BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (411 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria ... 857 0.0 UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14... 577 e-163 UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Ta... 434 e-120 UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria... 344 3e-93 UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydr... 324 3e-87 UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1... 259 2e-67 UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehyd... 252 2e-65 UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 ... 250 5e-65 UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-clust... 250 6e-65 UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Ta... 216 1e-54 UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydroge... 209 2e-52 UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genom... 206 2e-51 UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 ... 199 1e-49 UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax... 196 1e-48 UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 ... 185 2e-45 UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 ... 176 1e-42 UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine d... 158 3e-37 UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchae... 157 6e-37 UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 157 7e-37 UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+]... 147 5e-34 UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 145 3e-33 UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerot... 144 4e-33 UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 ... 142 2e-32 UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasm... 142 3e-32 UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10... 141 3e-32 UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerot... 141 4e-32 UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchae... 141 4e-32 UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocell... 140 9e-32 UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 ... 136 2e-30 UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 ... 134 7e-30 UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 ... 133 1e-29 UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga ... 128 5e-28 UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit ... 127 1e-27 UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 ... 124 8e-27 UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 ... 122 3e-26 UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotat... 121 4e-26 UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 120 6e-26 UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 ... 120 1e-25 UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 ... 119 3e-25 UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 ... 116 1e-24 UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9... 116 1e-24 UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfuroco... 115 2e-24 UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 115 2e-24 UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desul... 115 3e-24 UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured ... 113 1e-23 UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic... 110 1e-22 UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales... 110 1e-22 UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 ... 109 2e-22 UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subuni... 109 2e-22 UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 ... 108 4e-22 UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 ... 107 6e-22 UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria R... 107 8e-22 UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria R... 107 8e-22 UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomu... 106 1e-21 UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira... 106 2e-21 UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria ... 105 3e-21 UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerot... 105 3e-21 UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 103 1e-20 UniRef50_A9MK69 Putative uncharacterized protein n=1 Tax=Salmone... 102 3e-20 UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocys... 101 5e-20 UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 ... 101 6e-20 UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidal... 100 7e-20 UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteo... 100 8e-20 UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer s... 100 8e-20 UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit ... 99 2e-19 UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria R... 99 2e-19 UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10... 99 2e-19 UniRef50_UPI00019039D0 dihydropyrimidine dehydrogenase n=2 Tax=R... 99 3e-19 UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12... 97 9e-19 UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 97 9e-19 UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydoth... 97 1e-18 UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyru... 96 3e-18 UniRef50_A8RT96 Putative uncharacterized protein n=1 Tax=Clostri... 96 3e-18 UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 ... 95 4e-18 UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 92 3e-17 UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae Re... 92 5e-17 UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromat... 91 1e-16 UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family ... 90 1e-16 UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subuni... 89 3e-16 UniRef50_C4T7U5 Dihydropyrimidine dehydrogenase n=1 Tax=Yersinia... 89 4e-16 UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Cl... 88 5e-16 UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1... 87 8e-16 UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=St... 87 1e-15 UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglob... 86 2e-15 UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidob... 86 3e-15 UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 ... 86 3e-15 UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimona... 85 4e-15 UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 ... 84 9e-15 UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacte... 84 1e-14 UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 ... 84 1e-14 UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 83 2e-14 UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 ... 83 2e-14 UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycet... 80 1e-13 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 79 3e-13 UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collins... 79 5e-13 UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collins... 78 5e-13 UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular ... 78 7e-13 UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter... 75 4e-12 UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit ... 75 6e-12 UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobac... 74 9e-12 UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteo... 74 9e-12 UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella ... 74 1e-11 UniRef50_C2MA24 Dihydroorotate dehydrogenase 2 n=1 Tax=Porphyrom... 74 1e-11 UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 73 2e-11 UniRef50_D2S9D7 Dihydroorotate oxidase n=1 Tax=Geodermatophilus ... 73 2e-11 UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae... 72 4e-11 UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroi... 71 7e-11 UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidoba... 71 7e-11 UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 ... 70 1e-10 UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 ... 70 1e-10 UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibr... 70 2e-10 UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malasse... 69 4e-10 UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 ... 68 6e-10 UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebact... 68 6e-10 UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14... 68 7e-10 UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopol... 67 1e-09 UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family prote... 66 3e-09 UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_A... 65 6e-09 UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistip... 65 6e-09 UniRef50_Q56ZE6 Dihydroorotate dehydrogenase like protein (Fragm... 64 7e-09 UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular ... 64 8e-09 UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonprot... 64 9e-09 UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flav... 64 1e-08 UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobac... 64 1e-08 UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydrooro... 64 1e-08 UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=ca... 64 1e-08 UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 63 2e-08 UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacte... 63 2e-08 UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteri... 62 3e-08 UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotoga... 62 3e-08 UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family prote... 61 6e-08 UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 61 8e-08 UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 61 8e-08 UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobac... 61 9e-08 UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria R... 60 1e-07 UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 ... 60 1e-07 UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 60 1e-07 UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirell... 60 1e-07 UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae R... 60 2e-07 UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobac... 60 2e-07 UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago ma... 60 2e-07 UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospir... 60 2e-07 UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39... 59 3e-07 UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 ... 59 3e-07 UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular o... 59 3e-07 UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacte... 59 3e-07 UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacte... 59 3e-07 UniRef50_B3EQ67 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 59 3e-07 UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaprote... 59 4e-07 UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus... 59 4e-07 UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce... 58 6e-07 UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular or... 58 8e-07 UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio para... 57 1e-06 UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphyloco... 57 1e-06 UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria R... 57 1e-06 UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 57 1e-06 UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular o... 57 2e-06 UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacter... 57 2e-06 UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organ... 57 2e-06 UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. ... 57 2e-06 UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 56 3e-06 UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospiril... 56 3e-06 UniRef50_A1B7Q9 Dihydroorotate oxidase B, catalytic subunit n=1 ... 55 3e-06 UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=P... 55 4e-06 UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus te... 55 5e-06 UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 55 6e-06 UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria R... 54 8e-06 UniRef50_A7H8H3 Dihydroorotate dehydrogenase n=4 Tax=Anaeromyxob... 54 8e-06 UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter... 54 8e-06 UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanoba... 54 1e-05 UniRef50_Q8TY44 Ferredoxin n=1 Tax=Methanopyrus kandleri RepID=Q... 54 1e-05 UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota R... 54 1e-05 UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithioba... 54 1e-05 UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_L... 53 2e-05 UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular o... 53 2e-05 UniRef50_B3DVT8 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 53 2e-05 UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobact... 53 2e-05 UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 ... 52 3e-05 UniRef50_C1ZGV0 tRNA-dihydrouridine synthase n=1 Tax=Planctomyce... 52 4e-05 UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria ... 52 4e-05 UniRef50_A8L1Y0 Dihydroorotate oxidase n=4 Tax=Frankia RepID=A8L... 52 5e-05 UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococ... 52 5e-05 UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 51 7e-05 UniRef50_D2RDC3 Pyruvate ferredoxin/flavodoxin oxidoreductase, d... 51 8e-05 UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmid... 51 1e-04 UniRef50_A6UTY7 4Fe-4S ferredoxin iron-sulfur binding domain pro... 50 1e-04 UniRef50_B0TDY0 Iron-sulfur cluster-binding protein n=1 Tax=Heli... 50 1e-04 UniRef50_A6L8J9 Putative uncharacterized protein n=6 Tax=Bactero... 50 2e-04 UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyosteli... 50 2e-04 UniRef50_C0CVL1 Putative uncharacterized protein n=1 Tax=Clostri... 49 3e-04 UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepI... 49 3e-04 UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whippl... 49 3e-04 UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobaci... 49 4e-04 UniRef50_B3P4V6 GG16516 n=3 Tax=cellular organisms RepID=B3P4V6_... 49 4e-04 UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria R... 48 6e-04 UniRef50_Q2LR94 TRNA-dihydrouridine synthase n=2 Tax=Deltaproteo... 48 6e-04 UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, put... 48 7e-04 UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacter... 48 7e-04 UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neoricketts... 48 7e-04 UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/... 48 8e-04 UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Ric... 48 8e-04 UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, put... 48 8e-04 UniRef50_C0CNF3 Putative uncharacterized protein n=1 Tax=Blautia... 48 8e-04 UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=... 47 9e-04 UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobact... 47 0.001 UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsia... 47 0.001 UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria R... 47 0.001 UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira ... 47 0.001 UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=ca... 47 0.001 UniRef50_B8FE57 4Fe-4S ferredoxin iron-sulfur binding domain pro... 47 0.002 UniRef50_B7AS28 Putative uncharacterized protein n=1 Tax=Bactero... 47 0.002 UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae... 47 0.002 UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (c... 47 0.002 UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 47 0.002 UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaprote... 47 0.002 UniRef50_A6CFX5 Putative uncharacterized protein n=1 Tax=Plancto... 47 0.002 UniRef50_D1Y5W8 4Fe-4S ferredoxin, iron-sulfur binding domain pr... 46 0.002 UniRef50_UPI0001B4E622 dihydroorotate dehydrogenase n=1 Tax=Stre... 46 0.002 UniRef50_C1SIN0 Putative uncharacterized protein n=1 Tax=Denitro... 46 0.003 UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondr... 46 0.003 UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular o... 46 0.003 UniRef50_B8FAU6 Nitrite and sulphite reductase 4Fe-4S region n=1... 45 0.004 UniRef50_Q1AXJ2 2-oxoacid:acceptor oxidoreductase, delta subunit... 45 0.004 UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria Re... 45 0.005 UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=R... 45 0.005 UniRef50_C3WAR9 MinD family protein n=1 Tax=Fusobacterium mortif... 45 0.005 UniRef50_Q5JHV8 4Fe-4S cluster-binding protein n=1 Tax=Thermococ... 45 0.005 UniRef50_Q6SFW7 NifR3/Smm1 family protein n=1 Tax=uncultured mar... 45 0.006 UniRef50_B3QWF2 TIM-barrel protein, nifR3 family n=26 Tax=Bacter... 45 0.006 UniRef50_B0VJW9 Putative iron-sulfur cluster-binding protein n=1... 45 0.006 UniRef50_A0LJ96 Putative TIM-barrel protein, nifR3 family n=1 Ta... 45 0.006 UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromo... 45 0.007 UniRef50_D2C814 4Fe-4S ferredoxin iron-sulfur binding domain pro... 44 0.007 UniRef50_Q3A324 Dihydrouridine synthase n=10 Tax=Desulfuromonada... 44 0.009 UniRef50_C5EQJ3 NADH oxidase n=1 Tax=Clostridiales bacterium 1_7... 44 0.009 UniRef50_Q7X346 Putative uncharacterized protein n=1 Tax=uncultu... 44 0.009 UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 44 0.010 UniRef50_D1PSC3 4Fe-4S ferredoxin, iron-sulfur binding protein n... 44 0.010 UniRef50_B6W8L3 Putative uncharacterized protein n=1 Tax=Anaeroc... 44 0.010 UniRef50_A9KI98 4Fe-4S ferredoxin iron-sulfur binding domain pro... 44 0.011 UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistip... 44 0.012 UniRef50_Q12W37 4Fe-4S cluster-binding protein n=7 Tax=Methanosa... 44 0.012 UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus ce... 44 0.012 UniRef50_C0Q9H9 HdrA3' n=2 Tax=cellular organisms RepID=C0Q9H9_D... 44 0.014 UniRef50_A0LGM4 4Fe-4S ferredoxin, iron-sulfur binding domain pr... 44 0.014 UniRef50_A8TFX4 4Fe-4S ferredoxin iron-sulfur binding domain pro... 44 0.015 UniRef50_C8R1B2 4Fe-4S ferredoxin iron-sulfur binding domain pro... 44 0.015 UniRef50_A1S155 4Fe-4S ferredoxin, iron-sulfur binding domain pr... 44 0.016 UniRef50_C3X731 Molybdopterin oxidoreductase n=2 Tax=Oxalobacter... 44 0.016 UniRef50_C1EEA5 Dihydrouridine synthase n=1 Tax=Micromonas sp. R... 44 0.016 >UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria RepID=YEIA_ECOLI Length = 411 Score = 857 bits (2214), Expect = 0.0, Method: Compositional matrix adjust. Identities = 411/411 (100%), Positives = 411/411 (100%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR Sbjct: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA Sbjct: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG Sbjct: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR Sbjct: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL Sbjct: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ Sbjct: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL Sbjct: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 >UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14 Tax=Bacteria RepID=A5VL42_LACRD Length = 432 Score = 577 bits (1488), Expect = e-163, Method: Compositional matrix adjust. Identities = 268/413 (64%), Positives = 325/413 (78%), Gaps = 2/413 (0%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG--FFIANEVS 58 M+ KDLS+ F GV F NPFCLSSSPVGNCYEMC AYD GWGG+V+KT+ F +EVS Sbjct: 1 MIKKDLSVDFLGVHFENPFCLSSSPVGNCYEMCKNAYDAGWGGIVYKTLSPTHFKIDEVS 60 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 PRFD L KED F+ FKNMEQ++EHPLE++LA +RRLKE+YP+KVLIASIMGE + W Sbjct: 61 PRFDELAKEDMHFVAFKNMEQLSEHPLEQDLADMRRLKEEYPNKVLIASIMGETLEDWTN 120 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 LA+LV E GADMIE NFSCPQMTSH MGSDVG +PEL +K C AVKRG++LP+LAKMTPN Sbjct: 121 LAKLVTETGADMIELNFSCPQMTSHTMGSDVGTNPELCKKNCEAVKRGTSLPVLAKMTPN 180 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I M V A GGADG +AINTVKSI ++DL +K+G+P ++GKSS+SG SGKAVKPIA Sbjct: 181 ITTMVPVVKACLEGGADGFSAINTVKSIVDVDLKKKVGLPNIDGKSSVSGLSGKAVKPIA 240 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LRF+QQ+R+ L PISGIGGIETWEDAAEF+LLGA TLQVTT IM+YGYRI++D+ + Sbjct: 241 LRFLQQLRSAAGLEQLPISGIGGIETWEDAAEFILLGATTLQVTTAIMEYGYRIIDDLTN 300 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGG 358 GL HY+ +Q D LQ++VGLAN NI+P LDR+Y VYP+I+ DKC+GCGRC+ISC DG Sbjct: 301 GLMHYMEEQHVDHLQDLVGLANKNIIPTNQLDRNYKVYPKIDWDKCIGCGRCFISCQDGA 360 Query: 359 HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 HQA+ W ++ R P + KCVGC LC VCPVG I+LG V+ K G K +P + Sbjct: 361 HQALTWDDEKRQPVFDKSKCVGCQLCALVCPVGAIKLGLVEIKPGHKGNPAEI 413 >UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Tax=Bacteroides cellulosilyticus DSM 14838 RepID=UPI0001968A99 Length = 494 Score = 434 bits (1117), Expect = e-120, Method: Compositional matrix adjust. Identities = 208/392 (53%), Positives = 272/392 (69%), Gaps = 3/392 (0%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 +LS+ FCG++ NPF L+SSPV + +EMC A+D GW GV +KTI F+ + EVSPRFD L Sbjct: 101 ELSVNFCGIRCENPFFLASSPVASSFEMCCHAFDAGWAGVSYKTISFYQSREVSPRFDAL 160 Query: 65 VKEDT-GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 E F GFKN+EQ++ H EEN +RRLKE YP+KV+IASIMG N +W LAR+ Sbjct: 161 PGEHPFSFCGFKNLEQLSPHSAEENFEIIRRLKERYPEKVIIASIMGRNCDEWTVLARMA 220 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 +EAGAD+IECNFSCPQM +GSD+GQ +L+ Y RA ++GS LP++AKMTPNIG+M Sbjct: 221 EEAGADLIECNFSCPQMAKQGLGSDIGQDQDLIALYTRATRKGSRLPIIAKMTPNIGNME 280 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 A+ A GA+ +AAINTVKSIT I+ P + G+S++ GYSG+AVKPIALRFI+ Sbjct: 281 LPAMTAIANGANSLAAINTVKSITRINTENFSSYPDIGGQSAVGGYSGQAVKPIALRFIR 340 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + ++P L+ P+ GIGGI TW+DA +F+LLG LQV T +M+YGYRI++ + GLS Y Sbjct: 341 DLASYPPLKGIPLFGIGGITTWQDALDFILLGCTALQVCTSVMEYGYRIIDHLKEGLSIY 400 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 + SL E+ GLA N+V E LDR ++ I+ +C+ CGRCYISC DGGHQA+ Sbjct: 401 MKQHDIASLDELRGLALPNLVQPEQLDRERKLHCEIDSRRCIHCGRCYISCLDGGHQAIG 460 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 W + RTP + CVGC LC VCP I L Sbjct: 461 WEK--RTPMIDKSLCVGCGLCTLVCPTEAISL 490 >UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria RepID=A9GKC4_SORC5 Length = 462 Score = 344 bits (883), Expect = 3e-93, Method: Compositional matrix adjust. Identities = 183/432 (42%), Positives = 247/432 (57%), Gaps = 35/432 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLSI F G+K PNPF L+S+P N + +A+D GWGG V+KT+G I N VS RF + Sbjct: 3 DLSIDFAGIKSPNPFWLASAPPTNTGDQVRRAFDAGWGGAVWKTLGNPIVN-VSSRFGGI 61 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 +T +G N+E I + PL+ NL +R +K YP LIAS+M E + +W E+ R + Sbjct: 62 DYGNTRLMGLNNVELITDRPLDVNLKEMREIKRRYPGHALIASLMVETKDEWREIIRKAE 121 Query: 125 EAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + GAD +E NF CP M MGS VG P ++++ R +T P++ K+TPN+GD+ Sbjct: 122 DTGADGLELNFGCPHGMCERGMGSAVGNEPAVLQEIARWAVEFATTPVIVKLTPNVGDIL 181 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E A R GA G++ INTVKS+ +DL + + +P V G S+ GY G AVKPIAL + Sbjct: 182 EPGEAVLRSGAHGVSLINTVKSLMGVDLERMVPLPRVGGASTNGGYCGPAVKPIALHLLS 241 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q+ HP + PISGIGGI DAAEF+ LGA ++QV T +M YGYRIVE+M GLS + Sbjct: 242 QLARHPGVGRLPISGIGGISNSRDAAEFIALGATSVQVCTAVMHYGYRIVEEMIEGLSDW 301 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 L D G S+ E+ G A + +LD SY V I+ DKC+GC CY++C DG HQ + Sbjct: 302 LDDHGMRSVNELRGRAIPQVQEWGELDLSYRVVADISADKCIGCQLCYVACMDGAHQCIH 361 Query: 364 WSEKT--------------------------------RTPHCNTEKCVGCLLCGHVCPV- 390 +T R P + E+C+GC LC VCPV Sbjct: 362 LPGRTEAEARAAGHTHLPKVLPDRAVTADPSGDAAPSRVPFVDEEECIGCNLCALVCPVP 421 Query: 391 GCIELGEVKFKK 402 GCI + EV K Sbjct: 422 GCITMREVPSGK 433 >UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydrouracil dehydrogenase (NAD+) / dihydroorotate oxidase B, catalytic subunit n=94 Tax=Bacteria RepID=Q01P61_SOLUE Length = 446 Score = 324 bits (831), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 182/432 (42%), Positives = 255/432 (59%), Gaps = 39/432 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS F G++ PNPF L+S P NC E +A+D GWGG V+KTIG I N VS R+ + Sbjct: 3 DLSTNFAGIRCPNPFWLASGPPTNCGEQIMRAFDAGWGGAVWKTIGEPIVN-VSSRYSSV 61 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-WEELARLV 123 +G N+E I++ P+E NL + +K+ YP +IAS+M E+ ++ W ++ + Sbjct: 62 DWNGQRMMGLNNIELISDRPIETNLREITEVKKRYPKHAVIASLMVESTREAWHDIVKRS 121 Query: 124 QEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 ++AGAD +E NF CP M+ MG+ VGQ P+ VK + P+L K+TPNI D+ Sbjct: 122 EDAGADGLELNFGCPHGMSERGMGAAVGQVPDYSCMITEWVKEVARTPVLVKLTPNITDI 181 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 VA AAKRG AD ++AINT+ SIT IDL+ P V GK+S GY G AVKPIAL + Sbjct: 182 RAVARAAKRGRADALSAINTINSITGIDLDTFTPRPNVGGKTSHGGYCGPAVKPIALHLV 241 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 QQ+ + P + PISGIGGI W +AAEF+LLG T+QV T M YG+RIVEDM GLS+ Sbjct: 242 QQIASDPAV-GLPISGIGGIGGWREAAEFILLGCGTVQVCTAAMHYGFRIVEDMIDGLSN 300 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ-- 360 ++ ++GF ++++ GL+ + + LD +Y + RIN DKC+GC CY++C+DG HQ Sbjct: 301 WMDEKGFRTIEDFRGLSVPRVTDWKHLDLNYKIVARINRDKCIGCDLCYVACWDGAHQCI 360 Query: 361 ---------AMEWSEKT-----------------------RTPHCNTEKCVGCLLCGHVC 388 A+E + + R P + +CVGC LC VC Sbjct: 361 HLDGHAVPAAVEAASRASIAVTPIAKLDAAQAALGTTPPHRIPRVDEHECVGCNLCWLVC 420 Query: 389 PV-GCIELGEVK 399 PV CI + +V+ Sbjct: 421 PVEHCITMEKVE 432 >UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1EGR6_9CHLO Length = 434 Score = 259 bits (661), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 144/333 (43%), Positives = 204/333 (61%), Gaps = 9/333 (2%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF--IANEVSPRFD 62 DLS+T G+KFPNPF + S P G Y + KA+D GWGGV+ KT+ + V+PR+ Sbjct: 63 DLSVTVNGLKFPNPFVIGSGPPGTNYTVMKKAFDEGWGGVIAKTVSLNADLVKNVTPRYA 122 Query: 63 HLVKEDTG-FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQWEELA 120 + ED +G++N+E I++ E LA ++LKE+YPD++LIASIM E ++ W E+ Sbjct: 123 KMKSEDGAEVLGWQNIELISDRSFEVMLAEFKQLKEEYPDRILIASIMDEYKKENWVEVV 182 Query: 121 RLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 R +E G D E NFSCP M MG+ +GQ ++++ C VK +T+P+ AKMTPNI Sbjct: 183 RRCEEVGVDAFEINFSCPHGMPERKMGAAMGQDCTVLDEVCGWVKEVATVPVWAKMTPNI 242 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E A G DGIAAINT+ SI ++L+ P V G S+ GYS KAV+PIAL Sbjct: 243 TDITEPANVCLEKGMDGIAAINTIMSIMGVNLDTLAPEPCVEGHSTPGGYSYKAVRPIAL 302 Query: 240 R---FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 I QM E D +SGIGGI+T AAEF+LLG+ T+QV TG+M +GY +V+++ Sbjct: 303 AKCMAIAQM-IKKEFPDRTLSGIGGIDTGGHAAEFILLGSDTVQVCTGVMIHGYPLVQNL 361 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVPAEDL 329 + L ++ GF+S+ E G++ DL Sbjct: 362 CAELQEFMGKHGFESIAEFKGMSLEYFTTHTDL 394 >UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehydrogenase-like protein n=14 Tax=cellular organisms RepID=Q9LVI9_ARATH Length = 426 Score = 252 bits (643), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 138/325 (42%), Positives = 196/325 (60%), Gaps = 12/325 (3%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN--EVSPRFD 62 DLS+T G+K PNPF + S P G Y + +A+D GWG V+ KT+ + V+PR+ Sbjct: 51 DLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLDASKVINVTPRYA 110 Query: 63 HLVKEDTG-----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQW 116 L G IG++N+E I++ PLE L RLK++YPD++LIAS+M E N+ W Sbjct: 111 RLRTGSNGSAKTDVIGWQNIELISDRPLETMLKEFERLKKEYPDRILIASVMEEYNKTAW 170 Query: 117 EELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 EEL V++ G D +E NFSCP M MG+ VGQ L+++ C + +T+P+ AKM Sbjct: 171 EELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLDEVCGWINAKATVPVWAKM 230 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 TPNI D+ E A + + G +GIAAINT+ S+ ID+ P V G S+ GYS KAV+ Sbjct: 231 TPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDMKTLRPEPCVEGYSTPGGYSYKAVR 290 Query: 236 PIALR---FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 PIAL I +M D +SGIGG+ET DAAEF+LLG+ T+QV TG+M +GY Sbjct: 291 PIALAKVMNIAKMMKSEFSEDRSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMMHGYGH 350 Query: 293 VEDMASGLSHYLADQGFDSLQEMVG 317 V+ + + L ++ F +++E G Sbjct: 351 VKTLCAELKDFMKQHNFSTIEEFRG 375 >UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E2T4_GEOLS Length = 398 Score = 250 bits (639), Expect = 5e-65, Method: Compositional matrix adjust. Identities = 137/395 (34%), Positives = 215/395 (54%), Gaps = 11/395 (2%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L T+ GV F NPF L+S+P +M +A++ GWGG V KT+ + + RF + Sbjct: 5 LDSTYLGVVFRNPFVLASAPPTATADMVRRAFEAGWGGAVIKTLIREPVHNLPNRF-AAI 63 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG--ENEQQWEELARLV 123 + GF+N+E ++E +E A+R +K D+PD +I SIMG + +W LA Sbjct: 64 RHGNRITGFENLELLSEQAPDEWYRAIRCIKADFPDCPIIGSIMGAANSPDEWHSLALGC 123 Query: 124 QEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVK--RGSTLPMLAKMTPNIG 180 Q+AGAD++E NFSCP G+ +GQ+P+ + R V + T+P++ K+T + Sbjct: 124 QDAGADLLELNFSCPHGYPERGRGAAIGQNPDYAAQITRWVTDCKEITIPVIPKLTAAVA 183 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++ +A GA G AINT+ S DL P + GK+S GYSG +KPIALR Sbjct: 184 NIQNIAEELALAGAHGFCAINTIPSFFGFDLRTLRPKPDIGGKTSYGGYSGPGIKPIALR 243 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ P L P+ GGI DA EF+LLGA +Q+ T +M +G+ I++ M L Sbjct: 244 AVSELCQSPGL---PVMASGGIANGFDAVEFMLLGAPVVQMATEVMLHGFGIIDRMQQEL 300 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 ++ F + + +GL ++ + L +V PR+ ++C CG C+ +C DGG+Q Sbjct: 301 REFMTWHDFTAPVDFIGLCRDSATSFKKLPAGTMVSPRLLAERCTHCGACFTACRDGGYQ 360 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 A+ W++ P + C C LC HVCP G +++ Sbjct: 361 AISWNKG--LPGIDPTVCKSCSLCSHVCPAGALQM 393 >UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-cluster domain n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E020_METI4 Length = 387 Score = 250 bits (639), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 140/351 (39%), Positives = 211/351 (60%), Gaps = 13/351 (3%) Query: 57 VSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQ 115 VS R+ K D +G N+E I++ PL NL ++ +K +P++ LI S+M E + ++ Sbjct: 4 VSNRYAVYKKGDR-ILGMNNLELISDRPLSVNLKEIQEVKRLWPNRALIVSMMEEYDRKK 62 Query: 116 WEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 WEELA+ ++ +GAD IE NF CP M GS +GQ P + V+R ++LP++ K Sbjct: 63 WEELAQKIEGSGADGIELNFGCPHGMPERGTGSKIGQDPARCAEVTSWVRRVTSLPLIVK 122 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 +TPN+ D+ +A AA GGA ++ INT++SI +D++ +P + GKSS SGYSG+A+ Sbjct: 123 LTPNVTDISCIARAAIAGGASALSLINTLESILGVDIDTFEVLPSIAGKSSHSGYSGEAI 182 Query: 235 KPIALRFIQQMRTHPEL--RDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 KPIAL ++ + E+ + IS +GGI +W D EFLLLGA +LQ+ T +M G+RI Sbjct: 183 KPIALNLTAKVASMEEVQKKGLAISAMGGISSWRDGVEFLLLGATSLQLCTSVMLKGFRI 242 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYI 352 ED+ SGL +++ +GF S+ E G + +++VP LD + +IN KC+ C CY+ Sbjct: 243 AEDLLSGLKNWMRSKGFRSIAEFRGKSLSHLVPFSKLDPLFKEVAKINPQKCIRCLLCYV 302 Query: 353 SCYDGGHQAME-------WSEKTRTPHCNTEKCVGCLLCGHVCPV-GCIEL 395 C D +Q +E +S PH CVGC LC H+CPV CIE+ Sbjct: 303 GCRDSAYQCIEVDNKLDLFSNPVNYPHVREADCVGCSLCRHLCPVDSCIEM 353 >UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0EHW2_ENTDI Length = 901 Score = 216 bits (550), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 148/454 (32%), Positives = 233/454 (51%), Gaps = 65/454 (14%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 D+S+T G+K+ NPF +SS+PV Y+ + + G+G + KT + + ++ + +H+ Sbjct: 437 DISVTVDGIKYENPFGISSAPVSGTYDHLKRCFQAGFGFALTKT--YPLEKDIQ-KNNHI 493 Query: 65 ----VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM-GENEQQWEEL 119 V + + N+ I+EH L ++++LK ++P+KV+IASIM +N W L Sbjct: 494 RIVKVYDSQESTSYNNIVMISEHSHHYWLESIKKLKAEFPNKVVIASIMCMDNADDWHLL 553 Query: 120 ARLVQEAGADMIECNFSCPQ---------------MTSH-AMGSDVGQSPELVEKYCRAV 163 A+L +EAGAD +E NFSCP SH AM +G SP +E+ R V Sbjct: 554 AKLSEEAGADALELNFSCPNECHGNDGNEGGCEGGFKSHNAMAMAIGVSPAAIERCTRYV 613 Query: 164 KRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK 223 +P+ K+TPN+G++ E+A AA RGGA G++ INTV I+ I L+ + + Sbjct: 614 VESVHIPVYPKLTPNVGNIEELAAAAMRGGASGVSTINTVFGISEITLSGHPWPQVGVER 673 Query: 224 SSIS-GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 ++IS G SG V+PIA+R I Q+ H E + GIGG+ + E A + + GA+ +Q+ Sbjct: 674 NTISGGLSGDLVRPIAIRQIAQVLRHNENVRGHLLGIGGVRSAETAMQLIYTGASVVQMC 733 Query: 283 TGIMQYGYRIVEDMASG------------LSHYLADQGFDS------------------- 311 + + ++ Y IV+++ SG L YL QG +S Sbjct: 734 SSVQKWSYDIVDEIISGTKFILYCWSRPDLRGYLNSQGVESFMPYGEKTPFWTLDNKQDK 793 Query: 312 ----LQEMVGLANNNIVPAEDLD--RSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWS 365 L E+ G+A +I + L+ + V I + C+GCG C +SC D A+ Sbjct: 794 PVPKLAEVTGIALKHIGERKILEGPEKWRVNAHIK-NNCIGCGSCALSCRDNSTTAI--V 850 Query: 366 EKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 + + EKC+GC LC VCPV IE +VK Sbjct: 851 KDGNRYRVDDEKCIGCALCSSVCPVNAIEYVKVK 884 >UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydrogenase n=1 Tax=Sulfolobus tokodaii RepID=Q972L2_SULTO Length = 350 Score = 209 bits (531), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 126/349 (36%), Positives = 193/349 (55%), Gaps = 10/349 (2%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANE-VSPRFDH 63 DLS+TF G+ FPNPF + S P A GWGGVV KTIG I + V P + Sbjct: 3 DLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMY-A 61 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKV-LIASIMG-ENEQQWEELAR 121 ++ + I F+N+E I E PLE LR +K + +I SIMG + +W LAR Sbjct: 62 TIRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLAR 121 Query: 122 LVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ GADM+E NF CP G+ +GQ +LV++Y + V +P++AK+TPNI Sbjct: 122 WAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEYTKEVVSSVGIPVIAKLTPNIT 181 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ E A AA+ GA + AINTV + +D+ + +P +NG S G SG AVKPI L Sbjct: 182 DIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGLA 241 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ T L+ ISG+GGI W DA E++++GA T+Q T + G+ + + L Sbjct: 242 AVSKIYTSTSLQ---ISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKEL 298 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGR 349 ++ +G+ ++++M GLA + E L++ + R ++D+ + R Sbjct: 299 ESFMERKGYRAIEDMRGLAAKKMTTYEVLEK--VTKRRTSVDEEINTVR 345 >UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CDX9_PARTE Length = 997 Score = 206 bits (523), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 138/428 (32%), Positives = 214/428 (50%), Gaps = 53/428 (12%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANE-----VSP 59 DLSI GV F NPF L+S+P Y M +A+ GWG V KT F+ ++ VSP Sbjct: 544 DLSINILGVNFLNPFGLASAPPTTSYPMIKRAFQEGWGFAVVKT---FVLDKDAITNVSP 600 Query: 60 RF----DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN-EQ 114 R +K+D G+ N+E I+E + L + +K+++P+ VLI SIM ++ EQ Sbjct: 601 RIYKSTTDPLKQDPGY---ANIELISEKSAKYWLEGSKAIKKEFPNHVLIGSIMCQHIEQ 657 Query: 115 QWEELARLVQEAGA-DMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 W EL R + G DM+E N SCP MT MG G++P +V+ C+ V +P++ Sbjct: 658 DWRELTRKCKNEGQFDMLELNLSCPHGMTELGMGRACGENPAIVKDICQWVTSEIDIPVI 717 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMP--IVNGKSSIS--G 228 K+TPN D ++A AAK GGA + NT ++ + D +G P V +++++ G Sbjct: 718 VKITPNYPDSADIAQAAKEGGAKAVTLTNTFPTLMDPD---PLGTPWPAVGEENNVTYGG 774 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 G ++PIALR ++ + D I G GGI + A FL GA+ Q+ + + Sbjct: 775 GCGSMLRPIALRKTSEVAK--AIPDIAIFGSGGIIQGDHALSFLRYGASAFQICSAVQDQ 832 Query: 289 GY-RIVEDMASGLSHYL-------------------------ADQGFDSLQEMVGLANNN 322 + ++ D+ + +L A + L+ +VG ++ Sbjct: 833 DFATVLYDLKTSFQAHLYASYNLNQKQWKGQFPTSQKQKPSFAFSSNNKLKNLVGSGLHH 892 Query: 323 IVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCL 382 I ++ R + P+IN D C+ CGRCY++C D G+QA+++ P E C GC Sbjct: 893 IKDIAEMKRQDFLVPQINEDSCLKCGRCYLTCLDSGYQAIKFDNFNSFPTIIEELCTGCA 952 Query: 383 LCGHVCPV 390 LC VCPV Sbjct: 953 LCHAVCPV 960 >UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2ELU8_TRIVA Length = 811 Score = 199 bits (507), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 146/448 (32%), Positives = 220/448 (49%), Gaps = 58/448 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD-HL 64 L FCG+KF NP +SS+PV YE + G G V KTI +V D + Sbjct: 364 LETEFCGMKFKNPSGISSAPVSGTYECIRNCFKAGMGWAVTKTI--LPTKDVIRENDFRI 421 Query: 65 VK--EDTGFIG-FKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI-MGENEQQWEELA 120 VK E+ G G F N+ + EH E L +++LK ++PD+VL+ASI +++++W+ L Sbjct: 422 VKADENPGPSGSFCNICMMTEHTEEYWLDTIKKLKAEFPDRVLVASIATSDSKERWQNLV 481 Query: 121 RLVQEAGADMIECNFSCPQM------------TSHAMGSDVGQSPELVEKYCRAVKRGST 168 + V AGAD +E N SCP T + +G +G P V++ + VK +T Sbjct: 482 KNVIAAGADALELNLSCPNEVHGEGGCKGGFDTENKIGMALGTHPISVKRISQYVKEATT 541 Query: 169 LPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI-- 226 +P K+TPNI D ++A AA GGADG+A INTV I +P V + + Sbjct: 542 VPFFVKLTPNITDPIDIAQAALEGGADGVAMINTVSGIAKF-WPDGTPLPQVGKEKYVLS 600 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 G SG V+PIALR Q R H + + PI GIGGI + A + L G++ Q+ + I Sbjct: 601 GGLSGDQVRPIALR--QISRVHNKFPEMPILGIGGIGSGYTALQHLYAGSSVFQMCSAIQ 658 Query: 287 QYGYRIVEDMASGLSHYL--------------------------------ADQGFDSLQE 314 +Y Y IV ++ +GL YL D+ +L E Sbjct: 659 RYSYDIVREVNAGLQFYLYSWSRPDLRAKLSHYTEMKTLPIQVPIPEDTKQDRKIPTLAE 718 Query: 315 MVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCN 374 + GL +V E D ++ ++ I+ C+ CG+C +SC D +A+ + N Sbjct: 719 LRGLGAKRVVQRESFDINWTLHAEIDDATCLQCGKCALSCRDNSVEAIHLVDGKW--KVN 776 Query: 375 TEKCVGCLLCGHVCPVGCIELGEVKFKK 402 ++C+GC LC VCPV + + E + +K Sbjct: 777 HDECIGCALCHSVCPVQAMHMVESEKRK 804 >UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax=Eukaryota RepID=DPYD_HUMAN Length = 1025 Score = 196 bits (498), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 118/328 (35%), Positives = 175/328 (53%), Gaps = 23/328 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF--IANEVSPRFD 62 D+S+ G+KF NPF L+S+ M +A++ GWG + KT I VSPR Sbjct: 532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPR-- 589 Query: 63 HLVKEDT-------GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM-GENEQ 114 +++ T G F N+E I+E ++ LK D+PD ++IASIM N+ Sbjct: 590 -IIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKN 648 Query: 115 QWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 W ELA+ +++GAD +E N SCP M MG GQ PELV CR V++ +P A Sbjct: 649 DWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFA 708 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI----VNGKSSISGY 229 K+TPN+ D+ +A AAK GGA+G+ A NTV + + + G P + +++ G Sbjct: 709 KLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSD---GTPWPAVGIAKRTTYGGV 