Phyre 2 Results for P0AES0

Phyre Home | Retrieve Phyre Job Id

Email | l.a.kelley@imperial.ac.uk
Description | P0AES0
Date | Thu Jan 5 11:24:04 GMT 2012
Unique Job ID | 733290985eef1a41

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c2ioaA_
Top template information
PDB header:ligase, hydrolase Chain: A: PDB Molecule:bifunctional glutathionylspermidine PDBTitle: e. coli bifunctional glutathionylspermidine2 synthetase/amidase incomplex with mg2+ and adp and3 phosphinate inhibitor
Confidence and coverage
Confidence: | 100.0% | Coverage: | 95%
589 residues ( 95% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | S | K | G | T | T | S | Q | D | A | P | F | G | T | L | L | G | Y | A | P | G | G | V | A | I | Y | S | S | D | Y | S | S | L | D | P | Q | E | Y | E | D | D | A | V | F | R | S | Y | I | D | D | E | Y | M | G | H | K | W | Q | C | V
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | E | F | A | R | R | F | L | F | L | N | Y | G | V | V | F | T | D | V | G | M | A | W | E | I | F | S | L | R | F | L | R | E | V | V | N | D | N | I | L | P | L | Q | A | F | P | N | G | S | P | R | A | P | V | A | G | A | L | L | I | W
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  | ? |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | D | K | G | G | E | F | K | D | T | G | H | V | A | I | I | T | Q | L | H | G | N | K | V | R | I | A | E | Q | N | V | I | H | S | P | L | P | Q | G | Q | Q | W | T | R | E | L | E | M | V | V | E | N | G | C | Y | T | L | K | D | T | F
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | D | D | T | T | I | L | G | W | M | I | Q | T | E | D | T | E | Y | S | L | P | Q | P | E | I | A | G | E | L | L | K | I | S | G | A | R | L | E | N | K | G | Q | F | D | G | K | W | L | D | E | K | D | P | L | Q | N | A | Y | V | Q | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  | ? | ? | ? | ? | ? |  |  | ? | ? |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | N | G | Q | V | I | N | Q | D | P | Y | H | Y | Y | T | I | T | E | S | A | E | Q | E | L | I | K | A | T | N | E | L | H | L | M | Y | L | H | A | T | D | K | V | L | K | D | D | N | L | L | A | L | F | D | I | P | K | I | L | W | P | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | L | R | L | S | W | Q | R | R | R | H | H | M | I | T | G | R | M | D | F | C | M | D | E | R | G | L | K | V | Y | E | Y | N | A | D | S | A | S | C | H | T | E | A | G | L | I | L | E | R | W | A | E | Q | G | Y | K | G | N | G | F | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420
Sequence |  | P | A | E | G | L | I | N | E | L | A | G | A | W | K | H | S | R | A | R | P | F | V | H | I | M | Q | D | K | D | I | E | E | N | Y | H | A | Q | F | M | E | Q | A | L | H | Q | A | G | F | E | T | R | I | L | R | G | L | D | E | L | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480
Sequence |  | W | D | A | A | G | Q | L | I | D | G | E | G | R | L | V | N | C | V | W | K | T | W | A | W | E | T | A | F | D | Q | I | R | E | V | S | D | R | E | F | A | A | V | P | I | R | T | G | H | P | Q | N | E | V | R | L | I | D | V | L | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  | ? | ? | ? |  | ? | ? |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540
Sequence |  | R | P | E | V | L | V | F | E | P | L | W | T | V | I | P | G | N | K | A | I | L | P | I | L | W | S | L | F | P | H | H | R | Y | L | L | D | T | D | F | T | V | N | D | E | L | V | K | T | G | Y | A | V | K | P | I | A | G | R | C | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600
Sequence |  | S | N | I | D | L | V | S | H | H | E | E | V | L | D | K | T | S | G | K | F | A | E | Q | K | N | I | Y | Q | Q | L | W | C | L | P | K | V | D | G | K | Y | I | Q | V | C | T | F | T | V | G | G | N | Y | G | G | T | C | L | R | G | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  | ? | ? |  | ? | ? | ? | ? | ? | ? | ? | ? |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | .
Sequence |  | E | S | L | V | I | K | K | E | S | D | I | E | P | L | I | V | V | K | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c2ioaA_ |

### PDB 2ioa chain A

Region: 10 - 618
Aligned: 589
Modelled: 609
Confidence: 100.0%
Identity: 100%
PDB header:ligase, hydrolase
Chain: A: PDB Molecule:bifunctional glutathionylspermidine
PDBTitle: e. coli bifunctional glutathionylspermidine2 synthetase/amidase incomplex with mg2+ and adp and3 phosphinate inhibitor

