V+ + + IK + G Sbjct: 85 FDVVIIRDQMEGDYSGIE--------HLVVPGVMQT---------------IKVSTTAGA 121 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 R+ YA+ N R +T+ HK NIM+ T+G F Sbjct: 122 ARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNF 156 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 49.3 bits (116), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 87/203 (42%), Gaps = 33/203 (16%) Query: 1 IGVDVTPAMLKVVDAAVEK-AYKGERKISWMEIYTGEKSTQVY-GQDVWLPAETLDLIRE 58 IG +V P ++V++AA K +K + T + S Y Q +P++ ++ +R+ Sbjct: 17 IGNEVVPEGIRVLEAASAKFGFK-------LAFTTYDWSCARYHSQGSMMPSDGIERLRD 69 Query: 59 YRVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDM 113 G + P + +L + +R+E D Y+ LRPVR G P P+ K P D Sbjct: 70 SDAIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANKKPGDIDF 129 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 I REN+E Y+ + ++ E ++ F + GT R+ Sbjct: 130 WIVRENTEGEYSQV--------GGRMFAGTEHEFVTQEAIF-----------TRRGTDRI 170 Query: 174 VRAAIEYAIANDRDSVTLVHKGN 196 +R A + A R+ VT K N Sbjct: 171 MRYAFDLAKKLGRNHVTSATKSN 193 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 49/213 (23%), Positives = 90/213 (42%), Gaps = 45/213 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA V++A K ++E G ++ + G V P TL+ + Sbjct: 15 IGHEVIPAARLVLEAT-------GLKFEFVEAQAGWETFERIGTSV--PEATLEAVTHTD 65 Query: 61 VAIKGPLTTPVG------GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 + G T+P G IR + R++LDL+ +RP +++ P P P + D++ Sbjct: 66 ATLFGAATSPTKKVPGFFGAIRYM----RRKLDLFANVRPAKHH---PVPGSRPGV-DLI 117 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + REN+E +Y E+ +L E+ + + + + R+ Sbjct: 118 VVRENTEGLYV-----------EQERSYLEGEIAIADTVI-----------TRKASARIG 155 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD 207 A A + R + + HK N++ T+G F + Sbjct: 156 EYAARLAASRPRKQLHVAHKANVLPMTQGLFMN 188 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 48.9 bits (115), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 92/220 (41%), Gaps = 28/220 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A ++V+ +A + +K + + ++ G S + YG L E L + Y Sbjct: 11 IGPEIVGAAMEVLRSA-DSVFKLDLAFDYDDV--GFTSLEKYG--TTLRDEVLAKAKTYD 65 Query: 61 VAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 I G + P GG R+++ R LDLY +RP R S ++ D+VI Sbjct: 66 GVILGTQSHADYPAPDKGG-RNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTMDLVI 124 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RE +E Y A+ +M + + HC ++R+ R Sbjct: 125 MREATEGFYPDRNMTKGWAEL-----MPSPDMAISLRKITRHC-----------SERIAR 168 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A E A+ + VT +HK N T+G F + +AR+ Sbjct: 169 RAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARD 207 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 48.5 bits (114), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 71/175 (40%), Gaps = 24/175 (13%) Query: 46 VWLPAETLDLIREYRVAIKGPLTTP-VGGGIR--SLNVALRQELDLYICLRPVRYYQGTP 102 V +PA+ L+ +R+ + G P + I L + + Q LD Y +RP R G Sbjct: 55 VMMPADGLEPLRDKDAILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGID 114 Query: 103 SPVKH--PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGI 160 P+K E D VI RENSE Y+G+ + P Sbjct: 115 GPLKRCTAEQLDWVIVRENSEGEYSGVGGRVHQG-------------------LPIEAAT 155 Query: 161 GIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + + G +R++R A A + R +T+V K N + + + +++RE Sbjct: 156 DVSMMTRAGVERILRYAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISRE 210 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 48.1 bits (113), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/114 (29%), Positives = 49/114 (42%), Gaps = 21/114 (18%) Query: 89 YICLRPVRYYQGTPSPVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREE 146 Y+ LRPVR Y G +P+ PE DM++ RE +E YAG+ Sbjct: 102 YVNLRPVRLYPGVTTPLAGVAPEDIDMLVVREGTEGPYAGMG------------------ 143 Query: 147 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF 200 GV + P + G +R+VR A A +TLVHK N++ + Sbjct: 144 -GVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERPCHKLTLVHKDNVLTY 196 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 47.8 bits (112), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 56/194 (28%), Positives = 81/194 (41%), Gaps = 47/194 (24%) Query: 11 KVVDAAVE--KAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLT 68 +V+D AV KA G + + E G Q G + E L+ IR + G T Sbjct: 15 EVIDGAVRVLKAVTGRVRFEYYE--GGVDVFQECGSPIR--EEDLEEIRRSDAVLFGATT 70 Query: 69 TPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT---DMVIFRENSEDIY 124 TP G RSL + LR+EL LY LR + P+L ++VI RENSE +Y Sbjct: 71 TPFDLPGYRSLILTLRKELGLYANLRII------------PDLRTGREIVIVRENSEGLY 118 Query: 125 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAN 184 GI + + ++ + EG +R+ R A+E A A Sbjct: 119 FGIGAVVNGR------------------------AVDVRLITREGAERIARFAVEQAKAR 154 Query: 185 DRDSVTLVHKGNIM 198 +T VHK N++ Sbjct: 155 G-SFITFVHKANVL 167 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 47.8 bits (112), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 88/210 (41%), Gaps = 40/210 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD------VWLPAETLD 54 IG +V A L+V++A E++ I+T T +G D V +PA+ L+ Sbjct: 14 IGPEVIAAGLQVLEAL-------EKRSGDFSIHT---ETFDWGSDYYKKNGVMMPADGLE 63 Query: 55 LIREYRVAIKGPLTTP-VGGGIR--SLNVALRQELDLYICLRPVRYYQGTPSPVKH--PE 109 ++++ G + P V I L + + Q D Y +RP + G P+++ P Sbjct: 64 QLKKFDAIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGPG 123 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D VI RENSE Y+G +A PE G + + G Sbjct: 124 DLDWVIVRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVAIFTRVG 164 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMK 199 R++R A + A A R +T+V K N + Sbjct: 165 VTRIMRYAFKLAQARPRKLLTVVTKSNAQR 194 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 47.0 bits (110), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 50/188 (26%), Positives = 76/188 (40%), Gaps = 31/188 (16%) Query: 1 IGVDVTPAMLKVVDAAVEK-----AYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDL 55 IGV+V P L+ +DA + AY+ I W K Q+ D +D Sbjct: 51 IGVEVMPEGLRALDAVSRRFGLRFAYE---PIEWASCDYYAKHGQMMPDDWKTQLSGMDA 107 Query: 56 IREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDM 113 + A+ P T P + + R+E D Y+ LRP R + G P P+ + D Sbjct: 108 L--LFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDIDF 165 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 +I REN+E Y SA + + E V++ F H GT+R+ Sbjct: 166 MIVRENTEGEY--------SAVGGTMFEGTEREFVVQQAVFTRH-----------GTERV 206 Query: 174 VRAAIEYA 181 ++ A E A Sbjct: 207 LKFAFELA 214 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 46.2 bits (108), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 41/129 (31%), Positives = 66/129 (51%), Gaps = 13/129 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++ V+ A++ + GE ++ + G ++ G+ V P ET + I Sbjct: 17 IGPEIVAPTVQAVELALQAS--GEATPEFVPLLLGREAINATGRIV--PEETWETITGLD 72 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 I GP P G + + LR++ DL+ +RPVR G P V HP+L D+VI Sbjct: 73 GWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVR---GVPGAV-HPDL-DVVIV 127 Query: 117 RENSEDIYA 125 REN+E +YA Sbjct: 128 RENTEGMYA 136 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 46.2 bits (108), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 85/206 (41%), Gaps = 33/206 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGER-KISWMEIYTGEKSTQVYGQDVWLPAETLDLIREY 59 IGVDVT A ++V+ AA + + + W Y E +P + ++ +R + Sbjct: 14 IGVDVTDAAMEVLGAAAKGRFAFDTTSFPWSCEYYLEHGRM-------MPEDGIETLRGF 66 Query: 60 RV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 A+ P T P + L + +R+ + Y +RP R G P+K E D++ Sbjct: 67 DAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK-AEGFDILC 125 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E Y+G + E+ V+ F + G +R++R Sbjct: 126 IRENTEGEYSGAGGRVHEGKG--------NEVAVETSVF-----------TRAGVERILR 166 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFT 201 E A + R +T V K N K++ Sbjct: 167 FGFEQARSR-RGHLTSVTKSNAQKYS 191 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 46.2 bits (108), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 29/214 (13%) Query: 3 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD-LIREYRV 61 VDV A LK+ D V Y+ +I + + +K + +V AE D +I Sbjct: 23 VDVLQAALKLYDLKVNLVYE---EIGFASL---KKHKTTFRSEVLKIAEKCDGMILGTCS 76 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 P T GG+ V +R+ DLY +RP + G + P D ++ REN+E Sbjct: 77 HNDYPPTEE--GGLNPSGV-IRKYFDLYANVRPAKNRLGKLE--RFPMGIDCLVMRENTE 131 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 Y+ + K GV ++ I I+ + +G+ R+ +YA Sbjct: 132 GFYSD----------RNMFK------GVGELMPTPDVAISIRNITRKGSTRIAEIGFKYA 175 Query: 182 IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + R + +HK N++++++G F + Q++++ Sbjct: 176 MER-RKKLVAIHKANVLRYSDGLFLECARQVSKK 208 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/127 (28%), Positives = 54/127 (42%), Gaps = 26/127 (20%) Query: 79 NVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEK 138 N + LDLY + +G +H TD+V+ REN+E Y+G+E + E Sbjct: 102 NYKFYKYLDLYSNITFAFSVEGITQ--RHNN-TDIVVIRENTEGEYSGVEHEVYPGVVES 158 Query: 139 VIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 198 IK +++ + R+ A E+A + R VT VHK NIM Sbjct: 159 -----------------------IKVTTKQASLRIAEYAFEFAHLSGRRKVTAVHKANIM 195 Query: 199 KFTEGAF 205 K +G F Sbjct: 196 KLVDGLF 202 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/135 (27%), Positives = 67/135 (49%), Gaps = 14/135 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +K +++ + + + S+ + G K+ + +G +P ET+D + Sbjct: 13 IGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MPKETIDSCLKSD 67 Query: 61 VAIKGPLTTP----VGGGIRSLN--VALRQELDLYICLRPVRYYQG-TPSPVKHPEL--T 111 + G + P G+R + + LR+E+DLY +RP+ Y G SP+K +L Sbjct: 68 AVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSPIKERKLEGV 127 Query: 112 DMVIFRENSEDIYAG 126 + VI+RE + IY G Sbjct: 128 NFVIYRELTGGIYFG 142 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/94 (27%), Positives = 51/94 (54%), Gaps = 3/94 (3%) Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 ++++FR + G+E++++S + ++K E+G ++I PE +GI+ + + Sbjct: 102 NVLLFRYELDMSDTGMEFESNSGEQLALVKTA-AELGPREI--PEQAALGIQAIAPDRVS 158 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 VR A+ D D + + HKGN +K T+G F Sbjct: 159 EFVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLF 192 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/133 (30%), Positives = 61/133 (45%), Gaps = 15/133 (11%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEI-YTGEKSTQVYGQDVWLPAETLDLIREY 59 IGVDVT +KV+D+A +I W E Y+ E+ + +P + + + Sbjct: 15 IGVDVTREAVKVMDSATGG------RIEWTEFDYSCERYAKT---GAMMPPDAPTTLAGF 65 Query: 60 RVAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK--HPELTDMV 114 + G + P + L + LR+ + Y+ LRPVR G SP+ E MV Sbjct: 66 DAILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLAGVSDEALSMV 125 Query: 115 IFRENSEDIYAGI 127 I REN+E Y+ I Sbjct: 126 IVRENTEGEYSPI 138 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 45.4 bits (106), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 24/121 (19%) Query: 82 LRQELDLYICLRPVRYYQGTPSPVK--HPELTDMVIFRENSEDIYAGIEWKADSADAEKV 139 LR+ L LY +RP+R Y +P+K P D V+ RE++E ++ G + AD +A++ Sbjct: 96 LRERLQLYGGVRPIRLYHEADTPLKGHGPGEIDFVLVRESTEGLFYGRDAIAD-LEADEA 154 Query: 140 IKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAND-RDSVTLVHKGNIM 198 LR + ++R+ R A E A D + +VTL+ K N++ Sbjct: 155 TNLLR--------------------ITRSASERVCRLAFETARRRDGKKTVTLIDKANVL 194 Query: 199 K 199 Sbjct: 195 S 195 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 45.1 bits (105), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/132 (29%), Positives = 59/132 (44%), Gaps = 13/132 (9%) Query: 80 VALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKV 139 + LRQ LDLY +RPV G V+ REN+E +YAG+++ DA Sbjct: 103 IQLRQNLDLYANVRPVTDMTGE-------NRFRFVVIRENTEGLYAGLDFGC-IPDALVP 154 Query: 140 IKFLREEMGVKKIR-FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIM 198 + RE +G R + + ++ + G R+ A EYA N VT V K ++ Sbjct: 155 LLEEREALGAAWQREGQDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVL 214 Query: 199 K----FTEGAFK 206 + F G F+ Sbjct: 215 RHSSAFARGIFE 226 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 44.3 bits (103), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/73 (39%), Positives = 39/73 (53%), Gaps = 10/73 (13%) Query: 65 GPLTTPVGGGIRSLNVAL---RQELDLYICLRPVRYY-------QGTPSPVKHPELTDMV 114 GP +G G + + A+ R +LDLY +RPV+ GT V PE DMV Sbjct: 89 GPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGVAHRISGTRQQVWRPEHVDMV 148 Query: 115 IFRENSEDIYAGI 127 I REN+E +YAG+ Sbjct: 149 ILRENTEGLYAGM 161 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 43.5 bits (101), Expect = 0.006, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 85/225 (37%), Gaps = 38/225 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++VT A L V + I W E + E + +P+ T LI Sbjct: 17 IGIEVTEATLPVFEVLDVPVILNYGDIGW-EFWKKEGAA--------IPSRTWQLIASSD 67 Query: 61 VAIKGPLTTP--------VGGGIRSLN-------VALRQELDLYICLRPVRYYQGTPSPV 105 + G +T+ + ++ N + LRQ LDL+ +RP P Sbjct: 68 TVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDDQSKPF 127 Query: 106 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 + I RENSE +Y G ++ K I L E + + ++ Sbjct: 128 ------NFCIIRENSEGLYCGFDY----FPLPKAIHSLLAESQHWQTIPADEASCALRLQ 177 Query: 166 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMK----FTEGAFK 206 S+ G RL A ++A+ VTL K N+++ FT F+ Sbjct: 178 SKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFE 222 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 42.7 bits (99), Expect = 0.010, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 84/200 (42%), Gaps = 27/200 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ +K Y + M ++ E Q +G+ +P LD+++ Y Sbjct: 14 IGPEVMNEALKVLRILKDKDYTFQFHAD-MFLWNSEYYLQ-HGR--MMPENGLDILKNYD 69 Query: 61 VAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-TDMVIF 116 + G + P + L + +R+ Y+ LRPV+ +G P H E + VI Sbjct: 70 AILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQERPINFVIV 129 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y S ++ + +E+ V+ + +GT+R+ R Sbjct: 130 RENAEGEY--------SNSGGRIYQGTDQEIAVQN-----------TIITRKGTERIARY 170 Query: 177 AIEYAIANDRDSVTLVHKGN 196 A +YA + V K N Sbjct: 171 AFQYAKKHGYQKVINATKSN 190 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 41.6 bits (96), Expect = 0.018, Method: Compositional matrix adjust. Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 2/45 (4%) Query: 82 LRQELDLYICLRPVRYYQGTPSPVKHPEL--TDMVIFRENSEDIY 124 LR+ LDL+ C RP G P P+ P TD+++ RENSE Y Sbjct: 103 LRKGLDLWACERPAVPLAGAPMPLSDPRALHTDLLVIRENSEGEY 147 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 41.6 bits (96), Expect = 0.020, Method: Compositional matrix adjust. Identities = 48/209 (22%), Positives = 89/209 (42%), Gaps = 33/209 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGE-KSTQVYGQD-VWLPAETLDLIRE 58 IG++V P ++V++AA K +E T E S Y Q +P + + +++ Sbjct: 16 IGLEVLPEGIRVLEAAALKHGLA------LEFDTFEWASCDYYLQHGKMMPDDWAEQLKQ 69 Query: 59 YRV----AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL--TD 112 Y A+ P P + + R+E D Y+ +RPVR + G P + + ++ D Sbjct: 70 YDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRKVGDID 129 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 V+ REN+E Y+ + + + E+ +++ F + G R Sbjct: 130 FVVVRENTEGEYSSL--------GGIMFENTENEIVIQESIF-----------TRRGVDR 170 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFT 201 +++ A + A +R VT K N M + Sbjct: 171 ILKYAFDLAEKRERKHVTSATKSNGMAIS 199 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 40.4 bits (93), Expect = 0.043, Method: Compositional matrix adjust. Identities = 28/86 (32%), Positives = 45/86 (52%), Gaps = 8/86 (9%) Query: 52 TLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 111 +D+++ R A G L +GGGIR ++ +DLY+ L R G+ + +K+P+LT Sbjct: 61 NVDIVKAVRAAFTGIL--EIGGGIRD-----KEAVDLYLSLGVDRVILGSVA-LKNPKLT 112 Query: 112 DMVIFRENSEDIYAGIEWKADSADAE 137 VI +E I G++ K AE Sbjct: 113 KQVIAEYGAEHIVIGVDGKNGKVAAE 138 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 309 6e-83 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 299 4e-80 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 292 5e-78 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 280 2e-74 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 276 3e-73 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 276 3e-73 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 267 2e-70 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 267 2e-70 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 266 4e-70 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 262 6e-69 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 260 3e-68 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 256 3e-67 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 254 1e-66 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 243 4e-63 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 241 2e-62 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 236 4e-61 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 217 3e-55 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 215 9e-55 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 213 3e-54 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 211 2e-53 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 208 9e-53 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 205 8e-52 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 204 2e-51 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 204 2e-51 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 199 5e-50 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 197 2e-49 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 196 6e-49 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 195 6e-49 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 195 8e-49 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 194 2e-48 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 194 2e-48 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 193 3e-48 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 190 2e-47 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 189 7e-47 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 188 9e-47 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 188 1e-46 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 187 3e-46 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 186 4e-46 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 184 2e-45 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 181 1e-44 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 179 5e-44 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 179 6e-44 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 178 1e-43 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 177 2e-43 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 177 2e-43 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 176 4e-43 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 176 4e-43 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 175 6e-43 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 175 1e-42 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 174 1e-42 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 173 3e-42 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 173 4e-42 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 173 4e-42 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 172 8e-42 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 172 1e-41 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 171 1e-41 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 171 2e-41 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 171 2e-41 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 170 3e-41 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 170 3e-41 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 170 3e-41 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 170 3e-41 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 169 8e-41 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 167 3e-40 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 167 3e-40 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 165 7e-40 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 165 8e-40 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 165 1e-39 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 164 2e-39 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 164 2e-39 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 164 3e-39 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 164 3e-39 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 163 3e-39 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 163 5e-39 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 160 4e-38 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 159 8e-38 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 157 2e-37 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 156 4e-37 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 156 4e-37 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 156 4e-37 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 156 6e-37 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 155 1e-36 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 155 1e-36 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 154 2e-36 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 153 4e-36 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 153 5e-36 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 152 9e-36 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 152 1e-35 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 152 1e-35 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 150 3e-35 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 148 2e-34 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 147 3e-34 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 147 3e-34 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 146 5e-34 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 146 6e-34 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 145 9e-34 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 145 9e-34 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 145 1e-33 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 145 1e-33 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 144 2e-33 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 143 3e-33 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 142 6e-33 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 141 1e-32 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 141 2e-32 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 140 3e-32 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 140 3e-32 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 139 6e-32 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 136 5e-31 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 136 5e-31 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 135 1e-30 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 133 3e-30 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 133 5e-30 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 133 5e-30 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 128 9e-29 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 122 9e-27 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 112 1e-23 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 79 1e-13 Sequences not found previously or not previously below threshold: UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 147 2e-34 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 147 4e-34 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 146 6e-34 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 145 1e-33 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 134 2e-30 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 129 7e-29 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 127 2e-28 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 123 3e-27 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 123 4e-27 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 121 2e-26 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 117 3e-25 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 117 4e-25 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 116 6e-25 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 116 7e-25 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 115 8e-25 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 113 4e-24 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 113 5e-24 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 113 6e-24 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 110 3e-23 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 109 7e-23 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 108 1e-22 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 107 3e-22 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 104 2e-21 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 101 2e-20 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 101 2e-20 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 99 8e-20 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 97 3e-19 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 96 7e-19 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 96 7e-19 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 96 9e-19 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 95 1e-18 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 94 4e-18 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 92 1e-17 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 91 2e-17 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 91 3e-17 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 88 2e-16 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 87 4e-16 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 86 7e-16 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 86 8e-16 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 86 9e-16 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 85 2e-15 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 84 3e-15 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 84 5e-15 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 80 5e-14 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 80 6e-14 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 79 1e-13 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 76 9e-13 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 73 5e-12 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 72 1e-11 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 70 4e-11 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 70 6e-11 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 68 3e-10 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 65 2e-09 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 65 3e-09 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 62 1e-08 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 61 4e-08 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 57 4e-07 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 55 1e-06 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 54 3e-06 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 54 4e-06 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 53 9e-06 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 52 1e-05 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 52 2e-05 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 50 7e-05 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 49 1e-04 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 48 3e-04 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 47 3e-04 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 47 6e-04 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 45 0.001 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 44 0.003 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 44 0.004 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 42 0.014 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 309 bits (791), Expect = 6e-83, Method: Composition-based stats. Identities = 175/222 (78%), Positives = 200/222 (90%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVD++P M+KVVDAAVEKAYKGERKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y Sbjct: 39 IGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYV 98 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGGIRSLNVALRQ+LDLY+C RPVR+++G PSPVK P DMVIFRENS Sbjct: 99 VSIKGPLTTPVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENS 158 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAG+EWKA S +AEKVIKFL EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++Y Sbjct: 159 EDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQY 218 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A+ NDR SVTLVHKGNIMKFTEGAFKDWGY++AR+EFG EL+ Sbjct: 219 AVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELL 260 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 299 bits (766), Expect = 4e-80, Method: Composition-based stats. Identities = 157/222 (70%), Positives = 189/222 (85%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVTP MLKVV+AAV KAY G+RKI W+E+Y GEK+T++Y + WLP ETL++++EY+ Sbjct: 37 IGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYK 96 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGG+ SLNVA+RQ LDLY+C RPV+++ G PSPVK P DMVIFREN+ Sbjct: 97 VSIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENT 156 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE+KA S A+ VIKFL EEMG IRF E+CGIGIKP S+EG++RLVR AI+Y Sbjct: 157 EDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQY 216 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N++DSVTLVHKGNIMKFTEGAFKDWGY+LA EEFG L+ Sbjct: 217 AIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLL 258 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 292 bits (748), Expect = 5e-78, Method: Composition-based stats. Identities = 147/222 (66%), Positives = 178/222 (80%), Gaps = 2/222 (0%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG D+ A +V+DAAVEKAY GE++I W E+ G+K+ G+ WLP ETLD I+EY Sbjct: 29 IGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGE--WLPQETLDTIKEYL 86 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLRPVR+++G PSPVK P+ DMVIFREN+ Sbjct: 87 IAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENT 146 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE+K + + +KVI FL+ EMG IRFPE GIGIKP S+EGT+RLVRAAI+Y Sbjct: 147 EDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQY 206 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N+R SVTLVHKGNIMKFTEG+FK WGY LA EFG ++ Sbjct: 207 AIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVF 248 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 280 bits (716), Expect = 2e-74, Method: Composition-based stats. Identities = 126/228 (55%), Positives = 167/228 (73%), Gaps = 7/228 (3%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G+D+ PA KV+DAAV KAY G+RKISW ++Y G+++ +YG +LP +TL I+EY + Sbjct: 38 GIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGI 97 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 AIKGPLTTP+GGGIRSLNVALRQ DLY C+RP RYY GTPSP K P+ D++++REN+E Sbjct: 98 AIKGPLTTPIGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTE 157 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVK-----KIRFPEHCGIGIKPCSEEGTKRLVRA 176 DIY GIEWK S E++I L +++ K + P GIGIKP S G++RLVR Sbjct: 158 DIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIPLDAGIGIKPISRSGSQRLVRR 217 Query: 177 AIEYAIANDRDS--VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A+++A+ ++ VTLVHKGNIMK+TEGAF+DWGY+LA +EF E + Sbjct: 218 ALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELATQEFRAECV 265 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 276 bits (707), Expect = 3e-73, Method: Composition-based stats. Identities = 131/217 (60%), Positives = 161/217 (74%), Gaps = 3/217 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DV PA KV++AA E R ISWM +Y GE + + YG+DV LP ET+D IRE+R Sbjct: 41 IGKDVGPAAQKVLEAAAE---ATGRDISWMRVYAGESAREEYGEDVNLPDETVDAIREHR 97 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGPLTTPVG G RSLNVALRQ LDLY +RP Y G PSP+K PE DMV FREN+ Sbjct: 98 VAIKGPLTTPVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENT 157 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW+A + + E+V +F+ +EMG + GIG+KP +E+G+KRLVR AI+Y Sbjct: 158 EDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A+ +DRD VTLVHKGNIMKFTEG F DWG ++A EE+ Sbjct: 218 ALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEY 254 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 276 bits (706), Expect = 3e-73, Method: Composition-based stats. Identities = 147/229 (64%), Positives = 186/229 (81%), Gaps = 8/229 (3%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVY-------GQDVWLPAETL 53 IG D+TPAM+KVVD+AV+KAYKGE+KI+W E++ GEK Q + ++ WL +T+ Sbjct: 40 IGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTI 99 Query: 54 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 + I Y+V+IKGPLTTP+G G RSLNVALRQ++DLY+CLRPVR+Y G+PSPVK P+ DM Sbjct: 100 EAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDM 158 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 VIFRENSEDIYAGIEW+ SA+A+K+I FL+ E+ V+KIRFPE G+GIKP S+EGT+RL Sbjct: 159 VIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPISKEGTERL 218 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 VR AIEYAI ND+ SVT VHKGNIMK+TEGAF WGY LA++EF ++I Sbjct: 219 VRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQVI 267 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 267 bits (682), Expect = 2e-70, Method: Composition-based stats. Identities = 120/222 (54%), Positives = 160/222 (72%), Gaps = 3/222 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A V DAAV+KAY G+++++W+ + GE + + GQ WLP +TL +REY Sbjct: 29 IGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQ--WLPDKTLATLREYL 86 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV YY GTPSPV HPE ++ +FREN+ Sbjct: 87 VGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPVVHPENVNIDVFRENT 146 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE D+ DAE+ L ++ + K+RFP+ IKP S++G+ RLV AAI+Y Sbjct: 147 EDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIKPISKQGSTRLVDAAIDY 206 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A AN+R ++TLVHKGNIMK TEG FK WGY+ A E++G ++ Sbjct: 207 AFANNRHTLTLVHKGNIMKKTEGGFKKWGYE-AAEKYGDKVF 247 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 267 bits (682), Expect = 2e-70, Method: Composition-based stats. Identities = 120/219 (54%), Positives = 173/219 (78%), Gaps = 1/219 (0%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G DV P M KVVD+A+ Y+ +RKI WM++Y GE++ ++Y D W P ET++ +RE + Sbjct: 42 VGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGD-WFPQETINAVRECK 100 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +AIKGPLTTP+GGG RSLNVALRQE+DL++ +R ++ + PSP+K+P LT++ + R++S Sbjct: 101 IAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSS 160 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y+GIEW+A S ++EKV+ FL EEMGV ++RF + CGIGIK S+EG++RLVR AI Y Sbjct: 161 EDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINY 220 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A+ N+ +S+TLVHKGN++KFT+GAFK WG+ LA+ E+ Sbjct: 221 ALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQA 259 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 266 bits (680), Expect = 4e-70, Method: Composition-based stats. Identities = 123/228 (53%), Positives = 160/228 (70%), Gaps = 7/228 (3%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 GVD+ PA V++AA+ KAY G +I+W ++Y G+++ ++YG P +TL I+EY V Sbjct: 38 GVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGV 97 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 AIKGPLTTPVGGGIRSLNVALRQ DLY C+RP RYY GTPSP K PE D++++REN+E Sbjct: 98 AIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTE 157 Query: 122 DIYAGIEWKADSADAEKVIKFLREEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 DIY GIEW + A+K+I +L +E+ + K + GIGIKP S+ G++RLVR Sbjct: 158 DIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRLDSGIGIKPISKTGSQRLVRR 217 Query: 177 AIEYAIANDRDS--VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI +A + VTLVHKGNIMKFTEG F+DWGY+LA EF E + Sbjct: 218 AILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELATTEFRAECV 265 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 262 bits (670), Expect = 6e-69, Method: Composition-based stats. Identities = 115/222 (51%), Positives = 161/222 (72%), Gaps = 5/222 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A +KV + AVEKAY R+I+W EI GEK+ +++G LP ++++++R+ R Sbjct: 55 IGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNR--LPDQSIEVLRKIR 112 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K PL TPVGGG RS+NV LRQ DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ Sbjct: 113 VFLKAPLETPVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENT 172 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW +S +A K+ +FLR E GV + GIGIKP S+ GT+R+ R A+++ Sbjct: 173 EDVYAGIEWPYNSPEAAKIREFLRREFGV---NIRDDAGIGIKPISKFGTQRIARLALKF 229 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N R VT++HKGNI K+TEGAFK+W +++AR EF ++ Sbjct: 230 AIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVV 271 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 260 bits (664), Expect = 3e-68, Method: Composition-based stats. Identities = 116/222 (52%), Positives = 149/222 (67%), Gaps = 6/222 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + KV+DAAV+KAY G R+I W E+ GE++ + G LP TL + R Sbjct: 43 IGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGS--LLPDGTLQAFKLAR 100 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPLTTPVGGG RSLNV LR LDLY +RPV++Y G P+P HPE D VIFREN+ Sbjct: 101 VNLKGPLTTPVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENT 159 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW DS +A+K+ FL++E G I GIGIKP S+ T+R VR A+E+ Sbjct: 160 EDVYAGIEWPFDSPEAQKIRDFLKKEFG---IELTPDTGIGIKPISKWRTQRHVRRAMEW 216 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N VT++HKGNIMK+TEGAF+ W Y L EF ++ Sbjct: 217 AIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVV 258 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 256 bits (655), Expect = 3e-67, Method: Composition-based stats. Identities = 123/217 (56%), Positives = 156/217 (71%), Gaps = 5/217 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DV PA KV++AA A R+ISWM ++ GE + + Y ++ LP +T++ I E+R Sbjct: 43 IGKDVGPAAQKVLEAA---ANATGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHR 97 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGPLTTPVG G RSLNVALRQ LD Y +RP Y G PSP+K PE DMV FREN+ Sbjct: 98 VAIKGPLTTPVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENT 157 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW+A + + E+V +F+ E+MG + GIGIKP +E G+KRLVR AI+Y Sbjct: 158 EDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 AI +DRD VTLV KGNIMKFTEG F +WG ++A EE+ Sbjct: 218 AIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEY 254 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 254 bits (650), Expect = 1e-66, Method: Composition-based stats. Identities = 93/216 (43%), Positives = 128/216 (59%), Gaps = 15/216 (6%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT AM V++A+ + W+ + G + + YG LP + L+ IRE R Sbjct: 13 IGPEVTRAMTTVLEAS-------GVDLEWIRVEAGVEVIEKYGTP--LPPQVLESIRETR 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + D+V+ REN+ Sbjct: 64 VAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF---QDIDLVVVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE++ + +A + + G E IGIKP SE G++R+V+ A EY Sbjct: 121 EDLYAGIEFERGTPEAAHAREEMMRLSGKF---IREGSAIGIKPISEFGSRRIVKFAFEY 177 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A N R VT VHK NIMKFT+G F ++A+E Sbjct: 178 ARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEY 213 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 243 bits (620), Expect = 4e-63, Method: Composition-based stats. Identities = 110/223 (49%), Positives = 161/223 (72%), Gaps = 4/223 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T AML +++ AVEK Y G +KI W+E+ G+K+ + G+ LP ETLD+++E Sbjct: 49 IGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGER--LPQETLDVLKESI 106 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGPL TPVG G+RS+N ALR+ D Y +RPV Y+ G +P+ +PE D+V+FREN+ Sbjct: 107 VGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENT 165 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 +D+YAG+E+ A + +A+KV +FL +EMG K+ FPE GI +KP SE TKR VR A+ Y Sbjct: 166 DDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRY 225 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE-EFGGELI 222 A+ N++ +V ++ KGNIMK TEGAF +W +++A E EF G+++ Sbjct: 226 ALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVV 268 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 241 bits (614), Expect = 2e-62, Method: Composition-based stats. Identities = 89/225 (39%), Positives = 128/225 (56%), Gaps = 18/225 (8%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A +V++A W G + G LP L+ IR +V Sbjct: 14 GPELAEATRRVLEA-------TGVAFDWDIQDAGVDVMEQLGTP--LPDSVLESIRSTKV 64 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S E D+V+ REN+E Sbjct: 65 ALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRS---RFENIDLVVVRENTE 121 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 D+YAGIE++ + + ++ +L ++ I+ P GI IKP S G++R+VR A EYA Sbjct: 122 DLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPG--GISIKPMSVPGSERIVRFAFEYA 179 Query: 182 IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELI 222 AN R VT VHK NIMKF++G F + ++A+E EF ++ Sbjct: 180 RANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIV 224 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 236 bits (603), Expect = 4e-61, Method: Composition-based stats. Identities = 135/183 (73%), Positives = 157/183 (85%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG+D++P M+KVVDAAV+KAY GERKISWME+Y GEK+TQVY QD WLP ETLD +++Y Sbjct: 39 IGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYV 98 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGGIRSLNVALRQ+LDLY+CLRPVR+++G PSPVK P DM IFRENS Sbjct: 99 VSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENS 158 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIEWKA S +A KVIKFL+EEMGV KIRF + CGIG+KP S+EGTKRL R A+ Sbjct: 159 EDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHS 218 Query: 181 AIA 183 A A Sbjct: 219 AEA 221 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 217 bits (552), Expect = 3e-55, Method: Composition-based stats. Identities = 73/216 (33%), Positives = 105/216 (48%), Gaps = 33/216 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A++ ++ AA ++E+ GE+ G +P E D I R Sbjct: 32 IGPEITAAVMSILSAA-----GAHLDAEYVEV--GEQVYLR-GNTSGIPQEAWDSIARTR 83 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ P D+VI REN Sbjct: 84 VMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK--PIVTTRHPDMDVVIVRENE 141 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE R + +K + G++R+ R A EY Sbjct: 142 EDLYAGIEH-----------------------RQTQDVAQCLKLITRSGSERIARYAFEY 178 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + R +T + K NIMK T+G F ++ARE Sbjct: 179 ARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREY 214 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 215 bits (547), Expect = 9e-55, Method: Composition-based stats. Identities = 62/216 (28%), Positives = 103/216 (47%), Gaps = 35/216 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT A ++V++A K W G ++ + Y + ++P E + I R Sbjct: 13 IGPEVTSAAVRVLEA-------TGLKFEWESFAAGAEAYEKYKE--YIPKELNESIERTR 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + D+V+ REN+ Sbjct: 64 IGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRYPG---VDLVVVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+GIE + E +K +E+ + R+ + A Y Sbjct: 121 EGLYSGIEHEVVPGVVE-----------------------SLKIITEKASTRISKFAFNY 157 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A R + +HK NIMK ++G F +++E Sbjct: 158 ARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEY 193 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 213 bits (543), Expect = 3e-54, Method: Composition-based stats. Identities = 67/216 (31%), Positives = 107/216 (49%), Gaps = 35/216 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A+ ++ A + I W + + T+ +P +LD+IR++ Sbjct: 1987 IGPEISAAVQEIFKFA-------DVPIKWESVDVTPRPTE--DGRFRMPQSSLDIIRKHG 2037 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGPL TP+G G +SLN+ALR+E +LY +RP + +G +P K+ D+V REN+ Sbjct: 2038 IGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYKN---VDLVTVRENT 2094 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK +EE ++R+ R A +Y Sbjct: 2095 EGEYSGIEHVIVDGVVQ-----------------------SIKLITEEASRRVARFAFQY 2131 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A N R SVT VHK NIM+ ++G F + A Sbjct: 2132 AKDNGRRSVTAVHKANIMRMSDGLFLRVCREEAAHH 2167 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 211 bits (536), Expect = 2e-53, Method: Composition-based stats. Identities = 63/214 (29%), Positives = 99/214 (46%), Gaps = 35/214 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A++K+ DAA I W E + Q G +P+E + + + + Sbjct: 42 IGPEISAAVMKIFDAAKA-------PIQWEERNV--TAIQGPGGKWMIPSEAKESMDKNK 92 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGPL TP+ G S+N+ LR+ DLY +RP +G +P ++V REN+ Sbjct: 93 MGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DVNIVTIRENT 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK +E +KR+ A EY Sbjct: 150 EGEYSGIEHVIVDGVVQ-----------------------SIKLITEGASKRIAEFAFEY 186 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 A N R +VT VHK NIM+ ++G F ++A Sbjct: 187 ARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAE 220 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 208 bits (530), Expect = 9e-53, Method: Composition-based stats. Identities = 70/218 (32%), Positives = 99/218 (45%), Gaps = 31/218 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ +++ V+DA W Y G + G LP ET+ I + Sbjct: 23 IGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGDP--LPRETIQSIHHNK 73 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+KGPLTTP GGG RS+NV LR+E +L+ +RP P E D+ + REN Sbjct: 74 LALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTL----IPGGRFENVDITLIRENL 129 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + YA E D P + + G R++R A EY Sbjct: 130 DGFYAAFEHYMPIGD------------------DPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 A+ N R VTLVHK NI+K G F + G ++A+E G Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEG 209 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 205 bits (522), Expect = 8e-52, Method: Composition-based stats. Identities = 66/218 (30%), Positives = 102/218 (46%), Gaps = 40/218 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG VT A+ +V++A M + +V G +P E ++ ++ + Sbjct: 49 IGPLVTGAVEQVMEA--------------MHAPVHFERYEVLGNMRKVPEEVIESVKRNK 94 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KG L TPVGGG+ SLN+ LR+ELD++ L G V E D+V+ REN+ Sbjct: 95 VCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGL---VTRHENVDIVVIRENT 151 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+G+E + E +K ++ ++R+ R A EY Sbjct: 152 EGEYSGLEHEVVPGVVE-----------------------SLKVITKFCSERIARYAFEY 188 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 A N+R VT VHK NIMK +G F + ++A+ G Sbjct: 189 AYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSG 226 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 204 bits (518), Expect = 2e-51, Method: Composition-based stats. Identities = 56/216 (25%), Positives = 98/216 (45%), Gaps = 41/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ +V A I W + V + + E ++ I + + Sbjct: 34 IGPEISESVKRVFSAVKA-------PIEWETV--------VVDANTGISKEVIESISKNK 78 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGP++TP+G G +SLN+ LR+ +LY +RP G + + V+ REN+ Sbjct: 79 IGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCLSIPGHKTRY---NNVNTVVVRENT 135 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + A+ IK ++E + R+ A +Y Sbjct: 136 EGEYSGIENQPVKGVAQ-----------------------SIKIITKEASTRIAHYAFQY 172 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A+AN R VT +HK NIMK ++G F +++ Sbjct: 173 ALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRY 208 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 204 bits (518), Expect = 2e-51, Method: Composition-based stats. Identities = 62/226 (27%), Positives = 107/226 (47%), Gaps = 40/226 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ + AA I W + + + +P + ++ +R Sbjct: 65 IGPEISQSVKDIFSAANA-------PIKWEPVDV---TPILKDGKTAIPDDAIESVRRNY 114 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G +P + D V+ REN+ Sbjct: 115 VALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---DNVDTVLIRENT 171 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK ++E ++R++R A +Y Sbjct: 172 EGEYSGIEHVVVDGVVQ-----------------------SIKLITKEASERVLRFAFQY 208 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELI 222 A + ++ V +VHK IMK ++G F + ++A++ EF EL+ Sbjct: 209 ARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELL 254 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 199 bits (506), Expect = 5e-50, Method: Composition-based stats. Identities = 58/216 (26%), Positives = 95/216 (43%), Gaps = 35/216 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A+ + AA + I W K G + E+L+ + Y+ Sbjct: 315 IGPEISQAVCDIFAAA-------KVPIDWEHHEIYTKPINEAGD--LIKEESLNAVINYK 365 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +KGP TP+G G RSLNV +R++L+L+ +RP R G +P + D+V REN+ Sbjct: 366 WGLKGPFATPIGKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYSN---VDLVTIRENT 422 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+G+E E + K S+ + + R A E+ Sbjct: 423 EGEYSGLEHAVVPGVVENL-----------------------KIISQPACENIARYAFEF 459 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A N+R V HK +MK +G F + +++ E Sbjct: 460 ARKNNRKKVVACHKAGVMKKGDGLFINTCKKISSEY 495 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 197 bits (501), Expect = 2e-49, Method: Composition-based stats. Identities = 66/216 (30%), Positives = 101/216 (46%), Gaps = 32/216 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + ++++A I W G S G +P +T++ I+ R Sbjct: 31 IGPEIVESACRLIEAVGA-------PIEWEVRRAG-ASVFREGIASGVPDDTIESIKRTR 82 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPL TPVG G +S NV LR+ + + +RPVR P+P + D+V+ REN Sbjct: 83 VVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRGRN-IDLVVVRENI 141 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YA IE++ I K S +G+++++R A E Sbjct: 142 EDLYAAIEYRETPG-----------------------VTIAHKLISYKGSEKIIRFAFEL 178 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A A R VT K NI+K TEG F+ ++A E Sbjct: 179 ARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEY 214 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 196 bits (498), Expect = 6e-49, Method: Composition-based stats. Identities = 70/217 (32%), Positives = 111/217 (51%), Gaps = 33/217 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G DV A L V+DA +K I ++ G + + YG + LP ETLD ++E Sbjct: 16 VGPDVINASLLVLDAVKKKFN---LDIEYVPAVAGLNTVEKYGTN--LPKETLDTLKETD 70 Query: 61 VAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +KGP TTP G + S NV +R+ DLY +RP + PS DMVI REN Sbjct: 71 CVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI---KPNVDMVIVREN 127 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E +Y+G++++ + + IGI+ + + +R+V+ A + Sbjct: 128 TEGMYSGLDFRVN-----------------------QETTIGIRVITRKACERIVKYAFK 164 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + + VTLVHKGN++K ++G FKD Y+ A++ Sbjct: 165 LAESR-KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKH 200 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 195 bits (497), Expect = 6e-49, Method: Composition-based stats. Identities = 73/216 (33%), Positives = 99/216 (45%), Gaps = 32/216 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + A LKV++AA E+ S G +P ET++ IR+ R Sbjct: 30 IGPECVEATLKVLEAAKAPLA--------YEVREAGASVFRRGIASGVPQETIESIRKTR 81 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPL TPVG G +S NV LR+ + Y +RPVR + P+P D+V+ REN Sbjct: 82 VVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGRG-IDLVVVRENV 140 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE +K S +G++++VR A E Sbjct: 141 EDLYAGIEH-----------------------MQTPSVAQTLKLISWKGSEKIVRFAFEL 177 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A A R V K NIMK EG K Q+A+E Sbjct: 178 ARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEY 213 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 195 bits (496), Expect = 8e-49, Method: Composition-based stats. Identities = 75/217 (34%), Positives = 107/217 (49%), Gaps = 12/217 (5%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A V+D A + KI W G+++ + LP TL+ IR Sbjct: 15 GPELVDAARSVLDHAARLS---GFKIDWDVHQAGQRALAE--SESLLPDATLNSIRTNGA 69 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL--TDMVIFREN 119 A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR S + PE D+V+ REN Sbjct: 70 ALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEEPERPHVDLVVVREN 128 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +ED+YAG+E+ S A V++ L G P + +KP + G +R+V A Sbjct: 129 TEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTPHGCERVVEFAFN 184 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 +A + R V V TEG F ++A Sbjct: 185 HAARHGRKLVESVCDARRYPATEGMFARVASKVAARH 221 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 63/216 (29%), Positives = 98/216 (45%), Gaps = 33/216 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A LKV+ + ++ +I G K + G + + + ++ + Sbjct: 14 IGPEIMDATLKVI-------LEAGAELEIEKIEIGFKVYSM-GNPSGIEPSSWESLKRTK 65 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K P+TTP GGG +SLNV +R+ L LY +RP Y P D+VI REN Sbjct: 66 VFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISYA--PFIHTKHPGIDLVIIRENE 123 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y GIE + +K + +GT+R++R A EY Sbjct: 124 EDLYGGIEHRQGV-----------------------DSFQALKIMTRQGTERIIRYAFEY 160 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A R V+ K NI+K T+G F ++A+E Sbjct: 161 ARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEY 196 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 194 bits (493), Expect = 2e-48, Method: Composition-based stats. Identities = 59/216 (27%), Positives = 95/216 (43%), Gaps = 36/216 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ K+ AA I W +P + I + Sbjct: 47 IGPEISKSVKKIFSAA-------NVPIEWESCDVSPIFVN---GLTTIPDPAVQSITKNL 96 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VA+KGPL TP+G G RSLN+ LR+ L+ +RP + +G + E D+V+ REN+ Sbjct: 97 VALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---ENVDLVLIRENT 153 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK + + ++R++R A EY Sbjct: 154 EGEYSGIEHIVCPGVVQ-----------------------SIKLITRDASERVIRYAFEY 190 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A A R V +VHK I + +G F + +L++E Sbjct: 191 ARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEY 226 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 193 bits (491), Expect = 3e-48, Method: Composition-based stats. Identities = 68/223 (30%), Positives = 105/223 (47%), Gaps = 37/223 (16%) Query: 1 IGVDVTPAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREY 59 IG ++ A++ V+ +AAV + I GEK Y + +T I Sbjct: 15 IGPEIMEAVVYVLKEAAV--------PLRLETIEIGEKLYNKY-YTYGITEDTWSQIFRT 65 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELTDMVIFRE 118 + +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + D+VI RE Sbjct: 66 KALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNT---SAPEIDVVIIRE 122 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N ED+YAGIE+ +K S G+++++R A Sbjct: 123 NEEDLYAGIEYHH-----------------------TADTYESVKLISRSGSEKIIRFAF 159 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 EYA+ N+R +++ K NIMKFT+G F ++A + ++ Sbjct: 160 EYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQV 202 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 190 bits (484), Expect = 2e-47, Method: Composition-based stats. Identities = 63/216 (29%), Positives = 104/216 (48%), Gaps = 36/216 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ ++L+++ ++ +I I G+K + G + + ++ + Sbjct: 12 VGPEIMTSVLEII-------FEAGAEIQIDTIEIGQKIYEK-GWPSGISDSGWETLKRNK 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P D+VI REN Sbjct: 64 VLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDP-----KMDIVIIRENE 118 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y+GIE+ R K +E ++R+ R A EY Sbjct: 119 EDLYSGIEY-----------------------RQTLDTYNCTKVITESTSERICRYAFEY 155 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A +N R VT++ K NIMK T+G F ++A E Sbjct: 156 ARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEY 191 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 189 bits (480), Expect = 7e-47, Method: Composition-based stats. Identities = 75/217 (34%), Positives = 115/217 (52%), Gaps = 17/217 (7%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A V+D A A + W G+ + + G+ LPA TLD IR V Sbjct: 15 GPELVAAARTVLDTA---AGSAGFHLDWDVRPAGQGALRSVGE--LLPASTLDSIRRNGV 69 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + D+V+ REN+E Sbjct: 70 ALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAVDSG---IDVVVVRENTE 126 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 D+Y+G+E+ ADS D V+ E G +KP + G++R+V A+++A Sbjct: 127 DVYSGLEYPADS-DGAAVVSATLSEFGHAD----PGIAFSLKPITPGGSRRIVAFALDHA 181 Query: 182 IANDRDSVTLVHKGNIMKF--TEGAFKDWGYQLAREE 216 N R V + ++ ++ TEG F + +L E Sbjct: 182 RKNGRRKVEV--GADVYRYPRTEGLFFEAARELGPEY 216 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 188 bits (478), Expect = 9e-47, Method: Composition-based stats. Identities = 53/216 (24%), Positives = 91/216 (42%), Gaps = 40/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + +++ K + + G+++ + YG+ LP ETL+ R+ Sbjct: 12 IGKEVMEAAMLILE-------KLDLPFEYSYYDAGDEALEKYGK--ALPDETLEACRKSD 62 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V LR+EL + +RP + +G D+V+ REN+ Sbjct: 63 AVLFGA----AGETAADVIVRLRRELGTFANVRPAKAIEGIECLYPG---LDIVVVRENT 115 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y G E+ I+ + E ++R+ R A E Sbjct: 116 ECLYMGFEFGFG------------------------DVTEAIRVITREASERIARYAFEL 151 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A R VT +HK N+MK T G F+D ++A++ Sbjct: 152 AKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDY 187 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 188 bits (478), Expect = 1e-46, Method: Composition-based stats. Identities = 56/215 (26%), Positives = 95/215 (44%), Gaps = 36/215 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ + L +++A + + +I ++ G+ + G+ LP ET + I+ Sbjct: 15 IGPEISESALSILEA-INDNFPLSLEI--KKLEAGDAVLKNTGK--ALPDETFEAIKNSD 69 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +K P+ G + + V LR+ LDLY +RP + Y PS + D+VI REN+ Sbjct: 70 ACLKAPV----GESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL---RDDVDLVIVRENT 122 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y G E+ + + SE+ +KR+ A Sbjct: 123 EDLYTGEEFDIG------------------------DAAVAFRIISEKASKRIANYAFTI 158 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A VT VHK N+MK T+G F ++A + Sbjct: 159 ASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVAND 193 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 187 bits (474), Expect = 3e-46, Method: Composition-based stats. Identities = 62/213 (29%), Positives = 104/213 (48%), Gaps = 15/213 (7%) Query: 13 VDAAVEKAYKGERKISWMEIYTG----EKSTQVYGQD----VWLPAETLDLIREYRVAIK 64 ++ A+ + I W+ G EKS +GQ +P ET+D IR + Sbjct: 30 MEGALVVLLSMDLPIDWVRADLGWCMWEKSVNKFGQGDPRCNTVPPETIDKIRSSDATLM 89 Query: 65 GPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDI 123 +T+ G G +S + +RQ DLYI LRP + SP+K D+V+FREN+ED+ Sbjct: 90 AAITSKSGVKGFKSAILQMRQLFDLYINLRPAKTLPDLGSPLKGDPKIDLVLFRENTEDL 149 Query: 124 YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 183 Y+ +E+ + + K G+++ R + + S G +R++RAA EYA + Sbjct: 150 YSAVEFHPLPEEMFNLHK------GMERFRKMGDVAVSWRVFSSVGCERIIRAAFEYAKS 203 Query: 184 NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 R V +K N+++ T+G K ++A+E Sbjct: 204 TGRTKVHCCNKANVIRETDGMMKRIFLEVAKEY 236 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 186 bits (473), Expect = 4e-46, Method: Composition-based stats. Identities = 69/217 (31%), Positives = 107/217 (49%), Gaps = 35/217 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A+L ++ A E +I I GEK + + ++ + I Sbjct: 15 IGPEIMEAVLYILRKA-------EARIRLETIEVGEKLYVKH-YSSGISEQSWESIERTG 66 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELTDMVIFREN 119 V +K P+TTP GGG +SLNV +R+ L L+ +RP V +Y T + HP ++ I REN Sbjct: 67 VILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSFYPFTKTL--HPN-LNLTIIREN 123 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 ED+YAGIE+ R + +K S G ++++R A E Sbjct: 124 EEDLYAGIEY-----------------------RQTHNMYESVKLISRTGCEKIIRYAFE 160 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 YA+ N+R VT + K NIMKF++G F ++A+E Sbjct: 161 YAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEY 197 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 184 bits (468), Expect = 2e-45, Method: Composition-based stats. Identities = 54/226 (23%), Positives = 101/226 (44%), Gaps = 44/226 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V P +K+++ E ++ G + + YG LP +T++ +E Sbjct: 12 IGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYGN--ALPEDTIEKAKEAD 61 Query: 61 VAIKGPLTTPVGG---GIRSLNVALRQELDLYICLRPVRYY-------QGTPSPVKHPEL 110 + + G +T+P G +S + LR+ LY +RP+ + + + + Sbjct: 62 IILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLNAKN 121 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+VI REN+ED+Y G E R I + + +G+ Sbjct: 122 IDIVIIRENTEDLYVGRE------------------------RLENDTAIAERVITRKGS 157 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 +R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 158 ERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY 203 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 181 bits (460), Expect = 1e-44, Method: Composition-based stats. Identities = 58/216 (26%), Positives = 92/216 (42%), Gaps = 40/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGV+V A L +++ + + ++ G+ + G LP ETL+ + E R Sbjct: 14 IGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TALPEETLEAVGEAR 64 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V LR+E DL+ LRPV+ G P D VI REN+ Sbjct: 65 ATLFGA----AGESAADVIVRLRREFDLFANLRPVKSLPGVPCLYP---DLDFVIVRENT 117 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y G E + + + + ++R+ + A +Y Sbjct: 118 EDLYVGDE------------------------EYTPEGAVAKRIITRTASRRISQFAFQY 153 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A VT VHK N++K T+G F+D Y++A E Sbjct: 154 AQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEY 189 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 179 bits (455), Expect = 5e-44, Method: Composition-based stats. Identities = 56/216 (25%), Positives = 95/216 (43%), Gaps = 39/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + V+D + + ++ G++ + +G LP ET+D++R+ Sbjct: 21 IGKEVMEATISVLD-------ELDVDFDYIYGIAGDECNEEHGTP--LPQETIDIVRDSD 71 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V +RQE+ ++ LRPV+ Y T S E D +I REN+ Sbjct: 72 ACLFGA----AGETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF---ENVDFMIVRENT 124 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y + E I + + E +R++ A +Y Sbjct: 125 EGLYI-----------------------ADQEEETEDGAIAKRVITREAEERIIDYAFQY 161 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A N+R VT VHK N++K T+G FK Y++ + Sbjct: 162 AKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKY 197 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 179 bits (454), Expect = 6e-44, Method: Composition-based stats. Identities = 54/219 (24%), Positives = 96/219 (43%), Gaps = 27/219 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++V A ++VV+ + G I + I G + +G+ ++ + LD +R++ Sbjct: 57 IGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVSEDCLDTLRKFD 112 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMVIF 116 + G + P + L +ALR L LY +RPVR + GT P+ E D ++ Sbjct: 113 AGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLNTATEGIDWMLV 172 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RENSE Y+G + G + P + + G +R++R Sbjct: 173 RENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMFTRVGIERIMRF 213 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A E A + R +T+V K N M+ + ++A++ Sbjct: 214 AFEVAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKD 252 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 178 bits (451), Expect = 1e-43, Method: Composition-based stats. Identities = 51/214 (23%), Positives = 90/214 (42%), Gaps = 36/214 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ PA +KV+DA + + + G + G + L+ I+ Sbjct: 11 IGREIIPAAVKVLDA-------FGLEFEKVPLELGYTRWERTG--TAISNNDLETIKGCD 61 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G +TT +S+ + +R+ELDLY +RPV+ G V D +I REN+ Sbjct: 62 AVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGITG-VTGRNDFDFIIVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+GIE + + +G++R+ A + Sbjct: 121 EGLYSGIE------------------------EIGPELSWTKRVVTRKGSERIAEYACKL 156 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 A ++ +T+VHK N++K ++ F D Q A Sbjct: 157 AKKR-KNKLTIVHKSNVLK-SDKLFLDVCRQTAS 188 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 177 bits (450), Expect = 2e-43, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 117/229 (51%), Gaps = 17/229 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T AM+ VV++A+E AY+G R I W +I G ++ + +G ++P +++ I++ Sbjct: 34 IGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFG--TYVPEDSIKEIQKMY 91 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+K L R LN LR+ L LY +R ++Y +G PV ++ I R+++ Sbjct: 92 IAMKSTL--NFMPDKRDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTIIRDST 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + + + S + +I+F+ + G + GI + P S+ T+++ + A+ Y Sbjct: 150 PNSHI---FYHSSESTDDLIRFISDNYG---LNITPDSGIYMMPQSKFRTRKIAKQAVRY 203 Query: 181 AIANDRDSVTLVHKGNIMKFTE------GAFKDWGYQLAR-EEFGGELI 222 + N + +T++ +F A +D GY++ + EF LI Sbjct: 204 SRRNGKKKITILESQQNHEFANWCIEEASAQEDVGYEVLKTREFMKRLI 252 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 177 bits (449), Expect = 2e-43, Method: Composition-based stats. Identities = 47/217 (21%), Positives = 94/217 (43%), Gaps = 43/217 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + V+ +K I + I ++S+ + ++ Sbjct: 98 IGPEMARHVKTVL-------HKCGAPIDFEVIDIKDESST---------DAAIISLKRNG 141 Query: 61 VAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + +KG +TT + +S+N +R++LDLY + P + G + D+V+ REN Sbjct: 142 IGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGVWT---RHGQVDLVVIREN 198 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y +E + E +K +E+ ++R+ + A + Sbjct: 199 TEGEYGSLEHENVDGVVE-----------------------SLKIITEKKSRRIAKFAFD 235 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 YA+ N+R VT +HK NIMK +G F + +++++ Sbjct: 236 YALQNNRRKVTAIHKANIMKLADGLFLETCREISKDY 272 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 176 bits (447), Expect = 4e-43, Method: Composition-based stats. Identities = 60/220 (27%), Positives = 98/220 (44%), Gaps = 28/220 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ PA +K++D A G I+W E+ G + YG+ P +TLD + E Sbjct: 34 IGPEIVPASVKILD--AAVAAAGATPIAWTELPLGRSAIDEYGEHT--PTKTLDALDEVD 89 Query: 61 VAIKGPLTTP-VGGGIRS-LNV--ALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + GP + RS LN +R+ L+ +RP + ++G + V E TD+VI Sbjct: 90 GWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNAIV---EGTDLVIV 146 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA A + + + I + T+R+ Sbjct: 147 RENTEGFYADRNTFAGTGE----------------MMPTPDVAIMHGIITRAATERIAHE 190 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + A D VT+VHK N++K T G F+D ++ ++ Sbjct: 191 AFQLARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQY 229 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 176 bits (447), Expect = 4e-43, Method: Composition-based stats. Identities = 54/217 (24%), Positives = 92/217 (42%), Gaps = 39/217 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPA--ETLDLIRE 58 IG ++ A+ + + + E+ + +D +L A E + I+ Sbjct: 61 IGPEMVVAVQDIFR-------HIGVPVDFEEL--NLSGLDIKDEDSYLGAFNEAITSIKR 111 Query: 59 YRVAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 VA+KG + TP+ G RSLN+ LR LDL+ + + G + D+VI Sbjct: 112 NGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT---RHNNVDLVII 168 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 R+N+E Y+ +E + S E + K +EE ++ + Sbjct: 169 RQNTEGEYSHLEHENVSGVIENL-----------------------KVTTEEACMKIAQY 205 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 A ++A +DR VT VHK NIMK +G F +++ Sbjct: 206 AFDFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMS 242 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 175 bits (445), Expect = 6e-43, Method: Composition-based stats. Identities = 53/220 (24%), Positives = 91/220 (41%), Gaps = 28/220 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A ++V+ +A + +K + + ++ G S + YG L E L + Y Sbjct: 11 IGPEIVGAAMEVLRSA-DSVFKLDLAFDYDDV--GFTSLEKYG--TTLRDEVLAKAKTYD 65 Query: 61 VAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 I G + P GG R+++ R LDLY +RP R S ++ D+VI Sbjct: 66 GVILGTQSHADYPAPDKGG-RNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTMDLVI 124 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RE +E Y A+ + I ++ + ++R+ R Sbjct: 125 MREATEGFYPDRNMTKGWAE----------------LMPSPDMAISLRKITRHCSERIAR 168 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A E A+ + VT +HK N T+G F + +AR+ Sbjct: 169 RAFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARD 207 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 175 bits (443), Expect = 1e-42, Method: Composition-based stats. Identities = 62/215 (28%), Positives = 97/215 (45%), Gaps = 37/215 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIY-TGEKSTQVYGQDVWLPAETLDLIREY 59 IG + + A+ ++ A I + EI TG + D E + ++ Sbjct: 31 IGRETSNAVTEIFKTA-------NVPIEFEEIDVTGMEKNNKSSGDAL--HEAIQSLKRN 81 Query: 60 RVAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 +V +KG L TP GG S NVALR+ELD+Y L ++ G + + D I RE Sbjct: 82 KVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT---RHDNVDFAIIRE 138 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+G+E ++ E +K +E +KR+ + A Sbjct: 139 NTEGEYSGLEHQSVPGVVE-----------------------SLKIITEYKSKRIAQFAF 175 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 176 DFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVA 210 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 174 bits (442), Expect = 1e-42, Method: Composition-based stats. Identities = 52/220 (23%), Positives = 91/220 (41%), Gaps = 28/220 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A L+V++A ++ G+ I G + G V +PA+ L+ ++++ Sbjct: 14 IGPEVIAAGLQVLEALEKR--SGDFSIHTETFDWGSDYYKKNG--VMMPADGLEQLKKFD 69 Query: 61 VAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 G + P L + + Q D Y +RP + G P+++ P D VI Sbjct: 70 AIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGPGDLDWVI 129 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RENSE Y+G +A PE G + + G R++R Sbjct: 130 VRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVAIFTRVGVTRIMR 170 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A + A A R +T+V K N + + + ++++E Sbjct: 171 YAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKE 210 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 173 bits (439), Expect = 3e-42, Method: Composition-based stats. Identities = 55/216 (25%), Positives = 88/216 (40%), Gaps = 41/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ + +V I + E+ ++S D L ++ Sbjct: 79 VGPELLSYVKEVFQ-------VIGAPIDFEEVAVNQESEDATFTDALL------AMKRNG 125 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKG T G S NVALR L+LY ++ R + G V + D+VI REN+ Sbjct: 126 VGIKGNFATE--PGQSSRNVALRLNLNLYAFVQRCRNFPGV---VTRHQNVDIVIIRENT 180 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+ +E + E +K + E + R+ + A +Y Sbjct: 181 EGEYSRLEHENVPGVVE-----------------------SLKIITREKSTRIAQFAFDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A+ ++R VT VHK NIMK +G F D +A+ Sbjct: 218 AVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNY 253 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 173 bits (439), Expect = 4e-42, Method: Composition-based stats. Identities = 65/205 (31%), Positives = 98/205 (47%), Gaps = 13/205 (6%) Query: 11 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 70 +V +A I+W + G + Q LP D+IR + A+ GPL P Sbjct: 16 QVTNALQMAIAATGVDITWQIVDIGGE-----DQQGLLPNYIFDIIRTAKTAVIGPLMMP 70 Query: 71 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 130 R + +R++LDLY+ LRP + G PS + D++I RE +E IYAGIE++ Sbjct: 71 --DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNY---QNVDIMIVRETTEGIYAGIEFE 125 Query: 131 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 190 S +A FL + G R E +GIKP S +G +++ A YA R V Sbjct: 126 RTSVEAADARSFLSKLSGK---RIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQVI 182 Query: 191 LVHKGNIMKFTEGAFKDWGYQLARE 215 VH+ + M T+G F + +A+E Sbjct: 183 AVHQAHFMAHTDGLFLEIARDIAQE 207 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 173 bits (438), Expect = 4e-42, Method: Composition-based stats. Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 28/219 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ P ++V+ AA + I W +I G + G LP T++ + Sbjct: 11 IGHEIVPEAVRVMQAAAAR---TGLAIEWQDIPIGRAALDSLGST--LPDGTIERLDALD 65 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + GP+ P + + LR+ DL+ +RPV+ + P + D+VI R Sbjct: 66 GWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL---HQGVDLVIVR 122 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+E A S + R I ++ + G+ ++ RAA Sbjct: 123 ENNEGFQPDRNVVAGSGE----------------FRPTPDVTISVRVITRNGSSKVARAA 166 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 E A A R +T VHK + K G F + +LA E Sbjct: 167 FELARAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAEY 204 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 172 bits (436), Expect = 8e-42, Method: Composition-based stats. Identities = 48/198 (24%), Positives = 83/198 (41%), Gaps = 29/198 (14%) Query: 17 VEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR 76 VE + + E Y + + + + + A+KG T +G + Sbjct: 65 VEVFQNSGVPVDFEECYITGDTNEEKMKSF---NDIKTSVLRNGTALKGNWATSMGIDSK 121 Query: 77 SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADA 136 S NV LR +LDLY + + Y P+ + D+++ REN+E Y +E + Sbjct: 122 SYNVLLRHDLDLYANVVKFKSY---PTVITRHNNVDLIVIRENTEGEYTNLEHENIPGVI 178 Query: 137 EKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGN 196 E IK +++ ++R+ + A +YA+ N+R VT VHK N Sbjct: 179 EM-----------------------IKIITKKKSERIAKYAFDYAMENNRKKVTAVHKAN 215 Query: 197 IMKFTEGAFKDWGYQLAR 214 IMK ++G F ++A Sbjct: 216 IMKLSDGLFLKVCKEVAE 233 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 172 bits (435), Expect = 1e-41, Method: Composition-based stats. Identities = 60/227 (26%), Positives = 100/227 (44%), Gaps = 47/227 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A ++V++A + W I +++ ++YG LP + + I++ + Sbjct: 11 IGPEITAATIRVIEA-------TGIQPEWDFIPIADEAVRLYGH--ALPPQVIQRIKDVK 61 Query: 61 VAIKGPL----------TTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 IK PL T G S+N A+R+EL+L++ RP+R Y G Sbjct: 62 FCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISG---R 118 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 E DMVI RE +ED Y G E + A + IK + Sbjct: 119 HEKMDMVIMREITEDTYIGWEKPLEDGAAAE----------------------AIKRVTR 156 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 157 SASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVAR 203 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 171 bits (434), Expect = 1e-41, Method: Composition-based stats. Identities = 54/225 (24%), Positives = 106/225 (47%), Gaps = 38/225 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKG---ERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 57 IG +V PA ++V++AA+ K K + + ++ + G ++ Q G+ LP ET++ ++ Sbjct: 42 IGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKS--LPVETVEALK 99 Query: 58 -EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 + AI G + +P G S VA+R+ +DLY +RP + + DM+ Sbjct: 100 NKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPCQDLA---------KGIDML 150 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 I REN+E +Y E E + + +E +KR+ Sbjct: 151 IVRENTECLYIKKEKLTVDPTT------------------GEKTAVADRLITERASKRIA 192 Query: 175 RAAIEYAIANDRD---SVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + A+ +++ VT+VHK N++ ++G F++ +++++ Sbjct: 193 EIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKY 237 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 57/223 (25%), Positives = 91/223 (40%), Gaps = 45/223 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A + ++A I W ++ G ++ Q G V++ +D E Sbjct: 44 IGREIVSAAKECIEA-------TGVNIRWEQMDMGYEAMQNTG--VYIDDSHMDAFEEIG 94 Query: 61 VAIKGPLTTPV----------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 110 V KGPLT P G S N R+ L+ +RPVR G +P Sbjct: 95 VLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVRAPF---ND 151 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+V+ REN+ED+Y G E D+ +K S + Sbjct: 152 VDLVVIRENTEDVYTGEETWVDADTVH-----------------------CVKRISRGAS 188 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 +R+ + +YA N R VT +HK N+ K ++G F + ++ A Sbjct: 189 ERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERA 231 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 49/218 (22%), Positives = 86/218 (39%), Gaps = 41/218 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + V A + + E++ + + ++ + IR R Sbjct: 27 IGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEEDIRNAIM------AIRRNR 73 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + T + +S N LR LDLY + + G V + D++I RE Sbjct: 74 VALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV---VTRHKDIDILIVRE 130 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+ +E ++ + E +K ++ + R+ A Sbjct: 131 NTEGEYSSLEHESVAGVVE-----------------------SLKIITKAKSLRIAEYAF 167 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + A + R VT VHK NIMK +G F ++A Sbjct: 168 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY 205 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 170 bits (431), Expect = 3e-41, Method: Composition-based stats. Identities = 49/218 (22%), Positives = 86/218 (39%), Gaps = 41/218 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + V A + + E++ + + ++ + IR R Sbjct: 65 IGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEEDIRNAIM------AIRRNR 111 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + T + +S N LR LDLY + + G V + D++I RE Sbjct: 112 VALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV---VTRHKDIDILIVRE 168 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+ +E ++ + E +K ++ + R+ A Sbjct: 169 NTEGEYSSLEHESVAGVVE-----------------------SLKIITKAKSLRIAEYAF 205 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + A + R VT VHK NIMK +G F ++A Sbjct: 206 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY 243 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 170 bits (431), Expect = 3e-41, Method: Composition-based stats. Identities = 51/220 (23%), Positives = 86/220 (39%), Gaps = 28/220 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + + E G + + G + +G V +PA+ L+ +R+ Sbjct: 14 IGKEVIPAGRQAMQVLAET--DGSFTFEFQDFDWGGDYYRRHG--VMMPADGLEPLRDKD 69 Query: 61 VAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 + G P + L + + Q LD Y +RP R G P+K E D VI Sbjct: 70 AILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLKRCTAEQLDWVI 129 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RENSE Y+G+ + P + + G +R++R Sbjct: 130 VRENSEGEYSGVGGRVHQG-------------------LPIEAATDVSMMTRAGVERILR 170 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A A + R +T+V K N + + + +++RE Sbjct: 171 YAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISRE 210 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 170 bits (431), Expect = 3e-41, Method: Composition-based stats. Identities = 52/216 (24%), Positives = 92/216 (42%), Gaps = 38/216 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A+ +V AA E +S ++ E+ + + L ++E + Sbjct: 59 VGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLE----------QVLSSMKENK 108 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VAI G + TP G + S ++ LR++LDL+ + V+ G + D+VI RE Sbjct: 109 VAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT---RHNNLDLVIIRE 165 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 +E Y+ +E ++ E +K + ++R+ + A Sbjct: 166 QTEGEYSSLEHESARGVIE-----------------------CLKIVTRAKSQRIAKFAF 202 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 +YA R VT VHK NIMK +G F ++A Sbjct: 203 DYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAE 238 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 170 bits (431), Expect = 3e-41, Method: Composition-based stats. Identities = 58/214 (27%), Positives = 90/214 (42%), Gaps = 33/214 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A+L ++ A + + I + G + P + I R Sbjct: 18 VGPEIMEAVLFILKEA-----RADVSIET--VDIGHNQYKKEWTSGIAP-SAWESISRTR 69 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +K P TP G G +SLNVALRQ L LY+ +RP Y P D+VI REN Sbjct: 70 LLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSY--FPVVGTKHPDLDVVIIRENE 127 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED Y+G+E + E +K + ++++ A Y Sbjct: 128 EDTYSGVEH-----------------------KLSEDTHECVKISTRSASEKICAYAFNY 164 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 A A++R VT K NIMK T+G ++A+ Sbjct: 165 ARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAK 198 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 169 bits (427), Expect = 8e-41, Method: Composition-based stats. Identities = 52/218 (23%), Positives = 102/218 (46%), Gaps = 40/218 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++T ++ + +A I W I + + + V+ E ++ ++ + Sbjct: 39 VGKEITDSVRTIFEA-------ENIPIDWETINIKQT---DHKEGVY---EAVESLKRNK 85 Query: 61 VAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + +KG TP G SLNVALR++LD+Y + + +G + + D+++ REN Sbjct: 86 IGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP---DIDLIVIREN 142 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E ++G+E ++ E +K + T+R+ R A + Sbjct: 143 TEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTERIARFAFD 179 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 +A +R SVT VHK NIMK +G F++ ++ ++E+ Sbjct: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEY 217 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 167 bits (422), Expect = 3e-40, Method: Composition-based stats. Identities = 64/220 (29%), Positives = 102/220 (46%), Gaps = 36/220 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +T ++++ ++ + ++ G + + +PAE L ++E Sbjct: 52 IGPAITSQAQRILEYLLKDDILQGK--VEFKVIDGLTIERRAAEHAAIPAEVLKELKECH 109 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 V +KGP TTP G S NVA+R+ELDL+ +RPVR + + D + Sbjct: 110 VILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE---------QGIDWTFY 160 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA +G K I E G+ + G++R++RA Sbjct: 161 RENTEGAYA---------------------VGSKGIHVTEDLGVDFTVVTSGGSERIIRA 199 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A EYA AN + VT V K NI+K T+G F D ++A++ Sbjct: 200 AFEYAKANGKTRVTAVTKANIIKTTDGKFLDIFREIAKDY 239 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 167 bits (422), Expect = 3e-40, Method: Composition-based stats. Identities = 54/219 (24%), Positives = 96/219 (43%), Gaps = 29/219 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++V++AA ++ ++ + +I G S Q +G V L+ ++ Sbjct: 11 IGPEIMAVAVRVLEAASKR-FQLDLEIGHD--IAGHASLQRHGATVT--PALLEKVKAAD 65 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + GP+ T G + + R+ELDLY +RP R + G V ++ + Sbjct: 66 GLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAHRV---GEFNLAVV 122 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA E G ++ I ++ + +R+ R+ Sbjct: 123 RENTEGFYADRN----------------IESGSSEMLITPDTVISLRRITRLCCERIARS 166 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A + A R V++VHK N++K +G F D Q+ARE Sbjct: 167 AFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVARE 204 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 165 bits (419), Expect = 7e-40, Method: Composition-based stats. Identities = 61/221 (27%), Positives = 92/221 (41%), Gaps = 30/221 (13%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G + LKV+ AA A K + + G + G+ LP + ++ ++ Y Sbjct: 28 GPEQVREGLKVLHAA---AGKEGFALETTVLDWGGEYYLRTGE--VLPPDAVEQLKRYDA 82 Query: 62 AIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVIF 116 G + P G + + + LR ELD YI LRPV+ Y G +P+ K PE D V+ Sbjct: 83 IYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKLYPGVETPIAGKGPEDIDFVVV 142 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E +YAG G K P+ I + +G +R VR Sbjct: 143 RENTEGLYAG-------------------SGGFLKRGTPDEVAIQTSINTRKGVERCVRF 183 Query: 177 AIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A EY R VTL K N++ F ++ ++ E Sbjct: 184 AFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEY 224 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 165 bits (419), Expect = 8e-40, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 102/240 (42%), Gaps = 35/240 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG V P ++V++A +A I W + LP T+ L+R+++ Sbjct: 14 IGNQVLPQAIRVLEAVGFEANYVHADIGWECW---------CNEGNALPDRTIQLLRKHK 64 Query: 61 VAIKGPLTTPVGG---------------GIRSLNVALRQELDLYICLRPVRYYQGTP--- 102 + + G +T+ S V +RQ +L +C+RP + G P Sbjct: 65 LGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNF 124 Query: 103 ------SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPE 156 + P+ D+V+FR+N+E +YAG+EW + + ++ E Sbjct: 125 IRQTTCGGFEEPQ-VDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFANTP-GE 182 Query: 157 HCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + ++ +++ +R+ AA ++A +VT+ K N+++ T G ++ Q+ ++ Sbjct: 183 ELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQY 242 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 165 bits (418), Expect = 1e-39, Method: Composition-based stats. Identities = 55/217 (25%), Positives = 92/217 (42%), Gaps = 39/217 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA +V++A + ++E G ++ + G V P ET++ I Sbjct: 13 IGHEVIPAARRVLEA-------TGLPLEFVEAEAGWETFERRGTSV--PEETVEKILSCH 63 Query: 61 VAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 + G T+P G LR+ LDLY +RP + P P P D+VI RE Sbjct: 64 ATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKSR---PVPGSRPG-VDLVIVRE 119 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E +Y E + I S++ ++R+ RAA+ Sbjct: 120 NTEGLYVEQERRY------------------------LDVAIADAVISKKASERIGRAAL 155 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A R ++ + HK N++ T+G F D ++A++ Sbjct: 156 RIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKD 192 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 164 bits (416), Expect = 2e-39, Method: Composition-based stats. Identities = 61/227 (26%), Positives = 93/227 (40%), Gaps = 46/227 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + V+ A + G + Q G+ LP+ TL R Sbjct: 16 IGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGE--ALPSATLTAARAAD 66 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL--TDMVIF 116 + G + +P G RS V LR+ELDLY +RPV + P +P D+V+ Sbjct: 67 AILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNPRRRKVDLVVV 124 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+ED+YAG E D I + + + R++R Sbjct: 125 RENTEDVYAGRERVEDDGAT----------------------AIAERVITRRASARIMRV 162 Query: 177 AIEYAIANDR---------DSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 A + A A VT+VHK N+++ T G F+ ++A+ Sbjct: 163 ACDLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQ 209 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 164 bits (416), Expect = 2e-39, Method: Composition-based stats. Identities = 58/216 (26%), Positives = 93/216 (43%), Gaps = 40/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A L +++ Y G ++EI G+ G+ + ++ IRE Sbjct: 11 VGPEIMGATLSLLE-----RYIGA---DFIEIKAGKSYFIEEGKP--IEDNAIEKIRECD 60 Query: 61 VAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +KGP+ TP G S+N LR+E LY +RP R Y+G D ++ REN Sbjct: 61 SLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGISI-----RRIDTILVREN 115 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 E +Y G E + E I ++ ++ G +R+ A Sbjct: 116 LECLYYGWEVE------------------------DEDRAIAMRVITKRGAERISEFAFN 151 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A R VT +HK NI+K T+G F D Y++A + Sbjct: 152 LAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVASK 187 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 164 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 44/167 (26%), Positives = 72/167 (43%), Gaps = 28/167 (16%) Query: 52 TLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 + IR RVA+KG + T + +S N LR LDLY + +++ P V + Sbjct: 19 AIMAIRRNRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANV---IHWKSLPGVVTRHK 75 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D++I REN+E Y+ +E ++ + E +K ++ Sbjct: 76 DIDILIVRENTEGEYSSLEHESVAGVVE-----------------------SLKIITKAK 112 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + R+ A + A + R VT VHK NIMK +G F ++A Sbjct: 113 SLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY 159 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 164 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 46/222 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLD----LI 56 IG ++ + K+ A + + E K T P LD I Sbjct: 55 IGPEMLDIVQKIFTFA-------NVPVDFEECQLDSKPTS--------PESDLDNAIMSI 99 Query: 57 REYRVAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 + VAIKG + T +S NV LR+ LDL+ + P+ K ++V+ Sbjct: 100 QRNGVAIKGNIETKYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPTRHKG---INIVM 156 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E Y+G E + + E +K C+ E +R+ R Sbjct: 157 IRENTEGEYSGHEHETVNGVVE-----------------------SLKICTREKLERISR 193 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A +YAIA++R +T VHK NI K +G F ++A +E+ Sbjct: 194 FAFDYAIAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEY 235 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 163 bits (413), Expect = 3e-39, Method: Composition-based stats. Identities = 52/217 (23%), Positives = 88/217 (40%), Gaps = 39/217 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + + + I + + + + + + I+ Sbjct: 67 IGPECMGYVRDIF-------KYIGAPIDFEVVDI-DPTMDNDDDVQY----AITTIKRNG 114 Query: 61 VAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 V +KG + T S NVALR ELD+Y + + Y G + + D+VI R+N Sbjct: 115 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQN 171 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E YA +E ++ + E +K + + ++R+ R A E Sbjct: 172 TEGEYAMLEHESVNGVVE-----------------------SMKVVTADNSERVARFAFE 208 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 +A N R VT VHK NIMK ++G F + +LA+E Sbjct: 209 FAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEY 245 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 163 bits (412), Expect = 5e-39, Method: Composition-based stats. Identities = 54/221 (24%), Positives = 93/221 (42%), Gaps = 35/221 (15%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G + P M++ V+A G+ + + I G + + IR V Sbjct: 55 GHGIGPEMMRHVEAIFAC---GKVPVDFETIIVDAN----VGDASSM-DHAIKSIRRNGV 106 Query: 62 AIKGPL-TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 A+KG + TT + N+ LR +L+LY+ + R + G + + D+V+ R+N+ Sbjct: 107 ALKGNIETTSYSMTVEPRNLLLRNKLELYVNVVHCRNHPGINT---KHKGVDIVVIRQNT 163 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+ +E + S E +K + + ++ + EY Sbjct: 164 EGEYSCLEHEVTSGVVE-----------------------SLKIITWAKSFQIAKYCFEY 200 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A + R VT+VHK NIMK T+G F ++A+E EL Sbjct: 201 ARTHMRKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIEL 241 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 160 bits (404), Expect = 4e-38, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 93/224 (41%), Gaps = 19/224 (8%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT +KV++AA + G + Q LP L+ + Sbjct: 14 IGPEVTAQAVKVMEAAGSLF---GFSLELTHYPYGAEHYLSTRQ--VLPDHALEEMEGLD 68 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P G R + + LR D Y +RPVR + P P+ + V+ R Sbjct: 69 ALLLGAIGDPRVQPGILERGILLKLRFHFDQYANIRPVRSFT--PGPL---GSVNAVVIR 123 Query: 118 ENSEDIYAGIEWKADSA-----DAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 EN+ED+Y GI D A + + ++ ++ P+ + + + +G R Sbjct: 124 ENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTP-PKRFAMQVAWHTLDGAAR 182 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + A + A+ + VTL K N ++ G F++ +Q+A + Sbjct: 183 ACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQY 226 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 159 bits (401), Expect = 8e-38, Method: Composition-based stats. Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 32/230 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A + V+ AA+ K Y + + + EI G S + + +E L + + Sbjct: 14 IGPEIAKASVDVLQAAL-KLYDLKVNLVYEEI--GFASLKKH--KTTFRSEVLKIAEKCD 68 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 I G + P G + + +R+ DLY +RP + G + P D ++ Sbjct: 69 GMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLG--KLERFPMGIDCLVM 126 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+ + + I I+ + +G+ R+ Sbjct: 127 RENTEGFYSDRNMFKGVGE----------------LMPTPDVAISIRNITRKGSTRIAEI 170 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELI 222 +YA+ R + +HK N++++++G F + Q++++ E+ +++ Sbjct: 171 GFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIV 219 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 51/220 (23%), Positives = 87/220 (39%), Gaps = 33/220 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V P ++V++AA K + + + + + + Q +P++ ++ +R+ Sbjct: 17 IGNEVVPEGIRVLEAASAK-FGFKLAFTTYD----WSCARYHSQGSMMPSDGIERLRDSD 71 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVI 115 G + P + +L + +R+E D Y+ LRPVR G P P+ K P D I Sbjct: 72 AIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANKKPGDIDFWI 131 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E Y+ + G + GT R++R Sbjct: 132 VRENTEGEYSQVG-------------------GRMFAGTEHEFVTQEAIFTRRGTDRIMR 172 Query: 176 AAIEYAIANDRDSVTLVHKGN----IMKFTEGAFKDWGYQ 211 A + A R+ VT K N M F + F G + Sbjct: 173 YAFDLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAE 212 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 54/213 (25%), Positives = 89/213 (41%), Gaps = 37/213 (17%) Query: 14 DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGG 73 + +V + + + E++ + +G+D LP T D IRE +A+K L P G Sbjct: 17 ELSVRRLFAAAKVPVEFEVHLAGRMALEHGKDA-LPKATFDAIRECGLALKTKLLQPKGV 75 Query: 74 GI----------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDI 123 G+ + NVA R++L L+ +RPV G PS D ++FRE +ED+ Sbjct: 76 GMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSRFTG---VDFLLFREITEDL 132 Query: 124 YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIA 183 Y E + + K +E R + A + A Sbjct: 133 YTASEHEIVPGVVQ-----------------------SFKIVTEAACLRFFKLAFDTARK 169 Query: 184 NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 R +V +HK NI+K +G F + Y++A+E Sbjct: 170 RGRKTVHCIHKANILKMADGLFLECFYRVAKEY 202 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 55/225 (24%), Positives = 88/225 (39%), Gaps = 30/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + + AA+E ++ G + G +P + DL+++ Sbjct: 18 IGPEVVAATVPALRAALE---ADGHRLDVTSFDWGGERYLRQG--AAMPPDAADLVKKTD 72 Query: 61 VAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P L + LRQ+LDL + LRPVR + G P+ V+ + D+VI R Sbjct: 73 AVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDTDGVDLVIVR 132 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+E Y G GV GI + S +R A Sbjct: 133 ENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRRAIERAAHQA 173 Query: 178 IEYA-IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A + R + LV K N M++ + ++ + G EL Sbjct: 174 FALAGRRSGR--LCLVTKSNAMRYGYPLWDRVVREVGEQYPGVEL 216 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 51/215 (23%), Positives = 86/215 (40%), Gaps = 38/215 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ L+V+ AA +S G E L IR R Sbjct: 48 IGPEIMDHTLRVLKAAGAPLSYEIFALS-----------SKDGSKNNDFDEALTSIRRNR 96 Query: 61 VAIKGPLT-TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 VA+KG + I+S N+ R+ LDL++ + + + G D+ + R+N Sbjct: 97 VALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGL---SNKFGEIDITVIRQN 153 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y +E + + E +K + +RL+ A + Sbjct: 154 TEGEYLMLEHEPRTGSVE-----------------------SLKVLTRFNLERLIEFAFD 190 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 YA+ NDR +T+VH NI K TEG F + ++++ Sbjct: 191 YALTNDRKLITVVHNANIQKLTEGLFLNAANKISK 225 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 156 bits (394), Expect = 6e-37, Method: Composition-based stats. Identities = 57/228 (25%), Positives = 107/228 (46%), Gaps = 38/228 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIRE-Y 59 IG +V PA +V++ K +++++Y G ++ Q G+ LP ET+ +++E Sbjct: 34 IGKEVIPAGKQVLE---NLNSKHGLSFNFIDLYAGFQTFQETGK--ALPDETVKVLKEQC 88 Query: 60 RVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + A+ G + +P G S VALR+E+ L+ +RPV+ +G + DMVI R Sbjct: 89 QGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEGEKG-----KPIDMVIVR 143 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+ED+Y IE K SE T+R+ A Sbjct: 144 ENTEDLYIKIEKTY------------------IDKATGTRVADATKRISEIATRRIATIA 185 Query: 178 IEYAIA----NDRDSVTLVHKGNIMKFTEGAFKDWGYQL---AREEFG 218 ++ A+ + ++T+ HK N++ ++G F++ ++ ++++G Sbjct: 186 LDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYG 233 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 155 bits (392), Expect = 1e-36, Method: Composition-based stats. Identities = 47/217 (21%), Positives = 84/217 (38%), Gaps = 37/217 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA V++A K ++E G ++ + G V P TL+ + Sbjct: 15 IGHEVIPAARLVLEA-------TGLKFEFVEAQAGWETFERIGTSV--PEATLEAVTHTD 65 Query: 61 VAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 + G T+P G +R++LDL+ +RP +++ P P P D+++ RE Sbjct: 66 ATLFGAATSPTKKVPGFFGAIRYMRRKLDLFANVRPAKHH---PVPGSRPG-VDLIVVRE 121 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E +Y E + I + + + R+ A Sbjct: 122 NTEGLYVEQERSYLEGE----------------------IAIADTVITRKASARIGEYAA 159 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A + R + + HK N++ T+G F + A Sbjct: 160 RLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAAR 196 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 155 bits (392), Expect = 1e-36, Method: Composition-based stats. Identities = 59/210 (28%), Positives = 96/210 (45%), Gaps = 37/210 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD--VWLPAETLDLIRE 58 IG +V +ML+V+ E ++ E + G + G+ ++P T+ ++ E Sbjct: 13 IGPEVVDSMLRVL---KECNFQSELIL----CEAGSEQWDKNGRKDASYIPDVTMKILEE 65 Query: 59 YRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 KGP TT PV G RS+ V LRQ+ DLY +RP + Y K D V FR Sbjct: 66 TDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLTPDRK----LDCVCFR 121 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 E +E +Y G+E + + I I+ + +G++RL+ +A Sbjct: 122 EATEGLYTGVE-----------------------AKITDDAAIAIRKITRQGSRRLIDSA 158 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKD 207 +++A + + V K NI+K T+G F D Sbjct: 159 VDWANKFNMKKMVAVTKRNILKQTDGIFWD 188 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 154 bits (390), Expect = 2e-36, Method: Composition-based stats. Identities = 47/226 (20%), Positives = 101/226 (44%), Gaps = 15/226 (6%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V KV+ AA ++ Y + + W+++ G+ + +L + +YR Sbjct: 14 IGPEVIAEGRKVI-AAAQEVYNFD--VEWIDMPFSADHYVKTGET--ISESSLKELSKYR 68 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE--LTDMV 114 G + G + + + +R D Y+ LRPV+ +G +P+K D Sbjct: 69 AIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAADIDFY 128 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCGIGIKPCSEEGT 170 + REN+ED Y GI ++ +++ ++ +R+ + G+ + + S+EG Sbjct: 129 VVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQLGVVSKEGA 188 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 KR++ + + A + + ++ V K N++ G +++ A + Sbjct: 189 KRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKY 234 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 153 bits (387), Expect = 4e-36, Method: Composition-based stats. Identities = 55/221 (24%), Positives = 91/221 (41%), Gaps = 36/221 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V K +DA E I+W ++ G +G +PA+ +D++R + Sbjct: 11 VGPEVMAEARKALDAL-------ELGIAWTDVPWGSAWWAEHG--TMMPADAIDVLRGHD 61 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVI 115 + G + P + L + +RQELDL++ +RP R +G P P+ + P DMV Sbjct: 62 AILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAPHDVDMVF 121 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RENSE YAG+ + F I + G +R++R Sbjct: 122 VRENSEGEYAGVGGRVHRG-------------------FGHDVAIESSVFTRRGCERVIR 162 Query: 176 AAIEYAIANDRDSVTL-VHKGNIMKFTEGAFKDWGYQLARE 215 A A A R V + K N +F + + ++ E Sbjct: 163 YAFGMASA--RKGVLVNATKSNASRFGFPFWDEIVAEVGAE 201 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 153 bits (386), Expect = 5e-36, Method: Composition-based stats. Identities = 61/222 (27%), Positives = 91/222 (40%), Gaps = 36/222 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + L+V ++ K+ + I G + ++ LPAE L+ + Sbjct: 57 IGPCIMEQALRVAKYLLKDEMASG-KVEFRTIP-GMTIEERVQKNESLPAEVLEACKACD 114 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 V +KGP TP G S N LR+ L LY +RPVR + + D F Sbjct: 115 VLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE---------KGIDWTFF 165 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN E Y G K I+ + + K + G +R+ RA Sbjct: 166 RENIEGEYI---------------------WGNKGIQVDDDLAVDFKVLTRPGAERICRA 204 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 A E+A N + +VT+V K NI+K +G F + L +E G Sbjct: 205 AFEFAKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEYPG 246 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 152 bits (384), Expect = 9e-36, Method: Composition-based stats. Identities = 51/220 (23%), Positives = 88/220 (40%), Gaps = 31/220 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVT A ++V+ AA KG + +G+ +P + ++ +R + Sbjct: 14 IGVDVTDAAMEVLGAAA----KGRFAFDTTSFPWSCEYYLEHGR--MMPEDGIETLRGFD 67 Query: 61 VAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 G P T P + L + +R+ + Y +RP R G P+K E D++ Sbjct: 68 AIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK-AEGFDILCI 126 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+G + +V + + G +R++R Sbjct: 127 RENTEGEYSGAGGRVHEGKGNEV-------------------AVETSVFTRAGVERILRF 167 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 E A + R +T V K N K++ + + +LA E Sbjct: 168 GFEQARSR-RGHLTSVTKSNAQKYSMVFWDEVTRELAAEY 206 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 152 bits (383), Expect = 1e-35, Method: Composition-based stats. Identities = 60/223 (26%), Positives = 85/223 (38%), Gaps = 32/223 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V L+V+ AV + + + G GQ L L + ++ Sbjct: 15 IGPEVVHEALRVLREAV----PADVSLDTTQYPFGAGHFLETGQ--ILTDSDLAALAQHD 68 Query: 61 VAIKGPLT-TPVG----GGI--RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 + G + P GGI R L + LR D YI LRP G SP+ P D Sbjct: 69 AILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVASPLAAPGQVDF 128 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 V+ RE +E YAG GV + + + G +R Sbjct: 129 VVVREGTEGPYAG-------------------NGGVLRRGTEHEIATEVSVNTAHGVERT 169 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 VR A E A DR VTLVHK N++ F ++ ++A E Sbjct: 170 VRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEH 212 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 152 bits (383), Expect = 1e-35, Method: Composition-based stats. Identities = 47/168 (27%), Positives = 74/168 (44%), Gaps = 26/168 (15%) Query: 50 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP- 108 + I +V +KGP T +S++ L + LY + PV+ Q P V P Sbjct: 130 PDLHQSILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPF 187 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 DMV+ REN+E Y+G+E + E +K + + Sbjct: 188 RDVDMVVVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRD 224 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 G+ R+ + A EYA + R V +HK NIMK ++G F + Q+A+E Sbjct: 225 GSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEY 272 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 150 bits (380), Expect = 3e-35, Method: Composition-based stats. Identities = 57/226 (25%), Positives = 91/226 (40%), Gaps = 36/226 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA L++V+AA A G +++ G + G LPA TLD R+ Sbjct: 18 IGREVMPACLELVNAATTMA--GAPALAFQTHNAGAQYYAESGD--ALPASTLDACRKSD 73 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDMV 114 + G + P G + LR EL L+ +RP+R++ G P + P E D V Sbjct: 74 AILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPRAEQIDFV 133 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE +E ++ G +IR E + GT+R+ Sbjct: 134 LVREQTEGLFYAR--------------------GRGEIRNDEE-AYDTMQITRSGTQRVT 172 Query: 175 RAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + A R +VT V K N+ + + F+ ++A Sbjct: 173 EFAFDIARQRKRRGKPGNVTCVDKANVFQ-SMAFFRKVFDEVADRH 217 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 148 bits (373), Expect = 2e-34, Method: Composition-based stats. Identities = 51/224 (22%), Positives = 86/224 (38%), Gaps = 29/224 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V A KV+ A E G S+ +G+ +P + + + ++ Sbjct: 16 VGKEVVAAAEKVLHTAAEV--HGGLSFSFTAFPWSCDYYLEHGK--MMPEDGIHTLTQFE 71 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 G + P + L + +R+EL+L I +RP + G SP+ HP D V+ Sbjct: 72 AVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLLHPNDFDFVVI 131 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RENSE Y+ + + D + I + + T+R++R Sbjct: 132 RENSEGEYSEVGGRIHRGD--------------------DEIAIQNAVFTRKATERVMRF 171 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A E A R VT K N + + + Q A + G E Sbjct: 172 AFELAKKR-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIE 214 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 147 bits (372), Expect = 2e-34, Method: Composition-based stats. Identities = 53/242 (21%), Positives = 85/242 (35%), Gaps = 50/242 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +++A E + + EI G + +G W P + R Sbjct: 20 IGPEVMAQARDLLEAVAEPS---GVRFELDEIPCGGRFYLEHGARDW-PEDAEARCRGAD 75 Query: 61 VAIKGPLTTPVGGGI------------RSLNVALRQELDLYICLRPVRYYQGTPSPVK-- 106 V + G + P G S + R +LDLY +RPV+ G + Sbjct: 76 VILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGVAHRISGT 135 Query: 107 -----HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 161 PE DMVI REN+E +YAG+ G ++ Sbjct: 136 RQQVWRPEHVDMVILRENTEGLYAGMG-------------------GQLRVGGSASVATD 176 Query: 162 IKPCSEEGTKRLVRAAIEYAIANDR-------DSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 + + G +R++R A E R VT + K N++ F + ++A Sbjct: 177 TRLITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVL-EGCKLFAEVFAEVAS 235 Query: 215 EE 216 E Sbjct: 236 EY 237 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 147 bits (371), Expect = 3e-34, Method: Composition-based stats. Identities = 44/216 (20%), Positives = 79/216 (36%), Gaps = 45/216 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T ++ V +A + + + ++ +R+ Sbjct: 43 IGPEITNSVKTVFEAL--------------HVPIKFDVLDNFNFEN---DDSKSQLRKNE 85 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G + T N + LDLY + +G + TD+V+ REN+ Sbjct: 86 CILLG-VMTEKNQKYTD-NYKFYKYLDLYSNITFAFSVEGIT---QRHNNTDIVVIRENT 140 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+G+E + E IK +++ + R+ A E+ Sbjct: 141 EGEYSGVEHEVYPGVVE-----------------------SIKVTTKQASLRIAEYAFEF 177 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + R VT VHK NIMK +G F ++A+ Sbjct: 178 AHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRY 213 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 147 bits (371), Expect = 3e-34, Method: Composition-based stats. Identities = 49/216 (22%), Positives = 90/216 (41%), Gaps = 38/216 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A++ V++ + + G+++ + G V LP ETL+ + Sbjct: 12 VGPEIIDAVIPVLETLSDLMN---LPLDLRFFEAGDETKRKRG--VALPEETLNGVMNSD 66 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +G R + + LRQ+LDLY+ LRP + Y P P P D+ I REN+ Sbjct: 67 ATL----MVAIGESAREVILPLRQKLDLYVNLRPAKSY---PVPRAIPG-FDLTIVRENT 118 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y W+ + ++ + ++R+ R Y Sbjct: 119 EDLYVMSGWRG------------------------LDTAVDLRIITRRASERICRFGYRY 154 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + V +VHK N++ F++ ++A EE Sbjct: 155 ARERGKSRVYVVHKANVL-GGCMLFREVCSRVAEEE 189 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 147 bits (370), Expect = 4e-34, Method: Composition-based stats. Identities = 43/204 (21%), Positives = 80/204 (39%), Gaps = 29/204 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++V P ++V++AA K + + E + +G+ +P + + +++Y Sbjct: 16 IGLEVLPEGIRVLEAAALK-HGLALEFDTFE-WASCDYYLQHGK--MMPDDWAEQLKQYD 71 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDMV 114 G + P + + R+E D Y+ +RPVR + G P + + D V Sbjct: 72 AIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRKVGDIDFV 131 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + REN+E Y+ + G+ I + G R++ Sbjct: 132 VVRENTEGEYSSLG-------------------GIMFENTENEIVIQESIFTRRGVDRIL 172 Query: 175 RAAIEYAIANDRDSVTLVHKGNIM 198 + A + A +R VT K N M Sbjct: 173 KYAFDLAEKRERKHVTSATKSNGM 196 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 146 bits (369), Expect = 5e-34, Method: Composition-based stats. Identities = 55/219 (25%), Positives = 92/219 (42%), Gaps = 33/219 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGV+V K+ + I + G + G+ +P + +D +++Y Sbjct: 21 IGVEVMSEAEKMFQSL-------NLPIQRDYVDWGIQHYLKTGK--VVPIDYIDQVKQYD 71 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G L P + +RQ+LD ++CLRP +++ G P+P+K E D+++ R Sbjct: 72 AILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCE-IDILVVR 130 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 ENSE Y+ I G+ K P+ I + G +R++R A Sbjct: 131 ENSEGEYSNIG-------------------GIFKSGTPDEFAIESAVHTRRGLERVIRYA 171 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 E A R+ VTL K N MK+ + +A E Sbjct: 172 FE-ASRKRRNHVTLATKSNAMKYGMVLWDSVFEAIAMEY 209 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 146 bits (368), Expect = 6e-34, Method: Composition-based stats. Identities = 52/220 (23%), Positives = 81/220 (36%), Gaps = 37/220 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVT +KV+D+A +I W E + G +P + + + Sbjct: 15 IGVDVTREAVKVMDSAT------GGRIEWTEFDYSCERYAKTG--AMMPPDAPTTLAGFD 66 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 + G + P + L + LR+ + Y+ LRPVR G SP+ E MVI Sbjct: 67 AILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLAGVSDEALSMVI 126 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E Y+ I GV + + G +R++R Sbjct: 127 VRENTEGEYSPIG-------------------GVHNRGNQNEFALQESVFTRIGCERIIR 167 Query: 176 AAIEYAIANDRDSVTLVHKGN----IMKFTEGAFKDWGYQ 211 A E A + V K N M + + F + + Sbjct: 168 YAFELAASAGF-RVCSATKSNGIIHSMPYWDSIFNEIAAE 206 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 146 bits (368), Expect = 6e-34, Method: Composition-based stats. Identities = 46/220 (20%), Positives = 82/220 (37%), Gaps = 27/220 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ +K Y + + +G+ +P LD+++ Y Sbjct: 14 IGPEVMNEALKVLRILKDKDYTFQFHADMF--LWNSEYYLQHGR--MMPENGLDILKNYD 69 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-TDMVIF 116 + G + P + L + +R+ Y+ LRPV+ +G P H E + VI Sbjct: 70 AILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQERPINFVIV 129 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+ G + + + +GT+R+ R Sbjct: 130 RENAEGEYS-------------------NSGGRIYQGTDQEIAVQNTIITRKGTERIARY 170 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A +YA + V K N + + + + +A E Sbjct: 171 AFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEY 210 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 145 bits (366), Expect = 9e-34, Method: Composition-based stats. Identities = 49/230 (21%), Positives = 85/230 (36%), Gaps = 35/230 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++V A L V+ A + G + + G+ V PA T +++ Sbjct: 18 IGIEVMEAALPVIAAL-------NLPFDLVPADIGWQCWRAEGETV--PARTWEIMASCD 68 Query: 61 VAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 105 + G +T+ S + LRQ LDLY +RPV G Sbjct: 69 ATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVTDMTG----- 123 Query: 106 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 V+ REN+E +YAG+++ +++ + + + ++ Sbjct: 124 --ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREGQDDATVTLRLQ 181 Query: 166 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMK----FTEGAFKDWGYQ 211 + G R+ A EYA N VT V K +++ F G F+ + Sbjct: 182 TRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQR 231 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 145 bits (366), Expect = 9e-34, Method: Composition-based stats. Identities = 56/221 (25%), Positives = 88/221 (39%), Gaps = 29/221 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ A + + E G + G+ LP + +R++ Sbjct: 16 IGPEVVAEGLKVLSAVAPR---HGLTLDTTEYELGAQRWHATGE--VLPDAVEEELRQHD 70 Query: 61 VAIKGPL---TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 + G + T P G R L + LR Y+ LRPVR Y G +P+ PE DM++ Sbjct: 71 AILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVAPEDIDMLV 130 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RE +E YAG+ GV + P + G +R+VR Sbjct: 131 VREGTEGPYAGMG-------------------GVLRKGTPHEIATQDSVNTRLGVERVVR 171 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A A +TLVHK N++ + ++ ++ E Sbjct: 172 YAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEY 212 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 145 bits (366), Expect = 1e-33, Method: Composition-based stats. Identities = 58/222 (26%), Positives = 93/222 (41%), Gaps = 36/222 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + A L V ++K ++++ ++ I G + Q+ LP L+ + Sbjct: 48 IGPYIMKAALLVARKLLKK-EIADQRVEFVPI-KGMTIEERARQNKSLPPAVLEACKACD 105 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + +KGP TP G S N LR++L LY +RP+R + + D F Sbjct: 106 ILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE---------KGIDWTFF 156 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN E Y G K I + I K S+ G +RL R Sbjct: 157 RENIEGEYI---------------------WGNKGICVGDDLAIDFKILSKPGAERLFRN 195 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 A EYA ++ + ++T+ K NI+K +G F + + +E G Sbjct: 196 AFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPG 237 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 145 bits (366), Expect = 1e-33, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 84/225 (37%), Gaps = 30/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DVT A +V+ + ++ + G +P + ++ +R + Sbjct: 14 IGQDVTDAAWQVLSTVARHS---GFTLTATPFPWSCAFYKETG--AMMPPDGIETLRRFD 68 Query: 61 VAIKG----PLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + G P P + L + +R+ Y +RP R G P+K E D++ Sbjct: 69 AILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLK-AEGFDILCI 127 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+G + A++V + + G +R++R Sbjct: 128 RENTEGEYSGAGGRVHQGTADEV-------------------AVETSIFTRTGVERILRF 168 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + A R + V K N K++ + + +LA E E+ Sbjct: 169 GFDQARQR-RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEV 212 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 145 bits (365), Expect = 1e-33, Method: Composition-based stats. Identities = 54/216 (25%), Positives = 83/216 (38%), Gaps = 30/216 (13%) Query: 3 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI-REYRV 61 V +++ E+A I E+ G G P + I RE Sbjct: 19 PSVIAEAKLLLELYQERA---GLPIDLWELDLGADRYLRDG--TTFPNQIQIAIQRECSA 73 Query: 62 AIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDMVIF 116 + G L P + R + +R DLY +RPVR P+K + D V+F Sbjct: 74 VLLGALGDPRVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVF 133 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E IY G+ G K P+ I + +G +R++RA Sbjct: 134 RENTEGIYVGMG-------------------GQFKRGTPDEVAINEDVNTRKGVERIIRA 174 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 212 A +YA AN R VT+ K N M+ + +++ Sbjct: 175 AFDYARANGRTRVTMADKSNAMRHAHELWLRVFHEV 210 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 144 bits (363), Expect = 2e-33, Method: Composition-based stats. Identities = 58/218 (26%), Positives = 87/218 (39%), Gaps = 31/218 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ A + G Q G+ LP LD +R + Sbjct: 11 IGPEVVAEGLKVLRAVA-------PDVESTPYDLGASRWQRTGE--LLPDTVLDELRRHD 61 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P G R L + LR ELD ++ LRP R + G SP+ P DM+ R Sbjct: 62 AILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAPGAIDMLCVR 121 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 E +E Y G GV + P + + G +R+VR A Sbjct: 122 EGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAFGVERVVRYA 162 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 E A+A R +TL+HK N++ + +++ E Sbjct: 163 FERALARPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAE 200 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 143 bits (362), Expect = 3e-33, Method: Composition-based stats. Identities = 47/214 (21%), Positives = 80/214 (37%), Gaps = 37/214 (17%) Query: 9 MLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLT 68 +++DA E + I W +++ K+ + E L +R +V IKGP+ Sbjct: 98 GRELMDAVQEVICAVKAPIEW-DVHDEFKAKD----SDDVSPEVLKSLRANKVGIKGPVD 152 Query: 69 TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIE 128 + R +R++ + + + +G SP D+VI R+ E Y+GIE Sbjct: 153 S------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIE 203 Query: 129 WKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDS 188 + IK + G R+ YA+ N R Sbjct: 204 HLVVPGVMQT-----------------------IKVSTTAGAARIAEFVFNYAVKNKRKR 240 Query: 189 VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 +T+ HK NIM+ T+G F + A + L Sbjct: 241 ITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLF 274 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 142 bits (359), Expect = 6e-33, Method: Composition-based stats. Identities = 47/210 (22%), Positives = 78/210 (37%), Gaps = 37/210 (17%) Query: 13 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 72 +DA E + I W +++ K+ + E L +R +V IKGP+ + Sbjct: 1 MDAVQEVICAVKAPIEW-DVHDEFKAKD----SDDVSPEVLKSLRANKVGIKGPVDS--- 52 Query: 73 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 132 R +R++ + + + +G SP D+VI R+ E Y+GIE Sbjct: 53 ---RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVV 106 Query: 133 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 192 + IK + G R+ YA+ N R +T+ Sbjct: 107 PGVMQT-----------------------IKVSTTAGAARIAEFVFNYAVKNKRKRITVA 143 Query: 193 HKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 HK NIM+ T+G F + A + L Sbjct: 144 HKANIMRMTDGNFLEAMRAEADKHVDDVLF 173 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 141 bits (356), Expect = 1e-32, Method: Composition-based stats. Identities = 59/217 (27%), Positives = 88/217 (40%), Gaps = 45/217 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V ++V+ A G + + E G Q G + E L+ IR Sbjct: 12 IGPEVIDGAVRVLKAVT-----GRVRFEYYE--GGVDVFQECGSP--IREEDLEEIRRSD 62 Query: 61 VAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + G TTP G RSL + LR+EL LY LR + P E +VI REN Sbjct: 63 AVLFGATTTPFDLPGYRSLILTLRKELGLYANLRII------PDLRTGRE---IVIVREN 113 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 SE +Y GI + + ++ + EG +R+ R A+E Sbjct: 114 SEGLYFGIGAVVNGR------------------------AVDVRLITREGAERIARFAVE 149 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A A +T VHK N++ + F+ ++A EE Sbjct: 150 QAKARG-SFITFVHKANVLT-GDKFFRRIVREVAGEE 184 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 141 bits (355), Expect = 2e-32, Method: Composition-based stats. Identities = 50/213 (23%), Positives = 83/213 (38%), Gaps = 38/213 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + V+ A E + S+ E G+ + G LP T + + Sbjct: 17 IGQEVIPAAVAVLQAVDEVGF------SFTEKQAGDDTRDQTG--AALPETTYEAAADAD 68 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + + LR+ + ++ +RP R Y G + TD+V REN+ Sbjct: 69 ATLFGA----AGETAADVILPLREAVGSFVNIRPARAYPGVDALQPE---TDLVFLRENT 121 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+G E R E + + +++L A Y Sbjct: 122 EGVYSGHE-----------------------DRLSEDLSTLTRVITTSASEQLAEYACSY 158 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 D VHK N+M+ T+G F+D ++A Sbjct: 159 VTERSIDGFHTVHKANVMQETDGRFRDAVSRVA 191 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 140 bits (354), Expect = 3e-32, Method: Composition-based stats. Identities = 56/213 (26%), Positives = 93/213 (43%), Gaps = 46/213 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR-EY 59 IG +V PA ++++A K + +++ G ++ + G LP +T++++R E Sbjct: 16 IGKEVIPAGRRILEA---LPSYLGLKFEFTDLHAGFETFERTG--AALPDKTVEILRNEC 70 Query: 60 RVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 A+ G +++P G S VALR++LDLY +RPV+ P DMVI R Sbjct: 71 DGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVKTVLSAAKP------IDMVIVR 124 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+ED+Y E D+ D + IK SE + R+ A Sbjct: 125 ENTEDLYVKEETTRDTPDGK--------------------VAEAIKRISERASHRIATMA 164 Query: 178 IEYAIANDR------------DSVTLVHKGNIM 198 + A+ + VT+ HK N++ Sbjct: 165 GDIALRRQKIRAAGAPSIHQSPLVTITHKSNVL 197 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 140 bits (353), Expect = 3e-32, Method: Composition-based stats. Identities = 48/204 (23%), Positives = 84/204 (41%), Gaps = 35/204 (17%) Query: 13 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 72 +++ V+ + I W +++ K G+DV + L+ + ++ IKGP + G Sbjct: 2 IESLVKVFSTVQVPIDW-DVFHEHKINSAEGEDV--SPKLLESLCRNKIGIKGPFES--G 56 Query: 73 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 132 +R LR++ L+ + R +G + D +I R+ E Y+GIE + Sbjct: 57 PCLR----KLRKKFQLFAFVAVCRNLEGQNTRY---GKLDCLIIRDQVEGEYSGIEHRVV 109 Query: 133 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 192 + IK + EG R+ R EYA N+R +T+ Sbjct: 110 PGVMQT-----------------------IKVSTAEGADRMARYVFEYAKKNNRKKITVA 146 Query: 193 HKGNIMKFTEGAFKDWGYQLAREE 216 HK NIM+ T+G F + A + Sbjct: 147 HKANIMRLTDGTFLSPMRREAAKY 170 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 139 bits (351), Expect = 6e-32, Method: Composition-based stats. Identities = 59/226 (26%), Positives = 89/226 (39%), Gaps = 37/226 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A ++V+DA E + R ++EI G + + G A+ L E Sbjct: 14 IGPEIVEATVRVLDALAEL-HPESRGWEYVEIDAGADTYRRTGV-ACAEADVRRLRDEVD 71 Query: 61 VAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 +KGP+ TP G L LR LD Y +RPVR + G PS V+ + D VI Sbjct: 72 ATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRVR-ADRVDYVI 130 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E +YA + + EGT R+ R Sbjct: 131 VRENTEGLYASRGKGVGN----------------------RWAVTDTLLTTREGTLRVAR 168 Query: 176 AAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A A VT V K N+++ + F++ ++A E Sbjct: 169 KAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAE 213 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 136 bits (343), Expect = 5e-31, Method: Composition-based stats. Identities = 53/216 (24%), Positives = 86/216 (39%), Gaps = 48/216 (22%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDV-WLPAETLDLIREY 59 I +VT A+ +V+DA Y ++ + G+++ L E +D IR+ Sbjct: 8 IDSNVTNAVHQVMDAMQAPVY--------------FETYIIKGKNMNHLTWEVVDSIRKN 53 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +V + G + + GG R+ELDL+ L G PS E D+V+ REN Sbjct: 54 KVCLNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPS---RHENVDIVVIREN 103 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E YAG E + E ++ + R+ + A E Sbjct: 104 TEGEYAGREHEVVPGVIESFQVT----------------------MTKFWSDRIAKYAFE 141 Query: 180 YAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAR 214 YA + R VT VH G K + F + ++A+ Sbjct: 142 YAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAK 177 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 136 bits (343), Expect = 5e-31, Method: Composition-based stats. Identities = 48/230 (20%), Positives = 96/230 (41%), Gaps = 38/230 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +K +++ + + + S+ + G K+ + +G +P ET+D + Sbjct: 13 IGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MPKETIDSCLKSD 67 Query: 61 VAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-PSPVKHP--ELT 111 + G + P + LR+E+DLY +RP+ Y G SP+K E Sbjct: 68 AVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSPIKERKLEGV 127 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 + VI+RE + IY G + ++ + SE+ + Sbjct: 128 NFVIYRELTGGIYFGKKGRSKNGK----------------------EAYDYCVYSEKEIE 165 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ + + A + +R +TLV K N++ T +++ ++A + +L Sbjct: 166 RIGEMSFKAARSRNRK-MTLVDKANVL-ETSRLWREVIQKMALDYSDVDL 213 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 135 bits (340), Expect = 1e-30, Method: Composition-based stats. Identities = 46/150 (30%), Positives = 74/150 (49%), Gaps = 12/150 (8%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +++ A+ + +AA + I W E + + GQD + A+ LD +R R Sbjct: 42 VGPEISVAVQNIFNAA-------DVPIVWDEHHIDVDNA-KPGQD-LISADALDSLRRNR 92 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +KGP+ TP+G G RSLN+ LR+ L LY +RP G +P + D+V REN+ Sbjct: 93 FGLKGPMATPIGKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---DDVDVVTVRENT 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVK 150 E Y+G+E E + E + + Sbjct: 150 EGEYSGLEHVVYPGVVESLKVITPERVNAR 179 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 134 bits (338), Expect = 2e-30, Method: Composition-based stats. Identities = 44/225 (19%), Positives = 83/225 (36%), Gaps = 30/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DVT A V++ + A G + G +PA+ ++ ++ + Sbjct: 14 IGRDVTDAAWAVLE---KTAGSGGFSLEATRYPWSCDYYLENGS--MMPADGIETLKSFD 68 Query: 61 VAIKGPLTTPVGG----GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + G + P + L + +R+ Y +RP R G P++ + D++ Sbjct: 69 AILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPLRS-DGFDILCI 127 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+G + I + +G +R++R Sbjct: 128 RENTEGEYSGAGGRIHQG-------------------ADNEVAIETAIFTRKGVERILRF 168 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 E A A R + V K N K++ + + + L+ E E+ Sbjct: 169 GFEQARAR-RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEV 212 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 133 bits (336), Expect = 3e-30, Method: Composition-based stats. Identities = 44/204 (21%), Positives = 72/204 (35%), Gaps = 34/204 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKA--YKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIRE 58 IGV+V P L+ +DA + I W K Q +P + + Sbjct: 51 IGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQ------MMPDDWKTQLSG 104 Query: 59 YRVAIKGPL----TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTD 112 + G + T P + + R+E D Y+ LRP R + G P P+ + D Sbjct: 105 MDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDID 164 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 +I REN+E Y+ + G + + GT+R Sbjct: 165 FMIVRENTEGEYSAVG-------------------GTMFEGTEREFVVQQAVFTRHGTER 205 Query: 173 LVRAAIEYAIANDRDSVTLVHKGN 196 +++ A E A +T+ K N Sbjct: 206 VLKFAFELAQRRA-KRLTVATKSN 228 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 133 bits (335), Expect = 5e-30, Method: Composition-based stats. Identities = 59/221 (26%), Positives = 86/221 (38%), Gaps = 37/221 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V L V+DA + + G+ L LD IR Sbjct: 30 IGPEVIEPALDVLDALGLGTRTDILD------HVNADTYLRTGE--ALTGSDLDRIRSSE 81 Query: 61 VAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDMVI 115 A+ G + P G +R + LR ELDLY+ RP R + SP++ P D VI Sbjct: 82 AALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARRAIDCVI 141 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E +Y+GI G + PE + + + G R++ Sbjct: 142 VRENTEGLYSGIG-------------------GGARTGTPEEIAVDVDLSTRHGVSRVLE 182 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKD-WGYQLARE 215 A A R SV LV K N ++ ++ WG +AR Sbjct: 183 FAFSAA----RRSVCLVDKANAVRNGGQLWQRCWGEAVARH 219 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 133 bits (334), Expect = 5e-30, Method: Composition-based stats. Identities = 47/222 (21%), Positives = 87/222 (39%), Gaps = 33/222 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +++++ E ++ + GE Q G+ LP D Sbjct: 15 IGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGE--YQRSGE--ALPQSAYDACLASD 70 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMV 114 + G + P G + + LR+ L LY +RP+R Y +P+K P D V Sbjct: 71 AVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGEIDFV 130 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE++E ++ G + AD + + ++R+ Sbjct: 131 LVRESTEGLFYGRDAIADLEA---------------------DEATNLLRITRSASERVC 169 Query: 175 RAAIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 R A E A + +VTL+ K N++ + F+ ++A+E Sbjct: 170 RLAFETARRRDGKKTVTLIDKANVLS-SMVYFRHVFDEVAKE 210 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 129 bits (324), Expect = 7e-29, Method: Composition-based stats. Identities = 49/223 (21%), Positives = 83/223 (37%), Gaps = 42/223 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V+ A ++V+ +A I + + G + + G P T R+ Sbjct: 23 IGPEVSAATVRVL----TQALGTSFPIEFRDYDAGAECFRRTG--TAFPEATQVACRQAH 76 Query: 61 VAIKGPLTTP---VGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTD 112 + G P G + ++ +R LDLY +RP+R +G P + K P+ Sbjct: 77 AVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGKGPDDIR 136 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 I REN+E +YA + EG +R Sbjct: 137 FTIVRENTEGLYAARG---------------------GGNIIRGQIATDTLVMTREGVER 175 Query: 173 LVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWG 209 +VR A E A A+ VT+V K N+++ + F++ Sbjct: 176 IVRYAAELARDGQGAPADGVRRVTIVDKANVLR-SYAFFREIA 217 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 128 bits (323), Expect = 9e-29, Method: Composition-based stats. Identities = 46/180 (25%), Positives = 96/180 (53%), Gaps = 19/180 (10%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++T AM+ V++A+E AY G + I W +IY G ++ + YG+ +LP E+++ IR+ Sbjct: 27 GTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGK--YLPRESIEDIRKTVF 84 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 +KGPL++ + G +N+ +++ L+LY ++ + G E ++ IF + + Sbjct: 85 VMKGPLSSNING--HDININIKRILNLYTDVKCITGLPGLS------EGKEIFIFSPSID 136 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 ++Y + DS D++ + ++L++ + I +K S R+++ A + A Sbjct: 137 EVY---HFSYDSEDSDMLRQYLQQSFNIS---IGGDSDIFLKGTSRY---RIIKIASKIA 187 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 127 bits (319), Expect = 2e-28, Method: Composition-based stats. Identities = 50/228 (21%), Positives = 92/228 (40%), Gaps = 38/228 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +KV++ EK K+++ E + G + G LPAETL E Sbjct: 14 IGPEVMAEAMKVLNKVQEKF---GFKLNFNEFFVGGAAIDHCGYP--LPAETLKGCDEAD 68 Query: 61 VAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTP--SPVK---HP 108 + G + P + R + LR+ L+ LRP Y+G P++ Sbjct: 69 AILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLRADIAA 128 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 + DMV+ RE + IY G + ++ + + + Sbjct: 129 KGFDMVVVRELTGGIYFG-------------------QPKGREGEGSQTKAFDTEVYYKY 169 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 +R+ RAA E A+ + VT V K N+++ + +++ ++A++ Sbjct: 170 EIERIARAAFEAAMKRN-KKVTSVDKANVLQ-SSILWRETVTEMAKDY 215 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 123 bits (310), Expect = 3e-27, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 90/233 (38%), Gaps = 42/233 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV++ +K + + + G + +G+ LP ET + E Sbjct: 11 IGPEVVREALKVLEVVEKK---TGKTFEKVFGHIGGDAIDRFGEP--LPEETKKICLEAD 65 Query: 61 VAIKGPLTTP----VGGGIRSLN---VALRQELDLYICLRPVRYYQGT--PSPVKHP--- 108 G + P + R +ALR+ L+LY +RP++ Y+ SP+K Sbjct: 66 AIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLKEKVIG 125 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D+V RE S +Y G + E G + Sbjct: 126 SGVDLVTVRELSYGVYYG-----------------------QPRGLDEEKGFDTMIYDRK 162 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +R+ R A E A N R VT V K N++ ++ ++ ++ARE EL Sbjct: 163 TVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREYPDVEL 213 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 123 bits (309), Expect = 4e-27, Method: Composition-based stats. Identities = 52/232 (22%), Positives = 84/232 (36%), Gaps = 36/232 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++VT A L V + I W + + G +P+ T LI Sbjct: 17 IGIEVTEATLPVFEVLDVPVILNYGDIGW-------EFWKKEG--AAIPSRTWQLIASSD 67 Query: 61 VAIKGPLTTPVGGGIR---------------SLNVALRQELDLYICLRPVRYYQGTPSPV 105 + G +T+ + S + LRQ LDL+ +RP P Sbjct: 68 TVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDDQSKP- 126 Query: 106 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 + I RENSE +Y G ++ K I L E + + ++ Sbjct: 127 -----FNFCIIRENSEGLYCGFDYFPLP----KAIHSLLAESQHWQTIPADEASCALRLQ 177 Query: 166 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF-KDWGYQLAREE 216 S+ G RL A ++A+ VTL K N+++ + G F + A+ Sbjct: 178 SKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRES-GEFTRKIFESTAQRY 228 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 122 bits (306), Expect = 9e-27, Method: Composition-based stats. Identities = 46/175 (26%), Positives = 82/175 (46%), Gaps = 33/175 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ +++K+ DAA + + + G + G+ +P + + + Sbjct: 12 IGYEISESLVKIFDAA-------KVPVEFETENAGSDVYEKTGE--LIPESLYESVERNK 62 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +AIKGP+TTP+G G RS+NV LR++ DLY R R G + + D+ IFREN+ Sbjct: 63 IAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY---DNIDLAIFRENT 119 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 E IY G E + + I +K +++G++ L++ Sbjct: 120 EGIYIGEEKYENEE---------------------KTSAIAVKRITKKGSEELLK 153 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 121 bits (303), Expect = 2e-26, Method: Composition-based stats. Identities = 45/240 (18%), Positives = 77/240 (32%), Gaps = 55/240 (22%) Query: 6 TPAMLKVVDAAVEKAYKGERKISW--MEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAI 63 LKV+ A E I W ++ G + G W P++ + + Sbjct: 1 MREGLKVLHAVSEP-----LGIEWAIEDVPCGGQYYLEQGDLDW-PSDAPQKCDAADLIL 54 Query: 64 KGPLTTPVGGGIR-------------SLNVALRQELDLYICLRPVRYYQGTPSPVKH--- 107 G + P G S + R L+LY +RP++ Y G + Sbjct: 55 LGAVGWPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHK 114 Query: 108 ----PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIK 163 DMVI REN+E +YA K I + Sbjct: 115 QIWEAGKVDMVIIRENTEGLYAPTGGKLAPGGKA-------------------DVAIDTR 155 Query: 164 PCSEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + ++++R A E ++ VT + K N++ F+D +++ E Sbjct: 156 VITRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEY 214 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 117 bits (293), Expect = 3e-25, Method: Composition-based stats. Identities = 49/228 (21%), Positives = 86/228 (37%), Gaps = 42/228 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR-EY 59 IG ++ + ++V+ AA + + ++ + G + + G + A TL+ IR Y Sbjct: 17 IGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTGS--AMSAATLERIRTRY 70 Query: 60 RVAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 +KGP+ P G L LR LD Y +RP+ G +P++ D V Sbjct: 71 HGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRG-TAVDYV 129 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 I REN+E +Y + + + G +R+V Sbjct: 130 IVRENTEGLYLSRGRGVGN----------------------DRACADQLLMTRHGVERVV 167 Query: 175 RAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A E A VT V K N+++ + F++ ++A Sbjct: 168 VHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRY 214 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 117 bits (292), Expect = 4e-25, Method: Composition-based stats. Identities = 50/231 (21%), Positives = 89/231 (38%), Gaps = 36/231 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T + ++V++ EK +S+ G + +G LP +T++ + Sbjct: 13 IGKEITDSAVEVLEKVDEKF---GLGLSYTYKDAGGTAYDKFGTP--LPDDTIEACKASD 67 Query: 61 VAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGTP--SPVKHP--EL 110 + G + V +R + LR+ L LY LRPV+ SP+K + Sbjct: 68 GVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPLKPELVKG 127 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+VI RE IY G + +++ + ++ S Sbjct: 128 VDLVIVRELIGGIYFGDKCESEQHNGA-------------------ERAWDLENYSVPEV 168 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ + A E A R VT V K N++ T ++ ++A EL Sbjct: 169 DRIAKLAFETAKLR-RGKVTSVDKANVL-ATSRLWRRTVAKVAESYPDVEL 217 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 116 bits (290), Expect = 6e-25, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 80/233 (34%), Gaps = 38/233 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V KV++ K + +I+ + G + +G LP T+ E Sbjct: 12 IGPEVMVEAKKVLNTVASKF---DFEITTQDYDIGGAAIDNHGN--ALPDSTMAGCIESD 66 Query: 61 VAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT-- 111 + G + P + R + LR DL+ +RP S Sbjct: 67 AILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLRSDISE 126 Query: 112 ---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D+++ RE + DIY G E ++ E G S Sbjct: 127 QGFDVLVIRELTGDIYFG-------------------EPKGRRGEGEEETGFDSMFYSRR 167 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 KR+ A + A + + VT V K N++ T ++ ++A E EL Sbjct: 168 EVKRISHLAFQAAQKRN-NKVTSVDKANVL-ATSQLWRQVVEEVAVEYPDVEL 218 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 116 bits (290), Expect = 7e-25, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 74/227 (32%), Gaps = 37/227 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + L V++ E+ G + + G Q G E + ++ Sbjct: 17 IGPEIVASSLHVLEVLNERM--GGIGFDFWHLEGGAAHYQKTG--TAFSDENMAACKKAD 72 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMV 114 + G + P G + + LR E+DLY LRP+R Y P + K D+V Sbjct: 73 AVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDKRASQIDLV 132 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE +E I + + S GT R+ Sbjct: 133 LVREQTEGILYSR---------------------CRGTIEDDRVAWETMMISRNGTSRVS 171 Query: 175 RAAIEYAIANDRD-----SVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A A + V V + N + + F+ ++A Sbjct: 172 EFAFRVAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEVAERH 217 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 115 bits (289), Expect = 8e-25, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 87/227 (38%), Gaps = 42/227 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++V+ A EK K+++ G + G P ET + + Sbjct: 13 IGPEISVQGVEVMSAVCEKF---GHKVNYEYAICGADAIDKVGDP--FPEETYRVCKNAD 67 Query: 61 VAIKGPLTTPVGGGIRSLNV-------ALRQELDLYICLRPVRYYQGT--PSPVKHP--E 109 + + P + V A+R++L L+ +RPV+ ++ SP++ E Sbjct: 68 AVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPLRAELVE 127 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D + RE + +Y G +++ + + Sbjct: 128 GADFLCIRELTGGMYFGEKYQDN------------------------DKAYDTNMYTRPE 163 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 +R+++ EYA+ R +T+V K N++ + ++ ++A + Sbjct: 164 IERILKVGFEYAMKR-RKHLTVVDKANVLASSR-LWRQIAQEMAPQY 208 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 113 bits (284), Expect = 4e-24, Method: Composition-based stats. Identities = 49/245 (20%), Positives = 87/245 (35%), Gaps = 47/245 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A ++ E G + +G V P ET + + Sbjct: 25 IGPEITDACRGLI-------ADVFPHWELTETQIGWSQWRAHGNPV--PQETWETLGRSD 75 Query: 61 VAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 105 A+ +T+ G RS + LRQ LDL+ +RPV G + Sbjct: 76 AALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-TLPGAAA-- 132 Query: 106 KHPELTDMVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 159 D I REN+E +Y+ + ADS + + + + + Sbjct: 133 ------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVARAVDKRGEVA 186 Query: 160 IGIKPCSEEGTKRLVRAAIEYAIANDR--------DSVTLVHKGNIMKFTEGAFKDWGYQ 211 + ++ + RL R A + A+A +VT+ K NI++ + + + Sbjct: 187 VSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSARVIRGAVEE 246 Query: 212 LAREE 216 +A E Sbjct: 247 VAEEY 251 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 113 bits (283), Expect = 5e-24, Method: Composition-based stats. Identities = 50/224 (22%), Positives = 85/224 (37%), Gaps = 40/224 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT A LKV+ A E +++ G + +G+ P T + E Sbjct: 11 IGPEVTEAALKVLRALDE---AEGLGLAYEVFPFGGAAIDAFGEP--FPEPTRKGVEEAE 65 Query: 61 VAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTP--SPVKH--PEL 110 + G + P G+ + ++LR+ DL+ LRP + + G SP+K Sbjct: 66 AVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARG 125 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + IY G + E + S+ Sbjct: 126 VDVLIVRELTGGIYFG-----------------------EPRGMSEAEAWNTERYSKPEV 162 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 +R+ R A E A R V V K N+++ E ++ ++ R Sbjct: 163 ERVARVAFEAARKR-RKHVVSVDKANVLEVGE-FWRKTVEEVGR 204 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 113 bits (282), Expect = 6e-24, Method: Composition-based stats. Identities = 48/226 (21%), Positives = 82/226 (36%), Gaps = 35/226 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDV A + V++ A++ + GE + EI G + G D + + Sbjct: 11 IGVDVAEAAIAVLETALK--HTGEPAPRYDEIQAGAGYFKETGLD--IEDGGEERAGLAD 66 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE--LTDMV 114 G + P G S ++ LR LY +RPV+ Y P + P D+V Sbjct: 67 AIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLV 126 Query: 115 IFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 I RE++E + Y+ K + + + + + + T +L Sbjct: 127 ILRESTEGLFYSAAAHK-------------------RSLVVNDDEVQDVLRITRKTTTKL 167 Query: 174 VRAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLARE 215 R A A +T V K N+ + F+ ++ E Sbjct: 168 HRFAFNLARKRRERGHPGRLTCVDKANVFT-SLAFFRQIFDEVKSE 212 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 112 bits (280), Expect = 1e-23, Method: Composition-based stats. Identities = 51/226 (22%), Positives = 86/226 (38%), Gaps = 33/226 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++ V+ A++ GE ++ + G ++ G+ +P ET + I Sbjct: 17 IGPEIVAPTVQAVELALQA--SGEATPEFVPLLLGREAINATGR--IVPEETWETITGLD 72 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 I GP P G + + LR++ DL+ +RPVR G P D+VI Sbjct: 73 GWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP-----DLDVVIV 127 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR-FPEHCGIGIKPCSEEGTKRLVR 175 REN+E +YA S D + + + + +G Sbjct: 128 RENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAAIAAARDGV----- 182 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +T+ HK N++ T G + A EEFG E+ Sbjct: 183 -------------LTVAHKSNVLTETSGRYVAEAKACA-EEFGVEV 214 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 110 bits (275), Expect = 3e-23, Method: Composition-based stats. Identities = 45/227 (19%), Positives = 84/227 (37%), Gaps = 36/227 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V + +V+ VE+ Y + Y G + + GQ LP TL Sbjct: 13 VGPEVMESAKEVLH-MVERLY--GHHFHLQDEYFGGVAIDLTGQP--LPQRTLAACLASD 67 Query: 61 VAIKGPLTTPVGGGIRSL----NVALRQELDLYICLRPVR--YYQGTPSPVKHPELTDMV 114 + G + P + +ALR+ L ++ +RPV SP+K+ + D V Sbjct: 68 AVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNADEIDFV 127 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE + IY + A + + R E+ +R+V Sbjct: 128 VVRELTGGIYFSYPKERTEEVATDTLTYHRHEI-----------------------ERIV 164 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A + A + VT + K N++ + ++ ++A E+ Sbjct: 165 SYAFQLANKR-KKKVTSIDKANVL-ESSKLWRTVTEEVALRYPNVEV 209 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 109 bits (272), Expect = 7e-23, Method: Composition-based stats. Identities = 44/222 (19%), Positives = 87/222 (39%), Gaps = 38/222 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ L +++ K Y +I E G S +G+ L +TL+ + Sbjct: 13 IGPEILNGSLSLLEIISNK-YNFNYQIEHHEF--GGASIDTFGEP--LTEKTLNACKRAD 67 Query: 61 VAIKGPLTTPVGGGIRSL----NVALRQELDLYICLRPVRYYQGTPSPV----KHPELTD 112 + G + P + + LR+ L+L+ +RP +G S + E TD Sbjct: 68 AILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKAERVEGTD 127 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 +VI RE + IY G ++ +A + + + E +R Sbjct: 128 LVIVRELTSGIYFGEPRYFNNHEALDSLTY-----------------------TREEIER 164 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 +V A + A + R +T V K N++ + ++ ++++ Sbjct: 165 IVHVAFKLAASR-RGKLTSVDKENVL-ASSKLWRKVVNEVSQ 204 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 108 bits (270), Expect = 1e-22, Method: Composition-based stats. Identities = 52/225 (23%), Positives = 87/225 (38%), Gaps = 40/225 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ L+++ EK Y E + + G S YG L ETL + Sbjct: 13 IGPEILSGTLELLKLISEK-YHFEYHLE--SHHFGGVSIDYYGTP--LTNETLQSCKNAD 67 Query: 61 VAIKGPL-----TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTP--SPVKHP--ELT 111 + G + T P L + LR+ L+L+ +RP +G SP+K E T Sbjct: 68 AILLGAIGGPKWTDPNNRPEHGL-LKLRKSLNLFANIRPTFVTKGASHLSPLKQDIVEGT 126 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D+VI RE + IY G +A +K+ +E+ + Sbjct: 127 DLVIVRELTSGIYFGEPSYVKKTEALDSLKYSSQEI-----------------------E 163 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 R+VR A A R +T V K N++ + ++ + ++ Sbjct: 164 RIVRIAFNLANRR-RKKLTSVDKENVLS-SSKLWRQIVNDVKKDY 206 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 107 bits (267), Expect = 3e-22, Method: Composition-based stats. Identities = 51/250 (20%), Positives = 89/250 (35%), Gaps = 58/250 (23%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A ++A A ++ W + +G+ +PA+ + Y Sbjct: 18 IGPEVMAATRHALEALPGPALVLT-ELGW----PAHAWHRDHGE--MMPADWRGQLAGYD 70 Query: 61 VAIKGPLTTP-----------VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 + G L P G + + LR+ LDL+ C RP G P P+ P Sbjct: 71 ALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGAPMPLSDPR 130 Query: 110 LT--DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 D+++ RENSE Y ++ G P ++ + Sbjct: 131 ALHTDLLVIRENSEGEYV-------------------DQGGRLAAGTPRETATQLEVFTR 171 Query: 168 EGTKRLVRAAIEYA----------IANDR---------DSVTLVHKGNIMKFTEGAFKDW 208 GT+R++R A E A + R +V +V K N +++ + + Sbjct: 172 AGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEV 231 Query: 209 GYQLAREEFG 218 ++A E G Sbjct: 232 FAEVAAEYPG 241 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 104 bits (260), Expect = 2e-21, Method: Composition-based stats. Identities = 43/233 (18%), Positives = 79/233 (33%), Gaps = 38/233 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + T + K+++ ++ + I E G + G P TL + Sbjct: 15 IGPETTRQVYKILNVIKKQF---QINIVTTEHKIGGDAINSEGTP--FPKSTLKYCEQSN 69 Query: 61 VAIKGPLTTPVGGGIRS-------LNVALRQELDLYICLRPVRYYQGTP--SPVK---HP 108 + G + P ++ +ALR+ +L+ LRP+ SP+ P Sbjct: 70 AILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKELSPLNINMIP 129 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D++ RE + IY G + G E+ Sbjct: 130 NGIDIIFVRELTGGIYFG------------------QPKGRSGTGLNEY-AFDTAVYHRF 170 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +R+ A + A R V+ + K N++ T +++ LA+ EL Sbjct: 171 EIERIANIAFKLAQKR-RKRVSSIDKANVL-HTSMLWREVVSHLAKNYPDVEL 221 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 101 bits (252), Expect = 2e-20, Method: Composition-based stats. Identities = 50/235 (21%), Positives = 82/235 (34%), Gaps = 43/235 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V V+ A + + E+ G + + G V LP ETL + ++ Sbjct: 154 IGPEVISVAKNVLKLAGSL---EGIEFGFQEMPVGGCALDLTG--VPLPEETLLVAKQSD 208 Query: 61 VAIKGPLTTPVGGGIRSLN----------VALRQELDLYICLRPVRYYQGT--PSPVKH- 107 + G + GG N + LR L ++ LRP S +K Sbjct: 209 AVLLGAI----GGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDASTLKKE 264 Query: 108 -PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 166 E D+++ RE + IY G + G K E G + + Sbjct: 265 VAEGVDLMVVRELTGGIYFG------------------KPRGFSKNENGEEIGFNTEVYA 306 Query: 167 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ R A E A R + V K N+++ + ++ +A E EL Sbjct: 307 TYEIDRIARIAFETAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVEL 359 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 101 bits (251), Expect = 2e-20, Method: Composition-based stats. Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 35/231 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V V+ A + + E+ G + + G V LP ET + Sbjct: 57 IGPEVISVAKNVLQKAGSL---EGLEFDFKEMPVGGAALDLVG--VPLPEETFTAAKLSD 111 Query: 61 VAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGT--PSPVKH--PEL 110 + G + +R LR++L ++ LRP S +K E Sbjct: 112 AILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEG 171 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 DM+I RE + IY G E G+ E G+ + + Sbjct: 172 VDMMIVRELTGGIYFG------------------EPRGITINENGEEVGVSTEIYAAHEI 213 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ R A E A R + V K N++ + ++ LA E EL Sbjct: 214 DRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVEL 262 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 99.3 bits (246), Expect = 8e-20, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 76/229 (33%), Gaps = 35/229 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V + +++D G G + V + T+ L + Sbjct: 14 IGTEVMAEVSRLID---WLNKAGIASFETEHGLVGGAAYDA--DKVAITDATMALAQASD 68 Query: 61 VAIKGPLT------TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----EL 110 I G + P + + LR++L L+ LRP Y E Sbjct: 69 AVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEASSLKPEVVEG 128 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + +Y G E + + + I + Sbjct: 129 LDIMIVRELTGGVYFG------------------EPKTITDLGNGQKRAIDTQVYDTYEI 170 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 171 ERIGRVAFDLARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREYKD 217 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 97.4 bits (241), Expect = 3e-19, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 45/128 (35%), Gaps = 26/128 (20%) Query: 82 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 141 L LDLY + ++ + + D+++ EN+E Y+ +E ++ E Sbjct: 2 LHTTLDLYASVIHLKNLPNVET---WHKDVDILVVWENTEGEYSNLEHESVKGVTE---- 54 Query: 142 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 201 +K ++ + R+ A + A V VHK NI K Sbjct: 55 -------------------SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLG 95 Query: 202 EGAFKDWG 209 +G F Sbjct: 96 DGPFLQCC 103 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 96.2 bits (238), Expect = 7e-19, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 70/209 (33%), Gaps = 34/209 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + + KV+ E G + +GQ + ++ Sbjct: 14 IGPEAMAEVRKVI---AFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDADMEKALAAD 68 Query: 61 VAIKGPLTTPVGGGIRSL------NVALRQELDLYICLRPVRYYQGTP-SPVKHPELT-- 111 + G + P + + LR+++ LY LRP Y S PE+ Sbjct: 69 SVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSSSLKPEVIEG 128 Query: 112 -DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + +Y G E + + + GI + Sbjct: 129 LDILILRELTGGVYFG------------------EPKEIIDLGNGQKRGIDTQVYDTYEI 170 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMK 199 +R+ A E A R+ VT + K N+MK Sbjct: 171 ERIADVAFELARTR-RNKVTSMEKRNVMK 198 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 96.2 bits (238), Expect = 7e-19, Method: Composition-based stats. Identities = 39/230 (16%), Positives = 85/230 (36%), Gaps = 39/230 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +KV+ ++ + ++ G + G P ET + Sbjct: 14 IGPEVMKEAVKVLKLIEQR--NEDVNFELNDVLFGAAAYFAMGH--AFPDETKAACDKAD 69 Query: 61 VAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRPVRYYQGTP--SPVKH-- 107 +KG + R + LR+ + + RPV +G SP+K Sbjct: 70 AILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHFSPLKASV 129 Query: 108 -PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 166 E D++I RE +Y G + +AD ++ ++ + E Sbjct: 130 IGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYD------------------- 170 Query: 167 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 E+ +++V+ E ++ + + +HK N++K + + + + ++ Sbjct: 171 EDQIRQIVKVGFEVSMKR-KKVMHNIHKSNVLK-SSVLWNEIVEEESKNY 218 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 95.8 bits (237), Expect = 9e-19, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 84/213 (39%), Gaps = 36/213 (16%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G V A+ K+ AA+ + +S +Y K+ ++ + + LD E + Sbjct: 52 GPVVLAAVRKIFKAALVPVEWDYQTLS---VYRDHKTNRMT-----VNPQLLDSAIETGL 103 Query: 62 AIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + ++P + S ++AL + L+ ++ +R G + ++V RE+ Sbjct: 104 VLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFNSVVG----HEPYGPINLVNIREHV 159 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 Y+ IE + IK S++ + + + A +Y Sbjct: 160 SGEYSEIEHLVSPGVVQ-----------------------SIKTVSKKISVEVAKLAFDY 196 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA 213 A + +T++HK ++M+ ++G F +++ Sbjct: 197 ACKHGHSRITVLHKADVMRLSDGIFLKACREVS 229 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 95.5 bits (236), Expect = 1e-18, Method: Composition-based stats. Identities = 51/224 (22%), Positives = 81/224 (36%), Gaps = 39/224 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + A A + + + E G + + G V ETL E Sbjct: 15 IGPEVVAAARR---VADAAAARFGLTLEYEERRIGAAAIREEGAPV--SKETLRRAGEAD 69 Query: 61 VAIKGPLTTP--VGGGIRSL--NVALRQELDLYICLRPVRYYQGT--PSPVKH--PELTD 112 + G + P GG +R +ALR+EL + LRPV SP++ E D Sbjct: 70 AVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSPLRPGVAEGVD 129 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 ++I RE + Y G + E + + +R Sbjct: 130 LLIVRELTGGAYFG------------------------EKEEGEERASDLSVYTRGEVER 165 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + R A E A R V V K N++ T ++ ++AR+ Sbjct: 166 VARVAFEAARGR-RGRVASVDKANVL-ATSRLWRRVVGEVARDY 207 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 93.9 bits (232), Expect = 4e-18, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 83/227 (36%), Gaps = 37/227 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++T +KV+ A + + K + G + G V LP E L+ ++ Sbjct: 15 VGQEITAEAIKVLKAISDV--RSNVKFDFENHLIGGAAIDATG--VPLPDEALEASKKAD 70 Query: 61 VAIKGPLTTPV--GGGIRSL--NVALRQELDLYICLRPV-----RYYQGTPSPVKHPELT 111 + G + P G +R + +R+EL LY LRP +P + + T Sbjct: 71 AVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFAKGT 130 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D V+ RE IY G + D + + + + Sbjct: 131 DFVVVRELVGGIYFGKRKEDDG----------------------DGVAWDSEQYTVPEVQ 168 Query: 172 RLVRAAIEYAIANDRDS-VTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R+ R A A+ ++ + + K N++ + ++ + + EF Sbjct: 169 RITRMAAFMALQHEPPLPIWSLDKANVLASSR-LWRKTVEETIKNEF 214 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 92.4 bits (228), Expect = 1e-17, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 78/230 (33%), Gaps = 40/230 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +V++ + E K+ + G S +G+ L A TL+ + Sbjct: 16 IGPEVVAEATRVLEVVSASSSDVEIKLETHDF--GGCSIDKHGEP--LTAATLEACKLAD 71 Query: 61 VAIKGPLTTPVGGGIRSL-----NVALRQELDLYICLRPVR--------YYQGTPSPVKH 107 + G + P G + +ALR+ L LY +RP Y PS + Sbjct: 72 AILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYSPLKPSVARG 131 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 D+++ RE Y G E R E S Sbjct: 132 ---VDIIVIRELIGGAYFG-------------------ERKELGARAQEDAAWDTMIYSV 169 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 +R+ R+ + A + V + K N++ + ++ + + EF Sbjct: 170 PEVQRITRSRRQVASPDPPLPVHSIDKANVLASSR-LWRKVATETIQNEF 218 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 91.2 bits (225), Expect = 2e-17, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 76/233 (32%), Gaps = 45/233 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ +KV+ + ++ + G S +G V + LD + Sbjct: 15 IGPEIMAEAIKVL--TTIETHRPNLHFNLTTDLVGGTSIDTHG--VPITQSVLDAAKASD 70 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYY-QGT--PSPVKHP--ELT 111 + G + P G+ S + LRQ LD + LRP + SP++ + T Sbjct: 71 AVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASPIREHVVKGT 130 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 ++ REN Y G + + E + + + Sbjct: 131 RFIVVRENCGGAYFG------------------------EKKEEEDVASDLWVYTRPEIE 166 Query: 172 RLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 RL R + A R +V K N++ ++ + +EF Sbjct: 167 RLARVSAAVARIMGRSEDDNQAATVWSADKANVLASGR-LWRRITSDIFAKEF 218 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 90.8 bits (224), Expect = 3e-17, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 74/205 (36%), Gaps = 39/205 (19%) Query: 1 IGVDVTPAMLKVVD-AAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREY 59 IG +V A LK++ A + + + W G + + G + P T +L Sbjct: 19 IGPEVVEASLKILQHVAKIQGFTLQVDYGW----LGATAFEQLGS--YFPQATTELCDGA 72 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK-HPELT---DMVI 115 + G ++ + + LR+ D + LRP+R PE D++I Sbjct: 73 DGIVFGAVS-------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLRPEKIQGLDILI 125 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RE IY G ++ R G +R+ + +R+ R Sbjct: 126 VRELVSGIYFGPSGRSSDE---------RGNYGYHTMRYYDEE-----------IRRIAR 165 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKF 200 A+E A R +T+ HK N + Sbjct: 166 KALEQAQYR-RGLLTVAHKENALPH 189 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 88.1 bits (217), Expect = 2e-16, Method: Composition-based stats. Identities = 36/229 (15%), Positives = 71/229 (31%), Gaps = 35/229 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + + K++ + E G + +G + + Sbjct: 14 IGPEAMGEVRKII---AYMNEAMDAGFVTDEGLVGGCAYDAHG--AAISEADMQKALAAD 68 Query: 61 VAIKGPLTTPVGGGIRSL------NVALRQELDLYICLRPVRYYQGTPSPVKHP----EL 110 + G + P + + LR++L L+ LRP Y S E Sbjct: 69 AVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSLKPELVEG 128 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + +Y G E + + + GI + Sbjct: 129 LDILIIRELTGGVYFG------------------EPKEIIDLGNGQKRGIDTQVYDTYEI 170 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 +R+ A E A + V + K N+MK + + + + ++ Sbjct: 171 ERIAGVAFEMARTRQ-NRVCSMEKRNVMK-SGVLWNQVVTETHKAKYSD 217 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 87.4 bits (215), Expect = 4e-16, Method: Composition-based stats. Identities = 43/219 (19%), Positives = 81/219 (36%), Gaps = 31/219 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ P V A I+++ + G + + + L+ ++ YR Sbjct: 12 IGREIMP--------GVAAAISSISDINFVTFDISSERYIKTG--IIIKDDELEELKNYR 61 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P G + + + LR+EL+LY+ +RPVR + + + I R Sbjct: 62 AILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD---------DKIKITILR 112 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN++D Y I + V E G + + S K+ A Sbjct: 113 ENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSC----DEVYYTMGMLSYRYLKKFFNKA 168 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 + +VT+ K N +K ++ + A E+ Sbjct: 169 FSICDS----TVTVTDKANAVKMYN-LWRSTAMEAAIEK 202 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 86.2 bits (212), Expect = 7e-16, Method: Composition-based stats. Identities = 40/225 (17%), Positives = 78/225 (34%), Gaps = 31/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD--VWLPAETLDLIRE 58 IGV+V + +++D K + + E G + V+G L Sbjct: 14 IGVEVMAQVRRIIDWMGRKR---KIEFEITEGLLGGAAYDVHGTPYPAETLEAALAADAV 70 Query: 59 YRVAIKGPL--TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT----D 112 A+ GP P + +R+++ L+ LRP + D Sbjct: 71 LLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADASTLKAEVVSGLD 130 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 ++I RE + +Y G + G+ + G + +R Sbjct: 131 IMILRELTGGLYFG------------------QPRGIDTLPDGTRKGYNTLVYTTPEIQR 172 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 + R A + A + + V K N+++ T +++ +L +EEF Sbjct: 173 IGRVAFDLARKRN-KKLCSVDKANVLECT-VLWREEMIKLQKEEF 215 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 86.2 bits (212), Expect = 8e-16, Method: Composition-based stats. Identities = 28/123 (22%), Positives = 45/123 (36%), Gaps = 24/123 (19%) Query: 94 PVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIR 153 P R + G SP+ D VI RENSE YAG G Sbjct: 95 PTRVFHGIQSPL----HLDWVIVRENSEGEYAGHG-------------------GRSYAG 131 Query: 154 FPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDW-GYQL 212 P I + G +R+++ A E A + + +T+ K N + + + ++ Sbjct: 132 KPWEVATDISIFTRHGVERIMKFAFEAARSRAKKHITVATKSNAQRNGLVVWDEIAAAEV 191 Query: 213 ARE 215 A + Sbjct: 192 AAQ 194 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 85.8 bits (211), Expect = 9e-16, Method: Composition-based stats. Identities = 46/239 (19%), Positives = 76/239 (31%), Gaps = 60/239 (25%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ LK++ E+ + +IS+ G S G + E L+ Sbjct: 15 IGPEIIAEALKILAVLEEELPNFKVQISYG--LIGGASLDKTGS--AITDEVLETAVASD 70 Query: 61 VAIKGPLTTPVGGGIRSL------NVALRQELDLYICLRPVRYYQG---TPSPVKHPEL- 110 + G + P + + LRQ LD + +RP R+Y SP+K PE+ Sbjct: 71 AVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLNQSPLK-PEIA 129 Query: 111 --TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D V+ REN Y G + + + + Sbjct: 130 AGVDFVLVRENCGGAYFGTKTEFEDE-------------------------------ART 158 Query: 169 GTKRLVRAAIEYAIANDRDSVT---------LVHKGNIMKFTEGAFKDWG-YQLAREEF 217 +R R + A R T K N++ G F + + EF Sbjct: 159 EVERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVL--ASGRFWRTVTHDIFEREF 215 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 85.1 bits (209), Expect = 2e-15, Method: Composition-based stats. Identities = 47/229 (20%), Positives = 79/229 (34%), Gaps = 35/229 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V + KV+ + E G S +G + E E Sbjct: 17 IGPEVIQEVKKVI---LWLNSNKSLDFEIDEDLAGGCSYDKHGTP--ITDEVFYKALESE 71 Query: 61 VAIKGPLTTPVGGGIRSLNVALR------QELDLYICLRPVRYYQG-TPSPVKHPELT-- 111 + G + P + R +EL L+ LRP ++ + PE+ Sbjct: 72 FVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDASTLKPEIVSG 131 Query: 112 -DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + IY G E G+K I E GI + Sbjct: 132 LDIMIVRELTGGIYFG------------------EPRGIKPIENGERKGINTHSYTTSEI 173 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 R+ + A + A + VT K N+M+ + +K+ +L +E+ Sbjct: 174 VRVAKVAFDLARKRS-NRVTSCEKSNVMEAGQ-LWKEEVQELHDKEYKD 220 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 83.9 bits (206), Expect = 3e-15, Method: Composition-based stats. Identities = 40/214 (18%), Positives = 74/214 (34%), Gaps = 21/214 (9%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ P + +V + IS E Y + + + +D ++ Y Sbjct: 12 IGKEIIPQVCDLVTSIDPSVNFTFYNIS-SERYIN--------KGITIKDSEIDELKSYN 62 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 G + G + + + LR+ELDLY+ +RP + M I R Sbjct: 63 SIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITG-----NNIHMTILR 117 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN ED Y+ I + + + + S + KR A Sbjct: 118 ENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNLKRFFNMA 177 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQ 211 + A D ++VT+ K N + +++ + Sbjct: 178 YKIA---DTETVTITDKANAVDM-YSLWREIAIE 207 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 83.5 bits (205), Expect = 5e-15, Method: Composition-based stats. Identities = 45/226 (19%), Positives = 76/226 (33%), Gaps = 43/226 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 I +++ A+ V DA +I ++ + ++S + G ++ E +R Y Sbjct: 19 IARELSQAVHTVADAL-------PFEIEFIPVDLSDESREAKGDAIY--DEAEAAMRRYG 69 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 ++K P T S N LR+ + + RPV G + E + I R + Sbjct: 70 TSLKYPTAT----TKESPNRVLRERCNFAVIHRPVATIPGIQTHYN--ERIHLDIVRIAT 123 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 Y R + I+ + R A Sbjct: 124 GGTYED-----------------------AGRRINRDTAVSIRAIERRPSVLASRFAFRL 160 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE----EFGGELI 222 A D +V K I K T+G F++ +AR+ EF EL Sbjct: 161 AQLRD-SNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELF 205 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 80.0 bits (196), Expect = 5e-14, Method: Composition-based stats. Identities = 36/209 (17%), Positives = 65/209 (31%), Gaps = 35/209 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V + +V+D G + G + G L +T+ L Sbjct: 15 IGPEVMAQVRRVMD---WLNQTGRTAFEVEDALVGGAAYDAQGTP--LHDDTVALALAAD 69 Query: 61 -------VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----E 109 K + P + LR++L+L+ LRP + Sbjct: 70 AVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAEASTLKTELVS 129 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D++I RE + +Y G + G+ + E G+ + Sbjct: 130 GLDVMIVRELTGGVYFG------------------QPRGISALPNGERRGVNTQVYDTHE 171 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIM 198 R+ + A + A + V K N+M Sbjct: 172 IVRVAKVAFDLAGKRG-KRLCSVEKANVM 199 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 79.7 bits (195), Expect = 6e-14, Method: Composition-based stats. Identities = 43/228 (18%), Positives = 74/228 (32%), Gaps = 55/228 (24%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +L + D K+ E G + D + TL E Sbjct: 23 IGPEVMAEVLPLFDVIQSHF---GIKVETFERLIGGSCLDQH--DCPIQESTLQEASECH 77 Query: 61 VAIKGPLTTP---VGGGIRSL---NVALRQELDLYICLRPVRYYQGTP---SPVKHP--E 109 + G + P VG R + +R+ L+LY +RP + S +K Sbjct: 78 AVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLELSSLKEHVVR 137 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 +++ REN+ IY G + + D Sbjct: 138 GVNIITLRENAGGIYFGRKQEPDPLAH--------------------------------- 164 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 +AA+ A ++ + V K N+M T ++ + R+EF Sbjct: 165 -----KAALSLASSHGPLPIISVDKANVM-ATSRLWRQVVTETIRDEF 206 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 78.9 bits (193), Expect = 1e-13, Method: Composition-based stats. Identities = 41/207 (19%), Positives = 75/207 (36%), Gaps = 30/207 (14%) Query: 5 VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIK 64 V PA L+++++A A I G+ G P + Sbjct: 22 VLPAALELLESAGLTANW--------RIVAGQAPD---GDGGRKPE----------AGLL 60 Query: 65 GPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 124 P P G L A R+ + V+ ++++FR + Sbjct: 61 PPFAEP-GASAYGLARAARRAWG-----GTFSVIERRGPLVRSDGTVNVLLFRYELDMSD 114 Query: 125 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAN 184 G+E++++S + ++K E + PE +GI+ + + VR A+ Sbjct: 115 TGMEFESNSGEQLALVKTAAE---LGPREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRL 171 Query: 185 DRDSVTLVHKGNIMKFTEGAFKDWGYQ 211 D D + + HKGN +K T+G F + Sbjct: 172 DVDDLVVAHKGNSIKHTDGLFALTAAE 198 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 78.5 bits (192), Expect = 1e-13, Method: Composition-based stats. Identities = 45/227 (19%), Positives = 76/227 (33%), Gaps = 37/227 (16%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G +V +KV+ A +E K + G S + L E L+ + Sbjct: 15 GPEVVLEAIKVLKA-IETNSPSAGKFNLQNHLLGGASIDKHNDP--LTDEALNAAKAADA 71 Query: 62 AIKGPLTTPVGGGIRSL-----NVALRQELDLYICLRPV-----RYYQGTPSPVKHPELT 111 + G + P G ++ + LR+EL Y LRP +P + T Sbjct: 72 VLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGT 131 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D ++ RE + IY G + D + +P S Sbjct: 132 DFIVVRELTGGIYFGDRTEDDGS----------------------GYACDTEPYSRAEIV 169 Query: 172 RLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R+ R A A+ N V + K N++ T ++ + +EF Sbjct: 170 RIARLAGFLALAKNPPAKVWSLDKANVL-ATSRLWRKTVTDVISKEF 215 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 75.8 bits (185), Expect = 9e-13, Method: Composition-based stats. Identities = 39/207 (18%), Positives = 83/207 (40%), Gaps = 45/207 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++K+V + + Y KI+ + Y G S + + + + +I+ Sbjct: 12 IGPEIIKQVIKIVKSCIYTGY----KINIIYNYIGGISIDKF--NTPITNNLISIIKYID 65 Query: 61 VAIKGPLTTPVGGGIR---SL------NVALRQELDLYICLRPVRYYQGTPSPVKHPELT 111 G + GG + S+ + LR++ + + +RP++ P K+ Sbjct: 66 TIFLGCV-----GGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFKN---I 111 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D++I RE + IY G ++++I + P K +E+ Sbjct: 112 DIIIVRELNGGIYYG----KPKGFSKQIIN-----------QIPTWYAYNTKIYNEQEII 156 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIM 198 RL R + A+ N + + + K N++ Sbjct: 157 RLARISFNLAL-NRKKKLCSIDKSNVL 182 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 73.5 bits (179), Expect = 5e-12, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 62/168 (36%), Gaps = 28/168 (16%) Query: 50 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 E + + A+ + + ++ + +LDLY+ + +R + G Sbjct: 107 EEYFNSVLRNHAAV--HVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKCRFP--- 161 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D+ + +N+ Y+ +E+ E ++ + E Sbjct: 162 DVDIQVIAQNNIGNYSELEYAPVKGVVE-----------------------ALRVVTHEN 198 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 + +R A E AI R VTL+HK N T+GA + ++ E++ Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAEDY 246 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 72.0 bits (175), Expect = 1e-11, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 74/227 (32%), Gaps = 37/227 (16%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G +V +KV+ A + K + E G S +V+ + A + + Sbjct: 15 GPEVVAEAVKVLRAIETHSPSVG-KFNLQEHLLGGASIKVHNDPLTAKALAAAKAADAIL 73 Query: 62 AIKGPLTTPVGGGIRSL-----NVALRQELDLYICLRPV-----RYYQGTPSPVKHPELT 111 G + P G + + LR+EL Y LRP +P T Sbjct: 74 L--GAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDSSPLKADVCRGT 131 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D ++ RE + IY G + D + + S + Sbjct: 132 DFIVVRELTGGIYFGARTEDDGS----------------------GFAMDTDAYSRAEIE 169 Query: 172 RLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R+ R A A+ + V + K N++ T ++ ++ EF Sbjct: 170 RIARLAGFLALGTSPPSKVWSLDKANVL-ATSRLWRKVVTEVFANEF 215 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 70.4 bits (171), Expect = 4e-11, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 63/167 (37%), Gaps = 28/167 (16%) Query: 50 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 + + + R A+ + V + ++ L +LDLY+ VR + G Sbjct: 98 DDFYNSVLRNRSAV--HVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRFP--- 152 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 ++ I +N+ +Y+ +E+ E I ++EG Sbjct: 153 DVNIRIIAQNNMGVYSDLEYSPVKGVVE-----------------------AISVSTQEG 189 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 ++ +R A A+ +R VTL+HK T+GA ++ ++ Sbjct: 190 NEKYLRKAFATAVKANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDY 236 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 70.0 bits (170), Expect = 6e-11, Method: Composition-based stats. Identities = 29/163 (17%), Positives = 56/163 (34%), Gaps = 17/163 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + +++ E + + ++ ST + IR Sbjct: 61 IGPE-------LLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDISN-----AIMAIRRNG 108 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + T + +S N LR LDLY + + G + + D++I E Sbjct: 109 VALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQT---RHKNIDIIIILE 165 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 161 SE E + + ++ L + + ++ I Sbjct: 166 KSEFSALLAENEKIKVELLQLRIQLADVINKRRADIILDLNIE 208 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 67.7 bits (164), Expect = 3e-10, Method: Composition-based stats. Identities = 36/227 (15%), Positives = 74/227 (32%), Gaps = 38/227 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++T + + A E R + E G + LP E+L E Sbjct: 24 VGPEITREAVLTLKRAGEV---YGRSFQFTEAIAGTAALDR--GQCPLPRESLKTCLEAD 78 Query: 61 VAIKGPLTTPVGGGIR------SLNVALRQELDLYICLRPVRYYQGTP--SPVK---HPE 109 + G L G++ S+ LR L L +RP + + P+K + Sbjct: 79 SILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELCPLKEEIRKK 138 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D++I R+ + ++ ++ + + + + Sbjct: 139 GMDILIIRDIAGGMFTTEGKSSNLCNVRAAWDTESYDETLIRDS---------------- 182 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 R A + A + R VT + K I+ + ++ + R+ Sbjct: 183 ----ARLAFQLAASRKRK-VTSLDKA-ILLSSSVLWRQILEETHRDY 223 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 65.0 bits (157), Expect = 2e-09, Method: Composition-based stats. Identities = 41/232 (17%), Positives = 74/232 (31%), Gaps = 50/232 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL-DLIREY 59 +G DV P K + A E E + E G + G+ + + L + I + Sbjct: 14 VGKDVIPLGAKAMQKAQEILGGFELDCRYYE--AGVEYAVKTGK---MCEDNLGEDIAKA 68 Query: 60 RVAIKGPLT--------TPVGGGIRSLNVA--LRQELDLYICLRPVRYYQGTPSPVKHPE 109 + G + G + V LR + I LRP+R +G P+++ E Sbjct: 69 DAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKGIDCPLRNRE 128 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D+++ R+ +E Y E + Sbjct: 129 EIDVLLVRQLAEGFYIRPGH-----------------------MIGEDAAYDTIVVTRNV 165 Query: 170 TKRLVRAAIEYAIAN------DRDSVTLVHK-GNIMKFTEGAF-KDWGYQLA 213 T++ A + VTL +K GN+ T F + +++ Sbjct: 166 TEKFADTCFRLARGRHGRRQDGKKMVTLGNKHGNV---TCFDFYRKIFTEVS 214 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 64.6 bits (156), Expect = 3e-09, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 82/225 (36%), Gaps = 32/225 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V L ++ E G+R G ++ ++ G+ L E D + Sbjct: 38 VGPEVIDVALSLLRLLGEAT--GQRFEVRTGGPIGRQAERLTGRG--LTPEVRDFCAQV- 92 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGT-PSPVKHPEL---TDMVIF 116 A G + GGG LR+ DLY L P+R++ + V PE D++I Sbjct: 93 FAQGGAVLCGPGGGR--FVYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAARSADVLIV 150 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+ +Y G EW ++ A + + + +R++R Sbjct: 151 RENASGLYCG-EWGSEGEGAARSAYQVCRYRADE-------------------VERILRT 190 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A+ A R + +V K + + D +A E Sbjct: 191 ALRLAGQR-RGDLVVVTKPGGVPAISALWHDALTAVAGEHGAVRC 234 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 62.3 bits (150), Expect = 1e-08, Method: Composition-based stats. Identities = 37/176 (21%), Positives = 62/176 (35%), Gaps = 30/176 (17%) Query: 49 PAETLDLIREYRVAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQG--TPSPV 105 P+ TL R+ + P G + LRQEL+ + +RPVR+ Sbjct: 65 PSTTLGACRQSDAVLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 106 KHPELT---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGI 162 PE+ D+ FR+ + +Y G +A + Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAG----------------------DDGEAYDT 162 Query: 163 KPCSEEGTKRLVRAAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 P S + +R+ R A YA+ + V + K N+M T ++ + EF Sbjct: 163 TPYSRQTIERIARLAGTYAMQFSPPKPVHSIDKHNVM-ATSRLWRSVVAHVFENEF 217 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 60.8 bits (146), Expect = 4e-08, Method: Composition-based stats. Identities = 24/109 (22%), Positives = 39/109 (35%), Gaps = 19/109 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V V+ A + + E+ G + + G V LP ETL + ++ Sbjct: 53 IGPEVISVAKNVLKLAGSL---EGIEFGFQEMPVGGCALDLTG--VPLPEETLLVAKQSD 107 Query: 61 VAIKGPLTTPVGGGIRSLN----------VALRQELDLYICLRPVRYYQ 99 + G + GG N + LR L ++ LRP Sbjct: 108 AVLLGAI----GGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 57.3 bits (137), Expect = 4e-07, Method: Composition-based stats. Identities = 19/102 (18%), Positives = 36/102 (35%), Gaps = 10/102 (9%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ LK + VE+ + ++ + S + + + LD Sbjct: 15 IGPEIIAEALKPLTVLVEERPDFKVQVRYG--LLAGASLDKTNEP--ITDKVLDAALATD 70 Query: 61 VAIKGPLTTPVGGGIRSL------NVALRQELDLYICLRPVR 96 + G + P + + LRQ LD + +RP R Sbjct: 71 AVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCR 112 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 55.4 bits (132), Expect = 1e-06, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 54/183 (29%), Gaps = 28/183 (15%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ ++V+D + ++ + V ++ +R Sbjct: 16 GQELLDQAVRVLD-----PEVTGLPLELERFDLSLENRRATQNGVV--SDAAAAMRTCGF 68 Query: 62 AIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 IK TP G + S N LR+E+D + +R R G I R Sbjct: 69 GIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIAGVHYPIS--IVRMAI 126 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED Y +W+ A A + + + + + A Sbjct: 127 EDAYGAKQWREGDAGA------------------ADEVAYRTEHVTRSTCRAVSEYAFRT 168 Query: 181 AIA 183 A A Sbjct: 169 ARA 171 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 54.2 bits (129), Expect = 3e-06, Method: Composition-based stats. Identities = 39/221 (17%), Positives = 68/221 (30%), Gaps = 43/221 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V +++ E+ + E W G ++ G LPA TL Sbjct: 12 VGEEVLDGPTRLLRLLAERG-EVEVTGPW---PVGARAAAETGD--VLPAGTLAACDAAD 65 Query: 61 VAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 + G + P G R LR+ DL I +R + + G ++ Sbjct: 66 AILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGR----------ELT 115 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + R Y G + + D + LR + E +V Sbjct: 116 VVRNLIGGSYGGADDRVLREDGSEAADVLR--------------------LTRERVAEVV 155 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A + + V K N + T ++ +ARE Sbjct: 156 HTACDVLGRRGGGRLVSVDKAN-LYATGRLWRQVAGDVARE 195 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 53.9 bits (128), Expect = 4e-06, Method: Composition-based stats. Identities = 40/230 (17%), Positives = 76/230 (33%), Gaps = 58/230 (25%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ L+V+ +V + + + +++ ++ + V E R+ + Sbjct: 17 GEELLIQALRVLQPSVIR-----QPLQFLDYDLSLENRRATDNKVV--WEAAQAARDSGL 69 Query: 62 AIKGPLTTP-VGGGIRSLNVALRQELDLYICLRP------VRYYQGTPSPVKHPELTDMV 114 ++K TP + G + S N LR+ L+ + LR +R G SP + Sbjct: 70 SLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGVYSP--------IA 121 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 I R +D Y EW+ + + + S + + Sbjct: 122 IVRMAVDDAYGSKEWRETTENG-------------------DEIAYRTSKISRSTCRAVA 162 Query: 175 RAAIEYAIANDRDSVTLVHKGNIM---KFT-----EGAFKDWGYQLAREE 216 +YA K + KFT EG FK+ A+ Sbjct: 163 EFTFQYAKR---------TKAKVFGGPKFTVSATYEGMFKEELDAAAKRY 203 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 52.7 bits (125), Expect = 9e-06, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 39/87 (44%), Gaps = 5/87 (5%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V ++ V+ + E ++ + E+ G + G+ ++PA+ L ++ + Sbjct: 19 IGPEVVNVIIDVLKSLQEIL--STYRLEFTELDWGTARYKRTGK--YMPADGLSTLKTFH 74 Query: 61 VAIKGPLTTPVGG-GIRSLNVALRQEL 86 I G + P IR L+ +R+ Sbjct: 75 AGIFGAVGAPGMKFCIRRLDFGVRRTF 101 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 51.9 bits (123), Expect = 1e-05, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 41/108 (37%), Gaps = 15/108 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ KV+D + K + I G S G V L E + + Sbjct: 13 IGPEIVAEAKKVLD---KIGTKYGHSFLYEAILMGGCSIDATG--VPLTDEAIAAAKASD 67 Query: 61 VAIKGPL-----TTP---VGGGIRSL--NVALRQELDLYICLRPVRYY 98 + G + T+P + +R + LR+ L+L+ LRP Y Sbjct: 68 AVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 51.5 bits (122), Expect = 2e-05, Method: Composition-based stats. Identities = 12/28 (42%), Positives = 17/28 (60%) Query: 188 SVTLVHKGNIMKFTEGAFKDWGYQLARE 215 VT +HK NIMK +G F +LA++ Sbjct: 79 KVTCIHKANIMKLADGLFHGTFNRLAKD 106 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 49.6 bits (117), Expect = 7e-05, Method: Composition-based stats. Identities = 23/143 (16%), Positives = 46/143 (32%), Gaps = 28/143 (19%) Query: 50 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 E + R A+ + + + + +LDLY+ R + G Sbjct: 104 DEYFHSVLRNRTAV--HVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKCRFPG-- 159 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D+ + +N+ I+ +E+ E + S++G Sbjct: 160 -VDIQLIGQNNMGIFNELEYSPVEGVVE-----------------------ALSVVSQKG 195 Query: 170 TKRLVRAAIEYAIANDRDSVTLV 192 + +R A + A R VTL+ Sbjct: 196 NDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 48.8 bits (115), Expect = 1e-04, Method: Composition-based stats. Identities = 40/229 (17%), Positives = 76/229 (33%), Gaps = 22/229 (9%) Query: 7 PAMLKVVDAAV-EKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +V+ A + EK I M + V + + I+ + V +K Sbjct: 194 DEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTI--DAALAIKRHGVGVKC 251 Query: 66 PLTTPV---------GGGIRSLNVALRQELDLYICLRPV--RYYQGTPSPVKHPELTDMV 114 TP +S N +R LD I P+ + P ++ Sbjct: 252 ATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPILMKNVPRLVPSWTKP----II 307 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP---CSEEGTK 171 I R D Y +++ D + ++ + E G G+ ++ K Sbjct: 308 IGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKGGGVALGMYNTDASIK 367 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 + +YA+ + L K ++K +G FKD + +E+ + Sbjct: 368 GFAHSCFQYALDQKMP-LYLSTKNTVLKKYDGRFKDIFQTIYEKEYKQK 415 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 47.7 bits (112), Expect = 3e-04, Method: Composition-based stats. Identities = 32/230 (13%), Positives = 82/230 (35%), Gaps = 23/230 (10%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +++ + EK ++ G ++ V + + I+++ V +K Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVT--KDAAEAIKKHNVGVKC 73 Query: 66 PLTTPVGGGI---------RSLNVALRQELD--LYICLRPVRYYQGTPSPVKHPELTDMV 114 TP + +S N +R L ++ + S P ++ Sbjct: 74 ATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP----II 129 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLR---EEMGVKKIRFPEHCGIGIKPCSEEGT- 170 I R D Y ++ ++ +++ F E G+ + +++ + Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 + ++ + A++ + L K I+K +G FKD ++ +++ + Sbjct: 190 EDFAHSSFQMALSKGWP-LYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQ 238 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 47.3 bits (111), Expect = 3e-04, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 34/70 (48%), Gaps = 9/70 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ K+ +AA I W + + +P++ ++L+R + Sbjct: 36 IGPEISSSVQKIFEAANA-------PIEWDPVDV--TPVKGDDGIFRIPSKCIELMRINK 86 Query: 61 VAIKGPLTTP 70 + +KGPL TP Sbjct: 87 IGLKGPLATP 96 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 46.5 bits (109), Expect = 6e-04, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 36/92 (39%), Gaps = 14/92 (15%) Query: 3 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVA 62 ++ ++ V+ A I + I ++V + + I R+ Sbjct: 77 PELMNSVQTVLKAIGA-------PIDFETIL----FSEVQHSSSAKVEDVIKSINRNRIC 125 Query: 63 IKGPLTTP---VGGGIRSLNVALRQELDLYIC 91 + G L +P G +++L++ LR+ LDL Sbjct: 126 LMGALMSPDVSYSGELQNLHMKLRKGLDLIAN 157 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 45.4 bits (106), Expect = 0.001, Method: Composition-based stats. Identities = 33/208 (15%), Positives = 66/208 (31%), Gaps = 29/208 (13%) Query: 31 EIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVA 81 G + V + E + I++Y V +K TP + S N Sbjct: 97 HRPQGIEYRDQTDDKVTV--EAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGT 154 Query: 82 LRQELDLYICLRPV------RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSAD 135 +R L + P+ R G P ++I R D Y + Sbjct: 155 IRNILGGTVFREPIVIPAIPRLVPGWTKP--------IIIGRHAFGDQYRATDRVIPGPG 206 Query: 136 AEKVIKFLREEMGVKKIRFPEHCGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLV 192 +++ + G G+ +++ + ++ + A+ + + Sbjct: 207 KLELVYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLP-LYMS 265 Query: 193 HKGNIMKFTEGAFKDWGYQLAREEFGGE 220 K I+K +G FKD ++ E+ E Sbjct: 266 TKNTILKRYDGRFKDIFQEIYEAEYKKE 293 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 44.2 bits (103), Expect = 0.003, Method: Composition-based stats. Identities = 37/184 (20%), Positives = 67/184 (36%), Gaps = 22/184 (11%) Query: 52 TLDLI---REYRVAIKGPLTTPVGGGI---------RSLNVALRQELDLYICLRP--VRY 97 T+D ++Y VA+K TP + +S N +R L + P + Sbjct: 97 TIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKN 156 Query: 98 YQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 157 P + I R D Y ++ AD A K++ ++ GVK+ Sbjct: 157 IPRLVPGWTKP----ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNF 212 Query: 158 CGIGIKPCSEEGTKRLVRAA---IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 G+ + + A +YAI + + + K I+K +G FKD ++ Sbjct: 213 PAGGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEIFD 271 Query: 215 EEFG 218 + + Sbjct: 272 KHYK 275 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 43.8 bits (102), Expect = 0.004, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 27/66 (40%) Query: 147 MGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 206 + E + S++G + +R A + A R VTL++K ++G+ Sbjct: 4 FNELEYSPVEGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLV 63 Query: 207 DWGYQL 212 + +L Sbjct: 64 EAAQRL 69 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 41.9 bits (97), Expect = 0.014, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 28/69 (40%), Gaps = 5/69 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V P + V+ A S+ E+ G + + G V LP ETL ++ Sbjct: 51 VGNEVIPVAVDVLCLAGSL---EGIDFSFEELPIGGVALDLVG--VPLPKETLIRAKQSD 105 Query: 61 VAIKGPLTT 69 + G + Sbjct: 106 ALLLGAVGW 114 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 256 4e-67 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 253 5e-66 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 249 6e-65 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 245 9e-64 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 244 1e-63 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 239 6e-62 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 238 1e-61 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 232 6e-60 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 231 1e-59 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 230 3e-59 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 229 4e-59 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 229 5e-59 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 227 2e-58 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 224 1e-57 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 220 3e-56 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 212 6e-54 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 212 7e-54 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 210 2e-53 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 209 8e-53 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 206 4e-52 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 206 6e-52 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 206 7e-52 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 203 3e-51 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 203 4e-51 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 202 7e-51 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 202 9e-51 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 201 2e-50 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 200 3e-50 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 200 3e-50 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 199 4e-50 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 198 1e-49 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 198 1e-49 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 196 5e-49 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 196 6e-49 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 195 1e-48 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 195 1e-48 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 194 2e-48 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 192 9e-48 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 190 2e-47 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 190 2e-47 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 190 4e-47 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 189 6e-47 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 189 8e-47 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 188 1e-46 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 187 2e-46 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 187 2e-46 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 187 3e-46 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 187 3e-46 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 185 6e-46 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 185 9e-46 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 184 1e-45 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 183 5e-45 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 182 7e-45 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 182 7e-45 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 182 8e-45 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 180 2e-44 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 180 3e-44 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 180 3e-44 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 180 3e-44 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 180 3e-44 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 180 3e-44 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 180 4e-44 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 179 4e-44 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 179 6e-44 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 179 6e-44 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 179 7e-44 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 179 7e-44 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 179 8e-44 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 178 1e-43 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 178 1e-43 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 177 3e-43 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 177 3e-43 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 176 6e-43 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 176 6e-43 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 175 7e-43 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 175 7e-43 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 175 1e-42 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 174 2e-42 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 172 7e-42 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 172 9e-42 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 171 1e-41 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 171 1e-41 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 171 2e-41 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 170 2e-41 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 170 2e-41 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 170 3e-41 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 170 3e-41 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 170 4e-41 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 170 4e-41 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 169 5e-41 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 169 5e-41 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 169 6e-41 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 169 9e-41 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 167 2e-40 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 167 2e-40 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 167 3e-40 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 166 5e-40 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 165 1e-39 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 164 2e-39 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 164 3e-39 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 164 3e-39 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 163 4e-39 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 161 1e-38 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 161 1e-38 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 161 2e-38 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 161 2e-38 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 161 2e-38 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 160 2e-38 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 160 3e-38 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 159 5e-38 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 159 8e-38 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 159 9e-38 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 158 1e-37 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 158 1e-37 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 157 2e-37 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 157 4e-37 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 156 4e-37 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 156 5e-37 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 156 5e-37 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 156 6e-37 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 155 9e-37 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 154 2e-36 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 152 6e-36 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 151 2e-35 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 150 3e-35 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 150 3e-35 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 150 5e-35 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 149 8e-35 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 147 2e-34 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 147 3e-34 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 146 6e-34 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 144 2e-33 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 144 2e-33 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 144 2e-33 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 144 2e-33 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 144 3e-33 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 144 3e-33 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 142 8e-33 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 142 1e-32 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 141 2e-32 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 140 2e-32 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 140 4e-32 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 139 8e-32 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 138 9e-32 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 138 1e-31 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 137 2e-31 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 137 3e-31 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 137 4e-31 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 135 9e-31 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 131 2e-29 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 129 6e-29 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 128 2e-28 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 127 3e-28 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 127 4e-28 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 126 5e-28 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 125 8e-28 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 123 3e-27 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 120 3e-26 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 118 1e-25 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 118 1e-25 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 115 2e-24 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 110 5e-23 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 106 5e-22 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 106 6e-22 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 105 8e-22 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 105 8e-22 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 105 8e-22 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 103 4e-21 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 100 4e-20 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 100 7e-20 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 98 2e-19 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 96 9e-19 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 95 1e-18 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 93 6e-18 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 90 4e-17 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 90 7e-17 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 88 2e-16 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 84 5e-15 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 80 6e-14 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 77 3e-13 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 73 8e-12 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 69 2e-10 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 62 2e-08 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 58 3e-07 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 57 6e-07 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 46 9e-04 Sequences not found previously or not previously below threshold: UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 99 1e-19 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 83 6e-15 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 82 1e-14 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 71 2e-11 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 70 4e-11 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 63 8e-09 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 63 9e-09 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 62 1e-08 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 60 6e-08 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 58 3e-07 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 58 3e-07 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 57 5e-07 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 53 1e-05 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 52 1e-05 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 45 0.002 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 43 0.007 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 40 0.067 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 256 bits (654), Expect = 4e-67, Method: Composition-based stats. Identities = 175/222 (78%), Positives = 200/222 (90%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVD++P M+KVVDAAVEKAYKGERKI+WME+Y GEK+TQVY QD WLP ETLD +R+Y Sbjct: 39 IGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTWLPQETLDAVRDYV 98 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGGIRSLNVALRQ+LDLY+C RPVR+++G PSPVK P DMVIFRENS Sbjct: 99 VSIKGPLTTPVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPVKKPGDVDMVIFRENS 158 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAG+EWKA S +AEKVIKFL EEMGVKKIRF E+CGIGIKP S+EGTKRLVR A++Y Sbjct: 159 EDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPVSQEGTKRLVRKALQY 218 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A+ NDR SVTLVHKGNIMKFTEGAFKDWGY++AR+EFG EL+ Sbjct: 219 AVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELL 260 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 253 bits (645), Expect = 5e-66, Method: Composition-based stats. Identities = 147/222 (66%), Positives = 178/222 (80%), Gaps = 2/222 (0%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG D+ A +V+DAAVEKAY GE++I W E+ G+K+ G+ WLP ETLD I+EY Sbjct: 29 IGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGE--WLPQETLDTIKEYL 86 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+KGPLTTP+GGGIRSLNVALRQELDL+ CLRPVR+++G PSPVK P+ DMVIFREN+ Sbjct: 87 IAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENT 146 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE+K + + +KVI FL+ EMG IRFPE GIGIKP S+EGT+RLVRAAI+Y Sbjct: 147 EDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLVRAAIQY 206 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N+R SVTLVHKGNIMKFTEG+FK WGY LA EFG ++ Sbjct: 207 AIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVF 248 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 249 bits (635), Expect = 6e-65, Method: Composition-based stats. Identities = 157/222 (70%), Positives = 189/222 (85%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVTP MLKVV+AAV KAY G+RKI W+E+Y GEK+T++Y + WLP ETL++++EY+ Sbjct: 37 IGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYK 96 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGG+ SLNVA+RQ LDLY+C RPV+++ G PSPVK P DMVIFREN+ Sbjct: 97 VSIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENT 156 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE+KA S A+ VIKFL EEMG IRF E+CGIGIKP S+EG++RLVR AI+Y Sbjct: 157 EDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQY 216 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N++DSVTLVHKGNIMKFTEGAFKDWGY+LA EEFG L+ Sbjct: 217 AIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLL 258 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 245 bits (625), Expect = 9e-64, Method: Composition-based stats. Identities = 94/220 (42%), Positives = 128/220 (58%), Gaps = 15/220 (6%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT AM V++A + W+ + G + + YG LP + L+ IRE R Sbjct: 13 IGPEVTRAMTTVLEA-------SGVDLEWIRVEAGVEVIEKYGTP--LPPQVLESIRETR 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGP+ TPVG G RS+NVA+R+ELDLY LRP + G SP + D+V+ REN+ Sbjct: 64 VAIKGPIGTPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF---QDIDLVVVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE++ + +A + + G E IGIKP SE G++R+V+ A EY Sbjct: 121 EDLYAGIEFERGTPEAAHAREEMMRLSGKF---IREGSAIGIKPISEFGSRRIVKFAFEY 177 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A N R VT VHK NIMKFT+G F ++A+E E Sbjct: 178 ARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIE 217 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 244 bits (624), Expect = 1e-63, Method: Composition-based stats. Identities = 131/223 (58%), Positives = 161/223 (72%), Gaps = 4/223 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DV PA KV++AA E R ISWM +Y GE + + YG+DV LP ET+D IRE+R Sbjct: 41 IGKDVGPAAQKVLEAAAE---ATGRDISWMRVYAGESAREEYGEDVNLPDETVDAIREHR 97 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGPLTTPVG G RSLNVALRQ LDLY +RP Y G PSP+K PE DMV FREN+ Sbjct: 98 VAIKGPLTTPVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPMKAPEEMDMVTFRENT 157 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW+A + + E+V +F+ +EMG + GIG+KP +E+G+KRLVR AI+Y Sbjct: 158 EDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPITEKGSKRLVREAIDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA-REEFGGELI 222 A+ +DRD VTLVHKGNIMKFTEG F DWG ++A E E+ Sbjct: 218 ALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVF 260 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 239 bits (609), Expect = 6e-62, Method: Composition-based stats. Identities = 126/228 (55%), Positives = 167/228 (73%), Gaps = 7/228 (3%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G+D+ PA KV+DAAV KAY G+RKISW ++Y G+++ +YG +LP +TL I+EY + Sbjct: 38 GIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQYLPQDTLTAIKEYGI 97 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 AIKGPLTTP+GGGIRSLNVALRQ DLY C+RP RYY GTPSP K P+ D++++REN+E Sbjct: 98 AIKGPLTTPIGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKSPDKLDVIVYRENTE 157 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVK-----KIRFPEHCGIGIKPCSEEGTKRLVRA 176 DIY GIEWK S E++I L +++ K + P GIGIKP S G++RLVR Sbjct: 158 DIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIPLDAGIGIKPISRSGSQRLVRR 217 Query: 177 AIEYAIANDRDS--VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A+++A+ ++ VTLVHKGNIMK+TEGAF+DWGY+LA +EF E + Sbjct: 218 ALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELATQEFRAECV 265 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 120/222 (54%), Positives = 160/222 (72%), Gaps = 3/222 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A V DAAV+KAY G+++++W+ + GE + + GQ WLP +TL +REY Sbjct: 29 IGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQ--WLPDKTLATLREYL 86 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGPLTTP+G G RS+NV LRQ+LDLY C RPV YY GTPSPV HPE ++ +FREN+ Sbjct: 87 VGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPVVHPENVNIDVFRENT 146 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIE D+ DAE+ L ++ + K+RFP+ IKP S++G+ RLV AAI+Y Sbjct: 147 EDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIKPISKQGSTRLVDAAIDY 206 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A AN+R ++TLVHKGNIMK TEG FK WGY+ A E++G ++ Sbjct: 207 AFANNRHTLTLVHKGNIMKKTEGGFKKWGYE-AAEKYGDKVF 247 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 232 bits (592), Expect = 6e-60, Method: Composition-based stats. Identities = 88/219 (40%), Positives = 125/219 (57%), Gaps = 14/219 (6%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A +V++A W G + G LP L+ IR +V Sbjct: 14 GPELAEATRRVLEA-------TGVAFDWDIQDAGVDVMEQLGTP--LPDSVLESIRSTKV 64 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+K P+TTPVG G RS+NVA+R+ELDLY C+RP R Y G S E D+V+ REN+E Sbjct: 65 ALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRF---ENIDLVVVRENTE 121 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 D+YAGIE++ + + ++ +L ++ I+ P GI IKP S G++R+VR A EYA Sbjct: 122 DLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPG--GISIKPMSVPGSERIVRFAFEYA 179 Query: 182 IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 AN R VT VHK NIMKF++G F + ++A+E E Sbjct: 180 RANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIE 218 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 231 bits (590), Expect = 1e-59, Method: Composition-based stats. Identities = 147/229 (64%), Positives = 186/229 (81%), Gaps = 8/229 (3%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG-------QDVWLPAETL 53 IG D+TPAM+KVVD+AV+KAYKGE+KI+W E++ GEK Q + ++ WL +T+ Sbjct: 40 IGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLPDTI 99 Query: 54 DLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 + I Y+V+IKGPLTTP+G G RSLNVALRQ++DLY+CLRPVR+Y G+PSPVK P+ DM Sbjct: 100 EAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWY-GSPSPVKEPQKVDM 158 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 VIFRENSEDIYAGIEW+ SA+A+K+I FL+ E+ V+KIRFPE G+GIKP S+EGT+RL Sbjct: 159 VIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPISKEGTERL 218 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 VR AIEYAI ND+ SVT VHKGNIMK+TEGAF WGY LA++EF ++I Sbjct: 219 VRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQVI 267 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 230 bits (586), Expect = 3e-59, Method: Composition-based stats. Identities = 115/222 (51%), Positives = 161/222 (72%), Gaps = 5/222 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A +KV + AVEKAY R+I+W EI GEK+ +++G LP ++++++R+ R Sbjct: 55 IGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGN--RLPDQSIEVLRKIR 112 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K PL TPVGGG RS+NV LRQ DLY +RPV+Y+ G PSP++ PEL D+VIFREN+ Sbjct: 113 VFLKAPLETPVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPLRRPELVDLVIFRENT 172 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW +S +A K+ +FLR E GV + GIGIKP S+ GT+R+ R A+++ Sbjct: 173 EDVYAGIEWPYNSPEAAKIREFLRREFGV---NIRDDAGIGIKPISKFGTQRIARLALKF 229 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N R VT++HKGNI K+TEGAFK+W +++AR EF ++ Sbjct: 230 AIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVV 271 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 229 bits (585), Expect = 4e-59, Method: Composition-based stats. Identities = 116/222 (52%), Positives = 149/222 (67%), Gaps = 6/222 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + KV+DAAV+KAY G R+I W E+ GE++ + G LP TL + R Sbjct: 43 IGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECG--SLLPDGTLQAFKLAR 100 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPLTTPVGGG RSLNV LR LDLY +RPV++Y G P+P HPE D VIFREN+ Sbjct: 101 VNLKGPLTTPVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTPHCHPENIDWVIFRENT 159 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW DS +A+K+ FL++E G I GIGIKP S+ T+R VR A+E+ Sbjct: 160 EDVYAGIEWPFDSPEAQKIRDFLKKEFG---IELTPDTGIGIKPISKWRTQRHVRRAMEW 216 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI N VT++HKGNIMK+TEGAF+ W Y L EF ++ Sbjct: 217 AIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVV 258 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 229 bits (584), Expect = 5e-59, Method: Composition-based stats. Identities = 123/223 (55%), Positives = 156/223 (69%), Gaps = 6/223 (2%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DV PA KV++AA A R+ISWM ++ GE + + Y ++ LP +T++ I E+R Sbjct: 43 IGKDVGPAAQKVLEAA---ANATGREISWMRVFAGESAREKYDEN--LPDDTVNAIDEHR 97 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VAIKGPLTTPVG G RSLNVALRQ LD Y +RP Y G PSP+K PE DMV FREN+ Sbjct: 98 VAIKGPLTTPVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKAPEEMDMVTFRENT 157 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIEW+A + + E+V +F+ E+MG + GIGIKP +E G+KRLVR AI+Y Sbjct: 158 EDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGSKRLVRKAIDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA-REEFGGELI 222 AI +DRD VTLV KGNIMKFTEG F +WG ++A E E+ Sbjct: 218 AIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVF 260 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 227 bits (579), Expect = 2e-58, Method: Composition-based stats. Identities = 123/228 (53%), Positives = 160/228 (70%), Gaps = 7/228 (3%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 GVD+ PA V++AA+ KAY G +I+W ++Y G+++ ++YG P +TL I+EY V Sbjct: 38 GVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDTLTAIKEYGV 97 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 AIKGPLTTPVGGGIRSLNVALRQ DLY C+RP RYY GTPSP K PE D++++REN+E Sbjct: 98 AIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHKTPEKLDIIVYRENTE 157 Query: 122 DIYAGIEWKADSADAEKVIKFLREEM-----GVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 DIY GIEW + A+K+I +L +E+ + K + GIGIKP S+ G++RLVR Sbjct: 158 DIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRLDSGIGIKPISKTGSQRLVRR 217 Query: 177 AIEYAIANDRDS--VTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 AI +A + VTLVHKGNIMKFTEG F+DWGY+LA EF E + Sbjct: 218 AILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELATTEFRAECV 265 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 224 bits (572), Expect = 1e-57, Method: Composition-based stats. Identities = 120/219 (54%), Positives = 173/219 (78%), Gaps = 1/219 (0%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G DV P M KVVD+A+ Y+ +RKI WM++Y GE++ ++Y D W P ET++ +RE + Sbjct: 42 VGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGD-WFPQETINAVRECK 100 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +AIKGPLTTP+GGG RSLNVALRQE+DL++ +R ++ + PSP+K+P LT++ + R++S Sbjct: 101 IAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPYLTNITVLRDSS 160 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y+GIEW+A S ++EKV+ FL EEMGV ++RF + CGIGIK S+EG++RLVR AI Y Sbjct: 161 EDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISKEGSERLVRYAINY 220 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A+ N+ +S+TLVHKGN++KFT+GAFK WG+ LA+ E+ Sbjct: 221 ALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQA 259 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 220 bits (560), Expect = 3e-56, Method: Composition-based stats. Identities = 72/220 (32%), Positives = 104/220 (47%), Gaps = 33/220 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A++ ++ AA + + GE+ G +P E D I R Sbjct: 32 IGPEITAAVMSILSAA-------GAHLDAEYVEVGEQVYLR-GNTSGIPQEAWDSIARTR 83 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGP+TTP GGG +SLNV +R+ L LY +RP R Y+ P D+VI REN Sbjct: 84 VMLKGPITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK--PIVTTRHPDMDVVIVRENE 141 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE R + +K + G++R+ R A EY Sbjct: 142 EDLYAGIEH-----------------------RQTQDVAQCLKLITRSGSERIARYAFEY 178 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + R +T + K NIMK T+G F ++ARE + Sbjct: 179 ARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQ 218 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 212 bits (540), Expect = 6e-54, Method: Composition-based stats. Identities = 110/223 (49%), Positives = 161/223 (72%), Gaps = 4/223 (1%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T AML +++ AVEK Y G +KI W+E+ G+K+ + G+ LP ETLD+++E Sbjct: 49 IGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGE--RLPQETLDVLKESI 106 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGPL TPVG G+RS+N ALR+ D Y +RPV Y+ G +P+ +PE D+V+FREN+ Sbjct: 107 VGIKGPLGTPVGKGVRSINSALRRAFDYYSAVRPV-YWMGQATPIPNPERVDLVVFRENT 165 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 +D+YAG+E+ A + +A+KV +FL +EMG K+ FPE GI +KP SE TKR VR A+ Y Sbjct: 166 DDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEFKTKRHVRKALRY 225 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE-EFGGELI 222 A+ N++ +V ++ KGNIMK TEGAF +W +++A E EF G+++ Sbjct: 226 ALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVV 268 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 212 bits (540), Expect = 7e-54, Method: Composition-based stats. Identities = 62/219 (28%), Positives = 103/219 (47%), Gaps = 35/219 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT A ++V++A K W G ++ + Y + ++P E + I R Sbjct: 13 IGPEVTSAAVRVLEA-------TGLKFEWESFAAGAEAYEKYKE--YIPKELNESIERTR 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGP+TTP+GGG S+NV LR+ +LY +RP+R G + D+V+ REN+ Sbjct: 64 IGLKGPVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRYP---GVDLVVVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+GIE + E +K +E+ + R+ + A Y Sbjct: 121 EGLYSGIEHEVVPGVVE-----------------------SLKIITEKASTRISKFAFNY 157 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A R + +HK NIMK ++G F +++E Sbjct: 158 ARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEYPEI 196 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 210 bits (535), Expect = 2e-53, Method: Composition-based stats. Identities = 68/220 (30%), Positives = 107/220 (48%), Gaps = 35/220 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A+ ++ A + I W + + T+ +P +LD+IR++ Sbjct: 1987 IGPEISAAVQEIFKFA-------DVPIKWESVDVTPRPTE--DGRFRMPQSSLDIIRKHG 2037 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGPL TP+G G +SLN+ALR+E +LY +RP + +G +P K D+V REN+ Sbjct: 2038 IGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYK---NVDLVTVRENT 2094 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK +EE ++R+ R A +Y Sbjct: 2095 EGEYSGIEHVIVDGVVQ-----------------------SIKLITEEASRRVARFAFQY 2131 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A N R SVT VHK NIM+ ++G F + A E Sbjct: 2132 AKDNGRRSVTAVHKANIMRMSDGLFLRVCREEAAHHREIE 2171 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 209 bits (531), Expect = 8e-53, Method: Composition-based stats. Identities = 54/220 (24%), Positives = 96/220 (43%), Gaps = 41/220 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ +V A I W + + + E ++ I + + Sbjct: 34 IGPEISESVKRVFSAVKA-------PIEWETVVV--------DANTGISKEVIESISKNK 78 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGP++TP+G G +SLN+ LR+ +LY +RP G + + V+ REN+ Sbjct: 79 IGLKGPISTPIGTGHQSLNLGLRKTFNLYANIRPCLSIPGHKTRY---NNVNTVVVRENT 135 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK ++E + R+ A +Y Sbjct: 136 EGEYSGIENQPVKG-----------------------VAQSIKIITKEASTRIAHYAFQY 172 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A+AN R VT +HK NIMK ++G F +++ + Sbjct: 173 ALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIK 212 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 206 bits (525), Expect = 4e-52, Method: Composition-based stats. Identities = 59/220 (26%), Positives = 95/220 (43%), Gaps = 35/220 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A+ + AA + I W K G + E+L+ + Y+ Sbjct: 315 IGPEISQAVCDIFAAA-------KVPIDWEHHEIYTKPINEAGD--LIKEESLNAVINYK 365 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +KGP TP+G G RSLNV +R++L+L+ +RP R G +P D+V REN+ Sbjct: 366 WGLKGPFATPIGKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYS---NVDLVTIRENT 422 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+G+E E +K S+ + + R A E+ Sbjct: 423 EGEYSGLEHAVVPGVVEN-----------------------LKIISQPACENIARYAFEF 459 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A N+R V HK +MK +G F + +++ E E Sbjct: 460 ARKNNRKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIE 499 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 206 bits (523), Expect = 6e-52, Method: Composition-based stats. Identities = 63/214 (29%), Positives = 99/214 (46%), Gaps = 35/214 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ A++K+ DAA I W E + Q G +P+E + + + + Sbjct: 42 IGPEISAAVMKIFDAAKA-------PIQWEERNV--TAIQGPGGKWMIPSEAKESMDKNK 92 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +KGPL TP+ G S+N+ LR+ DLY +RP +G +P ++V REN+ Sbjct: 93 MGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT---DVNIVTIRENT 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK +E +KR+ A EY Sbjct: 150 EGEYSGIEHVIVDGVVQ-----------------------SIKLITEGASKRIAEFAFEY 186 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 A N R +VT VHK NIM+ ++G F ++A Sbjct: 187 ARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAE 220 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 206 bits (523), Expect = 7e-52, Method: Composition-based stats. Identities = 60/220 (27%), Positives = 103/220 (46%), Gaps = 36/220 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ + AA I W + G+ +P + ++ +R Sbjct: 65 IGPEISQSVKDIFSAANA-------PIKWEPVDV--TPILKDGK-TAIPDDAIESVRRNY 114 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VA+KGPL TPVG G SLN+ LR+ +L+ +RP R G +P + D V+ REN+ Sbjct: 115 VALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---DNVDTVLIRENT 171 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK ++E ++R++R A +Y Sbjct: 172 EGEYSGIEHVVVDGVVQ-----------------------SIKLITKEASERVLRFAFQY 208 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + ++ V +VHK IMK ++G F + ++A++ E Sbjct: 209 ARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVE 248 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 203 bits (517), Expect = 3e-51, Method: Composition-based stats. Identities = 65/219 (29%), Positives = 101/219 (46%), Gaps = 40/219 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG VT A+ +V++A + +V G +P E ++ ++ + Sbjct: 49 IGPLVTGAVEQVMEAM--------------HAPVHFERYEVLGNMRKVPEEVIESVKRNK 94 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KG L TPVGGG+ SLN+ LR+ELD++ L G V E D+V+ REN+ Sbjct: 95 VCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGL---VTRHENVDIVVIRENT 151 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+G+E + E +K ++ ++R+ R A EY Sbjct: 152 EGEYSGLEHEVVPGVVE-----------------------SLKVITKFCSERIARYAFEY 188 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A N+R VT VHK NIMK +G F + ++A+ G Sbjct: 189 AYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGI 227 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 203 bits (516), Expect = 4e-51, Method: Composition-based stats. Identities = 60/221 (27%), Positives = 96/221 (43%), Gaps = 36/221 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ K+ AA I W +P + I + Sbjct: 47 IGPEISKSVKKIFSAA-------NVPIEWESCDVSPIFVN---GLTTIPDPAVQSITKNL 96 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 VA+KGPL TP+G G RSLN+ LR+ L+ +RP + +G + E D+V+ REN+ Sbjct: 97 VALKGPLATPIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---ENVDLVLIRENT 153 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK + + ++R++R A EY Sbjct: 154 EGEYSGIEHIVCPGVVQ-----------------------SIKLITRDASERVIRYAFEY 190 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A A R V +VHK I + +G F + +L++E L Sbjct: 191 ARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTL 231 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 202 bits (514), Expect = 7e-51, Method: Composition-based stats. Identities = 64/220 (29%), Positives = 99/220 (45%), Gaps = 33/220 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A LKV+ + ++ +I G K + G + + + ++ + Sbjct: 14 IGPEIMDATLKVI-------LEAGAELEIEKIEIGFKVYSM-GNPSGIEPSSWESLKRTK 65 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K P+TTP GGG +SLNV +R+ L LY +RP Y P D+VI REN Sbjct: 66 VFLKAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY--APFIHTKHPGIDLVIIRENE 123 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y GIE + +K + +GT+R++R A EY Sbjct: 124 EDLYGGIEHRQGV-----------------------DSFQALKIMTRQGTERIIRYAFEY 160 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A R V+ K NI+K T+G F ++A+E E Sbjct: 161 ARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIE 200 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 202 bits (513), Expect = 9e-51, Method: Composition-based stats. Identities = 66/222 (29%), Positives = 102/222 (45%), Gaps = 35/222 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A++ V+ A + I GEK Y + +T I + Sbjct: 15 IGPEIMEAVVYVLKEAA-------VPLRLETIEIGEKLYNKY-YTYGITEDTWSQIFRTK 66 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRP-VRYYQGTPSPVKHPELTDMVIFREN 119 +KGP+TTP GGG +SLNV LR+ L LY +RP Y+ + D+VI REN Sbjct: 67 ALLKGPVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSYFPFVNTSAPE---IDVVIIREN 123 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 ED+YAGIE+ +K S G+++++R A E Sbjct: 124 EEDLYAGIEYHH-----------------------TADTYESVKLISRSGSEKIIRFAFE 160 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 YA+ N+R +++ K NIMKFT+G F ++A + ++ Sbjct: 161 YALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQV 202 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 201 bits (510), Expect = 2e-50, Method: Composition-based stats. Identities = 135/183 (73%), Positives = 157/183 (85%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG+D++P M+KVVDAAV+KAY GERKISWME+Y GEK+TQVY QD WLP ETLD +++Y Sbjct: 39 IGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQETLDAVKDYV 98 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V+IKGPLTTPVGGGIRSLNVALRQ+LDLY+CLRPVR+++G PSPVK P DM IFRENS Sbjct: 99 VSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVKKPGDVDMTIFRENS 158 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 EDIYAGIEWKA S +A KVIKFL+EEMGV KIRF + CGIG+KP S+EGTKRL R A+ Sbjct: 159 EDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGVKPVSKEGTKRLARKALHS 218 Query: 181 AIA 183 A A Sbjct: 219 AEA 221 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 200 bits (509), Expect = 3e-50, Method: Composition-based stats. Identities = 66/220 (30%), Positives = 102/220 (46%), Gaps = 32/220 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + ++++A I W G + G +P +T++ I+ R Sbjct: 31 IGPEIVESACRLIEAV-------GAPIEWEVRRAGASVFRE-GIASGVPDDTIESIKRTR 82 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPL TPVG G +S NV LR+ + + +RPVR P+P + D+V+ REN Sbjct: 83 VVLKGPLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG-RNIDLVVVRENI 141 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YA IE++ I K S +G+++++R A E Sbjct: 142 EDLYAAIEYRETPGVT-----------------------IAHKLISYKGSEKIIRFAFEL 178 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A A R VT K NI+K TEG F+ ++A E E Sbjct: 179 ARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIE 218 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 200 bits (508), Expect = 3e-50, Method: Composition-based stats. Identities = 52/224 (23%), Positives = 91/224 (40%), Gaps = 28/224 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A L+V++A ++ G+ I G + G V +PA+ L+ ++++ Sbjct: 14 IGPEVIAAGLQVLEALEKR--SGDFSIHTETFDWGSDYYKKNG--VMMPADGLEQLKKFD 69 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK--HPELTDMVI 115 G + P + L + + Q D Y +RP + G P++ P D VI Sbjct: 70 AIFFGAVGAPDVPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLRNCGPGDLDWVI 129 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RENSE Y+G +A PE G + + G R++R Sbjct: 130 VRENSEGEYSGHGGRAHKG-------------------LPEEVGTEVAIFTRVGVTRIMR 170 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A + A A R +T+V K N + + + ++++E Sbjct: 171 YAFKLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDV 214 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 199 bits (507), Expect = 4e-50, Method: Composition-based stats. Identities = 54/223 (24%), Positives = 96/223 (43%), Gaps = 27/223 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++V A ++VV+ + G I + I G + +G+ ++ + LD +R++ Sbjct: 57 IGIEVVDAAIQVVEKLAKTL--GTFNIDFTHIPWGTAYYKEHGR--YVSEDCLDTLRKFD 112 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP-ELTDMVIF 116 + G + P + L +ALR L LY +RPVR + GT P+ E D ++ Sbjct: 113 AGLFGAVGAPDVPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLNTATEGIDWMLV 172 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RENSE Y+G + G + P + + G +R++R Sbjct: 173 RENSEGEYSG-------------------QGGRSHVGQPWEAATEVAMFTRVGIERIMRF 213 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A E A + R +T+V K N M+ + ++A++ Sbjct: 214 AFEVAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDV 256 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 198 bits (504), Expect = 1e-49, Method: Composition-based stats. Identities = 75/220 (34%), Positives = 106/220 (48%), Gaps = 12/220 (5%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A V+D A KI W G+++ + LP TL+ IR Sbjct: 15 GPELVDAARSVLDHAARL---SGFKIDWDVHQAGQRALAE--SESLLPDATLNSIRTNGA 69 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL--TDMVIFREN 119 A+KGP TTP+G G RS+N+ +RQELDLY CLRPVR S + PE D+V+ REN Sbjct: 70 ALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEEPERPHVDLVVVREN 128 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +ED+YAG+E+ S A V++ L G P + +KP + G +R+V A Sbjct: 129 TEDVYAGLEYPKGSPGARAVVQAL----GALGRPLPADTAVSLKPFTPHGCERVVEFAFN 184 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 +A + R V V TEG F ++A Sbjct: 185 HAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSI 224 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 198 bits (503), Expect = 1e-49, Method: Composition-based stats. Identities = 64/220 (29%), Positives = 105/220 (47%), Gaps = 36/220 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ ++L+++ ++ +I I G+K + G + + ++ + Sbjct: 12 VGPEIMTSVLEII-------FEAGAEIQIDTIEIGQKIYEK-GWPSGISDSGWETLKRNK 63 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K P+TTP GGG+RSLNV LR++L L+ +RP + + P D+VI REN Sbjct: 64 VLLKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCKSHLEWQDP-----KMDIVIIRENE 118 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y+GIE+ R K +E ++R+ R A EY Sbjct: 119 EDLYSGIEY-----------------------RQTLDTYNCTKVITESTSERICRYAFEY 155 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A +N R VT++ K NIMK T+G F ++A E E Sbjct: 156 ARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIE 195 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 196 bits (498), Expect = 5e-49, Method: Composition-based stats. Identities = 70/218 (32%), Positives = 99/218 (45%), Gaps = 31/218 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ +++ V+DA W Y G + G LP ET+ I + Sbjct: 23 IGPEIVESVVSVLDAL-------GSPFEWDSQYAGMAAIARVGDP--LPRETIQSIHHNK 73 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+KGPLTTP GGG RS+NV LR+E +L+ +RP P E D+ + REN Sbjct: 74 LALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTL----IPGGRFENVDITLIRENL 129 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + YA E D P + + G R++R A EY Sbjct: 130 DGFYAAFEHYMPIGD------------------DPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 A+ N R VTLVHK NI+K G F + G ++A+E G Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEG 209 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 196 bits (497), Expect = 6e-49, Method: Composition-based stats. Identities = 51/225 (22%), Positives = 86/225 (38%), Gaps = 28/225 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + + E G + + G + +G V +PA+ L+ +R+ Sbjct: 14 IGKEVIPAGRQAMQVLAET--DGSFTFEFQDFDWGGDYYRRHG--VMMPADGLEPLRDKD 69 Query: 61 VAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 + G P + L + + Q LD Y +RP R G P+K E D VI Sbjct: 70 AILFGSAGDPDIADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLKRCTAEQLDWVI 129 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RENSE Y+G+ + P + + G +R++R Sbjct: 130 VRENSEGEYSGVGGRVHQG-------------------LPIEAATDVSMMTRAGVERILR 170 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A A + R +T+V K N + + + +++RE Sbjct: 171 YAFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVR 215 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 195 bits (495), Expect = 1e-48, Method: Composition-based stats. Identities = 70/221 (31%), Positives = 112/221 (50%), Gaps = 33/221 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G DV A L V+DA +K I ++ G + + YG + LP ETLD ++E Sbjct: 16 VGPDVINASLLVLDAVKKKF---NLDIEYVPAVAGLNTVEKYGTN--LPKETLDTLKETD 70 Query: 61 VAIKGPLTTPVGG-GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +KGP TTP G + S NV +R+ DLY +RP + PS DMVI REN Sbjct: 71 CVLKGPTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI---KPNVDMVIVREN 127 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E +Y+G++++ + + IGI+ + + +R+V+ A + Sbjct: 128 TEGMYSGLDFRVN-----------------------QETTIGIRVITRKACERIVKYAFK 164 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + + VTLVHKGN++K ++G FKD Y+ A++ + Sbjct: 165 LAESR-KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVK 204 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 195 bits (495), Expect = 1e-48, Method: Composition-based stats. Identities = 73/222 (32%), Positives = 103/222 (46%), Gaps = 32/222 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + A LKV++AA +++ G + G +P ET++ IR+ R Sbjct: 30 IGPECVEATLKVLEAAKA-------PLAYEVREAGASVFRR-GIASGVPQETIESIRKTR 81 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +KGPL TPVG G +S NV LR+ + Y +RPVR + P+P D+V+ REN Sbjct: 82 VVLKGPLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG-RGIDLVVVRENV 140 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE +K S +G++++VR A E Sbjct: 141 EDLYAGIEH-----------------------MQTPSVAQTLKLISWKGSEKIVRFAFEL 177 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A A R V K NIMK EG K Q+A+E E + Sbjct: 178 ARAEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAV 219 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 194 bits (493), Expect = 2e-48, Method: Composition-based stats. Identities = 61/225 (27%), Positives = 92/225 (40%), Gaps = 30/225 (13%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G + LKV+ AA K + + G + G+ LP + ++ ++ Y Sbjct: 28 GPEQVREGLKVLHAAAGK---EGFALETTVLDWGGEYYLRTGE--VLPPDAVEQLKRYDA 82 Query: 62 AIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVIF 116 G + P G + + + LR ELD YI LRPV+ Y G +P+ K PE D V+ Sbjct: 83 IYLGAIGHPEVRPGILEKGILLRLRFELDQYINLRPVKLYPGVETPIAGKGPEDIDFVVV 142 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E +YAG G K P+ I + +G +R VR Sbjct: 143 RENTEGLYAG-------------------SGGFLKRGTPDEVAIQTSINTRKGVERCVRF 183 Query: 177 AIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A EY R VTL K N++ F ++ ++ E E Sbjct: 184 AFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIE 228 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 192 bits (487), Expect = 9e-48, Method: Composition-based stats. Identities = 52/220 (23%), Positives = 91/220 (41%), Gaps = 40/220 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + +++ + + G+++ + YG+ LP ETL+ R+ Sbjct: 12 IGKEVMEAAMLILEKL-------DLPFEYSYYDAGDEALEKYGK--ALPDETLEACRKSD 62 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V LR+EL + +RP + +G D+V+ REN+ Sbjct: 63 AVLFGAA----GETAADVIVRLRRELGTFANVRPAKAIEGIECLYP---GLDIVVVRENT 115 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y G E+ I+ + E ++R+ R A E Sbjct: 116 ECLYMGFEFGFG------------------------DVTEAIRVITREASERIARYAFEL 151 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A R VT +HK N+MK T G F+D ++A++ + Sbjct: 152 AKREGRKKVTALHKANVMKKTCGLFRDVCREVAKDYPEIQ 191 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 190 bits (484), Expect = 2e-47, Method: Composition-based stats. Identities = 58/219 (26%), Positives = 102/219 (46%), Gaps = 15/219 (6%) Query: 7 PAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQV------YGQD--VWLPAETLDLIRE 58 + +++ A+ + I W+ G + G +P ET+D IR Sbjct: 24 DSGFDMMEGALVVLLSMDLPIDWVRADLGWCMWEKSVNKFGQGDPRCNTVPPETIDKIRS 83 Query: 59 YRVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + +T+ G G +S + +RQ DLYI LRP + SP+K D+V+FR Sbjct: 84 SDATLMAAITSKSGVKGFKSAILQMRQLFDLYINLRPAKTLPDLGSPLKGDPKIDLVLFR 143 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+ED+Y+ +E+ + + K G+++ R + + S G +R++RAA Sbjct: 144 ENTEDLYSAVEFHPLPEEMFNLHK------GMERFRKMGDVAVSWRVFSSVGCERIIRAA 197 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 EYA + R V +K N+++ T+G K ++A+E Sbjct: 198 FEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEY 236 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 190 bits (484), Expect = 2e-47, Method: Composition-based stats. Identities = 55/220 (25%), Positives = 94/220 (42%), Gaps = 36/220 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ + L +++A + + ++ G+ + G+ LP ET + I+ Sbjct: 15 IGPEISESALSILEAINDNFP---LSLEIKKLEAGDAVLKNTGK--ALPDETFEAIKNSD 69 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +K P+ G + + V LR+ LDLY +RP + Y PS + D+VI REN+ Sbjct: 70 ACLKAPV----GESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL---RDDVDLVIVRENT 122 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y G E+ + + SE+ +KR+ A Sbjct: 123 EDLYTGEEFDIG------------------------DAAVAFRIISEKASKRIANYAFTI 158 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A VT VHK N+MK T+G F ++A + + Sbjct: 159 ASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVK 198 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 190 bits (482), Expect = 4e-47, Method: Composition-based stats. Identities = 64/219 (29%), Positives = 101/219 (46%), Gaps = 33/219 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A+L ++ A + I I GEK + + ++ + I Sbjct: 15 IGPEIMEAVLYILRKAEAR-------IRLETIEVGEKLYVKH-YSSGISEQSWESIERTG 66 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V +K P+TTP GGG +SLNV +R+ L L+ +RP + P ++ I REN Sbjct: 67 VILKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSF--YPFTKTLHPNLNLTIIRENE 124 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+YAGIE+ R + +K S G ++++R A EY Sbjct: 125 EDLYAGIEY-----------------------RQTHNMYESVKLISRTGCEKIIRYAFEY 161 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A+ N+R VT + K NIMKF++G F ++A+E Sbjct: 162 AVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQI 200 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 189 bits (480), Expect = 6e-47, Method: Composition-based stats. Identities = 59/220 (26%), Positives = 93/220 (42%), Gaps = 40/220 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGV+V A L +++ + + ++ G+ + G LP ETL+ + E R Sbjct: 14 IGVEVMEAALHILNTL-------DLDLEFIHADAGDACLKRTG--TALPEETLEAVGEAR 64 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V LR+E DL+ LRPV+ G P D VI REN+ Sbjct: 65 ATLFGAA----GESAADVIVRLRREFDLFANLRPVKSLPGVPCLYP---DLDFVIVRENT 117 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y G E + + + + ++R+ + A +Y Sbjct: 118 EDLYVGDE------------------------EYTPEGAVAKRIITRTASRRISQFAFQY 153 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A VT VHK N++K T+G F+D Y++A E E Sbjct: 154 AQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQME 193 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 189 bits (479), Expect = 8e-47, Method: Composition-based stats. Identities = 49/221 (22%), Positives = 86/221 (38%), Gaps = 41/221 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + V A + + E++ + + ++ + IR R Sbjct: 27 IGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEEDIRNAIM------AIRRNR 73 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + T + +S N LR LDLY + + G V + D++I RE Sbjct: 74 VALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV---VTRHKDIDILIVRE 130 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+ +E ++ + E +K ++ + R+ A Sbjct: 131 NTEGEYSSLEHESVAGVVE-----------------------SLKIITKAKSLRIAEYAF 167 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 + A + R VT VHK NIMK +G F ++A Sbjct: 168 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQI 208 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 188 bits (477), Expect = 1e-46, Method: Composition-based stats. Identities = 75/218 (34%), Positives = 110/218 (50%), Gaps = 13/218 (5%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ A V+D A A + W G+ + + G+ LPA TLD IR V Sbjct: 15 GPELVAAARTVLDTA---AGSAGFHLDWDVRPAGQGALRSVGE--LLPASTLDSIRRNGV 69 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 A+KGP TTP+G G RS+N+ +R+ELDLY C+RPVR + G + D+V+ REN+E Sbjct: 70 ALKGPTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPGAGAV---DSGIDVVVVRENTE 126 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 D+Y+G+E+ ADS A V L E +KP + G++R+V A+++A Sbjct: 127 DVYSGLEYPADSDGAAVVSATLSEFGHA-----DPGIAFSLKPITPGGSRRIVAFALDHA 181 Query: 182 IANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 N R V + TEG F + +L E Sbjct: 182 RKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDI 219 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 187 bits (476), Expect = 2e-46, Method: Composition-based stats. Identities = 49/221 (22%), Positives = 86/221 (38%), Gaps = 41/221 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + V A + + E++ + + ++ + IR R Sbjct: 65 IGPELMLHVKSVFRHAC-------VPVDFEEVHVSSNADEEDIRNAIM------AIRRNR 111 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + T + +S N LR LDLY + + G V + D++I RE Sbjct: 112 VALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGV---VTRHKDIDILIVRE 168 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+ +E ++ + E +K ++ + R+ A Sbjct: 169 NTEGEYSSLEHESVAGVVE-----------------------SLKIITKAKSLRIAEYAF 205 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 + A + R VT VHK NIMK +G F ++A Sbjct: 206 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQI 246 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 187 bits (475), Expect = 2e-46, Method: Composition-based stats. Identities = 55/220 (25%), Positives = 89/220 (40%), Gaps = 41/220 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ + +V I + E+ ++S + L ++ Sbjct: 79 VGPELLSYVKEVFQVI-------GAPIDFEEVAVNQESEDATFT------DALLAMKRNG 125 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKG T G S NVALR L+LY ++ R + G V + D+VI REN+ Sbjct: 126 VGIKGNFATEPGQS--SRNVALRLNLNLYAFVQRCRNFPGV---VTRHQNVDIVIIRENT 180 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+ +E + E +K + E + R+ + A +Y Sbjct: 181 EGEYSRLEHENVPGVVE-----------------------SLKIITREKSTRIAQFAFDY 217 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A+ ++R VT VHK NIMK +G F D +A+ E Sbjct: 218 AVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIE 257 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 187 bits (474), Expect = 3e-46, Method: Composition-based stats. Identities = 49/225 (21%), Positives = 86/225 (38%), Gaps = 29/225 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V P ++V++AA K K+++ + Q +P++ ++ +R+ Sbjct: 17 IGNEVVPEGIRVLEAASAKF---GFKLAFTTYDWSCARY--HSQGSMMPSDGIERLRDSD 71 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVI 115 G + P + +L + +R+E D Y+ LRPVR G P P+ K P D I Sbjct: 72 AIFLGAVGFPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANKKPGDIDFWI 131 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E Y+ + G + GT R++R Sbjct: 132 VRENTEGEYS-------------------QVGGRMFAGTEHEFVTQEAIFTRRGTDRIMR 172 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + A R+ VT K N + + + + + E Sbjct: 173 YAFDLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIR 217 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 187 bits (474), Expect = 3e-46, Method: Composition-based stats. Identities = 54/226 (23%), Positives = 101/226 (44%), Gaps = 44/226 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V P +K+++ E ++ G + + YG LP +T++ +E Sbjct: 12 IGKEVIPEAIKILNELGE--------FEIIKGEAGLECLKKYGN--ALPEDTIEKAKEAD 61 Query: 61 VAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYY-------QGTPSPVKHPEL 110 + + G +T+P G +S + LR+ LY +RP+ + + + + Sbjct: 62 IILFGAITSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIADYEFLNAKN 121 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+VI REN+ED+Y G E R I + + +G+ Sbjct: 122 IDIVIIRENTEDLYVGRE------------------------RLENDTAIAERVITRKGS 157 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 +R++R A EYAI N+R V+ +HK N+++ T+G F + ++ + Sbjct: 158 ERIIRFAFEYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY 203 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 185 bits (471), Expect = 6e-46, Method: Composition-based stats. Identities = 48/221 (21%), Positives = 94/221 (42%), Gaps = 43/221 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + V+ +K I + I ++S+ + ++ Sbjct: 98 IGPEMARHVKTVL-------HKCGAPIDFEVIDIKDESS---------TDAAIISLKRNG 141 Query: 61 VAIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + +KG +TT + +S+N +R++LDLY + P + G D+V+ REN Sbjct: 142 IGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGV---WTRHGQVDLVVIREN 198 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y +E + E +K +E+ ++R+ + A + Sbjct: 199 TEGEYGSLEHENVDGVVE-----------------------SLKIITEKKSRRIAKFAFD 235 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 YA+ N+R VT +HK NIMK +G F + +++++ E Sbjct: 236 YALQNNRRKVTAIHKANIMKLADGLFLETCREISKDYTDIE 276 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 185 bits (470), Expect = 9e-46, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 84/225 (37%), Gaps = 27/225 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ +K Y + + +G+ +P LD+++ Y Sbjct: 14 IGPEVMNEALKVLRILKDKDYTFQFHADM--FLWNSEYYLQHGR--MMPENGLDILKNYD 69 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL-TDMVIF 116 + G + P + L + +R+ Y+ LRPV+ +G P H E + VI Sbjct: 70 AILFGAIGDPRVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFIHQERPINFVIV 129 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+ G + + + +GT+R+ R Sbjct: 130 RENAEGEYS-------------------NSGGRIYQGTDQEIAVQNTIITRKGTERIARY 170 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A +YA + V K N + + + + +A E +L Sbjct: 171 AFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQL 215 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 184 bits (468), Expect = 1e-45, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 89/222 (40%), Gaps = 35/222 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A+ + + + E+ + + E + I+ Sbjct: 61 IGPEMVVAVQDIFRHI-------GVPVDFEELNLSGLDIKDEDSYLGAFNEAITSIKRNG 113 Query: 61 VAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + TP+ G RSLN+ LR LDL+ + + G + D+VI R+ Sbjct: 114 VAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT---RHNNVDLVIIRQ 170 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+ +E + S E +K +EE ++ + A Sbjct: 171 NTEGEYSHLEHENVSGVIEN-----------------------LKVTTEEACMKIAQYAF 207 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 ++A +DR VT VHK NIMK +G F +++ E Sbjct: 208 DFAEKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIE 249 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 183 bits (464), Expect = 5e-45, Method: Composition-based stats. Identities = 47/230 (20%), Positives = 99/230 (43%), Gaps = 15/230 (6%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V KV+ AA E + W+++ G+ + +L + +YR Sbjct: 14 IGPEVIAEGRKVIAAAQEV---YNFDVEWIDMPFSADHYVKTGE--TISESSLKELSKYR 68 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE--LTDMV 114 G + G + + + +R D Y+ LRPV+ +G +P+K D Sbjct: 69 AIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKGKTAADIDFY 128 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLRE----EMGVKKIRFPEHCGIGIKPCSEEGT 170 + REN+ED Y GI ++ +++ ++ +R+ + G+ + + S+EG Sbjct: 129 VVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQLGVVSKEGA 188 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 KR++ + + A + + ++ V K N++ G +++ A + + Sbjct: 189 KRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVK 238 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 182 bits (462), Expect = 7e-45, Method: Composition-based stats. Identities = 54/224 (24%), Positives = 86/224 (38%), Gaps = 28/224 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + + AA+E ++ G + G +P + DL+++ Sbjct: 18 IGPEVVAATVPALRAALE---ADGHRLDVTSFDWGGERYLRQG--AAMPPDAADLVKKTD 72 Query: 61 VAIKGPLTTPVGGGI---RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P L + LRQ+LDL + LRPVR + G P+ V+ + D+VI R Sbjct: 73 AVLFGAVGRPDVPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDTDGVDLVIVR 132 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+E Y G GV GI + S +R A Sbjct: 133 ENTEGEYVGAG-------------------GVAHAGSGHDLGIEVAVHSRRAIERAAHQA 173 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A + LV K N M++ + ++ + G EL Sbjct: 174 FALAGRRS-GRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVEL 216 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 182 bits (462), Expect = 7e-45, Method: Composition-based stats. Identities = 51/224 (22%), Positives = 86/224 (38%), Gaps = 29/224 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V A KV+ A E G S+ +G+ +P + + + ++ Sbjct: 16 VGKEVVAAAEKVLHTAAEV--HGGLSFSFTAFPWSCDYYLEHGK--MMPEDGIHTLTQFE 71 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 G + P + L + +R+EL+L I +RP + G SP+ HP D V+ Sbjct: 72 AVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLLHPNDFDFVVI 131 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RENSE Y+ + + D + I + + T+R++R Sbjct: 132 RENSEGEYSEVGGRIHRGD--------------------DEIAIQNAVFTRKATERVMRF 171 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A E A R VT K N + + + Q A + G E Sbjct: 172 AFELAKKR-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIE 214 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 182 bits (462), Expect = 8e-45, Method: Composition-based stats. Identities = 56/220 (25%), Positives = 95/220 (43%), Gaps = 39/220 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + V+D + ++ G++ + +G LP ET+D++R+ Sbjct: 21 IGKEVMEATISVLDEL-------DVDFDYIYGIAGDECNEEHGTP--LPQETIDIVRDSD 71 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + V +RQE+ ++ LRPV+ Y T S E D +I REN+ Sbjct: 72 ACLFGAA----GETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF---ENVDFMIVRENT 124 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y + E I + + E +R++ A +Y Sbjct: 125 EGLYIA-----------------------DQEEETEDGAIAKRVITREAEERIIDYAFQY 161 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A N+R VT VHK N++K T+G FK Y++ + + Sbjct: 162 AKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDID 201 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 180 bits (458), Expect = 2e-44, Method: Composition-based stats. Identities = 51/214 (23%), Positives = 91/214 (42%), Gaps = 36/214 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ PA +KV+DA + + + G + G + L+ I+ Sbjct: 11 IGREIIPAAVKVLDA-------FGLEFEKVPLELGYTRWERTG--TAISNNDLETIKGCD 61 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G +TT +S+ + +R+ELDLY +RPV+ G + V D +I REN+ Sbjct: 62 AVLFGAITTVPDPNYKSVLLTIRKELDLYANVRPVKPLPGI-TGVTGRNDFDFIIVRENT 120 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+GIE + + +G++R+ A + Sbjct: 121 EGLYSGIE------------------------EIGPELSWTKRVVTRKGSERIAEYACKL 156 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 A ++ +T+VHK N++K ++ F D Q A Sbjct: 157 AKKR-KNKLTIVHKSNVLK-SDKLFLDVCRQTAS 188 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 180 bits (457), Expect = 3e-44, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 86/225 (38%), Gaps = 31/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVT A ++V+ AA + G + +G+ +P + ++ +R + Sbjct: 14 IGVDVTDAAMEVLGAAAK----GRFAFDTTSFPWSCEYYLEHGR--MMPEDGIETLRGFD 67 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 G + P + L + +R+ + Y +RP R G P+K E D++ Sbjct: 68 AIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK-AEGFDILCI 126 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+G + + + G +R++R Sbjct: 127 RENTEGEYSGAGGRVHEGK-------------------GNEVAVETSVFTRAGVERILRF 167 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 E A + R +T V K N K++ + + +LA E + Sbjct: 168 GFEQARSR-RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTV 211 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 180 bits (457), Expect = 3e-44, Method: Composition-based stats. Identities = 53/245 (21%), Positives = 85/245 (34%), Gaps = 50/245 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +++A E + EI G + +G W P + R Sbjct: 20 IGPEVMAQARDLLEAVAEP---SGVRFELDEIPCGGRFYLEHGARDW-PEDAEARCRGAD 75 Query: 61 VAIKGPLTTPVGGGI------------RSLNVALRQELDLYICLRPVRYYQGTPSPVK-- 106 V + G + P G S + R +LDLY +RPV+ G + Sbjct: 76 VILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGVAHRISGT 135 Query: 107 -----HPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 161 PE DMVI REN+E +YAG+ G ++ Sbjct: 136 RQQVWRPEHVDMVILRENTEGLYAGMG-------------------GQLRVGGSASVATD 176 Query: 162 IKPCSEEGTKRLVRAAIEYAIANDR-------DSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 + + G +R++R A E R VT + K N+++ F + ++A Sbjct: 177 TRLITRRGCERIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVAS 235 Query: 215 EEFGG 219 E Sbjct: 236 EYPDI 240 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 180 bits (457), Expect = 3e-44, Method: Composition-based stats. Identities = 58/223 (26%), Positives = 97/223 (43%), Gaps = 28/223 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ PA +K++DAAV A I+W E+ G + YG+ P +TLD + E Sbjct: 34 IGPEIVPASVKILDAAVAAAGAT--PIAWTELPLGRSAIDEYGEHT--PTKTLDALDEVD 89 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + GP + + + +R+ L+ +RP + ++G + V E TD+VI Sbjct: 90 GWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGGNAIV---EGTDLVIV 146 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA A + + I + T+R+ Sbjct: 147 RENTEGFYADRNTFAGTGEM----------------MPTPDVAIMHGIITRAATERIAHE 190 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A + A D VT+VHK N++K T G F+D ++ ++ Sbjct: 191 AFQLARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQYPDV 232 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 180 bits (457), Expect = 3e-44, Method: Composition-based stats. Identities = 51/233 (21%), Positives = 92/233 (39%), Gaps = 38/233 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +KV++ EK K+++ E + G + G LPAETL E Sbjct: 14 IGPEVMAEAMKVLNKVQEKF---GFKLNFNEFFVGGAAIDHCGYP--LPAETLKGCDEAD 68 Query: 61 VAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTP--SPVKH---P 108 + G + P + R + LR+ L+ LRP Y+G P++ Sbjct: 69 AILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCPLRADIAA 128 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 + DMV+ RE + IY G + ++ + + Sbjct: 129 KGFDMVVVRELTGGIYFGQPKGREGEGSQT-------------------KAFDTEVYYKY 169 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +R+ RAA E A+ + VT V K N+++ + +++ ++A++ L Sbjct: 170 EIERIARAAFEAAMKRN-KKVTSVDKANVLQ-SSILWRETVTEMAKDYPEVTL 220 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 180 bits (456), Expect = 3e-44, Method: Composition-based stats. Identities = 43/225 (19%), Positives = 81/225 (36%), Gaps = 30/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DVT A +V+ ++ + G +P + ++ +R + Sbjct: 14 IGQDVTDAAWQVLSTVARH---SGFTLTATPFPWSCAFYKETG--AMMPPDGIETLRRFD 68 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + G + P + L + +R+ Y +RP R G P+K E D++ Sbjct: 69 AILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLK-AEGFDILCI 127 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+G + A + + + G +R++R Sbjct: 128 RENTEGEYSGAGGRVHQGTA-------------------DEVAVETSIFTRTGVERILRF 168 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + A R + V K N K++ + + +LA E E+ Sbjct: 169 GFDQARQR-RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEV 212 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 180 bits (456), Expect = 4e-44, Method: Composition-based stats. Identities = 61/218 (27%), Positives = 96/218 (44%), Gaps = 37/218 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVWLPAETLDLIREY 59 IG + + A+ ++ A I + EI G + D E + ++ Sbjct: 31 IGRETSNAVTEIFKTA-------NVPIEFEEIDVTGMEKNNKSSGDAL--HEAIQSLKRN 81 Query: 60 RVAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 +V +KG L TP GG S NVALR+ELD+Y L ++ G + + D I RE Sbjct: 82 KVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT---RHDNVDFAIIRE 138 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E Y+G+E ++ E +K +E +KR+ + A Sbjct: 139 NTEGEYSGLEHQSVPGVVE-----------------------SLKIITEYKSKRIAQFAF 175 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 ++A+ N R SVT +HK NIMK +G F+ Y +A Sbjct: 176 DFALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGY 213 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 179 bits (455), Expect = 4e-44, Method: Composition-based stats. Identities = 59/220 (26%), Positives = 90/220 (40%), Gaps = 33/220 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A+L ++ A +S + G + P + I R Sbjct: 18 VGPEIMEAVLFILKEARA-------DVSIETVDIGHNQYKKEWTSGIAP-SAWESISRTR 69 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + +K P TP G G +SLNVALRQ L LY+ +RP Y P D+VI REN Sbjct: 70 LLLKAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCVSY--FPVVGTKHPDLDVVIIRENE 127 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED Y+G+E + E +K + ++++ A Y Sbjct: 128 EDTYSGVEH-----------------------KLSEDTHECVKISTRSASEKICAYAFNY 164 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A A++R VT K NIMK T+G ++A+ E Sbjct: 165 ARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIE 204 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 179 bits (454), Expect = 6e-44, Method: Composition-based stats. Identities = 47/205 (22%), Positives = 83/205 (40%), Gaps = 29/205 (14%) Query: 16 AVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI 75 VE + + E Y + + + + + A+KG T +G Sbjct: 64 IVEVFQNSGVPVDFEECYITGDTNEEKMKSF---NDIKTSVLRNGTALKGNWATSMGIDS 120 Query: 76 RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSAD 135 +S NV LR +LDLY + + Y + + D+++ REN+E Y +E + Sbjct: 121 KSYNVLLRHDLDLYANVVKFKSYP---TVITRHNNVDLIVIRENTEGEYTNLEHENIPGV 177 Query: 136 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKG 195 E IK +++ ++R+ + A +YA+ N+R VT VHK Sbjct: 178 IEM-----------------------IKIITKKKSERIAKYAFDYAMENNRKKVTAVHKA 214 Query: 196 NIMKFTEGAFKDWGYQLAREEFGGE 220 NIMK ++G F ++A + Sbjct: 215 NIMKLSDGLFLKVCKEVAEGYPEID 239 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 179 bits (454), Expect = 6e-44, Method: Composition-based stats. Identities = 59/232 (25%), Positives = 91/232 (39%), Gaps = 42/232 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + V+ A + G + Q G+ LP+ TL R Sbjct: 16 IGREVIPAAVAVLRA-------TGLPFHFENADAGWECFQRQGE--ALPSATLTAARAAD 66 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 + G + +P G RS V LR+ELDLY +RPV D+V+ RE Sbjct: 67 AILFGAVASPGYPVAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRRRKVDLVVVRE 126 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+ED+YAG E D I + + + R++R A Sbjct: 127 NTEDVYAGRERVEDDGA----------------------TAIAERVITRRASARIMRVAC 164 Query: 179 EYAIAN---------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + A A VT+VHK N+++ T G F+ ++A+ ++ Sbjct: 165 DLARARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQI 216 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 179 bits (454), Expect = 7e-44, Method: Composition-based stats. Identities = 53/221 (23%), Positives = 87/221 (39%), Gaps = 39/221 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + + + I + + + + I+ Sbjct: 67 IGPECMGYVRDIFKYI-------GAPIDFEVVDI-----DPTMDNDDDVQYAITTIKRNG 114 Query: 61 VAIKGPLTTPVGGGI-RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 V +KG + T S NVALR ELD+Y + + Y G + + D+VI R+N Sbjct: 115 VGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT---RHKDIDVVIIRQN 171 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E YA +E ++ + E +K + + ++R+ R A E Sbjct: 172 TEGEYAMLEHESVNGVVE-----------------------SMKVVTADNSERVARFAFE 208 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 +A N R VT VHK NIMK ++G F + +LA+E E Sbjct: 209 FAKKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIE 249 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 179 bits (454), Expect = 7e-44, Method: Composition-based stats. Identities = 48/233 (20%), Positives = 80/233 (34%), Gaps = 38/233 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V KV++ K + +I+ + G + +G LP T+ E Sbjct: 12 IGPEVMVEAKKVLNTVASKF---DFEITTQDYDIGGAAIDNHGN--ALPDSTMAGCIESD 66 Query: 61 VAIKGPLTTPVGGGI-------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT-- 111 + G + P + R + LR DL+ +RP S Sbjct: 67 AILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLRSDISE 126 Query: 112 ---DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D+++ RE + DIY G E ++ E G S Sbjct: 127 QGFDVLVIRELTGDIYFG-------------------EPKGRRGEGEEETGFDSMFYSRR 167 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 KR+ A + A + + VT V K N++ T ++ ++A E EL Sbjct: 168 EVKRISHLAFQAAQKRN-NKVTSVDKANVL-ATSQLWRQVVEEVAVEYPDVEL 218 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 179 bits (453), Expect = 8e-44, Method: Composition-based stats. Identities = 57/228 (25%), Positives = 84/228 (36%), Gaps = 32/228 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V L+V+ AV + + + G GQ L L + ++ Sbjct: 15 IGPEVVHEALRVLREAV----PADVSLDTTQYPFGAGHFLETGQ--ILTDSDLAALAQHD 68 Query: 61 VAIKGPLT-TPVGGGI------RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDM 113 + G + P + R L + LR D YI LRP G SP+ P D Sbjct: 69 AILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVASPLAAPGQVDF 128 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 V+ RE +E YAG GV + + + G +R Sbjct: 129 VVVREGTEGPYAG-------------------NGGVLRRGTEHEIATEVSVNTAHGVERT 169 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 VR A E A DR VTLVHK N++ F ++ ++A E + Sbjct: 170 VRFAFELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTV 217 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 178 bits (451), Expect = 1e-43, Method: Composition-based stats. Identities = 52/225 (23%), Positives = 87/225 (38%), Gaps = 26/225 (11%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A ++V+ +A + +++ G S + YG L E L + Y Sbjct: 11 IGPEIVGAAMEVLRSADSVF---KLDLAFDYDDVGFTSLEKYG--TTLRDEVLAKAKTYD 65 Query: 61 VAIKG---PLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 I G P G R+++ R LDLY +RP R S ++ D+VI Sbjct: 66 GVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRTMDLVIM 125 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RE +E Y A+ + I ++ + ++R+ R Sbjct: 126 REATEGFYPDRNMTKGWAE----------------LMPSPDMAISLRKITRHCSERIARR 169 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A E A+ + VT +HK N T+G F + +AR+ L Sbjct: 170 AFELAMKR-KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRL 213 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 178 bits (451), Expect = 1e-43, Method: Composition-based stats. Identities = 54/222 (24%), Positives = 88/222 (39%), Gaps = 28/222 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ P ++V+ AA + I W +I G + G LP T++ + Sbjct: 11 IGHEIVPEAVRVMQAAAAR---TGLAIEWQDIPIGRAALDSLG--STLPDGTIERLDALD 65 Query: 61 VAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + GP+ P + + LR+ DL+ +RPV+ + P + D+VI R Sbjct: 66 GWLLGPIGHMAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL---HQGVDLVIVR 122 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+E A S + R I ++ + G+ ++ RAA Sbjct: 123 ENNEGFQPDRNVVAGSGE----------------FRPTPDVTISVRVITRNGSSKVARAA 166 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 E A A R +T VHK + K G F + +LA E Sbjct: 167 FELARAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDV 207 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 177 bits (449), Expect = 3e-43, Method: Composition-based stats. Identities = 51/222 (22%), Positives = 90/222 (40%), Gaps = 39/222 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + + G+ + + I G + + IR Sbjct: 58 IGPEMMRHVEAIF-------ACGKVPVDFETIIVDA----NVGDASSM-DHAIKSIRRNG 105 Query: 61 VAIKGPL-TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 VA+KG + TT + N+ LR +L+LY+ + R + G + + D+V+ R+N Sbjct: 106 VALKGNIETTSYSMTVEPRNLLLRNKLELYVNVVHCRNHPGINT---KHKGVDIVVIRQN 162 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y+ +E + S E +K + + ++ + E Sbjct: 163 TEGEYSCLEHEVTSGVVE-----------------------SLKIITWAKSFQIAKYCFE 199 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 YA + R VT+VHK NIMK T+G F ++A+E EL Sbjct: 200 YARTHMRKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIEL 241 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 177 bits (448), Expect = 3e-43, Method: Composition-based stats. Identities = 43/226 (19%), Positives = 82/226 (36%), Gaps = 31/226 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVWLPAETLDLIREY 59 IG++V P ++V++AA K + + +G+ +P + + +++Y Sbjct: 16 IGLEVLPEGIRVLEAAALK---HGLALEFDTFEWASCDYYLQHGK--MMPDDWAEQLKQY 70 Query: 60 RVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDM 113 G + P + + R+E D Y+ +RPVR + G P + + D Sbjct: 71 DAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRKVGDIDF 130 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 V+ REN+E Y+ + G+ I + G R+ Sbjct: 131 VVVRENTEGEYSSLG-------------------GIMFENTENEIVIQESIFTRRGVDRI 171 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 ++ A + A +R VT K N M + + +A Sbjct: 172 LKYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHV 217 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 176 bits (446), Expect = 6e-43, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 92/222 (41%), Gaps = 38/222 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A+ +V AA E +S ++ E+ + L ++E + Sbjct: 59 VGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL----------EQVLSSMKENK 108 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VAI G + TP G + S ++ LR++LDL+ + V+ G + D+VI RE Sbjct: 109 VAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGY---MTRHNNLDLVIIRE 165 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 +E Y+ +E ++ E +K + ++R+ + A Sbjct: 166 QTEGEYSSLEHESARGVIE-----------------------CLKIVTRAKSQRIAKFAF 202 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 +YA R VT VHK NIMK +G F ++A + Sbjct: 203 DYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIK 244 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 176 bits (446), Expect = 6e-43, Method: Composition-based stats. Identities = 54/226 (23%), Positives = 92/226 (40%), Gaps = 34/226 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V K +DA E I+W ++ G +G +PA+ +D++R + Sbjct: 11 VGPEVMAEARKALDAL-------ELGIAWTDVPWGSAWWAEHG--TMMPADAIDVLRGHD 61 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMVI 115 + G + P + L + +RQELDL++ +RP R +G P P+ + P DMV Sbjct: 62 AILMGAVGDPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAPHDVDMVF 121 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RENSE YAG+ + F I + G +R++R Sbjct: 122 VRENSEGEYAGVGGRVHRG-------------------FGHDVAIESSVFTRRGCERVIR 162 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A A A + + K N +F + + ++ E G + Sbjct: 163 YAFGMASAR-KGVLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVV 207 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 175 bits (445), Expect = 7e-43, Method: Composition-based stats. Identities = 52/223 (23%), Positives = 102/223 (45%), Gaps = 41/223 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++T ++ + +A I W I + + + V+ E ++ ++ + Sbjct: 39 VGKEITDSVRTIFEA-------ENIPIDWETINIKQT---DHKEGVY---EAVESLKRNK 85 Query: 61 VAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + +KG TP G SLNVALR++LD+Y + + +G + + D+++ REN Sbjct: 86 IGLKGLWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP---DIDLIVIREN 142 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E ++G+E ++ E +K + T+R+ R A + Sbjct: 143 TEGEFSGLEHESVPGVVE-----------------------SLKVMTRPKTERIARFAFD 179 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLA-REEFGGEL 221 +A +R SVT VHK NIMK +G F++ ++ +E ++ Sbjct: 180 FAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDV 222 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 175 bits (445), Expect = 7e-43, Method: Composition-based stats. Identities = 54/222 (24%), Positives = 92/222 (41%), Gaps = 33/222 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGV+V K+ + I + G + G+ +P + +D +++Y Sbjct: 21 IGVEVMSEAEKMFQSL-------NLPIQRDYVDWGIQHYLKTGK--VVPIDYIDQVKQYD 71 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G L P + +RQ+LD ++CLRP +++ G P+P+K E D+++ R Sbjct: 72 AILLGSLGDPRTLPDYVTLEPLIQMRQQLDQFLCLRPAKHFPGIPTPLKKCE-IDILVVR 130 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 ENSE Y+ I G+ K P+ I + G +R++R A Sbjct: 131 ENSEGEYSNIG-------------------GIFKSGTPDEFAIESAVHTRRGLERVIRYA 171 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 E + R+ VTL K N MK+ + +A E Sbjct: 172 FEASRKR-RNHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDV 212 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 175 bits (443), Expect = 1e-42, Method: Composition-based stats. Identities = 54/229 (23%), Positives = 106/229 (46%), Gaps = 38/229 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKG---ERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR 57 IG +V PA ++V++AA+ K K + + ++ + G ++ Q G+ LP ET++ ++ Sbjct: 42 IGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKS--LPVETVEALK 99 Query: 58 -EYRVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 + AI G + +P G S VA+R+ +DLY +RP + + DM+ Sbjct: 100 NKCDGAIFGSVQSPSHKVEGYSSPIVAMRKLVDLYANIRPCQDL---------AKGIDML 150 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 I REN+E +Y E E + + +E +KR+ Sbjct: 151 IVRENTECLYIKKEKLTVDPT------------------TGEKTAVADRLITERASKRIA 192 Query: 175 RAAIEYAIANDR---DSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + A+ ++ VT+VHK N++ ++G F++ +++++ + Sbjct: 193 EIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVK 241 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 174 bits (442), Expect = 2e-42, Method: Composition-based stats. Identities = 44/225 (19%), Positives = 83/225 (36%), Gaps = 30/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG DVT A V++ + A G + G +PA+ ++ ++ + Sbjct: 14 IGRDVTDAAWAVLE---KTAGSGGFSLEATRYPWSCDYYLENG--SMMPADGIETLKSFD 68 Query: 61 VAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + G + P + L + +R+ Y +RP R G P++ + D++ Sbjct: 69 AILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPLRS-DGFDILCI 127 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+G + I + +G +R++R Sbjct: 128 RENTEGEYSGAGGRIHQGA-------------------DNEVAIETAIFTRKGVERILRF 168 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 E A A R + V K N K++ + + + L+ E E+ Sbjct: 169 GFEQARAR-RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEV 212 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 172 bits (436), Expect = 7e-42, Method: Composition-based stats. Identities = 51/225 (22%), Positives = 95/225 (42%), Gaps = 29/225 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++V++AA ++ + + G S Q +G + L+ ++ Sbjct: 11 IGPEIMAVAVRVLEAASKRF---QLDLEIGHDIAGHASLQRHG--ATVTPALLEKVKAAD 65 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + GP+ T G + + R+ELDLY +RP R + G V ++ + Sbjct: 66 GLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAHRV---GEFNLAVV 122 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA ++ S++ I ++ + +R+ R+ Sbjct: 123 RENTEGFYADRNIESGSSEML----------------ITPDTVISLRRITRLCCERIARS 166 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A + A R V++VHK N++K +G F D Q+ARE + Sbjct: 167 AFDLARTRAR-HVSIVHKANVLKIGDGMFVDICRQVAREFPQVRV 210 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 172 bits (435), Expect = 9e-42, Method: Composition-based stats. Identities = 54/233 (23%), Positives = 89/233 (38%), Gaps = 42/233 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV++ +K + + + G + +G+ LP ET + E Sbjct: 11 IGPEVVREALKVLEVVEKK---TGKTFEKVFGHIGGDAIDRFGEP--LPEETKKICLEAD 65 Query: 61 VAIKGPLTTPVGGGIR-------SLNVALRQELDLYICLRPVRYYQGTP--SPVKHP--- 108 G + P + +ALR+ L+LY +RP++ Y+ SP+K Sbjct: 66 AIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLKEKVIG 125 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D+V RE S +Y G + E G + Sbjct: 126 SGVDLVTVRELSYGVYYG-----------------------QPRGLDEEKGFDTMIYDRK 162 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +R+ R A E A N R VT V K N++ ++ ++ ++ARE EL Sbjct: 163 TVERIARTAFEIA-KNRRKKVTSVDKANVL-YSSMLWRKVVNEVAREYPDVEL 213 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 171 bits (434), Expect = 1e-41, Method: Composition-based stats. Identities = 57/224 (25%), Positives = 91/224 (40%), Gaps = 45/224 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A + ++A I W ++ G ++ Q G V++ +D E Sbjct: 44 IGREIVSAAKECIEA-------TGVNIRWEQMDMGYEAMQNTG--VYIDDSHMDAFEEIG 94 Query: 61 VAIKGPLTTPV----------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPEL 110 V KGPLT P G S N R+ L+ +RPVR G +P Sbjct: 95 VLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVRAPF---ND 151 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+V+ REN+ED+Y G E D+ +K S + Sbjct: 152 VDLVVIRENTEDVYTGEETWVDA-----------------------DTVHCVKRISRGAS 188 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 +R+ + +YA N R VT +HK N+ K ++G F + ++ A Sbjct: 189 ERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERAA 232 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 171 bits (434), Expect = 1e-41, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 82/222 (36%), Gaps = 33/222 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDVT +KV+D+A +I W E + G +P + + + Sbjct: 15 IGVDVTREAVKVMDSA------TGGRIEWTEFDYSCERYAKTG--AMMPPDAPTTLAGFD 66 Query: 61 VAIKGPLT---TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 + G + P + L + LR+ + Y+ LRPVR G SP+ E MVI Sbjct: 67 AILLGAVGYPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLAGVSDEALSMVI 126 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E Y+ I GV + + G +R++R Sbjct: 127 VRENTEGEYSPIG-------------------GVHNRGNQNEFALQESVFTRIGCERIIR 167 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A E A + V K N + + + ++A E Sbjct: 168 YAFELAASAGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEYP 208 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 171 bits (433), Expect = 2e-41, Method: Composition-based stats. Identities = 54/218 (24%), Positives = 89/218 (40%), Gaps = 38/218 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + K+ A + + E K T + I+ Sbjct: 55 IGPEMLDIVQKIFTFA-------NVPVDFEECQLDSKPT----SPESDLDNAIMSIQRNG 103 Query: 61 VAIKGPLTTPVGGG-IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 VAIKG + T +S NV LR+ LDL+ + P+ + ++V+ REN Sbjct: 104 VAIKGNIETKYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPT---RHKGINIVMIREN 160 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y+G E + + E +K C+ E +R+ R A + Sbjct: 161 TEGEYSGHEHETVNGVVE-----------------------SLKICTREKLERISRFAFD 197 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 YAIA++R +T VHK NI K +G F ++A +E+ Sbjct: 198 YAIAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEY 235 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 170 bits (432), Expect = 2e-41, Method: Composition-based stats. Identities = 65/209 (31%), Positives = 98/209 (46%), Gaps = 13/209 (6%) Query: 11 KVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP 70 +V +A I+W + G + Q LP D+IR + A+ GPL P Sbjct: 16 QVTNALQMAIAATGVDITWQIVDIGGE-----DQQGLLPNYIFDIIRTAKTAVIGPLMMP 70 Query: 71 VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWK 130 R + +R++LDLY+ LRP + G PS + D++I RE +E IYAGIE++ Sbjct: 71 --DNYRQMEADIREKLDLYVNLRPAKTMVGIPSNY---QNVDIMIVRETTEGIYAGIEFE 125 Query: 131 ADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVT 190 S +A FL + G R E +GIKP S +G +++ A YA R V Sbjct: 126 RTSVEAADARSFLSKLSG---KRIREDAAVGIKPISVKGCGQIIEFAFNYARKTKRHQVI 182 Query: 191 LVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 VH+ + M T+G F + +A+E Sbjct: 183 AVHQAHFMAHTDGLFLEIARDIAQEFPDI 211 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 170 bits (432), Expect = 2e-41, Method: Composition-based stats. Identities = 54/224 (24%), Positives = 84/224 (37%), Gaps = 30/224 (13%) Query: 3 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLI-REYRV 61 V +++ E+A I E+ G G P + I RE Sbjct: 19 PSVIAEAKLLLELYQERA---GLPIDLWELDLGADRYLRDG--TTFPNQIQIAIQRECSA 73 Query: 62 AIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVIF 116 + G L P R + +R DLY +RPVR P+K + D V+F Sbjct: 74 VLLGALGDPRVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVF 133 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E IY G+ G K P+ I + +G +R++RA Sbjct: 134 RENTEGIYVGMG-------------------GQFKRGTPDEVAINEDVNTRKGVERIIRA 174 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A +YA AN R VT+ K N M+ + +++ + + Sbjct: 175 AFDYARANGRTRVTMADKSNAMRHAHELWLRVFHEVRAQYPEIQ 218 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 170 bits (431), Expect = 3e-41, Method: Composition-based stats. Identities = 48/230 (20%), Positives = 97/230 (42%), Gaps = 38/230 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +K +++ + + + S+ + G K+ + +G +P ET+D + Sbjct: 13 IGPEVIKQAIKALNSIGNRFH---HEFSYQNVLAGAKAIETFGDP--MPKETIDSCLKSD 67 Query: 61 VAIKGPLTTPVGGGI------RSLNVALRQELDLYICLRPVRYYQGT-PSPVKHP--ELT 111 + G + P + LR+E+DLY +RP+ Y G SP+K E Sbjct: 68 AVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSPIKERKLEGV 127 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 + VI+RE + IY G + ++ + SE+ + Sbjct: 128 NFVIYRELTGGIYFGKKGRSKNGK----------------------EAYDYCVYSEKEIE 165 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ + + A + +R +TLV K N+++ T +++ ++A + +L Sbjct: 166 RIGEMSFKAARSRNRK-MTLVDKANVLE-TSRLWREVIQKMALDYSDVDL 213 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 170 bits (431), Expect = 3e-41, Method: Composition-based stats. Identities = 48/231 (20%), Positives = 86/231 (37%), Gaps = 36/231 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T + ++V++ EK +S+ G + +G LP +T++ + Sbjct: 13 IGKEITDSAVEVLEKVDEKF---GLGLSYTYKDAGGTAYDKFGTP--LPDDTIEACKASD 67 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTP--SPVKHP--EL 110 + G + + LR+ L LY LRPV+ SP+K + Sbjct: 68 GVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPLKPELVKG 127 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+VI RE IY G + +++ + ++ S Sbjct: 128 VDLVIVRELIGGIYFGDKCESEQHNGA-------------------ERAWDLENYSVPEV 168 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ + A E A R VT V K N++ T ++ ++A EL Sbjct: 169 DRIAKLAFETAKLR-RGKVTSVDKANVL-ATSRLWRRTVAKVAESYPDVEL 217 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 170 bits (430), Expect = 4e-41, Method: Composition-based stats. Identities = 44/224 (19%), Positives = 91/224 (40%), Gaps = 28/224 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A + V+ AA+ K Y + + + E G S + + +E L + + Sbjct: 14 IGPEIAKASVDVLQAAL-KLYDLKVNLVYEE--IGFASLKKH--KTTFRSEVLKIAEKCD 68 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 I G + P G + + +R+ DLY +RP + + P D ++ Sbjct: 69 GMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKN--RLGKLERFPMGIDCLVM 126 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E Y+ + + I I+ + +G+ R+ Sbjct: 127 RENTEGFYSDRNMFKGVGE----------------LMPTPDVAISIRNITRKGSTRIAEI 170 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 +YA+ R + +HK N++++++G F + Q++++ E Sbjct: 171 GFKYAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVE 213 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 170 bits (430), Expect = 4e-41, Method: Composition-based stats. Identities = 45/194 (23%), Positives = 78/194 (40%), Gaps = 34/194 (17%) Query: 28 SWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTP--VGGGIRSLNVALRQE 85 + E++ + + ++ + IR RVA+KG + T + +S N LR Sbjct: 1 DFEEVHVSSNADEEDIRNAIM------AIRRNRVALKGNIETNHNLPPSHKSRNNILRTS 54 Query: 86 LDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE 145 LDLY + + G V + D++I REN+E Y+ +E ++ + E Sbjct: 55 LDLYANVIHWKSLPGV---VTRHKDIDILIVRENTEGEYSSLEHESVAGVVE-------- 103 Query: 146 EMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF 205 +K ++ + R+ A + A + R VT VHK NIMK +G F Sbjct: 104 ---------------SLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLF 148 Query: 206 KDWGYQLAREEFGG 219 ++A Sbjct: 149 LQCCREVAARYPQI 162 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 169 bits (429), Expect = 5e-41, Method: Composition-based stats. Identities = 47/231 (20%), Positives = 80/231 (34%), Gaps = 35/231 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V V+ A + + E+ G + + G V LP ETL + ++ Sbjct: 154 IGPEVISVAKNVLKLAGSL---EGIEFGFQEMPVGGCALDLTG--VPLPEETLLVAKQSD 208 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGT--PSPVKH--PEL 110 + G + + + LR L ++ LRP S +K E Sbjct: 209 AVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDASTLKKEVAEG 268 