765 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG A++PIALR + + L FPI GGI++ E +FL GA+ LQV + I Sbjct: 766 SGTAIRPIALRAVTSIAR--ALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQD 823 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVG 317 + ++ED +GL L + + LQ+ G Sbjct: 824 FTVIEDYCTGLKALLYLKSIEELQDWDG 851 Score = 60.8 bits (146), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 54/94 (57%), Gaps = 2/94 (2%) Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 ++ + ++++++G A + +L V I+ + C+ CG+CY++C D G+QA+ Sbjct: 912 FIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAI 971 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCP-VGCIEL 395 ++ +T P T+ C GC LC VCP V CI++ Sbjct: 972 QFDPETHLPTI-TDTCTGCTLCLSVCPIVDCIKM 1004 >UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q23YG3_TETTH Length = 1080 Score = 185 bits (470), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 127/434 (29%), Positives = 199/434 (45%), Gaps = 60/434 (13%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKT--IGFFIANEVSPRFD 62 D+S CGVK NPF L+S+P Y M A+++D G+ V KT + VSPR Sbjct: 621 DISTEICGVKMENPFGLASAPPTTSYPMIARSFDIGYDFAVVKTAVLDKDTVFNVSPRIF 680 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQWEELAR 121 + + N+E ++E L+ + +++K+DYP+KVLI S+M N+Q W ++ Sbjct: 681 KVPDPLRQECSYGNIELVSEKSLKYWVEGAKQIKKDYPNKVLIGSLMAAYNQQDWIDIMH 740 Query: 122 LVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 V++A DMIE N SCP M MG G+ P++V V + +P++ K+TPN G Sbjct: 741 QVKDAPFDMIELNLSCPHGMNEKGMGRACGEDPDIVRDITSWVTSQTKIPIIVKITPNYG 800 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS----------SISGYS 230 +A AA GGA + NT+ + + P +G+S + G + Sbjct: 801 QAEILAKAAYEGGAKAVTLTNTMPGLVD---------PYPDGESFNGVGVEKNVAPGGST 851 Query: 231 GKAVKPIALRF-IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 G ++P A+R + + PE+ F GGI + + +L GA LQ+ + + Sbjct: 852 GSILRPFAMRKCVDVAKFVPEIDIF---ASGGIISGDHGINYLHYGAKALQICSAVQNLD 908 Query: 290 YRIV---------EDMASGLSHYLADQG---------FDSLQ---------------EMV 316 V +M + S L G F+ L+ E+V Sbjct: 909 AATVFYDLKTSLQANMYANSSQKLKKNGWKGQYPPYQFEKLKTPTSVETPQKVPKILEIV 968 Query: 317 GLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTE 376 G + P E + + I P I+ D C+ CGRCY++C D G+QA+++ P E Sbjct: 969 GAKLAKVSPIEKMSKEIIQVPEISKDSCLECGRCYVACSDSGYQAIQFDGYNNVPRIIEE 1028 Query: 377 KCVGCLLCGHVCPV 390 C GC +C CPV Sbjct: 1029 DCTGCAICVASCPV 1042 >UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MJK5_ALKOO Length = 372 Score = 176 bits (447), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 126/395 (31%), Positives = 201/395 (50%), Gaps = 32/395 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS+ F G+ NP +S+ P+ M KA + G G VV KTI I V PR L Sbjct: 2 DLSVNFLGLSLKNPIIVSAGPLTGSGSMMRKAIEAGAGAVVTKTIANEIRPNVRPR---L 58 Query: 65 VKEDTGFIGFKNMEQIAEHPLEE--NLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 VK G G N+E + LEE N A ++ V+IA+I+G + +A+ Sbjct: 59 VK---GREGLHNIELYSGFTLEEWENEIAYAKIH----GAVVIANILGHTSSEIAYIAQK 111 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSD-VGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 V++ GAD +E SCP H G + V P + ++ +AV +P++ K++ N + Sbjct: 112 VEQFGADAVELGVSCP----HGEGLEGVISEPSKLYEFTKAVVDRIKIPVMVKLSSNTVN 167 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQ-KIGMPIVNGKSSISGYSGKAVKPIALR 240 + ++A AA++ GA I+ I+TV+SI +D+ + ++ +P + GYSG A++PI L Sbjct: 168 VVKLARAAEKAGASAISGIDTVRSIAGVDIEKGRVLLP------TFGGYSGDAIRPIGLA 221 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 I + + PI GIGGI +E E+++LGA+T+QV T I+ GY + + GL Sbjct: 222 AIASI---AQATSIPICGIGGITNYEHILEYMMLGASTVQVCTSIILNGYEHISTLLDGL 278 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 + ++A + + E+ G+A ++ E++ + V + K + C RC SC G + Sbjct: 279 NGWMAQHSYRNFDEIKGMALVSLKSFEEIKQEPYVSQPVGNCKSMQCNRCEKSCIWGAIK 338 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 E R + + C GC LC VCP EL Sbjct: 339 VNR--ENVRV---DRKLCTGCGLCVSVCPQRIFEL 368 >UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine dehydrogenase n=1 Tax=Acyrthosiphon pisum RepID=UPI0001791DE1 Length = 1286 Score = 158 bits (400), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 122/387 (31%), Positives = 176/387 (45%), Gaps = 61/387 (15%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF--FIANEVSPRFD 62 DLS+ CG++F NPF L+S+P M +A+ GW V KT G + VSPR Sbjct: 684 DLSVRMCGLRFMNPFGLASAPPTTSAAMIRRAFQAGWAFAVTKTFGLDKDLVTNVSPRIV 743 Query: 63 HLV---------------------KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPD 101 L D F N+E I+E L ++R LK D+P Sbjct: 744 GLGGHGVGVGSAASGIGPGTLGAGDSDVARNAFLNIELISEKTAAYWLRSIRELKRDFPQ 803 Query: 102 KVLIASIM-GENEQQWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKY 159 +LIASIM E W LARL +AGAD +E N SCP M MG GQ P LVE Sbjct: 804 HILIASIMCAYIENDWTSLARLACDAGADALELNLSCPHGMGESGMGLACGQDPVLVENI 863 Query: 160 CRAVKR-----------GSTLPMLAKMTPNIGDMCEVALAAKR-GGADGIAAINTVKSIT 207 R VKR + +P+ K+TPN+ D+ VA AA R GGADG+ A+NTV ++ Sbjct: 864 SRWVKRVAVRPASDGGTPTAVPVFVKITPNVTDVVAVARAAVRLGGADGVTAVNTVSALG 923 Query: 208 NIDLNQKIGMP--------IVNGKSSISGYSGKAVKPIALRFIQQMRTH--PELR----- 252 +D+ G P +++ G SG AV+P+ LR + + P+ Sbjct: 924 PLDVTGNGGRPWPGVGRTTAETPRTTYGGMSGTAVRPMGLRAVSALSRALGPDATAGGDG 983 Query: 253 --DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL------ 304 I GG+++ ++L GA +QV + + + IV+D +GL L Sbjct: 984 GPPVQIMATGGVDSAAATLQYLYCGAKVVQVCSAVQNQDFTIVQDYITGLKALLYMTGRG 1043 Query: 305 -ADQGFDSLQEMVGLANNNIVPAEDLD 330 +Q + + L ++I ++D D Sbjct: 1044 GEEQQVEQRRPTAALVKDSIDLSDDYD 1070 Score = 70.1 bits (170), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 33/83 (39%), Positives = 46/83 (55%), Gaps = 1/83 (1%) Query: 316 VGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNT 375 VG A + + LDR V +N D C+ CG+CY++C D G+QA+ K+ H Sbjct: 1150 VGRALKAVGAYKSLDRRAQVVALVNEDSCINCGKCYMACNDSGYQAITMDPKSHAVHVQP 1209 Query: 376 EKCVGCLLCGHVCPV-GCIELGE 397 + C GC LC VCP+ GCI + E Sbjct: 1210 DSCTGCTLCLTVCPIPGCISMVE 1232 >UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchaeota RepID=PYRD_METTH Length = 303 Score = 157 bits (397), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 107/320 (33%), Positives = 169/320 (52%), Gaps = 25/320 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF-DHL 64 L + C ++ NP L++ +G+ + Y G G VV K+ +P + + Sbjct: 5 LETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSL----RPNPGYRNPT 60 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 E TG G N ++ +E L+ + E+ P LIAS+ G + +++ A V+ Sbjct: 61 TVEVTG--GVINAIGLSNPGVEAFREELKLVDEEVP---LIASVYGASPEEFASAAASVE 115 Query: 125 EAGADMIECNFSCPQMTSHAM---GSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 E ADMIE N SCP HAM G+ +GQ PEL + AVK +P+ K+TPN+ D Sbjct: 116 EY-ADMIELNVSCP----HAMAGCGASIGQDPELTFRVVSAVKDAVDVPISTKLTPNVTD 170 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+A +A+ G+D + IN++ ID+ K PI++ ++ G SG A+KP+A+R Sbjct: 171 IVEIAGSAEEAGSDALTLINSLGPGMKIDI--KTARPILS--NAFGGMSGPAIKPVAVRC 226 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + + D PI G+GG+ ++DA EFL GA +QV T IM G + + GL Sbjct: 227 VYDVYRS---VDIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGLE 283 Query: 302 HYLADQGFDSLQEMVGLANN 321 ++ +GF S+ EMVGLA++ Sbjct: 284 AFMMAEGFSSVDEMVGLAHD 303 >UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEG1_METST Length = 306 Score = 157 bits (397), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 101/315 (32%), Positives = 168/315 (53%), Gaps = 19/315 (6%) Query: 10 FCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH--LVKE 67 G+K NP L++ +G G GG+V K+ E + +D+ +VK Sbjct: 6 ILGMKLSNPLFLAAGILGTTASSMKMVARAGAGGIVTKSFSI----EANDGYDNPTIVKI 61 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 + G I + +E L L +++ P +IASI G++E+ + ++A ++ Sbjct: 62 EGGVINSVGLASPGVEAKKEELKDLNEIRDKTP---VIASIYGDSEEVFSDVANQTKDY- 117 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPMLAKMTPNIGDMCEVA 186 D E N SCP GS++G++PEL +VK +P++ K+TPN+ D+ E+A Sbjct: 118 VDAFELNVSCPHAKC-GFGSNIGENPELTHDIVSSVKDNIKDVPIIVKLTPNVTDITEIA 176 Query: 187 LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 AA+ GAD + IN+V ID K PI+N + G +G +KPIAL+ + + Sbjct: 177 KAAEDAGADALTLINSVGPGLRIDY--KTARPILN--NVFGGIAGPMIKPIALKCVYKTY 232 Query: 247 THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD 306 E D P+ G+GGI T++DA EFL GA+ LQ+ T IM G I +++ LS++L + Sbjct: 233 ---ETVDIPLFGVGGIRTYKDALEFLYAGASLLQIGTSIMYEGPEIFKNITHDLSNFLEE 289 Query: 307 QGFDSLQEMVGLANN 321 G+ +++E++GL++N Sbjct: 290 NGYKNVEEIIGLSHN 304 >UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+] (DPD) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase) (PydA) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VG14_9BACT Length = 821 Score = 147 bits (372), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 120/415 (28%), Positives = 189/415 (45%), Gaps = 44/415 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L F G K +PF LS++P + YE KAY GW G + KT F ++ +++ Sbjct: 430 LETDFFGRKMDSPFILSAAPPSDGYEQMKKAYLAGWSGGIMKTA--FDNEDIHIPGEYMF 487 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-------ENEQQWEE 118 F N + ++EHPL+ + + L +++PD++ +AS G +++ W+ Sbjct: 488 TFGDKKKTFANCDNVSEHPLDRVCSEIALLIKEFPDRLTMASTGGPVTGDDINDKKGWQA 547 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPMLAKMT 176 +++AGA IE + SCPQ G V Q P L K V S +P L K+T Sbjct: 548 NTIKLEKAGAMGIEYSLSCPQGGDGTKGDIVAQDPALTAKIIDWVMEISNPEIPKLFKLT 607 Query: 177 PNIGDMCEVALAAKR------GGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 + + + A K G GI NT ++ + + I I G S Sbjct: 608 GAVTSIYPILSAVKSVLDKYPGKKAGITLANTFPALAFREKEKPWDEGI------IVGLS 661 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G+++ PI+ + + ISG GG + DAA FL LGA +Q T + +YGY Sbjct: 662 GESILPISYLNLARAGNSGIF----ISGNGGAMNYLDAANFLALGAGNVQFCTIVEKYGY 717 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIV------PAEDLDRSYIVYPRINLDKC 344 I++++ GLS+ L +G S+ E++G+A + P + S I + C Sbjct: 718 GIIDELKMGLSYLLEAKGLKSVAELIGIAQPKPITDFLDLPTKTKSSSLIK------ELC 771 Query: 345 VGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 + CG C Y QA+E E P + +KCVGC LC +C G +E+ K Sbjct: 772 LKCGNCTRCPY----QAIELDEDCY-PKIDPDKCVGCSLCTQLCFAGALEMKNEK 821 >UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus delbrueckii RepID=Q1G992_LACDA Length = 309 Score = 145 bits (366), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 103/323 (31%), Positives = 165/323 (51%), Gaps = 26/323 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGW---GGVVFKTIGFFI-ANEVSPR 60 +L++ G+K NP P + + W G +V KT P+ Sbjct: 6 NLAVELPGLKLKNPVM----PASGTFAFGDLPENFNWDEMGAIVLKTATRHARTGNPQPQ 61 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 D L +G N AE E + ALR E +PD ++AS+ GE+ + + E+A Sbjct: 62 IDLLADGVMNAVGLTNPG--AEVVASEKIPALR---EKHPDLPILASVGGESVEDYVEVA 116 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ A D +E N SCP ++ M G PE++EK R VK LP+ K+TPN+ Sbjct: 117 EILAAAKPDALELNLSCPNVSEGGM--TFGIVPEMLEKITRLVKEKVDLPVYVKLTPNVT 174 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + E+A AA+ GGADG+ INT+ + ++DL + P++ + G G+AVKP+A+R Sbjct: 175 SIVEIAQAAEGGGADGLTLINTLL-VLHLDLKTR--RPVLG--NDFGGLYGQAVKPVAVR 229 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI-VEDMASG 299 + Q++ + PI G+GGI + EDAAEF+L GA+ +Q+ G M + ++ ++ + G Sbjct: 230 MVAQVK---QATSLPIIGVGGINSPEDAAEFILAGASAVQI--GSMSFYDKLAIKHVIDG 284 Query: 300 LSHYLADQGFDSLQEMVGLANNN 322 L LA G + +VG +N Sbjct: 285 LPAVLAGMGASDVTSLVGQWQSN 307 >UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PGY1_9FIRM Length = 371 Score = 144 bits (364), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 113/386 (29%), Positives = 179/386 (46%), Gaps = 26/386 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR-FDH 63 LS+ F G+ NP +++ P K+ D G VV +TI + V PR + H Sbjct: 2 SLSVQFLGMTLKNPVIVAAGPWSCDAAAIQKSIDAGAAAVVTETITLEASTRVCPRLYQH 61 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 G F M + LE+ ++R+ D D +LI S+ G E + +A+ V Sbjct: 62 ------GGSLFNTM-LYSTIDLEQWEQEIKRI--DKRDSILICSVWGATESETAYIAKKV 112 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + GAD IE + S P T + G+S E + Y RAV LP++ K++ + Sbjct: 113 ERLGADAIELSISAPIGTR---STRFGRSQEQIGGYVRAVVEAVDLPVMVKLSYDASANV 169 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 A ++ GA I+AI+++K + +D+ GMP++ + GYSG ++P+AL Sbjct: 170 AFVHAVEQAGAQAISAIDSLKGLAGVDIEH--GMPLM---PTCGGYSGANLRPVAL---A 221 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 T +L I GIGGIE++E E+++LGA +Q+ + ++ GY + + S L + Sbjct: 222 TTATLAQLTRCEICGIGGIESYEHVLEYVMLGANAVQLASTVLLAGYERITRIVSDLRAW 281 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 D +L G A ++P ED+ +V N + CG C SC GG + Sbjct: 282 -TDAHNTTLAAQHGRALQKLIPFEDIPAQQLVCAFQNPCTRIDCGLCAASCLGGGIRLSS 340 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCP 389 T P + C GC LC CP Sbjct: 341 DGFYTVDP----DACTGCGLCAARCP 362 >UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D2W4_DESK1 Length = 407 Score = 142 bits (359), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 123/423 (29%), Positives = 191/423 (45%), Gaps = 53/423 (12%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD-- 62 DLS+ G+K NP ++ PV + D G G VV KTI + + PR Sbjct: 7 DLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTIS--VKPAIVPRPSMA 64 Query: 63 ---------HLVKE-----------DTG---FI-GFKNMEQIAEHPLEENLAALRRLKED 98 HL+K D+G FI N E ++ P E L L + Sbjct: 65 AVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPLVKS 124 Query: 99 YPDK---VLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPEL 155 Y ++ V IASI G ++ L V++AG IE ++H +G D Sbjct: 125 YCEEKGAVFIASI-GYTPEELSLLGPKVEKAGVQAIE-------FSTHYIGRDY----RP 172 Query: 156 VEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 V + +A++ +P+ K++P ++ E+ ++ G DGI A NT+ +ID+ Sbjct: 173 VIEAAKALRESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVET-- 230 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 G+PIV G SG A+KP+AL + Q+ + +L P+ G+GGI D E+ + G Sbjct: 231 GLPIVGGPYGYGWMSGPALKPLALAVVSQVALNTKL---PVIGVGGISRGVDVIEYFMAG 287 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV 335 A+ +Q+ T + G + + ++ +L G+ S+ ++ GLA + P + R + Sbjct: 288 ASAVQICTAALIEGPQAFARIIREVNEWLDRHGYTSILDVKGLALKYLKP--EPRRVWAQ 345 Query: 336 YPRINLDKCVGCGRCYISC-YDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIE 394 P ++ KC+GCG C C YD H +E S R N KC GC LC VCP I Sbjct: 346 PPVVDEKKCIGCGFCEQVCNYDAVH--VEESSGKRVARVNIMKCYGCGLCTSVCPTRAIH 403 Query: 395 LGE 397 E Sbjct: 404 FIE 406 >UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasmatales RepID=PYRD_THEVO Length = 301 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 97/323 (30%), Positives = 172/323 (53%), Gaps = 35/323 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVG-NCYEMCAKAYDTGWGGVVFKTIGF-----FIANEVS 58 D+S T G+K NPF ++S + N Y M + + G VV K+IG + + Sbjct: 3 DISTTLAGIKLVNPFMVASGILDENGYTM-KELLERGAAAVVTKSIGISERDGYPTPVIV 61 Query: 59 PRFDHLVKEDTGFIGFKN--MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW 116 D L+ +G N +E E E N+A + + +I S+ N +++ Sbjct: 62 EYGDSLINA----VGLSNPGIENFGE---EINIAKEAK-------RPIIGSVFAYNAEEF 107 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 +L+ ++E G D IE N SCP + G +VG P+LVE +K +P+ AK++ Sbjct: 108 TKLSVKMEEYGVDAIELNLSCPHV--KGFGLEVGSDPDLVEDIVNEIKSKVKVPVFAKLS 165 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 PN+ ++ E+A AA++ AD INTVK++ ID+ + P+++ + G SG A+KP Sbjct: 166 PNVSNIIEIAKAAEK--ADAYVLINTVKAMA-IDIYSR--SPVLS--NLYGGLSGPAIKP 218 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 + +R++ +++ I G+GGI ++DA E+++ GA+ +Q+ T + +YG I +M Sbjct: 219 VGIRYVYEVKKETGKE---IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYGKGIFREM 275 Query: 297 ASGLSHYLADQGFDSLQEMVGLA 319 L ++ ++ F+ ++EMVG+A Sbjct: 276 EWQLRTFMDEERFEKIEEMVGVA 298 >UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10 Tax=Bacteria RepID=A9BIU8_PETMO Length = 363 Score = 141 bits (356), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 112/398 (28%), Positives = 190/398 (47%), Gaps = 46/398 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 D+S+ G+ P ++ P E KA + G G +V KT+ A P + Sbjct: 3 DISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMAQV 62 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKV-----LIASIMGENEQQWEEL 119 GF N E +E LE+ ++++YP V +I + +E E + Sbjct: 63 KG------GFINTELWSELSLEQ------WIEKEYPQVVETGLPVIIGVGYTSEDIKEVI 110 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 ++ E AD E +++H +G+D P + RA K + LP++ K++P + Sbjct: 111 PKV--ERFADAFE-------LSTHYLGND----PTPMINSIRAAKETTDLPVMVKLSPQV 157 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ + A A+ GADG+ IN+ +IDL G P++ ++ SG+A+ P+AL Sbjct: 158 -DIPKFAKEAENAGADGLVLINSFGPTLDIDLES--GKPLLGSENGFGWLSGQAIFPLAL 214 Query: 240 RFI-QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 R + + +R+ + P+ G+GGI T ++A + ++ GA +QV T + G +I + + + Sbjct: 215 RSVFEAVRS----VNIPVVGVGGINTGKEAIKMIMAGAQAVQVCTAAILNGPQIYKKITN 270 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISC-YDG 357 + YL D F SL+E+ G+A NIV + + +++P +N +KC C C SC YD Sbjct: 271 EIEKYLDDHDFKSLEEIRGIAQKNIVNEANYN---LIFPAVNDEKCTECALCVKSCVYDA 327 Query: 358 GHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 H E + +T KC GC LC C + L Sbjct: 328 IHLIKEL----HSVRIDTNKCAGCGLCVTRCNFNALSL 361 >UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0P959_9FIRM Length = 371 Score = 141 bits (356), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 102/389 (26%), Positives = 170/389 (43%), Gaps = 26/389 (6%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKE 67 I+F G+ NP +++ P K D G V+ +TI SPR + E Sbjct: 5 ISFMGLALKNPLIVAAGPWSGGAAAIQKCIDAGAAAVITETIVMEEPWLFSPRIYYHDDE 64 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 N+ + LEE + R+++D LI SI + + +A+ + G Sbjct: 65 ------LLNLSLYGKRTLEEWEGEVERVRKDSCH--LICSIRASSPSEIAYIAQRTERLG 116 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 AD ++ + P +M D+ PE + ++ A ++P++ ++ N+ Sbjct: 117 ADALQLDLYAPM---DSMIEDIHLQPEKLYEFVHAAASAVSIPVMTRLPYNLAASAPHLH 173 Query: 188 AAKRGGADGIAAINTVKSITNIDL-NQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 A +R G I AI ++++++ +DL Q MP + GY+G+ ++PI+L Sbjct: 174 AVERAGLRAICAIESLRALSGVDLETQTTLMP------TYGGYTGRHIRPISL---AATA 224 Query: 247 THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD 306 T +L D PI G+GG+E + EF++LGAA Q+ + IM +GY ++ L ++ Sbjct: 225 TLAQLTDLPICGVGGVEDYRSILEFIMLGAAAAQLGSAIMLHGYDLITKTVRALEDWMQA 284 Query: 307 QGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSE 366 G+D + G A +++ P E V GCG C C G ME Sbjct: 285 HGYDDYSSITGAALSSLTPFEKAVHRRAVCRMTQPCSRTGCGLCTCGCMYGA-LVME--- 340 Query: 367 KTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 H N+ +C GC LC CP G L Sbjct: 341 -PDGVHLNSSQCTGCGLCVQRCPQGLFHL 368 >UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchaeota RepID=PYRD_UNCMA Length = 301 Score = 141 bits (356), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 101/316 (31%), Positives = 162/316 (51%), Gaps = 35/316 (11%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH----LVKE 67 G+ NP L++ +G + G G VV K+IG P+ H +++ Sbjct: 9 GLTLKNPTILAAGVLGTTGASLKRIASMGAGAVVTKSIG------TEPKPGHHNPSMIRL 62 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 + G+I + + + L R + P +IASI G +++ +A + G Sbjct: 63 EEGYINAMGLPNPSFGEFRQELEIAR--ESGVP---VIASIFGATPEEFTAVANGLP--G 115 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 AD E N SCP + M G PELV +AVK +P+ K+TPN+ D+ + L Sbjct: 116 ADAYELNVSCPHAKGYGM--QCGTDPELVRSITKAVKAAVKVPVWVKLTPNVTDIRPIGL 173 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 AA+ GGAD + AINT+K++ ID+N G PI+ +S G SG AVKP+A++ + + Sbjct: 174 AAQEGGADAVVAINTLKAMA-IDINT--GWPILGNRS--GGLSGPAVKPVAIKCVYDLY- 227 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS---GLSHYL 304 E+ D P+ G+GG+ W DA EF++ GA +++ + + Y + AS G+S+YL Sbjct: 228 --EVLDIPVIGVGGVSNWADAIEFMMAGACAVEIGSAV----YEDIGTFASVSMGISNYL 281 Query: 305 ADQGFDSLQEMVGLAN 320 D+ L E++GLA+ Sbjct: 282 -DRKNMKLDEIIGLAH 296 >UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YYV3_METPS Length = 315 Score = 140 bits (353), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 100/325 (30%), Positives = 165/325 (50%), Gaps = 29/325 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 T L++ G+ NP L++ +G + G G VV K+IG P++ Sbjct: 9 TMKLTVEAGGLTLTNPTILAAGILGTTGASLKRVASMGAGAVVTKSIG------AEPKYG 62 Query: 63 H----LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 H +++ + G+I N + +E L L K+ +IASI G E ++ E Sbjct: 63 HPNPSMIRLECGYI---NAMGLPNPSYKEFLPELETAKDS--GVPVIASIFGATEAEFIE 117 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 +A+ + GA E N SCP + M VG P LV+ AVK P+ K+TPN Sbjct: 118 VAKGLP--GASAYELNVSCPHARGYGM--QVGTDPALVKAIAHAVKGTVNAPVWVKLTPN 173 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ + AA+ GGAD + AINT+K+I ID++ G PI+ G SG A+KP+A Sbjct: 174 VTDITSIGRAAQEGGADAVVAINTLKAIA-IDIDS--GYPILGNIQ--GGLSGPAIKPVA 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +R + + + D P+ G GG+ +W DA EF++ GAA +++ + + + ++ Sbjct: 229 VRCVYDLYSA---LDIPVIGAGGVSSWADAVEFIMAGAAAVEIGSAVYD-DIGVFAAVSM 284 Query: 299 GLSHYLADQGFDSLQEMVGLANNNI 323 GLS YL D+ +L+++ G+A+ + Sbjct: 285 GLSDYL-DRKNMTLKDLTGMAHRMV 308 >UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 Tax=Thaumarchaeota RepID=A9A3M4_NITMS Length = 303 Score = 136 bits (342), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 93/315 (29%), Positives = 158/315 (50%), Gaps = 18/315 (5%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 +L+ + ++ P L+S +G ++ ++ Y +G G VV K++ E P Sbjct: 4 NLATSIGPIQLDRPVMLASGILGISLDVFSRLYRSGAGAVVTKSLSTE-PWEGYPNPTIF 62 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + G+I + +P EN A + +D P +I S++G + +E++ + + Sbjct: 63 SVKGGGWINAVGLS----NPGAENFAKMIEPNQDVP---IIVSLVGSIPEDFEKMIKQFE 115 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 E N SCP + +G +VG PELV+K VK + +P++AK+ Sbjct: 116 NCKVTAYELNLSCPHVAK--VGLEVGDDPELVKKIVTTVKNSTNVPVIAKVGLGTTHYLN 173 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 A G D I AINTV+S+ ID+ + PI++ K G SG +KPIALR + + Sbjct: 174 TVGTAIESGIDAITAINTVRSMA-IDVETQ--RPILSNK--FGGLSGTPIKPIALRCVYE 228 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 + + D PI G GGI TWEDA EF L GA+++Q+ + I + ++ +G+ Y+ Sbjct: 229 ISSK---YDIPIIGCGGISTWEDAVEFFLAGASSVQLGSAIGDNWIDVFNEINTGILQYM 285 Query: 305 ADQGFDSLQEMVGLA 319 + + ++EM+GLA Sbjct: 286 EKKNYSKIEEMIGLA 300 >UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 Tax=Thermosipho RepID=A6LJ97_THEM4 Length = 360 Score = 134 bits (336), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 118/392 (30%), Positives = 181/392 (46%), Gaps = 36/392 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS G+K NP +S P+ YE TG G +V KTI AN P Sbjct: 2 DLSTEISGIKIENPLMPASGPLVGDYEKIKFIDSTGVGAIVTKTISTKAANVPRP----C 57 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLA-ALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 + + F+ N E +E P E + L +LK + K LI S+ G + E L + Sbjct: 58 IYGENNFV--MNAELWSELPPETWIKEILPKLKNEL-KKPLIVSV-GYTIEDMEILIPQL 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 E AD E +++H +G D +V +A+++ + P+ K++P+I D Sbjct: 114 NEY-ADAFE-------ISTHYVGKDYNTIANIV----KAIRKNTNKPIFMKLSPHIPDPV 161 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E GA+GI AIN+ ID+ + + I N K + SG +KPIAL ++ Sbjct: 162 EFTKTILENGANGIVAINSWGPTMKIDIKNRKTL-IGNEKGQV-WLSGPVIKPIALSIVK 219 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 +R D I G+GGI++ ED EFLL GA +Q+ + + +G I E + + L Sbjct: 220 TIRDA--FPDITIIGVGGIKSAEDVIEFLLSGADAVQLLSSALIFGKDIYEKILNQLPST 277 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 L F+S+ E++ N + YP++N +KC CG C C + A++ Sbjct: 278 LEKYEFNSINEVL-----NTELTVGTVKYTPNYPKVNHEKCTLCGICEKVC---PYFAIK 329 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 +K + NT KC GC LC CP I++ Sbjct: 330 IDKKVK---INTYKCFGCGLCESRCPTKSIKI 358 >UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 Tax=Staphylothermus marinus F1 RepID=A3DL41_STAMF Length = 406 Score = 133 bits (335), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 113/420 (26%), Positives = 183/420 (43%), Gaps = 48/420 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF------------- 52 L + G+K NP ++ PV EM D G G VV KTI Sbjct: 4 LEVEIAGLKMKNPLMNAACPVSRDAEMMKALIDNGVGAVVAKTISVRPAIVPRPSMGAVD 63 Query: 53 -------IANEVSPRFDHLVKEDTG---FI-GFKNMEQI----AEHPLEENLAALRRLKE 97 I P +V D+G FI N E AEH E +++ E Sbjct: 64 RGIVRSQILKTFGPGNVRIVNADSGNYRFIYALLNAELWSDIPAEHYFEREYPIVKKYAE 123 Query: 98 DYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVE 157 + +I+ +G ++ + L Q+AGA+ IE ++H +G D V Sbjct: 124 EKGVPFIIS--IGYKPEELQLLGPKCQKAGANAIE-------FSTHYIGKDY----RPVV 170 Query: 158 KYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGM 217 + +A++ +P+ AK++P ++ E+ ++ G DGI A NT+ +ID+ + G+ Sbjct: 171 EAAKALREVVDIPIFAKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDI--ETGL 228 Query: 218 PIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAA 277 PIV G + SG A+KP+AL + + + L P+ G+GGI D E+ + GA+ Sbjct: 229 PIVGGPNGYGWMSGPALKPLALAVVAEAAKNTHL---PVIGVGGISKGTDVIEYFMAGAS 285 Query: 278 TLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYP 337 +Q+ T + G + + + +L G+DS+ ++ G A + P + R + P Sbjct: 286 AVQICTAALIEGLGVFRRIEKEIESWLKRHGYDSILDVKGKALKYLKP--EPRRVWAKPP 343 Query: 338 RINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGE 397 ++ KC+GCG C C + + E R N + C GC LC VCP I E Sbjct: 344 VVDPKKCIGCGFCEQVCDYNAVKVVPNEEGKRIAQVNYDLCYGCGLCTSVCPTRAIHFEE 403 >UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga lettingae TMO RepID=A8F8E8_THELT Length = 386 Score = 128 bits (321), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 103/398 (25%), Positives = 183/398 (45%), Gaps = 27/398 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSP--RFD 62 DLS + G+K NP ++SS + + KA + G VV K++ +SP RF+ Sbjct: 2 DLSCEYVGIKLKNPIIVASSGLAENLKNMKKAEEHGAACVVAKSLFEEKICRISPTPRFE 61 Query: 63 HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 +++ G + F + EQ + E +R+ V I SI ++ W + Sbjct: 62 -IIERKMGKLRSQTFYSFEQASPFDAHEYFEEIRKAVNTLSIPV-IPSINCVTDEGWSQY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 AR+ + AGA +E N SCP + G DV E + + V+ +P++ K+ + Sbjct: 120 ARMAEGAGAPALELNVSCPHGSISFRGGDV---EEKILSVAKIVRDSVKIPLIVKLPMQL 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 +A +R G DG+ N +T +D+N + P+++ +G+ G L Sbjct: 177 SSPLSMAKMLERSGIDGVVMFNR---LTGLDINLEKERPVLH--EGYAGHGGPWAFNYVL 231 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I H + ++ GG+ + ED +++ GA ++V + I GY ++ + Sbjct: 232 RWIAASSPH---LNISVAASGGVGSGEDIIKYIYAGANAVEVCSLIYLSGYEAIDMLLEQ 288 Query: 300 LSHYLADQGFDSLQEMVG-LANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISC-YDG 357 + ++ + + ++ G L+ I+ E +DR ++ +IN C CG C C YD Sbjct: 289 IKAFMERKSYPDFSQIKGKLSGKAILSNEQIDRRHLFKAQINQALCTSCGTCQKVCIYDA 348 Query: 358 GHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 +Q SEK+ + +E C GC LC +CPV IE+ Sbjct: 349 PYQ----SEKS---YVISELCDGCGLCVKLCPVKAIEM 379 >UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (Dhodehase) (Dhodase) (Dhod) n=3 Tax=Hydrogenothermaceae RepID=C0QU30_PERMH Length = 320 Score = 127 bits (318), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 98/324 (30%), Positives = 164/324 (50%), Gaps = 23/324 (7%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIANEVSPR 60 L LS G+KF NP +S E+ YD G VV K + + P+ Sbjct: 8 LKDPLSYELFGIKFKNPVWTASGCFSYGLEVAQNLYDISELGAVVVKGLSYRPREGNPPQ 67 Query: 61 FDHLVKEDTGF---IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 +V+ G IG +N E+ ++ L LR D V++A++ GE+E ++ Sbjct: 68 --RIVETPCGMLNSIGLQNPG--VEYFIKNILPQLREY-----DTVIVANVFGEDEDEYL 118 Query: 118 ELARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 ++A ++ +A G D++E N SCP + G G PE + +K+ P+L K++ Sbjct: 119 KVAEVLNKADGVDLLELNVSCPNVKKG--GIAFGSDPETLFNLVYRLKQVMEKPLLVKLS 176 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 PNI D+ + A A+ GADG+ INT+ + ID++++ PI+ ++ G SG A+ P Sbjct: 177 PNITDILDTATASVEAGADGLVLINTLLGMA-IDIDKE--EPIIGMRT--GGLSGPAILP 231 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 +A+R I Q+ PI G+GGI T +DA + +L GA ++Q+ T Y ++ + Sbjct: 232 VAVRMIYQVYEKYG-SSVPIIGVGGITTAQDALQHILAGAVSVQIGTANFYDPYSPLK-V 289 Query: 297 ASGLSHYLADQGFDSLQEMVGLAN 320 GL +L +G+D ++VG A+ Sbjct: 290 IKGLKEHLDKKGYDHFLQLVGKAH 313 >UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A1L2_THESM Length = 309 Score = 124 bits (310), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 100/325 (30%), Positives = 161/325 (49%), Gaps = 33/325 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH- 63 DLSI G+KF NP L+S PVG +E+ + G + KT+ + PR + Sbjct: 4 DLSIDVFGIKFRNPIILASGPVGFGFELMPYLDFSNIGAITLKTV------TLKPREGNP 57 Query: 64 ---LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 LV G I ++ E +A RLKE K I SI G + +WE L Sbjct: 58 PPRLVDSHGGVINSIGLQNPGIEGFVEEIAP--RLKELKTIK--IGSIAGFSMDEWEILG 113 Query: 121 R-LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + + +IE N SCP + + + +L EK + V++ + P++AK+ P++ Sbjct: 114 EEMDKIKEIKIIEINLSCPNVKGKRRWA---EDAKLTEKVVKIVRKLTGKPIIAKLAPDV 170 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E+A A GADG+ N +++ ++ + G+PI+ K+ G G AVKPI L Sbjct: 171 TDIVEIAKTAVDAGADGLTIGNGAQAMR---IDVETGLPILKLKTG--GLGGPAVKPITL 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM---QYGYRIVEDM 296 + + R E D PI GIGGI W+DA E+ + GA+ L + T +M + RI+E Sbjct: 226 AKVFKTR---EALDVPIIGIGGIMNWQDAIEYAMAGASLLGLGTAVMVDPEAPVRIIE-- 280 Query: 297 ASGLSHYLADQGFDSLQEMVGLANN 321 G+ +L + +S +++G+A+ Sbjct: 281 --GIKAFLERKKIESFNKIIGVAHK 303 >UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium carboxidivorans P7 RepID=C6Q0J2_9CLOT Length = 360 Score = 122 bits (305), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 102/394 (25%), Positives = 187/394 (47%), Gaps = 39/394 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPV---GNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 +L++ G+K NP +S P +C C K G G +V KTI P Sbjct: 3 NLNVDLHGIKIKNPIMPASGPQVRNADCMLECVK---QGVGALVTKTISEKFVRTARPCM 59 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 ++T F N E +E +E+ + + Y +++ +G ++ E++ Sbjct: 60 -----QETKDGAFLNSELWSELSVEQWVEKGYSKCKSYGVPFIVS--LGYTAKEIEKVLP 112 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ AD+IE +++H M D+ + ++ + S P+ K++P I Sbjct: 113 IITPY-ADIIE-------ISTHYMEKDLESVVDSLK-----IASKSDKPVYIKISPGITK 159 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + GA G AIN++ +ID+ + G+P + G+ SGK++ PIALR+ Sbjct: 160 IGWYVKRLVEEGAAGFVAINSLGPCLHIDV--ETGLPYLGGEKGYGWLSGKSLNPIALRY 217 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + + ++ P+ G+GGI + EDA ++ GA+ +Q+ T + G + +++ L+ Sbjct: 218 VYSIANSVKV---PVIGVGGISSGEDAVAMIMAGASAVQICTAAILEGNGVYSRVSNELN 274 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQA 361 +L GF+S++++ GL + + + ++P+IN +KC CG+C SC + A Sbjct: 275 SWLDAHGFESVEDIRGLTARKMQERKVIREP--IFPKINKEKCNSCGKCVKSC---AYSA 329 Query: 362 MEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 + S+K + NT KC GC LC CP IE+ Sbjct: 330 ITISDKA---NINTTKCFGCGLCLTRCPETAIEV 360 >UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotate dehydrogenase B) catalytic subunit n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q4L5_9BACT Length = 306 Score = 121 bits (304), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 85/322 (26%), Positives = 158/322 (49%), Gaps = 17/322 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 M LSI C ++ NP L+S +G + + ++G G V K++ ++ S Sbjct: 1 MTEVTLSINLCSMRLSNPTVLASGILGTTKTLLKRVAESGAGAVTIKSV-----SKDSRE 55 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKE-DYPDKVLIASIMGENEQQWEEL 119 H T G N + +E L E P +IASI+G + E+ Sbjct: 56 GHHNPTVITYEAGMLNAVGYSNPGVEAARIEYSNLNEIGVP---VIASIIGTCTDDFIEV 112 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 A + +G IE SCP + S G +P+ + AV+R + +P+ K++PN+ Sbjct: 113 AEGLSASGFSAIEIPLSCPHTPGFGLLSGQG-TPKATYEITYAVRRKTNVPIFVKISPNV 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 ++ +A AA+ GA+GI A+N++ I++ K P++ K + G +G A++PIA+ Sbjct: 172 PEITSIAKAAEDAGANGITAVNSMGPGMVINIESK--KPVLGFK--VGGVTGDALRPIAV 227 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + + + PI G+GGI T A E ++ GA+ + + TG+ G + + + Sbjct: 228 RCVYDVY---QAVKIPIIGVGGISTGRHAIEMMMAGASAVGIGTGVYTRGINVFSKVCAE 284 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 + ++ + G++++ E+VG+A++ Sbjct: 285 MKQWMIENGYNTINELVGVAHD 306 >UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B8E1W3_DICTD Length = 390 Score = 120 bits (302), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 105/401 (26%), Positives = 185/401 (46%), Gaps = 33/401 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEV-----SP 59 DLS ++ G++ NP ++SS + + K + G G +V K++ E+ +P Sbjct: 2 DLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSL---FEEEICRVSPTP 58 Query: 60 RFDHLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW 116 RF+ ++ G + F + EQ + EE + + V I SI + W Sbjct: 59 RFE-IISRSMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLSIPV-IPSINCITDDGW 116 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 + +++ +E GA +E N SCP + G DV E + R V+ +P++ K+ Sbjct: 117 LKYSKMAEEVGAPALELNVSCPHASISFRGQDVD---ETILHVARIVRENVKIPIVVKLP 173 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 + VA A + G DG+ N +T +D+N PI++G +G+ G Sbjct: 174 MQLSSPLAVAKALENIGVDGVVMFN---RLTGLDINLDTEKPILHG--GYAGHGGPWAFN 228 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 LR+I R H +L I+G GG+ + +D A+++L GA +Q+ + + GY I+ + Sbjct: 229 YVLRWISTSRPHLKLS---IAGSGGVGSGDDVAKYILTGADVVQICSIVYLMGYEIIPRI 285 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVPAE-DLDRSYIVYPRINLDKCVGCGRCYISC- 354 GL ++ ++ + +L + G + ++ ++DR ++ IN D C CG C C Sbjct: 286 IDGLKKFMENKKYSTLSDFRGKVSGKVILGNYEIDRRHLYEAYINSDLCTSCGICKKVCI 345 Query: 355 YDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 YD +E K + T+ C GC LC +CP I + Sbjct: 346 YDA---PIEKDGK----YFITDLCDGCGLCVRLCPTKAISM 379 >UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHS6_KOSOT Length = 361 Score = 120 bits (300), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 108/392 (27%), Positives = 175/392 (44%), Gaps = 40/392 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DL+ G++ NP +S P+ + D G G +V KTI A P Sbjct: 2 DLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRP----C 57 Query: 65 VKEDTGFIGFKNMEQIAEHPLEE---NLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + +I N E E+P E+ R K P LI S +G + E L Sbjct: 58 IIAGKNYI--MNTELWTEYPPEKWKGEFIPKFREKSSLP---LIVS-LGYTVEDLEVLVP 111 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + + AD E +++H + D PEL++ R VK+ + P+ K P++ + Sbjct: 112 MFDDL-ADAFE-------LSTHYVADD----PELMKHLIRTVKKHTDKPVFLKFDPSVPE 159 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 +A A + G DGI AIN++ L +++ + SG +KPIAL Sbjct: 160 PEVMAKAVEEAGGDGIVAINSLGP--GYPLYRELKSSPLGSTHGFGWISGPVIKPIALAM 217 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 ++++ + L PI G+GGI + +D +F++ GA+ +Q+ +G + YG I + + + L Sbjct: 218 VKRVASSCNL---PIIGVGGISSADDVIDFIMAGASAVQLLSGALLYGKSIYKKIIADLP 274 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQA 361 L G++S+ E+ GLA N+ R+ P+I+ KCV CG C C + A Sbjct: 275 KKLEALGYNSINEIKGLATNSNPEVSYEKRT----PKIDHSKCVKCGVCVEVC---PYFA 327 Query: 362 MEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCI 393 + E+ + E C GC LC CP I Sbjct: 328 LSMEEQVIV---DEEACFGCGLCQTKCPTKAI 356 >UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 Tax=Archaea RepID=A1RZC9_THEPD Length = 299 Score = 119 bits (297), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 95/321 (29%), Positives = 162/321 (50%), Gaps = 28/321 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH- 63 +LS+ G++ NP ++S +G + +A D G G V KT+ ++PR + Sbjct: 3 ELSVEVAGLRLRNPVVVASGVLGVSVGLMKRAEDAGAGAVTSKTV------TLNPREGYP 56 Query: 64 --LVKE-DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 +V E D G + + +P E + + R +IASI + +A Sbjct: 57 NPVVYELDYGLVNSMGLP----NPGAEEMGRILREARRVLGIPVIASIGASTPDEALRIA 112 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ G D +E N SCP + +G+D+ P+ V A+K S + K++P+ G Sbjct: 113 EALE--GFDALELNASCPHV--KGLGADLMSDPDAVYGIVSALKS-SGYRVFLKLSPH-G 166 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D VA A G DG AINT K++ ID+ + P++ G SG+A+ PIA+R Sbjct: 167 DYLAVARKAYSAGVDGFTAINTAKAMV-IDVYAR--KPVLGGVVGGL--SGRAIHPIAVR 221 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ H E + P+ G GG+E W +A E +L GA+ + V T ++ G+ ++ ++ G+ Sbjct: 222 VVYEL--HREFPEVPVIGTGGVEGWVEAVELILAGASAVGVGTA-LKRGFEVIGEILGGI 278 Query: 301 SHYLADQGFDSLQEMVGLANN 321 YL D+GF S++ +VGLA+ Sbjct: 279 ERYLRDEGFPSVESIVGLAHK 299 >UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 Tax=Clostridiales RepID=C4IB41_CLOBU Length = 362 Score = 116 bits (291), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 112/396 (28%), Positives = 180/396 (45%), Gaps = 46/396 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSP-VGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ T +K NP +S P VG+ +M A + G G +V KTI A V P Sbjct: 2 NLNTTIGKIKLENPLMPASGPLVGDKDKMSA-LNEFGVGAMVTKTISSKKAEVVRP---- 56 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + FI N E +E+ E + L +K++ DK LI S+ E + +L Sbjct: 57 CIYGGKNFI--MNAELWSEYAPEVWIDEFLPSIKKELKDKPLIISVGYTKEDMEFLIPKL 114 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + AD E +++H +G D+ +++ + ++R + P+ KM+P+I D Sbjct: 115 --DVFADAFE-------ISTHYVGKDLSN----IKETLKTIRRFTQKPVFMKMSPHIPDP 161 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 A GI AIN++ NID++++ ++ K SG A+KP+AL I Sbjct: 162 IGFAKMVIENKGSGIVAINSLGPTMNIDIDKR--SVLIGNKEGEVWTSGPAIKPMALALI 219 Query: 243 QQMRTH-PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 +++ PE I G+GGI + +D EFLL GA+ +Q+ + M G + E + L Sbjct: 220 HKIKKAVPECE---IIGVGGISSADDIIEFLLAGASAVQMLSAAMLKGKDLYEKLIEELP 276 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV----YPRINLDKCVGCGRCYISCYDG 357 L GF+S++E++ E L + YP IN DKC C C +C Sbjct: 277 KALKKHGFNSVEEVIN---------EKLSIGQVKYEPEYPLINKDKCTNCRLCEKACPYF 327 Query: 358 GHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCI 393 +++ K +T+ C GC LC CP I Sbjct: 328 AITSIDNQIKI-----DTKNCFGCGLCESRCPSKAI 358 >UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9KKE5_9FIRM Length = 316 Score = 116 bits (291), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 80/239 (33%), Positives = 126/239 (52%), Gaps = 16/239 (6%) Query: 82 EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMT 141 EH L+E L +++ + +I +I G + + +LA L+ G IE N SCP + Sbjct: 81 EHFLKETLPRIQQYGMN-----VIVNISGSTAEDYGKLAGLLDVPGVAAIELNVSCPNVK 135 Query: 142 SHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAIN 201 G G PE RA K + P++ K++PN+ D+ +A A + GAD ++ IN Sbjct: 136 EG--GIVFGTDPEAASAVVRAAKAHTKKPVILKLSPNVTDIVAMAKAVEAAGADAVSLIN 193 Query: 202 TVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGG 261 T+ + ID+++ P++ + G SG VKP+A+R + Q+ + PI