Phyre2
2 |
| c2vpmB_ |

### PDB 2vpm chain B

Region: 9 - 616
Aligned: 561
Modelled: 578
Confidence: 100.0%
Identity: 33%
PDB header:ligase
Chain: B: PDB Molecule:trypanothione synthetase;
PDBTitle: trypanothione synthetase

Phyre2
3 |
| d2io8a3 |

### PDB 2io8 chain A domain 3

Region: 201 - 615
Aligned: 297
Modelled: 297
Confidence: 100.0%
Identity: 98%
Fold: ATP-grasp
Superfamily: Glutathione synthetase ATP-binding domain-like
Family: Glutathionylspermidine synthase ATP-binding domain-like

Phyre2
4 |
| d2io8a2 |

### PDB 2io8 chain A domain 2

Region: 10 - 200
Aligned: 183
Modelled: 191
Confidence: 100.0%
Identity: 98%
Fold: Cysteine proteinases
Superfamily: Cysteine proteinases
Family: CHAP domain

Phyre2
5 |
| d2io8a1 |

### PDB 2io8 chain A domain 1

Region: 379 - 510
Aligned: 113
Modelled: 113
Confidence: 100.0%
Identity: 74%
Fold: PreATP-grasp domain
Superfamily: PreATP-grasp domain
Family: Glutathionylspermidine synthase substrate-binding domain-like

Phyre2
6 |
| c3n6xA_ |

### PDB 3n6x chain A

Region: 254 - 609
Aligned: 330
Modelled: 356
Confidence: 99.7%
Identity: 16%
PDB header:ligase
Chain: A: PDB Molecule:putative glutathionylspermidine synthase;
PDBTitle: crystal structure of a putative glutathionylspermidine synthase2 (mfla_0391) from methylobacillus flagellatus kt at 2.35 a resolution

Phyre2
7 |
| c2k3aA_ |

### PDB 2k3a chain A

Region: 14 - 164
Aligned: 127
Modelled: 135
Confidence: 98.6%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:chap domain protein;
PDBTitle: nmr solution structure of staphylococcus saprophyticus chap2 (cysteine, histidine-dependent amidohydrolases/peptidases)3 domain protein. northeast structural genomics consortium4 target syr11

Phyre2
8 |
| c2hgsA_ |

### PDB 2hgs chain A

Region: 255 - 616
Aligned: 330
Modelled: 340
Confidence: 98.4%
Identity: 18%
PDB header:amine/carboxylate ligase
Chain: A: PDB Molecule:protein (glutathione synthetase);
PDBTitle: human glutathione synthetase

Phyre2
9 |
| c3kalB_ |

### PDB 3kal chain B

Region: 255 - 597
Aligned: 309
Modelled: 322
Confidence: 97.8%
Identity: 17%
PDB header:ligase
Chain: B: PDB Molecule:homoglutathione synthetase;
PDBTitle: structure of homoglutathione synthetase from glycine max in2 closed conformation with homoglutathione, adp, a sulfate3 ion, and three magnesium ions bound

Phyre2
10 |
| c1gshA_ |

### PDB 1gsh chain A

Region: 395 - 600
Aligned: 173
Modelled: 183
Confidence: 97.4%
Identity: 14%
PDB header:glutathione biosynthesis ligase
Chain: A: PDB Molecule:glutathione biosynthetic ligase;
PDBTitle: structure of escherichia coli glutathione synthetase at ph 7.5

Phyre2
11 |
| c1pk8D_ |

### PDB 1pk8 chain D

Region: 463 - 615
Aligned: 147
Modelled: 153
Confidence: 97.1%
Identity: 14%
PDB header:membrane protein
Chain: D: PDB Molecule:rat synapsin i;
PDBTitle: crystal structure of rat synapsin i c domain complexed to2 ca.atp

Phyre2
12 |
| c2wyoC_ |

### PDB 2wyo chain C

Region: 255 - 616
Aligned: 317
Modelled: 326
Confidence: 96.9%
Identity: 17%
PDB header:ligase
Chain: C: PDB Molecule:glutathione synthetase;
PDBTitle: trypanosoma brucei glutathione synthetase

Phyre2
13 |
| c2qb5B_ |

### PDB 2qb5 chain B

Region: 375 - 601
Aligned: 194
Modelled: 227
Confidence: 96.9%
Identity: 15%
PDB header:transferase
Chain: B: PDB Molecule:inositol-tetrakisphosphate 1-kinase;
PDBTitle: crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase2 (itpk1) in complex with adp and mn2+

