BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (159 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteria... 333 1e-90 UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobact... 303 1e-81 UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales ... 181 5e-45 UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobact... 175 4e-43 UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicade... 175 4e-43 UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteoba... 166 3e-40 UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacte... 162 3e-39 UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobact... 160 2e-38 UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=... 156 2e-37 UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05... 155 4e-37 UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae ... 152 4e-36 UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatu... 151 7e-36 UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia ... 151 8e-36 UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacte... 149 3e-35 UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidic... 148 5e-35 UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepI... 146 2e-34 UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae ... 145 3e-34 UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria ... 144 9e-34 UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorifti... 144 1e-33 UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacte... 143 2e-33 UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacte... 143 2e-33 UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium... 142 4e-33 UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD 142 5e-33 UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burneti... 140 9e-33 UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri... 138 6e-32 UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacill... 137 1e-31 UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria R... 137 1e-31 UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp... 137 2e-31 UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D... 136 2e-31 UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q... 134 8e-31 UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pin... 133 2e-30 UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria R... 133 2e-30 UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesic... 132 4e-30 UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD 131 6e-30 UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadacea... 130 1e-29 UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria ... 130 2e-29 UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacter... 130 2e-29 UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q... 129 2e-29 UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria ... 129 3e-29 UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q... 128 5e-29 UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobact... 128 6e-29 UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methyloph... 128 6e-29 UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=... 127 9e-29 UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobia... 127 1e-28 UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobact... 126 2e-28 UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm... 126 2e-28 UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteob... 126 2e-28 UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella ... 126 3e-28 UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanth... 125 3e-28 UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=... 125 3e-28 UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris ... 124 8e-28 UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium ... 124 9e-28 UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved... 124 1e-27 UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas su... 124 1e-27 UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter... 124 1e-27 UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter no... 123 2e-27 UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistip... 123 2e-27 UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 123 2e-27 UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiace... 122 4e-27 UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae R... 122 5e-27 UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes R... 121 9e-27 UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2 120 1e-26 UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=D... 120 1e-26 UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatu... 120 1e-26 UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica... 120 1e-26 UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales... 120 2e-26 UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perf... 119 3e-26 UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax parad... 119 3e-26 UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin5... 118 6e-26 UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organi... 118 7e-26 UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6 118 7e-26 UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus rube... 118 7e-26 UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella Rep... 117 1e-25 UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepI... 117 1e-25 UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobi... 117 1e-25 UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mult... 117 2e-25 UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroco... 116 2e-25 UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accum... 116 2e-25 UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula mar... 116 3e-25 UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 115 4e-25 UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepI... 114 8e-25 UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staley... 114 1e-24 UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni ... 114 1e-24 UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopisc... 113 2e-24 UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae... 113 2e-24 UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacte... 113 2e-24 UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm... 112 3e-24 UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lit... 112 3e-24 UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muci... 112 3e-24 UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococ... 112 5e-24 UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perf... 111 6e-24 UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C... 111 7e-24 UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Ba... 111 8e-24 UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium j... 110 1e-23 UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepI... 110 1e-23 UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xen... 110 2e-23 UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloac... 110 2e-23 UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter Rep... 110 2e-23 UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepI... 110 2e-23 UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchi... 109 2e-23 UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q... 109 3e-23 UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomi... 108 4e-23 UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus ... 108 5e-23 UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=D... 108 5e-23 UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. ... 108 5e-23 UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 108 7e-23 UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp.... 107 1e-22 UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio ac... 107 1e-22 UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter... 107 2e-22 UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus Re... 106 2e-22 UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium ... 106 3e-22 UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. ... 106 3e-22 UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium Rep... 106 3e-22 UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolys... 106 3e-22 UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candida... 106 3e-22 UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidat... 105 3e-22 UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria ... 105 4e-22 UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gam... 105 4e-22 UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A... 105 4e-22 UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas ue... 105 5e-22 UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbi... 105 5e-22 UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae... 104 1e-21 UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonel... 104 1e-21 UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniob... 103 2e-21 UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succ... 103 2e-21 UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepI... 103 3e-21 UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C... 102 3e-21 UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales... 102 6e-21 UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus R... 101 9e-21 UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonel... 100 1e-20 UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptoba... 100 1e-20 UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus ... 100 2e-20 UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales R... 100 2e-20 UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium ... 100 2e-20 UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae R... 100 2e-20 UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus R... 100 2e-20 UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobac... 100 3e-20 UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepI... 99 5e-20 UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stella... 99 5e-20 UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacte... 99 6e-20 UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp.... 99 6e-20 UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacter... 99 6e-20 UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organis... 98 8e-20 UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula b... 98 1e-19 UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organis... 97 1e-19 UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira h... 97 1e-19 UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate... 97 2e-19 UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID... 97 2e-19 UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepI... 97 3e-19 UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales ... 96 3e-19 UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacte... 96 4e-19 UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebac... 96 5e-19 UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus Re... 96 5e-19 UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus Re... 95 6e-19 UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales ... 95 6e-19 UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus Re... 95 7e-19 UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus R... 94 1e-18 UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocace... 94 1e-18 UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria R... 94 1e-18 UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobact... 94 2e-18 UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena tu... 94 2e-18 UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus Re... 94 2e-18 UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus fa... 94 2e-18 UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuring... 93 2e-18 UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter form... 93 3e-18 UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berge... 93 3e-18 UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri... 93 3e-18 UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fae... 93 3e-18 UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate red... 93 3e-18 UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostri... 92 4e-18 UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=... 92 5e-18 UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales Re... 92 5e-18 UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azoba... 92 6e-18 UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacte... 92 8e-18 UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (... 92 8e-18 UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae... 91 8e-18 UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus Re... 91 1e-17 UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmone... 91 2e-17 UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales... 91 2e-17 UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria... 91 2e-17 UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lito... 90 2e-17 UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales... 90 2e-17 UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales ... 90 3e-17 UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus Re... 89 3e-17 UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus... 89 4e-17 UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q... 89 4e-17 UniRef50_B3FJX9 Dihydrofolate reductase n=1 Tax=Pseudomonas phag... 89 6e-17 UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q... 88 1e-16 UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus Re... 87 2e-16 UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix r... 87 2e-16 UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium v... 87 2e-16 UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrif... 86 3e-16 UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cav... 86 3e-16 UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadacea... 86 4e-16 UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales ... 86 4e-16 UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium ... 86 4e-16 UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saph... 86 5e-16 UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root R... 86 5e-16 UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas... 85 7e-16 UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetr... 85 8e-16 UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase ... 85 8e-16 UniRef50_Q7NHQ9 Dihydrofolate reductase n=1 Tax=Gloeobacter viol... 84 1e-15 UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID... 84 2e-15 UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phyto... 84 2e-15 UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marin... 84 2e-15 UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim res... 84 2e-15 UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reduc... 84 2e-15 UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi... 84 2e-15 UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentispha... 83 3e-15 UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcacea... 83 3e-15 UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea vi... 82 5e-15 UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium ... 82 5e-15 UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cell... 82 5e-15 UniRef50_D0NVQ6 Putative uncharacterized protein n=1 Tax=Phytoph... 82 5e-15 UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella parame... 82 5e-15 UniRef50_C7P3D4 Dihydrofolate reductase region n=1 Tax=Halomicro... 82 6e-15 UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherich... 82 6e-15 UniRef50_C2CWT0 Dihydrofolate reductase n=1 Tax=Gardnerella vagi... 81 1e-14 UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilagin... 80 2e-14 UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinom... 80 2e-14 UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichop... 80 2e-14 UniRef50_Q6BTR6 DEHA2C16456p n=2 Tax=Debaryomyces hansenii RepID... 80 2e-14 UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimo... 79 3e-14 UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae Re... 79 4e-14 UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax... 79 4e-14 UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX6... 79 4e-14 UniRef50_C3JYD2 Putative dihydrofolate reductase n=1 Tax=Pseudom... 79 4e-14 UniRef50_D0WS26 Dihydrofolate reductase n=1 Tax=Actinomyces sp. ... 79 4e-14 UniRef50_B9YC91 Putative uncharacterized protein n=1 Tax=Holdema... 79 5e-14 UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus co... 79 6e-14 UniRef50_Q96V60 Dihydrofolate reductase (Fragment) n=2 Tax=Pneum... 79 7e-14 UniRef50_C4G1L6 Putative uncharacterized protein n=1 Tax=Abiotro... 78 8e-14 UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mult... 78 9e-14 UniRef50_Q937I9 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q... 78 1e-13 UniRef50_Q0FG98 Dihydrofolate reductase n=1 Tax=Rhodobacterales ... 78 1e-13 UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria... 77 1e-13 UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacte... 77 1e-13 UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis Re... 77 2e-13 UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=... 77 2e-13 UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure... 77 2e-13 UniRef50_C2KQT3 Possible dihydrofolate reductase n=2 Tax=Mobilun... 76 4e-13 UniRef50_C4LHD2 Bifunctional dihydrofolate reductase-thymidylate... 75 6e-13 UniRef50_P0ABQ7 Dihydrofolate reductase type 8 n=2 Tax=Enterobac... 75 7e-13 UniRef50_Q8SDF8 PHIKZ004 n=1 Tax=Pseudomonas phage phiKZ RepID=Q... 75 1e-12 UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cell... 74 1e-12 UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis... 74 1e-12 UniRef50_Q5V3R2 Dihydrofolate reductase 1 n=1 Tax=Haloarcula mar... 74 1e-12 UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepI... 74 2e-12 UniRef50_C0VSW2 Dihydrofolate reductase n=2 Tax=Corynebacterium ... 74 2e-12 UniRef50_Q6F181 Dihydrofolate reductase n=1 Tax=Mesoplasma floru... 73 2e-12 >UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteriaceae RepID=DYR_ECOL6 Length = 159 Score = 333 bits (853), Expect = 1e-90, Method: Compositional matrix adjust. Identities = 159/159 (100%), Positives = 159/159 (100%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI Sbjct: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE Sbjct: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 >UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobacteria RepID=DYR_KLEAE Length = 159 Score = 303 bits (777), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 142/159 (89%), Positives = 152/159 (95%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAAL VDRVIGMENAMPWNL DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI Sbjct: 1 MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE Sbjct: 61 VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159 >UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO Length = 166 Score = 181 bits (460), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 86/162 (53%), Positives = 118/162 (72%), Gaps = 5/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+ Sbjct: 3 ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62 Query: 62 LSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 LS + D +V WV V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ Sbjct: 63 LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122 Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGDT+FPDY + DW+ + + AD +NSH++ I +R Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164 >UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobacteria RepID=DYR_HAEIN Length = 160 Score = 175 bits (444), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 84/158 (53%), Positives = 107/158 (67%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 SLI A ++ VIG +N MPW+LPADLAWF++NT KPVIMGR T+ESIGRPLP R NI+ Sbjct: 3 FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 LS Q + V W S + A+ D EIM+IGGG +++Q+LPKA KLYLT I E++G Sbjct: 63 LSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDG 122 Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DT FP ++WE F E+ AD QN + F IL R+ Sbjct: 123 DTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160 >UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc (Homalodisca coagulata) RepID=Q1LSS4_BAUCH Length = 165 Score = 175 bits (444), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+ VDR+IG++N MPW+L DL WFK++T NKPVIMGR T+++I +PL GR NI Sbjct: 2 IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61 Query: 61 ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +LS P D + WV + +A+ A G+V E+MVIGG ++Y F+ +A +LYLTHID Sbjct: 62 VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++GDT FP Y + W F ++H+ +N Y FEILER Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161 >UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria RepID=DYR3_SALTY Length = 162 Score = 166 bits (419), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAALA + +IG +N +PW+LPADL FK TL KPV+MGR T+ESIGRPLPGR+N+ Sbjct: 2 LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S P + V S+D A+A D E M+IGGG++Y + LP+A +LYLT+IDA++ Sbjct: 62 VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDY W+ + H AD +NS++ F L R+ Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161 >UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=D0KZ69_HALNC Length = 177 Score = 162 bits (410), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+AAL ++VIG NA+PW+LPADL FK+ T+ KP+IMGR T++SIGRPLPGRKNI+ Sbjct: 3 IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 +S P D VT V S+D A+ A PE+MVIGG +Y QFLP+A +LY T + + Sbjct: 63 ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD FP Y DW V E H ADA N Y F +R Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161 >UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobacteria RepID=Q15PF1_PSEA6 Length = 171 Score = 160 bits (404), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 83/168 (49%), Positives = 110/168 (65%), Gaps = 11/168 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+++AA+A RVIG+ N MPW++PADL FKR TL KP++MGR T+ESIGR LPGR NI+ Sbjct: 4 IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63 Query: 62 LSS-QPGTDDRVTWVKSVDEAIAACGD------VP----EIMVIGGGRVYEQFLPKAQKL 110 ++S Q + V S ++AIA +P E+MVIGGG VY+ FLP A +L Sbjct: 64 ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 YLT ID + GDT+FP+Y W+ + SE +D D +N HSY F L R Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171 >UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR Length = 175 Score = 156 bits (394), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 74/160 (46%), Positives = 113/160 (70%), Gaps = 2/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+IAA+ R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+ Sbjct: 14 ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73 Query: 61 ILSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ + V S +EA+ +C EI+++GGG++Y Q +P A KLY+T +DAEV Sbjct: 74 VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP++ D+W+ + E+HD D ++++++ F L R+ Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK 173 >UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium RepID=D0U4K0_9GAMM Length = 179 Score = 155 bits (392), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ +++IG NA+PW+LPADL +FK+ T K V+MGR T+ESIGRPLP R+N+I Sbjct: 21 LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S+D A+ D E+MV+GG YEQ LP +LY+T I+ E + Sbjct: 81 VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD HFP ++ + V E H AD +N ++Y F IL+R Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178 >UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2 Length = 162 Score = 152 bits (384), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII Sbjct: 3 ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS + ++ +A + EIMVIGGG +++Q +P+A +LYLT I AE Sbjct: 63 LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +EGDT F +++ +W V ++ + D QN++ F ILER+ Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162 >UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia pennsylvanicus str. BPEN RepID=Q494F1_BLOPB Length = 164 Score = 151 bits (382), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 76/162 (46%), Positives = 107/162 (66%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 +ISLIAAL + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL R N Sbjct: 2 IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID-- 116 I+LS + + V +++DEA++ D E+MVIGG +Y FLP+AQ+LYLT+I Sbjct: 62 IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E++GD FPDY+ +W+S+F+ F+ F ILER Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163 >UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D3H9_WIGBR Length = 162 Score = 151 bits (381), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A + ++VIG + +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL R NI+ Sbjct: 3 ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + + K+ +A+ + E+M+IGG ++Y+ FLPKA KLYLT I+AE+ Sbjct: 63 LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 G+ FP Y W F ++ ++D +N +S F I + Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161 >UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacteria RepID=Q3JEI1_NITOC Length = 165 Score = 149 bits (376), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS I A+ + +IG +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI Sbjct: 2 IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ P T V +V+ + A G+ E+ VIGG +YEQ LP+A+++YLT + Sbjct: 62 VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GDT FP ++P W V+ E +D D QN + Y F LER Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160 >UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP Length = 164 Score = 148 bits (374), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+ Sbjct: 3 ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62 Query: 62 LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ Q + V +V S+ +AI + EIM+IGG +Y Q L A KLY+THI+ + Sbjct: 63 LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122 Query: 121 GDTHFPDYEPDDW--ESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP Y+ W +NS F+IL++ Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162 >UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU Length = 168 Score = 146 bits (368), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 70/160 (43%), Positives = 103/160 (64%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A+ +R+IG +N +PW+LP DLA+FK+ T +IMGR T+ESIGRPLP RKNI Sbjct: 1 MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60 Query: 61 ILSSQPGTDDR-VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++S P ++ + T V S+ + + C E VIGG ++Y P A +LY+T I E Sbjct: 61 VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD HFP+++ +W+ V SE D +N + Y F + E++ Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160 >UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS Length = 165 Score = 145 bits (367), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII Sbjct: 3 ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS D S+++A+ + EIM++GGG +++Q +P A KLYLT I A Sbjct: 63 LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +EGDT F +++ W+ + ++ + D QNS+ F IL++ Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161 >UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY Length = 176 Score = 144 bits (363), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 80/165 (48%), Positives = 104/165 (63%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAALA +RVIG +N +PW+LPADL FK TL KP+IMGR TW+S+GRPLPGR NI+ Sbjct: 11 LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70 Query: 62 LSSQPG-TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S Q G T + +++EAI A D E+M+IGG ++YE L +A +LYLT Sbjct: 71 VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + E EGD FP + W S H A A+ Y FE+ ERR Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174 >UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698640 Length = 158 Score = 144 bits (362), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 71/147 (48%), Positives = 97/147 (65%), Gaps = 1/147 (0%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 +A +RVIG N MPW+LPADL FK T+ KP++MGR TWES+ LP R +I+++ P Sbjct: 1 MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60 Query: 68 T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 + T V S+DEAIAA G+V EIMV+GGG Y + LP+ ++YLT +DAE EGDT FP Sbjct: 61 YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCF 153 D + +W E H AD ++++ Y Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPYSL 147 >UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacteria RepID=Q0VM07_ALCBS Length = 171 Score = 143 bits (361), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 70/165 (42%), Positives = 101/165 (61%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A A + VIG N +PW LP DL +FK+ T KPVIMGR TWES+ PLPGR NI+ Sbjct: 7 LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ QP + V +VD+AI +V E +++GG +Y L + Q+LYLT Sbjct: 67 ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AEV+GDT FP+Y+ +WE + E A+ N + Y F + ER+ Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171 >UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacteria RepID=A1U3D7_MARAV Length = 171 Score = 143 bits (361), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 72/166 (43%), Positives = 103/166 (62%), Gaps = 12/166 (7%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 +LI A+A +RVIG N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++ Sbjct: 4 ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63 Query: 63 SSQP------GTDDRVT----WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 S P GT + VK+ +A GD E+M+IGGG++Y + LP ++Y+ Sbjct: 64 SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGD--EVMIIGGGQIYAEALPMVDRIYI 121 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 T + AEV+GD FP+ D+WE + E A N + Y F + +R Sbjct: 122 TQVHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167 >UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZ23_9SPHI Length = 164 Score = 142 bits (357), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 71/159 (44%), Positives = 98/159 (61%), Gaps = 1/159 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+LI A A + VIG +N MPW+LP D +FK+NTL VIMGR T+E+IG+ LP R+NI+ Sbjct: 6 ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65 Query: 62 LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S +Q V S+ EAI C D E+ VIGG +YEQ LP A K+ LT + +E Sbjct: 66 ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP P++W E H AD +++ Y F++ R+ Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164 >UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD Length = 178 Score = 142 bits (357), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 71/163 (43%), Positives = 98/163 (60%), Gaps = 11/163 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A + +RVIG +N +PW LP DLA FKR TL P+IMGR TWES+GRPLPGR N++ Sbjct: 21 LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80 Query: 62 LS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +S + PG T V ++ A+ ACGD P+ VIGG ++Y Q LP A ++ T + Sbjct: 81 ISRNLRYAAPG----ATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVH 136 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 A VEGD FP W + A+N + Y F + ER+ Sbjct: 137 AHVEGDAFFPYLPSFAWRE--ASRQPQPAENGYDYDFVVYERQ 177 >UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii RepID=A9KH09_COXBN Length = 161 Score = 140 bits (354), Expect = 9e-33, Method: Compositional matrix adjust. Identities = 69/160 (43%), Positives = 107/160 (66%), Gaps = 3/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +I+LIAA+ +R+IG N +PW+LPADLA FK TL KP++MGR T++SIG+PLP R+NI Sbjct: 2 IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ Q + S+D+A++A PE+++IGG R++++ LPKA K+ LT I+ Sbjct: 62 VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD +FP++ +W+ H+ D +N Y F+ LE R Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKN--PYPFQFLELR 159 >UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU Length = 191 Score = 138 bits (347), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 70/164 (42%), Positives = 101/164 (61%), Gaps = 13/164 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLI A+A + IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+ Sbjct: 27 IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86 Query: 61 ILSSQ------PGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLY 111 ++S PG + AIAA +V EIM++GG ++Y LP +LY Sbjct: 87 VISRSLEKEALPG----CLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLY 142 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155 LTH+ A +EGDT P ++ +F E H D +N + Y FEI Sbjct: 143 LTHVHANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEI 186 >UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001787F40 Length = 162 Score = 137 bits (345), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MIS+I A+ D+VIG+ MPW LP D+A+FK TL+K ++MGR TW+S G +PLP RKN Sbjct: 1 MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60 Query: 60 IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ T+D+ + ++ A+ + E+MVIGG ++YE LPKA +LY T ID Sbjct: 61 IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGDT+FP+ D+W+ V D +N ++Y F ER+ Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162 >UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC Length = 163 Score = 137 bits (345), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 62/158 (39%), Positives = 102/158 (64%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ +++IG NA+PW LPADLA+FK+ T+ K V+MGR T++SIGRPL R+NII Sbjct: 3 LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNII 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S++ A+ E+M++GG YEQ + K ++Y+T ++ + + Sbjct: 63 VSRNTKLKVDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFD 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP+++ + + E H D +N H++ F IL++ Sbjct: 123 GDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK 160 >UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CYL9_PAESJ Length = 163 Score = 137 bits (344), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I++IAA+ R IG+ N +PW LPA++A+F R+T K V+MGR T+ES+ +PL R N++ Sbjct: 3 ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ QP + V SV EAI G+ E+MVIGG +Y QFLP A K+ LT +D +E Sbjct: 63 ITRQPEYAKEGCEVVHSVQEAIDRYGE-GELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121 Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP + +WE V +E ++D +N+ S+ F+ RR Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161 >UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI Length = 163 Score = 136 bits (343), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 71/160 (44%), Positives = 104/160 (65%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+ Sbjct: 3 ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ + VT V ++D+AIA + EI VIGG +Y+ LP A LYLT I + Sbjct: 63 LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD +FP+++ ++W+ V H AD +++ S+ F E+ Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162 >UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF Length = 170 Score = 134 bits (338), Expect = 8e-31, Method: Compositional matrix adjust. Identities = 70/164 (42%), Positives = 106/164 (64%), Gaps = 8/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAAL +RVIG++N+MPW+LP D +FK TL KP+IMGR TW+S+GRPLPGR NI+ Sbjct: 7 LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S Q G + S++ A+ + V E+M+IGG ++Y Q L +A +LYLT Sbjct: 67 VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGD FP+++ + W+ V + + A+ + +Y FE+ E+ Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPAEG-DKPAYNFEVWEK 169 >UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588 RepID=C7PKU6_CHIPD Length = 164 Score = 133 bits (334), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 62/160 (38%), Positives = 104/160 (65%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A + + VIG+ N +PW+LP D+ +FK T+ KP++MGR ++E +GR LPGR NI+ Sbjct: 3 LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIM 62 Query: 62 LSSQPG-TDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q T + + V S++ I A EI V GGG +++ L ++YLT + A Sbjct: 63 ITRQKDYTAEGLHIVPSLEAGIEKAKTFGTEEIFVTGGGEIFKMALSIVDRVYLTRVHAT 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V+GDT+FP+++P W+ V +E H+ D +++H+ F++ ER Sbjct: 123 VQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER 162 >UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME Length = 166 Score = 133 bits (334), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 68/163 (41%), Positives = 95/163 (58%), Gaps = 10/163 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +++LI A A + VIG N +PW LP DL FKR T+ P+IMGR TW+SIGRPLPGR+NI Sbjct: 3 LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62 Query: 61 ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +++ G D V S+++A C ++ +IGG ++Y + LP A +L +T I Sbjct: 63 VVTRNRDLHIEGAD----VVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEI 118 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 DA+VEGD FP + W E H ++ N Y F ER Sbjct: 119 DADVEGDAFFPAVDRTTWVETARELHHSET-NGFDYAFVTYER 160 >UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii HA RepID=A5CVJ7_VESOH Length = 163 Score = 132 bits (332), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 60/158 (37%), Positives = 100/158 (63%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ + +IG +N++PW LPADLA+FK+ T+ K ++MGR T +SIGR LP R+NII Sbjct: 3 LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNII 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S+D A++ + E+M++GG Y+Q + K +LY+T + + Sbjct: 63 VSKNTKFKADNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFD 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD +FP+++ + + E H D +N ++Y F +L+R Sbjct: 123 GDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR 160 >UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD Length = 162 Score = 131 bits (330), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 72/161 (44%), Positives = 98/161 (60%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAA+ +R+IG +N +PW+LP DL +FK T VIMGR T+ESIGRPLP R+NI Sbjct: 1 MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 I++S D + S +EA+ A E VIGG +Y + LP A KLY+T ID Sbjct: 61 IVTSNKELDIPNCQVMHSAEEAVRFAKNRNEECFVIGGSTLYTEILPFADKLYVTKIDET 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD +FP++ +WE V D +N + Y F + +R+ Sbjct: 121 FEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK 161 >UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadaceae RepID=B2I6E9_XYLF2 Length = 188 Score = 130 bits (327), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 72/159 (45%), Positives = 98/159 (61%), Gaps = 8/159 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 ++SLIAAL R IG +N +PW+LP DL FK TL +PV+MGR T S+GRPLPGR N+ Sbjct: 24 IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNL 83 Query: 61 ILSSQ---PGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +L+ P ++ R V S+D AI AA + VIGGG +Y LP A +YLTH+ Sbjct: 84 VLTRSGHVPFSEMRA--VDSLDAAIVQAAAEGADTLSVIGGGELYALTLPHANAMYLTHV 141 Query: 116 DAEVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153 D V G DT+FP ++ DWE E H D ++++ + F Sbjct: 142 DVAVAGADTYFPMFDAVDWEIKNREPHQGDGRHAYPFTF 180 >UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA Length = 219 Score = 130 bits (327), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 67/161 (41%), Positives = 95/161 (59%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A A + VIG +N +PW LP DLA+FKR T+ P++MGR T ESIGRPLPGR+NI+ Sbjct: 56 LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 115 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D S+ +A+A E +IGG ++Y + L A KL +T ID + Sbjct: 116 VTRDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 175 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP +P WE+V + H A N +Y F + R+ Sbjct: 176 FEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK 216 >UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacteria RepID=Q2Y7L3_NITMU Length = 183 Score = 130 bits (326), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 70/169 (41%), Positives = 102/169 (60%), Gaps = 14/169 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A+A +R IG +NA+PW+LP DL FK T+ P+IMGR T+ESIGR LPGR +II Sbjct: 5 LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSII 64 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDV-----------PEIMVIGGGRVYEQFLPKAQK 109 ++ QP + V S+ EA++AC + E VIGG +++Q LP + Sbjct: 65 ITRQPDYEVPGALVVSSIGEALSACKQIRSGEEGHPDQGNECFVIGGADIFQQMLPLCDR 124 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LY+T I + EGDT+FP+++ +DW V E H D+ Y F L+R Sbjct: 125 LYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR 171 >UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA Length = 175 Score = 129 bits (325), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 9/162 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+ Sbjct: 17 VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76 Query: 62 LSSQPG-TDDRVTWVKSVD----EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++ Q G + S+D A + E+MVIGG ++ + LP A++LYLT I Sbjct: 77 VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT FP +E W V ++ D ++ F IL+R Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGDP----AFDFVILDR 174 >UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1 Length = 169 Score = 129 bits (324), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 66/165 (40%), Positives = 99/165 (60%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +S + A+A + VIG +N++PW L D+A+FKR T+ KPVIMGR TWES+ R PLPGR NI Sbjct: 3 VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRKPLPGRPNI 62 Query: 61 ILSSQP-----GTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +++ G + + V+++ +A+ E+MVIGG ++Y + A +LY+T Sbjct: 63 VVTRDAQYEAEGAEIAASAVEALRRGRELASASGADEVMVIGGAQLYAEMFDDATRLYIT 122 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A EGD FP ++ W V E H A ++S Y F +LER Sbjct: 123 EVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER 167 >UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2 Length = 171 Score = 128 bits (322), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 66/169 (39%), Positives = 101/169 (59%), Gaps = 11/169 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + ++ A A + VIG+ N +PW + ADL FK+ T+ P+IMGR T++SIG+PLPGR I+ Sbjct: 3 LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIV 62 Query: 62 LSSQP-----GTDDRVTWVKSVD------EAIAACGDVPEIMVIGGGRVYEQFLPKAQKL 110 ++ Q G +D+V S++ E IAA V E M++GG ++Y Q L + K+ Sbjct: 63 VTRQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKV 122 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +LT + AE+EGD FP+ + + W V + AD +N + Y F L RR Sbjct: 123 HLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR 171 >UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobacteria RepID=A6UB22_SINMW Length = 187 Score = 128 bits (322), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 69/165 (41%), Positives = 96/165 (58%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I ++ A+A++ VIG E +PW LP DL FK T+ KPVIMGR TW +IGRPLPGR NI+ Sbjct: 14 IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIV 73 Query: 62 LSSQ-----PGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ PG + + +V AA EI VIGGG +Y Q + A L++T Sbjct: 74 VTRNRAFEAPGAEVAPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTE 133 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AEV+GDT FP+ +P +E V E + ++SH+ F RR Sbjct: 134 VQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR 178 >UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D66 Length = 161 Score = 128 bits (321), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 59/139 (42%), Positives = 90/139 (64%), Gaps = 1/139 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A++ + VIG+ N +PW++P DL FK T+ P++MGR T++SIGRPLPGRKNI+ Sbjct: 4 ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIV 63 Query: 62 LS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ ++ + V V S++ +A D + VIGG ++Y+ FL A LY+T +D++V Sbjct: 64 ITRNEDSIIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVA 123 Query: 121 GDTHFPDYEPDDWESVFSE 139 GD HFP W+ V E Sbjct: 124 GDAHFPKLSTSQWKEVGRE 142 >UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR Length = 163 Score = 127 bits (320), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 69/160 (43%), Positives = 99/160 (61%), Gaps = 6/160 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+A +RVIG NA+PW++PAD F+ TL PVIMGR T+ES+ PLPGRKNI Sbjct: 2 VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNI 61 Query: 61 ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ Q ++ + A+A G+ EI + GGG +Y Q LP A ++YLT I + Sbjct: 62 IITRQMDYRAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT FP+ P+ + V E +N+ Y F + ++R Sbjct: 122 DGDTRFPEI-PERFVEVGRE----TVENAIPYSFVLYDKR 156 >UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobiales RepID=Q2K6G9_RHIEC Length = 172 Score = 127 bits (320), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 65/164 (39%), Positives = 101/164 (61%), Gaps = 7/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 ++IAA+A + IG E MPW L +DL FK TL KPV+MGR T++SIG+PLPGR N+++ Sbjct: 7 TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVI 66 Query: 63 SSQPGTDDR-VTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLPKAQKLYLTHI 115 S Q D ++ S+ EA+ A + EI +IGGG++Y Q + A ++Y+TH+ Sbjct: 67 SRQAAIDHSDISMAHSLAEALEAAERLALQTGAGEICIIGGGQIYAQAIDLADRMYITHV 126 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +A+++GD FP +P W++ A ++S+ F + ERR Sbjct: 127 EADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR 170 >UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3 RepID=B8KL97_9GAMM Length = 182 Score = 126 bits (317), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 67/159 (42%), Positives = 98/159 (61%), Gaps = 8/159 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+LI A A + VIG +NA+PW LP DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+ Sbjct: 6 IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIV 65 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLPKAQKLYLTH 114 +S PG + V V+S+++A+ D+ E+M+IGG ++Y LP A ++YLT Sbjct: 66 ISRDPGYSAAGVRSVQSLEKALELAKDIAVIDGSSELMIIGGAQIYALALPLASRIYLTR 125 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ-NSHSYC 152 + E GD P + W+ + + AD +H++ Sbjct: 126 VHVEPAGDAFLPAIDWAHWKESGRQENPADGSVPAHTFL 164 >UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W102_DYAFD Length = 167 Score = 126 bits (317), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 62/156 (39%), Positives = 100/156 (64%), Gaps = 4/156 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+IAA++ + VIG+ N++PW+LP + A F++ T K IMGR ++E+ +N+I Sbjct: 7 LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVI 66 Query: 62 LSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S+P + RV + + + AIA D ++ V+GG V+EQ LP A ++YLT + A+V Sbjct: 67 ITSRPPAQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQV 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155 EGD FP ++ DDW+ SEFH AD + H+Y F + Sbjct: 127 EGDAFFPAFDSDDWQLADSEFHGAD--DDHAYAFSM 160 >UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteobacteria RepID=B3PTQ3_RHIE6 Length = 172 Score = 126 bits (317), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 64/164 (39%), Positives = 103/164 (62%), Gaps = 7/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 ++IAA+A + +IG + MPW L +DL FK TL KPV+MGR T++SIG+PLPGR N+++ Sbjct: 7 TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVI 66 Query: 63 SSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 S Q D V S+ EA+ A V EI ++GGG++Y Q + A ++ +TH+ Sbjct: 67 SRQAAIDHPDVAMAHSLAEAMDAAERLARETGVDEICIVGGGQIYAQAINLADRMCITHV 126 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +A+++GD FPD +PD W++ + A ++S+ + + +RR Sbjct: 127 EADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR 170 >UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA Length = 163 Score = 126 bits (316), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 64/158 (40%), Positives = 89/158 (56%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+ +G+ N + LPADL FK T+ KP+IMGR T+ESIG+PLPGR NI Sbjct: 3 LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++S + V V S+ +AI D E+M+IGG ++Y Q + A +LY+T I + Sbjct: 63 VISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFM 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 D FP W E+ D +N + F I ER Sbjct: 123 ADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER 160 >UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1CZU3_MYXXD Length = 159 Score = 125 bits (315), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 71/158 (44%), Positives = 96/158 (60%), Gaps = 14/158 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S I A+A +RVIG N +PW LPADLA FKR T+ ++MGR T+ESIGRPLPGR I+ Sbjct: 3 LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIV 62 Query: 62 LSSQ-----PGTDDRVTWVKSVDEAIA---ACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 ++ Q PG V SVDEA++ A GD E+ + GG +Y Q + + Q++YLT Sbjct: 63 VTRQRDFAPPG----VQVAHSVDEALSLAKASGD-SEVFIAGGADLYAQTMDRVQRIYLT 117 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151 HI GDT FPD + W V + H DA+ H++ Sbjct: 118 HIARNFPGDTWFPDVDLSGWTCVEEQAH-PDAEPPHTF 154 >UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD Length = 195 Score = 125 bits (315), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 63/142 (44%), Positives = 94/142 (66%), Gaps = 9/142 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+L+AA++ +RVIG++N +PW+LP DL +FK T++KP++MGR T+ESIGRPLPGR NI+ Sbjct: 19 IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIV 78 Query: 62 LSSQPG---TDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 ++ G D + + A+ A V +I VIGGG ++ + LP A +LYL Sbjct: 79 VTRDRGYAQDHDGIRVCHDLASALDMADGQAIIDGVEDICVIGGGEIFAEALPCATRLYL 138 Query: 113 THIDAEVEGDTHFPDYEPDDWE 134 T +D EVEGD FP ++ +W+ Sbjct: 139 TEVDIEVEGDAWFPAFDAREWQ 160 >UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris F0302 RepID=D1QNC5_9BACT Length = 160 Score = 124 bits (312), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 67/161 (41%), Positives = 96/161 (59%), Gaps = 4/161 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 ++SLIAA+A +R IG +N + +++ DL FKR T+ VIMGRHT+ES+ LP RKN Sbjct: 2 ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPNGALPHRKN 61 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++S + T V S EA+ C E+ VIGG +VY++ + +A +LYLT IDA Sbjct: 62 IVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALA 121 Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E D +FPDY + W V E H N ++ F + +RR Sbjct: 122 EQADAYFPDY--NSWHLVAHEAHKKSEDNPFAFAFTVYQRR 160 >UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67JQ2_SYMTH Length = 165 Score = 124 bits (311), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 67/153 (43%), Positives = 89/153 (58%), Gaps = 4/153 (2%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 + +R IG E +PW LPA++ F+R T+ K V+MGR T+ESIG PL GR NI+L+ PG Sbjct: 1 MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG 60 Query: 68 TDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 V+ SV E + D + VIGG VY QFLP A ++ LT ID + EGD FP Sbjct: 61 FRAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFP 117 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D+WE V S H D +N + + E RR Sbjct: 118 AWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR 150 >UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved in trimethoprim resistance n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YTZ2_9FLAO Length = 165 Score = 124 bits (311), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 61/160 (38%), Positives = 93/160 (58%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M +++ A+ IG EN + W+LP DL FK T PVIMGR T+ESIG+ LP R NI Sbjct: 1 MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNI 60 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++S + ++ + V S+ EA+ + E+ VIGGG +YEQ + +L +T + A+ Sbjct: 61 VVSRKKDWFEEGILIVGSIKEALKFAKKIDEEVFVIGGGNIYEQTMDVVDRLEVTLVKAD 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +E DT FP +P W+ H+ D +N + +CF+ ER Sbjct: 121 LEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER 160 >UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XKH5_9CAUL Length = 175 Score = 124 bits (310), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 68/169 (40%), Positives = 99/169 (58%), Gaps = 12/169 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I+L+ A A + VIG + +PW L +DL FK+ TL KP IMGR TWES+ RPLPGR N+ Sbjct: 6 IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPLRPLPGRLNL 65 Query: 61 ILSSQPGTDDR---------VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQK 109 +LS ++R ++D A D + EI VIGG ++E LP+A++ Sbjct: 66 VLSRDLSYEERGKAKGAVVCSNLADAIDMARETAEDDGIDEICVIGGTALFEAALPRAKR 125 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LY+T ++AE EGD FP ++ + +E HDA ++ H + F IL+R Sbjct: 126 LYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR 174 >UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XTJ0_POLNS Length = 162 Score = 124 bits (310), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 65/139 (46%), Positives = 90/139 (64%), Gaps = 6/139 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A + + VIG +N MPW + ADL +FKR T+ PVIMGR TWESIGR LPGR+NI+ Sbjct: 6 ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIV 65 Query: 62 LS---SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S S P + + V S+DEA+ + + P + VIGG +++ Q KA +LY+T ID + Sbjct: 66 VSRNASYPISGGEL--VGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLD 123 Query: 119 VE-GDTHFPDYEPDDWESV 136 +E GDT F W+ V Sbjct: 124 IEGGDTFFEVPNASAWKEV 142 >UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EUV9_DICNV Length = 164 Score = 123 bits (309), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 66/160 (41%), Positives = 95/160 (59%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LIAA ++RVIG + MPW+LP DL FK+ T +IMGR T++S+ +PLP RKNI+ Sbjct: 6 IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIV 65 Query: 62 L--SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 + S QP D V ++ EA+A C + ++ +IGGG +Y + +A L +T I E+ Sbjct: 66 ISHSGQPLHAD-VAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTEL 124 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP P DW+ ADA+N+ + F +RR Sbjct: 125 LGDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR 164 >UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MUX5_9BACT Length = 160 Score = 123 bits (309), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 62/159 (38%), Positives = 97/159 (61%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++I A+A + VIG +N + W++ DL FK T PV+MGR T+ES+GRPLPGR+N+ Sbjct: 1 MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNV 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +++ Q + + V S+DEA+A ++ VIGG ++Y Q LP + YLT + + Sbjct: 61 VVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQ 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP ++ +WE + SE + + + + FE RR Sbjct: 121 GDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR 159 >UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=B6INW3_RHOCS Length = 190 Score = 123 bits (308), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 69/166 (41%), Positives = 97/166 (58%), Gaps = 8/166 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + L+AA+A + VIG N +PW LP DL +FKR T+ KPV+MGR TWESIG +PLPGR NI Sbjct: 24 LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGAKPLPGRCNI 83 Query: 61 ILSSQPGTDDRVT-----WVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+ G ++ ++ EA +AA PE+ VIGG ++ + L A +LYLT Sbjct: 84 VLTRDTGFAPEGAIVCHGFLGAIAEARSVAARTGAPEVCVIGGESLFAEALRMADRLYLT 143 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AE GD FP ++ W E DA +S +Y L+R+ Sbjct: 144 EVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK 189 >UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae RepID=Q134B2_RHOPS Length = 179 Score = 122 bits (306), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 68/164 (41%), Positives = 93/164 (56%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I +I A+A + VIG NA+PW L +D FK+ TLNKPVIMGR T++SIGRPLPGR NI+ Sbjct: 12 IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIV 71 Query: 62 LSSQPGTDDRVTWVKSVDEAI--AACGD-----VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ V EA A GD E++V+GG +Y +LP+A + LT Sbjct: 72 VTRDTHFQAAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTE 131 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GDT FP +PD WE V H A ++S + + R Sbjct: 132 VHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR 175 >UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO Length = 162 Score = 122 bits (305), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 61/134 (45%), Positives = 85/134 (63%), Gaps = 2/134 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I++IAA A + IG NAMPW++P D A+FK TL KPVIMGR TWES+ +PLPGR+NI Sbjct: 4 ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNI 63 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S Q V S++ A+A C E +++GG ++Y Q +P A L +T +D V Sbjct: 64 VISRQADYCAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123 Query: 120 EGDTHFPDYEPDDW 133 EGD FP+ + W Sbjct: 124 EGDAFFPEIDRTHW 137 >UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3 Length = 167 Score = 121 bits (303), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 61/161 (37%), Positives = 93/161 (57%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI+++ A+ + IG +N + W+LP DL FK T P+IMGR T+ESIGRPLP R NI Sbjct: 1 MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNI 60 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++S + + V V S+ EA+ + E + VIGGG +YEQ + A KL +T + AE Sbjct: 61 VVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAE 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D FP + WE D D ++++ +CF+ ++ Sbjct: 121 INADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK 161 >UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2 Length = 161 Score = 120 bits (302), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 62/164 (37%), Positives = 94/164 (57%), Gaps = 9/164 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A+ +R+IG +N +PW+LP DLA+FK+ T ++MGR T+ESIGRPLP R+NI Sbjct: 1 MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNI 60 Query: 61 ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +++S+ PG S +E + E VIGG ++Y P A +LY+T I Sbjct: 61 VVTSRDESSFPG----CITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKI 116 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP++ +WE + D +N + Y + + E++ Sbjct: 117 HHVFEGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK 160 >UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA Length = 166 Score = 120 bits (302), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 62/158 (39%), Positives = 89/158 (56%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A+ RVIG +N +PW + +D + K T +I+GR +SIGR LP R+NII Sbjct: 7 ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNII 66 Query: 62 LSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ + + + S++ A C + E+ + GG ++Y FLP +K+Y+T I E E Sbjct: 67 LTRDKNFNFKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFE 126 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP DDW+ V E D +N + Y F I ER Sbjct: 127 GDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER 164 >UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia floridanus RepID=Q7VQK5_BLOFL Length = 168 Score = 120 bits (302), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 64/171 (37%), Positives = 95/171 (55%), Gaps = 18/171 (10%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 +ISLIAA ++ VIG +N +PW D+ WFK +T+ KPVIMGR T+ES+ +PLP R N Sbjct: 2 IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRLN 61 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVP---------EIMVIGGGRVYEQFLPKAQKL 110 I+LS + + + AC + E+M+IGGG VY F+ + ++ Sbjct: 62 IVLSKH-----HILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRM 116 Query: 111 YLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSY--CFEILER 158 YLT ID GD+ FP Y P++W V++ ++Y F+IL+R Sbjct: 117 YLTKIDVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDR 167 >UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XMY9_HIRBI Length = 182 Score = 120 bits (301), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 66/166 (39%), Positives = 93/166 (56%), Gaps = 8/166 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +++I A A + VIG++ +PW L DL +FK TL KPVIMGR TWES+ +PL GR N+ Sbjct: 15 LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPFKPLKGRANL 74 Query: 61 ILSSQPGTDDRVTWV-------KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 ++S + D + V + AIA DV E+M+IGGG +Y LY+T Sbjct: 75 VVSRRHDFDAQGARVFPSLGVAIAAGRAIADQTDVEEVMIIGGGAIYTAAFENVDVLYVT 134 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ E EGDT FP+ + D W V H AD N H++ L R+ Sbjct: 135 EVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK 180 >UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP Length = 259 Score = 120 bits (301), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 72/167 (43%), Positives = 96/167 (57%), Gaps = 13/167 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 +++IAA A + VIG N +PW LP DLA F+ T PVIMGR TWES+ RPLPGR+ Sbjct: 3 LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLPARFRPLPGRR 62 Query: 59 NIILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 NII+S G V V S++ A+ VIGG R+YE LP A +L+LT ID Sbjct: 63 NIIVSRGGVRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEID 122 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFH----DADAQNSHSYCFEILERR 159 + EGD +FP+++ S F E H A+A N+ +Y F R+ Sbjct: 123 EDFEGDVYFPEFD----RSAFVEHHRMRRQAEAPNTFTYSFAHYRRK 165 >UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perfringens SM101 RepID=Q0SWS9_CLOPS Length = 161 Score = 119 bits (299), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 59/161 (36%), Positives = 96/161 (59%), Gaps = 5/161 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M S+I A +++ +IG+ N +PWN+P+DL FK T+ K ++MGR T+ES+ LPGR ++ Sbjct: 1 MFSIIVAKSINNIIGVNNKIPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60 Query: 61 ILSSQPG---TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+++ V +D+ I+ D + EI VIGGG++Y +FL A KLY+T + Sbjct: 61 VLTTKKDFSYNHKDVIIYNDLDKLISEYKDSMEEIFVIGGGKIYSEFLKYASKLYITEVL 120 Query: 117 AEVEGDTHFPDYEPDDWESVF-SEFHDADAQNSHSYCFEIL 156 E +GDT+FP + W + S ++ +A +EIL Sbjct: 121 KEYKGDTYFPKVDYSKWIKTYESSIYEENATKFKYVIYEIL 161 >UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110 RepID=C5CTW3_VARPS Length = 177 Score = 119 bits (298), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 64/163 (39%), Positives = 93/163 (57%), Gaps = 7/163 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LI A A + VIG + +PW+LP D+ FK+ T PV+MGR TW+S+ RPLPGR+ Sbjct: 10 IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69 Query: 59 NIILSSQPGTDDRVTW-VKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 NI+++ Q W V S+ EA+A C VP++ +IGG ++Y + P AQ++ +T + Sbjct: 70 NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQVVVTEL 129 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGD H P+ P W E H A+ +Y F ER Sbjct: 130 AHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER 171 >UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XJM4_9BACT Length = 156 Score = 118 bits (296), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 58/125 (46%), Positives = 78/125 (62%), Gaps = 1/125 (0%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 IAA++ +RVIG N +PW+LP D WFK+ T + V+MGR T+ESIGRPLP R+ I+LS Sbjct: 7 IAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIVLSR 66 Query: 65 QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTH 124 P V + + E I+ + EI + GG ++YEQ LP LYLT + VEGD Sbjct: 67 GPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEGDAF 125 Query: 125 FPDYE 129 FP +E Sbjct: 126 FPTFE 130 >UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organisms RepID=Q5P234_AZOSE Length = 167 Score = 118 bits (295), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 68/165 (41%), Positives = 94/165 (56%), Gaps = 12/165 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 + +IAA A + IG +N +PW L +DLA FK T+ PV+MGR TWES+GRPLP R+N+ Sbjct: 7 QVIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNL 66 Query: 61 ILSSQPGTDDRVTWVKSV------DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ T DR + A+ A GD + VIGG +Y Q L A L LT Sbjct: 67 VV-----TRDRSYSATGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTE 120 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + A+V GD +FP ++ D++ V E HDADA N S+ F R+ Sbjct: 121 VHADVAGDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK 165 >UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6 Length = 160 Score = 118 bits (295), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 61/158 (38%), Positives = 91/158 (57%), Gaps = 3/158 (1%) Query: 4 LIAALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +I A DR IG +N MPW+LP DL +FK+ T K ++MGR T+ES+G+ LP RK I+ Sbjct: 2 IIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTIV 61 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ D + S +E +A I V+GG +Y F+ A KL +T IDAE + Sbjct: 62 LTRDKELQLDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEFD 121 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 DT FP+ + +++ + E H+ D +N ++Y F ER Sbjct: 122 ADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER 159 >UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XJD1_MEIRU Length = 171 Score = 118 bits (295), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 62/159 (38%), Positives = 94/159 (59%), Gaps = 5/159 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ + A+ +R IG +PW+LP DL F+ TL K V+MGR T+ESIGRPLP R+N++ Sbjct: 5 IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVV 64 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 L+ P + V V ++++A+ E+MVIGGG +Y FLP L+LT ++ V Sbjct: 65 LTRDPAFAAEGVEVVHTLEDALKLDD---ELMVIGGGEIYTLFLPLVTHLHLTLVETVVP 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + D FP + P W + E H AD ++ ++ + LER Sbjct: 122 DADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER 160 >UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM Length = 180 Score = 117 bits (294), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 61/162 (37%), Positives = 93/162 (57%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLI A + IG EN + W L DL FK+ T N ++MGR T+ESIGRPLP RKNI Sbjct: 15 MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNI 74 Query: 61 ILS-SQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 IL+ + D+ + S + + P EI +IGG ++Y++FL A +LY+T +DA Sbjct: 75 ILTRDKDYKQDKCLIINSTQDILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDA 134 Query: 118 EV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E+ + D FP ++ ++ + + D +N + F + E+ Sbjct: 135 EMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK 176 >UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN Length = 170 Score = 117 bits (293), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 60/163 (36%), Positives = 92/163 (56%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL--NKPVIMGRHTWESIGRPLPGRK 58 M+S++ A+ + VIG ++++PW+LP DL +FK+ TL +K +IMGR T++S+ LPGRK Sbjct: 1 MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLTESKTMIMGRKTFQSLKALLPGRK 60 Query: 59 NIILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +IIL+ D V + +D D E VIGGG ++ LP +K+Y+T I Sbjct: 61 HIILTKNKNFNMKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP+ DW + D +N +++ F IL R Sbjct: 121 HHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR 163 >UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS77_9GAMM Length = 162 Score = 117 bits (293), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 63/155 (40%), Positives = 90/155 (58%), Gaps = 5/155 (3%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 +A +RVIG + +PW LPAD+ F T KP++MGR ++IGR LPGR NI+LS P Sbjct: 1 MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPA 60 Query: 68 TDDRV---TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTH 124 RV V ++ A+A EIM+IGG ++Y FL +A ++YLT + VEGD Sbjct: 61 --HRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAF 118 Query: 125 FPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 FP + +W+ + ADA N+++ F L RR Sbjct: 119 FPHLDAAEWQESARQSRLADADNAYALTFLTLLRR 153 >UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8X9J8_NAKMY Length = 292 Score = 117 bits (292), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 10/160 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A + VIG MPW++PADL FKR T+ P++MGR T+ES+G LPGR++I+ Sbjct: 8 VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMGL-LPGRRSIV 66 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++ P S+D AIA P +MV+GGG +Y Q LP+A +L +TH+D Sbjct: 67 ITRDPHWRAPGAEVADSLDRAIALGAQTDPVVMVVGGGEIYAQALPRADRLEITHLDLSA 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP +P W D + + Y F RR Sbjct: 127 PGDTVFPAIDPALWAVT-------DREEADGYAFVTYRRR 159 >UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9ECC1_MACCJ Length = 164 Score = 116 bits (290), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 57/140 (40%), Positives = 87/140 (62%), Gaps = 1/140 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA++ + VIG + +PW +P + FK T+ K VIMGR T+ESIG+PLP RK I Sbjct: 2 IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTI 61 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + + V+S++ A EI + GGG +Y++ LP A ++YLT I+ E Sbjct: 62 IISKSKDINYNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEY 121 Query: 120 EGDTHFPDYEPDDWESVFSE 139 EG+ FP + D++E + + Sbjct: 122 EGNIFFPMFNKDEFEITYQQ 141 >UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT Length = 169 Score = 116 bits (290), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 64/169 (37%), Positives = 90/169 (53%), Gaps = 10/169 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MISLIAA+A + IG + W LP D+ +F+ T K VIMGR TWES+ RPLP R Sbjct: 1 MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPPAYRPLPNR 60 Query: 58 KNIILSSQPGTDDRVT-WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS P R S+++A+ G E+ +IGG +Y Q +P A +LY+T + Sbjct: 61 RNIVLSRNPAYLPRGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVA 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSH------SYCFEILERR 159 E GD FPD +W + + A S ++ F + ERR Sbjct: 121 EESPGDAFFPDVASGEWREISRRVGRSRAAGSALRDQAPAFDFVVYERR 169 >UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui RepID=DYR2_HALMA Length = 167 Score = 116 bits (290), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 70/150 (46%), Positives = 87/150 (58%), Gaps = 11/150 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR----PLPGR 57 +SLIAA+A + VIG +PW P DL FK T+ PVIMGR T+ESI R PLP R Sbjct: 5 LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRDLDGPLPER 64 Query: 58 KNIILSSQP-GTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 NI+L++ P D VT V S A+ AA D VIGG VYEQFLP+A +L LT Sbjct: 65 LNIVLTTTPHQLPDSVTAVTSTTAAVAEAADSDASTTYVIGGATVYEQFLPQADELILTE 124 Query: 115 IDAEVEGDTHFPDYEPDDW----ESVFSEF 140 + A +GDT FP + +W + SEF Sbjct: 125 LAAAFDGDTVFPTVDWSNWTEMERTTHSEF 154 >UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0C500_HYPNA Length = 176 Score = 115 bits (288), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 71/165 (43%), Positives = 91/165 (55%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 + LI A A +R+IG A+PW L D+A+FK T+ PVIMGR TWES RPLPGR+NI Sbjct: 7 LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGRENI 66 Query: 61 ILSSQPGTDDRVTWVKS-------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+ D V S AIAA E VIGG +Y LP A ++YLT Sbjct: 67 VLTRDWDYDAAEARVYSSFPAAMNAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLT 126 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +DAE+EGDT FP+ + W S H A N H++ L+R Sbjct: 127 EVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR 171 >UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA Length = 180 Score = 114 bits (286), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 I IAA +RVIG + MPW+LPAD A F+ ++ KP IMGR ++++ R PLP R NI Sbjct: 17 IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRKPLPERVNI 76 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ D S +EA+ GD PEI +IGG +Y + + +L +T I AE+ Sbjct: 77 VLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAEL 136 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT FP+ P +WE F AD +N + F+ RR Sbjct: 137 DGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR 175 >UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QWB5_9PLAN Length = 171 Score = 114 bits (285), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 59/159 (37%), Positives = 94/159 (59%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLI A+ + +IG + +PW + ADL F+ T+ +IMGR TW+S+GR LPGR +I+ Sbjct: 11 LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIV 70 Query: 62 LSSQPG--TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ + + V S+DEAIA E +IGGG +Y Q + + Q+LY+T ++A + Sbjct: 71 LTRKADLVLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANI 130 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT FP ++P + + H A+ + ++ F ER Sbjct: 131 EGDTWFPAWDPSKFRLLEETSHPAEG-TTPAFTFTRYER 168 >UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB Length = 170 Score = 114 bits (284), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 64/164 (39%), Positives = 92/164 (56%), Gaps = 5/164 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+ I A + + VIG N +PW+LP DL +F++ T NK V+MGR T+ES G + LP R N Sbjct: 1 MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGSKALPKRLN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPE----IMVIGGGRVYEQFLPKAQKLYLTHI 115 IIL+S VK V I A E + VIGG VYE F+ A +L +T + Sbjct: 61 IILTSNMDFKSNDPEVKIVHSPIEAVNTAKEQHLPLYVIGGASVYESFMNMADRLLITLV 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DA ++GDT P++ + V H D ++++S+ F ER+ Sbjct: 121 DANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK 164 >UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFCBD Length = 161 Score = 113 bits (283), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 54/128 (42%), Positives = 87/128 (67%), Gaps = 6/128 (4%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 +I A++ + IG+ N +PWN+ D+ +F++ T K VIMGR T+ SIGRPLP R+NI+L+ Sbjct: 1 MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLT 60 Query: 64 SQPGTDDRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 + TD ++ V+ V EA+ + + VIGGG++YE F+P A++LY+T +D +++ Sbjct: 61 TN--TDLKIAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDID 117 Query: 121 GDTHFPDY 128 GD FP+Y Sbjct: 118 GDAAFPEY 125 >UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD Length = 195 Score = 113 bits (282), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 64/145 (44%), Positives = 83/145 (57%), Gaps = 11/145 (7%) Query: 6 AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNII 61 AA+A + +IG + MPW++PADL FKR T+ PVI+GR T+E+I G P PGR +I+ Sbjct: 37 AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIIGALGEPFPGRTSIV 96 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 