G+GG Sbjct: 194 TLLGM-EIDIHRF--RPVLGNIT--GGLSGPCVKPVAVRMVWQVA---QAVHIPIIGMGG 245 Query: 262 IETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 I + EDA EF L GA+ + V T I + GL+ YLA+ GF S++E+VG AN Sbjct: 246 IASAEDAVEFFLAGASAVAVGTANFT-DPEITMKICDGLTDYLAENGFSSIEEIVGKAN 303 >UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfurococcales RepID=PYRD_AERPE Length = 306 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 100/323 (30%), Positives = 157/323 (48%), Gaps = 29/323 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS--PRFD 62 +LSI+ G++ P +S +G A+ + G GG FF+A V+ PR Sbjct: 6 ELSISIAGLRLQRPVGNASGILG-WEPREARLVEEGGGG-------FFVAKSVTYQPRKG 57 Query: 63 ----HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 HL G + N +A E L + E+ V IASI G +W E Sbjct: 58 YPQPHLYPVAGGIV---NAVGLANPGFREASKMLAQTVEEASIPV-IASIAGGAPGEWVE 113 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 +A ++EAG +E N SCP G ++GQ P V AV +P++AK+ + Sbjct: 114 MASTLEEAGVSAVELNLSCPHFAGG--GLELGQDPAAVASVVSAVASTLRIPVIAKLGYS 171 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + + A A GA G+ IN+++++ ID+ K P++ + + G SGK + PIA Sbjct: 172 -DRLVDAASKALEAGARGLTLINSMRAM-KIDVYAK--KPVLGNR--VGGLSGKPIHPIA 225 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +R + ++ + E R I GG+E+WEDA EF L GA +QV + G ++ + Sbjct: 226 VRAVYEV--YGETRA-DIFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIVE 282 Query: 299 GLSHYLADQGFDSLQEMVGLANN 321 G+ YL +GF SLQ++VG A+ Sbjct: 283 GVRRYLWVEGFRSLQDIVGYAHR 305 >UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=PYRD_SOLUE Length = 304 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 94/319 (29%), Positives = 151/319 (47%), Gaps = 22/319 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPR 60 +T L+ T CG+ NP +S E GG V K + I PR Sbjct: 1 MTPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHP-LEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + + + G I ++ I + E L AL L+ + A++ G + + E+ Sbjct: 61 ---VFESEAGMINSVGLQNIGVRAFVAEKLPALAGLR-----TAVFANVFGYCTEDYVEV 112 Query: 120 ARLVQE-AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R++ + AG E N SCP T+H G P L+ + A KR +T P++ K++PN Sbjct: 113 VRVLNDHAGLAGYELNVSCPN-TAHG-GIYFSNDPVLLAEVVTAAKRVATRPLIVKLSPN 170 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + + +A A+ GAD ++ +NTV S+ ++ + P + + G SG A+KPIA Sbjct: 171 VSAIEPLARVAEESGADALSLVNTVISLA---IDARTRRPRIG--AGFGGLSGPAIKPIA 225 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LRF+ Q + P+ G+GGI T EDAAEFL+ GA+ ++V T + R +A Sbjct: 226 LRFVYQAARAVRI---PVIGLGGIATGEDAAEFLIAGASAVEVGTATF-WDPRAPLRIAE 281 Query: 299 GLSHYLADQGFDSLQEMVG 317 L +L +G ++VG Sbjct: 282 ELGKFLEREGIRKATDLVG 300 >UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D3W9_DESK1 Length = 302 Score = 115 bits (288), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 96/319 (30%), Positives = 161/319 (50%), Gaps = 20/319 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + + L + G++ +P +S +G+ E G+ +V KTI P Sbjct: 1 MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 ++ + G N +A +P + L R K K LI SI G + +++ +LA Sbjct: 61 IVELRNN----GLLNAVGLA-NPGARVIPVLAR-KARELSKPLILSIGGSSVEEFVKLAE 114 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 L EAG D +E N SCP + G ++G P LV + + ++LP++AK+ + D Sbjct: 115 LASEAGVDAVELNLSCPH--AEGYGLELGSDPMLVYRIVKDAVSVASLPVIAKL--GLTD 170 Query: 182 -MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + E A A G + INTVK+++ ID+ P+++ K G SG + PIA+R Sbjct: 171 RVIESAGKALEAGVKALTLINTVKAMS-IDVYTL--KPVLSNKY--GGLSGPPIHPIAVR 225 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + + E R I G+GG+ +W D AE +L GA +QV T ++ + IV+++ SGL Sbjct: 226 VVYDV--YREYRA-EIIGVGGVSSWMDVAELILAGARAVQVGTALI-WNENIVDEILSGL 281 Query: 301 SHYLADQGFDSLQEMVGLA 319 +L D G++SL ++VG+A Sbjct: 282 HKWLIDLGYNSLMDLVGIA 300 >UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=PYRD_UNCTG Length = 306 Score = 113 bits (283), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 92/324 (28%), Positives = 156/324 (48%), Gaps = 28/324 (8%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + DLS+ F G+K NP +S G YE+ GGVV KT+ A + PR Sbjct: 1 MIPDLSVNFAGIKLKNPVLTASGTFGYGYELADLIPLKRLGGVVTKTVTLEPRAGNLQPR 60 Query: 61 FDHLVKEDTGFIGFKNM--EQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + IG +N+ E PLE + K P +I S+ G ++ E Sbjct: 61 IAEVASGILNSIGLQNIGVRAFIEEPLE------KLNKIGVP---VIVSVAGVAVGEYVE 111 Query: 119 LARLVQ-EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + +++ + G IE N SCP + + D+ L+ R VK+ S +P++AK++P Sbjct: 112 IVKILSSQNGVSAIELNLSCPNLKKKIVCHDL----PLMRDVIRGVKKVSRVPVIAKLSP 167 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQ-KIGMPIVNGKSSISGYSGKAVKP 236 + D+ E+AL A+ GADG+ NT ++ +D+ K + V G G SG +KP Sbjct: 168 LVTDISELALTAQNAGADGVTLTNTYPAMA-VDIRTFKPKLSTVKG-----GMSGACIKP 221 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 +++R + + +++ PI G GGI EDA EF+L GA + V + + ++ + Sbjct: 222 MSVRCVYD--AYQDIK-IPIIGCGGIMMGEDAVEFILAGATAVSVGSSSLVSPGNLIA-I 277 Query: 297 ASGLSHYLADQGFDSLQEMVGLAN 320 G+ L ++ S+++++G N Sbjct: 278 IDGIEDILKEKNIKSVKKIIGGIN 301 >UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic subunit n=1 Tax=Oceanicola batsensis HTCC2597 RepID=A3U0T3_9RHOB Length = 314 Score = 110 bits (275), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 89/286 (31%), Positives = 136/286 (47%), Gaps = 32/286 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIANEVSPRFDH 63 DLS+T GV+ NP +S G+ E A D G G +V KTI + V P Sbjct: 3 DLSVTVGGVRMKNPVMPAS---GSIAEGMADVVDLGRLGAIVLKTITPDLRQGVKPPRVV 59 Query: 64 LVKEDTGF---IGFKNMEQIAEHPLEENLAALRRLKEDYPDKV---LIASIMGENEQQWE 117 + T F I K + + H + + DK +IASI + + + Sbjct: 60 EYTDATLFSIGIPSKGPDYLLNHTVP------------FFDKFGPPVIASISADTVEDFG 107 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 +LA + + IE N SCP + +H G G P + A+K +TLP+ AK+TP Sbjct: 108 KLAGYITDPRIAAIEANISCPNLRAH--GRAFGMDPVASAQVITAMKANTTLPIWAKLTP 165 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 N+GD+ E+A + GAD A+ T +I + ++ + P + + + G +G AVKP+ Sbjct: 166 NVGDIAEMARCVEGAGAD---AVITANAILGMAIDAETMTPRLG--NVVGGLTGPAVKPV 220 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 LR + Q E P+ G GGI T ED E++L GA+ +Q+ T Sbjct: 221 ILRMVNQCA---EAVKIPVIGCGGIATGEDVVEYMLAGASAVQIGT 263 >UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales RepID=PYRD_SULSY Length = 311 Score = 110 bits (274), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 97/328 (29%), Positives = 164/328 (50%), Gaps = 32/328 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGW-GGVVFKTIGFFIANEVSPRFDHL 64 L T G++F NP +S E+ AK YD G +V K G + + + Sbjct: 4 LKHTLFGLEFKNPVWTASGTFSYGLEV-AKIYDLSLLGAIVVK--GLSLKPRKGNMPERI 60 Query: 65 VKEDTGF---IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA- 120 V+ G IG +N ++ + E L L++ D + A++ GE+E ++ +A Sbjct: 61 VETPAGMLNSIGLQNPG--VDYFINETLPKLKKY-----DTKIFANVFGEDEDEYLAVAE 113 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 RL + G +E N SCP + G G PE++ +K+ + P+L K++PN+ Sbjct: 114 RLDKADGVHGLELNVSCPNVKKG--GIAFGTDPEVLYNLVYKMKKITKKPLLVKLSPNVS 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS-GYSGKAVKPIAL 239 ++ + A A GADG+ INT+ + ID+ ++ PI+ S+I+ G SG A+ PIA+ Sbjct: 172 NILDTADACVSAGADGLVLINTLLGVA-IDVERE--KPIL---STITGGLSGPAMLPIAV 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ---YGYRIVEDM 296 R I Q+ R PI G+GGI ++DA + +L GA+ +QV T +I+ED Sbjct: 226 RMIWQVYQKYGSR-IPIIGVGGISNYKDALQHILAGASAIQVGTANFYDPLSPLKIIED- 283 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIV 324 L ++L +G+ +++G A+ I+ Sbjct: 284 ---LKNHLDKKGYVHYSQLIGKAHQMII 308 >UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 Tax=Planctomycetaceae RepID=D2QWH7_9PLAN Length = 315 Score = 109 bits (273), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 101/317 (31%), Positives = 154/317 (48%), Gaps = 25/317 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS+T ++ NP +S G EM + + GG++ KT+ PR + Sbjct: 12 DLSVTLGRLRLRNPILTASGTFGYAREMESLVDFSKLGGILPKTV------TQQPRAGNT 65 Query: 65 ---VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA- 120 E T G N + +E +A P +++ SI G N ++ +A Sbjct: 66 PWRTVETTA--GLLNAIGLDNDGIETFIAHHMPYLGSLPTSIIV-SIAGSNHNEFVAMAG 122 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 RL G IE N SCP + A G D G L EK + + P+LAK+TPN+ Sbjct: 123 RLSDIDGIAAIELNISCPNV---AHGIDFGADASLCEKLVSDCVKATRHPILAKLTPNVT 179 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + +VA A GGAD ++ INTV+ + ID ++ P++ + + G SG A+KPIALR Sbjct: 180 RIADVAKGAANGGADALSLINTVQGMA-IDWRKQ--KPLLG--NVMGGLSGPAIKPIALR 234 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q+R + PI GIGGI T +D EF++ GA+ +Q+ T Y + +A+ L Sbjct: 235 CVHQVR---QAVSTPIIGIGGIATIDDVMEFIVAGASAVQIGTA-NYYDPTVTMKLAAAL 290 Query: 301 SHYLADQGFDSLQEMVG 317 L + G S+ E+VG Sbjct: 291 PFALQEIGAKSIAEVVG 307 >UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Leuconostoc citreum KM20 RepID=B1MZ73_LEUCK Length = 306 Score = 109 bits (273), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 93/325 (28%), Positives = 156/325 (48%), Gaps = 35/325 (10%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGW-----GGVVFKTIGFFIAN 55 M+++ L++ G+ NP SS V E D G+ G +V KT+ A Sbjct: 1 MMSERLAVKLPGLDLKNPIMNSSGAVFFGLE------DKGYAIEETGALVTKTVTMS-AR 53 Query: 56 EVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLA-ALRRLKEDYPDKVLIASIMGENEQ 114 +P+ ++ +G + N +A +E +A L + E Y ++AS+ GE Sbjct: 54 AGNPQ-PWIINTPSGIL---NSVGLANPGIEAVVADILPAIHEKYKTLPVLASVAGETVG 109 Query: 115 QWEELA-RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 ++ L RL IE N SCP + M G + E + A++ +TLP+ A Sbjct: 110 EYVALTERLTATKQVTAIEANLSCPNVDRGGMA--FGVTAESAAEVIHAMRAATTLPIYA 167 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 KM+PN+ D+ + A + GADGI INTV ++ +DLN + + G G SG + Sbjct: 168 KMSPNVTDIKPIVKAVETAGADGIVLINTVVGMS-LDLNTRQAR-LARGT---GGMSGTS 222 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM---QYGY 290 V PIA+RF+ + + P+ G+GG+ T +D E ++ GA+ +Q+ T + Q Sbjct: 223 VHPIAVRFVYETA---QTVSIPVIGVGGVSTVDDVLELMMAGASAVQIGTALAGNHQVMA 279 Query: 291 RIVEDMASGLSHYLADQGFDSLQEM 315 I+ ++ S L Y GF +++E+ Sbjct: 280 DIIRELPSALDKY----GFSNVEEV 300 >UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=C8WHP0_EGGLE Length = 356 Score = 108 bits (270), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 86/320 (26%), Positives = 143/320 (44%), Gaps = 31/320 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 D+ + G++ NP ++S E G G V K + A SPR Sbjct: 57 DMRVNLGGLEMKNPVTVASGTFAAGREYGDFVDVAGLGAVTTKGVSLNGWAGNASPRIAE 116 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKE-DYP-----DKVLIASIMGENEQQWE 117 IG +N + LKE D P +I ++ G + ++ Sbjct: 117 TPSGMLNSIGLQN-------------PGVAHLKECDLPWLAERGATVIVNVSGHSFDEYV 163 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 ++ +++ D E N SCP + A G +G + VE + + P++ K+TP Sbjct: 164 QVIEALEDVPVDAYEVNISCPNV--DAGGMTIGTCTDSVEAVVSRCRAATKRPLIVKLTP 221 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 N+ D+ E+A AA GAD ++ INT+ + ID ++ P + + G SG AVKP+ Sbjct: 222 NVTDVTEIARAAVSAGADALSLINTLLGMA-IDAERR--RPQL--ARGVGGLSGPAVKPV 276 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 ALR + ++ + D P+ G+GGI DA EF+L GA + V T + VE + Sbjct: 277 ALRMVWEVH---QAVDVPLLGMGGISCATDAVEFMLAGATAVAVGTANFVNPHATVE-II 332 Query: 298 SGLSHYLADQGFDSLQEMVG 317 G++ Y G + +Q+++G Sbjct: 333 DGMAQYCERHGIEDVQQLIG 352 >UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2EKA7_TRIVA Length = 365 Score = 107 bits (268), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 110/402 (27%), Positives = 176/402 (43%), Gaps = 51/402 (12%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 L F G + NP + P + C G G +V KTI +A P+ + Sbjct: 2 SLKTKFAGYEVKNPLMPAPGPPVRDAKACIDCIKGGCGVMVTKTIS--VAAAKVPQPNMY 59 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPD--------KVLIASIMGENEQQW 116 +D + F N E L L + L+ +YP K+ + MG Sbjct: 60 ESKDHKY--FLNTE------LWTELTPEQWLEHEYPKIREVCNQAKIPMICSMGYTA--- 108 Query: 117 EELARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-LPMLA 173 EE+A++ + D +E +++H +G D P+ ++ +A GS P+ Sbjct: 109 EEIAKMAPKVAPFCDGLE-------LSTHYIGDD----PKPMQDAIKAAIHGSGGKPVYV 157 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K++P D A AAK GA G+ +N+ +D+ +K G P + S SG A Sbjct: 158 KLSP-FRDAPIAAKAAKAAGATGLVCVNSFGPTLALDIERK-GAPFMGSTSKYGWVSGPA 215 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 +KP+ALR + + D P+ G+GGI DA EFL+ GA L + T + G + Sbjct: 216 IKPLALRVVYDVCKE---VDLPVVGVGGISNGRDAIEFLMAGAQALGICTAAIVEGRDVY 272 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYIS 353 +A +S +L + G+ + E++GL + E L + P+I +KCVGCG C S Sbjct: 273 GSIAQEMSQWLTEHGYKDIHEVIGLGLKH----EPLQQHNP--PKIAAEKCVGCGTCVTS 326 Query: 354 CYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 C ++A++ + C+ KC C LC CP I + Sbjct: 327 CL---YEALQLEDGIA--KCDGAKCFRCGLCYTRCPTCAISI 363 >UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria RepID=PYRD_DESAP Length = 307 Score = 107 bits (267), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 101/319 (31%), Positives = 154/319 (48%), Gaps = 22/319 (6%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 ++ G+ NP +S VG E G G +V KT+ A PR Sbjct: 6 AVAIAGLTLKNPVLTASGTVGFGEEYAPYLDLAGLGALVVKTVTLKPRAGNPPPRITETP 65 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA-RLVQ 124 +G +N E + + L L R D P +I SI GE ++ LA RL Sbjct: 66 AGVINAVGLQNPG--VEALVRDILPRLARF--DVP---VIVSIAGETVDEYARLAGRLDG 118 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 G +E N SCP + A G G P + R V+ + LP++AK++PN+ D+ Sbjct: 119 VPGIAALEVNISCPNV--KAGGIAFGTEPAMTAAVVRQVRENTRLPVIAKLSPNVTDIRT 176 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 +ALAA GAD ++ INT+ ++ ID+ ++ P++ + G SG AV+P+A+R + Q Sbjct: 177 IALAAAGAGADALSLINTLSAMV-IDVERR--RPLLG--NVFGGLSGPAVRPVAVRAVWQ 231 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV-TTGIMQYGYRIVEDMASGLSHY 303 + EL P+ G+GGI T DA EF+L GA + V T ++ G +A+ L Y Sbjct: 232 VYQAVEL---PLIGMGGIMTARDALEFILAGARAVAVGTANLVNPGA--AAAVAADLEQY 286 Query: 304 LADQGFDSLQEMVGLANNN 322 L +QG + E+VG A+ Sbjct: 287 LTEQGIRDINELVGAAHRT 305 >UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria RepID=PYRD_HELMI Length = 309 Score = 107 bits (267), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 92/326 (28%), Positives = 152/326 (46%), Gaps = 22/326 (6%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFK--TIGFFIANEVS 58 M + +L + G+ NP +S G E + G +V K T+ N + Sbjct: 1 MGSLNLQVNLGGLTMKNPVTTASGTFGFGLEFAPFIDLSRLGAIVVKGTTLEPREGNP-T 59 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 PR IG +N E + + L LR++ D +I ++ G + + + Sbjct: 60 PRMAETPAGMLNAIGLQNPG--VEAFIRDYLPPLRQI-----DTPVIVNVSGNSVEDYGR 112 Query: 119 LARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 LA ++ EA G +E N SCP + G G P RAV+ + P++ K++P Sbjct: 113 LASILDEADGVAALEVNISCPNVKEG--GIQFGTLPASAAAVTRAVRENTQKPVIVKLSP 170 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 N+ D+ E+A A GAD +A INT+ + +ID+ + P++ + G SG A+KP+ Sbjct: 171 NVTDITEMARAVVDAGADALALINTLLGM-DIDICTR--RPVL--ANIFGGLSGPAIKPV 225 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 ALR I Q+ + PI G+GGI +DA F+L GA + V T R D+ Sbjct: 226 ALRMIYQVYRAVHV---PILGMGGIMNSQDAIAFMLAGATAIAVGTANFT-NPRATMDIL 281 Query: 298 SGLSHYLADQGFDSLQEMVGLANNNI 323 G+ Y +G + E++G A++++ Sbjct: 282 EGIEEYCCREGVRDVNELIGAAHSHL 307 >UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomus RepID=B5YFH3_DICT6 Length = 306 Score = 106 bits (265), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 91/333 (27%), Positives = 160/333 (48%), Gaps = 38/333 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYD-TGWGGVVFKTIGFFIANEVSPRFDH 63 +L + + F NP L+S GN E+ K YD G GG V K+I ++PR + Sbjct: 3 NLEVRIGSLIFKNPILLASGTCGNGREI-NKFYDINGLGGFVTKSI------TLNPREGN 55 Query: 64 ----LVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + G + +E + + LEE + L RL + +I SI GE ++++ E Sbjct: 56 PPPRIWESYAGILNSIGLENVGLQKFLEEEMPFLERLSTN-----VIVSIAGEKKEEYYE 110 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 +AR ++ +E N SCP + M G E+V++ + V + P+ K+TP Sbjct: 111 IARNLRGCKISGVELNLSCPNVEGGGM--LFGIDKEMVKEITKKVVKEIGKPVWVKLTPQ 168 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 D+ E+ A K G + + NT + ID ++ P+ K +GYSG AVKP+ Sbjct: 169 AKDIVEIVKAVKDAGGEAVVLFNTFLGLA-IDWKKR--KPVF--KRIFAGYSGPAVKPLV 223 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ---YGYRIVED 295 LR++ ++ L PI G GGI ++ D E++ GA+ +Q+ + + G R+V++ Sbjct: 224 LRYVWEVYEENLL---PIVGCGGIVSFSDVLEYIFAGASLVQIGSANFRDPWIGERLVKE 280 Query: 296 MASGLSHYLADQGFDSLQEMVGLANNNIVPAED 328 ++ ++ D ++G+A+ N E+ Sbjct: 281 ---AFKYFEKERVMD----LIGIAHKNYKEVEE 306 >UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira RepID=PYRD_BRAHW Length = 303 Score = 106 bits (264), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 84/317 (26%), Positives = 155/317 (48%), Gaps = 22/317 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIANEVSPRFDHL 64 L+I F G + N SS G E + +D G V K G + + + + Sbjct: 4 LNINFLGKELKNNVITSSGCFG-FGEEYSNYFDVNELGAVNLK--GITLNKKDGNKGTRI 60 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + +G I +E ++N+ ++ +K P +I +I G ++ ++A + Sbjct: 61 AETPSGMINCIGLENPGIEYFKDNI--IKNIKYSTP---IILNINGATIDEYVKVAEIAN 115 Query: 125 EA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPMLAKMTPNIGDM 182 E D +E N SCP + + M G S E E +AVK+ S P++ K++PN+ D+ Sbjct: 116 EIERVDFVELNISCPNVKNGGMA--FGASCESAESTTKAVKKVLSKKPLIVKLSPNVTDI 173 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 +A A + GAD ++ +NT S + ++ K P++ + G SG ++PIA+R + Sbjct: 174 ASIAKAVEDAGADSVSLVNTFLS---MKIDTKTRKPLLG--NIFGGLSGACIRPIAVRMV 228 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 Q+ ++ PI G+GGI + DA EF+L GA+ + + GI +E + +G+ + Sbjct: 229 YQVYKAVKI---PIVGMGGITNYNDALEFILAGASLVSIGAGIFSNPILPIE-VINGIDN 284 Query: 303 YLADQGFDSLQEMVGLA 319 YL + ++++++G A Sbjct: 285 YLKENNISNIKDIIGAA 301 >UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria RepID=PYRD_GEOTN Length = 313 Score = 105 bits (263), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 89/290 (30%), Positives = 143/290 (49%), Gaps = 37/290 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIANEVSPRFDH- 63 L++ G+ NP +S G E A+ YD G ++ K A PRF + Sbjct: 4 LAVELPGLSLKNPIMPASGCFGFGREY-AQFYDLSVLGAIMIK------ATTKEPRFGNS 56 Query: 64 ---LVKEDTGF---IGFKN--MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 + + +G IG +N ++++ L E L L + D P +IA+I G ++ Sbjct: 57 TPRVAETPSGMLNAIGLQNPGLDKV----LAEELPWLEQF--DVP---IIANIAGSTMEE 107 Query: 116 WEELARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 + E+A + +A +E N SCP + G G PE+ + R VK S +P+ K Sbjct: 108 YVEVAAAISKAPNVHALELNISCPNVKKG--GIAFGTVPEVAAELTRLVKEVSAVPVYVK 165 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 ++PN+ D+ +A A ++ GADG+ INT + + ++ K G PI+ + G SG AV Sbjct: 166 LSPNVTDIVAMAKAIEQAGADGLTMINT---LVGMRIDVKTGRPIL--ANGTGGLSGPAV 220 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 KPIA+R I ++ + PI G+GG++T ED EF GA+ + V T Sbjct: 221 KPIAVRMIYEVS---QAVSIPIIGMGGVQTAEDVLEFFYAGASAVAVGTA 267 >UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PC95_9FIRM Length = 799 Score = 105 bits (262), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 89/342 (26%), Positives = 155/342 (45%), Gaps = 24/342 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 + + GV F NPF ++S P + +TGW K + A ++ + + + Sbjct: 7 IPVKVGGVTFKNPFYVASGPTTKNVRQLQRIEETGWAAASIK-LSIDPAPYINRKPRYGL 65 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ---WEELARL 122 ++T + F +++ +E L + K+ D +L+A+I ++ W +A+ Sbjct: 66 FDETNALAFTAEKRLT---FQEGLTLIEDAKKVLSDLILMANITYAGDRGAAGWVNMAKQ 122 Query: 123 VQEAGADMIECNFSCPQM-------------TSHAMGSDVGQSPELVEKYCRAVKRGSTL 169 + GAD+IE N CP M TS G+ +G+ +V + RA+K+ + Sbjct: 123 FEAVGADIIELNMCCPNMSYNVSLSSGGAASTSQQTGASLGRQAGVVAEIVRAIKKEIHI 182 Query: 170 PMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI--VNGKSSIS 227 P+ K+TP G++ +VA A GAD + + + IDLN G + + + S+S Sbjct: 183 PLFVKLTPEGGEVAQVAAALYAAGADAVGSTGNRLGLPPIDLNDP-GRAVYHLQDEISMS 241 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 Y G +KP+A R ++R + + + GGI W A E +L G L V + Sbjct: 242 CYCGSWLKPLAQRDAYEIRKVCGM-EPKMMAAGGITDWRSAVEMVLCGGNLLGVCAETLI 300 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDL 329 GY IV M GL Y+ G+ S+ + G + + A +L Sbjct: 301 SGYDIVRPMIRGLKDYMDTHGYRSIDDFCGKVVSAVRTAPEL 342 >UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_THEYD Length = 303 Score = 103 bits (256), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 82/314 (26%), Positives = 146/314 (46%), Gaps = 20/314 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L + + F NP +S G E GG+V K + P + Sbjct: 4 LEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPP--PRIY 61 Query: 66 KEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + G I ++ I E +E L L++ + +I + GEN ++ E+A+L+ Sbjct: 62 ETPCGMINSIGLQNIGLEAFKKEKLPFLKKFNTN-----IIVNFFGENLDEYIEVAKLLD 116 Query: 125 EA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 E G +E N SCP TS +G PEL+ + + V+ P++ K+ P + ++ Sbjct: 117 ETEGVHALEMNVSCPNKTSE--WRKMGLEPELLREAIKRVRLHIKKPLIVKLAPQVTEIA 174 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +A + GAD ++ INT+ ++ ID+ + M + G SG A++P+ALR + Sbjct: 175 LMARICEEEGADAVSLINTIPAMV-IDIKTRKSMI----GTLTGGLSGPAIRPVALRAVW 229 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ ++ P+ G+GGI + EDA +FL+ GA +QV T VE + G+ + Sbjct: 230 EVAQAVKI---PVIGVGGIVSAEDALQFLIAGAKAIQVGTANFINPIATVE-IIEGIKQF 285 Query: 304 LADQGFDSLQEMVG 317 L ++ + E++G Sbjct: 286 LIEENIKDINEIIG 299 >UniRef50_A9MK69 Putative uncharacterized protein n=1 Tax=Salmonella enterica subsp. arizonae serovar 62:z4,z23:-- RepID=A9MK69_SALAR Length = 71 Score = 102 bits (254), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 53/96 (55%), Positives = 59/96 (61%), Gaps = 34/96 (35%) Query: 316 VGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNT 375 +GLANNNI+PAEDLDRSYIVYP+IN Sbjct: 10 IGLANNNIIPAEDLDRSYIVYPQIN----------------------------------Q 35 Query: 376 EKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 EKCVGCLLCGHVCPV CI+LGEV+FKKGEKEH +TL Sbjct: 36 EKCVGCLLCGHVCPVACIDLGEVRFKKGEKEHALTL 71 >UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G037_9DELT Length = 334 Score = 101 bits (252), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 80/282 (28%), Positives = 135/282 (47%), Gaps = 27/282 (9%) Query: 46 FKTIGFFIANEVSPRFDH------LVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKED 98 + IG +SP H + + +G I +E + E L E L L L Sbjct: 50 LRQIGGLSTKGISPLPRHGNPLPRIYETASGMINSIGLENVGCEAFLTEKLPFLADL--- 106 Query: 99 YPDKVLIASIMGENEQQWEELARLVQEAGA---DMIECNFSCPQMTSHAMGSDVGQSPEL 155 D + + G + + + + A+ + E G D++E N SCP + G + G PE+ Sbjct: 107 --DVSVWVNFFGTDFETYVDCAKTLSEGGEGRIDVLEMNISCPNIKKG--GIEFGTVPEV 162 Query: 156 VEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 + +A S +P++ K+TPN+ D+ +A A K GA G++ INT+ ++ ID+ + Sbjct: 163 AHRLTKACVEASEVPIVVKLTPNVSDIVAMAQAVKEAGAIGVSLINTITAMA-IDVRSRR 221 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 ++ G SG A+KP+ALR + Q+ L FPI G+GGI T ED E+ + G Sbjct: 222 S----RIATTYGGLSGPAIKPVALRMVHQVAK--ALPGFPICGMGGILTGEDVLEYFIAG 275 Query: 276 AATLQV-TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMV 316 A +Q+ T + G + + L +A+ G + +Q+ V Sbjct: 276 AHCVQLGTINFSEPGAAL--RVTRELRELMAELGIERVQDAV 315 >UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=B7RZ94_9GAMM Length = 552 Score = 101 bits (251), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 65/197 (32%), Positives = 106/197 (53%), Gaps = 15/197 (7%) Query: 89 LAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSD 148 L A R+ ED + L+ SI G + ++ E+A+++ +D +E N SCP + M Sbjct: 97 LMAQLRVPED---RFLLTSIFGGSIDEFVEVAKILAPV-SDGLELNLSCPHAKGYGMA-- 150 Query: 149 VGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITN 208 +GQ P++V + AVK +P++ K+TPN D+ +A AA+ GGADG AINTV Sbjct: 151 MGQDPDMVREIVAAVKAVVDIPVIPKLTPNTPDITVIARAAEAGGADGFCAINTVGP--- 207 Query: 209 IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDA 268 G P+++ + G SGK + PI L+ ++++ E+ D PI G GG+ + +D Sbjct: 208 -GYTSAHGHPVLSNGA--GGMSGKGILPIGLKCVKEVA---EVSDLPIIGCGGVSSADDV 261 Query: 269 AEFLLLGAATLQVTTGI 285 F GA + V + + Sbjct: 262 RAFFDAGAEIVGVGSAL 278 >UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidales RepID=PYRD_BACV8 Length = 303 Score = 100 bits (250), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 84/318 (26%), Positives = 155/318 (48%), Gaps = 26/318 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS+ +K NP +S G E GG++ K G + + + + Sbjct: 3 DLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVK--GTTLHHREGNPYPRM 60 Query: 65 VKEDTGF---IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + G +G +N + ++ +E +R + + +I ++ G + + + A Sbjct: 61 AETPMGMLNAVGLQN--KGVDYFVEHIYPQIRDIHTN-----MIVNVSGSAVEDYVKTAE 113 Query: 122 LVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ + IE N SCP + M G S + +AV+ ++ K++PN+ Sbjct: 114 IINDLDHIPAIELNISCPNVKQGGMA--FGVSACGCSEVVKAVRNVYKKTLIVKLSPNVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG-YSGKAVKPIAL 239 D+ E+A AA+ GAD ++ INT+ + +D ++ P++ S+I+G SG AVKPIAL Sbjct: 172 DITEIARAAEASGADSVSLINTLLGMA-VDAEKR--RPVL---STITGGMSGAAVKPIAL 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ + + P+ G+GGI W+DA EF+L GA +Q+ T I ++ G Sbjct: 226 RMVWQV---AKAVNIPVIGLGGIMGWKDAVEFMLAGATAIQIGTANF-IDPAITVKVSEG 281 Query: 300 LSHYLADQGFDSLQEMVG 317 ++ YL G+ S+++++G Sbjct: 282 INDYLERHGYTSVKDIIG 299 >UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteobacteria RepID=Q1MQG1_LAWIP Length = 314 Score = 100 bits (250), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 70/217 (32%), Positives = 117/217 (53%), Gaps = 20/217 (9%) Query: 104 LIASIMGENEQQWEEL-ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 +IA++ + +++ EL A L E G +E N SCP + S G+ GQ P L K A Sbjct: 105 VIANLYATSVEEFSELTAILAAEEGVAALEVNVSCPNVKSG--GTFFGQDPSLAAKVTEA 162 Query: 163 V-KRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVN 221 V K + P++ K++PN+ D+ +A A + GAD I+ INT+ + +D+ ++ + Sbjct: 163 VCKNAGSKPVMVKLSPNVTDITIIAKAVESAGADAISCINTLTGMA-VDIRKRKSLL--- 218 Query: 222 GKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 + I G SG +KPIALR + ++ + + P+ GIGGI + D EF+L+GA +Q+ Sbjct: 219 -STVIGGLSGPGIKPIALRCVWEVC---KAVNIPVIGIGGITSARDVLEFILVGAHAVQI 274 Query: 282 TTGIMQY-----GYRIVEDMASGLSHYLADQGFDSLQ 313 G M + +RI E + + + L + FDS + Sbjct: 275 --GTMNFIQPDIAFRIAEALPI-ICNELGIKNFDSFR 308 >UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer subunit/dihydroorotate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JFH0_9ARCH Length = 589 Score = 100 bits (250), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 85/325 (26%), Positives = 152/325 (46%), Gaps = 30/325 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEV-SPRFDH 63 +L+ CG+ F NP +++ G ++ + G G VV K++G + +P F Sbjct: 288 ELATEVCGIIFTNPIA-NAAGFGLSGKLLYRYAVAGAGAVVTKSVGLYEQEGYPNPTFIE 346 Query: 64 LV-KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + + +G N I ++ LE A Y D LI SI G+N ++ E+A++ Sbjct: 347 IAPRSYVNAMGLPN-PGIIDYGLEIGDA-------KYADVPLILSIFGKNVEECREVAKI 398 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAKMTPNIGD 181 + DM+E N SCP H+ V P+L+ + ++ P+ K++PN+GD Sbjct: 399 ATKYPIDMLEFNASCP----HSDFVAVENQPKLLRSIIKEIRAIVHPKPIAVKISPNVGD 454 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV----KPI 237 +A+ ++ GAD I AINTV + ++ ++ I+ + G SGK + K I Sbjct: 455 PAGLAMTLEKAGADAITAINTVIARP---VDNRLDTHILGNPTGYGGKSGKDLTVGGKEI 511 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 ++++ PI +GGI + +D ++ GA+ QV + ++ I + Sbjct: 512 VFNLYKELK-------IPIIAVGGIFSAKDVIDYAKNGASMFQVGSALVSEDLEIFSTIK 564 Query: 298 SGLSHYLADQGFDSLQEMVGLANNN 322 L YL +G+ ++ EMVG A+ Sbjct: 565 KELKAYLGAKGYKNIGEMVGEAHRR 589 >UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit n=5 Tax=Clostridium difficile RepID=C9XJU2_CLODC Length = 361 Score = 99.4 bits (246), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 98/380 (25%), Positives = 172/380 (45%), Gaps = 37/380 (9%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 F G + +P + S P+ C D G G VV KTI A +P H+V+ + Sbjct: 3 NFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIRKERAINPAP---HMVR-N 58 Query: 69 TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGA 128 T N + P + + ++K D V IAS+ G ++ EL V AGA Sbjct: 59 TANALLNNEKWTDFEPEQWIDFEIPQMKRD--GTVCIASV-GHTIEESSELVEKVANAGA 115 Query: 129 DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALA 188 D IE + S+ + P L + K +P++ K+ P I ++ + A Sbjct: 116 DFIE-------LVSYDYRDLI---PML-----KDAKERVNIPVIVKLPPMIDEIGDFAKK 160 Query: 189 AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH 248 + GAD I A ++V ID+ + G P++ G + I SG+ +KPI L+ I +++ Sbjct: 161 LEEAGADAITACDSVGPAFRIDI--ETGQPLLGG-NGIGYLSGETIKPITLQRIYEIKKQ 217 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 + PI G+GG + +DA E ++ GA + + + ++ G +++ + L L G Sbjct: 218 V---NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRLG 274 Query: 309 FDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKT 368 +++++ G+ +N++ D++ + +KC C C C +QA + ++K Sbjct: 275 YNTIENACGIVHNHM---GDVNERLSFEFTYDEEKCTKCKMCERVC---AYQARKLNDKM 328 Query: 369 RTPHCNTEKCVGCLLCGHVC 388 N E+C C LC VC Sbjct: 329 EL---NEEECRYCGLCISVC 345 >UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria RepID=PYRD_PETMO Length = 300 Score = 99.4 bits (246), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 82/323 (25%), Positives = 144/323 (44%), Gaps = 35/323 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTI---------GFFIAN 55 D + GV+F NP +S G E + GG+ K + G I Sbjct: 3 DTKVNIAGVEFKNPVIAASGTFGFGREFLEYFPISKLGGLATKGLTLREREGNKGVRIHE 62 Query: 56 EVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 + + + ++ G F +EE L L + D V+IA++ G + Sbjct: 63 TIGGIMNSIGLQNPGIDAF----------IEEELPFL-----NSQDTVIIANVSGNTIDE 107 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 + + + DMIE N SCP + G G E+ V++ P++ K+ Sbjct: 108 YVISVEKLNQTDIDMIELNISCPNVKEG--GISFGTKAEIASNVVTQVRKVCQKPLIVKL 165 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 +P+ ++ E+A + GAD ++ +NT ++ ID+++K + + +G SG +K Sbjct: 166 SPSAENIVEMAESCVEAGADALSLVNTFPALA-IDISKKKAI----FDNITAGLSGPCIK 220 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 PIALR + ++ + D PI GIGGI + DA E+++ GA +QV T + Sbjct: 221 PIALRMVYEVS---KAVDVPIIGIGGIMDYRDAIEYIMAGAWAVQVGTANF-INPNACAE 276 Query: 296 MASGLSHYLADQGFDSLQEMVGL 318 + G+ YL +G +L+E+ G+ Sbjct: 277 IIEGIEEYLQKEGISTLEEIRGI 299 >UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10 Tax=Proteobacteria RepID=Q3J7C7_NITOC Length = 331 Score = 99.4 bits (246), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 91/321 (28%), Positives = 145/321 (45%), Gaps = 30/321 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVG--NCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 L + FCG++ +P L S VG Y + G V K G A + Sbjct: 17 LKVDFCGLELQSPLVLLSGCVGFGEEYTRVVGFSNREVGAVCLK--GTTAAPRLGNALHR 74 Query: 64 LVKEDTGF---IGFKN--MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + G IG +N ++ + +H L AL D+ + IA++ G +++ Sbjct: 75 IYETPMGMLNAIGLQNPGVDYVVDHILP----AL-----DFSETRYIANVSGSTIEEYTA 125 Query: 119 LARLVQEAGADMIECNFSCPQMTSH--AMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 + R + D IE N SCP + A G+D S +VE CR V R P++ K++ Sbjct: 126 VTRRFDNSPIDAIEINISCPNVKEGGVAFGNDPHMSARVVEA-CRKVTRK---PLITKLS 181 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 PN + E A G DG A INT+ + ID+ Q+ P++ G SG A+KP Sbjct: 182 PNQTSIEENARRCIEAGTDGFAVINTLMGMA-IDIEQR--TPLLGNIQG--GLSGPAIKP 236 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 IAL ++Q+ PI G GG+ + +DA EFL+ GA T+ V T + Y + + Sbjct: 237 IALLKVRQVYQACRAHGIPIIGQGGVASGKDALEFLIAGATTVGVGTALF-YDPLLCAKI 295 Query: 297 ASGLSHYLADQGFDSLQEMVG 317 + + YL ++ ++ G Sbjct: 296 NAEIVAYLKRHDLRAVAQLTG 316 >UniRef50_UPI00019039D0 dihydropyrimidine dehydrogenase n=2 Tax=Rhizobium etli RepID=UPI00019039D0 Length = 179 Score = 99.0 bits (245), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 51/130 (39%), Positives = 79/130 (60%), Gaps = 2/130 (1%) Query: 271 FLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 L+LGA +QV T M YG++IV++M SGLS ++ ++G +L ++ G A N+ + L+ Sbjct: 16 ILVLGAGNVQVCTAAMTYGFKIVDEMISGLSDWMDEKGHRTLDDITGRAVPNVTDWQYLN 75 Query: 331 RSYIVYPRINLDKCVGCGRCYISCYDGGHQAM-EWSEKTRTPHCNTEKCVGCLLCGHVCP 389 +Y+ +I+ D C+ CGRC+I+C D HQA+ R E+CVGC LC VCP Sbjct: 76 LNYVAKAKIDQDACIKCGRCHIACEDTSHQAITNVVNGLRHFEVIDEECVGCNLCVSVCP 135 Query: 390 V-GCIELGEV 398 V CI + ++ Sbjct: 136 VENCITMEQL 145 >UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12 Tax=Chlorobiaceae RepID=Q3B2I1_PELLD Length = 331 Score = 97.4 bits (241), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 81/309 (26%), Positives = 150/309 (48%), Gaps = 22/309 (7%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGF 71 G+ +P L+S V E+C + GG+V K I P+ + + +G Sbjct: 37 GLSLKSPVMLASGTVSYGEELCRLTDLSKIGGIVTKAISLEARAGNPPQ--RIAETPSGM 94 Query: 72 IGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL-ARLVQEAGAD 129 I + + + + E + L+ L ++ +I G + ++ E+ +RL G D Sbjct: 95 INAIGLANVGIDRFISEKVPFLQTL-----GTAIVVNIAGRSIDEYAEVVSRLDAVPGLD 149 Query: 130 MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAA 189 E N SCP + M +G SP+ + ++ + ++ K+TPN+ + +A+AA Sbjct: 150 GYEINLSCPNVKGECM--IMGVSPDATREIVTELRSITGRHLMIKLTPNVTSISAIAIAA 207 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 ++ GAD ++ INT+ + ID ++ P++ K+ G SG A+KP+AL + ++ Sbjct: 208 EKAGADSVSLINTLVGMA-IDWKKR--RPLL--KNVTGGLSGPAIKPVALAKVWEVNNAV 262 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY-RIVEDMASGLSHYLADQG 308 + PI G+GGI +++DA EFL+ GA +Q+ G M + I E +A+ + + G Sbjct: 263 SI---PIVGMGGIASFDDAMEFLVAGAGAVQI--GTMNFVQPDIGEKIATAMEAFFCAPG 317 Query: 309 FDSLQEMVG 317 S++ G Sbjct: 318 APSMEAFRG 326 >UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding protein n=5 Tax=unclassified Gammaproteobacteria RepID=A0Z3E6_9GAMM Length = 551 Score = 97.4 bits (241), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 71/235 (30%), Positives = 120/235 (51%), Gaps = 13/235 (5%) Query: 74 FKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIEC 133 F N + +LA+L +L+ D+ L+ SI G + +++ +A++++ AD E Sbjct: 67 FVNAVGLTNPGAHASLASLGQLRVPE-DRFLLVSIFGGSVEEFVAVAKILEPV-ADGFEL 124 Query: 134 NFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGG 193 N SCP + + M +GQ P++V + AVK+ + P++ K+TPN+ ++ E+ AA G Sbjct: 125 NLSCPHASGYGMA--MGQDPKIVHEIIAAVKQVVSKPVIPKLTPNVTNIAEIGQAALDAG 182 Query: 194 ADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRD 253 ADG+ AINTV + + + NG + G SGK V P AL+ I+++R + D Sbjct: 183 ADGLCAINTVGPGYTESHGEAV---LSNG---VGGMSGKGVLPTALKCIRELRA---ITD 233 Query: 254 FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 PI G GG+ + D GA + + + + ++ S LS L QG Sbjct: 234 KPIIGCGGLSSAADVNAAKHAGATIVGIGSALSGMDTEDLQRYFSTLSKDLDRQG 288 >UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=PYRD_CARHZ Length = 307 Score = 97.1 bits (240), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 124/226 (54%), Gaps = 22/226 (9%) Query: 101 DKVLIASIMGENEQQWEELARLVQEAGA-DMIECNFSCPQMTSH--AMGSDVGQSPELVE 157 + +LI +I GE+ ++++ LAR Q +E N SCP ++ A G+D+ E ++ Sbjct: 92 NDILILNIAGESVEEFQYLAREAQRFDEIKALELNVSCPNVSKGGIAFGTDL----EALK 147 Query: 158 KYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGM 217 + +V++ + ++ K+TPN+ D+ A AA+ GAD + INT + ID+ K Sbjct: 148 QIVSSVRKIYSKTLIVKLTPNVTDITVYAKAAENAGADALTLINTFTGMV-IDVKSK--K 204 Query: 218 PIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAA 277 PI+ K G SG A++P+A++ + + PI G+GGI++ E A EF L GA Sbjct: 205 PILGNKH--GGVSGPAIRPMAVKMVYDCFKAVSI---PIIGVGGIDSKEAALEFFLAGAT 259 Query: 278 TLQV-TTGIMQYGY--RIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 +QV + ++ G+ R++ + L YL ++ +S+ ++ GLA+ Sbjct: 260 AIQVGSQNFVEPGFMPRLIRE----LGEYLQEENIESIAKLTGLAH 301 >UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyrus kandleri RepID=Q8TXU6_METKA Length = 318 Score = 95.5 bits (236), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 74/221 (33%), Positives = 111/221 (50%), Gaps = 12/221 (5%) Query: 101 DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC 160 D + AS+ + + ++ LAR AD +E N SCP G+++G PE V + Sbjct: 93 DVPVYASVAADGPEGFKRLARAFSGV-ADGLELNVSCPH-AGKGYGAELGSDPEAVAEIT 150 Query: 161 RAVKRGSTLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMP 218 A R P+ K+TPN+ + EVA AA GA+ + A+NT+ IDL + P Sbjct: 151 EAAVRAFDGPVSVKLTPNVDRETLLEVAAAAIDAGAEALTAVNTLGPGLRIDL--RTASP 208 Query: 219 IVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAAT 278 ++ + + G SG A+KPIALR + + + I G+GGI ED EFL GA Sbjct: 209 VLG--AGVGGLSGPALKPIALRVVADLALEFG-EEVEIIGVGGIRNGEDVVEFLFAGAKA 265 Query: 279 LQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 +QV T + + D+A SH L + G+D +E +G A Sbjct: 266 VQVATAAREKDFG---DIAMETSHILKELGYDGPEEAIGAA 303 >UniRef50_A8RT96 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RT96_9CLOT Length = 361 Score = 95.5 bits (236), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 97/371 (26%), Positives = 164/371 (44%), Gaps = 50/371 (13%) Query: 35 KAYDTGWGGVVFKTIGFFIANEVSPRFDHL--VKEDTGFIGFKNMEQIAEHPLEENLAAL 92 K ++ G G VV KTI A ++P H+ V +D+ N E+ A+ L Sbjct: 3 KGHEAGAGAVVTKTIRLGAA--INP-VHHMGTVNQDS----LINCEKWADSD------RL 49 Query: 93 RRLKEDYPDKVLIASIM----GENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSD 148 + + P V +++ G ++ + + + V+ AGA MIE Sbjct: 50 NWYENEIPKTVAAGAVVIGSVGHTLKEAQAIVKDVERAGAHMIEL--------------- 94 Query: 149 VGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITN 208 V + + + K +P++ K++ N D A GA+GI AI+++ Sbjct: 95 VSYTEDTLLPMLDYTKEHVDIPVICKLSGNWPDTAATARRCLEHGANGICAIDSIGPTLK 154 Query: 209 IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM-RTHPELRDFPISGIGGIETWED 267 ID+ + P + +G A++PIA+R+ Q+ + +P+L + SG G+ +D Sbjct: 155 IDIEK--AAPEMMSGDGFGWMTGAAMRPIAMRYNYQIAKENPQLMNLYASG--GVMKADD 210 Query: 268 AAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 A E+++ GA + V T + G VE M LS LA+ G+ S+QE+ A+ N E Sbjct: 211 AIEYMMAGAMGVGVCTAGILKGVEYVEKMCYDLSKRLAELGYSSIQEVNRAAHPNFPSEE 270 Query: 328 DLDRSYIVYPRINLD----KCVGCGRC-YISCYDGGHQAMEWSEKTRTPHCNTEKCVGCL 382 + + D KCV C +C + CYD + + + E T + +KC C Sbjct: 271 HISGLKFHFTPFKEDGTTKKCVSCKKCETVCCYDA--RKLTFPEMT----VDMDKCRCCG 324 Query: 383 LCGHVCPVGCI 393 LC VCP G + Sbjct: 325 LCLDVCPTGAL 335 >UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Staphylothermus marinus F1 RepID=A3DM44_STAMF Length = 301 Score = 95.1 bits (235), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 83/325 (25%), Positives = 146/325 (44%), Gaps = 36/325 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DL+ G+ F +P +S + + TG G+V KT+ + PR +L Sbjct: 2 DLTTKVTGIVFKHPIMNASGILASSINGVGILAKTGVAGIVTKTL------TLKPREGYL 55 Query: 65 ----VKEDTGF---IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 + D G +G N A + L E + K P I SI G + ++++ Sbjct: 56 PPITIPLDYGLLNAVGLANPGIDAVNVLVEEIH-----KYGLPA---IVSIGGRDPREFQ 107 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM-- 175 LA +A + +E N SCP + G D + E+++ V S +P+ K+ Sbjct: 108 ILAEKALDARPEALELNLSCPH--TPGFGVDTVATDEVLKHVALNVSSVSNIPVWGKLGF 165 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 + I E+ L G D + INT+ + ++ +G P++ G SG A+ Sbjct: 166 SRRIIRESEILL---NNGVDAVVLINTLPGMF---IDVYVGKPVLT--HGFGGLSGPAIH 217 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 P+A+ + ++ E I G+GG+ W+ + E LL GA +Q+ TG GY IV + Sbjct: 218 PVAVYSVYKVY---EELGAEIIGVGGVIDWKTSVELLLAGAKAIQIGTGFYMVGYNIVNN 274 Query: 296 MASGLSHYLADQGFDSLQEMVGLAN 320 + G+ Y+ ++GF + +++G A+ Sbjct: 275 ILDGIKKYMEEKGFTRISDIIGYAH 299 >UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding n=1 Tax=Treponema denticola RepID=Q73P17_TREDE Length = 591 Score = 92.4 bits (228), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 67/202 (33%), Positives = 102/202 (50%), Gaps = 10/202 (4%) Query: 85 LEENLAALRRLKEDYP-DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSH 143 +E+ + L+ L+ + D +L S+ N + + L + +E AD E NFSCP S Sbjct: 90 MEQAVKELKELRSSWKTDSILNVSLSASNPEDFISLLKGFEEL-ADCFELNFSCPH-ASA 147 Query: 144 AMGSDVGQSPELVEKYCRAVKRG---STLPMLAKMTPNIGDMCEVALAAKRGGADGIAAI 200 G+ +G P + +Y + +K+ +P+ K+TPN+ D+ +A A GADGI AI Sbjct: 148 GFGASIGCDPAIAAEYVKIIKKALPDCAVPIFVKLTPNVEDIGAIASAVIEAGADGITAI 207 Query: 201 NTVKSITNIDLNQKIGMPIVNGK-SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGI 259 NTV I+ + G PI+ K G SG V P AL I Q+R + PI G+ Sbjct: 208 NTVGPKVYIEPHS--GKPILQNKLGGKGGMSGAWVFPRALECIGQIRKAVG-EEIPIIGM 264 Query: 260 GGIETWEDAAEFLLLGAATLQV 281 GG+ T AAE + GA + + Sbjct: 265 GGVMTGAQAAELVRAGADIIGI 286 >UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae RepID=C9M6H2_9BACT Length = 317 Score = 91.7 bits (226), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 66/209 (31%), Positives = 101/209 (48%), Gaps = 31/209 (14%) Query: 129 DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALA 188 D +E N SCP + M G P L + + V+R + P+ K+TP D C VA A Sbjct: 126 DCVELNVSCPNVDQGCM--SWGVDPALTAQAVQQVRRRWSGPLWVKLTPQAPDPCAVAKA 183 Query: 189 AKRGGADGI--------AAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 A+ GA + AAI+TVK+ D ++G SG A+ P+ALR Sbjct: 184 AQDAGASALVVANTWLGAAIDTVKARPAFD-------------RVVAGLSGPAIFPLALR 230 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q+ D P+ G GG+ + + A L+ GAA ++V + + ++E +A GL Sbjct: 231 MVWQVCGA---VDIPVVGCGGVASADSAVAMLMAGAAAVEVGMALFS-DFSVLERIARGL 286 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDL 329 ++ +GF S+ E+VGLA P DL Sbjct: 287 EEEVSRRGFQSVGELVGLAR----PDRDL 311 >UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5E1_CHRVI Length = 338 Score = 90.5 bits (223), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 88/336 (26%), Positives = 151/336 (44%), Gaps = 39/336 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTI---GFFIANEVSPRF 61 +L T+ G+ NP S+SP+ + D+G +V ++ E RF Sbjct: 2 NLKTTYLGLTLKNPLVPSASPLSRSLSAAREMEDSGAAAIVMYSLFEEAITAEAESMTRF 61 Query: 62 DHLVKEDTGFI----GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 H +DTGF GF Q E+ LE L +RRLKE D +IAS+ G W Sbjct: 62 LH--HQDTGFAESSAGFLPDHQDFENGLERYLEQIRRLKESL-DIPVIASLNGVTTGGWV 118 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVE-KYCRAVK--RGST-LPMLA 173 + A +Q+AGAD +E N + + D+ Q+ VE +Y + RG +P+ Sbjct: 119 KHALELQQAGADALELNV-------YYIAGDISQNGAQVEQRYLDLLTELRGRIRIPINM 171 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVK----SITNIDLNQKIGMPIVNGKSSISGY 229 K++P+ + GA+G++ N +I ++ L ++ P Sbjct: 172 KLSPSFSSIGHFVGRLAAAGANGVSLFNRFYQPDINIDSLRLQARL-HP----------- 219 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 S A +A+R+I + + + + GGI T EDA + LL GA + + + ++Q G Sbjct: 220 STSAEALLAMRWIALL--YGRVPGLSLGATGGIHTSEDAIKLLLAGADVVHLCSVLLQKG 277 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVP 325 + G++ ++ +QGF+S+++ G + VP Sbjct: 278 PVYTGLILRGIADWMEEQGFESVEDFRGRVSALTVP 313 >UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family protein n=1 Tax=uncultured actinobacterium RepID=D0U5Z4_9ACTN Length = 324 Score = 90.1 bits (222), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 90/332 (27%), Positives = 149/332 (44%), Gaps = 40/332 (12%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 D S+ V+F +P L+S G+ E+ + G +V K++ F A +PR Sbjct: 8 DHSVRVDDVEFKSPVLLASGTAGHADELEPYFPLSKIGAIVVKSMSSFEWAGNKAPR--- 64 Query: 64 LVKEDTGFIGFKNMEQI-AEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L + G + ++ + H +E +L L+++K ++ASI G + + A L Sbjct: 65 LRPTNGGMLNAVGLQGLGVAHWIEHDLPRLKKVKA-----TIVASIWGFSIDDYRSAASL 119 Query: 123 VQEAGADM--IECNFSCPQMTSHAMGS---------DVGQSPELVEKYCRAVKRGSTLPM 171 + E D+ IE N SCP + S + + D S E+V + C K +P+ Sbjct: 120 LSEVSTDLAAIEINLSCPNIGSSSKAANTPHGIFAHDEDLSAEIV-RVCSVAK----VPL 174 Query: 172 LAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 AK++PN + +VA A + G + INT + L + + + G SG Sbjct: 175 WAKLSPNTDRVVDVAAAVSKAGCQAVTLINTA-----LGLAIDVETGLPALGNGGGGLSG 229 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM---QY 288 + PIA+R I +RT L PI G+GGI EDA E ++ GA+ +QV T + Sbjct: 230 SGIHPIAVRTIFDVRT--RLPRLPIIGVGGIANGEDAIEMMMAGASCIQVGTATFADPRA 287 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 RI +M + G ++ E+V A+ Sbjct: 288 AMRIDREM----RQWARKHGVNNWSEVVNAAH 315 >UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8W8_WEIPA Length = 323 Score = 89.0 bits (219), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 80/325 (24%), Positives = 149/325 (45%), Gaps = 30/325 (9%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH--- 63 +++ G+K NPF SS + G +V KT ++PR + Sbjct: 7 AVSLPGLKLKNPFMPSSGAFYYGLDHMDDFDLNKLGALVLKT------TTLAPRTGNPQP 60 Query: 64 -LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 +V G + + ++ + L L PD + SI G ++ +LA++ Sbjct: 61 WIVNTKAGILNSVGLANPGIAAVKADF--LPELAAKLPDLPKMLSISGATVDEFVQLAKI 118 Query: 123 VQEAGA-DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + + A + IE N SCP + G G + + AV+ +T + AK++PN+ D Sbjct: 119 IDKLPAINAIELNLSCPNVDEG--GCAFGVTESGIHSVVSAVRAVTTKAIYAKLSPNVTD 176 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + +A+ A+ GADG+ +NT+ ++ +DL + + GK G SG+A+ P+A+ Sbjct: 177 IKPLAVTAENAGADGLTMVNTLVGMS-LDLQSRSAR-LYRGK---GGLSGEALHPLAVEL 231 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY-----GYRIVEDM 296 I + + + PI G+GG+ + +DA E ++ GA+ +QV G+M ++++ + Sbjct: 232 IWEAASAVHI---PIIGVGGVSSIDDALELMMAGASAVQV--GVMNSIDKLCLPKLIDAL 286 Query: 297 ASGLSHYLADQGFDSLQEMVGLANN 321 + L Y D+ D + L N Sbjct: 287 PAALDKYHFDKVSDVTNALRALPEN 311 >UniRef50_C4T7U5 Dihydropyrimidine dehydrogenase n=1 Tax=Yersinia intermedia ATCC 29909 RepID=C4T7U5_YERIN Length = 397 Score = 88.6 bits (218), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 96/415 (23%), Positives = 179/415 (43%), Gaps = 45/415 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS--- 58 +++ L + F G K +P + + P +A G G + K+IG+ E + Sbjct: 4 MSQRLFVDFMGKKLCSPIIVGAGPSTKSCSDIIEAAKFGAGAAIIKSIGWHADVEKTLKD 63 Query: 59 -PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP--DKVLIASIMGENE-Q 114 R+ +K ++ + +I P NL + D P V ++ E++ Sbjct: 64 RKRY-RWIKGYGTYLKSTYLCEILSKPYGCNLIKEVKSSSDIPIYASVFYPALSNEHDID 122 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 +W +L V AG D ++ +F + +V + + + CR+ + LP++ K Sbjct: 123 RWIDLVSEVSNAGCDGVQLDFFYLDL-RKLNDDEVCFFVDAINRICRS----THLPVMPK 177 Query: 175 MTPNIGD-MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK-------SSI 226 + + D + E L K +D I+++ + ID+ K G P+ +G+ S Sbjct: 178 LNIAMDDDLIENLL--KNSLSDAYVFIDSINTEPYIDIWNK-GAPLFDGQLYNSQTNRSG 234 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 S +G+A+ P Q++ D +S GG+E WED ++LGA+T+ +T+ +M Sbjct: 235 SVVAGEALLPFTFNMTQRLYRST---DKNLSAGGGLEHWEDIIRCIMLGASTVHLTSILM 291 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGL-----ANNNIVPAED-LDRSYIVYPRIN 340 + G++ + D+ S +++YL Q + + ++ G+ A N I+ + LD I I+ Sbjct: 292 RRGFKYIRDLNSSINNYLDKQHVEKISDIRGVSYSTNAGNTIIQQKPILDMRAI----ID 347 Query: 341 LDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 KC CG C + + P+ C GC C +CP I L Sbjct: 348 SSKCNDCGVC--------ERFKVCDSFSVKPYDFINNCDGCTYCLALCPRNAISL 394 >UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Clostridium botulinum RepID=C3KS38_CLOB6 Length = 298 Score = 88.2 bits (217), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 83/305 (27%), Positives = 139/305 (45%), Gaps = 29/305 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L G+K NP ++SS + + + K D G G V+ KTI N S R L Sbjct: 10 LQTEVLGMKLKNPVIIASSNLTDNEKSIRKFLDLGVGAVITKTIYIGEKNIQSGRI--LR 67 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRL-KEDYPDKVLIASIMGENEQQWEELARLVQ 124 KE F N ++ + E L +L KE+ P +I SI+ + + + LA ++ Sbjct: 68 KESQIF----NSTTYSKKSISEWTEILSKLYKENLP---VIPSIVADTKDELVNLALQME 120 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 E G +E SCP +++G + E + + RAV R ++P+ K+T + + Sbjct: 121 EVGCKALELGISCP--------NEIGIN-EKIYDFTRAVCREVSVPVSVKLTSEV----K 167 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 V ++ G +++ SI I +N +P+ GYSG A+KPI + I Sbjct: 168 VEEKVRKAMCAGAKSVSISDSIPAIVVNTDGTLPL----GVRCGYSGPAIKPIVQKNIYY 223 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 ++ + D + GIGGIE D E+L +G++ +++ + I G VE + L + Sbjct: 224 LKKNNA--DVEVIGIGGIENANDVLEYLYVGSSAVELCSCIFINGINQVERIIHDLKNMF 281 Query: 305 ADQGF 309 D G Sbjct: 282 LDMGI 286 >UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=Q7N0H1_PHOLL Length = 289 Score = 87.4 bits (215), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 83/289 (28%), Positives = 128/289 (44%), Gaps = 28/289 (9%) Query: 11 CGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTG 70 G+K NP + S + + + + G G VV KTI PR + L E T Sbjct: 13 LGMKIKNPIIVGSGLLSDQAKNIRQFIAHGAGAVVTKTI--------YPRSEKLHTEKTY 64 Query: 71 FI--GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGA 128 G N ++ +E L LR KE+ +I SI E+ + LA + Sbjct: 65 LFSTGMLNNTTYSKKTVEYWLTLLREFKEE--QLPVIVSIHAESPEALASLAVRISAVTD 122 Query: 129 DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD-MCEVAL 187 +E SC + + D +PE V Y + VK + P K++ +GD + Sbjct: 123 APLELGISC--LHADDFTED---TPERVFNYTKVVKERTNTPFAVKLS--LGDNLYGRVQ 175 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 AA GGAD I +T I+ I + G ++NG + GYSG +KP+ L I +R Sbjct: 176 AAVEGGADAITLSDT---ISGIAFDTANGEALLNG---VCGYSGPGIKPMVLAAIYNLRK 229 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 PI G GG++ D E+LL GA T+QV T + ++ Y+ ++ + Sbjct: 230 RG--VTIPILGSGGVQDGNDVHEYLLAGANTVQVYTALHRHMYKTLQRI 276 >UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=Streptomyces ambofaciens ATCC 23877 RepID=A0ADR6_STRAM Length = 297 Score = 87.0 bits (214), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 85/312 (27%), Positives = 140/312 (44%), Gaps = 31/312 (9%) Query: 10 FCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD-HLVKED 68 G++ +P + S + + + +D G VV KTI + P + L++ Sbjct: 7 ILGLRLSSPVVVGSGLLTDQERNIRRLFDDGASAVVTKTI----HPDPGPAGEERLLRLP 62 Query: 69 TGFIGFKNMEQIAEHPLEENLAALRRLKED-YPDKVLIASIMGENEQQWEELARLVQEAG 127 TG + N + P+ + A LRR +D P +IAS+ E+ + ELA LV +AG Sbjct: 63 TGML---NSTTYSRRPVGDWCAMLRRFADDGLP---VIASVHAESPDELAELADLVGQAG 116 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP--NIGDMCEV 185 + +E SC G + +PE V Y AV+R + +P K+ + + E Sbjct: 117 SPALELGISCLNE-----GGGLDDTPERVAAYTDAVRRRTPVPFSVKLAAGERLRERVEA 171 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 ALA GAD I +TV + ++ G + G GYSG +KP+ L I + Sbjct: 172 ALAC---GADAITLSDTVAGLA---VDADTGEVRLGGAF---GYSGAGIKPLVLAEIFGL 222 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 R P+ GG+E D AE+L +GA +QV T + + + + + G +L Sbjct: 223 RRAGLT--VPVMASGGVENGRDVAEYLSVGADAVQVYTALHREMHATLRAIRRGFDEWLG 280 Query: 306 DQGFDSLQEMVG 317 G ++ ++VG Sbjct: 281 AHG-GTVADLVG 291 >UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglobaceae RepID=PYRD_ARCFU Length = 299 Score = 85.9 bits (211), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 83/314 (26%), Positives = 148/314 (47%), Gaps = 28/314 (8%) Query: 12 GVKFPNPFCLSSSPVGN-CYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTG 70 G++ NP L+S +G+ + + A D G VV K++G + R +V G Sbjct: 10 GLRMKNPLMLASGIMGSKVHSLNLIARDAG--AVVTKSVG--VEEREGYRNPTVVNWKCG 65 Query: 71 FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKV-LIASIMGENEQQWEELARLVQEAGAD 129 I + A E L +DY ++ L+ S+ G + +++ +L A Sbjct: 66 LINAVGLASPAAKDFAEEL-------KDYTNEAPLLISLYGHSVEEFSDLVDTFDSALPY 118 Query: 130 M--IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 + E N SCP + G D+G EL +K + P+ AK++ + D ++A Sbjct: 119 LHGYELNLSCPHV--KGAGLDIGMDLELSAAIVEELKGKTKNPVFAKLSA-MHDYLKLAK 175 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 + G DGI NT++ + ID+ G P+++ S G SG A+KPIAL+ + + Sbjct: 176 VLEDAGVDGITISNTLRGM-KIDIMS--GKPVLSNLSG--GVSGPAIKPIALKCVYDLYK 230 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 E+ PI G GGI ++ED EF++ GA +Q+ + + Y RI + L + + Sbjct: 231 EIEV---PIVGCGGITSFEDVLEFIMAGARAVQIGSAV-YYSRRIFYSLKESLIAFTRAR 286 Query: 308 GFDSLQEMVGLANN 321 ++ +++G+A++ Sbjct: 287 DC-TISDLIGIAHS 299 >UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidobacteriaceae RepID=D2RBF2_GARVA Length = 333 Score = 85.9 bits (211), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 62/200 (31%), Positives = 111/200 (55%), Gaps = 14/200 (7%) Query: 82 EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMT 141 +H L + L L+++ ++I ++ G ++ + ++ + ++ ADM+E N SCP +T Sbjct: 109 DHYLVDELPKLKKMGA-----LVITNVAGHSDDDYAQVVEKLADSAADMLEINVSCPNVT 163 Query: 142 SHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAIN 201 M VG P + + + ++ + PM+ KMTPN+ D+ + AA GAD ++ IN Sbjct: 164 HGGM--SVGTDPVALHRLIKRLRAMTDKPMIVKMTPNVTDIVSICKAAVDAGADALSMIN 221 Query: 202 TVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGG 261 T + + ++ + G PI+ ++ G SG A+ PI L F+ ++R + D PI GIGG Sbjct: 222 T---LVGLRIDIRTGEPIIANRT--GGVSGPAIFPIGLGFVWRVRQ--AMPDIPIIGIGG 274 Query: 262 IETWEDAAEFLLLGAATLQV 281 I++ E A E+L GA ++V Sbjct: 275 IDSGEKALEYLYAGANAVEV 294 >UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLU5_9BACT Length = 302 Score = 85.9 bits (211), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 80/315 (25%), Positives = 153/315 (48%), Gaps = 26/315 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DL++ +KF NP ++ P E +A + G GG+V KT+ A P Sbjct: 3 DLTVKLGKLKFINPVLPAAGPNVMRLEQMLEAVERGAGGIVTKTVSREPAVYPKPCISKG 62 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + G N E ++ P + ++KE LI SI G + + EL + ++ Sbjct: 63 PCD-----GLLNCETWSDRPWRSYIDDYVKVKET--GVPLICSI-GYSPEDVAELGKALE 114 Query: 125 -EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 E G D++E ++H VG++ + +++ A++ + P+ K++P+ ++ Sbjct: 115 AEVGPDVVE-------FSTHY----VGKTLDPLKRVAEALRGSVSCPVWMKVSPSTPNIP 163 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E+A DG A+N+V + D+++ P + + SG A+ +AL + Sbjct: 164 EMA-KVMSDYVDGFVAVNSVGPALDFDIDKP--KPRLGTEDGHGWLSGPAITGVALYAVY 220 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q+ +H + D P+ G+GGI T EDA +F++ GA+ + + + ++ G I +AS +S + Sbjct: 221 QI-SHSQ--DKPVVGVGGIRTGEDAVKFIMAGASLVGICSEAIRRGTGIYGKIASEISDW 277 Query: 304 LADQGFDSLQEMVGL 318 + +G+ SL ++ GL Sbjct: 278 MDRKGYGSLDDIRGL 292 >UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4J6_GEMAT Length = 327 Score = 85.1 bits (209), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 82/322 (25%), Positives = 146/322 (45%), Gaps = 28/322 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 K S++ G+ F NP L+S G E+ + GG+ K + V+PR + Sbjct: 20 KPGSVSVAGLAFRNPVVLASGTAGFGQELEDVLDLSAVGGISTKAV------SVAPRPGN 73 Query: 64 LVKEDTGFIG-FKNMEQIAEHPLEENLAALRR-----LKEDYPDKVLIASIMGENEQQWE 117 + F G N +A LE ++RR L +P + +++G + + + Sbjct: 74 PALRVSEFAGGMMNAIGLANPGLE----SVRRDYLPWLPAHHPGTRVFVNVVGNSIEDFA 129 Query: 118 ELARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 + R + + G D E N SCP + A G + G P+ + A + + P+ K++ Sbjct: 130 TVVRGLDDVPGVDAFELNVSCPNV--KAGGLEFGADPQALHALVSAARGATKRPIFVKLS 187 Query: 177 PNIGD-MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 P +G + + A A GA G+ +NT+ T ID +++ P ++ S G SG A+ Sbjct: 188 PTLGAAIADTARVAVDAGATGLTLVNTMPG-TVIDTDRR--RPKLSFGSG--GVSGPALL 242 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 P+ L + R L P+ G+GGI T +DA ++L+ GA+ + V T ++ R E Sbjct: 243 PVGL--LATWRVSRALPTVPLIGLGGISTGDDALQYLMAGASLVGVGTAALRD-PRAPER 299 Query: 296 MASGLSHYLADQGFDSLQEMVG 317 + L + +G + ++G Sbjct: 300 IVRQLQRWCDREGVRDITTLIG 321 >UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 Tax=Proteobacteria RepID=Q0B324_BURCM Length = 325 Score = 84.0 bits (206), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 88/318 (27%), Positives = 148/318 (46%), Gaps = 29/318 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAK-AYD-TGWGGVVFKTIG-FFIANEVSPRF 61 DLS+ ++ NP P C+ + + A D TG G +V K++ +PR Sbjct: 3 DLSVRVGELRLRNPVM----PASGCFAIEYRDALDLTGLGALVIKSVSPVSRPGNPTPRV 58 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 D G G N I +++ L + + V +AS+ + + Sbjct: 59 -----ADAGD-GMLNSIGIPSRGIDDYLEHVLPAYTGHGTPV-VASVSADTADAFARACE 111 Query: 122 LVQEAGADMIECNFSCPQMTSHAM--GSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + IE N SCP + + M G D G + ++V+ A++ + P+ K+TPN Sbjct: 112 ALSRPDVAAIEANISCPNLEADGMAFGMDAGMTRQVVD----AIRTRTGHPLWVKLTPNA 167 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 G++ ++A AA+ GAD I NTV ++ ID+ + P + + + G SG ++KPIAL Sbjct: 168 GNIAKIAQAAQDAGADAIVMGNTVLGMS-IDVRTR--RPSLG--NVMGGLSGPSIKPIAL 222 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q + P+ G GGI + DA EFLL GA+ +QV T + ++ + G Sbjct: 223 RLVHQCYRAVSI---PVIGCGGIRSAADAIEFLLAGASAVQVGTASFR-DPGVMRTIIDG 278 Query: 300 LSHYLADQGFDSLQEMVG 317 L + AD+G ++ + G Sbjct: 279 LEQFCADEGIGAIASLTG 296 >UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacteria RepID=Q47C62_DECAR Length = 336 Score = 84.0 bits (206), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 86/345 (24%), Positives = 156/345 (45%), Gaps = 37/345 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTI---GFFIANEVSPRF 61 DLS T+ G+ NP SS+P+ + + D G +V ++ ++ RF Sbjct: 3 DLSTTYLGLSLKNPLVPSSTPLSHDLDAVLHLEDAGAAAIVMHSLFEEDVRHDEQMIDRF 62 Query: 62 DHLVKEDT-----GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW 116 LV DT G + F + Q L+ L ++RLK V +AS+ G + W Sbjct: 63 --LVHPDTFGEATGHLPFGHDYQSR---LDSYLEQIQRLKSRLAIPV-VASLNGSSLSGW 116 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKY----CRAVKRGSTLPML 172 EL + +Q AGAD +E N + M SD S E +E + + +K ++P+ Sbjct: 117 VELGKEMQGAGADALELN-------AWYMPSDPKISCEAIEDHHVSLLQELKTVVSIPVS 169 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 K++P + + GA GI+ N +IDL + +V+ S Sbjct: 170 MKLSPFFSSLPHFVHQIEMAGAAGISLFNRFFQ-PDIDLET---LSVVDRVQ----LSSS 221 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 A +A+R+I +R +L ++ GG+ T EDA + LL GA + + +++ G + Sbjct: 222 ADTLLAMRWIAILRGSTKLS---LAATGGVHTAEDALKMLLAGADVAHMASALLKRGPQA 278 Query: 293 VEDMASGLSHYLADQGFDSLQEMVG-LANNNIVPAEDLDRSYIVY 336 + ++ + ++H+L + + S+ +M G ++ N D R+ ++ Sbjct: 279 LGEVLAAMTHWLDEHEYSSVAQMKGSMSQQNSPNPSDFARAAYLH 323 >UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMB2_9BACT Length = 304 Score = 84.0 bits (206), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 111/220 (50%), Gaps = 13/220 (5%) Query: 104 LIASIMGENEQQWEELA-RLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR 161 +IA++ E+E+ + RLV+ A D IE N SCP + M G SP L + Sbjct: 96 IIANVSMEDERGLALIVERLVEVADCVDAIELNVSCPNVDKGCMSW--GVSPVLTSQAVS 153 Query: 162 AVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVN 221 V++ P+ KMTP D VA AA+ GAD + NT + ID++ + + Sbjct: 154 MVQKIWKGPLWVKMTPQAPDPEGVARAAEDSGADALVVANTWLGMA-IDVDSRKAV---- 208 Query: 222 GKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 ++G+SG AV P+ALR + Q+ + + P+ G GG+ + D ++ GA +++ Sbjct: 209 FDRVVAGFSGPAVFPMALRLVWQVSSAVSI---PVIGCGGVSSGRDLLSMIMAGATAVEL 265 Query: 282 TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 TG+ + R+ E++ + Y+ + + L+ ++G+A Sbjct: 266 GTGMFR-DIRLPENILREVKAYMTKEKVEDLRSLIGIAKR 304 >UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E0W2_METI4 Length = 344 Score = 83.2 bits (204), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 86/347 (24%), Positives = 156/347 (44%), Gaps = 34/347 (9%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 ++ L T+ G+K +P S+SP+ + + G G VV ++ ++ Sbjct: 1 MSTSLETTYLGLKLSSPLVPSASPLSKSIDTVKALEEMGAGAVVLYSL---FEEDIEKEA 57 Query: 62 DHLVKEDT-GFIGF-KNMEQIAEHP-----LEENLAALRRLKEDYPDKVLIASIMGENEQ 114 HL + T G F + + + E P + L LRRLKE + IAS+ ++ Sbjct: 58 LHLERSVTMGTESFAEALSYVPEVPGLKMGPDYYLDHLRRLKESVSIPI-IASLNAQSPG 116 Query: 115 QWEELARLVQEAGADMIECN-FSCPQMTSHAMGSDVGQSPELVEKYCRAV---KRGSTLP 170 QW + A+L++EAGAD +E N +S P S + S EL ++Y V ++ +LP Sbjct: 117 QWVKYAKLIEEAGADALELNLYSIPTQESLS-------STELEQRYLEIVSACRQSVSLP 169 Query: 171 MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 + K++P + + ++ G+ N +IDL P + + Sbjct: 170 IAVKLSPFFTNFFSFSSRVEKTAVQGLVLFNRFFQ-PDIDLENMTVEPRITLSTE----- 223 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G+ + I I R +L S GGI + D + LL GA T+Q+ + ++ +G Sbjct: 224 GELLLRITWIGILYNRVKLDL-----SATGGILSSTDVLKALLSGATTVQLCSALLYHGV 278 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVP-AEDLDRSYIVY 336 ++ + +G+ +L ++G+ S+ E+ GL + P +R+ VY Sbjct: 279 EYLKTVKNGVVEWLEEKGYRSINEIRGLLSQKNCPDPSSYERAQYVY 325 >UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 Tax=Actinomycetales RepID=A0LUF8_ACIC1 Length = 351 Score = 83.2 bits (204), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 98/339 (28%), Positives = 154/339 (45%), Gaps = 39/339 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 DL+ V PNP +S E+ + G VV K+I A +PR Sbjct: 26 DLTTQLGSVVLPNPVTTASGCAAAGRELGQFVDVSTLGAVVTKSIMLAPRAGRPTPRMAE 85 Query: 64 LVKEDTGFIGFKN--MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG + +++ EH L L E I SI G + ++ LA Sbjct: 86 TPSGLLNGIGLQGPGIDEFLEHDLPW-------LAEHGARA--IVSIAGSSVGEYAALAA 136 Query: 122 LVQEAGADM-IECNFSCPQMTSHAMGSDVGQ----SPELVEKYCRAVKRGS--TLPMLAK 174 ++ A + +E N SCP + D GQ P AV+ + +P+ AK Sbjct: 137 RLRGAAPVVALEVNISCPNV------EDRGQVFACDPRAASAVLAAVREAADPAVPVFAK 190 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 ++P++ D+ VA A GADG++ INT+ + ++ + P ++G + G SG A+ Sbjct: 191 LSPDVTDIVAVATACVAAGADGLSLINTLLGLV---IDTETLRPALSGVTG--GLSGPAI 245 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ---YGYR 291 +P+A+R + Q+ H L D PI G+GGI + DA +FLL GA + V T I R Sbjct: 246 RPVAVRCVWQV--HAALPDVPIIGMGGIRSGLDALQFLLAGACAVSVGTEIFHDPSAPAR 303 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 I +++A LA +GF + +++GLA+ AE D Sbjct: 304 IRDELA----EALAARGFQRVSDVIGLAHRGGSVAEGGD 338 >UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycetales RepID=A1UMT4_MYCSK Length = 340 Score = 80.5 bits (197), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 82/327 (25%), Positives = 138/327 (42%), Gaps = 39/327 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS + G++ NP ++SP+ + + D G G VV ++ F+ Sbjct: 2 DLSTRYLGLELRNPLLAAASPLSRTLDGVKQLADAGVGAVVLYSL-----------FEEQ 50 Query: 65 VKEDTG-------FIGFKNMEQIAEHP--LEENLAALR--RLKEDYPDKV---LIASIMG 110 ++ + F + E + P + E A R RL E +V +I S+ G Sbjct: 51 LRREAADNARMATFANETHAESVTYFPSTVGEGDGARRHLRLLERAAAEVEVPVIGSLNG 110 Query: 111 ENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 W AR +++AGA IE N SH G +V Q + AVK LP Sbjct: 111 STPGGWVRHARAMEDAGAAAIELNIYQLPGDSHISGREVEQRHLDI---LAAVKDTVDLP 167 Query: 171 MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 + K++P E+AL + GADG+ N L I ++ S ++ S Sbjct: 168 VAVKLSPFFSATAEMALRLDQAGADGLVLFNRF-------LQPDIDSETISVTSEVT-LS 219 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 A + +I +R D ++ G+E D A++LL GA +Q + ++++G Sbjct: 220 VPAEARLPRTWIALLRGRI---DASLAATTGVEDAGDVAKYLLAGADVVQTASALLRHGP 276 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVG 317 + +GLS +LA + F +L ++ G Sbjct: 277 EYAGVLLTGLSDWLARKSFHALHQVRG 303 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 79.0 bits (193), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 114/249 (45%), Gaps = 47/249 (18%) Query: 73 GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIE 132 G + + Q+A H ++E + + RL+E P IE Sbjct: 99 GTRVIMQMAAHSVQEMIDVVERLEELNPH--------------------------ISAIE 132 Query: 133 CNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRG 192 N SCP + G +G +PE + +AV+ + LP+L KM P ++ E+ A + Sbjct: 133 LNVSCPNLEKG--GRPLGGTPEQATEIMKAVRPLTKLPILVKMAPV--NVAEIGKAFEAE 188 Query: 193 GADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS----GYSGKAVKPIALRFIQQMRTH 248 GADG+ IN++ ++ I+++ + KS +S G SG A+R + + Sbjct: 189 GADGLTLINSIPGMS-INVHTR--------KSRLSKPTGGLSGPLCHNAAVRMVWECA-- 237 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 + PI G+GG+ET EDAAEF+L GA + V + + Y + + L+ + QG Sbjct: 238 -QAVSIPICGVGGVETGEDAAEFILAGATAVSVGSANL-YDPMCAPRILNELTDWAKSQG 295 Query: 309 FDSLQEMVG 317 + E++G Sbjct: 296 VSDIHELIG 304 >UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECL7_9ACTN Length = 302 Score = 78.6 bits (192), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 75/270 (27%), Positives = 122/270 (45%), Gaps = 54/270 (20%) Query: 53 IANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN 112 A E P + L K+ G + + Q+A H ++E + AL E P Sbjct: 78 FARESGPWLEQLSKD-----GCQVICQVAGHSVDEFVRALEMYVELCP------------ 120 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 W A E N SCP + A G+ +G +PE A ++ + P+ Sbjct: 121 ---W-----------AAGYEINVSCPNIA--AGGAAMGSTPEGASSVMAACRKVTDKPLF 164 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS----G 228 KM P ++ E+A A + GADG++ IN+++ + ID++ + KS ++ G Sbjct: 165 VKMAPV--NVAEIAKALEAAGADGLSVINSIQGMA-IDVHTR--------KSRVAKPKGG 213 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG IA+R + ++ + D PI+G+GG+ T EDAAEF+L GA V+ G+ + Sbjct: 214 LSGPLCHHIAVRMVWEVA---QAVDIPINGVGGVMTGEDAAEFILAGATC--VSVGMANF 268 Query: 289 GYRIVE-DMASGLSHYLADQGFDSLQEMVG 317 +A L + QG + E+VG Sbjct: 269 VDPCASLKIAHELEAWAESQGVKDINELVG 298 >UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F860_9ACTN Length = 307 Score = 78.2 bits (191), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 85/333 (25%), Positives = 142/333 (42%), Gaps = 46/333 (13%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSP 59 M ++++ F GVK NP +S G ++ + G + K +P Sbjct: 1 MSQVNMAVDFGGVKMKNPINTASGTFGYGWQFSELMDVSQLGAITTKGCAAEAWPGNPAP 60 Query: 60 RFDHLVKEDTGFIGFKN--MEQIAEH--PLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 R + +G +N + AE P +L A +I + G + ++ Sbjct: 61 RMAEVPGGMMNSVGLQNPGVAAFAEQSGPWLADLTA--------KGTQVICQVAGHSTEE 112 Query: 116 WEELARLVQE--AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 + + E A E N SCP + A G+ G +PE + RA ++ + P+ Sbjct: 113 YVRALEMFVELCPWAAGYEINVSCPNIA--AGGAACGSTPEGASEVMRACRKVTDKPLFV 170 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS----GY 229 KM P + E+A A + GADG+ IN++ ++ ID+ + +S +S G Sbjct: 171 KMAPV--RIPEIARALEAEGADGLTVINSIPGMS-IDVRTR--------RSRLSKPTGGL 219 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY- 288 SG PIA+R + + D PI G+GG+ T EDAAEF+L GA V+ G+ + Sbjct: 220 SGPLCHPIAVRMVWEAANA---VDIPICGVGGVMTGEDAAEFILAGACC--VSVGMANFV 274 Query: 289 ----GYRIVEDMASGLSHYLADQGFDSLQEMVG 317 RI+ + L + QG + E++G Sbjct: 275 EPDASVRILHE----LEAWAESQGVKDINELIG 303 >UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular organisms RepID=PYRD_YEAST Length = 314 Score = 77.8 bits (190), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 67/241 (27%), Positives = 118/241 (48%), Gaps = 18/241 (7%) Query: 89 LAALRRLKEDYPDK-VLIASIMGENEQQWEELARLVQEAGADMI-ECNFSCPQMTSHA-M 145 L+ + +++YPD + S+ G + + L R +Q++ + I E N SCP + + Sbjct: 83 LSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQV 142 Query: 146 GSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKS 205 D + E +EK K+ P+ K+ P D + AK +A +N++ S Sbjct: 143 AYDFDLTKETLEKVFAFFKK----PLGVKLPPYF-DFAHFDIMAKILNEFPLAYVNSINS 197 Query: 206 ITN---IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM--RTHPELRDFPISGIG 260 I N ID+ ++ +V K+ G G+ VKP AL ++ R PE++ + G G Sbjct: 198 IGNGLFIDVEKE--SVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIK---VIGTG 252 Query: 261 GIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 GI++ +DA E LL GA+ LQ+ T + + G +I E + L + +G+ S+ + G N Sbjct: 253 GIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLN 312 Query: 321 N 321 + Sbjct: 313 S 313 >UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter vinelandii DJ RepID=C1DSD9_AZOVD Length = 332 Score = 75.1 bits (183), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 85/326 (26%), Positives = 135/326 (41%), Gaps = 39/326 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 +L+ T+ G+ NP S+SP + + D G G VV ++ F Sbjct: 2 NLTTTYLGLSLRNPLIASASPQNAELDHLHRLDDAGIGAVVLPSV-----------FQEQ 50 Query: 65 VK---EDTGFIGFKNMEQIAEHPL----------EENLAALRRLKEDYPDKVLIASIMGE 111 ++ D IG + A P E +LA + R K + V IAS+ G Sbjct: 51 LEAGANDYASIGAACSDVPAFLPPVEGGPYGMIPESHLALIMRAKAELSVPV-IASLNGA 109 Query: 112 NEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 + W A L++EAGAD +E N + G+ V Q + AV+R +P+ Sbjct: 110 SANHWTHYAALLEEAGADALELNLYFVPVDPLEPGTAVEQR---YLEVLAAVRRTVKIPV 166 Query: 172 LAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 KM P + +A GGADG+ N +IDL + PI + S G Sbjct: 167 AVKMPPYFSAIGNMASRLLEGGADGLVIFNRYLQ-PDIDLQRL--QPISTLELSSPGEMR 223 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + IAL +++ ++ GG+E E ++LL GA T+ T I+++G Sbjct: 224 LPLLWIAL-LAGRVKGS-------LAASGGVEDVEQVVKYLLAGADTVMTTAAILRHGPA 275 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVG 317 V + GL +L + SL+ + G Sbjct: 276 HVHTLLCGLEAWLQSRRGQSLERIRG 301 >UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VIM3_9BACT Length = 305 Score = 74.7 bits (182), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 110/222 (49%), Gaps = 21/222 (9%) Query: 104 LIASIMGENEQQWEELAR-LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 LI S G + +++ ++ L ++ G E N SCP + + G G P++V K C Sbjct: 99 LIVSFSGSSLKEFVQMLECLEKQEGISGYEVNVSCPNVENE--GIAFGIDPDVVNKLCAL 156 Query: 163 VKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 + + ++ K++PN+ D+ +A AA+ GGA I+ INT+ + ID NG Sbjct: 157 LSPLTERELIVKLSPNVTDIAVIAKAAEEGGATAISLINTIWGMA-IDYR--------NG 207 Query: 223 KSSIS----GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAAT 278 KS I GYSG +KP+AL + ++ P+ +GGI W+DA EF GA+ Sbjct: 208 KSRIKKGIGGYSGIGIKPLALALTYRAAQAVKI---PVIAMGGIYNWQDALEFFWAGASM 264 Query: 279 LQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 + + T V+ + GLS + ++ L+++VG N Sbjct: 265 IALGTANF-IDPLAVDKVYEGLSSFCLEKQL-KLKDIVGKVN 304 >UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobaceae RepID=PYRD_SULAC Length = 291 Score = 74.3 bits (181), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 108/218 (49%), Gaps = 20/218 (9%) Query: 104 LIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV 163 LI SI G N ++ + + + MIE N S P S++ E+V+ V Sbjct: 89 LIISIGGSNVNEYIDAVSKINDIPV-MIELNVSSPNRRGFGE-SNLTYVEEIVKNVKSIV 146 Query: 164 KRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK 223 K+ P+ K+ P ++ E+A A GADG+ INT+K + ID+ PI++ Sbjct: 147 KK----PVFVKLGP-WDNIVEIAGRALSAGADGLTLINTLKGML-IDVEDF--KPILS-- 196 Query: 224 SSISGYSGKAVKPIALRFIQQM--RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 G SGK + +A+R I + PE I G+GG+ W DA E + +GA + + Sbjct: 197 YGTGGISGKCIHALAVRVIHDVFKEYEPE-----IIGVGGVFDWRDAIELISVGAKLVGL 251 Query: 282 TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 T +++ G+ ++ ++ G+ YL ++G ++E+ G+ Sbjct: 252 GTVLVEKGFDVIREIREGIGTYLEEKGL-KVEEIRGIG 288 >UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=B8EIT2_METSB Length = 337 Score = 73.9 bits (180), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 79/336 (23%), Positives = 136/336 (40%), Gaps = 54/336 (16%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKT---------------- 48 DL + G+ P S+SP+ + + D+G G VV + Sbjct: 2 DLRTRYLGLSLRTPLIASASPLSGDVGLIRQMEDSGAGAVVLPSLFQEQIEEEARAADEL 61 Query: 49 --IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIA 106 IG + E S F +V ++G G+ + L A R D P +IA Sbjct: 62 ARIGADSSPEASSYFPAVVTYNSGPHGYLD------------LVARARAAVDIP---VIA 106 Query: 107 SIMGENEQQWEELARLVQEAGADMIECNF----SCPQMTSHAMGSDVGQSPELVEKYCRA 162 S+ G W + ARL+++AGA +E N S P +T GQ+ A Sbjct: 107 SLNGTTVAGWVDYARLIEQAGATALELNIYRIASGPGVTG-------GQAEADCVALLEA 159 Query: 163 VKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 V+ LP+ K+ P + A GADG+ N + +IDL + Sbjct: 160 VRSRVKLPVAVKLHPYFSAFGDFAQQLDHAGADGLVLFNRLYQ-PDIDLLRLAW----KN 214 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 +++SG + + L + H L + G++T E+ +++L GA + Sbjct: 215 DATLSGAGEIRLGLLWLSVLSGRLPHASL-----AAGTGVDTAEEVIKYILAGANAVMTA 269 Query: 283 TGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 + ++++G + + SGL +L+ +GF S+ + GL Sbjct: 270 SSLLRHGPGHLRTLVSGLETWLSTRGFASVSAITGL 305 >UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella benthica KT99 RepID=A9D5Y9_9GAMM Length = 334 Score = 73.9 bits (180), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 69/264 (26%), Positives = 114/264 (43%), Gaps = 17/264 (6%) Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 PR+ L +G N+ E L L++ +K ++ S+ G + Sbjct: 78 PRYQALPLGSIQSMGLPNL---GYQAYLEMLPRLKQAISPQTNKPIVVSVSGFSLADNLT 134 Query: 119 LARLVQEAGADMIECNFSCPQMTSHA-MGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + + Q + AD+IE NFSCP + +G D Q+ +E+ C+ + P+ K+ P Sbjct: 135 MVKAFQASCADLIEVNFSCPNIEGKPQVGYDFEQTERALEQLCQLGSK----PIGLKLPP 190 Query: 178 --NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 + +A K+ I IN+V + ID + I+ K G G +K Sbjct: 191 YFDFSHFITMANIIKKFPVRFITCINSVGNTLVIDPETESA--IIKPKGGFGGLCGDYIK 248 Query: 236 PIALRFIQQMRTHPEL--RDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 PI L +R +L I G+GGI+T DA E+LL GA+ +QV T + G Sbjct: 249 PIGL---ANVRAFSQLLPSSIDIIGVGGIKTGTDAFEYLLAGASAVQVATCFEKEGIECF 305 Query: 294 EDMASGLSHYLADQGFDSLQEMVG 317 + +A L +A + + S+ G Sbjct: 306 DRIAKELDSIMAAKQYSSIAAAKG 329 >UniRef50_C2MA24 Dihydroorotate dehydrogenase 2 n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MA24_9PORP Length = 327 Score = 73.6 bits (179), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 75/324 (23%), Positives = 142/324 (43%), Gaps = 30/324 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DL+ + G+ NP SS + + G G V+ K++ F + Sbjct: 3 DLTSHYGGIALRNPIIAGSSGLTASLQQIKALAQAGAGAVILKSL--FEEQIEATALQAE 60 Query: 65 VKEDTGF-IGFKNM-EQIAEHPLEENLAALRRLKE--DYPDKVLIASIMGENEQQWEELA 120 + T + G M +H +E+ L +R K+ D P +IAS+ +WE A Sbjct: 61 AEMATSYPEGLDYMLHYTRQHEVEKYLDLIREAKQAIDIP---VIASVNCYRGGEWEAFA 117 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + +QEAGAD +E N + GSD+ Q ELV+ ++ R +P++ K++ Sbjct: 118 QSIQEAGADALELNVMRIETDPAQRGSDLEQ--ELVD-LAISITRTVQIPVVFKISDRFT 174 Query: 181 DMCEVALAAKRGGADGIAAIN-TVKSITNIDLNQKIGMPIVNGKSSISG---YSGKAVKP 236 ++ +A + G G+ N + ++ NI+ + + P+++ + Y+G Sbjct: 175 NILYLAQELVKSGVKGLTCFNKSWQTDINIETLEIVQGPVISTGHELYNTLKYTGLLTGK 234 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 + P+L +S GG+ + + LL+GA+++QV + + Q+G + M Sbjct: 235 L-----------PQL---AVSASGGVMDYAGVVKSLLVGASSVQVVSALYQHGASYLTKM 280 Query: 297 ASGLSHYLADQGFDSLQEMVGLAN 320 L+ ++ G+ S+ E G N Sbjct: 281 LEELTQWMTQHGYRSIDEFRGNLN 304 >UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Rickettsiella grylli RepID=A8PKY4_9COXI Length = 355 Score = 73.2 bits (178), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 66/206 (32%), Positives = 103/206 (50%), Gaps = 30/206 (14%) Query: 102 KVLIASIMGENE------QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSD--VGQSP 153 +VLI S+ GE Q + A + +EAGAD+IE NFSCP + M SD + ++ Sbjct: 154 QVLIVSVYGEGHSLSAMSQDFMTAALMAKEAGADIIELNFSCPNL----MKSDEPLYRNM 209 Query: 154 ELVEKY-CRAVKRGSTLPMLAKMTPNIGDMCE------VALAAKRGGADGIAAINTVKSI 206 + V + R VK +P+L K IG + E + ++A R G GI+AIN++ S+ Sbjct: 210 DCVSQITTRVVKCVGDIPLLLK----IGFIHEHEFPLKLLISAARAGVRGISAINSI-SM 264 Query: 207 TNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR--THPELRDFPISGIGGIET 264 ++ N + GK SG SG ++ +AL+ ++++ E + I G+GGI Sbjct: 265 RVLNQNHRPAF----GKRIYSGISGYPIRRLALQSVKKLTQINQKEKLNLTIVGMGGITV 320 Query: 265 WEDAAEFLLLGAATLQVTTGIMQYGY 290 E EF GA + TG+M Y Sbjct: 321 AEHFDEFFDRGADAVLSATGVMWNPY 346 >UniRef50_D2S9D7 Dihydroorotate oxidase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S9D7_9ACTO Length = 385 Score = 72.8 bits (177), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/235 (30%), Positives = 111/235 (47%), Gaps = 29/235 (12%) Query: 85 LEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEELARLVQEAGADMIECNFSCPQ 139 LE +LAA+ +D D++L+ S+MGE + + ARL QEAGA ++E N SCP Sbjct: 157 LERSLAAV----DD--DQLLLVSVMGEGDGTGLVDDFAATARLAQEAGASVVELNLSCPN 210 Query: 140 M--TSHAMGS------DVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKR 191 TS A G D G + +VE RA+ + L +AK++ G E + Sbjct: 211 TLSTSTAAGVKPPLCLDAGATVAVVEGVRRALDDRTGL--VAKLSWLDGARLEALVPRLA 268 Query: 192 GGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPEL 251 DGIA INT++S + + G P G+ ++G SG AV+ AL F +++ + Sbjct: 269 PLVDGIAGINTLQS----RVRRSDGEPTFPGR-ELAGLSGAAVRDSALDFTRRLVALRDA 323 Query: 252 --RDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 R F + +GG+ A LGA +Q +G + + D + L L Sbjct: 324 GGRHFDVLAMGGVTDPASFAALFALGADAVQSASGAFAAPF-LARDCVAALGETL 377 >UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6B3_9ACTN Length = 309 Score = 72.0 bits (175), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 108/241 (44%), Gaps = 43/241 (17%) Query: 79 QIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP 138 Q+A H ++E +AAL +E + + A E N SCP Sbjct: 106 QVAGHSIDEYVAALEVFEE--------------------------KASFAAGFEINISCP 139 Query: 139 QMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIA 198 + G+ +G +P+ + R ++ + P+L KM P ++ E+A A + GAD ++ Sbjct: 140 NIACG--GAAMGSTPQGAAEIMRRLRPLTKRPLLVKMGPV--NIPEIARALESEGADALS 195 Query: 199 AINTVK--SITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPI 256 IN++ +I K+ P G+SG A+ PIA+R + + H ++ P+ Sbjct: 196 LINSIPGMAIDTTTYKSKLSRPT-------GGFSGPAIHPIAVRMVWE--AHKAVK-IPL 245 Query: 257 SGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMV 316 GIGGI T +AAEF+L GA + V + Y + L + QG + +++ Sbjct: 246 CGIGGITTGLEAAEFILAGATAVSVGLANL-YDPMSAPRILHELCDWAQKQGVTRISDLI 304 Query: 317 G 317 G Sbjct: 305 G 305 >UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroides RepID=C3PUX9_9BACE Length = 324 Score = 71.2 bits (173), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 72/322 (22%), Positives = 136/322 (42%), Gaps = 41/322 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTI--------GFFIANEV 57 L TF G+ NP +SSS + N E K G G +V K++ +A Sbjct: 4 LKTTFAGLSLRNPIIISSSSLTNSAEKNKKLELAGAGAIVLKSVFEEQIMMEAHHMATYG 63 Query: 58 SPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKE--DYPDKVLIASIMGENEQQ 115 