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+++ RE + IY G + G K E G + + Sbjct: 269 VDLMVVRELTGGIYFG------------------KPRGFSKNENGEEIGFNTEVYATYEI 310 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ R A E A R + V K N+++ + ++ +A E EL Sbjct: 311 DRIARIAFETAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVEL 359 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 169 bits (429), Expect = 5e-41, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 84/234 (35%), Gaps = 31/234 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++V A L V+ A + G + + G+ +PA T +++ Sbjct: 18 IGIEVMEAALPVIAAL-------NLPFDLVPADIGWQCWRAEGE--TVPARTWEIMASCD 68 Query: 61 VAIKGPLTTPVGGGIR---------------SLNVALRQELDLYICLRPVRYYQGTPSPV 105 + G +T+ S + LRQ LDLY +RPV G Sbjct: 69 ATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVTDMTG----- 123 Query: 106 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 V+ REN+E +YAG+++ +++ + + + ++ Sbjct: 124 --ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREGQDDATVTLRLQ 181 Query: 166 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 + G R+ A EYA N VT V K +++ + + A+ Sbjct: 182 TRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQRYPDV 235 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 169 bits (428), Expect = 6e-41, Method: Composition-based stats. Identities = 55/223 (24%), Positives = 93/223 (41%), Gaps = 39/223 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA +V++A + ++E G ++ + G V P ET++ I Sbjct: 13 IGHEVIPAARRVLEA-------TGLPLEFVEAEAGWETFERRGTSV--PEETVEKILSCH 63 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 + G T+P G LR+ LDLY +RP + P P P D+VI RE Sbjct: 64 ATLFGAATSPTRKVPGFFGAIRYLRRRLDLYANVRPAKS---RPVPGSRP-GVDLVIVRE 119 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E +Y E + I S++ ++R+ RAA+ Sbjct: 120 NTEGLYVEQERRY------------------------LDVAIADAVISKKASERIGRAAL 155 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A R ++ + HK N++ T+G F D ++A++ + Sbjct: 156 RIAEGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNV 198 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 169 bits (427), Expect = 9e-41, Method: Composition-based stats. Identities = 56/226 (24%), Positives = 89/226 (39%), Gaps = 29/226 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ A + + E G + G+ LP + +R++ Sbjct: 16 IGPEVVAEGLKVLSAVAPR---HGLTLDTTEYELGAQRWHATGE--VLPDAVEEELRQHD 70 Query: 61 VAIKGPLTTPV---GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMVI 115 + G + P G R L + LR Y+ LRPVR Y G +P+ PE DM++ Sbjct: 71 AILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVAPEDIDMLV 130 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 RE +E YAG+ GV + P + G +R+VR Sbjct: 131 VREGTEGPYAGMG-------------------GVLRKGTPHEIATQDSVNTRLGVERVVR 171 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A A +TLVHK N++ + ++ ++ E E+ Sbjct: 172 YAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEV 217 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 167 bits (423), Expect = 2e-40, Method: Composition-based stats. Identities = 43/226 (19%), Positives = 80/226 (35%), Gaps = 32/226 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVWLPAETLDLIREY 59 IGV+V P L+ +DA + + ++ I +GQ +P + + Sbjct: 51 IGVEVMPEGLRALDAVSRRF---GLRFAYEPIEWASCDYYAKHGQ--MMPDDWKTQLSGM 105 Query: 60 RVAIKGPLT----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDM 113 + G + P + + R+E D Y+ LRP R + G P P+ + D Sbjct: 106 DALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGRKAGDIDF 165 Query: 114 VIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 +I REN+E Y+ + G + + GT+R+ Sbjct: 166 MIVRENTEGEYSAVG-------------------GTMFEGTEREFVVQQAVFTRHGTERV 206 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 ++ A E A +T+ K N + + + ++A Sbjct: 207 LKFAFELAQRRA-KRLTVATKSNGIAISMPWWDARAAEMAARYPDV 251 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 167 bits (423), Expect = 2e-40, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 103/244 (42%), Gaps = 33/244 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG V P ++V++A + +++ G + + LP T+ L+R+++ Sbjct: 14 IGNQVLPQAIRVLEAV-------GFEANYVHADIGWECW--CNEGNALPDRTIQLLRKHK 64 Query: 61 VAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVRYYQGTP--- 102 + + G +T+ G S V +RQ +L +C+RP + G P Sbjct: 65 LGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPGNPLNF 124 Query: 103 -----SPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEH 157 D+V+FR+N+E +YAG+EW + + ++ E Sbjct: 125 IRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFANTP-GEE 183 Query: 158 CGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 + ++ +++ +R+ AA ++A +VT+ K N+++ T G ++ Q+ ++ Sbjct: 184 LAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQVQKQYP 243 Query: 218 GGEL 221 L Sbjct: 244 EIAL 247 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 167 bits (422), Expect = 3e-40, Method: Composition-based stats. Identities = 52/228 (22%), Positives = 87/228 (38%), Gaps = 36/228 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA L++V+AA G +++ G + G LPA TLD R+ Sbjct: 18 IGREVMPACLELVNAA--TTMAGAPALAFQTHNAGAQYYAESGD--ALPASTLDACRKSD 73 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDMV 114 + G + P G + LR EL L+ +RP+R++ G P + P E D V Sbjct: 74 AILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPRAEQIDFV 133 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE +E ++ + + + GT+R+ Sbjct: 134 LVREQTEGLFYARG---------------------RGEIRNDEEAYDTMQITRSGTQRVT 172 Query: 175 RAAIEYAIANDRD----SVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 A + A R +VT V K N+ + + F+ ++A Sbjct: 173 EFAFDIARQRKRRGKPGNVTCVDKANVFQ-SMAFFRKVFDEVADRHSD 219 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 166 bits (420), Expect = 5e-40, Method: Composition-based stats. Identities = 51/222 (22%), Positives = 88/222 (39%), Gaps = 38/222 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ L+V+ AA +S G E L IR R Sbjct: 48 IGPEIMDHTLRVLKAAGAPLSYEIFALS-----------SKDGSKNNDFDEALTSIRRNR 96 Query: 61 VAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 VA+KG + I+S N+ R+ LDL++ + + + G D+ + R+N Sbjct: 97 VALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLS---NKFGEIDITVIRQN 153 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E Y +E + + E +K + +RL+ A + Sbjct: 154 TEGEYLMLEHEPRTGSVE-----------------------SLKVLTRFNLERLIEFAFD 190 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 YA+ NDR +T+VH NI K TEG F + ++++ ++ Sbjct: 191 YALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSYPMIKM 232 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 165 bits (418), Expect = 1e-39, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 75/233 (32%), Gaps = 38/233 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + T + K+++ ++ + I E G + G P TL + Sbjct: 15 IGPETTRQVYKILNVIKKQF---QINIVTTEHKIGGDAINSEGTP--FPKSTLKYCEQSN 69 Query: 61 VAIKGPLTTPVGGGIRS-------LNVALRQELDLYICLRPVRYYQGTP--SPVKH---P 108 + G + P ++ +ALR+ +L+ LRP+ SP+ P Sbjct: 70 AILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKELSPLNINMIP 129 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 D++ RE + IY G Sbjct: 130 NGIDIIFVRELTGGIYFGQPKGRSGTGL-------------------NEYAFDTAVYHRF 170 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +R+ A + A R V+ + K N++ T +++ LA+ EL Sbjct: 171 EIERIANIAFKLAQKR-RKRVSSIDKANVL-HTSMLWREVVSHLAKNYPDVEL 221 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 164 bits (416), Expect = 2e-39, Method: Composition-based stats. Identities = 65/223 (29%), Positives = 103/223 (46%), Gaps = 36/223 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +T ++++ ++ K+ + I G + + +PAE L ++E Sbjct: 52 IGPAITSQAQRILEYLLKDDILQG-KVEFKVID-GLTIERRAAEHAAIPAEVLKELKECH 109 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 V +KGP TTP + S NVA+R+ELDL+ +RPVR + + D + Sbjct: 110 VILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE---------QGIDWTFY 160 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E YA +G K I E G+ + G++R++RA Sbjct: 161 RENTEGAYA---------------------VGSKGIHVTEDLGVDFTVVTSGGSERIIRA 199 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A EYA AN + VT V K NI+K T+G F D ++A++ Sbjct: 200 AFEYAKANGKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDI 242 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 164 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 59/232 (25%), Positives = 98/232 (42%), Gaps = 47/232 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A ++V++A + W I +++ ++YG LP + + I++ + Sbjct: 11 IGPEITAATIRVIEA-------TGIQPEWDFIPIADEAVRLYGH--ALPPQVIQRIKDVK 61 Query: 61 VAIKGPL-------------TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH 107 IK PL T S+N A+R+EL+L++ RP+R Y G Sbjct: 62 FCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISG---R 118 Query: 108 PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSE 167 E DMVI RE +ED Y G E + A IK + Sbjct: 119 HEKMDMVIMREITEDTYIGWEKPLEDGAA----------------------AEAIKRVTR 156 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 + ++ + A EYA + R V+ +HK N++ T+G F ++AR Sbjct: 157 SASWKVSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDI 208 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 164 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 53/228 (23%), Positives = 92/228 (40%), Gaps = 17/228 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT +KV++AA + G + LP L+ + Sbjct: 14 IGPEVTAQAVKVMEAAGSLF---GFSLELTHYPYGAEHYLST--RQVLPDHALEEMEGLD 68 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P G R + + LR D Y +RPVR + TP P+ + V+ R Sbjct: 69 ALLLGAIGDPRVQPGILERGILLKLRFHFDQYANIRPVRSF--TPGPL---GSVNAVVIR 123 Query: 118 ENSEDIYAGIEWKADSADAEKV----IKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 EN+ED+Y GI D A + ++ + P+ + + + +G R Sbjct: 124 ENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQVAWHTLDGAARA 183 Query: 174 VRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + A + A+ + VTL K N ++ G F++ +Q+A + L Sbjct: 184 CQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 163 bits (412), Expect = 4e-39, Method: Composition-based stats. Identities = 40/227 (17%), Positives = 75/227 (33%), Gaps = 36/227 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V + +V+ + Y G + + GQ LP TL Sbjct: 13 VGPEVMESAKEVLHMVERL---YGHHFHLQDEYFGGVAIDLTGQP--LPQRTLAACLASD 67 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVR--YYQGTPSPVKHPELTDMV 114 + G + P + +ALR+ L ++ +RPV SP+K+ + D V Sbjct: 68 AVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNADEIDFV 127 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE + IY E +R+V Sbjct: 128 VVRELTGGIYF-----------------------SYPKERTEEVATDTLTYHRHEIERIV 164 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A + A + VT + K N+++ + ++ ++A E+ Sbjct: 165 SYAFQLANKR-KKKVTSIDKANVLE-SSKLWRTVTEEVALRYPNVEV 209 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 161 bits (408), Expect = 1e-38, Method: Composition-based stats. Identities = 49/229 (21%), Positives = 84/229 (36%), Gaps = 38/229 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ L+++ EK + + + G S YG L ETL + Sbjct: 13 IGPEILSGTLELLKLISEKYH---FEYHLESHHFGGVSIDYYGTP--LTNETLQSCKNAD 67 Query: 61 VAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTP--SPVKHP--ELTD 112 + G + P + LR+ L+L+ +RP +G SP+K E TD Sbjct: 68 AILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQDIVEGTD 127 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 +VI RE + IY G +A +K S + +R Sbjct: 128 LVIVRELTSGIYFGEPSYVKKTEALDSLK-----------------------YSSQEIER 164 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +VR A A R +T V K N++ + ++ + ++ E+ Sbjct: 165 IVRIAFNLANRR-RKKLTSVDKENVL-SSSKLWRQIVNDVKKDYPEVEV 211 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 161 bits (408), Expect = 1e-38, Method: Composition-based stats. Identities = 51/231 (22%), Positives = 85/231 (36%), Gaps = 40/231 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +VT A LKV+ A E +++ G + +G+ P T + E Sbjct: 11 IGPEVTEAALKVLRALDE---AEGLGLAYEVFPFGGAAIDAFGEP--FPEPTRKGVEEAE 65 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTP--SPVKH--PEL 110 + G + P G + ++LR+ DL+ LRP + + G SP+K Sbjct: 66 AVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKEEIARG 125 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + IY G + E + S+ Sbjct: 126 VDVLIVRELTGGIYFG-----------------------EPRGMSEAEAWNTERYSKPEV 162 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +R+ R A E A R V V K N+++ E ++ ++ R L Sbjct: 163 ERVARVAFEAARKR-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGYPDVAL 211 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 83/222 (37%), Gaps = 37/222 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA V++A K ++E G ++ + G V P TL+ + Sbjct: 15 IGHEVIPAARLVLEA-------TGLKFEFVEAQAGWETFERIGTSV--PEATLEAVTHTD 65 Query: 61 VAIKGPLTTPVG--GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 + G T+P G +R++LDL+ +RP +++ P P D+++ RE Sbjct: 66 ATLFGAATSPTKKVPGFFGAIRYMRRKLDLFANVRPAKHHP---VPGSRP-GVDLIVVRE 121 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAI 178 N+E +Y E I + + + R+ A Sbjct: 122 NTEGLYVEQERSYLEG----------------------EIAIADTVITRKASARIGEYAA 159 Query: 179 EYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + R + + HK N++ T+G F + A + Sbjct: 160 RLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVK 201 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 85/229 (37%), Gaps = 38/229 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ L +++ K Y +I E G S +G+ L +TL+ + Sbjct: 13 IGPEILNGSLSLLEIISNK-YNFNYQIEHHEF--GGASIDTFGEP--LTEKTLNACKRAD 67 Query: 61 VAIKGPLTTPVGGGI----RSLNVALRQELDLYICLRPVRYYQGTPSPVK----HPELTD 112 + G + P + LR+ L+L+ +RP +G S E TD Sbjct: 68 AILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKAERVEGTD 127 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 +VI RE + IY G ++ +A + + E +R Sbjct: 128 LVIVRELTSGIYFGEPRYFNNHEALDSLT-----------------------YTREEIER 164 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +V A + A + R +T V K N++ + ++ ++++ + Sbjct: 165 IVHVAFKLAASR-RGKLTSVDKENVL-ASSKLWRKVVNEVSQLYPEVTV 211 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 58/224 (25%), Positives = 88/224 (39%), Gaps = 31/224 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V LKV+ A + G Q G+ LP LD +R + Sbjct: 11 IGPEVVAEGLKVLRAVAP-------DVESTPYDLGASRWQRTGE--LLPDTVLDELRRHD 61 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P G R L + LR ELD ++ LRP R + G SP+ P DM+ R Sbjct: 62 AILLGAIGDPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAPGAIDMLCVR 121 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 E +E Y G GV + P + + G +R+VR A Sbjct: 122 EGTEGPYVG-------------------NGGVLRRDTPHEVATEVSLNTAFGVERVVRYA 162 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 E A+A R +TL+HK N++ + +++ E + Sbjct: 163 FERALARPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTV 206 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 160 bits (406), Expect = 2e-38, Method: Composition-based stats. Identities = 38/230 (16%), Positives = 85/230 (36%), Gaps = 42/230 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++V+ A EK K+++ G + G P ET + + Sbjct: 13 IGPEISVQGVEVMSAVCEKF---GHKVNYEYAICGADAIDKVGDP--FPEETYRVCKNAD 67 Query: 61 VAIKGPLTTPVGGG-------IRSLNVALRQELDLYICLRPVRYYQGT--PSPVKHP--E 109 + + P +A+R++L L+ +RPV+ ++ SP++ E Sbjct: 68 AVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPLRAELVE 127 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D + RE + +Y G +++ + Sbjct: 128 GADFLCIRELTGGMYFGEKYQ------------------------DNDKAYDTNMYTRPE 163 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 +R+++ EYA+ R +T+V K N++ + ++ ++A + Sbjct: 164 IERILKVGFEYAMKR-RKHLTVVDKANVL-ASSRLWRQIAQEMAPQYPEV 211 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 160 bits (405), Expect = 3e-38, Method: Composition-based stats. Identities = 44/216 (20%), Positives = 79/216 (36%), Gaps = 45/216 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T ++ V +A + + + ++ +R+ Sbjct: 43 IGPEITNSVKTVFEAL--------------HVPIKFDVLDNFNFEN---DDSKSQLRKNE 85 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G + T N + LDLY + +G + TD+V+ REN+ Sbjct: 86 CILLG-VMTEKNQKYTD-NYKFYKYLDLYSNITFAFSVEGIT---QRHNNTDIVVIRENT 140 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+G+E + E IK +++ + R+ A E+ Sbjct: 141 EGEYSGVEHEVYPGVVE-----------------------SIKVTTKQASLRIAEYAFEF 177 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + R VT VHK NIMK +G F ++A+ Sbjct: 178 AHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRY 213 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 49/231 (21%), Positives = 77/231 (33%), Gaps = 35/231 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V V+ A + + E+ G + + G V LP ET + Sbjct: 57 IGPEVISVAKNVLQKAGSL---EGLEFDFKEMPVGGAALDLVG--VPLPEETFTAAKLSD 111 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGT--PSPVKH--PEL 110 + G + LR++L ++ LRP S +K E Sbjct: 112 AILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEG 171 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 DM+I RE + IY G E G+ E G+ + + Sbjct: 172 VDMMIVRELTGGIYFG------------------EPRGITINENGEEVGVSTEIYAAHEI 213 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ R A E A R + V K N++ + ++ LA E EL Sbjct: 214 DRIARVAFETARKR-RGKLCSVDKANVLDAS-ILWRKRVTALASEYPDVEL 262 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 159 bits (401), Expect = 8e-38, Method: Composition-based stats. Identities = 56/221 (25%), Positives = 103/221 (46%), Gaps = 35/221 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIRE-Y 59 IG +V PA +V++ K +++++Y G ++ Q G+ LP ET+ +++E Sbjct: 34 IGKEVIPAGKQVLE---NLNSKHGLSFNFIDLYAGFQTFQETGK--ALPDETVKVLKEQC 88 Query: 60 RVAIKGPLTTPVGG--GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + A+ G + +P G S VALR+E+ L+ +RPV+ +G + + DMVI R Sbjct: 89 QGALFGAVQSPTTKVEGYSSPIVALRREMGLFANVRPVKSVEG-----EKGKPIDMVIVR 143 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+ED+Y IE K SE T+R+ A Sbjct: 144 ENTEDLYIKIEKTY------------------IDKATGTRVADATKRISEIATRRIATIA 185 Query: 178 IEYAIAN----DRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 ++ A+ + ++T+ HK N++ ++G F++ ++ Sbjct: 186 LDIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYE 226 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 159 bits (401), Expect = 9e-38, Method: Composition-based stats. Identities = 56/216 (25%), Positives = 91/216 (42%), Gaps = 40/216 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A L +++ ++EI G+ G+ + ++ IRE Sbjct: 11 VGPEIMGATLSLLE--------RYIGADFIEIKAGKSYFIEEGKP--IEDNAIEKIRECD 60 Query: 61 VAIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +KGP+ TP G S+N LR+E LY +RP R Y+G D ++ REN Sbjct: 61 SLLKGPVATPTKGPSYPSVNTLLRREFKLYANVRPFRSYEGISIR-----RIDTILVREN 115 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 E +Y G E + E I ++ ++ G +R+ A Sbjct: 116 LECLYYGWEVE------------------------DEDRAIAMRVITKRGAERISEFAFN 151 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A R VT +HK NI+K T+G F D Y++A + Sbjct: 152 LAKREGRGRVTAIHKRNILKRTDGLFLDAFYRVASK 187 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 158 bits (400), Expect = 1e-37, Method: Composition-based stats. Identities = 53/215 (24%), Positives = 85/215 (39%), Gaps = 38/215 (17%) Query: 15 AAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGG 74 + + + + G + + +G+D LP T D IRE +A+K L P G G Sbjct: 19 SVRRLFAAAKVPVEFEVHLAGRMALE-HGKD-ALPKATFDAIRECGLALKTKLLQPKGVG 76 Query: 75 ----------IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIY 124 + NVA R++L L+ +RPV G PS D ++FRE +ED+Y Sbjct: 77 MPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSRFT---GVDFLLFREITEDLY 133 Query: 125 AGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIAN 184 E + + K +E R + A + A Sbjct: 134 TASEHEIVPGVVQ-----------------------SFKIVTEAACLRFFKLAFDTARKR 170 Query: 185 DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 R +V +HK NI+K +G F + Y++A+E Sbjct: 171 GRKTVHCIHKANILKMADGLFLECFYRVAKEYPEI 205 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 158 bits (400), Expect = 1e-37, Method: Composition-based stats. Identities = 61/225 (27%), Positives = 92/225 (40%), Gaps = 36/225 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + L+V ++ K+ + I G + ++ LPAE L+ + Sbjct: 57 IGPCIMEQALRVAKYLLKDEMASG-KVEFRTIP-GMTIEERVQKNESLPAEVLEACKACD 114 Query: 61 VAIKGPLTTPVGGGIR----SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 V +KGP TP G S N LR+ L LY +RPVR + + D F Sbjct: 115 VLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE---------KGIDWTFF 165 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN E Y G K I+ + + K + G +R+ RA Sbjct: 166 RENIEGEYI---------------------WGNKGIQVDDDLAVDFKVLTRPGAERICRA 204 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A E+A N + +VT+V K NI+K +G F + L +E G + Sbjct: 205 AFEFAKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITV 249 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 157 bits (397), Expect = 2e-37, Method: Composition-based stats. Identities = 51/235 (21%), Positives = 87/235 (37%), Gaps = 42/235 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V+ A ++V+ +A I + + G + + G P T R+ Sbjct: 23 IGPEVSAATVRVL----TQALGTSFPIEFRDYDAGAECFRRTG--TAFPEATQVACRQAH 76 Query: 61 VAIKGPLTTPV---GGGIR---SLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTD 112 + G P G ++ +R LDLY +RP+R +G P + K P+ Sbjct: 77 AVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGKGPDDIR 136 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 I REN+E +YA + EG +R Sbjct: 137 FTIVRENTEGLYAARGG---------------------GNIIRGQIATDTLVMTREGVER 175 Query: 173 LVRAAIEYAI------ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +VR A E A A+ VT+V K N+++ + F++ + + G E+ Sbjct: 176 IVRYAAELARDGQGAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEV 229 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 157 bits (396), Expect = 4e-37, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 77/242 (31%), Gaps = 51/242 (21%) Query: 6 TPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 LKV+ A E + + ++ G + G W P++ + + G Sbjct: 1 MREGLKVLHAVSEPL---GIEWAIEDVPCGGQYYLEQGDLDW-PSDAPQKCDAADLILLG 56 Query: 66 PLTTPVGGGIRSLNV-------------ALRQELDLYICLRPVRYYQGTPSPVKH----- 107 + P G + R L+LY +RP++ Y G + Sbjct: 57 AVGWPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQI 116 Query: 108 --PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 DMVI REN+E +YA K I + Sbjct: 117 WEAGKVDMVIIRENTEGLYAPTGGKLAPGGKA-------------------DVAIDTRVI 157 Query: 166 SEEGTKRLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 + ++++R A E ++ VT + K N++ F+D +++ E Sbjct: 158 TRRACEQVIRHAFELCKRRNKGAPKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEYPE 216 Query: 219 GE 220 E Sbjct: 217 IE 218 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 61/232 (26%), Positives = 90/232 (38%), Gaps = 37/232 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ A ++V+DA E + R ++EI G + + G A+ L E Sbjct: 14 IGPEIVEATVRVLDALAE-LHPESRGWEYVEIDAGADTYRRTGVACA-EADVRRLRDEVD 71 Query: 61 VAIKGPLT-----TPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVI 115 +KGP+ TP G L LR LD Y +RPVR + G PS V + D VI Sbjct: 72 ATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSRV-RADRVDYVI 130 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E +YA + + EGT R+ R Sbjct: 131 VRENTEGLYASRGKGVGN----------------------RWAVTDTLLTTREGTLRVAR 168 Query: 176 AAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A A VT V K N+++ + F++ ++A E EL Sbjct: 169 KAFTLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVEL 219 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 156 bits (394), Expect = 5e-37, Method: Composition-based stats. Identities = 43/229 (18%), Positives = 77/229 (33%), Gaps = 35/229 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V + +++D + G G + V + T+ L + Sbjct: 14 IGTEVMAEVSRLIDWLNK---AGIASFETEHGLVGGAAYDA--DKVAITDATMALAQASD 68 Query: 61 VAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----EL 110 I G + P + + LR++L L+ LRP Y E Sbjct: 69 AVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEASSLKPEVVEG 128 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + +Y G E + + + I + Sbjct: 129 LDIMIVRELTGGVYFG------------------EPKTITDLGNGQKRAIDTQVYDTYEI 170 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 +R+ R A + A R+ VT + K N+MK T + + Q+ E+ Sbjct: 171 ERIGRVAFDLARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREYKD 217 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 156 bits (394), Expect = 5e-37, Method: Composition-based stats. Identities = 49/235 (20%), Positives = 83/235 (35%), Gaps = 34/235 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG++VT A L V + + + G + + G +P+ T LI Sbjct: 17 IGIEVTEATLPVFEVL-------DVPVILNYGDIGWEFWKKEG--AAIPSRTWQLIASSD 67 Query: 61 VAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 105 + G +T+ S + LRQ LDL+ +RP P Sbjct: 68 TVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDDQSKPF 127 Query: 106 KHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPC 165 + I RENSE +Y G ++ K I L E + + ++ Sbjct: 128 ------NFCIIRENSEGLYCGFDYFPLP----KAIHSLLAESQHWQTIPADEASCALRLQ 177 Query: 166 SEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 S+ G RL A ++A+ VTL K N+++ + + A+ + Sbjct: 178 SKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQ 232 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 156 bits (394), Expect = 6e-37, Method: Composition-based stats. Identities = 46/216 (21%), Positives = 88/216 (40%), Gaps = 38/216 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A++ V++ + + G+++ + G V LP ETL+ + Sbjct: 12 VGPEIIDAVIPVLETLSDLM---NLPLDLRFFEAGDETKRKRG--VALPEETLNGVMNSD 66 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + + G R + + LRQ+LDLY+ LRP + Y + D+ I REN+ Sbjct: 67 ATLMVAI----GESAREVILPLRQKLDLYVNLRPAKSYP----VPRAIPGFDLTIVRENT 118 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED+Y W+ + ++ + ++R+ R Y Sbjct: 119 EDLYVMSGWR------------------------GLDTAVDLRIITRRASERICRFGYRY 154 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 A + V +VHK N++ F++ ++A EE Sbjct: 155 ARERGKSRVYVVHKANVL-GGCMLFREVCSRVAEEE 189 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 155 bits (392), Expect = 9e-37, Method: Composition-based stats. Identities = 47/227 (20%), Positives = 88/227 (38%), Gaps = 33/227 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +++++ E ++ + GE Q G+ LP D Sbjct: 15 IGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGE--YQRSGE--ALPQSAYDACLASD 70 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKH--PELTDMV 114 + G + P G + + LR+ L LY +RP+R Y +P+K P D V Sbjct: 71 AVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPLKGHGPGEIDFV 130 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE++E ++ G + AD + + ++R+ Sbjct: 131 LVRESTEGLFYGRDAIADLEA---------------------DEATNLLRITRSASERVC 169 Query: 175 RAAIEYAIAN-DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 R A E A + +VTL+ K N++ + F+ ++A+E + Sbjct: 170 RLAFETARRRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFLDIK 215 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 154 bits (389), Expect = 2e-36, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 82/227 (36%), Gaps = 37/227 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++T +KV+ A + + K + G + G V LP E L+ ++ Sbjct: 15 VGQEITAEAIKVLKAISDV--RSNVKFDFENHLIGGAAIDATG--VPLPDEALEASKKAD 70 Query: 61 VAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRY-----YQGTPSPVKHPELT 111 + G + P G + +R+EL LY LRP + +P + + T Sbjct: 71 AVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFAKGT 130 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D V+ RE IY G + D + + + + Sbjct: 131 DFVVVRELVGGIYFGKRKEDD----------------------GDGVAWDSEQYTVPEVQ 168 Query: 172 RLVRAAIEYAIANDRD-SVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R+ R A A+ ++ + + K N++ + ++ + + EF Sbjct: 169 RITRMAAFMALQHEPPLPIWSLDKANVL-ASSRLWRKTVEETIKNEF 214 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 152 bits (385), Expect = 6e-36, Method: Composition-based stats. Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 38/224 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG--QDVWLPAETLDLIRE 58 IG +V +ML+V+ + + + G + G ++P T+ ++ E Sbjct: 13 IGPEVVDSMLRVLK-------ECNFQSELILCEAGSEQWDKNGRKDASYIPDVTMKILEE 65 Query: 59 YRVAIKGPLTT-PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 KGP TT PV G RS+ V LRQ+ DLY +RP + Y D V FR Sbjct: 66 TDCCFKGPTTTIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLTP----DRKLDCVCFR 121 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 E +E +Y G+E + + I I+ + +G++RL+ +A Sbjct: 122 EATEGLYTGVE-----------------------AKITDDAAIAIRKITRQGSRRLIDSA 158 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 +++A + + V K NI+K T+G F D + A E EL Sbjct: 159 VDWANKFNMKKMVAVTKRNILKQTDGIFWDETQK-AVEGTDIEL 201 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 151 bits (381), Expect = 2e-35, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 77/227 (33%), Gaps = 34/227 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +V++ A + +I G S +G+ L A TL+ + Sbjct: 16 IGPEVVAEATRVLEVVS--ASSSDVEIKLETHDFGGCSIDKHGEP--LTAATLEACKLAD 71 Query: 61 VAIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRYYQG---TPSPVKH--PEL 110 + G + P G +ALR+ L LY +RP + SP+K Sbjct: 72 AILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYSPLKPSVARG 131 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D+++ RE Y G + R E S Sbjct: 132 VDIIVIRELIGGAYFGERKELG-------------------ARAQEDAAWDTMIYSVPEV 172 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 +R+ R+ + A + V + K N++ + ++ + + EF Sbjct: 173 QRITRSRRQVASPDPPLPVHSIDKANVL-ASSRLWRKVATETIQNEF 218 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 150 bits (379), Expect = 3e-35, Method: Composition-based stats. Identities = 47/172 (27%), Positives = 75/172 (43%), Gaps = 26/172 (15%) Query: 50 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP- 108 + I +V +KGP T +S++ L + LY + PV+ Q P V P Sbjct: 130 PDLHQSILNNKVVLKGPFIT--RDVSKSIDRMLALKYGLYAHVVPVKAPQNLPPSVFTPF 187 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 DMV+ REN+E Y+G+E + E +K + + Sbjct: 188 RDVDMVVVRENTEAEYSGLEHQVQPGVVE-----------------------SLKIITRD 224 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 G+ R+ + A EYA + R V +HK NIMK ++G F + Q+A+E + Sbjct: 225 GSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEYPDIQ 276 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 150 bits (379), Expect = 3e-35, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 72/232 (31%), Gaps = 36/232 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + + K++ E G E G + +G + + Sbjct: 14 IGPEAMGEVRKIIAYMNEAMDAG---FVTDEGLVGGCAYDAHG--AAISEADMQKALAAD 68 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----EL 110 + G + P + + LR++L L+ LRP Y S E Sbjct: 69 AVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASASSLKPELVEG 128 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + +Y G + + + GI + Sbjct: 129 LDILIIRELTGGVYFGEPKEI------------------IDLGNGQKRGIDTQVYDTYEI 170 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR-EEFGGEL 221 +R+ A E A + V + K N+MK + + + + + +L Sbjct: 171 ERIAGVAFEMARTRQ-NRVCSMEKRNVMK-SGVLWNQVVTETHKAKYSDVQL 220 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 150 bits (378), Expect = 5e-35, Method: Composition-based stats. Identities = 40/232 (17%), Positives = 72/232 (31%), Gaps = 36/232 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + + KV+ E G + +GQ + ++ Sbjct: 14 IGPEAMAEVRKVI---AFLNSDLNLGFETEEGLVGGCAYDAHGQ--AISDADMEKALAAD 68 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----EL 110 + G + P + + LR+++ LY LRP Y E Sbjct: 69 SVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSSSLKPEVIEG 128 Query: 111 TDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + +Y G + + + GI + Sbjct: 129 LDILILRELTGGVYFGEPKEI------------------IDLGNGQKRGIDTQVYDTYEI 170 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE-EFGGEL 221 +R+ A E A R+ VT + K N+MK + + +E +L Sbjct: 171 ERIADVAFELARTR-RNKVTSMEKRNVMK-SGVLWNQGVTARHKEKHADVQL 220 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 149 bits (376), Expect = 8e-35, Method: Composition-based stats. Identities = 43/230 (18%), Positives = 74/230 (32%), Gaps = 37/230 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + L V++ E+ G + + G Q G E + ++ Sbjct: 17 IGPEIVASSLHVLEVLNERM--GGIGFDFWHLEGGAAHYQKTG--TAFSDENMAACKKAD 72 Query: 61 VAIKGPLTTP----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV--KHPELTDMV 114 + G + P G + + LR E+DLY LRP+R Y P + K D+V Sbjct: 73 AVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDKRASQIDLV 132 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + RE +E I + + S GT R+ Sbjct: 133 LVREQTEGI---------------------LYSRCRGTIEDDRVAWETMMISRNGTSRVS 171 Query: 175 RAAIEYAIANDR-----DSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A A + V V + N + + F+ ++A Sbjct: 172 EFAFRVAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEVAERHPSV 220 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 147 bits (372), Expect = 2e-34, Method: Composition-based stats. Identities = 57/222 (25%), Positives = 89/222 (40%), Gaps = 46/222 (20%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V ++V+ A + + + G Q G + E L+ IR Sbjct: 12 IGPEVIDGAVRVLKAVTGR-------VRFEYYEGGVDVFQECGSP--IREEDLEEIRRSD 62 Query: 61 VAIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 + G TTP G RSL + LR+EL LY LR + ++VI REN Sbjct: 63 AVLFGATTTPFDLPGYRSLILTLRKELGLYANLRIIPDL---------RTGREIVIVREN 113 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 SE +Y GI + + ++ + EG +R+ R A+E Sbjct: 114 SEGLYFGIGAVVNG------------------------RAVDVRLITREGAERIARFAVE 149 Query: 180 YAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A A +T VHK N++ + F+ ++A EE G E+ Sbjct: 150 QAKARG-SFITFVHKANVLT-GDKFFRRIVREVAGEE-GVEV 188 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 147 bits (371), Expect = 3e-34, Method: Composition-based stats. Identities = 57/225 (25%), Positives = 94/225 (41%), Gaps = 36/225 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG + A L V ++K ++++ ++ I G + Q+ LP L+ + Sbjct: 48 IGPYIMKAALLVARKLLKK-EIADQRVEFVPIK-GMTIEERARQNKSLPPAVLEACKACD 105 Query: 61 VAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 + +KGP TP + S N LR++L LY +RP+R + + D F Sbjct: 106 ILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE---------KGIDWTFF 156 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN E Y G K I + I K S+ G +RL R Sbjct: 157 RENIEGEYI---------------------WGNKGICVGDDLAIDFKILSKPGAERLFRN 195 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A EYA ++ + ++T+ K NI+K +G F + + +E G + Sbjct: 196 AFEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHV 240 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 146 bits (368), Expect = 6e-34, Method: Composition-based stats. Identities = 55/222 (24%), Positives = 82/222 (36%), Gaps = 36/222 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V L V+DA + + G+ L LD IR Sbjct: 30 IGPEVIEPALDVLDALGLGTRTDILD------HVNADTYLRTGE--ALTGSDLDRIRSSE 81 Query: 61 VAIKGPLTTPVGGG---IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP--ELTDMVI 115 A+ G + P G +R + LR ELDLY+ RP R + SP++ P D VI Sbjct: 82 AALLGAVGDPRLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARRAIDCVI 141 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+E +Y+GI G + PE + + + G R++ Sbjct: 142 VRENTEGLYSGIG-------------------GGARTGTPEEIAVDVDLSTRHGVSRVLE 182 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A A R SV LV K N ++ ++ + Sbjct: 183 FAFSAA----RRSVCLVDKANAVRNGGQLWQRCWGEAVARHP 220 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 144 bits (364), Expect = 2e-33, Method: Composition-based stats. Identities = 50/214 (23%), Positives = 82/214 (38%), Gaps = 38/214 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V PA + V+ A E S+ E G+ + G LP T + + Sbjct: 17 IGQEVIPAAVAVLQAVDE------VGFSFTEKQAGDDTRDQTG--AALPETTYEAAADAD 68 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + G G + + LR+ + ++ +RP R Y G + TD+V REN+ Sbjct: 69 ATLFGAA----GETAADVILPLREAVGSFVNIRPARAYPGVDALQPE---TDLVFLRENT 121 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E +Y+G E R E + + +++L A Y Sbjct: 122 EGVYSGHE-----------------------DRLSEDLSTLTRVITTSASEQLAEYACSY 158 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 D VHK N+M+ T+G F+D ++A Sbjct: 159 VTERSIDGFHTVHKANVMQETDGRFRDAVSRVAA 192 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 144 bits (364), Expect = 2e-33, Method: Composition-based stats. Identities = 55/213 (25%), Positives = 95/213 (44%), Gaps = 46/213 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR-EY 59 IG +V PA ++++A K + +++ G ++ + G LP +T++++R E Sbjct: 16 IGKEVIPAGRRILEAL---PSYLGLKFEFTDLHAGFETFERTG--AALPDKTVEILRNEC 70 Query: 60 RVAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 A+ G +++P G S VALR++LDLY +RPV+ + + + DMVI R Sbjct: 71 DGALFGAVSSPSSPVKGYSSPIVALRKKLDLYANVRPVK------TVLSAAKPIDMVIVR 124 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN+ED+Y E D+ D + IK SE + R+ A Sbjct: 125 ENTEDLYVKEETTRDTPDGK--------------------VAEAIKRISERASHRIATMA 164 Query: 178 IEYAIANDR------------DSVTLVHKGNIM 198 + A+ + VT+ HK N++ Sbjct: 165 GDIALRRQKIRAAGAPSIHQSPLVTITHKSNVL 197 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 144 bits (363), Expect = 2e-33, Method: Composition-based stats. Identities = 47/222 (21%), Positives = 78/222 (35%), Gaps = 44/222 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++ A+ +V+ A I W + E L +R + Sbjct: 97 VGRELMDAVQEVICAVKA-------PIEWDVHD-----EFKAKDSDDVSPEVLKSLRANK 144 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 V IKGP+ + R +R++ + + + +G SP D+VI R+ Sbjct: 145 VGIKGPVDS------RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQM 195 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E Y+GIE + IK + G R+ Y Sbjct: 196 EGDYSGIEHLVVPGVMQ-----------------------TIKVSTTAGAARIAEFVFNY 232 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 A+ N R +T+ HK NIM+ T+G F + A + L Sbjct: 233 AVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLF 274 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 144 bits (363), Expect = 2e-33, Method: Composition-based stats. Identities = 53/221 (23%), Positives = 85/221 (38%), Gaps = 48/221 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD-VWLPAETLDLIREY 59 I +VT A+ +V+DA Y ++ + G++ L E +D IR+ Sbjct: 8 IDSNVTNAVHQVMDAMQAPVY--------------FETYIIKGKNMNHLTWEVVDSIRKN 53 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFREN 119 +V + G + + GG R+ELDL+ L G PS E D+V+ REN Sbjct: 54 KVCLNGRVNNSLCGGA-------RKELDLFASLVDCFNLNGQPS---RHENVDIVVIREN 103 Query: 120 SEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIE 179 +E YAG E + E ++ + R+ + A E Sbjct: 104 TEGEYAGREHEVVPGVIESFQVT----------------------MTKFWSDRIAKYAFE 141 Query: 180 YAIANDRDSVTLVH-KGNIMKFTEGAFKDWGYQLAREEFGG 219 YA + R VT VH G K + F + ++A+ Sbjct: 142 YAHFSKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMYPNI 182 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 144 bits (362), Expect = 3e-33, Method: Composition-based stats. Identities = 41/233 (17%), Positives = 76/233 (32%), Gaps = 45/233 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ +KV+ + ++ + G S +G V + LD + Sbjct: 15 IGPEIMAEAIKVLTTI--ETHRPNLHFNLTTDLVGGTSIDTHG--VPITQSVLDAAKASD 70 Query: 61 VAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYY-QGT--PSPVKHP--ELT 111 + G + P G S + LRQ LD + LRP + SP++ + T Sbjct: 71 AVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASPIREHVVKGT 130 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 ++ REN Y G + + E + + + Sbjct: 131 RFIVVRENCGGAYFGEKKE------------------------EEDVASDLWVYTRPEIE 166 Query: 172 RLVRAAIEYAIANDRD-------SVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 RL R + A R +V K N++ + ++ + +EF Sbjct: 167 RLARVSAAVARIMGRSEDDNQAATVWSADKANVL-ASGRLWRRITSDIFAKEF 218 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 144 bits (362), Expect = 3e-33, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 87/235 (37%), Gaps = 39/235 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +KV+ ++ + ++ G + G P ET + Sbjct: 14 IGPEVMKEAVKVLKLIEQRNE--DVNFELNDVLFGAAAYFAMGH--AFPDETKAACDKAD 69 Query: 61 VAIKGPLTTPVGGG---------IRSLNVALRQELDLYICLRPVRYYQGTP--SPVKH-- 107 +KG + R + LR+ + + RPV +G SP+K Sbjct: 70 AILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHFSPLKASV 129 Query: 108 -PELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 166 E D++I RE +Y G + +AD ++ ++ + E Sbjct: 130 IGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLE-------------------YD 170 Query: 167 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 E+ +++V+ E ++ + + +HK N++K + + + + ++ E+ Sbjct: 171 EDQIRQIVKVGFEVSMKR-KKVMHNIHKSNVLK-SSVLWNEIVEEESKNYPEVEV 223 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 142 bits (358), Expect = 8e-33, Method: Composition-based stats. Identities = 60/229 (26%), Positives = 117/229 (51%), Gaps = 17/229 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T AM+ VV++A+E AY+G R I W +I G ++ + +G ++P +++ I++ Sbjct: 34 IGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFG--TYVPEDSIKEIQKMY 91 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +A+K T R LN LR+ L LY +R ++Y +G PV ++ I R+++ Sbjct: 92 IAMKS--TLNFMPDKRDLNTILRKRLGLYSNIRILKYIEGMDIPVNTFNRLNLTIIRDST 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + + + S + +I+F+ + G + GI + P S+ T+++ + A+ Y Sbjct: 150 PNSHI---FYHSSESTDDLIRFISDNYG---LNITPDSGIYMMPQSKFRTRKIAKQAVRY 203 Query: 181 AIANDRDSVTLVHKGNIMKFTE------GAFKDWGYQLAR-EEFGGELI 222 + N + +T++ +F A +D GY++ + EF LI Sbjct: 204 SRRNGKKKITILESQQNHEFANWCIEEASAQEDVGYEVLKTREFMKRLI 252 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 142 bits (357), Expect = 1e-32, Method: Composition-based stats. Identities = 45/229 (19%), Positives = 75/229 (32%), Gaps = 35/229 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V + KV+ + E G S +G + E E Sbjct: 17 IGPEVIQEVKKVI---LWLNSNKSLDFEIDEDLAGGCSYDKHGTP--ITDEVFYKALESE 71 Query: 61 VAIKGPLTTPVGGGIRSLNVALR------QELDLYICLRPVRYYQGTPSPVKHPELT--- 111 + G + P + R +EL L+ LRP ++ Sbjct: 72 FVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDASTLKPEIVSG 131 Query: 112 -DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGT 170 D++I RE + IY G E G+K I E GI + Sbjct: 132 LDIMIVRELTGGIYFG------------------EPRGIKPIENGERKGINTHSYTTSEI 173 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 R+ + A + A + VT K N+M+ + +K+ +L +E+ Sbjct: 174 VRVAKVAFDLARKRS-NRVTSCEKSNVMEAGQ-LWKEEVQELHDKEYKD 220 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 141 bits (355), Expect = 2e-32, Method: Composition-based stats. Identities = 43/152 (28%), Positives = 70/152 (46%), Gaps = 12/152 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +++ A+ + +AA + I W E + + A+ LD +R R Sbjct: 42 VGPEISVAVQNIFNAA-------DVPIVWDEHHI--DVDNAKPGQDLISADALDSLRRNR 92 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +KGP+ TP+G G RSLN+ LR+ L LY +RP G +P + D+V REN+ Sbjct: 93 FGLKGPMATPIGKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---DDVDVVTVRENT 149 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKI 152 E Y+G+E E + E + + Sbjct: 150 EGEYSGLEHVVYPGVVESLKVITPERVNARVQ 181 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 140 bits (354), Expect = 2e-32, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 75/232 (32%), Gaps = 36/232 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V + +V+D G + G + G L +T+ L Sbjct: 15 IGPEVMAQVRRVMDWL---NQTGRTAFEVEDALVGGAAYDAQGTP--LHDDTVALALAAD 69 Query: 61 VAIKGPLTTPVGG-------GIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----E 109 + G + P + LR++L+L+ LRP + Sbjct: 70 AVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAEASTLKTELVS 129 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D++I RE + +Y G + G+ + E G+ + Sbjct: 130 GLDVMIVRELTGGVYFG------------------QPRGISALPNGERRGVNTQVYDTHE 171 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R+ + A + A + V K N+M+ + +++ +L + L Sbjct: 172 IVRVAKVAFDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIAL 221 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 140 bits (352), Expect = 4e-32, Method: Composition-based stats. Identities = 50/232 (21%), Positives = 87/232 (37%), Gaps = 42/232 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIR-EY 59 IG ++ + ++V+ AA + + ++ + G + + G + A TL+ IR Y Sbjct: 17 IGPELVRSAVEVLRAAAGR----DVELRFTSEDAGADAFRRTG--SAMSAATLERIRTRY 70 Query: 60 RVAIKGPLTTP-----VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 +KGP+ P G L LR LD Y +RP+ G +P++ D V Sbjct: 71 HGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRG-TAVDYV 129 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 I REN+E +Y + + + G +R+V Sbjct: 130 IVRENTEGLYLSRGRGVGN----------------------DRACADQLLMTRHGVERVV 167 Query: 175 RAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A E A VT V K N+++ + F++ ++A E Sbjct: 168 VHAFELATRRTGAPADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVE 218 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 139 bits (350), Expect = 8e-32, Method: Composition-based stats. Identities = 44/227 (19%), Positives = 74/227 (32%), Gaps = 37/227 (16%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G +V +KV+ A + K + G S + L E L+ + Sbjct: 15 GPEVVLEAIKVLKAIETNSPSAG-KFNLQNHLLGGASIDKHNDP--LTDEALNAAKAADA 71 Query: 62 AIKGPLTTPVGGG-----IRSLNVALRQELDLYICLRPVRY-----YQGTPSPVKHPELT 111 + G + P G + LR+EL Y LRP + +P + T Sbjct: 72 VLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGT 131 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D ++ RE + IY G + D + +P S Sbjct: 132 DFIVVRELTGGIYFGDRTEDDGSG----------------------YACDTEPYSRAEIV 169 Query: 172 RLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R+ R A A+ N V + K N++ T ++ + +EF Sbjct: 170 RIARLAGFLALAKNPPAKVWSLDKANVL-ATSRLWRKTVTDVISKEF 215 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 138 bits (349), Expect = 9e-32, Method: Composition-based stats. Identities = 49/248 (19%), Positives = 87/248 (35%), Gaps = 47/248 (18%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T A ++ E G + +G V P ET + + Sbjct: 25 IGPEITDACRGLI-------ADVFPHWELTETQIGWSQWRAHGNPV--PQETWETLGRSD 75 Query: 61 VAIKGPLTTPV---------------GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPV 105 A+ +T+ G RS + LRQ LDL+ +RPV G + Sbjct: 76 AALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-TLPGAAA-- 132 Query: 106 KHPELTDMVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG 159 D I REN+E +Y+ + ADS + + + + + Sbjct: 133 ------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVARAVDKRGEVA 186 Query: 160 IGIKPCSEEGTKRLVRAAIEYAIANDR--------DSVTLVHKGNIMKFTEGAFKDWGYQ 211 + ++ + RL R A + A+A +VT+ K NI++ + + + Sbjct: 187 VSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSARVIRGAVEE 246 Query: 212 LAREEFGG 219 +A E Sbjct: 247 VAEEYPQV 254 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 138 bits (348), Expect = 1e-31, Method: Composition-based stats. Identities = 50/229 (21%), Positives = 80/229 (34%), Gaps = 39/229 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A + A A + + + E G + + G V ETL E Sbjct: 15 IGPEVVAAARR---VADAAAARFGLTLEYEERRIGAAAIREEGAPV--SKETLRRAGEAD 69 Query: 61 VAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTP--SPVKH--PELTD 112 + G + P G + +ALR+EL + LRPV SP++ E D Sbjct: 70 AVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSPLRPGVAEGVD 129 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 ++I RE + Y G + E + + +R Sbjct: 130 LLIVRELTGGAYFG------------------------EKEEGEERASDLSVYTRGEVER 165 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + R A E A R V V K N++ T ++ ++AR+ L Sbjct: 166 VARVAFEAARGR-RGRVASVDKANVL-ATSRLWRRVVGEVARDYPDVAL 212 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 137 bits (346), Expect = 2e-31, Method: Composition-based stats. Identities = 42/230 (18%), Positives = 80/230 (34%), Gaps = 32/230 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQD--VWLPAETLDLIRE 58 IGV+V + +++D K + + E G + V+G L Sbjct: 14 IGVEVMAQVRRIIDWMGRKR---KIEFEITEGLLGGAAYDVHGTPYPAETLEAALAADAV 70 Query: 59 YRVAIKGPL--TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP----ELTD 112 A+ GP P + +R+++ L+ LRP + D Sbjct: 71 LLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADASTLKAEVVSGLD 130 Query: 113 MVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKR 172 ++I RE + +Y G + G+ + G + +R Sbjct: 131 IMILRELTGGLYFG------------------QPRGIDTLPDGTRKGYNTLVYTTPEIQR 172 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF-GGEL 221 + R A + A + + V K N+++ T +++ +L +EEF EL Sbjct: 173 IGRVAFDLARKRN-KKLCSVDKANVLECT-VLWREEMIKLQKEEFPDVEL 220 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 137 bits (345), Expect = 3e-31, Method: Composition-based stats. Identities = 46/210 (21%), Positives = 73/210 (34%), Gaps = 37/210 (17%) Query: 13 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 72 +DA E + I W + E L +R +V IKGP+ + Sbjct: 1 MDAVQEVICAVKAPIEWDVHD-----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS--- 52 Query: 73 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 132 R +R++ + + + +G SP D+VI R+ E Y+GIE Sbjct: 53 ---RHWQRQIRKQFAQFAYVSLCSHIEGLDSPY---GDFDVVIIRDQMEGDYSGIEHLVV 106 Query: 133 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 192 + IK + G R+ YA+ N R +T+ Sbjct: 107 PGVMQ-----------------------TIKVSTTAGAARIAEFVFNYAVKNKRKRITVA 143 Query: 193 HKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 HK NIM+ T+G F + A + L Sbjct: 144 HKANIMRMTDGNFLEAMRAEADKHVDDVLF 173 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 137 bits (344), Expect = 4e-31, Method: Composition-based stats. Identities = 42/210 (20%), Positives = 78/210 (37%), Gaps = 35/210 (16%) Query: 13 VDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVG 72 +++ V+ + I W + + + + + L+ + ++ IKGP + Sbjct: 2 IESLVKVFSTVQVPIDWDVFH---EHKINSAEGEDVSPKLLESLCRNKIGIKGPFESGPC 58 Query: 73 GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKAD 132 LR++ L+ + R +G + D +I R+ E Y+GIE + Sbjct: 59 ------LRKLRKKFQLFAFVAVCRNLEGQNTRY---GKLDCLIIRDQVEGEYSGIEHRVV 109 Query: 133 SADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 192 + IK + EG R+ R EYA N+R +T+ Sbjct: 110 PGVMQ-----------------------TIKVSTAEGADRMARYVFEYAKKNNRKKITVA 146 Query: 193 HKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 HK NIM+ T+G F + A + + Sbjct: 147 HKANIMRLTDGTFLSPMRREAAKYQDDIMF 176 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 135 bits (340), Expect = 9e-31, Method: Composition-based stats. Identities = 50/252 (19%), Positives = 88/252 (34%), Gaps = 60/252 (23%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYT-GEKSTQVYGQDVWLPAETLDLIREY 59 IG +V A ++A + E+ + +G+ +PA+ + Y Sbjct: 18 IGPEVMAATRHALEAL------PGPALVLTELGWPAHAWHRDHGE--MMPADWRGQLAGY 69 Query: 60 RVAIKGPLTTP-----------VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 108 + G L P G + + LR+ LDL+ C RP G P P+ P Sbjct: 70 DALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGAPMPLSDP 129 Query: 109 ELT--DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 166 D+++ RENSE Y ++ G P ++ + Sbjct: 130 RALHTDLLVIRENSEGEYV-------------------DQGGRLAAGTPRETATQLEVFT 170 Query: 167 EEGTKRLVRAAIEYA----------IANDR---------DSVTLVHKGNIMKFTEGAFKD 207 GT+R++R A E A + R +V +V K N +++ + + Sbjct: 171 RAGTERIIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSE 230 Query: 208 WGYQLAREEFGG 219 ++A E G Sbjct: 231 VFAEVAAEYPGI 242 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 131 bits (329), Expect = 2e-29, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 76/242 (31%), Gaps = 57/242 (23%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ LK++ E+ + +IS+ G S G + E L+ Sbjct: 15 IGPEIIAEALKILAVLEEELPNFKVQISY--GLIGGASLDKTG--SAITDEVLETAVASD 70 Query: 61 VAIKGPLTTPVGGGIRSLN------VALRQELDLYICLRPVRYYQGT---PSPVKH--PE 109 + G + P + + LRQ LD + +RP R+Y + SP+K Sbjct: 71 AVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLNQSPLKPEIAA 130 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D V+ REN Y G + + + Sbjct: 131 GVDFVLVRENCGGAYFGTKTEFEDEA-------------------------------RTE 159 Query: 170 TKRLVRAAIEYAIANDRDS---------VTLVHKGNIMKFTEGAFKDWGYQLAREEF-GG 219 +R R + A R V K N++ + ++ + + EF Sbjct: 160 VERCARVSAALARTFGRGKNTDDKSPAIVWNADKANVL-ASGRFWRTVTHDIFEREFPDI 218 Query: 220 EL 221 EL Sbjct: 219 EL 220 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 129 bits (325), Expect = 6e-29, Method: Composition-based stats. Identities = 42/227 (18%), Positives = 74/227 (32%), Gaps = 37/227 (16%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G +V +KV+ A + K + E G S +V+ + A + + Sbjct: 15 GPEVVAEAVKVLRAIETHSPSVG-KFNLQEHLLGGASIKVHNDPLTAKALAAAKAADAIL 73 Query: 62 AIKGPLTTPVGG-----GIRSLNVALRQELDLYICLRPVRY-----YQGTPSPVKHPELT 111 G + P G + LR+EL Y LRP + +P T Sbjct: 74 L--GAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDSSPLKADVCRGT 131 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTK 171 D ++ RE + IY G + D + + S + Sbjct: 132 DFIVVRELTGGIYFGARTEDDGSG----------------------FAMDTDAYSRAEIE 169 Query: 172 RLVRAAIEYAI-ANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 R+ R A A+ + V + K N++ T ++ ++ EF Sbjct: 170 RIARLAGFLALGTSPPSKVWSLDKANVL-ATSRLWRKVVTEVFANEF 215 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 128 bits (321), Expect = 2e-28, Method: Composition-based stats. Identities = 48/232 (20%), Positives = 83/232 (35%), Gaps = 35/232 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IGVDV A + V++ A++ + GE + EI G + G D + + Sbjct: 11 IGVDVAEAAIAVLETALK--HTGEPAPRYDEIQAGAGYFKETGLD--IEDGGEERAGLAD 66 Query: 61 VAIKGPLTTPV----GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE--LTDMV 114 G + P G S ++ LR LY +RPV+ Y P + P D+V Sbjct: 67 AIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRAAGIDLV 126 Query: 115 IFRENSEDI-YAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRL 173 I RE++E + Y+ K + + + + + + T +L Sbjct: 127 ILRESTEGLFYSAAAHK-------------------RSLVVNDDEVQDVLRITRKTTTKL 167 Query: 174 VRAAIEYAIAND----RDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 R A A +T V K N+ + F+ ++ E + Sbjct: 168 HRFAFNLARKRRERGHPGRLTCVDKANVFT-SLAFFRQIFDEVKSEFADVPV 218 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 127 bits (319), Expect = 3e-28, Method: Composition-based stats. Identities = 48/195 (24%), Positives = 86/195 (44%), Gaps = 33/195 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ +++K+ DAA + + + G + G+ +P + + + Sbjct: 12 IGYEISESLVKIFDAA-------KVPVEFETENAGSDVYEKTGE--LIPESLYESVERNK 62 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 +AIKGP+TTP+G G RS+NV LR++ DLY R R G + + D+ IFREN+ Sbjct: 63 IAIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY---DNIDLAIFRENT 119 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E IY G E + I +K +++G++ L++ + Sbjct: 120 EGIYIGEEKYENEEKT---------------------SAIAVKRITKKGSEELLKVLLNM 158 Query: 181 AIANDRDSVTLVHKG 195 + + L K Sbjct: 159 QRIMEFRKLQLFIKQ 173 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 127 bits (318), Expect = 4e-28, Method: Composition-based stats. Identities = 36/225 (16%), Positives = 78/225 (34%), Gaps = 36/225 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++K+V + + KI+ + Y G S + + + +I+ Sbjct: 12 IGPEIIKQVIKIVKSCI----YTGYKINIIYNYIGGISIDKFNTP--ITNNLISIIKYID 65 Query: 61 VAIKGPLTTPVGGG----IRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 G + + LR++ + + +RP++ P K D++I Sbjct: 66 TIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK---NIDIIIV 116 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RE + IY G + + P K +E+ RL R Sbjct: 117 RELNGGIYYGK---------------PKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARI 161 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + A+ + + + K N+++ T +K + + +L Sbjct: 162 SFNLALNR-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKL 204 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 126 bits (317), Expect = 5e-28, Method: Composition-based stats. Identities = 37/220 (16%), Positives = 79/220 (35%), Gaps = 36/220 (16%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G V A+ K+ AA+ + W + P + LD E + Sbjct: 52 GPVVLAAVRKIFKAAL-------VPVEWDYQTLSVYRDHKTNRMTVNP-QLLDSAIETGL 103 Query: 62 AIKGPLTTPV-GGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + ++P + S ++AL + L+ ++ +R G + ++V RE+ Sbjct: 104 VLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFNSVVG----HEPYGPINLVNIREHV 159 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 Y+ IE + IK S++ + + + A +Y Sbjct: 160 SGEYSEIEHLVSPGVVQ-----------------------SIKTVSKKISVEVAKLAFDY 196 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A + +T++HK ++M+ ++G F +++ E Sbjct: 197 ACKHGHSRITVLHKADVMRLSDGIFLKACREVSACYPDVE 236 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 125 bits (315), Expect = 8e-28, Method: Composition-based stats. Identities = 39/228 (17%), Positives = 71/228 (31%), Gaps = 55/228 (24%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V +L + D K+ E G + + TL E Sbjct: 23 IGPEVMAEVLPLFDVIQSHF---GIKVETFERLIGGSCLDQHD--CPIQESTLQEASECH 77 Query: 61 VAIKGPLTTPVGG------GIRSLNVALRQELDLYICLRPVRYYQGTP---SPVKHP--E 109 + G + P + + +R+ L+LY +RP + S +K Sbjct: 78 AVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLELSSLKEHVVR 137 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 +++ REN+ IY G + + D Sbjct: 138 GVNIITLRENAGGIYFGRKQEPDPLAH--------------------------------- 164 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 +AA+ A ++ + V K N+M T ++ + R+EF Sbjct: 165 -----KAALSLASSHGPLPIISVDKANVM-ATSRLWRQVVTETIRDEF 206 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 123 bits (310), Expect = 3e-27, Method: Composition-based stats. Identities = 37/217 (17%), Positives = 76/217 (35%), Gaps = 21/217 (9%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ P + +V + + +++ + G + + +D ++ Y Sbjct: 12 IGKEIIPQVCDLVTSI-------DPSVNFTFYNISSERYINKG--ITIKDSEIDELKSYN 62 Query: 61 VAIKGPLTT---PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 G + G + + + LR+ELDLY+ +RP + M I R Sbjct: 63 SIFFGAIGDFRVKPGIMEQGVILRLRKELDLYMNIRPAISFSRITG-----NNIHMTILR 117 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN ED Y+ I + + + + S + KR A Sbjct: 118 ENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNLKRFFNMA 177 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 + A D ++VT+ K N + +++ + + Sbjct: 178 YKIA---DTETVTITDKANAVDMYS-LWREIAIEESE 210 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 120 bits (302), Expect = 3e-26, Method: Composition-based stats. Identities = 41/223 (18%), Positives = 74/223 (33%), Gaps = 39/223 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A LK++ + + + G + + G + P T +L Sbjct: 19 IGPEVVEASLKILQHVAKI---QGFTLQVDYGWLGATAFEQLG--SYFPQATTELCDGAD 73 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVK-HPELT---DMVIF 116 + G ++ + + LR+ D + LRP+R PE D++I Sbjct: 74 GIVFGAVS-------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLRPEKIQGLDILIV 126 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 RE IY G ++ + G +E +R+ R Sbjct: 127 RELVSGIYFGPSGRSSDE--------------------RGNYGYHTMRYYDEEIRRIARK 166 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A+E A R +T+ HK N + + + A + Sbjct: 167 ALEQAQYR-RGLLTVAHKENALPHLH--WTRLVQEEATKFPNV 206 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 118 bits (297), Expect = 1e-25, Method: Composition-based stats. Identities = 51/225 (22%), Positives = 84/225 (37%), Gaps = 31/225 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ ++ V+ A++ GE ++ + G ++ G+ +P ET + I Sbjct: 17 IGPEIVAPTVQAVELALQA--SGEATPEFVPLLLGREAINATGR--IVPEETWETITGLD 72 Query: 61 VAIKGPLTT----PVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIF 116 I GP P G + + LR++ DL+ +RPVR G P D+VI Sbjct: 73 GWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP-----DLDVVIV 127 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 REN+E +YA S D + + + Sbjct: 128 RENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAAI------------ 175 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A +T+ HK N++ T G + A EEFG E+ Sbjct: 176 -----AAARDGVLTVAHKSNVLTETSGRYVAEAKACA-EEFGVEV 214 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 118 bits (296), Expect = 1e-25, Method: Composition-based stats. Identities = 41/218 (18%), Positives = 81/218 (37%), Gaps = 31/218 (14%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ P + + + I+++ + G + + + L+ ++ YR Sbjct: 12 IGREIMPGVAAAISSIS--------DINFVTFDISSERYIKTG--IIIKDDELEELKNYR 61 Query: 61 VAIKGPLTTP---VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFR 117 + G + P G + + + LR+EL+LY+ +RPVR + + + I R Sbjct: 62 AILFGAIGDPRVRPGIMEQGVILRLRRELELYMNIRPVRSFD---------DKIKITILR 112 Query: 118 ENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAA 177 EN++D Y I + V E G + + S K+ A Sbjct: 113 ENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSC----DEVYYTMGMLSYRYLKKFFNKA 168 Query: 178 IEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 + +VT+ K N +K ++ + A E Sbjct: 169 FSICDS----TVTVTDKANAVKMYN-LWRSTAMEAAIE 201 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 115 bits (287), Expect = 2e-24, Method: Composition-based stats. Identities = 39/232 (16%), Positives = 76/232 (32%), Gaps = 38/232 (16%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G ++T + + A E R + E G + LP E+L E Sbjct: 24 VGPEITREAVLTLKRAGEV---YGRSFQFTEAIAGTAALDR--GQCPLPRESLKTCLEAD 78 Query: 61 VAIKGPLTTPVGGGIR------SLNVALRQELDLYICLRPVRYYQGTP--SPVK---HPE 109 + G L G++ S+ LR L L +RP + + P+K + Sbjct: 79 SILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELCPLKEEIRKK 138 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D++I R+ + ++ ++ + + E Sbjct: 139 GMDILIIRDIAGGMFTTEGKSSNLCNVR--------------------AAWDTESYDETL 178 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 + R A + A + R VT + K I+ + ++ + R+ EL Sbjct: 179 IRDSARLAFQLAASRKRK-VTSLDKA-ILLSSSVLWRQILEETHRDYPEIEL 228 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 110 bits (274), Expect = 5e-23, Method: Composition-based stats. Identities = 44/223 (19%), Positives = 74/223 (33%), Gaps = 33/223 (14%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G + + + +D K+S + G LP+ TL R+ Sbjct: 21 GPYLASYVERTLDLIQRVRRNVSFKVSRHDF---GGVALAAGAGTALPSTTLGACRQSDA 77 Query: 62 AIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGT---PSPVKHP--ELTDMVI 115 + P G + LRQEL+ + +RPVR+ S K E D+ Sbjct: 78 VLVCGCGDPRYGIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSSYKPEVVEQLDITF 137 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 FR+ + +Y G +A + P S + +R+ R Sbjct: 138 FRDLTSGVYYGRRKEAG----------------------DDGEAYDTTPYSRQTIERIAR 175 Query: 176 AAIEYAIA-NDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 A YA+ + V + K N+M T ++ + EF Sbjct: 176 LAGTYAMQFSPPKPVHSIDKHNVM-ATSRLWRSVVAHVFENEF 217 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 106 bits (265), Expect = 5e-22, Method: Composition-based stats. Identities = 42/220 (19%), Positives = 73/220 (33%), Gaps = 39/220 (17%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 I +++ A+ V DA +I ++ + ++S + G ++ E +R Y Sbjct: 19 IARELSQAVHTVADALP-------FEIEFIPVDLSDESREAKGDAIY--DEAEAAMRRYG 69 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 ++K P T S N LR+ + + RPV G + E + I R + Sbjct: 70 TSLKYPTAT----TKESPNRVLRERCNFAVIHRPVATIPGIQTHYN--ERIHLDIVRIAT 123 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 Y R + I+ + R A Sbjct: 124 GGTYEDAG-----------------------RRINRDTAVSIRAIERRPSVLASRFAFRL 160 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 A D +V K I K T+G F++ +AR+ E Sbjct: 161 AQLRD-SNVIATSKYTIQKATDGLFQEAARGVARDYPATE 199 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 106 bits (264), Expect = 6e-22, Method: Composition-based stats. Identities = 25/128 (19%), Positives = 45/128 (35%), Gaps = 26/128 (20%) Query: 82 LRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIK 141 L LDLY + ++ + + D+++ EN+E Y+ +E ++ E Sbjct: 2 LHTTLDLYASVIHLKNLPNVET---WHKDVDILVVWENTEGEYSNLEHESVKGVTE---- 54 Query: 142 FLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFT 201 +K ++ + R+ A + A V VHK NI K Sbjct: 55 -------------------SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLG 95 Query: 202 EGAFKDWG 209 +G F Sbjct: 96 DGPFLQCC 103 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 105 bits (263), Expect = 8e-22, Method: Composition-based stats. Identities = 40/229 (17%), Positives = 76/229 (33%), Gaps = 22/229 (9%) Query: 7 PAMLKVVDAAV-EKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +V+ A + EK I M + V + + I+ + V +K Sbjct: 194 DEMARVIWAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTI--DAALAIKRHGVGVKC 251 Query: 66 PLTTPVG---------GGIRSLNVALRQELDLYICLRPV--RYYQGTPSPVKHPELTDMV 114 TP +S N +R LD I P+ + P ++ Sbjct: 252 ATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPILMKNVPRLVPSWTKP----II 307 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP---CSEEGTK 171 I R D Y +++ D + ++ + E G G+ ++ K Sbjct: 308 IGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKGGGVALGMYNTDASIK 367 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 + +YA+ + L K ++K +G FKD + +E+ + Sbjct: 368 GFAHSCFQYALDQKMP-LYLSTKNTVLKKYDGRFKDIFQTIYEKEYKQK 415 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 105 bits (263), Expect = 8e-22, Method: Composition-based stats. Identities = 42/226 (18%), Positives = 78/226 (34%), Gaps = 34/226 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKIS-WMEIYTGEKSTQVYGQDVWLPAETLDLIREY 59 +G +V L ++ E ++ G ++ ++ G+ L E D + Sbjct: 38 VGPEVIDVALSLLRLLGE---ATGQRFEVRTGGPIGRQAERLTGRG--LTPEVRDFCAQV 92 Query: 60 RVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPS----PVKHPELTDMVI 115 A G + GGG LR+ DLY L P+R++ + D++I Sbjct: 93 -FAQGGAVLCGPGGG--RFVYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAARSADVLI 149 Query: 116 FRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVR 175 REN+ +Y G EW ++ A + + + +R++R Sbjct: 150 VRENASGLYCG-EWGSEGEGAAR-------------------SAYQVCRYRADEVERILR 189 Query: 176 AAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 A+ A R + +V K + + D +A E Sbjct: 190 TALRLAGQR-RGDLVVVTKPGGVPAISALWHDALTAVAGEHGAVRC 234 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 105 bits (263), Expect = 8e-22, Method: Composition-based stats. Identities = 32/230 (13%), Positives = 82/230 (35%), Gaps = 23/230 (10%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +++ + EK ++ G ++ V + + I+++ V +K Sbjct: 16 DEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV--TKDAAEAIKKHNVGVKC 73 Query: 66 PLTTPVGGGI---------RSLNVALRQELD--LYICLRPVRYYQGTPSPVKHPELTDMV 114 TP + +S N +R L ++ + S P ++ Sbjct: 74 ATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKP----II 129 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLRE---EMGVKKIRFPEHCGIGIKPCSEEGT- 170 I R D Y ++ ++ + ++ F E G+ + +++ + Sbjct: 130 IGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSI 189 Query: 171 KRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 + ++ + A++ + L K I+K +G FKD ++ +++ + Sbjct: 190 EDFAHSSFQMALSKGWP-LYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQ 238 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 103 bits (257), Expect = 4e-21, Method: Composition-based stats. Identities = 41/222 (18%), Positives = 66/222 (29%), Gaps = 48/222 (21%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V A +A E ++W V + T D+ Sbjct: 26 IGPEVIEAGNY--QSAEETNRVAWILLNWPSRTLSGA--------VRITRNTADISPISS 75 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 S + LR + P R + G SP+ D VI RENS Sbjct: 76 STFLW----------FSSYLPLRSS---TSNM-PTRVFHGIQSPLH----LDWVIVRENS 117 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 E YAG G P I + G +R+++ A E Sbjct: 118 EGEYAGHG-------------------GRSYAGKPWEVATDISIFTRHGVERIMKFAFEA 158 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDW-GYQLAREEFGGEL 221 A + + +T+ K N + + + ++A + Sbjct: 159 ARSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTC 200 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 100 bits (249), Expect = 4e-20, Method: Composition-based stats. Identities = 30/168 (17%), Positives = 62/168 (36%), Gaps = 28/168 (16%) Query: 50 AETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 E + + A+ + + ++ + +LDLY+ + +R + G Sbjct: 107 EEYFNSVLRNHAAV--HVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKCRFP--- 161 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D+ + +N+ Y+ +E+ E ++ + E Sbjct: 162 DVDIQVIAQNNIGNYSELEYAPVKGVVE-----------------------ALRVVTHEN 198 Query: 170 TKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 + +R A E AI R VTL+HK N T+GA + ++ E++ Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAEDY 246 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 99.7 bits (247), Expect = 7e-20, Method: Composition-based stats. Identities = 36/238 (15%), Positives = 72/238 (30%), Gaps = 46/238 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETL-DLIREY 59 +G DV P K + A E G ++ G + G+ + + L + I + Sbjct: 14 VGKDVIPLGAKAMQKAQEIL--GGFELDCRYYEAGVEYAVKTGK---MCEDNLGEDIAKA 68 Query: 60 RVAIKGPLTTPVGGGIRS----------LNVALRQELDLYICLRPVRYYQGTPSPVKHPE 109 + G +S + LR + I LRP+R +G P+++ E Sbjct: 69 DAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKGIDCPLRNRE 128 Query: 110 LTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEG 169 D+++ R+ +E Y E + Sbjct: 129 EIDVLLVRQLAEGFYIRPGH-----------------------MIGEDAAYDTIVVTRNV 165 Query: 170 TKRLVRAAIEYAIAN------DRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 T++ A + VTL +K + + ++ +++ L Sbjct: 166 TEKFADTCFRLARGRHGRRQDGKKMVTLGNKHGNVTCFD-FYRKIFTEVSAGYPDIGL 222 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 98.9 bits (245), Expect = 1e-19, Method: Composition-based stats. Identities = 41/227 (18%), Positives = 77/227 (33%), Gaps = 22/227 (9%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +++ EK I G + V + ++ ++Y VA+K Sbjct: 56 DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTI--DSALATQKYSVAVKC 113 Query: 66 PLTTPVGGGI---------RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMV 114 TP + +S N +R L + P + P + Sbjct: 114 ATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWTKP----IT 169 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKP---CSEEGTK 171 I R D Y ++ AD A K++ ++ GVK+ G+ ++E Sbjct: 170 IGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESIS 229 Query: 172 RLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFG 218 + +YAI + + K I+K +G FKD ++ + + Sbjct: 230 GFAHSCFQYAIQKKWP-LYMSTKNTILKAYDGRFKDIFQEIFDKHYK 275 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 97.8 bits (242), Expect = 2e-19, Method: Composition-based stats. Identities = 31/168 (18%), Positives = 63/168 (37%), Gaps = 28/168 (16%) Query: 49 PAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHP 108 + + + R A+ + V + ++ L +LDLY+ VR + G Sbjct: 97 TDDFYNSVLRNRSAV--HVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRFP-- 152 Query: 109 ELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEE 168 ++ I +N+ +Y+ +E+ E I ++E Sbjct: 153 -DVNIRIIAQNNMGVYSDLEYSPVKGVVE-----------------------AISVSTQE 188 Query: 169 GTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREE 216 G ++ +R A A+ +R VTL+HK T+GA ++ ++ Sbjct: 189 GNEKYLRKAFATAVKANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDY 236 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 95.9 bits (237), Expect = 9e-19, Method: Composition-based stats. Identities = 36/219 (16%), Positives = 62/219 (28%), Gaps = 29/219 (13%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ ++V+D + ++ + V ++ +R Sbjct: 16 GQELLDQAVRVLD-----PEVTGLPLELERFDLSLENRRATQNGVV--SDAAAAMRTCGF 68 Query: 62 AIKGPLTTPVG-GGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 IK TP G + S N LR+E+D + +R R G I R Sbjct: 69 GIKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGVTPIAGVHYPIS--IVRMAI 126 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 ED Y +W+ A A + + + + + A Sbjct: 127 EDAYGAKQWREGDAGAA------------------DEVAYRTEHVTRSTCRAVSEYAFRT 168 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A A V K + EG K+ A Sbjct: 169 ARAMQ-ARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDV 206 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 95.1 bits (235), Expect = 1e-18, Method: Composition-based stats. Identities = 46/180 (25%), Positives = 96/180 (53%), Gaps = 19/180 (10%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++T AM+ V++A+E AY G + I W +IY G ++ + YG+ +LP E+++ IR+ Sbjct: 27 GTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGK--YLPRESIEDIRKTVF 84 Query: 62 AIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSE 121 +KGPL++ + G +N+ +++ L+LY ++ + G E ++ IF + + Sbjct: 85 VMKGPLSSNING--HDININIKRILNLYTDVKCITGLPGLS------EGKEIFIFSPSID 136 Query: 122 DIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYA 181 ++Y + DS D++ + ++L++ + I +K S R+++ A + A Sbjct: 137 EVY---HFSYDSEDSDMLRQYLQQSFNIS---IGGDSDIFLKGTSRY---RIIKIASKIA 187 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 93.2 bits (230), Expect = 6e-18, Method: Composition-based stats. Identities = 31/204 (15%), Positives = 64/204 (31%), Gaps = 21/204 (10%) Query: 31 EIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIR---------SLNVA 81 G + V + E + I++Y V +K TP + S N Sbjct: 97 HRPQGIEYRDQTDDKVTV--EAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGT 154 Query: 82 LRQELDLYICLRPV--RYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKV 139 +R L + P+ P ++I R D Y + ++ Sbjct: 155 IRNILGGTVFREPIVIPAIPRLVPGWTKP----IIIGRHAFGDQYRATDRVIPGPGKLEL 210 Query: 140 IKFLREEMGVKKIRFPEHCGIGIKP---CSEEGTKRLVRAAIEYAIANDRDSVTLVHKGN 196 + + G G+ +++ + ++ + A+ + + K Sbjct: 211 VYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLP-LYMSTKNT 269 Query: 197 IMKFTEGAFKDWGYQLAREEFGGE 220 I+K +G FKD ++ E+ E Sbjct: 270 ILKRYDGRFKDIFQEIYEAEYKKE 293 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 90.5 bits (223), Expect = 4e-17, Method: Composition-based stats. Identities = 35/219 (15%), Positives = 71/219 (32%), Gaps = 30/219 (13%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++ L+V+ +V + + + +++ ++ + V E R+ + Sbjct: 17 GEELLIQALRVLQPSVIR-----QPLQFLDYDLSLENRRATDNKVV--WEAAQAARDSGL 69 Query: 62 AIKGPLTTP-VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 ++K TP + G + S N LR+ L+ + LR R + I R Sbjct: 70 SLKAATITPEIAGDVGSPNAILREALNAKVILRTGRRIPKIRPIAGVYSP--IAIVRMAV 127 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 +D Y EW+ + + + S + + +Y Sbjct: 128 DDAYGSKEWRETTEN-------------------GDEIAYRTSKISRSTCRAVAEFTFQY 168 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGG 219 A + V K + EG FK+ A+ Sbjct: 169 A-KRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEV 206 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 89.7 bits (221), Expect = 7e-17, Method: Composition-based stats. Identities = 28/163 (17%), Positives = 56/163 (34%), Gaps = 17/163 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ + ++ + + ++ ST + IR Sbjct: 61 IGPELLNHVRELFR-------FSCVPVDFEVVHVNSSSTSEDDISN-----AIMAIRRNG 108 Query: 61 VAIKGPLTTP--VGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRE 118 VA+KG + T + +S N LR LDLY + + G + + D++I E Sbjct: 109 VALKGNIETNHTMPPNHKSRNNLLRTSLDLYANVMHCQSLPGVQT---RHKNIDIIIILE 165 Query: 119 NSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIG 161 SE E + + ++ L + + ++ I Sbjct: 166 KSEFSALLAENEKIKVELLQLRIQLADVINKRRADIILDLNIE 208 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 88.2 bits (217), Expect = 2e-16, Method: Composition-based stats. Identities = 35/221 (15%), Positives = 64/221 (28%), Gaps = 43/221 (19%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V +++ E+ G ++ G LPA TL Sbjct: 12 VGEEVLDGPTRLLRLLAERGEVE----VTGPWPVGARAAAETGD--VLPAGTLAACDAAD 65 Query: 61 VAIKGPLT----TPVGGGIRS--LNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMV 114 + G + P G R LR+ DL I +R + + G ++ Sbjct: 66 AILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGR----------ELT 115 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLV 174 + R Y G + + D + + + E +V Sbjct: 116 VVRNLIGGSYGGADDRVLREDGSE--------------------AADVLRLTRERVAEVV 155 Query: 175 RAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 A + + V K N + T ++ +ARE Sbjct: 156 HTACDVLGRRGGGRLVSVDKAN-LYATGRLWRQVAGDVARE 195 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 83.5 bits (205), Expect = 5e-15, Method: Composition-based stats. Identities = 21/105 (20%), Positives = 37/105 (35%), Gaps = 11/105 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V V+ A + + E+ G + + G V LP ETL + ++ Sbjct: 53 IGPEVISVAKNVLKLAGSL---EGIEFGFQEMPVGGCALDLTG--VPLPEETLLVAKQSD 107 Query: 61 VAIKGPLTTPVGGG------IRSLNVALRQELDLYICLRPVRYYQ 99 + G + + + LR L ++ LRP Sbjct: 108 AVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 83.1 bits (204), Expect = 6e-15, Method: Composition-based stats. Identities = 39/229 (17%), Positives = 76/229 (33%), Gaps = 22/229 (9%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +V+ +K + G + V + E+ + +Y VA+K Sbjct: 93 DEMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDKVTV--ESAEATLKYNVAVKC 150 Query: 66 PLTTPVGGGI---------RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMV 114 TP + RS N +R L+ + P K P + Sbjct: 151 ATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCLNIPRIVPGWKKP----IC 206 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCG--IGIKPCSEEGTKR 172 I R D Y + K+I + ++ + G + + + + + R Sbjct: 207 IGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKGPGVALAMYNVDQSIR 266 Query: 173 -LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 +++ A A + L K I+K +G FKD ++ E++ + Sbjct: 267 AFAESSMSLAFAKKWP-LYLSTKNTILKKYDGRFKDIFQEVYEEKWKQK 314 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 82.0 bits (201), Expect = 1e-14, Method: Composition-based stats. Identities = 40/224 (17%), Positives = 74/224 (33%), Gaps = 23/224 (10%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +V+ + +K ++ G V + E+ + ++Y VAIK Sbjct: 18 DEMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKVTV--ESAEATQKYNVAIKC 75 Query: 66 PLTTPVGGGI---------RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMV 114 TP + RS N +R L+ + P + P + Sbjct: 76 ATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCKNIPRLVPGWTKP----IC 131 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLR---EEMGVKKIRFPEHCGIGIKPCSEEGTK 171 I R D Y + A K++ E+ + F G+ + + + + Sbjct: 132 IGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNFTGAGGVALSMYNTDESV 191 Query: 172 R-LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAR 214 R A++ A + L K I+K +G FKD ++ Sbjct: 192 RSFAEASMNMAFQKKWP-LYLSTKNTILKKYDGRFKDIFQEVYE 234 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 80.1 bits (196), Expect = 6e-14, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 76/212 (35%), Gaps = 32/212 (15%) Query: 3 VD--VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 + V PA L+++++A A I G+ G P Sbjct: 18 PEASVLPAALELLESAGLTANW--------RIVAGQAP---DGDGGRKPE---------- 56 Query: 61 VAIKGPLTTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENS 120 + P P G L A R+ + V+ ++++FR Sbjct: 57 AGLLPPFAEP-GASAYGLARAARRAWG-----GTFSVIERRGPLVRSDGTVNVLLFRYEL 110 Query: 121 EDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEY 180 + G+E++++S + ++K E + PE +GI+ + + VR A+ Sbjct: 111 DMSDTGMEFESNSGEQLALVKTAAE---LGPREIPEQAALGIQAIAPDRVSEFVRTAVGM 167 Query: 181 AIANDRDSVTLVHKGNIMKFTEGAFKDWGYQL 212 D D + + HKGN +K T+G F + Sbjct: 168 CRRLDVDDLVVAHKGNSIKHTDGLFALTAAET 199 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 77.4 bits (189), Expect = 3e-13, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 37/103 (35%), Gaps = 10/103 (9%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ LK + VE+ + ++ + S + + + LD Sbjct: 15 IGPEIIAEALKPLTVLVEERPDFKVQVRY--GLLAGASLDKTNEP--ITDKVLDAALATD 70 Query: 61 VAIKGPLTTPVGGGIRSLN------VALRQELDLYICLRPVRY 97 + G + P + + LRQ LD + +RP R+ Sbjct: 71 AVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRF 113 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 72.7 bits (177), Expect = 8e-12, Method: Composition-based stats. Identities = 25/177 (14%), Positives = 50/177 (28%), Gaps = 40/177 (22%) Query: 16 AVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGI 75 + I G+ E + R A+ + Sbjct: 82 VSSLLSSSRVPVEVQVIEAGQD------------DEYFHSVLRNRTAV--HVDNQADAEA 127 Query: 76 RSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSAD 135 + + + +LDLY+ R + G D+ + +N+ I+ +E+ Sbjct: 128 KQKALKICNDLDLYVFKTRTRSFPGFKCRFP---GVDIQLIGQNNMGIFNELEYSPVEGV 184 Query: 136 AEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLV 192 E + S++G + +R A + A R VTL+ Sbjct: 185 VE-----------------------ALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 71.2 bits (173), Expect = 2e-11, Method: Composition-based stats. Identities = 34/228 (14%), Positives = 73/228 (32%), Gaps = 21/228 (9%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +++ ++ + G V + ++ + + VA+K Sbjct: 48 DEMTRIMWQMIKDELICPFVDLKTEYYDLGLAHRDETDDQVTV--DSAEATKRLGVAVKC 105 Query: 66 PLTTPVGGGI---------RSLNVALRQELDLYICLRPV--RYYQGTPSPVKHPELTDMV 114 TP + +S N +R LD + P+ R P + Sbjct: 106 ATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPIVVRGIDPCVKNWVRP----IT 161 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKK--IRFPEHCGIGIKPCSEEGTKR 172 + R D+Y E + +++ + ++ F E + + + Sbjct: 162 LARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGVVEGMHNLDASIES 221 Query: 173 LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 RA ++A+A +D V K I K + FKD ++ ++ Sbjct: 222 FARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAAR 268 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 70.4 bits (171), Expect = 4e-11, Method: Composition-based stats. Identities = 34/215 (15%), Positives = 69/215 (32%), Gaps = 22/215 (10%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +++ +K + G + V + E+ + +Y VA+K Sbjct: 73 DEMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDKVTV--ESAEATLKYNVAVKC 130 Query: 66 PLTTPVGGGI---------RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMV 114 TP + RS N +R L+ + P K P + Sbjct: 131 ATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPILCXNVPRIVPGWKKP----IC 186 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHC--GIGIKPCSEEGTKR 172 I R D Y + + K++ ++ + GI + + + + R Sbjct: 187 IGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKGPGIALAMYNVDESIR 246 Query: 173 -LVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFK 206 +++ A A + L K I+K +G ++ Sbjct: 247 AFAESSMSLAFAKKWP-LYLSTKNTILKKYDGRYE 280 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 68.5 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 35/108 (32%), Gaps = 15/108 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++ KV+D K + I G S G V L E + + Sbjct: 13 IGPEIVAEAKKVLDKIGTK---YGHSFLYEAILMGGCSIDATG--VPLTDEAIAAAKASD 67 Query: 61 VAIKGPLTTPVGGGIR----------SLNVALRQELDLYICLRPVRYY 98 + G + + + LR+ L+L+ LRP Y Sbjct: 68 AVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 62.7 bits (151), Expect = 8e-09, Method: Composition-based stats. Identities = 26/141 (18%), Positives = 53/141 (37%), Gaps = 9/141 (6%) Query: 76 RSLNVALRQELDLYICLRP--VRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADS 133 RS N +R L+ + P + S K P + I R D Y + + Sbjct: 32 RSPNGTIRNILNGTVFREPILCKNVPRILSGWKKP----ICIGRHAFGDQYRATDTIING 87 Query: 134 ADAEKVIKFLREEMGVKKIRFP-EHCGIGIKPCSEEGTKR-LVRAAIEYAIANDRDSVTL 191 K++ V+ + + G+ + + + + R +++ A++ + L Sbjct: 88 PGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWP-LYL 146 Query: 192 VHKGNIMKFTEGAFKDWGYQL 212 K I+K +G FKD ++ Sbjct: 147 STKNTILKKYDGRFKDIFQEV 167 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 62.7 bits (151), Expect = 9e-09, Method: Composition-based stats. Identities = 32/233 (13%), Positives = 73/233 (31%), Gaps = 28/233 (12%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKIS-WMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 G ++T +++ + + + IS W K+ + + ++ + Sbjct: 89 GEEMTHYATQLL---LNQWIEPYFDISSWETFDLSCKARDDSDDATLI--DAVEAGKRIG 143 Query: 61 VAIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELT 111 K P TP ++ S N A+R+ + R + +G K+ Sbjct: 144 AIFKEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQ--- 200 Query: 112 DMVIFRENSEDIYAGIEWKADSADAEKVIKFLRE---EMGVKKIRFPEHCGIGIKPCSE- 167 ++ R Y G W ++ V K + + + + Sbjct: 201 -VLFERHAVGGEY-GAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPY 258 Query: 168 EGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAF---KDWGYQLAREEF 217 + + L + + + +V K + K+ EG + K ++EF Sbjct: 259 DNVRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFWATMKRVFDDTYKDEF 310 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 62.0 bits (149), Expect = 1e-08, Method: Composition-based stats. Identities = 16/150 (10%), Positives = 36/150 (24%), Gaps = 23/150 (15%) Query: 68 TTPVGGGIRSLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGI 127 P + LR+E+ Y +RP + D Sbjct: 36 GAPATSRPERGLLKLRKEMGTYGSMRPCFFA----------------------SDSLVAP 73 Query: 128 EWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRD 187 + + + + + +P S +R A Sbjct: 74 QGRGVPRHRLCHCARAHRRYLLWRAQTGSGSAWNTEPYSHAEVERFTHLAGFLTRGRGDK 133 Query: 188 SVTLVHKGNIMKFTEGAFKDWGYQLAREEF 217 + + N++ T ++ + +EF Sbjct: 134 KLWSLDNANVL-ATSRFWRKVMTETFEKEF 162 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 62.0 bits (149), Expect = 2e-08, Method: Composition-based stats. Identities = 18/87 (20%), Positives = 39/87 (44%), Gaps = 5/87 (5%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +V ++ V+ + E ++ + E+ G + G+ ++PA+ L ++ + Sbjct: 19 IGPEVVNVIIDVLKSLQEILST--YRLEFTELDWGTARYKRTGK--YMPADGLSTLKTFH 74 Query: 61 VAIKGPLTTPVGG-GIRSLNVALRQEL 86 I G + P IR L+ +R+ Sbjct: 75 AGIFGAVGAPGMKFCIRRLDFGVRRTF 101 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 60.0 bits (144), Expect = 6e-08, Method: Composition-based stats. Identities = 24/150 (16%), Positives = 46/150 (30%), Gaps = 18/150 (12%) Query: 7 PAMLKVV-DAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKG 65 M +++ +K I G + V L + + I++Y V +K Sbjct: 22 DEMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTL--DAAEAIKKYSVGVKC 79 Query: 66 PLTTPVGGGIR---------SLNVALRQELDLYICLRPV--RYYQGTPSPVKHPELTDMV 114 TP + S N +R L + P+ K P ++ Sbjct: 80 ATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPIVIPAIPRLVPSWKQP----II 135 Query: 115 IFRENSEDIYAGIEWKADSADAEKVIKFLR 144 I R D Y + D+ +++ + Sbjct: 136 IGRHAFGDQYRAKDRVIDTEGTLEMVFTPK 165 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 57.7 bits (138), Expect = 3e-07, Method: Composition-based stats. Identities = 29/236 (12%), Positives = 68/236 (28%), Gaps = 25/236 (10%) Query: 2 GVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRV 61 G ++T ++ ++ A + W E ++ + + + ++ + + Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTA--WREFDL--RAKNRDDTEDQVLRDVIEAGKAVKA 73 Query: 62 AIKGPLTTPVGGGIR---------SLNVALRQELDLYICLRPVRYYQGTPSPVKHPELTD 112 K P TP ++ S N A+R+ + R + G K P + Sbjct: 74 IFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE 133 Query: 113 MVIFRENSEDIYA------GIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCS 166 R YA G + + + + + Sbjct: 134 ----RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNP 189 Query: 167 EEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGELI 222 + L R + +V K + K+ E + ++ EE+ + + Sbjct: 190 YDNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFW-QIMKKVFDEEYKSKFV 243 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 57.7 bits (138), Expect = 3e-07, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 35/92 (38%), Gaps = 14/92 (15%) Query: 3 VDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVA 62 ++ ++ V+ A I + I +V + + I R+ Sbjct: 77 PELMNSVQTVLKAI-------GAPIDFETILFS----EVQHSSSAKVEDVIKSINRNRIC 125 Query: 63 IKGPLTTPV---GGGIRSLNVALRQELDLYIC 91 + G L +P G +++L++ LR+ LDL Sbjct: 126 LMGALMSPDVSYSGELQNLHMKLRKGLDLIAN 157 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 57.7 bits (138), Expect = 3e-07, Method: Composition-based stats. Identities = 14/96 (14%), Positives = 31/96 (32%), Gaps = 13/96 (13%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG+++T +KV+ A +R S G + + + Sbjct: 373 IGLEITAEAVKVLSA----FSLKKRTFDLRSELIDGCSIDTDGTP--ITKTVIQAALDSD 426 Query: 61 VAIKGPLTTPVGGGIR-------SLNVALRQELDLY 89 + + P G+R + LR+ ++ + Sbjct: 427 AVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 56.9 bits (136), Expect = 5e-07, Method: Composition-based stats. Identities = 34/225 (15%), Positives = 69/225 (30%), Gaps = 39/225 (17%) Query: 5 VTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIK 64 V L ++ ++V E+ G + + LP +TL ++ Y + Sbjct: 16 VIDRALGIIKSSV----NDSTAFEVTELPFGVNGVLSFNEP--LPNQTLRELKNYDGILV 69 Query: 65 GPLTTPVGG----GIRSLNVALRQELDL----YICLRPVRYYQGTPSPVKHPELTDMVIF 116 G L VG ++ VALR+ L++ +P + TD +I Sbjct: 70 GALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLKNQIVRDTDFIIV 129 Query: 117 RENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRA 176 R V + + ++++ A Sbjct: 130 -----------------------QSAKRANDHVDGNISVDDFAQDTITYEQREVEQVITA 166 Query: 177 AIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGEL 221 E A+ R +VT+V + +T + ++A+ + Sbjct: 167 GFERAMNRKR-AVTVVTPFDSF-YTSKIWALTAEKIAKIYPDVVV 209 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 56.6 bits (135), Expect = 6e-07, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 34/72 (47%), Gaps = 9/72 (12%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG +++ ++ K+ +AA I W + + +P++ ++L+R + Sbjct: 36 IGPEISSSVQKIFEAANA-------PIEWDPVDV--TPVKGDDGIFRIPSKCIELMRINK 86 Query: 61 VAIKGPLTTPVG 72 + +KGPL TP Sbjct: 87 IGLKGPLATPNW 98 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 52.7 bits (125), Expect = 1e-05, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 26/61 (42%) Query: 156 EHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGAFKDWGYQLARE 215 E + S++G + +R A + A R VTL++K ++G+ + +L Sbjct: 13 EGVVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLVEAAQRLHCH 72 Query: 216 E 216 Sbjct: 73 Y 73 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 51.9 bits (123), Expect = 1e-05, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 28/69 (40%), Gaps = 5/69 (7%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 +G +V P + V+ A S+ E+ G + + G V LP ETL ++ Sbjct: 51 VGNEVIPVAVDVLCLAGSL---EGIDFSFEELPIGGVALDLVG--VPLPKETLIRAKQSD 105 Query: 61 VAIKGPLTT 69 + G + Sbjct: 106 ALLLGAVGW 114 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 46.2 bits (108), Expect = 9e-04, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 18/33 (54%) Query: 188 SVTLVHKGNIMKFTEGAFKDWGYQLAREEFGGE 220 VT +HK NIMK +G F +LA++ E Sbjct: 79 KVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 45.0 bits (105), Expect = 0.002, Method: Composition-based stats. Identities = 9/43 (20%), Positives = 17/43 (39%), Gaps = 3/43 (6%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYG 43 IG ++ +KV++ A EK + G + +G Sbjct: 20 IGPEIMTEAVKVLELANEK---YQLGFELTHDVIGGAAIDKHG 59 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 43.1 bits (100), Expect = 0.007, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 31/71 (43%), Gaps = 11/71 (15%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYR 60 IG ++T ++ ++ + I W + G+D L + ++ +R R Sbjct: 19 IGNEITDSVKEIFEYVNA-------PIEWEQYNVSG--MSSAGED--LFKQAVESLRRNR 67 Query: 61 VAIKGPLTTPV 71 V +KG L TP+ Sbjct: 68 VGLKGILFTPI 78 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 40.0 bits (92), Expect = 0.067, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 26/75 (34%), Gaps = 8/75 (10%) Query: 1 IGVDVTPAMLKVVDAAVEKAYKGER--KISWMEIYTGEKSTQVYGQDVWLPAETLDLIRE 58 IG + P L+V DAA + + + +G+ P + D +R Sbjct: 14 IGKEAVPERLRVPDAAARRFGFALHCGHFDF----ASSDTRARHGKLR--PDDRFDTLRG 67 Query: 59 YRVAIKGPLTTPVGG 73 Y G + P G Sbjct: 68 YDALFFGAVGRPDTG 82 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.312 0.138 0.385 Lambda K H 0.267 0.0422 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,305,838,549 Number of Sequences: 3077464 Number of extensions: 51334933 Number of successful extensions: 135191 Number of sequences better than 1.0e-01: 203 Number of HSP's better than 0.1 without gapping: 353 Number of HSP's successfully gapped in prelim test: 165 Number of HSP's that attempted gapping in prelim test: 133304 Number of HSP's gapped (non-prelim): 535 length of query: 222 length of database: 1,040,396,356 effective HSP length: 124 effective length of query: 98 effective length of database: 658,790,820 effective search space: 64561500360 effective search space used: 64561500360 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 90 (39.2 bits)