LSSQ V V S+ AI V + V GGG VYEQFLP A +L LT Sbjct: 97 LSSQSRDVPADVILVHSITSAIREASKNARERGVGTVYVAGGGGVYEQFLPLADRLRLTE 156 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSE 139 + E EGDT FP ++ W+ E Sbjct: 157 LHDEYEGDTKFPSWDDTVWQETTRE 181 >UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacteriaceae RepID=B9LR90_HALLT Length = 194 Score = 113 bits (282), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 66/171 (38%), Positives = 98/171 (57%), Gaps = 14/171 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWES----IGRPLPGR 57 + L+AA+A +RVIG + MPW+ PADLA FKR T PVI+GR T+ES IG PLP R Sbjct: 21 LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESIADRIGGPLPDR 80 Query: 58 KNIILSSQP-GTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKL 110 +++L+++ + +DEA+ G V ++ VIGG VYEQFL +A ++ Sbjct: 81 TSVVLTTRDLDLPEGAVVANDLDEAVDLAGADAADRGVDDVYVIGGATVYEQFLDRADRM 140 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ---NSHSYCFEILER 158 LT + + +GDT FPD++ ++W E AD + + + F ER Sbjct: 141 VLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGGEADALAFVTYER 191 >UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W5S3_DYAFD Length = 183 Score = 112 bits (281), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 63/158 (39%), Positives = 90/158 (56%), Gaps = 5/158 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A A + IG +N + W L DL FK+ TL P+IMGR T+ESIG+PLPGR +I+ Sbjct: 20 ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIV 79 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D V V S+DEA+ ++ E+ ++GGG +YEQ A +YLT + Sbjct: 80 ITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVHTS 139 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 V GDT F EP+ W H+ D + H + FE + Sbjct: 140 VVGDTFFSIREPEAWTETERISHEPDER--HIFPFEFI 175 >UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P459_9PROT Length = 177 Score = 112 bits (281), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 54/153 (35%), Positives = 82/153 (53%), Gaps = 1/153 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLI A+A +R IG+ N +PW P DL FK T+ +IMGR T++SIG+PLPGR ++ Sbjct: 19 LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVV 78 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + + S+ EA+ C EI V+GG +Y Q + LY+T I +V Sbjct: 79 ITRNNDLEIEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVA 138 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153 GD HFP+ + W+ E + + F Sbjct: 139 GDAHFPEIDKAFWQETSREMRSQETPQPMDFHF 171 >UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2UP70_AKKM8 Length = 159 Score = 112 bits (281), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 61/142 (42%), Positives = 82/142 (57%), Gaps = 2/142 (1%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A+A DR IG A+PW+LP DL FKR T PV+MGR T+ESIGRPLPGR+NI+L+ Sbjct: 10 VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTR 69 Query: 65 QPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123 P T + V V S E PEIMVIGG ++ +P +++++ + E DT Sbjct: 70 DPAWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADT 129 Query: 124 HFPDYEPDDWESVFSE-FHDAD 144 P +E +V E F D D Sbjct: 130 FLPPFENRLERAVLKEHFEDFD 151 >UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37DF3 Length = 160 Score = 112 bits (279), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 59/146 (40%), Positives = 88/146 (60%), Gaps = 3/146 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS+IAA A + VIG +PW++P D+A+F+R T VIMGR T+E IGRPLPGR N+ Sbjct: 1 MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNV 60 Query: 61 ILSSQPGTDDRVTWVK-SVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++S++ T T + S+ EA+ G+ I + GG VY + L A ++YLT +D Sbjct: 61 VVSAKMQTAPEGTALAHSLAEAVEIAGNSGRENIFLCGGAAVYREGLAFADRIYLTILDK 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDA 143 E GD +FP++ ++ E D+ Sbjct: 121 EYSGDVYFPEFSEKEFRLTSYERCDS 146 >UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perfringens RepID=Q0TV23_CLOP1 Length = 161 Score = 111 bits (278), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 54/159 (33%), Positives = 92/159 (57%), Gaps = 5/159 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M S+I A +++ +IG+ N MPWN+P+DL FK T+ K ++MGR T+ES+ LPGR ++ Sbjct: 1 MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60 Query: 61 ILSSQPG---TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+++ V +++ I+ D + EI VIGGG++Y + L KLY+T + Sbjct: 61 VLTTKKDFSYNHKDVIIYNDLNKLISEYKDSMEEIFVIGGGKIYSELLKYTSKLYITEVL 120 Query: 117 AEVEGDTHFPDYEPDDWESVF-SEFHDADAQNSHSYCFE 154 E +GDT+FP + W + S H+ + + ++ Sbjct: 121 KEYKGDTYFPKVDYYKWIKTYESSIHEENGNKFKFFNYK 159 >UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU Length = 156 Score = 111 bits (278), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 57/140 (40%), Positives = 88/140 (62%), Gaps = 4/140 (2%) Query: 1 MISLIAALAVDRVIGME---NAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57 MI++I A D +IG + N MPWN+P DL FK TLNK ++MG T+++IGRPLP R Sbjct: 1 MINIIVATDEDLLIGKKDSRNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNR 60 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116 K I++S +P D+RV S++E I E + + GG +Y+Q LP A +L ++ I Sbjct: 61 KTIVVSFEPFEDERVEVRSSLEEVIEEYRSSGEDLFISGGASIYKQCLPIADQLLISRIP 120 Query: 117 AEVEGDTHFPDYEPDDWESV 136 + EG+T+FP+++ ++ V Sbjct: 121 GKHEGETYFPNFDEYGYKLV 140 >UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage phiNIT1 RepID=D0VXF2_9VIRU Length = 168 Score = 111 bits (278), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 56/161 (34%), Positives = 91/161 (56%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LIAA+ ++ IG +N + W++ D+ WF++ T NK V+MGR T+ESIG+PL GR N++ Sbjct: 3 VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVV 62 Query: 62 LSSQPGTDDR--VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ D V ++++ + EIMVIGG +Y QF P A ++YLT ++ Sbjct: 63 LTHNKEYDPHPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTY 122 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E D FP+++ W F + D Y F + ++R Sbjct: 123 EEADAFFPEFDCSIWNRYF--YQDGSEDIGIKYNFSVYKKR 161 >UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FJX2_FLAJ1 Length = 160 Score = 110 bits (276), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 59/160 (36%), Positives = 91/160 (56%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI +IAA+A + +G N + W+LP D FK T N +IMGR T+ES +PLP R +I Sbjct: 1 MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ Q + + V S+++AIAAC + + +IGGG +Y LP A + +T + Sbjct: 61 IITRQTDYNPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP +W+ V SE + D ++ + Y +E R+ Sbjct: 121 EGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK 160 >UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5 Length = 164 Score = 110 bits (275), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 69/162 (42%), Positives = 96/162 (59%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A + IG +N +PW LP DL FK TL KP++MGR T +S+GR LPGR N++ Sbjct: 3 LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ D + V SV++AI A E+ VIGGG VY + +A L +T +D Sbjct: 63 LTRSGQVPFDGMQAVASVEQAIERAVQEGAQELCVIGGGEVYRLTMERADLLAVTEVDTA 122 Query: 119 VEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V+G DTHFP +P W E H ADA+++H++ F ERR Sbjct: 123 VDGADTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR 164 >UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400 RepID=Q13PE2_BURXL Length = 171 Score = 110 bits (275), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 57/128 (44%), Positives = 78/128 (60%), Gaps = 2/128 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A +RVIG+ N +PW +P + F+ T+N+ V+MGR T+ESIG+PLPGR ++ Sbjct: 7 VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLV 66 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LSS V VKS E AA + P I V GG +VY +P A +YLT ID Sbjct: 67 LSSGTSRLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDLRP 126 Query: 120 EGDTHFPD 127 GD FP+ Sbjct: 127 PGDAFFPE 134 >UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHY5_9BACT Length = 141 Score = 110 bits (274), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 57/141 (40%), Positives = 84/141 (59%), Gaps = 4/141 (2%) Query: 20 MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVK-SV 78 MPW + DL FK T+ PVIMG++TW SIG+PLPGR+NI+LS + V S+ Sbjct: 1 MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAHSL 60 Query: 79 DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFS 138 +EA+ + E +IGG V++QFLP A K+ +T I +E EGDT+FP + +DW + Sbjct: 61 EEALKMV-EGQEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDW--ILQ 117 Query: 139 EFHDADAQNSHSYCFEILERR 159 E + + + C +I R+ Sbjct: 118 ESSSLLSSSGYELCLQIYIRK 138 >UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO Length = 164 Score = 110 bits (274), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 60/156 (38%), Positives = 90/156 (57%), Gaps = 3/156 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++IAA+A + +G N + W+LPADL FK+ T ++MGR+T+ESIGRPLP R I Sbjct: 1 MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITI 60 Query: 61 ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPK--AQKLYLTHIDA 117 I++ ++ + SV++A+ D +I +IGG +VYE + A L +T + Sbjct: 61 IITKNEEYVQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMKHDFADALDITLVHH 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153 E E D +FP+ +P W V E AD +N Y F Sbjct: 121 EFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSF 156 >UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2 Length = 178 Score = 110 bits (274), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 57/144 (39%), Positives = 85/144 (59%), Gaps = 10/144 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A++ + VIG + +PW LP+DL F+ T KP++MGR T+ESIGRPLPGR +++ Sbjct: 11 LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVV 70 Query: 62 LSSQPGTDDRVTWVKS---------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 +S+ P +K DEA A G EIMVIGG R++ LP A+ L+L Sbjct: 71 VSTDPAFTVPEGVLKGASLEDGLRLADEAADAMG-ADEIMVIGGARLFHDTLPLARTLHL 129 Query: 113 THIDAEVEGDTHFPDYEPDDWESV 136 T + A +GD FP ++ W + Sbjct: 130 TQVHAAPDGDVFFPAFDEAQWREI 153 >UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11US6_CYTH3 Length = 161 Score = 109 bits (273), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 66/162 (40%), Positives = 90/162 (55%), Gaps = 10/162 (6%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 S+I A + +R IG+ N +PW+LPADL FK T+ +IMGR T+ESIG PLPGR +I++ Sbjct: 4 SIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTSIVV 63 Query: 63 SSQPGTDDRV----TWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 + D V T S+ EA IA + E VIGG + ++ + KLYLT I Sbjct: 64 TRNK---DLVFAGCTMAHSLAEAFEIAQNNNDSEAFVIGGAELIKEAINSCDKLYLTTIH 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT F D DW+ H D +N++SY F E+ Sbjct: 121 QNFEGDT-FLDALASDWKETEHVVHAPDDKNAYSYSFITYEK 161 >UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR Length = 163 Score = 109 bits (273), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 60/166 (36%), Positives = 93/166 (56%), Gaps = 14/166 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LIAA+A +RVIG +N + WNLP D+A FK T + V+MGR TWES+ RPLPGR+ Sbjct: 4 IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPPRFRPLPGRR 63 Query: 59 NIILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 N+++S Q PG + S++ A+ + +IGG ++Y+Q + A +L +T Sbjct: 64 NVVISRQADYAAPGAE----VANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEIT 119 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +D E GD FP+ DW ++ + +Q+ + F R+ Sbjct: 120 DVDLEPAGDAWFPEIAATDWS--VTQKNTPPSQSGTGFSFVTYRRK 163 >UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017452A7 Length = 167 Score = 108 bits (271), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 56/131 (42%), Positives = 77/131 (58%), Gaps = 4/131 (3%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60 IAA+A +RVIG + +PW+LP DL +FK+ T PV+MGR T+ESI G+PLP R+NI Sbjct: 14 IAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIVAALGKPLPNRRNI 73 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +LSS + V + + + +IGG ++YE LP +L LT ID E Sbjct: 74 VLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQPYE 133 Query: 121 GDTHFPDYEPD 131 GD FP +E D Sbjct: 134 GDAFFPAFEGD 144 >UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus aureus RepID=DYR_STAAC Length = 159 Score = 108 bits (271), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 56/159 (35%), Positives = 92/159 (57%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A + RVIG EN +PW+LP DL K+ + ++MGR T+ESIG+PLP R+N++ Sbjct: 3 LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+S + + V + S+++ G V + GG ++E+ + K +Y+T I+ + Sbjct: 63 LTSDTSFNVEGVDVIHSIEDIYQLPGHV---FIFGGQTLFEEMIDKVDDMYITVIEGKFR 119 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP Y +DWE S D +N+ + F L R+ Sbjct: 120 GDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 158 >UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ Length = 161 Score = 108 bits (270), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 58/159 (36%), Positives = 90/159 (56%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A RVIG +N +PW+LP DL K+ T ++MGR T+ SIG+PLP R+N++ Sbjct: 3 LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVV 62 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L++Q + V + S+DE G V + GG ++E + + +Y+T ID + + Sbjct: 63 LTNQASFHHEGVDVINSLDEIKELSGHV---FIFGGQTLFEAMIDQVDDMYITVIDGKFQ 119 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP Y ++WE S D +N+ + F L RR Sbjct: 120 GDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR 158 >UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1IBP0_9CLOT Length = 161 Score = 108 bits (270), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 2/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 MISLI A+ + IG +N + ++ DL +FKR T ++MG +T+ S+ RPLP R+N Sbjct: 1 MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPKRPLPNRRN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+L+++ + V S++E + E + GG +Y Q LP A KLY+THI E Sbjct: 61 IVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT+FP+ D+WE S H + + H + F I + Sbjct: 121 EADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK 158 >UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0AN20_MARMM Length = 173 Score = 108 bits (269), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 61/165 (36%), Positives = 93/165 (56%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 + L+ A ++ VIG++ +PW L +DL FK T KP+IMGR TWES+ RPLPGR NI Sbjct: 8 LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPRRPLPGRLNI 67 Query: 61 ILSSQPGTDDRVTWV-----KSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +++ Q G V +++D A A V E+ VIGG ++Y L +A +LYLT Sbjct: 68 VVTRQDGYVAEGGHVAGDLGEAMDAAFMRADADGVDEVCVIGGAQIYAATLERADRLYLT 127 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++A EG+T P+ + W E + A + H++ +L+R Sbjct: 128 EVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR 172 >UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HTR7_9SPHI Length = 166 Score = 107 bits (268), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 58/161 (36%), Positives = 92/161 (57%), Gaps = 4/161 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLIAA+A + VIG N + W +P D FK T ++MGR T+ES+G+PLP R +++ Sbjct: 3 ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLV 62 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +S + ++V++A C + ++ VIGGG +Y+Q + A +L +T +DA Sbjct: 63 ISRNKNYKVPEGHHLFENVEDAFIYCNKLGIEKLYVIGGGEIYKQTISIADELLITEVDA 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP+ + + W+ V E +D N H + F ER Sbjct: 123 TPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER 163 >UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SJK6_9BACT Length = 156 Score = 107 bits (267), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 52/138 (37%), Positives = 79/138 (57%), Gaps = 1/138 (0%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 +LI A+ DRVIG N MPW+LP DL FK T + MGR T+ESIGRPLP R+N ++ Sbjct: 4 ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVI 63 Query: 63 SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 + D SV E I A + + + IGGG++Y + ++++++I +G Sbjct: 64 TRSGKEYDGCRVFGSVQECIKAAEEYDKTLFFIGGGQIYSDAVDMVDEMHISYIKENYDG 123 Query: 122 DTHFPDYEPDDWESVFSE 139 DT FP+++ W+ +E Sbjct: 124 DTFFPEFDESRWKVTETE 141 >UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB Length = 306 Score = 107 bits (266), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 62/158 (39%), Positives = 91/158 (57%), Gaps = 4/158 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS IAAL+ +RVIG + +PW++P+DL F+ T+ VIMGR T+ESIG PL GR+NI Sbjct: 2 IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNI 61 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +L+ + + ++V AIAA E+ + GGG V+++ LP Q+LYLT + Sbjct: 62 VLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYR 121 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD P+ E EF D +S F +LE+ Sbjct: 122 GDAFLPELPEGFVELHREEFPDTTPPSS----FVVLEK 155 >UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI Length = 162 Score = 106 bits (265), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 58/160 (36%), Positives = 86/160 (53%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A + +IG +PW+LP D+A+FK+ T+ P+I G T+ S RPLPGR+NI Sbjct: 1 MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +LS D V + SV++ P+ V GG ++ Q L K +LY T I + Sbjct: 61 VLSRHGDFPDGVLVISSVEQLCELVDKNPKENYFVTGGANLFGQLLDKVDRLYRTKIHHQ 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+ P+ + + V S D +N + + FE+ ER Sbjct: 121 FTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER 160 >UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP Length = 173 Score = 106 bits (264), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 60/171 (35%), Positives = 92/171 (53%), Gaps = 14/171 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LI+A++ + VIG N + W+LP DL FK T + V+MGR T+ESIG+ LPGR+NII Sbjct: 3 IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNII 62 Query: 62 LS--------SQPGTDDRVTWVKSVDEAIAACGDV-----PEIMVIGGGRVYEQFLPKAQ 108 L+ S T+++ T + E ++ + +I VIGG ++Y + KA Sbjct: 63 LTKKNKIHFFSSTNTNNK-TNPRGTFEVYSSLKQIYDLNYKKIFVIGGEKIYTSTIDKAH 121 Query: 109 KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + LT I + GD FP W+ + FH+ D + ++Y F ER+ Sbjct: 122 IIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK 172 >UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105 RepID=A6GQA5_9BURK Length = 188 Score = 106 bits (264), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 62/161 (38%), Positives = 92/161 (57%), Gaps = 26/161 (16%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++AA+A + +IG+ N++PW+LP DLA+FK+ TL PV+MGR T+ESI RPLPGR N++ Sbjct: 3 VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVV 62 Query: 62 LSSQ------PGTDDR----VTWVKSVDEA----IAACGDVP----------EIMVIGGG 97 LSS PG D +T ++ E IA ++P ++ +IGG Sbjct: 63 LSSNSDWKPAPGKDGTPRSVITHPAALPEGSATQIATATNLPDALNWLSSFEQVFLIGGS 122 Query: 98 RVYEQFLPKA--QKLYLTHIDAEVEGDTHFPDYEPDDWESV 136 +YEQ L + +L LT I EGD FP ++ + V Sbjct: 123 NLYEQALAQGLVDELILTEIHQSFEGDASFPQWDRQQFREV 163 >UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB Length = 164 Score = 106 bits (264), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+S+I A+A + VIG +N + W++ DL FK T K ++MGR T+ES+ LP RK+I Sbjct: 1 MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHI 60 Query: 61 ILSSQPG---TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IL+ + V + DE + + E+ +IGGG +Y+Q LP + KLYLT I+ Sbjct: 61 ILTRDKNFKVNSECVEIIYDFDELLNKYKNSDDEVFIIGGGEIYKQLLPYSNKLYLTKIN 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GDT+FP +D++ + D ++ Y F L R Sbjct: 121 KDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR 162 >UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYS7_9BACL Length = 163 Score = 106 bits (264), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 51/160 (31%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+SLI A ++ IG EN +PW L D+ K T N+ +IMGR T +SIGR LP R N Sbjct: 1 MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINR 60 Query: 61 ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ + + ++ D++I + + + GGG +Y ++ K ++++T ++ V Sbjct: 61 VLTRDKDSLSHYSNIEVYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIV 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E DT FP+++ ++WE + E D N + F +R+ Sbjct: 121 EADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK 160 >UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus asiaticus 5a2 RepID=B3ER85_AMOA5 Length = 164 Score = 106 bits (264), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 65/160 (40%), Positives = 90/160 (56%), Gaps = 3/160 (1%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 S+I A AV+ VIG + +PW++PADL FK T VIMGR T+ES+ LP RK IIL Sbjct: 4 SIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKIIIL 63 Query: 63 SSQPGTD-DRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 S + T V S++ A IA + E+ + GG VY + L K+YLT I +V Sbjct: 64 SQSLNYKVEDCTVVPSLEMALEIANQANETEVFIAGGAAVYREALGIVDKIYLTVIHTDV 123 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGDT FP + W V H+ D +++++Y F L +R Sbjct: 124 EGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR 163 >UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGC7_LIBAP Length = 176 Score = 105 bits (263), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 54/139 (38%), Positives = 80/139 (57%), Gaps = 6/139 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LIAA+ + VIG MPW + +DL FK T PV+MG T++SIGR LPGR NII Sbjct: 6 IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNII 65 Query: 62 L----SSQPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 + + + + S+ ++ +A+ +I +IGGG +Y Q + A LY+THI Sbjct: 66 ITRDNTRRASVNPEAVLASSILDSLDLASKTGSKKIFIIGGGEIYAQTISLAHTLYITHI 125 Query: 116 DAEVEGDTHFPDYEPDDWE 134 + E+EGD FP + + W+ Sbjct: 126 EKEIEGDVFFPSIDSNIWK 144 >UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE Length = 167 Score = 105 bits (263), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 66/167 (39%), Positives = 92/167 (55%), Gaps = 12/167 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LI A A + VIG +N MPW+LP D+A FK T VIMGR TW+S+ RPLPGR Sbjct: 3 IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPPRFRPLPGRS 62 Query: 59 NIILSSQPG-----TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYL 112 NI+++ Q D+V S+ EA+ ++ + + VIGG ++Y Q LP A + + Sbjct: 63 NIVVTRQADWQAEPASDQVLRAASLSEALELGRNLSQDVWVIGGAQIYAQALPLADAVEV 122 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I + EGD P+ + W++V H + N YCF ERR Sbjct: 123 TEIGRDFEGDAFAPELG-EQWQAVSRSEH--VSANGLPYCFVRFERR 166 >UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=A0Z2N0_9GAMM Length = 184 Score = 105 bits (263), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 60/161 (37%), Positives = 89/161 (55%), Gaps = 15/161 (9%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+ A++ + VIG NA+PW+LP DL FK+ T+ P++MGR T+ES+GRPLPGR N++ Sbjct: 13 VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLV 72 Query: 62 LS-----SQPGTDDRVTWVKSVDE------AIAACGDVPEIMVIGGGRVYEQFLPKAQKL 110 L+ PG VT SVD+ A A + V+GG +Y LP+A ++ Sbjct: 73 LTRDSTWQAPG----VTIFSSVDKALALAEAQALIDGASAVCVVGGAEIYRLCLPRADRI 128 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151 LT + +V GD F + W+ E A+NSH + Sbjct: 129 LLTLVHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDF 169 >UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA Length = 166 Score = 105 bits (262), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 63/159 (39%), Positives = 88/159 (55%), Gaps = 9/159 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I+LI A A + VIG NAMPW+LP DLA FKR T PVIMGR TW+S+ RPLPGR Sbjct: 6 INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65 Query: 59 NIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N++++ QP S+ +A+A C E+ VIGG ++Y P A ++ +T I Sbjct: 66 NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQ 125 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 + +GD P ++W+ E H +SH F + Sbjct: 126 DFDGDAFAPPLG-EEWQETAREAH----VSSHGLPFSFV 159 >UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MBL2_9PORP Length = 173 Score = 105 bits (262), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 63/163 (38%), Positives = 89/163 (54%), Gaps = 6/163 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I +I A A DR IG + MPW L DL K T VIMGRHTW+SIG RPLP R NI Sbjct: 3 IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGARPLPNRYNI 62 Query: 61 ILS-SQPGTDDRVTWVKS-VDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++S + P D +V S +++A+ C + ++GGG +Y+ LP A L LT +D Sbjct: 63 VVSRTLPEGDAETHYVASTLEQALQHCQQAGYDRVYIMGGGVLYKSGLPYATHLNLTMVD 122 Query: 117 AEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V + DTHFP+ +W + + AD +N + + +R Sbjct: 123 TVVPDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR 165 >UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A0W8_PELCD Length = 167 Score = 105 bits (261), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 59/148 (39%), Positives = 84/148 (56%), Gaps = 11/148 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++++ A+ +R+IG +PW++P DLA F+R T ++MGR T+ESIGRPLPGR NI+ Sbjct: 16 MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIV 75 Query: 62 LSSQ--PGTDDRVT--WVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +S P RV + +++ A GD I IGG +Y Q L A KL ++ I Sbjct: 76 VSRSMPPVEGLRVCRHFAEALQVADQGNGD---IFFIGGCEIYRQALIVAGKLSVSWIRK 132 Query: 118 EVEGDTHFPDYEPDDW----ESVFSEFH 141 GD FP+Y DDW E +SEF Sbjct: 133 NYPGDCRFPEYRSDDWLIEQEQDYSEFR 160 >UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9 Length = 198 Score = 104 bits (259), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 60/169 (35%), Positives = 92/169 (54%), Gaps = 15/169 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++++AALA +RVIG+ AMPW+LP D F+ T KP++MGR T+ESIGR LPGR+ I+ Sbjct: 25 LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIV 84 Query: 62 LS-----SQPGTDDRVTWVKSVDEAIAACGDVPEIM------VIGGGRVYEQFLPKAQKL 110 L+ + PG V ++ A+ D IM ++GGG ++ LP+ ++L Sbjct: 85 LTRDETFAAPG----VLVAHDLEGALGLAHDWARIMGAKTIILVGGGELFAALLPRVERL 140 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 LT ++ +GDT FP + WE ++ SY F R+ Sbjct: 141 ELTLVEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK 189 >UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FSY3_9FIRM Length = 169 Score = 104 bits (259), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 59/162 (36%), Positives = 89/162 (54%), Gaps = 3/162 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M++L+ A IG +N +PW+LP DL +FK+ TL ++MGR T+ES+G R LPGR + Sbjct: 1 MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGCRLLPGRTS 60 Query: 60 IILSSQPGTDDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+ Q + + V EAI A + E+MVIGG ++ LP A ++ T I A Sbjct: 61 YVLTRQEDYKSEIEGLHRVHNLEAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIKA 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DT D + D W+ V + D +N +++ FE RR Sbjct: 121 TFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR 162 >UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D395_9BACT Length = 201 Score = 103 bits (257), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 56/164 (34%), Positives = 84/164 (51%), Gaps = 39/164 (23%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQP- 66 ++++RVIG +N +PW+LP D WFK+ T V+MGR T+ES+GRPLP R NI+++ +P Sbjct: 1 MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPL 60 Query: 67 ---------------------------------GTDDRVTWV----KSVDEAIAACGDVP 89 +R W+ + + +A Sbjct: 61 RLARDPQFKATVGQARVGHWQARFGRPYQLGFERLSERDVWLVRDPRKLADAFEKARPSR 120 Query: 90 EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDW 133 ++ VIGG ++YEQ LP+ LYL+ + EVEGD FP+ E DDW Sbjct: 121 QLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPELE-DDW 163 >UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIZ1_FIBSS Length = 163 Score = 103 bits (256), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 61/164 (37%), Positives = 92/164 (56%), Gaps = 8/164 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS I A++ + VIG + +PW+L ADL FK T +I+GR ++ IGRPLP R N Sbjct: 2 LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNY 61 Query: 61 ILSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +L+ PG + +++ EA A G+ E +IGG VY + +P +KLYLT + Sbjct: 62 VLTRNKDFQAPGCIVCSSLGEAI-EAARAAGET-ECFIIGGAAVYREAMPLVEKLYLTRV 119 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + VEGD FP++ D ++ +E AD +N FEI R+ Sbjct: 120 LSHVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK 162 >UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK Length = 166 Score = 103 bits (256), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 54/150 (36%), Positives = 82/150 (54%), Gaps = 4/150 (2%) Query: 14 IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTD---D 70 IG + W+LP DL FK T+N ++MGR TW++IGRPLPGR +++L+ Q D Sbjct: 16 IGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLVLTHQKDFKTPYD 75 Query: 71 RVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYE 129 V SVDE + + +I + GG +Y F+P A L +T ID + GDT + Sbjct: 76 DVIIAHSVDEVLDYIEKETRDISIAGGAAIYHAFMPYATDLIVTRIDVTIAGDTFVDAID 135 Query: 130 PDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ V + HD D ++ +S+ E ER+ Sbjct: 136 LSQFKLVSATAHDKDDKHDYSFVVERYERQ 165 >UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP Length = 170 Score = 102 bits (255), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 51/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 +S+I A+A + IG +N + W+LP DL FK T +IMG++T+ S+ LP R+NI Sbjct: 3 LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPNGALPNRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 ++SS D V ++ A+ A E+ +IGG ++Y LP A K+Y + ++ Sbjct: 63 VVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFP 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT+FP+++ +W + + D +N ++ I +R Sbjct: 123 EADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR 161 >UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST Length = 163 Score = 102 bits (253), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 57/137 (41%), Positives = 84/137 (61%), Gaps = 6/137 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+LI A A + IG +N +PW+ P DL F+R TL +IMGR+TW+S+ +PL R N Sbjct: 1 MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPFKPLKNRFN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I++SS P D V V S+DEAI A + IGG +Y+ L +A +L +T +D Sbjct: 61 IVVSSNPDAADTV--VASLDEAIDLARSEGYARLYGIGGAGIYKGMLARADRLMITEVDL 118 Query: 118 EV-EGDTHFPDYEPDDW 133 E+ + D FP++ P++W Sbjct: 119 EIDDADAFFPEFPPEEW 135 >UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4 Length = 172 Score = 101 bits (251), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 59/171 (34%), Positives = 91/171 (53%), Gaps = 16/171 (9%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG++ +PW LPAD+A FK T+ P+IMGR T+ S+ R LP RK+I Sbjct: 1 MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHI 60 Query: 61 ILS------SQPGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQ 108 +L+ + +D+VT + S IA GD ++ +GG +++ L + Sbjct: 61 VLTHDQDLKKKYQDNDQVTIINS----IAELGDYIQNHQGEKLCTVGGVSIFKALLDQVD 116 Query: 109 KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 L T IDA E DT P+ + D ++ V E H+AD +N + Y F +R+ Sbjct: 117 VLEKTEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK 167 >UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonellaceae RepID=D1BNV5_VEIPT Length = 164 Score = 100 bits (250), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 58/156 (37%), Positives = 87/156 (55%), Gaps = 4/156 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M++LI A+A +RVIG +N + W+LP DL +FK T +IMGR T+ES+ LP R++ Sbjct: 1 MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHW 60 Query: 61 ILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +++ G D + V + + A A + VIGG +VYE FLP +Y+T +D E Sbjct: 61 VITRDKGFDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHE 120 Query: 119 VEGDTHFPDYEPDDW--ESVFSEFHDADAQNSHSYC 152 +GD FP++ D + ESV D Q H + Sbjct: 121 FDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFV 156 >UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AYS8_STRM9 Length = 156 Score = 100 bits (250), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 51/161 (31%), Positives = 95/161 (59%), Gaps = 10/161 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI ++ A+ + IG +N M W+ +L +F++ TLN ++MG++T+ SIGRPL R+NI Sbjct: 1 MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIM-VIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S+ ++ + ++++D+ + D EI+ VIGG +Y+QFL +K+YL+ ID + Sbjct: 61 VISTTLEENEDIYVLRNIDKILEKYVDSDEIIYVIGGENIYKQFLKYTEKIYLSKIDGKF 120 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D +FP D++ + + N +++ I RR Sbjct: 121 PDADRYFPSINYDEYST--------EVVNYNTFKLYIYTRR 153 >UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA Length = 169 Score = 100 bits (248), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 57/174 (32%), Positives = 95/174 (54%), Gaps = 21/174 (12%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 +++ + A + +RVIG + +PW+LP D+ +F+ T +IMGR T++S GR LP R + Sbjct: 2 ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRYH 61 Query: 60 IILSSQPGTDDR-------VTWVKSVDEAI-------AACGDVPEIMVIGGGRVYEQFLP 105 I+++ P V +V S++EA+ A GD E+ +IGGG +Y+Q +P Sbjct: 62 IVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGD--EVFIIGGGEIYKQAMP 119 Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 K+YLT I E GDT++P+ + E VF++ D + + F R+ Sbjct: 120 ITDKIYLTLIHREFPGDTYYPEID----EKVFTQTERRDIETPIPFSFLTYLRK 169 >UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8 Length = 164 Score = 100 bits (248), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 56/155 (36%), Positives = 90/155 (58%), Gaps = 3/155 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 IS+I A+A + IG EN + + LP DL FK T +IMGR T+ES+ + LP R+NI Sbjct: 3 ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKGALPNRRNI 62 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAE 118 +LS + G +++ A++ C + EI +IGG +Y++ + AQ+LY+T I D Sbjct: 63 VLSRREGAVFAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIDDTS 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153 E D +FP+ + ++W+ E H D ++ + Y F Sbjct: 123 KEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSF 157 >UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0 Length = 227 Score = 100 bits (248), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 63/144 (43%), Positives = 83/144 (57%), Gaps = 18/144 (12%) Query: 2 ISLIAALAVDR-----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53 ++LI A A D+ IG E MPW+LP DL FK T++ PVIMGR TWE++ RP Sbjct: 37 VNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRP 96 Query: 54 LPGRKNIILSSQ-----PGTDDRVTWVKSVD----EAIAACG-DVPEIMVIGGGRVYEQF 103 LP R NI+LS PG +++D EAI G D EI VIGG +++ Q Sbjct: 97 LPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQM 156 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD 127 LP A K+Y+T +DA+V D + PD Sbjct: 157 LPMASKIYMTQVDAKVNADAYAPD 180 >UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA Length = 181 Score = 99.8 bits (247), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 64/169 (37%), Positives = 91/169 (53%), Gaps = 12/169 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 +I +I A A + VIG + MPW+LP D F+R T VIMGR TWES+ RPLPGR Sbjct: 7 VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPEPFRPLPGR 66 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQ--FLPKAQKLY 111 +N++++S P + S+ A+AA P ++ +IGGG VY + FL A Sbjct: 67 RNLVITSDPAWSAPGAVRSSSILNALAAAAGQPGSDQVWIIGGGMVYREALFLRAANTAV 126 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSE--FHDADAQNSHSYCFEILER 158 +T I ++++GDT+ P+ P DWE +E A N Y E R Sbjct: 127 ITLIASDIDGDTYAPELGP-DWEMASAEPGVGWTTAANGTRYRIETWTR 174 >UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN Length = 168 Score = 99.8 bits (247), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 52/153 (33%), Positives = 92/153 (60%), Gaps = 8/153 (5%) Query: 13 VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNIILSSQPGTDDR 71 VIG EN +PW+LPA+L FK TLN ++MGR T++ +GR LP R+ +IL+ P +++ Sbjct: 16 VIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNP--EEK 73 Query: 72 VTWVKSVDEAIAAC----GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP- 126 + V + + + + +IGG ++++ F P ++ +THI A VEGDT+FP Sbjct: 74 IDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPE 133 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + + +E+V S+F+ D +N + + + +R+ Sbjct: 134 ELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK 166 >UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobacterium RepID=C4L1C8_EXISA Length = 162 Score = 99.8 bits (247), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 55/159 (34%), Positives = 89/159 (55%), Gaps = 3/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS + A +R IG +N + W LP DL FK T V+MGR T+ESIG+ LP R+NI Sbjct: 1 MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNI 60 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++S + D+V +D +A E VIGG +YEQ +P ++Y T + A Sbjct: 61 VVTSDVSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASF 119 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT++P+ + +W + H D +++++ F+ ++ Sbjct: 120 EADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK 157 >UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA Length = 161 Score = 99.0 bits (245), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 56/157 (35%), Positives = 90/157 (57%), Gaps = 4/157 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS+I A + IG + ++PW++P D+A+FK+ T V+MGR T++SIG+ LP RKNI Sbjct: 1 MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +LS P + D V V S+ E A P + +IGG +Y L +A +L +T I Sbjct: 61 VLSHHPTSLPDSVVGVGSLSELQAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQK 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFE 154 + + + PD ++++ S H++ +N +Y FE Sbjct: 121 DYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFE 156 >UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37 RepID=A3K5B9_9RHOB Length = 153 Score = 98.6 bits (244), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 59/131 (45%), Positives = 78/131 (59%), Gaps = 6/131 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 MI+LIAA +R IG + +PW++P DLA FKR TL ++MGR TWES+ +PL R N Sbjct: 1 MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPFKPLKDRLN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I++S + V V SV++AIA I IGG R+YE LP A +L +T +D Sbjct: 61 IVVSRDTSLHEHV--VGSVEDAIALAQSQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDT 118 Query: 118 EV-EGDTHFPD 127 V E D FPD Sbjct: 119 VVEEADAFFPD 129 >UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae RepID=C7N8V9_LEPBD Length = 173 Score = 98.6 bits (244), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 53/163 (32%), Positives = 92/163 (56%), Gaps = 21/163 (12%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M SLI A+ + IG N + W++P DL FK+ T+ K VIMG++T++SIG+PLP RKNI Sbjct: 1 MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNI 60 Query: 61 ILSSQPG------TDDRVTWVKSVDEAIAACGDVP-----------EIMVIGGGRVYEQF 103 +LS P +DR + ++ + + C ++ EI +IGGG +Y++ Sbjct: 61 VLSRNPLEIEEKIKEDRKKY-ENENTKLELCDNLQKIIDKYKNSEEEIFIIGGGEIYKKA 119 Query: 104 --LPKAQKLYLTHID-AEVEGDTHFPDYEPDDWESVFSEFHDA 143 + +++Y++H++ ++ DT+FP + W + E +D Sbjct: 120 FEMKIVKRIYMSHVNFSDKNADTYFPKIDLKKWVVITKENYDG 162 >UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614 RepID=A1SJ32_NOCSJ Length = 160 Score = 98.6 bits (244), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 55/144 (38%), Positives = 78/144 (54%), Gaps = 2/144 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A + VIG +PW LP + FK T ++MGR T++SIGRPLPGR I+ Sbjct: 8 VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIV 67 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ P V A A D E+MV GGG+VY LP A + L+ +D E Sbjct: 68 LTRSPDWSAEGVHVAHDLPAALALADTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEP 127 Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143 +GD +P+++ +W E HD Sbjct: 128 QGDAFYPEFDRSEWRETAREQHDG 151 >UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacteria RepID=DYR13_ECOLX Length = 165 Score = 98.6 bits (244), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 58/162 (35%), Positives = 84/162 (51%), Gaps = 10/162 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+AA+ +RVIG +PW +P + F+R T +K V+MGR T+ESIG+PLP R ++ Sbjct: 8 IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVV 67 Query: 62 LSSQPGTD----DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 LS Q G V+ + V + A G E+ V G VY LP A ++L+ + Sbjct: 68 LSRQAGYSAPGCAVVSTLSHVSPSTAEHGK--ELYVARGAEVYALALPHANGVFLSEVHQ 125 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP ++E V SE Q + +Y + RR Sbjct: 126 TFEGDAFFPVLNAAEFEVVSSE----TIQGTITYTHSVYARR 163 >UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organisms RepID=Q2S5H3_SALRD Length = 186 Score = 98.2 bits (243), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 63/138 (45%), Positives = 85/138 (61%), Gaps = 13/138 (9%) Query: 2 ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPG 56 + +IAA+A D RVIG + +PW++P DL FK+ T P++MGR T+ESI G PLP Sbjct: 21 LVIIAAVAEDNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIVHQFGGPLPD 80 Query: 57 RKNIILSSQPGTDD-----RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLY 111 RK ++L++Q DD V SVD A+AA D + + GG VYEQFLP A +L Sbjct: 81 RKMVVLTTQ---DDYEAYPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLE 137 Query: 112 LTHIDAEVEGDTHFPDYE 129 LT ++ EGDT FP +E Sbjct: 138 LTLVEGAYEGDTFFPPFE 155 >UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica RepID=Q7UIC9_RHOBA Length = 195 Score = 97.8 bits (242), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 61/163 (37%), Positives = 88/163 (53%), Gaps = 11/163 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ + A + VIG + MPW L +DL FK+ T+ +IMGR T+ESIGR LPGR+ I+ Sbjct: 31 ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIV 90 Query: 62 LSSQ-----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 L+ Q PGT EAIA D I V+GGG++Y+Q+ P +L+ T + Sbjct: 91 LTRQGHWQFPGTQT----ASGKSEAIALAADR-RIFVVGGGQIYQQWFPLCTELWWTRVW 145 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 A V GDT D D++E V A++ + + + RR Sbjct: 146 ANVSGDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR 187 >UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organisms RepID=A1TM51_ACIAC Length = 165 Score = 97.4 bits (241), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 60/165 (36%), Positives = 88/165 (53%), Gaps = 9/165 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + LI A A + IG+ NAMPW+LP DLA FK+ TL V+MGR TW+S+ RPLPGR Sbjct: 3 LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRT 62 Query: 59 NIILSSQPG-TDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 NI+++ Q G D S+++A+ GD + V+GG ++Y Q LP A + +T Sbjct: 63 NIVVTRQAGWHADGALSASSLEQAVELARPHGDT--VWVMGGAQIYAQALPMADGVEVTE 120 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 I + E D P P+ E+ + + + + F RR Sbjct: 121 IHRDFEADAFAPVLGPEWEETARTPVQTSAGSAALPFSFVSYRRR 165 >UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WYQ0_HALHL Length = 164 Score = 97.4 bits (241), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 62/161 (38%), Positives = 81/161 (50%), Gaps = 8/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+A + + VIG + PW+ DL FK T PVIMGR T +IGRPLP R NI+ Sbjct: 4 IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIV 63 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVP----EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 L+ PG V + EA A +M++GGG VY FLP+A +L LT +D Sbjct: 64 LTRDPGFHADGVEVATDPEAALARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDD 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP P +W+ E + D + F L R Sbjct: 124 APPGDTTFPAIGP-EWQETAREEAEEDG---YRLTFRTLLR 160 >UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B2267 Length = 178 Score = 97.1 bits (240), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/162 (40%), Positives = 88/162 (54%), Gaps = 8/162 (4%) Query: 3 SLIAALAVDRVIGMENAMPW--NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 ++I A +R IG +PW +LPADLA FK+ T +IMG T+ESIG RPL RKN Sbjct: 17 AIIVAYDRNRAIGRGGDLPWGRSLPADLAHFKQLTKGGGIIMGHRTFESIGSRPLLERKN 76 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 I++SS+P + V V + A+A +IGG RVY L P+ +Y T IDA Sbjct: 77 IVISSRPTDSEGVLTVMDLPSALALSH--YSTFIIGGARVYADALETPEIDTIYATEIDA 134 Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 G DT FP+ + W+ H ADA N + + F I +R Sbjct: 135 SFPGADTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR 176 >UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2 Length = 157 Score = 96.7 bits (239), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 50/152 (32%), Positives = 86/152 (56%), Gaps = 3/152 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI LI A + + VIG +PW + + +FK T+ V+MGR ++E IG PLP R+NI Sbjct: 1 MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + + + V S+ EA+ A D I + GG VY++ +P +Y+T +D + Sbjct: 61 IVSKTMKYEGENLITVSSLAEAL-ALSDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNI 119 Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHS 150 E GD FP+++ +D++ + E + + + + Sbjct: 120 EDGDVFFPEFDVNDFDLIIGETFGENTKYTRT 151 >UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW Length = 166 Score = 96.7 bits (239), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 53/144 (36%), Positives = 86/144 (59%), Gaps = 9/144 (6%) Query: 1 MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58 ++SLIAA+ IG+ MPW ++ D+ +F+ T VIMGR T+ES+G +PLP RK Sbjct: 2 IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTGYAVIMGRVTFESLGSKPLPNRK 61 Query: 59 NIILSSQPGTD-----DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLY 111 NI++SS T+ D + + KS +++I+ +I +IGG +Y++ L A +Y Sbjct: 62 NIVISSNVNTELLNKYDNLFYEKSFEDSISKLLLEKNKQIFIIGGESIYKKALDYADMIY 121 Query: 112 LTHIDAEVEGDTHFPDYEPDDWES 135 LTHID + D FP+ + + ++S Sbjct: 122 LTHIDKDYHCDRFFPEIDTNLFQS 145 >UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD Length = 171 Score = 96.3 bits (238), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 61/140 (43%), Positives = 77/140 (55%), Gaps = 8/140 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MI L+ A + + VIG +PW +P DLA F T V+MGR TWES+ RPLPGR Sbjct: 1 MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +N++LS PG + V + A+A GDV VIGG VY L A L +T +D Sbjct: 61 RNLVLSRDPGYAAEGAEVVHDLPGALAGAGDV---WVIGGSAVYRAALEHADVLVVTEVD 117 Query: 117 AEVEGDTHFPDYEPDDWESV 136 VEGDT P+ P WE V Sbjct: 118 LVVEGDTRAPEVGP-GWERV 136 >UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C2_9FIRM Length = 159 Score = 95.9 bits (237), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 47/130 (36%), Positives = 80/130 (61%), Gaps = 2/130 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LIAA+ +R +G N M W+LP DL +F++ T ++MGR T+ES+ LP R +++ Sbjct: 3 LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVV 62 Query: 62 LS-SQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +S + + + +SV+E + DV EI IGGG +Y + L A +L LT IDA+ Sbjct: 63 ISRTCKDLGEDIEMCESVEEFMKRYKDVDEEIYCIGGGMIYSEMLKYASRLVLTQIDADA 122 Query: 120 EGDTHFPDYE 129 + + +FP+++ Sbjct: 123 DAEVYFPEFD 132 >UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI0001874368 Length = 176 Score = 95.5 bits (236), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 60/145 (41%), Positives = 78/145 (53%), Gaps = 15/145 (10%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 + +I A + +IG MPW+LP DL FK T+ PVIMGR TW+S+ RPLPGR Sbjct: 14 FVGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNPKFRPLPGR 73 Query: 58 KNIILSSQ----PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +NI+LS PG + S++ A+AA D P +IGGGRVY L A + +T Sbjct: 74 RNIVLSRSVSDFPGAES----ATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVT 129 Query: 114 HIDAEVEGDTHFPDYEPD--DWESV 136 ID +V P PD DW V Sbjct: 130 DIDTDVS--VPVPVMAPDLYDWVRV 152 >UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD Length = 162 Score = 95.5 bits (236), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 56/147 (38%), Positives = 83/147 (56%), Gaps = 2/147 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 ++LI A ++ IG +N +PW++ AD+ FK T P+IMGR T+ S+G +PLP R+NI Sbjct: 4 LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGNKPLPKRENI 63 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+S+ + V V S+ P E VIGG +Y+Q LP A KL T I+ ++ Sbjct: 64 VLTSRNIDAEGVEVVHSLAALKEYLKANPNEYFVIGGATIYQQLLPMATKLTRTVINKQI 123 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQ 146 GDT P + D W V ++ D Q Sbjct: 124 VGDTKMPTIDYDRWHLVNHNNYEKDDQ 150 >UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1 Length = 167 Score = 95.1 bits (235), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS + A IG + +PW LPADLA FK T+ P++MG+ T++S LP R++I Sbjct: 1 MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHI 60 Query: 61 ILSSQPGTDDR------VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYL 112 +L+ +++ V + S+DE + + E+ VIGG ++ L K KLY Sbjct: 61 VLTHDTNLEEKYKDNPQVEIMNSIDELTSWLDENQFQEVSVIGGAMLFNLLLNKVDKLYK 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I +E GDT P D+++ V + D +N + Y F ER+ Sbjct: 121 TEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK 167 >UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS Length = 166 Score = 95.1 bits (235), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 54/167 (32%), Positives = 93/167 (55%), Gaps = 13/167 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 MI+ + A + +IG + +PW LP DLA FKR T+N+ VIMGR T++S+ +PLPGR+N Sbjct: 1 MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPKKPLPGRQN 60 Query: 60 IILSSQPGTDDRVTWVKSV------DEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLY 111 I+++ Q G +T K V + + + P ++ +IGG +++ F LY Sbjct: 61 IVITRQSG----LTVAKDVLVFNERTQLLDYQKEHPMQKLFIIGGADIFKLFAADVDYLY 116 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +T I + +GD + P + ++ + + D +N + + FEI +R Sbjct: 117 VTKIAEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR 163 >UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC Length = 175 Score = 95.1 bits (235), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 56/161 (34%), Positives = 89/161 (55%), Gaps = 3/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M++ I A + +IG E+ +PW LP DL +FK+ T ++MGR T+E +G RPLP R+ Sbjct: 1 MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGSRPLPNRQT 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGR-VYEQFLPKAQKLYLTHIDA 117 I+L+ + V + SV++ +A + I I GG VY++FLP LY T I Sbjct: 61 IVLTRDSSYKAEGVHVMHSVEDVLALEKETDGIFFIAGGSAVYQEFLPFCTILYRTVIHH 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD +FP + DW + + + D +N + + FE +R Sbjct: 121 VFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR 161 >UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA Length = 171 Score = 94.4 bits (233), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 60/167 (35%), Positives = 86/167 (51%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI I A D IG + +PW+LPADL FK T N ++MGR T+ES LP R++I Sbjct: 3 MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHI 62 Query: 61 ILSSQPGTDDR------VTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYL 112 ILS+ P + V + E D E I +IGG RV+E+F+ + + Sbjct: 63 ILSTSPTLQRKYQNNAHVKIFSQLKELKNWIKDHSEQTIDIIGGARVFEEFMDEVDMIEK 122 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I +GDT P +D+E + ++ H AD +N +Y F ER+ Sbjct: 123 TKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK 169 >UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocaceae RepID=B9YFM0_ANAAZ Length = 166 Score = 94.4 bits (233), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 56/175 (32%), Positives = 92/175 (52%), Gaps = 29/175 (16%) Query: 1 MISLIAALAVDRVIG------MENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPL 54 +ISLIAA++ +R++ + +PW++P+DL F++ T PVI+GR ++ + PL Sbjct: 3 LISLIAAISENRILADSKKEHIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPL 62 Query: 55 PGRKNIILSSQ-----PGT------DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQF 103 P R NIIL+ PG + VTW K + EI + GGG ++ + Sbjct: 63 PNRTNIILTRSHDYKAPGCLVFYSLSEAVTWAK--------MSEKEEIFIAGGGEIFAEA 114 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A KLYLT ++ EGD +FP++ ++ +V E H +N + F +ER Sbjct: 115 IKFANKLYLTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER 165 >UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI Length = 162 Score = 94.0 bits (232), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 52/129 (40%), Positives = 76/129 (58%), Gaps = 4/129 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + LI A A + VIG + +PW+LP D+A F++ T VIMGR TW+S+ RPLPGR Sbjct: 3 LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRS 62 Query: 59 NIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 NI+++ Q D S+++A+A C VIGG ++Y Q LP A + +T I+ Sbjct: 63 NIVVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQ 122 Query: 118 EVEGDTHFP 126 + +GD H P Sbjct: 123 DFDGDAHAP 131 >UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium RepID=D2Q8R3_9BIFI Length = 224 Score = 93.6 bits (231), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 60/144 (41%), Positives = 79/144 (54%), Gaps = 18/144 (12%) Query: 2 ISLIAALAVDR-----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53 ++LI A A D+ IG E MPW LP D+ F T++ PVIMGR TWE++ RP Sbjct: 39 VNLIWAQARDKEGRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSPKFRP 98 Query: 54 LPGRKNIILSSQPG-TDDRVTWVKSVD--------EAIAACG-DVPEIMVIGGGRVYEQF 103 LP R NI++S P + T V ++D EAI G D EI +IGG +V+ Sbjct: 99 LPNRDNIVISHDPAYSAPGATVVDTLDDALDLARQEAIPDDGLDRSEIWIIGGAQVFRDA 158 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD 127 LP A K Y+T I V+ DT+ PD Sbjct: 159 LPFADKAYVTQISMHVDADTYAPD 182 >UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RRK6_9EURY Length = 181 Score = 93.6 bits (231), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 61/168 (36%), Positives = 89/168 (52%), Gaps = 20/168 (11%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60 I A+A + VIG + MPW++PADL FK T++ P+IMGR T+E I G PLPGR + Sbjct: 19 IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGILEALGEPLPGRTTV 78 Query: 61 ILSSQP-GTDDRVTWVKSVDEAIAACGD--------VPEIMVIGGGRVYEQFLPKAQKLY 111 +L+S+ T + +S++EA+ A I V GG VYEQFL +L Sbjct: 79 VLTSRDLETPENAVTARSLEEALEAAETAARERHDAADRIFVAGGATVYEQFLSALDRLI 138 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +T + E +GDT+FPD++ + F D + + F RR Sbjct: 139 VTEVHEEPDGDTYFPDWDR-------ASFDDVSRDDRDGFAFVEYVRR 179 >UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA Length = 163 Score = 93.6 bits (231), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+ + A + RVIG+ +PW+LPAD+ +FK T ++ G T+ S RPLP RKNI Sbjct: 1 MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNI 60 Query: 61 ILSSQPGT--DDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++S QP T + V+ + S+ A AA +I V+GG +++ L LY T ID Sbjct: 61 VVSHQPATAFPENVSVLHSLPAVRAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 A +GDT P + + + + + +N + + FE +R Sbjct: 121 AGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR 162 >UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus faecium RepID=C2HC06_ENTFC Length = 172 Score = 93.6 bits (231), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 53/161 (32%), Positives = 92/161 (57%), Gaps = 6/161 (3%) Query: 4 LIAALAVDR--VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I+ A DR +IG +PW LP D+ +F+ +T+++ ++MGR T+E +G LP R I Sbjct: 2 FISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLSLPYRHII 61 Query: 61 ILSSQPG--TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L++QP T + + S+DE +A + E I V GG R++++ LP +++ T ID+ Sbjct: 62 VLTTQPNFRTKENAEVMHSIDELLAYSQTISEDIYVSGGSRIFQELLPYTGRIWRTLIDS 121 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT+ D + D+ + D +N +++ F+ ER Sbjct: 122 TFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER 162 >UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis RepID=Q3F0Y0_BACTI Length = 172 Score = 93.2 bits (230), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 59/172 (34%), Positives = 83/172 (48%), Gaps = 14/172 (8%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MISLI A + IG EN + L D+ F + T KP+IMG T+ S+G +PL R N Sbjct: 1 MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGHKPLKDRFN 60 Query: 60 IILSSQP-----------GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQ 108 I+L+ P G + ++ + I D EI+VIGG + YE FLP A Sbjct: 61 IVLTRSPMALTLDHLHLVGENLVFESLEYIQFMIEQSKD-KEIVVIGGQQTYELFLPMAS 119 Query: 109 KLYLTHIDAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++YLT I E D++FP + +W S H N H + ER+ Sbjct: 120 RVYLTRIHHSFPEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK 171 >UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes RepID=C3XD45_OXAFO Length = 163 Score = 93.2 bits (230), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 58/164 (35%), Positives = 89/164 (54%), Gaps = 15/164 (9%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS + A+A +RVIG + MPW++P + F+ T+ K +I+GR T ESIGR LP R II Sbjct: 4 ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITII 63 Query: 62 LSSQ-----PGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S + PG V +DEAI + +I++ GGG ++ Q LP K+YL+ Sbjct: 64 VSRKKDYEVPGAH----VVHDIDEAIRLAREFGKEDIVIGGGGELFSQTLPVTDKVYLSI 119 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A+ +G+T +P+ ++ F E + S Y F ER Sbjct: 120 VHADFDGETFYPELPKEE----FVEKARKEIDASIPYAFVEFER 159 >UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PWR8_9BACT Length = 163 Score = 92.8 bits (229), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 IS+I A+A +R IG N + ++LP D+ FK T +IMGRHT++S+ L R+NI Sbjct: 3 ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLPNGALLHRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119 ++S S+++AIA+C E+ +IGG +Y Q L A ++YLT + D Sbjct: 63 VVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVDDTPT 122 Query: 120 EGDTHFPDYEPDDWESVFSEFH 141 + DT FP+ + W+ E H Sbjct: 123 QFDTVFPEIDMSHWQETKKEKH 144 >UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PCZ0_9BACT Length = 179 Score = 92.8 bits (229), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 62/184 (33%), Positives = 97/184 (52%), Gaps = 31/184 (16%) Query: 1 MISLIAALA-VDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRK 58 M+S+IA ++ V R IG +N + + +P+D+ F+ T +IMGR T+ES+ LP R+ Sbjct: 1 MLSIIACISKVHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPNGALPNRR 60 Query: 59 NIILSSQPGTDDRVTWVK---SVDEAIAACGDVP-------------------EIMVIGG 96 NI++S T +++T + S++EA+AA + E +IGG Sbjct: 61 NIVISK---TREQITGCEVYTSLEEALAARKEEAARKEEVGNKETVGSKEASDECFIIGG 117 Query: 97 GRVYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155 +YEQ LP A KLYLT ++ E E DT FP+ P +WE E + +N + F Sbjct: 118 ASIYEQALPFADKLYLTIVEKEPEHADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLT 174 Query: 156 LERR 159 L R+ Sbjct: 175 LYRK 178 >UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus faecium RepID=DYR_ENTFC Length = 167 Score = 92.8 bits (229), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 52/157 (33%), Positives = 91/157 (57%), Gaps = 6/157 (3%) Query: 4 LIAALAVDR--VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 I+ A D+ +IG + +PW LP D+ +F+ +T++K ++MGR T+E +G+ LP R I Sbjct: 2 FISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHII 61 Query: 61 ILSSQP--GTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L++Q + + S+DE +A D+PE I V GG R+++ LP+ + ++ T IDA Sbjct: 62 VLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLIDA 121 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFE 154 E EGDT + + +E V + +N + + F+ Sbjct: 122 EFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQ 158 >UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate reductasetype III) n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3 Length = 181 Score = 92.8 bits (229), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 57/156 (36%), Positives = 86/156 (55%), Gaps = 9/156 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A+ + IG NA+PW++ ADL FK T VIMGR T ES+GR LP R N +++ Sbjct: 11 VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITR 70 Query: 65 QPGTD-DRVTWVKSVDEAI-AACGDVPE-----IMVIGGGRVYEQFLPKAQKLYLTHIDA 117 D V S+++A+ AA D + +IGGG +++Q L A +L LTH+D Sbjct: 71 DINWHFDGVKIAYSIEDALNAALEDAKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDL 130 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153 +V+GD H+P P ++ SE D ++ S+ F Sbjct: 131 DVQGDAHYPTI-PSEFHKTASE-QQVDEKSGTSFEF 164 >UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EGY7_9CLOT Length = 319 Score = 92.4 bits (228), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 57/162 (35%), Positives = 87/162 (53%), Gaps = 12/162 (7%) Query: 1 MISLIAALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPG 56 MI + +AVD+ IG EN + +++P D+A+F++ TLNK V+MGRHT ES+ RPL Sbjct: 1 MIKMKCIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPKSRPLKN 60 Query: 57 RKNIILSS----QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 R NI++S Q G ++ + A++ C D ++ V+GG VY L + + Sbjct: 61 RLNIVMSRDRSLQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALI 119 Query: 113 THIDAEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCF 153 T I + E D FP+ + D +W SE D + N Y F Sbjct: 120 TKIQGQREADRFFPNIDRDNNW--TLSEQSDVRSHNGLCYSF 159 >UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2 Length = 194 Score = 92.0 bits (227), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 55/137 (40%), Positives = 75/137 (54%), Gaps = 11/137 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + L+ A VIG + MPW+LP D+ F R T PVIMGR TW S RPLPGR Sbjct: 23 VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPGRT 82 Query: 59 NIILSSQPGTDDR-----VTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQFLPKAQKL 110 NI+++ Q G D VKS+D+A+ P + V+GGG ++ Q L A Sbjct: 83 NIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIADVA 142 Query: 111 YLTHIDAEVEGDTHFPD 127 +T ID+E +GDT+ P+ Sbjct: 143 VVTFIDSETDGDTYAPE 159 >UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP Length = 165 Score = 92.0 bits (227), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 58/161 (36%), Positives = 85/161 (52%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+IAA+A IG + ++P+D+ FK T VIMGR T+ES+ PLP RKN+ Sbjct: 4 ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPVAPLPNRKNV 63 Query: 61 ILSSQPGTDDRVTW-VKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L++ P + +S+ A+ C EI +IGG VY Q L A K+Y+T I E Sbjct: 64 VLTTMPEAGFVNCFACESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEF 123 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + + FP D WE E + AD +N + Y + R+ Sbjct: 124 PDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK 164 >UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC Length = 164 Score = 92.0 bits (227), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 57/160 (35%), Positives = 85/160 (53%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 +S+IA+L + IG EN + LPADL F++ TL +IMGR T++S+ LP R+NI Sbjct: 3 LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPNGILPDRENI 62 Query: 61 ILSSQPGTDDRVTWV-KSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + V S+D A++ + E+ +IGG ++Y+Q LP LYLT + A Sbjct: 63 IISRNGSLAIKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATF 122 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E D FP +W E A+ +N + F ER Sbjct: 123 PEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER 162 >UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13 RepID=B6BUF2_9PROT Length = 148 Score = 91.7 bits (226), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 44/129 (34%), Positives = 70/129 (54%), Gaps = 2/129 (1%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 ++ + VIG++N++PW+L DL FK T ++MGR T+ESIG+PLP R N +L+ Sbjct: 1 MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRN-- 58 Query: 68 TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPD 127 +D ++ V + + +IGGG +Y Q + +L +T I E+ GD FP Sbjct: 59 SDLKIDGVHVISSLNDISDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFPM 118 Query: 128 YEPDDWESV 136 + W V Sbjct: 119 IDASVWSLV 127 >UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (class) RepID=C5CC92_MICLC Length = 186 Score = 91.7 bits (226), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 65/181 (35%), Positives = 91/181 (50%), Gaps = 29/181 (16%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 +I++I A RVIG + MPW++P DLA F+ +T PVIMGR TWES RPLPGR Sbjct: 11 VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFPARFRPLPGR 70 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGD--VPE----------------IMVIGGGRV 99 NI++S +T + + A G VP+ + VIGG + Sbjct: 71 TNIVVSRT------LTATEQAGAQLRAAGAVVVPDFGAALAAAAEADGCDTVWVIGGATL 124 Query: 100 YEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILE 157 Y+Q L A + +T IDA+V+GDTH P + + DA D+ + + FE E Sbjct: 125 YDQALDVASRAEVTVIDADVDGDTHAPPLDARWRRTAVDPAPDAWLDSASGPRHRFERWE 184 Query: 158 R 158 R Sbjct: 185 R 185 >UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO Length = 162 Score = 91.3 bits (225), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 50/135 (37%), Positives = 79/135 (58%), Gaps = 5/135 (3%) Query: 5 IAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 +AALA +RVIG + +PW ++PAD ++ + PV++GR T+ES+ LPG I++S Sbjct: 6 VAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 Query: 64 --SQPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 + + D SV+EA IAA D VIGG +Y F P ++ L+ + E Sbjct: 66 RSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEY 125 Query: 120 EGDTHFPDYEPDDWE 134 EGDT++P+++ +WE Sbjct: 126 EGDTYYPEWDAAEWE 140 >UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2 Length = 167 Score = 90.5 bits (223), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60 I I A A + VIG + MPW+LPA+LA FK+ T+ ++MGR T++ + R LPGR+ + Sbjct: 5 IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRCLPGRETL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IL+ D + VT V SV+EA+A ++ + GG VY+ F L T I+A+ Sbjct: 65 ILTRDKDFDCEEVTTVTSVEEALAWFEQQDKDLYIAGGASVYKAFDGHYDVLIKTTIEAD 124 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +EGDT+FP + ++ V + +N++ + E+ Sbjct: 125 LEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK 164 >UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934V0_SALTI Length = 158 Score = 90.5 bits (223), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 48/127 (37%), Positives = 76/127 (59%), Gaps = 6/127 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +IAA+ + IG+ N +PW P DL FK+ T N V+MGR T ES+ RPLP R N++ Sbjct: 1 MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV 60 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ G + +D+ + +P+ + VIGGG++Y F+P ++++L+HI +V Sbjct: 61 LTRSRGYIPNGFYPAGIDDVL----RLPDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVP 116 Query: 121 G-DTHFP 126 G D FP Sbjct: 117 GADAFFP 123 >UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT Length = 169 Score = 90.5 bits (223), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 56/154 (36%), Positives = 83/154 (53%), Gaps = 12/154 (7%) Query: 13 VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQ-----P 66 ++G + +PW LP DL +FK T+ + ++MGR T+E +G R LPGR+ IIL++ P Sbjct: 13 LVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGSRLLPGRQTIILTTSSDYIVP 72 Query: 67 GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 G + V + E I +I V GG +VY + LY T I A EGD++FP Sbjct: 73 GAE-----VVTNIEEIVEDSRHEDIYVCGGAQVYNLLKNHVELLYCTRIHASFEGDSYFP 127 Query: 127 DYEP-DDWESVFSEFHDADAQNSHSYCFEILERR 159 P D+ V S + D +N + + FEI ER+ Sbjct: 128 TEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK 161 >UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX Length = 157 Score = 90.5 bits (223), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 54/160 (33%), Positives = 94/160 (58%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA A + VIG +PW+ + FK T N+ +++GR T+ES+G LP RK + Sbjct: 3 VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV 61 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ T +D V S++EA+ ++ + ++V GGG +Y + LP A L+++ ID E Sbjct: 62 VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP+ P+ +E VF + ++ +YC++I ++ Sbjct: 122 PEGDVFFPNI-PNTFEVVFEQHFSSNI----NYCYQIWQK 156 >UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HP20_9RHOB Length = 154 Score = 90.1 bits (222), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 48/132 (36%), Positives = 78/132 (59%), Gaps = 2/132 (1%) Query: 7 ALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQ 65 A A + IG + +PWN+P DL +F+R TL +IMGR+TWES+ +PLP R N+++SS Sbjct: 2 ARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPVKPLPRRFNVVVSSN 61 Query: 66 PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-EGDTH 124 T + V V +A I IGG +Y++ LP A +L ++ + +V + DT Sbjct: 62 SDTAEVVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVPDADTF 121 Query: 125 FPDYEPDDWESV 136 FP+++ W+++ Sbjct: 122 FPNFDVAGWKAI 133 >UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE Length = 165 Score = 89.7 bits (221), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 55/146 (37%), Positives = 79/146 (54%), Gaps = 6/146 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 ++ LI A + VIG + MPW +P DL FK+ T+ PV+MGR TW+S+ RPLPGR Sbjct: 3 VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS Q + S++E I+ PE+ VIGG ++Y LP A + +T +D Sbjct: 63 RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122 Query: 117 AEV--EGDTHFPDYEPDDWESVFSEF 140 + E D D W V E+ Sbjct: 123 TYLLHEDDDVLAPVLDDTWVGVTGEW 148 >UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD Length = 337 Score = 89.7 bits (221), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 53/148 (35%), Positives = 80/148 (54%), Gaps = 18/148 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A+A + IG + +PW+LP DL FK T+ ++MGR T+ES RPLPGR++++ Sbjct: 168 LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVV 227 Query: 62 LSSQP----------------GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLP 105 ++S P D V +S EA+ GD E+ V+GG V+ LP Sbjct: 228 MTSDPTWLPGGPAVEGDPASGARFDEVLVARSWAEALLMAGDG-EVFVVGGAGVFADALP 286 Query: 106 KAQKLYLTHID-AEVEGDTHFPDYEPDD 132 A +L LT +D + + DT FP P D Sbjct: 287 VADRLVLTEVDQSPQDADTFFPITWPVD 314 >UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3 Length = 167 Score = 89.4 bits (220), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 51/144 (35%), Positives = 79/144 (54%), Gaps = 4/144 (2%) Query: 14 IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVT 73 IG +N MPW+L ADL FK T PVIMG++T+ S+GRPLP R NI+++ Q + VT Sbjct: 16 IGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIVVTRQTTPIEGVT 75 Query: 74 WVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEP 130 V V+ + +A G+ E+ +IGG ++ + A LY T ++ + GD + Sbjct: 76 LVNGVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGDHHGDVKMAPIDY 135 Query: 131 DDWESVFSEFHDADAQNSHSYCFE 154 W+ V +E H ++ + FE Sbjct: 136 RTWQKV-AERHLQATESDPACTFE 158 >UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SDU7_9ACTO Length = 176 Score = 89.4 bits (220), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 55/129 (42%), Positives = 79/129 (61%), Gaps = 5/129 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + L+ A A VIG + +PW+LP DL F+ T V+MGR TWES+ RPLPGR+ Sbjct: 3 VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGRR 62 Query: 59 NIILSS-QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N++L++ + D V V++ +A D ++ VIGGGRVY FLP A ++ +T +D Sbjct: 63 NVVLTTDRSWAADGAERVDGVEDVLARTDD-GDLWVIGGGRVYAAFLPHADRVVVTDVDT 121 Query: 118 EVEGDTHFP 126 +VEGDT P Sbjct: 122 DVEGDTWAP 130 >UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK Length = 162 Score = 89.4 bits (220), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 52/160 (32%), Positives = 82/160 (51%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG +N +PW+LPADL FKR T + ++MGR T++S+G PLP RKN+ Sbjct: 1 MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNV 60 Query: 61 ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ S+ + + S+D+ + I VIGG ++ K +T ID + Sbjct: 61 VLTRSRSFQAEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKF 119 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E DT P +WE V + D +N + + + R+ Sbjct: 120 EADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK 159 >UniRef50_B3FJX9 Dihydrofolate reductase n=1 Tax=Pseudomonas phage 201phi2-1 RepID=B3FJX9_9CAUD Length = 183 Score = 88.6 bits (218), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 49/132 (37%), Positives = 79/132 (59%), Gaps = 14/132 (10%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNII 61 S+I A V VIG++N +PW++PAD+A F +T K V+MGR TWES+ +PLPGR NII Sbjct: 4 SMILARDVQGVIGIDNKLPWHVPADMALFIAHTKGKAVVMGRKTWESLPVKPLPGRHNII 63 Query: 62 LSSQPGTDD-----------RVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQ 108 L+ +P D +V+ SV++AI + E++ IGG +Y+Q + Sbjct: 64 LTGKPNYKDVVNAEELTNKAQVSIASSVEDAIISASQEGADEVVFIGGRSIYDQVVNYVD 123 Query: 109 KLYLTHIDAEVE 120 +++++ ++ VE Sbjct: 124 EIHVSELNLCVE 135 >UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q6CC38_YARLI Length = 189 Score = 87.8 bits (216), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 58/147 (39%), Positives = 81/147 (55%), Gaps = 14/147 (9%) Query: 3 SLIAALAVDRV-IGMENAMPWNLPADLAWFKRNTL---NKPVIMGRHTWESIG---RPLP 55 +LI A V R IG+ +PW L ++ +FK+ T N VIMGR TW+SI RPLP Sbjct: 6 TLILAATVPRYGIGLNGGLPWRLAKEMKFFKQVTTAQKNAVVIMGRTTWDSIPPKFRPLP 65 Query: 56 GRKNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLY 111 R NI+L+S+P TD + V +S DEA+ C + + VIGG +VY+ L + + Sbjct: 66 DRTNIVLTSRPMTDAPEEVVVARSFDEALTKCPEDSTVYVIGGSQVYKTALVHEHTKAVL 125 Query: 112 LTHI---DAEVEGDTHFPDYEPDDWES 135 LT I D VE DT F ++ W+ Sbjct: 126 LTEITCPDGHVECDTFFEGFDQGLWKK 152 >UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY Length = 170 Score = 87.0 bits (214), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 48/153 (31%), Positives = 84/153 (54%), Gaps = 6/153 (3%) Query: 13 VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQPG---T 68 +IG + +PW+LPADLA FK+ T ++MGR T++ +G R LP R I+L++ Sbjct: 16 LIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGKRALPNRHTIVLTTDKTYQLE 75 Query: 69 DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPD 127 +R+T + SV++ + + + VIGGG+++ F P + L +T I + GD +FP Sbjct: 76 SERITILHSVEDVLDWYNKQEQTLFVIGGGQIFTAFAPYIETLIVTDIHGQFNGDVYFPK 135 Query: 128 YEP-DDWESVFSEFHDADAQNSHSYCFEILERR 159 P + ++ + D +N + + + ERR Sbjct: 136 AFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR 168 >UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8NZB9_ERYRH Length = 150 Score = 87.0 bits (214), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 42/128 (32%), Positives = 75/128 (58%), Gaps = 2/128 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI +I A+ R IG+ +MPW+ DL F+++TLN+ V+MGR T+E + + L R+ Sbjct: 1 MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIY 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +++ ++ + +++ + +I + GGG +Y Q LP A +L +++I +V Sbjct: 61 VVTRNASIENAIPDLRAF--LMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDVI 118 Query: 121 GDTHFPDY 128 GDT FPD+ Sbjct: 119 GDTFFPDF 126 >UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LGH8_RHOVA Length = 178 Score = 87.0 bits (214), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/170 (34%), Positives = 90/170 (52%), Gaps = 17/170 (10%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A A + VIG E +PW L +DL F+R T+ P+IMGR T+ SIG+PL GR ++I Sbjct: 9 LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVI 68 Query: 62 -------LSSQPGTDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQ 108 +S QPG V S+ +A+ AA V E VIGG ++ LP A Sbjct: 69 VTRDAASVSPQPG----VFVATSIKDALDIARARAAERRVAEAFVIGGAEIFALALPYAD 124 Query: 109 KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +++L + A GD ++ ++W+ V E A+ + S +LER Sbjct: 125 RIHLARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER 174 >UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R3F1_JONDD Length = 191 Score = 86.3 bits (212), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 56/137 (40%), Positives = 77/137 (56%), Gaps = 9/137 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +SLI A +++ VIG +PW+ P DLA F++ T VIMGRHTWES+ PLP R NI Sbjct: 11 LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPVTPLPQRVNI 70 Query: 61 ILSS-----QPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+S PG T +++D A G I VIGG +VY+ F+ A +L +T Sbjct: 71 VLTSDRDYRAPGARVVTTPQQALDLAHWYTQVGH-QAIWVIGGRQVYDTFMDYATQLIVT 129 Query: 114 HIDAEVEGDTHFPDYEP 130 + +EGDT P P Sbjct: 130 TVGTVIEGDTEAPRIPP 146 >UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BYZ5_BEUC1 Length = 169 Score = 86.3 bits (212), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 54/167 (32%), Positives = 82/167 (49%), Gaps = 15/167 (8%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MI +I A A D VIG +PW++P D A FK T V+MGR TW+S+ RP+P R Sbjct: 1 MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +N++++ Q + D S+ +A+ C PE ++GG ++Y + +P A L +T +D Sbjct: 61 RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120 Query: 117 --AEVEGD---THFPDYEP------DDWESVFSEFHDADAQNSHSYC 152 +VEG H P P D W+ + H Y Sbjct: 121 LALDVEGAPDVVHAPPIGPEWRIATDTWDGTWQTSRTGVRWQVHQYV 167 >UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadaceae RepID=Q0G0R9_9RHIZ Length = 178 Score = 85.9 bits (211), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A A + VIG + MPW++P+DL ++ T+ KP+IMGR T E+IG+ L GR +I+L+ Sbjct: 11 VVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIVLTR 70 Query: 65 QPGTD-DRVTWVKSVDEAIAA---CGD---VPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 + D EAIA C EI V+GG +Y ++ LT +DA Sbjct: 71 ENRLAVDGAMLASGPAEAIAKAIECASARRASEIAVVGGAEIYRLLWDHIDRIALTEVDA 130 Query: 118 EVEGDTHFP 126 E EGD FP Sbjct: 131 EPEGDAVFP 139 >UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD Length = 183 Score = 85.9 bits (211), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 61/150 (40%), Positives = 83/150 (55%), Gaps = 25/150 (16%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 M+ I A + D VIG++ +PW+L DL +F R T+ PVIMGR TWES RPLPGR Sbjct: 1 MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPEQFRPLPGR 60 Query: 58 KNIILSSQPGT----DDRVTWVKSVDEA-------IAACG-----DVPEIMVIGGGRVYE 101 NI+++S+P + +RV V S EA +AA G E+ VIGG V+ Sbjct: 61 PNIVITSRPESVPADGERVWAVGSYAEALELAVSLLAAPGPEHEEPAREVWVIGGPGVWR 120 Query: 102 QF-----LPKAQKLYLTHIDAEVEGDTHFP 126 + LP + L +T +D +V GDTH P Sbjct: 121 EAVSHRPLPLTRAL-VTTVDLDVTGDTHAP 149 >UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7 Length = 181 Score = 85.9 bits (211), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 56/132 (42%), Positives = 77/132 (58%), Gaps = 8/132 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 M+ I A ++D VIG MPW++P DL FK T+ PVIMGR TWES+ RPLPGR Sbjct: 1 MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLTPKFRPLPGR 60 Query: 58 KNIILS-SQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 NI+LS +PG T V ++D A+ A D + +IGGG++Y L + + LT + Sbjct: 61 DNIVLSRREPGEWSAGATVVDNLDAALHATLD--DAWIIGGGQLYSSALDRVDTIELTLM 118 Query: 116 DAEVEGDTHFPD 127 +V GD + D Sbjct: 119 GVQV-GDAYGAD 129 >UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H0N2_9FIRM Length = 162 Score = 85.5 bits (210), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 55/160 (34%), Positives = 84/160 (52%), Gaps = 8/160 (5%) Query: 6 AALAVDR--VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPGRKNII 61 A + VD+ IG + + +L DL +FK T+ K +I+GR T ES G+PLPGRK I+ Sbjct: 3 AIVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPGGKPLPGRKTIV 62 Query: 62 LSSQPGTDDRVTWV-KSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ +V S E + D+ ++ V GGG +Y+QFL K ++T I E Sbjct: 63 LTRNTSYKAEGAYVCHSKQEVLEKVKDLHPADVFVAGGGAIYKQFLNDVDKGFVTKICNE 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP+ + D+ ++ SE + +N + F I R Sbjct: 123 YSGDTFFPNLDEDEDFALESE-GETIEENGVKFKFCIYNR 161 >UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX Length = 157 Score = 85.5 bits (210), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 53/160 (33%), Positives = 94/160 (58%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA++ + VIG +PW+ + FK T N+ +++GR T+ES+G LP RK + Sbjct: 3 LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV 61 Query: 62 L--SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 + SS +D+ V S+DEA+ + + ++V GGG +Y+ + K L+++ ID E Sbjct: 62 VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD +FP+ P + VFS+ D ++ +Y ++I ++ Sbjct: 122 PEGDVYFPEI-PSSFRPVFSQ----DFVSNINYSYQIWQK 156 >UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis RepID=C8WCM1_ZYMMN Length = 165 Score = 85.1 bits (209), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 52/124 (41%), Positives = 73/124 (58%), Gaps = 2/124 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LI A A + VIG +N MPW++ ADL FK TL P+IMGR T+ES+ LP R +I+ Sbjct: 7 IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIV 66 Query: 62 LS-SQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ + + V ++EAI A +I VIGG +++QF KA ++ LT I + Sbjct: 67 LTHNHHWQAEGAEVVCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELTEIYRDY 126 Query: 120 EGDT 123 GDT Sbjct: 127 SGDT 130 >UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetrans RepID=Q8EV82_MYCPE Length = 154 Score = 84.7 bits (208), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 47/137 (34%), Positives = 74/137 (54%), Gaps = 20/137 (14%) Query: 11 DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD 70 +R IG N +PWN+ DL FK++TLN ++MG++T+ SIG+ LP RKNI++S Sbjct: 11 NRGIGKNNKLPWNIKEDLNLFKKHTLNNTIVMGKNTFLSIGKALPNRKNIVISK------ 64 Query: 71 RVTWVKSVDEAIAACGDVPE-----------IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 T S+ + I D+ + I +IGG +Y+ F+ K LY++ +++ Sbjct: 65 --TLDASLYKDIEVYDDIEQFYNEYKNRDESIFIIGGKSIYDYFINKCSILYVSKLNSAY 122 Query: 120 EGDTHFPDYEPDDWESV 136 E D F D D +E V Sbjct: 123 ECDL-FMDNSFDGFEIV 138 >UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase protein n=1 Tax=Spiroplasma citri RepID=Q14P23_SPICI Length = 160 Score = 84.7 bits (208), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 44/141 (31%), Positives = 77/141 (54%), Gaps = 5/141 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI L+ A+ + +IG + +PW+L +L FK TL + ++ GR T+E IG PLP RK + Sbjct: 1 MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTL 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAAC-----GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +L+ + V+ V + A +I + GG ++YE LP A +L ++ I Sbjct: 61 VLTRHLDYQIKHPDVEVVTDLTAIINFYHQNPTEDIYICGGKKIYEATLPYADELIISLI 120 Query: 116 DAEVEGDTHFPDYEPDDWESV 136 + +GDT+FP ++ + + + Sbjct: 121 KGKYQGDTYFPSFDLNQFTLI 141 >UniRef50_Q7NHQ9 Dihydrofolate reductase n=1 Tax=Gloeobacter violaceus RepID=Q7NHQ9_GLOVI Length = 169 Score = 84.0 bits (206), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 52/133 (39%), Positives = 78/133 (58%), Gaps = 9/133 (6%) Query: 2 ISLIAALAVD--RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLP 55 + LIA +A+D R+IG + +PW+ P DL+ FK T +P++MGR T+ESI G+PLP Sbjct: 1 MELIAVVAMDSRRLIGRGDGLPWHCPEDLSAFKALTWGQPLLMGRRTFESILARRGKPLP 60 Query: 56 GRKNIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 R++ +L+++ G V ++ S D+A+A V + VIGG VY Q + LYL+ Sbjct: 61 EREHYVLTARRGPSFPTVRYICSPDQALAL--PVERLFVIGGASVYAQTADQLDTLYLSL 118 Query: 115 IDAEVEGDTHFPD 127 I GD PD Sbjct: 119 IPGLHTGDVFLPD 131 >UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT Length = 161 Score = 83.6 bits (205), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 52/144 (36%), Positives = 74/144 (51%), Gaps = 2/144 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +++IAA+A +R IG N M + + DL FK+ T VIMGR T+ S+ + LP R+NI Sbjct: 3 LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKGALPNRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119 +LS S+DEA+ + +IGG +Y++ L A +LYLT I D Sbjct: 63 VLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIADTPA 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143 + D FP Y W E H A Sbjct: 123 QADVFFPPYNDGTWRVESREEHPA 146 >UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phytoplasma RepID=B1V8Y8_PHYAS Length = 165 Score = 83.6 bits (205), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 46/147 (31%), Positives = 77/147 (52%), Gaps = 21/147 (14%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-----RPLP 55 MI+LI A + +IG +N +PW+ P DL +FK+ TLN+ V+MG T+ S+ +P Sbjct: 1 MINLITAFDSNYLIGSDNKLPWHYPQDLHFFKKTTLNQEVLMGHQTYLSLKSYFKDKPFN 60 Query: 56 GRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKA 107 +K + + G D +T++K+ + VIGG ++Y+Q LP Sbjct: 61 FKKTYVAARNKGLQLDGCEVVFDLLTFLKTF-----LIQKKSHLFVIGGRQIYQQSLPFV 115 Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWE 134 LY+T+I +G+ +FP P +W+ Sbjct: 116 DNLYITYILNRHKGNVYFP---PVNWQ 139 >UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marine bacterium HF10_29C11 RepID=A4GI75_9BACT Length = 168 Score = 83.6 bits (205), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 56/169 (33%), Positives = 86/169 (50%), Gaps = 14/169 (8%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL---NKPVIMGRHTWESI---GRPL 54 M+ +I A+ +D IG EN +PW L +D+ FKR T+ N V+MGR TWE+I RPL Sbjct: 2 MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQGNSAVLMGRTTWETIPERFRPL 61 Query: 55 PGRKNIILSSQPG---TDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQK 109 R NI+++ +D VT+ S++ I A+ + E +IGG VYEQ + Sbjct: 62 VDRINIVVTRNRNYALSDAHVTY--SIENGIEHASNNNCDECWIIGGADVYEQCRDLVDE 119 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++LT ++ GD + D+W E + N H + IL + Sbjct: 120 IHLTSVETSNSGDIKVGMF-GDEWNREIIESTPESSDNEHPTTYMILRK 167 >UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim resistance) n=2 Tax=Vibrio splendidus RepID=B7VPW7_VIBSL Length = 183 Score = 83.6 bits (205), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 50/160 (31%), Positives = 89/160 (55%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA+A + VIG +PW + + FK T N+ +++GR T+ES+G+ LP RK + Sbjct: 29 LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAV 87 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S P T D + + KSV++A+ V E V GGG++Y+ + + ++++ I Sbjct: 88 ISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKH 147 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + GD FP+ P D VF + ++ Y ++I ++ Sbjct: 148 ISGDIFFPEL-PRDLTLVFEQRFSSNID----YTYQIWQK 182 >UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1 Tax=Hydra magnipapillata RepID=UPI0001926A4C Length = 189 Score = 83.6 bits (205), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 22/176 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESI---G 51 + IAA+ + IG++ +PWNLP + +F+ T VIMG++TW SI Sbjct: 7 VHCIAAIDSEWGIGLKGKLPWNLPREYKFFQNITTKVISEGKQNAVIMGKNTWFSIPQQH 66 Query: 52 RPLPGRKNIILSSQPGTDD---RVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQ 102 RPL R N+ILSS +D V S++ AI D V I VIGG RVY++ Sbjct: 67 RPLKNRLNVILSSSFIKEDYPKNVLLESSLEAAILRLSDEFYANTVENIFVIGGSRVYKE 126 Query: 103 FLPK-AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ--NSHSYCFEI 155 + K K+YLT I+ + D +P ++ + ++ + E D + Q N SY F + Sbjct: 127 AMEKFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDKNKQIENGVSYTFHV 182 >UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI Length = 178 Score = 83.6 bits (205), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 49/134 (36%), Positives = 74/134 (55%), Gaps = 11/134 (8%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP-----VIMGRHTWESIG---RPLP 55 + AA R IG +N +PW LP D+ +F+ T + VIMGR TWES+ RP Sbjct: 12 IAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEIRVGVIMGRRTWESVPPKFRPFK 71 Query: 56 GRKNIILSSQPGTDDR-VTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPK-AQKLYL 112 R N++L+S+ + + +++++A+ C +V I VIGG VY + L K ++YL Sbjct: 72 NRFNVVLTSREDFEAKGAVIARTLEDAVKKCSNNVDSIWVIGGSGVYAEALNKYPCRVYL 131 Query: 113 THIDAEVEGDTHFP 126 T ID E + D FP Sbjct: 132 TEIDKEFDCDAFFP 145 >UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DQ18_9BACT Length = 149 Score = 83.2 bits (204), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 46/135 (34%), Positives = 78/135 (57%), Gaps = 6/135 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+SLI+A+ + +IG A+PW + + + K +I+GR T+E G L + Sbjct: 1 MLSLISAMDKNGLIGTGKALPWKVEEEYQRYLDTVKGKKIIVGRKTFEISGLDLKDEQVH 60 Query: 61 ILSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ILSS+ GT+ + ++++AI ACG+ +I V GG VY+ +P A +LY++ I + Sbjct: 61 ILSSRSQGTN----YYNNIEDAIKACGE-NDIFVTGGAEVYKLAMPHADRLYISVIKGDY 115 Query: 120 EGDTHFPDYEPDDWE 134 EG +FP+ + + WE Sbjct: 116 EGSIYFPNIDANIWE 130 >UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA Length = 168 Score = 82.8 bits (203), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 47/152 (30%), Positives = 86/152 (56%), Gaps = 6/152 (3%) Query: 13 VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILS---SQPGT 68 +IG + MPW+LPA+ FK T+N+ ++MGR T+E + R LPGR +IIL+ + Sbjct: 13 LIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMNKRVLPGRISIILTRDETYQSD 72 Query: 69 DDRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPD 127 +++V + S E + ++ + GG + F + + LY T + + +GDT+FP Sbjct: 73 NEKVLIMHSPKEVLDWYHKQNKDLFITGGAEILALFESELELLYRTVVHEKFKGDTYFPS 132 Query: 128 -YEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++ ++ V +FHD D +NS+++ + E+ Sbjct: 133 TFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK 164 >UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1 RepID=Q8JKV3_9VIRU Length = 264 Score = 82.4 bits (202), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 60/151 (39%), Positives = 83/151 (54%), Gaps = 16/151 (10%) Query: 2 ISLIAALAVDRV-IGMENAMPWNLPADLAWFKRNTL-----NK-PVIMGRHTWESIG--- 51 I+LI A+ + + IGM NA+PW+L ++A F + T NK VIMGR TWESI Sbjct: 87 INLIVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNKNAVIMGRLTWESIPKRF 146 Query: 52 RPLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFL--P 105 RPLPGR NI+L+++ D D T V + DEAI GD+ VIGG VY + P Sbjct: 147 RPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRGDIETAWVIGGASVYAAAMTHP 206 Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESV 136 +++LT I E + FP + +E + Sbjct: 207 NCHQIHLTAIKKYYECNVFFPKIDTTRFELI 237 >UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY Length = 160 Score = 82.0 bits (201), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 53/120 (44%), Positives = 70/120 (58%), Gaps = 12/120 (10%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M+ I A + +IG +MPW++P DL FK+ TL P+IMGR TWES+ RPLPGRKN Sbjct: 1 MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPVRPLPGRKN 60 Query: 60 IILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEI-MVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++LS + PG W + VPE VIGGG VY + K Q+++ T IDA Sbjct: 61 LVLSRRTPG-----KW----SNGASVIASVPESGWVIGGGVVYAATIDKVQEIHRTLIDA 111 >UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM 15894 RepID=D1BYH5_XYLCX Length = 185 Score = 82.0 bits (201), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 56/156 (35%), Positives = 77/156 (49%), Gaps = 23/156 (14%) Query: 1 MISLIAALAVDR----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLP 55 MI+LI A A D VIG +PW + D F+ T PV+MGR TW+S+ RPLP Sbjct: 1 MIALIWAQARDTAGRPVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPRRPLP 60 Query: 56 GRKNIILSSQPG--TDD-------------RVTWVKSVDEAIAACGDVPE---IMVIGGG 97 GR N++++ QP DD V ++DEA+ P + +IGG Sbjct: 61 GRTNVVVTRQPDWRPDDDGAVVTAGAPEATAVVVATTLDEALDGATQAPGGDLVWIIGGA 120 Query: 98 RVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDW 133 +Y Q L A +L +T ID V+GD P +P W Sbjct: 121 EIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHW 156 >UniRef50_D0NVQ6 Putative uncharacterized protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0NVQ6_PHYIN Length = 174 Score = 82.0 bits (201), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 47/145 (32%), Positives = 83/145 (57%), Gaps = 18/145 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAA +V+RVIG + +PWNLPAD A+F T N+ +++GR ++E P+P R I+ Sbjct: 8 VSLIAACSVNRVIGKQGRLPWNLPADWAFFSTATQNQVLVVGRRSFEEFDEPIPNRHTIV 67 Query: 62 LSSQ------PGTDDR---VTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPK 106 +SS T+ R V + +++++A+ P+ + V GG R+Y++ + Sbjct: 68 VSSTLQKLQVDATNARWPSVQFARTLEQALQLANTDPQYRNCNRVFVGGGERLYKEAMDS 127 Query: 107 --AQKLYLTHIDAEV-EGDTHFPDY 128 A Y++ + + +GDT FP++ Sbjct: 128 EVADSCYVSRVHQYITDGDTFFPEW 152 >UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5RC79_WEIPA Length = 168 Score = 82.0 bits (201), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 50/153 (32%), Positives = 82/153 (53%), Gaps = 4/153 (2%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNII 61 +LI A +D I ++ +PW+ ADL +FK++T+++ +MGRHT S GRPLP R N++ Sbjct: 8 NLIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFHGRPLPERLNLV 67 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ + + V SV EA + ++ VIGG +YE F+ A LY+T++ + Sbjct: 68 LTRNHDLEVPEGFQKVYSVAEAEKVADNANLKLQVIGGKPIYESFMDTADTLYVTYLQTD 127 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSY 151 GD + W+ + ADA N + + Sbjct: 128 FSGDVKMAPVDLTVWQGEVIDQGPADADNDYDW 160 >UniRef50_C7P3D4 Dihydrofolate reductase region n=1 Tax=Halomicrobium mukohataei DSM 12286 RepID=C7P3D4_HALMD Length = 157 Score = 81.6 bits (200), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 48/140 (34%), Positives = 76/140 (54%), Gaps = 7/140 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I +AA+ + VIG + +PW+LP + ++ + V++GR T+E LPG + ++ Sbjct: 3 IIAVAAVGENGVIGSGDELPWHLPHESRRYRERVADDTVVLGRKTFEMF-EELPGARQLV 61 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 LS + + T SVD AI GD P + V+GG VYE FLP+ ++ L+ +D Sbjct: 62 LSRSERSFEAETATHAASVDAAIDLARERGD-PVLYVLGGAGVYEAFLPRYDRMLLSRVD 120 Query: 117 AEVEGDTHFPDYEPDDWESV 136 E EGD FP ++ + W V Sbjct: 121 GEYEGDATFPAFDREAWTLV 140 >UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli RepID=DYR9_ECOLX Length = 177 Score = 81.6 bits (200), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 52/136 (38%), Positives = 73/136 (53%), Gaps = 11/136 (8%) Query: 1 MISLIAALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRK 58 M SL +AV++ IG EN +PW+ P DL FK T+N +IMGR T+ S+ + LPGR Sbjct: 1 MASLNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRL 60 Query: 59 NIILS-SQPGTD--DRVTWVKSVDEAIAACG---DVPE---IMVIGGGRVYEQFLPKAQK 109 ++++S + P T D+V +V + A+ D PE I VIGG YE K Sbjct: 61 HVVVSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDK 120 Query: 110 LYLTHIDAEVEGDTHF 125 LYLT + + DT Sbjct: 121 LYLTRVQLNTQQDTEL 136 >UniRef50_C2CWT0 Dihydrofolate reductase n=1 Tax=Gardnerella vaginalis ATCC 14019 RepID=C2CWT0_GARVA Length = 210 Score = 81.3 bits (199), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 53/159 (33%), Positives = 79/159 (49%), Gaps = 24/159 (15%) Query: 14 IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKNIILSSQPG-TD 69 +G+ MPW L DL +FK T++ PVIMGR TW+S+ RPLPGR+NI++S P Sbjct: 24 MGVNGGMPWRLSTDLRYFKAMTISCPVIMGRGTWDSMPEKFRPLPGRENIVVSRNPDFNS 83 Query: 70 DRVTWVKSVDEAIAAC--------------GDVPE----IMVIGGGRVYEQFLPK--AQK 109 D S++EAI D+P+ + +IGGG ++ + + Sbjct: 84 DGAKSFTSIEEAICYAKKWIEDNPIEHVDSSDLPKDGSAVWIIGGGAIFREVIESQIVDA 143 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNS 148 Y+T ID VE DT P+ + + ++ D D Q S Sbjct: 144 AYVTQIDTRVEADTFAPNIQKLVDDGLWKVARDCDWQES 182 >UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilaginosa RepID=D2NRG7_9MICC Length = 222 Score = 80.5 bits (197), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/180 (32%), Positives = 81/180 (45%), Gaps = 43/180 (23%) Query: 13 VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKNIILS---SQP 66 +IG MPW P DLA FK+ TL PVIMGR TWES RPLPGR NI++S ++ Sbjct: 16 IIGRAGDMPWYAPEDLAHFKKVTLGAPVIMGRRTWESFPPRFRPLPGRTNIVISRSVTEA 75 Query: 67 GTDDRVTWVKSVDEAIAA----------------CGDVPEI--MVIGGGRVYEQFLPK-- 106 D WV S+D A+ A D P + +IGGG VY + L + Sbjct: 76 EERDGALWVPSLDAALYAARDAVGAPVEATPADTATDAPAVDAWIIGGGSVYAEALSRND 135 Query: 107 ----------AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 + L+ E+ GDT P+ + ++ H A S + C+ ++ Sbjct: 136 LPAFGRVKTVERTLFYCQEGNEITGDTRAPELQ-------LADSHGNCATGSPNGCWHVV 188 >UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae RepID=C0VZ67_9ACTO Length = 170 Score = 80.5 bits (197), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 52/151 (34%), Positives = 86/151 (56%), Gaps = 8/151 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR--PLPGRK 58 ++ +I A + +G + M W++PAD FK++T+ P+IMGR +W+++GR PLP R+ Sbjct: 3 VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRFAPLPQRR 62 Query: 59 NIILSSQPGTDDRVTWVK-SVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 NI+++ V S++EAI+ A D + + GG +YEQ +P A +L +T++D Sbjct: 63 NIVVTRNRDFIPEGGEVAFSIEEAISLASADSELVWIAGGAHIYEQAMPFADELVVTYLD 122 Query: 117 AEVEGD---THFPDYEPDDWESVFSEFHDAD 144 V + P +P WE V +E DAD Sbjct: 123 LNVSTAGPVVYAPQIDPAVWEVVKAE-SDAD 152 >UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RI81_TRIAD Length = 174 Score = 80.5 bits (197), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 56/185 (30%), Positives = 84/185 (45%), Gaps = 46/185 (24%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESI---GRPLPGR 57 + DR IG +N +PW L + +F R T + V+MGR+TW SI RPL R Sbjct: 1 MTRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNR 60 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIM----------------VIGGGRVYE 101 NI++SSQ ++ V E + +PE++ ++GG VY+ Sbjct: 61 INIVISSQLRAEE-------VPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYK 113 Query: 102 QFL--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADA------QNSHSYCF 153 F+ P+ ++YLT +DA E D FP+ D F E D D +N Y F Sbjct: 114 GFMSHPQCDRIYLTKLDANYECDVFFPEMSDD-----FKEISDPDVSQEVQEENGLKYTF 168 Query: 154 EILER 158 + +R Sbjct: 169 HVYQR 173 >UniRef50_Q6BTR6 DEHA2C16456p n=2 Tax=Debaryomyces hansenii RepID=Q6BTR6_DEBHA Length = 206 Score = 80.1 bits (196), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 59/155 (38%), Positives = 80/155 (51%), Gaps = 25/155 (16%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG---RP 53 ++AAL + IG++ MPW L ++ +FK T VIMGR TWESI RP Sbjct: 15 IVAALLPELGIGIKGKMPWRLRQEIKYFKNVTTTTKDPNGINAVIMGRKTWESIPTKFRP 74 Query: 54 LPGRKNIILS----SQPGTDDRVTWVKSVDEAIAACGD----VPEIMVIGGGRVYEQFLP 105 LPGR NI+LS S D+ + S++ A+A + V +I VIGG +Y + + Sbjct: 75 LPGRLNIVLSRSYVSHGSNDEDIILTNSIENALAKVEEYSKPVEKIFVIGGSELYNKLIS 134 Query: 106 --KAQKLYLTHIDAE--VEGDT--HFPDY-EPDDW 133 K Q L +T I + VE DT FP Y E DW Sbjct: 135 HEKVQHLLITEIKSTRPVEVDTWLKFPIYTESSDW 169 >UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SNM7_9FIRM Length = 166 Score = 79.3 bits (194), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 42/138 (30%), Positives = 73/138 (52%), Gaps = 5/138 (3%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIIL 62 ++A IG +N + + L D+ +FK T + +I GR T+E +PLP RKNI+L Sbjct: 9 IVAITEKTNAIGKDNNLLYFLKEDMNFFKEKTCDNSIICGRKTFEGFKIKPLPKRKNIVL 68 Query: 63 SSQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDAE-- 118 + + + V K++++ I + P + V GG +YEQ + ++Y+T + + Sbjct: 69 TKSDFSFEGVRRFKNIEDLINFVKENPKEKFFVCGGMSIYEQLIDFCSRMYITKYEEKEA 128 Query: 119 VEGDTHFPDYEPDDWESV 136 VE D+HFP + W+ V Sbjct: 129 VEADSHFPKIDEKVWKVV 146 >UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF Length = 193 Score = 79.3 bits (194), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 59/180 (32%), Positives = 93/180 (51%), Gaps = 30/180 (16%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-----------LNKPVIMGRHTWESI 50 ++ I A++ +R IG N +PW++P DL FK T L VIMGR T+ES+ Sbjct: 8 VAQIVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTAETDAYVDTGLKGIVIMGRKTFESM 67 Query: 51 G-RPLPGRKNIILSSQ---------PGTDDRVTWVKSVDEAIAACGDVPE------IMVI 94 G +PLP R N I+++Q G D V V ++D+A+ +V I VI Sbjct: 68 GSKPLPKRVNFIVTTQMDYAQQKGLEGLKD-VHVVHNLDDALTHAANVAHGLKFETIWVI 126 Query: 95 GGGRVYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCF 153 GG RV+++ + ++ LT +D ++E GD +P+ P+D+E D ++ SY F Sbjct: 127 GGERVFKRAMMFTDRIELTVVDTDIEDGDAFYPEI-PEDFELTQESESFTDEKSGLSYKF 185 >UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EC32 Length = 190 Score = 79.3 bits (194), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 57/181 (31%), Positives = 82/181 (45%), Gaps = 28/181 (15%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 +LIAA+ + IG + +PWNL +L +F R T + VIMGR TW+S+ Sbjct: 5 FNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHNW 64 Query: 52 RPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLP 105 +PLPGR N +L++Q D +++ I + VIGG +VYE L Sbjct: 65 KPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVYESVLK 124 Query: 106 K--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD------ADAQNSHSYCFEILE 157 + YLT I E E D F +Y D+ F E D +N Y F + E Sbjct: 125 YGLCHRFYLTRIKKEFECDCFF-NY---DFTKDFKEVSDDRVPKGVQKENEIEYVFHVYE 180 Query: 158 R 158 + Sbjct: 181 K 181 >UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK Length = 234 Score = 79.3 bits (194), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/161 (34%), Positives = 74/161 (45%), Gaps = 25/161 (15%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I +I A D VIG MPW LP DL FK T PV+MGR +WE++ RPLP R Sbjct: 42 IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDDGFRPLPDRT 101 Query: 59 NIILSSQPGTDDRVTWVK--------------------SVDEAIAACGDVPEIMVIGGGR 98 N +++ Q D V+ S D+ A P + V+GGG+ Sbjct: 102 NYVITRQDNYDAPGGIVEPSIPSALANAAEQILNELTDSADKGEGADDRTPTVWVLGGGQ 161 Query: 99 VYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSE 139 VY Q +P A ++ +T ID +E F Y P E F E Sbjct: 162 VYAQCMPVADRIVITEID--MEAPERFQVYAPLVPEEEFEE 200 >UniRef50_C3JYD2 Putative dihydrofolate reductase n=1 Tax=Pseudomonas fluorescens SBW25 RepID=C3JYD2_PSEFS Length = 165 Score = 79.3 bits (194), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 46/126 (36%), Positives = 70/126 (55%), Gaps = 7/126 (5%) Query: 11 DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNIILSSQP 66 +R IG + +P D+ F T+ KPVIMGR T+ES+ GRPL R NI+LS P Sbjct: 8 NRSIGKAGGLLRMVPDDMRRFAAKTIGKPVIMGRKTFESVIALSGRPLADRPNIVLSRNP 67 Query: 67 GTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGG-RVYEQFLPKAQKLYLTHIDAEVEGDT 123 + ++ +S+ A+ PE + IGGG +Y+Q + + +LYLT + + EG+ Sbjct: 68 AFEHEQAVVCRSLASALECAASYHPEEIHIGGGPELYDQVIDRVDRLYLTLFNDDHEGEA 127 Query: 124 HFPDYE 129 FP +E Sbjct: 128 RFPSFE 133 >UniRef50_D0WS26 Dihydrofolate reductase n=1 Tax=Actinomyces sp. oral taxon 848 str. F0332 RepID=D0WS26_9ACTO Length = 184 Score = 79.0 bits (193), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 56/138 (40%), Positives = 75/138 (54%), Gaps = 4/138 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 ++ I A +R IG + A+PW LP DLA F+R T PVIMGR TWES+ RPLPGR Sbjct: 2 ILGAIWAQGRERAIGKDGALPWRLPEDLALFRRVTSGHPVIMGRKTWESLPPRFRPLPGR 61 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS P D V+S+ EA A + +IGG +Y + + A L +T +D Sbjct: 62 RNIVLSRDPSFAADGAEAVRSLAEAAEAASHCEQAWIIGGAALYAEAVNVADVLVVTDVD 121 Query: 117 AEVEGDTHFPDYEPDDWE 134 +VEG F W Sbjct: 122 VDVEGADAFAPSIGGSWR 139 >UniRef50_B9YC91 Putative uncharacterized protein n=1 Tax=Holdemania filiformis DSM 12042 RepID=B9YC91_9FIRM Length = 157 Score = 79.0 bits (193), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 52/135 (38%), Positives = 78/135 (57%), Gaps = 4/135 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I++IAAL +G MPW+ PADL F+ T+ KP++MGR T E + R L GR+ II Sbjct: 3 ITMIAALDEVGGLGKAGRMPWHCPADLRQFQAYTMGKPLLMGRKTAEPLRRRLLGRQLII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 S+ D V++V+EA+A P E+++ GGG +Y +LP A L ++ I Sbjct: 63 -QSRTMKDPDFPVVRTVNEALAWMAARPEFDELVIGGGGEIYALWLPYAAHLRISRIAGR 121 Query: 119 VEGDTHFPDYEPDDW 133 + DT FP ++P +W Sbjct: 122 FDCDTFFPKWDPQEW 136 >UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis 101-4-CHN RepID=C7XU42_9LACO Length = 166 Score = 78.6 bits (192), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 41/125 (32%), Positives = 64/125 (51%), Gaps = 4/125 (3%) Query: 14 IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVT 73 IG +PW+LP DL FK T + P++MG T+ SIGRPLP R NI++S P D+V Sbjct: 15 IGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIVVSHHPVAVDQVI 74 Query: 74 WVKSVDEAIAAC----GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYE 129 V ++++ + D E+ +IGG ++ Q + L+ T + GD + Sbjct: 75 TVTNIEDLMNLIFKRYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMGNHHGDVKMIPID 134 Query: 130 PDDWE 134 W+ Sbjct: 135 YHQWQ 139 >UniRef50_Q96V60 Dihydrofolate reductase (Fragment) n=2 Tax=Pneumocystis carinii RepID=Q96V60_PNECA Length = 176 Score = 78.6 bits (192), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 53/149 (35%), Positives = 78/149 (52%), Gaps = 26/149 (17%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP----------VIMGRHTWESI--- 50 LI AL V IG NA+PW L +D+A+FKR T + P V+MGR TWES+ Sbjct: 1 LIVALTVSCGIGKGNALPWRLKSDMAYFKRVTSDVPVSDSTKWMNVVLMGRKTWESLPER 60 Query: 51 GRPLPGRKNIILSSQPGTD--DRVTWVKSVDEAI---------AACGDVPEIMVIGGGRV 99 RPL GR N+++S Q D KS+++A+ ++ V I VIGG ++ Sbjct: 61 FRPLKGRINVVISRQEVLDLGQGTYHAKSLNDALVLLSCIYDTSSSIQVNRIFVIGGAQL 120 Query: 100 YEQFL--PKAQKLYLTHIDAEVEGDTHFP 126 Y+ + P+ ++ T I E++ D FP Sbjct: 121 YKAAMEHPRLDRIMATVIHKEIDCDVFFP 149 >UniRef50_C4G1L6 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G1L6_ABIDE Length = 165 Score = 78.2 bits (191), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/156 (33%), Positives = 81/156 (51%), Gaps = 13/156 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I LIAA+ + IG + ++ + +P DL FK+ T V+MGR T+ESIG PL R NI Sbjct: 3 IKLIAAVDLRFGIGKDGSLLFKIPEDLRLFKQLTTGNIVLMGRKTFESIGCIPLTDRINI 62 Query: 61 ILSSQPGTDDR-VTWVKSVDEAIAACGDV---PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++SS ++ V + AI C + ++ +IGGG++YEQ + A ++ LT + Sbjct: 63 VISSAKKYENEDVINFDNYKTAIEYCKQIFSDKDLYIIGGGKIYEQGIKYADEIILTKYN 122 Query: 117 AEVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSY 151 E DT+FP + F +AD SY Sbjct: 123 KVYEDVDTYFP-------VDIMDNFSEADVIMEGSY 151 >UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella multocida RepID=Q6A328_PASMU Length = 169 Score = 78.2 bits (191), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 51/161 (31%), Positives = 77/161 (47%), Gaps = 10/161 (6%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRPLPGRKN 59 SLI A+ R +G +N + W+LP D+ +FK T V+MGR +WESI RPLP R N Sbjct: 6 SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPQKYRPLPNRLN 65 Query: 60 IILSSQPG-TDDRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKA--QKLYLTHI 115 +L+ + + T + + E G +IGG ++Y+ L ++Y+T + Sbjct: 66 FVLTRDKNYSAEGATVIYDLKEVAQHLEGKNLTCFIIGGAQIYQLALETGLLNEMYVTQV 125 Query: 116 DAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155 E DT FP +WE + + D H Y F I Sbjct: 126 HNTFEEADTFFPFVNWGEWEE--EDILEQDKDEKHLYSFNI 164 >UniRef50_Q937I9 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q937I9_ECOLX Length = 189 Score = 77.8 bits (190), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 46/142 (32%), Positives = 83/142 (58%), Gaps = 5/142 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI+A + + VIG +PW+ + FK T N+ +++GR T++S+G LP RK + Sbjct: 3 ISLISATSENGVIGNGPDLPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61 Query: 62 LSSQ--PGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S + +++ V S++ A+ + + + V GGG++Y + KA ++L+ + E Sbjct: 62 VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEF 140 VEGD +FP P+++ VF +F Sbjct: 122 VEGDINFPKI-PENFNLVFEQF 142 >UniRef50_Q0FG98 Dihydrofolate reductase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FG98_9RHOB Length = 159 Score = 77.8 bits (190), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 44/132 (33%), Positives = 72/132 (54%), Gaps = 6/132 (4%) Query: 1 MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRK 58 MI I A + IG +PW + PADL WFK NTLN ++MG+ TW+S+ R PLP R+ Sbjct: 1 MIKAILACDDEWGIGKNGDLPWPHNPADLRWFKNNTLNSVIVMGKSTWDSLPRKPLPNRE 60 Query: 59 NIILSSQP---GTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 N+I+++ G DD ++ +++ D+ I +IGG ++ + ++ +L+ Sbjct: 61 NLIVTTSKQEFGYDDYEFINFSDLEVKLSSTKDINNIWIIGGAKLISGLINFIEEFHLSR 120 Query: 115 IDAEVEGDTHFP 126 I+ DT P Sbjct: 121 INGNFNCDTFLP 132 >UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX Length = 157 Score = 77.4 bits (189), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/160 (30%), Positives = 92/160 (57%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI+A + + VIG +PW+ + FK T N+ +++GR T++S+G LP RK + Sbjct: 3 ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61 Query: 62 LSSQ--PGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S + +++ V S++ A+ + + + V GGG++Y + KA ++L+ + E Sbjct: 62 VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGD +FP P+++ VF +F ++ +Y ++I ++ Sbjct: 122 VEGDINFPKI-PENFNLVFEQFFLSNI----NYTYQIWKK 156 >UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRL8_9FIRM Length = 161 Score = 77.4 bits (189), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/138 (34%), Positives = 73/138 (52%), Gaps = 5/138 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 + +I A+ + IG + + +L DL K T+ ++MG T+ S RPLP R+N+ Sbjct: 1 MEIIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPKRPLPDRENL 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 I++ P + VDE + + D P I V+GGG VYEQ LP +K ++T I Sbjct: 61 IITHHPENYPGIKCFTGVDEFLEYSKTADKP-IFVLGGGSVYEQLLPYCEKAHITKILHS 119 Query: 119 VEGDTHFPDYEPD-DWES 135 E DT FP+ + + DWE Sbjct: 120 FEADTFFPNLDNNPDWEK 137 >UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis RepID=DYR_PNECA Length = 206 Score = 77.4 bits (189), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/173 (30%), Positives = 86/173 (49%), Gaps = 27/173 (15%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP----------VIMGRHTWESI- 50 ++LI AL IG N++PW L ++++FKR T P V+MGR TWESI Sbjct: 7 LTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIP 66 Query: 51 --GRPLPGRKNIILSSQPGTD--DRVTWVKSVDEAI---------AACGDVPEIMVIGGG 97 RPL GR N++++ D + + KS+D A+ + + I VIGG Sbjct: 67 LQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGA 126 Query: 98 RVYEQFL--PKAQKLYLTHIDAEVEGDTHFP-DYEPDDWESVFSEFHDADAQN 147 ++Y+ + PK ++ T I ++ D FP + +W SV+ + +D ++ Sbjct: 127 QLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLES 179 >UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3 Length = 163 Score = 76.6 bits (187), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 46/139 (33%), Positives = 75/139 (53%), Gaps = 6/139 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPGRKN 59 ++LIAA+ + IG N + +P D +F+ T K V+MGR T ES RPL R N Sbjct: 1 MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPNSRPLKNRTN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ P + + V S+DE + +I +IGG ++YEQ + + ++T +D Sbjct: 61 IVLTHNPSYEVEGAVVVHSLDELHKELEKYNSEDIYIIGGQKIYEQLVDECDVAHITKVD 120 Query: 117 AEVEGDTHFPDY-EPDDWE 134 E + D +FP+ E +W+ Sbjct: 121 FEYDADAYFPNLDEKPEWQ 139 >UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE Length = 462 Score = 76.6 bits (187), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 45/153 (29%), Positives = 79/153 (51%), Gaps = 11/153 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 S++ A+ ++ IG +N +PW L DL FK+ T VIMGR T+ES+ +PLP R N+ Sbjct: 7 FSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPLPNRVNV 66 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLP--KAQKLYLTHIDA 117 ++S + + V +++A+ ++ +IGG R++E+ L K ++LT I Sbjct: 67 VISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVHLTRIGV 126 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHS 150 E + D + +++FS F + S Sbjct: 127 ETKCDVYLN-------KNIFSTFQVNKTSQTKS 152 >UniRef50_C2KQT3 Possible dihydrofolate reductase n=2 Tax=Mobiluncus mulieris RepID=C2KQT3_9ACTO Length = 227 Score = 75.9 bits (185), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 48/146 (32%), Positives = 75/146 (51%), Gaps = 13/146 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +I A VIG M W +P DL +FK T+ PVIMG +++++G PL GR+NII Sbjct: 55 LGVIWAEDCHHVIGAGGGMVWRVPDDLRFFKETTMGCPVIMGTGSFKALGEPLKGRRNII 114 Query: 62 LSSQPGT------DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPK--AQKLYLT 113 L+ P + + ++D+AI C E+ + GGG VY++ + A L ++ Sbjct: 115 LTRHPSALADFTREGLIETASNLDDAIKLCAGTKEVWITGGGVVYQEVMDAGIADLLVVS 174 Query: 114 HID--AEVEGD---THFPDYEPDDWE 134 +D A V D T P +P W+ Sbjct: 175 QLDLIAPVPPDAKVTVAPVIDPQRWQ 200 >UniRef50_C4LHD2 Bifunctional dihydrofolate reductase-thymidylate synthase n=1 Tax=Corynebacterium kroppenstedtii DSM 44385 RepID=C4LHD2_CORK4 Length = 221 Score = 75.5 bits (184), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/140 (42%), Positives = 72/140 (51%), Gaps = 24/140 (17%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR---PLPGR 57 +I +I A D VIG MPW++P D+A FK+ T PVIMG TW SI PLPGR Sbjct: 31 LIGVIWASDRDGVIGDGTRMPWHVPEDMAHFKQLTWGVPVIMGSATWSSIPSRFTPLPGR 90 Query: 58 KNIILS---SQPGTDDRVTWVKSVDEAIAACGDVP-------------EIMVIGGGRVYE 101 NI+LS S T D V S+D AA D+P + VIGGG VY Sbjct: 91 TNIVLSRRWSDEDTPDGVILHHSLD---AAFKDIPHPVFTRRVAPENVDAWVIGGGEVYR 147 Query: 102 QFL--PKAQKLYLTHIDAEV 119 + L P+ + LT IDA V Sbjct: 148 EALTRPEVRLAVLTEIDAAV 167 >UniRef50_P0ABQ7 Dihydrofolate reductase type 8 n=2 Tax=Enterobacteriaceae RepID=DYR8_ECOLX Length = 169 Score = 75.1 bits (183), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 58/157 (36%), Positives = 82/157 (52%), Gaps = 17/157 (10%) Query: 1 MISLIAALAV--DRVIGMENAMPWN-LPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57 MI L A LA + IG +NA+PW L DLA FK+ T+ K VIMGR T+ES+ L GR Sbjct: 1 MIELHAILAATANGCIGKDNALPWPPLKGDLARFKKLTMGKVVIMGRKTYESLPVKLEGR 60 Query: 58 KNIILSSQ----PGTDDR--VTWVKSVDEAI-----AACGDVPEIMVIGGGRVYEQFLPK 106 I+++ Q PG D +V +V +A+ + GDV VIGG ++++ Sbjct: 61 TCIVMTRQALELPGVRDANGAIFVNNVSDAMRFAQEESVGDVA--YVIGGAEIFKRLALM 118 Query: 107 AQKLYLTHIDAEVEGDTHFPDYE-PDDWESVFSEFHD 142 ++ LT + EGDT+ E D+E E HD Sbjct: 119 ITQIELTFVKRLYEGDTYVDLAEMVKDYEQNGMEEHD 155 >UniRef50_Q8SDF8 PHIKZ004 n=1 Tax=Pseudomonas phage phiKZ RepID=Q8SDF8_9CAUD Length = 173 Score = 74.7 bits (182), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 48/156 (30%), Positives = 85/156 (54%), Gaps = 20/156 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I LI A ++ VIG N +PW++P DLA+FK T VIMG++T+ S+G +PLP R NI Sbjct: 3 IKLIVAHDLNGVIGYNNLLPWHIPEDLAFFKEMTTGCCVIMGKNTFLSLGSKPLPNRNNI 62 Query: 61 ILSSQ--------PGTDDRVTWVKSVDEAIAACGDV-----PEIMVIGGGRVYEQFLPK- 106 ++SS D+++ + ++ AI ++ +IGG ++Y++ + K Sbjct: 63 VVSSSLYRNGNYPVAYDNKLGVLPNLSAAIVYATHFNKETGKDVWIIGGSQLYKEVIEKD 122 Query: 107 -AQKLYLTHIDAEVEGDT--HFPD--YEPDDWESVF 137 ++Y+T + E++ + +FP + D W+S Sbjct: 123 ILDEMYITTVKMEIDNSSCVYFPKEIIKWDKWKSTI 158 >UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cellular organisms RepID=B6AE97_9CRYT Length = 549 Score = 74.3 bits (181), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 49/156 (31%), Positives = 82/156 (52%), Gaps = 29/156 (18%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-----------------KPVIMG 43 +I ++AA ++ IG N +PW++ DL +F+ T + +I+G Sbjct: 22 VIIIVAASTKEKGIGKGNNLPWSIKEDLKFFREITCSTIEQSQDDKENTKIEKVNAIILG 81 Query: 44 RHTWESIGR-PLPGRKNIILS-----SQPGTDDRVTWVKSVDEAIAACGD---VPEIMVI 94 R TW+S+ R PL RK I+LS D V+ VKS+DEAI C + + +I++ Sbjct: 82 RKTWDSMKRIPLKNRKVIVLSRTLQRCDNKNDSGVSIVKSLDEAINLCNNDISIHKIVIC 141 Query: 95 GGGRVYEQFLPK--AQKLYLTHID-AEVEGDTHFPD 127 GG +Y + + K + +YLT + ++ E DT+FP+ Sbjct: 142 GGESIYRECIEKNIVETIYLTRVSTSKKEFDTYFPN 177 >UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE Length = 187 Score = 74.3 bits (181), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 23/156 (14%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51 S I A+ + R IG N +PW + D+ +F T VIMGR WESI Sbjct: 8 FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67 Query: 52 RPLPGRKNIILS---SQPGTDDRVTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQ 102 RPL GR NI+LS S+P ++ +S ++A+ P + V GG +Y+ Sbjct: 68 RPLKGRLNIVLSRTLSEPPQGAQL--CRSFEQALTILSTDPYTKKIENVFVCGGSALYKD 125 Query: 103 FLPKA--QKLYLTHIDAEVEGDTHFPDYEPDDWESV 136 + + ++Y+T+ID E + D FP+++ + + V Sbjct: 126 AMAHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLV 161 >UniRef50_Q5V3R2 Dihydrofolate reductase 1 n=1 Tax=Haloarcula marismortui RepID=DYR1_HALMA Length = 185 Score = 74.3 bits (181), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 50/170 (29%), Positives = 78/170 (45%), Gaps = 38/170 (22%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+ A + VIG++ +PW+ P D+ +K P+I+GR T+ES+ +P+P ++ Sbjct: 9 LVLVVAADENNVIGLDGGVPWHYPEDVRQYKNRIAGHPIILGRRTFESM-KPIPDCYTVV 67 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEI----------------------------MV 93 L+S DDR +S D P+I V Sbjct: 68 LTS----DDR----RSADSETVEYATTPQIAVEAAARAGASGAFAGDSAGADSSPPVTYV 119 Query: 94 IGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA 143 IGG VY+ FLP A +++L+ I EGD +FPD +W + E HD Sbjct: 120 IGGEAVYDLFLPFAGRVFLSRIHEHNEGDRYFPDLGA-EWTELSREPHDG 168 >UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH Length = 167 Score = 73.6 bits (179), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 52/149 (34%), Positives = 77/149 (51%), Gaps = 12/149 (8%) Query: 6 AALAVDRV--IGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI--GRPLPGRKNII 61 A +AVD IG + + +P D+ +F++ TLNK V+MGR T+ES+ PL R NII Sbjct: 3 AIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPGKEPLKDRVNII 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS + D + +SVD + +I VIGG VY Q LP + ++T + Sbjct: 63 LSKSENIEKDGIIICRSVDGLFLELKKYNSDDIFVIGGEEVYTQLLPYCSEAHVTKFNGA 122 Query: 119 VEGDTHFPDY-EPDDWESVF----SEFHD 142 D +FP+ E + W+ V EF+D Sbjct: 123 YSADRYFPNLDEMEGWKLVCVGEPKEFND 151 >UniRef50_C0VSW2 Dihydrofolate reductase n=2 Tax=Corynebacterium glucuronolyticum RepID=C0VSW2_9CORY Length = 167 Score = 73.6 bits (179), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 41/110 (37%), Positives = 62/110 (56%), Gaps = 6/110 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILS 63 I A + D +IG + MPW LP DL FK T+ + ++MGR TWESIG + LPGR N++LS Sbjct: 4 IWAQSRDGIIGDGSTMPWYLPEDLHHFKNTTMGEDILMGRKTWESIGSKALPGRTNLVLS 63 Query: 64 SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 ++ D W + D + +IGGG +Y+ P+ ++ +T Sbjct: 64 TREPGD----WSAGATVVSSVPADF-DGWLIGGGSLYQSLYPRLSRIAVT 108 >UniRef50_Q6F181 Dihydrofolate reductase n=1 Tax=Mesoplasma florum RepID=Q6F181_MESFL Length = 161 Score = 73.2 bits (178), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 38/144 (26%), Positives = 75/144 (52%), Gaps = 8/144 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI +I A VIG +N++PW++ ++ F+ TLN+ V+MG T+ES+ + LP R N Sbjct: 1 MIKMIWAQTEKGVIGKDNSLPWSIKEEMQHFRTTTLNQNVLMGGKTFESMNFKGLPNRIN 60 Query: 60 IILSS-----QPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYL 112 +L+ + + V ++ D + ++ +IGG ++YE F ++ Sbjct: 61 YVLTRDTEKYKEHMSENVNFINKKDFILKEFKGNTSKDVYIIGGSQIYELFFDDCDEIIR 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESV 136 + I + EG+ H ++ D+++ + Sbjct: 121 SMIKDDFEGNVHIKNFNYDNFDKI 144 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteria... 269 2e-71 UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobact... 261 5e-69 UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepI... 250 1e-65 UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2 242 2e-63 UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteoba... 242 3e-63 UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05... 239 2e-62 UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistip... 239 2e-62 UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD 237 1e-61 UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria R... 236 2e-61 UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacte... 235 4e-61 UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D... 234 5e-61 UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacte... 234 8e-61 UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria ... 231 6e-60 UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacte... 230 1e-59 UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burneti... 230 1e-59 UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=... 229 2e-59 UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobact... 229 2e-59 UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD 229 2e-59 UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales ... 229 2e-59 UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium... 227 1e-58 UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacte... 227 1e-58 UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacter... 226 2e-58 UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium j... 224 8e-58 UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pin... 223 2e-57 UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6 223 2e-57 UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria ... 222 3e-57 UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lit... 221 5e-57 UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacill... 221 5e-57 UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobact... 221 5e-57 UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus rube... 221 8e-57 UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria R... 220 1e-56 UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria ... 219 2e-56 UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes R... 219 2e-56 UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium ... 219 3e-56 UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales... 219 4e-56 UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter no... 218 4e-56 UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved... 218 4e-56 UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q... 217 6e-56 UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accum... 217 8e-56 UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobact... 217 8e-56 UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp... 217 1e-55 UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=... 217 1e-55 UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succ... 217 1e-55 UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobia... 216 2e-55 UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=... 216 2e-55 UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri... 216 2e-55 UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorifti... 215 3e-55 UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter Rep... 215 4e-55 UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A... 214 5e-55 UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanth... 214 6e-55 UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobact... 214 7e-55 UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methyloph... 214 8e-55 UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus Re... 214 8e-55 UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesic... 214 9e-55 UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q... 214 9e-55 UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae ... 214 9e-55 UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella ... 214 1e-54 UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria ... 213 2e-54 UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q... 212 2e-54 UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax parad... 212 3e-54 UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q... 212 3e-54 UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteob... 212 4e-54 UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepI... 211 5e-54 UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchi... 211 6e-54 UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=D... 210 1e-53 UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae R... 210 1e-53 UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staley... 210 1e-53 UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organi... 210 2e-53 UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica... 209 2e-53 UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C... 209 2e-53 UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp.... 209 2e-53 UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni ... 208 4e-53 UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae ... 208 4e-53 UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales Re... 208 4e-53 UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter... 208 5e-53 UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonel... 207 1e-52 UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonel... 205 3e-52 UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candida... 205 3e-52 UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiace... 205 3e-52 UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadacea... 205 4e-52 UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria R... 205 4e-52 UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris ... 205 5e-52 UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm... 204 5e-52 UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm... 204 6e-52 UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus Re... 204 6e-52 UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales R... 204 1e-51 UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobi... 203 1e-51 UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas su... 203 2e-51 UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella Rep... 202 2e-51 UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. ... 202 2e-51 UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organis... 202 3e-51 UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mult... 202 3e-51 UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium Rep... 201 6e-51 UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 201 6e-51 UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 200 1e-50 UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobac... 199 2e-50 UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus ... 199 4e-50 UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=D... 198 4e-50 UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepI... 198 4e-50 UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicade... 198 5e-50 UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomi... 197 7e-50 UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus R... 197 7e-50 UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q... 197 7e-50 UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 197 1e-49 UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus Re... 195 3e-49 UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales... 195 4e-49 UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus Re... 195 4e-49 UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroco... 195 5e-49 UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepI... 195 5e-49 UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepI... 194 6e-49 UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azoba... 194 6e-49 UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio ac... 194 8e-49 UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. ... 194 1e-48 UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacte... 194 1e-48 UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gam... 193 1e-48 UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepI... 193 2e-48 UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus Re... 192 4e-48 UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate... 192 4e-48 UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus ... 192 5e-48 UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococ... 191 5e-48 UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula mar... 191 6e-48 UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri... 190 9e-48 UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales ... 190 1e-47 UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter... 190 1e-47 UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidat... 190 1e-47 UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID... 190 2e-47 UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas ue... 190 2e-47 UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae... 189 2e-47 UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus R... 189 2e-47 UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacte... 189 2e-47 UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia ... 189 3e-47 UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin5... 189 4e-47 UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp.... 188 4e-47 UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales ... 188 7e-47 UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus R... 187 8e-47 UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perf... 187 1e-46 UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas... 186 2e-46 UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berge... 186 2e-46 UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus Re... 185 3e-46 UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate red... 185 4e-46 UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolys... 185 5e-46 UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus Re... 184 9e-46 UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=... 184 9e-46 UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae... 184 1e-45 UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales ... 184 1e-45 UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula b... 184 1e-45 UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium v... 184 1e-45 UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatu... 183 2e-45 UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus Re... 183 2e-45 UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae R... 183 2e-45 UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C... 182 3e-45 UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopisc... 182 3e-45 UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perf... 182 3e-45 UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Ba... 182 4e-45 UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidic... 182 5e-45 UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium ... 181 5e-45 UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuring... 180 9e-45 UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mult... 180 1e-44 UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muci... 180 1e-44 UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepI... 180 1e-44 UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cell... 180 1e-44 UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales... 180 2e-44 UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID... 179 3e-44 UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organis... 179 4e-44 UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacter... 179 4e-44 UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebac... 178 6e-44 UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fae... 177 9e-44 UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xen... 177 1e-43 UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter form... 176 2e-43 UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deutero... 176 2e-43 UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase ... 176 2e-43 UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (... 176 2e-43 UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium ... 176 2e-43 UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Cl... 176 2e-43 UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis... 176 3e-43 UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloac... 175 3e-43 UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus fa... 175 3e-43 UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena tu... 175 3e-43 UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis viresc... 175 4e-43 UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stella... 175 5e-43 UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacte... 174 7e-43 UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales... 174 7e-43 UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobact... 174 1e-42 UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae Re... 174 1e-42 UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira h... 174 1e-42 UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepI... 173 2e-42 UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbi... 172 3e-42 UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saph... 172 4e-42 UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=... 171 5e-42 UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi... 171 7e-42 UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacte... 171 7e-42 UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcacea... 171 7e-42 UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacte... 171 8e-42 UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniob... 170 9e-42 UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cav... 169 4e-41 UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin... 168 4e-41 UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacteriu... 168 5e-41 UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax... 168 6e-41 UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus R... 167 7e-41 UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus co... 167 9e-41 UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum ... 167 1e-40 UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrif... 167 1e-40 UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix r... 167 1e-40 UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadacea... 167 1e-40 UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea vi... 167 2e-40 UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota R... 166 2e-40 UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichop... 166 2e-40 UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobact... 165 6e-40 UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatu... 165 6e-40 UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostri... 165 6e-40 UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reduc... 165 6e-40 UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypotheti... 165 6e-40 UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium ... 164 9e-40 UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mans... 164 1e-39 UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocace... 164 1e-39 UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinom... 163 2e-39 UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lito... 163 2e-39 UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorh... 162 3e-39 UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococ... 162 4e-39 UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptoba... 161 5e-39 UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmone... 161 5e-39 UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaeroc... 161 6e-39 UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346... 161 8e-39 UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus... 160 9e-39 UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX6... 160 1e-38 UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae... 159 2e-38 UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepI... 159 3e-38 UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria... 158 4e-38 UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphoki... 158 4e-38 UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID... 158 4e-38 UniRef50_A8RBH0 Putative uncharacterized protein n=1 Tax=Eubacte... 158 5e-38 UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phyto... 158 6e-38 UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marin... 158 6e-38 UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=... 158 6e-38 UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure... 157 8e-38 UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root R... 157 1e-37 UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella parame... 157 1e-37 UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales ... 157 1e-37 UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_... 157 1e-37 UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim res... 157 1e-37 UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus Re... 156 2e-37 UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q... 156 2e-37 UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentispha... 156 3e-37 UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=... 155 3e-37 UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis Re... 154 7e-37 UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherich... 154 8e-37 UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilagin... 153 2e-36 UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteri... 153 2e-36 UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria... 153 2e-36 UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium ... 152 2e-36 Sequences not found previously or not previously below threshold: >UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteriaceae RepID=DYR_ECOL6 Length = 159 Score = 269 bits (690), Expect = 2e-71, Method: Composition-based stats. Identities = 159/159 (100%), Positives = 159/159 (100%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI Sbjct: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE Sbjct: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 >UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobacteria RepID=DYR_KLEAE Length = 159 Score = 261 bits (668), Expect = 5e-69, Method: Composition-based stats. Identities = 142/159 (89%), Positives = 152/159 (95%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAAL VDRVIGMENAMPWNL DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI Sbjct: 1 MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE Sbjct: 61 VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159 >UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU Length = 168 Score = 250 bits (639), Expect = 1e-65, Method: Composition-based stats. Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A+ +R+IG +N +PW+LP DLA+FK+ T +IMGR T+ESIGRPLP RKNI Sbjct: 1 MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++S P ++ T V S+ + + C E VIGG ++Y P A +LY+T I E Sbjct: 61 VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD HFP+++ +W+ V SE D +N + Y F + E++ Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160 >UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2 Length = 161 Score = 242 bits (619), Expect = 2e-63, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 91/160 (56%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A+ +R+IG +N +PW+LP DLA+FK+ T ++MGR T+ESIGRPLP R+NI Sbjct: 1 MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNI 60 Query: 61 IL-SSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++ S + S +E + E VIGG ++Y P A +LY+T I Sbjct: 61 VVTSRDESSFPGCITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKIHHVF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP++ +WE + D +N + Y + + E++ Sbjct: 121 EGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK 160 >UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria RepID=DYR3_SALTY Length = 162 Score = 242 bits (619), Expect = 3e-63, Method: Composition-based stats. Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAALA + +IG +N +PW+LPADL FK TL KPV+MGR T+ESIGRPLPGR+N+ Sbjct: 2 LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S P + V S+D A+A D E M+IGGG++Y + LP+A +LYLT+IDA++ Sbjct: 62 VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDY W+ + H AD +NS++ F L R+ Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161 >UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium RepID=D0U4K0_9GAMM Length = 179 Score = 239 bits (612), Expect = 2e-62, Method: Composition-based stats. Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ +++IG NA+PW+LPADL +FK+ T K V+MGR T+ESIGRPLP R+N+I Sbjct: 21 LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S+D A+ D E+MV+GG YEQ LP +LY+T I+ E + Sbjct: 81 VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD HFP ++ + V E H AD +N ++Y F IL+R Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178 >UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MUX5_9BACT Length = 160 Score = 239 bits (611), Expect = 2e-62, Method: Composition-based stats. Identities = 62/159 (38%), Positives = 97/159 (61%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++I A+A + VIG +N + W++ DL FK T PV+MGR T+ES+GRPLPGR+N+ Sbjct: 1 MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNV 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +++ Q + + V S+DEA+A ++ VIGG ++Y Q LP + YLT + + Sbjct: 61 VVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQ 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP ++ +WE + SE + + + + FE RR Sbjct: 121 GDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR 159 >UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD Length = 162 Score = 237 bits (605), Expect = 1e-61, Method: Composition-based stats. Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAA+ +R+IG +N +PW+LP DL +FK T VIMGR T+ESIGRPLP R+NI Sbjct: 1 MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 I++S D + S +EA+ + E VIGG +Y + LP A KLY+T ID Sbjct: 61 IVTSNKELDIPNCQVMHSAEEAVRFAKNRNEECFVIGGSTLYTEILPFADKLYVTKIDET 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD +FP++ +WE V D +N + Y F + +R+ Sbjct: 121 FEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK 161 >UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME Length = 166 Score = 236 bits (602), Expect = 2e-61, Method: Composition-based stats. Identities = 66/159 (41%), Positives = 93/159 (58%), Gaps = 2/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +++LI A A + VIG N +PW LP DL FKR T+ P+IMGR TW+SIGRPLPGR+NI Sbjct: 3 LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ + V S+++A C ++ +IGG ++Y + LP A +L +T IDA+V Sbjct: 63 VVTRNRDLHIEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADV 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP + W E H + N Y F ER Sbjct: 123 EGDAFFPAVDRTTWVETARELHHS-ETNGFDYAFVTYER 160 >UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacteria RepID=A1U3D7_MARAV Length = 171 Score = 235 bits (600), Expect = 4e-61, Method: Composition-based stats. Identities = 69/164 (42%), Positives = 100/164 (60%), Gaps = 8/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 +LI A+A +RVIG N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++ Sbjct: 4 ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63 Query: 63 SSQP--GTDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 S P S++EA+ A E+M+IGGG++Y + LP ++Y+T Sbjct: 64 SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGDEVMIIGGGQIYAEALPMVDRIYITQ 123 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + AEV+GD FP+ D+WE + E A N + Y F + +R Sbjct: 124 VHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167 >UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI Length = 163 Score = 234 bits (599), Expect = 5e-61, Method: Composition-based stats. Identities = 71/160 (44%), Positives = 104/160 (65%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+ Sbjct: 3 ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ + VT V ++D+AIA + EI VIGG +Y+ LP A LYLT I + Sbjct: 63 LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD +FP+++ ++W+ V H AD +++ S+ F E+ Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162 >UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=D0KZ69_HALNC Length = 177 Score = 234 bits (598), Expect = 8e-61, Method: Composition-based stats. Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+AAL ++VIG NA+PW+LPADL FK+ T+ KP+IMGR T++SIGRPLPGRKNI+ Sbjct: 3 IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 +S P D VT V S+D A+ A PE+MVIGG +Y QFLP+A +LY T + + Sbjct: 63 ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD FP Y DW V E H ADA N Y F +R Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161 >UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY Length = 176 Score = 231 bits (590), Expect = 6e-60, Method: Composition-based stats. Identities = 79/165 (47%), Positives = 103/165 (62%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAALA +RVIG +N +PW+LPADL FK TL KP+IMGR TW+S+GRPLPGR NI+ Sbjct: 11 LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S Q G T + +++EAI D E+M+IGG ++YE L +A +LYLT Sbjct: 71 VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + E EGD FP + W S H A A+ Y FE+ ERR Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174 >UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacteria RepID=Q3JEI1_NITOC Length = 165 Score = 230 bits (587), Expect = 1e-59, Method: Composition-based stats. Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS I A+ + +IG +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI Sbjct: 2 IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ P T V +V+ + A G+ E+ VIGG +YEQ LP+A+++YLT + Sbjct: 62 VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GDT FP ++P W V+ E +D D QN + Y F LER Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160 >UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii RepID=A9KH09_COXBN Length = 161 Score = 230 bits (587), Expect = 1e-59, Method: Composition-based stats. Identities = 67/159 (42%), Positives = 106/159 (66%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +I+LIAA+ +R+IG N +PW+LPADLA FK TL KP++MGR T++SIG+PLP R+NI Sbjct: 2 IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ Q + S+D+A++A PE+++IGG R++++ LPKA K+ LT I+ Sbjct: 62 VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD +FP++ +W+ H+ D +N + + F L R Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKNPYPFQFLELRR 160 >UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR Length = 175 Score = 229 bits (586), Expect = 2e-59, Method: Composition-based stats. Identities = 73/160 (45%), Positives = 113/160 (70%), Gaps = 2/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+IAA+ R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+ Sbjct: 14 ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ + + S +EA+ +C EI+++GGG++Y Q +P A KLY+T +DAEV Sbjct: 74 VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP++ D+W+ + E+HD D ++++++ F L R+ Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK 173 >UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobacteria RepID=DYR_HAEIN Length = 160 Score = 229 bits (586), Expect = 2e-59, Method: Composition-based stats. Identities = 84/158 (53%), Positives = 107/158 (67%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 SLI A ++ VIG +N MPW+LPADLAWF++NT KPVIMGR T+ESIGRPLP R NI+ Sbjct: 3 FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 LS Q + V W S + A+ D EIM+IGGG +++Q+LPKA KLYLT I E++G Sbjct: 63 LSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDG 122 Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DT FP ++WE F E+ AD QN + F IL R+ Sbjct: 123 DTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160 >UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD Length = 178 Score = 229 bits (586), Expect = 2e-59, Method: Composition-based stats. Identities = 69/159 (43%), Positives = 95/159 (59%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A + +RVIG +N +PW LP DLA FKR TL P+IMGR TWES+GRPLPGR N++ Sbjct: 21 LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S T V ++ A+ ACGD P+ VIGG ++Y Q LP A ++ T + A VE Sbjct: 81 ISRNLRYAAPGATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVHAHVE 140 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP W + A +N + Y F + ER+ Sbjct: 141 GDAFFPYLPSFAWREASRQPQPA--ENGYDYDFVVYERQ 177 >UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO Length = 166 Score = 229 bits (585), Expect = 2e-59, Method: Composition-based stats. Identities = 85/162 (52%), Positives = 117/162 (72%), Gaps = 5/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+ Sbjct: 3 ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62 Query: 62 LSSQPGTDDR----VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 LS + + V WV V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ Sbjct: 63 LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122 Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGDT+FPDY + DW+ + + AD +NSH++ I +R Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164 >UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZ23_9SPHI Length = 164 Score = 227 bits (579), Expect = 1e-58, Method: Composition-based stats. Identities = 70/159 (44%), Positives = 96/159 (60%), Gaps = 1/159 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+LI A A + VIG +N MPW+LP D +FK+NTL VIMGR T+E+IG+ LP R+NI+ Sbjct: 6 ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S V S+ EAI C D E+ VIGG +YEQ LP A K+ LT + +E Sbjct: 66 ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP P++W E H AD +++ Y F++ R+ Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164 >UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacteria RepID=Q0VM07_ALCBS Length = 171 Score = 227 bits (579), Expect = 1e-58, Method: Composition-based stats. Identities = 70/165 (42%), Positives = 101/165 (61%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A A + VIG N +PW LP DL +FK+ T KPVIMGR TWES+ PLPGR NI+ Sbjct: 7 LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ QP + V +VD+AI +V E +++GG +Y L + Q+LYLT Sbjct: 67 ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AEV+GDT FP+Y+ +WE + E A+ N + Y F + ER+ Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171 >UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacteria RepID=Q2Y7L3_NITMU Length = 183 Score = 226 bits (577), Expect = 2e-58, Method: Composition-based stats. Identities = 70/169 (41%), Positives = 102/169 (60%), Gaps = 14/169 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A+A +R IG +NA+PW+LP DL FK T+ P+IMGR T+ESIGR LPGR +II Sbjct: 5 LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSII 64 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDV-----------PEIMVIGGGRVYEQFLPKAQK 109 ++ QP + V S+ EA++AC + E VIGG +++Q LP + Sbjct: 65 ITRQPDYEVPGALVVSSIGEALSACKQIRSGEEGHPDQGNECFVIGGADIFQQMLPLCDR 124 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LY+T I + EGDT+FP+++ +DW V E H D+ Y F L+R Sbjct: 125 LYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR 171 >UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FJX2_FLAJ1 Length = 160 Score = 224 bits (572), Expect = 8e-58, Method: Composition-based stats. Identities = 59/160 (36%), Positives = 91/160 (56%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI +IAA+A + +G N + W+LP D FK T N +IMGR T+ES +PLP R +I Sbjct: 1 MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ Q + + V S+++AIAAC + + +IGGG +Y LP A + +T + Sbjct: 61 IITRQTDYNPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP +W+ V SE + D ++ + Y +E R+ Sbjct: 121 EGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK 160 >UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588 RepID=C7PKU6_CHIPD Length = 164 Score = 223 bits (569), Expect = 2e-57, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A + + VIG+ N +PW+LP D+ +FK T+ KP++MGR ++E +GR LPGR NI+ Sbjct: 3 LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIM 62 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q + + V S++ I EI V GGG +++ L ++YLT + A Sbjct: 63 ITRQKDYTAEGLHIVPSLEAGIEKAKTFGTEEIFVTGGGEIFKMALSIVDRVYLTRVHAT 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V+GDT+FP+++P W+ V +E H+ D +++H+ F++ ER Sbjct: 123 VQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER 162 >UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6 Length = 160 Score = 223 bits (569), Expect = 2e-57, Method: Composition-based stats. Identities = 60/159 (37%), Positives = 90/159 (56%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG +N MPW+LP DL +FK+ T K ++MGR T+ES+G+ LP RK I Sbjct: 1 MIIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ D + S +E +A I V+GG +Y F+ A KL +T IDAE Sbjct: 61 VLTRDKELQLDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + DT FP+ + +++ + E H+ D +N ++Y F ER Sbjct: 121 DADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER 159 >UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA Length = 219 Score = 222 bits (567), Expect = 3e-57, Method: Composition-based stats. Identities = 67/161 (41%), Positives = 95/161 (59%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A A + VIG +N +PW LP DLA+FKR T+ P++MGR T ESIGRPLPGR+NI+ Sbjct: 56 LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 115 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D S+ +A+A E +IGG ++Y + L A KL +T ID + Sbjct: 116 VTRDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 175 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP +P WE+V + H A N +Y F + R+ Sbjct: 176 FEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK 216 >UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P459_9PROT Length = 177 Score = 221 bits (565), Expect = 5e-57, Method: Composition-based stats. Identities = 54/158 (34%), Positives = 83/158 (52%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLI A+A +R IG+ N +PW P DL FK T+ +IMGR T++SIG+PLPGR ++ Sbjct: 19 LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVV 78 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + + S+ EA+ C EI V+GG +Y Q + LY+T I +V Sbjct: 79 ITRNNDLEIEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVA 138 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD HFP+ + W+ E + + F + Sbjct: 139 GDAHFPEIDKAFWQETSREMRSQETPQPMDFHFVTYRK 176 >UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001787F40 Length = 162 Score = 221 bits (565), Expect = 5e-57, Method: Composition-based stats. Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MIS+I A+ D+VIG+ MPW LP D+A+FK TL+K ++MGR TW+S G +PLP RKN Sbjct: 1 MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60 Query: 60 IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ T+D+ + ++ A+ + E+MVIGG ++YE LPKA +LY T ID Sbjct: 61 IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGDT+FP+ D+W+ V D +N ++Y F ER+ Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162 >UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobacteria RepID=Q15PF1_PSEA6 Length = 171 Score = 221 bits (565), Expect = 5e-57, Method: Composition-based stats. Identities = 81/168 (48%), Positives = 107/168 (63%), Gaps = 11/168 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+++AA+A RVIG+ N MPW++PADL FKR TL KP++MGR T+ESIGR LPGR NI+ Sbjct: 4 IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAAC----------GDVPEIMVIGGGRVYEQFLPKAQKL 110 ++S + V S ++AIA E+MVIGGG VY+ FLP A +L Sbjct: 64 ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 YLT ID + GDT+FP+Y W+ + SE +D D +N HSY F L R Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171 >UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XJD1_MEIRU Length = 171 Score = 221 bits (563), Expect = 8e-57, Method: Composition-based stats. Identities = 62/159 (38%), Positives = 94/159 (59%), Gaps = 5/159 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ + A+ +R IG +PW+LP DL F+ TL K V+MGR T+ESIGRPLP R+N++ Sbjct: 5 IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVV 64 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 L+ P + V V ++++A+ E+MVIGGG +Y FLP L+LT ++ V Sbjct: 65 LTRDPAFAAEGVEVVHTLEDALKL---DDELMVIGGGEIYTLFLPLVTHLHLTLVETVVP 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + D FP + P W + E H AD ++ ++ + LER Sbjct: 122 DADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER 160 >UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC Length = 163 Score = 220 bits (562), Expect = 1e-56, Method: Composition-based stats. Identities = 62/158 (39%), Positives = 102/158 (64%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ +++IG NA+PW LPADLA+FK+ T+ K V+MGR T++SIGRPL R+NII Sbjct: 3 LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNII 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S++ A+ E+M++GG YEQ + K ++Y+T ++ + + Sbjct: 63 VSRNTKLKVDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFD 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP+++ + + E H D +N H++ F IL++ Sbjct: 123 GDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK 160 >UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1 Length = 169 Score = 219 bits (560), Expect = 2e-56, Method: Composition-based stats. Identities = 67/165 (40%), Positives = 97/165 (58%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +S + A+A + VIG +N++PW L D+A+FKR T+ KPVIMGR TWES+ R PLPGR NI Sbjct: 3 VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRKPLPGRPNI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +++ + + S EA+ A+ E+MVIGG ++Y + A +LY+T Sbjct: 63 VVTRDAQYEAEGAEIAASAVEALRRGRELASASGADEVMVIGGAQLYAEMFDDATRLYIT 122 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A EGD FP ++ W V E H A ++S Y F +LER Sbjct: 123 EVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER 167 >UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3 Length = 167 Score = 219 bits (560), Expect = 2e-56, Method: Composition-based stats. Identities = 61/161 (37%), Positives = 93/161 (57%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI+++ A+ + IG +N + W+LP DL FK T P+IMGR T+ESIGRPLP R NI Sbjct: 1 MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNI 60 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++S + + V V S+ EA+ + E + VIGGG +YEQ + A KL +T + AE Sbjct: 61 VVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAE 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D FP + WE D D ++++ +CF+ ++ Sbjct: 121 INADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK 161 >UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67JQ2_SYMTH Length = 165 Score = 219 bits (558), Expect = 3e-56, Method: Composition-based stats. Identities = 66/153 (43%), Positives = 87/153 (56%), Gaps = 4/153 (2%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 + +R IG E +PW LPA++ F+R T+ K V+MGR T+ESIG PL GR NI+L+ PG Sbjct: 1 MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG 60 Query: 68 T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 SV E + D + VIGG VY QFLP A ++ LT ID + EGD FP Sbjct: 61 FRAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFP 117 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D+WE V S H D +N + + E RR Sbjct: 118 AWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR 150 >UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP Length = 259 Score = 219 bits (558), Expect = 4e-56, Method: Composition-based stats. Identities = 68/163 (41%), Positives = 93/163 (57%), Gaps = 5/163 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 +++IAA A + VIG N +PW LP DLA F+ T PVIMGR TWES+ RPLPGR+ Sbjct: 3 LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLPARFRPLPGRR 62 Query: 59 NIILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 NII+S G V V S++ A+ VIGG R+YE LP A +L+LT ID Sbjct: 63 NIIVSRGGVRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEID 122 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + EGD +FP+++ + A+A N+ +Y F R+ Sbjct: 123 EDFEGDVYFPEFDRSAFVEHHRMRRQAEAPNTFTYSFAHYRRK 165 >UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EUV9_DICNV Length = 164 Score = 218 bits (557), Expect = 4e-56, Method: Composition-based stats. Identities = 63/159 (39%), Positives = 92/159 (57%), Gaps = 1/159 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LIAA ++RVIG + MPW+LP DL FK+ T +IMGR T++S+ +PLP RKNI+ Sbjct: 6 IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIV 65 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S V ++ EA+A C + ++ +IGGG +Y + +A L +T I E+ Sbjct: 66 ISHSGQPLHADVAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTELL 125 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP P DW+ ADA+N+ + F +RR Sbjct: 126 GDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR 164 >UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved in trimethoprim resistance n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YTZ2_9FLAO Length = 165 Score = 218 bits (557), Expect = 4e-56, Method: Composition-based stats. Identities = 61/160 (38%), Positives = 93/160 (58%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M +++ A+ IG EN + W+LP DL FK T PVIMGR T+ESIG+ LP R NI Sbjct: 1 MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNI 60 Query: 61 ILSSQPG-TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++S + ++ + V S+ EA+ + E+ VIGGG +YEQ + +L +T + A+ Sbjct: 61 VVSRKKDWFEEGILIVGSIKEALKFAKKIDEEVFVIGGGNIYEQTMDVVDRLEVTLVKAD 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +E DT FP +P W+ H+ D +N + +CF+ ER Sbjct: 121 LEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER 160 >UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF Length = 170 Score = 217 bits (555), Expect = 6e-56, Method: Composition-based stats. Identities = 71/164 (43%), Positives = 105/164 (64%), Gaps = 8/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAAL +RVIG++N+MPW+LP D +FK TL KP+IMGR TW+S+GRPLPGR NI+ Sbjct: 7 LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66 Query: 62 LSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S Q G + S++ A+ A V E+M+IGG ++Y Q L +A +LYLT Sbjct: 67 VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGD FP+++ + W+ V + + A + +Y FE+ E+ Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPA-EGDKPAYNFEVWEK 169 >UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT Length = 169 Score = 217 bits (555), Expect = 8e-56, Method: Composition-based stats. Identities = 62/169 (36%), Positives = 89/169 (52%), Gaps = 10/169 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MISLIAA+A + IG + W LP D+ +F+ T K VIMGR TWES+ RPLP R Sbjct: 1 MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPPAYRPLPNR 60 Query: 58 KNIILSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS P S+++A+ G E+ +IGG +Y Q +P A +LY+T + Sbjct: 61 RNIVLSRNPAYLPRGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVA 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADA------QNSHSYCFEILERR 159 E GD FPD +W + + A + ++ F + ERR Sbjct: 121 EESPGDAFFPDVASGEWREISRRVGRSRAAGSALRDQAPAFDFVVYERR 169 >UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3 RepID=B8KL97_9GAMM Length = 182 Score = 217 bits (554), Expect = 8e-56, Method: Composition-based stats. Identities = 68/165 (41%), Positives = 99/165 (60%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+LI A A + VIG +NA+PW LP DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+ Sbjct: 6 IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIV 65 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S PG V V+S+++A+ D+ E+M+IGG ++Y LP A ++YLT Sbjct: 66 ISRDPGYSAAGVRSVQSLEKALELAKDIAVIDGSSELMIIGGAQIYALALPLASRIYLTR 125 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + E GD P + W+ + + AD + ++ F R+ Sbjct: 126 VHVEPAGDAFLPAIDWAHWKESGRQENPADG-SVPAHTFLEYTRQ 169 >UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CYL9_PAESJ Length = 163 Score = 217 bits (553), Expect = 1e-55, Method: Composition-based stats. Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I++IAA+ R IG+ N +PW LPA++A+F R+T K V+MGR T+ES+ +PL R N++ Sbjct: 3 ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ QP + V SV EAI G+ E+MVIGG +Y QFLP A K+ LT +D +E Sbjct: 63 ITRQPEYAKEGCEVVHSVQEAIDRYGEG-ELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121 Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP + +WE V +E ++D +N+ S+ F+ RR Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161 >UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD Length = 195 Score = 217 bits (553), Expect = 1e-55, Method: Composition-based stats. Identities = 67/167 (40%), Positives = 98/167 (58%), Gaps = 10/167 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+L+AA++ +RVIG++N +PW+LP DL +FK T++KP++MGR T+ESIGRPLPGR NI+ Sbjct: 19 IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIV 78 Query: 62 LSSQPGT---DDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 ++ G D + + A+ A V +I VIGGG ++ + LP A +LYL Sbjct: 79 VTRDRGYAQDHDGIRVCHDLASALDMADGQAIIDGVEDICVIGGGEIFAEALPCATRLYL 138 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T +D EVEGD FP ++ +W+ Y F RR Sbjct: 139 TEVDIEVEGDAWFPAFDAREWQETQRVPGQGGE-GKPEYAFVHYTRR 184 >UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIZ1_FIBSS Length = 163 Score = 217 bits (553), Expect = 1e-55, Method: Composition-based stats. Identities = 60/162 (37%), Positives = 87/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS I A++ + VIG + +PW+L ADL FK T +I+GR ++ IGRPLP R N Sbjct: 2 LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNY 61 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAA--CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+ S+ EAI A E +IGG VY + +P +KLYLT + + Sbjct: 62 VLTRNKDFQAPGCIVCSSLGEAIEAARAAGETECFIIGGAAVYREAMPLVEKLYLTRVLS 121 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 VEGD FP++ D ++ +E AD +N FEI R+ Sbjct: 122 HVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK 162 >UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobiales RepID=Q2K6G9_RHIEC Length = 172 Score = 216 bits (552), Expect = 2e-55, Method: Composition-based stats. Identities = 65/164 (39%), Positives = 100/164 (60%), Gaps = 7/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 ++IAA+A + IG E MPW L +DL FK TL KPV+MGR T++SIG+PLPGR N+++ Sbjct: 7 TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVI 66 Query: 63 SSQPGTD-DRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 S Q D ++ S+ EA+ A EI +IGGG++Y Q + A ++Y+TH+ Sbjct: 67 SRQAAIDHSDISMAHSLAEALEAAERLALQTGAGEICIIGGGQIYAQAIDLADRMYITHV 126 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +A+++GD FP +P W++ A ++S+ F + ERR Sbjct: 127 EADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR 170 >UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR Length = 163 Score = 216 bits (551), Expect = 2e-55, Method: Composition-based stats. Identities = 69/160 (43%), Positives = 98/160 (61%), Gaps = 6/160 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+A +RVIG NA+PW++PAD F+ TL PVIMGR T+ES+ PLPGRKNI Sbjct: 2 VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNI 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ Q + + A+A G+ EI + GGG +Y Q LP A ++YLT I + Sbjct: 62 IITRQMDYRAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT FP+ P+ + V E +N+ Y F + ++R Sbjct: 122 DGDTRFPEI-PERFVEVGRET----VENAIPYSFVLYDKR 156 >UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU Length = 191 Score = 216 bits (551), Expect = 2e-55, Method: Composition-based stats. Identities = 68/162 (41%), Positives = 101/162 (62%), Gaps = 5/162 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLI A+A + IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+ Sbjct: 27 IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86 Query: 61 ILSSQPGTD--DRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 ++S + + AIAA +V EIM++GG ++Y LP +LYLTH+ Sbjct: 87 VISRSLEKEALPGCLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLYLTHV 146 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 A +EGDT P ++ +F E H D +N + Y FEI + Sbjct: 147 HANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEIWD 188 >UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698640 Length = 158 Score = 215 bits (549), Expect = 3e-55, Method: Composition-based stats. Identities = 71/149 (47%), Positives = 97/149 (65%), Gaps = 1/149 (0%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 +A +RVIG N MPW+LPADL FK T+ KP++MGR TWES+ LP R +I+++ P Sbjct: 1 MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60 Query: 68 T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 + T V S+DEAIAA G+V EIMV+GGG Y + LP+ ++YLT +DAE EGDT FP Sbjct: 61 YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEI 155 D + +W E H AD ++++ Y Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPYSLHR 149 >UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO Length = 164 Score = 215 bits (548), Expect = 4e-55, Method: Composition-based stats. Identities = 60/161 (37%), Positives = 90/161 (55%), Gaps = 3/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++IAA+A + +G N + W+LPADL FK+ T ++MGR+T+ESIGRPLP R I Sbjct: 1 MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 I++ + SV++A+ D +I +IGG +VYE + A L +T + Sbjct: 61 IITKNEEYVQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMKHDFADALDITLVHH 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E E D +FP+ +P W V E AD +N Y F ++ Sbjct: 121 EFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSFIRYKK 161 >UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA Length = 166 Score = 214 bits (547), Expect = 5e-55, Method: Composition-based stats. Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 7/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I+LI A A + VIG NAMPW+LP DLA FKR T PVIMGR TW+S+ RPLPGR Sbjct: 6 INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65 Query: 59 NIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N++++ QP S+ +A+A C E+ VIGG ++Y P A ++ +T I Sbjct: 66 NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQ 125 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GD P ++W+ E H + + + F E+ Sbjct: 126 DFDGDAFAPPLG-EEWQETAREAHVSS--HGLPFSFVTFEK 163 >UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1CZU3_MYXXD Length = 159 Score = 214 bits (547), Expect = 6e-55, Method: Composition-based stats. Identities = 66/160 (41%), Positives = 89/160 (55%), Gaps = 6/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S I A+A +RVIG N +PW LPADLA FKR T+ ++MGR T+ESIGRPLPGR I+ Sbjct: 3 LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIV 62 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q V SVDEA++ E+ + GG +Y Q + + Q++YLTHI Sbjct: 63 VTRQRDFAPPGVQVAHSVDEALSLAKASGDSEVFIAGGADLYAQTMDRVQRIYLTHIARN 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FPD + W V + H + F ER Sbjct: 123 FPGDTWFPDVDLSGWTCVEEQAHPDAE---PPHTFLTYER 159 >UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobacteria RepID=A6UB22_SINMW Length = 187 Score = 214 bits (546), Expect = 7e-55, Method: Composition-based stats. Identities = 67/165 (40%), Positives = 96/165 (58%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I ++ A+A++ VIG E +PW LP DL FK T+ KPVIMGR TW +IGRPLPGR NI+ Sbjct: 14 IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIV 73 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ + S++ A+A + EI VIGGG +Y Q + A L++T Sbjct: 74 VTRNRAFEAPGAEVAPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTE 133 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AEV+GDT FP+ +P +E V E + ++SH+ F RR Sbjct: 134 VQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR 178 >UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D66 Length = 161 Score = 214 bits (546), Expect = 8e-55, Method: Composition-based stats. Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A++ + VIG+ N +PW++P DL FK T+ P++MGR T++SIGRPLPGRKNI+ Sbjct: 4 ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIV 63 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + + V V S++ +A D + VIGG ++Y+ FL A LY+T +D++V Sbjct: 64 ITRNEDSIIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVA 123 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD HFP W+ V E +++ + F R+ Sbjct: 124 GDAHFPKLSTSQWKEVGRE--KLVSKDDLHFSFVDYIRQ 160 >UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC Length = 175 Score = 214 bits (546), Expect = 8e-55, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 89/161 (55%), Gaps = 3/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M++ I A + +IG E+ +PW LP DL +FK+ T ++MGR T+E +G RPLP R+ Sbjct: 1 MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGSRPLPNRQT 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVI-GGGRVYEQFLPKAQKLYLTHIDA 117 I+L+ + V + SV++ +A + I I GG VY++FLP LY T I Sbjct: 61 IVLTRDSSYKAEGVHVMHSVEDVLALEKETDGIFFIAGGSAVYQEFLPFCTILYRTVIHH 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD +FP + DW + + + D +N + + FE +R Sbjct: 121 VFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR 161 >UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii HA RepID=A5CVJ7_VESOH Length = 163 Score = 214 bits (546), Expect = 9e-55, Method: Composition-based stats. Identities = 60/158 (37%), Positives = 100/158 (63%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ + +IG +N++PW LPADLA+FK+ T+ K ++MGR T +SIGR LP R+NII Sbjct: 3 LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNII 62 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S+D A++ + E+M++GG Y+Q + K +LY+T + + Sbjct: 63 VSKNTKFKADNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFD 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD +FP+++ + + E H D +N ++Y F +L+R Sbjct: 123 GDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR 160 >UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2 Length = 171 Score = 214 bits (545), Expect = 9e-55, Method: Composition-based stats. Identities = 62/169 (36%), Positives = 99/169 (58%), Gaps = 11/169 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + ++ A A + VIG+ N +PW + ADL FK+ T+ P+IMGR T++SIG+PLPGR I+ Sbjct: 3 LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIV 62 Query: 62 LSSQ-----PGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKL 110 ++ Q G +D+V S++ A+ + E M++GG ++Y Q L + K+ Sbjct: 63 VTRQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKV 122 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +LT + AE+EGD FP+ + + W V + AD +N + Y F L RR Sbjct: 123 HLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR 171 >UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2 Length = 162 Score = 214 bits (545), Expect = 9e-55, Method: Composition-based stats. Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII Sbjct: 3 ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS + ++ +A + EIMVIGGG +++Q +P+A +LYLT I AE Sbjct: 63 LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +EGDT F +++ +W V ++ + D QN++ F ILER+ Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162 >UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA Length = 163 Score = 214 bits (545), Expect = 1e-54, Method: Composition-based stats. Identities = 64/158 (40%), Positives = 89/158 (56%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+ +G+ N + LPADL FK T+ KP+IMGR T+ESIG+PLPGR NI Sbjct: 3 LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++S + V V S+ +AI D E+M+IGG ++Y Q + A +LY+T I + Sbjct: 63 VISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFM 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 D FP W E+ D +N + F I ER Sbjct: 123 ADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER 160 >UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE Length = 167 Score = 213 bits (543), Expect = 2e-54, Method: Composition-based stats. Identities = 66/167 (39%), Positives = 92/167 (55%), Gaps = 12/167 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LI A A + VIG +N MPW+LP D+A FK T VIMGR TW+S+ RPLPGR Sbjct: 3 IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPPRFRPLPGRS 62 Query: 59 NIILSSQPG-----TDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYL 112 NI+++ Q D+V S+ EA+ ++ ++ VIGG ++Y Q LP A + + Sbjct: 63 NIVVTRQADWQAEPASDQVLRAASLSEALELGRNLSQDVWVIGGAQIYAQALPLADAVEV 122 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I + EGD P+ + W++V H + N YCF ERR Sbjct: 123 TEIGRDFEGDAFAPELG-EQWQAVSRSEHVS--ANGLPYCFVRFERR 166 >UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK Length = 162 Score = 212 bits (542), Expect = 2e-54, Method: Composition-based stats. Identities = 51/160 (31%), Positives = 81/160 (50%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG +N +PW+LPADL FKR T + ++MGR T++S+G PLP RKN+ Sbjct: 1 MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNV 60 Query: 61 ILSS-QPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ + + + S+D+ + I VIGG ++ K +T ID + Sbjct: 61 VLTRSRSFQAEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKF 119 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E DT P +WE V + D +N + + + R+ Sbjct: 120 EADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK 159 >UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110 RepID=C5CTW3_VARPS Length = 177 Score = 212 bits (541), Expect = 3e-54, Method: Composition-based stats. Identities = 63/163 (38%), Positives = 94/163 (57%), Gaps = 7/163 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LI A A + VIG + +PW+LP D+ FK+ T PV+MGR TW+S+ RPLPGR+ Sbjct: 10 IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69 Query: 59 NIILSSQPG-TDDRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 NI+++ Q + V S+ EA+A C + VP++ +IGG ++Y + P AQ++ +T + Sbjct: 70 NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQVVVTEL 129 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGD H P+ P W E H A+ +Y F ER Sbjct: 130 AHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER 171 >UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR Length = 163 Score = 212 bits (540), Expect = 3e-54, Method: Composition-based stats. Identities = 58/162 (35%), Positives = 87/162 (53%), Gaps = 6/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LIAA+A +RVIG +N + WNLP D+A FK T + V+MGR TWES+ RPLPGR+ Sbjct: 4 IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPPRFRPLPGRR 63 Query: 59 NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N+++S Q S++ A+ + +IGG ++Y+Q + A +L +T +D Sbjct: 64 NVVISRQADYAAPGAEVANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEITDVDL 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E GD FP+ DW + Q+ + F R+ Sbjct: 124 EPAGDAWFPEIAATDWSVTQKNTPPS--QSGTGFSFVTYRRK 163 >UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteobacteria RepID=B3PTQ3_RHIE6 Length = 172 Score = 212 bits (540), Expect = 4e-54, Method: Composition-based stats. Identities = 64/164 (39%), Positives = 103/164 (62%), Gaps = 7/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 ++IAA+A + +IG + MPW L +DL FK TL KPV+MGR T++SIG+PLPGR N+++ Sbjct: 7 TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVI 66 Query: 63 SSQPGTD-DRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 S Q D V S+ EA+ A V EI ++GGG++Y Q + A ++ +TH+ Sbjct: 67 SRQAAIDHPDVAMAHSLAEAMDAAERLARETGVDEICIVGGGQIYAQAINLADRMCITHV 126 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +A+++GD FPD +PD W++ + A ++S+ + + +RR Sbjct: 127 EADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR 170 >UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA Length = 180 Score = 211 bits (539), Expect = 5e-54, Method: Composition-based stats. Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 I IAA +RVIG + MPW+LPAD A F+ ++ KP IMGR ++++ R PLP R NI Sbjct: 17 IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRKPLPERVNI 76 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ D S +EA+ GD PEI +IGG +Y + + +L +T I AE+ Sbjct: 77 VLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAEL 136 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT FP+ P +WE F AD +N + F+ RR Sbjct: 137 DGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR 175 >UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11US6_CYTH3 Length = 161 Score = 211 bits (538), Expect = 6e-54, Method: Composition-based stats. Identities = 64/162 (39%), Positives = 88/162 (54%), Gaps = 5/162 (3%) Query: 1 MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59 MI S+I A + +R IG+ N +PW+LPADL FK T+ +IMGR T+ESIG PLPGR + Sbjct: 1 MIRSIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTS 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+++ T S+ EA IA + E VIGG + ++ + KLYLT I Sbjct: 61 IVVTRNKDLVFAGCTMAHSLAEAFEIAQNNNDSEAFVIGGAELIKEAINSCDKLYLTTIH 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT DW+ H D +N++SY F E+ Sbjct: 121 QNFEGDTFLDAL-ASDWKETEHVVHAPDDKNAYSYSFITYEK 161 >UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA Length = 166 Score = 210 bits (536), Expect = 1e-53, Method: Composition-based stats. Identities = 62/158 (39%), Positives = 87/158 (55%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A+ RVIG +N +PW + +D + K T +I+GR +SIGR LP R+NII Sbjct: 7 ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNII 66 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ + S++ A C + E+ + GG ++Y FLP +K+Y+T I E E Sbjct: 67 LTRDKNFNFKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFE 126 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP DDW+ V E D +N + Y F I ER Sbjct: 127 GDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER 164 >UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO Length = 162 Score = 210 bits (536), Expect = 1e-53, Method: Composition-based stats. Identities = 63/157 (40%), Positives = 90/157 (57%), Gaps = 3/157 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I++IAA A + IG NAMPW++P D A+FK TL KPVIMGR TWES+ +PLPGR+NI Sbjct: 4 ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNI 63 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S Q V S++ A+A C E +++GG ++Y Q +P A L +T +D V Sbjct: 64 VISRQADYCAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 EGD FP+ + W ++ +Y F Sbjct: 124 EGDAFFPEIDRTHWREAERTERRVSSK-GVAYTFVHY 159 >UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QWB5_9PLAN Length = 171 Score = 210 bits (536), Expect = 1e-53, Method: Composition-based stats. Identities = 59/159 (37%), Positives = 93/159 (58%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLI A+ + +IG + +PW + ADL F+ T+ +IMGR TW+S+GR LPGR +I+ Sbjct: 11 LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIV 70 Query: 62 LSSQPG--TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ + + V S+DEAIA E +IGGG +Y Q + + Q+LY+T ++A + Sbjct: 71 LTRKADLVLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANI 130 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT FP ++P + + H A + ++ F ER Sbjct: 131 EGDTWFPAWDPSKFRLLEETSHPA-EGTTPAFTFTRYER 168 >UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organisms RepID=Q5P234_AZOSE Length = 167 Score = 210 bits (535), Expect = 2e-53, Method: Composition-based stats. Identities = 65/159 (40%), Positives = 92/159 (57%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +IAA A + IG +N +PW L +DLA FK T+ PV+MGR TWES+GRPLP R+N++ Sbjct: 8 VIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNLV 67 Query: 62 LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + A+ A GD + VIGG +Y Q L A L LT + A+V Sbjct: 68 VTRDRSYSATGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTEVHADVA 126 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD +FP ++ D++ V E HDADA N S+ F R+ Sbjct: 127 GDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK 165 >UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XMY9_HIRBI Length = 182 Score = 209 bits (534), Expect = 2e-53, Method: Composition-based stats. Identities = 67/166 (40%), Positives = 93/166 (56%), Gaps = 8/166 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +++I A A + VIG++ +PW L DL +FK TL KPVIMGR TWES+ +PL GR N+ Sbjct: 15 LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPFKPLKGRANL 74 Query: 61 ILSSQPGTDD-RVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 ++S + D S+ AIAA DV E+M+IGGG +Y LY+T Sbjct: 75 VVSRRHDFDAQGARVFPSLGVAIAAGRAIADQTDVEEVMIIGGGAIYTAAFENVDVLYVT 134 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ E EGDT FP+ + D W V H AD N H++ L R+ Sbjct: 135 EVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK 180 >UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP Length = 170 Score = 209 bits (534), Expect = 2e-53, Method: Composition-based stats. Identities = 51/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +S+I A+A + IG +N + W+LP DL FK T +IMG++T+ S+ LP R+NI Sbjct: 3 LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPNGALPNRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 ++SS D V ++ A+ A E+ +IGG ++Y LP A K+Y + ++ Sbjct: 63 VVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFP 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT+FP+++ +W + + D +N ++ I +R Sbjct: 123 EADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR 161 >UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HTR7_9SPHI Length = 166 Score = 209 bits (534), Expect = 2e-53, Method: Composition-based stats. Identities = 58/161 (36%), Positives = 92/161 (57%), Gaps = 4/161 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLIAA+A + VIG N + W +P D FK T ++MGR T+ES+G+PLP R +++ Sbjct: 3 ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLV 62 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +S + ++V++A C + ++ VIGGG +Y+Q + A +L +T +DA Sbjct: 63 ISRNKNYKVPEGHHLFENVEDAFIYCNKLGIEKLYVIGGGEIYKQTISIADELLITEVDA 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP+ + + W+ V E +D N H + F ER Sbjct: 123 TPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER 163 >UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB Length = 170 Score = 208 bits (531), Expect = 4e-53, Method: Composition-based stats. Identities = 64/164 (39%), Positives = 94/164 (57%), Gaps = 5/164 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+ I A + + VIG N +PW+LP DL +F++ T NK V+MGR T+ES G + LP R N Sbjct: 1 MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGSKALPKRLN 60 Query: 60 IILSSQPGT---DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHI 115 IIL+S D V V S EA+ + + VIGG VYE F+ A +L +T + Sbjct: 61 IILTSNMDFKSNDPEVKIVHSPIEAVNTAKEQHLPLYVIGGASVYESFMNMADRLLITLV 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DA ++GDT P++ + V H D ++++S+ F ER+ Sbjct: 121 DANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK 164 >UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS Length = 165 Score = 208 bits (531), Expect = 4e-53, Method: Composition-based stats. Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII Sbjct: 3 ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS D S+++A+ + EIM++GGG +++Q +P A KLYLT I A Sbjct: 63 LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +EGDT F +++ W+ + ++ + D QNS+ F IL++ Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161 >UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP Length = 165 Score = 208 bits (531), Expect = 4e-53, Method: Composition-based stats. Identities = 58/161 (36%), Positives = 84/161 (52%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+IAA+A IG + ++P+D+ FK T VIMGR T+ES+ PLP RKN+ Sbjct: 4 ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPVAPLPNRKNV 63 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L++ P +S+ A+ C EI +IGG VY Q L A K+Y+T I E Sbjct: 64 VLTTMPEAGFVNCFACESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEF 123 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + + FP D WE E + AD +N + Y + R+ Sbjct: 124 PDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK 164 >UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XTJ0_POLNS Length = 162 Score = 208 bits (530), Expect = 5e-53, Method: Composition-based stats. Identities = 66/158 (41%), Positives = 93/158 (58%), Gaps = 5/158 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A + + VIG +N MPW + ADL +FKR T+ PVIMGR TWESIGR LPGR+NI+ Sbjct: 6 ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIV 65 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S V S+DEA+ + + P + VIGG +++ Q KA +LY+T ID ++E Sbjct: 66 VSRNASYPISGGELVGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLDIE 125 Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 GDT F W+ V ++ ++ F LE Sbjct: 126 GGDTFFEVPNASAWKEVERTPG---SEGEITFSFITLE 160 >UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonellaceae RepID=D1BNV5_VEIPT Length = 164 Score = 207 bits (527), Expect = 1e-52, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 88/161 (54%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M++LI A+A +RVIG +N + W+LP DL +FK T +IMGR T+ES+ LP R++ Sbjct: 1 MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHW 60 Query: 61 ILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +++ G D + V + + A A + VIGG +VYE FLP +Y+T +D E Sbjct: 61 VITRDKGFDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHE 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GD FP++ D + D +N + + F R+ Sbjct: 121 FDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFVTYRRK 161 >UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FSY3_9FIRM Length = 169 Score = 205 bits (524), Expect = 3e-52, Method: Composition-based stats. Identities = 59/163 (36%), Positives = 91/163 (55%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M++L+ A IG +N +PW+LP DL +FK+ TL ++MGR T+ES+G R LPGR + Sbjct: 1 MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGCRLLPGRTS 60 Query: 60 IILSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+ Q + + V ++ EAI A + E+MVIGG ++ LP A ++ T I Sbjct: 61 YVLTRQEDYKSEIEGLHRVHNL-EAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIK 119 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 A DT D + D W+ V + D +N +++ FE RR Sbjct: 120 ATFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR 162 >UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus asiaticus 5a2 RepID=B3ER85_AMOA5 Length = 164 Score = 205 bits (524), Expect = 3e-52, Method: Composition-based stats. Identities = 65/163 (39%), Positives = 91/163 (55%), Gaps = 4/163 (2%) Query: 1 MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59 MI S+I A AV+ VIG + +PW++PADL FK T VIMGR T+ES+ LP RK Sbjct: 1 MIKSIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKI 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IILS + T V S++ A+ + E+ + GG VY + L K+YLT I Sbjct: 61 IILSQSLNYKVEDCTVVPSLEMALEIANQANETEVFIAGGAAVYREALGIVDKIYLTVIH 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +VEGDT FP + W V H+ D +++++Y F L +R Sbjct: 121 TDVEGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR 163 >UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae RepID=Q134B2_RHOPS Length = 179 Score = 205 bits (524), Expect = 3e-52, Method: Composition-based stats. Identities = 65/164 (39%), Positives = 91/164 (55%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I +I A+A + VIG NA+PW L +D FK+ TLNKPVIMGR T++SIGRPLPGR NI+ Sbjct: 12 IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIV 71 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ V S + A E++V+GG +Y +LP+A + LT Sbjct: 72 VTRDTHFQAAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTE 131 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GDT FP +PD WE V H A ++S + + R Sbjct: 132 VHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR 175 >UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadaceae RepID=B2I6E9_XYLF2 Length = 188 Score = 205 bits (523), Expect = 4e-52, Method: Composition-based stats. Identities = 72/163 (44%), Positives = 97/163 (59%), Gaps = 4/163 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 ++SLIAAL R IG +N +PW+LP DL FK TL +PV+MGR T S+GRPLPGR N+ Sbjct: 24 IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNL 83 Query: 61 ILSSQPGTD-DRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+ + V S+D AI AA + VIGGG +Y LP A +YLTH+D Sbjct: 84 VLTRSGHVPFSEMRAVDSLDAAIVQAAAEGADTLSVIGGGELYALTLPHANAMYLTHVDV 143 Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V G DT+FP ++ DWE E H D ++++ + F RR Sbjct: 144 AVAGADTYFPMFDAVDWEIKNREPHQGDGRHAYPFTFIDYCRR 186 >UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI Length = 162 Score = 205 bits (522), Expect = 4e-52, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 85/161 (52%), Gaps = 7/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + LI A A + VIG + +PW+LP D+A F++ T VIMGR TW+S+ RPLPGR Sbjct: 3 LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRS 62 Query: 59 NIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 NI+++ Q D S+++A+A C VIGG ++Y Q LP A + +T I+ Sbjct: 63 NIVVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQ 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GD H P +W + Q+ ++ F R Sbjct: 123 DFDGDAHAPTLGA-EWVEIRRSRQP--DQHGLAFSFVRYAR 160 >UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris F0302 RepID=D1QNC5_9BACT Length = 160 Score = 205 bits (522), Expect = 5e-52, Method: Composition-based stats. Identities = 65/161 (40%), Positives = 95/161 (59%), Gaps = 4/161 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 ++SLIAA+A +R IG +N + +++ DL FKR T+ VIMGRHT+ES+ LP RKN Sbjct: 2 ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPNGALPHRKN 61 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++S + T V S EA+ C E+ VIGG +VY++ + +A +LYLT IDA Sbjct: 62 IVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALA 121 Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E D +FP + + W V E H N ++ F + +RR Sbjct: 122 EQADAYFP--DYNSWHLVAHEAHKKSEDNPFAFAFTVYQRR 160 >UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W5S3_DYAFD Length = 183 Score = 204 bits (521), Expect = 5e-52, Method: Composition-based stats. Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A A + IG +N + W L DL FK+ TL P+IMGR T+ESIG+PLPGR +I+ Sbjct: 20 ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIV 79 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D V V S+DEA+ D E+ ++GGG +YEQ A +YLT + Sbjct: 80 ITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVHTS 139 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V GDT F EP+ W H+ D ++ + F ++ Sbjct: 140 VVGDTFFSIREPEAWTETERISHEPDERHIFPFEFINYIKK 180 >UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W102_DYAFD Length = 167 Score = 204 bits (521), Expect = 6e-52, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 2/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+IAA++ + VIG+ N++PW+LP + A F++ T K IMGR ++E+ +N+I Sbjct: 7 LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVI 66 Query: 62 LSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S+P + RV + + + AIA D ++ V+GG V+EQ LP A ++YLT + A+V Sbjct: 67 ITSRPPAQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQV 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP ++ DDW+ SEFH AD +++++ + R+ Sbjct: 127 EGDAFFPAFDSDDWQLADSEFHGADDDHAYAFSMNLYIRK 166 >UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI Length = 162 Score = 204 bits (521), Expect = 6e-52, Method: Composition-based stats. Identities = 58/160 (36%), Positives = 86/160 (53%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A + +IG +PW+LP D+A+FK+ T+ P+I G T+ S RPLPGR+NI Sbjct: 1 MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +LS D V + SV++ P+ V GG ++ Q L K +LY T I + Sbjct: 61 VLSRHGDFPDGVLVISSVEQLCELVDKNPKENYFVTGGANLFGQLLDKVDRLYRTKIHHQ 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+ P+ + + V S D +N + + FE+ ER Sbjct: 121 FTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER 160 >UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8 Length = 164 Score = 204 bits (519), Expect = 1e-51, Method: Composition-based stats. Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 IS+I A+A + IG EN + + LP DL FK T +IMGR T+ES+ + LP R+NI Sbjct: 3 ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKGALPNRRNI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAE 118 +LS + G +++ A++ C + EI +IGG +Y++ + AQ+LY+T I D Sbjct: 63 VLSRREGAVFAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIDDTS 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E D +FP+ + ++W+ E H D ++ + Y F R Sbjct: 123 KEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSFINYSR 162 >UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS77_9GAMM Length = 162 Score = 203 bits (518), Expect = 1e-51, Method: Composition-based stats. Identities = 61/153 (39%), Positives = 88/153 (57%), Gaps = 1/153 (0%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 +A +RVIG + +PW LPAD+ F T KP++MGR ++IGR LPGR NI+LS P Sbjct: 1 MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPA 60 Query: 68 TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 V ++ A+A EIM+IGG ++Y FL +A ++YLT + VEGD FP Sbjct: 61 HRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAFFP 120 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + +W+ + ADA N+++ F L RR Sbjct: 121 HLDAAEWQESARQSRLADADNAYALTFLTLLRR 153 >UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XKH5_9CAUL Length = 175 Score = 203 bits (517), Expect = 2e-51, Method: Composition-based stats. Identities = 66/169 (39%), Positives = 98/169 (57%), Gaps = 12/169 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I+L+ A A + VIG + +PW L +DL FK+ TL KP IMGR TWES+ RPLPGR N+ Sbjct: 6 IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPLRPLPGRLNL 65 Query: 61 ILSSQPGTDD-----RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQK 109 +LS ++ ++ +AI + EI VIGG ++E LP+A++ Sbjct: 66 VLSRDLSYEERGKAKGAVVCSNLADAIDMARETAEDDGIDEICVIGGTALFEAALPRAKR 125 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LY+T ++AE EGD FP ++ + +E HDA ++ H + F IL+R Sbjct: 126 LYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR 174 >UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM Length = 180 Score = 202 bits (516), Expect = 2e-51, Method: Composition-based stats. Identities = 61/162 (37%), Positives = 92/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLI A + IG EN + W L DL FK+ T N ++MGR T+ESIGRPLP RKNI Sbjct: 15 MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNI 74 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 IL+ D+ + S + + P EI +IGG ++Y++FL A +LY+T +DA Sbjct: 75 ILTRDKDYKQDKCLIINSTQDILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDA 134 Query: 118 EV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E+ + D FP ++ ++ + + D +N + F + E+ Sbjct: 135 EMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK 176 >UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1IBP0_9CLOT Length = 161 Score = 202 bits (516), Expect = 2e-51, Method: Composition-based stats. Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 2/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MISLI A+ + IG +N + ++ DL +FKR T ++MG +T+ S+ RPLP R+N Sbjct: 1 MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPKRPLPNRRN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+L+++ + V S++E + E + GG +Y Q LP A KLY+THI E Sbjct: 61 IVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT+FP+ D+WE S H + + H + F I + Sbjct: 121 EADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK 158 >UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organisms RepID=A1TM51_ACIAC Length = 165 Score = 202 bits (516), Expect = 3e-51, Method: Composition-based stats. Identities = 60/164 (36%), Positives = 86/164 (52%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + LI A A + IG+ NAMPW+LP DLA FK+ TL V+MGR TW+S+ RPLPGR Sbjct: 3 LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRT 62 Query: 59 NIILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 NI+++ Q G D S+++A+ + V+GG ++Y Q LP A + +T I Sbjct: 63 NIVVTRQAGWHADGALSASSLEQAVELARPHGDTVWVMGGAQIYAQALPMADGVEVTEIH 122 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQN-SHSYCFEILERR 159 + E D P P +WE A + + + F RR Sbjct: 123 RDFEADAFAPVLGP-EWEETARTPVQTSAGSAALPFSFVSYRRR 165 >UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8X9J8_NAKMY Length = 292 Score = 202 bits (515), Expect = 3e-51, Method: Composition-based stats. Identities = 65/160 (40%), Positives = 90/160 (56%), Gaps = 10/160 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A + VIG MPW++PADL FKR T+ P++MGR T+ES+G LPGR++I+ Sbjct: 8 VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMG-LLPGRRSIV 66 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAA-CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++ P S+D AIA P +MV+GGG +Y Q LP+A +L +TH+D Sbjct: 67 ITRDPHWRAPGAEVADSLDRAIALGAQTDPVVMVVGGGEIYAQALPRADRLEITHLDLSA 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP +P W E D Y F RR Sbjct: 127 PGDTVFPAIDPALWAVTDREEADG-------YAFVTYRRR 159 >UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB Length = 164 Score = 201 bits (513), Expect = 6e-51, Method: Composition-based stats. Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+S+I A+A + VIG +N + W++ DL FK T K ++MGR T+ES+ LP RK+I Sbjct: 1 MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHI 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IL+ + V + DE + + E+ +IGGG +Y+Q LP + KLYLT I+ Sbjct: 61 ILTRDKNFKVNSECVEIIYDFDELLNKYKNSDDEVFIIGGGEIYKQLLPYSNKLYLTKIN 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GDT+FP +D++ + D ++ Y F L R Sbjct: 121 KDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR 162 >UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=B6INW3_RHOCS Length = 190 Score = 201 bits (513), Expect = 6e-51, Method: Composition-based stats. Identities = 68/166 (40%), Positives = 92/166 (55%), Gaps = 8/166 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + L+AA+A + VIG N +PW LP DL +FKR T+ KPV+MGR TWESIG +PLPGR NI Sbjct: 24 LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGAKPLPGRCNI 83 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+ G + AIA PE+ VIGG ++ + L A +LYLT Sbjct: 84 VLTRDTGFAPEGAIVCHGFLGAIAEARSVAARTGAPEVCVIGGESLFAEALRMADRLYLT 143 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AE GD FP ++ W E DA +S +Y L+R+ Sbjct: 144 EVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK 189 >UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0C500_HYPNA Length = 176 Score = 200 bits (509), Expect = 1e-50, Method: Composition-based stats. Identities = 71/165 (43%), Positives = 91/165 (55%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + LI A A +R+IG A+PW L D+A+FK T+ PVIMGR TWES RPLPGR+NI Sbjct: 7 LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGRENI 66 Query: 61 ILSSQPGTDDRVTWVKS-------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+ D V S AIAA E VIGG +Y LP A ++YLT Sbjct: 67 VLTRDWDYDAAEARVYSSFPAAMNAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLT 126 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +DAE+EGDT FP+ + W S H A N H++ L+R Sbjct: 127 EVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR 171 >UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobacterium RepID=C4L1C8_EXISA Length = 162 Score = 199 bits (507), Expect = 2e-50, Method: Composition-based stats. Identities = 55/159 (34%), Positives = 89/159 (55%), Gaps = 3/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS + A +R IG +N + W LP DL FK T V+MGR T+ESIG+ LP R+NI Sbjct: 1 MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNI 60 Query: 61 ILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++S + D+V +D +A E VIGG +YEQ +P ++Y T + A Sbjct: 61 VVTSDVSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASF 119 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT++P+ + +W + H D +++++ F+ ++ Sbjct: 120 EADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK 157 >UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA Length = 169 Score = 199 bits (506), Expect = 4e-50, Method: Composition-based stats. Identities = 51/172 (29%), Positives = 89/172 (51%), Gaps = 17/172 (9%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 +++ + A + +RVIG + +PW+LP D+ +F+ T +IMGR T++S GR LP R + Sbjct: 2 ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRYH 61 Query: 60 IILSSQPGTD-------DRVTWVKSVDEAIAACGDV-----PEIMVIGGGRVYEQFLPKA 107 I+++ P V +V S++EA+ + E+ +IGGG +Y+Q +P Sbjct: 62 IVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGDEVFIIGGGEIYKQAMPIT 121 Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 K+YLT I E GDT++P+ + + D + + F R+ Sbjct: 122 DKIYLTLIHREFPGDTYYPEIDEKVFTQTER----RDIETPIPFSFLTYLRK 169 >UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ Length = 161 Score = 198 bits (505), Expect = 4e-50, Method: Composition-based stats. Identities = 57/159 (35%), Positives = 90/159 (56%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A RVIG +N +PW+LP DL K+ T ++MGR T+ SIG+PLP R+N++ Sbjct: 3 LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVV 62 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L++Q + V + S+DE G + + GG ++E + + +Y+T ID + + Sbjct: 63 LTNQASFHHEGVDVINSLDEIKELSG---HVFIFGGQTLFEAMIDQVDDMYITVIDGKFQ 119 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP Y ++WE S D +N+ + F L RR Sbjct: 120 GDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR 158 >UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2 Length = 178 Score = 198 bits (505), Expect = 4e-50, Method: Composition-based stats. Identities = 55/165 (33%), Positives = 93/165 (56%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A++ + VIG + +PW LP+DL F+ T KP++MGR T+ESIGRPLPGR +++ Sbjct: 11 LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVV 70 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLT 113 +S+ P + V S+++ + + EIMVIGG R++ LP A+ L+LT Sbjct: 71 VSTDPAFTVPEGVLKGASLEDGLRLADEAADAMGADEIMVIGGARLFHDTLPLARTLHLT 130 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GD FP ++ W + + ++ ++ L R Sbjct: 131 QVHAAPDGDVFFPAFDEAQWREIARDGPIQGEKDEAAFTALTLVR 175 >UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc (Homalodisca coagulata) RepID=Q1LSS4_BAUCH Length = 165 Score = 198 bits (505), Expect = 5e-50, Method: Composition-based stats. Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+ VDR+IG++N MPW+L DL WFK++T NKPVIMGR T+++I +PL GR NI Sbjct: 2 IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61 Query: 61 ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +LS P D + WV + +A+ A G+V E+MVIGG ++Y F+ +A +LYLTHID Sbjct: 62 VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++GDT FP Y + W F ++H+ +N Y FEILER Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161 >UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017452A7 Length = 167 Score = 197 bits (503), Expect = 7e-50, Method: Composition-based stats. Identities = 59/161 (36%), Positives = 83/161 (51%), Gaps = 11/161 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGR 57 + IAA+A +RVIG + +PW+LP DL +FK+ T PV+MGR T+ESI G+PLP R Sbjct: 11 LIAIAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIVAALGKPLPNR 70 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +NI+LSS + V + + + +IGG ++YE LP +L LT ID Sbjct: 71 RNIVLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQ 130 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP +E D+ H + F R Sbjct: 131 PYEGDAFFPAFE-GDFSLREVLGHGEG------FEFRRYVR 164 >UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4 Length = 172 Score = 197 bits (503), Expect = 7e-50, Method: Composition-based stats. Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG++ +PW LPAD+A FK T+ P+IMGR T+ S+ R LP RK+I Sbjct: 1 MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHI 60 Query: 61 ILSSQPGT------DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYL 112 +L+ +D+VT + S+ E + ++ +GG +++ L + L Sbjct: 61 VLTHDQDLKKKYQDNDQVTIINSIAELGDYIQNHQGEKLCTVGGVSIFKALLDQVDVLEK 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T IDA E DT P+ + D ++ V E H+AD +N + Y F +R+ Sbjct: 121 TEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK 167 >UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA Length = 175 Score = 197 bits (503), Expect = 7e-50, Method: Composition-based stats. Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 9/162 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+ Sbjct: 17 VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76 Query: 62 LSSQPGT-DDRVTWVKSVD----EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++ Q G + S+D A + E+MVIGG ++ + LP A++LYLT I Sbjct: 77 VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT FP +E W V ++ D ++ F IL+R Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGDP----AFDFVILDR 174 >UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0AN20_MARMM Length = 173 Score = 197 bits (501), Expect = 1e-49, Method: Composition-based stats. Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + L+ A ++ VIG++ +PW L +DL FK T KP+IMGR TWES+ RPLPGR NI Sbjct: 8 LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPRRPLPGRLNI 67 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +++ Q G + + EA+ A V E+ VIGG ++Y L +A +LYLT Sbjct: 68 VVTRQDGYVAEGGHVAGDLGEAMDAAFMRADADGVDEVCVIGGAQIYAATLERADRLYLT 127 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++A EG+T P+ + W E + A + H++ +L+R Sbjct: 128 EVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR 172 >UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1 Length = 167 Score = 195 bits (497), Expect = 3e-49, Method: Composition-based stats. Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS + A IG + +PW LPADLA FK T+ P++MG+ T++S LP R++I Sbjct: 1 MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHI 60 Query: 61 ILSSQPGTDDR------VTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYL 112 +L+ +++ V + S+DE + + E+ VIGG ++ L K KLY Sbjct: 61 VLTHDTNLEEKYKDNPQVEIMNSIDELTSWLDENQFQEVSVIGGAMLFNLLLNKVDKLYK 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I +E GDT P D+++ V + D +N + Y F ER+ Sbjct: 121 TEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK 167 >UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT Length = 169 Score = 195 bits (497), Expect = 4e-49, Method: Composition-based stats. Identities = 56/162 (34%), Positives = 87/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M+ I A ++G + +PW LP DL +FK T+ + ++MGR T+E +G R LPGR+ Sbjct: 1 MLIYIWAQDERGLVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGSRLLPGRQT 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IIL++ V +++E I +I V GG +VY + LY T I A Sbjct: 61 IILTTSSDYIVPGAEVVTNIEE-IVEDSRHEDIYVCGGAQVYNLLKNHVELLYCTRIHAS 119 Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD++FP ++ D+ V S + D +N + + FEI ER+ Sbjct: 120 FEGDSYFPTEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK 161 >UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA Length = 163 Score = 195 bits (496), Expect = 4e-49, Method: Composition-based stats. Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+ + A + RVIG+ +PW+LPAD+ +FK T ++ G T+ S RPLP RKNI Sbjct: 1 MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNI 60 Query: 61 ILSSQPGT--DDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++S QP T + V+ + S+ A AA +I V+GG +++ L LY T ID Sbjct: 61 VVSHQPATAFPENVSVLHSLPAVRAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 A +GDT P + + + + + +N + + FE +R Sbjct: 121 AGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR 162 >UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9ECC1_MACCJ Length = 164 Score = 195 bits (496), Expect = 5e-49, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 93/160 (58%), Gaps = 5/160 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA++ + VIG + +PW +P + FK T+ K VIMGR T+ESIG+PLP RK I Sbjct: 2 IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTI 61 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + + V+S++ A EI + GGG +Y++ LP A ++YLT I+ E Sbjct: 62 IISKSKDINYNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEY 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EG+ FP + D++E + + + Y + ER+ Sbjct: 122 EGNIFFPMFNKDEFEITYQQK----VEGFIPYTYFTYERK 157 >UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5 Length = 164 Score = 195 bits (496), Expect = 5e-49, Method: Composition-based stats. Identities = 68/162 (41%), Positives = 95/162 (58%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A + IG +N +PW LP DL FK TL KP++MGR T +S+GR LPGR N++ Sbjct: 3 LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ D + V SV++AI E+ VIGGG VY + +A L +T +D Sbjct: 63 LTRSGQVPFDGMQAVASVEQAIERAVQEGAQELCVIGGGEVYRLTMERADLLAVTEVDTA 122 Query: 119 VEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V+G DTHFP +P W E H ADA+++H++ F ERR Sbjct: 123 VDGADTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR 164 >UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN Length = 170 Score = 194 bits (495), Expect = 6e-49, Method: Composition-based stats. Identities = 60/163 (36%), Positives = 92/163 (56%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL--NKPVIMGRHTWESIGRPLPGRK 58 M+S++ A+ + VIG ++++PW+LP DL +FK+ TL +K +IMGR T++S+ LPGRK Sbjct: 1 MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLTESKTMIMGRKTFQSLKALLPGRK 60 Query: 59 NIILSSQPGT---DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +IIL+ D V + +D D E VIGGG ++ LP +K+Y+T I Sbjct: 61 HIILTKNKNFNMKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP+ DW + D +N +++ F IL R Sbjct: 121 HHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR 163 >UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC Length = 164 Score = 194 bits (495), Expect = 6e-49, Method: Composition-based stats. Identities = 56/160 (35%), Positives = 83/160 (51%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +S+IA+L + IG EN + LPADL F++ TL +IMGR T++S+ LP R+NI Sbjct: 3 LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPNGILPDRENI 62 Query: 61 ILSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S S+D A++ + E+ +IGG ++Y+Q LP LYLT + A Sbjct: 63 IISRNGSLAIKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATF 122 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E D FP +W E A+ +N + F ER Sbjct: 123 PEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER 162 >UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SJK6_9BACT Length = 156 Score = 194 bits (494), Expect = 8e-49, Method: Composition-based stats. Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 8/157 (5%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 +LI A+ DRVIG N MPW+LP DL FK T + MGR T+ESIGRPLP R+N ++ Sbjct: 4 ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVI 63 Query: 63 SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 + D SV E I A + + + IGGG++Y + ++++++I +G Sbjct: 64 TRSGKEYDGCRVFGSVQECIKAAEEYDKTLFFIGGGQIYSDAVDMVDEMHISYIKENYDG 123 Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 DT FP+++ W+ +E + + ++ R Sbjct: 124 DTFFPEFDESRWKVTETEEYG-------DFIYKKFVR 153 >UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105 RepID=A6GQA5_9BURK Length = 188 Score = 194 bits (493), Expect = 1e-48, Method: Composition-based stats. Identities = 57/183 (31%), Positives = 93/183 (50%), Gaps = 26/183 (14%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++AA+A + +IG+ N++PW+LP DLA+FK+ TL PV+MGR T+ESI RPLPGR N++ Sbjct: 3 VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVV 62 Query: 62 LSSQPGTDD------------------------RVTWVKSVDEAIAACGDVPEIMVIGGG 97 LSS ++ ++ +A+ ++ +IGG Sbjct: 63 LSSNSDWKPAPGKDGTPRSVITHPAALPEGSATQIATATNLPDALNWLSSFEQVFLIGGS 122 Query: 98 RVYEQFLPK--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155 +YEQ L + +L LT I EGD FP ++ + V + A + + + F Sbjct: 123 NLYEQALAQGLVDELILTEIHQSFEGDASFPQWDRQQFREVDRITNTATPERAWGFDFVK 182 Query: 156 LER 158 + Sbjct: 183 YAK 185 >UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacteriaceae RepID=B9LR90_HALLT Length = 194 Score = 194 bits (493), Expect = 1e-48, Method: Composition-based stats. Identities = 66/171 (38%), Positives = 96/171 (56%), Gaps = 14/171 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWES----IGRPLPGR 57 + L+AA+A +RVIG + MPW+ PADLA FKR T PVI+GR T+ES IG PLP R Sbjct: 21 LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESIADRIGGPLPDR 80 Query: 58 KNIIL-SSQPGTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKL 110 +++L + + +DEA+ G V ++ VIGG VYEQFL +A ++ Sbjct: 81 TSVVLTTRDLDLPEGAVVANDLDEAVDLAGADAADRGVDDVYVIGGATVYEQFLDRADRM 140 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQ---NSHSYCFEILER 158 LT + + +GDT FPD++ ++W E AD + + + F ER Sbjct: 141 VLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGGEADALAFVTYER 191 >UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=A0Z2N0_9GAMM Length = 184 Score = 193 bits (492), Expect = 1e-48, Method: Composition-based stats. Identities = 59/164 (35%), Positives = 88/164 (53%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+ A++ + VIG NA+PW+LP DL FK+ T+ P++MGR T+ES+GRPLPGR N++ Sbjct: 13 VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLV 72 Query: 62 LSSQPGTD-DRVTWVKSVDE------AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 L+ VT SVD+ A A + V+GG +Y LP+A ++ LT Sbjct: 73 LTRDSTWQAPGVTIFSSVDKALALAEAQALIDGASAVCVVGGAEIYRLCLPRADRILLTL 132 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +V GD F + W+ E A+NSH + R Sbjct: 133 VHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDFSVVEFVR 176 >UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA Length = 161 Score = 193 bits (491), Expect = 2e-48, Method: Composition-based stats. Identities = 57/161 (35%), Positives = 91/161 (56%), Gaps = 4/161 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS+I A + IG + ++PW++P D+A+FK+ T V+MGR T++SIG+ LP RKNI Sbjct: 1 MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +LS P + D V V S+ E AI + +IGG +Y L +A +L +T I Sbjct: 61 VLSHHPTSLPDSVVGVGSLSELQAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQK 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + + + PD ++++ S H++ +N +Y FE R Sbjct: 121 DYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFETWIR 160 >UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY Length = 170 Score = 192 bits (489), Expect = 4e-48, Method: Composition-based stats. Identities = 50/164 (30%), Positives = 88/164 (53%), Gaps = 6/164 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I I A + +IG + +PW+LPADLA FK+ T ++MGR T++ +G R LP R I Sbjct: 5 IVAIWAQDENGLIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGKRALPNRHTI 64 Query: 61 ILSSQPGTD---DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116 +L++ +R+T + SV++ + + + VIGGG+++ F P + L +T I Sbjct: 65 VLTTDKTYQLESERITILHSVEDVLDWYNKQEQTLFVIGGGQIFTAFAPYIETLIVTDIH 124 Query: 117 AEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + GD +FP + + ++ + D +N + + + ERR Sbjct: 125 GQFNGDVYFPKAFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR 168 >UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B2267 Length = 178 Score = 192 bits (488), Expect = 4e-48, Method: Composition-based stats. Identities = 65/162 (40%), Positives = 88/162 (54%), Gaps = 8/162 (4%) Query: 3 SLIAALAVDRVIGMENAMPW--NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 ++I A +R IG +PW +LPADLA FK+ T +IMG T+ESIG RPL RKN Sbjct: 17 AIIVAYDRNRAIGRGGDLPWGRSLPADLAHFKQLTKGGGIIMGHRTFESIGSRPLLERKN 76 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 I++SS+P + V V + A+A +IGG RVY L P+ +Y T IDA Sbjct: 77 IVISSRPTDSEGVLTVMDLPSALALSHYST--FIIGGARVYADALETPEIDTIYATEIDA 134 Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 G DT FP+ + W+ H ADA N + + F I +R Sbjct: 135 SFPGADTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR 176 >UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus aureus RepID=DYR_STAAC Length = 159 Score = 192 bits (488), Expect = 5e-48, Method: Composition-based stats. Identities = 55/159 (34%), Positives = 92/159 (57%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A + RVIG EN +PW+LP DL K+ + ++MGR T+ESIG+PLP R+N++ Sbjct: 3 LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+S + + V + S+++ G + + GG ++E+ + K +Y+T I+ + Sbjct: 63 LTSDTSFNVEGVDVIHSIEDIYQLPG---HVFIFGGQTLFEEMIDKVDDMYITVIEGKFR 119 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP Y +DWE S D +N+ + F L R+ Sbjct: 120 GDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 158 >UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37DF3 Length = 160 Score = 191 bits (487), Expect = 5e-48, Method: Composition-based stats. Identities = 60/161 (37%), Positives = 91/161 (56%), Gaps = 8/161 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS+IAA A + VIG +PW++P D+A+F+R T VIMGR T+E IGRPLPGR N+ Sbjct: 1 MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNV 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++S++ T + S+ EA+ G+ I + GG VY + L A ++YLT +D Sbjct: 61 VVSAKMQTAPEGTALAHSLAEAVEIAGNSGRENIFLCGGAAVYREGLAFADRIYLTILDK 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E GD +FP++ ++ E D+ F I ++ Sbjct: 121 EYSGDVYFPEFSEKEFRLTSYERCDSA-----PITFCIYDK 156 >UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui RepID=DYR2_HALMA Length = 167 Score = 191 bits (486), Expect = 6e-48, Method: Composition-based stats. Identities = 68/164 (41%), Positives = 86/164 (52%), Gaps = 14/164 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR----PLPGR 57 +SLIAA+A + VIG +PW P DL FK T+ PVIMGR T+ESI R PLP R Sbjct: 5 LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRDLDGPLPER 64 Query: 58 KNIILSSQP-GTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTH 114 NI+L++ P D VT V S A+A D VIGG VYEQFLP+A +L LT Sbjct: 65 LNIVLTTTPHQLPDSVTAVTSTTAAVAEAADSDASTTYVIGGATVYEQFLPQADELILTE 124 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GDT FP + +W + H + R Sbjct: 125 LAAAFDGDTVFPTVDWSNWTEMERTTHSE-------FAIVRYTR 161 >UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PCZ0_9BACT Length = 179 Score = 190 bits (485), Expect = 9e-48, Method: Composition-based stats. Identities = 59/181 (32%), Positives = 90/181 (49%), Gaps = 25/181 (13%) Query: 1 MISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58 M+S+IA ++ R IG +N + + +P+D+ F+ T +IMGR T+ES+ LP R+ Sbjct: 1 MLSIIACISKVHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPNGALPNRR 60 Query: 59 NIILSSQPGTDDRVTWVKSVDEAIAACGDV-------------------PEIMVIGGGRV 99 NI++S S++EA+AA + E +IGG + Sbjct: 61 NIVISKTREQITGCEVYTSLEEALAARKEEAARKEEVGNKETVGSKEASDECFIIGGASI 120 Query: 100 YEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 YEQ LP A KLYLT ++ E E DT FP+ P +WE E + +N + F L R Sbjct: 121 YEQALPFADKLYLTIVEKEPEHADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLTLYR 177 Query: 159 R 159 + Sbjct: 178 K 178 >UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS Length = 166 Score = 190 bits (485), Expect = 1e-47, Method: Composition-based stats. Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+ + A + +IG + +PW LP DLA FKR T+N+ VIMGR T++S+ +PLPGR+N Sbjct: 1 MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPKKPLPGRQN 60 Query: 60 IILSSQPGT--DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHI 115 I+++ Q G V + + + P ++ +IGG +++ F LY+T I Sbjct: 61 IVITRQSGLTVAKDVLVFNERTQLLDYQKEHPMQKLFIIGGADIFKLFAADVDYLYVTKI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GD + P + ++ + + D +N + + FEI +R Sbjct: 121 AEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR 163 >UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB Length = 306 Score = 190 bits (484), Expect = 1e-47, Method: Composition-based stats. Identities = 59/158 (37%), Positives = 91/158 (57%), Gaps = 4/158 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS IAAL+ +RVIG + +PW++P+DL F+ T+ VIMGR T+ESIG PL GR+NI Sbjct: 2 IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNI 61 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +L+ + + ++V AIAA E+ + GGG V+++ LP Q+LYLT + Sbjct: 62 VLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYR 121 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD P+ P+ + + E + F +LE+ Sbjct: 122 GDAFLPEL-PEGFVELHREEFP---DTTPPSSFVVLEK 155 >UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGC7_LIBAP Length = 176 Score = 190 bits (484), Expect = 1e-47, Method: Composition-based stats. Identities = 58/164 (35%), Positives = 85/164 (51%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LIAA+ + VIG MPW + +DL FK T PV+MG T++SIGR LPGR NII Sbjct: 6 IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNII 65 Query: 62 LSSQ----PGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHI 115 ++ + S+ +++ +I +IGGG +Y Q + A LY+THI Sbjct: 66 ITRDNTRRASVNPEAVLASSILDSLDLASKTGSKKIFIIGGGEIYAQTISLAHTLYITHI 125 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFH-DADAQNSHSYCFEILER 158 + E+EGD FP + + W+ E A + + F I +R Sbjct: 126 EKEIEGDVFFPSIDSNIWKKQEKEIITSAGEGDDYPTRFVIYDR 169 >UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT Length = 161 Score = 190 bits (483), Expect = 2e-47, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 80/160 (50%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +++IAA+A +R IG N M + + DL FK+ T VIMGR T+ S+ + LP R+NI Sbjct: 3 LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKGALPNRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119 +LS S+DEA+ + +IGG +Y++ L A +LYLT I D Sbjct: 63 VLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIADTPA 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D FP Y W E H A ++ Y F R+ Sbjct: 123 QADVFFPPYNDGTWRVESREEHPA-TDDTPPYSFVNYVRK 161 >UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MBL2_9PORP Length = 173 Score = 190 bits (483), Expect = 2e-47, Method: Composition-based stats. Identities = 63/163 (38%), Positives = 88/163 (53%), Gaps = 6/163 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I +I A A DR IG + MPW L DL K T VIMGRHTW+SIG RPLP R NI Sbjct: 3 IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGARPLPNRYNI 62 Query: 61 ILSSQ-PGTDDRVTWVKS-VDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++S P D +V S +++A+ C + ++GGG +Y+ LP A L LT +D Sbjct: 63 VVSRTLPEGDAETHYVASTLEQALQHCQQAGYDRVYIMGGGVLYKSGLPYATHLNLTMVD 122 Query: 117 AEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V + DTHFP+ +W + + AD +N + + +R Sbjct: 123 TVVPDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR 165 >UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9 Length = 198 Score = 189 bits (482), Expect = 2e-47, Method: Composition-based stats. Identities = 59/165 (35%), Positives = 89/165 (53%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++++AALA +RVIG+ AMPW+LP D F+ T KP++MGR T+ESIGR LPGR+ I+ Sbjct: 25 LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIV 84 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIM----VI--GGGRVYEQFLPKAQKLYLTH 114 L+ V ++ A+ D IM +I GGG ++ LP+ ++L LT Sbjct: 85 LTRDETFAAPGVLVAHDLEGALGLAHDWARIMGAKTIILVGGGELFAALLPRVERLELTL 144 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ +GDT FP + WE ++ SY F R+ Sbjct: 145 VEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK 189 >UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA Length = 171 Score = 189 bits (482), Expect = 2e-47, Method: Composition-based stats. Identities = 60/167 (35%), Positives = 86/167 (51%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI I A D IG + +PW+LPADL FK T N ++MGR T+ES LP R++I Sbjct: 3 MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHI 62 Query: 61 ILSSQP------GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYL 112 ILS+ P + V + E D E I +IGG RV+E+F+ + + Sbjct: 63 ILSTSPTLQRKYQNNAHVKIFSQLKELKNWIKDHSEQTIDIIGGARVFEEFMDEVDMIEK 122 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I +GDT P +D+E + ++ H AD +N +Y F ER+ Sbjct: 123 TKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK 169 >UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13 RepID=B6BUF2_9PROT Length = 148 Score = 189 bits (482), Expect = 2e-47, Method: Composition-based stats. Identities = 46/152 (30%), Positives = 78/152 (51%), Gaps = 6/152 (3%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 ++ + VIG++N++PW+L DL FK T ++MGR T+ESIG+PLP R N +L+ Sbjct: 1 MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRNSD 60 Query: 68 TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 D V + S+++ + +IGGG +Y Q + +L +T I E+ GD FP Sbjct: 61 LKIDGVHVISSLND---ISDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFP 117 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + W V + + +N + + + Sbjct: 118 MIDASVWSLV--DQSEKLNENDIEFSYLTYRK 147 >UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D3H9_WIGBR Length = 162 Score = 189 bits (481), Expect = 3e-47, Method: Composition-based stats. Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A + ++VIG + +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL R NI+ Sbjct: 3 ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + + K+ +A+ + E+M+IGG ++Y+ FLPKA KLYLT I+AE+ Sbjct: 63 LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 G+ FP Y W F ++ ++D +N +S F I + Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161 >UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XJM4_9BACT Length = 156 Score = 189 bits (480), Expect = 4e-47, Method: Composition-based stats. Identities = 58/128 (45%), Positives = 78/128 (60%), Gaps = 1/128 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IAA++ +RVIG N +PW+LP D WFK+ T + V+MGR T+ESIGRPLP R+ I+ Sbjct: 4 FKAIAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIV 63 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 LS P V + + E I+ + EI + GG ++YEQ LP LYLT + VEG Sbjct: 64 LSRGPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEG 122 Query: 122 DTHFPDYE 129 D FP +E Sbjct: 123 DAFFPTFE 130 >UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614 RepID=A1SJ32_NOCSJ Length = 160 Score = 188 bits (479), Expect = 4e-47, Method: Composition-based stats. Identities = 54/144 (37%), Positives = 82/144 (56%), Gaps = 2/144 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A + VIG +PW LP + FK T ++MGR T++SIGRPLPGR I+ Sbjct: 8 VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIV 67 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ P + + V + A+A + E+MV GGG+VY LP A + L+ +D E Sbjct: 68 LTRSPDWSAEGVHVAHDLPAALALADTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEP 127 Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143 +GD +P+++ +W E HD Sbjct: 128 QGDAFYPEFDRSEWRETAREQHDG 151 >UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD Length = 337 Score = 188 bits (478), Expect = 7e-47, Method: Composition-based stats. Identities = 55/177 (31%), Positives = 83/177 (46%), Gaps = 28/177 (15%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A+A + IG + +PW+LP DL FK T+ ++MGR T+ES RPLPGR++++ Sbjct: 168 LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVV 227 Query: 62 LSSQPGT----------------DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLP 105 ++S P D V +S EA+ GD E+ V+GG V+ LP Sbjct: 228 MTSDPTWLPGGPAVEGDPASGARFDEVLVARSWAEALLMAGDG-EVFVVGGAGVFADALP 286 Query: 106 KAQKLYLTHIDAEV-EGDTHFP---DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 A +L LT +D + DT FP +P W + Y R Sbjct: 287 VADRLVLTEVDQSPQDADTFFPITWPVDPTVWHESSRTPGEG-------YAIVEYRR 336 >UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN Length = 168 Score = 187 bits (477), Expect = 8e-47, Method: Composition-based stats. Identities = 57/162 (35%), Positives = 94/162 (58%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60 I I A + VIG EN +PW+LPA+L FK TLN ++MGR T++ +GR LP R+ + Sbjct: 5 IVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IL+ P D V + V + + + +IGG ++++ F P ++ +THI A Sbjct: 65 ILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHAR 124 Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 VEGDT+FP + + +E+V S+F+ D +N + + + +R+ Sbjct: 125 VEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK 166 >UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perfringens SM101 RepID=Q0SWS9_CLOPS Length = 161 Score = 187 bits (475), Expect = 1e-46, Method: Composition-based stats. Identities = 57/161 (35%), Positives = 93/161 (57%), Gaps = 6/161 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M S+I A +++ +IG+ N +PWN+P+DL FK T+ K ++MGR T+ES+ LPGR ++ Sbjct: 1 MFSIIVAKSINNIIGVNNKIPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+++ V +D+ I+ D EI VIGGG++Y +FL A KLY+T + Sbjct: 61 VLTTKKDFSYNHKDVIIYNDLDKLISEYKDSMEEIFVIGGGKIYSEFLKYASKLYITEVL 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 E +GDT+FP + W + +N+ + + I E Sbjct: 121 KEYKGDTYFPKVDYSKWIKTYE--SSIYEENATKFKYVIYE 159 >UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis RepID=C8WCM1_ZYMMN Length = 165 Score = 186 bits (474), Expect = 2e-46, Method: Composition-based stats. Identities = 57/160 (35%), Positives = 86/160 (53%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LI A A + VIG +N MPW++ ADL FK TL P+IMGR T+ES+ LP R +I+ Sbjct: 7 IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIV 66 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ + V ++EAI A +I VIGG +++QF KA ++ LT I + Sbjct: 67 LTHNHHWQAEGAEVVCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELTEIYRDY 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT + + + V E A+ + ++ F+ R+ Sbjct: 127 SGDTFVDLPDMNHFSLVGQEDFKAEGECP-AFSFKSFLRK 165 >UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PWR8_9BACT Length = 163 Score = 186 bits (473), Expect = 2e-46, Method: Composition-based stats. Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+I A+A +R IG N + ++LP D+ FK T +IMGRHT++S+ L R+NI Sbjct: 3 ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLPNGALLHRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 ++S S+++AIA+C E+ +IGG +Y Q L A ++YLT +D Sbjct: 63 VVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVDDTPT 122 Query: 120 EGDTHFPDYEPDDWESVFSEFH 141 + DT FP+ + W+ E H Sbjct: 123 QFDTVFPEIDMSHWQETKKEKH 144 >UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2 Length = 167 Score = 185 bits (472), Expect = 3e-46, Method: Composition-based stats. Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60 I I A A + VIG + MPW+LPA+LA FK+ T+ ++MGR T++ + R LPGR+ + Sbjct: 5 IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRCLPGRETL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IL+ D + VT V SV+EA+A ++ + GG VY+ F L T I+A+ Sbjct: 65 ILTRDKDFDCEEVTTVTSVEEALAWFEQQDKDLYIAGGASVYKAFDGHYDVLIKTTIEAD 124 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +EGDT+FP + ++ V + +N++ + E+ Sbjct: 125 LEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK 164 >UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate reductasetype III) n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3 Length = 181 Score = 185 bits (471), Expect = 4e-46, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 86/160 (53%), Gaps = 9/160 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A+ + IG NA+PW++ ADL FK T VIMGR T ES+GR LP R N +++ Sbjct: 11 VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITR 70 Query: 65 QPGTD-DRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 D V S+++A+ A + + +IGGG +++Q L A +L LTH+D Sbjct: 71 DINWHFDGVKIAYSIEDALNAALEDAKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDL 130 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 +V+GD H+P P ++ SE D ++ S+ F + Sbjct: 131 DVQGDAHYPTI-PSEFHKTASEQ-QVDEKSGTSFEFATYK 168 >UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYS7_9BACL Length = 163 Score = 185 bits (470), Expect = 5e-46, Method: Composition-based stats. Identities = 51/160 (31%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+SLI A ++ IG EN +PW L D+ K T N+ +IMGR T +SIGR LP R N Sbjct: 1 MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINR 60 Query: 61 ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ + + ++ D++I + + + GGG +Y ++ K ++++T ++ V Sbjct: 61 VLTRDKDSLSHYSNIEVYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIV 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E DT FP+++ ++WE + E D N + F +R+ Sbjct: 121 EADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK 160 >UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD Length = 162 Score = 184 bits (468), Expect = 9e-46, Method: Composition-based stats. Identities = 58/158 (36%), Positives = 86/158 (54%), Gaps = 4/158 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 ++LI A ++ IG +N +PW++ AD+ FK T P+IMGR T+ S+G +PLP R+NI Sbjct: 4 LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGNKPLPKRENI 63 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+S+ + V V S+ + E VIGG +Y+Q LP A KL T I+ ++ Sbjct: 64 VLTSRNIDAEGVEVVHSLAALKEYLKANPNEYFVIGGATIYQQLLPMATKLTRTVINKQI 123 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 GDT P + D W V ++ D Q FE E Sbjct: 124 VGDTKMPTIDYDRWHLVNHNNYEKDDQ--LICRFEEWE 159 >UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2 Length = 194 Score = 184 bits (468), Expect = 9e-46, Method: Composition-based stats. Identities = 60/170 (35%), Positives = 84/170 (49%), Gaps = 14/170 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + L+ A VIG + MPW+LP D+ F R T PVIMGR TW S RPLPGR Sbjct: 23 VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPGRT 82 Query: 59 NIILSSQPGTDD-----RVTWVKSVDEAI---AACGDVPEIMVIGGGRVYEQFLPKAQKL 110 NI+++ Q G D VKS+D+A+ + V+GGG ++ Q L A Sbjct: 83 NIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIADVA 142 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158 +T ID+E +GDT+ P+ +W+ SE + Y F + R Sbjct: 143 VVTFIDSETDGDTYAPELGY-EWKLAASEPATGWLTSATGTRYRFTMWRR 191 >UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD Length = 195 Score = 184 bits (468), Expect = 1e-45, Method: Composition-based stats. Identities = 66/164 (40%), Positives = 89/164 (54%), Gaps = 18/164 (10%) Query: 6 AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNII 61 AA+A + +IG + MPW++PADL FKR T+ PVI+GR T+E+I G P PGR +I+ Sbjct: 37 AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIIGALGEPFPGRTSIV 96 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPKAQKLYLTH 114 LSSQ V V S+ AI + V GGG VYEQFLP A +L LT Sbjct: 97 LSSQSRDVPADVILVHSITSAIREASKNARERGVGTVYVAGGGGVYEQFLPLADRLRLTE 156 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + E EGDT FP ++ W+ E ++ ++ F ER Sbjct: 157 LHDEYEGDTKFPSWDDTVWQETTREKNE-------TFDFVTYER 193 >UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD Length = 171 Score = 184 bits (467), Expect = 1e-45, Method: Composition-based stats. Identities = 64/163 (39%), Positives = 83/163 (50%), Gaps = 11/163 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MI L+ A + + VIG +PW +P DLA F T V+MGR TWES+ RPLPGR Sbjct: 1 MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60 Query: 58 KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +N++LS PG + V + A+A GD + VIGG VY L A L +T +D Sbjct: 61 RNLVLSRDPGYAAEGAEVVHDLPGALAGAGD---VWVIGGSAVYRAALEHADVLVVTEVD 117 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHD-ADAQNSHSYCFEILER 158 VEGDT P+ P WE V E D A + + R Sbjct: 118 LVVEGDTRAPEVGPG-WERV--EVGDWATSTGGPRFRIGTWRR 157 >UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica RepID=Q7UIC9_RHOBA Length = 195 Score = 184 bits (467), Expect = 1e-45, Method: Composition-based stats. Identities = 58/159 (36%), Positives = 85/159 (53%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ + A + VIG + MPW L +DL FK+ T+ +IMGR T+ESIGR LPGR+ I+ Sbjct: 31 ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIV 90 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ Q EAIA D I V+GGG++Y+Q+ P +L+ T + A V Sbjct: 91 LTRQGHWQFPGTQTASGKSEAIALAADR-RIFVVGGGQIYQQWFPLCTELWWTRVWANVS 149 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT D D++E V A++ + + + RR Sbjct: 150 GDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR 187 >UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LGH8_RHOVA Length = 178 Score = 184 bits (467), Expect = 1e-45, Method: Composition-based stats. Identities = 53/166 (31%), Positives = 86/166 (51%), Gaps = 9/166 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A A + VIG E +PW L +DL F+R T+ P+IMGR T+ SIG+PL GR ++I Sbjct: 9 LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVI 68 Query: 62 LSSQPGT---DDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 ++ + V S+ +A+ V E VIGG ++ LP A +++L Sbjct: 69 VTRDAASVSPQPGVFVATSIKDALDIARARAAERRVAEAFVIGGAEIFALALPYADRIHL 128 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A GD ++ ++W+ V E A+ + S +LER Sbjct: 129 ARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER 174 >UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia pennsylvanicus str. BPEN RepID=Q494F1_BLOPB Length = 164 Score = 183 bits (465), Expect = 2e-45, Method: Composition-based stats. Identities = 76/162 (46%), Positives = 106/162 (65%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 +ISLIAAL + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL R N Sbjct: 2 IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61 Query: 60 IILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA- 117 I+LS + V +++DEA++ D E+MVIGG +Y FLP+AQ+LYLT+I Sbjct: 62 IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121 Query: 118 -EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E++GD FPDY+ +W+S+F+ F+ F ILER Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163 >UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3 Length = 167 Score = 183 bits (465), Expect = 2e-45, Method: Composition-based stats. Identities = 54/158 (34%), Positives = 83/158 (52%), Gaps = 4/158 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ I A IG +N MPW+L ADL FK T PVIMG++T+ S+GRPLP R NI+ Sbjct: 4 IAFIWAEDEAGWIGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIV 63 Query: 62 LSSQPGTDDRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q + VT V V+ + +A G+ E+ +IGG ++ + A LY T ++ + Sbjct: 64 VTRQTTPIEGVTLVNGVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGD 123 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 GD + W+ V +E H ++ + FE Sbjct: 124 HHGDVKMAPIDYRTWQKV-AERHLQATESDPACTFEKW 160 >UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA Length = 181 Score = 183 bits (465), Expect = 2e-45, Method: Composition-based stats. Identities = 64/169 (37%), Positives = 91/169 (53%), Gaps = 12/169 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 +I +I A A + VIG + MPW+LP D F+R T VIMGR TWES+ RPLPGR Sbjct: 7 VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPEPFRPLPGR 66 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVP---EIMVIGGGRVYEQ--FLPKAQKLY 111 +N++++S P + S+ A+AA P ++ +IGGG VY + FL A Sbjct: 67 RNLVITSDPAWSAPGAVRSSSILNALAAAAGQPGSDQVWIIGGGMVYREALFLRAANTAV 126 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHD--ADAQNSHSYCFEILER 158 +T I ++++GDT+ P+ PD WE +E A N Y E R Sbjct: 127 ITLIASDIDGDTYAPELGPD-WEMASAEPGVGWTTAANGTRYRIETWTR 174 >UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU Length = 156 Score = 182 bits (464), Expect = 3e-45, Method: Composition-based stats. Identities = 58/162 (35%), Positives = 95/162 (58%), Gaps = 11/162 (6%) Query: 1 MISLIAALAVDRVIGME---NAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57 MI++I A D +IG + N MPWN+P DL FK TLNK ++MG T+++IGRPLP R Sbjct: 1 MINIIVATDEDLLIGKKDSRNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNR 60 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 K I++S +P D+RV S++E I ++ + GG +Y+Q LP A +L ++ I Sbjct: 61 KTIVVSFEPFEDERVEVRSSLEEVIEEYRSSGEDLFISGGASIYKQCLPIADQLLISRIP 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EG+T+FP+++ ++ V + + ++ E +R Sbjct: 121 GKHEGETYFPNFDEYGYKLVAQKPFE-------TFTLETYKR 155 >UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFCBD Length = 161 Score = 182 bits (464), Expect = 3e-45, Method: Composition-based stats. Identities = 56/154 (36%), Positives = 94/154 (61%), Gaps = 4/154 (2%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 +I A++ + IG+ N +PWN+ D+ +F++ T K VIMGR T+ SIGRPLP R+NI+L+ Sbjct: 1 MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLT 60 Query: 64 SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122 + V V + EA+ + + VIGGG++YE F+P A++LY+T +D +++GD Sbjct: 61 TNTDLKIAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDIDGD 119 Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 FP+Y + + V + A+ + ++Y F Sbjct: 120 AAFPEY-RNKFVCVETIEKSAN-DSKYNYRFTKW 151 >UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perfringens RepID=Q0TV23_CLOP1 Length = 161 Score = 182 bits (463), Expect = 3e-45, Method: Composition-based stats. Identities = 54/162 (33%), Positives = 91/162 (56%), Gaps = 6/162 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M S+I A +++ +IG+ N MPWN+P+DL FK T+ K ++MGR T+ES+ LPGR ++ Sbjct: 1 MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+++ V +++ I+ D EI VIGGG++Y + L KLY+T + Sbjct: 61 VLTTKKDFSYNHKDVIIYNDLNKLISEYKDSMEEIFVIGGGKIYSELLKYTSKLYITEVL 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E +GDT+FP + W + +N + + F ++ Sbjct: 121 KEYKGDTYFPKVDYYKWIKTYESSIH--EENGNKFKFFNYKK 160 >UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage phiNIT1 RepID=D0VXF2_9VIRU Length = 168 Score = 182 bits (462), Expect = 4e-45, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 91/161 (56%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LIAA+ ++ IG +N + W++ D+ WF++ T NK V+MGR T+ESIG+PL GR N++ Sbjct: 3 VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVV 62 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ D V ++++ + EIMVIGG +Y QF P A ++YLT ++ Sbjct: 63 LTHNKEYDPHPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTY 122 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E D FP+++ W F + D Y F + ++R Sbjct: 123 EEADAFFPEFDCSIWNRYF--YQDGSEDIGIKYNFSVYKKR 161 >UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP Length = 164 Score = 182 bits (462), Expect = 5e-45, Method: Composition-based stats. Identities = 71/160 (44%), Positives = 106/160 (66%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+ Sbjct: 3 ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62 Query: 62 LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ Q + V +V S+ +AI + EIM+IGG +Y Q L A KLY+THI+ + Sbjct: 63 LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADA--QNSHSYCFEILER 158 GDT+FP Y+ W+ +F + +NS F+IL++ Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162 >UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP Length = 173 Score = 181 bits (461), Expect = 5e-45, Method: Composition-based stats. Identities = 59/172 (34%), Positives = 90/172 (52%), Gaps = 16/172 (9%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LI+A++ + VIG N + W+LP DL FK T + V+MGR T+ESIG+ LPGR+NII Sbjct: 3 IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNII 62 Query: 62 LS--------SQPGTDDR------VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKA 107 L+ S T+++ S+ + + +I VIGG ++Y + KA Sbjct: 63 LTKKNKIHFFSSTNTNNKTNPRGTFEVYSSLKQIYDL--NYKKIFVIGGEKIYTSTIDKA 120 Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + LT I + GD FP W+ + FH+ D + ++Y F ER+ Sbjct: 121 HIIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK 172 >UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis RepID=Q3F0Y0_BACTI Length = 172 Score = 180 bits (459), Expect = 9e-45, Method: Composition-based stats. Identities = 57/171 (33%), Positives = 82/171 (47%), Gaps = 12/171 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MISLI A + IG EN + L D+ F + T KP+IMG T+ S+G +PL R N Sbjct: 1 MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGHKPLKDRFN 60 Query: 60 IILSSQPGT--------DDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQK 109 I+L+ P +S++ + + EI+VIGG + YE FLP A + Sbjct: 61 IVLTRSPMALTLDHLHLVGENLVFESLEYIQFMIEQSKDKEIVVIGGQQTYELFLPMASR 120 Query: 110 LYLTHIDAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +YLT I E D++FP + +W S H N H + ER+ Sbjct: 121 VYLTRIHHSFPEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK 171 >UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella multocida RepID=Q6A328_PASMU Length = 169 Score = 180 bits (459), Expect = 1e-44, Method: Composition-based stats. Identities = 49/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKN 59 SLI A+ R +G +N + W+LP D+ +FK T V+MGR +WESI RPLP R N Sbjct: 6 SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPQKYRPLPNRLN 65 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLP--KAQKLYLTHI 115 +L+ + T + + E +IGG ++Y+ L ++Y+T + Sbjct: 66 FVLTRDKNYSAEGATVIYDLKEVAQHLEGKNLTCFIIGGAQIYQLALETGLLNEMYVTQV 125 Query: 116 DAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT FP +WE D D ++ +S+ + R Sbjct: 126 HNTFEEADTFFPFVNWGEWEEEDILEQDKDEKHLYSFNIKKFTR 169 >UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2UP70_AKKM8 Length = 159 Score = 180 bits (458), Expect = 1e-44, Method: Composition-based stats. Identities = 59/154 (38%), Positives = 83/154 (53%), Gaps = 8/154 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A+A DR IG A+PW+LP DL FKR T PV+MGR T+ESIGRPLPGR+NI+L+ Sbjct: 10 VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTR 69 Query: 65 QPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123 P T + V V S E PEIMVIGG ++ +P +++++ + E DT Sbjct: 70 DPAWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADT 129 Query: 124 HFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 P +E +V E + + + E Sbjct: 130 FLPPFENRLERAVLKEHFE-------DFDLYLYE 156 >UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK Length = 166 Score = 180 bits (458), Expect = 1e-44, Method: Composition-based stats. Identities = 56/162 (34%), Positives = 86/162 (53%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I ++ A IG + W+LP DL FK T+N ++MGR TW++IGRPLPGR +++ Sbjct: 4 IRMVWAEDSTHAIGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLV 63 Query: 62 LSSQPGTD---DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 L+ Q D V SVDE + + +I + GG +Y F+P A L +T ID Sbjct: 64 LTHQKDFKTPYDDVIIAHSVDEVLDYIEKETRDISIAGGAAIYHAFMPYATDLIVTRIDV 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + GDT + ++ V + HD D ++ +S+ E ER+ Sbjct: 124 TIAGDTFVDAIDLSQFKLVSATAHDKDDKHDYSFVVERYERQ 165 >UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM 15894 RepID=D1BYH5_XYLCX Length = 185 Score = 180 bits (458), Expect = 1e-44, Method: Composition-based stats. Identities = 60/185 (32%), Positives = 81/185 (43%), Gaps = 26/185 (14%) Query: 1 MISLIAALAVDR----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLP 55 MI+LI A A D VIG +PW + D F+ T PV+MGR TW+S+ RPLP Sbjct: 1 MIALIWAQARDTAGRPVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPRRPLP 60 Query: 56 GRKNIILSSQPGTDDR---------------VTWVKSVDEAIAACGDVPE---IMVIGGG 97 GR N++++ QP V ++DEA+ P + +IGG Sbjct: 61 GRTNVVVTRQPDWRPDDDGAVVTAGAPEATAVVVATTLDEALDGATQAPGGDLVWIIGGA 120 Query: 98 RVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD---ADAQNSHSYCFE 154 +Y Q L A +L +T ID V+GD P +P W D S Y F Sbjct: 121 EIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHWHEGQHGHGDWVSPARPESPRYRFR 180 Query: 155 ILERR 159 RR Sbjct: 181 TYVRR 185 >UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST Length = 163 Score = 180 bits (457), Expect = 2e-44, Method: Composition-based stats. Identities = 56/139 (40%), Positives = 83/139 (59%), Gaps = 6/139 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+LI A A + IG +N +PW+ P DL F+R TL +IMGR+TW+S+ +PL R N Sbjct: 1 MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPFKPLKNRFN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I++SS P D T V S+DEAI + IGG +Y+ L +A +L +T +D Sbjct: 61 IVVSSNPDAAD--TVVASLDEAIDLARSEGYARLYGIGGAGIYKGMLARADRLMITEVDL 118 Query: 118 EV-EGDTHFPDYEPDDWES 135 E+ + D FP++ P++W Sbjct: 119 EIDDADAFFPEFPPEEWRV 137 >UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2 Length = 157 Score = 179 bits (455), Expect = 3e-44, Method: Composition-based stats. Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 7/161 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI LI A + + VIG +PW + + +FK T+ V+MGR ++E IG PLP R+NI Sbjct: 1 MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + + + V S+ EA+A D I + GG VY++ +P +Y+T +D + Sbjct: 61 IVSKTMKYEGENLITVSSLAEALAL-SDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNI 119 Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E GD FP+++ +D++ + E + + Y R+ Sbjct: 120 EDGDVFFPEFDVNDFDLIIGETFGENTK----YTRTTYIRK 156 >UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organisms RepID=Q2S5H3_SALRD Length = 186 Score = 179 bits (454), Expect = 4e-44, Method: Composition-based stats. Identities = 67/168 (39%), Positives = 96/168 (57%), Gaps = 17/168 (10%) Query: 2 ISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPG 56 + +IAA+A +RVIG + +PW++P DL FK+ T P++MGR T+ESI G PLP Sbjct: 21 LVIIAAVAEDNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIVHQFGGPLPD 80 Query: 57 RKNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 RK ++L++Q + V SVD A+AA D + + GG VYEQFLP A +L LT Sbjct: 81 RKMVVLTTQDDYEAYPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLELTL 140 Query: 115 IDAEVEGDTHFPDYEP---DDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ EGDT FP +E D +E DA++ + F ER+ Sbjct: 141 VEGAYEGDTFFPPFEHLIGDVFEET-----AVDARDG--FRFVTYERK 181 >UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacteria RepID=DYR13_ECOLX Length = 165 Score = 179 bits (454), Expect = 4e-44, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 81/160 (50%), Gaps = 6/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+AA+ +RVIG +PW +P + F+R T +K V+MGR T+ESIG+PLP R ++ Sbjct: 8 IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVV 67 Query: 62 LSSQPGT-DDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS Q G V ++ + E+ V G VY LP A ++L+ + Sbjct: 68 LSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTF 127 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP ++E V SE Q + +Y + RR Sbjct: 128 EGDAFFPVLNAAEFEVVSSET----IQGTITYTHSVYARR 163 >UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI0001874368 Length = 176 Score = 178 bits (452), Expect = 6e-44, Method: Composition-based stats. Identities = 58/160 (36%), Positives = 77/160 (48%), Gaps = 4/160 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + +I A + +IG MPW+LP DL FK T+ PVIMGR TW+S+ RPLPGR+ Sbjct: 15 VGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNPKFRPLPGRR 74 Query: 59 NIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 NI+LS S++ A+AA D P +IGGGRVY L A + +T ID + Sbjct: 75 NIVLSRSVSDFPGAESATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVTDIDTD 134 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V + DW V Y F +R Sbjct: 135 VSVPVPVMAPDLYDWVRVEDGPWQTSTT-GLRYRFCTWQR 173 >UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus faecium RepID=DYR_ENTFC Length = 167 Score = 177 bits (450), Expect = 9e-44, Method: Composition-based stats. Identities = 51/162 (31%), Positives = 92/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59 M + A + +IG + +PW LP D+ +F+ +T++K ++MGR T+E +G+ LP R Sbjct: 1 MFISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHI 60 Query: 60 IILSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L++Q + + S+DE +A D+PE I V GG R+++ LP+ + ++ T ID Sbjct: 61 IVLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 AE EGDT + + +E V + +N + + F+ ++ Sbjct: 121 AEFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQKWQK 162 >UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400 RepID=Q13PE2_BURXL Length = 171 Score = 177 bits (450), Expect = 1e-43, Method: Composition-based stats. Identities = 61/157 (38%), Positives = 84/157 (53%), Gaps = 7/157 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A +RVIG+ N +PW +P + F+ T+N+ V+MGR T+ESIG+PLPGR ++ Sbjct: 7 VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLV 66 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LSS V VKS E AA + P I V GG +VY +P A +YLT ID Sbjct: 67 LSSGTSRLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDLRP 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 GD FP+ P+ + S Y F Sbjct: 127 PGDAFFPEI-PERFSLPDSVDFPG----EIRYTFNTY 158 >UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes RepID=C3XD45_OXAFO Length = 163 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 56/160 (35%), Positives = 89/160 (55%), Gaps = 7/160 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS + A+A +RVIG + MPW++P + F+ T+ K +I+GR T ESIGR LP R II Sbjct: 4 ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITII 63 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S + + V +DEAI + +I++ GGG ++ Q LP K+YL+ + A+ Sbjct: 64 VSRKKDYEVPGAHVVHDIDEAIRLAREFGKEDIVIGGGGELFSQTLPVTDKVYLSIVHAD 123 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +G+T +P+ +++ + DA S Y F ER Sbjct: 124 FDGETFYPELPKEEFVEKARKEIDA----SIPYAFVEFER 159 >UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deuterostomia RepID=C3Z0P2_BRAFL Length = 185 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 53/179 (29%), Positives = 87/179 (48%), Gaps = 23/179 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 +SL+ A + IG++ +PW L D+ +F R T V+MGR TW SI Sbjct: 6 LSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTSGTEEAGKQNAVVMGRKTWFSIPDRF 65 Query: 52 RPLPGRKNIILSSQPGTDDRV--TWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103 RPLP R N++LS T S++EA+ + + ++ +IGG VY+ Sbjct: 66 RPLPKRLNVVLSRNLTTPPEGAHHLAGSLEEAVKMLTETTVADTIDKVFIIGGNSVYKDA 125 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158 L P ++YLT + +V DT FP+ + D ++ V + + +N Y +E+ E+ Sbjct: 126 LSHPCCHRVYLTRVYKDVHCDTFFPNMD-DTFKLVSDPTIPSEMQEENGIEYKYEVYEK 183 >UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase protein n=1 Tax=Spiroplasma citri RepID=Q14P23_SPICI Length = 160 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 12/164 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI L+ A+ + +IG + +PW+L +L FK TL + ++ GR T+E IG PLP RK + Sbjct: 1 MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTL 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +L+ V V + I +I + GG ++YE LP A +L ++ I Sbjct: 61 VLTRHLDYQIKHPDVEVVTDLTAIINFYHQNPTEDIYICGGKKIYEATLPYADELIISLI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + +GDT+FP ++ + + + + + + +R+ Sbjct: 121 KGKYQGDTYFPSFDLNQFTLIKLNEYQQ-------FVIKYYKRK 157 >UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (class) RepID=C5CC92_MICLC Length = 186 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 19/176 (10%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 +I++I A RVIG + MPW++P DLA F+ +T PVIMGR TWES RPLPGR Sbjct: 11 VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFPARFRPLPGR 70 Query: 58 KNIILSSQPGTDD---------RVTWVKSV---DEAIAACGDVPEIMVIGGGRVYEQFLP 105 NI++S + V A A + VIGG +Y+Q L Sbjct: 71 TNIVVSRTLTATEQAGAQLRAAGAVVVPDFGAALAAAAEADGCDTVWVIGGATLYDQALD 130 Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD---ADAQNSHSYCFEILER 158 A + +T IDA+V+GDTH P + W + D+ + + FE ER Sbjct: 131 VASRAEVTVIDADVDGDTHAPPLDAR-WRRTAVDPAPDAWLDSASGPRHRFERWER 185 >UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0 Length = 227 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 64/181 (35%), Positives = 89/181 (49%), Gaps = 24/181 (13%) Query: 2 ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53 ++LI A A D IG E MPW+LP DL FK T++ PVIMGR TWE++ RP Sbjct: 37 VNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRP 96 Query: 54 LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103 LP R NI+LS T V +++EA+ D EI VIGG +++ Q Sbjct: 97 LPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQM 156 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD----YEPDDWESVFSEFH--DADAQNSHSYCFEILE 157 LP A K+Y+T +DA+V D + PD W+ + + + Y + E Sbjct: 157 LPMASKIYMTQVDAKVNADAYAPDLTEALNNGSWKLMENSGWLTPKKPEGIDRYRYLTFE 216 Query: 158 R 158 R Sbjct: 217 R 217 >UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35E5E Length = 167 Score = 176 bits (447), Expect = 2e-43, Method: Composition-based stats. Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 8/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + I A+ IG + + +LP D+ +F+ T K V+MGR T +S +PL R N Sbjct: 1 MKAIVAVDEAWGIGKDGKLLTHLPEDMKFFRTVTKGKVVVMGRKTLQSFPDAKPLKNRIN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+S + + + +SV +A+ D ++ +IGG VYEQFLP Y+T + Sbjct: 61 IVLTSDAALNGEGLIVCRSVADALRQLKEYDSDDVYIIGGQSVYEQFLPYCDTAYVTRMK 120 Query: 117 AEVEGDTHFPDYEPDD-WESVFSEFHDADAQNSHSYCFEILERR 159 + DT F + + + WE E D + F + R Sbjct: 121 RDFGADTWFVNLDRQEGWEET--ETGDEKEYEGLHFTFCTYKNR 162 >UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE Length = 187 Score = 176 bits (447), Expect = 3e-43, Method: Composition-based stats. Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 21/178 (11%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51 S I A+ + R IG N +PW + D+ +F T VIMGR WESI Sbjct: 8 FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67 Query: 52 RPLPGRKNIILSSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104 RPL GR NI+LS +S ++A+ + + V GG +Y+ + Sbjct: 68 RPLKGRLNIVLSRTLSEPPQGAQLCRSFEQALTILSTDPYTKKIENVFVCGGSALYKDAM 127 Query: 105 PK--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILER 158 ++Y+T+ID E + D FP+++ + + V + + Y F + +R Sbjct: 128 AHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLVEDPDVPSVQHEEKGIKYKFCVYDR 185 >UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHY5_9BACT Length = 141 Score = 175 bits (446), Expect = 3e-43, Method: Composition-based stats. Identities = 56/141 (39%), Positives = 81/141 (57%), Gaps = 4/141 (2%) Query: 20 MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD-RVTWVKSV 78 MPW + DL FK T+ PVIMG++TW SIG+PLPGR+NI+LS S+ Sbjct: 1 MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAHSL 60 Query: 79 DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFS 138 +EA+ E +IGG V++QFLP A K+ +T I +E EGDT+FP + +DW + Sbjct: 61 EEALKMVEG-QEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDW--ILQ 117 Query: 139 EFHDADAQNSHSYCFEILERR 159 E + + + C +I R+ Sbjct: 118 ESSSLLSSSGYELCLQIYIRK 138 >UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus faecium RepID=C2HC06_ENTFC Length = 172 Score = 175 bits (446), Expect = 3e-43, Method: Composition-based stats. Identities = 50/162 (30%), Positives = 91/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59 M + A + +IG +PW LP D+ +F+ +T+++ ++MGR T+E +G LP R Sbjct: 1 MFISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLSLPYRHI 60 Query: 60 IILSSQPG--TDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L++QP T + + S+DE +A + +I V GG R++++ LP +++ T ID Sbjct: 61 IVLTTQPNFRTKENAEVMHSIDELLAYSQTISEDIYVSGGSRIFQELLPYTGRIWRTLID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGDT+ D + D+ + D +N +++ F+ ER Sbjct: 121 STFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER 162 >UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RRK6_9EURY Length = 181 Score = 175 bits (446), Expect = 3e-43, Method: Composition-based stats. Identities = 59/168 (35%), Positives = 83/168 (49%), Gaps = 20/168 (11%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60 I A+A + VIG + MPW++PADL FK T++ P+IMGR T+E I G PLPGR + Sbjct: 19 IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGILEALGEPLPGRTTV 78 Query: 61 IL-SSQPGTDDRVTWVKS--------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLY 111 +L S T + +S A I V GG VYEQFL +L Sbjct: 79 VLTSRDLETPENAVTARSLEEALEAAETAARERHDAADRIFVAGGATVYEQFLSALDRLI 138 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +T + E +GDT+FPD++ ++ V + D + F RR Sbjct: 139 VTEVHEEPDGDTYFPDWDRASFDDVSRDDRDG-------FAFVEYVRR 179 >UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis virescens RepID=DYR_HELVI Length = 185 Score = 175 bits (445), Expect = 4e-43, Method: Composition-based stats. Identities = 54/179 (30%), Positives = 82/179 (45%), Gaps = 22/179 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 ++LIAA + IG+ A+PW L ++A+F T VIMGR TW+ I Sbjct: 6 LNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTSKVSEPTKVNAVIMGRRTWDCIPDKY 65 Query: 52 RPLPGRKNIILSSQPGT-----DDRVTWVKSVDEAIAACGDVPEI---MVIGGGRVYEQF 103 RPL R NI+L+ + + V +DEAI +I VIGG +Y Sbjct: 66 RPLQDRVNIVLTHNVDSVKENVPEGVMVFPGLDEAIKYIEGREDIESTWVIGGSSIYRAA 125 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158 + P K+YLT I + DT FP+ + + V E + + + SY F + ++ Sbjct: 126 MTHPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQVEGNISYYFRVYKK 184 >UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37 RepID=A3K5B9_9RHOB Length = 153 Score = 175 bits (444), Expect = 5e-43, Method: Composition-based stats. Identities = 61/142 (42%), Positives = 82/142 (57%), Gaps = 7/142 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+LIAA +R IG + +PW++P DLA FKR TL ++MGR TWES+ +PL R N Sbjct: 1 MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPFKPLKDRLN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I++S + V V SV++AIA I IGG R+YE LP A +L +T +D Sbjct: 61 IVVSRDTSLHEHV--VGSVEDAIALAQSQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDT 118 Query: 118 EV-EGDTHFPDYEPDDWESVFS 138 V E D FPD + W V + Sbjct: 119 VVEEADAFFPDVG-EGWREVST 139 >UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRL8_9FIRM Length = 161 Score = 174 bits (443), Expect = 7e-43, Method: Composition-based stats. Identities = 49/161 (30%), Positives = 78/161 (48%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + +I A+ + IG + + +L DL K T+ ++MG T+ S RPLP R+N+ Sbjct: 1 MEIIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPKRPLPDRENL 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ P + VDE + + I V+GGG VYEQ LP +K ++T I Sbjct: 61 IITHHPENYPGIKCFTGVDEFLEYSKTADKPIFVLGGGSVYEQLLPYCEKAHITKILHSF 120 Query: 120 EGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159 E DT FP+ + + DWE E + + + + RR Sbjct: 121 EADTFFPNLDNNPDWEKENEEDIVTGEK--YPFRYVTYVRR 159 >UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE Length = 165 Score = 174 bits (443), Expect = 7e-43, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 10/165 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 ++ LI A + VIG + MPW +P DL FK+ T+ PV+MGR TW+S+ RPLPGR Sbjct: 3 VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62 Query: 58 KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS Q + S++E I+ PE+ VIGG ++Y LP A + +T +D Sbjct: 63 RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122 Query: 117 AEV---EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + + D P + D W V E+ + + Y R Sbjct: 123 TYLLHEDDDVLAPVLD-DTWVGVTGEWLVSCS--GLRYRLHSYHR 164 >UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium RepID=D2Q8R3_9BIFI Length = 224 Score = 174 bits (442), Expect = 1e-42, Method: Composition-based stats. Identities = 62/182 (34%), Positives = 84/182 (46%), Gaps = 25/182 (13%) Query: 2 ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53 ++LI A A D IG E MPW LP D+ F T++ PVIMGR TWE++ RP Sbjct: 39 VNLIWAQARDKEGRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSPKFRP 98 Query: 54 LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103 LP R NI++S P T V ++D+A+ D EI +IGG +V+ Sbjct: 99 LPNRDNIVISHDPAYSAPGATVVDTLDDALDLARQEAIPDDGLDRSEIWIIGGAQVFRDA 158 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDY----EPDDWESVFSEFHDADAQNSHS---YCFEIL 156 LP A K Y+T I V+ DT+ PD E W + S + F Sbjct: 159 LPFADKAYVTQISMHVDADTYAPDIASLAESGAWRMAEEGVWQGTQKGSDDIAGFRFVTY 218 Query: 157 ER 158 E+ Sbjct: 219 EK 220 >UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF Length = 193 Score = 174 bits (441), Expect = 1e-42, Method: Composition-based stats. Identities = 56/179 (31%), Positives = 89/179 (49%), Gaps = 28/179 (15%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKP-----------VIMGRHTWESIG-R 52 I A++ +R IG N +PW++P DL FK T + VIMGR T+ES+G + Sbjct: 11 IVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTAETDAYVDTGLKGIVIMGRKTFESMGSK 70 Query: 53 PLPGRKNIILSSQPGTDD--------RVTWVKSVDEAIAACGDV------PEIMVIGGGR 98 PLP R N I+++Q V V ++D+A+ +V I VIGG R Sbjct: 71 PLPKRVNFIVTTQMDYAQQKGLEGLKDVHVVHNLDDALTHAANVAHGLKFETIWVIGGER 130 Query: 99 VYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 V+++ + ++ LT +D ++E GD +P+ P+D+E D ++ SY F Sbjct: 131 VFKRAMMFTDRIELTVVDTDIEDGDAFYPEI-PEDFELTQESESFTDEKSGLSYKFMTY 188 >UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WYQ0_HALHL Length = 164 Score = 174 bits (441), Expect = 1e-42, Method: Composition-based stats. Identities = 60/161 (37%), Positives = 80/161 (49%), Gaps = 8/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+A + + VIG + PW+ DL FK T PVIMGR T +IGRPLP R NI+ Sbjct: 4 IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIV 63 Query: 62 LSSQPGTD-DRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 L+ PG D V + A +M++GGG VY FLP+A +L LT +D Sbjct: 64 LTRDPGFHADGVEVATDPEAALARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDD 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP P +W+ E ++ + F L R Sbjct: 124 APPGDTTFPAIGP-EWQETAREE---AEEDGYRLTFRTLLR 160 >UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW Length = 166 Score = 173 bits (440), Expect = 2e-42, Method: Composition-based stats. Identities = 56/167 (33%), Positives = 90/167 (53%), Gaps = 12/167 (7%) Query: 1 MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58 ++SLIAA+ IG+ MPW ++ D+ +F+ T VIMGR T+ES+G +PLP RK Sbjct: 2 IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTGYAVIMGRVTFESLGSKPLPNRK 61 Query: 59 NIILSSQPGTD-----DRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLY 111 NI++SS T+ D + + KS +++I+ +I +IGG +Y++ L A +Y Sbjct: 62 NIVISSNVNTELLNKYDNLFYEKSFEDSISKLLLEKNKQIFIIGGESIYKKALDYADMIY 121 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LTHID + D FP+ + + ++S + N S R Sbjct: 122 LTHIDKDYHCDRFFPEIDTNLFQSDELKTFFY---NDISVNIIKYTR 165 >UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A0W8_PELCD Length = 167 Score = 172 bits (437), Expect = 3e-42, Method: Composition-based stats. Identities = 54/159 (33%), Positives = 82/159 (51%), Gaps = 8/159 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++++ A+ +R+IG +PW++P DLA F+R T ++MGR T+ESIGRPLPGR NI+ Sbjct: 16 MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIV 75 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S + + + EA+ +I IGG +Y Q L A KL ++ I Sbjct: 76 VSRSMPPVEGLRVCRHFAEALQVADQGNGDIFFIGGCEIYRQALIVAGKLSVSWIRKNYP 135 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP+Y DDW + + + I RR Sbjct: 136 GDCRFPEYRSDDWLIEQEQDYSE-------FRHIIYRRR 167 >UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H0N2_9FIRM Length = 162 Score = 172 bits (436), Expect = 4e-42, Method: Composition-based stats. Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 6/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 ++ I + + IG + + +L DL +FK T+ K +I+GR T ES +PLPGRK Sbjct: 1 MNAIVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPGGKPLPGRKT 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ + S E + D+ ++ V GGG +Y+QFL K ++T I Sbjct: 61 IVLTRNTSYKAEGAYVCHSKQEVLEKVKDLHPADVFVAGGGAIYKQFLNDVDKGFVTKIC 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E GDT FP+ + D+ + + +N + F I R Sbjct: 121 NEYSGDTFFPNLDEDE-DFALESEGETIEENGVKFKFCIYNR 161 >UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3 Length = 163 Score = 171 bits (435), Expect = 5e-42, Method: Composition-based stats. Identities = 49/165 (29%), Positives = 83/165 (50%), Gaps = 12/165 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 ++LIAA+ + IG N + +P D +F+ T K V+MGR T ES RPL R N Sbjct: 1 MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPNSRPLKNRTN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ P + + V S+DE + +I +IGG ++YEQ + + ++T +D Sbjct: 61 IVLTHNPSYEVEGAVVVHSLDELHKELEKYNSEDIYIIGGQKIYEQLVDECDVAHITKVD 120 Query: 117 AEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHS--YCFEILER 158 E + D +FP+ + +W+ D++ Q + F E+ Sbjct: 121 FEYDADAYFPNLDEKPEWQIT----GDSEEQTYFDLEFYFLRYEK 161 >UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI Length = 178 Score = 171 bits (434), Expect = 7e-42, Method: Composition-based stats. Identities = 52/168 (30%), Positives = 86/168 (51%), Gaps = 14/168 (8%) Query: 2 ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKP-----VIMGRHTWESIG---R 52 I++IAA R IG +N +PW LP D+ +F+ T + VIMGR TWES+ R Sbjct: 9 INVIAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEIRVGVIMGRRTWESVPPKFR 68 Query: 53 PLPGRKNIILSSQPGTDD-RVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLP-KAQK 109 P R N++L+S+ + +++++A+ C +V I VIGG VY + L + Sbjct: 69 PFKNRFNVVLTSREDFEAKGAVIARTLEDAVKKCSNNVDSIWVIGGSGVYAEALNKYPCR 128 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 +YLT ID E + D FP + ++ +N ++ F++ + Sbjct: 129 VYLTEIDKEFDCDAFFPPLDEKKYKLAS--VSPDHQENDITFRFKVYD 174 >UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae RepID=C7N8V9_LEPBD Length = 173 Score = 171 bits (434), Expect = 7e-42, Method: Composition-based stats. Identities = 54/177 (30%), Positives = 94/177 (53%), Gaps = 26/177 (14%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M SLI A+ + IG N + W++P DL FK+ T+ K VIMG++T++SIG+PLP RKNI Sbjct: 1 MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNI 60 Query: 61 ILSSQP---------------GTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQF- 103 +LS P + ++ ++ + I + EI +IGGG +Y++ Sbjct: 61 VLSRNPLEIEEKIKEDRKKYENENTKLELCDNLQKIIDKYKNSEEEIFIIGGGEIYKKAF 120 Query: 104 -LPKAQKLYLTHID-AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +++Y++H++ ++ DT+FP + W + E +D + F I E+ Sbjct: 121 EMKIVKRIYMSHVNFSDKNADTYFPKIDLKKWVVITKENYDG-------WRFCIYEK 170 >UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA Length = 168 Score = 171 bits (434), Expect = 7e-42, Method: Composition-based stats. Identities = 51/164 (31%), Positives = 89/164 (54%), Gaps = 6/164 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 MI I A +IG + MPW+LPA+ FK T+N+ ++MGR T+E + R LPGR + Sbjct: 1 MIIGIWAEDEAGLIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMNKRVLPGRIS 60 Query: 60 IILSSQPGT---DDRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 IIL+ +++V + S E + ++ + GG + F + + LY T + Sbjct: 61 IILTRDETYQSDNEKVLIMHSPKEVLDWYHKQNKDLFITGGAEILALFESELELLYRTVV 120 Query: 116 DAEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GDT+FP ++ ++ V +FHD D +NS+++ + E+ Sbjct: 121 HEKFKGDTYFPSTFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK 164 >UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C2_9FIRM Length = 159 Score = 171 bits (434), Expect = 8e-42, Method: Composition-based stats. Identities = 49/157 (31%), Positives = 83/157 (52%), Gaps = 5/157 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LIAA+ +R +G N M W+LP DL +F++ T ++MGR T+ES+ LP R +++ Sbjct: 3 LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVV 62 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +S + + +SV+E + DV EI IGGG +Y + L A +L LT IDA+ Sbjct: 63 ISRTCKDLGEDIEMCESVEEFMKRYKDVDEEIYCIGGGMIYSEMLKYASRLVLTQIDADA 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 + + +FP+++ + +N Y Sbjct: 123 DAEVYFPEFDESLYNKKILSNI---EENGVFYQHVEY 156 >UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D395_9BACT Length = 201 Score = 170 bits (433), Expect = 9e-42, Method: Composition-based stats. Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 45/189 (23%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQP- 66 ++++RVIG +N +PW+LP D WFK+ T V+MGR T+ES+GRPLP R NI+++ +P Sbjct: 1 MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPL 60 Query: 67 ----------------------------------GTDDRVTWVKS---VDEAIAACGDVP 89 ++ V V+ + +A Sbjct: 61 RLARDPQFKATVGQARVGHWQARFGRPYQLGFERLSERDVWLVRDPRKLADAFEKARPSR 120 Query: 90 EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSH 149 ++ VIGG ++YEQ LP+ LYL+ + EVEGD FP+ E DDW + D Sbjct: 121 QLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPELE-DDWYLHDTPLRTPD----- 174 Query: 150 SYCFEILER 158 + + R Sbjct: 175 -FEVQHYRR 182 >UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BYZ5_BEUC1 Length = 169 Score = 169 bits (428), Expect = 4e-41, Method: Composition-based stats. Identities = 51/143 (35%), Positives = 78/143 (54%), Gaps = 10/143 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MI +I A A D VIG +PW++P D A FK T V+MGR TW+S+ RP+P R Sbjct: 1 MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60 Query: 58 KNIILSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +N++++ Q + D S+ +A+ C PE ++GG ++Y + +P A L +T +D Sbjct: 61 RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120 Query: 117 --AEVEGD---THFPDYEPDDWE 134 +VEG H P P +W Sbjct: 121 LALDVEGAPDVVHAPPIGP-EWR 142 >UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase n=2 Tax=Veillonellaceae RepID=C9KQJ5_9FIRM Length = 342 Score = 168 bits (427), Expect = 4e-41, Method: Composition-based stats. Identities = 50/164 (30%), Positives = 73/164 (44%), Gaps = 17/164 (10%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 +S+IA + R IG + +LP D+ F+ T VIMGR T ES+ RPL R+N Sbjct: 168 LSMIACIDEGRGIGYRGELLVHLPEDMKHFRALTEGHVVIMGRRTMESLPGKRPLVNRQN 227 Query: 60 IILSSQPGTDDRVTWVKSVDEA------IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 I+LS Q + S+ + + A ++ IGG +Y LP A ++ LT Sbjct: 228 IVLSRQLEGAEGFLICHSLPDLWRALGRLRAEKPQRKLWCIGGEELYRALLPYAHEVCLT 287 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 + A D FP + D+ V D D + FE E Sbjct: 288 RLKAVYPADCFFPPLD--DFSLV-----DTDDREGL--VFERYE 322 >UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacterium acnes RepID=D1YEK5_PROAC Length = 156 Score = 168 bits (427), Expect = 5e-41, Method: Composition-based stats. Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 11/161 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + IAA+A + VIG M W++ D FK T+ +I GR T+E IG+ LPGR++II Sbjct: 3 VVAIAAVADNGVIGSGQDMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGK-LPGRRHII 61 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 + P + + V S +A+ + E V GGG++Y +L +T + Sbjct: 62 CTRDPHWSHEGVDVATSPRQAVEMAREAGEEICFVAGGGQIYADTFELCDELDITEVHQN 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 G FP +P+ W V E D + F RR Sbjct: 122 PNGAARFPAIDPEVWVEVRRESRDG-------FDFVGYRRR 155 >UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EC32 Length = 190 Score = 168 bits (426), Expect = 6e-41, Method: Composition-based stats. Identities = 54/177 (30%), Positives = 80/177 (45%), Gaps = 20/177 (11%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 +LIAA+ + IG + +PWNL +L +F R T + VIMGR TW+S+ Sbjct: 5 FNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHNW 64 Query: 52 RPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLP 105 +PLPGR N +L++Q D +++ I + VIGG +VYE L Sbjct: 65 KPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVYESVLK 124 Query: 106 K--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158 + YLT I E E D F D++ V + +N Y F + E+ Sbjct: 125 YGLCHRFYLTRIKKEFECDCFFNYDFTKDFKEVSDDRVPKGVQKENEIEYVFHVYEK 181 >UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus RepID=B9DU71_STRU0 Length = 165 Score = 167 bits (425), Expect = 7e-41, Method: Composition-based stats. Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60 I I A + VIG +PW LP +L FK TLN ++MGR T+E + R LP R+ + Sbjct: 5 IIAIWAEDENGVIGANGTLPWYLPKELQHFKNTTLNHAILMGRVTFEGMKRRLLPNRQTL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +L+S D + S+++ + + VIGG +V + F K+ T + + Sbjct: 65 VLTSDESYHVDGALTMTSLEKTLEWYHAQENNLYVIGGQKVLQTFDGHFNKIIKTVVHHQ 124 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT+ P+ + + F++ D QN + + IL R+ Sbjct: 125 FDGDTYRPELDLSPFVEEDCFFYERDDQNPYDFTVHILVRK 165 >UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis 101-4-CHN RepID=C7XU42_9LACO Length = 166 Score = 167 bits (425), Expect = 9e-41, Method: Composition-based stats. Identities = 46/159 (28%), Positives = 72/159 (45%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS + A IG +PW+LP DL FK T + P++MG T+ SIGRPLP R NI+ Sbjct: 3 ISFVWAEDEAGWIGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIV 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAA----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +S P D+V V ++++ + D E+ +IGG ++ Q + L+ T + Sbjct: 63 VSHHPVAVDQVITVTNIEDLMNLIFKRYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMG 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 GD + W+ + + FE Sbjct: 123 NHHGDVKMIPIDYHQWQLTKKTPVYNSKTGALNCYFEEW 161 >UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WVU0_ACYPI Length = 184 Score = 167 bits (424), Expect = 1e-40, Method: Composition-based stats. Identities = 50/174 (28%), Positives = 85/174 (48%), Gaps = 18/174 (10%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG---R 52 S+IAA++ + IG + +PW + ++ +F T VIMGR TW+SI R Sbjct: 10 SVIAAVSKNGGIGYKGNLPWKIKKEMEYFNLMTTRVNLKGVQNAVIMGRCTWQSIPDKYR 69 Query: 53 PLPGRKNIILSSQPGT-DDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLP--K 106 PL GR N+++S + + V ++EA+ + + + VIGG +Y++ + Sbjct: 70 PLKGRINVVISKTLNSVPEGVLLYPKLEEALKSLYLNDRIENLWVIGGSGLYKEAVNDKN 129 Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158 +KL++T ID E DT FPD++ +E N Y F++ +R Sbjct: 130 CKKLFITKIDQEYLCDTFFPDFDTKKFEETSEANVPKGIQEDNGIKYEFKVFKR 183 >UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R3F1_JONDD Length = 191 Score = 167 bits (424), Expect = 1e-40, Method: Composition-based stats. Identities = 56/164 (34%), Positives = 79/164 (48%), Gaps = 10/164 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +SLI A +++ VIG +PW+ P DLA F++ T VIMGRHTWES+ PLP R NI Sbjct: 11 LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPVTPLPQRVNI 70 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACG-----DVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +L+S V + +A+ I VIGG +VY+ F+ A +L +T Sbjct: 71 VLTSDRDYRAPGARVVTTPQQALDLAHWYTQVGHQAIWVIGGRQVYDTFMDYATQLIVTT 130 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +EGDT P P V E H + + R Sbjct: 131 VGTVIEGDTEAPRIPP---HFVPQEPHQLATHSDYEVTVTTWLR 171 >UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8NZB9_ERYRH Length = 150 Score = 167 bits (423), Expect = 1e-40, Method: Composition-based stats. Identities = 44/158 (27%), Positives = 83/158 (52%), Gaps = 9/158 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI +I A+ R IG+ +MPW+ DL F+++TLN+ V+MGR T+E + + L R+ Sbjct: 1 MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIY 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +++ ++ + +++ + +I + GGG +Y Q LP A +L +++I +V Sbjct: 61 VVTRNASIENAIPDLRAF--LMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDVI 118 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FPD+ +++ + ++ ER Sbjct: 119 GDTFFPDFSDLEFKIKNQVEYS-------TFKQVTYER 149 >UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadaceae RepID=Q0G0R9_9RHIZ Length = 178 Score = 167 bits (423), Expect = 1e-40, Method: Composition-based stats. Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + A A + VIG + MPW++P+DL ++ T+ KP+IMGR T E+IG+ L GR +I+ Sbjct: 8 FVAVVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIV 67 Query: 62 LSS-QPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 L+ D EAIA + EI V+GG +Y ++ LT Sbjct: 68 LTRENRLAVDGAMLASGPAEAIAKAIECASARRASEIAVVGGAEIYRLLWDHIDRIALTE 127 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +DAE EGD FP + ++E + E ++S + F+ +RR Sbjct: 128 VDAEPEGDAVFPAIDESEFELLSEEPWIRGERDSAATRFKSYQRR 172 >UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1 RepID=Q8JKV3_9VIRU Length = 264 Score = 167 bits (423), Expect = 2e-40, Method: Composition-based stats. Identities = 60/174 (34%), Positives = 88/174 (50%), Gaps = 18/174 (10%) Query: 2 ISLIAALAVDR-VIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG--- 51 I+LI A+ + IGM NA+PW+L ++A F + T VIMGR TWESI Sbjct: 87 INLIVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNKNAVIMGRLTWESIPKRF 146 Query: 52 RPLPGRKNIILSSQP-GTDDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFL--P 105 RPLPGR NI+L+++ G D T V + DEAI GD+ VIGG VY + P Sbjct: 147 RPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRGDIETAWVIGGASVYAAAMTHP 206 Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +++LT I E + FP + +E + + Y +++ ++R Sbjct: 207 NCHQIHLTAIKKYYECNVFFPKIDTTRFELISET--PCTREGDVQYSYKVYQQR 258 >UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota RepID=DYR_DROME Length = 182 Score = 166 bits (422), Expect = 2e-40, Method: Composition-based stats. Identities = 51/178 (28%), Positives = 85/178 (47%), Gaps = 22/178 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRN-------TLNKPVIMGRHTWESIG--- 51 +LI A+ + IG+ +PW + ++L +F R T V+MGR T+ + Sbjct: 4 FNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTTKRTSDPTKQNAVVMGRKTYFGVPESK 63 Query: 52 RPLPGRKNIILSSQPGTDD---RVTWVKSVDEA---IAACGDVPEIMVIGGGRVYEQFL- 104 RPLP R NI+LS+ D V +++ A + +V I ++GG VYE+ + Sbjct: 64 RPLPDRLNIVLSTTLQESDLPKGVLLCPNLETAMKILEEQNEVENIWIVGGSGVYEEAMA 123 Query: 105 -PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESV---FSEFHDADAQNSHSYCFEILER 158 P+ +LY+T I + + DT FP PD + V +N + ++ILE+ Sbjct: 124 SPRCHRLYITKIMQKFDCDTFFPAI-PDSFREVAPDSDMPLGVQEENGIKFEYKILEK 180 >UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RI81_TRIAD Length = 174 Score = 166 bits (422), Expect = 2e-40, Method: Composition-based stats. Identities = 55/174 (31%), Positives = 85/174 (48%), Gaps = 24/174 (13%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG---RPLPGR 57 + DR IG +N +PW L + +F R T + V+MGR+TW SI RPL R Sbjct: 1 MTRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNR 60 Query: 58 KNIILSSQPGTDD---RVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFL--PK 106 NI++SSQ ++ V V S+ E I V + ++GG VY+ F+ P+ Sbjct: 61 INIVISSQLRAEEVPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYKGFMSHPQ 120 Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158 ++YLT +DA E D FP+ DD++ + + +N Y F + +R Sbjct: 121 CDRIYLTKLDANYECDVFFPEMS-DDFKEISDPDVSQEVQEENGLKYTFHVYQR 173 >UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobacteriaceae RepID=C8WAC3_ATOPD Length = 162 Score = 165 bits (418), Expect = 6e-40, Method: Composition-based stats. Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 6/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 ++ I ++ D IG + + AD+ +F +T + VIMGR T ES PL GR+NI Sbjct: 1 MNAIVSVTRDWGIGCDGDLLIPNKADMKYFVEHTRSCTVIMGRKTLESFPGGPLKGRRNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++S + V V S +EA+ D ++ +IGG +Y L + Y+T D Sbjct: 61 VISRNTNYQVEGVEIVSSAEEALRLVKDEAPEKVWLIGGASIYRALLDRCSYAYVTKHDT 120 Query: 118 EVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILE 157 V+ DT+FP+ + D W+ E + ++ F + Sbjct: 121 VVDADTYFPNLDEDPAWKVCNEEDGGVTPE-GVAFKFVTYQ 160 >UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia floridanus RepID=Q7VQK5_BLOFL Length = 168 Score = 165 bits (418), Expect = 6e-40, Method: Composition-based stats. Identities = 63/166 (37%), Positives = 95/166 (57%), Gaps = 8/166 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 +ISLIAA ++ VIG +N +PW D+ WFK +T+ KPVIMGR T+ES+ +PLP R N Sbjct: 2 IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRLN 61 Query: 60 IILSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 I+LS + + +A++ E+M+IGGG VY F+ + ++YLT I Sbjct: 62 IVLSKHHILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRMYLTKI 121 Query: 116 DAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSY--CFEILER 158 D GD+ FP Y P++W V++ ++Y F+IL+R Sbjct: 122 DVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDR 167 >UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EGY7_9CLOT Length = 319 Score = 165 bits (418), Expect = 6e-40, Method: Composition-based stats. Identities = 55/168 (32%), Positives = 85/168 (50%), Gaps = 12/168 (7%) Query: 1 MISL--IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPG 56 MI + I A+ IG EN + +++P D+A+F++ TLNK V+MGRHT ES+ RPL Sbjct: 1 MIKMKCIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPKSRPLKN 60 Query: 57 RKNIILSSQPGTDD-RVTWVKSVDE---AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 R NI++S S+ + A++ C D ++ V+GG VY L + + Sbjct: 61 RLNIVMSRDRSLQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALI 119 Query: 113 THIDAEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159 T I + E D FP+ + D +W SE D + N Y F + + Sbjct: 120 TKIQGQREADRFFPNIDRDNNW--TLSEQSDVRSHNGLCYSFCVYANK 165 >UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1 Tax=Hydra magnipapillata RepID=UPI0001926A4C Length = 189 Score = 165 bits (418), Expect = 6e-40, Method: Composition-based stats. Identities = 56/177 (31%), Positives = 86/177 (48%), Gaps = 22/177 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG--- 51 + IAA+ + IG++ +PWNLP + +F+ T VIMG++TW SI Sbjct: 7 VHCIAAIDSEWGIGLKGKLPWNLPREYKFFQNITTKVISEGKQNAVIMGKNTWFSIPQQH 66 Query: 52 RPLPGRKNIILSSQ---PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQ 102 RPL R N+ILSS V S++ AI D V I VIGG RVY++ Sbjct: 67 RPLKNRLNVILSSSFIKEDYPKNVLLESSLEAAILRLSDEFYANTVENIFVIGGSRVYKE 126 Query: 103 FLP-KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEIL 156 + K+YLT I+ + D +P ++ + ++ + E D + +N SY F + Sbjct: 127 AMEKFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDKNKQIENGVSYTFHVY 183 >UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypothetical protein n=1 Tax=Nasonia vitripennis RepID=UPI00015B4DEB Length = 184 Score = 165 bits (418), Expect = 6e-40, Method: Composition-based stats. Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 22/179 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51 + LIAA + IG+ +PW L ++ +F + T V+MGR TWESI Sbjct: 5 LKLIAAACENMGIGVNGDLPWRLRKEMDFFTKMTSTTKDENKKNVVLMGRRTWESIPKKF 64 Query: 52 RPLPGRKNIILSSQP-GTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104 +PL R N++L+SQP + K++ EAI V ++ VIGG VY+ + Sbjct: 65 KPLSNRINMVLTSQPLDLGEDAIVCKNLPEAIEKISQSPLKDKVEQVWVIGGSLVYKTSM 124 Query: 105 --PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILERR 159 P +LYLT + + + D FP+ P+D+ V + + +E+ E++ Sbjct: 125 ESPNFYRLYLTRVKKDFKCDAFFPEI-PNDYILVKDPEVPEGIQEEKDIKFEYEVYEKK 182 >UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7 Length = 181 Score = 164 bits (416), Expect = 9e-40, Method: Composition-based stats. Identities = 53/180 (29%), Positives = 78/180 (43%), Gaps = 23/180 (12%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRPLPGR 57 M+ I A ++D VIG MPW++P DL FK T+ PVIMGR TWES+ RPLPGR Sbjct: 1 MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLTPKFRPLPGR 60 Query: 58 KNIILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT-- 113 NI+LS + T V ++D A+ + + +IGGG++Y L + + LT Sbjct: 61 DNIVLSRREPGEWSAGATVVDNLDAAL--HATLDDAWIIGGGQLYSSALDRVDTIELTLM 118 Query: 114 --HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQN------------SHSYCFEILERR 159 + D P+++ Y F +R+ Sbjct: 119 GVQVGDAYGADAVLAPSVPEEFSLSADSDWLTSESGHLTIPGQPPSELPMKYRFLTYDRK 178 >UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mansoni RepID=C4QMV9_SCHMA Length = 186 Score = 164 bits (415), Expect = 1e-39, Method: Composition-based stats. Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 21/177 (11%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG---R 52 ++++ A++ + IG +PW + D+ +FK T V+MGR TWESI + Sbjct: 3 LNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTKAHPGLKNAVVMGRVTWESIPESFK 62 Query: 53 PLPGRKNIILSSQPGTDDR-VTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLP 105 PL R NI++SS V V S++ AI + E+ +IGG R+Y++ L Sbjct: 63 PLKDRINIVVSSTLSHAPSFVQVVPSLNAAIDLLYNEEFSSIVDEVFIIGGYRLYKEALK 122 Query: 106 ---KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILE 157 ++Y THI +EV+ DT+FP + D + V AD +N ++ F + + Sbjct: 123 QSIYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTFKFCVYD 179 >UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocaceae RepID=B9YFM0_ANAAZ Length = 166 Score = 164 bits (415), Expect = 1e-39, Method: Composition-based stats. Identities = 54/167 (32%), Positives = 90/167 (53%), Gaps = 13/167 (7%) Query: 1 MISLIAALAVDRVIGMENA------MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPL 54 +ISLIAA++ +R++ +PW++P+DL F++ T PVI+GR ++ + PL Sbjct: 3 LISLIAAISENRILADSKKEHIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPL 62 Query: 55 PGRKNIILSSQPGT-DDRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLY 111 P R NIIL+ S+ EA+ A + EI + GGG ++ + + A KLY Sbjct: 63 PNRTNIILTRSHDYKAPGCLVFYSLSEAVTWAKMSEKEEIFIAGGGEIFAEAIKFANKLY 122 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LT ++ EGD +FP++ ++ +V E H +N + F +ER Sbjct: 123 LTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER 165 >UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae RepID=C0VZ67_9ACTO Length = 170 Score = 163 bits (414), Expect = 2e-39, Method: Composition-based stats. Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 11/169 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR--PLPGRK 58 ++ +I A + +G + M W++PAD FK++T+ P+IMGR +W+++GR PLP R+ Sbjct: 3 VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRFAPLPQRR 62 Query: 59 NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116 NI+++ + S++EAI+ E + + GG +YEQ +P A +L +T++D Sbjct: 63 NIVVTRNRDFIPEGGEVAFSIEEAISLASADSELVWIAGGAHIYEQAMPFADELVVTYLD 122 Query: 117 AEVEGD---THFPDYEPDDWESVFSEFHDADAQN---SHSYCFEILERR 159 V + P +P WE V +E DAD + + + RR Sbjct: 123 LNVSTAGPVVYAPQIDPAVWEVVKAE-SDADWREKSGDARWKVVVYRRR 170 >UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HP20_9RHOB Length = 154 Score = 163 bits (413), Expect = 2e-39, Method: Composition-based stats. Identities = 49/134 (36%), Positives = 78/134 (58%), Gaps = 6/134 (4%) Query: 7 ALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSSQ 65 A A + IG + +PWN+P DL +F+R TL +IMGR+TWES+ +PLP R N+++SS Sbjct: 2 ARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPVKPLPRRFNVVVSSN 61 Query: 66 PGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-EGD 122 T + SV AI I IGG +Y++ LP A +L ++ + +V + D Sbjct: 62 SDTAE--VVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVPDAD 119 Query: 123 THFPDYEPDDWESV 136 T FP+++ W+++ Sbjct: 120 TFFPNFDVAGWKAI 133 >UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorhabditis RepID=DYR_CAEEL Length = 189 Score = 162 bits (412), Expect = 3e-39, Method: Composition-based stats. Identities = 51/181 (28%), Positives = 76/181 (41%), Gaps = 25/181 (13%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 ++LI A+ + IG +PW + D+ +F T N V+MGR WESI Sbjct: 4 MNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNVSDQSKRNAVLMGRKCWESIPVTR 63 Query: 52 RPLPGRKNIILSSQ--PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103 RPL GR NI+LS Q D V S++ A+ + + I IGG +Y+ Sbjct: 64 RPLAGRLNIVLSRQLPAQKSDDYIVVNSLEAAMKLLSEPPFVDSIETIWNIGGAEIYDLA 123 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWE-----SVFSEFHDADAQNSHSYCFEIL 156 L +++LT I E D H + E V SE + +N + F Sbjct: 124 LRENLVDEIHLTRIFKNFEADVHLKSLDFSKMEKVQNAEVSSENSEIFEENGLKFEFCKW 183 Query: 157 E 157 + Sbjct: 184 K 184 >UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococcus RepID=C7REN4_ANAPD Length = 164 Score = 162 bits (411), Expect = 4e-39, Method: Composition-based stats. Identities = 45/161 (27%), Positives = 76/161 (47%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +I A+ + IG + M +++ DL FK TL IMGR T+ES+G L R+NI+ Sbjct: 1 MKIILAVDKNWGIGKDGQMLFHIRRDLKHFKSYTLGNICIMGRKTYESMGGALTHRENIV 60 Query: 62 LSSQPGTDD-RVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + ++ + E+ VIGG ++ E FL + +T I + Sbjct: 61 LSRNKDYKAKDAKVFTDYRDVLSYVRERSEEVFVIGGEKIVEIFLEYCDEAIITKIYEKK 120 Query: 120 EGDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D+ +++ DDW SE D +N S+ + R+ Sbjct: 121 DADSFLHNFDQDDDWSL--SEESDIMEENGVSFRYVRYRRK 159 >UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AYS8_STRM9 Length = 156 Score = 161 bits (409), Expect = 5e-39, Method: Composition-based stats. Identities = 51/161 (31%), Positives = 93/161 (57%), Gaps = 10/161 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI ++ A+ + IG +N M W+ +L +F++ TLN ++MG++T+ SIGRPL R+NI Sbjct: 1 MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S+ ++ + ++++D+ + D E I VIGG +Y+QFL +K+YL+ ID + Sbjct: 61 VISTTLEENEDIYVLRNIDKILEKYVDSDEIIYVIGGENIYKQFLKYTEKIYLSKIDGKF 120 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D +FP D+ + + N +++ I RR Sbjct: 121 PDADRYFPSINYDE--------YSTEVVNYNTFKLYIYTRR 153 >UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934V0_SALTI Length = 158 Score = 161 bits (409), Expect = 5e-39, Method: Composition-based stats. Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 6/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +IAA+ + IG+ N +PW P DL FK+ T N V+MGR T ES+ RPLP R N++ Sbjct: 1 MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV 60 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 L+ G + +D+ + + VIGGG++Y F+P ++++L+HI +V G Sbjct: 61 LTRSRGYIPNGFYPAGIDDVLRL---PDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVPG 117 Query: 122 -DTHFPD--YEPDDWESVFSEFHDADAQNSHSYCFEILER 158 D FP + V + + ++ + + R Sbjct: 118 ADAFFPAPMMRSLGFVPVETAYTQRANEDEPGFLQIVYRR 157 >UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaerococcus RepID=C2CJZ1_9FIRM Length = 162 Score = 161 bits (409), Expect = 6e-39, Method: Composition-based stats. Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 5/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +I A+ + IG M +++ DL FK T IMGR T+ES+G LP R+N+I Sbjct: 1 MKIILAVDKNWGIGKNGKMLFHIKKDLGHFKELTSGNICIMGRKTYESMGGALPNRENLI 60 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + + D E+ VIGG ++ E FL + +T I AE Sbjct: 61 LSRNKTYQAPDALVFNDYRDIFSYLEDKDKEVFVIGGEKIVELFLDFCDEAIITKIYAER 120 Query: 120 EGDTHFPDYEPDD-WESVFSEFHDADAQNSHSYCFEILER 158 D+ +++ DD WE + D +N S+ + + R Sbjct: 121 LADSFLHNFDSDDRWEVISK--SDIMEENGVSFQYIVYRR 158 >UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346735 n=1 Tax=Homo sapiens RepID=UPI000006EBF1 Length = 262 Score = 161 bits (408), Expect = 8e-39, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%) Query: 2 ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51 ++ I A++ + IG +PW L + +F+R T VIMG+ TW SI Sbjct: 80 LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 139 Query: 52 -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102 RPL GR N++LS + + +S+D+A+ V + ++GG VY++ Sbjct: 140 NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 199 Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFS---EFHDADAQNSHSYCFEILE 157 + KL++T I + E DT FP+ + + ++ + D + Y FE+ E Sbjct: 200 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 259 Query: 158 R 158 + Sbjct: 260 K 260 >UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SDU7_9ACTO Length = 176 Score = 160 bits (407), Expect = 9e-39, Method: Composition-based stats. Identities = 57/143 (39%), Positives = 81/143 (56%), Gaps = 6/143 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + L+ A A VIG + +PW+LP DL F+ T V+MGR TWES+ RPLPGR+ Sbjct: 3 VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGRR 62 Query: 59 NIILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N++L++ D V V++ +A D ++ VIGGGRVY FLP A ++ +T +D Sbjct: 63 NVVLTTDRSWAADGAERVDGVEDVLARTDDG-DLWVIGGGRVYAAFLPHADRVVVTDVDT 121 Query: 118 EVEGDTHFPDYEPDDWESVFSEF 140 +VEGDT P +W V Sbjct: 122 DVEGDTWAPQLGA-EWARVSRTP 143 >UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK Length = 234 Score = 160 bits (407), Expect = 1e-38, Method: Composition-based stats. Identities = 58/195 (29%), Positives = 84/195 (43%), Gaps = 39/195 (20%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I +I A D VIG MPW LP DL FK T PV+MGR +WE++ RPLP R Sbjct: 42 IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDDGFRPLPDRT 101 Query: 59 NIILSSQPGTDDRVTWVK-SVDEAIAACGD-------------------VPEIMVIGGGR 98 N +++ Q D V+ S+ A+A + P + V+GGG+ Sbjct: 102 NYVITRQDNYDAPGGIVEPSIPSALANAAEQILNELTDSADKGEGADDRTPTVWVLGGGQ 161 Query: 99 VYEQFLPKAQKLYLTHIDAE----VEGDTHFPDYEPDDWES------VFSEFHDADA--- 145 VY Q +P A ++ +T ID E + + P +++E + H D Sbjct: 162 VYAQCMPVADRIVITEIDMEAPERFQ--VYAPLVPEEEFEESAQDWQESEKGHPVDQEVD 219 Query: 146 -QNSHSYCFEILERR 159 + Y F RR Sbjct: 220 TEQPLRYRFCTWTRR 234 >UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO Length = 162 Score = 159 bits (404), Expect = 2e-38, Method: Composition-based stats. Identities = 52/159 (32%), Positives = 84/159 (52%), Gaps = 12/159 (7%) Query: 5 IAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 +AALA +RVIG + +PW ++PAD ++ + PV++GR T+ES+ LPG I++S Sbjct: 6 VAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 Query: 64 S--QPGTDDRVTWVKSVDEA--IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 + + D SV+EA IAA D VIGG +Y F P ++ L+ + E Sbjct: 66 RSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEY 125 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT++P+++ +WE H+ + + R Sbjct: 126 EGDTYYPEWDAAEWELDAETDHEG-------FTLQEWVR 157 >UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH Length = 167 Score = 159 bits (403), Expect = 3e-38, Method: Composition-based stats. Identities = 48/156 (30%), Positives = 76/156 (48%), Gaps = 8/156 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + I A+ + IG + + +P D+ +F++ TLNK V+MGR T+ES+ PL R N Sbjct: 1 MKAIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPGKEPLKDRVN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IILS + D + +SVD + +I VIGG VY Q LP + ++T + Sbjct: 61 IILSKSENIEKDGIIICRSVDGLFLELKKYNSDDIFVIGGEEVYTQLLPYCSEAHVTKFN 120 Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSY 151 D +FP+ + + W+ V + N Y Sbjct: 121 GAYSADRYFPNLDEMEGWKLVC--VGEPKEFNDIRY 154 >UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX Length = 157 Score = 158 bits (402), Expect = 4e-38, Method: Composition-based stats. Identities = 54/160 (33%), Positives = 94/160 (58%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA A + VIG +PW+ + FK T N+ +++GR T+ES+G LP RK + Sbjct: 3 VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV 61 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ T +D V S++EA+ ++ + ++V GGG +Y + LP A L+++ ID E Sbjct: 62 VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP+ P+ +E VF + ++ +YC++I ++ Sbjct: 122 PEGDVFFPNI-PNTFEVVFEQHFSSN----INYCYQIWQK 156 >UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V3M4_9FIRM Length = 322 Score = 158 bits (402), Expect = 4e-38, Method: Composition-based stats. Identities = 47/164 (28%), Positives = 66/164 (40%), Gaps = 16/164 (9%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + LIAA+ IG + + P D+A F+R T+ V+MGR T ES+ RPL GR N Sbjct: 167 LELIAAVDDAGGIGRAGHLLTDCPEDMAHFRRMTMGGIVVMGRRTMESLPGRRPLVGRMN 226 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAA-----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 I+LS D + + I VIGG Y LP + Y+T Sbjct: 227 IVLSRTMQETDGFYAAADILALWRLLGRLTAEEARPIFVIGGAACYRLLLPYVWRAYVTR 286 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + + D FP + + S FE+ ER Sbjct: 287 LLGSYDADVFFPSLD--GFSMTSSSAGQ-------DCIFEVYER 321 >UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID=Q86ZU9_COPCI Length = 205 Score = 158 bits (402), Expect = 4e-38, Method: Composition-based stats. Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 43/200 (21%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT------LNKPVIMGRHTWESIG---R 52 +++I A IG + +PW L ++ +F R T V+MGR TWESI R Sbjct: 4 LTIIVAATKANGIGKGSNLPWRLAKEMKYFARATSEAPEGTRNAVVMGRTTWESIPEKFR 63 Query: 53 PLPGRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDVP-----EIMVIGGGRV 99 PLP R N+++S + S+ + I VIGG + Sbjct: 64 PLPNRVNVVVSRNENYELEPGKEPSPMARLANSLSSGLRHLTTTDGLTVNRIFVIGGASL 123 Query: 100 YEQFL--------PKAQKLYLTHI-DAEVEGDTHFPDYEPD--DWESV----------FS 138 Y + L P ++ LT I + + + D P++ D +W FS Sbjct: 124 YRETLSLARSKTGPFVDRILLTRIVEPDFDCDVFMPEFNADGKEWTRSTHAELQEWVGFS 183 Query: 139 EFHDADAQNSHSYCFEILER 158 +N Y F++ R Sbjct: 184 VPEGIQEENGVKYEFQMWTR 203 >UniRef50_A8RBH0 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM 3991 RepID=A8RBH0_9FIRM Length = 153 Score = 158 bits (401), Expect = 5e-38, Method: Composition-based stats. Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 4/136 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++I A+ + +IG +N +PW+ P DL F R N ++MG+ T++SI L Sbjct: 1 MIAMIVAVDKNGLIGNKNRLPWHCPEDLKHFYRTIKNHELLMGKRTFDSIR--LKDNVVH 58 Query: 61 ILSSQP-GTDDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +++ Q D + + + + V GG +Y+Q P + Y++ ID E Sbjct: 59 VVTHQTIKEQDNIRICTDLSAFLKQWQTSEKTLFVCGGASIYQQAFPFCSEAYVSVIDGE 118 Query: 119 VEGDTHFPDYEPDDWE 134 +GD + P + ++ Sbjct: 119 YQGDCYLPPMDFSLFQ 134 >UniRef50_B1V8Y8 Dihydrofolate reductase n=6 Tax=Candidatus Phytoplasma RepID=B1V8Y8_PHYAS Length = 165 Score = 158 bits (401), Expect = 6e-38, Method: Composition-based stats. Identities = 46/167 (27%), Positives = 78/167 (46%), Gaps = 15/167 (8%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-----RPLP 55 MI+LI A + +IG +N +PW+ P DL +FK+ TLN+ V+MG T+ S+ +P Sbjct: 1 MINLITAFDSNYLIGSDNKLPWHYPQDLHFFKKTTLNQEVLMGHQTYLSLKSYFKDKPFN 60 Query: 56 GRKNIILSSQPGTD-DRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 +K + + G D V + + + VIGG ++Y+Q LP LY+ Sbjct: 61 FKKTYVAARNKGLQLDGCEVVFDLLTFLKTFLIQKKSHLFVIGGRQIYQQSLPFVDNLYI 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T+I +G+ +FP D++ + F +R+ Sbjct: 121 TYILNRHKGNVYFPPVNWQDFQLIQKTIQPQ-------LIFAFYKRK 160 >UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marine bacterium HF10_29C11 RepID=A4GI75_9BACT Length = 168 Score = 158 bits (400), Expect = 6e-38, Method: Composition-based stats. Identities = 51/167 (30%), Positives = 79/167 (47%), Gaps = 10/167 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNK---PVIMGRHTWESIG---RPL 54 M+ +I A+ +D IG EN +PW L +D+ FKR T+ + V+MGR TWE+I RPL Sbjct: 2 MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQGNSAVLMGRTTWETIPERFRPL 61 Query: 55 PGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLY 111 R NI+++ S++ I + E +IGG VYEQ +++ Sbjct: 62 VDRINIVVTRNRNYALSDAHVTYSIENGIEHASNNNCDECWIIGGADVYEQCRDLVDEIH 121 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LT ++ GD + D+W E + N H + IL + Sbjct: 122 LTSVETSNSGDIKVGMFG-DEWNREIIESTPESSDNEHPTTYMILRK 167 >UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=C5IWK1_ECOLX Length = 157 Score = 158 bits (400), Expect = 6e-38, Method: Composition-based stats. Identities = 42/160 (26%), Positives = 84/160 (52%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS++AA++ + VIG +PW++ + FK T N +++GR T++S+G+ LP RK + Sbjct: 3 ISIMAAVSENGVIGSGLDIPWHVQGEQLLFKAMTYNHWLLVGRKTFDSMGK-LPNRKYAV 61 Query: 62 LSSQP--GTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D V + S++ A++ + + V GGG +Y+ + +A ++L+ I Sbjct: 62 VTRSEMVSNDPDVIYFTSIESALSYLDNTTTHVFVSGGGEIYKALIEQADVIHLSVIHKH 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + GD FP P ++ F + ++ Y ++I + Sbjct: 122 ISGDVFFPSV-PQSFKQTFEQSFSSN----IDYTYQIWAK 156 >UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE Length = 462 Score = 157 bits (399), Expect = 8e-38, Method: Composition-based stats. Identities = 44/159 (27%), Positives = 83/159 (52%), Gaps = 6/159 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 S++ A+ ++ IG +N +PW L DL FK+ T VIMGR T+ES+ +PLP R N+ Sbjct: 7 FSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPLPNRVNV 66 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 ++S + + V +++A+ ++ +IGG R++E+ L K ++LT I Sbjct: 67 VISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVHLTRIGV 126 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 E + D + ++ ++ ++N +Y ++ L Sbjct: 127 ETKCDVYLNKNIFSTFQV--NKTSQTKSENGINYDYQHL 163 >UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX Length = 157 Score = 157 bits (399), Expect = 1e-37, Method: Composition-based stats. Identities = 51/160 (31%), Positives = 92/160 (57%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA++ + VIG +PW+ + FK T N+ +++GR T+ES+G LP RK + Sbjct: 3 LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV 61 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ T D+ V S+DEA+ + + ++V GGG +Y+ + K L+++ ID E Sbjct: 62 VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD +FP+ P + VFS+ ++ +Y ++I ++ Sbjct: 122 PEGDVYFPEI-PSSFRPVFSQDFVSN----INYSYQIWQK 156 >UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5RC79_WEIPA Length = 168 Score = 157 bits (398), Expect = 1e-37, Method: Composition-based stats. Identities = 51/161 (31%), Positives = 84/161 (52%), Gaps = 4/161 (2%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNII 61 +LI A +D I ++ +PW+ ADL +FK++T+++ +MGRHT S GRPLP R N++ Sbjct: 8 NLIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFHGRPLPERLNLV 67 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ + + V SV EA + ++ VIGG +YE F+ A LY+T++ + Sbjct: 68 LTRNHDLEVPEGFQKVYSVAEAEKVADNANLKLQVIGGKPIYESFMDTADTLYVTYLQTD 127 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD + W+ + ADA N + + R+ Sbjct: 128 FSGDVKMAPVDLTVWQGEVIDQGPADADNDYDWRLVKYTRQ 168 >UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD Length = 183 Score = 157 bits (398), Expect = 1e-37, Method: Composition-based stats. Identities = 59/181 (32%), Positives = 87/181 (48%), Gaps = 25/181 (13%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 M+ I A + D VIG++ +PW+L DL +F R T+ PVIMGR TWES RPLPGR Sbjct: 1 MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPEQFRPLPGR 60 Query: 58 KNIILSSQPGT----DDRVTWVKSVDEAIAAC------------GDVPEIMVIGGGRVYE 101 NI+++S+P + +RV V S EA+ E+ VIGG V+ Sbjct: 61 PNIVITSRPESVPADGERVWAVGSYAEALELAVSLLAAPGPEHEEPAREVWVIGGPGVWR 120 Query: 102 QFLPK----AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 + + + +T +D +V GDTH P + W +A+N + + Sbjct: 121 EAVSHRPLPLTRALVTTVDLDVTGDTHAPALDGS-WSR-REVAGWTEARNGTWFRIDEWT 178 Query: 158 R 158 R Sbjct: 179 R 179 >UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_HUMAN Length = 187 Score = 157 bits (397), Expect = 1e-37, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%) Query: 2 ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51 ++ I A++ + IG +PW L + +F+R T VIMG+ TW SI Sbjct: 5 LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 64 Query: 52 -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102 RPL GR N++LS + + +S+D+A+ V + ++GG VY++ Sbjct: 65 NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 124 Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFS---EFHDADAQNSHSYCFEILE 157 + KL++T I + E DT FP+ + + ++ + D + Y FE+ E Sbjct: 125 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 184 Query: 158 R 158 + Sbjct: 185 K 185 >UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim resistance) n=2 Tax=Vibrio splendidus RepID=B7VPW7_VIBSL Length = 183 Score = 157 bits (397), Expect = 1e-37, Method: Composition-based stats. Identities = 50/160 (31%), Positives = 89/160 (55%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA+A + VIG +PW + + FK T N+ +++GR T+ES+G+ LP RK + Sbjct: 29 LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAV 87 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S P T D + + KSV++A+ V E V GGG++Y+ + + ++++ I Sbjct: 88 ISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKH 147 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + GD FP+ P D VF + ++ Y ++I ++ Sbjct: 148 ISGDIFFPEL-PRDLTLVFEQRFSSN----IDYTYQIWQK 182 >UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus RepID=DYR_LACCA Length = 163 Score = 156 bits (396), Expect = 2e-37, Method: Composition-based stats. Identities = 45/163 (27%), Positives = 81/163 (49%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M + + A D +IG + +PW+LP DL +F+ T+ K +++GR T+ES RPLP R N Sbjct: 1 MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN 60 Query: 60 IILSSQPGTDDRV---TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++L+ Q + + A A E+++ GG +++ F L +T + Sbjct: 61 VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGDT DD+ V S + D + ++ +E+ +++ Sbjct: 121 GSFEGDTKMIPLNWDDFTKVSSRTVE-DTNPALTHTYEVWQKK 162 >UniRef50_Q6CC38 YALI0C12771p n=1 Tax=Yarrowia lipolytica RepID=Q6CC38_YARLI Length = 189 Score = 156 bits (395), Expect = 2e-37, Method: Composition-based stats. Identities = 58/182 (31%), Positives = 87/182 (47%), Gaps = 27/182 (14%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTL---NKPVIMGRHTWESIG---RPLPGR 57 ++AA IG+ +PW L ++ +FK+ T N VIMGR TW+SI RPLP R Sbjct: 8 ILAATVPRYGIGLNGGLPWRLAKEMKFFKQVTTAQKNAVVIMGRTTWDSIPPKFRPLPDR 67 Query: 58 KNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLT 113 NI+L+S+P TD + V +S DEA+ C + + VIGG +VY+ L + + LT Sbjct: 68 TNIVLTSRPMTDAPEEVVVARSFDEALTKCPEDSTVYVIGGSQVYKTALVHEHTKAVLLT 127 Query: 114 HI---DAEVEGDTHFPDYEPDDWESVFSEFHD--------------ADAQNSHSYCFEIL 156 I D VE DT F ++ W+ E + S+ + + Sbjct: 128 EITCPDGHVECDTFFEGFDQGLWKKQPYERLQDFVGDKVELPGRDTPVEEKGFSFVYTLW 187 Query: 157 ER 158 E+ Sbjct: 188 EK 189 >UniRef50_A6DQ18 Dihydrofolate reductase region n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DQ18_9BACT Length = 149 Score = 156 bits (395), Expect = 3e-37, Method: Composition-based stats. Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 11/159 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+SLI+A+ + +IG A+PW + + + K +I+GR T+E G L + Sbjct: 1 MLSLISAMDKNGLIGTGKALPWKVEEEYQRYLDTVKGKKIIVGRKTFEISGLDLKDEQVH 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ILSS+ + ++++AI ACG+ +I V GG VY+ +P A +LY++ I + E Sbjct: 61 ILSSRSQ---GTNYYNNIEDAIKACGE-NDIFVTGGAEVYKLAMPHADRLYISVIKGDYE 116 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 G +FP+ + + WE E Y + I ++ Sbjct: 117 GSIYFPNIDANIWEVQHHEELPE-------YDYYIYRKK 148 >UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017450E9 Length = 179 Score = 155 bits (394), Expect = 3e-37, Method: Composition-based stats. Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 7/162 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 ++LIAA+ + ++ +PW LP D+A F+ K +++GRHT+E + G P + + Sbjct: 8 LTLIAAVDENLLLATAQGIPWKLPDDVAHFRAYCAGKWLLLGRHTYEDMTGWFKPDQHPL 67 Query: 61 ILSSQPGTDDR-VTWVKSVDEAIAA--CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+S G + V SV +A+A E++ IGGG+V+ LP A +L +THI Sbjct: 68 VLTSTCGYEPNPGRGVASVPQALALAEAEGQEELVCIGGGQVFATALPHATRLVITHIKH 127 Query: 118 EVE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 E GD +FP D W H D +++ + F Sbjct: 128 IFEPGDQPVYFPPISADAWREERRLDHAVDDRHAWPFTFVEY 169 >UniRef50_P16184 Dihydrofolate reductase n=38 Tax=Pneumocystis RepID=DYR_PNECA Length = 206 Score = 154 bits (391), Expect = 7e-37, Method: Composition-based stats. Identities = 55/198 (27%), Positives = 88/198 (44%), Gaps = 41/198 (20%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT----------LNKPVIMGRHTWESIG 51 ++LI AL IG N++PW L ++++FKR T V+MGR TWESI Sbjct: 7 LTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIP 66 Query: 52 ---RPLPGRKNIILSSQPGTD--DRVTWVKSVDEAIAAC---------GDVPEIMVIGGG 97 RPL GR N++++ D + + KS+D A+ + I VIGG Sbjct: 67 LQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGA 126 Query: 98 RVYEQFL--PKAQKLYLTHIDAEVEGDTHFP-DYEPDDWESVFSEF-------------- 140 ++Y+ + PK ++ T I ++ D FP + +W SV+ + Sbjct: 127 QLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVP 186 Query: 141 HDADAQNSHSYCFEILER 158 H ++ Y FE+ R Sbjct: 187 HGKINEDGFDYEFEMWTR 204 >UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli RepID=DYR9_ECOLX Length = 177 Score = 154 bits (391), Expect = 8e-37, Method: Composition-based stats. Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 11/164 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +++I A+ IG EN +PW+ P DL FK T+N +IMGR T+ S+ + LPGR +++ Sbjct: 4 LNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRLHVV 63 Query: 62 LSSQ---PGTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYL 112 +S D+V +V + A+ + +I VIGG YE KLYL Sbjct: 64 VSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDKLYL 123 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 T + + DT W+ V +N F+I Sbjct: 124 TRVQLNTQQDTELDLSLFKSWKLVSEV--PTITENKTKLIFQIW 165 >UniRef50_D2NRG7 Dihydrofolate reductase n=2 Tax=Rothia mucilaginosa RepID=D2NRG7_9MICC Length = 222 Score = 153 bits (388), Expect = 2e-36, Method: Composition-based stats. Identities = 63/216 (29%), Positives = 82/216 (37%), Gaps = 59/216 (27%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + I A +IG MPW P DLA FK+ TL PVIMGR TWES RPLPGR Sbjct: 5 LGAIWAQTDAGIIGRAGDMPWYAPEDLAHFKKVTLGAPVIMGRRTWESFPPRFRPLPGRT 64 Query: 59 NIILSSQ---PGTDDRVTWVKSVDEAIAACGD------------------VPEIMVIGGG 97 NI++S D WV S+D A+ A D + +IGGG Sbjct: 65 NIVISRSVTEAEERDGALWVPSLDAALYAARDAVGAPVEATPADTATDAPAVDAWIIGGG 124 Query: 98 RVYEQFLPKAQ------------KLYLTHIDAEVEGDTHFPDYEPDD------------- 132 VY + L + L+ E+ GDT P+ + D Sbjct: 125 SVYAEALSRNDLPAFGRVKTVERTLFYCQEGNEITGDTRAPELQLADSHGNCATGSPNGC 184 Query: 133 WESVFSEFHDADA----------QNSHSYCFEILER 158 W V + +N + F+ LER Sbjct: 185 WHVVSETAWEKSEKGYLLDESGTKNPMYFSFQRLER 220 >UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A8SSS6_9FIRM Length = 168 Score = 153 bits (388), Expect = 2e-36, Method: Composition-based stats. Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 8/162 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + IAA+ + IG + ++ + D F++ T+ V++GR T E RPL GR N Sbjct: 1 MKFIAAVDNNWAIGNKGSLLVRISEDQKNFRKETMGHVVVLGRKTLEEFPGGRPLKGRTN 60 Query: 60 IILSSQPGTDD-RVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116 IILS+ P V S+DE + +I +IGG VY+ +P +T ID Sbjct: 61 IILSTNPDYTVQDAVVVHSIDELFEKLSEYESDDIFIIGGQTVYDVLIPYCDTGIVTKID 120 Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILE 157 E D + + D+W N + F + Sbjct: 121 KSYEADAFIQNLDEMDNWHV--ENERSGTEPNDVNITFVTYK 160 >UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX Length = 157 Score = 153 bits (387), Expect = 2e-36, Method: Composition-based stats. Identities = 48/160 (30%), Positives = 92/160 (57%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI+A + + VIG +PW+ + FK T N+ +++GR T++S+G LP RK + Sbjct: 3 ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61 Query: 62 LSSQ--PGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S + +++ V S++ A+ + + + V GGG++Y + KA ++L+ + E Sbjct: 62 VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGD +FP P+++ VF +F ++ +Y ++I ++ Sbjct: 122 VEGDINFPKI-PENFNLVFEQFFLSN----INYTYQIWKK 156 >UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY Length = 160 Score = 152 bits (386), Expect = 2e-36, Method: Composition-based stats. Identities = 60/167 (35%), Positives = 85/167 (50%), Gaps = 20/167 (11%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M+ I A + +IG +MPW++P DL FK+ TL P+IMGR TWES+ RPLPGRKN Sbjct: 1 MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPVRPLPGRKN 60 Query: 60 IILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++LS + + + + SV E+ VIGGG VY + K Q+++ T IDA Sbjct: 61 LVLSRRTPGKWSNGASVIASVPES---------GWVIGGGVVYAATIDKVQEIHRTLIDA 111 Query: 118 E---VE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E GD P PD ++ V + + Y FE + Sbjct: 112 PTNLFELGDRAVFAPTIPPD-FQLVQHSKWLKSS-SGLRYKFETWTK 156 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepI... 228 5e-59 UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2 223 1e-57 UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD 219 3e-56 UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistip... 218 5e-56 UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteria... 217 1e-55 UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteoba... 217 1e-55 UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05... 216 2e-55 UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D... 213 2e-54 UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria R... 213 2e-54 UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobact... 212 3e-54 UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD 209 2e-53 UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacte... 209 2e-53 UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacte... 208 5e-53 UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burneti... 208 5e-53 UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria ... 208 6e-53 UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobact... 206 1e-52 UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium j... 206 2e-52 UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6 206 2e-52 UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lit... 205 4e-52 UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacte... 204 6e-52 UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium... 204 6e-52 UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=... 204 1e-51 UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria ... 203 2e-51 UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacter... 203 2e-51 UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes R... 202 3e-51 UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacill... 202 3e-51 UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacte... 201 6e-51 UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales... 201 7e-51 UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=... 201 8e-51 UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succ... 200 1e-50 UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria R... 200 1e-50 UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanth... 200 2e-50 UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q... 199 2e-50 UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter no... 199 2e-50 UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium ... 199 2e-50 UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pin... 199 3e-50 UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved... 198 4e-50 UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accum... 198 6e-50 UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobact... 198 7e-50 UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus Re... 197 9e-50 UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q... 197 9e-50 UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales ... 197 9e-50 UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus rube... 197 1e-49 UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q... 197 1e-49 UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=... 197 1e-49 UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria ... 197 1e-49 UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A... 196 1e-49 UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria ... 196 1e-49 UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methyloph... 196 2e-49 UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter Rep... 196 2e-49 UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp... 196 2e-49 UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni ... 196 3e-49 UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella ... 195 4e-49 UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobact... 194 5e-49 UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonel... 194 6e-49 UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri... 194 6e-49 UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesic... 194 9e-49 UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q... 194 1e-48 UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax parad... 193 2e-48 UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endorifti... 193 2e-48 UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchi... 193 2e-48 UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staley... 193 2e-48 UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=D... 193 2e-48 UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus Re... 192 3e-48 UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organi... 192 3e-48 UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobact... 192 4e-48 UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepI... 192 4e-48 UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae ... 191 4e-48 UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobia... 191 4e-48 UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C... 191 5e-48 UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae R... 191 5e-48 UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria R... 191 7e-48 UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp.... 191 9e-48 UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonel... 189 2e-47 UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteob... 189 3e-47 UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm... 189 3e-47 UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter... 189 3e-47 UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus Re... 188 7e-47 UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organis... 187 1e-46 UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales Re... 187 1e-46 UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candida... 187 1e-46 UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica... 186 2e-46 UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella mult... 186 2e-46 UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae ... 186 2e-46 UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus R... 185 4e-46 UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiace... 185 4e-46 UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter ferm... 185 5e-46 UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris ... 184 6e-46 UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium Rep... 184 7e-46 UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomi... 184 7e-46 UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas su... 184 7e-46 UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=D... 184 1e-45 UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales R... 183 1e-45 UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadacea... 183 2e-45 UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. ... 182 3e-45 UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus Re... 182 3e-45 UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio ac... 181 5e-45 UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobac... 181 5e-45 UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 181 6e-45 UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepI... 181 6e-45 UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella Rep... 181 8e-45 UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. ... 181 9e-45 UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobi... 180 1e-44 UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azoba... 180 1e-44 UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales... 180 1e-44 UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus ... 179 2e-44 UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacte... 179 2e-44 UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepI... 178 5e-44 UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macroco... 178 7e-44 UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales ... 177 9e-44 UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q... 177 1e-43 UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter... 177 1e-43 UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacte... 176 2e-43 UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus R... 176 2e-43 UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococ... 176 2e-43 UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 176 2e-43 UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae... 175 3e-43 UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepI... 175 3e-43 UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus ... 175 4e-43 UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID... 175 5e-43 UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate... 175 5e-43 UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicade... 174 6e-43 UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus Re... 174 6e-43 UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacte... 174 7e-43 UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales ... 174 9e-43 UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepI... 174 1e-42 UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus Re... 174 1e-42 UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gam... 173 1e-42 UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas... 173 2e-42 UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp.... 173 2e-42 UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin5... 173 2e-42 UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perf... 172 3e-42 UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri... 172 4e-42 UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales ... 171 5e-42 UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula mar... 171 6e-42 UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=... 171 7e-42 UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae R... 171 9e-42 UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidat... 170 1e-41 UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perf... 169 2e-41 UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella berge... 169 2e-41 UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis... 169 2e-41 UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas ue... 169 2e-41 UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Ba... 169 3e-41 UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase ... 169 4e-41 UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate red... 168 4e-41 UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saph... 168 4e-41 UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus R... 168 4e-41 UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae... 168 5e-41 UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus Re... 168 5e-41 UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C... 167 7e-41 UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacter... 167 8e-41 UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis viresc... 167 9e-41 UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus fae... 167 1e-40 UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter form... 167 1e-40 UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium v... 167 1e-40 UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium ... 166 2e-40 UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepI... 166 2e-40 UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales... 166 2e-40 UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebac... 166 2e-40 UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus fa... 166 2e-40 UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID... 166 2e-40 UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella mult... 165 4e-40 UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia ... 165 4e-40 UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus Re... 165 4e-40 UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Cl... 164 6e-40 UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolys... 164 6e-40 UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deutero... 164 6e-40 UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula b... 164 9e-40 UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium ... 164 1e-39 UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopisc... 164 1e-39 UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cell... 164 1e-39 UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stella... 163 2e-39 UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidic... 163 2e-39 UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbi... 163 2e-39 UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacte... 163 2e-39 UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (... 163 2e-39 UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muci... 162 3e-39 UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrif... 162 3e-39 UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuring... 162 3e-39 UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=... 162 4e-39 UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae Re... 162 4e-39 UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatu... 161 6e-39 UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum ... 161 7e-39 UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346... 161 9e-39 UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales... 161 9e-39 UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organis... 160 1e-38 UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorh... 159 2e-38 UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloac... 159 2e-38 UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobact... 159 3e-38 UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi... 159 3e-38 UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin... 159 3e-38 UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcacea... 159 3e-38 UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xen... 159 4e-38 UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacte... 158 4e-38 UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena tu... 157 7e-38 UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira h... 157 9e-38 UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepI... 157 1e-37 UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota R... 157 1e-37 UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacte... 157 1e-37 UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichop... 157 1e-37 UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_... 157 1e-37 UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypotheti... 156 2e-37 UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacteriu... 156 3e-37 UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium ... 156 3e-37 UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococ... 155 3e-37 UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus co... 155 4e-37 UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadacea... 155 4e-37 UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus R... 155 4e-37 UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobact... 155 4e-37 UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocace... 154 8e-37 UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mans... 154 8e-37 UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaeroc... 154 1e-36 UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostri... 153 2e-36 UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax... 153 2e-36 UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniob... 152 3e-36 UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphoki... 152 4e-36 UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cav... 152 4e-36 UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix r... 152 5e-36 UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root R... 152 5e-36 UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepI... 151 5e-36 UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus... 151 5e-36 UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmone... 151 6e-36 UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX6... 151 6e-36 UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reduc... 151 7e-36 UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure... 151 9e-36 UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter lito... 150 1e-35 UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea vi... 150 1e-35 UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus Re... 149 2e-35 UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=... 149 2e-35 UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatu... 148 5e-35 UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella parame... 148 5e-35 UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales ... 148 5e-35 UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria... 147 8e-35 UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinom... 147 9e-35 UniRef50_C2D6N3 Possible dihydrofolate reductase n=1 Tax=Atopobi... 147 1e-34 UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID... 147 1e-34 UniRef50_UPI000180BE95 PREDICTED: similar to GJ10259 n=1 Tax=Cio... 147 1e-34 UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim res... 146 2e-34 UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marin... 146 3e-34 UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherich... 146 3e-34 UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptoba... 146 3e-34 UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteri... 145 4e-34 UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria... 145 4e-34 UniRef50_Q53D67 JM3 n=3 Tax=Macacine herpesvirus 5 RepID=Q53D67_... 145 5e-34 UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae... 145 5e-34 UniRef50_Q4SM73 Chromosome 13 SCAF14555, whole genome shotgun se... 144 8e-34 UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimo... 144 8e-34 UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium ... 144 8e-34 UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetr... 144 1e-33 UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=... 144 1e-33 Sequences not found previously or not previously below threshold: >UniRef50_P11045 Dihydrofolate reductase n=23 Tax=Firmicutes RepID=DYR_BACSU Length = 168 Score = 228 bits (582), Expect = 5e-59, Method: Composition-based stats. Identities = 70/160 (43%), Positives = 102/160 (63%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A+ +R+IG +N +PW+LP DLA+FK+ T +IMGR T+ESIGRPLP RKNI Sbjct: 1 MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++S P ++ T V S+ + + C E VIGG ++Y P A +LY+T I E Sbjct: 61 VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD HFP+++ +W+ V SE D +N + Y F + E++ Sbjct: 121 EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK 160 >UniRef50_A7Z5T2 DfrA n=2 Tax=Bacillaceae RepID=A7Z5T2_BACA2 Length = 161 Score = 223 bits (569), Expect = 1e-57, Method: Composition-based stats. Identities = 59/160 (36%), Positives = 91/160 (56%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A+ +R+IG +N +PW+LP DLA+FK+ T ++MGR T+ESIGRPLP R+NI Sbjct: 1 MISFIFAMDENRLIGKDNDLPWHLPDDLAYFKKVTTGHTIVMGRKTFESIGRPLPNRRNI 60 Query: 61 ILS-SQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ + S +E + E VIGG ++Y P A +LY+T I Sbjct: 61 VVTSRDESSFPGCITADSAEEVLKLIPADEECFVIGGAQLYSALFPYADRLYMTKIHHVF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP++ +WE + D +N + Y + + E++ Sbjct: 121 EGDRFFPEFNEAEWELTSRKQGVKDEKNPYDYEYLVYEKK 160 >UniRef50_Q65IB5 DfrA n=4 Tax=Bacillaceae RepID=Q65IB5_BACLD Length = 162 Score = 219 bits (558), Expect = 3e-56, Method: Composition-based stats. Identities = 71/161 (44%), Positives = 98/161 (60%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAA+ +R+IG +N +PW+LP DL +FK T VIMGR T+ESIGRPLP R+NI Sbjct: 1 MISLIAAMDRNRLIGKDNDLPWHLPQDLKYFKEVTKGHAVIMGRKTFESIGRPLPHRENI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 I++S D + S +EA+ + E VIGG +Y + LP A KLY+T ID Sbjct: 61 IVTSNKELDIPNCQVMHSAEEAVRFAKNRNEECFVIGGSTLYTEILPFADKLYVTKIDET 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD +FP++ +WE V D +N + Y F + +R+ Sbjct: 121 FEGDRYFPEFSEAEWEIVSRRKGLKDDKNPYDYEFLVYQRK 161 >UniRef50_B0MUX5 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MUX5_9BACT Length = 160 Score = 218 bits (556), Expect = 5e-56, Method: Composition-based stats. Identities = 62/159 (38%), Positives = 97/159 (61%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++I A+A + VIG +N + W++ DL FK T PV+MGR T+ES+GRPLPGR+N+ Sbjct: 1 MIAIIVAVAENGVIGGDNRLLWHISEDLKHFKAVTTGHPVVMGRKTYESLGRPLPGRRNV 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +++ Q + + V S+DEA+A ++ VIGG ++Y Q LP + YLT + + Sbjct: 61 VVTRQNISIEGCDVVHSLDEALALFRPEEKVFVIGGAQIYAQALPLCDEFYLTRVFHAYQ 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP ++ +WE + SE + + + + FE RR Sbjct: 121 GDTCFPRWDEREWEIIDSESFASGKEFPYPFAFEHYRRR 159 >UniRef50_P0ABQ5 Dihydrofolate reductase n=111 Tax=Enterobacteriaceae RepID=DYR_ECOL6 Length = 159 Score = 217 bits (553), Expect = 1e-55, Method: Composition-based stats. Identities = 159/159 (100%), Positives = 159/159 (100%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI Sbjct: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE Sbjct: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Sbjct: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 >UniRef50_P12833 Dihydrofolate reductase type 3 n=26 Tax=Proteobacteria RepID=DYR3_SALTY Length = 162 Score = 217 bits (553), Expect = 1e-55, Method: Composition-based stats. Identities = 82/160 (51%), Positives = 112/160 (70%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAALA + +IG +N +PW+LPADL FK TL KPV+MGR T+ESIGRPLPGR+N+ Sbjct: 2 LISLIAALAHNNLIGKDNLIPWHLPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNV 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S P + V S+D A+A D E M+IGGG++Y + LP+A +LYLT+IDA++ Sbjct: 62 VVSRNPQWQAEGVEVAPSLDAALALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQL 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDY W+ + H AD +NS++ F L R+ Sbjct: 122 NGDTHFPDYLSLGWQELERSTHPADDKNSYACEFVTLSRQ 161 >UniRef50_D0U4K0 Dihydrofolate reductase n=2 Tax=uncultured SUP05 cluster bacterium RepID=D0U4K0_9GAMM Length = 179 Score = 216 bits (551), Expect = 2e-55, Method: Composition-based stats. Identities = 72/158 (45%), Positives = 102/158 (64%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ +++IG NA+PW+LPADL +FK+ T K V+MGR T+ESIGRPLP R+N+I Sbjct: 21 LSIIVAMDDNQLIGKNNALPWHLPADLGYFKKVTTGKTVLMGRKTYESIGRPLPNRRNVI 80 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S+D A+ D E+MV+GG YEQ LP +LY+T I+ E + Sbjct: 81 VSRNTNFKADGCEVVSSIDAALKLAKDDSEVMVMGGASFYEQMLPSVDRLYITQIEGEYQ 140 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD HFP ++ + V E H AD +N ++Y F IL+R Sbjct: 141 GDAHFPKFDRGKFSEVSRESHTADEKNQYTYHFTILDR 178 >UniRef50_D2QJY0 Dihydrofolate reductase n=2 Tax=Bacteria RepID=D2QJY0_9SPHI Length = 163 Score = 213 bits (542), Expect = 2e-54, Method: Composition-based stats. Identities = 71/160 (44%), Positives = 103/160 (64%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLIAA+A + VIG EN +PW+LP D A+FKR T + P+IMGR + ES+G+PLP R NI+ Sbjct: 3 ISLIAAVAQNGVIGRENDLPWHLPDDFAFFKRKTSHHPIIMGRKSLESLGKPLPNRTNIV 62 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ VT V ++D+AIA + EI VIGG +Y+ LP A LYLT I + Sbjct: 63 LTRNAEFSAAGVTIVHTLDDAIAEAKAINQTEIFVIGGAEIYKMALPIATTLYLTEIHQD 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD +FP+++ ++W+ V H AD +++ S+ F E+ Sbjct: 123 YDGDAYFPEFDKNEWQEVSRRPHPADERHAVSFDFVEYEK 162 >UniRef50_Q1LK80 Dihydrofolate reductase n=3 Tax=Proteobacteria RepID=Q1LK80_RALME Length = 166 Score = 213 bits (542), Expect = 2e-54, Method: Composition-based stats. Identities = 66/159 (41%), Positives = 92/159 (57%), Gaps = 2/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +++LI A A + VIG N +PW LP DL FKR T+ P+IMGR TW+SIGRPLPGR+NI Sbjct: 3 LLTLIVARARNGVIGRNNTLPWRLPEDLQHFKRTTMGAPIIMGRKTWDSIGRPLPGRRNI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ + V S+++A C ++ +IGG ++Y + LP A +L +T IDA+V Sbjct: 63 VVTRNRDLHIEGADVVGSIEDAQRLCIGAEQVFLIGGAQLYAEALPSADRLIVTEIDADV 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP + W E H N Y F ER Sbjct: 123 EGDAFFPAVDRTTWVETARELH-HSETNGFDYAFVTYER 160 >UniRef50_P27498 Dihydrofolate reductase n=89 Tax=Gammaproteobacteria RepID=DYR_KLEAE Length = 159 Score = 212 bits (540), Expect = 3e-54, Method: Composition-based stats. Identities = 142/159 (89%), Positives = 152/159 (95%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLIAAL VDRVIGMENAMPWNL DLAWFKRNTLNKPV+MGR TWESIGRPLPGRKNI Sbjct: 1 MISLIAALRVDRVIGMENAMPWNLNEDLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++SS+PG+DDRV WV SV+EAIAACGDV EIMVIGGGRVY++FLPKAQKLYLTHIDAEVE Sbjct: 61 VISSKPGSDDRVQWVSSVEEAIAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVE 120 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDTHFPDY+PD+WESVFSEFHDADAQNSHSYCFEILERR Sbjct: 121 GDTHFPDYDPDEWESVFSEFHDADAQNSHSYCFEILERR 159 >UniRef50_A9I779 FolA protein n=2 Tax=Bordetella RepID=A9I779_BORPD Length = 178 Score = 209 bits (534), Expect = 2e-53, Method: Composition-based stats. Identities = 69/159 (43%), Positives = 95/159 (59%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A + +RVIG +N +PW LP DLA FKR TL P+IMGR TWES+GRPLPGR N++ Sbjct: 21 LTLVVAYSDNRVIGRDNTLPWKLPGDLAHFKRTTLGSPIIMGRKTWESLGRPLPGRTNVV 80 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S T V ++ A+ ACGD P+ VIGG ++Y Q LP A ++ T + A VE Sbjct: 81 ISRNLRYAAPGATVVPTLQAAVEACGDAPDAYVIGGAQIYAQALPLAARVIATEVHAHVE 140 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP W + A +N + Y F + ER+ Sbjct: 141 GDAFFPYLPSFAWREASRQPQPA--ENGYDYDFVVYERQ 177 >UniRef50_A1U3D7 Dihydrofolate reductase n=6 Tax=Gammaproteobacteria RepID=A1U3D7_MARAV Length = 171 Score = 209 bits (533), Expect = 2e-53, Method: Composition-based stats. Identities = 69/164 (42%), Positives = 100/164 (60%), Gaps = 8/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 +LI A+A +RVIG N +PW LP DL +FK+ T+ KP+IMGR TW+SIGRPLPGR N+++ Sbjct: 4 ALIVAMARNRVIGRNNKLPWYLPGDLRYFKQATMGKPIIMGRKTWDSIGRPLPGRMNVVI 63 Query: 63 SSQP--GTDDRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 S P S++EA+ A E+M+IGGG++Y + LP ++Y+T Sbjct: 64 SRNPEWQAPAGTVAAASLNEALVKAEAQANLEGGDEVMIIGGGQIYAEALPMVDRIYITQ 123 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + AEV+GD FP+ D+WE + E A N + Y F + +R Sbjct: 124 VHAEVDGDAFFPEVNWDEWEEIGREDFSASDNNPYDYSFVVYQR 167 >UniRef50_D0KZ69 Dihydrofolate reductase n=2 Tax=Gammaproteobacteria RepID=D0KZ69_HALNC Length = 177 Score = 208 bits (530), Expect = 5e-53, Method: Composition-based stats. Identities = 82/159 (51%), Positives = 104/159 (65%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+AAL ++VIG NA+PW+LPADL FK+ T+ KP+IMGR T++SIGRPLPGRKNI+ Sbjct: 3 IGLVAALTRNQVIGRYNALPWSLPADLQRFKKITMGKPIIMGRKTYDSIGRPLPGRKNIV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 +S P D VT V S+D A+ A PE+MVIGG +Y QFLP+A +LY T + + Sbjct: 63 ISRNPDFHADGVTVVDSLDMALEAADQAPEVMVIGGANIYYQFLPRADRLYFTLVHTTID 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD FP Y DW V E H ADA N Y F +R Sbjct: 123 DGDAFFPAYNRRDWRLVIEENHPADADNPFPYSFMTWQR 161 >UniRef50_A9KH09 Dihydrofolate reductase n=8 Tax=Coxiella burnetii RepID=A9KH09_COXBN Length = 161 Score = 208 bits (530), Expect = 5e-53, Method: Composition-based stats. Identities = 67/159 (42%), Positives = 106/159 (66%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +I+LIAA+ +R+IG N +PW+LPADLA FK TL KP++MGR T++SIG+PLP R+NI Sbjct: 2 IITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNI 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ Q + S+D+A++A PE+++IGG R++++ LPKA K+ LT I+ Sbjct: 62 VITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD +FP++ +W+ H+ D +N + + F L R Sbjct: 122 EGDVYFPEWNDKEWKITSQIKHERDEKNPYPFQFLELRR 160 >UniRef50_A4Y040 Dihydrofolate reductase n=28 Tax=Proteobacteria RepID=A4Y040_PSEMY Length = 176 Score = 208 bits (530), Expect = 6e-53, Method: Composition-based stats. Identities = 79/165 (47%), Positives = 103/165 (62%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAALA +RVIG +N +PW+LPADL FK TL KP+IMGR TW+S+GRPLPGR NI+ Sbjct: 11 LSLIAALADNRVIGRDNQLPWHLPADLKHFKALTLGKPIIMGRKTWDSLGRPLPGRLNIV 70 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S Q G T + +++EAI D E+M+IGG ++YE L +A +LYLT Sbjct: 71 VSRQAGLTLEGAEVFATLEEAIKRADAWAREEDAEELMLIGGAQLYELGLEQADRLYLTR 130 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + E EGD FP + W S H A A+ Y FE+ ERR Sbjct: 131 VGLEPEGDAFFPQIDESAWRMTSSVEHPASAETPF-YAFEVWERR 174 >UniRef50_P43791 Dihydrofolate reductase n=19 Tax=Gammaproteobacteria RepID=DYR_HAEIN Length = 160 Score = 206 bits (526), Expect = 1e-52, Method: Composition-based stats. Identities = 84/158 (53%), Positives = 107/158 (67%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 SLI A ++ VIG +N MPW+LPADLAWF++NT KPVIMGR T+ESIGRPLP R NI+ Sbjct: 3 FSLIVATTLNNVIGKDNQMPWHLPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIV 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 LS Q + V W S + A+ D EIM+IGGG +++Q+LPKA KLYLT I E++G Sbjct: 63 LSRQLFEHEGVIWKDSFESAVNFVRDFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDG 122 Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DT FP ++WE F E+ AD QN + F IL R+ Sbjct: 123 DTFFPQLNWEEWEIEFDEYRKADEQNRYDCRFLILTRK 160 >UniRef50_A5FJX2 Dihydrofolate reductase n=1 Tax=Flavobacterium johnsoniae UW101 RepID=A5FJX2_FLAJ1 Length = 160 Score = 206 bits (526), Expect = 2e-52, Method: Composition-based stats. Identities = 59/160 (36%), Positives = 90/160 (56%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI +IAA+A + +G N + W+LP D FK T N +IMGR T+ES +PLP R +I Sbjct: 1 MIIMIAAVAENNTLGKNNELVWHLPNDFKRFKSLTTNHHIIMGRKTFESFPKPLPNRTHI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ Q + V S+++AIAAC + + +IGGG +Y LP A + +T + Sbjct: 61 IITRQTDYNPEGCIVVDSMEKAIAACPENEDSYIIGGGEIYNLGLPYADIIEITKVHHTF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP +W+ V SE + D ++ + Y +E R+ Sbjct: 121 EGDAFFPKISKSEWQLVESEENFKDEKHLYDYTYETYIRK 160 >UniRef50_A0AJX9 DfrA protein n=15 Tax=Listeria RepID=A0AJX9_LISW6 Length = 160 Score = 206 bits (525), Expect = 2e-52, Method: Composition-based stats. Identities = 60/159 (37%), Positives = 90/159 (56%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG +N MPW+LP DL +FK+ T K ++MGR T+ES+G+ LP RK I Sbjct: 1 MIIFVWAQDRAGNIGKDNTMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ D + S +E +A I V+GG +Y F+ A KL +T IDAE Sbjct: 61 VLTRDKELQLDDAEILHSREEVLALTQTGEPIYVVGGAEIYRLFMDVADKLIVTKIDAEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + DT FP+ + +++ + E H+ D +N ++Y F ER Sbjct: 121 DADTAFPEVDWENFSEIAKEPHEKDEKNKYNYTFYTYER 159 >UniRef50_C6P459 Dihydrofolate reductase n=1 Tax=Sideroxydans lithotrophicus ES-1 RepID=C6P459_9PROT Length = 177 Score = 205 bits (522), Expect = 4e-52, Method: Composition-based stats. Identities = 54/158 (34%), Positives = 83/158 (52%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLI A+A +R IG+ N +PW P DL FK T+ +IMGR T++SIG+PLPGR ++ Sbjct: 19 LSLIVAMARNRTIGVNNTLPWRCPEDLKHFKTLTMGHHMIMGRKTFDSIGKPLPGRTTVV 78 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + + S+ EA+ C EI V+GG +Y Q + LY+T I +V Sbjct: 79 ITRNNDLEIEGCIVAHSLQEALVTCAGDEEIFVVGGAELYRQAISLVDTLYVTEIQQDVA 138 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD HFP+ + W+ E + + F + Sbjct: 139 GDAHFPEIDKAFWQETSREMRSQETPQPMDFHFVTYRK 176 >UniRef50_Q3JEI1 Dihydrofolate reductase n=3 Tax=Gammaproteobacteria RepID=Q3JEI1_NITOC Length = 165 Score = 204 bits (521), Expect = 6e-52, Method: Composition-based stats. Identities = 71/159 (44%), Positives = 103/159 (64%), Gaps = 1/159 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS I A+ + +IG +PW+LPADL +F+R T+ KP++MGR T E+IGRPLPGR NI Sbjct: 2 IISFIVAMDENHLIGANRRLPWHLPADLKYFRRMTMGKPMLMGRSTHEAIGRPLPGRHNI 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ P T V +V+ + A G+ E+ VIGG +YEQ LP+A+++YLT + Sbjct: 62 VVTHNPDYKAPGCTVVHTVEAGLQAAGEAEEVTVIGGASLYEQLLPQARRIYLTLVRGHF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GDT FP ++P W V+ E +D D QN + Y F LER Sbjct: 122 QGDTWFPAFDPGTWVEVWREDYDPDPQNPYPYSFIRLER 160 >UniRef50_C2FZ23 Dihydrofolate reductase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZ23_9SPHI Length = 164 Score = 204 bits (521), Expect = 6e-52, Method: Composition-based stats. Identities = 70/159 (44%), Positives = 96/159 (60%), Gaps = 1/159 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+LI A A + VIG +N MPW+LP D +FK+NTL VIMGR T+E+IG+ LP R+NI+ Sbjct: 6 ITLIVAAAENNVIGKDNQMPWHLPNDFKYFKKNTLEHSVIMGRKTFEAIGKALPDRRNIV 65 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S V S+ EAI C D E+ VIGG +YEQ LP A K+ LT + +E Sbjct: 66 ISRNQDFHHPDVDTANSLQEAILYCRDEREVFVIGGANIYEQTLPFAHKVLLTRVHTTIE 125 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP P++W E H AD +++ Y F++ R+ Sbjct: 126 GDAVFPVLNPEEWMLESEEKHFADDKHAFDYTFQVFNRK 164 >UniRef50_Q31I54 Dihydrofolate reductase n=32 Tax=Bacteria RepID=Q31I54_THICR Length = 175 Score = 204 bits (519), Expect = 1e-51, Method: Composition-based stats. Identities = 73/160 (45%), Positives = 113/160 (70%), Gaps = 2/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+IAA+ R+IG +N MPW+LP DL +FK NT+NKPVIMGR T+ESIG +PLP R+N+ Sbjct: 14 ISMIAAMDKHRIIGADNDMPWHLPDDLKFFKANTVNKPVIMGRKTFESIGSKPLPNRRNL 73 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ + + S +EA+ +C EI+++GGG++Y Q +P A KLY+T +DAEV Sbjct: 74 VITRNDAYEANGAEVFHSAEEALKSCKSEVEIIIMGGGQLYAQMMPFANKLYVTLVDAEV 133 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP++ D+W+ + E+HD D ++++++ F L R+ Sbjct: 134 AGDTTFPEWLTDEWQEISKEWHDKDERHAYAFEFVTLIRK 173 >UniRef50_Q2SXY8 Dihydrofolate reductase n=18 Tax=Proteobacteria RepID=Q2SXY8_BURTA Length = 219 Score = 203 bits (517), Expect = 2e-51, Method: Composition-based stats. Identities = 67/161 (41%), Positives = 95/161 (59%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A A + VIG +N +PW LP DLA+FKR T+ P++MGR T ESIGRPLPGR+NI+ Sbjct: 56 LTLIVARARNGVIGRDNRLPWKLPEDLAFFKRTTMGAPIVMGRKTHESIGRPLPGRRNIV 115 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D S+ +A+A E +IGG ++Y + L A KL +T ID + Sbjct: 116 VTRDAARRFDGCDTATSLGDALALAERDGAAEAFLIGGAQLYAEGLRHADKLIVTEIDQD 175 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP +P WE+V + H A N +Y F + R+ Sbjct: 176 FEGDASFPAPDPAQWEAVSRDAHRAAPPNDFAYAFVVYRRK 216 >UniRef50_Q2Y7L3 Dihydrofolate reductase n=7 Tax=Betaproteobacteria RepID=Q2Y7L3_NITMU Length = 183 Score = 203 bits (516), Expect = 2e-51, Method: Composition-based stats. Identities = 70/169 (41%), Positives = 102/169 (60%), Gaps = 14/169 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A+A +R IG +NA+PW+LP DL FK T+ P+IMGR T+ESIGR LPGR +II Sbjct: 5 LSVLVAMARNRAIGHKNAIPWHLPHDLKHFKELTMGHPMIMGRKTYESIGRLLPGRTSII 64 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDV-----------PEIMVIGGGRVYEQFLPKAQK 109 ++ QP + V S+ EA++AC + E VIGG +++Q LP + Sbjct: 65 ITRQPDYEVPGALVVSSIGEALSACKQIRSGEEGHPDQGNECFVIGGADIFQQMLPLCDR 124 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LY+T I + EGDT+FP+++ +DW V E H D+ Y F L+R Sbjct: 125 LYMTEIHRDFEGDTYFPEFDRNDWWEVSREEHVDDS--GLEYHFVTLDR 171 >UniRef50_C6X2F4 Dihydrofolate reductase n=20 Tax=Bacteroidetes RepID=C6X2F4_FLAB3 Length = 167 Score = 202 bits (514), Expect = 3e-51, Method: Composition-based stats. Identities = 61/161 (37%), Positives = 93/161 (57%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI+++ A+ + IG +N + W+LP DL FK T P+IMGR T+ESIGRPLP R NI Sbjct: 1 MITIVVAMGLKNEIGADNQLLWHLPQDLKHFKEITTGHPIIMGRKTYESIGRPLPNRTNI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++S + + V V S+ EA+ + E + VIGGG +YEQ + A KL +T + AE Sbjct: 61 VVSRKKDWFAEGVLIVGSLKEALKFAKKIDENVFVIGGGNIYEQTIDLADKLEVTLVKAE 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D FP + WE D D ++++ +CF+ ++ Sbjct: 121 INADIFFPKIDLKIWEKTSETCIDKDEKHAYDFCFQTFVKK 161 >UniRef50_UPI0001787F40 Dihydrofolate reductase n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001787F40 Length = 162 Score = 202 bits (514), Expect = 3e-51, Method: Composition-based stats. Identities = 71/163 (43%), Positives = 103/163 (63%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MIS+I A+ D+VIG+ MPW LP D+A+FK TL+K ++MGR TW+S G +PLP RKN Sbjct: 1 MISMIWAMGKDQVIGLNGTMPWRLPRDMAFFKEKTLHKTILMGRKTWDSFGGKPLPHRKN 60 Query: 60 IILSSQPG---TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ T+D+ + ++ A+ + E+MVIGG ++YE LPKA +LY T ID Sbjct: 61 IVLTRDESFTLTEDQGIVIHDIENALPYSKN-EELMVIGGSQIYELMLPKADRLYCTFID 119 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGDT+FP+ D+W+ V D +N ++Y F ER+ Sbjct: 120 ESFEGDTYFPEVNWDEWKIVEEVPGITDEKNPYAYRFVTFERK 162 >UniRef50_Q0VM07 Dihydrofolate reductase n=5 Tax=Gammaproteobacteria RepID=Q0VM07_ALCBS Length = 171 Score = 201 bits (512), Expect = 6e-51, Method: Composition-based stats. Identities = 69/165 (41%), Positives = 100/165 (60%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A A + VIG N +PW LP DL +FK+ T KPVIMGR TWES+ PLPGR NI+ Sbjct: 7 LSMMVAKATNNVIGRNNKLPWYLPNDLKYFKQVTFGKPVIMGRKTWESLKGPLPGRTNIV 66 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ QP + V +VD+AI + E +++GG +Y L + Q+LYLT Sbjct: 67 ITRQPAYQAEGAKVVATVDDAITMAENVAFIEGQEEAVIMGGAEIYALALAQTQRLYLTE 126 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AEV+GDT FP+Y+ +WE + E A+ N + Y F + ER+ Sbjct: 127 VHAEVDGDTFFPEYDKGEWEEIAREDFPAEGPNPYDYSFVVYERK 171 >UniRef50_A2SN57 Dihydrofolate reductase n=34 Tax=Burkholderiales RepID=A2SN57_METPP Length = 259 Score = 201 bits (511), Expect = 7e-51, Method: Composition-based stats. Identities = 68/163 (41%), Positives = 93/163 (57%), Gaps = 5/163 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 +++IAA A + VIG N +PW LP DLA F+ T PVIMGR TWES+ RPLPGR+ Sbjct: 3 LAIIAACARNGVIGRNNDLPWRLPEDLAHFRSTTGGWPVIMGRLTWESLPARFRPLPGRR 62 Query: 59 NIILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 NII+S G V V S++ A+ VIGG R+YE LP A +L+LT ID Sbjct: 63 NIIVSRGGVRGVPKGVDVVASLEAALELVQAERRAFVIGGARLYEAALPLADELFLTEID 122 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + EGD +FP+++ + A+A N+ +Y F R+ Sbjct: 123 EDFEGDVYFPEFDRSAFVEHHRMRRQAEAPNTFTYSFAHYRRK 165 >UniRef50_Q1QUE0 Dihydrofolate reductase n=12 Tax=Bacteria RepID=Q1QUE0_CHRSD Length = 195 Score = 201 bits (511), Expect = 8e-51, Method: Composition-based stats. Identities = 65/167 (38%), Positives = 96/167 (57%), Gaps = 10/167 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+L+AA++ +RVIG++N +PW+LP DL +FK T++KP++MGR T+ESIGRPLPGR NI+ Sbjct: 19 IALVAAMSRNRVIGVDNKLPWHLPEDLKFFKAVTMSKPLVMGRKTFESIGRPLPGRLNIV 78 Query: 62 LSSQPGT---DDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYL 112 ++ G D + + A+ +I VIGGG ++ + LP A +LYL Sbjct: 79 VTRDRGYAQDHDGIRVCHDLASALDMADGQAIIDGVEDICVIGGGEIFAEALPCATRLYL 138 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T +D EVEGD FP ++ +W+ Y F RR Sbjct: 139 TEVDIEVEGDAWFPAFDAREWQETQRVPGQGGEGKP-EYAFVHYTRR 184 >UniRef50_C9RIZ1 Dihydrofolate reductase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RIZ1_FIBSS Length = 163 Score = 200 bits (510), Expect = 1e-50, Method: Composition-based stats. Identities = 60/162 (37%), Positives = 87/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS I A++ + VIG + +PW+L ADL FK T +I+GR ++ IGRPLP R N Sbjct: 2 LISAIVAVSENNVIGRDGHLPWHLSADLKRFKAITTGHAIILGRKNYDDIGRPLPNRTNY 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+ S+ EAI A E +IGG VY + +P +KLYLT + + Sbjct: 62 VLTRNKDFQAPGCIVCSSLGEAIEAARAAGETECFIIGGAAVYREAMPLVEKLYLTRVLS 121 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 VEGD FP++ D ++ +E AD +N FEI R+ Sbjct: 122 HVEGDVFFPEWN-DKFQKESAESFPADEKNDFPTTFEIWVRK 162 >UniRef50_A1AXR7 Dihydrofolate reductase n=6 Tax=Proteobacteria RepID=A1AXR7_RUTMC Length = 163 Score = 200 bits (509), Expect = 1e-50, Method: Composition-based stats. Identities = 62/158 (39%), Positives = 102/158 (64%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ +++IG NA+PW LPADLA+FK+ T+ K V+MGR T++SIGRPL R+NII Sbjct: 3 LSIIVAMDDNQLIGKNNALPWYLPADLAYFKKTTIGKAVLMGRKTYDSIGRPLSNRRNII 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S++ A+ E+M++GG YEQ + K ++Y+T ++ + + Sbjct: 63 VSRNTKLKVDGCEVVGSINVALNLVNGANELMIMGGVSFYEQMIDKVDRIYITEVNGKFD 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP+++ + + E H D +N H++ F IL++ Sbjct: 123 GDTYFPEFDRTKFSELSRESHQPDEKNLHAHNFVILQK 160 >UniRef50_Q1CZU3 Dihydrofolate reductase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1CZU3_MYXXD Length = 159 Score = 200 bits (509), Expect = 2e-50, Method: Composition-based stats. Identities = 66/160 (41%), Positives = 89/160 (55%), Gaps = 6/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S I A+A +RVIG N +PW LPADLA FKR T+ ++MGR T+ESIGRPLPGR I+ Sbjct: 3 LSAIVAMAANRVIGAGNQLPWRLPADLARFKRITMGHTLVMGRKTYESIGRPLPGRTFIV 62 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q V SVDEA++ E+ + GG +Y Q + + Q++YLTHI Sbjct: 63 VTRQRDFAPPGVQVAHSVDEALSLAKASGDSEVFIAGGADLYAQTMDRVQRIYLTHIARN 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FPD + W V + H + F ER Sbjct: 123 FPGDTWFPDVDLSGWTCVEEQAHPDAE---PPHTFLTYER 159 >UniRef50_Q3K556 Dihydrofolate reductase n=8 Tax=Bacteria RepID=Q3K556_PSEPF Length = 170 Score = 199 bits (508), Expect = 2e-50, Method: Composition-based stats. Identities = 69/164 (42%), Positives = 104/164 (63%), Gaps = 8/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLIAAL +RVIG++N+MPW+LP D +FK TL KP+IMGR TW+S+GRPLPGR NI+ Sbjct: 7 LSLIAALGENRVIGVDNSMPWHLPGDFKYFKATTLGKPIIMGRKTWDSLGRPLPGRLNIV 66 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S Q G + S++ A+ + E+M+IGG ++Y Q L +A +LYLT Sbjct: 67 VSRQAGLVLEGAEVYPSLEAAVVRAEEWAKDQGVDELMLIGGAQLYAQGLAQADRLYLTR 126 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGD FP+++ + W+ V + + A + +Y FE+ E+ Sbjct: 127 VALSPEGDAWFPEFDLNQWKLVSNVPNPA-EGDKPAYNFEVWEK 169 >UniRef50_A5EUV9 Dihydrofolate reductase n=1 Tax=Dichelobacter nodosus VCS1703A RepID=A5EUV9_DICNV Length = 164 Score = 199 bits (508), Expect = 2e-50, Method: Composition-based stats. Identities = 63/159 (39%), Positives = 92/159 (57%), Gaps = 1/159 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LIAA ++RVIG + MPW+LP DL FK+ T +IMGR T++S+ +PLP RKNI+ Sbjct: 6 IHLIAAQTLNRVIGKDGGMPWHLPRDLQHFKQRTSGHTIIMGRKTFQSLKKPLPNRKNIV 65 Query: 62 LSSQPG-TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S V ++ EA+A C + ++ +IGGG +Y + +A L +T I E+ Sbjct: 66 ISHSGQPLHADVAVFPAISEALAFCCNDEKVFIIGGGSLYAATIDEADFLTITWIHTELL 125 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP P DW+ ADA+N+ + F +RR Sbjct: 126 GDTFFPPIRPQDWQETHRSHFAADAKNAFALDFVDYQRR 164 >UniRef50_Q67JQ2 Dihydrofolate reductase n=1 Tax=Symbiobacterium thermophilum RepID=Q67JQ2_SYMTH Length = 165 Score = 199 bits (508), Expect = 2e-50, Method: Composition-based stats. Identities = 66/153 (43%), Positives = 87/153 (56%), Gaps = 4/153 (2%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 + +R IG E +PW LPA++ F+R T+ K V+MGR T+ESIG PL GR NI+L+ PG Sbjct: 1 MGRNRAIGREGRLPWRLPAEMRHFRRTTMGKAVVMGRRTYESIGGPLKGRTNIVLTRDPG 60 Query: 68 T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 SV E + D + VIGG VY QFLP A ++ LT ID + EGD FP Sbjct: 61 FRAPGCEVRHSVAELLQ---DRRPLYVIGGAEVYRQFLPHADEMILTRIDHDFEGDAFFP 117 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D+WE V S H D +N + + E RR Sbjct: 118 AWSEDEWELVGSTPHPRDEENPYDFVVEHYRRR 150 >UniRef50_C7PKU6 Dihydrofolate reductase n=1 Tax=Chitinophaga pinensis DSM 2588 RepID=C7PKU6_CHIPD Length = 164 Score = 199 bits (507), Expect = 3e-50, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A + + VIG+ N +PW+LP D+ +FK T+ KP++MGR ++E +GR LPGR NI+ Sbjct: 3 LSIIVAASENNVIGINNHLPWHLPVDMKYFKDTTMGKPIVMGRKSFEELGRVLPGRPNIM 62 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q + + V S++ I EI V GGG +++ L ++YLT + A Sbjct: 63 ITRQKDYTAEGLHIVPSLEAGIEKAKTFGTEEIFVTGGGEIFKMALSIVDRVYLTRVHAT 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V+GDT+FP+++P W+ V +E H+ D +++H+ F++ ER Sbjct: 123 VQGDTYFPEFDPRGWKLVKNERHEKDEKHAHALTFQVWER 162 >UniRef50_C0YTZ2 Possible dihydrofolate reductase type I involved in trimethoprim resistance n=1 Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YTZ2_9FLAO Length = 165 Score = 198 bits (505), Expect = 4e-50, Method: Composition-based stats. Identities = 61/160 (38%), Positives = 92/160 (57%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M +++ A+ IG EN + W+LP DL FK T PVIMGR T+ESIG+ LP R NI Sbjct: 1 MTTIVVAMGEKNEIGFENQLLWHLPKDLKHFKEITSGHPVIMGRKTYESIGKALPNRTNI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++S + ++ + V S+ EA+ E+ VIGGG +YEQ + +L +T + A+ Sbjct: 61 VVSRKKDWFEEGILIVGSIKEALKFAKKIDEEVFVIGGGNIYEQTMDVVDRLEVTLVKAD 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +E DT FP +P W+ H+ D +N + +CF+ ER Sbjct: 121 LEADTFFPKIDPKIWKMTNEICHEKDEKNGYDFCFQTFER 160 >UniRef50_C7RLL7 Dihydrofolate reductase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RLL7_9PROT Length = 169 Score = 198 bits (504), Expect = 6e-50, Method: Composition-based stats. Identities = 62/169 (36%), Positives = 88/169 (52%), Gaps = 10/169 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MISLIAA+A + IG + W LP D+ +F+ T K VIMGR TWES+ RPLP R Sbjct: 1 MISLIAAVARNGAIGRNQQLLWRLPEDMRYFRETTSGKTVIMGRKTWESLPPAYRPLPNR 60 Query: 58 KNIILSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS P S+++A+ G E+ +IGG +Y Q +P A +LY+T + Sbjct: 61 RNIVLSRNPAYLPRGGDLACSIEDALRLAGGAAEVFIIGGEELYRQTMPLATRLYITEVA 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSE------FHDADAQNSHSYCFEILERR 159 E GD FPD +W + A + ++ F + ERR Sbjct: 121 EESPGDAFFPDVASGEWREISRRVGRSRAAGSALRDQAPAFDFVVYERR 169 >UniRef50_Q15PF1 Dihydrofolate reductase n=18 Tax=Gammaproteobacteria RepID=Q15PF1_PSEA6 Length = 171 Score = 198 bits (503), Expect = 7e-50, Method: Composition-based stats. Identities = 81/168 (48%), Positives = 107/168 (63%), Gaps = 11/168 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+++AA+A RVIG+ N MPW++PADL FKR TL KP++MGR T+ESIGR LPGR NI+ Sbjct: 4 IAMVAAMANQRVIGLNNQMPWHMPADLKHFKRITLGKPIVMGRKTYESIGRALPGRLNIV 63 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAAC----------GDVPEIMVIGGGRVYEQFLPKAQKL 110 ++S + V S ++AIA E+MVIGGG VY+ FLP A +L Sbjct: 64 ITSDQNYQLADASIVHSCEQAIAVATSHMQNDGMPEHDQEVMVIGGGTVYQHFLPHANRL 123 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 YLT ID + GDT+FP+Y W+ + SE +D D +N HSY F L R Sbjct: 124 YLTFIDLDTPGDTYFPNYSDGAWQEIESESNDPDEKNPHSYRFVTLAR 171 >UniRef50_C9BJS9 Dihydrofolate reductase n=13 Tax=Enterococcus RepID=C9BJS9_ENTFC Length = 175 Score = 197 bits (502), Expect = 9e-50, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 89/161 (55%), Gaps = 3/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M++ I A + +IG E+ +PW LP DL +FK+ T ++MGR T+E +G RPLP R+ Sbjct: 1 MLAAIWAQDENGLIGKEDRLPWRLPNDLKFFKQMTEANTLVMGRKTFEGMGSRPLPNRQT 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVI-GGGRVYEQFLPKAQKLYLTHIDA 117 I+L+ + V + SV++ +A + I I GG VY++FLP LY T I Sbjct: 61 IVLTRDSSYKAEGVHVMHSVEDVLALEKETDGIFFIAGGSAVYQEFLPFCTILYRTVIHH 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +GD +FP + DW + + + D +N + + FE +R Sbjct: 121 VFDGDAYFPPVDWSDWSLINTSQGEMDEKNRYPHQFETYQR 161 >UniRef50_Q5WDS2 Dihydrofolate reductase n=3 Tax=Bacillus RepID=Q5WDS2_BACSK Length = 162 Score = 197 bits (502), Expect = 9e-50, Method: Composition-based stats. Identities = 51/160 (31%), Positives = 80/160 (50%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG +N +PW+LPADL FKR T + ++MGR T++S+G PLP RKN+ Sbjct: 1 MIVFVYARDAHYGIGKDNGLPWHLPADLRHFKRTTTGQTIVMGRKTFDSMGGPLPNRKNV 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ + + S+D+ + I VIGG ++ K +T ID + Sbjct: 61 VLTRSRSFQAEGAEVIHSLDDVLQLSKQ-EAIYVIGGAEIFALLWDICDKHIVTVIDEKF 119 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E DT P +WE V + D +N + + + R+ Sbjct: 120 EADTFVPPLSEQEWELVETVPGPIDEKNRYPHEYRTYVRK 159 >UniRef50_Q5R038 Dihydrofolate reductase n=3 Tax=Alteromonadales RepID=Q5R038_IDILO Length = 166 Score = 197 bits (502), Expect = 9e-50, Method: Composition-based stats. Identities = 85/162 (52%), Positives = 117/162 (72%), Gaps = 5/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISL+ A+A +RVIG +N MPW+LP +L +FK+ TL KP++MGR T+ESIGRPLPGRKNI+ Sbjct: 3 ISLVVAMADNRVIGKDNKMPWHLPDELQYFKKITLGKPIVMGRRTFESIGRPLPGRKNIV 62 Query: 62 LSSQPGTDDR----VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 LS + + V WV V +AIAA G V E+M+IGGG++YE+FLP A +LY+T I+ Sbjct: 63 LSRRTDRSENQDSQVVWVSGVQQAIAAAGPVEELMIIGGGKIYEKFLPLADRLYVTKIEL 122 Query: 118 EVEGDTHFPDY-EPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGDT+FPDY + DW+ + + AD +NSH++ I +R Sbjct: 123 NVEGDTYFPDYHQVADWQEIERQNFAADERNSHNFSTLIFDR 164 >UniRef50_C1XJD1 Dihydrofolate reductase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XJD1_MEIRU Length = 171 Score = 197 bits (501), Expect = 1e-49, Method: Composition-based stats. Identities = 62/159 (38%), Positives = 94/159 (59%), Gaps = 5/159 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ + A+ +R IG +PW+LP DL F+ TL K V+MGR T+ESIGRPLP R+N++ Sbjct: 5 IAFVVAMDQNRAIGRAGTLPWHLPDDLKRFRALTLGKTVLMGRKTFESIGRPLPKRRNVV 64 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 L+ P + V V ++++A+ E+MVIGGG +Y FLP L+LT ++ V Sbjct: 65 LTRDPAFAAEGVEVVHTLEDALKL---DDELMVIGGGEIYTLFLPLVTHLHLTLVETVVP 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + D FP + P W + E H AD ++ ++ + LER Sbjct: 122 DADAFFPPWNPTGWRETYREHHPADERHPWAFTYLDLER 160 >UniRef50_Q47IJ5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=Q47IJ5_DECAR Length = 163 Score = 197 bits (501), Expect = 1e-49, Method: Composition-based stats. Identities = 57/162 (35%), Positives = 86/162 (53%), Gaps = 6/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LIAA+A +RVIG +N + WNLP D+A FK T + V+MGR TWES+ RPLPGR+ Sbjct: 4 IILIAAVAKNRVIGKDNTLIWNLPEDMAHFKALTAGQTVVMGRKTWESLPPRFRPLPGRR 63 Query: 59 NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N+++S Q S++ A+ + +IGG ++Y+Q + A +L +T +D Sbjct: 64 NVVISRQADYAAPGAEVANSLENALQLASTAESVFIIGGEQIYKQAMAVADRLEITDVDL 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E GD FP+ DW + + + F R+ Sbjct: 124 EPAGDAWFPEIAATDWSVTQKNTPPSQS--GTGFSFVTYRRK 163 >UniRef50_A5GBA2 Dihydrofolate reductase n=2 Tax=Geobacter RepID=A5GBA2_GEOUR Length = 163 Score = 197 bits (501), Expect = 1e-49, Method: Composition-based stats. Identities = 69/160 (43%), Positives = 98/160 (61%), Gaps = 6/160 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+A +RVIG NA+PW++PAD F+ TL PVIMGR T+ES+ PLPGRKNI Sbjct: 2 VISLIAAMAENRVIGRNNAIPWDIPADRKRFRALTLGHPVIMGRKTFESLAGPLPGRKNI 61 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ Q + + A+A G+ EI + GGG +Y Q LP A ++YLT I + Sbjct: 62 IITRQMDYRAEGCFIAHDLASALAMAGETDEIFICGGGEIYRQALPIADRIYLTIIHSRF 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT FP+ P+ + V E +N+ Y F + ++R Sbjct: 122 DGDTRFPEI-PERFVEVGRETV----ENAIPYSFVLYDKR 156 >UniRef50_A7HVX5 Dihydrofolate reductase n=13 Tax=Proteobacteria RepID=A7HVX5_PARL1 Length = 169 Score = 197 bits (501), Expect = 1e-49, Method: Composition-based stats. Identities = 67/165 (40%), Positives = 97/165 (58%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +S + A+A + VIG +N++PW L D+A+FKR T+ KPVIMGR TWES+ R PLPGR NI Sbjct: 3 VSYVVAIADNGVIGRDNSLPWRLSGDMAFFKRITMGKPVIMGRKTWESLPRKPLPGRPNI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAI------AACGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +++ + + S EA+ A+ E+MVIGG ++Y + A +LY+T Sbjct: 63 VVTRDAQYEAEGAEIAASAVEALRRGRELASASGADEVMVIGGAQLYAEMFDDATRLYIT 122 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A EGD FP ++ W V E H A ++S Y F +LER Sbjct: 123 EVHAAPEGDVSFPAFDAAHWREVSRERHKAGEKDSADYSFVVLER 167 >UniRef50_A1VQZ7 Dihydrofolate reductase n=9 Tax=Bacteria RepID=A1VQZ7_POLNA Length = 166 Score = 196 bits (500), Expect = 1e-49, Method: Composition-based stats. Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 7/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I+LI A A + VIG NAMPW+LP DLA FKR T PVIMGR TW+S+ RPLPGR Sbjct: 6 INLIYARAANGVIGRNNAMPWHLPEDLAHFKRLTQGWPVIMGRKTWDSLPPRFRPLPGRT 65 Query: 59 NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N++++ QP S+ +A+A C E+ VIGG ++Y P A ++ +T I Sbjct: 66 NLVITRQPDWQAPGALPAASLADALAQCSQSEEVWVIGGAQIYAHAEPLADRIEVTEIAQ 125 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GD P ++W+ E H + + + F E+ Sbjct: 126 DFDGDAFAPPLG-EEWQETAREAHVSS--HGLPFSFVTFEK 163 >UniRef50_D0J2N2 Dihydrofolate reductase region n=3 Tax=Bacteria RepID=D0J2N2_COMTE Length = 167 Score = 196 bits (500), Expect = 1e-49, Method: Composition-based stats. Identities = 66/167 (39%), Positives = 91/167 (54%), Gaps = 12/167 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LI A A + VIG +N MPW+LP D+A FK T VIMGR TW+S+ RPLPGR Sbjct: 3 IQLIYARAANGVIGKDNTMPWHLPEDMAHFKELTRGCAVIMGRKTWDSLPPRFRPLPGRS 62 Query: 59 NIILSSQPGTD-----DRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYL 112 NI+++ Q D+V S+ EA+ + ++ VIGG ++Y Q LP A + + Sbjct: 63 NIVVTRQADWQAEPASDQVLRAASLSEALELGRNLSQDVWVIGGAQIYAQALPLADAVEV 122 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I + EGD P+ + W++V H + N YCF ERR Sbjct: 123 TEIGRDFEGDAFAPELG-EQWQAVSRSEH--VSANGLPYCFVRFERR 166 >UniRef50_UPI0000E87D66 dihydrofolate reductase n=1 Tax=Methylophilales bacterium HTCC2181 RepID=UPI0000E87D66 Length = 161 Score = 196 bits (500), Expect = 2e-49, Method: Composition-based stats. Identities = 61/159 (38%), Positives = 96/159 (60%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A++ + VIG+ N +PW++P DL FK T+ P++MGR T++SIGRPLPGRKNI+ Sbjct: 4 ISIIVAMSNNNVIGINNTLPWHIPQDLKRFKSLTMGNPIVMGRKTFDSIGRPLPGRKNIV 63 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + + V V S++ +A D + VIGG ++Y+ FL A LY+T +D++V Sbjct: 64 ITRNEDSIIEGVEIVNSINSLLALIKDEEHVFVIGGEQIYKIFLDHATHLYVTEVDSDVA 123 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD HFP W+ V E +++ + F R+ Sbjct: 124 GDAHFPKLSTSQWKEVGREK--LVSKDDLHFSFVDYIRQ 160 >UniRef50_A2U3M8 Dihydrofolate reductase n=2 Tax=Polaribacter RepID=A2U3M8_9FLAO Length = 164 Score = 196 bits (499), Expect = 2e-49, Method: Composition-based stats. Identities = 60/161 (37%), Positives = 90/161 (55%), Gaps = 3/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI++IAA+A + +G N + W+LPADL FK+ T ++MGR+T+ESIGRPLP R I Sbjct: 1 MITIIAAIAKNNALGKNNDLIWHLPADLKRFKKVTTGHHILMGRNTFESIGRPLPNRITI 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 I++ + SV++A+ D +I +IGG +VYE + A L +T + Sbjct: 61 IITKNEEYVQEGCLIANSVEQALEMAHDDDQIFIIGGAQVYEYAMKHDFADALDITLVHH 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E E D +FP+ +P W V E AD +N Y F ++ Sbjct: 121 EFEADVYFPEIDPTVWRRVEREDFIADEKNKFDYSFIRYKK 161 >UniRef50_C6CYL9 Dihydrofolate reductase n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CYL9_PAESJ Length = 163 Score = 196 bits (499), Expect = 2e-49, Method: Composition-based stats. Identities = 69/160 (43%), Positives = 102/160 (63%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I++IAA+ R IG+ N +PW LPA++A+F R+T K V+MGR T+ES+ +PL R N++ Sbjct: 3 ITMIAAMDRGRTIGIGNKLPWRLPAEMAYFTRHTTGKAVVMGRKTFESLPKPLKDRTNVV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ QP + V SV EAI G+ E+MVIGG +Y QFLP A K+ LT +D +E Sbjct: 63 ITRQPEYAKEGCEVVHSVQEAIDRYGEG-ELMVIGGADIYAQFLPFADKIRLTEVDTNIE 121 Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP + +WE V +E ++D +N+ S+ F+ RR Sbjct: 122 GGDAFFPTFNEGEWERVDAEKVESDERNAFSFTFQTFARR 161 >UniRef50_Q04F50 Dihydrofolate reductase n=2 Tax=Oenococcus oeni RepID=Q04F50_OENOB Length = 170 Score = 196 bits (498), Expect = 3e-49, Method: Composition-based stats. Identities = 64/164 (39%), Positives = 94/164 (57%), Gaps = 5/164 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+ I A + + VIG N +PW+LP DL +F++ T NK V+MGR T+ES G + LP R N Sbjct: 1 MITSIWAQSKNNVIGRNNHLPWSLPDDLKFFRQETKNKAVVMGRKTYESFGSKALPKRLN 60 Query: 60 IILSSQPGT---DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHI 115 IIL+S D V V S EA+ + + VIGG VYE F+ A +L +T + Sbjct: 61 IILTSNMDFKSNDPEVKIVHSPIEAVNTAKEQHLPLYVIGGASVYESFMNMADRLLITLV 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 DA ++GDT P++ + V H D ++++S+ F ER+ Sbjct: 121 DANIKGDTFAPNFSEKSFSLVSQCHHAQDKKHAYSFDFLTYERK 164 >UniRef50_Q5X875 Dihydrofolate reductase FolA n=6 Tax=Legionella RepID=Q5X875_LEGPA Length = 163 Score = 195 bits (496), Expect = 4e-49, Method: Composition-based stats. Identities = 64/158 (40%), Positives = 89/158 (56%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+ +G+ N + LPADL FK T+ KP+IMGR T+ESIG+PLPGR NI Sbjct: 3 LISLIAAIDETGGLGINNQLLCYLPADLQHFKSITMGKPIIMGRKTYESIGKPLPGRLNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++S + V V S+ +AI D E+M+IGG ++Y Q + A +LY+T I + Sbjct: 63 VISQSIQSIPGVVVVDSLGQAIKETADASEVMIIGGAKIYSQAISIANRLYITRIHHQFM 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 D FP W E+ D +N + F I ER Sbjct: 123 ADVFFPKINELVWSCRSKEYRQHDNKNQYDMTFCIYER 160 >UniRef50_A6UB22 Dihydrofolate reductase n=18 Tax=Alphaproteobacteria RepID=A6UB22_SINMW Length = 187 Score = 194 bits (495), Expect = 5e-49, Method: Composition-based stats. Identities = 67/165 (40%), Positives = 96/165 (58%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I ++ A+A++ VIG E +PW LP DL FK T+ KPVIMGR TW +IGRPLPGR NI+ Sbjct: 14 IVIVVAVALNGVIGREGDLPWRLPTDLKRFKAQTIGKPVIMGRKTWAAIGRPLPGRPNIV 73 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ + S++ A+A + EI VIGGG +Y Q + A L++T Sbjct: 74 VTRNRAFEAPGAEVAPSLEAALAVARERAAAIGADEICVIGGGEIYRQSIGMADVLHVTE 133 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AEV+GDT FP+ +P +E V E + ++SH+ F RR Sbjct: 134 VQAEVDGDTRFPEIDPAVFEKVLEEDLQSGEKDSHAMHFVTWRRR 178 >UniRef50_D1BNV5 Dihydrofolate reductase region n=4 Tax=Veillonellaceae RepID=D1BNV5_VEIPT Length = 164 Score = 194 bits (495), Expect = 6e-49, Method: Composition-based stats. Identities = 54/161 (33%), Positives = 86/161 (53%), Gaps = 2/161 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M++LI A+A +RVIG +N + W+LP DL +FK T +IMGR T+ES+ LP R++ Sbjct: 1 MLALIVAVAHNRVIGKDNTLIWHLPNDLKFFKEKTTGHVIIMGRKTFESLPFLLPNREHW 60 Query: 61 ILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +++ + V + + A A + VIGG +VYE FLP +Y+T +D E Sbjct: 61 VITRDKGFDAPEGVKIFHNPEAAAEAARALDAAYVIGGAQVYEAFLPYVDTMYITEVDHE 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GD FP++ D + D +N + + F R+ Sbjct: 121 FDGDAFFPEFSEDAFTIESVVDGIVDEKNQYPHRFVTYRRK 161 >UniRef50_A4IUE2 Dihydrofolate reductase n=1 Tax=Yersinia ruckeri RepID=A4IUE2_YERRU Length = 191 Score = 194 bits (495), Expect = 6e-49, Method: Composition-based stats. Identities = 68/162 (41%), Positives = 101/162 (62%), Gaps = 5/162 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLI A+A + IG +NA+PW+LP DL + K++T+ KP++MGR T++SIGRPLPGR N+ Sbjct: 27 IISLILAMADNGTIGDKNALPWHLPNDLQFLKKSTMGKPIVMGRKTYQSIGRPLPGRTNV 86 Query: 61 ILSSQPGTD--DRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 ++S + + AIAA +V EIM++GG ++Y LP +LYLTH+ Sbjct: 87 VISRSLEKEALPGCLIYSDLSVAIAALKKEPEVEEIMIMGGAQIYRAALPMMDRLYLTHV 146 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 A +EGDT P ++ +F E H D +N + Y FEI + Sbjct: 147 HANIEGDTQMPPFDFSHATLIFEEKHFKDEKNRYDYTFEIWD 188 >UniRef50_A5CVJ7 Dihydrofolate reductase n=1 Tax=Candidatus Vesicomyosocius okutanii HA RepID=A5CVJ7_VESOH Length = 163 Score = 194 bits (493), Expect = 9e-49, Method: Composition-based stats. Identities = 60/158 (37%), Positives = 100/158 (63%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A+ + +IG +N++PW LPADLA+FK+ T+ K ++MGR T +SIGR LP R+NII Sbjct: 3 LSIIVAMDDNYLIGKDNSLPWYLPADLAYFKKITIGKTILMGRKTHDSIGRSLPNRRNII 62 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S D V S+D A++ + E+M++GG Y+Q + K +LY+T + + Sbjct: 63 VSKNTKFKADNCEVVSSIDVALSLANNDNELMIVGGSSFYDQIIDKVDRLYITEVKGMFD 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD +FP+++ + + E H D +N ++Y F +L+R Sbjct: 123 GDAYFPEFDRTKFIELSRESHKPDEKNFYTYNFIVLQR 160 >UniRef50_Q21NW4 Dihydrofolate reductase n=3 Tax=Bacteria RepID=Q21NW4_SACD2 Length = 171 Score = 194 bits (493), Expect = 1e-48, Method: Composition-based stats. Identities = 61/169 (36%), Positives = 98/169 (57%), Gaps = 11/169 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + ++ A A + VIG+ N +PW + ADL FK+ T+ P+IMGR T++SIG+PLPGR I+ Sbjct: 3 LVIVVAAAQNGVIGINNTLPWRISADLQHFKQVTIGHPIIMGRKTYDSIGKPLPGRTTIV 62 Query: 62 LSSQPG-----TDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQFLPKAQKL 110 ++ Q +D+V S++ A+ + E M++GG ++Y Q L + K+ Sbjct: 63 VTRQADWQAEGYEDQVKVAYSLEGAMELAEQIAAQMGVAEAMLVGGAQLYRQALERVSKV 122 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +LT + AE+EGD FP+ + + W V + AD +N + Y F L RR Sbjct: 123 HLTRVHAEIEGDAWFPELDGNIWAEVQCVRYKADEKNEYDYSFVELHRR 171 >UniRef50_C5CTW3 Dihydrofolate reductase n=1 Tax=Variovorax paradoxus S110 RepID=C5CTW3_VARPS Length = 177 Score = 193 bits (491), Expect = 2e-48, Method: Composition-based stats. Identities = 62/163 (38%), Positives = 93/163 (57%), Gaps = 7/163 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I LI A A + VIG + +PW+LP D+ FK+ T PV+MGR TW+S+ RPLPGR+ Sbjct: 10 IHLIFARAANGVIGAKGTIPWHLPEDMVHFKQQTAGAPVVMGRKTWDSLPPRFRPLPGRR 69 Query: 59 NIILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHI 115 NI+++ Q + V S+ EA+A C + P++ +IGG ++Y + P AQ++ +T + Sbjct: 70 NIVVTRQDDWKAEGAWRVGSLQEALALCEESQVPDVWIIGGAQIYAEAEPLAQQVVVTEL 129 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGD H P+ P W E H A+ +Y F ER Sbjct: 130 AHDYEGDAHAPELSPSAWRETKREAH-VSAKEGLNYSFVTYER 171 >UniRef50_UPI0001698640 dihydrofolate reductase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001698640 Length = 158 Score = 193 bits (491), Expect = 2e-48, Method: Composition-based stats. Identities = 71/149 (47%), Positives = 97/149 (65%), Gaps = 1/149 (0%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 +A +RVIG N MPW+LPADL FK T+ KP++MGR TWES+ LP R +I+++ P Sbjct: 1 MARNRVIGRHNRMPWHLPADLRHFKALTIGKPIVMGRKTWESLPGLLPDRPHIVVTHNPS 60 Query: 68 T-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 + T V S+DEAIAA G+V EIMV+GGG Y + LP+ ++YLT +DAE EGDT FP Sbjct: 61 YYAEGCTLVHSIDEAIAAAGEVEEIMVVGGGAFYAEILPRVGRIYLTLVDAEFEGDTLFP 120 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEI 155 D + +W E H AD ++++ Y Sbjct: 121 DLDMAEWLECSRERHPADEKHTYPYSLHR 149 >UniRef50_Q11US6 Dihydrofolate reductase n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11US6_CYTH3 Length = 161 Score = 193 bits (490), Expect = 2e-48, Method: Composition-based stats. Identities = 62/162 (38%), Positives = 86/162 (53%), Gaps = 5/162 (3%) Query: 1 MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59 MI S+I A + +R IG+ N +PW+LPADL FK T+ +IMGR T+ESIG PLPGR + Sbjct: 1 MIRSIIVAQSENRAIGINNTLPWHLPADLKRFKAITMGHHMIMGRKTYESIGNPLPGRTS 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+++ T S+ EA + E VIGG + ++ + KLYLT I Sbjct: 61 IVVTRNKDLVFAGCTMAHSLAEAFEIAQNNNDSEAFVIGGAELIKEAINSCDKLYLTTIH 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT DW+ H D +N++SY F E+ Sbjct: 121 QNFEGDTFLDAL-ASDWKETEHVVHAPDDKNAYSYSFITYEK 161 >UniRef50_D2QWB5 Dihydrofolate reductase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2QWB5_9PLAN Length = 171 Score = 193 bits (490), Expect = 2e-48, Method: Composition-based stats. Identities = 59/159 (37%), Positives = 93/159 (58%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SLI A+ + +IG + +PW + ADL F+ T+ +IMGR TW+S+GR LPGR +I+ Sbjct: 11 LSLIVAMTREGLIGRDRDLPWKISADLKRFRSLTMGHTIIMGRTTWDSLGRALPGRTSIV 70 Query: 62 LSSQPG--TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ + + V S+DEAIA E +IGGG +Y Q + + Q+LY+T ++A + Sbjct: 71 LTRKADLVLPEGVLRAGSLDEAIALAAGDSEPFIIGGGEIYRQAMDRVQQLYVTWVEANI 130 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT FP ++P + + H A + ++ F ER Sbjct: 131 EGDTWFPAWDPSKFRLLEETSHPA-EGTTPAFTFTRYER 168 >UniRef50_Q54277 Dihydrofolate reductase n=84 Tax=Bacilli RepID=DYR_STAHA Length = 166 Score = 193 bits (490), Expect = 2e-48, Method: Composition-based stats. Identities = 62/158 (39%), Positives = 87/158 (55%), Gaps = 1/158 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A+ RVIG +N +PW + +D + K T +I+GR +SIGR LP R+NII Sbjct: 7 ISLIVAMDKKRVIGKDNDIPWRISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNII 66 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ + S++ A C + E+ + GG ++Y FLP +K+Y+T I E E Sbjct: 67 LTRDKNFNFKDCEIAHSIEAAFKLCENEEEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFE 126 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP DDW+ V E D +N + Y F I ER Sbjct: 127 GDTFFPVVNFDDWKEVSVEKGIKDEKNPYDYYFHIYER 164 >UniRef50_C0XLT5 Dihydrofolate reductase n=3 Tax=Lactobacillus RepID=C0XLT5_LACHI Length = 162 Score = 192 bits (489), Expect = 3e-48, Method: Composition-based stats. Identities = 57/160 (35%), Positives = 84/160 (52%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS I A + +IG +PW+LP D+A+FK+ T+ P+I G T+ S RPLPGR+NI Sbjct: 1 MISYIWAEDENGLIGASGNLPWHLPDDMAFFKKTTMGHPIISGARTFRSYNRPLPGRQNI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +LS D V + SV++ V GG ++ Q L K +LY T I + Sbjct: 61 VLSRHGDFPDGVLVISSVEQLCELVDKNPKENYFVTGGANLFGQLLDKVDRLYRTKIHHQ 120 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+ P+ + + V S D +N + + FE+ ER Sbjct: 121 FTGDTYMPEIKYAQFNQVTSIDGIVDERNRYPHTFEVFER 160 >UniRef50_Q5P234 Dihydrofolate reductase n=14 Tax=cellular organisms RepID=Q5P234_AZOSE Length = 167 Score = 192 bits (489), Expect = 3e-48, Method: Composition-based stats. Identities = 65/159 (40%), Positives = 92/159 (57%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +IAA A + IG +N +PW L +DLA FK T+ PV+MGR TWES+GRPLP R+N++ Sbjct: 8 VIIIAATARNGAIGRDNQLPWRLKSDLARFKETTIGHPVLMGRKTWESLGRPLPARRNLV 67 Query: 62 LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 ++ + A+ A GD + VIGG +Y Q L A L LT + A+V Sbjct: 68 VTRDRSYSATGAEVFPDPEAALEAAGD-ETVFVIGGAELYRQLLDSADALLLTEVHADVA 126 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD +FP ++ D++ V E HDADA N S+ F R+ Sbjct: 127 GDAYFPPFDRGDFDEVRREQHDADAHNEFSFDFVEYRRK 165 >UniRef50_B8KL97 Dihydrofolate reductase n=1 Tax=gamma proteobacterium NOR5-3 RepID=B8KL97_9GAMM Length = 182 Score = 192 bits (488), Expect = 4e-48, Method: Composition-based stats. Identities = 68/165 (41%), Positives = 98/165 (59%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+LI A A + VIG +NA+PW LP DLA FKR T+ KP++MGR T+ESIGRPLPGR NI+ Sbjct: 6 IALIVAAADNDVIGRDNALPWQLPGDLAHFKRTTMGKPILMGRLTYESIGRPLPGRTNIV 65 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +S PG V V+S+++A+ D E+M+IGG ++Y LP A ++YLT Sbjct: 66 ISRDPGYSAAGVRSVQSLEKALELAKDIAVIDGSSELMIIGGAQIYALALPLASRIYLTR 125 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + E GD P + W+ + + AD + ++ F R+ Sbjct: 126 VHVEPAGDAFLPAIDWAHWKESGRQENPADG-SVPAHTFLEYTRQ 169 >UniRef50_Q9RR65 Dihydrofolate reductase n=2 Tax=Deinococcus RepID=Q9RR65_DEIRA Length = 180 Score = 192 bits (488), Expect = 4e-48, Method: Composition-based stats. Identities = 64/160 (40%), Positives = 91/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 I IAA +RVIG + MPW+LPAD A F+ ++ KP IMGR ++++ R PLP R NI Sbjct: 17 IVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRKVFDTLRRKPLPERVNI 76 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ D S +EA+ GD PEI +IGG +Y + + +L +T I AE+ Sbjct: 77 VLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLYWDRLTRLEMTLIHAEL 136 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT FP+ P +WE F AD +N + F+ RR Sbjct: 137 DGDTFFPEIGP-EWELAQETFRPADEKNRYDLTFQTWRRR 175 >UniRef50_A3N0P3 Dihydrofolate reductase n=6 Tax=Pasteurellaceae RepID=A3N0P3_ACTP2 Length = 162 Score = 191 bits (487), Expect = 4e-48, Method: Composition-based stats. Identities = 79/161 (49%), Positives = 106/161 (65%), Gaps = 4/161 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A ++ VIG EN MPWNLP DLAWF++NTL KPVIMGR T+ESIGR LP R NII Sbjct: 3 ISLIVARTLNHVIGKENQMPWNLPVDLAWFRQNTLGKPVIMGRKTYESIGRLLPKRPNII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS + ++ +A + EIMVIGGG +++Q +P+A +LYLT I AE Sbjct: 63 LSRSGFCVEGAYTAQNFAQAAELAETFANTDEIMVIGGGELFKQTIPQADRLYLTEIQAE 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +EGDT F +++ +W V ++ + D QN++ F ILER+ Sbjct: 123 IEGDTLF-EFDESNWTLVEEKWSEIDEQNAYRCRFMILERK 162 >UniRef50_Q2K6G9 Dihydrofolate reductase protein n=3 Tax=Rhizobiales RepID=Q2K6G9_RHIEC Length = 172 Score = 191 bits (487), Expect = 4e-48, Method: Composition-based stats. Identities = 65/164 (39%), Positives = 100/164 (60%), Gaps = 7/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 ++IAA+A + IG E MPW L +DL FK TL KPV+MGR T++SIG+PLPGR N+++ Sbjct: 7 TIIAAVARNGTIGREGDMPWRLSSDLKRFKTLTLGKPVVMGRRTYDSIGKPLPGRPNVVI 66 Query: 63 SSQPGTDD-RVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 S Q D ++ S+ EA+ A EI +IGGG++Y Q + A ++Y+TH+ Sbjct: 67 SRQAAIDHSDISMAHSLAEALEAAERLALQTGAGEICIIGGGQIYAQAIDLADRMYITHV 126 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +A+++GD FP +P W++ A ++S+ F + ERR Sbjct: 127 EADLDGDAFFPAIDPGTWQAGEVVAVPAGERDSYPTRFVVYERR 170 >UniRef50_C3JBM5 Dihydrofolate reductase n=2 Tax=Bacteria RepID=C3JBM5_9PORP Length = 170 Score = 191 bits (487), Expect = 5e-48, Method: Composition-based stats. Identities = 51/159 (32%), Positives = 88/159 (55%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +S+I A+A + IG +N + W+LP DL FK T +IMG++T+ S+ LP R+NI Sbjct: 3 LSIIVAVAANNAIGKDNDLLWHLPGDLKRFKETTTGHAIIMGKNTFHSLPNGALPNRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 ++SS D V ++ A+ A E+ +IGG ++Y LP A K+Y + ++ Sbjct: 63 VVSSTLVPPDGVECYSTLQAALEAVAGEEEVFIIGGAQLYAASLPLADKIYFSRVEKGFP 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT+FP+++ +W + + D +N ++ I +R Sbjct: 123 EADTYFPEFDLTEWTPSYCTLYPEDERNEYAVTLTIYQR 161 >UniRef50_P04174 Dihydrofolate reductase n=33 Tax=Neisseriaceae RepID=DYR_NEIGO Length = 162 Score = 191 bits (487), Expect = 5e-48, Method: Composition-based stats. Identities = 63/157 (40%), Positives = 90/157 (57%), Gaps = 3/157 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I++IAA A + IG NAMPW++P D A+FK TL KPVIMGR TWES+ +PLPGR+NI Sbjct: 4 ITIIAACAENLCIGAGNAMPWHIPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNI 63 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S Q V S++ A+A C E +++GG ++Y Q +P A L +T +D V Sbjct: 64 VISRQADYCAAGAETVASLEVALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSV 123 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 EGD FP+ + W ++ +Y F Sbjct: 124 EGDAFFPEIDRTHWREAERTERRVSSK-GVAYTFVHY 159 >UniRef50_A1WMP6 Dihydrofolate reductase n=2 Tax=Proteobacteria RepID=A1WMP6_VEREI Length = 162 Score = 191 bits (486), Expect = 7e-48, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 85/161 (52%), Gaps = 7/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + LI A A + VIG + +PW+LP D+A F++ T VIMGR TW+S+ RPLPGR Sbjct: 3 LHLIYARAANGVIGKDGRLPWHLPQDMAHFRQLTQGCSVIMGRKTWDSLPARFRPLPGRS 62 Query: 59 NIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 NI+++ Q D S+++A+A C VIGG ++Y Q LP A + +T I+ Sbjct: 63 NIVVTRQSDWHADGARRAASLEQALALCDARQTAWVIGGAQLYAQALPLADCVEVTEINQ 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GD H P +W + Q+ ++ F R Sbjct: 123 DFDGDAHAPTLGA-EWVEIRRSRQP--DQHGLAFSFVRYAR 160 >UniRef50_A3HTR7 Dihydrofolate reductase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HTR7_9SPHI Length = 166 Score = 191 bits (485), Expect = 9e-48, Method: Composition-based stats. Identities = 58/161 (36%), Positives = 92/161 (57%), Gaps = 4/161 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLIAA+A + VIG N + W +P D FK T ++MGR T+ES+G+PLP R +++ Sbjct: 3 ISLIAAVAKNGVIGKGNDLVWKIPTDFKRFKAITSGNYILMGRKTFESLGKPLPNRTHLV 62 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +S + ++V++A C + ++ VIGGG +Y+Q + A +L +T +DA Sbjct: 63 ISRNKNYKVPEGHHLFENVEDAFIYCNKLGIEKLYVIGGGEIYKQTISIADELLITEVDA 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT+FP+ + + W+ V E +D N H + F ER Sbjct: 123 TPVGDTYFPEIDKNTWKIVSKESFPSDEINQHPFSFINYER 163 >UniRef50_C4FSY3 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FSY3_9FIRM Length = 169 Score = 189 bits (481), Expect = 2e-47, Method: Composition-based stats. Identities = 59/163 (36%), Positives = 91/163 (55%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M++L+ A IG +N +PW+LP DL +FK+ TL ++MGR T+ES+G R LPGR + Sbjct: 1 MLTLVYAQDQAGGIGYQNQLPWHLPNDLKFFKQVTLGHAILMGRKTFESMGCRLLPGRTS 60 Query: 60 IILSSQPGTD---DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+ Q + + V ++ EAI A + E+MVIGG ++ LP A ++ T I Sbjct: 61 YVLTRQEDYKSEIEGLHRVHNL-EAIKALAEDQEVMVIGGAEIFAALLPLADRVIRTQIK 119 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 A DT D + D W+ V + D +N +++ FE RR Sbjct: 120 ATFPADTFVADLDQDQWQCVEIQEGLVDDKNQYAHQFEWWVRR 162 >UniRef50_B3PTQ3 Dihydrofolate reductase protein n=49 Tax=Proteobacteria RepID=B3PTQ3_RHIE6 Length = 172 Score = 189 bits (480), Expect = 3e-47, Method: Composition-based stats. Identities = 64/164 (39%), Positives = 103/164 (62%), Gaps = 7/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 ++IAA+A + +IG + MPW L +DL FK TL KPV+MGR T++SIG+PLPGR N+++ Sbjct: 7 TIIAAVARNGIIGRDGDMPWRLSSDLKRFKALTLGKPVVMGRKTYDSIGKPLPGRPNVVI 66 Query: 63 SSQPGTD-DRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 S Q D V S+ EA+ A V EI ++GGG++Y Q + A ++ +TH+ Sbjct: 67 SRQAAIDHPDVAMAHSLAEAMDAAERLARETGVDEICIVGGGQIYAQAINLADRMCITHV 126 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +A+++GD FPD +PD W++ + A ++S+ + + +RR Sbjct: 127 EADLDGDASFPDIDPDLWQAAETIAVPAGEKDSYPTRYVVYKRR 170 >UniRef50_C6W5S3 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W5S3_DYAFD Length = 183 Score = 189 bits (480), Expect = 3e-47, Method: Composition-based stats. Identities = 62/161 (38%), Positives = 89/161 (55%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A A + IG +N + W L DL FK+ TL P+IMGR T+ESIG+PLPGR +I+ Sbjct: 20 ISIIVAAAENGAIGRDNQLLWRLSDDLKRFKQLTLGHPMIMGRKTFESIGKPLPGRTSIV 79 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D V V S+DEA+ D E+ ++GGG +YEQ A +YLT + Sbjct: 80 ITRNANFAFDGVVVVHSLDEALEKAKEIDSQEVCIVGGGEIYEQSQAIATHIYLTKVHTS 139 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V GDT F EP+ W H+ D ++ + F ++ Sbjct: 140 VVGDTFFSIREPEAWTETERISHEPDERHIFPFEFINYIKK 180 >UniRef50_B1XTJ0 Dihydrofolate reductase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XTJ0_POLNS Length = 162 Score = 189 bits (480), Expect = 3e-47, Method: Composition-based stats. Identities = 66/158 (41%), Positives = 93/158 (58%), Gaps = 5/158 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A + + VIG +N MPW + ADL +FKR T+ PVIMGR TWESIGR LPGR+NI+ Sbjct: 6 ISMIVARSRNHVIGRDNQMPWKISADLQFFKRVTMGHPVIMGRKTWESIGRSLPGRRNIV 65 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S V S+DEA+ + + P + VIGG +++ Q KA +LY+T ID ++E Sbjct: 66 VSRNASYPISGGELVGSLDEALKSLNEFPRVFVIGGEQLFRQAFDKADRLYITEIDLDIE 125 Query: 121 -GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 GDT F W+ V ++ ++ F LE Sbjct: 126 GGDTFFEVPNASAWKEVERTPG---SEGEITFSFITLE 160 >UniRef50_Q03S94 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=Q03S94_LACBA Length = 163 Score = 188 bits (477), Expect = 7e-47, Method: Composition-based stats. Identities = 54/162 (33%), Positives = 86/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+ + A + RVIG+ +PW+LPAD+ +FK T ++ G T+ S RPLP RKNI Sbjct: 1 MLIFLWAESQGRVIGLHGGLPWHLPADMHYFKTVTTGHTIVAGSKTFASFPRPLPNRKNI 60 Query: 61 ILSSQPGT--DDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++S QP T + V+ + S+ A AA +I V+GG +++ L LY T ID Sbjct: 61 VVSHQPATAFPENVSVLHSLPAVRAYAAARPQEKIFVVGGAQLFAGLLDDVDFLYRTRID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 A +GDT P + + + + + +N + + FE +R Sbjct: 121 AGFDGDTWMPVIDYSQFTLIDQQPGIRNEKNPYDFVFEQYQR 162 >UniRef50_A1TM51 Dihydrofolate reductase n=4 Tax=cellular organisms RepID=A1TM51_ACIAC Length = 165 Score = 187 bits (476), Expect = 1e-46, Method: Composition-based stats. Identities = 60/164 (36%), Positives = 86/164 (52%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + LI A A + IG+ NAMPW+LP DLA FK+ TL V+MGR TW+S+ RPLPGR Sbjct: 3 LRLIYARAANGGIGLHNAMPWHLPEDLAHFKQLTLGATVVMGRKTWDSLPARFRPLPGRT 62 Query: 59 NIILSSQPGTD-DRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 NI+++ Q G D S+++A+ + V+GG ++Y Q LP A + +T I Sbjct: 63 NIVVTRQAGWHADGALSASSLEQAVELARPHGDTVWVMGGAQIYAQALPMADGVEVTEIH 122 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQN-SHSYCFEILERR 159 + E D P P +WE A + + + F RR Sbjct: 123 RDFEADAFAPVLGP-EWEETARTPVQTSAGSAALPFSFVSYRRR 165 >UniRef50_C7X688 Dihydrofolate reductase n=7 Tax=Bacteroidales RepID=C7X688_9PORP Length = 165 Score = 187 bits (476), Expect = 1e-46, Method: Composition-based stats. Identities = 58/161 (36%), Positives = 84/161 (52%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 IS+IAA+A IG + ++P+D+ FK T VIMGR T+ES+ PLP RKN+ Sbjct: 4 ISIIAAIADKSAIGKNQQLLCHMPSDMKRFKELTTGHAVIMGRKTFESLPVAPLPNRKNV 63 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L++ P +S+ A+ C EI +IGG VY Q L A K+Y+T I E Sbjct: 64 VLTTMPEAGFVNCFACESMGAALDLCEKEDEIFIIGGALVYRQALRIADKMYITRIHHEF 123 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + + FP D WE E + AD +N + Y + R+ Sbjct: 124 PDATSFFPVVNWDLWEETEREEYPADEKNPYPYTYITYVRK 164 >UniRef50_B3ER85 Putative uncharacterized protein n=1 Tax=Candidatus Amoebophilus asiaticus 5a2 RepID=B3ER85_AMOA5 Length = 164 Score = 187 bits (475), Expect = 1e-46, Method: Composition-based stats. Identities = 65/163 (39%), Positives = 91/163 (55%), Gaps = 4/163 (2%) Query: 1 MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKN 59 MI S+I A AV+ VIG + +PW++PADL FK T VIMGR T+ES+ LP RK Sbjct: 1 MIKSIIVAKAVNHVIGNKGRLPWHMPADLKHFKELTGGHHVIMGRKTFESLPGSLPDRKI 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IILS + T V S++ A+ + E+ + GG VY + L K+YLT I Sbjct: 61 IILSQSLNYKVEDCTVVPSLEMALEIANQANETEVFIAGGAAVYREALGIVDKIYLTVIH 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +VEGDT FP + W V H+ D +++++Y F L +R Sbjct: 121 TDVEGDTFFPTLKDHQWTEVSIVSHNHDIKHAYAYDFIELAKR 163 >UniRef50_C6XMY9 Dihydrofolate reductase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XMY9_HIRBI Length = 182 Score = 186 bits (474), Expect = 2e-46, Method: Composition-based stats. Identities = 67/166 (40%), Positives = 93/166 (56%), Gaps = 8/166 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +++I A A + VIG++ +PW L DL +FK TL KPVIMGR TWES+ +PL GR N+ Sbjct: 15 LAMIVARAKNGVIGVDGDLPWRLKGDLKFFKSVTLGKPVIMGRKTWESLPFKPLKGRANL 74 Query: 61 ILSSQPGTDD-RVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLT 113 ++S + D S+ AIAA DV E+M+IGGG +Y LY+T Sbjct: 75 VVSRRHDFDAQGARVFPSLGVAIAAGRAIADQTDVEEVMIIGGGAIYTAAFENVDVLYVT 134 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ E EGDT FP+ + D W V H AD N H++ L R+ Sbjct: 135 EVNTEPEGDTFFPEIDDDVWTCVEETNHAADEDNDHAFVMRKLVRK 180 >UniRef50_C8X9J8 Dihydrofolate reductase n=1 Tax=Nakamurella multipartita DSM 44233 RepID=C8X9J8_NAKMY Length = 292 Score = 186 bits (473), Expect = 2e-46, Method: Composition-based stats. Identities = 65/160 (40%), Positives = 90/160 (56%), Gaps = 10/160 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A + VIG MPW++PADL FKR T+ P++MGR T+ES+G LPGR++I+ Sbjct: 8 VVLVAAVARNGVIGAAGTMPWHIPADLKRFKRLTMGHPMVMGRKTFESMG-LLPGRRSIV 66 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAA-CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++ P S+D AIA P +MV+GGG +Y Q LP+A +L +TH+D Sbjct: 67 ITRDPHWRAPGAEVADSLDRAIALGAQTDPVVMVVGGGEIYAQALPRADRLEITHLDLSA 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP +P W E D Y F RR Sbjct: 127 PGDTVFPAIDPALWAVTDREEADG-------YAFVTYRRR 159 >UniRef50_B8F4S8 Dihydrofolate reductase n=5 Tax=Pasteurellaceae RepID=B8F4S8_HAEPS Length = 165 Score = 186 bits (473), Expect = 2e-46, Method: Composition-based stats. Identities = 74/160 (46%), Positives = 105/160 (65%), Gaps = 4/160 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A +++VIG +NAM W+LP DLAWF+ NTL KPVIMGR T+ESIGR LP R NII Sbjct: 3 ISVIVARTLNKVIGKDNAMLWHLPVDLAWFRENTLGKPVIMGRKTYESIGRLLPKRPNII 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACG---DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 LS D S+++A+ + EIM++GGG +++Q +P A KLYLT I A Sbjct: 63 LSRSGFAIDGAYSAISLEQAVELAKNFANSDEIMILGGGELFKQTMPFADKLYLTEIQAN 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +EGDT F +++ W+ + ++ + D QNS+ F IL++ Sbjct: 123 IEGDTFF-EFDETQWQQIAEKWSEIDEQNSYRCRFMILDK 161 >UniRef50_A8YUW1 Dihydrofolate reductase n=12 Tax=Lactobacillus RepID=A8YUW1_LACH4 Length = 172 Score = 185 bits (470), Expect = 4e-46, Method: Composition-based stats. Identities = 56/167 (33%), Positives = 89/167 (53%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI + A IG++ +PW LPAD+A FK T+ P+IMGR T+ S+ R LP RK+I Sbjct: 1 MIEFVWAEDQKHQIGLDGHLPWRLPADMAHFKEKTIGHPIIMGRKTFMSLPRLLPQRKHI 60 Query: 61 ILSSQPGT------DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYL 112 +L+ +D+VT + S+ E + ++ +GG +++ L + L Sbjct: 61 VLTHDQDLKKKYQDNDQVTIINSIAELGDYIQNHQGEKLCTVGGVSIFKALLDQVDVLEK 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T IDA E DT P+ + D ++ V E H+AD +N + Y F +R+ Sbjct: 121 TEIDATFEADTVMPEIDYDQFKLVKKEHHEADEKNKYPYTFFTYQRK 167 >UniRef50_Q134B2 Dihydrofolate reductase n=10 Tax=Bradyrhizobiaceae RepID=Q134B2_RHOPS Length = 179 Score = 185 bits (470), Expect = 4e-46, Method: Composition-based stats. Identities = 65/164 (39%), Positives = 91/164 (55%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I +I A+A + VIG NA+PW L +D FK+ TLNKPVIMGR T++SIGRPLPGR NI+ Sbjct: 12 IVIIVAVAENGVIGEGNAIPWRLKSDQRRFKQLTLNKPVIMGRKTYQSIGRPLPGRTNIV 71 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 ++ V S + A E++V+GG +Y +LP+A + LT Sbjct: 72 VTRDTHFQAAGVVVAPSFEAAERVAAGDAMRRSATEVVVVGGSEIYAHWLPRATCIELTE 131 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GDT FP +PD WE V H A ++S + + R Sbjct: 132 VHASPQGDTTFPAIDPDQWEEVARTRHGAGPEDSVEFSYVTYRR 175 >UniRef50_C6W102 Dihydrofolate reductase n=1 Tax=Dyadobacter fermentans DSM 18053 RepID=C6W102_DYAFD Length = 167 Score = 185 bits (470), Expect = 5e-46, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 102/160 (63%), Gaps = 2/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+IAA++ + VIG+ N++PW+LP + A F++ T K IMGR ++E+ +N+I Sbjct: 7 LSIIAAMSENHVIGLNNSLPWHLPDEWAHFRKVTAGKAFIMGRKSFEAPDALHSEYRNVI 66 Query: 62 LSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S+P + RV + + + AIA D ++ V+GG V+EQ LP A ++YLT + A+V Sbjct: 67 ITSRPPAQAEPRVEYARDISGAIALLSDETDVFVLGGASVFEQMLPLADRMYLTIVHAQV 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP ++ DDW+ SEFH AD +++++ + R+ Sbjct: 127 EGDAFFPAFDSDDWQLADSEFHGADDDHAYAFSMNLYIRK 166 >UniRef50_D1QNC5 Dihydrofolate reductase n=1 Tax=Prevotella oris F0302 RepID=D1QNC5_9BACT Length = 160 Score = 184 bits (469), Expect = 6e-46, Method: Composition-based stats. Identities = 65/161 (40%), Positives = 95/161 (59%), Gaps = 4/161 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKN 59 ++SLIAA+A +R IG +N + +++ DL FKR T+ VIMGRHT+ES+ LP RKN Sbjct: 2 ILSLIAAVARNRAIGYQNRLLFHIKTDLEHFKRLTMGHVVIMGRHTFESLPNGALPHRKN 61 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++S + T V S EA+ C E+ VIGG +VY++ + +A +LYLT IDA Sbjct: 62 IVISKSVASFHGCTRVSSFKEALDMCQTEEEVFVIGGEQVYKEAITQADRLYLTEIDALA 121 Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E D +FP + + W V E H N ++ F + +RR Sbjct: 122 EQADAYFP--DYNSWHLVAHEAHKKSEDNPFAFAFTVYQRR 160 >UniRef50_B2TR57 Dihydrofolate reductase n=10 Tax=Clostridium RepID=B2TR57_CLOBB Length = 164 Score = 184 bits (468), Expect = 7e-46, Method: Composition-based stats. Identities = 58/162 (35%), Positives = 91/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+S+I A+A + VIG +N + W++ DL FK T K ++MGR T+ES+ LP RK+I Sbjct: 1 MLSIIVAIAKNNVIGNDNKLIWHISEDLKRFKEITSGKTIVMGRKTFESLPGVLPNRKHI 60 Query: 61 ILSSQPGTD---DRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IL+ + V + DE + + E+ +IGGG +Y+Q LP + KLYLT I+ Sbjct: 61 ILTRDKNFKVNSECVEIIYDFDELLNKYKNSDDEVFIIGGGEIYKQLLPYSNKLYLTKIN 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GDT+FP +D++ + D ++ Y F L R Sbjct: 121 KDFDGDTYFPQINYNDFKIDYESDVITDEKSGLEYKFINLSR 162 >UniRef50_UPI00017452A7 Dihydrofolate reductase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017452A7 Length = 167 Score = 184 bits (468), Expect = 7e-46, Method: Composition-based stats. Identities = 58/161 (36%), Positives = 82/161 (50%), Gaps = 11/161 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGR 57 + IAA+A +RVIG + +PW+LP DL +FK+ T PV+MGR T+ESI G+PLP R Sbjct: 11 LIAIAAMASNRVIGRDGTLPWHLPEDLKFFKKTTAGHPVLMGRKTFESIVAALGKPLPNR 70 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +NI+LSS + V + + + +IGG ++YE LP +L LT ID Sbjct: 71 RNIVLSSTLAPQEGVEVIPHLASLSQLSALTSPVYLIGGAQLYEALLPVCDELLLTWIDQ 130 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP + D+ H + F R Sbjct: 131 PYEGDAFFPAF-EGDFSLREVLGHGEG------FEFRRYVR 164 >UniRef50_D0XKH5 Dihydrofolate reductase n=1 Tax=Brevundimonas subvibrioides ATCC 15264 RepID=D0XKH5_9CAUL Length = 175 Score = 184 bits (468), Expect = 7e-46, Method: Composition-based stats. Identities = 66/169 (39%), Positives = 99/169 (58%), Gaps = 12/169 (7%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I+L+ A A + VIG + +PW L +DL FK+ TL KP IMGR TWES+ RPLPGR N+ Sbjct: 6 IALVVARARNGVIGRDGDLPWKLRSDLQRFKQITLGKPCIMGRSTWESLPLRPLPGRLNL 65 Query: 61 ILSSQPGTDD-----RVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQK 109 +LS ++ ++ +AI + + EI VIGG ++E LP+A++ Sbjct: 66 VLSRDLSYEERGKAKGAVVCSNLADAIDMARETAEDDGIDEICVIGGTALFEAALPRAKR 125 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LY+T ++AE EGD FP ++ + +E HDA ++ H + F IL+R Sbjct: 126 LYITEVEAEPEGDALFPAFDESLFAETLNERHDAGEKDDHPFVFRILDR 174 >UniRef50_Q5HPB1 Dihydrofolate reductase n=24 Tax=Bacilli RepID=DYR_STAEQ Length = 161 Score = 184 bits (467), Expect = 1e-45, Method: Composition-based stats. Identities = 56/159 (35%), Positives = 89/159 (55%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S+I A RVIG +N +PW+LP DL K+ T ++MGR T+ SIG+PLP R+N++ Sbjct: 3 LSIIVAHDKQRVIGYQNQLPWHLPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVV 62 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L++Q + V + S+DE + + GG ++E + + +Y+T ID + + Sbjct: 63 LTNQASFHHEGVDVINSLDEIKEL---SGHVFIFGGQTLFEAMIDQVDDMYITVIDGKFQ 119 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP Y ++WE S D +N+ + F L RR Sbjct: 120 GDTFFPPYTFENWEVESSVEGQLDEKNTIPHTFLHLVRR 158 >UniRef50_A6L1Q7 Dihydrofolate reductase n=34 Tax=Bacteroidales RepID=A6L1Q7_BACV8 Length = 164 Score = 183 bits (466), Expect = 1e-45, Method: Composition-based stats. Identities = 57/160 (35%), Positives = 91/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 IS+I A+A + IG EN + + LP DL FK T +IMGR T+ES+ + LP R+NI Sbjct: 3 ISIIVAIARNHGIGFENKLLYWLPNDLKRFKALTTGHTIIMGRKTFESLPKGALPNRRNI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAE 118 +LS + G +++ A++ C + EI +IGG +Y++ + AQ+LY+T I D Sbjct: 63 VLSRREGAVFAGAECFPALEIALSHCKEEEEIFIIGGASLYKEAMHIAQQLYITFIDDTS 122 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E D +FP+ + ++W+ E H D ++ + Y F R Sbjct: 123 KEADAYFPEIKKEEWKETGREDHPTDEKHLYPYSFINYSR 162 >UniRef50_B2I6E9 Dihydrofolate reductase n=11 Tax=Xanthomonadaceae RepID=B2I6E9_XYLF2 Length = 188 Score = 183 bits (464), Expect = 2e-45, Method: Composition-based stats. Identities = 72/163 (44%), Positives = 97/163 (59%), Gaps = 4/163 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 ++SLIAAL R IG +N +PW+LP DL FK TL +PV+MGR T S+GRPLPGR N+ Sbjct: 24 IVSLIAALDRYRAIGRDNGLPWHLPDDLKRFKALTLGRPVLMGRKTAHSLGRPLPGRTNL 83 Query: 61 ILSSQPGTD-DRVTWVKSVDEAI--AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+ + V S+D AI AA + VIGGG +Y LP A +YLTH+D Sbjct: 84 VLTRSGHVPFSEMRAVDSLDAAIVQAAAEGADTLSVIGGGELYALTLPHANAMYLTHVDV 143 Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V G DT+FP ++ DWE E H D ++++ + F RR Sbjct: 144 AVAGADTYFPMFDAVDWEIKNREPHQGDGRHAYPFTFIDYCRR 186 >UniRef50_C1IBP0 Dihydrofolate reductase n=1 Tax=Clostridium sp. 7_2_43FAA RepID=C1IBP0_9CLOT Length = 161 Score = 182 bits (463), Expect = 3e-45, Method: Composition-based stats. Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 2/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MISLI A+ + IG +N + ++ DL +FKR T ++MG +T+ S+ RPLP R+N Sbjct: 1 MISLIVAMDKNNGIGNKNKLLAHISEDLRYFKRVTDGNTIVMGYNTYMSLPKRPLPNRRN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+L+++ + V S++E + E + GG +Y Q LP A KLY+THI E Sbjct: 61 IVLTTKDIKLEGAVVVNSIEELLKLLNTEEETFICGGSSIYNQMLPYADKLYITHIFDEF 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT+FP+ D+WE S H + + H + F I + Sbjct: 121 EADTYFPEI-TDEWEISESFCHKENINHKHPHIFTIYTK 158 >UniRef50_Q1WU16 Dihydrofolate reductase n=5 Tax=Lactobacillus RepID=Q1WU16_LACS1 Length = 167 Score = 182 bits (463), Expect = 3e-45, Method: Composition-based stats. Identities = 56/167 (33%), Positives = 87/167 (52%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS + A IG + +PW LPADLA FK T+ P++MG+ T++S LP R++I Sbjct: 1 MISFVWAEDQKHQIGYKGHLPWRLPADLAHFKEVTMGHPMVMGKKTFDSFPGLLPRRQHI 60 Query: 61 ILSSQPGTDD------RVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYL 112 +L+ ++ +V + S+DE + + E+ VIGG ++ L K KLY Sbjct: 61 VLTHDTNLEEKYKDNPQVEIMNSIDELTSWLDENQFQEVSVIGGAMLFNLLLNKVDKLYK 120 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I +E GDT P D+++ V + D +N + Y F ER+ Sbjct: 121 TEILSEFNGDTVMPTINYDEFKLVSKKIGKVDEKNKYPYVFLEYERK 167 >UniRef50_C1SJK6 Dihydrofolate reductase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SJK6_9BACT Length = 156 Score = 181 bits (461), Expect = 5e-45, Method: Composition-based stats. Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 8/157 (5%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIIL 62 +LI A+ DRVIG N MPW+LP DL FK T + MGR T+ESIGRPLP R+N ++ Sbjct: 4 ALIVAMTKDRVIGKNNDMPWHLPEDLKLFKAKTTGHIIAMGRKTYESIGRPLPNRENFVI 63 Query: 63 SSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 + D SV E I A + + + IGGG++Y + ++++++I +G Sbjct: 64 TRSGKEYDGCRVFGSVQECIKAAEEYDKTLFFIGGGQIYSDAVDMVDEMHISYIKENYDG 123 Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 DT FP+++ W+ +E + + ++ R Sbjct: 124 DTFFPEFDESRWKVTETEEYG-------DFIYKKFVR 153 >UniRef50_C4L1C8 Dihydrofolate reductase region n=2 Tax=Exiguobacterium RepID=C4L1C8_EXISA Length = 162 Score = 181 bits (461), Expect = 5e-45, Method: Composition-based stats. Identities = 55/159 (34%), Positives = 89/159 (55%), Gaps = 3/159 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS + A +R IG +N + W LP DL FK T V+MGR T+ESIG+ LP R+NI Sbjct: 1 MISHVVAYGQNREIGKDNDLLWRLPDDLKHFKAITSGGTVVMGRKTFESIGKALPNRRNI 60 Query: 61 ILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++S + D+V +D +A E VIGG +YEQ +P ++Y T + A Sbjct: 61 VVTSDVSFSADQVEVWHDLDR-LAEMSQQEEWFVIGGAMLYEQTMPMTSRIYATEVAASF 119 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT++P+ + +W + H D +++++ F+ ++ Sbjct: 120 EADTYYPE-QTGEWSVTSTIDHPQDETHAYAFSFKQYDK 157 >UniRef50_B6INW3 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=B6INW3_RHOCS Length = 190 Score = 181 bits (460), Expect = 6e-45, Method: Composition-based stats. Identities = 67/166 (40%), Positives = 91/166 (54%), Gaps = 8/166 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + L+AA+A + VIG N +PW LP DL +FKR T+ KPV+MGR TWESIG +PLPGR NI Sbjct: 24 LVLVAAVARNGVIGRGNTLPWRLPGDLRFFKRTTMGKPVVMGRRTWESIGAKPLPGRCNI 83 Query: 61 ILSSQP-GTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+ + AIA PE+ VIGG ++ + L A +LYLT Sbjct: 84 VLTRDTGFAPEGAIVCHGFLGAIAEARSVAARTGAPEVCVIGGESLFAEALRMADRLYLT 143 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + AE GD FP ++ W E DA +S +Y L+R+ Sbjct: 144 EVLAEPAGDVLFPPFDRGAWMQTELERADAAGPDSPAYRILRLDRK 189 >UniRef50_A7IF75 Dihydrofolate reductase n=3 Tax=Rhizobiales RepID=A7IF75_XANP2 Length = 178 Score = 181 bits (460), Expect = 6e-45, Method: Composition-based stats. Identities = 55/165 (33%), Positives = 93/165 (56%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A++ + VIG + +PW LP+DL F+ T KP++MGR T+ESIGRPLPGR +++ Sbjct: 11 LALVVAVSQNGVIGTDGGLPWRLPSDLKRFRALTWGKPLLMGRRTYESIGRPLPGRTSVV 70 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLPKAQKLYLT 113 +S+ P + V S+++ + + EIMVIGG R++ LP A+ L+LT Sbjct: 71 VSTDPAFTVPEGVLKGASLEDGLRLADEAADAMGADEIMVIGGARLFHDTLPLARTLHLT 130 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GD FP ++ W + + ++ ++ L R Sbjct: 131 QVHAAPDGDVFFPAFDEAQWREIARDGPIQGEKDEAAFTALTLVR 175 >UniRef50_B2SDZ8 Dihydrofolate reductase n=19 Tax=Francisella RepID=B2SDZ8_FRATM Length = 180 Score = 181 bits (459), Expect = 8e-45, Method: Composition-based stats. Identities = 60/162 (37%), Positives = 91/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MISLI A + IG EN + W L DL FK+ T N ++MGR T+ESIGRPLP RKNI Sbjct: 15 MISLIVAYDKNFGIGKENTLAWKLSEDLKNFKKITENNYIVMGRKTFESIGRPLPNRKNI 74 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 IL+ D+ + S + + EI +IGG ++Y++FL A +LY+T +DA Sbjct: 75 ILTRDKDYKQDKCLIINSTQDILNFAESKPHYEIFIIGGAQIYKEFLKYADRLYITEVDA 134 Query: 118 EV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E+ + D FP ++ ++ + + D +N + F + E+ Sbjct: 135 EMTDLDAFFPQWDKSKYKRIGHKQFKKDDKNEFDFTFSVFEK 176 >UniRef50_A6GQA5 Dihydrofolate reductase n=1 Tax=Limnobacter sp. MED105 RepID=A6GQA5_9BURK Length = 188 Score = 181 bits (459), Expect = 9e-45, Method: Composition-based stats. Identities = 57/183 (31%), Positives = 92/183 (50%), Gaps = 26/183 (14%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++AA+A + +IG+ N++PW+LP DLA+FK+ TL PV+MGR T+ESI RPLPGR N++ Sbjct: 3 VSIVAAVAENGIIGINNSLPWHLPEDLAFFKQTTLGCPVLMGRKTYESINRPLPGRLNVV 62 Query: 62 LSSQPGTDD------------------------RVTWVKSVDEAIAACGDVPEIMVIGGG 97 LSS ++ ++ +A+ ++ +IGG Sbjct: 63 LSSNSDWKPAPGKDGTPRSVITHPAALPEGSATQIATATNLPDALNWLSSFEQVFLIGGS 122 Query: 98 RVYEQFLP--KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEI 155 +YEQ L +L LT I EGD FP ++ + V + A + + + F Sbjct: 123 NLYEQALAQGLVDELILTEIHQSFEGDASFPQWDRQQFREVDRITNTATPERAWGFDFVK 182 Query: 156 LER 158 + Sbjct: 183 YAK 185 >UniRef50_A4BS77 Dihydrofolate reductase n=1 Tax=Nitrococcus mobilis Nb-231 RepID=A4BS77_9GAMM Length = 162 Score = 180 bits (458), Expect = 1e-44, Method: Composition-based stats. Identities = 61/153 (39%), Positives = 88/153 (57%), Gaps = 1/153 (0%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 +A +RVIG + +PW LPAD+ F T KP++MGR ++IGR LPGR NI+LS P Sbjct: 1 MAENRVIGRAHGLPWRLPADMRHFVALTRGKPIVMGRRCHDTIGRALPGRHNIVLSRNPA 60 Query: 68 -TDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 V ++ A+A EIM+IGG ++Y FL +A ++YLT + VEGD FP Sbjct: 61 HRVPGCMLVHDLEAALAVAAGASEIMIIGGEQIYRLFLARADRIYLTLVHGRVEGDAFFP 120 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + +W+ + ADA N+++ F L RR Sbjct: 121 HLDAAEWQESARQSRLADADNAYALTFLTLLRR 153 >UniRef50_B6YRF0 Dihydrofolate reductase n=1 Tax=Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2 RepID=B6YRF0_AZOPC Length = 164 Score = 180 bits (458), Expect = 1e-44, Method: Composition-based stats. Identities = 56/160 (35%), Positives = 83/160 (51%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +S+IA+L + IG EN + LPADL F++ TL +IMGR T++S+ LP R+NI Sbjct: 3 LSIIASLGRNNEIGKENRLLCYLPADLKHFRKITLGHSIIMGRKTFDSLPNGILPDRENI 62 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S S+D A++ + E+ +IGG ++Y+Q LP LYLT + A Sbjct: 63 IISRNGSLAIKNARVYTSLDFALSKLMNEEEVFIIGGAQIYQQTLPIVNNLYLTKVYATF 122 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E D FP +W E A+ +N + F ER Sbjct: 123 PEADVFFPLINYSEWHETEQEKIPANTKNPYPISFTKYER 162 >UniRef50_C8NE93 Dihydrofolate reductase n=24 Tax=Lactobacillales RepID=C8NE93_9LACT Length = 169 Score = 180 bits (457), Expect = 1e-44, Method: Composition-based stats. Identities = 55/162 (33%), Positives = 87/162 (53%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M+ I A ++G + +PW LP DL +FK T+ + ++MGR T+E +G R LPGR+ Sbjct: 1 MLIYIWAQDERGLVGKDGTLPWRLPNDLKFFKEVTMGQTILMGRKTFEGMGSRLLPGRQT 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IIL++ V +++E + +I V GG +VY + LY T I A Sbjct: 61 IILTTSSDYIVPGAEVVTNIEEIVEDSR-HEDIYVCGGAQVYNLLKNHVELLYCTRIHAS 119 Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD++FP ++ D+ V S + D +N + + FEI ER+ Sbjct: 120 FEGDSYFPTEFPWHDFIKVKSLEGEIDEKNLYPHTFEIYERK 161 >UniRef50_Q6MID1 FolA protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MID1_BDEBA Length = 169 Score = 179 bits (456), Expect = 2e-44, Method: Composition-based stats. Identities = 51/172 (29%), Positives = 88/172 (51%), Gaps = 17/172 (9%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 +++ + A + +RVIG + +PW+LP D+ +F+ T +IMGR T++S GR LP R + Sbjct: 2 ILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRYH 61 Query: 60 IILSSQPG-------TDDRVTWVKSVDEAIAACGD-----VPEIMVIGGGRVYEQFLPKA 107 I+++ P V +V S++EA+ E+ +IGGG +Y+Q +P Sbjct: 62 IVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGDEVFIIGGGEIYKQAMPIT 121 Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 K+YLT I E GDT++P+ + + D + + F R+ Sbjct: 122 DKIYLTLIHREFPGDTYYPEIDEKVFTQTERR----DIETPIPFSFLTYLRK 169 >UniRef50_B9LR90 Dihydrofolate reductase region n=2 Tax=Halobacteriaceae RepID=B9LR90_HALLT Length = 194 Score = 179 bits (456), Expect = 2e-44, Method: Composition-based stats. Identities = 65/171 (38%), Positives = 94/171 (54%), Gaps = 14/171 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWES----IGRPLPGR 57 + L+AA+A +RVIG + MPW+ PADLA FKR T PVI+GR T+ES IG PLP R Sbjct: 21 LVLVAAVAENRVIGDDGGMPWHYPADLARFKRLTTGHPVIVGRATYESIADRIGGPLPDR 80 Query: 58 KNIIL-SSQPGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKL 110 +++L + + +DEA+ V ++ VIGG VYEQFL +A ++ Sbjct: 81 TSVVLTTRDLDLPEGAVVANDLDEAVDLAGADAADRGVDDVYVIGGATVYEQFLDRADRM 140 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNS---HSYCFEILER 158 LT + + +GDT FPD++ ++W E AD + + F ER Sbjct: 141 VLTEVPEQPDGDTRFPDWDDEEWVETEREVVGADGERGGEADALAFVTYER 191 >UniRef50_Q03F97 Dihydrofolate reductase n=2 Tax=Pediococcus RepID=Q03F97_PEDPA Length = 161 Score = 178 bits (453), Expect = 5e-44, Method: Composition-based stats. Identities = 57/161 (35%), Positives = 90/161 (55%), Gaps = 4/161 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS+I A + IG + ++PW++P D+A+FK+ T V+MGR T++SIG+ LP RKNI Sbjct: 1 MISMIWAEDLRHGIGKQQSIPWHIPGDMAFFKKTTSGNTVVMGRKTFDSIGKALPNRKNI 60 Query: 61 ILSSQP-GTDDRVTWVKSVDE--AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +LS P D V V S+ E AI + +IGG +Y L +A +L +T I Sbjct: 61 VLSHHPTSLPDSVVGVGSLSELQAIFETHPNEKFYIIGGSHLYNALLSQADELLITRIQK 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + + + PD ++++ S H++ +N +Y FE R Sbjct: 121 DYQCEVLAPDITQNEFKLASSVEHESTERNP-AYTFETWIR 160 >UniRef50_B9ECC1 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9ECC1_MACCJ Length = 164 Score = 178 bits (451), Expect = 7e-44, Method: Composition-based stats. Identities = 60/160 (37%), Positives = 93/160 (58%), Gaps = 5/160 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA++ + VIG + +PW +P + FK T+ K VIMGR T+ESIG+PLP RK I Sbjct: 2 IISLIAAISSNYVIGKDKDIPWKIPGEQVRFKDLTMGKSVIMGRKTFESIGQPLPNRKTI 61 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + + V+S++ A EI + GGG +Y++ LP A ++YLT I+ E Sbjct: 62 IISKSKDINYNNCLTVESLERAFNLLQQEDEIFIAGGGEIYKESLPFADRIYLTIIEKEY 121 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EG+ FP + D++E + + + Y + ER+ Sbjct: 122 EGNIFFPMFNKDEFEITYQQKV----EGFIPYTYFTYERK 157 >UniRef50_Q38WX9 Dihydrofolate reductase n=5 Tax=Lactobacillales RepID=Q38WX9_LACSS Length = 166 Score = 177 bits (450), Expect = 9e-44, Method: Composition-based stats. Identities = 52/163 (31%), Positives = 90/163 (55%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKN 59 MI+ + A + +IG + +PW LP DLA FKR T+N+ VIMGR T++S+ + PLPGR+N Sbjct: 1 MIAFLWAEDQNGLIGQDGHLPWRLPNDLANFKRETINEAVIMGRKTYDSLPKKPLPGRQN 60 Query: 60 IILSSQPGT--DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHI 115 I+++ Q G V + + + P ++ +IGG +++ F LY+T I Sbjct: 61 IVITRQSGLTVAKDVLVFNERTQLLDYQKEHPMQKLFIIGGADIFKLFAADVDYLYVTKI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GD + P + ++ + + D +N + + FEI +R Sbjct: 121 AEKFKGDVYMPTIDYTQFKLISQKAGAVDERNQYPHTFEIYQR 163 >UniRef50_Q2W7P5 Dihydrofolate reductase n=9 Tax=Bacteria RepID=Q2W7P5_MAGSA Length = 175 Score = 177 bits (449), Expect = 1e-43, Method: Composition-based stats. Identities = 73/162 (45%), Positives = 99/162 (61%), Gaps = 9/162 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A+A + VIG +NA+PW++P DL WFK NTL KPVIMGR TWESIGRPLP R NI+ Sbjct: 17 VALIVAVAANGVIGKDNALPWHIPEDLKWFKENTLGKPVIMGRKTWESIGRPLPKRPNIV 76 Query: 62 LSSQPGT-DDRVTWVKSVD----EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++ Q G + S+D A + E+MVIGG ++ + LP A++LYLT I Sbjct: 77 VTRQTGWRAEGAHTAHSLDEALALAARLAPEAAELMVIGGNSLFAEALPGARRLYLTEIA 136 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT FP +E W V ++ D ++ F IL+R Sbjct: 137 RAYEGDTMFPAFERGLWHEVSRRRNEGD----PAFDFVILDR 174 >UniRef50_B5EIA1 Dihydrofolate reductase region n=5 Tax=Geobacter RepID=B5EIA1_GEOBB Length = 306 Score = 177 bits (449), Expect = 1e-43, Method: Composition-based stats. Identities = 59/158 (37%), Positives = 91/158 (57%), Gaps = 4/158 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +IS IAAL+ +RVIG + +PW++P+DL F+ T+ VIMGR T+ESIG PL GR+NI Sbjct: 2 IISTIAALSDNRVIGADGGLPWDIPSDLTRFRSITMGHTVIMGRKTYESIGHPLLGRRNI 61 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +L+ + + ++V AIAA E+ + GGG V+++ LP Q+LYLT + Sbjct: 62 VLTRKGSQIEGCEIARNVPAAIAAAEGEEEVFICGGGEVFQEALPLCQRLYLTVVHGNYR 121 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GD P+ P+ + + E + F +LE+ Sbjct: 122 GDAFLPEL-PEGFVELHREEFP---DTTPPSSFVVLEK 155 >UniRef50_B6BUF2 Dihydrofolate reductase n=1 Tax=beta proteobacterium KB13 RepID=B6BUF2_9PROT Length = 148 Score = 176 bits (448), Expect = 2e-43, Method: Composition-based stats. Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 6/152 (3%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPG 67 ++ + VIG++N++PW+L DL FK T ++MGR T+ESIG+PLP R N +L+ Sbjct: 1 MSENNVIGIDNSLPWHLSGDLKRFKAITTGHQIVMGRKTYESIGKPLPNRVNFVLTRNSD 60 Query: 68 TD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 D V + S+++ + +IGGG +Y Q + +L +T I E+ GD FP Sbjct: 61 LKIDGVHVISSLNDI---SDSDKKTFIIGGGEIYSQLIDSCDELLVTKIHREIHGDAFFP 117 Query: 127 DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + W V + +N + + + Sbjct: 118 MIDASVWSLVDQ--SEKLNENDIEFSYLTYRK 147 >UniRef50_Q044A0 Dihydrofolate reductase n=13 Tax=Lactobacillus RepID=Q044A0_LACGA Length = 171 Score = 176 bits (447), Expect = 2e-43, Method: Composition-based stats. Identities = 60/167 (35%), Positives = 86/167 (51%), Gaps = 8/167 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI I A D IG + +PW+LPADL FK T N ++MGR T+ES LP R++I Sbjct: 3 MIRFIWAEDEDGHIGYQGTLPWHLPADLKHFKDLTSNHIIVMGRRTFESFPGLLPKRQHI 62 Query: 61 ILSSQP------GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYL 112 ILS+ P + V + E D E I +IGG RV+E+F+ + + Sbjct: 63 ILSTSPTLQRKYQNNAHVKIFSQLKELKNWIKDHSEQTIDIIGGARVFEEFMDEVDMIEK 122 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 T I +GDT P +D+E + ++ H AD +N +Y F ER+ Sbjct: 123 TKIHHVFKGDTLMPKINYEDFELINTKAHQADEKNKFAYDFLEYERK 169 >UniRef50_UPI0001C37DF3 dihydrofolate reductase n=1 Tax=Ruminococcus flavefaciens FD-1 RepID=UPI0001C37DF3 Length = 160 Score = 176 bits (447), Expect = 2e-43, Method: Composition-based stats. Identities = 60/161 (37%), Positives = 91/161 (56%), Gaps = 8/161 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MIS+IAA A + VIG +PW++P D+A+F+R T VIMGR T+E IGRPLPGR N+ Sbjct: 1 MISIIAAAAKNGVIGAGGKIPWDIPEDMAYFRRITYGGAVIMGRRTYEDIGRPLPGRFNV 60 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++S++ T + S+ EA+ G+ I + GG VY + L A ++YLT +D Sbjct: 61 VVSAKMQTAPEGTALAHSLAEAVEIAGNSGRENIFLCGGAAVYREGLAFADRIYLTILDK 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E GD +FP++ ++ E D+ F I ++ Sbjct: 121 EYSGDVYFPEFSEKEFRLTSYERCDSA-----PITFCIYDK 156 >UniRef50_Q0C500 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0C500_HYPNA Length = 176 Score = 176 bits (447), Expect = 2e-43, Method: Composition-based stats. Identities = 68/165 (41%), Positives = 89/165 (53%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + LI A A +R+IG A+PW L D+A+FK T+ PVIMGR TWES RPLPGR+NI Sbjct: 7 LCLIVAQARNRIIGAAGALPWRLKDDMAFFKATTMGAPVIMGRKTWESFPKRPLPGRENI 66 Query: 61 ILSSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +L+ D S A+ A E VIGG +Y LP A ++YLT Sbjct: 67 VLTRDWDYDAAEARVYSSFPAAMNAARAIAAREGKDEAFVIGGAEIYALALPFADRIYLT 126 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +DAE+EGDT FP+ + W S H A N H++ L+R Sbjct: 127 EVDAEIEGDTLFPELDLRQWRSDEIATHPAGEGNDHAFIIRRLDR 171 >UniRef50_B2ICT5 Dihydrofolate reductase n=2 Tax=Beijerinckiaceae RepID=B2ICT5_BEII9 Length = 198 Score = 175 bits (445), Expect = 3e-43, Method: Composition-based stats. Identities = 58/165 (35%), Positives = 89/165 (53%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++++AALA +RVIG+ AMPW+LP D F+ T KP++MGR T+ESIGR LPGR+ I+ Sbjct: 25 LTIVAALADNRVIGLNQAMPWDLPGDRRHFRERTWGKPMLMGRKTFESIGRALPGRETIV 84 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVPEIM------VIGGGRVYEQFLPKAQKLYLTH 114 L+ V ++ A+ D IM ++GGG ++ LP+ ++L LT Sbjct: 85 LTRDETFAAPGVLVAHDLEGALGLAHDWARIMGAKTIILVGGGELFAALLPRVERLELTL 144 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ +GDT FP + WE ++ SY F R+ Sbjct: 145 VEGNPKGDTFFPPIDWSQWEEEKRSGPLQGPNDTISYQFVDYHRK 189 >UniRef50_Q3BX85 Dihydrofolate reductase n=6 Tax=Xanthomonas RepID=Q3BX85_XANC5 Length = 164 Score = 175 bits (445), Expect = 3e-43, Method: Composition-based stats. Identities = 68/162 (41%), Positives = 95/162 (58%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LI A + IG +N +PW LP DL FK TL KP++MGR T +S+GR LPGR N++ Sbjct: 3 LTLIVAFDRNNAIGRDNELPWKLPDDLKRFKALTLGKPILMGRKTAQSLGRALPGRLNLV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ D + V SV++AI E+ VIGGG VY + +A L +T +D Sbjct: 63 LTRSGQVPFDGMQAVASVEQAIERAVQEGAQELCVIGGGEVYRLTMERADLLAVTEVDTA 122 Query: 119 VEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 V+G DTHFP +P W E H ADA+++H++ F ERR Sbjct: 123 VDGADTHFPPIDPAVWSPARRELHAADARHAHAFSFVDYERR 164 >UniRef50_Q5HFZ7 Dihydrofolate reductase n=54 Tax=Staphylococcus aureus RepID=DYR_STAAC Length = 159 Score = 175 bits (445), Expect = 4e-43, Method: Composition-based stats. Identities = 54/159 (33%), Positives = 91/159 (57%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +S++ A + RVIG EN +PW+LP DL K+ + ++MGR T+ESIG+PLP R+N++ Sbjct: 3 LSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVV 62 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+S + + V + S+++ + + GG ++E+ + K +Y+T I+ + Sbjct: 63 LTSDTSFNVEGVDVIHSIEDIYQL---PGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFR 119 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT FP Y +DWE S D +N+ + F L R+ Sbjct: 120 GDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 158 >UniRef50_C9MLK6 Dihydrofolate reductase n=2 Tax=Prevotella RepID=C9MLK6_9BACT Length = 161 Score = 175 bits (444), Expect = 5e-43, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 78/160 (48%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 +++IAA+A +R IG N M + + DL FK+ T VIMGR T+ S+ + LP R+NI Sbjct: 3 LNIIAAVAANRAIGYRNDMVYFIREDLKRFKQLTTGHTVIMGRKTFHSLPKGALPNRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI-DAEV 119 +LS S+DEA+ + +IGG +Y++ L A +LYLT I D Sbjct: 63 VLSRTEKDFKGCEVYPSLDEAMRHIHADEQAFIIGGASLYKEALGIANRLYLTEIADTPA 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D FP Y W E H A Y F R+ Sbjct: 123 QADVFFPPYNDGTWRVESREEHPATDDTP-PYSFVNYVRK 161 >UniRef50_UPI00016B2267 dihydrofolate reductase n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B2267 Length = 178 Score = 175 bits (444), Expect = 5e-43, Method: Composition-based stats. Identities = 65/162 (40%), Positives = 88/162 (54%), Gaps = 8/162 (4%) Query: 3 SLIAALAVDRVIGMENAMPW--NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 ++I A +R IG +PW +LPADLA FK+ T +IMG T+ESIG RPL RKN Sbjct: 17 AIIVAYDRNRAIGRGGDLPWGRSLPADLAHFKQLTKGGGIIMGHRTFESIGSRPLLERKN 76 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 I++SS+P + V V + A+A +IGG RVY L P+ +Y T IDA Sbjct: 77 IVISSRPTDSEGVLTVMDLPSALALSHYST--FIIGGARVYADALETPEIDTIYATEIDA 134 Query: 118 EVEG-DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 G DT FP+ + W+ H ADA N + + F I +R Sbjct: 135 SFPGADTFFPEIDMSIWQETSRIRHPADADNVYDFDFVIYKR 176 >UniRef50_Q1LSS4 Dihydrofolate reductase n=1 Tax=Baumannia cicadellinicola str. Hc (Homalodisca coagulata) RepID=Q1LSS4_BAUCH Length = 165 Score = 174 bits (443), Expect = 6e-43, Method: Composition-based stats. Identities = 81/160 (50%), Positives = 112/160 (70%), Gaps = 2/160 (1%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 +ISLIAA+ VDR+IG++N MPW+L DL WFK++T NKPVIMGR T+++I +PL GR NI Sbjct: 2 IISLIAAMTVDRIIGIKNTMPWHLYDDLIWFKKHTNNKPVIMGRKTFDAIKKPLSGRLNI 61 Query: 61 ILSSQ--PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +LS P D + WV + +A+ A G+V E+MVIGG ++Y F+ +A +LYLTHID Sbjct: 62 VLSRNFIPSRDQDIIWVDNPIKALIAAGNVTEVMVIGGAQIYNIFILQAHRLYLTHIDIN 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++GDT FP Y + W F ++H+ +N Y FEILER Sbjct: 122 IKGDTWFPHYHTNQWRVTFRKYHNDQEKNLPRYYFEILER 161 >UniRef50_A5VJL0 Dihydrofolate reductase n=8 Tax=Lactobacillus RepID=A5VJL0_LACRD Length = 162 Score = 174 bits (443), Expect = 6e-43, Method: Composition-based stats. Identities = 58/158 (36%), Positives = 86/158 (54%), Gaps = 4/158 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 ++LI A ++ IG +N +PW++ AD+ FK T P+IMGR T+ S+G +PLP R+NI Sbjct: 4 LNLIWAEDLNGWIGKDNTIPWHVSADMKHFKTKTTGHPIIMGRRTFASLGNKPLPKRENI 63 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+S+ + V V S+ + E VIGG +Y+Q LP A KL T I+ ++ Sbjct: 64 VLTSRNIDAEGVEVVHSLAALKEYLKANPNEYFVIGGATIYQQLLPMATKLTRTVINKQI 123 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 GDT P + D W V ++ D Q FE E Sbjct: 124 VGDTKMPTIDYDRWHLVNHNNYEKDDQ--LICRFEEWE 159 >UniRef50_Q0AN20 Dihydrofolate reductase n=4 Tax=Alphaproteobacteria RepID=Q0AN20_MARMM Length = 173 Score = 174 bits (443), Expect = 7e-43, Method: Composition-based stats. Identities = 60/165 (36%), Positives = 92/165 (55%), Gaps = 8/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + L+ A ++ VIG++ +PW L +DL FK T KP+IMGR TWES+ RPLPGR NI Sbjct: 8 LVLVVARGMNGVIGVDGDLPWRLSSDLRNFKAITSGKPIIMGRKTWESLPRRPLPGRLNI 67 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 +++ Q G + + EA+ A V E+ VIGG ++Y L +A +LYLT Sbjct: 68 VVTRQDGYVAEGGHVAGDLGEAMDAAFMRADADGVDEVCVIGGAQIYAATLERADRLYLT 127 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 ++A EG+T P+ + W E + A + H++ +L+R Sbjct: 128 EVEAAPEGETCLPEIDEALWRETRRELYPAGPGDDHAFMLRVLDR 172 >UniRef50_A6WGF8 Dihydrofolate reductase n=5 Tax=Actinomycetales RepID=A6WGF8_KINRD Length = 171 Score = 174 bits (441), Expect = 9e-43, Method: Composition-based stats. Identities = 60/162 (37%), Positives = 80/162 (49%), Gaps = 9/162 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MI L+ A + + VIG +PW +P DLA F T V+MGR TWES+ RPLPGR Sbjct: 1 MIGLVWAQSRNGVIGAGGRIPWRVPEDLAHFSALTAGSTVVMGRATWESLPARFRPLPGR 60 Query: 58 KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +N++LS PG + V + A+A ++ VIGG VY L A L +T +D Sbjct: 61 RNLVLSRDPGYAAEGAEVVHDLPGALA---GAGDVWVIGGSAVYRAALEHADVLVVTEVD 117 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGDT P+ P WE V A + + R Sbjct: 118 LVVEGDTRAPEVGP-GWERVEVGDW-ATSTGGPRFRIGTWRR 157 >UniRef50_A0PY39 Dihydrofolate reductase n=3 Tax=Clostridium RepID=A0PY39_CLONN Length = 170 Score = 174 bits (441), Expect = 1e-42, Method: Composition-based stats. Identities = 60/163 (36%), Positives = 92/163 (56%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL--NKPVIMGRHTWESIGRPLPGRK 58 M+S++ A+ + VIG ++++PW+LP DL +FK+ TL +K +IMGR T++S+ LPGRK Sbjct: 1 MLSIVVAIGKNNVIGKDHSLPWHLPNDLKYFKKVTLTESKTMIMGRKTFQSLKALLPGRK 60 Query: 59 NIILSSQPGT---DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +IIL+ D V + +D D E VIGGG ++ LP +K+Y+T I Sbjct: 61 HIILTKNKNFNMKDSNVEIINKIDMLKPIINDKKEYFVIGGGEIFSLLLPYTEKIYMTKI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP+ DW + D +N +++ F IL R Sbjct: 121 HHNFIGDTFFPNINRYDWNTTKEIQGITDEKNVYNHTFLILNR 163 >UniRef50_A4VUL2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=A4VUL2_STRSY Length = 170 Score = 174 bits (441), Expect = 1e-42, Method: Composition-based stats. Identities = 50/164 (30%), Positives = 88/164 (53%), Gaps = 6/164 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I I A + +IG + +PW+LPADLA FK+ T ++MGR T++ +G R LP R I Sbjct: 5 IVAIWAQDENGLIGKGDRLPWSLPADLAHFKKTTTGHTMVMGRITFDGMGKRALPNRHTI 64 Query: 61 ILSSQPGTD---DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116 +L++ +R+T + SV++ + + + VIGGG+++ F P + L +T I Sbjct: 65 VLTTDKTYQLESERITILHSVEDVLDWYNKQEQTLFVIGGGQIFTAFAPYIETLIVTDIH 124 Query: 117 AEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + GD +FP + + ++ + D +N + + + ERR Sbjct: 125 GQFNGDVYFPKAFPMEKFQLQSANLRPKDEKNPYDFTIKTYERR 168 >UniRef50_A0Z2N0 Dihydrofolate reductase n=2 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=A0Z2N0_9GAMM Length = 184 Score = 173 bits (440), Expect = 1e-42, Method: Composition-based stats. Identities = 59/164 (35%), Positives = 88/164 (53%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+ A++ + VIG NA+PW+LP DL FK+ T+ P++MGR T+ES+GRPLPGR N++ Sbjct: 13 VVLVLAVSENGVIGRGNALPWDLPDDLQHFKKATMGCPILMGRKTFESVGRPLPGRTNLV 72 Query: 62 LSSQPGT-DDRVTWVKSVDE------AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 L+ VT SVD+ A A + V+GG +Y LP+A ++ LT Sbjct: 73 LTRDSTWQAPGVTIFSSVDKALALAEAQALIDGASAVCVVGGAEIYRLCLPRADRILLTL 132 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +V GD F + W+ E A+NSH + R Sbjct: 133 VHGDVSGDATFDLSVLETWQEQRREHFPKGARNSHDFSVVEFVR 176 >UniRef50_C8WCM1 Dihydrofolate reductase region n=4 Tax=Zymomonas mobilis RepID=C8WCM1_ZYMMN Length = 165 Score = 173 bits (439), Expect = 2e-42, Method: Composition-based stats. Identities = 57/160 (35%), Positives = 86/160 (53%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LI A A + VIG +N MPW++ ADL FK TL P+IMGR T+ES+ LP R +I+ Sbjct: 7 IMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLPKRPHIV 66 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ + V ++EAI A +I VIGG +++QF KA ++ LT I + Sbjct: 67 LTHNHHWQAEGAEVVCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELTEIYRDY 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT + + + V E A+ + ++ F+ R+ Sbjct: 127 SGDTFVDLPDMNHFSLVGQEDFKAEGECP-AFSFKSFLRK 165 >UniRef50_A1SJ32 Dihydrofolate reductase n=1 Tax=Nocardioides sp. JS614 RepID=A1SJ32_NOCSJ Length = 160 Score = 173 bits (439), Expect = 2e-42, Method: Composition-based stats. Identities = 54/144 (37%), Positives = 81/144 (56%), Gaps = 2/144 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A + VIG +PW LP + FK T ++MGR T++SIGRPLPGR I+ Sbjct: 8 VVLVAAVARNGVIGDGPDIPWQLPGEQRLFKGLTWGHILVMGRATYDSIGRPLPGRTTIV 67 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ P + V + A+A + E+MV GGG+VY LP A + L+ +D E Sbjct: 68 LTRSPDWSAEGVHVAHDLPAALALADTLEGEVMVAGGGQVYAAALPVADEQVLSEVDLEP 127 Query: 120 EGDTHFPDYEPDDWESVFSEFHDA 143 +GD +P+++ +W E HD Sbjct: 128 QGDAFYPEFDRSEWRETAREQHDG 151 >UniRef50_B9XJM4 Dihydrofolate reductase n=1 Tax=bacterium Ellin514 RepID=B9XJM4_9BACT Length = 156 Score = 173 bits (438), Expect = 2e-42, Method: Composition-based stats. Identities = 58/128 (45%), Positives = 78/128 (60%), Gaps = 1/128 (0%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IAA++ +RVIG N +PW+LP D WFK+ T + V+MGR T+ESIGRPLP R+ I+ Sbjct: 4 FKAIAAMSQNRVIGQGNKIPWHLPEDFKWFKKMTTGQVVVMGRKTFESIGRPLPNRETIV 63 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 LS P V + + E I+ + EI + GG ++YEQ LP LYLT + VEG Sbjct: 64 LSRGPFQHPGVRTIFDLSE-ISLADESREIFICGGAQIYEQTLPMCSDLYLTVLKRTVEG 122 Query: 122 DTHFPDYE 129 D FP +E Sbjct: 123 DAFFPTFE 130 >UniRef50_Q0SWS9 Dihydrofolate reductase n=1 Tax=Clostridium perfringens SM101 RepID=Q0SWS9_CLOPS Length = 161 Score = 172 bits (437), Expect = 3e-42, Method: Composition-based stats. Identities = 57/161 (35%), Positives = 93/161 (57%), Gaps = 6/161 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M S+I A +++ +IG+ N +PWN+P+DL FK T+ K ++MGR T+ES+ LPGR ++ Sbjct: 1 MFSIIVAKSINNIIGVNNKIPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+++ V +D+ I+ D EI VIGGG++Y +FL A KLY+T + Sbjct: 61 VLTTKKDFSYNHKDVIIYNDLDKLISEYKDSMEEIFVIGGGKIYSEFLKYASKLYITEVL 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 E +GDT+FP + W + +N+ + + I E Sbjct: 121 KEYKGDTYFPKVDYSKWIKTYE--SSIYEENATKFKYVIYE 159 >UniRef50_D1PCZ0 Dihydrofolate reductase n=1 Tax=Prevotella copri DSM 18205 RepID=D1PCZ0_9BACT Length = 179 Score = 172 bits (436), Expect = 4e-42, Method: Composition-based stats. Identities = 59/181 (32%), Positives = 90/181 (49%), Gaps = 25/181 (13%) Query: 1 MISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRK 58 M+S+IA ++ R IG +N + + +P+D+ F+ T +IMGR T+ES+ LP R+ Sbjct: 1 MLSIIACISKVHRAIGYKNRLLYAIPSDMTRFRMLTTGHTIIMGRKTFESLPNGALPNRR 60 Query: 59 NIILSSQPGTDDRVTWVKSVDEAIAACGDV-------------------PEIMVIGGGRV 99 NI++S S++EA+AA + E +IGG + Sbjct: 61 NIVISKTREQITGCEVYTSLEEALAARKEEAARKEEVGNKETVGSKEASDECFIIGGASI 120 Query: 100 YEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 YEQ LP A KLYLT ++ E E DT FP+ P +WE E + +N + F L R Sbjct: 121 YEQALPFADKLYLTIVEKEPEHADTFFPEINPAEWEVTEKEMRN---ENGLPFTFLTLYR 177 Query: 159 R 159 + Sbjct: 178 K 178 >UniRef50_C7NFY1 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=C7NFY1_KYTSD Length = 337 Score = 171 bits (435), Expect = 5e-42, Method: Composition-based stats. Identities = 54/177 (30%), Positives = 82/177 (46%), Gaps = 28/177 (15%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A+A + IG + +PW+LP DL FK T+ ++MGR T+ES RPLPGR++++ Sbjct: 168 LTLVVAVARNGAIGRDGDLPWHLPGDLKHFKDTTMGGTMVMGRRTFESFPRPLPGRRHVV 227 Query: 62 LSSQPGTDDR----------------VTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLP 105 ++S P V +S EA+ GD E+ V+GG V+ LP Sbjct: 228 MTSDPTWLPGGPAVEGDPASGARFDEVLVARSWAEALLMAGDG-EVFVVGGAGVFADALP 286 Query: 106 KAQKLYLTHIDAEV-EGDTHFP---DYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 A +L LT +D + DT FP +P W + Y R Sbjct: 287 VADRLVLTEVDQSPQDADTFFPITWPVDPTVWHESSRTPGEG-------YAIVEYRR 336 >UniRef50_Q5V600 Dihydrofolate reductase 2 n=1 Tax=Haloarcula marismortui RepID=DYR2_HALMA Length = 167 Score = 171 bits (434), Expect = 6e-42, Method: Composition-based stats. Identities = 68/164 (41%), Positives = 86/164 (52%), Gaps = 14/164 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR----PLPGR 57 +SLIAA+A + VIG +PW P DL FK T+ PVIMGR T+ESI R PLP R Sbjct: 5 LSLIAAVAANGVIGAGGDIPWQYPEDLTHFKETTVGHPVIMGRRTFESIRRDLDGPLPER 64 Query: 58 KNIILSSQP-GTDDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTH 114 NI+L++ P D VT V S A+A D VIGG VYEQFLP+A +L LT Sbjct: 65 LNIVLTTTPHQLPDSVTAVTSTTAAVAEAADSDASTTYVIGGATVYEQFLPQADELILTE 124 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A +GDT FP + +W + H + R Sbjct: 125 LAAAFDGDTVFPTVDWSNWTEMERTTHSE-------FAIVRYTR 161 >UniRef50_A0JZC8 Dihydrofolate reductase n=11 Tax=Bacteria RepID=A0JZC8_ARTS2 Length = 194 Score = 171 bits (434), Expect = 7e-42, Method: Composition-based stats. Identities = 60/170 (35%), Positives = 84/170 (49%), Gaps = 14/170 (8%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + L+ A VIG + MPW+LP D+ F R T PVIMGR TW S RPLPGR Sbjct: 23 VGLVWAQTTAGVIGKDGDMPWHLPEDMKHFTRLTTGHPVIMGRKTWLSFPDKYRPLPGRT 82 Query: 59 NIILSSQPGTDD-----RVTWVKSVDEAI---AACGDVPEIMVIGGGRVYEQFLPKAQKL 110 NI+++ Q G D VKS+D+A+ + V+GGG ++ Q L A Sbjct: 83 NIVVTRQEGWGDTPDARGAIAVKSLDDALLESQFAPGHETVWVLGGGEIFAQTLDIADVA 142 Query: 111 YLTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158 +T ID+E +GDT+ P+ +W+ SE + Y F + R Sbjct: 143 VVTFIDSETDGDTYAPELGY-EWKLAASEPATGWLTSATGTRYRFTMWRR 191 >UniRef50_B8HHJ9 Dihydrofolate reductase n=2 Tax=Micrococcineae RepID=B8HHJ9_ARTCA Length = 181 Score = 171 bits (433), Expect = 9e-42, Method: Composition-based stats. Identities = 63/169 (37%), Positives = 90/169 (53%), Gaps = 12/169 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 +I +I A A + VIG + MPW+LP D F+R T VIMGR TWES+ RPLPGR Sbjct: 7 VIGMIWAQASNGVIGRDGTMPWHLPEDFEHFRRTTEGHSVIMGRRTWESLPEPFRPLPGR 66 Query: 58 KNIILSSQP-GTDDRVTWVKSVDEAIAACGDV---PEIMVIGGGRVYEQ--FLPKAQKLY 111 +N++++S P + S+ A+AA ++ +IGGG VY + FL A Sbjct: 67 RNLVITSDPAWSAPGAVRSSSILNALAAAAGQPGSDQVWIIGGGMVYREALFLRAANTAV 126 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158 +T I ++++GDT+ P+ PD WE +E A N Y E R Sbjct: 127 ITLIASDIDGDTYAPELGPD-WEMASAEPGVGWTTAANGTRYRIETWTR 174 >UniRef50_C6XGC7 Dihydrofolate reductase protein n=1 Tax=Candidatus Liberibacter asiaticus str. psy62 RepID=C6XGC7_LIBAP Length = 176 Score = 170 bits (432), Expect = 1e-41, Method: Composition-based stats. Identities = 58/164 (35%), Positives = 85/164 (51%), Gaps = 7/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LIAA+ + VIG MPW + +DL FK T PV+MG T++SIGR LPGR NII Sbjct: 6 IILIAAITRNNVIGSCGGMPWKISSDLKRFKSLTTGNPVVMGYRTFQSIGRLLPGRTNII 65 Query: 62 LSSQ----PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 ++ + S+ +++ +I +IGGG +Y Q + A LY+THI Sbjct: 66 ITRDNTRRASVNPEAVLASSILDSLDLASKTGSKKIFIIGGGEIYAQTISLAHTLYITHI 125 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFH-DADAQNSHSYCFEILER 158 + E+EGD FP + + W+ E A + + F I +R Sbjct: 126 EKEIEGDVFFPSIDSNIWKKQEKEIITSAGEGDDYPTRFVIYDR 169 >UniRef50_Q0TV23 Dihydrofolate reductase n=8 Tax=Clostridium perfringens RepID=Q0TV23_CLOP1 Length = 161 Score = 169 bits (430), Expect = 2e-41, Method: Composition-based stats. Identities = 54/162 (33%), Positives = 91/162 (56%), Gaps = 6/162 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M S+I A +++ +IG+ N MPWN+P+DL FK T+ K ++MGR T+ES+ LPGR ++ Sbjct: 1 MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +L+++ V +++ I+ D EI VIGGG++Y + L KLY+T + Sbjct: 61 VLTTKKDFSYNHKDVIIYNDLNKLISEYKDSMEEIFVIGGGKIYSELLKYTSKLYITEVL 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E +GDT+FP + W + +N + + F ++ Sbjct: 121 KEYKGDTYFPKVDYYKWIKTYE--SSIHEENGNKFKFFNYKK 160 >UniRef50_D1PWR8 Dihydrofolate reductase n=1 Tax=Prevotella bergensis DSM 17361 RepID=D1PWR8_9BACT Length = 163 Score = 169 bits (430), Expect = 2e-41, Method: Composition-based stats. Identities = 51/142 (35%), Positives = 79/142 (55%), Gaps = 2/142 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 IS+I A+A +R IG N + ++LP D+ FK T +IMGRHT++S+ L R+NI Sbjct: 3 ISIIVAMARNRAIGFRNHLLYHLPDDMKHFKALTTGHTIIMGRHTFDSLPNGALLHRRNI 62 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV- 119 ++S S+++AIA+C E+ +IGG +Y Q L A ++YLT +D Sbjct: 63 VVSRSRTHIVGCEVFGSLEQAIASCRGEQEVFIIGGESIYRQALAVAHRIYLTLVDDTPT 122 Query: 120 EGDTHFPDYEPDDWESVFSEFH 141 + DT FP+ + W+ E H Sbjct: 123 QFDTVFPEIDMSHWQETKKEKH 144 >UniRef50_A7SCT0 Predicted protein n=2 Tax=Nematostella vectensis RepID=A7SCT0_NEMVE Length = 187 Score = 169 bits (429), Expect = 2e-41, Method: Composition-based stats. Identities = 48/178 (26%), Positives = 77/178 (43%), Gaps = 21/178 (11%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51 S I A+ + R IG N +PW + D+ +F T VIMGR WESI Sbjct: 8 FSCIVAMDLKRGIGKNNDLPWKIKGDMKFFTEKTSEVKTEGKQNAVIMGRKVWESIPEKF 67 Query: 52 RPLPGRKNIILSSQPGTDD-RVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104 RPL GR NI+LS +S ++A+ + + V GG +Y+ + Sbjct: 68 RPLKGRLNIVLSRTLSEPPQGAQLCRSFEQALTILSTDPYTKKIENVFVCGGSALYKDAM 127 Query: 105 PK--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD--ADAQNSHSYCFEILER 158 ++Y+T+ID E + D FP+++ + + V + Y F + +R Sbjct: 128 AHSACTRIYITYIDQEFDCDVFFPEFDQNTYHLVEDPDVPSVQHEEKGIKYKFCVYDR 185 >UniRef50_C2MBL2 Dihydrofolate reductase n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MBL2_9PORP Length = 173 Score = 169 bits (429), Expect = 2e-41, Method: Composition-based stats. Identities = 60/163 (36%), Positives = 86/163 (52%), Gaps = 6/163 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I +I A A DR IG + MPW L DL K T VIMGRHTW+SIG RPLP R NI Sbjct: 3 IWIIVATARDRAIGRDGTMPWRLKDDLRRLKATTTGHAVIMGRHTWDSIGARPLPNRYNI 62 Query: 61 ILSSQ--PGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++S G + ++++A+ C + ++GGG +Y+ LP A L LT +D Sbjct: 63 VVSRTLPEGDAETHYVASTLEQALQHCQQAGYDRVYIMGGGVLYKSGLPYATHLNLTMVD 122 Query: 117 AEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V + DTHFP+ +W + + AD +N + + +R Sbjct: 123 TVVPDADTHFPEINLSEWSKLEEAHYPADERNDYPVTQTLYKR 165 >UniRef50_D0VXF2 Putative uncharacterized protein dfrP n=1 Tax=Bacillus phage phiNIT1 RepID=D0VXF2_9VIRU Length = 168 Score = 169 bits (429), Expect = 3e-41, Method: Composition-based stats. Identities = 56/161 (34%), Positives = 91/161 (56%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LIAA+ ++ IG +N + W++ D+ WF++ T NK V+MGR T+ESIG+PL GR N++ Sbjct: 3 VALIAAMGLNLEIGADNRLLWDIKEDMNWFRQKTKNKVVVMGRKTYESIGKPLKGRVNVV 62 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 L+ D V ++++ + EIMVIGG +Y QF P A ++YLT ++ Sbjct: 63 LTHNKEYDPHPDVLVRHNLEDIFFEFRNELEIMVIGGETIYNQFFPYANRIYLTQVEKTY 122 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E D FP+++ W F + D Y F + ++R Sbjct: 123 EEADAFFPEFDCSIWNRYF--YQDGSEDIGIKYNFSVYKKR 161 >UniRef50_Q14P23 Putative dihydrofolate reductase oxidoreductase protein n=1 Tax=Spiroplasma citri RepID=Q14P23_SPICI Length = 160 Score = 169 bits (428), Expect = 4e-41, Method: Composition-based stats. Identities = 45/164 (27%), Positives = 81/164 (49%), Gaps = 12/164 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI L+ A+ + +IG + +PW+L +L FK TL + ++ GR T+E IG PLP RK + Sbjct: 1 MIKLLWAMDENNLIGQNDQLPWHLREELQHFKETTLGQTILFGRLTYEGIGWPLPKRKTL 60 Query: 61 ILSSQPGT---DDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHI 115 +L+ V V + I +I + GG ++YE LP A +L ++ I Sbjct: 61 VLTRHLDYQIKHPDVEVVTDLTAIINFYHQNPTEDIYICGGKKIYEATLPYADELIISLI 120 Query: 116 DAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + +GDT+FP ++ + + + + + + +R+ Sbjct: 121 KGKYQGDTYFPSFDLNQFTLIKLNEYQQ-------FVIKYYKRK 157 >UniRef50_B7H0P5 Dihydrofolate reductase type 3(Dihydrofolate reductasetype III) n=19 Tax=Acinetobacter RepID=B7H0P5_ACIB3 Length = 181 Score = 168 bits (427), Expect = 4e-41, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 87/160 (54%), Gaps = 9/160 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A+ + IG NA+PW++ ADL FK T VIMGR T ES+GR LP R N +++ Sbjct: 11 VVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVIMGRKTLESMGRALPNRVNWVITR 70 Query: 65 QPGTD-DRVTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPKAQKLYLTHIDA 117 D V S+++A+ A + + + +IGGG +++Q L A +L LTH+D Sbjct: 71 DINWHFDGVKIAYSIEDALNAALEDAKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDL 130 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 +V+GD H+P P ++ SE D ++ S+ F + Sbjct: 131 DVQGDAHYPTI-PSEFHKTASEQ-QVDEKSGTSFEFATYK 168 >UniRef50_C7H0N2 Dihydrofolate reductase n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H0N2_9FIRM Length = 162 Score = 168 bits (427), Expect = 4e-41, Method: Composition-based stats. Identities = 49/162 (30%), Positives = 79/162 (48%), Gaps = 6/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 ++ I + + IG + + +L DL +FK T+ K +I+GR T ES +PLPGRK Sbjct: 1 MNAIVVVDKNWCIGKDGGLLVHLSKDLKYFKEKTIGKTLIVGRKTLESFPGGKPLPGRKT 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ + S E + D+ ++ V GGG +Y+QFL K ++T I Sbjct: 61 IVLTRNTSYKAEGAYVCHSKQEVLEKVKDLHPADVFVAGGGAIYKQFLNDVDKGFVTKIC 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E GDT FP+ + D+ + + +N + F I R Sbjct: 121 NEYSGDTFFPNLDEDE-DFALESEGETIEENGVKFKFCIYNR 161 >UniRef50_Q54801 Dihydrofolate reductase n=65 Tax=Streptococcus RepID=DYR_STRPN Length = 168 Score = 168 bits (427), Expect = 4e-41, Method: Composition-based stats. Identities = 57/162 (35%), Positives = 94/162 (58%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I I A + VIG EN +PW+LPA+L FK TLN ++MGR T++ +G R LP R+ + Sbjct: 5 IVAIWAQDEEGVIGKENRLPWHLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IL+ P D V + V + + + +IGG ++++ F P ++ +THI A Sbjct: 65 ILTRNPEEKIDGVATFQDVQSVLDWYQAQEKNLYIIGGKQIFQAFEPYLDEVIVTHIHAR 124 Query: 119 VEGDTHFP-DYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 VEGDT+FP + + +E+V S+F+ D +N + + + +R+ Sbjct: 125 VEGDTYFPEELDLSLFETVSSKFYAKDEKNPYDFTIQYRKRK 166 >UniRef50_Q18HG9 Dihydrofolate reductase n=4 Tax=Halobacteriaceae RepID=Q18HG9_HALWD Length = 195 Score = 168 bits (427), Expect = 5e-41, Method: Composition-based stats. Identities = 66/164 (40%), Positives = 89/164 (54%), Gaps = 18/164 (10%) Query: 6 AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNII 61 AA+A + +IG + MPW++PADL FKR T+ PVI+GR T+E+I G P PGR +I+ Sbjct: 37 AAVAANDIIGRDGEMPWHIPADLQQFKRRTMGHPVILGRRTYEAIIGALGEPFPGRTSIV 96 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGDVPE------IMVIGGGRVYEQFLPKAQKLYLTH 114 LSSQ V V S+ AI + V GGG VYEQFLP A +L LT Sbjct: 97 LSSQSRDVPADVILVHSITSAIREASKNARERGVGTVYVAGGGGVYEQFLPLADRLRLTE 156 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + E EGDT FP ++ W+ E ++ ++ F ER Sbjct: 157 LHDEYEGDTKFPSWDDTVWQETTREKNE-------TFDFVTYER 193 >UniRef50_Q5M5B2 Dihydrofolate reductase n=9 Tax=Streptococcus RepID=Q5M5B2_STRT2 Length = 167 Score = 168 bits (427), Expect = 5e-41, Method: Composition-based stats. Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKNI 60 I I A A + VIG + MPW+LPA+LA FK+ T+ ++MGR T++ + R LPGR+ + Sbjct: 5 IIAIWAEARNHVIGKNHTMPWHLPAELAHFKKTTMGSAILMGRVTFDGMNRRCLPGRETL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 IL+ D + VT V SV+EA+A ++ + GG VY+ F L T I+A+ Sbjct: 65 ILTRDKDFDCEEVTTVTSVEEALAWFEQQDKDLYIAGGASVYKAFDGHYDVLIKTTIEAD 124 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +EGDT+FP + ++ V + +N++ + E+ Sbjct: 125 LEGDTYFPQLDTTAFKEVSRNRVPKNEKNAYDFSISRYEK 164 >UniRef50_C3RMT4 Dihydrofolate reductase n=4 Tax=Bacteria RepID=C3RMT4_9MOLU Length = 156 Score = 167 bits (425), Expect = 7e-41, Method: Composition-based stats. Identities = 58/162 (35%), Positives = 95/162 (58%), Gaps = 11/162 (6%) Query: 1 MISLIAALAVDRVIGME---NAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGR 57 MI++I A D +IG + N MPWN+P DL FK TLNK ++MG T+++IGRPLP R Sbjct: 1 MINIIVATDEDLLIGKKDSRNGMPWNVPEDLQHFKATTLNKTILMGLTTYQAIGRPLPNR 60 Query: 58 KNIILSSQPGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 K I++S +P D+RV S++E I ++ + GG +Y+Q LP A +L ++ I Sbjct: 61 KTIVVSFEPFEDERVEVRSSLEEVIEEYRSSGEDLFISGGASIYKQCLPIADQLLISRIP 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EG+T+FP+++ ++ V + + ++ E +R Sbjct: 121 GKHEGETYFPNFDEYGYKLVAQKPFE-------TFTLETYKR 155 >UniRef50_Q59408 Dihydrofolate reductase type A13 n=57 Tax=Bacteria RepID=DYR13_ECOLX Length = 165 Score = 167 bits (425), Expect = 8e-41, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 81/160 (50%), Gaps = 6/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+AA+ +RVIG +PW +P + F+R T +K V+MGR T+ESIG+PLP R ++ Sbjct: 8 IYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVV 67 Query: 62 LSSQPGT-DDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS Q G V ++ + E+ V G VY LP A ++L+ + Sbjct: 68 LSRQAGYSAPGCAVVSTLSHVSPSTAEHGKELYVARGAEVYALALPHANGVFLSEVHQTF 127 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGD FP ++E V SE Q + +Y + RR Sbjct: 128 EGDAFFPVLNAAEFEVVSSE----TIQGTITYTHSVYARR 163 >UniRef50_Q9U8B8 Dihydrofolate reductase n=1 Tax=Heliothis virescens RepID=DYR_HELVI Length = 185 Score = 167 bits (424), Expect = 9e-41, Method: Composition-based stats. Identities = 54/179 (30%), Positives = 82/179 (45%), Gaps = 22/179 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51 ++LIAA + IG+ A+PW L ++A+F T VIMGR TW+ I Sbjct: 6 LNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTSKVSEPTKVNAVIMGRRTWDCIPDKY 65 Query: 52 RPLPGRKNIILSSQPGT-----DDRVTWVKSVDEAIAACGDVPEI---MVIGGGRVYEQF 103 RPL R NI+L+ + + V +DEAI +I VIGG +Y Sbjct: 66 RPLQDRVNIVLTHNVDSVKENVPEGVMVFPGLDEAIKYIEGREDIESTWVIGGSSIYRAA 125 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSE--FHDADAQNSHSYCFEILER 158 + P K+YLT I + DT FP+ + + V E + + + SY F + ++ Sbjct: 126 MTHPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQVEGNISYYFRVYKK 184 >UniRef50_P00380 Dihydrofolate reductase n=1 Tax=Enterococcus faecium RepID=DYR_ENTFC Length = 167 Score = 167 bits (424), Expect = 1e-40, Method: Composition-based stats. Identities = 49/162 (30%), Positives = 91/162 (56%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59 M + A + +IG + +PW LP D+ +F+ +T++K ++MGR T+E +G+ LP R Sbjct: 1 MFISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHI 60 Query: 60 IILSSQPGT--DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L++Q + + S+DE +A D+ +I V GG R+++ LP+ + ++ T ID Sbjct: 61 IVLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 AE EGDT + + +E V + +N + + F+ ++ Sbjct: 121 AEFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQKWQK 162 >UniRef50_C3XD45 Dihydrofolate reductase n=2 Tax=Oxalobacter formigenes RepID=C3XD45_OXAFO Length = 163 Score = 167 bits (423), Expect = 1e-40, Method: Composition-based stats. Identities = 55/160 (34%), Positives = 88/160 (55%), Gaps = 7/160 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS + A+A +RVIG + MPW++P + F+ T+ K +I+GR T ESIGR LP R II Sbjct: 4 ISHVVAMAENRVIGKDGQMPWHIPGEQKIFRELTVGKALILGRKTHESIGRVLPDRITII 63 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGD--VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S + + V +DEAI + +I++ GGG ++ Q LP K+YL+ + A+ Sbjct: 64 VSRKKDYEVPGAHVVHDIDEAIRLAREFGKEDIVIGGGGELFSQTLPVTDKVYLSIVHAD 123 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 +G+T +P+ +++ + DA Y F ER Sbjct: 124 FDGETFYPELPKEEFVEKARKEIDAS----IPYAFVEFER 159 >UniRef50_D2LGH8 Dihydrofolate reductase n=1 Tax=Rhodomicrobium vannielii ATCC 17100 RepID=D2LGH8_RHOVA Length = 178 Score = 167 bits (423), Expect = 1e-40, Method: Composition-based stats. Identities = 54/166 (32%), Positives = 86/166 (51%), Gaps = 9/166 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++L+ A A + VIG E +PW L +DL F+R T+ P+IMGR T+ SIG+PL GR ++I Sbjct: 9 LALVVAAAENDVIGREGKLPWRLKSDLKRFRRLTMGHPLIMGRKTFASIGKPLDGRDSVI 68 Query: 62 LSSQP---GTDDRVTWVKSVDEAIA------ACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 ++ V S+ +A+ A V E VIGG ++ LP A +++L Sbjct: 69 VTRDAASVSPQPGVFVATSIKDALDIARARAAERRVAEAFVIGGAEIFALALPYADRIHL 128 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + A GD ++ ++W+ V E A+ + S +LER Sbjct: 129 ARVHASPSGDAYWQAPPAEEWQVVSREEWPANQTDEFSVTDLVLER 174 >UniRef50_D0J8Z9 Dihydrofolate reductase n=2 Tax=Blattabacterium RepID=D0J8Z9_BLASP Length = 173 Score = 166 bits (422), Expect = 2e-40, Method: Composition-based stats. Identities = 57/172 (33%), Positives = 86/172 (50%), Gaps = 16/172 (9%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I LI+A++ + VIG N + W+LP DL FK T + V+MGR T+ESIG+ LPGR+NII Sbjct: 3 IILISAVSSNGVIGKNNQLMWHLPNDLKRFKNMTFGETVLMGRKTFESIGKILPGRRNII 62 Query: 62 LSSQPGTD--------------DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKA 107 L+ + S+ + + +I VIGG ++Y + KA Sbjct: 63 LTKKNKIHFFSSTNTNNKTNPRGTFEVYSSLKQIYDL--NYKKIFVIGGEKIYTSTIDKA 120 Query: 108 QKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + LT I + GD FP W+ + FH+ D + ++Y F ER+ Sbjct: 121 HIIELTVIHKKFYGDAKFPKIPLSKWKKTYEFFHEKDKHHLYNYSFIRYERK 172 >UniRef50_B1MYC2 Dihydrofolate reductase n=3 Tax=Leuconostoc RepID=B1MYC2_LEUCK Length = 166 Score = 166 bits (421), Expect = 2e-40, Method: Composition-based stats. Identities = 56/162 (34%), Positives = 86/162 (53%), Gaps = 4/162 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I ++ A IG + W+LP DL FK T+N ++MGR TW++IGRPLPGR +++ Sbjct: 4 IRMVWAEDSTHAIGKNGQLAWHLPDDLKLFKAETMNTLMVMGRTTWDTIGRPLPGRTSLV 63 Query: 62 LSSQPGTD---DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 L+ Q D V SVDE + + +I + GG +Y F+P A L +T ID Sbjct: 64 LTHQKDFKTPYDDVIIAHSVDEVLDYIEKETRDISIAGGAAIYHAFMPYATDLIVTRIDV 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + GDT + ++ V + HD D ++ +S+ E ER+ Sbjct: 124 TIAGDTFVDAIDLSQFKLVSATAHDKDDKHDYSFVVERYERQ 165 >UniRef50_Q1GFV5 Dihydrofolate reductase n=18 Tax=Rhodobacterales RepID=Q1GFV5_SILST Length = 163 Score = 166 bits (421), Expect = 2e-40, Method: Composition-based stats. Identities = 56/139 (40%), Positives = 83/139 (59%), Gaps = 6/139 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+LI A A + IG +N +PW+ P DL F+R TL +IMGR+TW+S+ +PL R N Sbjct: 1 MITLIVARARNGAIGKDNDIPWHAPEDLKAFQRETLGGAIIMGRNTWDSLPFKPLKNRFN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I++SS P D T V S+DEAI + IGG +Y+ L +A +L +T +D Sbjct: 61 IVVSSNPDAAD--TVVASLDEAIDLARSEGYARLYGIGGAGIYKGMLARADRLMITEVDL 118 Query: 118 EV-EGDTHFPDYEPDDWES 135 E+ + D FP++ P++W Sbjct: 119 EIDDADAFFPEFPPEEWRV 137 >UniRef50_UPI0001874368 dihydrofolate reductase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI0001874368 Length = 176 Score = 166 bits (421), Expect = 2e-40, Method: Composition-based stats. Identities = 58/160 (36%), Positives = 77/160 (48%), Gaps = 4/160 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + +I A + +IG MPW+LP DL FK T+ PVIMGR TW+S+ RPLPGR+ Sbjct: 15 VGMIWAQSRAGIIGDGATMPWHLPEDLQHFKTTTMGAPVIMGRRTWDSLNPKFRPLPGRR 74 Query: 59 NIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 NI+LS S++ A+AA D P +IGGGRVY L A + +T ID + Sbjct: 75 NIVLSRSVSDFPGAESATSLEAALAAVADEPAAWIIGGGRVYRDALSLADECVVTDIDTD 134 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 V + DW V Y F +R Sbjct: 135 VSVPVPVMAPDLYDWVRVEDGPWQTSTT-GLRYRFCTWQR 173 >UniRef50_C2HC06 Dihydrofolate reductase n=11 Tax=Enterococcus faecium RepID=C2HC06_ENTFC Length = 172 Score = 166 bits (421), Expect = 2e-40, Method: Composition-based stats. Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRP-LPGRKN 59 M + A + +IG +PW LP D+ +F+ +T+++ ++MGR T+E +G LP R Sbjct: 1 MFISMWAQDRNGLIGKNGLLPWRLPNDMRFFREHTMDRILVMGRKTYEGMGDLSLPYRHI 60 Query: 60 IILSSQPG--TDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L++QP T + + S+DE +A +I V GG R++++ LP +++ T ID Sbjct: 61 IVLTTQPNFRTKENAEVMHSIDELLAYSQTISEDIYVSGGSRIFQELLPYTGRIWRTLID 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + EGDT+ D + D+ + D +N +++ F+ ER Sbjct: 121 STFEGDTYIGDIDFSDFALIEEYEGITDQENLYAHRFQKWER 162 >UniRef50_C4Z3U6 Dihydrofolate reductase n=8 Tax=Firmicutes RepID=C4Z3U6_EUBE2 Length = 157 Score = 166 bits (421), Expect = 2e-40, Method: Composition-based stats. Identities = 52/161 (32%), Positives = 87/161 (54%), Gaps = 7/161 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI LI A + + VIG +PW + + +FK T+ V+MGR ++E IG PLP R+NI Sbjct: 1 MIGLIVARSKNNVIGRNGEIPWKIKGEQKFFKELTIGNIVVMGRKSYEEIGHPLPNRQNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I+S + + + V S+ EA+A D I + GG VY++ +P +Y+T +D + Sbjct: 61 IVSKTMKYEGENLITVSSLAEALA-LSDNSNIYIAGGYGVYKEAIPFVDVMYITEVDMNI 119 Query: 120 E-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E GD FP+++ +D++ + E + + Y R+ Sbjct: 120 EDGDVFFPEFDVNDFDLIIGETFGENTK----YTRTTYIRK 156 >UniRef50_Q6A328 Dihydrofolate reductase n=1 Tax=Pasteurella multocida RepID=Q6A328_PASMU Length = 169 Score = 165 bits (419), Expect = 4e-40, Method: Composition-based stats. Identities = 49/164 (29%), Positives = 77/164 (46%), Gaps = 8/164 (4%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRKN 59 SLI A+ R +G +N + W+LP D+ +FK T V+MGR +WESI RPLP R N Sbjct: 6 SLIVAIGKHREMGADNDLLWHLPRDMQFFKETTTGHAVVMGRKSWESIPQKYRPLPNRLN 65 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLP--KAQKLYLTHI 115 +L+ + T + + E +IGG ++Y+ L ++Y+T + Sbjct: 66 FVLTRDKNYSAEGATVIYDLKEVAQHLEGKNLTCFIIGGAQIYQLALETGLLNEMYVTQV 125 Query: 116 DAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E DT FP +WE D D ++ +S+ + R Sbjct: 126 HNTFEEADTFFPFVNWGEWEEEDILEQDKDEKHLYSFNIKKFTR 169 >UniRef50_Q8D3H9 FolA protein n=1 Tax=Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis RepID=Q8D3H9_WIGBR Length = 162 Score = 165 bits (419), Expect = 4e-40, Method: Composition-based stats. Identities = 70/159 (44%), Positives = 103/159 (64%), Gaps = 2/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI A + ++VIG + +PWNLP D++WFK+NT+NKPVIMGR T+ESI +PL R NI+ Sbjct: 3 ISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRINIV 62 Query: 62 LSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + + K+ +A+ + E+M+IGG ++Y+ FLPKA KLYLT I+AE+ Sbjct: 63 LSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINAEI 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 G+ FP Y W F ++ ++D +N +S F I + Sbjct: 123 NGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNK 161 >UniRef50_B2GC42 Dihydrofolate reductase n=4 Tax=Lactobacillus RepID=B2GC42_LACF3 Length = 167 Score = 165 bits (419), Expect = 4e-40, Method: Composition-based stats. Identities = 53/158 (33%), Positives = 81/158 (51%), Gaps = 4/158 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ I A IG +N MPW+L ADL FK T PVIMG++T+ S+GRPLP R NI+ Sbjct: 4 IAFIWAEDEAGWIGKDNDMPWHLSADLKHFKHLTSGHPVIMGKNTYLSLGRPLPKRTNIV 63 Query: 62 LSSQPGTDDRVTWVKS---VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ Q + VT V + + +A G+ E+ +IGG ++ + A LY T ++ + Sbjct: 64 VTRQTTPIEGVTLVNGVNALTDLLANYGEDEEVFIIGGAHLFASTMSLATVLYRTVVEGD 123 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 GD + W+ V E H ++ + FE Sbjct: 124 HHGDVKMAPIDYRTWQKVA-ERHLQATESDPACTFEKW 160 >UniRef50_UPI0001C35E5E dihydrofolate reductase region n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35E5E Length = 167 Score = 164 bits (417), Expect = 6e-40, Method: Composition-based stats. Identities = 48/164 (29%), Positives = 78/164 (47%), Gaps = 8/164 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + I A+ IG + + +LP D+ +F+ T K V+MGR T +S +PL R N Sbjct: 1 MKAIVAVDEAWGIGKDGKLLTHLPEDMKFFRTVTKGKVVVMGRKTLQSFPDAKPLKNRIN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+S + + + +SV +A+ D ++ +IGG VYEQFLP Y+T + Sbjct: 61 IVLTSDAALNGEGLIVCRSVADALRQLKEYDSDDVYIIGGQSVYEQFLPYCDTAYVTRMK 120 Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILERR 159 + DT F + + + WE E D + F + R Sbjct: 121 RDFGADTWFVNLDRQEGWEET--ETGDEKEYEGLHFTFCTYKNR 162 >UniRef50_C5NYS7 Dihydrofolate reductase n=1 Tax=Gemella haemolysans ATCC 10379 RepID=C5NYS7_9BACL Length = 163 Score = 164 bits (417), Expect = 6e-40, Method: Composition-based stats. Identities = 51/160 (31%), Positives = 88/160 (55%), Gaps = 1/160 (0%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M+SLI A ++ IG EN +PW L D+ K T N+ +IMGR T +SIGR LP R N Sbjct: 1 MLSLIVAYDKNKSIGQENTIPWRLKNDMLRVKELTTNQTIIMGRKTLDSIGRALPNRINR 60 Query: 61 ILSSQPGTDDRVTWVK-SVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +L+ + + ++ D++I + + + GGG +Y ++ K ++++T ++ V Sbjct: 61 VLTRDKDSLSHYSNIEVYTDDSILDNIETEKAYIFGGGMIYNKYFDKCDEMFITEVNTIV 120 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E DT FP+++ ++WE + E D N + F +R+ Sbjct: 121 EADTKFPEFDENEWELISREEFFKDENNEFDFVFIHFKRK 160 >UniRef50_C3Z0P2 Putative uncharacterized protein n=2 Tax=Deuterostomia RepID=C3Z0P2_BRAFL Length = 185 Score = 164 bits (417), Expect = 6e-40, Method: Composition-based stats. Identities = 53/179 (29%), Positives = 86/179 (48%), Gaps = 23/179 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 +SL+ A + IG++ +PW L D+ +F R T V+MGR TW SI Sbjct: 6 LSLVVAACNNMGIGVDGKIPWTLRGDMKFFSRLTSGTEEAGKQNAVVMGRKTWFSIPDRF 65 Query: 52 RPLPGRKNIILSSQPGTDDRV--TWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQF 103 RPLP R N++LS T S++EA+ + ++ +IGG VY+ Sbjct: 66 RPLPKRLNVVLSRNLTTPPEGAHHLAGSLEEAVKMLTETTVADTIDKVFIIGGNSVYKDA 125 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158 L P ++YLT + +V DT FP+ + D ++ V + + +N Y +E+ E+ Sbjct: 126 LSHPCCHRVYLTRVYKDVHCDTFFPNMD-DTFKLVSDPTIPSEMQEENGIEYKYEVYEK 183 >UniRef50_Q7UIC9 Dihydrofolate reductase n=1 Tax=Rhodopirellula baltica RepID=Q7UIC9_RHOBA Length = 195 Score = 164 bits (416), Expect = 9e-40, Method: Composition-based stats. Identities = 58/159 (36%), Positives = 85/159 (53%), Gaps = 3/159 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I+ + A + VIG + MPW L +DL FK+ T+ +IMGR T+ESIGR LPGR+ I+ Sbjct: 31 ITAVVAATPNGVIGDDQDMPWRLSSDLKRFKKATMGGALIMGRKTFESIGRVLPGRQTIV 90 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ Q EAIA D I V+GGG++Y+Q+ P +L+ T + A V Sbjct: 91 LTRQGHWQFPGTQTASGKSEAIALAAD-RRIFVVGGGQIYQQWFPLCTELWWTRVWANVS 149 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GDT D D++E V A++ + + + RR Sbjct: 150 GDTRV-DLPLDEFELVSQTSFPVTAKDDYPTDWLRMRRR 187 >UniRef50_B8DW85 Dihydrofolate reductase n=6 Tax=Bifidobacterium RepID=B8DW85_BIFA0 Length = 227 Score = 164 bits (415), Expect = 1e-39, Method: Composition-based stats. Identities = 64/181 (35%), Positives = 89/181 (49%), Gaps = 24/181 (13%) Query: 2 ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RP 53 ++LI A A D IG E MPW+LP DL FK T++ PVIMGR TWE++ RP Sbjct: 37 VNLIWAQANDKEGRSGAIGYEGEMPWHLPEDLKRFKELTVSHPVIMGRKTWEALNEKFRP 96 Query: 54 LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103 LP R NI+LS T V +++EA+ D EI VIGG +++ Q Sbjct: 97 LPNRDNIVLSRDRDFRAPGATVVDNLEEALDMARQEAIPDDGLDRSEIWVIGGSQLFNQM 156 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPD----YEPDDWESVFSEFH--DADAQNSHSYCFEILE 157 LP A K+Y+T +DA+V D + PD W+ + + + Y + E Sbjct: 157 LPMASKIYMTQVDAKVNADAYAPDLTEALNNGSWKLMENSGWLTPKKPEGIDRYRYLTFE 216 Query: 158 R 158 R Sbjct: 217 R 217 >UniRef50_UPI00016BFCBD Dihydrofolate reductase n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFCBD Length = 161 Score = 164 bits (415), Expect = 1e-39, Method: Composition-based stats. Identities = 56/154 (36%), Positives = 94/154 (61%), Gaps = 4/154 (2%) Query: 4 LIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 +I A++ + IG+ N +PWN+ D+ +F++ T K VIMGR T+ SIGRPLP R+NI+L+ Sbjct: 1 MIVAVSKNGQIGIANELPWNIKEDMNYFRKMTTAKTVIMGRKTFNSIGRPLPNRRNIVLT 60 Query: 64 SQPGTD-DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGD 122 + V V + EA+ + + VIGGG++YE F+P A++LY+T +D +++GD Sbjct: 61 TNTDLKIAGVEVVTNFAEALIIARE-EDAFVIGGGQIYELFMPYAEELYITEVDIDIDGD 119 Query: 123 THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 FP+Y + + V + A+ + ++Y F Sbjct: 120 AAFPEY-RNKFVCVETIEKSAN-DSKYNYRFTKW 151 >UniRef50_D1BYH5 Dihydrofolate reductase n=1 Tax=Xylanimonas cellulosilytica DSM 15894 RepID=D1BYH5_XYLCX Length = 185 Score = 164 bits (415), Expect = 1e-39, Method: Composition-based stats. Identities = 59/185 (31%), Positives = 81/185 (43%), Gaps = 26/185 (14%) Query: 1 MISLIAALAVDR----VIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLP 55 MI+LI A A D VIG +PW + D F+ T PV+MGR TW+S+ RPLP Sbjct: 1 MIALIWAQARDTAGRPVIGAGGDIPWRVAEDFTRFRTLTTGHPVVMGRRTWDSLPRRPLP 60 Query: 56 GRKNIILSSQPGTDDR---------------VTWVKSVDEAIA---ACGDVPEIMVIGGG 97 GR N++++ QP V ++DEA+ + +IGG Sbjct: 61 GRTNVVVTRQPDWRPDDDGAVVTAGAPEATAVVVATTLDEALDGATQAPGGDLVWIIGGA 120 Query: 98 RVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADA---QNSHSYCFE 154 +Y Q L A +L +T ID V+GD P +P W D + S Y F Sbjct: 121 EIYGQALAVADRLEVTEIDLVVDGDAFAPAIDPVHWHEGQHGHGDWVSPARPESPRYRFR 180 Query: 155 ILERR 159 RR Sbjct: 181 TYVRR 185 >UniRef50_A3K5B9 Dihydrofolate reductase n=1 Tax=Sagittula stellata E-37 RepID=A3K5B9_9RHOB Length = 153 Score = 163 bits (414), Expect = 2e-39, Method: Composition-based stats. Identities = 60/142 (42%), Positives = 81/142 (57%), Gaps = 7/142 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MI+LIAA +R IG + +PW++P DLA FKR TL ++MGR TWES+ +PL R N Sbjct: 1 MITLIAAHDRNRAIGKDGDIPWHIPEDLAMFKRETLGGAIVMGRKTWESLPFKPLKDRLN 60 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I++S + V SV++AIA I IGG R+YE LP A +L +T +D Sbjct: 61 IVVSRDTSLHE--HVVGSVEDAIALAQSQGYFRIYGIGGQRIYEAMLPLAHRLLITEVDT 118 Query: 118 EV-EGDTHFPDYEPDDWESVFS 138 V E D FPD + W V + Sbjct: 119 VVEEADAFFPDVG-EGWREVST 139 >UniRef50_Q89AV2 Dihydrofolate reductase n=5 Tax=Buchnera aphidicola RepID=DYR_BUCBP Length = 164 Score = 163 bits (414), Expect = 2e-39, Method: Composition-based stats. Identities = 71/160 (44%), Positives = 106/160 (66%), Gaps = 3/160 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS+I A++ + VIG +N++PWN+P DL+WFK++T+ K +IMGR TWESIGR LP R+NI+ Sbjct: 3 ISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQNIV 62 Query: 62 LSSQPGTDD-RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 L+ Q + V +V S+ +AI + EIM+IGG +Y Q L A KLY+THI+ + Sbjct: 63 LTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKYIL 122 Query: 121 GDTHFPDYEPDDWESVFSEFHDADA--QNSHSYCFEILER 158 GDT+FP Y+ W+ +F + +NS F+IL++ Sbjct: 123 GDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKK 162 >UniRef50_Q3A0W8 Dihydrofolate reductase n=1 Tax=Pelobacter carbinolicus DSM 2380 RepID=Q3A0W8_PELCD Length = 167 Score = 163 bits (413), Expect = 2e-39, Method: Composition-based stats. Identities = 54/159 (33%), Positives = 82/159 (51%), Gaps = 8/159 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++++ A+ +R+IG +PW++P DLA F+R T ++MGR T+ESIGRPLPGR NI+ Sbjct: 16 MTIVVAMTAERIIGRRGQLPWSIPEDLALFRRLTYGHTLVMGRRTFESIGRPLPGRFNIV 75 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE 120 +S + + + EA+ +I IGG +Y Q L A KL ++ I Sbjct: 76 VSRSMPPVEGLRVCRHFAEALQVADQGNGDIFFIGGCEIYRQALIVAGKLSVSWIRKNYP 135 Query: 121 GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD FP+Y DDW + + + I RR Sbjct: 136 GDCRFPEYRSDDWLIEQEQDYSE-------FRHIIYRRR 167 >UniRef50_B0MRL8 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MRL8_9FIRM Length = 161 Score = 163 bits (413), Expect = 2e-39, Method: Composition-based stats. Identities = 49/161 (30%), Positives = 78/161 (48%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 + +I A+ + IG + + +L DL K T+ ++MG T+ S RPLP R+N+ Sbjct: 1 MEIIVAVDENYGIGKDGDLLAHLSPDLKRLKAMTVGNIIVMGSKTYMSFPKRPLPDRENL 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 I++ P + VDE + + I V+GGG VYEQ LP +K ++T I Sbjct: 61 IITHHPENYPGIKCFTGVDEFLEYSKTADKPIFVLGGGSVYEQLLPYCEKAHITKILHSF 120 Query: 120 EGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159 E DT FP+ + + DWE E + + + + RR Sbjct: 121 EADTFFPNLDNNPDWEKENEEDIVTGEK--YPFRYVTYVRR 159 >UniRef50_C5CC92 Dihydrofolate reductase n=3 Tax=Actinobacteria (class) RepID=C5CC92_MICLC Length = 186 Score = 163 bits (413), Expect = 2e-39, Method: Composition-based stats. Identities = 62/176 (35%), Positives = 85/176 (48%), Gaps = 19/176 (10%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 +I++I A RVIG + MPW++P DLA F+ +T PVIMGR TWES RPLPGR Sbjct: 11 VIAMIWAQTPGRVIGRDGTMPWHVPEDLAHFRAHTHGHPVIMGRRTWESFPARFRPLPGR 70 Query: 58 KNIILSSQPGTDD---------RVTWVKSV---DEAIAACGDVPEIMVIGGGRVYEQFLP 105 NI++S + V A A + VIGG +Y+Q L Sbjct: 71 TNIVVSRTLTATEQAGAQLRAAGAVVVPDFGAALAAAAEADGCDTVWVIGGATLYDQALD 130 Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD---ADAQNSHSYCFEILER 158 A + +T IDA+V+GDTH P + W + D+ + + FE ER Sbjct: 131 VASRAEVTVIDADVDGDTHAPPLDA-RWRRTAVDPAPDAWLDSASGPRHRFERWER 185 >UniRef50_B2UP70 Dihydrofolate reductase n=1 Tax=Akkermansia muciniphila ATCC BAA-835 RepID=B2UP70_AKKM8 Length = 159 Score = 162 bits (411), Expect = 3e-39, Method: Composition-based stats. Identities = 59/154 (38%), Positives = 83/154 (53%), Gaps = 8/154 (5%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSS 64 + A+A DR IG A+PW+LP DL FKR T PV+MGR T+ESIGRPLPGR+NI+L+ Sbjct: 10 VVAMAPDRGIGYRGALPWHLPDDLKTFKRITTGHPVLMGRKTYESIGRPLPGRQNIVLTR 69 Query: 65 QP-GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDT 123 P T + V V S E PEIMVIGG ++ +P +++++ + E DT Sbjct: 70 DPAWTAEGVQVVHSAGELECLELMDPEIMVIGGAEIFSLMMPAMSRMWVSKVKGEYPADT 129 Query: 124 HFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 P +E +V E + + + E Sbjct: 130 FLPPFENRLERAVLKEHFE-------DFDLYLYE 156 >UniRef50_C7R3F1 Dihydrofolate reductase n=1 Tax=Jonesia denitrificans DSM 20603 RepID=C7R3F1_JONDD Length = 191 Score = 162 bits (411), Expect = 3e-39, Method: Composition-based stats. Identities = 56/164 (34%), Positives = 79/164 (48%), Gaps = 10/164 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 +SLI A +++ VIG +PW+ P DLA F++ T VIMGRHTWES+ PLP R NI Sbjct: 11 LSLIWAQSLNGVIGRSGTIPWHEPTDLAHFQKTTRGGVVIMGRHTWESLPVTPLPQRVNI 70 Query: 61 ILSSQPGT-DDRVTWVKSVDEAIAACG-----DVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 +L+S V + +A+ I VIGG +VY+ F+ A +L +T Sbjct: 71 VLTSDRDYRAPGARVVTTPQQALDLAHWYTQVGHQAIWVIGGRQVYDTFMDYATQLIVTT 130 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +EGDT P P V E H + + R Sbjct: 131 VGTVIEGDTEAPRIPP---HFVPQEPHQLATHSDYEVTVTTWLR 171 >UniRef50_Q3F0Y0 Dihydrofolate reductase n=2 Tax=Bacillus thuringiensis RepID=Q3F0Y0_BACTI Length = 172 Score = 162 bits (411), Expect = 3e-39, Method: Composition-based stats. Identities = 57/171 (33%), Positives = 82/171 (47%), Gaps = 12/171 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 MISLI A + IG EN + L D+ F + T KP+IMG T+ S+G +PL R N Sbjct: 1 MISLIVAADENNAIGFENKLLCRLKDDMKHFIKKTKGKPIIMGYKTFASLGHKPLKDRFN 60 Query: 60 IILSSQP--------GTDDRVTWVKSVD--EAIAACGDVPEIMVIGGGRVYEQFLPKAQK 109 I+L+ P +S++ + + EI+VIGG + YE FLP A + Sbjct: 61 IVLTRSPMALTLDHLHLVGENLVFESLEYIQFMIEQSKDKEIVVIGGQQTYELFLPMASR 120 Query: 110 LYLTHIDAEV-EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +YLT I E D++FP + +W S H N H + ER+ Sbjct: 121 VYLTRIHHSFPEADSYFPMLDSSEWSSKLDAKHAESEDNDHPFSIYTFERK 171 >UniRef50_C4Z7Z2 Dihydrofolate reductase n=34 Tax=Bacteria RepID=C4Z7Z2_EUBR3 Length = 163 Score = 162 bits (410), Expect = 4e-39, Method: Composition-based stats. Identities = 47/163 (28%), Positives = 80/163 (49%), Gaps = 8/163 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 ++LIAA+ + IG N + +P D +F+ T K V+MGR T ES RPL R N Sbjct: 1 MNLIAAVDNNWAIGKNNQLLVRIPMDQKFFREMTTGKVVVMGRKTLESFPNSRPLKNRTN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 I+L+ P + + V S+DE + +I +IGG ++YEQ + + ++T +D Sbjct: 61 IVLTHNPSYEVEGAVVVHSLDELHKELEKYNSEDIYIIGGQKIYEQLVDECDVAHITKVD 120 Query: 117 AEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILER 158 E + D +FP+ + +W+ + + F E+ Sbjct: 121 FEYDADAYFPNLDEKPEWQIT--GDSEEQTYFDLEFYFLRYEK 161 >UniRef50_A5WHY1 Dihydrofolate reductase n=4 Tax=Moraxellaceae RepID=A5WHY1_PSYWF Length = 193 Score = 162 bits (410), Expect = 4e-39, Method: Composition-based stats. Identities = 56/179 (31%), Positives = 88/179 (49%), Gaps = 28/179 (15%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTL-----------NKPVIMGRHTWESIG-R 52 I A++ +R IG N +PW++P DL FK T VIMGR T+ES+G + Sbjct: 11 IVAISRNRCIGKGNDLPWHIPNDLKHFKAMTTAETDAYVDTGLKGIVIMGRKTFESMGSK 70 Query: 53 PLPGRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDV------PEIMVIGGGR 98 PLP R N I+++Q V V ++D+A+ +V I VIGG R Sbjct: 71 PLPKRVNFIVTTQMDYAQQKGLEGLKDVHVVHNLDDALTHAANVAHGLKFETIWVIGGER 130 Query: 99 VYEQFLPKAQKLYLTHIDAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 V+++ + ++ LT +D ++E GD +P+ P+D+E D ++ SY F Sbjct: 131 VFKRAMMFTDRIELTVVDTDIEDGDAFYPEI-PEDFELTQESESFTDEKSGLSYKFMTY 188 >UniRef50_Q494F1 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia pennsylvanicus str. BPEN RepID=Q494F1_BLOPB Length = 164 Score = 161 bits (408), Expect = 6e-39, Method: Composition-based stats. Identities = 76/162 (46%), Positives = 106/162 (65%), Gaps = 4/162 (2%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 +ISLIAAL + +IG +N +PW LP D+ WFK +TL KP+IMGR T+ESIG +PL R N Sbjct: 2 IISLIAALTTNHIIGKKNVIPWYLPIDIKWFKYHTLYKPIIMGRKTFESIGKKPLLNRLN 61 Query: 60 IILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA- 117 I+LS + V +++DEA++ D E+MVIGG +Y FLP+AQ+LYLT+I Sbjct: 62 IVLSRNLLNNYNGVFIAENIDEALSLIQDAYEVMVIGGSEIYNVFLPRAQRLYLTYIHNM 121 Query: 118 -EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E++GD FPDY+ +W+S+F+ F+ F ILER Sbjct: 122 VEIDGDILFPDYDIREWKSIFNSFYKVREDCFCYLHFSILER 163 >UniRef50_C4WVU0 ACYPI002804 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WVU0_ACYPI Length = 184 Score = 161 bits (408), Expect = 7e-39, Method: Composition-based stats. Identities = 51/177 (28%), Positives = 87/177 (49%), Gaps = 19/177 (10%) Query: 1 MI-SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG- 51 M+ S+IAA++ + IG + +PW + ++ +F T VIMGR TW+SI Sbjct: 7 MVYSVIAAVSKNGGIGYKGNLPWKIKKEMEYFNLMTTRVNLKGVQNAVIMGRCTWQSIPD 66 Query: 52 --RPLPGRKNIILSSQPGT-DDRVTWVKSVDEAIAAC---GDVPEIMVIGGGRVYEQFLP 105 RPL GR N+++S + + V ++EA+ + + + VIGG +Y++ + Sbjct: 67 KYRPLKGRINVVISKTLNSVPEGVLLYPKLEEALKSLYLNDRIENLWVIGGSGLYKEAVN 126 Query: 106 --KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158 +KL++T ID E DT FPD++ +E N Y F++ +R Sbjct: 127 DKNCKKLFITKIDQEYLCDTFFPDFDTKKFEETSEANVPKGIQEDNGIKYEFKVFKR 183 >UniRef50_UPI000006EBF1 PREDICTED: hypothetical protein XP_002346735 n=1 Tax=Homo sapiens RepID=UPI000006EBF1 Length = 262 Score = 161 bits (407), Expect = 9e-39, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%) Query: 2 ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51 ++ I A++ + IG +PW L + +F+R T VIMG+ TW SI Sbjct: 80 LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 139 Query: 52 -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102 RPL GR N++LS + + +S+D+A+ V + ++GG VY++ Sbjct: 140 NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 199 Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFH---DADAQNSHSYCFEILE 157 + KL++T I + E DT FP+ + + ++ + D + Y FE+ E Sbjct: 200 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 259 Query: 158 R 158 + Sbjct: 260 K 260 >UniRef50_Q9CBW1 Dihydrofolate reductase n=25 Tax=Actinomycetales RepID=DYR_MYCLE Length = 165 Score = 161 bits (407), Expect = 9e-39, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 10/165 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 ++ LI A + VIG + MPW +P DL FK+ T+ PV+MGR TW+S+ RPLPGR Sbjct: 3 VVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGR 62 Query: 58 KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +NI+LS Q + S++E I+ PE+ VIGG ++Y LP A + +T +D Sbjct: 63 RNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVD 122 Query: 117 AEV---EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + + D P + D W V E+ + + Y R Sbjct: 123 TYLLHEDDDVLAPVLD-DTWVGVTGEWLVSCS--GLRYRLHSYHR 164 >UniRef50_Q2S5H3 Dihydrofolate reductase n=3 Tax=cellular organisms RepID=Q2S5H3_SALRD Length = 186 Score = 160 bits (406), Expect = 1e-38, Method: Composition-based stats. Identities = 66/168 (39%), Positives = 94/168 (55%), Gaps = 17/168 (10%) Query: 2 ISLIAALAV-DRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPG 56 + +IAA+A +RVIG + +PW++P DL FK+ T P++MGR T+ESI G PLP Sbjct: 21 LVIIAAVAEDNRVIGQDKDLPWHIPEDLKRFKQLTTGHPLLMGRRTFESIVHQFGGPLPD 80 Query: 57 RKNIILSSQPGTD--DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 RK ++L++Q + V SVD A+AA D + + GG VYEQFLP A +L LT Sbjct: 81 RKMVVLTTQDDYEAYPEVDTYASVDAALAALPDDATVFIGGGESVYEQFLPHADRLELTL 140 Query: 115 IDAEVEGDTHFPDYEP---DDWESVFSEFHDADAQNSHSYCFEILERR 159 ++ EGDT FP +E D +E + D + F ER+ Sbjct: 141 VEGAYEGDTFFPPFEHLIGDVFEETAVDARDG-------FRFVTYERK 181 >UniRef50_Q93341 Putative dihydrofolate reductase n=2 Tax=Caenorhabditis RepID=DYR_CAEEL Length = 189 Score = 159 bits (404), Expect = 2e-38, Method: Composition-based stats. Identities = 51/181 (28%), Positives = 76/181 (41%), Gaps = 25/181 (13%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 ++LI A+ + IG +PW + D+ +F T N V+MGR WESI Sbjct: 4 MNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNVSDQSKRNAVLMGRKCWESIPVTR 63 Query: 52 RPLPGRKNIILSSQP--GTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103 RPL GR NI+LS Q D V S++ A+ + + I IGG +Y+ Sbjct: 64 RPLAGRLNIVLSRQLPAQKSDDYIVVNSLEAAMKLLSEPPFVDSIETIWNIGGAEIYDLA 123 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWE-----SVFSEFHDADAQNSHSYCFEIL 156 L +++LT I E D H + E V SE + +N + F Sbjct: 124 LRENLVDEIHLTRIFKNFEADVHLKSLDFSKMEKVQNAEVSSENSEIFEENGLKFEFCKW 183 Query: 157 E 157 + Sbjct: 184 K 184 >UniRef50_B0VHY5 Dihydrofolate reductase n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHY5_9BACT Length = 141 Score = 159 bits (404), Expect = 2e-38, Method: Composition-based stats. Identities = 56/141 (39%), Positives = 80/141 (56%), Gaps = 4/141 (2%) Query: 20 MPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD-RVTWVKSV 78 MPW + DL FK T+ PVIMG++TW SIG+PLPGR+NI+LS S+ Sbjct: 1 MPWKITEDLKRFKAITMGHPVIMGKNTWNSIGKPLPGRQNIVLSKDRNFQPQGAIVAHSL 60 Query: 79 DEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFS 138 +EA+ E +IGG V++QFLP A K+ +T I +E EGDT+FP + +DW Sbjct: 61 EEALKMVEG-QEAYIIGGASVFKQFLPLADKMLITLIHSEFEGDTYFPYFSEEDWIL--Q 117 Query: 139 EFHDADAQNSHSYCFEILERR 159 E + + + C +I R+ Sbjct: 118 ESSSLLSSSGYELCLQIYIRK 138 >UniRef50_D2Q8R3 DfrA Dihydrofolate reductase n=12 Tax=Bifidobacterium RepID=D2Q8R3_9BIFI Length = 224 Score = 159 bits (403), Expect = 3e-38, Method: Composition-based stats. Identities = 62/182 (34%), Positives = 84/182 (46%), Gaps = 25/182 (13%) Query: 2 ISLIAALAVD-----RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRP 53 ++LI A A D IG E MPW LP D+ F T++ PVIMGR TWE++ RP Sbjct: 39 VNLIWAQARDKEGRDGAIGFEGGMPWRLPEDMKHFTELTVSHPVIMGRRTWEALSPKFRP 98 Query: 54 LPGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG---------DVPEIMVIGGGRVYEQF 103 LP R NI++S P T V ++D+A+ D EI +IGG +V+ Sbjct: 99 LPNRDNIVISHDPAYSAPGATVVDTLDDALDLARQEAIPDDGLDRSEIWIIGGAQVFRDA 158 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDY----EPDDWESVFSEFHDADAQNSHS---YCFEIL 156 LP A K Y+T I V+ DT+ PD E W + S + F Sbjct: 159 LPFADKAYVTQISMHVDADTYAPDIASLAESGAWRMAEEGVWQGTQKGSDDIAGFRFVTY 218 Query: 157 ER 158 E+ Sbjct: 219 EK 220 >UniRef50_C1C2C0 Dihydrofolate reductase n=1 Tax=Caligus clemensi RepID=C1C2C0_9MAXI Length = 178 Score = 159 bits (403), Expect = 3e-38, Method: Composition-based stats. Identities = 52/168 (30%), Positives = 86/168 (51%), Gaps = 14/168 (8%) Query: 2 ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKP-----VIMGRHTWESIG---R 52 I++IAA R IG +N +PW LP D+ +F+ T + VIMGR TWES+ R Sbjct: 9 INVIAAACKSSRGIGKDNDLPWKLPTDMKYFREKTASTTEIRVGVIMGRRTWESVPPKFR 68 Query: 53 PLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLP-KAQK 109 P R N++L+S+ + +++++A+ C +V I VIGG VY + L + Sbjct: 69 PFKNRFNVVLTSREDFEAKGAVIARTLEDAVKKCSNNVDSIWVIGGSGVYAEALNKYPCR 128 Query: 110 LYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 +YLT ID E + D FP + ++ +N ++ F++ + Sbjct: 129 VYLTEIDKEFDCDAFFPPLDEKKYKLAS--VSPDHQENDITFRFKVYD 174 >UniRef50_C9KQJ5 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase n=2 Tax=Veillonellaceae RepID=C9KQJ5_9FIRM Length = 342 Score = 159 bits (403), Expect = 3e-38, Method: Composition-based stats. Identities = 48/164 (29%), Positives = 72/164 (43%), Gaps = 17/164 (10%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 +S+IA + R IG + +LP D+ F+ T VIMGR T ES+ RPL R+N Sbjct: 168 LSMIACIDEGRGIGYRGELLVHLPEDMKHFRALTEGHVVIMGRRTMESLPGKRPLVNRQN 227 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFLPKAQKLYLT 113 I+LS Q + S+ + A ++ IGG +Y LP A ++ LT Sbjct: 228 IVLSRQLEGAEGFLICHSLPDLWRALGRLRAEKPQRKLWCIGGEELYRALLPYAHEVCLT 287 Query: 114 HIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 + A D FP + D+ V ++ + FE E Sbjct: 288 RLKAVYPADCFFPPLD--DFSLVDTDDREG-------LVFERYE 322 >UniRef50_Q59487 Dihydrofolate reductase n=17 Tax=Streptococcaceae RepID=DYR_LACLA Length = 168 Score = 159 bits (403), Expect = 3e-38, Method: Composition-based stats. Identities = 51/164 (31%), Positives = 89/164 (54%), Gaps = 6/164 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKN 59 MI I A +IG + MPW+LPA+ FK T+N+ ++MGR T+E + R LPGR + Sbjct: 1 MIIGIWAEDEAGLIGEADKMPWSLPAEQQHFKETTMNQVILMGRKTFEGMNKRVLPGRIS 60 Query: 60 IILSSQPGT---DDRVTWVKSVDEAIAAC-GDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 IIL+ +++V + S E + ++ + GG + F + + LY T + Sbjct: 61 IILTRDETYQSDNEKVLIMHSPKEVLDWYHKQNKDLFITGGAEILALFESELELLYRTVV 120 Query: 116 DAEVEGDTHFPD-YEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +GDT+FP ++ ++ V +FHD D +NS+++ + E+ Sbjct: 121 HEKFKGDTYFPSTFDFGRFKLVSEKFHDKDERNSYTFTIKKYEK 164 >UniRef50_Q13PE2 Dihydrofolate reductase n=1 Tax=Burkholderia xenovorans LB400 RepID=Q13PE2_BURXL Length = 171 Score = 159 bits (402), Expect = 4e-38, Method: Composition-based stats. Identities = 61/157 (38%), Positives = 84/157 (53%), Gaps = 7/157 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + L+AA+A +RVIG+ N +PW +P + F+ T+N+ V+MGR T+ESIG+PLPGR ++ Sbjct: 7 VVLVAAMAANRVIGLGNDIPWRIPGEQKRFRELTMNQLVVMGRRTFESIGKPLPGRDLLV 66 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LSS V VKS E AA + P I V GG +VY +P A +YLT ID Sbjct: 67 LSSGTSRLGTVRTVKSFAEVTAAVNNDPREAIFVGGGQQVYAMLMPYADVVYLTEIDLRP 126 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 GD FP+ P+ + S Y F Sbjct: 127 PGDAFFPEI-PERFSLPDSVDFP----GEIRYTFNTY 158 >UniRef50_B7C7C2 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C2_9FIRM Length = 159 Score = 158 bits (401), Expect = 4e-38, Method: Composition-based stats. Identities = 48/158 (30%), Positives = 83/158 (52%), Gaps = 5/158 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ++LIAA+ +R +G N M W+LP DL +F++ T ++MGR T+ES+ LP R +++ Sbjct: 3 LTLIAAIGKNRELGKNNDMIWHLPQDLKFFRQETSGHTIVMGRKTFESLPGKLPKRHHVV 62 Query: 62 LSSQ-PGTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +S + + +SV+E + D EI IGGG +Y + L A +L LT IDA+ Sbjct: 63 ISRTCKDLGEDIEMCESVEEFMKRYKDVDEEIYCIGGGMIYSEMLKYASRLVLTQIDADA 122 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 + + +FP+++ + + +N Y Sbjct: 123 DAEVYFPEFDESLYN---KKILSNIEENGVFYQHVEYT 157 >UniRef50_D2RRK6 Dihydrofolate reductase n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RRK6_9EURY Length = 181 Score = 157 bits (399), Expect = 7e-38, Method: Composition-based stats. Identities = 58/168 (34%), Positives = 83/168 (49%), Gaps = 20/168 (11%) Query: 5 IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI----GRPLPGRKNI 60 I A+A + VIG + MPW++PADL FK T++ P+IMGR T+E I G PLPGR + Sbjct: 19 IVAVADNGVIGKDGDMPWHIPADLKHFKETTMDHPIIMGRVTYEGILEALGEPLPGRTTV 78 Query: 61 ILS-SQPGTDDRVTWVKS--------VDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLY 111 +L+ T + +S A I V GG VYEQFL +L Sbjct: 79 VLTSRDLETPENAVTARSLEEALEAAETAARERHDAADRIFVAGGATVYEQFLSALDRLI 138 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +T + E +GDT+FPD++ ++ V + D + F RR Sbjct: 139 VTEVHEEPDGDTYFPDWDRASFDDVSRDDRDG-------FAFVEYVRR 179 >UniRef50_A1WYQ0 Dihydrofolate reductase n=1 Tax=Halorhodospira halophila SL1 RepID=A1WYQ0_HALHL Length = 164 Score = 157 bits (399), Expect = 9e-38, Method: Composition-based stats. Identities = 60/161 (37%), Positives = 80/161 (49%), Gaps = 8/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 I L+A + + VIG + PW+ DL FK T PVIMGR T +IGRPLP R NI+ Sbjct: 4 IVLVAIVGRNGVIGADGDQPWHFRCDLQRFKALTRGHPVIMGRRTLAAIGRPLPQRTNIV 63 Query: 62 LSSQPGTD-DRVTWVKSVD---EAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 L+ PG D V + A +M++GGG VY FLP+A +L LT +D Sbjct: 64 LTRDPGFHADGVEVATDPEAALARAAESAGGERVMILGGGDVYRLFLPRAHRLALTEVDD 123 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FP P +W+ E ++ + F L R Sbjct: 124 APPGDTTFPAIGP-EWQETAREE---AEEDGYRLTFRTLLR 160 >UniRef50_C0QWN0 Dihydrofolate reductase n=2 Tax=Brachyspira RepID=C0QWN0_BRAHW Length = 166 Score = 157 bits (398), Expect = 1e-37, Method: Composition-based stats. Identities = 56/167 (33%), Positives = 90/167 (53%), Gaps = 12/167 (7%) Query: 1 MISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRK 58 ++SLIAA+ IG+ MPW ++ D+ +F+ T VIMGR T+ES+G +PLP RK Sbjct: 2 IVSLIAAVDSKNGIGLNGVMPWGHIKEDMQFFRSTTTGYAVIMGRVTFESLGSKPLPNRK 61 Query: 59 NIILSSQPGTD-----DRVTWVKSVDEAIA--ACGDVPEIMVIGGGRVYEQFLPKAQKLY 111 NI++SS T+ D + + KS +++I+ +I +IGG +Y++ L A +Y Sbjct: 62 NIVISSNVNTELLNKYDNLFYEKSFEDSISKLLLEKNKQIFIIGGESIYKKALDYADMIY 121 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LTHID + D FP+ + + ++S + N S R Sbjct: 122 LTHIDKDYHCDRFFPEIDTNLFQSDELKTFFY---NDISVNIIKYTR 165 >UniRef50_P17719 Dihydrofolate reductase n=21 Tax=Endopterygota RepID=DYR_DROME Length = 182 Score = 157 bits (397), Expect = 1e-37, Method: Composition-based stats. Identities = 51/178 (28%), Positives = 85/178 (47%), Gaps = 22/178 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRN-------TLNKPVIMGRHTWESIG--- 51 +LI A+ + IG+ +PW + ++L +F R T V+MGR T+ + Sbjct: 4 FNLIVAVCENFGIGIRGDLPWRIKSELKYFSRTTKRTSDPTKQNAVVMGRKTYFGVPESK 63 Query: 52 RPLPGRKNIILSSQPGTDD---RVTWVKSVDEA---IAACGDVPEIMVIGGGRVYEQFL- 104 RPLP R NI+LS+ D V +++ A + +V I ++GG VYE+ + Sbjct: 64 RPLPDRLNIVLSTTLQESDLPKGVLLCPNLETAMKILEEQNEVENIWIVGGSGVYEEAMA 123 Query: 105 -PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESV---FSEFHDADAQNSHSYCFEILER 158 P+ +LY+T I + + DT FP PD + V +N + ++ILE+ Sbjct: 124 SPRCHRLYITKIMQKFDCDTFFPAI-PDSFREVAPDSDMPLGVQEENGIKFEYKILEK 180 >UniRef50_C7N8V9 Dihydrofolate reductase region n=5 Tax=Fusobacteriaceae RepID=C7N8V9_LEPBD Length = 173 Score = 157 bits (397), Expect = 1e-37, Method: Composition-based stats. Identities = 54/177 (30%), Positives = 93/177 (52%), Gaps = 26/177 (14%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M SLI A+ + IG N + W++P DL FK+ T+ K VIMG++T++SIG+PLP RKNI Sbjct: 1 MFSLIVAVGENNEIGKNNQLLWHIPEDLKNFKKITMGKTVIMGKNTYKSIGKPLPNRKNI 60 Query: 61 ILSSQPGTDDR---------------VTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQF- 103 +LS P + + ++ + I + EI +IGGG +Y++ Sbjct: 61 VLSRNPLEIEEKIKEDRKKYENENTKLELCDNLQKIIDKYKNSEEEIFIIGGGEIYKKAF 120 Query: 104 -LPKAQKLYLTHID-AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + +++Y++H++ ++ DT+FP + W + E +D + F I E+ Sbjct: 121 EMKIVKRIYMSHVNFSDKNADTYFPKIDLKKWVVITKENYDG-------WRFCIYEK 170 >UniRef50_B3RI81 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RI81_TRIAD Length = 174 Score = 157 bits (397), Expect = 1e-37, Method: Composition-based stats. Identities = 55/174 (31%), Positives = 84/174 (48%), Gaps = 24/174 (13%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG---RPLPGR 57 + DR IG +N +PW L + +F R T + V+MGR+TW SI RPL R Sbjct: 1 MTRDRGIGYKNDLPWKLRNEYKYFARLTTSTKDSAKKNAVLMGRNTWVSIPEKNRPLRNR 60 Query: 58 KNIILSSQ---PGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFL--PK 106 NI++SSQ + V V S+ E I V + ++GG VY+ F+ P+ Sbjct: 61 INIVISSQLRAEEVPEGVHVVASIPEVIELVQSPLLKDIVETVWIVGGAPVYKGFMSHPQ 120 Query: 107 AQKLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILER 158 ++YLT +DA E D FP+ DD++ + + +N Y F + +R Sbjct: 121 CDRIYLTKLDANYECDVFFPEM-SDDFKEISDPDVSQEVQEENGLKYTFHVYQR 173 >UniRef50_P00374 Dihydrofolate reductase n=50 Tax=root RepID=DYR_HUMAN Length = 187 Score = 157 bits (397), Expect = 1e-37, Method: Composition-based stats. Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 24/181 (13%) Query: 2 ISLIAALAVDRVIGMENAMPWN-LPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51 ++ I A++ + IG +PW L + +F+R T VIMG+ TW SI Sbjct: 5 LNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEK 64 Query: 52 -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102 RPL GR N++LS + + +S+D+A+ V + ++GG VY++ Sbjct: 65 NRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKE 124 Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFH---DADAQNSHSYCFEILE 157 + KL++T I + E DT FP+ + + ++ + D + Y FE+ E Sbjct: 125 AMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYE 184 Query: 158 R 158 + Sbjct: 185 K 185 >UniRef50_UPI00015B4DEB PREDICTED: similar to conserved hypothetical protein n=1 Tax=Nasonia vitripennis RepID=UPI00015B4DEB Length = 184 Score = 156 bits (395), Expect = 2e-37, Method: Composition-based stats. Identities = 51/179 (28%), Positives = 84/179 (46%), Gaps = 22/179 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT-------LNKPVIMGRHTWESIG--- 51 + LIAA + IG+ +PW L ++ +F + T V+MGR TWESI Sbjct: 5 LKLIAAACENMGIGVNGDLPWRLRKEMDFFTKMTSTTKDENKKNVVLMGRRTWESIPKKF 64 Query: 52 RPLPGRKNIILSSQP-GTDDRVTWVKSVDEAIAAC------GDVPEIMVIGGGRVYEQFL 104 +PL R N++L+SQP + K++ EAI V ++ VIGG VY+ + Sbjct: 65 KPLSNRINMVLTSQPLDLGEDAIVCKNLPEAIEKISQSPLKDKVEQVWVIGGSLVYKTSM 124 Query: 105 PKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVF--SEFHDADAQNSHSYCFEILERR 159 +LYLT + + + D FP+ P+D+ V + + +E+ E++ Sbjct: 125 ESPNFYRLYLTRVKKDFKCDAFFPEI-PNDYILVKDPEVPEGIQEEKDIKFEYEVYEKK 182 >UniRef50_D1YEK5 Dihydrofolate reductase n=3 Tax=Propionibacterium acnes RepID=D1YEK5_PROAC Length = 156 Score = 156 bits (394), Expect = 3e-37, Method: Composition-based stats. Identities = 49/161 (30%), Positives = 74/161 (45%), Gaps = 11/161 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + IAA+A + VIG M W++ D FK T+ +I GR T+E IG+ LPGR++II Sbjct: 3 VVAIAAVADNGVIGSGQDMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGK-LPGRRHII 61 Query: 62 LSSQP-GTDDRVTWVKSVDEAIAACGDVPE--IMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 + P + + V S +A+ + E V GGG++Y +L +T + Sbjct: 62 CTRDPHWSHEGVDVATSPRQAVEMAREAGEEICFVAGGGQIYADTFELCDELDITEVHQN 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 G FP +P+ W V E D + F RR Sbjct: 122 PNGAARFPAIDPEVWVEVRRESRDG-------FDFVGYRRR 155 >UniRef50_C3PEY4 Dihydrofolate reductase n=9 Tax=Corynebacterium RepID=C3PEY4_CORA7 Length = 181 Score = 156 bits (394), Expect = 3e-37, Method: Composition-based stats. Identities = 53/180 (29%), Positives = 79/180 (43%), Gaps = 23/180 (12%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI---GRPLPGR 57 M+ I A ++D VIG MPW++P DL FK T+ PVIMGR TWES+ RPLPGR Sbjct: 1 MLGAIWAQSLDGVIGDGVVMPWHVPEDLKHFKEVTMGAPVIMGRKTWESLTPKFRPLPGR 60 Query: 58 KNIILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLT-- 113 NI+LS + T V ++D A+ + + +IGGG++Y L + + LT Sbjct: 61 DNIVLSRREPGEWSAGATVVDNLDAAL--HATLDDAWIIGGGQLYSSALDRVDTIELTLM 118 Query: 114 --HIDAEVEGDTHFPDYEPDDWESVFSEFHDADA------------QNSHSYCFEILERR 159 + D P+++ + Y F +R+ Sbjct: 119 GVQVGDAYGADAVLAPSVPEEFSLSADSDWLTSESGHLTIPGQPPSELPMKYRFLTYDRK 178 >UniRef50_C7REN4 Dihydrofolate reductase region n=2 Tax=Anaerococcus RepID=C7REN4_ANAPD Length = 164 Score = 155 bits (393), Expect = 3e-37, Method: Composition-based stats. Identities = 45/161 (27%), Positives = 76/161 (47%), Gaps = 5/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +I A+ + IG + M +++ DL FK TL IMGR T+ES+G L R+NI+ Sbjct: 1 MKIILAVDKNWGIGKDGQMLFHIRRDLKHFKSYTLGNICIMGRKTYESMGGALTHRENIV 60 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + ++ + E+ VIGG ++ E FL + +T I + Sbjct: 61 LSRNKDYKAKDAKVFTDYRDVLSYVRERSEEVFVIGGEKIVEIFLEYCDEAIITKIYEKK 120 Query: 120 EGDTHFPDYE-PDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D+ +++ DDW SE D +N S+ + R+ Sbjct: 121 DADSFLHNFDQDDDWSL--SEESDIMEENGVSFRYVRYRRK 159 >UniRef50_C7XU42 Dihydrofolate reductase n=1 Tax=Lactobacillus coleohominis 101-4-CHN RepID=C7XU42_9LACO Length = 166 Score = 155 bits (393), Expect = 4e-37, Method: Composition-based stats. Identities = 46/159 (28%), Positives = 72/159 (45%), Gaps = 4/159 (2%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS + A IG +PW+LP DL FK T + P++MG T+ SIGRPLP R NI+ Sbjct: 3 ISFVWAEDEAGWIGKNGQLPWHLPVDLKHFKTVTDHHPIVMGARTFASIGRPLPNRPNIV 62 Query: 62 LSSQPGTDDRVTWVKSVDEAIAA----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +S P D+V V ++++ + D E+ +IGG ++ Q + L+ T + Sbjct: 63 VSHHPVAVDQVITVTNIEDLMNLIFKRYADQEEVCIIGGAGLFAQMVAHVNCLHRTIVMG 122 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 GD + W+ + + FE Sbjct: 123 NHHGDVKMIPIDYHQWQLTKKTPVYNSKTGALNCYFEEW 161 >UniRef50_Q0G0R9 Dihydrofolate reductase n=2 Tax=Aurantimonadaceae RepID=Q0G0R9_9RHIZ Length = 178 Score = 155 bits (393), Expect = 4e-37, Method: Composition-based stats. Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 7/165 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + A A + VIG + MPW++P+DL ++ T+ KP+IMGR T E+IG+ L GR +I+ Sbjct: 8 FVAVVAAAKNGVIGADGGMPWSIPSDLKRYRSLTMGKPMIMGRKTLEAIGKALDGRDSIV 67 Query: 62 LSSQPGTD-DRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 L+ + D EAIA EI V+GG +Y ++ LT Sbjct: 68 LTRENRLAVDGAMLASGPAEAIAKAIECASARRASEIAVVGGAEIYRLLWDHIDRIALTE 127 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +DAE EGD FP + ++E + E ++S + F+ +RR Sbjct: 128 VDAEPEGDAVFPAIDESEFELLSEEPWIRGERDSAATRFKSYQRR 172 >UniRef50_B9DU71 Dihydrofolate reductase n=13 Tax=Streptococcus RepID=B9DU71_STRU0 Length = 165 Score = 155 bits (393), Expect = 4e-37, Method: Composition-based stats. Identities = 48/161 (29%), Positives = 80/161 (49%), Gaps = 3/161 (1%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 I I A + VIG +PW LP +L FK TLN ++MGR T+E + R LP R+ + Sbjct: 5 IIAIWAEDENGVIGANGTLPWYLPKELQHFKNTTLNHAILMGRVTFEGMKRRLLPNRQTL 64 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +L+S D + S+++ + + VIGG +V + F K+ T + + Sbjct: 65 VLTSDESYHVDGALTMTSLEKTLEWYHAQENNLYVIGGQKVLQTFDGHFNKIIKTVVHHQ 124 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +GDT+ P+ + + F++ D QN + + IL R+ Sbjct: 125 FDGDTYRPELDLSPFVEEDCFFYERDDQNPYDFTVHILVRK 165 >UniRef50_C8WAC3 Dihydrofolate reductase region n=5 Tax=Coriobacteriaceae RepID=C8WAC3_ATOPD Length = 162 Score = 155 bits (393), Expect = 4e-37, Method: Composition-based stats. Identities = 46/161 (28%), Positives = 77/161 (47%), Gaps = 6/161 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKNI 60 ++ I ++ D IG + + AD+ +F +T + VIMGR T ES PL GR+NI Sbjct: 1 MNAIVSVTRDWGIGCDGDLLIPNKADMKYFVEHTRSCTVIMGRKTLESFPGGPLKGRRNI 60 Query: 61 ILSSQPGTD-DRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++S + V V S +EA+ D ++ +IGG +Y L + Y+T D Sbjct: 61 VISRNTNYQVEGVEIVSSAEEALRLVKDEAPEKVWLIGGASIYRALLDRCSYAYVTKHDT 120 Query: 118 EVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILE 157 V+ DT+FP+ + D W+ E + ++ F + Sbjct: 121 VVDADTYFPNLDEDPAWKVCNEEDGGVTPE-GVAFKFVTYQ 160 >UniRef50_B9YFM0 Dihydrofolate reductase region n=3 Tax=Nostocaceae RepID=B9YFM0_ANAAZ Length = 166 Score = 154 bits (390), Expect = 8e-37, Method: Composition-based stats. Identities = 53/167 (31%), Positives = 89/167 (53%), Gaps = 13/167 (7%) Query: 1 MISLIAALAVDRVIGMEN------AMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPL 54 +ISLIAA++ +R++ +PW++P+DL F++ T PVI+GR ++ + PL Sbjct: 3 LISLIAAISENRILADSKKEHIRVGIPWDIPSDLQHFQKKTWRHPVILGRKSYAAFNHPL 62 Query: 55 PGRKNIILSSQPGT-DDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLY 111 P R NIIL+ S+ EA+ + EI + GGG ++ + + A KLY Sbjct: 63 PNRTNIILTRSHDYKAPGCLVFYSLSEAVTWAKMSEKEEIFIAGGGEIFAEAIKFANKLY 122 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LT ++ EGD +FP++ ++ +V E H +N + F +ER Sbjct: 123 LTIVEGNFEGDVYFPEF--TNFGTVTKEEH--SQENDFQFKFVEIER 165 >UniRef50_C4QMV9 Dihydrofolate reductase n=1 Tax=Schistosoma mansoni RepID=C4QMV9_SCHMA Length = 186 Score = 154 bits (390), Expect = 8e-37, Method: Composition-based stats. Identities = 53/177 (29%), Positives = 88/177 (49%), Gaps = 21/177 (11%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG---R 52 ++++ A++ + IG +PW + D+ +FK T V+MGR TWESI + Sbjct: 3 LNVVVAVSENWGIGKGGGLPWKIKKDMEFFKTVTTKAHPGLKNAVVMGRVTWESIPESFK 62 Query: 53 PLPGRKNIILSSQPGTDDR-VTWVKSVDEAIAACGDVP------EIMVIGGGRVYEQFLP 105 PL R NI++SS V V S++ AI + E+ +IGG R+Y++ L Sbjct: 63 PLKDRINIVVSSTLSHAPSFVQVVPSLNAAIDLLYNEEFSSIVDEVFIIGGYRLYKEALK 122 Query: 106 ---KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILE 157 ++Y THI +EV+ DT+FP + D + V AD +N ++ F + + Sbjct: 123 QSIYPVRIYCTHILSEVDCDTYFPKVDWDKLKKVDLPDIPADTFTENGFTFKFCVYD 179 >UniRef50_C2CJZ1 Possible dihydrofolate reductase n=3 Tax=Anaerococcus RepID=C2CJZ1_9FIRM Length = 162 Score = 154 bits (389), Expect = 1e-36, Method: Composition-based stats. Identities = 47/160 (29%), Positives = 74/160 (46%), Gaps = 5/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +I A+ + IG M +++ DL FK T IMGR T+ES+G LP R+N+I Sbjct: 1 MKIILAVDKNWGIGKNGKMLFHIKKDLGHFKELTSGNICIMGRKTYESMGGALPNRENLI 60 Query: 62 LSSQPGT-DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 LS + + D E+ VIGG ++ E FL + +T I AE Sbjct: 61 LSRNKTYQAPDALVFNDYRDIFSYLEDKDKEVFVIGGEKIVELFLDFCDEAIITKIYAER 120 Query: 120 EGDTHFPDYEPDD-WESVFSEFHDADAQNSHSYCFEILER 158 D+ +++ DD WE + D +N S+ + + R Sbjct: 121 LADSFLHNFDSDDRWEVISK--SDIMEENGVSFQYIVYRR 158 >UniRef50_C0EGY7 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum DSM 5476 RepID=C0EGY7_9CLOT Length = 319 Score = 153 bits (388), Expect = 2e-36, Method: Composition-based stats. Identities = 55/168 (32%), Positives = 85/168 (50%), Gaps = 12/168 (7%) Query: 1 MISL--IAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPG 56 MI + I A+ IG EN + +++P D+A+F++ TLNK V+MGRHT ES+ RPL Sbjct: 1 MIKMKCIVAVDQAWGIGCENGLLYSIPEDMAFFRKTTLNKAVVMGRHTLESLPKSRPLKN 60 Query: 57 RKNIILSSQPGTD-DRVTWVKSVDE---AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYL 112 R NI++S S+ + A++ C D ++ V+GG VY L + + Sbjct: 61 RLNIVMSRDRSLQIGGAITCCSLQDLGVALSIC-DSDDVYVMGGYAVYSLLLDFCGQALI 119 Query: 113 THIDAEVEGDTHFPDYEPD-DWESVFSEFHDADAQNSHSYCFEILERR 159 T I + E D FP+ + D +W SE D + N Y F + + Sbjct: 120 TKIQGQREADRFFPNIDRDNNWTL--SEQSDVRSHNGLCYSFCVYANK 165 >UniRef50_UPI000186EC32 Dihydrofolate reductase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186EC32 Length = 190 Score = 153 bits (387), Expect = 2e-36, Method: Composition-based stats. Identities = 54/177 (30%), Positives = 80/177 (45%), Gaps = 20/177 (11%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIG--- 51 +LIAA+ + IG + +PWNL +L +F R T + VIMGR TW+S+ Sbjct: 5 FNLIAAVCSNNGIGYKGNLPWNLRKELQYFNRMTKDVKNPEKKNAVIMGRKTWDSLPHNW 64 Query: 52 RPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQFLP 105 +PLPGR N +L++Q D +++ I + VIGG +VYE L Sbjct: 65 KPLPGRYNFVLTTQSLNLDGAVVCSDLNDLIKKINSPDYSNLIETAWVIGGSKVYESVLK 124 Query: 106 K--AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158 + YLT I E E D F D++ V + +N Y F + E+ Sbjct: 125 YGLCHRFYLTRIKKEFECDCFFNYDFTKDFKEVSDDRVPKGVQKENEIEYVFHVYEK 181 >UniRef50_B4D395 Dihydrofolate reductase region n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D395_9BACT Length = 201 Score = 152 bits (385), Expect = 3e-36, Method: Composition-based stats. Identities = 57/189 (30%), Positives = 88/189 (46%), Gaps = 45/189 (23%) Query: 8 LAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQP- 66 ++++RVIG +N +PW+LP D WFK+ T V+MGR T+ES+GRPLP R NI+++ +P Sbjct: 1 MSLNRVIGRDNKIPWHLPEDFKWFKKLTTGHFVLMGRKTFESLGRPLPNRTNIVVTRKPL 60 Query: 67 ----------------------------------GTDDRVTWVKS---VDEAIAACGDVP 89 ++ V V+ + +A Sbjct: 61 RLARDPQFKATVGQARVGHWQARFGRPYQLGFERLSERDVWLVRDPRKLADAFEKARPSR 120 Query: 90 EIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSH 149 ++ VIGG ++YEQ LP+ LYL+ + EVEGD FP+ DDW + D Sbjct: 121 QLFVIGGAQIYEQLLPRCTDLYLSVVQREVEGDACFPEL-EDDWYLHDTPLRTPD----- 174 Query: 150 SYCFEILER 158 + + R Sbjct: 175 -FEVQHYRR 182 >UniRef50_C4V3M4 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase protein n=1 Tax=Selenomonas flueggei ATCC 43531 RepID=C4V3M4_9FIRM Length = 322 Score = 152 bits (385), Expect = 4e-36, Method: Composition-based stats. Identities = 47/164 (28%), Positives = 66/164 (40%), Gaps = 16/164 (9%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + LIAA+ IG + + P D+A F+R T+ V+MGR T ES+ RPL GR N Sbjct: 167 LELIAAVDDAGGIGRAGHLLTDCPEDMAHFRRMTMGGIVVMGRRTMESLPGRRPLVGRMN 226 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAA-----CGDVPEIMVIGGGRVYEQFLPKAQKLYLTH 114 I+LS D + + I VIGG Y LP + Y+T Sbjct: 227 IVLSRTMQETDGFYAAADILALWRLLGRLTAEEARPIFVIGGAACYRLLLPYVWRAYVTR 286 Query: 115 IDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + + D FP + + S FE+ ER Sbjct: 287 LLGSYDADVFFPSLD--GFSMTSSSAGQ-------DCIFEVYER 321 >UniRef50_C5BYZ5 Dihydrofolate reductase n=1 Tax=Beutenbergia cavernae DSM 12333 RepID=C5BYZ5_BEUC1 Length = 169 Score = 152 bits (384), Expect = 4e-36, Method: Composition-based stats. Identities = 53/169 (31%), Positives = 83/169 (49%), Gaps = 12/169 (7%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 MI +I A A D VIG +PW++P D A FK T V+MGR TW+S+ RP+P R Sbjct: 1 MIGMIWAQAHDGVIGARGTVPWHVPEDFAHFKATTRGHAVVMGRATWDSLPDRYRPMPER 60 Query: 58 KNIILSSQPGT-DDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 +N++++ Q D S+ +A+ C PE ++GG ++Y + +P A L +T +D Sbjct: 61 RNVVVTRQVDWSADGAERAGSIPDALERCAAEPETWIMGGAQIYAEAMPYADTLVVTQLD 120 Query: 117 --AEVEG--D-THFPDYEPDDWESVFSEFHDA--DAQNSHSYCFEILER 158 +VEG D H P P +W + ++ + R Sbjct: 121 LALDVEGAPDVVHAPPIGP-EWRIATDTWDGTWQTSRTGVRWQVHQYVR 168 >UniRef50_C8NZB9 Dihydrofolate reductase n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8NZB9_ERYRH Length = 150 Score = 152 bits (384), Expect = 5e-36, Method: Composition-based stats. Identities = 44/159 (27%), Positives = 81/159 (50%), Gaps = 11/159 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI +I A+ R IG+ +MPW+ DL F+++TLN+ V+MGR T+E + + L R+ Sbjct: 1 MIKIIVAMNNHRTIGLNGSMPWHNKEDLQHFRKSTLNQKVVMGRKTFEGLPKKLDNREIY 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAI-AACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 +++ ++ + + + +I + GGG +Y Q LP A +L +++I +V Sbjct: 61 VVTRNASIENAI---PDLRAFLMQHKESSEDIFIAGGGEIYAQSLPFAHELIISYIPNDV 117 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 GDT FPD+ +++ + ++ ER Sbjct: 118 IGDTFFPDFSDLEFKIKNQVEYS-------TFKQVTYER 149 >UniRef50_P78218 Dihydrofolate reductase type 15 n=153 Tax=root RepID=DYR15_ECOLX Length = 157 Score = 152 bits (384), Expect = 5e-36, Method: Composition-based stats. Identities = 51/160 (31%), Positives = 91/160 (56%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA++ + VIG +PW+ + FK T N+ +++GR T+ES+G LP RK + Sbjct: 3 LSLMAAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMG-ALPNRKYAV 61 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ T D+ V S+DEA+ + ++V GGG +Y+ + K L+++ ID E Sbjct: 62 VTRSSFTSSDENVLVFPSIDEALNHLKTITDHVIVSGGGEIYKSLIDKVDTLHISTIDIE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD +FP+ P + VFS+ ++ +Y ++I ++ Sbjct: 122 PEGDVYFPEI-PSSFRPVFSQDFVSN----INYSYQIWQK 156 >UniRef50_A3DES9 Dihydrofolate reductase n=5 Tax=Clostridium RepID=A3DES9_CLOTH Length = 167 Score = 151 bits (383), Expect = 5e-36, Method: Composition-based stats. Identities = 48/161 (29%), Positives = 76/161 (47%), Gaps = 8/161 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + I A+ + IG + + +P D+ +F++ TLNK V+MGR T+ES+ PL R N Sbjct: 1 MKAIVAVDSNWGIGYKGNLLQRIPEDMRFFRQMTLNKVVVMGRKTFESLPGKEPLKDRVN 60 Query: 60 IILSSQPGTD-DRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 IILS + D + +SVD + +I VIGG VY Q LP + ++T + Sbjct: 61 IILSKSENIEKDGIIICRSVDGLFLELKKYNSDDIFVIGGEEVYTQLLPYCSEAHVTKFN 120 Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEIL 156 D +FP+ + + W+ V + N Y Sbjct: 121 GAYSADRYFPNLDEMEGWKLVC--VGEPKEFNDIRYNRLKY 159 >UniRef50_D2SDU7 Dihydrofolate reductase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SDU7_9ACTO Length = 176 Score = 151 bits (383), Expect = 5e-36, Method: Composition-based stats. Identities = 59/163 (36%), Positives = 85/163 (52%), Gaps = 8/163 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 + L+ A A VIG + +PW+LP DL F+ T V+MGR TWES+ RPLPGR+ Sbjct: 3 VGLVWAQARGGVIGADGRLPWHLPEDLRLFRELTTGSTVVMGRRTWESLPERFRPLPGRR 62 Query: 59 NIILSSQ-PGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 N++L++ D V V++ +A D ++ VIGGGRVY FLP A ++ +T +D Sbjct: 63 NVVLTTDRSWAADGAERVDGVEDVLARTDDG-DLWVIGGGRVYAAFLPHADRVVVTDVDT 121 Query: 118 EVEGDTHFPDYEPDDWESVFSEF--HDADAQNSHSYCFEILER 158 +VEGDT P +W V + + Y R Sbjct: 122 DVEGDTWAPQLGA-EWARVSRTPASGWSASTTGLRYAVSGYTR 163 >UniRef50_Q934V0 Putative dihydrofolate reductase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934V0_SALTI Length = 158 Score = 151 bits (383), Expect = 6e-36, Method: Composition-based stats. Identities = 49/160 (30%), Positives = 82/160 (51%), Gaps = 6/160 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 + +IAA+ + IG+ N +PW P DL FK+ T N V+MGR T ES+ RPLP R N++ Sbjct: 1 MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV 60 Query: 62 LSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEG 121 L+ G + +D+ + + VIGGG++Y F+P ++++L+HI +V G Sbjct: 61 LTRSRGYIPNGFYPAGIDDVLRL---PDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVPG 117 Query: 122 -DTHFPD--YEPDDWESVFSEFHDADAQNSHSYCFEILER 158 D FP + V + + ++ + + R Sbjct: 118 ADAFFPAPMMRSLGFVPVETAYTQRANEDEPGFLQIVYRR 157 >UniRef50_Q4JX60 FolA protein n=3 Tax=Corynebacterium RepID=Q4JX60_CORJK Length = 234 Score = 151 bits (383), Expect = 6e-36, Method: Composition-based stats. Identities = 56/195 (28%), Positives = 83/195 (42%), Gaps = 39/195 (20%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGRK 58 I +I A D VIG MPW LP DL FK T PV+MGR +WE++ RPLP R Sbjct: 42 IGMIWAQTTDGVIGDGADMPWYLPEDLKHFKNATSGYPVVMGRTSWEALDDGFRPLPDRT 101 Query: 59 NIILSSQPGTD-DRVTWVKSVDEAIAACGDV-------------------PEIMVIGGGR 98 N +++ Q D S+ A+A + P + V+GGG+ Sbjct: 102 NYVITRQDNYDAPGGIVEPSIPSALANAAEQILNELTDSADKGEGADDRTPTVWVLGGGQ 161 Query: 99 VYEQFLPKAQKLYLTHIDAE----VEGDTHFPDYEPDDWESVFSEF----------HDAD 144 VY Q +P A ++ +T ID E + + P +++E ++ + D Sbjct: 162 VYAQCMPVADRIVITEIDMEAPERFQ--VYAPLVPEEEFEESAQDWQESEKGHPVDQEVD 219 Query: 145 AQNSHSYCFEILERR 159 + Y F RR Sbjct: 220 TEQPLRYRFCTWTRR 234 >UniRef50_UPI0001926A4C PREDICTED: similar to Dihydrofolate reductase CG14887-PB n=1 Tax=Hydra magnipapillata RepID=UPI0001926A4C Length = 189 Score = 151 bits (382), Expect = 7e-36, Method: Composition-based stats. Identities = 55/177 (31%), Positives = 84/177 (47%), Gaps = 22/177 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTL-------NKPVIMGRHTWESIG--- 51 + IAA+ + IG++ +PWNLP + +F+ T VIMG++TW SI Sbjct: 7 VHCIAAIDSEWGIGLKGKLPWNLPREYKFFQNITTKVISEGKQNAVIMGKNTWFSIPQQH 66 Query: 52 RPLPGRKNIILSSQ---PGTDDRVTWVKSVDEAIAACGDV------PEIMVIGGGRVYEQ 102 RPL R N+ILSS V S++ AI D I VIGG RVY++ Sbjct: 67 RPLKNRLNVILSSSFIKEDYPKNVLLESSLEAAILRLSDEFYANTVENIFVIGGSRVYKE 126 Query: 103 FLP-KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD--ADAQNSHSYCFEIL 156 + K+YLT I+ + D +P ++ + ++ + E D +N SY F + Sbjct: 127 AMEKFCDKIYLTKIEQDYSCDVFYPIFDTNKFKEIDDEEVDKNKQIENGVSYTFHVY 183 >UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE Length = 462 Score = 151 bits (381), Expect = 9e-36, Method: Composition-based stats. Identities = 44/162 (27%), Positives = 84/162 (51%), Gaps = 6/162 (3%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNI 60 S++ A+ ++ IG +N +PW L DL FK+ T VIMGR T+ES+ +PLP R N+ Sbjct: 7 FSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPLPNRVNV 66 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACG-DVPEIMVIGGGRVYEQFL--PKAQKLYLTHIDA 117 ++S + + V +++A+ ++ +IGG R++E+ L K ++LT I Sbjct: 67 VISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVHLTRIGV 126 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 E + D + ++ ++ ++N +Y ++ L + Sbjct: 127 ETKCDVYLNKNIFSTFQV--NKTSQTKSENGINYDYQHLINK 166 >UniRef50_A9HP20 Dihydrofolate reductase n=1 Tax=Roseobacter litoralis Och 149 RepID=A9HP20_9RHOB Length = 154 Score = 150 bits (380), Expect = 1e-35, Method: Composition-based stats. Identities = 50/157 (31%), Positives = 82/157 (52%), Gaps = 9/157 (5%) Query: 6 AALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKNIILSS 64 A A + IG + +PWN+P DL +F+R TL +IMGR+TWES+ +PLP R N+++SS Sbjct: 1 MARAENGAIGRDGTIPWNVPEDLKFFQRETLGGALIMGRNTWESLPVKPLPRRFNVVVSS 60 Query: 65 QPGTDDRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV-EG 121 T + SV AI I IGG +Y++ LP A +L ++ + +V + Sbjct: 61 NSDTAE--VVAPSVKVAIELAIEHGHQRIYGIGGAAIYQEMLPLAHRLLISEVQIDVPDA 118 Query: 122 DTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 DT FP+++ W+++ + + + R Sbjct: 119 DTFFPNFDVAGWKAIDTRPLRGQ---APACSVHEYLR 152 >UniRef50_Q8JKV3 Dihydrofolate reductase n=1 Tax=Heliothis zea virus 1 RepID=Q8JKV3_9VIRU Length = 264 Score = 150 bits (380), Expect = 1e-35, Method: Composition-based stats. Identities = 59/174 (33%), Positives = 87/174 (50%), Gaps = 18/174 (10%) Query: 2 ISLIAALAVDR-VIGMENAMPWNLPADLAWFKRNTL------NKPVIMGRHTWESIG--- 51 I+LI A+ + IGM NA+PW+L ++A F + T VIMGR TWESI Sbjct: 87 INLIVAVCENNMGIGMNNALPWHLKREMAHFTKTTTTATHPNKNAVIMGRLTWESIPKRF 146 Query: 52 RPLPGRKNIILSSQPGTD-DRVTWVKSVDEAIAACGDVPEI---MVIGGGRVYEQFL--P 105 RPLPGR NI+L+++ D D T V + DEAI +I VIGG VY + P Sbjct: 147 RPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRVVESRGDIETAWVIGGASVYAAAMTHP 206 Query: 106 KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 +++LT I E + FP + +E + + Y +++ ++R Sbjct: 207 NCHQIHLTAIKKYYECNVFFPKIDTTRFELISET--PCTREGDVQYSYKVYQQR 258 >UniRef50_P00381 Dihydrofolate reductase n=9 Tax=Lactobacillus RepID=DYR_LACCA Length = 163 Score = 149 bits (378), Expect = 2e-35, Method: Composition-based stats. Identities = 45/163 (27%), Positives = 81/163 (49%), Gaps = 5/163 (3%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M + + A D +IG + +PW+LP DL +F+ T+ K +++GR T+ES RPLP R N Sbjct: 1 MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN 60 Query: 60 IILSSQPGTDDRV---TWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHID 116 ++L+ Q + + A A E+++ GG +++ F L +T + Sbjct: 61 VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA 120 Query: 117 AEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 EGDT DD+ V S + D + ++ +E+ +++ Sbjct: 121 GSFEGDTKMIPLNWDDFTKVSSRTVE-DTNPALTHTYEVWQKK 162 >UniRef50_C5IWK1 Dihydrofolate reductase n=15 Tax=Bacteria RepID=C5IWK1_ECOLX Length = 157 Score = 149 bits (378), Expect = 2e-35, Method: Composition-based stats. Identities = 42/160 (26%), Positives = 84/160 (52%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 IS++AA++ + VIG +PW++ + FK T N +++GR T++S+G+ LP RK + Sbjct: 3 ISIMAAVSENGVIGSGLDIPWHVQGEQLLFKAMTYNHWLLVGRKTFDSMGK-LPNRKYAV 61 Query: 62 LSSQP--GTDDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ D V + S++ A++ + + V GGG +Y+ + +A ++L+ I Sbjct: 62 VTRSEMVSNDPDVIYFTSIESALSYLDNTTTHVFVSGGGEIYKALIEQADVIHLSVIHKH 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + GD FP P ++ F + ++ Y ++I + Sbjct: 122 ISGDVFFPSV-PQSFKQTFEQSFSSN----IDYTYQIWAK 156 >UniRef50_Q7VQK5 Dihydrofolate reductase type I n=1 Tax=Candidatus Blochmannia floridanus RepID=Q7VQK5_BLOFL Length = 168 Score = 148 bits (375), Expect = 5e-35, Method: Composition-based stats. Identities = 63/166 (37%), Positives = 95/166 (57%), Gaps = 8/166 (4%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 +ISLIAA ++ VIG +N +PW D+ WFK +T+ KPVIMGR T+ES+ +PLP R N Sbjct: 2 IISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRLN 61 Query: 60 IILSSQP----GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHI 115 I+LS + + +A++ E+M+IGGG VY F+ + ++YLT I Sbjct: 62 IVLSKHHILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRMYLTKI 121 Query: 116 DAEVE-GDTHFPDYEPDDWESVFSEFHDADAQNSHSY--CFEILER 158 D GD+ FP Y P++W V++ ++Y F+IL+R Sbjct: 122 DVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDR 167 >UniRef50_C5RC79 Dihydrofolate reductase n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5RC79_WEIPA Length = 168 Score = 148 bits (375), Expect = 5e-35, Method: Composition-based stats. Identities = 51/161 (31%), Positives = 83/161 (51%), Gaps = 4/161 (2%) Query: 3 SLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNII 61 +LI A +D I ++ +PW+ ADL +FK++T+++ +MGRHT S GRPLP R N++ Sbjct: 8 NLIWAQTLDGTIAIDGHIPWHQKADLQFFKQSTIHEAALMGRHTMASFHGRPLPERLNLV 67 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGDVP-EIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 L+ + V SV EA + ++ VIGG +YE F+ A LY+T++ + Sbjct: 68 LTRNHDLEVPEGFQKVYSVAEAEKVADNANLKLQVIGGKPIYESFMDTADTLYVTYLQTD 127 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 GD + W+ + ADA N + + R+ Sbjct: 128 FSGDVKMAPVDLTVWQGEVIDQGPADADNDYDWRLVKYTRQ 168 >UniRef50_B2GI60 Dihydrofolate reductase n=3 Tax=Actinomycetales RepID=B2GI60_KOCRD Length = 183 Score = 148 bits (375), Expect = 5e-35, Method: Composition-based stats. Identities = 59/181 (32%), Positives = 87/181 (48%), Gaps = 25/181 (13%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG---RPLPGR 57 M+ I A + D VIG++ +PW+L DL +F R T+ PVIMGR TWES RPLPGR Sbjct: 1 MVGAIWAQSPDGVIGVDGGIPWHLSEDLKFFARTTIGHPVIMGRRTWESFPEQFRPLPGR 60 Query: 58 KNIILSSQPGTD----DRVTWVKSVDEAIAAC------------GDVPEIMVIGGGRVYE 101 NI+++S+P + +RV V S EA+ E+ VIGG V+ Sbjct: 61 PNIVITSRPESVPADGERVWAVGSYAEALELAVSLLAAPGPEHEEPAREVWVIGGPGVWR 120 Query: 102 QFLPK----AQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILE 157 + + + +T +D +V GDTH P + W +A+N + + Sbjct: 121 EAVSHRPLPLTRALVTTVDLDVTGDTHAPALD-GSWSR-REVAGWTEARNGTWFRIDEWT 178 Query: 158 R 158 R Sbjct: 179 R 179 >UniRef50_P11731 Dihydrofolate reductase type 5 n=27 Tax=Bacteria RepID=DYR5_ECOLX Length = 157 Score = 147 bits (373), Expect = 8e-35, Method: Composition-based stats. Identities = 54/160 (33%), Positives = 90/160 (56%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA A + VIG +PW+ + FK T N+ +++GR T+ES+G LP RK + Sbjct: 3 VSLMAAKAKNGVIGCGPHIPWSAKGEQLLFKALTYNQWLLVGRKTFESMG-ALPNRKYAV 61 Query: 62 LSSQPGTD--DRVTWVKSVDEAIA-ACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 ++ T D V S++EA+ ++V GGG +Y + LP A L+++ ID E Sbjct: 62 VTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGGEIYRETLPMASTLHISTIDIE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGD FP+ P+ +E VF + ++ +YC++I ++ Sbjct: 122 PEGDVFFPNI-PNTFEVVFEQHFSSN----INYCYQIWQK 156 >UniRef50_C0VZ67 Possible dihydrofolate reductase n=3 Tax=Actinomycetaceae RepID=C0VZ67_9ACTO Length = 170 Score = 147 bits (373), Expect = 9e-35, Method: Composition-based stats. Identities = 52/169 (30%), Positives = 90/169 (53%), Gaps = 11/169 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR--PLPGRK 58 ++ +I A + +G + M W++PAD FK++T+ P+IMGR +W+++GR PLP R+ Sbjct: 3 VVKMIWAQDAEGKLGSGSEMLWHVPADFRHFKQSTVGFPLIMGRKSWDALGRFAPLPQRR 62 Query: 59 NIILSSQPGT-DDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHID 116 NI+++ + S++EAI+ E + + GG +YEQ +P A +L +T++D Sbjct: 63 NIVVTRNRDFIPEGGEVAFSIEEAISLASADSELVWIAGGAHIYEQAMPFADELVVTYLD 122 Query: 117 AEVEGD---THFPDYEPDDWESVFSEFHDADAQ---NSHSYCFEILERR 159 V + P +P WE V +E DAD + + + RR Sbjct: 123 LNVSTAGPVVYAPQIDPAVWEVVKAE-SDADWREKSGDARWKVVVYRRR 170 >UniRef50_C2D6N3 Possible dihydrofolate reductase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6N3_9ACTN Length = 186 Score = 147 bits (371), Expect = 1e-34, Method: Composition-based stats. Identities = 42/175 (24%), Positives = 73/175 (41%), Gaps = 19/175 (10%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGR-PLPGRKN 59 MI I ++ D IG + + AD+ F R T VIMG T+E+ + PL R+N Sbjct: 11 MIKAIVSVTQDWGIGYKGELLVPNKADMQHFVRMTTGACVIMGSTTFETFPKGPLKNRRN 70 Query: 60 IILSSQPGTD----------------DRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQF 103 I+L+ + S +A++ ++ +IGG Y+QF Sbjct: 71 IVLAQTHSYEREGFPKTTCTEQGTSVQNYEVYTSTQDALSHIKPDEDVWIIGGAYTYQQF 130 Query: 104 LPKAQKLYLTHIDAEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILE 157 LP ++ +T D + D +FP+ + DDW + ++ + F + Sbjct: 131 LPYCTEVVVTKNDCIRQADAYFPNLDKMDDWRITSTTEGGITSE-GVHFLFVTYQ 184 >UniRef50_Q86ZU9 Dihydrofolate reductase n=2 Tax=Agaricales RepID=Q86ZU9_COPCI Length = 205 Score = 147 bits (371), Expect = 1e-34, Method: Composition-based stats. Identities = 48/200 (24%), Positives = 76/200 (38%), Gaps = 43/200 (21%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNT------LNKPVIMGRHTWESIG---R 52 +++I A IG + +PW L ++ +F R T V+MGR TWESI R Sbjct: 4 LTIIVAATKANGIGKGSNLPWRLAKEMKYFARATSEAPEGTRNAVVMGRTTWESIPEKFR 63 Query: 53 PLPGRKNIILSSQPGTD--------DRVTWVKSVDEAIAACGDVP-----EIMVIGGGRV 99 PLP R N+++S + S+ + I VIGG + Sbjct: 64 PLPNRVNVVVSRNENYELEPGKEPSPMARLANSLSSGLRHLTTTDGLTVNRIFVIGGASL 123 Query: 100 YEQFL--------PKAQKLYLTHI-DAEVEGDTHFPDYEPD--DWESV----------FS 138 Y + L P ++ LT I + + + D P++ D +W FS Sbjct: 124 YRETLSLARSKTGPFVDRILLTRIVEPDFDCDVFMPEFNADGKEWTRSTHAELQEWVGFS 183 Query: 139 EFHDADAQNSHSYCFEILER 158 +N Y F++ R Sbjct: 184 VPEGIQEENGVKYEFQMWTR 203 >UniRef50_UPI000180BE95 PREDICTED: similar to GJ10259 n=1 Tax=Ciona intestinalis RepID=UPI000180BE95 Length = 194 Score = 147 bits (371), Expect = 1e-34, Method: Composition-based stats. Identities = 49/186 (26%), Positives = 83/186 (44%), Gaps = 29/186 (15%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN---------KPVIMGRHTWESIG- 51 I + A + IG + +PW LP ++ +FKR T VI+GR TWESI Sbjct: 8 IHSVVACCNNGGIGFKGRLPWRLPKEMKYFKRITTGEVEEFGGRRNVVIIGRKTWESIPK 67 Query: 52 --RPLPGRKNIILSS--QPGTDDRVTWVKSVDEAIAA------CGDVPEIMVIGGGRVYE 101 +PL R NI++S + V S+DE I C + ++ IGG +Y+ Sbjct: 68 SFKPLKDRINIVISRTLDKDCEGPDLVVNSLDELIDLLHSKPWCDKINQVFNIGGNEIYK 127 Query: 102 QFLP--KAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHD------ADAQNSHSYCF 153 K+YLT + A+++ DT + + D++ + +E +N + Sbjct: 128 LIHNSQYCGKIYLTRVLADLQCDTFLENLD-DNFTKLPTEGFPEVPQGIQMDKNDLQWKV 186 Query: 154 EILERR 159 E+ E++ Sbjct: 187 EVYEKK 192 >UniRef50_B7VPW7 Dihydrofolate reductase type I (Trimethoprim resistance) n=2 Tax=Vibrio splendidus RepID=B7VPW7_VIBSL Length = 183 Score = 146 bits (370), Expect = 2e-34, Method: Composition-based stats. Identities = 47/160 (29%), Positives = 86/160 (53%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +SL+AA+A + VIG +PW + + FK T N+ +++GR T+ES+G+ LP RK + Sbjct: 29 LSLMAAVAENGVIGSGLDIPWIVKGEQLLFKAMTFNQWLLLGRKTFESMGK-LPNRKYAV 87 Query: 62 LSSQPGT--DDRVTWVKSVDEAIAACGD-VPEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S P T D + + KSV++A+ V GGG++Y+ + + ++++ I Sbjct: 88 ISRSPSTSNDPDILYFKSVEDALGYLETVTEHAFVSGGGQIYKSLITQVDTIHISKIHKH 147 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + GD FP+ D VF + ++ Y ++I ++ Sbjct: 148 ISGDIFFPELPRDL-TLVFEQRFSSN----IDYTYQIWQK 182 >UniRef50_A4GI75 Dihydrofolate reductase n=1 Tax=uncultured marine bacterium HF10_29C11 RepID=A4GI75_9BACT Length = 168 Score = 146 bits (369), Expect = 3e-34, Method: Composition-based stats. Identities = 51/167 (30%), Positives = 79/167 (47%), Gaps = 10/167 (5%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNK---PVIMGRHTWESIG---RPL 54 M+ +I A+ +D IG EN +PW L +D+ FKR T+ + V+MGR TWE+I RPL Sbjct: 2 MLKMILAMDLDGCIGKENGLPWRLQSDMLRFKRLTIGQGNSAVLMGRTTWETIPERFRPL 61 Query: 55 PGRKNIILSSQPGTD-DRVTWVKSVDEAIAAC--GDVPEIMVIGGGRVYEQFLPKAQKLY 111 R NI+++ S++ I + E +IGG VYEQ +++ Sbjct: 62 VDRINIVVTRNRNYALSDAHVTYSIENGIEHASNNNCDECWIIGGADVYEQCRDLVDEIH 121 Query: 112 LTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 LT ++ GD + D+W E + N H + IL + Sbjct: 122 LTSVETSNSGDIKVGMFG-DEWNREIIESTPESSDNEHPTTYMILRK 167 >UniRef50_Q59397 Dihydrofolate reductase type 9 n=1 Tax=Escherichia coli RepID=DYR9_ECOLX Length = 177 Score = 146 bits (368), Expect = 3e-34, Method: Composition-based stats. Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 11/164 (6%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 +++I A+ IG EN +PW+ P DL FK T+N +IMGR T+ S+ + LPGR +++ Sbjct: 4 LNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRLHVV 63 Query: 62 LSSQ---PGTDDRVTWVKSVDEAIAACG------DVPEIMVIGGGRVYEQFLPKAQKLYL 112 +S D+V +V + A+ + +I VIGG YE KLYL Sbjct: 64 VSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDKLYL 123 Query: 113 THIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 T + + DT W+ V +N F+I Sbjct: 124 TRVQLNTQQDTELDLSLFKSWKLVSEV--PTITENKTKLIFQIW 165 >UniRef50_D1AYS8 Dihydrofolate reductase region n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AYS8_STRM9 Length = 156 Score = 146 bits (368), Expect = 3e-34, Method: Composition-based stats. Identities = 51/161 (31%), Positives = 93/161 (57%), Gaps = 10/161 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 MI ++ A+ + IG +N M W+ +L +F++ TLN ++MG++T+ SIGRPL R+NI Sbjct: 1 MIHIVVAVGENNEIGKDNKMLWHNSEELRFFRKLTLNHKIVMGKNTYLSIGRPLDLRENI 60 Query: 61 ILSSQPGTDDRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 ++S+ ++ + ++++D+ + D E I VIGG +Y+QFL +K+YL+ ID + Sbjct: 61 VISTTLEENEDIYVLRNIDKILEKYVDSDEIIYVIGGENIYKQFLKYTEKIYLSKIDGKF 120 Query: 120 -EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 159 + D +FP D+ + + N +++ I RR Sbjct: 121 PDADRYFPSINYDE--------YSTEVVNYNTFKLYIYTRR 153 >UniRef50_A8SSS6 Putative uncharacterized protein n=2 Tax=Bacteria RepID=A8SSS6_9FIRM Length = 168 Score = 145 bits (367), Expect = 4e-34, Method: Composition-based stats. Identities = 44/162 (27%), Positives = 69/162 (42%), Gaps = 8/162 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG--RPLPGRKN 59 + IAA+ + IG + ++ + D F++ T+ V++GR T E RPL GR N Sbjct: 1 MKFIAAVDNNWAIGNKGSLLVRISEDQKNFRKETMGHVVVLGRKTLEEFPGGRPLKGRTN 60 Query: 60 IILSSQPGT-DDRVTWVKSVDEAIAACGDVP--EIMVIGGGRVYEQFLPKAQKLYLTHID 116 IILS+ P V S+DE + +I +IGG VY+ +P +T ID Sbjct: 61 IILSTNPDYTVQDAVVVHSIDELFEKLSEYESDDIFIIGGQTVYDVLIPYCDTGIVTKID 120 Query: 117 AEVEGDTHFPDYEP-DDWESVFSEFHDADAQNSHSYCFEILE 157 E D + + D+W N + F + Sbjct: 121 KSYEADAFIQNLDEMDNWHVENERSG--TEPNDVNITFVTYK 160 >UniRef50_P27422 Dihydrofolate reductase type 7 n=46 Tax=Bacteria RepID=DYR7_ECOLX Length = 157 Score = 145 bits (367), Expect = 4e-34, Method: Composition-based stats. Identities = 48/160 (30%), Positives = 91/160 (56%), Gaps = 9/160 (5%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNII 61 ISLI+A + + VIG +PW+ + FK T N+ +++GR T++S+G LP RK + Sbjct: 3 ISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMG-VLPNRKYAV 61 Query: 62 LSSQ--PGTDDRVTWVKSVDEAIAACGDV-PEIMVIGGGRVYEQFLPKAQKLYLTHIDAE 118 +S + +++ V S++ A+ + + V GGG++Y + KA ++L+ + E Sbjct: 62 VSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHVE 121 Query: 119 VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 VEGD +FP P+++ VF +F ++ +Y ++I ++ Sbjct: 122 VEGDINFPKI-PENFNLVFEQFFLSN----INYTYQIWKK 156 >UniRef50_Q53D67 JM3 n=3 Tax=Macacine herpesvirus 5 RepID=Q53D67_9GAMA Length = 193 Score = 145 bits (366), Expect = 5e-34, Method: Composition-based stats. Identities = 50/181 (27%), Positives = 76/181 (41%), Gaps = 23/181 (12%) Query: 2 ISLIAALAVDRVIGMENAMPW-NLPADLAWFKRNTL-------NKPVIMGRHTWESIG-- 51 ++ I A+ IG MPW L ++ +F++ T VIMG+ TW SI Sbjct: 5 VNCIVAVDKQLGIGKNGTMPWPYLKNEMMYFQKMTSTPSVIGEKNVVIMGKRTWFSIPEK 64 Query: 52 -RPLPGRKNIILSSQPGTDDRVTWV--KSVDEAI------AACGDVPEIMVIGGGRVYEQ 102 RPL R NIILS + + +++D+A + + VIGG VYE Sbjct: 65 KRPLANRINIILSRELREPPKGAHFLARTLDDAFNFYRQYKLTKQLNTVWVIGGKSVYES 124 Query: 103 FLPKAQ--KLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDAD--AQNSHSYCFEILER 158 L KLY+T I + D FP ++ + +N Y F++ E+ Sbjct: 125 VLNYECSLKLYITRIMESFDCDVFFPSINFTEYTMLSELPGKDTNFEENGIKYKFQVYEK 184 Query: 159 R 159 R Sbjct: 185 R 185 >UniRef50_P15093 Dihydrofolate reductase n=3 Tax=Halobacteriaceae RepID=DYR_HALVO Length = 162 Score = 145 bits (366), Expect = 5e-34, Method: Composition-based stats. Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 12/159 (7%) Query: 5 IAALAVDRVIGMENAMPW-NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 +AALA +RVIG + +PW ++PAD ++ + PV++GR T+ES+ LPG I++S Sbjct: 6 VAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 Query: 64 S--QPGTDDRVTWVKSVDEAIAACG--DVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEV 119 + + D SV+EA+ D VIGG +Y F P ++ L+ + E Sbjct: 66 RSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEY 125 Query: 120 EGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 EGDT++P+++ +WE H+ + + R Sbjct: 126 EGDTYYPEWDAAEWELDAETDHEG-------FTLQEWVR 157 >UniRef50_Q4SM73 Chromosome 13 SCAF14555, whole genome shotgun sequence n=2 Tax=Tetraodon nigroviridis RepID=Q4SM73_TETNG Length = 198 Score = 144 bits (364), Expect = 8e-34, Method: Composition-based stats. Identities = 42/180 (23%), Positives = 76/180 (42%), Gaps = 23/180 (12%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLN-------KPVIMGRHTWESIGR-- 52 + LIAA IG +N MPW+LP++ +F +I G+ W S Sbjct: 11 VRLIAAKCNGGGIGKDNRMPWSLPSEFRFFLSTITRVSRPGKMNMIIWGKQCWISHPEST 70 Query: 53 -PLPGRKNIILSSQPGTDDR--VTWVKSVDEAIAACGD------VPEIMVIGGGRVYEQF 103 PLP + +LS+ +++D A+ + + + ++GG +VY++ Sbjct: 71 FPLPNVLHTVLSTTLFAVPDHAHFVCETLDAAVRLASEPPLADLIEIVWIVGGVQVYKEA 130 Query: 104 L--PKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVF---SEFHDADAQNSHSYCFEILER 158 + P +YLT I AE E D FP+++ ++ +N Y ++ +R Sbjct: 131 MEHPWCDLIYLTDIMAEFECDVFFPEFDRQLFQVQDGFPDVPDGIQEENGIKYKCQVYKR 190 >UniRef50_A8SNM7 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC 33270 RepID=A8SNM7_9FIRM Length = 166 Score = 144 bits (364), Expect = 8e-34, Method: Composition-based stats. Identities = 49/163 (30%), Positives = 82/163 (50%), Gaps = 9/163 (5%) Query: 2 ISLIAALAVD-RVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 + LI A+ IG +N + + L D+ +FK T + +I GR T+E +PLP RKN Sbjct: 6 LYLIVAITEKTNAIGKDNNLLYFLKEDMNFFKEKTCDNSIICGRKTFEGFKIKPLPKRKN 65 Query: 60 IILSSQPGTDDRVTWVKSVDEAIAACGDV--PEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 I+L+ + + V K++++ I + + V GG +YEQ + ++Y+T + Sbjct: 66 IVLTKSDFSFEGVRRFKNIEDLINFVKENPKEKFFVCGGMSIYEQLIDFCSRMYITKYEE 125 Query: 118 E--VEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 + VE D+HFP + W+ V E D ++N F ER Sbjct: 126 KEAVEADSHFPKIDEKVWKVV--EKIDGKSENP-KLTFYTYER 165 >UniRef50_C5VBQ6 Dihydrofolate reductase n=5 Tax=Corynebacterium RepID=C5VBQ6_9CORY Length = 160 Score = 144 bits (364), Expect = 8e-34, Method: Composition-based stats. Identities = 60/167 (35%), Positives = 84/167 (50%), Gaps = 20/167 (11%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIG-RPLPGRKN 59 M+ I A + +IG +MPW++P DL FK+ TL P+IMGR TWES+ RPLPGRKN Sbjct: 1 MLRAIWAQNLMGLIGDGKSMPWHVPEDLQHFKKLTLGSPIIMGRRTWESLPVRPLPGRKN 60 Query: 60 IILSSQP--GTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++LS + + + + SV E VIGGG VY + K Q+++ T IDA Sbjct: 61 LVLSRRTPGKWSNGASVIASVPE---------SGWVIGGGVVYAATIDKVQEIHRTLIDA 111 Query: 118 E---VE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E GD P PD ++ V + + Y FE + Sbjct: 112 PTNLFELGDRAVFAPTIPPD-FQLVQHSKWLKSS-SGLRYKFETWTK 156 >UniRef50_Q8EV82 Dihyrofolate reductase n=1 Tax=Mycoplasma penetrans RepID=Q8EV82_MYCPE Length = 154 Score = 144 bits (364), Expect = 1e-33, Method: Composition-based stats. Identities = 45/161 (27%), Positives = 79/161 (49%), Gaps = 11/161 (6%) Query: 1 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI 60 M I +R IG N +PWN+ DL FK++TLN ++MG++T+ SIG+ LP RKNI Sbjct: 1 MFISIWCEDKNRGIGKNNKLPWNIKEDLNLFKKHTLNNTIVMGKNTFLSIGKALPNRKNI 60 Query: 61 ILSSQPGTD--DRVTWVKSVDEAIAACGDVPE-IMVIGGGRVYEQFLPKAQKLYLTHIDA 117 ++S + +++ + E I +IGG +Y+ F+ K LY++ +++ Sbjct: 61 VISKTLDASLYKDIEVYDDIEQFYNEYKNRDESIFIIGGKSIYDYFINKCSILYVSKLNS 120 Query: 118 EVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 158 E D + D +E V + ++ + F + Sbjct: 121 AYECDLFMDN-SFDGFEIVNQKEYEQ-------FTFFEYRK 153 >UniRef50_UPI00017450E9 dihydrofolate reductase type III n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI00017450E9 Length = 179 Score = 144 bits (363), Expect = 1e-33, Method: Composition-based stats. Identities = 50/162 (30%), Positives = 82/162 (50%), Gaps = 7/162 (4%) Query: 2 ISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI-GRPLPGRKNI 60 ++LIAA+ + ++ +PW LP D+A F+ K +++GRHT+E + G P + + Sbjct: 8 LTLIAAVDENLLLATAQGIPWKLPDDVAHFRAYCAGKWLLLGRHTYEDMTGWFKPDQHPL 67 Query: 61 ILSSQPGTDDR-VTWVKSVDEAIAA--CGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDA 117 +L+S G + V SV +A+A E++ IGGG+V+ LP A +L +THI Sbjct: 68 VLTSTCGYEPNPGRGVASVPQALALAEAEGQEELVCIGGGQVFATALPHATRLVITHIKH 127 Query: 118 EVE-GD--THFPDYEPDDWESVFSEFHDADAQNSHSYCFEIL 156 E GD +FP D W H D +++ + F Sbjct: 128 IFEPGDQPVYFPPISADAWREERRLDHAVDDRHAWPFTFVEY 169 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.317 0.168 0.548 Lambda K H 0.267 0.0513 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,385,597,991 Number of Sequences: 3077464 Number of extensions: 73629653 Number of successful extensions: 146274 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 986 Number of HSP's successfully gapped in prelim test: 362 Number of HSP's that attempted gapping in prelim test: 142715 Number of HSP's gapped (non-prelim): 1414 length of query: 159 length of database: 1,040,396,356 effective HSP length: 118 effective length of query: 41 effective length of database: 677,255,604 effective search space: 27767479764 effective search space used: 27767479764 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 88 (38.2 bits)