SP D + + H L E ++ + + K+ P +IASI + + Sbjct: 64 SPEGDDYLST-----------YVRSHALNEYISLIEQTKKLCTIP---VIASINCFSNSE 109 Query: 116 WEELARLVQEAGADMIECN-FSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 W + AR V+ AGAD +E N S + GS + ++V ++K+ ++P++ K Sbjct: 110 WTDFARTVETAGADALEINILSLQTEKEYQCGSFEQRHIDIVS----SIKKQISIPVIVK 165 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTV-KSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 + N+ + + GA+ + N + NID + + + +S Sbjct: 166 LGSNLTNPIALINQLYANGANAVVLFNRFYQPDINIDTMTYSAGDVFSTPADLSN----- 220 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 LR+ D+ ISG G+ + + +L GA+ +++ + I Q G +++ Sbjct: 221 ----GLRWTAIASAQVPQTDYAISG--GVHDGKAIVKAILAGASAVELCSVIYQRGNQVI 274 Query: 294 EDMASGLSHYLADQGFDSLQEM 315 DM + ++ ++ QG+ ++ E Sbjct: 275 ADMTNEITQWMNRQGYKNISEF 296 >UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidobacteriaceae RepID=C6A9A6_BIFLB Length = 386 Score = 70.9 bits (172), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 92/333 (27%), Positives = 140/333 (42%), Gaps = 45/333 (13%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI----ANEVSPRF 61 L G+ F NPF LS+ NC +M A G+G F+T+G A P F Sbjct: 77 LETNVMGINFANPFGLSAGLDKNC-DMAAVLDHAGFG---FETVGSTTSRPCAGNPRPWF 132 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L + D+ + ++ +E A RR + L SI N+ Q +L Sbjct: 133 HRLPEYDSMMVHVGLANDGSDVVIERAEDAWRRTQS----MQLSVSIARTNDDQVGDLNE 188 Query: 122 LVQE--------AG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPM 171 +++ AG M+E N SCP T +G +S E ++K A+ R P Sbjct: 189 GIEDYCISMERAAGRTAMVEVNVSCPNTT---VGEPFTESAENLDKLFAALDRIERPQPT 245 Query: 172 LAKMT-----PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 L KM P + +V LAA G+ N K T +D +P K + Sbjct: 246 LVKMPLNKPWPQFKEFLDV-LAAH--NVQGVTIANLQKDRTGLD-----DIP----KDWL 293 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRD-FPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SG + I+ RT+ E D F I+G+GG+ T E A E + G++ + + + Sbjct: 294 GGLSGGPCTVASTELIR--RTYAEYGDRFAIAGVGGVFTPEQAYEKIRAGSSLIMFISSL 351 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 M G + + + GL+ L GF S+ E VG+ Sbjct: 352 MYRGPQQITVLKRGLAKLLRRDGFGSVAEAVGV 384 >UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 Tax=Bacteria RepID=A6L9F5_PARD8 Length = 325 Score = 70.5 bits (171), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 75/331 (22%), Positives = 142/331 (42%), Gaps = 36/331 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 D+ + G+ NP + SS + N E G G +V K++ ++ + + L Sbjct: 3 DIKTQYAGLTLRNPIIVGSSGLTNKAERNRDFEKAGAGAIVLKSL---FEEQIEMQSEAL 59 Query: 65 VK-----EDTGFI-GFKNMEQIAEHPLEENLAALRRLKE--DYPDKVLIASIMGENEQQW 116 ++ E +I G+ Q+ ++ L +++ KE P +IASI W Sbjct: 60 MQDSDYPEAADYIRGYVKANQVNDY-----LELIKKSKELCTIP---IIASINCYKADAW 111 Query: 117 EELARLVQEAGADMIECN--FSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 + AR ++ AGAD +E N F ++T D + R VK ++P++ K Sbjct: 112 IDFARQIELAGADALELNVFFMETELTE-----DFESIRDTYVSIIRKVKETVSIPVIMK 166 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 + N ++ + K GADG+ N +ID+N M IV+G +S + Sbjct: 167 IGKNYSNIPSLVNLLKVNGADGVVLFNRFYQ-PDIDIN---NMQIVSGNV----FSNHSD 218 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 +R+ + ++ I+ G+ WED + LL GA+ +Q+ + + +G I+ Sbjct: 219 LSDTIRWTAIVS--GKIPGISIASSTGVHDWEDVVKCLLAGASAVQMCSAVYTHGAEIIS 276 Query: 295 DMASGLSHYLADQGFDSLQEMVGLANNNIVP 325 + + + ++ + SL + G N +P Sbjct: 277 QVLTCVEEWMHQAHYQSLSQFQGKLNYANIP 307 >UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVZ1_RUBXD Length = 304 Score = 70.5 bits (171), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 89/321 (27%), Positives = 149/321 (46%), Gaps = 36/321 (11%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN-EVSP 59 M+ +LS+ CGV+ P +S + E +A +G V+ KT+ P Sbjct: 1 MVAPELSVELCGVRLATPLIPASGTLAP--EALGEAAGV-YGAVLPKTVTLRPRQGNPPP 57 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R IG +N +EE L AL + P + S+ GE +++ L Sbjct: 58 RVAESPAGMVNSIGLQN------PGVEEFLRALGAWEVGVP---VFVSVAGETVEEFALL 108 Query: 120 -ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-LPMLAKMTP 177 R+ + A IE N SCP + G P VE+ A +R + +P+LAK+ Sbjct: 109 CGRVAADGRAAAIELNLSCPNVERG--GQVFCAGPSAVEEVVAACRRAAPDVPLLAKLA- 165 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + + ALAA+ GADG+ +NTV ++ +++ ++ G G SG A+KP+ Sbjct: 166 -LEGVVQNALAAEAAGADGLTVMNTVPALAVDARARRV---LLRG-----GLSGPAIKPL 216 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV-TTGIMQYGYRIVEDM 296 ALR + + + E+ P+ G GG+ + D AEF+L GA +QV + G ++ I+ + Sbjct: 217 ALRAVYDVASAAEI---PVVGCGGVCSGADVAEFMLAGARAVQVGSAGFVRDPAEILAE- 272 Query: 297 ASGLSHYLADQGFDSLQEMVG 317 YL ++G + E+ G Sbjct: 273 ---FERYLREEGLAA-SELAG 289 >UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SLA1_9BACT Length = 328 Score = 69.7 bits (169), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 82/359 (22%), Positives = 138/359 (38%), Gaps = 50/359 (13%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS------ 58 D+ +F G+ NP + SS + + E D G VV K++ EV Sbjct: 3 DIRTSFMGLTLKNPVIVGSSTLTDTPEKIKALADNGAAAVVLKSL---FEQEVRNLKDSA 59 Query: 59 ------PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALR--RLKEDYPDKVLIASIMG 110 P + D G + + + E L +R +L D P +IASI Sbjct: 60 QCCNYHPEAYYYDMSDAGML----------YGISEYLQLIRDAKLATDIP---VIASICC 106 Query: 111 ENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 E W+ + AGAD +E N + + +D+ + + VK + LP Sbjct: 107 EKAAWWKTYPERIANAGADALELNINMLSLHGAKSPADIYKD---TLQIIHTVKNTTDLP 163 Query: 171 MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K++P + + K GA G+ + + + I+ N P S YS Sbjct: 164 FSVKLSPYCCSIPYLVKMLKEEGAKGVTLFSRLFEL-GINTNTFECEP-------ASYYS 215 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 LR++ + E D I G GI T + + ++ GA +Q+ + I + G Sbjct: 216 SPEETFKVLRWVHLVS---EQVDIEICGNTGIHTSREIIQHIIAGAGAVQMVSSIYKNGP 272 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSY---IVYPRINLDKCVG 346 I+ L Y+ D+ F++L E+ G + +D D Y + + R LD +G Sbjct: 273 EIIRTCLEELEQYMFDRQFNTLHELKGFLSTK---EKDFDLLYFNSLTHDRFQLDSHMG 328 >UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q682_MALGO Length = 665 Score = 68.9 bits (167), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 68/229 (29%), Positives = 107/229 (46%), Gaps = 37/229 (16%) Query: 93 RRLKEDYPDKVLIASIMGENEQQWEE----LARLVQEAGA--DMIECNFSCPQMTSHAMG 146 R LK+D L++ +G+N+ E+ + VQ GA DM+ N S P G Sbjct: 253 RSLKQDR----LLSINLGKNKSSREDSVVDYVKGVQALGAYADMLVINVSSPNTP----G 304 Query: 147 SDVGQSPELVEKYCRAV---------KRGSTLPMLAKMTPNIGD--MCEVALAAKRGGAD 195 Q ++E R V +R +LP++ K+ P++ D + +VA AA+ D Sbjct: 305 LRRLQRRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELEDVADAARASKID 364 Query: 196 GIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFP 255 GI ++N +++ G+ G SG VKP+AL +Q + E + P Sbjct: 365 GII-------VSNTTVSRPAGLLSTQHVHEAGGLSGPPVKPLALHALQVIYKRSEGK-IP 416 Query: 256 ISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG----YRIVEDMASGL 300 + G GGI T EDA EF GA+ +Q+ T + G RI +D+A+ L Sbjct: 417 LIGCGGIMTAEDALEFARAGASAVQLYTALAYRGPGLPRRIKDDLAARL 465 >UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M0V6_ACIFD Length = 309 Score = 68.2 bits (165), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 105/226 (46%), Gaps = 18/226 (7%) Query: 93 RRLKEDYPD----KVLIA-SIMGENEQQWEELARLVQEAGADM--IECNFSCPQMTSHAM 145 R L E +P ++ +A S+ G + + E R + IE N SCP + A Sbjct: 80 RWLAETWPSLADARIPVALSVWGRQPRDYGETVRRAARIAPSLVYIELNLSCPNL--EAD 137 Query: 146 GSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKS 205 + P + AV+ P+L K++ N + +VA AA GADG+ AINT+ + Sbjct: 138 RALFAHDPNATARVVGAVRDEVATPILVKLSANTDRIVDVAHAAVAAGADGLVAINTLFA 197 Query: 206 ITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETW 265 D + + G + G SG+AV+PIALR + +R L PI G+GG+ T Sbjct: 198 QWYDDGREAL------GTARGGGLSGRAVQPIALRAVADLRA--ALPTVPIIGVGGVATA 249 Query: 266 EDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDS 311 +D F+ GA +Q+ T + R V +A + LA G DS Sbjct: 250 DDVERFVRAGADAVQIGTALFVDPRRPVLVLAE-IERRLARSGVDS 294 >UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebacterineae RepID=PYRD_MYCTA Length = 357 Score = 67.8 bits (164), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 96/345 (27%), Positives = 139/345 (40%), Gaps = 67/345 (19%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWG--GVVFKTIGFFIAN----EVSP 59 L+ T GV+FP P L++ ++ A + WG G + IG A+ +P Sbjct: 49 LASTVFGVRFPAPLGLAAG-----FDKDGTALSS-WGAMGFGYAEIGTVTAHPQPGNPAP 102 Query: 60 RFDHLVKEDTGF--IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI----MGENE 113 R L + +GF N H L R + + P V I G+ Sbjct: 103 RLFRLADDRALLNRMGFNN------HGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAV 156 Query: 114 QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 + AR+V A + N S P G Q+ E + AV+ ++ P+L Sbjct: 157 NDYRASARMVGPL-ASYLVVNVSSPNTP----GLRDLQAVESLRPILSAVRAETSTPVLV 211 Query: 174 KMTPN--------IGDMC-EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVN--G 222 K+ P+ I D+ E+ LA GI A NT S + P V+ G Sbjct: 212 KIAPDLSDSDLDDIADLAVELDLA-------GIVATNTTVS------RDGLTTPGVDRLG 258 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRD-----FPISGIGGIETWEDAAEFLLLGAA 277 ISG P+A R +Q +R L D + +GGIET +DA E + GA+ Sbjct: 259 PGGISG------PPLAQRAVQVLR---RLYDRVGDRLALISVGGIETADDAWERITAGAS 309 Query: 278 TLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 LQ TG + G R +D+ G++ L D GF SL E VG A Sbjct: 310 LLQGYTGFIYGGERWAKDIHEGIARRLHDGGFGSLHEAVGSARRR 354 >UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14 Tax=Drosophila RepID=PYRD_DROME Length = 405 Score = 67.8 bits (164), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 82/337 (24%), Positives = 145/337 (43%), Gaps = 31/337 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 ++L +F G NP +++ N E D G+G + T+ A E +P+ Sbjct: 84 QNLHTSFFGRMLSNPIGIAAGFDKNA-EAVDGLQDLGFGFIEVGTVTP-AAQEGNPKPRV 141 Query: 64 L-VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + ED I + + L LR+ KE++ ++ +G N+ +A Sbjct: 142 FRLTEDKAIINRYGFNSDGHQAVLQRLRLLRK-KENFNG--VVGVNLGRNKTTMSPIADY 198 Query: 123 VQEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC---RAVKRGSTLPMLAK 174 VQ AD + N S P + EL+E+ ++ + +P+L K Sbjct: 199 VQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLK 258 Query: 175 MTPNIG--DMCEVALAAKRGGA--DGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 ++P++ DM ++ KR + DG+ NT S NI+ N+ G S Sbjct: 259 LSPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKL--------AEETGGLS 310 Query: 231 GKAVKPIALRFIQQMRTHPELRD--FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 G +K + I QM +L D PI G+GG+ + DA E + GA+ +Q+ T ++ Sbjct: 311 GPPLKARSTEMIAQMY---QLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYE 367 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVP 325 G +VED+ + LS + G ++ ++VG + +P Sbjct: 368 GPALVEDIKAELSALITRLGHTNVADVVGTNSKFYLP 404 >UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FBL7_SACEN Length = 338 Score = 66.6 bits (161), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/193 (32%), Positives = 94/193 (48%), Gaps = 31/193 (16%) Query: 95 LKEDYPD---KVLIASIMGENEQQWEELARLVQEA--GADM--IECNFSCPQMTSHAMGS 147 L++ YP + I S+ G + +++ L + +A D+ +E N SC H + Sbjct: 124 LRDYYPRTRGQNTIISVGGFSAEEFVTLIDKINDAVPAGDIAAVEFNVSC-----HNVNF 178 Query: 148 DVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSIT 207 D E V AV R S P++ K++P+ + LAAK G + AINTVK + Sbjct: 179 DFNAIIESV--LAEAVPR-SAHPVILKLSPDYDYLAHARLAAKHG-VSALTAINTVKGLR 234 Query: 208 NIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRD----FPISGIGGIE 263 L+ + G P++ K+ G SG+A+KPI LR + ELRD PI GGI Sbjct: 235 ---LDPETGQPLL--KNRFGGLSGRAIKPIGLRVVA------ELRDAGVKLPIIATGGIR 283 Query: 264 TWEDAAEFLLLGA 276 T++D E+ GA Sbjct: 284 TFDDCREYFWAGA 296 >UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family protein n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31DA9 Length = 303 Score = 65.9 bits (159), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 133/299 (44%), Gaps = 44/299 (14%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF--FIANEVS 58 M L +FCG++ +P V A A +G + + F F++ V+ Sbjct: 1 MSAPSLPTSFCGIELAHPI------VNGSGTFDAIAAQRAFGDALVEQFPFAAFVSKTVT 54 Query: 59 ---------PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM 109 PR L IG N + +A + L +L L RL LI ++M Sbjct: 55 VAPREGNPPPRLWELPAGLINSIGLPN-KGLAGY-LTHDLPELARLPVP-----LIVNVM 107 Query: 110 GENEQQWEELARLV----QEAGADMIECNFSCPQM-TSHAMGSDVGQSPELVEKYCRAVK 164 G EE+A+LV + +E N SCP + T MGSD ++ LVE+ V+ Sbjct: 108 GFTR---EEVAQLVTAFAERDEVAALELNVSCPNVETGTIMGSDPTETARLVER----VR 160 Query: 165 RGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 + P++ K+TPN D VA AA+ GADG++ INT++ + L+ + P + + Sbjct: 161 PLTQKPIVVKLTPNASDPGAVAEAAEAAGADGLSLINTIRGMA---LDPRTREPWLGAGT 217 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 G SG V+ +AL Q+ + P+ +GG++ DA + L GA + V T Sbjct: 218 --GGVSGATVRAVAL---AQVSDVAQRVSIPLIAMGGVQRGRDADDLLRAGATLVAVGT 271 >UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_ANASP Length = 343 Score = 64.7 bits (156), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 67/325 (20%), Positives = 140/325 (43%), Gaps = 35/325 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF---IANEVSPRF 61 DL+ + G++ +P S+SP+ + D G VV ++ F ++ E Sbjct: 2 DLTTNYLGLRLRSPLVPSASPMSGEIDNILWMEDAGAAAVVLPSL--FEEQLSLESYELH 59 Query: 62 DHLVKEDTGFIGFKNMEQIAEHP-----LEENLAALRRLKEDYPDKVLIASIMGENEQQW 116 HL F +++ EH EE L +++ KE + IAS+ G + W Sbjct: 60 HHLTYGTESFP--ESLTYFPEHQDFRLGSEEYLNLIQKTKEKVKIPI-IASLNGSSLDGW 116 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK----YCRAVKRGSTLPML 172 E AR++++AGA +E N ++++ +D + E +E+ + VK +P+ Sbjct: 117 TEYARMIEQAGAAALELN-------TYSVHTDPELTSEQIEQSYINMLKVVKASVQIPVA 169 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 K++P +M +A GAD + N I + + + + + + Sbjct: 170 IKLSPYFTNMANMAKRLDDAGADALVLFNRF-------YQPDINLETLEVQPHVLLSTPQ 222 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 A++ + LR+I + H ++ GI D + L+ GA + + ++++G Sbjct: 223 AMR-LPLRWIAILYGHINAH---LAATSGIHNGHDVLKMLMAGANITMLCSVLLRHGIDH 278 Query: 293 VEDMASGLSHYLADQGFDSLQEMVG 317 + + +S ++ ++S+Q++ G Sbjct: 279 IRCIEQEMSQWMEKHEYESVQQLQG 303 >UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVY1_9BACT Length = 325 Score = 64.7 bits (156), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 83/323 (25%), Positives = 137/323 (42%), Gaps = 37/323 (11%) Query: 10 FCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDT 69 + G+ P+P +SSSP + + + +G G VV K+I ++ H DT Sbjct: 5 YLGLDLPSPIIVSSSPYTSNVKSVEQCAASGAGAVVLKSI---FEEQI---LHHAAALDT 58 Query: 70 -GFIGFKNMEQIAEHPLEENL-AALRRLKEDYPDKVLIASIMGEN----EQQWEELARLV 123 + + E + L E+ A RL ++ K + I N + W E A + Sbjct: 59 VSDSAYGDAEVYLQRYLGEDYKAGFLRLVQEARSKTELPVIASINCVVDKGDWIEYATAM 118 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQS-PELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 +AGA +E N HA ++ + E+V + AVK +P+ K+ + ++ Sbjct: 119 ADAGASALELNIFIQSTDIHAQARELELNYAEIVGRVAGAVK----IPVSVKLPMRLTNV 174 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 ++ A GA G+ N ++D+ + M V S YS +P LR + Sbjct: 175 FALSSALLGHGARGVVFFNRFFE-PDVDVER---MTFVES----SPYS----EPTELRNV 222 Query: 243 QQM-----RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 +M P+L D +S G+ E A + LL GA +QV T I Q G+ ++ +M Sbjct: 223 LRMVAICSAVLPQL-DLSVS--TGVHDGEAAVKALLCGAEAVQVCTAIHQKGFEVIAEMN 279 Query: 298 SGLSHYLADQGFDSLQEMVGLAN 320 + + QGF SL E G N Sbjct: 280 EYIDRWSERQGFGSLDEFRGRLN 302 >UniRef50_Q56ZE6 Dihydroorotate dehydrogenase like protein (Fragment) n=3 Tax=Magnoliophyta RepID=Q56ZE6_ARATH Length = 116 Score = 64.3 bits (155), Expect = 7e-09, Method: Composition-based stats. Identities = 29/65 (44%), Positives = 44/65 (67%) Query: 253 DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSL 312 D +SGIGG+ET DAAEF+LLG+ T+QV TG+M +GY V+ + + L ++ F ++ Sbjct: 1 DRSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMMHGYGHVKTLCAELKDFMKQHNFSTI 60 Query: 313 QEMVG 317 +E G Sbjct: 61 EEFRG 65 >UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular organisms RepID=PYRD_BRASB Length = 364 Score = 64.3 bits (155), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 83/340 (24%), Positives = 144/340 (42%), Gaps = 39/340 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS----PRF 61 L++ G+ FPNP +++ N E+ G+G F IG S PR Sbjct: 44 LAVRAFGLNFPNPVGMAAGFDKNA-EVPDALLRLGFG---FVEIGSVTPRPQSGNPRPRL 99 Query: 62 DHLVKED--TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 L +++ +GF N + LRRL ++ +G N+ + + Sbjct: 100 FRLERDEAVVNRMGFNN---------DGAEIVLRRLAGRANQGGIVGVNVGANKDSADRV 150 Query: 120 A---RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC----RAVKRGSTLP 170 A RL++ A N S P Q EL+ K R ++ P Sbjct: 151 ADYVRLIETFAPVASYFTVNISSPNTPGLRNLQQAAQLNELLSKVLEARDRVRRKAGDTP 210 Query: 171 MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ ++ +V A+ G DG+ NT + N L +++ K G Sbjct: 211 VLLKIAPDLSLAELDDVVHVARSRGVDGMIVSNTTLARPN-SLREQL-----RAKEQ-GG 263 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG+ + ++ R + + E FP+ G+GGI++ A + GA+ +Q+ + ++ Sbjct: 264 LSGRPLFRLSTRMVAETFVRVE-GAFPLIGVGGIDSGGAALTKIRAGASLIQLYSSLVYK 322 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAED 328 G +VE + + L+ L G DSL E+VG A+ + AED Sbjct: 323 GLGLVESIKADLTSTLLRTGRDSLSEIVG-ADAATITAED 361 >UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonproteobacteria RepID=PYRD_NAUPA Length = 359 Score = 64.3 bits (155), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 66/235 (28%), Positives = 106/235 (45%), Gaps = 25/235 (10%) Query: 93 RRLKEDYPDKVLIASIMGENEQQWEELAR-----LVQEAGADMIECNFSCPQMTSHAMGS 147 +RLK+ YP + I + +G+N+ EE A LV E + + + + Sbjct: 131 KRLKKIYPFILPIGANIGKNKTTPEERAVEDYKILVNELKDVVDFFVVNVSSPNTPGLRD 190 Query: 148 DVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALA--AKRGGADGIAAINTVKS 205 + + E + +K + P+L K +P++ D + LA + GADGI NT Sbjct: 191 LL--NAEFISSLFGELKNLTDKPILIKFSPDMEDELIINLANYSVLAGADGIIVTNTT-- 246 Query: 206 ITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR--THPELRDFPISGIGGIE 263 N DL VN + G SGK P+A R + +R PI +GGI+ Sbjct: 247 -VNYDL--------VNSEIKRGGISGK---PLAQRSYEVLRIVAGEVFGKVPIISVGGID 294 Query: 264 TWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 + E+A + + GA+ LQV T I+ G IV ++ GL L G+ + E +G+ Sbjct: 295 SAEEAYKRIKAGASLLQVYTAIIYKGPGIVGEINRGLIELLKKDGYSHISEAIGV 349 >UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flavoviridis RepID=B9UIZ1_9ACTO Length = 326 Score = 63.9 bits (154), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 73/297 (24%), Positives = 116/297 (39%), Gaps = 37/297 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L + G+ NP + S + + + G G VV KTI + R L Sbjct: 31 LEVPILGLSPANPVIVGSGLLTDQERNIRRLLGKGAGAVVTKTIHPSPPQGLDERILRLP 90 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 +G N ++ + L LR +D +IAS+ + + LA+ V+ Sbjct: 91 ------VGMLNSTTYSKRSVNRWLKTLRSFADDR--LPVIASLHADTPGELAMLAKDVET 142 Query: 126 AGADMIECNFSCPQMTSHAMGSDVG---QSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 G +E SC + + G +P+ V Y V+ + LPM K+ G Sbjct: 143 TGCRALELGISC-------LNEEDGLEDDNPDRVYAYTSEVRSKTALPMSVKLAVGEGLR 195 Query: 183 CEVALAAKRGG-----ADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 V A G +D IA + ++LN + GYSG +KP+ Sbjct: 196 DRVRAAIAGGADAITLSDTIAGAAVSPTTGRLELN------------GVFGYSGPGLKPL 243 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 L I Q+R P+ G GG+ + D A++L +GA+ QV T + YR +E Sbjct: 244 VLAAIWQLRKSGIA--LPVMGCGGVSSGRDVADYLSVGASVAQVYTALHTDMYRTLE 298 >UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobacteria RepID=Q1GGD3_SILST Length = 352 Score = 63.9 bits (154), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 85/335 (25%), Positives = 133/335 (39%), Gaps = 56/335 (16%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN----EVSPRF 61 L G+ PNP L++ N E A + G+G F +G PR Sbjct: 44 LRTDVAGLSLPNPVGLAAGFDKNA-EALAPLSEAGFG---FIEVGAATPRPQPGNPKPRL 99 Query: 62 DHLVKEDTGFI---GFKN--MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN---E 113 L ED I GF N M+ I +RL + P +I +G N E Sbjct: 100 FRL-SEDRAAINRFGFNNEGMDTIG-----------KRLAQ-RPKSGVIGLNLGANKDSE 146 Query: 114 QQWEELARLVQEAGA--DMIECNFSCPQMTS-------HAMGSDVGQSPELVEKYCRAVK 164 + ++ AR++ GA D N S P A+ S + + E R + Sbjct: 147 DRAQDFARVLSHCGAHLDFATVNVSSPNTEKLRDLQGKDALASLLAGVIDAREALQRPI- 205 Query: 165 RGSTLPMLAKMTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 P+ K+ P+ I + ++A A+ G D + A NT S + + Sbjct: 206 -----PVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNTTLSRDGLKSTHR-------- 252 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 + G SG + + R + Q+ + PI G+GGI T E A + GA+ +Q+ Sbjct: 253 -DEMGGLSGAPLFERSTRVLAQLSQRLD-GAVPIIGVGGISTAEGAYAKIRAGASAVQLY 310 Query: 283 TGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 T ++ G + ++ASGL LA GF ++ E VG Sbjct: 311 TALVYGGLSLASEVASGLDALLARDGFSNVAEAVG 345 >UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydroorotate oxidase n=1 Tax=Streptococcus mutans NN2025 RepID=C6SRR7_STRMN Length = 330 Score = 63.9 bits (154), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 56/235 (23%), Positives = 107/235 (45%), Gaps = 11/235 (4%) Query: 89 LAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGAD-MIECNFSCPQMTSHAMGS 147 L + L++ K S++G + ++ + ++V+ + ++E N SCP + Sbjct: 101 LDYVTELQKQPDSKNHFLSLVGMSPEETHTILKMVEASKYQGLVELNLSCPNVPGKP--- 157 Query: 148 DVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSIT 207 + E ++ V T P+ K+ P D+ AA + +N + SI Sbjct: 158 QIAYDFETTDQILSEVFTYFTKPLGIKLPPYF-DIVHFDQAAAIFNKYPLTFVNCINSIG 216 Query: 208 NIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM--RTHPELRDFPISGIGGIETW 265 N L + ++ K+ G G VKP AL + R +P ++ I G GG++T Sbjct: 217 N-GLVIEDETVVIKPKNGFGGIGGDYVKPTALANVHAFYKRLNPSIQ---IIGTGGVKTG 272 Query: 266 EDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 DA E +L GA+ +Q+ T + Q G +I + + L + ++G+++L++ G N Sbjct: 273 RDAFEHILCGASMVQIGTALHQEGPQIFKRITKELKAIMTEKGYETLEDFRGKLN 327 >UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=candidate division TM7 RepID=UPI00016B255A Length = 394 Score = 63.5 bits (153), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/206 (29%), Positives = 97/206 (47%), Gaps = 17/206 (8%) Query: 118 ELARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 E LV +G A +E N SCP + + + + L+ + K + +P+ KM Sbjct: 193 EAMSLVSGSGLAKAVEINISCPNIDDNQPFTYPDKLDNLLSQLD---KINADMPIFIKM- 248 Query: 177 PNIGDMCEVALAAK---RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 PN+ D L + + +G+ N VK +NI+L K+ +S G SGK Sbjct: 249 PNLVDFVRFGLILEIISKHKINGVTISNLVKDRSNINLKDKLP------ESVKGGLSGKP 302 Query: 234 VKPIALRFIQQMRTHPELRD-FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + +L I+ T+ + D I G+GGI EDA + G++ + + TG+M G ++ Sbjct: 303 CRDRSLDLIKF--TYEKYGDRLLIIGVGGIFNAEDAYLKIRAGSSLVALITGLMFEGPQM 360 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGL 318 V D+ GL L GF SL E +G+ Sbjct: 361 VGDINHGLDKLLKRDGFSSLTEAIGI 386 >UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5YA20_COPPD Length = 274 Score = 63.2 bits (152), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 114/277 (41%), Gaps = 40/277 (14%) Query: 17 NPFCLSSSPVGNC-YEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGF---I 72 NPF SS G C Y +G V KTI P LV+ G I Sbjct: 14 NPFIASS---GTCGYADADLIPLDKFGAAVTKTITLLPRQGNRP--PRLVETPAGLVNSI 68 Query: 73 GFKNMEQIAEHPLEENLAALRRLKEDYPD-KVLIASIMGENEQQWEELARLVQEAGA--- 128 G +NM L A ++ D+ LI S+ GE+ E+ A +V+E Sbjct: 69 GLQNM----------GLEAFKQFLTDFKKPTTLIVSVGGESP---EDFATIVEELNTYDL 115 Query: 129 -DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 D E N SCP + + G VG+ V A + +T P+L K++P + + L Sbjct: 116 IDAFELNLSCPNVKTG--GEVVGKDYVTVSNILEASLKSTTKPLLVKLSP-FTEQLDKIL 172 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 + NT + +D++ + G P++ S G SG A+ PI L I + Sbjct: 173 QHWESKVEAFVLFNTFPA---MDIDPRSGKPVLGAVS--GGLSGPAIYPIVLNSIYKYS- 226 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 + + GGI T + A +F++ GA L++ TG Sbjct: 227 ----KAHTLVASGGIATTDIAKKFIMAGARALEIGTG 259 >UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacteria RepID=B7K1Y7_CYAP8 Length = 339 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/234 (23%), Positives = 107/234 (45%), Gaps = 19/234 (8%) Query: 86 EENLAALRRLKE--DYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSH 143 +E L +R+ KE D P +I S+ G W + A+ +Q+AGAD +E N Sbjct: 88 QEYLNHIRQAKEMVDIP---IIGSLNGSTLGGWLDYAQQIQQAGADALELNIYYVPTDLD 144 Query: 144 AMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTV 203 G +V Q+ + VK +P+ K++P +M +A GADGI N Sbjct: 145 IPGGEVEQN---YLDILKNVKAALNIPVAIKISPYFSNMANMAKRLAEAGADGIVLFNRF 201 Query: 204 KSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIE 263 +IDL P ++ + +A++ + +R+I + E ++ GI Sbjct: 202 YQ-PDIDLENLEVYP------NVLLSTPQALR-LPMRWIAILYGRIEAD---LAATSGIH 250 Query: 264 TWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 D + +++GA QV + ++++G + + G+ ++ D ++S+++M G Sbjct: 251 HTTDVLKMVMVGAKITQVVSALLRHGIGYLSTLEQGMIRWMEDNEYESIKQMQG 304 >UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteriaceae RepID=D2S350_9EURY Length = 356 Score = 62.4 bits (150), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 84/336 (25%), Positives = 138/336 (41%), Gaps = 58/336 (17%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN-EVSPRFDHL 64 L + FPNP +++ N E+ G+G V T+ + PR L Sbjct: 51 LEVDLFDSTFPNPVGIAAGFDKNA-EVTHALEALGFGFVEIGTVTPYPQEGNDRPRLFRL 109 Query: 65 VKEDTGFI---GF--KNMEQIAEHPLEENLAALRRLKED----YPDKVLIASIMGENEQQ 115 +ED G I GF + ME + E RL+ED +P V I + E++ Sbjct: 110 -REDEGMINRMGFNGQGMETVKE-----------RLEEDGTPGFPLGVNIGKMNSSTERE 157 Query: 116 W-EELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV------KRG 166 E+ R+ AD + N SCP + SPE + RA+ + Sbjct: 158 AIEDYRRVFDRVSPFADYVVVNVSCPNTPDEFNEA----SPE----HLRAIFETLEAEND 209 Query: 167 STLPMLAKMTPN-----IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVN 221 +PML K+ P+ I D+ ++ + G DGI A NT + ++ Sbjct: 210 GNVPMLVKIGPDEPEDAILDLVDIV---QEFGLDGIVATNTSTAREGLE---------SP 257 Query: 222 GKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 + G SG ++ + I+ + H + + PI G+GG+++ A E + GA+ +Q+ Sbjct: 258 AREEWGGLSGAPIEDRSTDVIRTIAGHTD-GELPIVGVGGVDSAASAYEKIRAGASLVQL 316 Query: 282 TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 TG + G + GL L GF S+++ VG Sbjct: 317 YTGFVYRGPSTAGRINQGLVDLLERDGFSSVEDAVG 352 >UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotogaceae RepID=PYRD_THEP1 Length = 270 Score = 62.4 bits (150), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 75/277 (27%), Positives = 127/277 (45%), Gaps = 37/277 (13%) Query: 18 PFCLSSSPVGNCYEMCAKAYDTGW-GGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKN 76 P L S P G + K D + GGV+ KT+ E +P + D I Sbjct: 7 PLVLLSGPAG--FGEYLKLMDHRYVGGVLLKTVTLH-PKEGNPT-PRMADSDFYVINRIG 62 Query: 77 MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADM--IECN 134 +E H EN+ L P +IAS+ G++ +++ E+AR+ ++ +E N Sbjct: 63 LENPGIHAFVENIPEL-----PVP---MIASLGGDSFEEYLEVARVFKKVADRFYAVEFN 114 Query: 135 FSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP---MLAKMTPNIGDMCEVALAAKR 191 FSCP + G + ++ E +K +++ LP ++AK+ + + A + Sbjct: 115 FSCPNVKEG--GLSIVKNAEEWKKLLNTLRK--ELPDSFLIAKVGVEGIFVEDAAEFVMK 170 Query: 192 GGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH-PE 250 G DGI +NTV+ G+ + G SG +KPIALR + +++ PE Sbjct: 171 TGWDGITLVNTVR-----------GLHFEKDTMILGGLSGPVLKPIALRAVYEVKKRFPE 219 Query: 251 LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 L F I+ GG+ + +DA EFL +GA + V + + + Sbjct: 220 L--FVIAS-GGVYSVKDAEEFLKVGADVIGVGSALFK 253 >UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36786 Length = 307 Score = 61.2 bits (147), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 82/315 (26%), Positives = 145/315 (46%), Gaps = 32/315 (10%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFI 72 + NP +++ +GN E A+ +D G + FI + + K + GFI Sbjct: 14 IHLKNPLMPAAATLGNLIEH-ARYFDLNELGAMMPN-SMFIDSGSPTMAKKICKTNNGFI 71 Query: 73 GFKNMEQIAEHPLEENLAALRRLK-EDYPDKVLIASIMGENEQQWEELARLVQEAGADM- 130 + ++ E+ + L L E P LI + ++ Q EELA +++ M Sbjct: 72 SALSKNNMSIFEFEKEI--LPHLPCETTP---LIIDMKAVDKYQMEELAASIEQMDRIMG 126 Query: 131 IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC--EVALA 188 IE N +CP + G+ ++P+ ++ V+ + L P GD+ E+++A Sbjct: 127 IEINLNCP----YGPGTPYWKNPDELKDLVARVRAAAPHKWLIAKVPG-GDIPVEEISVA 181 Query: 189 AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH 248 + GGAD AI + S+ ++ + G G G+SG A KP+ + ++ T Sbjct: 182 CQEGGAD---AITSYSSLNGSCIDIRTGT-YRCGGGGSGGFSGPAFKPVGILMCRRAATA 237 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ---YGYRIVEDMASGLSHYLA 305 D P+ GIGGI ED E+++ GA +QV + + + +R+++D+ + LA Sbjct: 238 ---VDIPVIGIGGISCAEDVIEYIMAGAYAVQVGSANLSRPDFMHRLLKDLEA-----LA 289 Query: 306 DQ-GFDSLQEMVGLA 319 Q G SL+E+ G A Sbjct: 290 GQMGISSLEEIRGTA 304 >UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Culicini RepID=B0W4C3_CULQU Length = 397 Score = 60.8 bits (146), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 107/238 (44%), Gaps = 21/238 (8%) Query: 92 LRRLKEDYPDKVLIASIMGENEQQWEELARLVQ-----EAGADMIECNFSCPQMTS-HAM 145 +++L++D KV + +G N++ + + VQ AD + N S P M Sbjct: 162 IKKLRQDGDLKVTLGINLGRNKKSEDNIEDYVQGIRKFSVLADYLVVNISSPNTPGLRTM 221 Query: 146 GSDVGQSPELVE--KYCRAVKRGSTLPMLAKMTPNIGDMCEVALAA----KRGGADGIAA 199 + L E K A+ P+L K+ P++ D C + A K DG+ Sbjct: 222 QNKSTLQSLLTEIVKARNALPPNEQRPILVKIAPDLSDGCVQEIIAVIQKKECAIDGLI- 280 Query: 200 INTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGI 259 ++N +++ + +N + G SG + + + + ++ R PI G+ Sbjct: 281 ------VSNTTIDRPSELKSINA-GQLGGLSGAPLSSKSTQLVAKVYKWTGGR-VPIIGV 332 Query: 260 GGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 GGI + DA E +L GA+ +Q+ T ++ +G IV + L L + G++++Q+ VG Sbjct: 333 GGIFSGRDAYEKILAGASAVQLYTALIYHGPPIVARVKEELGQLLKENGYENVQQAVG 390 >UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_SYNY3 Length = 381 Score = 60.8 bits (146), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 51/156 (32%), Positives = 72/156 (46%), Gaps = 14/156 (8%) Query: 170 PMLAKMTPNIGDMCEVALAA-----KRGGADGIAAINTV--KSITNIDLNQKIGMPIVNG 222 P+L K++P D+ A+A K GI A NT +S + + G PI Sbjct: 225 PLLVKISP---DLSWEAIAVIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPIEQE 281 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 +SG + +R+I Q PI G+GGI T EDA E + GA+ LQ+ Sbjct: 282 AGGLSGQPIRDRATEVIRYIYQQTGG----TIPIIGVGGIFTAEDAWEKIQAGASFLQIY 337 Query: 283 TGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 TG + G +V D+ GL LA GF + E VG+ Sbjct: 338 TGWIYGGPWVVSDILQGLGEKLAAGGFSHISEAVGI 373 >UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobacterales RepID=PYRD_SULDN Length = 352 Score = 60.8 bits (146), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 57/239 (23%), Positives = 108/239 (45%), Gaps = 27/239 (11%) Query: 89 LAALRRLKEDYPDKVLIASIMGENE--------QQWEELARLVQEAGADMIECNFSCPQM 140 L+A +RLK+ +P I +G+N+ + L + + E G D + N S P Sbjct: 127 LSAQKRLKKRFPFTTPIGINIGKNKLTPDTQAINDYTTLIKALHELG-DYLVINISSP-- 183 Query: 141 TSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALA--AKRGGADGIA 198 + G Q+ E + K K ++ P+L K+ P++ VAL A GADGI Sbjct: 184 --NTPGLRDLQNEEFITKLFEESKAITSKPILLKIAPDMSKEDAVALTKLAVLKGADGII 241 Query: 199 AINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISG 258 A NT + +V SI G SG +K + + + + IS Sbjct: 242 ATNTT-----------VDYSLVKEPKSIGGLSGAVLKEKSFEIFEAVAKELYGKTTLIS- 289 Query: 259 IGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 +GGI + ++ + GA+ +Q+ +G++ G +++++ + L+ + G+ ++ + +G Sbjct: 290 VGGISSAKEVYRRIKAGASLVQIYSGLIYEGPDLIKNINNELTELIKADGYTNITQAIG 348 >UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria RepID=B8G4M8_CHLAD Length = 355 Score = 60.5 bits (145), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 69/320 (21%), Positives = 135/320 (42%), Gaps = 24/320 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS T+ G+K P ++SP+ E+ + + G G VV ++ + S D + Sbjct: 3 DLSTTYLGMKLRTPIVAAASPISRNVELVRQLEEAGLGAVVMYSLFEEQIIQQSLELDRM 62 Query: 65 VKEDTGFIGFKNMEQIAEH------PLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + + + EH P E L + LK+ V I S+ G ++ W Sbjct: 63 LSHGAESFA-EALSYLPEHGAYSTGP-ERYLEQVAALKQGLSIPV-IGSLNGVSKGGWVH 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 ARL+QEAGAD +E N + ++ S++ ++ +AV+ ++P+ K+ P Sbjct: 120 YARLIQEAGADALELNIYFVPIDTNITSSEL---EDIYVDLVKAVRAEISIPLAVKIGPY 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + A GA+ + N + DL Q P + +S A ++ Sbjct: 177 FTALPNFAWRLMEAGANALVLFNRFYQ-PDFDLEQLSVRPNLQLSTS-------AELRLS 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ-YGYRIVEDMA 297 LR+I + L +F +S G+ D + L+ GA + + ++ ++ + Sbjct: 229 LRWIALLYGRIPL-EFALS--SGVHNAIDVLKGLMAGANVTMIASAFLRGRATDVLRTIL 285 Query: 298 SGLSHYLADQGFDSLQEMVG 317 + +L + ++S+ ++ G Sbjct: 286 HDMELWLTEHEYESIAQLHG 305 >UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 Tax=Saccharomycetales RepID=PYRD_ASHGO Length = 444 Score = 60.5 bits (145), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 62/235 (26%), Positives = 110/235 (46%), Gaps = 22/235 (9%) Query: 99 YPDKVLIASI-MGENEQQWEELARLVQ--EAGADMIECNFSCPQMTSHAMGSDVGQSPEL 155 Y DK+L ++ +N + E+ R V+ ++ AD++ N S P G+ EL Sbjct: 212 YKDKLLGINLGKNKNGDEVEDYLRGVEKFQSLADVLVINVSSPNTPGLRDLQQEGRLTEL 271 Query: 156 ----VEKYCRAVKRGSTL-------PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINT 202 V K + G+ L P+L K+ P++ + + +A AAK+ DGI NT Sbjct: 272 LSMIVAKRNSLINEGNVLGASTHKPPVLVKIAPDLTEPELQSIAEAAKKSSIDGIIVSNT 331 Query: 203 VKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGI 262 +I D + + K+ G SGK VKP AL+ ++ + + + + + G GGI Sbjct: 332 --TIQRPDSLYTVDEEL---KNQAGGLSGKPVKPFALKALRTIHQYTKDTNLVLVGCGGI 386 Query: 263 ETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + +DA EF GA +Q+ T G ++ + ++ L ++G + E++G Sbjct: 387 SSGQDAIEFAKAGAHFVQLYTAYAYRGPGLIARIKDEVTEELRNEG-KTWMEIIG 440 >UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5A0_9ALVE Length = 471 Score = 60.5 bits (145), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 94/207 (45%), Gaps = 26/207 (12%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV---KRGS--TLPMLAKMTPNIGD- 181 A I+ N SCP D+ E +EK A+ +R + P+L K++P + Sbjct: 268 AAYIDVNISCPNTAEGKTFEDL----EALEKLLGALLTWRRDNYPDKPVLVKLSPPPAEA 323 Query: 182 -------MCEVALAAKRGGADGIAAINTVKSI-TNIDLNQKIGMPIVNGKSSISGYSGKA 233 + + A G DG INT+ +++L++ +G K ISG Sbjct: 324 DDTYYEGVSRMVRKAVELGVDGFVMINTIADRGDDLNLDRSVGDSNHGEKGGISG----- 378 Query: 234 VKPIALRFIQQMRTHPELR--DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 KP+ R I +R ++ PI G GG+ T +DA + GA+ +QV TG++ G Sbjct: 379 -KPVRQRAINLVRHVYKVTAGKVPIIGCGGVFTAQDAYRLIRNGASLIQVYTGMIYEGPW 437 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGL 318 + D+ GL+ L G+ ++ E VG+ Sbjct: 438 VFRDINCGLAELLRKDGYSNVHEAVGV 464 >UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UHA6_RHOBA Length = 359 Score = 60.1 bits (144), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/323 (20%), Positives = 135/323 (41%), Gaps = 35/323 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + +L ++ G++ +P + + P+ E + G G +V +I + +V R Sbjct: 13 MPSELITSYLGMQLESPVVMGACPLTTQSEAVRQIVAAGAGAIVLPSI---LQEQVMHR- 68 Query: 62 DHLVKEDTGF-----IGFKNMEQIAEHPLEENLAALRRLKE--DYPDKVLIASIMGENEQ 114 ++K F G++ + E L + RLK P +IAS+ G + Sbjct: 69 --MIKATDPFGAIERSGYQPQQDKYNGGTEAYLRTISRLKGICSVP---VIASMNGSSAG 123 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC---RAVKRGSTLPM 171 QW + A+ ++ AGAD +E N S +D+ + C R V+ +P+ Sbjct: 124 QWLQYAKEMESAGADALEFNLQQAVFDSKETSNDIE------ARMCDLIRQVRELVVIPV 177 Query: 172 LAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 AK++ ++ +A ++ G G+ + D++ +N + S + G Sbjct: 178 AAKISQRYTNLSSMATQLRQVGVAGLVLFT---HMPQWDVSTDRMHWTINWELSPTNSIG 234 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 ++ I +R + I+ GG+ EDA + ++ GA + VT+ + + G Sbjct: 235 GILEGI-------VRARAGDQAISIAASGGVSNSEDAIKAMIAGADVVMVTSAVYRRGPD 287 Query: 292 IVEDMASGLSHYLADQGFDSLQE 314 + D+ G+ ++ F +LQ+ Sbjct: 288 AIRDIVDGIERHVESSRFRTLQD 310 >UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae RepID=Q2S001_SALRD Length = 366 Score = 60.1 bits (144), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 94/349 (26%), Positives = 132/349 (37%), Gaps = 69/349 (19%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS------- 58 L G FPNP L++ N + W V F GF VS Sbjct: 47 LKQRLWGDTFPNPVGLAAGADKNARAVPF------WEAVGF---GFVEVGSVSAQPAPGN 97 Query: 59 --PRFDHLVKEDT--GFIGFKN--MEQIA---EH-------PLEENLAALRRLKEDYPDK 102 PR L K+ +G N E +A EH PL NLA K PD Sbjct: 98 PTPRAFRLPKDQALINRLGLNNDGAEAVADRLEHSRSDRARPLGINLA-----KTHDPD- 151 Query: 103 VLIASIMGEN--EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC 160 IMGE E +LV +A D + N SCP D L+ Sbjct: 152 -----IMGEAALEDFRTSFRQLVGQA--DYVTLNVSCPNTPDGGTFEDPAALDALLGAIT 204 Query: 161 RAVKR-GSTLPMLAKMTPNIGD-------MCEVALAAKRGGADGIAAINTVKSI----TN 208 K G +P+L K++P + D + E+ A DG A NT T+ Sbjct: 205 AEQKAPGLAVPVLVKLSPPLSDRVLFDTRLEEILAVAADHDIDGFIATNTASDRKGVETS 264 Query: 209 IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDA 268 D +IG G SG ++ A R +Q + + + PI G+GG+ E A Sbjct: 265 ADRLDEIGA---------GGLSGPPLEARATRLVQYLYRATD-GEIPIIGVGGVHDAESA 314 Query: 269 AEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + GA+ +Q+ T ++ G +V + GL L+D G+ SL+ VG Sbjct: 315 YTKIRAGASLVQLYTALVYEGPGLVRRIKEGLVARLSDDGYASLENAVG 363 >UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobacterales RepID=PYRD_HELPG Length = 351 Score = 60.1 bits (144), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 78/319 (24%), Positives = 132/319 (41%), Gaps = 40/319 (12%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAK-AYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED-T 69 G+ FPNP L++ N + A A+ G+ T + NE F H+ +E Sbjct: 56 GLNFPNPLGLAAGFDKNASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQ 115 Query: 70 GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGAD 129 +GF N + L A R P K I +G+N+ E A +++ A Sbjct: 116 NAMGFNNYGAV--------LGA-RSFNRFAPYKTPIGINLGKNKHI--EQAHALEDYKAV 164 Query: 130 MIEC---------NFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN-- 178 + +C N S P + D+ + E +C A K + P+ K+ P+ Sbjct: 165 LNQCLNIGDYYTFNLSSPNTPNL---RDLQNKAFVNELFCMA-KEMTHKPLFLKIAPDLE 220 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I DM E+ +A GA GI A NT I +V + G SGK + + Sbjct: 221 IDDMLEIVNSAIEAGAHGIIATNTT-----------IDKSLVFAPKEMGGLSGKCLTKKS 269 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +++ + +S +GGI ++A E + +GA+ LQ+ + + G + +++ Sbjct: 270 REVFKELAKAFFNKSVLVS-VGGISDAKEAYERIKMGASLLQIYSAFIYNGPNLCQNILK 328 Query: 299 GLSHYLADQGFDSLQEMVG 317 L L GF S++E +G Sbjct: 329 DLVKLLQKDGFLSVKEAIG 347 >UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago maydis RepID=Q0GF37_USTMA Length = 677 Score = 59.7 bits (143), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 