Phyre2
14 |
| c1uc8B_ |

### PDB 1uc8 chain B

Region: 381 - 605
Aligned: 180
Modelled: 199
Confidence: 96.8%
Identity: 16%
PDB header:biosynthetic protein
Chain: B: PDB Molecule:lysine biosynthesis enzyme;
PDBTitle: crystal structure of a lysine biosynthesis enzyme, lysx,2 from thermus thermophilus hb8

Phyre2
15 |
| c2p0aA_ |

### PDB 2p0a chain A

Region: 474 - 609
Aligned: 131
Modelled: 136
Confidence: 96.8%
Identity: 16%
PDB header:neuropeptide
Chain: A: PDB Molecule:synapsin-3;
PDBTitle: the crystal structure of human synapsin iii (syn3) in complex with2 amppnp

Phyre2
16 |
| c1i7nA_ |

### PDB 1i7n chain A

Region: 475 - 609
Aligned: 129
Modelled: 135
Confidence: 96.7%
Identity: 14%
PDB header:neuropeptide
Chain: A: PDB Molecule:synapsin ii;
PDBTitle: crystal structure analysis of the c domain of synapsin ii2 from rat brain

Phyre2
17 |
| c1m0tB_ |

### PDB 1m0t chain B

Region: 255 - 534
Aligned: 251
Modelled: 260
Confidence: 96.3%
Identity: 20%
PDB header:ligase
Chain: B: PDB Molecule:glutathione synthetase;
PDBTitle: yeast glutathione synthase

Phyre2
18 |
| d1pk8a2 |

### PDB 1pk8 chain A domain 2

Region: 488 - 616
Aligned: 124
Modelled: 129
Confidence: 96.1%
Identity: 15%
Fold: ATP-grasp
Superfamily: Glutathione synthetase ATP-binding domain-like
Family: Synapsin C-terminal domain

Phyre2
19 |
| c3t9aA_ |

### PDB 3t9a chain A

Region: 518 - 602
Aligned: 80
Modelled: 85
Confidence: 95.8%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:inositol pyrophosphate kinase;
PDBTitle: crystal structure of the catalytic domain of human diphosphoinositol2 pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp at ph 7.0

Phyre2
20 |
| c3ln6A_ |

### PDB 3ln6 chain A

Region: 492 - 612
Aligned: 108
Modelled: 121
Confidence: 94.7%
Identity: 13%
PDB header:ligase
Chain: A: PDB Molecule:glutathione biosynthesis bifunctional protein gshab;
PDBTitle: crystal structure of a bifunctional glutathione synthetase from2 streptococcus agalactiae