61/234 (26%), Positives = 105/234 (44%), Gaps = 41/234 (17%) Query: 98 DYPDKVLIASIMG--------ENEQQWEELARLVQEAG--ADMIECNFSCP------QMT 141 D P + A ++G NE+ ++ + V+ G ADMI N S P ++ Sbjct: 273 DLPRSLRPAKMLGINLGKNKTSNEESVDDYVKGVERLGPYADMIIVNVSSPNTPGLRRLQ 332 Query: 142 SHAMGSD-----VGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGA 194 + D V +VE + R + +P+L K+ P++ + + +VA AA + G Sbjct: 333 RRGVLEDLLTQVVRARDGMVESHLRFSDKKVAVPLLVKIAPDLSEEELHDVADAALKSGI 392 Query: 195 DGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELR-D 253 DG+ I+N +++ + G SG VKP+AL+ + + H L+ Sbjct: 393 DGLV-------ISNTTISRPASLRSSEHVRETGGLSGAPVKPLALKALTTV--HKRLQGK 443 Query: 254 FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 PI G GGI +DA ++ GA+ +++ T +GY+ V GL L D+ Sbjct: 444 LPIIGCGGISNGQDALDYAKAGASAIELYT---SFGYQGV-----GLPRRLKDE 489 >UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospirillum RepID=Q2W4R2_MAGSA Length = 329 Score = 59.7 bits (143), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 82/365 (22%), Positives = 151/365 (41%), Gaps = 62/365 (16%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF---IANEVSPRF 61 +L+ + G+ NP +S+SP+ + D G +V +I F I NE+ Sbjct: 2 NLATRYLGLDIKNPLVVSASPLALDLGNSRRLEDCGAAAIVLPSI--FQEDIENEID-EI 58 Query: 62 DHLVKE--DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + LV E F F I+ + +N L R + + +IAS+ G W E Sbjct: 59 ERLVCEGNSEAFSYFP--ANISANAGPKNYLDLIRRTREALEIPVIASLNGTTRTGWTEY 116 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDV-GQSPELVEKYCRAVKRGSTLPMLAKMTP- 177 A Q+AGA IE N G++V + E++E VK ++P+ K++P Sbjct: 117 AAQSQQAGASAIELNVYLLPTDMDMSGTEVESRYLEILED----VKSAVSIPVSMKLSPY 172 Query: 178 --NIGDMCEVALAAKRGGADGIAAINT----------VKSITNIDLNQK--IGMPIVNGK 223 ++G+M +V G DG+ N +K + ++ L+ K I +P++ Sbjct: 173 FSSVGNMVKVL---DDHGVDGVVLFNRFYQPDIDLDELKLVRDLKLSHKGEIRLPLL--- 226 Query: 224 SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 I+ +GK IA G++T + ++L +GA + T+ Sbjct: 227 -WIATLAGKIKASIA-------------------ASSGVQTAAEVVKYLFVGADVVMTTS 266 Query: 284 GIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDK 343 +M++G ++ + GL L ++ +S+ ++ G + R Y R+N + Sbjct: 267 ALMRHGVDYMKTLHDGLIAELKEREAESVADIRGKMSRGAT------RDLAAYDRVNYIR 320 Query: 344 CVGCG 348 + G Sbjct: 321 ILRGG 325 >UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39 Tax=cellular organisms RepID=PYRD_HUMAN Length = 395 Score = 59.3 bits (142), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 81/329 (24%), Positives = 141/329 (42%), Gaps = 33/329 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA--NEVSPRFDH 63 L + G KF NP +++ E Y G+G F IG E +PR Sbjct: 78 LEVRVLGHKFRNPVGIAAG-FDKHGEAVDGLYKMGFG---FVEIGSVTPKPQEGNPRPRV 133 Query: 64 L-VKEDTGFI---GFKNME-QIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ--- 115 + ED I GF + + EH L +L ED + + +G+N+ Sbjct: 134 FRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTED---GLPLGVNLGKNKTSVDA 190 Query: 116 WEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR---AVKRGSTLP 170 E+ A V+ G AD + N S P + L+ K + ++R Sbjct: 191 AEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPA 250 Query: 171 MLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ D ++A K G DG+ +TN +++ G+ +S G Sbjct: 251 VLVKIAPDLTSQDKEDIASVVKELGIDGLI-------VTNTTVSRPAGLQGAL-RSETGG 302 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SGK ++ ++ + I++M + R PI G+GG+ + +DA E + GA+ +Q+ T + + Sbjct: 303 LSGKPLRDLSTQTIREMYALTQGR-VPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFW 361 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVG 317 G +V + L L +QGF + + +G Sbjct: 362 GPPVVGKVKRELEALLKEQGFGGVTDAIG 390 >UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5N0_THEAS Length = 316 Score = 59.3 bits (142), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 80/318 (25%), Positives = 148/318 (46%), Gaps = 22/318 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 +++ G+ +P ++S M + + + G + T G + R + LV Sbjct: 16 VNVDLNGLGLSSPVVVAS----GVLPMDGEVWSSMEGVGLICTKGITLEPRAGNRGERLV 71 Query: 66 KEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + +G + +E + LE L L R + V +S +GE E E + R+ Sbjct: 72 ETPSGLLNSIGLENPGIDRFLEAILPDLLRSRRSLGLNVAFSS-LGELE---ELIGRIGD 127 Query: 125 EAGA-DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 A + +++E N SCP + G+ G+SPE + R + + AK+TP D+ Sbjct: 128 RAASVEVLELNLSCPNVDRE--GAVWGESPERTFEAVRLARSLWPRSVWAKLTPQAPDVA 185 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 VA AA+ GA + NT +++ + G P+ K ++G SG AV P+ LR + Sbjct: 186 AVARAAEEAGAHCLVVANT---WLGAEVDLEAGAPVF--KRVVAGLSGPAVLPLTLRLLF 240 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q+ +P++ P+ GGI + +DA + ++ GA+ +QV T + + ++ G+ + Sbjct: 241 QL--YPKV-SVPLVACGGICSPQDALKAMMAGASAVQVGTQLFR-DLGCCGEILEGIRSF 296 Query: 304 LADQGFDSLQEMVGLANN 321 L +G S+ +VG A+ Sbjct: 297 LDSRGL-SVSRLVGCAHR 313 >UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular organisms RepID=PYRD_NATPD Length = 350 Score = 59.3 bits (142), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 92/201 (45%), Gaps = 31/201 (15%) Query: 127 GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC--E 184 G D N S P + G QS + +E ++ P+L K++P++ D + Sbjct: 170 GGDYFVVNVSSP----NTPGLRELQSRDRLESILGTLQDDGASPLLVKLSPDLTDAAIED 225 Query: 185 VALAAKRGGADGIAAINTVK----SITNIDLNQKIGM---PIVNGKSSISGYSGKAVKPI 237 + G DGI A NT S+ + +++ G+ PI + + I Sbjct: 226 AIEVVEDLGLDGIIATNTTTKRPASLHSDAADEEGGLSGAPITDESTDI----------- 274 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 +RFI + RT D PI G+GGI+ E A E + GA+ +Q+ TG++ G I D+ Sbjct: 275 -VRFIAK-RT-----DKPIVGVGGIDDAESAYEKIRNGASVVQLYTGLVYEGPTIARDIN 327 Query: 298 SGLSHYLADQGFDSLQEMVGL 318 GL L GF S+++ VG+ Sbjct: 328 RGLLKLLERDGFASVEDAVGV 348 >UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBI0_BLASB Length = 320 Score = 58.9 bits (141), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 106/236 (44%), Gaps = 16/236 (6%) Query: 92 LRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGAD----MIECNFSCPQMTSHAMGS 147 L L+E K + SI G EE+ L+++A IE N SCP + +G Sbjct: 93 LNFLEEKKTKKPVFLSISG---LSIEEIFFLLKKANFSSKITAIELNLSCPNLQEEILGY 149 Query: 148 DVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKS 205 D+ + + +E + ++ P+ K+ P + + ++L + + IN++ + Sbjct: 150 DLYKIYDFLENVFKFNEK----PLGIKLPPYFKEEYIKNMSLILNQFPIVFVTCINSLPN 205 Query: 206 ITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETW 265 +D + ++ ++ G G +KP AL I++ T+ +D I G GGI Sbjct: 206 GIFVDPRNETS--VIQPRNGFGGIGGSIIKPFALANIRKFYTYLR-KDISIIGCGGISYG 262 Query: 266 EDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 +D E +L GA+ +Q+ T +M+ G + E + + +L + + S+ G N Sbjct: 263 KDIFEHILCGASAVQIGTQLMKEGISVFERLKKEFTLFLQKKNYSSINSFKGKLKN 318 >UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacter RepID=C3XDT6_9HELI Length = 357 Score = 58.9 bits (141), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 78/330 (23%), Positives = 137/330 (41%), Gaps = 33/330 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI--ANEVSP 59 + ++L+ G+ F NP L+S N E G+G + ++ NE Sbjct: 47 IHENLAQDIHGLHFYNPIGLASGFDKNA-EAVRPLASLGFGYLELGSVTQMPQDGNEKPR 105 Query: 60 RFDHLVKED-TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE- 117 F H+ +E +GF N+ L LKE YP + + +G+N+ + Sbjct: 106 MFRHVEEESLQNAMGFNNIGA---------RGMLAHLKEVYPFCIPLGINIGKNKNIAQG 156 Query: 118 ------ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 EL+ + D N S P G Q+ V++ K + P+ Sbjct: 157 DSLKNYELSLDTLKDYGDYFTFNLSSPNTP----GLRDLQNESFVKELMEMAKSTTNKPI 212 Query: 172 LAKMTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K++P+ I M V AA + G +GI A NT +ID + + P+ G Sbjct: 213 FIKISPDMEIESMLAVCDAAIQNGVNGIIATNT-----SIDYSL-VSNPVKKNDVCFGGL 266 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGKA+ + ++ + + + IS +GGI + E + LGA+ +Q+ + ++ G Sbjct: 267 SGKAISTKSKEVLRILGKNFHKKTTLIS-VGGIGDSNEVYERIKLGASLVQILSSMIYEG 325 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 ++ M + L+ L GF + E +G+A Sbjct: 326 PTLISRMNNELAEKLKADGFKHINEAIGVA 355 >UniRef50_B3EQ67 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B3EQ67_CHLPB Length = 328 Score = 58.9 bits (141), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 80/329 (24%), Positives = 131/329 (39%), Gaps = 45/329 (13%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS T+ G+K NP SS + E KA D G G VV K++ F+ Sbjct: 3 DLSTTYMGLKLKNPVIAGSSGMTESVESVTKAADAGAGAVVLKSL-----------FEEQ 51 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKE------------DYPDKVLIASIMGEN 112 + ++G+ N + EE + R + D D +IASI + Sbjct: 52 IHNESGYAIDSNEQDYYYAQAEEYIRNYTRGNDLRAYLDLISGCKDAVDIPVIASINCVS 111 Query: 113 EQQWEELARLVQEAGADMIECN-FSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 +W + A Q AGAD +E N F P D GQS ++ V ++P+ Sbjct: 112 SSEWTDFAVQAQRAGADGLELNMFMLPSDPDR----DSGQSEQVYLDVLEKVTGLISIPV 167 Query: 172 LAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDL-NQKIGMPIVNGKSSISGYS 230 AK++ + + G G+ N S +ID+ N ++ S + +S Sbjct: 168 AAKISYYFSGLANIVEKIASTGISGLVMFNRFFS-PDIDIENFEV--------KSTNVFS 218 Query: 231 GKAVKPIALRFIQQMRTHPELRDFP--ISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 ++LR++ + + P I+ GI + + LL GA Q+ + + Sbjct: 219 SPQDLSLSLRWVAMLSSR-----VPCDIAASTGIHDGKALIKQLLAGAKAGQIASVLYSE 273 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVG 317 GY ++ M L Y+ F +L EM+G Sbjct: 274 GYEVISPMLEELDAYMERHNFSTLDEMIG 302 >UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaproteobacteria RepID=PYRD_AGRT5 Length = 363 Score = 58.5 bits (140), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 84/332 (25%), Positives = 138/332 (41%), Gaps = 49/332 (14%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS----PRF 61 L T G+ FPNP +++ N E+ G+G F IG S PR Sbjct: 45 LQQTVAGLVFPNPLGMAAGYDKNA-EVPGPLLRLGFG---FTEIGTVTPRAQSGNPKPRI 100 Query: 62 DHLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 LV ED G I GF N E + AAL RL + ++ +I G N+ + Sbjct: 101 FRLV-EDEGVINRLGFNN---------EGHAAALERLTQARLRGIVGVNI-GANKDSEDR 149 Query: 119 LARLVQ-----EAGADMIECNFSCPQMTS----HAMGSDVGQSPELVEKYCRAVKR-GST 168 +A VQ A A N S P A S ++E+ +R G Sbjct: 150 IADYVQGIEAFYAVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKR 209 Query: 169 LPMLAKMTPNI-----GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK 223 +P+ K+ P++ D+ E ALA DG+ NT S + G+ + Sbjct: 210 IPIFLKIAPDLTEEGLDDVAEEALAHD---LDGLIVSNTTLS--------REGLRPGPHR 258 Query: 224 SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 G SGK + ++ + +MR + PI G+GG+ + E A E + GA +Q+ + Sbjct: 259 GEAGGLSGKPLFELSTTVLAKMRRRVGA-NLPIIGVGGVSSAETALEKVRAGADLVQLYS 317 Query: 284 GIMQYGYRIVEDMASGLSHYLADQGFDSLQEM 315 ++ G + + G+S +A +G ++++++ Sbjct: 318 CMVYEGPGLPSAIVKGMSKLVAREGVETIRDL 349 >UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus sp. RS-1 RepID=PYRD_ROSS1 Length = 361 Score = 58.5 bits (140), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 59/198 (29%), Positives = 90/198 (45%), Gaps = 21/198 (10%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG--STLPMLAKMTPN-IGDMCE 184 AD + N S P + L+ + R + R P+ K++P+ D E Sbjct: 174 ADYVAVNISSPNTPGLRRLHERAALETLLHELTR-LNRALPHPRPIALKVSPDETPDQLE 232 Query: 185 VALAAKRGGAD-GIAA-INTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 A R G D GIAA I T ++ DL+ ++ + G SG+ + A + I Sbjct: 233 ---AVVRAGCDAGIAAFIATNTTLARDDLHSRLAI-------ETGGLSGRPLTQRARQVI 282 Query: 243 QQMR--THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + TH P+ G+GGI T EDA + + GA +Q+ TG++ G I D+ GL Sbjct: 283 GAIYRLTHGAP---PVIGVGGIATAEDAYQHIRAGARLIQIYTGMVYAGPAIARDIKQGL 339 Query: 301 SHYLADQGFDSLQEMVGL 318 + L GF SL+E VG+ Sbjct: 340 ARRLRRDGFTSLEEAVGV 357 >UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9F3A8_SORC5 Length = 407 Score = 58.2 bits (139), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 56/197 (28%), Positives = 89/197 (45%), Gaps = 19/197 (9%) Query: 128 ADMIECNFSCPQMTS-HAMGSDVGQSPELVEKYCRAVKR-----GSTLPMLAKMTPNIGD 181 AD + N S P AM Q P + A+ R G+ LP+L K+ P++GD Sbjct: 206 ADFVVINVSSPNTKDLRAM-----QGPAIARALLSAIARENRAAGAPLPLLIKVAPDLGD 260 Query: 182 MCEVALAA--KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 AL A + G G+ A NT + + P G SG ++ +L Sbjct: 261 EELEALLAVVEEVGLAGVIATNTTVRRDGLATS-----PADVEAMGAGGLSGPPLRQRSL 315 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 ++++R + + G GGIE+ E A + L GA +Q+ TG + G + ++A G Sbjct: 316 AMVRRIRARLG-SNVTVIGAGGIESAEHAMDQLQAGADLVQIYTGFIYGGPLLPAEIARG 374 Query: 300 LSHYLADQGFDSLQEMV 316 LS +A G S+Q++V Sbjct: 375 LSDLVARSGARSIQDLV 391 >UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular organisms RepID=C9YAQ9_9BURK Length = 389 Score = 57.8 bits (138), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 84/331 (25%), Positives = 140/331 (42%), Gaps = 54/331 (16%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSP----- 59 D +T G++FPN +++ + A+ D G G + F GF V+P Sbjct: 77 DDPVTIAGLQFPNRVGMAAG-----LDKNARCID-GLGAMGF---GFVEVGTVTPLAQPG 127 Query: 60 ----RFDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRR--LKEDYPDKVLIASIMGE 111 R L + + +GF N H L+ +A ++R L++ +L+ +G+ Sbjct: 128 NPKPRMFRLPEANALINRLGFNN------HGLDAFIANVQRSALRQSKNPSLLLGLNIGK 181 Query: 112 NEQQWEELAR---LVQEAG----ADMIECNFSCPQ-------MTSHAMGSDVGQSPELVE 157 N E A L+ G AD I N S P + A+ + +G E E Sbjct: 182 NAATPIEKATDDYLICLDGVYPHADYITVNISSPNTKNLRSLQSDDALDALLGAIAERRE 241 Query: 158 KYCRAVKRGSTLPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSI--TNIDLNQ 213 + + K G P+ K+ P++ + +A KR G D +N + TN L++ Sbjct: 242 QLAQ--KHGQRKPVFLKIAPDLEADQVAVIAATLKRYGTDSSGKVNNAWGVIGTNTTLSR 299 Query: 214 KI--GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEF 271 GMP + G SG V + I Q+R +DFPI G+GGI + DA Sbjct: 300 GAVKGMPHA---EEMGGLSGAPVLEKSNAVIGQLRAALG-KDFPIIGVGGIMSAADAVSK 355 Query: 272 LLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + GA +Q+ TG++ G ++V+ A + + Sbjct: 356 IKAGADAVQIYTGLIYSGPQLVKGAAVAIKN 386 >UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BB63_VIBPA Length = 181 Score = 57.4 bits (137), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/146 (30%), Positives = 71/146 (48%), Gaps = 21/146 (14%) Query: 162 AVKRGSTLPMLAKMTPNIGD-----MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIG 216 A K G +P+ K+ P++ D +CE L + DG+ A NT T ++ G Sbjct: 50 AEKHGKYVPLALKIAPDLSDDEITQICESLL---KNNIDGVIATNTTLDRTVVE-----G 101 Query: 217 MPIVNGKSSISGYSGKAVKPIALRFIQQMRT-HPELRD-FPISGIGGIETWEDAAEFLLL 274 M N +SG +P+ R + +R H L D PI G+GGI+++ A E ++ Sbjct: 102 MKHANEAGGLSG------RPVQSRSTEVVRKLHEALGDKLPIIGVGGIDSYVAAKEKMMA 155 Query: 275 GAATLQVTTGIMQYGYRIVEDMASGL 300 GA +QV TG + +G +V D+ L Sbjct: 156 GAQLVQVYTGFIYHGPGLVRDIVKNL 181 >UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphylococcus RepID=Q2YWG7_STAAB Length = 354 Score = 57.4 bits (137), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 62/267 (23%), Positives = 119/267 (44%), Gaps = 23/267 (8%) Query: 59 PRFDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLI-ASIMGENEQQ 115 PR L+++D +GF N+ + + L+ LR+ P + + + M E + Sbjct: 102 PRMFRLLEDDALINRMGFNNIG------MNKALSHLRKNAYQVPVGINVGVNKMTPYEAR 155 Query: 116 WEELARLVQEAGADM--IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPML 172 +++ +++ D+ N S P + D + L + K+ T+P+ Sbjct: 156 YQDYIKVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIY 215 Query: 173 AKMTPNIG-DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+T ++ D + L A DGI NT + Q+ G+ N K G SG Sbjct: 216 LKLTSDMDFDGLKALLPAITETFDGIILANTTR--------QRDGLTSAN-KVEEGGLSG 266 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + + L+ I+ +F I G GG+ + EDA + + GA+ +Q+ + ++ G Sbjct: 267 RPLFERNLKLIKYAYQQTN-GEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLVIEGPG 325 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGL 318 + + M G++ YL D FD++ +++GL Sbjct: 326 LTKKMNKGIARYLKDHHFDNVSDILGL 352 >UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria RepID=PYRD_CHLAA Length = 363 Score = 57.0 bits (136), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 81/311 (26%), Positives = 127/311 (40%), Gaps = 49/311 (15%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 + L T CG+ FPNP L++ + + A A G+G V T+ PR Sbjct: 58 QRLQRTVCGIPFPNPVGLAAGMDKDGVAIPAWAA-LGFGFVEVGTVTHHPQPGNPRPRLF 116 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAAL-RRLKEDYPDKVLIASIMGEN-----EQ 114 L +++ +GF N + A+L RRL P + + +G++ EQ Sbjct: 117 RLPEQEALINRMGFNN----------QGAASLARRLARLQPAPIPVGVSIGKSKITPLEQ 166 Query: 115 QWEELARLVQE--AGADMIECNFSCPQMTSHAMGSDVGQSPELVE-------KYCRAVKR 165 ++ ++ A I N S P D Q L+ + R +R Sbjct: 167 AIDDYRASFRQLFPYAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQR 226 Query: 166 GSTLPMLAKMTPNIGDMC--EVALAAKRGGADGIAAINTVKS---ITNIDLNQKIGMPIV 220 G P+L K+ P++ D EV G GI A NT S +T +D P + Sbjct: 227 GPR-PLLVKIAPDLSDTAIEEVLTVCADHGVAGIIATNTTISREGLTGVD-------PRL 278 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTHPEL--RDFPISGIGGIETWEDAAEFLLLGAAT 278 ++ G SG+ P+ R + +R L PI G+GGI T +D L GA+ Sbjct: 279 AAEAG--GLSGR---PLIARALHVVRLIARLTGNRLPIIGVGGIHTPDDGLRMLEAGASL 333 Query: 279 LQVTTGIMQYG 289 +Q+ TG++ YG Sbjct: 334 IQIYTGLVYYG 344 >UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus RepID=C0WNB5_LACBU Length = 315 Score = 57.0 bits (136), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 99/221 (44%), Gaps = 11/221 (4%) Query: 101 DKVLIASIMGENEQQWEELARLVQEAGAD-MIECNFSCPQMTSHAMGSDVGQSPELVEKY 159 D +I SI G + Q E+ +Q++ D + E N SCP + S + E V Sbjct: 97 DNQVILSIAGLSVDQNLEMLHQIQDSLFDGLTELNLSCPNIKGE---SQIAYDFEAVRDI 153 Query: 160 CRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITN-IDLNQKIGMP 218 T + K+ P D+ + A IA +N++ SI N + +N + Sbjct: 154 LTKAFDFFTKDIGIKLPPYF-DLHQFDQIADVLNEFPIAYVNSINSIGNGLIVNPETESV 212 Query: 219 IVNGKSSISGYSGKAVKPIALRFIQ--QMRTHPELRDFPISGIGGIETWEDAAEFLLLGA 276 ++ K G G VKP AL ++ ++R PE+ I G GGI++ D E +L GA Sbjct: 213 VLKPKGGFGGLGGDYVKPTALANVRGLRLRLKPEI---AIIGTGGIKSGRDVFEHILCGA 269 Query: 277 ATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 +Q+ T +I + ++ L +A++G+ SL + G Sbjct: 270 NVVQIGTAFGFEDVKIFDRISKELKEIMAEKGYTSLDDFRG 310 >UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular organisms RepID=Q5PR57_DANRE Length = 407 Score = 56.6 bits (135), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 89/200 (44%), Gaps = 24/200 (12%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL------PMLAKMTPNIG- 180 AD + N S P D+ EL + VK +L P+L K+ P++ Sbjct: 204 ADYLVVNVSSPNTPGL---RDLQGKEELRHLLDKVVKERDSLRIENRPPVLVKIAPDLTT 260 Query: 181 -DMCEVALAAKRGGADGIAAINTVKSITNI--DLNQKIGMPIVNGKSSISGYSGKAVKPI 237 D ++A G DG+ NT S + D N + G SG+ +K + Sbjct: 261 QDKQDIAEVIMEVGVDGVMVSNTTVSRPDTLKDPN----------RVETGGLSGQPLKEL 310 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 + + +++M T + + PI G+GG+ + +DA + + GA+ +Q+ T ++ G +V + Sbjct: 311 STQTVREMYTLTQGK-LPIVGVGGVASGQDAMDKIRAGASLVQLYTALVYQGPPVVNKIK 369 Query: 298 SGLSHYLADQGFDSLQEMVG 317 L L QGF + E VG Sbjct: 370 RELDDLLKAQGFTCVAEAVG 389 >UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacteria RepID=D2Q7Y3_9BIFI Length = 375 Score = 56.6 bits (135), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/187 (29%), Positives = 83/187 (44%), Gaps = 13/187 (6%) Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPMLAKMT-- 176 ARLV E GA ++E N SCP + + + P LV + AVK P++ K+ Sbjct: 196 ARLVCETGAGLMEMNTSCPNEGHNRL---LCHDPHLVGRITEAVKNEIGDRPLVVKLAYI 252 Query: 177 PNIGDM-CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 PN D+ V A G G + INT+ S +D + +P SG G A++ Sbjct: 253 PNDADLEIMVKETAAHGTVQGFSTINTI-SAKLVDAHGNQALP--GAGRDRSGVCGNAIR 309 Query: 236 PIALRFIQQMRTHPEL--RDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 L + ++ E DF I G+GG+ ED + GA + TG M + + Sbjct: 310 GAGLDMVGRLHAIREKLGLDFTIVGVGGVVRPEDYRAYREAGANAVMSATGAM-WNANLA 368 Query: 294 EDMASGL 300 D+AS + Sbjct: 369 RDIASSI 375 >UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organisms RepID=Q7PYN9_ANOGA Length = 404 Score = 56.6 bits (135), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 106/240 (44%), Gaps = 23/240 (9%) Query: 92 LRRLKEDYP--DKVLIASIMGENEQQWEELARLVQEAG-----ADMIECNFSCPQMTS-H 143 LR +E P +V + +G+N+ + +A VQ AD + N S P Sbjct: 166 LRECREQQPPDQRVALGINLGKNKLSLDAIADYVQGVKRFGTLADYLVINVSSPNTPGLR 225 Query: 144 AMGSDVGQSPELVE--KYCRAVKRGSTLPMLAKMTPNIG--DMCEVA--LAAKRGGADGI 197 M S L E K ++ P+L K+ P++ D+ E+ + AK DG+ Sbjct: 226 TMQSKSTLQTLLTEVLKARASLPANEQRPILLKLAPDLSEEDLREIVDVVRAKACAVDGL 285 Query: 198 AAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPIS 257 ++N +++ + VN + G SG +K + I ++ E + PI Sbjct: 286 I-------VSNTTIDRPATLRSVNA-GQLGGLSGPPLKHRSTAMIARVYKLTEGK-IPII 336 Query: 258 GIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 G+GGI T EDA E + GA+ +Q+ T + +G +V + L L G+ S+Q+ VG Sbjct: 337 GVGGIFTGEDAFEKIEAGASAVQLYTSFIFHGPPVVPKIKRELDRLLEANGYASVQDAVG 396 >UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R4R9_9RHOB Length = 367 Score = 56.6 bits (135), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 92/215 (42%), Gaps = 43/215 (20%) Query: 128 ADMIECNFSCPQM-----------TSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 AD + N S P +H + + V E ++ R V P++ K+ Sbjct: 167 ADYLTANISSPNTPGLRDLQEKDALAHLLSAIVNARDEQEDRLGRKV------PVMLKIA 220 Query: 177 PNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQK--------IGMPIVNGKSSI 226 P++ + + E+A DG+ NT + + +Q+ G P+ + Sbjct: 221 PDVTEEALKEIAEVVMTNKVDGMIVSNTTIARPSTLKDQQQAEEAGGLSGAPLFERATIA 280 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 + +AV P D P+ G+GG++T E AA + GA +Q+ +G++ Sbjct: 281 LAKTRRAVGP----------------DLPLFGVGGVDTPEKAAAKIFAGANQIQLYSGMV 324 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 G +V+ + LS +A +G +LQE+VG+ N+ Sbjct: 325 YEGQTLVKKINKHLSRLVAARGVSNLQELVGIDND 359 >UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=Q1V0W4_PELUB Length = 350 Score = 55.8 bits (133), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 93/192 (48%), Gaps = 10/192 (5%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-AVKRGSTLPMLAKMTPNIGDMCEVA 186 AD I N S P + D + EL+ + VK S +P++ K++P+I D ++ Sbjct: 162 ADYITVNISSPNTENLRAFHDETKFDELLNAIEKEKVKLKSKIPIVVKISPDISD-EQIE 220 Query: 187 LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 L +K ++AI + S T +K+ + K G SGK ++ A + I + Sbjct: 221 LISKILIKHKVSAI--IVSNTTAKNREKLNNIL---KHQKGGLSGKPLEEEANKLISKF- 274 Query: 247 THPELR-DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 + L+ I G+GG+++ E A + GA+ +Q+ TG++ G IV + L L Sbjct: 275 -YKLLKGKIEIIGVGGVDSGESAYKKFQAGASYVQLYTGMVFQGPNIVGKIKKELKEILI 333 Query: 306 DQGFDSLQEMVG 317 D+G + +E++G Sbjct: 334 DEGIKNFKEIIG 345 >UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospirillum RepID=A3ETM0_9BACT Length = 368 Score = 55.8 bits (133), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 92/199 (46%), Gaps = 22/199 (11%) Query: 102 KVLIASIMGENE------QQWEELARLVQEAGADMIECNFSCPQMTSH--AMGSDVGQSP 153 +VL+ S++G Q + A L +E GA ++E NFSCP + + + S Sbjct: 153 QVLVLSLVGTQREERDLAQDFVYTAHLAKETGAKILEVNFSCPNVKGKEGQLYQNPDASG 212 Query: 154 ELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQ 213 E++++ + + R L M + N + + + A D I+AINTV T +N Sbjct: 213 EILKRIRKELGRDFHLIMKIGFSDN-PEHLDRLVEATSPYLDAISAINTV---TGTIINP 268 Query: 214 KIGMPIVNGK-SSISGYSGKAVKPIALRFIQQM-----RTHPELRDFPISGIGGIETWED 267 + G P + G SG G +K ++L+ I+ + R P+L + G+GG T ED Sbjct: 269 E-GKPALPGPGRERSGLCGSGIKNLSLKTIRGLKQALRRRAPQLS---LIGVGGFNTVED 324 Query: 268 AAEFLLLGAATLQVTTGIM 286 +F GA + TG M Sbjct: 325 YPDFREAGADIVMSATGAM 343 >UniRef50_A1B7Q9 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Paracoccus denitrificans PD1222 RepID=A1B7Q9_PARDP Length = 359 Score = 55.5 bits (132), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 59/242 (24%), Positives = 107/242 (44%), Gaps = 18/242 (7%) Query: 101 DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQ-SPELVEKY 159 D VL+AS++ + AR V++AG + E N P + A G+ + SP V + Sbjct: 113 DCVLVASVVMAGIEDAVRRARAVEDAGLRVFEFNIGTPYASQAAKGAVSTELSPARVAEL 172 Query: 160 CRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGAD-GIAAINTVKSITNIDLNQKIGMP 218 V ++P+ K++ + E+ AA GAD + A + + +++ Q P Sbjct: 173 VGQVTSAVSIPVWVKLSGQSERVPELVAAATGAGADSAVIAGRALGLVPDLETMQ----P 228 Query: 219 IVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAAT 278 ++ I GY P+ ++ R I GI G + D A +L GA+ Sbjct: 229 MLGTSCGIGGYWN---LPLTCHWLAMTRARLGAGRALI-GINGACSGRDVARMMLAGASA 284 Query: 279 LQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPR 338 + +++ +M G+ ++ D + L Y A +G S +++VG A D RS+ P Sbjct: 285 VGLSSAVMLRGWDVIRDAVADLDAYCAQKGA-SARDLVGR-------AADARRSFAEMPV 336 Query: 339 IN 340 ++ Sbjct: 337 LD 338 >UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L830_PLAKH Length = 556 Score = 55.5 bits (132), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/213 (23%), Positives = 93/213 (43%), Gaps = 27/213 (12%) Query: 111 ENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 + QQ E L R++ ++ + S+ +G DV + V R P Sbjct: 364 RDNQQSERLQRIILRVKEEVDKLE------ESNVVGDDVVRGDTWVNTSKRK-------P 410 Query: 171 ML-AKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 ++ K+ P++ G+ ++A + DG+ NT NI N + Sbjct: 411 LVFVKLAPDLEEGEKKKIADVLLKTKVDGMIICNTTTEKFNIK----------NFQDKKG 460 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ +K ++ +FI QM + + PI GGI T +DA E + GA+ Q+ + ++ Sbjct: 461 GVSGEKLKDVSTKFISQMYNYTN-KKIPIIASGGIFTGKDALEKIEAGASVCQLYSCLVF 519 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 G + + L H L +G+ L++ +G A+ Sbjct: 520 NGMKAAVRIKRELDHLLYQRGYYKLEDAIGKAH 552 >UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZTF1_OPITP Length = 332 Score = 55.1 bits (131), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 64/331 (19%), Positives = 137/331 (41%), Gaps = 47/331 (14%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 +L+ T+ G+ NP + +SP + E + + G +V +++ F+ Sbjct: 4 NLATTYLGLPLRNPLIVGASPFSDDLEAARQLQEAGAAALVMRSL-----------FEEQ 52 Query: 65 VKEDTGFIGFKNMEQIAEHPLEEN----------LAALRRLKE--------DYPDKVLIA 106 + + + +++E + E E + L R L++ D P +IA Sbjct: 53 IDLEQRALN-RDLEALTESFAEASSFFPEYGEYQLTPDRYLRQIELLTSELDIP---IIA 108 Query: 107 SIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG 166 S+ G + W + AR + AGAD IE NF G ++ EL+E R+V Sbjct: 109 SLNGRHPGGWLDYARKFEAAGADAIELNFYQLVTDPKVSGDEI--EDELIET-LRSVVTA 165 Query: 167 STLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 +P+ K++P + A ++ GA G+ N + + D++ P + + S Sbjct: 166 VRIPVAVKLSPFHTSLPHFTQALRQAGAAGLVLFNRLYQ-PDFDVDALEVQPTL--RLSD 222 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 G ++ +A+ + + ++ GG+ + D A+ +L GA +Q+ + ++ Sbjct: 223 PGELLLRLRWLAILSPNHLGS--------LAASGGVHSGTDVAKAVLAGADAVQIVSAVL 274 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + G +++ + ++ + + E G Sbjct: 275 RQGPAVLKTLLQDFETWMRTHEYTHVGEFRG 305 >UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=C0Z506_BREBN Length = 363 Score = 54.7 bits (130), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 50/180 (27%), Positives = 83/180 (46%), Gaps = 22/180 (12%) Query: 151 QSPELVEKYCRAVKRGST---------LPMLAKMTPNIGD--MCEVALAAKRGGADGIAA 199 Q E + RAVK +T P+L K+ P++ D M +V AA G GI A Sbjct: 190 QETESLRHLVRAVKEKATEMEGRSIKKKPILLKVAPDMSDEHMRDVVHAAVEEGISGIIA 249 Query: 200 INTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRD-FPISG 258 NT S + ++ G SG+ + + +++++ + E+ D PI G Sbjct: 250 TNTTLSREAVSGHR--------FAEEAGGLSGRPLTERSTAWVKEI--YQEVGDKVPIIG 299 Query: 259 IGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 +GGI EDA + GA+ +QV TG++ G I + + L + GF + E++G+ Sbjct: 300 VGGIYNGEDAYAKIRAGASLVQVYTGMIYQGPGIAKQINKKLLKLMQRDGFKHISEVIGV 359 >UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria RepID=PYRD_THEFY Length = 377 Score = 54.3 bits (129), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 59/199 (29%), Positives = 87/199 (43%), Gaps = 18/199 (9%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG------STLPMLAKMTPNIGD 181 AD + N S P G Q+ E + AV+R LP+L K+ P++ D Sbjct: 176 ADYLVVNVSSPNTP----GLRDLQATERLRPLLSAVRRTLDEAGRPDLPLLVKIAPDLAD 231 Query: 182 --MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 + VA A G DGI A NT S + + P G SG +K AL Sbjct: 232 EDIDAVADLAVELGLDGIIATNTTVSRDGLATD-----PEEVAALGAGGLSGAPLKERAL 286 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + ++++R R I+ +GGIET EDA + GA +Q TG++ G + G Sbjct: 287 QVLRRLRARVGDRLVLIA-VGGIETPEDAWARIRAGATLVQGYTGLIYGGPLWPRRIHRG 345 Query: 300 LSHYLADQGFDSLQEMVGL 318 ++ GF S+ E VG+ Sbjct: 346 VAALARRDGFASIAEAVGV 364 >UniRef50_A7H8H3 Dihydroorotate dehydrogenase n=4 Tax=Anaeromyxobacter RepID=A7H8H3_ANADF Length = 328 Score = 54.3 bits (129), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 69/320 (21%), Positives = 136/320 (42%), Gaps = 28/320 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF------IANEVS 58 +L + G+ P+P L+S + N E A G G VV +++ F A+ + Sbjct: 3 ELVTEYMGLALPSPLVLASCALSNRVENLEMAEGHGAGAVVLRSL--FEEQLEGAASALE 60 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + + +++ H + L+ + R K V IAS+ W + Sbjct: 61 EELLRGAESNPEARTYFPPQRVGPH---DYLSLVERAKRALEIPV-IASLNCAAPGSWTD 116 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDV-GQSPELVEKYCRAVKRGSTLPMLAKMTP 177 AR +++AGAD +E N + G++V + E+V AV++ +P+ K++P Sbjct: 117 YARDIEQAGADALEVNLYSVEADPTVSGAEVEARYLEVVA----AVRQAVRIPIAVKLSP 172 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + A G +G+ N +I L + +P + + +A+ P Sbjct: 173 FFSSLAHFATRLDGLGVNGLVLFNRFLQ-PDISLERMAALPTMTPSA-----PSEALVP- 225 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 LR+I + H +R ++ G+ + +L GA +Q+ + +M+ G + + Sbjct: 226 -LRWIALL--HGRVRAH-LAASTGVYDAPGVLKQVLAGAQVVQLASTLMKNGIPHLGKVL 281 Query: 298 SGLSHYLADQGFDSLQEMVG 317 +G+ +L +G SL E+ G Sbjct: 282 AGIEDWLDRRGVSSLDELRG 301 >UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter pasteurianus RepID=C7JI08_ACEP3 Length = 336 Score = 54.3 bits (129), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 77/339 (22%), Positives = 133/339 (39%), Gaps = 26/339 (7%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + D+ + G++ +P S+SP+ E + D G +V ++ F + + Sbjct: 1 MAMDMRTNYLGLELAHPVVASASPLTADLEGILRVADAGASAIVMASV--FEEDIQAQEL 58 Query: 62 DHLVKEDTG------FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 +TG G+ + A PL+ LA LR E + IAS+ G Sbjct: 59 AEAALWETGENSHPEAAGYFPVMHHAS-PLDGRLAVLRSAAERAGVPI-IASLNGCTPAG 116 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 W A+ +++AGA IE NF G+ V E + R V+ +P+ K+ Sbjct: 117 WLRFAKDMEQAGAAAIELNFWHVPTNPDETGAQV---EERCIQVLRDVRAQVKVPVSVKL 173 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 +P + GA GI N+ L + + V S Y + Sbjct: 174 SPFFSSPGNMVKRLSENGAGGIVLFNSFYEPGLRSLTESAEVDFVPS----SAYELR--- 226 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 + L + + H + D IS GG+ + D A+ LL GA V + ++Q G + Sbjct: 227 -LPLMWAALLSEHCQ-ADLAIS--GGVHSGMDVAKCLLAGADVAMVASVLLQKGPNYIST 282 Query: 296 MASGLSHYLADQGFDSLQEMVG--LANNNIVPAEDLDRS 332 + + L +++ Q +++E G A AED R+ Sbjct: 283 LLNELREWMSMQNLGAVKEFKGRMAARGTAAQAEDFLRT 321 >UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanobacteria RepID=A8ZNQ0_ACAM1 Length = 339 Score = 53.9 bits (128), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 69/334 (20%), Positives = 143/334 (42%), Gaps = 52/334 (15%) Query: 5 DLSITFCGVKFPNPFCLSS-SPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS T+ G + +P + + +P+ + D G +V ++ F+ Sbjct: 2 DLSTTYLGTRLRSPLVVGACAPLSEKIDHLRHMEDAGAAAIVLHSL-----------FEE 50 Query: 64 LVKEDTGFIGFKN-----MEQIAEH-------------PLEENLAALRRLKEDYPDKVLI 105 +++D +GF + E AE P E+ L + + K D +I Sbjct: 51 QLRQDR--LGFHHHLTHGTESFAEALSYCPEPDVFHVGP-EQYLEHIHQAKA-IVDTPII 106 Query: 106 ASIMGENEQQWEELARLVQEAGADMIECN-FSCPQMTSHAMGSDVGQSPELVEKYCRAVK 164 AS+ G W A+ ++EAGAD +E N ++ P + A G+++ QS V Sbjct: 107 ASLNGATIGGWTNYAKKIEEAGADALELNIYTVPTEMAIA-GAEIEQS---YIDIVHTVT 162 Query: 165 RGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 +P+ K++P ++ +A G +G+ N +ID+ + + Sbjct: 163 STVNIPVAIKLSPFFSNLAYMAKRLTDAGVNGLVLFNRFYQ-PDIDIET------LEVRP 215 Query: 225 SISGYSGKAVKPIALRFIQQMR-THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 ++ + + ++ + LR+I + T P DF + GI T D + +++GA + + Sbjct: 216 NLLLSTPQDIR-LPLRWIAILYGTLP--VDF--AATSGIHTAADVLKMMMVGANATMLVS 270 Query: 284 GIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 ++++G + + L +L + ++S+Q++ G Sbjct: 271 VLIRHGIDHLRTLEHALCQWLKEHEYESIQQLQG 304 >UniRef50_Q8TY44 Ferredoxin n=1 Tax=Methanopyrus kandleri RepID=Q8TY44_METKA Length = 192 Score = 53.9 bits (128), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 30/77 (38%), Positives = 43/77 (55%), Gaps = 6/77 (7%) Query: 336 YPRINLDKCVGCGRCYISC----YDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVG 391 +P ++LD+C+ CG C +C DG AME SE+ H E+C+ C LC VCP G Sbjct: 37 FPDVDLDRCILCGACADACPVEGRDGCPPAMEMSEEGPVLH--KERCIRCGLCVEVCPTG 94 Query: 392 CIELGEVKFKKGEKEHP 408 IE+G + + E+ P Sbjct: 95 AIEMGTLHEEVEERVQP 111 >UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota RepID=Q75XR0_EUGGR Length = 435 Score = 53.5 bits (127), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 90/351 (25%), Positives = 142/351 (40%), Gaps = 66/351 (18%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYD----TGWGGVVFKTIGFFI-ANEVSP 59 DL + G+KF NP L++ ++ +A D TG+G V T+ SP Sbjct: 97 DLEMEVWGLKFSNPLGLAAG-----FDKHGEAVDALLGTGFGFVEIGTVTPLPQPGNPSP 151 Query: 60 RFDHLVKEDTGFI---GFKNMEQIAEHPLEENLAALR-----RLKEDYPDKVLIASIMGE 111 R L ++D I GF + + LAA+R R P L+ +G+ Sbjct: 152 RMFRL-EQDRAIINRYGFNS----------QGLAAVRKRLEARQHRPAPRGGLVGVNVGK 200 Query: 112 NEQQWEELA---RLVQEAG--ADMIECNFSCPQ-------MTSHAMGSDVGQS----PEL 155 N+ Q + A + ++E G AD + N S P AM + S E+ Sbjct: 201 NKLQEDAAADYSKGLRELGPYADYLVINVSSPNTPGLRNLQKRSAMADLIKASMVARDEV 260 Query: 156 VE----KYCRAVKRGSTLPMLAKMTPNIG-----DMCEVALAAKRGGADGIAAINTVKSI 206 V + A K + LP+L K+ P++ D+ EV + K DG+ NT S Sbjct: 261 VRDADGRRAAAGKSAAPLPLLIKIAPDLTAEEKQDIAEVVMETK---IDGLIVSNTTVSR 317 Query: 207 TNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWE 266 L+ K G SG ++ ++ + I+ M PI G+GG+ T E Sbjct: 318 PASLLSPH--------KGQTGGLSGAPLREMSTQAIRDMYALTR-GTVPIVGVGGVATGE 368 Query: 267 DAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 D E L GA+ +Q+ + ++ G + GL L + F S + VG Sbjct: 369 DVLEKLKAGASLVQMYSMLVYDGPGAPPRVKKGLLQALRREHFGSARSAVG 419 >UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NV76_9GAMM Length = 367 Score = 53.5 bits (127), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 87/203 (42%), Gaps = 18/203 (8%) Query: 122 LVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAKMTPN 178 L+Q+ G AD I N S P D L+++ A ++ P+L K+ P+ Sbjct: 165 LIQQLGPFADYISINVSSPNTPELRRLQDPQSLRPLLQELREARQKLQRQPPLLLKIAPD 224 Query: 179 IGDMCEVALAA----KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 + ALAA + DG A NT L + P + G SG + Sbjct: 225 LAPDEVTALAALAQEPQPLLDGFIATNTT-------LGRPSDWP---HPAEAGGLSGAPL 274 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 K A I Q+ R PI G+GG+ T +D + + GA+ +Q+ T ++ G +V+ Sbjct: 275 KRRANGIIAQLYRASSGR-LPIIGVGGVATAQDVLDKIEAGASLVQLYTALIYEGPDLVQ 333 Query: 295 DMASGLSHYLADQGFDSLQEMVG 317 + L L D+G D L +VG Sbjct: 334 QITDALPELLTDRGVDHLGALVG 356 >UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_LACBS Length = 499 Score = 53.1 bits (126), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/148 (30%), Positives = 69/148 (46%), Gaps = 27/148 (18%) Query: 171 MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTV----KSITNIDLNQKIGMPIVNGKS 224 ++ K P++ ++ ++A + DG+ NT KS+ N + KS Sbjct: 292 LVLKFAPDLNESELADIADVIRNSSIDGVIVSNTTVQRPKSLVNPN------------KS 339 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 + G SG VKP++L+ ++ +R H P+ G GGI T DA EF GA+ +QV TG Sbjct: 340 EMGGLSGPPVKPLSLKALRILRGHLPA-SIPLIGCGGISTGADALEFAKAGASMVQVYTG 398 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSL 312 +GY V G + DQ D L Sbjct: 399 ---FGYDGV-----GACRRIKDQVVDEL 418 >UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular organisms RepID=PYRD_SYNPX Length = 396 Score = 53.1 bits (126), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 89/342 (26%), Positives = 144/342 (42%), Gaps = 52/342 (15%) Query: 4 KDLSI--TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDT-GWGGVVFKTIGFF-IANEVSP 59 +DL + G +FPNP L++ N + A +D G+G T+ + P Sbjct: 65 RDLRLEQVLFGCRFPNPVGLAAGFDKNG--VAAGLWDRFGFGFAEVGTVTWHGQPGNPRP 122 Query: 60 RFDHLVKEDTGF--IGFKNMEQIAEHPLEENLAALRRLKEDY----PDKVLIASIMGEN- 112 R L +E +GF N + ALRR E P + +++G N Sbjct: 123 RLFRLAQEQAALNRMGFNN----------DGAQALRRTLERQRLAPPGRR--PAVLGINV 170 Query: 113 --------EQQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 EQ E+ A ++ AD N S P D+ S +L R Sbjct: 171 GKSKVTALEQAPEDYASSLELLAPLADYAVINVSSPNTPGL---RDLQDSSQLRRLVERL 227 Query: 163 VKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 + + P+L K+ P++ D + +A A G G+ A+NT S+ + L Q+ + Sbjct: 228 RRLPACPPLLVKIAPDLEDEAIDGIARLAFEEGLAGVIAVNT--SLDRLGLEQR--RLLQ 283 Query: 221 NGKS---SISGYSGKAVKPIALRFIQQMRTH--PELRDFPISGIGGIETWEDAAEFLLLG 275 G++ G SG ++ AL I+++R P L + G+GGI++ E A E + G Sbjct: 284 TGRTLAEEAGGLSGAPLRQRALEVIRRLRASAGPALT---LIGVGGIDSAEIAWERITAG 340 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 A+ +Q+ TG + G +V + GL L G S+ E VG Sbjct: 341 ASLIQLYTGWIFQGPELVPRILEGLQLQLDRHGLRSIAEAVG 382 >UniRef50_B3DVT8 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DVT8_METI4 Length = 314 Score = 53.1 bits (126), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 101/222 (45%), Gaps = 30/222 (13%) Query: 104 LIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVE----KY 159 +IAS+ G + W A+ ++EAGAD IE N + D+ Q + +E + Sbjct: 82 IIASLNGRSPGWWCRYAKQIEEAGADGIELNI-------YPFPLDINQPSDSIEMDTLEI 134 Query: 160 CRAVKRGSTLPMLAKMTP---NIGDMCEVALAAKRGGADGIAAINTVKSITNIDL-NQKI 215 R V++ +P+ K+ P N+G+M + AA G +G+A N +ID+ N +I Sbjct: 135 VRLVRKEIQIPLGVKIYPYYTNVGNMAQRFQAA---GVNGLALFNRFLQ-PDIDVENFEI 190 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 I G S + +AL +I + +L ++ GG+ DA +L G Sbjct: 191 KRGIQLGTSRDNR--------LALSWIAFLYNRLKL---DLAATGGVMEAVDAIRLILAG 239 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 A+ + V + I++ G + M + ++ F SL++ G Sbjct: 240 ASVVMVCSAILEKGIGYIPVMEKEIVEWMERHRFSSLEDWRG 281 >UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobacteraceae RepID=D1B1W1_SULD5 Length = 355 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 27/235 (11%) Query: 93 RRLKEDYPDKVLIASIMGENE--------QQWEELARLVQEAGADMIECNFSCPQMTSHA 144 +RL+ YP +A+ +G+N+ + +E+L + ++ +D + N S P Sbjct: 134 KRLESLYPFATPLAANIGKNKITSAENALKDYEKLIKRFKDV-SDFLVVNISSPNTP--- 189 Query: 145 MGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN--IGDMCEVALAAKRGGADGIAAINT 202 G Q+ +++ K + P+L K+ P+ I + E+ A GA GI A NT Sbjct: 190 -GLRDLQNEAFIKELFMMAKELTCKPVLLKIAPDLEIKEAIELCSCALENGAKGIVATNT 248 Query: 203 VKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGI 262 I ++ G SGK + + R + + + IS +GGI Sbjct: 249 T-----------IDYSLLPNAKDFGGISGKVLCEKSFRMFEGIAKEFFGKTTLIS-VGGI 