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c2ioaA_ |
|  | 100.0 | 100 | PDB header:ligase, hydrolase Chain: A: PDB Molecule:bifunctional glutathionylspermidine PDBTitle: e. coli bifunctional glutathionylspermidine2 synthetase/amidase incomplex with mg2+ and adp and3 phosphinate inhibitor
2 | c2vpmB_ |
|  | 100.0 | 33 | PDB header:ligase Chain: B: PDB Molecule:trypanothione synthetase; PDBTitle: trypanothione synthetase
3 | d2io8a3 |
|  | 100.0 | 98 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:Glutathionylspermidine synthase ATP-binding domain-like
4 | d2io8a2 |
|  | 100.0 | 98 | Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:CHAP domain
5 | d2io8a1 |
|  | 100.0 | 74 | Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:Glutathionylspermidine synthase substrate-binding domain-like
6 | c3n6xA_ |
|  | 99.7 | 16 | PDB header:ligase Chain: A: PDB Molecule:putative glutathionylspermidine synthase; PDBTitle: crystal structure of a putative glutathionylspermidine synthase2 (mfla_0391) from methylobacillus flagellatus kt at 2.35 a resolution
7 | c2k3aA_ |
|  | 98.6 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:chap domain protein; PDBTitle: nmr solution structure of staphylococcus saprophyticus chap2 (cysteine, histidine-dependent amidohydrolases/peptidases)3 domain protein. northeast structural genomics consortium4 target syr11
8 | c2hgsA_ |
|  | 98.4 | 18 | PDB header:amine/carboxylate ligase Chain: A: PDB Molecule:protein (glutathione synthetase); PDBTitle: human glutathione synthetase
9 | c3kalB_ |
|  | 97.8 | 17 | PDB header:ligase Chain: B: PDB Molecule:homoglutathione synthetase; PDBTitle: structure of homoglutathione synthetase from glycine max in2 closed conformation with homoglutathione, adp, a sulfate3 ion, and three magnesium ions bound
10 | c1gshA_ |
|  | 97.4 | 14 | PDB header:glutathione biosynthesis ligase Chain: A: PDB Molecule:glutathione biosynthetic ligase; PDBTitle: structure of escherichia coli glutathione synthetase at ph 7.5
11 | c1pk8D_ |
|  | 97.1 | 14 | PDB header:membrane protein Chain: D: PDB Molecule:rat synapsin i; PDBTitle: crystal structure of rat synapsin i c domain complexed to2 ca.atp
12 | c2wyoC_ |
|  | 96.9 | 17 | PDB header:ligase Chain: C: PDB Molecule:glutathione synthetase; PDBTitle: trypanosoma brucei glutathione synthetase
13 | c2qb5B_ |
|  | 96.9 | 15 | PDB header:transferase Chain: B: PDB Molecule:inositol-tetrakisphosphate 1-kinase; PDBTitle: crystal structure of human inositol 1,3,4-trisphosphate 5/6-kinase2 (itpk1) in complex with adp and mn2+
14 | c1uc8B_ |
|  | 96.8 | 16 | PDB header:biosynthetic protein Chain: B: PDB Molecule:lysine biosynthesis enzyme; PDBTitle: crystal structure of a lysine biosynthesis enzyme, lysx,2 from thermus thermophilus hb8
15 | c2p0aA_ |
|  | 96.8 | 16 | PDB header:neuropeptide Chain: A: PDB Molecule:synapsin-3; PDBTitle: the crystal structure of human synapsin iii (syn3) in complex with2 amppnp
16 | c1i7nA_ |
|  | 96.7 | 14 | PDB header:neuropeptide Chain: A: PDB Molecule:synapsin ii; PDBTitle: crystal structure analysis of the c domain of synapsin ii2 from rat brain
17 | c1m0tB_ |
|  | 96.3 | 20 | PDB header:ligase Chain: B: PDB Molecule:glutathione synthetase; PDBTitle: yeast glutathione synthase
18 | d1pk8a2 |
|  | 96.1 | 15 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:Synapsin C-terminal domain
19 | c3t9aA_ |
|  | 95.8 | 21 | PDB header:transferase Chain: A: PDB Molecule:inositol pyrophosphate kinase; PDBTitle: crystal structure of the catalytic domain of human diphosphoinositol2 pentakisphosphate kinase 2 (ppip5k2) in complex with amppnp at ph 7.0
20 | c3ln6A_ |
|  | 94.7 | 13 | PDB header:ligase Chain: A: PDB Molecule:glutathione biosynthesis bifunctional protein gshab; PDBTitle: crystal structure of a bifunctional glutathione synthetase from2 streptococcus agalactiae
21 | d1i7na2 |
| not modelled | 94.4 | 15 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:Synapsin C-terminal domain
22 | d1gsaa2 |
| not modelled | 93.6 | 20 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:ATP-binding domain of peptide synthetases
23 | c3ln7A_ |
| not modelled | 93.0 | 14 | PDB header:ligase Chain: A: PDB Molecule:glutathione biosynthesis bifunctional protein gshab; PDBTitle: crystal structure of a bifunctional glutathione synthetase from2 pasteurella multocida
24 | c3bg5C_ |
| not modelled | 90.5 | 18 | PDB header:ligase Chain: C: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of staphylococcus aureus pyruvate2 carboxylase
25 | c3lp8A_ |
| not modelled | 89.7 | 25 | PDB header:ligase Chain: A: PDB Molecule:phosphoribosylamine-glycine ligase; PDBTitle: crystal structure of phosphoribosylamine-glycine ligase from2 ehrlichia chaffeensis
26 | c1kjjA_ |
| not modelled | 89.4 | 12 | PDB header:transferase Chain: A: PDB Molecule:phosphoribosylglycinamide formyltransferase 2; PDBTitle: crystal structure of glycniamide ribonucleotide2 transformylase in complex with mg-atp-gamma-s
27 | c2yyaB_ |
| not modelled | 89.2 | 20 | PDB header:ligase Chain: B: PDB Molecule:phosphoribosylamine--glycine ligase; PDBTitle: crystal structure of gar synthetase from aquifex aeolicus
28 | c1vkzA_ |
| not modelled | 88.5 | 14 | PDB header:ligase Chain: A: PDB Molecule:phosphoribosylamine--glycine ligase; PDBTitle: crystal structure of phosphoribosylamine--glycine ligase (tm1250) from2 thermotoga maritima at 2.30 a resolution
29 | c2hjwA_ |
| not modelled | 88.0 | 17 | PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: crystal structure of the bc domain of acc2
30 | c2xd4A_ |
| not modelled | 87.7 | 19 | PDB header:ligase Chain: A: PDB Molecule:phosphoribosylamine--glycine ligase; PDBTitle: nucleotide-bound structures of bacillus subtilis glycinamide2 ribonucleotide synthetase
31 | d2if6a1 |
| not modelled | 87.4 | 17 | Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:YiiX-like
32 | c1ulzA_ |
| not modelled | 87.0 | 14 | PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase n-terminal domain; PDBTitle: crystal structure of the biotin carboxylase subunit of pyruvate2 carboxylase
33 | c2i80B_ |
| not modelled | 86.9 | 18 | PDB header:ligase Chain: B: PDB Molecule:d-alanine-d-alanine ligase; PDBTitle: allosteric inhibition of staphylococcus aureus d-alanine:d-alanine2 ligase revealed by crystallographic studies
34 | c2ip4A_ |
| not modelled | 86.2 | 18 | PDB header:ligase Chain: A: PDB Molecule:phosphoribosylamine--glycine ligase; PDBTitle: crystal structure of glycinamide ribonucleotide synthetase from2 thermus thermophilus hb8
35 | c3tinA_ |
| not modelled | 86.1 | 12 | PDB header:ligase Chain: A: PDB Molecule:ttl protein; PDBTitle: tubulin tyrosine ligase
36 | c1ehiB_ |
| not modelled | 85.2 | 20 | PDB header:ligase Chain: B: PDB Molecule:d-alanine:d-lactate ligase; PDBTitle: d-alanine:d-lactate ligase (lmddl2) of vancomycin-resistant2 leuconostoc mesenteroides
37 | c2dzdB_ |
| not modelled | 84.3 | 12 | PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of the biotin carboxylase domain of2 pyruvate carboxylase
38 | c2vpqA_ |
| not modelled | 84.0 | 12 | PDB header:ligase Chain: A: PDB Molecule:acetyl-coa carboxylase; PDBTitle: crystal structure of biotin carboxylase from s. aureus2 complexed with amppnp
39 | c3se7A_ |
| not modelled | 83.6 | 19 | PDB header:ligase Chain: A: PDB Molecule:vana; PDBTitle: ancient vana
40 | c3gidB_ |
| not modelled | 81.8 | 13 | PDB header:ligase Chain: B: PDB Molecule:acetyl-coa carboxylase 2; PDBTitle: the biotin carboxylase (bc) domain of human acetyl-coa2 carboxylase 2 (acc2) in complex with soraphen a
41 | c2dlnA_ |
| not modelled | 81.8 | 23 | PDB header:ligase(peptidoglycan synthesis) Chain: A: PDB Molecule:d-alanine--d-alanine ligase; PDBTitle: vancomycin resistance: structure of d-alanine:d-alanine2 ligase at 2.3 angstroms resolution
42 | c2pvpB_ |
| not modelled | 81.7 | 19 | PDB header:ligase Chain: B: PDB Molecule:d-alanine-d-alanine ligase; PDBTitle: crystal structure of d-alanine-d-alanine ligase from helicobacter2 pylori
43 | c3tqtB_ |
| not modelled | 80.7 | 16 | PDB header:ligase Chain: B: PDB Molecule:d-alanine--d-alanine ligase; PDBTitle: structure of the d-alanine-d-alanine ligase from coxiella burnetii
44 | c3ouzA_ |
| not modelled | 80.2 | 10 | PDB header:ligase Chain: A: PDB Molecule:biotin carboxylase; PDBTitle: crystal structure of biotin carboxylase-adp complex from campylobacter2 jejuni
45 | c3g8cB_ |
| not modelled | 79.7 | 14 | PDB header:ligase Chain: B: PDB Molecule:biotin carboxylase; PDBTitle: crystal stucture of biotin carboxylase in complex with2 biotin, bicarbonate, adp and mg ion
46 | c3lwbA_ |
| not modelled | 78.5 | 22 | PDB header:ligase Chain: A: PDB Molecule:d-alanine--d-alanine ligase; PDBTitle: crystal structure of apo d-alanine:d-alanine ligase (ddl) from2 mycobacterium tuberculosis
47 | d1gsaa1 |
| not modelled | 78.3 | 11 | Fold:PreATP-grasp domain Superfamily:PreATP-grasp domain Family:Prokaryotic glutathione synthetase, N-terminal domain
48 | d3etja3 |
| not modelled | 76.6 | 16 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
49 | d1e4ea2 |
| not modelled | 75.3 | 13 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:ATP-binding domain of peptide synthetases
50 | c2zdqA_ |
| not modelled | 75.3 | 10 | PDB header:ligase Chain: A: PDB Molecule:d-alanine--d-alanine ligase; PDBTitle: crystal structure of d-alanine:d-alanine ligase with atp2 and d-alanine:d-alanine from thermus thermophius hb8
51 | c3r23B_ |
| not modelled | 75.0 | 16 | PDB header:ligase Chain: B: PDB Molecule:d-alanine--d-alanine ligase; PDBTitle: crystal structure of d-alanine--d-alanine ligase from bacillus2 anthracis
52 | d1uc8a2 |
| not modelled | 74.8 | 27 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:Lysine biosynthesis enzyme LysX ATP-binding domain
53 | d1fs2b1 |
| not modelled | 74.6 | 20 | Fold:Skp1 dimerisation domain-like Superfamily:Skp1 dimerisation domain-like Family:Skp1 dimerisation domain-like
54 | d1gsoa3 |
| not modelled | 74.0 | 30 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
55 | c1w96B_ |
| not modelled | 72.8 | 20 | PDB header:ligase Chain: B: PDB Molecule:acetyl-coenzyme a carboxylase; PDBTitle: crystal structure of biotin carboxylase domain of acetyl-2 coenzyme a carboxylase from saccharomyces cerevisiae in3 complex with soraphen a
56 | c2k1gA_ |
| not modelled | 72.7 | 22 | PDB header:lipoprotein Chain: A: PDB Molecule:lipoprotein spr; PDBTitle: solution nmr structure of lipoprotein spr from escherichia coli k12.2 northeast structural genomics target er541-37-162
57 | c3i12A_ |
| not modelled | 72.5 | 11 | PDB header:ligase Chain: A: PDB Molecule:d-alanine-d-alanine ligase a; PDBTitle: the crystal structure of the d-alanyl-alanine synthetase a from2 salmonella enterica subsp. enterica serovar typhimurium str. lt2
58 | d1iowa2 |
| not modelled | 71.6 | 24 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:ATP-binding domain of peptide synthetases
59 | c3e5nA_ |
| not modelled | 71.1 | 25 | PDB header:ligase Chain: A: PDB Molecule:d-alanine-d-alanine ligase a; PDBTitle: crystal strucutre of d-alanine-d-alanine ligase from2 xanthomonas oryzae pv. oryzae kacc10331
60 | d1kjqa3 |
| not modelled | 69.8 | 5 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
61 | d1ehia2 |
| not modelled | 69.6 | 24 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:ATP-binding domain of peptide synthetases
62 | d2j9ga3 |
| not modelled | 68.0 | 20 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
63 | c3kw0D_ |
| not modelled | 67.0 | 33 | PDB header:hydrolase Chain: D: PDB Molecule:cysteine peptidase; PDBTitle: crystal structure of cysteine peptidase (np_982244.1) from bacillus2 cereus atcc 10987 at 2.50 a resolution
64 | c3df7A_ |
| not modelled | 64.5 | 14 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative atp-grasp superfamily protein; PDBTitle: crystal structure of a putative atp-grasp superfamily2 protein from archaeoglobus fulgidus
65 | c1e4eB_ |
| not modelled | 64.5 | 13 | PDB header:ligase Chain: B: PDB Molecule:vancomycin/teicoplanin a-type resistance protein vana; PDBTitle: d-alanyl-d-lacate ligase
66 | d1vkza3 |
| not modelled | 63.6 | 17 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
67 | d1w96a3 |
| not modelled | 62.8 | 13 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
68 | c2cqyA_ |
| not modelled | 60.6 | 16 | PDB header:ligase Chain: A: PDB Molecule:propionyl-coa carboxylase alpha chain, PDBTitle: solution structure of b domain from human propionyl-coa2 carboxylase alpha subunit
69 | c2gpwC_ |
| not modelled | 59.8 | 13 | PDB header:ligase Chain: C: PDB Molecule:biotin carboxylase; PDBTitle: crystal structure of the biotin carboxylase subunit, f363a2 mutant, of acetyl-coa carboxylase from escherichia coli.
70 | c3pbiA_ |
| not modelled | 59.3 | 27 | PDB header:hydrolase Chain: A: PDB Molecule:invasion protein; PDBTitle: structure of the peptidoglycan hydrolase ripb (rv1478) from2 mycobacterium tuberculosis at 1.6 resolution
71 | c3k3pA_ |
| not modelled | 58.6 | 18 | PDB header:ligase Chain: A: PDB Molecule:d-alanine--d-alanine ligase; PDBTitle: crystal structure of the apo form of d-alanine:d-alanine ligase (ddl)2 from streptococcus mutans
72 | d2evra2 |
| not modelled | 58.4 | 27 | Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:NlpC/P60
73 | c3orqA_ |
| not modelled | 55.0 | 8 | PDB header:ligase,biosynthetic protein Chain: A: PDB Molecule:n5-carboxyaminoimidazole ribonucleotide synthetase; PDBTitle: crystal structure of n5-carboxyaminoimidazole synthetase from2 staphylococcus aureus complexed with adp
74 | d1nexa1 |
| not modelled | 53.3 | 19 | Fold:Skp1 dimerisation domain-like Superfamily:Skp1 dimerisation domain-like Family:Skp1 dimerisation domain-like
75 | d1a9xa6 |
| not modelled | 51.3 | 8 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
76 | d1vbva1 |
| not modelled | 49.3 | 23 | Fold:SH3-like barrel Superfamily:YccV-like Family:YccV-like
77 | d2ovra1 |
| not modelled | 49.0 | 21 | Fold:Skp1 dimerisation domain-like Superfamily:Skp1 dimerisation domain-like Family:Skp1 dimerisation domain-like
78 | c2ys6A_ |
| not modelled | 47.1 | 35 | PDB header:ligase Chain: A: PDB Molecule:phosphoribosylglycinamide synthetase; PDBTitle: crystal structure of gar synthetase from geobacillus kaustophilus
79 | c2fg0B_ |
| not modelled | 46.6 | 29 | PDB header:hydrolase Chain: B: PDB Molecule:cog0791: cell wall-associated hydrolases (invasion- PDBTitle: crystal structure of a putative gamma-d-glutamyl-l-diamino acid2 endopeptidase (npun_r0659) from nostoc punctiforme pcc 73102 at 1.793 a resolution
80 | c2p1nD_ |
| not modelled | 45.5 | 24 | PDB header:signaling protein Chain: D: PDB Molecule:skp1-like protein 1a; PDBTitle: mechanism of auxin perception by the tir1 ubiqutin ligase
81 | c1z2pX_ |
| not modelled | 45.0 | 19 | PDB header:transferase Chain: X: PDB Molecule:inositol 1,3,4-trisphosphate 5/6-kinase; PDBTitle: inositol 1,3,4-trisphosphate 5/6-kinase in complex with mg2+/amp-2 pcp/ins(1,3,4)p3
82 | d1a9xa5 |
| not modelled | 42.0 | 8 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
83 | c1nexC_ |
| not modelled | 42.0 | 18 | PDB header:ligase, cell cycle Chain: C: PDB Molecule:centromere dna-binding protein complex cbf3 PDBTitle: crystal structure of scskp1-sccdc4-cpd peptide complex
84 | c3s4wB_ |
| not modelled | 40.9 | 32 | PDB header:dna binding protein Chain: B: PDB Molecule:fanconi anemia group d2 protein homolog; PDBTitle: structure of the fanci-fancd2 complex
85 | c2dwcB_ |
| not modelled | 40.7 | 4 | PDB header:transferase Chain: B: PDB Molecule:433aa long hypothetical phosphoribosylglycinamide formyl PDBTitle: crystal structure of probable phosphoribosylglycinamide formyl2 transferase from pyrococcus horikoshii ot3 complexed with adp
86 | d2hgsa4 |
| not modelled | 40.3 | 19 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:Eukaryotic glutathione synthetase ATP-binding domain
87 | c3n6rK_ |
| not modelled | 39.6 | 25 | PDB header:ligase Chain: K: PDB Molecule:propionyl-coa carboxylase, alpha subunit; PDBTitle: crystal structure of the holoenzyme of propionyl-coa carboxylase (pcc)
88 | c3i86A_ |
| not modelled | 39.2 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the p60 domain from m. avium subspecies2 paratuberculosis antigen map1204
89 | d2auaa1 |
| not modelled | 38.0 | 40 | Fold:ADP-ribosylation Superfamily:ADP-ribosylation Family:BC2332-like
90 | d1irza_ |
| not modelled | 37.8 | 27 | Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:GARP response regulators
91 | c2xivA_ |
| not modelled | 36.8 | 18 | PDB header:structural protein Chain: A: PDB Molecule:hypothetical invasion protein; PDBTitle: structure of rv1477, hypothetical invasion protein of2 mycobacterium tuberculosis
92 | d2r85a2 |
| not modelled | 35.5 | 13 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:PurP ATP-binding domain-like
93 | c3gt2A_ |
| not modelled | 34.6 | 19 | PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of the p60 domain from m. avium2 paratuberculosis antigen map1272c
94 | c1gsoA_ |
| not modelled | 32.4 | 33 | PDB header:ligase Chain: A: PDB Molecule:protein (glycinamide ribonucleotide synthetase); PDBTitle: glycinamide ribonucleotide synthetase (gar-syn) from e.2 coli.
95 | c3al6A_ |
| not modelled | 32.1 | 10 | PDB header:unknown function Chain: A: PDB Molecule:jmjc domain-containing protein c2orf60; PDBTitle: crystal structure of human tyw5
96 | d2r7ka2 |
| not modelled | 32.0 | 21 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:PurP ATP-binding domain-like
97 | d2oo3a1 |
| not modelled | 31.8 | 19 | Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:LPG1296-like
98 | c3kopB_ |
| not modelled | 30.9 | 17 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein with a cyclophilin-like fold2 (yp_831253.1) from arthrobacter sp. fb24 at 1.90 a resolution
99 | c2qk4A_ |
| not modelled | 30.7 | 26 | PDB header:ligase Chain: A: PDB Molecule:trifunctional purine biosynthetic protein adenosine-3; PDBTitle: human glycinamide ribonucleotide synthetase
100 | c3h41A_ |
| not modelled | 28.8 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:nlp/p60 family protein; PDBTitle: crystal structure of a nlpc/p60 family protein (bce_2878) from2 bacillus cereus atcc 10987 at 1.79 a resolution
101 | d1saza1 |
| not modelled | 27.0 | 18 | Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Acetokinase-like
102 | c3etjB_ |
| not modelled | 26.2 | 16 | PDB header:lyase Chain: B: PDB Molecule:phosphoribosylaminoimidazole carboxylase atpase PDBTitle: crystal structure e. coli purk in complex with mg, adp, and2 pi
103 | d1vlya1 |
| not modelled | 25.2 | 27 | Fold:Elongation factor/aminomethyltransferase common domain Superfamily:Aminomethyltransferase beta-barrel domain Family:Aminomethyltransferase beta-barrel domain
104 | c3heiI_ |
| not modelled | 25.0 | 18 | PDB header:transferase/signaling protein Chain: I: PDB Molecule:ephrin type-a receptor 2; PDBTitle: ligand recognition by a-class eph receptors: crystal structures of the2 epha2 ligand-binding domain and the epha2/ephrin-a1 complex
105 | d1ulza3 |
| not modelled | 24.0 | 21 | Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:BC ATP-binding domain-like
106 | c3q2oB_ |
| not modelled | 24.0 | 5 | PDB header:lyase Chain: B: PDB Molecule:phosphoribosylaminoimidazole carboxylase, atpase subunit; PDBTitle: crystal structure of purk: n5-carboxyaminoimidazole ribonucleotide2 synthetase
107 | c2kytA_ |
| not modelled | 23.8 | 35 | PDB header:hydrolase Chain: A: PDB Molecule:group xvi phospholipase a2; PDBTitle: solution struture of the h-rev107 n-terminal domain
108 | d1t3da_ |
| not modelled | 23.6 | 15 | Fold:Single-stranded left-handed beta-helix Superfamily:Trimeric LpxA-like enzymes Family:Serine acetyltransferase
109 | c2z04A_ |
| not modelled | 23.6 | 10 | PDB header:lyase Chain: A: PDB Molecule:phosphoribosylaminoimidazole carboxylase atpase PDBTitle: crystal structure of phosphoribosylaminoimidazole2 carboxylase atpase subunit from aquifex aeolicus
110 | c3kvpB_ |
| not modelled | 23.6 | 57 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein ymzc; PDBTitle: crystal structure of uncharacterized protein ymzc precursor2 from bacillus subtilis, northeast structural genomics3 consortium target sr378a
111 | c2pn1A_ |
| not modelled | 22.8 | 9 | PDB header:ligase Chain: A: PDB Molecule:carbamoylphosphate synthase large subunit; PDBTitle: crystal structure of carbamoylphosphate synthase large subunit (split2 gene in mj) (zp_00538348.1) from exiguobacterium sp. 255-15 at 2.00 a3 resolution
112 | c2ovqA_ |
| not modelled | 21.5 | 21 | PDB header:transcription/cell cycle Chain: A: PDB Molecule:s-phase kinase-associated protein 1a; PDBTitle: structure of the skp1-fbw7-cyclinedegc complex
113 | c2p1gA_ |
| not modelled | 20.6 | 14 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative xylanase; PDBTitle: crystal structure of a putative xylanase from bacteroides fragilis

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0