296 Query: 263 ETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 ++ E+A L GA+ LQ+ + + G + + G+ + GF + E++G Sbjct: 297 DSAEEAYRRLKAGASLLQIYSAFIFKGPSLNRTINLGILERMERDGFHHISEVIG 351 >UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 Tax=Dekkera bruxellensis RepID=A2VBP6_DEKBR Length = 442 Score = 52.4 bits (124), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/203 (25%), Positives = 94/203 (46%), Gaps = 23/203 (11%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV----KRGSTL-------PMLAKMT 176 AD + N SCP S D+ + L+E + K G+ + P++ K+ Sbjct: 244 ADALVLNVSCP---SAPGVRDLQEKDVLLELLTKVREERDKVGANVIDPARKPPIIVKVA 300 Query: 177 PNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ + + ++A AK+ DGI NT + + + P+V K G SG+A+ Sbjct: 301 PDLSEKEIADIADVAKKSKIDGILMSNTTTARPASLITKG---PVVQEKG---GLSGRAM 354 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + I+L+ + +R + + D + G GGI T +DA F GA+ +++ T G I + Sbjct: 355 RDISLKAFRTLRKYTKDSDLVLIGCGGIFTGKDAIAFAKAGASAIELYTSFAYRGPGIPD 414 Query: 295 DMASGLSHYLADQGFDSLQEMVG 317 + + L +G + E+VG Sbjct: 415 KIKDEIVQELKKEG-KTWMEIVG 436 >UniRef50_C1ZGV0 tRNA-dihydrouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZGV0_PLALI Length = 322 Score = 52.0 bits (123), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 43/191 (22%), Positives = 76/191 (39%), Gaps = 30/191 (15%) Query: 86 EENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSH 143 E + A++ L ++ + I G + Q E AR+++E G M++ NF CP ++ Sbjct: 49 ERDKRAIKLLSTTSAERPAVGQISGNDAAQIGEAARVIEELGFSMVDLNFECPIRRLVGR 108 Query: 144 AMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT--PNIGDMCEVALAAKRGGADGIAAIN 201 G + P+ + + A K+ ++P+ K+ P G+ V A + A G A I Sbjct: 109 GEGGALMGQPQRIAELVAAAKQAVSIPVTVKLRTGPKAGEDTAVETAQRVEQAGGAAIIL 168 Query: 202 TVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGG 261 +S+ L + K ++S P+ G GG Sbjct: 169 HARSVEQAYLGGPDWQHVTRVKEAVS--------------------------IPVLGSGG 202 Query: 262 IETWEDAAEFL 272 + T +DA FL Sbjct: 203 VRTPQDAISFL 213 >UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria RepID=PYRD_VEREI Length = 360 Score = 52.0 bits (123), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 51/186 (27%), Positives = 82/186 (44%), Gaps = 28/186 (15%) Query: 128 ADMIECNFSCPQMTS-------HAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 AD + N S P + A+ +G E + A + G +P+ K+ P++ Sbjct: 174 ADYVALNISSPNTQNLRTLQGDAALDHLLGAIAE--RRATLAARHGRRVPVFVKIAPDL- 230 Query: 181 DMCEVALAA---KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS---GYSGKAV 234 D +++L A +R G DG+ A NT I +V G+ G SG V Sbjct: 231 DEAQLSLMAATLQRHGIDGVIATNTT-----------IDRAVVQGQRHAQESGGLSGAPV 279 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + + I Q+R + FPI G+GGI + EDA + GA +Q+ TG++ G +V Sbjct: 280 LQASNQVIGQLRAALG-KGFPIIGVGGIMSAEDAVSKIRAGADLVQIYTGLIYEGPALVV 338 Query: 295 DMASGL 300 A + Sbjct: 339 QAARAI 344 >UniRef50_A8L1Y0 Dihydroorotate oxidase n=4 Tax=Frankia RepID=A8L1Y0_FRASN Length = 321 Score = 51.6 bits (122), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 47/181 (25%), Positives = 82/181 (45%), Gaps = 27/181 (14%) Query: 87 ENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMG 146 E L A+ + Y K L+ S+ G +++ LAR+ + GAD+IE N CP + Sbjct: 80 EQLPAMADIAHGY-GKPLVVSVAGFAAEEYATLARVAADTGADLIELNLGCPNVWDGGSQ 138 Query: 147 S-----DVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG-----------DMCEVALAAK 190 D+GQ+ + + A+ G P + P G AL + Sbjct: 139 KRIACFDLGQTDAICAQVEAALAGGRAGPG-HRRAPAYGVKVSPFSDPEALADLAALLGR 197 Query: 191 RGGADG----IAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 R ADG + A+NT + +D ++ P+++ +++G SG A+KP+ L ++Q+R Sbjct: 198 RSEADGGPRFVTAVNTFPNALVLDDRRR---PVLD--VALAGLSGAALKPVGLGQVRQLR 252 Query: 247 T 247 Sbjct: 253 A 253 >UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococcus RepID=Q5HL43_STAEQ Length = 354 Score = 51.6 bits (122), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 99/214 (46%), Gaps = 22/214 (10%) Query: 113 EQQWEELARLVQEAGADM--IECNFSCPQMTSHAMGSDVGQSPELVEKYCR-AVKRGSTL 169 E ++++ +++ D+ N S P + D + L + K + Sbjct: 153 ENRYQDYIKVIDTFKNDVSFFTVNISSPNTENLQNFHDEDEFSMLCDALNSFKAKNNINV 212 Query: 170 PMLAKMTPNIG-DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS- 227 P+ K+T ++ D + L + DG+ NT + Q+ G+ N K+ I Sbjct: 213 PIFLKLTSDMELDGFKKILPSITDTFDGVMLANTTR--------QRDGL---NSKNKIQE 261 Query: 228 -GYSGKAVKPIALRFIQQMR-THPELR-DFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG+ P+ R +Q ++ + + R +F I G GGI + EDA + L GA+ LQ+ + Sbjct: 262 GGLSGR---PLFQRNLQLVKYAYQQTRGNFLIIGTGGIFSSEDAIKMLRNGASLLQIYSS 318 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 ++ G + + M ++HYL G+ ++ +++GL Sbjct: 319 LVIEGPGLTKKMNKEIAHYLTRHGYANVSDIIGL 352 >UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Schizosaccharomyces RepID=PYRD_SCHPO Length = 443 Score = 51.2 bits (121), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 37/122 (30%), Positives = 61/122 (50%), Gaps = 18/122 (14%) Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTV----KSITNIDLNQKIGMPIVNGK 223 P+L K+ P++ + + ++A K+ DG+ NT K++ + ++ G Sbjct: 302 PVLVKIAPDLNEEELTDIADVLKKCKIDGVIVGNTTVQRPKTLKSTSHVEETG------- 354 Query: 224 SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 G SG +KPIAL ++ +R H D PI G GGI + +DA E+ GA +QV T Sbjct: 355 ----GLSGPPLKPIALNTLRTLRKHLS-SDIPIIGCGGISSGKDAIEYARAGATMVQVYT 409 Query: 284 GI 285 + Sbjct: 410 AL 411 >UniRef50_D2RDC3 Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit n=1 Tax=Archaeoglobus profundus DSM 5631 RepID=D2RDC3_ARCPR Length = 91 Score = 51.2 bits (121), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 24/61 (39%), Positives = 34/61 (55%) Query: 337 PRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 P++N DKCVGCG C + C DG + + EK + + C GC +C +CP IE+ Sbjct: 27 PKVNPDKCVGCGECRMLCPDGCIELVHVEEKKVVAKVDYDYCKGCGICSDICPANAIEMV 86 Query: 397 E 397 E Sbjct: 87 E 87 >UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmida RepID=A7AUQ8_BABBO Length = 415 Score = 50.8 bits (120), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 39/152 (25%), Positives = 74/152 (48%), Gaps = 14/152 (9%) Query: 171 MLAKMTPNIG-----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 +L K++P++ D+ +++L DGI A NT + N+ + + + Sbjct: 248 LLIKISPDVSRQELEDIADISLTHH---VDGIIATNTTITRDNV-----VPSDLKTAGNP 299 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SG+ +K ++ + + + E + PI GGI T +DA E + GA+ Q+ T + Sbjct: 300 KGGLSGRPLKTMSKKIVYDLYELTEGK-IPIIACGGISTAQDALEMIEAGASLCQIYTAL 358 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + G I M +GL+ L +G+ ++ E +G Sbjct: 359 VYEGPGIPSRMKNGLADLLMKKGYLNVSEAIG 390 >UniRef50_A6UTY7 4Fe-4S ferredoxin iron-sulfur binding domain protein n=1 Tax=Methanococcus aeolicus Nankai-3 RepID=A6UTY7_META3 Length = 418 Score = 50.4 bits (119), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/71 (40%), Positives = 38/71 (53%), Gaps = 6/71 (8%) Query: 330 DRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCP 389 D+ YIV N D C+GC CY C G + S +TR P+ N + CV C LC + CP Sbjct: 305 DKCYIV----NEDACIGCRICYKVC--GVDDTINISSETRMPYINPKLCVRCGLCYNECP 358 Query: 390 VGCIELGEVKF 400 V I+L + K Sbjct: 359 VNAIDLTDTKI 369 >UniRef50_B0TDY0 Iron-sulfur cluster-binding protein n=1 Tax=Heliobacterium modesticaldum Ice1 RepID=B0TDY0_HELMI Length = 374 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 8/89 (8%) Query: 316 VGLANNNIVP--AEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHC 373 V N++ P A + RS P + DKC+GC C SC + R P Sbjct: 285 VNFVENHLPPFLARPISRSLRPLPAFDRDKCIGCRICLQSC------PADALRMERIPQL 338 Query: 374 NTEKCVGCLLCGHVCPVGCIELGEVKFKK 402 + +KC+GCL C +CP +E+ + + Sbjct: 339 DKDKCIGCLCCQEMCPERAVEVRQTGLSR 367 >UniRef50_A6L8J9 Putative uncharacterized protein n=6 Tax=Bacteroidales RepID=A6L8J9_PARD8 Length = 258 Score = 50.1 bits (118), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/96 (33%), Positives = 39/96 (40%), Gaps = 26/96 (27%) Query: 329 LDRSYIVYPRIN-----------LDKCVGCGRCYISCYDG-----GHQAMEWSEKTRTPH 372 L +SY+VYP D C+ CG C C G G EW++ Sbjct: 170 LLKSYMVYPLFTHFAIGSNRFYATDTCISCGICAKVCPTGTISLSGDGKPEWADT----- 224 Query: 373 CNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHP 408 CV C+ C H CPV IE G + KKG HP Sbjct: 225 -----CVQCVACIHRCPVRAIEYGTISLKKGRYHHP 255 >UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=PYRD_DICDI Length = 370 Score = 49.7 bits (117), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 14/185 (7%) Query: 114 QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELV-EKYCRAVKRGST--LP 170 Q + + R+ +AGA M+E N+SCP + + + +P+ V E VK S+ +P Sbjct: 180 QDFVDTVRIACDAGAKMVEVNYSCPNVVTGE--GQIYHNPDAVYEISSTLVKELSSKNIP 237 Query: 171 MLAK--MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI-GMPIVNGKSSIS 227 ++ K + ++ M + A+R G IA INT+ ++ + KI G P + S Sbjct: 238 LIIKVGVMDDLEKMERLFQQAERAGVAAIAGINTL----SMKVTDKITGEPSLGASRLTS 293 Query: 228 GYSGKAVKPIALRFIQQMRT--HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G G ++ AL ++ + + + G GGI E +FL GA TG+ Sbjct: 294 GVCGAPIRSAALDWVSTASSIIKKQNSKLKLLGCGGIVKPEHFDDFLNSGADIAMSATGL 353 Query: 286 MQYGY 290 M Y Sbjct: 354 MWDPY 358 >UniRef50_C0CVL1 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVL1_9CLOT Length = 291 Score = 48.9 bits (115), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 55/212 (25%), Positives = 88/212 (41%), Gaps = 22/212 (10%) Query: 117 EELARLVQEAGADM-------IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL 169 E+L LV+ AG IE N +CP + + + + R V+ + Sbjct: 86 EDLEGLVRLAGTAAGCREVAGIEINMNCPYSMAATDPRQYWRDYGWLREMIRGVREAAGE 145 Query: 170 PMLAKMTPN-IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L P + D+ ++A K GADG + + ID+ + G S G Sbjct: 146 KLLIIKVPTTMVDVEDIAAIVKECGADGFTSFGALTGCA-IDVRTR---EFRCGNSGSGG 201 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM-- 286 Y G +KP+AL R H + D PI GG+ +D E ++ GA +QV + + Sbjct: 202 YCGPGLKPLALWSCS--RVHKAV-DIPIFSAGGVTNADDVIEHIMAGAWMVQVGSANLTR 258 Query: 287 -QYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + R++E L L + G SL E+ G Sbjct: 259 PDFMPRLIES----LDRRLDELGIRSLDEIRG 286 >UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UZD6_NAEGR Length = 369 Score = 48.9 bits (115), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 48/195 (24%), Positives = 84/195 (43%), Gaps = 13/195 (6%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG-----DM 182 AD + N S P + L+E+ +K+ +P+L K+ P++ D+ Sbjct: 173 ADFLVINVSSPNTQHLRSLQEKSSLDTLIEEVSTELKKHKNIPLLIKIAPDLTLDQQRDI 232 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 +AL GG I NT + Q +P NG S G SG+ + + + + Sbjct: 233 ASLALKHSIGG---IIVSNTTIERPFVSSEQINAIP--NG--SAGGMSGRPLFNQSTKVL 285 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + M E + + G+GG+ DA + + GA+ +QV T G +V + L+ Sbjct: 286 KNMYKLTEGK-VTLIGVGGVWDGYDALQKIQAGASLVQVYTAFTAQGPAVVGKIKRELAQ 344 Query: 303 YLADQGFDSLQEMVG 317 LA+ G+ + + VG Sbjct: 345 LLAEGGYARVSDAVG 359 >UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whipplei RepID=Q83GM4_TROWT Length = 335 Score = 48.9 bits (115), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 69/299 (23%), Positives = 116/299 (38%), Gaps = 35/299 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L T G+ F P +++ ++ Y G+G V T+ PR H Sbjct: 41 LGTTSMGLYFDTPLGIAAG-FDKFADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRI-HR 98 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG--------ENEQQW 116 V I + EN+ +R+ P +I +G E+ + + Sbjct: 99 VMSQKALINSMGFNNPGAQKMRENILKVRKSGRRLP---IIGVNIGKSKVCPLEESAKDY 155 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS---TLPMLA 173 + L+ + +D + N S P VG + K R+VK + P+L Sbjct: 156 VKSFELLADV-SDYLVINVSSPNTEGLRTLQSVGN----LNKILRSVKPIADRFKRPVLI 210 Query: 174 KMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI-SGYS 230 K++P++ D+ +AL K G G+ A NT ++ G+P N SS+ G S Sbjct: 211 KISPDLSNSDVTNIALLVKEFGLAGVVASNTT--------TKRTGLP--NEFSSLHGGLS 260 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 G +K +L ++ +R F I +GG+ + D E L GA +Q T + G Sbjct: 261 GPMLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNG 319 >UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobacillales RepID=A0NIQ6_OENOE Length = 329 Score = 48.9 bits (115), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 45/216 (20%), Positives = 94/216 (43%), Gaps = 13/216 (6%) Query: 107 SIMGENEQQWEELARLVQEAG-ADMIECNFSCPQMTSH-AMGSDVGQSPELVEKYCRAVK 164 SI+G ++ + + + +Q +G + + E N SCP + + D + E+++ Sbjct: 116 SIVGLSQSEIIDNLKKLQASGFSGLTELNLSCPNVPGKPQIAYDFTATREILDNVFAFYS 175 Query: 165 RGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITN-IDLNQKIGMPIVNGK 223 + P+ K+ P D A + +N + S+ N + ++ + P++ K Sbjct: 176 K----PLGVKLPPYF-DTAHFDQIASILNDYPLTYVNAINSVGNGLVIDPETDTPVIKPK 230 Query: 224 SSISGYSGKAVKPIALRFIQQMRT--HPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 G GK +K AL ++ +R +P+++ I GG+ D + LL GA + + Sbjct: 231 DGFGGLGGKQIKATALANVRALRQRLYPQIK---IIATGGVTNGRDVYDHLLCGADLISI 287 Query: 282 TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + + G + + L AD+G L+++ G Sbjct: 288 GSQLEIEGPTVFARLEKELEEIFADKGITDLRQVRG 323 >UniRef50_B3P4V6 GG16516 n=3 Tax=cellular organisms RepID=B3P4V6_DROER Length = 139 Score = 48.5 bits (114), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/138 (28%), Positives = 67/138 (48%), Gaps = 13/138 (9%) Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 K+ DG+ NT S NI N K+ G SG +K + I QM Sbjct: 11 KKSSVDGLIVSNTTVSRENIG-NNKLA-------EETGGLSGPPLKARSTEMIAQMY--- 59 Query: 250 ELRD--FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 +L D PI G+GG+ + DA E + GA+ +Q+ T ++ G +V+D+ + LS + Sbjct: 60 QLTDGKIPIIGVGGVASGYDAYEKIEAGASYIQIYTSLVYEGPALVDDIKAELSALITRL 119 Query: 308 GFDSLQEMVGLANNNIVP 325 G +++ ++VG + +P Sbjct: 120 GHNNVADVVGTNSKFYLP 137 >UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria RepID=PYRD_ROSCS Length = 367 Score = 48.1 bits (113), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 23/199 (11%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP--MLAKMTPN--IGDMC 183 AD + N S P + EL+ + R + G P + K++P+ + + Sbjct: 172 ADYVAVNISSPNTPGLRRLHERAALEELLRELMR-LNHGLLYPRPIALKISPDETLDQIE 230 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 EV A G A NT ++ L ++ + G SG+ + P A + I+ Sbjct: 231 EVVRAGCEAGVAAFIATNT--TLAREGLRSRLA-------NETGGLSGRPLAPRARQVIR 281 Query: 244 QM----RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + R P P+ G+GG+ T +DA + GA +Q+ TG++ G I ++ G Sbjct: 282 AIYRLTRGTP-----PVIGVGGVLTADDAYAHIRAGARLVQLYTGMVYAGPAIAREIKRG 336 Query: 300 LSHYLADQGFDSLQEMVGL 318 L+ L GF S+ + G+ Sbjct: 337 LAQLLRRDGFVSVTQATGV 355 >UniRef50_Q2LR94 TRNA-dihydrouridine synthase n=2 Tax=Deltaproteobacteria RepID=Q2LR94_SYNAS Length = 326 Score = 48.1 bits (113), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 40/174 (22%), Positives = 81/174 (46%), Gaps = 26/174 (14%) Query: 101 DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEK 158 DK L I G + + R+V + GAD+I+ N CP ++ + G+ + + P LV + Sbjct: 65 DKPLGVQIFGNDPTTMADAVRIVDDYGADLIDLNMGCPVKKVVKNGAGAALLKDPGLVSQ 124 Query: 159 YCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMP 218 +V++ + P+ K+ R G + + +IN V+ I I Q I Sbjct: 125 ILESVRKATRKPLTVKI---------------RSGWN-LQSINAVQ-IARIAEQQGIDAV 167 Query: 219 IVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL 272 V+ ++++ G++G A R I++++ ++ + G G +++ DA + Sbjct: 168 FVHARTAVQGFAGSA----DWRIIEEIKNSVGIK---VIGNGDVKSGADAWRMI 214 >UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Plasmodium vivax RepID=A5K1N1_PLAVI Length = 572 Score = 47.8 bits (112), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 39/128 (30%), Positives = 61/128 (47%), Gaps = 12/128 (9%) Query: 204 KSITNIDLNQKI-GMPIVNGKS----------SISGYSGKAVKPIALRFIQQMRTHPELR 252 KSI N+ LN ++ GM I N + G SG+ +K ++ I QM + + Sbjct: 442 KSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSGEKLKGVSTHMISQMYNYTNGK 501 Query: 253 DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSL 312 PI GGI T EDA E + GA+ Q+ + ++ G + + L H L +G+ L Sbjct: 502 -IPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKL 560 Query: 313 QEMVGLAN 320 + VG A+ Sbjct: 561 GDAVGRAH 568 >UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacteria RepID=PYRD_CYAP8 Length = 377 Score = 47.8 bits (112), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 89/202 (44%), Gaps = 18/202 (8%) Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPMLAKMTPNIGD- 181 E AD N S P + G Q E + +A++ + P+ K++P++ + Sbjct: 183 ENQADYFVVNVSSP----NTPGLRSLQEGEQLNSILQALQAANQHQKPLFVKISPDLEEE 238 Query: 182 -MCEVALAAKRGGADGIAAINTVKSITNIDLNQKI----GMPIVNGKSSISGYSGKAVKP 236 + + A+ GI A NT +I L +I G I ISG + Sbjct: 239 AILTIIELAQTHCLAGIIATNT--TIKRDRLTTQILPETGNKIQEEAGGISGLPIRDRST 296 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 + FI Q +T +L PI G+GGI T +DA ++ GA+ LQ+ TG + G I+ D+ Sbjct: 297 EIIGFIYQ-KTQGKL---PIIGVGGIFTPDDAWNKIIAGASLLQLYTGWIYQGPWIIPDI 352 Query: 297 ASGLSHYLADQGFDSLQEMVGL 318 GL L G + + VG+ Sbjct: 353 VRGLGDKLKQLGLSHISQAVGI 374 >UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neorickettsia RepID=Q2GEM2_NEOSM Length = 348 Score = 47.8 bits (112), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 90/210 (42%), Gaps = 24/210 (11%) Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR--GSTLPMLA 173 + LA V AD I N S P S D+ Q E++E+ AVK GS + + Sbjct: 154 YARLAAYVSSV-ADYITLNISSPNTVSL---RDM-QKVEILEELLIAVKAAVGSNVRIFI 208 Query: 174 KMTPNIGDMCEV---ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ + EV +LA K A I + T+ ++ K+ G S Sbjct: 209 KVAPDLAEGAEVGIISLALKHKVAGIIVSNTTIGCRESLHSKHKV---------EYGGLS 259 Query: 231 GKAVKPIALRFIQQMR--THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 G + ++ +++M T+ EL G GGI E A + GAA +Q T + Sbjct: 260 GTPLFKLSTGLLRKMYRCTNGEL---VFIGCGGISDAETAYAKIRNGAALIQAYTSFTYH 316 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G+ ++ + L L GF S+ E VG+ Sbjct: 317 GFGLLNQIKKDLVQRLKADGFSSVSEAVGV 346 >UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/Pelodictyon group RepID=B3EIF4_CHLL2 Length = 375 Score = 47.8 bits (112), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 87/216 (40%), Gaps = 34/216 (15%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + DLS T+ G+K NP +SS + E G G VV K++ F Sbjct: 47 IMADLSTTWMGLKLRNPLIAASSGLTGTLEGVKAVASHGAGAVVLKSL-----------F 95 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRR---------------LKEDYPDKVLIA 106 + + +TGF +N + E+ + R L D P +IA Sbjct: 96 EEQIMLETGFAEGQNAQHHYYAQAEDYIREYTRGNALNGYLDLITSCKLAVDIP---VIA 152 Query: 107 SIMGENEQQWEELARLVQEAGADMIECN-FSCPQMTSHAMGSDVGQSPELVEKYCRAVKR 165 SI ++ +W A ++ AGAD +E N F P +S + + +++E R V+ Sbjct: 153 SINCVSQGEWLSFASQIERAGADGLEINIFLSPSDSSRSSTENERLYGDVLENITRVVR- 211 Query: 166 GSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAIN 201 +P+ AK++ + A++ G G+ N Sbjct: 212 ---IPVAAKISSYFSSLAAEAVSLSHSGIRGLVLFN 244 >UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Rickettsiales RepID=B9KHW9_ANAMF Length = 389 Score = 47.8 bits (112), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 48/212 (22%), Positives = 97/212 (45%), Gaps = 20/212 (9%) Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPEL---VEKYCRAVKRGSTLPM 171 ++ E+ R V + I N S P + G E+ V R+V + ++P+ Sbjct: 187 EYAEMVRSVYGL-SSYITINVSSPNTAGLRDLQNRGPLSEILSSVRDARRSVDQAESVPI 245 Query: 172 LAKMTPNIGDMCEVALAAK--RGGADGIAAINTVKSITNI--DLNQKIGMPIVNGKSSIS 227 K+ P+I D + +A + + G+ NT ++ + D N+ I + Sbjct: 246 FLKIAPDISDELKQDIAEEIVKHKISGLIVSNTTTDLSLLGKDRNKSI---------TQG 296 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPI-SGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 G SG+ + ++ + +M + LRD I G GG+ + A + + GA+ +Q+ T ++ Sbjct: 297 GLSGRPLFDLSTTVLSEM--YSLLRDKVILIGCGGVSSGAQALQKIKAGASLVQLYTALV 354 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G+ +V+ + L+ L +GF +++ VG+ Sbjct: 355 YEGFGVVKKINMELAELLTQEGFSKVEQAVGV 386 >UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, putative n=3 Tax=Agaricomycotina RepID=Q5KK62_CRYNE Length = 591 Score = 47.8 bits (112), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 65/228 (28%), Positives = 103/228 (45%), Gaps = 35/228 (15%) Query: 84 PLEENLAALRRLKEDYPDKVLIASIMGENE----QQWEELARLVQEAG--ADMIECNFSC 137 PL NL L L+A +G+N+ ++ R V+ G AD++ N S Sbjct: 204 PLPANLVPPAGLPRSLRAGQLLAVNLGKNKASDPDSNDDYVRGVRTLGPFADVVVINVSS 263 Query: 138 PQMTSHAMGSDVGQSPELVEKYCRAV-------KRGSTLPMLA-KMTPNIGD--MCEVAL 187 P G Q + +E+ V +G+ LP +A K+ ++ + + +VA Sbjct: 264 PNTP----GLRALQGKQQLERLLNDVVEERNKIAQGTGLPKIAVKVASDLSEDELADVAS 319 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG-KSSISGYSGKAVKPIALRFIQQMR 246 A + G +G+ NT +I +LN +V+G + I G SGK + P AL ++ +R Sbjct: 320 AVRSSGVEGVIVSNT--TIRRKELN------LVSGNQDQIGGLSGKPLFPYALNALKTLR 371 Query: 247 THPELR-DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 P L PI G GGI + DA GA+ +QV T +G+R V Sbjct: 372 --PLLPPSIPIIGCGGISSGSDALTMANAGASIVQVYT---SFGFRGV 414 >UniRef50_C0CNF3 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica DSM 10507 RepID=C0CNF3_9FIRM Length = 433 Score = 47.8 bits (112), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 24/59 (40%), Positives = 33/59 (55%), Gaps = 1/59 (1%) Query: 337 PRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 P+I+LDKCVGCG+C C + M K + +TE C+GC +C C V IE+ Sbjct: 296 PKISLDKCVGCGKCAKVCPILAIE-MAGDSKKKKAEVDTEICLGCGVCARNCLVKAIEM 353 >UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G8S8_PHATR Length = 456 Score = 47.4 bits (111), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 82/348 (23%), Positives = 142/348 (40%), Gaps = 44/348 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 +S + G FPNP L++ E+ + D G+G V T+ PR L Sbjct: 91 VSNSVFGKTFPNPIGLAAG-FDKDGEVVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRL 149 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRR------LKEDYPDKV------------LIA 106 V ED G I +E+NL + R K +P + L+ Sbjct: 150 V-EDLGIINRYGFNSQGASTVEKNLKSFRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVG 208 Query: 107 SIMGENEQQWEELARLV-----QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR 161 +G+N+ + + V + AD + N S P T+ S ++ C Sbjct: 209 VNIGKNKNSLDAIGDYVCNIRQLSSLADYMVLNISSPN-TAGLRDLQQANSLRVLLTTCL 267 Query: 162 AVKRGST--LPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGM 217 + T +P+L K+ P++ D + ++A G DGI NT N + Sbjct: 268 TTRNEMTHRVPLLVKLAPDLTDEELDQIANVCLEVGIDGIIITNTT--------NHRPAD 319 Query: 218 PIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRD--FPISGIGGIETWEDAAEFLLLG 275 + + I G SGK VK + I+++ L D PI G+GG+ + DA E L G Sbjct: 320 LLSKHRGEIGGLSGKPVKDQSTECIRRLF---RLTDGKIPIIGVGGVGSGHDAYEKLKAG 376 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 A+ +QV + ++ G ++ + L+ + + G S+ +++G + +I Sbjct: 377 ASLVQVYSMMVYQGPGVISRIRHDLATLMLENGQRSIVDVIGADHEDI 424 >UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobacteria RepID=PYRD_COXB1 Length = 347 Score = 47.4 bits (111), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/136 (27%), Positives = 69/136 (50%), Gaps = 13/136 (9%) Query: 169 LPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 +P+ K+ P++ ++ +A A + +GI A NT S + G + + Sbjct: 212 VPLFLKIAPDLTPEEIQTIATLALQHRIEGIVATNTSCS--------RQGTEKLPNANEA 263 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRD-FPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SGK + P+ L+ ++Q+ H L D PI +GGI + E+A + GA +Q+ TG+ Sbjct: 264 GGLSGKPLFPMTLQVVKQL--HSFLGDEIPIVAVGGIFSGENAQTLINAGARLVQLYTGL 321 Query: 286 MQYGYRIVEDMASGLS 301 + G +V+++ L+ Sbjct: 322 IYEGPELVKNIVEFLT 337 >UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsiales RepID=B3CMR9_WOLPP Length = 355 Score = 47.4 bits (111), Expect = 0.001, Method: Compositional matrix adjust. Identities = 75/342 (21%), Positives = 140/342 (40%), Gaps = 63/342 (18%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWG----GVVFKTIGFFIANEV 57 L K L++ F G K +P L++ N E+ G+G G V K + Sbjct: 48 LPKSLNVNFFGNKIRSPVGLAAGFDKNA-EVVKPMLSFGFGFIEAGTVTKHPQY---GNK 103 Query: 58 SPRFDHLVKEDTGFI---GFKN------MEQIAEHPLEENLAALRRLKEDYPDKVLIASI 108 PR L+K D G I GF N ++QI+E L + + Sbjct: 104 KPRIFRLIK-DEGIINRLGFNNKGVDYFLKQISETKLGNCIFGIN--------------- 147 Query: 109 MGENEQQWEELARLVQ-----EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC--- 160 +G N ++++ V ++ I N S P + + + +L++ Sbjct: 148 IGRNSTSKDQISDYVDLIKIVYGKSNYIVLNISSPNTPNLRDLHNKQELSKLLKSITLTR 207 Query: 161 RAVKRGSTLPMLAKMTPNIG-----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 +++ ++P++ K++P+I ++ E+ L K DG+ NT +I+ + Sbjct: 208 KSIDSSESIPIILKISPDIDQQTKENIAELTLEYK---IDGLIVSNT--TISRDSYYNES 262 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 G G SG+ + ++ + M + R I G GGI + DA E + G Sbjct: 263 G-----------GLSGRPLFQLSTELLSDMYKLTKSRILLI-GCGGISSGVDAYEKIKAG 310 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 A+ +Q+ T ++ G+++V + L+ + GF ++ E VG Sbjct: 311 ASLVQLYTALVYQGHQVVNKINLELAELVKRDGFSNITEAVG 352 >UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria RepID=PYRD_FLAPJ Length = 350 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 37/133 (27%), Positives = 63/133 (47%), Gaps = 24/133 (18%) Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINT------VKSITNIDLNQKIGMPIVN 221 P+L K+ P++ + + ++ K GI A NT ++SI I++ G P+ N Sbjct: 223 PILLKIAPDLTNEQLLDIIDIVKTTKIAGIIATNTTISREGLQSINRIEMGGLSGKPLTN 282 Query: 222 GKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 + + +RF+ Q + FPI G+GGI +DA E L GA+ +Q+ Sbjct: 283 RSTEV------------IRFLSQKSN----KAFPIIGVGGIHCVQDAIEKLEAGASLIQL 326 Query: 282 TTGIMQYGYRIVE 294 TG + G +V+ Sbjct: 327 YTGFIYEGPALVK 339 >UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira RepID=Q056I9_LEPBL Length = 384 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 81/197 (41%), Gaps = 21/197 (10%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD-----M 182 AD N S P L++ + + +P+ K P++ + Sbjct: 190 ADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKFAPDMETKDLEAL 249 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E +L+ K DG+ NT ID + P V + +SG P+ R Sbjct: 250 LESSLSLK---IDGVVLTNTT-----IDKSSLKAYPNVEKEGGLSGV------PLKNRST 295 Query: 243 QQMRTHPEL--RDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + +R + R PI G+GGI++ + A E +L GA +Q+ TG + G + + L Sbjct: 296 EFVRVAYRILKRRIPIIGVGGIDSEKAALEKILAGADLIQIYTGYIYQGPFLPLKILEFL 355 Query: 301 SHYLADQGFDSLQEMVG 317 +L +Q ++ ++VG Sbjct: 356 DRFLKEQDLKTVSDLVG 372 >UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B240E Length = 338 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 83/200 (41%), Gaps = 17/200 (8%) Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAKMTPNIG 180 ++ A ++E N SCP G + PE +E + + +P KM P++ Sbjct: 139 IIDNKLASIVEINISCPNA-----GKESFIYPETLEILLKEIDTIDRNIPFWIKM-PHLY 192 Query: 181 DMCEVALAAK---RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 D+ + K + G+ N VK T +++ + I G SG+ + Sbjct: 193 DINQFDSLLKVIVKHNIQGVTIANLVKDRTKVEIKDPLTDEIR------GGLSGEPTRKH 246 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 +L I+ + I G+GGI + EDA + GA+ + + TG+ G +V Sbjct: 247 SLELIRYAYKNYG-NKLTIVGVGGIFSAEDAYAKIKAGASLVGLITGLFFEGPHLVGRAN 305 Query: 298 SGLSHYLADQGFDSLQEMVG 317 L L + GF S+ E VG Sbjct: 306 RELVKLLKNDGFSSISEAVG 325 >UniRef50_B8FE57 4Fe-4S ferredoxin iron-sulfur binding domain protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FE57_DESAA Length = 378 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/57 (40%), Positives = 30/57 (52%), Gaps = 4/57 (7%) Query: 339 INLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 ++ +KCV CG C C G QAM E +P N + C+GC +C H CP I L Sbjct: 311 VDTEKCVSCGTCAEKC---GTQAMTQGEDG-SPSLNKDLCIGCGVCAHFCPENAISL 363 >UniRef50_B7AS28 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus ATCC 43243 RepID=B7AS28_9BACE Length = 184 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 25/72 (34%), Positives = 35/72 (48%), Gaps = 6/72 (8%) Query: 325 PAEDLDRSYI-VYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLL 383 PA L + ++ YP++N D CVGCGRC SC A K + H + C+ C Sbjct: 114 PATMLMKHFLKSYPKVNPDICVGCGRCAESC-----PAHIIKIKDKKAHFTKKGCISCFC 168 Query: 384 CGHVCPVGCIEL 395 C +CP I + Sbjct: 169 CQEMCPAKAISV 180 >UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae RepID=A9HBE5_GLUDA Length = 357 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 77/342 (22%), Positives = 134/342 (39%), Gaps = 58/342 (16%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD--- 62 L++ G++FPNP +++ N + A G+G F A V+PR Sbjct: 46 LAVRALGLRFPNPIGIAAGFDKNALVVRPLAR-IGFG--------FVEAGTVTPRPQPGN 96 Query: 63 -----HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPD------KVLIASI 108 + ED I GF N ++ L RL P +V + + Sbjct: 97 PRPRLFRLDEDRAIINRMGFNNQG------IDRFAVRLARLHRVSPAGRHAGARVPVGAN 150 Query: 109 MGEN------EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 +G N E+ + L V+ AD + N S P + + L++ A Sbjct: 151 LGINKFGADPERDYPRLVGRVKHY-ADYVVLNLSSPNTPGLRDLQEASRLGALLQAIGEA 209 Query: 163 VKRGSTLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 P+L K++P++ D+ + AA GGA G+ +TN +++ G+ Sbjct: 210 --HPDRPPLLVKLSPDLARDDIGPIVEAAIAGGAQGLI-------VTNTTISRPAGLRSP 260 Query: 221 NGKSSISGYSGKAVKPIA---LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAA 277 + + G SG+ ++P+A R + Q+ + GGIET D + + GA Sbjct: 261 HAGEA-GGLSGRPLRPLAADIFRAVAQVAAG----RLALVACGGIETGADIVDRVRAGAD 315 Query: 278 TLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 +Q+ + G IV + L +GF++L + G A Sbjct: 316 LVQLYSAFAYEGPGIVRRLKRETVRVLNAEGFETLADAKGTA 357 >UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (class) RepID=B9L4A8_THERP Length = 374 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 84/338 (24%), Positives = 142/338 (42%), Gaps = 55/338 (16%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFDHL 64 L + + FPNP L++ V E A + G+G V T+ PR Sbjct: 65 LRVEVGDLTFPNPIGLAAG-VDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRF 123 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALR-RL-KEDYPDKVLIASIMGENEQQWEELA 120 +++T +GF + + +AA+R RL +P V I +G+N W L Sbjct: 124 PEDETLVNALGFPS----------DGVAAVRARLVGRWFPGPVGIN--LGKN--AWTPLE 169 Query: 121 RLVQE---------AGADMIECNFSCPQ---MTSHAMGSDVGQSPELVEKYCR---AVKR 165 + V + AD + N S P + G + Q V++ R A++R Sbjct: 170 QAVVDYCATLVALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQR 229 Query: 166 GSTLPMLAKMTPNI-----GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 P+ K++ ++ D E+A+A GADG+ NT +ID + + Sbjct: 230 ARPRPLFVKVSLDLDAGALADAIEIAVAV---GADGLILGNT-----SIDPSLRPA---- 277 Query: 221 NGKSSI-SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 G ++ G SG+ ++ A+ + R IS +GG+ +D + L LGA + Sbjct: 278 -GAGALPGGVSGRPLRKRAVELLSNAADRAGGRLALIS-VGGVLETDDVIQRLRLGADLV 335 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 QV TG++ G + + GL YL +QG S++ + G Sbjct: 336 QVYTGLVFRGPALPAVLLRGLLRYLDEQGLPSVRALRG 373 >UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=Plasmodium (Vinckeia) RepID=Q7RLG4_PLAYO Length = 512 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 64/277 (23%), Positives = 115/277 (41%), Gaps = 43/277 (15%) Query: 73 GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-------ENEQQWEELARLVQE 125 GF N I + ENL + R+ +E+ DK+L I+G E ++L + + Sbjct: 246 GFNN---IGCDKVTENLISFRKKQEE--DKLLSKHIVGVSIGKNKYTENIVDDLKYSIYK 300 Query: 126 AG--ADMIECNFSCPQ-------MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM----- 171 AD I N S P S+ + + + + + K + G M Sbjct: 301 IARYADYIAINVSSPNTPGLRDNQESNKLKNIILFVKQEINKIEESGHNGENFWMNTTKK 360 Query: 172 ----LAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 K+ P++ + ++A G DG+ I+N +N+ M I + + Sbjct: 361 KPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMI-------ISNTTINK---MDIKSFEDK 410 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SGK +K ++ I M + + PI GGI T DA E + GA+ Q+ + + Sbjct: 411 KGGVSGKKLKDLSTNLISDMYIYTN-KQIPIIASGGILTGADALEKIEAGASVCQLYSCL 469 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 + G + + ++ L +G+ +L+E +G +NN Sbjct: 470 VFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHNN 506 >UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaproteobacteria RepID=PYRD_SHEWM Length = 340 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 35/137 (25%), Positives = 70/137 (51%), Gaps = 11/137 (8%) Query: 162 AVKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 A K G +P+ K+ P++ D + ++A + + DG A NT S + G+ Sbjct: 205 AQKHGKYVPIALKIAPDLSDEEIQKIADSLIKNQFDGAIATNTTLS--------RDGVSG 256 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 + + G SGK + ++ I+++ + + PI G+GGI + DA + L GA+ + Sbjct: 257 LMNANETGGLSGKPLNLLSTSVIKKLSSCLNGQ-IPIIGVGGINSAADAIDKLDAGASMV 315 Query: 280 QVTTGIMQYGYRIVEDM 296 Q+ +G + G ++++D+ Sbjct: 316 QIYSGFIYQGPKLIKDI 332 >UniRef50_A6CFX5 Putative uncharacterized protein n=1 Tax=Planctomyces maris DSM 8797 RepID=A6CFX5_9PLAN Length = 354 Score = 46.6 bits (109), Expect = 0.002, Method: Compositional matrix adjust. Identities = 62/209 (29%), Positives = 87/209 (41%), Gaps = 38/209 (18%) Query: 101 DKVLIASIMGENEQQW--EELA-------RLVQEAGADMIECNFSCPQMTSHAMGSDVGQ 151 +K L S++G + W E+LA + E+GAD +E NFSCP + + + Q Sbjct: 144 EKRLSVSVVGSLQPDWSLEDLADDYARCAKWAIESGADCVETNFSCPNVCTR--DGQLYQ 201 Query: 152 SPELVEKYCRAVKRGS-TLPMLAKMTPNIGDMCEVA-----LAAKRGGADGIAAINTVKS 205 PE VK S T+P L K IG + + A L A A GI N+V + Sbjct: 202 QPEAAALVASRVKAVSGTVPYLIK----IGHLSQKAEAHAFLQAVLPFAAGIVMTNSVAT 257 Query: 206 ITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPEL-----RDFPISGI- 259 D G P+ +G+ G G A + +L Q+R EL D P + Sbjct: 258 TVVDDQ----GTPLFSGEQ--RGICGAATRQASL---NQLRLFTELIAELPADQPRPDLI 308 Query: 260 --GGIETWEDAAEFLLLGAATLQVTTGIM 286 GGI + D FL GA + T M Sbjct: 309 SCGGIGSASDVRTFLAAGANATHLATAAM 337 >UniRef50_D1Y5W8 4Fe-4S ferredoxin, iron-sulfur binding domain protein n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y5W8_9BACT Length = 390 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 21/69 (30%), Positives = 34/69 (49%) Query: 325 PAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLC 384 PA + V+ ++ +KC+GCGRC+ +C + + T H + E C+GC C Sbjct: 186 PARGKKAQHAVHLEVDEEKCIGCGRCFRNCPGHAITMEKDAAGKTTSHIHAEPCLGCCEC 245 Query: 385 GHVCPVGCI 393 VCP + Sbjct: 246 MTVCPTQAV 254 >UniRef50_UPI0001B4E622 dihydroorotate dehydrogenase n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4E622 Length = 230 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 81/201 (40%), Gaps = 26/201 (12%) Query: 131 IECNFSCPQMTSHAMGSDVGQSPELVE-----KYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 +E N P G + G +L E +Y R V P++ K+ D+ + Sbjct: 27 VEINIGAPH------GREAGAVRQLTEADGVARYVRTVSAAMDRPLIVKLPGQASDILGM 80 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A AA GAD + I + N + P + S G + PI+L ++ + Sbjct: 81 ARAAVDNGADAVTLIGRLGGFVP---NLETWEPELG---SWGAVGGPWMLPISLYWLSKC 134 Query: 246 RTHPELRDF----PISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 R RD P+ G G D A FLL GA +++ + ++ G + ++ L Sbjct: 135 R-----RDLGDGTPLIGTNGARDGLDVARFLLSGAHAVELASLLLLRGAPALTEVLVQLG 189 Query: 302 HYLADQGFDSLQEMVGLANNN 322 YL +G L +++G + + Sbjct: 190 AYLDARGIGRLDDIIGASADR 210 >UniRef50_C1SIN0 Putative uncharacterized protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SIN0_9BACT Length = 175 Score = 45.8 bits (107), Expect = 0.003, Method: Compositional matrix adjust. Identities = 43/183 (23%), Positives = 79/183 (43%), Gaps = 30/183 (16%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 D+S+ + G++ +P SS + + +A D G G VV K++ F+ Sbjct: 3 DISVDYMGLQLTSPVIAGSSTLTKDMDNLRRAEDAGAGAVVLKSL-----------FEEE 51 Query: 65 VKEDTGFI---------GFKNMEQIAEHPLEENLAALRRLKEDYPDKV---LIASIMGEN 112 ++ + G + + + + E L ++R DKV +IASI E Sbjct: 52 IRLEAGTVEETYHPEAYDYMTADAAMVYGSGEYLEYVKRA----ADKVTIPVIASINCEG 107 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 + W + A ++EAGAD IE N + + G ++ E + + VK+ ++P+ Sbjct: 108 TKWWAKFAGDIEEAGADAIELNIAFMPFEADITGQ---ETEERYLEVVKEVKKTVSIPVG 164 Query: 173 AKM 175 KM Sbjct: 165 VKM 167 >UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondrial n=4 Tax=Plasmodium RepID=PYRD_PLAF7 Length = 569 Score = 45.8 bits (107), Expect = 0.003, Method: Compositional matrix adjust. Identities = 36/121 (29%), Positives = 59/121 (48%), Gaps = 16/121 (13%) Query: 207 TNIDLNQKIGMPIVNGKSSIS----------GYSGKAVKPIALRFIQQMRTHPELRDFPI 256 TNID GM I N + I+ G SG +K I+ +FI +M + + PI Sbjct: 449 TNID-----GMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICEMYNYTN-KQIPI 502 Query: 257 SGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMV 316 GGI + DA E + GA+ Q+ + ++ G + + L+H L +G+ +L+E + Sbjct: 503 IASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGYYNLKEAI 562 Query: 317 G 317 G Sbjct: 563 G 563 >UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular organisms RepID=PYRD_RHORT Length = 367 Score = 45.8 bits (107), Expect = 0.003, Method: Compositional matrix adjust. Identities = 83/339 (24%), Positives = 139/339 (41%), Gaps = 61/339 (17%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ + G +F NP L++ N E+ +D G+G V T+ A PR L Sbjct: 44 LACSLWGRRFANPLGLAAGFDKNG-EVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRL 102 Query: 65 VKEDT--GFIGFKN--MEQIAEHPLEENLAALRRLKEDYPDKVLIASI---------MGE 111 ++ +GF N ME +A R P VL ++ G+ Sbjct: 103 TQDRAVINRMGFNNQGMEAMAA-----------RFVRARPRGVLGINLGKNKTTEDAAGD 151 Query: 112 NEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPE--LVEKYCRAVKR---G 166 E +LA L AD + N S P + + + G+ P L+ + A+ G Sbjct: 152 YEAGIAKLAPL-----ADYLVINVSSPN--TPGLRALQGREPLSLLIARARAALDAACPG 204 Query: 167 STLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 P+L K+ P++ D M ++A A GG DG+ NT I KS Sbjct: 205 LRPPLLLKVAPDLTDEDMADIAEVALGGGLDGLICTNTT---------------IARPKS 249 Query: 225 SISGYSGK--AVKPIALRFIQQM---RTHPELRD-FPISGIGGIETWEDAAEFLLLGAAT 278 +S ++G+ + + LR+ + R + + P+ G+GGI +A + GA+ Sbjct: 250 LVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDGAEAYARIRAGASL 309 Query: 279 LQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 +Q+ + ++ G +V + L+ L GF S+ E VG Sbjct: 310 IQIYSALVYEGPGLVGRIKRDLAQRLRADGFASVAEAVG 348 >UniRef50_B8FAU6 Nitrite and sulphite reductase 4Fe-4S region n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FAU6_DESAA Length = 287 Score = 45.4 bits (106), Expect = 0.004, Method: Compositional matrix adjust. Identities = 26/61 (42%), Positives = 28/61 (45%), Gaps = 5/61 (8%) Query: 337 PRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 P NLD CV CG C SC D QA+ K P + C GC C CP CI L Sbjct: 170 PDFNLDNCVDCGDCAESCPD---QAI--IMKDDRPVYDPHACQGCFNCSQACPADCISLE 224 Query: 397 E 397 E Sbjct: 225 E 225 >UniRef50_Q1AXJ2 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AXJ2_RUBXD Length = 403 Score = 45.4 bits (106), Expect = 0.004, Method: Compositional matrix adjust. Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 4/54 (7%) Query: 337 PRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPV 390 P +N D C+ C +C+I C D + E +E+ P N E C GC +C VCPV Sbjct: 286 PVVNFDTCIKCRQCWIDCPD---ECFEVTEEGLHP-INYEYCTGCGICSQVCPV 335 >UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria RepID=PYRD_DEIRA Length = 369 Score = 45.1 bits (105), Expect = 0.005, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 90/217 (41%), Gaps = 23/217 (10%) Query: 112 NEQQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-- 167 NE E+ + V+ G AD N S P LV V+ G Sbjct: 163 NEDAAEDYRKCVRALGDLADAFVVNVSSPNTPGLRALQAADDLAALVRAVLDEVEAGRVR 222 Query: 168 TL---PMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 TL P+L K+ P++ D A GA G+ NT S + G+ N Sbjct: 223 TLRRPPVLVKLAPDLHPADFEASVGAVLDAGASGLIISNTTLS--------RGGLSHPN- 273 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELR--DFPISGIGGIETWEDAAEFLLLGAATLQ 280 + G SG+ P+ R + +R L PI G+GG+ + EDA LL GA ++ Sbjct: 274 REQAGGLSGR---PLTDRSTELVRDAYRLTRGQVPIVGVGGVFSAEDAYAKLLAGADLVE 330 Query: 281 VTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 V + ++ G +V ++ +GL L G ++ ++VG Sbjct: 331 VYSALIYRGPGLVREINAGLVKLLERDGVRNIADVVG 367 >UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9TAL5_RICCO Length = 309 Score = 45.1 bits (105), Expect = 0.005, Method: Compositional matrix adjust. Identities = 21/48 (43%), Positives = 32/48 (66%) Query: 254 FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 PI +GGI T +DAA+ L GA+ +QV TG+MQ G +++ M + L+ Sbjct: 256 IPIVAVGGIRTPQDAADRLAAGASLVQVHTGLMQSGPKLISQMNAFLA 303 >UniRef50_C3WAR9 MinD family protein n=1 Tax=Fusobacterium mortiferum ATCC 9817 RepID=C3WAR9_FUSMR Length = 280 Score = 45.1 bits (105), Expect = 0.005, Method: Compositional matrix adjust. Identities = 23/60 (38%), Positives = 34/60 (56%), Gaps = 13/60 (21%) Query: 338 RINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGE 397 +I+ +KC+ C RCY C +AM+ N +KC GC +C ++CPVG IE+ E Sbjct: 64 KIDSEKCIHCNRCYEYC---KFEAMD----------NVQKCEGCGVCEYICPVGAIEMIE 110 >UniRef50_Q5JHV8 4Fe-4S cluster-binding protein n=1 Tax=Thermococcus kodakarensis RepID=Q5JHV8_PYRKO Length = 162 Score = 45.1 bits (105), Expect = 0.005, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 2/76 (2%) Query: 322 NIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME-WSEKTRTPHCNTEKCVG 380 +++P E L V P+I+ + C+GCG C C G QA++ + E R N KC Sbjct: 8 SLIPLEHLPNGLGV-PQIDPELCIGCGACVNVCPAGALQAIDDYMEGIRKISLNIGKCTP 66 Query: 381 CLLCGHVCPVGCIELG 396 C C VCP G I++ Sbjct: 67 CTRCEEVCPTGAIKIA 82 >UniRef50_Q6SFW7 NifR3/Smm1 family protein n=1 Tax=uncultured marine bacterium 578 RepID=Q6SFW7_9BACT Length = 322 Score = 45.1 bits (105), Expect = 0.006, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 80/196 (40%), Gaps = 30/196 (15%) Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRR--LKEDYPDKVLIASIMGENEQQWEE 118 F + +E + M + +H L N + R E P + IA G Q+ E Sbjct: 25 FRMICREQGAALTTSEMVVMQKHLLNTNKSKHRLDFRSEQSPISIQIA---GSESQELAE 81 Query: 119 LARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM- 175 A+ E GAD+I+ N CP ++ + A GS + ++ +LVE +AV +P+ KM Sbjct: 82 SAKQALEFGADIIDINMGCPAKKVCNKAAGSALMKNEKLVEDIIKAVVNAVNIPVTLKMR 141 Query: 176 ---------TPNIGDMCE---VALAAKRGGA-----DGIAAINTVKSITNIDLNQKIGMP 218 P I + E + + A G +G A +TVK I I + +P Sbjct: 142 TGWNEENKNAPTIAKIAEDNGIKMLAIHGRTRAQKYNGDAEYDTVKKIKGI-----VSIP 196 Query: 219 IVNGKSSISGYSGKAV 234 +V S K V Sbjct: 197 VVANGDITSAQKAKKV 212 >UniRef50_B3QWF2 TIM-barrel protein, nifR3 family n=26 Tax=Bacteroidetes/Chlorobi group RepID=B3QWF2_CHLT3 Length = 402 Score = 44.7 bits (104), Expect = 0.006, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 93/221 (42%), Gaps = 37/221 (16%) Query: 59 PRFDHLVKE---DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 P F L K D F F + + + H ++ R+L ++ + I G + Sbjct: 67 PSFRRLCKHYGADIVFTEFISSDGLIRHAVKSK----RKLDVFDDERPVAIQIFGNQIEP 122 Query: 116 WEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 E A++ + AG D I+ N+ CP ++ GS + P+L+EK AV + LP+ A Sbjct: 123 MVEAAQMAEAAGPDFIDINYGCPAKKVAGKGAGSGLLCQPDLMEKITDAVVKAVRLPVTA 182 Query: 174 KMTPNIGDMCEVALAAKRGGAD--GIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K R G D I+ ++TV+ + + Q + ++G++ Y G Sbjct: 183 KT---------------RIGWDERSISILDTVRRLEGCGI-QALS---IHGRTRAQMYKG 223 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL 272 +A +I + + E+ PI G G I T EDA Sbjct: 224 RA----DWSWIARAK---EVATIPIIGNGDIWTAEDAKRMF 257 >UniRef50_B0VJW9 Putative iron-sulfur cluster-binding protein n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VJW9_9BACT Length = 374 Score = 44.7 bits (104), Expect = 0.006, Method: Compositional matrix adjust. Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 22/191 (11%) Query: 211 LNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWED--- 267 + +I I++G + + G A KP + + P L D+ S I G + + Sbjct: 194 IGNRITYSIIDGITGMDGNGPSAGKPHHFGLLFGSTSIPAL-DYVASRIMGFQLKDVPYL 252 Query: 268 AAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD-QGFDSLQEMVGLANNNIVPA 326 ++ ++ G Q+ + YRI + AD +Q+ + + + Sbjct: 253 SSALIMDGILPSQIKIPVSFRNYRIPD----------ADINSVKVIQKTLKYVPD--IAR 300 Query: 327 EDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGH 386 + + Y YP ++ ++C CG C SC +A+ W T+ P+ + E+C+ CL C Sbjct: 301 KAFRKVYYFYPAVS-ERCKQCGICVKSC---PVKAISWQNDTK-PYIHKEQCIKCLCCHE 355 Query: 387 VCPVGCIELGE 397 +CP I++ + Sbjct: 356 LCPYQAIDIKK 366 >UniRef50_A0LJ96 Putative TIM-barrel protein, nifR3 family n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LJ96_SYNFM Length = 352 Score = 44.7 bits (104), Expect = 0.006, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 65/141 (46%), Gaps = 20/141 (14%) Query: 96 KEDYPDKVLIA-SIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQS 152 ++ +P V +A + G + E ARLV++ GA +I+ N CP ++ G+ + + Sbjct: 71 RQQHPVGVPLAVQVFGRDPAVMAEAARLVEQGGAALIDINAGCPVRKVVRQGAGAILLKD 130 Query: 153 PELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLN 212 P+ + AVKR ++P+ K+ R G D A N V + ++ Sbjct: 131 PDRLAAMVEAVKRAVSVPVTVKI---------------RVGWDN--AANGVAGLARQLVS 173 Query: 213 QKIGMPIVNGKSSISGYSGKA 233 + V+G+++ YSG+A Sbjct: 174 AGVDAITVHGRTAAQMYSGRA 194 >UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromonas sp. RCC299 RepID=C1EIH8_9CHLO Length = 488 Score = 44.7 bits (104), Expect = 0.007, Method: Compositional matrix adjust. Identities = 43/159 (27%), Positives = 72/159 (45%), Gaps = 18/159 (11%) Query: 170 PMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+L K+ P++ GD+ +V AA DGI + S T I + + G++ Sbjct: 339 PVLLKIAPDLTDGDIKDVVAAATSCAVDGI-----IVSNTTIARPEDVAAHARGGEAG-- 391 Query: 228 GYSGKAV----KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 G SGK + + R Q P+ G GG+ + DA E + GA+ +Q+ T Sbjct: 392 GLSGKPLMDPSTEVLFRVYQLTGGK-----IPLVGCGGVASGRDAYEKIRAGASLVQMYT 446 Query: 284 GIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 G +V M + L+ L + G++S+ E +G A+ Sbjct: 447 AFAYAGPALVPAMKAELAACLREDGYESVAEAIGAAHRK 485 >UniRef50_D2C814 4Fe-4S ferredoxin iron-sulfur binding domain protein n=10 Tax=cellular organisms RepID=D2C814_THENR Length = 139 Score = 44.3 bits (103), Expect = 0.007, Method: Compositional matrix adjust. Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 14/86 (16%) Query: 324 VPAEDLDRSYI-VYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK------TRTPHCNTE 376 VP +DR I YP I+ DKCV CG C+++C G + ++ +K R +C Sbjct: 25 VPWWGVDRKEIEWYPTIDYDKCVTCGICFVTC---GRRVFDFDKKEGKVIVARPYNCM-- 79 Query: 377 KCVGCLLCGHVCPVGCIELGEVKFKK 402 V C C ++CP G I + + K Sbjct: 80 --VACQTCMNLCPTGAISFPDASYIK 103 >UniRef50_Q3A324 Dihydrouridine synthase n=10 Tax=Desulfuromonadales RepID=Q3A324_PELCD Length = 342 Score = 44.3 bits (103), Expect = 0.009, Method: Compositional matrix adjust. Identities = 37/133 (27%), Positives = 61/133 (45%), Gaps = 8/133 (6%) Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYP-DKVLIASIMGENEQQWEELARLVQEAGADM 130 IG E I+ + L A R L P D+ L + GEN + + + V+ G D+ Sbjct: 53 IGLAFTEMISANGLVLGGDATRDLLASTPSDRPLGIQLFGENPKYLSQACKQVESHG-DL 111 Query: 131 IECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG----DMCE 184 I+ N CP ++ GS + Q+P V + A++R + LP+ K+ + E Sbjct: 112 IDLNIGCPVKKVVRSGAGSALMQTPARVAQIIAAMRRATHLPLTVKIRAGWDASHINFLE 171 Query: 185 VALAAKRGGADGI 197 +A A++ G D I Sbjct: 172 IAHIAEQEGVDAI 184 >UniRef50_C5EQJ3 NADH oxidase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EQJ3_9FIRM Length = 641 Score = 44.3 bits (103), Expect = 0.009, Method: Compositional matrix adjust. Identities = 36/112 (32%), Positives = 52/112 (46%), Gaps = 9/112 (8%) Query: 50 GFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI- 108 G+ IA +SP + V E G +E A +E A R DYP + I++ Sbjct: 170 GYLIAQFLSPFSNRRVDEYGG-----TLENRARFAVETVKAVKERAGWDYPVLLRISATE 224 Query: 109 ---MGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVE 157 G N +Q + + RLV++AGAD I C+ S P + + S QS VE Sbjct: 225 FIDQGMNVEQAKAICRLVEQAGADAINCSQSGPATFYNTVPSFYVQSGAFVE 276 >UniRef50_Q7X346 Putative uncharacterized protein n=1 Tax=uncultured Acidobacteria bacterium RepID=Q7X346_9BACT Length = 355 Score = 44.3 bits (103), Expect = 0.009, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 5/91 (5%) Query: 112 NEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRGST- 168 +E W A LV+ GAD ++ NF CP T +G+ +G+ P+ + + A+K T Sbjct: 64 DETAWA--AALVESRGADFVDINFGCPIDYFTRKGLGASIGRQPQRMRRLVEAIKGSVTN 121 Query: 169 LPMLAKMTPNIGDMCEVALAAKRGGADGIAA 199 +P+ AK+ D L + DG AA Sbjct: 122 IPVTAKIRLGWNDDDRNYLQQAQAAVDGGAA 152 >UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=PYRD_AKKM8 Length = 348 Score = 43.9 bits (102), Expect = 0.010, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 72/175 (41%), Gaps = 16/175 (9%) Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELV-----EKYCRAVKRGSTLPMLAKMTPNIGD- 181 AD I NFS P + L+ E+ A + G +P+ K+ P++ D Sbjct: 170 ADYIAINFSSPNTPGLRDLQAAEPAARLLASLKSEQSNLAAETGRHVPIFMKVAPDVTDE 229 Query: 182 -MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + E++ G DG+ A NT S ++ N + G SG + + Sbjct: 230 HIAELSRVFLDEGLDGLIATNTTLSRVGVEANPR--------HEEAGGLSGAPLTERSTE 281 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 I + + R PI G+GGI DA + GA+ +Q+ TG + G ++ + Sbjct: 282 VIGAFASELKGR-IPIIGVGGIMNGVDAVAKIKAGASLVQLYTGFVYRGPDLIRE 335 >UniRef50_D1PSC3 4Fe-4S ferredoxin, iron-sulfur binding protein n=3 Tax=Bacteria RepID=D1PSC3_9FIRM Length = 247 Score = 43.9 bits (102), Expect = 0.010, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 56/123 (45%), Gaps = 28/123 (22%) Query: 289 GYRIVEDMASGLSHYLADQ---------------GFDSLQEMVGLANNNIVPAEDLDRSY 333 G+R+V +A+ H +A Q GF + + A + PA +R Y Sbjct: 101 GFRVVAGVAALAEHSIARQYAAGRPNEADKAVLRGFRTQIQAKLDAGEDTAPALPGNRPY 160 Query: 334 ------IVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHV 387 + PR + +C+ CGRC +C G A++ ++ +T + +C+GC+ C + Sbjct: 161 KPGMARAMVPRTS-KRCIDCGRCAAACPTG---AIDAADPRQT---DPARCIGCMRCVRL 213 Query: 388 CPV 390 CPV Sbjct: 214 CPV 216 >UniRef50_B6W8L3 Putative uncharacterized protein n=1 Tax=Anaerococcus hydrogenalis DSM 7454 RepID=B6W8L3_9FIRM Length = 74 Score = 43.9 bits (102), Expect = 0.010, Method: Composition-based stats. Identities = 25/77 (32%), Positives = 40/77 (51%), Gaps = 16/77 (20%) Query: 253 DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSL 312 + PI G+GGI +W+DA EF++ GA+ +QV T + +E + GL+ Y+ Sbjct: 10 NIPIMGMGGITSWQDALEFIMAGASIVQVGTATFMNPKKSLE-IIDGLNKYV-------- 60 Query: 313 QEMVGLANNNIVPAEDL 329 N N+V +DL Sbjct: 61 -------NENMVSIKDL 70 >UniRef50_A9KI98 4Fe-4S ferredoxin iron-sulfur binding domain protein n=1 Tax=Clostridium phytofermentans ISDg RepID=A9KI98_CLOPH Length = 697 Score = 43.9 bits (102), Expect = 0.011, Method: Compositional matrix adjust. Identities = 33/109 (30%), Positives = 45/109 (41%), Gaps = 9/109 (8%) Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRI 339 Q T + Y + + L Y ++ DSL E+VG A +D+ +I Sbjct: 263 QSNTSLTAYSIKHPNKVNKQLKKY-REELTDSLYELVG--------AFGIDQPVNCPTKI 313 Query: 340 NLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVC 388 +C GC C C G Q + E PH N EKC+ C LC VC Sbjct: 314 TRGECCGCYACKEVCPTGAIQMLMDREGFYYPHVNKEKCIHCGLCERVC 362 >UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVX7_9BACT Length = 356 Score = 43.9 bits (102), Expect = 0.012, Method: Compositional matrix adjust. Identities = 36/133 (27%), Positives = 69/133 (51%), Gaps = 8/133 (6%) Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+L K++P++ D + EV DGI A+N S ++ +++ I +G+ S + Sbjct: 214 PILLKISPDLPDPLIDEVTDLMLSTPLDGIVAVNGTFSRKGLETDEETLDEIGSGRLSGA 273 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 + +A++ +R I + R+H +PI G+GG+ D L GA+ +Q+ TG + Sbjct: 274 PLTQRAIE--VVRRIHR-RSHGA---YPIIGVGGLMNARDVKAMLAAGASLVQLYTGYIY 327 Query: 288 YGYRIVEDMASGL 300 G +V+++ L Sbjct: 328 EGPSLVKEICRAL 340 >UniRef50_Q12W37 4Fe-4S cluster-binding protein n=7 Tax=Methanosarcinaceae RepID=Q12W37_METBU Length = 379 Score = 43.9 bits (102), Expect = 0.012, Method: Compositional matrix adjust. Identities = 22/70 (31%), Positives = 33/70 (47%), Gaps = 5/70 (7%) Query: 333 YIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGC 392 + + P IN C CG C ++C +A+E + N EKC+ C C +CP G Sbjct: 306 FTIRPFINTSSCTLCGSCVLNC---SPKAIEQEDGKL--QINDEKCILCYCCRELCPSGA 360 Query: 393 IELGEVKFKK 402 +E+ F K Sbjct: 361 VEMKSSLFAK 370 >UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus cereus RepID=C2QE06_BACCE Length = 350 Score = 43.9 bits (102), Expect = 0.012, Method: Compositional matrix adjust. Identities = 74/337 (21%), Positives = 126/337 (37%), Gaps = 59/337 (17%) Query: 10 FCGVKFPNPFCLSSSPVGNCYEMCAKAY----DTGWGGVVFKTIGFFIANEVS----PRF 61 +KFPNP L++ ++ A Y G+G V +G S PR Sbjct: 42 LLDIKFPNPIGLAAG-----FDKFADVYPGLASLGFGSV---EVGSITPKPQSGNPKPRL 93 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + EDT I ++N L R + + +G+N+ A Sbjct: 94 -YRLPEDTALINRMGFNSEGLDRAKQNFMTLPR------PNIPLGINLGKNKDTPNSDAT 146 Query: 122 LVQEAG-------ADMIECNFSCPQMT-----------SHAMGSDVGQSPELVEKYCRAV 163 L + G D N S P + S + + EL +K+ + Sbjct: 147 LDYQKGLETLYSYGDYFVINISSPNTEGLRDLQYVDTLKPLLASILDKRNELCKKHNQY- 205 Query: 164 KRGSTLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVN 221 P++ K+ P++ + V + D + A NT S TN LN K Sbjct: 206 -----RPIILKIAPDLTPEQLEGVISIIQEVKIDAVIAANTTISRTN--LNSKF------ 252 Query: 222 GKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 + G SGK + + I ++ + + PI G GG+ T EDA E + GA+ +Q+ Sbjct: 253 -QKQNGGLSGKPLNHRSTEIISKIYRQTQ-GNLPIIGSGGVFTGEDAYEKIKSGASLIQI 310 Query: 282 TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 T ++ G + + + + L G ++ E +GL Sbjct: 311 YTSMIYRGPSVAKHINQEILTLLEKDGLTNITEAIGL 347 >UniRef50_C0Q9H9 HdrA3' n=2 Tax=cellular organisms RepID=C0Q9H9_DESAH Length = 608 Score = 43.5 bits (101), Expect = 0.014, Method: Compositional matrix adjust. Identities = 31/97 (31%), Positives = 40/97 (41%), Gaps = 17/97 (17%) Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 +L D+G DS GL+ S R+N D+C GCG C +C +A Sbjct: 486 FLGDKGLDSQ----GLSQ--------FRESKFAIARVNADRCSGCGNCVAAC---PFEAC 530 Query: 363 EWSEKTRTPHC--NTEKCVGCLLCGHVCPVGCIELGE 397 HC N +C GC C VCP I+L E Sbjct: 531 RLEPGNGRYHCRVNPFRCTGCGTCVAVCPNNSIQLPE 567 >UniRef50_A0LGM4 4Fe-4S ferredoxin, iron-sulfur binding domain protein n=2 Tax=Deltaproteobacteria RepID=A0LGM4_SYNFM Length = 381 Score = 43.5 bits (101), Expect = 0.014, Method: Compositional matrix adjust. Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 14/72 (19%) Query: 335 VYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK-----------TRTPHCNTEKCVGCLL 383 V P++ L C+GCG C C H+A+E ++ T+ + +CVGC Sbjct: 186 VSPQLILKNCIGCGVCRDQC---AHEAIELVDRPEDAPRPEPKITQMARIDPRRCVGCAA 242 Query: 384 CGHVCPVGCIEL 395 C H CP +E+ Sbjct: 243 CIHACPQHALEV 254 >UniRef50_A8TFX4 4Fe-4S ferredoxin iron-sulfur binding domain protein n=1 Tax=Methanococcus voltae A3 RepID=A8TFX4_METVO Length = 419 Score = 43.5 bits (101), Expect = 0.015, Method: Compositional matrix adjust. Identities = 24/60 (40%), Positives = 31/60 (51%), Gaps = 2/60 (3%) Query: 339 INLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEV 398 IN DKC+GC C +C A+ S +T P+ N + CV C LC CPV I+ E Sbjct: 314 INEDKCIGCRICSKAC--NVENAISISSETNMPYINPDYCVRCGLCHRECPVDAIDFPET 371 >UniRef50_C8R1B2 4Fe-4S ferredoxin iron-sulfur binding domain protein n=2 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8R1B2_9DELT Length = 1029 Score = 43.5 bits (101), Expect = 0.015, Method: Compositional matrix adjust. Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 12/85 (14%) Query: 318 LANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWS--EKTRTPHCNT 375 LA I PA + R+ +KC+GCG C C ++A+ EK R T Sbjct: 936 LAKGTITPAP-------IVSRVETEKCIGCGVCETFC---PYKAIRLHKVEKGRKAETVT 985 Query: 376 EKCVGCLLCGHVCPVGCIELGEVKF 400 C GC +C CP I++G F Sbjct: 986 ASCKGCGVCAARCPTLAIDMGRFTF 1010 >UniRef50_A1S155 4Fe-4S ferredoxin, iron-sulfur binding domain protein n=1 Tax=Thermofilum pendens Hrk 5 RepID=A1S155_THEPD Length = 229 Score = 43.5 bits (101), Expect = 0.016, Method: Compositional matrix adjust. Identities = 21/57 (36%), Positives = 30/57 (52%), Gaps = 1/57 (1%) Query: 339 INLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 ++ DKC+GCG C C A++W + R + KC+GC C CPVG + L Sbjct: 158 LDKDKCIGCGACVSVCASIAG-AIKWRKSGRKVEVDAAKCLGCGACVKECPVGALSL 213 >UniRef50_C3X731 Molybdopterin oxidoreductase n=2 Tax=Oxalobacter formigenes RepID=C3X731_OXAFO Length = 701 Score = 43.5 bits (101), Expect = 0.016, Method: Compositional matrix adjust. Identities = 23/64 (35%), Positives = 32/64 (50%), Gaps = 12/64 (18%) Query: 339 INLDKCVGCGRCYISCYDGGHQAMEWSEKT---------RTPHCNTEKCVGCLLCGHVCP 389 + D C+GCG C ++C + G +A++ E TP EKC+GC C VCP Sbjct: 562 LRCDICIGCGLCELACIEVGAEALKMVETKGGRMVFKDFTTP---AEKCIGCGACTSVCP 618 Query: 390 VGCI 393 G I Sbjct: 619 TGAI 622 >UniRef50_C1EEA5 Dihydrouridine synthase n=1 Tax=Micromonas sp. RCC299 RepID=C1EEA5_9CHLO Length = 465 Score = 43.5 bits (101), Expect = 0.016, Method: Compositional matrix adjust. Identities = 35/101 (34%), Positives = 48/101 (47%), Gaps = 9/101 (8%) Query: 103 VLIASIMGENEQQWEELAR-LVQEAGADMIECNFSCPQ--MTSHAMGSDVGQSPELVEKY 159 +L A +MG NE E AR L + GA ++ N CP +T GS + + P VE Sbjct: 133 LLAAQLMGSNEDLLERCARFLAHQGGAPRVDLNCGCPANVVTGKGAGSSLLRDPRDVEAM 192 Query: 160 CRAVKR---GSTLPMLAKMTPNIGD---MCEVALAAKRGGA 194 RAV R G+ + K+ D + E LAA+ GGA Sbjct: 193 TRAVARGVAGTGCAVTVKLRSGFDDRGLLRENLLAAQAGGA 233 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria ... 563 e-159 UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14... 499 e-140 UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Ta... 422 e-116 UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria... 411 e-113 UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydr... 391 e-107 UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 ... 376 e-103 UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 ... 342 1e-92 UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genom... 334 3e-90 UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehyd... 334 4e-90 UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Ta... 329 1e-88 UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 ... 329 1e-88 UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 ... 327 7e-88 UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1... 323 6e-87 UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 ... 320 8e-86 UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 ... 318 3e-85 UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-clust... 315 1e-84 UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10... 313 6e-84 UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 ... 307 4e-82 UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 ... 306 1e-81 UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga ... 303 8e-81 UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerot... 301 4e-80 UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerot... 300 9e-80 UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 ... 298 4e-79 UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 ... 296 7e-79 UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydroge... 295 2e-78 UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax... 295 3e-78 UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 294 4e-78 UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria R... 282 2e-74 UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchae... 279 1e-73 UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit ... 278 3e-73 UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit ... 277 4e-73 UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales... 277 6e-73 UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 273 7e-72 UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9... 268 2e-70 UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasm... 268 3e-70 UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocell... 263 1e-68 UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria ... 263 1e-68 UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotat... 261 2e-68 UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchae... 261 3e-68 UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 ... 261 3e-68 UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 ... 259 1e-67 UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 259 1e-67 UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydoth... 259 2e-67 UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 ... 258 2e-67 UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidal... 258 2e-67 UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomu... 258 4e-67 UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 255 2e-66 UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+]... 255 3e-66 UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 254 3e-66 UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine d... 253 8e-66 UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria R... 253 1e-65 UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria R... 251 3e-65 UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desul... 247 5e-64 UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39... 246 8e-64 UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 ... 246 2e-63 UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10... 245 2e-63 UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14... 244 4e-63 UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular o... 243 7e-63 UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira... 243 1e-62 UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_A... 242 2e-62 UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromat... 240 5e-62 UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured ... 240 6e-62 UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimona... 240 9e-62 UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subuni... 238 4e-61 UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 ... 236 1e-60 UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organ... 236 1e-60 UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 ... 236 1e-60 UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacte... 235 2e-60 UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subuni... 234 3e-60 UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 ... 233 8e-60 UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocys... 233 1e-59 UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteo... 233 1e-59 UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota R... 231 3e-59 UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfuroco... 231 4e-59 UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus te... 231 4e-59 UniRef50_A8RT96 Putative uncharacterized protein n=1 Tax=Clostri... 230 6e-59 UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanoba... 230 7e-59 UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 229 1e-58 UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 229 1e-58 UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria R... 229 2e-58 UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer s... 229 2e-58 UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collins... 229 2e-58 UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 ... 228 2e-58 UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycet... 228 2e-58 UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteri... 228 2e-58 UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular ... 228 3e-58 UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 ... 227 5e-58 UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malasse... 227 5e-58 UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 226 9e-58 UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic... 226 1e-57 UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular ... 226 1e-57 UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12... 226 2e-57 UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae R... 225 2e-57 UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 ... 224 4e-57 UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobac... 224 4e-57 UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 ... 224 4e-57 UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteo... 223 7e-57 UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsia... 223 1e-56 UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibr... 223 1e-56 UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobac... 223 1e-56 UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroi... 222 2e-56 UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family ... 221 3e-56 UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaprote... 221 4e-56 UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglob... 220 7e-56 UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=St... 220 7e-56 UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae... 220 9e-56 UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular o... 220 9e-56 UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 ... 219 2e-55 UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacte... 218 2e-55 UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepI... 218 4e-55 UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 ... 217 5e-55 UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Ric... 217 6e-55 UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphyloco... 217 7e-55 UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 217 7e-55 UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospir... 217 8e-55 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 217 8e-55 UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago ma... 217 8e-55 UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter... 217 8e-55 UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 217 8e-55 UniRef50_C4T7U5 Dihydropyrimidine dehydrogenase n=1 Tax=Yersinia... 216 9e-55 UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collins... 216 1e-54 UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 ... 216 1e-54 UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria R... 216 2e-54 UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacte... 216 2e-54 UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydrooro... 216 2e-54 UniRef50_A7H8H3 Dihydroorotate dehydrogenase n=4 Tax=Anaeromyxob... 215 2e-54 UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria R... 215 2e-54 UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 215 2e-54 UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithioba... 215 3e-54 UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerot... 214 4e-54 UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1... 214 4e-54 UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular o... 214 5e-54 UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacter... 214 7e-54 UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococ... 212 1e-53 UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae... 212 1e-53 UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyru... 211 3e-53 UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae Re... 211 4e-53 UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobac... 210 6e-53 UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirell... 210 8e-53 UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella ... 210 9e-53 UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neoricketts... 209 1e-52 UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidob... 209 1e-52 UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus... 209 1e-52 UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria R... 209 2e-52 UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 209 2e-52 UniRef50_C2MA24 Dihydroorotate dehydrogenase 2 n=1 Tax=Porphyrom... 209 2e-52 UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira ... 208 3e-52 UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=... 208 3e-52 UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, put... 207 5e-52 UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 ... 207 8e-52 UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Cl... 206 1e-51 UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whippl... 205 3e-51 UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebact... 205 3e-51 UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. ... 205 3e-51 UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter... 204 3e-51 UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobact... 204 6e-51 UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=P... 202 1e-50 UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_L... 202 1e-50 UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flav... 202 3e-50 UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/... 199 1e-49 UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistip... 199 2e-49 UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobact... 198 3e-49 UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family prote... 198 4e-49 UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 197 5e-49 UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonprot... 197 5e-49 UniRef50_B3EQ67 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 197 5e-49 UniRef50_B3DVT8 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 196 2e-48 UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=ca... 195 2e-48 UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria R... 194 4e-48 UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 194 6e-48 UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacte... 194 6e-48 UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit ... 194 7e-48 UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 193 8e-48 UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmid... 192 2e-47 UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular or... 192 2e-47 UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 ... 191 4e-47 UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 ... 190 8e-47 UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 190 9e-47 UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce... 189 2e-46 UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria ... 187 5e-46 UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidoba... 187 6e-46 UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaprote... 186 9e-46 UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=ca... 186 1e-45 UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 186 1e-45 UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (c... 186 2e-45 UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobac... 186 2e-45 UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 ... 182 2e-44 UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobaci... 180 7e-44 UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, put... 180 8e-44 UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotoga... 179 1e-43 UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopol... 167 8e-40 UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family prote... 161 4e-38 UniRef50_C0CVL1 Putative uncharacterized protein n=1 Tax=Clostri... 161 5e-38 UniRef50_A1B7Q9 Dihydroorotate oxidase B, catalytic subunit n=1 ... 151 4e-35 UniRef50_UPI00019039D0 dihydropyrimidine dehydrogenase n=2 Tax=R... 143 1e-32 UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyosteli... 138 3e-31 UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 134 6e-30 UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospiril... 129 3e-28 UniRef50_A8L1Y0 Dihydroorotate oxidase n=4 Tax=Frankia RepID=A8L... 128 4e-28 UniRef50_D2S9D7 Dihydroorotate oxidase n=1 Tax=Geodermatophilus ... 128 4e-28 UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacter... 124 5e-27 Sequences not found previously or not previously below threshold: UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhab... 211 3e-53 UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular o... 210 9e-53 UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria Re... 206 2e-51 UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus ce... 205 2e-51 UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromo... 204 4e-51 UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma ... 203 1e-50 UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10... 196 2e-48 UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japoni... 196 2e-48 UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=u... 192 1e-47 UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria R... 192 1e-47 UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular ... 190 9e-47 UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonosp... 189 1e-46 UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia ba... 189 2e-46 UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobacul... 188 3e-46 UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodosp... 187 4e-46 UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 187 5e-46 UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma... 187 8e-46 UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomyce... 186 1e-45 UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 186 2e-45 UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondr... 182 2e-44 UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistip... 182 2e-44 UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia R... 180 8e-44 UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteo... 180 1e-43 UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacter... 177 9e-43 UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella f... 175 3e-42 UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobilunc... 174 4e-42 UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomyce... 174 4e-42 UniRef50_Q7US31 Putative uncharacterized protein n=1 Tax=Rhodopi... 173 1e-41 UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus ... 172 2e-41 UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacte... 166 1e-39 UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes ... 165 2e-39 UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomy... 165 2e-39 UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=... 165 3e-39 UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacte... 162 2e-38 UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellula... 162 3e-38 UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinom... 161 5e-38 UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold... 160 6e-38 UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sede... 160 1e-37 UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=... 159 2e-37 UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaprote... 145 2e-33 UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succi... 142 2e-32 UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroid... 140 7e-32 UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bactero... 137 5e-31 UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 ... 129 2e-28 UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=... 127 5e-28 UniRef50_UPI000187EFAF hypothetical protein MPER_16226 n=1 Tax=M... 122 2e-26 UniRef50_C1SIN0 Putative uncharacterized protein n=1 Tax=Denitro... 122 2e-26 UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 ... 122 3e-26 UniRef50_UPI0001B4E622 dihydroorotate dehydrogenase n=1 Tax=Stre... 121 5e-26 >UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria RepID=YEIA_ECOLI Length = 411 Score = 563 bits (1450), Expect = e-159, Method: Composition-based stats. Identities = 411/411 (100%), Positives = 411/411 (100%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR Sbjct: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA Sbjct: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG Sbjct: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR Sbjct: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL Sbjct: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ Sbjct: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL Sbjct: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 >UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14 Tax=Bacteria RepID=A5VL42_LACRD Length = 432 Score = 499 bits (1286), Expect = e-140, Method: Composition-based stats. Identities = 268/413 (64%), Positives = 325/413 (78%), Gaps = 2/413 (0%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF--FIANEVS 58 M+ KDLS+ F GV F NPFCLSSSPVGNCYEMC AYD GWGG+V+KT+ F +EVS Sbjct: 1 MIKKDLSVDFLGVHFENPFCLSSSPVGNCYEMCKNAYDAGWGGIVYKTLSPTHFKIDEVS 60 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 PRFD L KED F+ FKNMEQ++EHPLE++LA +RRLKE+YP+KVLIASIMGE + W Sbjct: 61 PRFDELAKEDMHFVAFKNMEQLSEHPLEQDLADMRRLKEEYPNKVLIASIMGETLEDWTN 120 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 LA+LV E GADMIE NFSCPQMTSH MGSDVG +PEL +K C AVKRG++LP+LAKMTPN Sbjct: 121 LAKLVTETGADMIELNFSCPQMTSHTMGSDVGTNPELCKKNCEAVKRGTSLPVLAKMTPN 180 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I M V A GGADG +AINTVKSI ++DL +K+G+P ++GKSS+SG SGKAVKPIA Sbjct: 181 ITTMVPVVKACLEGGADGFSAINTVKSIVDVDLKKKVGLPNIDGKSSVSGLSGKAVKPIA 240 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LRF+QQ+R+ L PISGIGGIETWEDAAEF+LLGA TLQVTT IM+YGYRI++D+ + Sbjct: 241 LRFLQQLRSAAGLEQLPISGIGGIETWEDAAEFILLGATTLQVTTAIMEYGYRIIDDLTN 300 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGG 358 GL HY+ +Q D LQ++VGLAN NI+P LDR+Y VYP+I+ DKC+GCGRC+ISC DG Sbjct: 301 GLMHYMEEQHVDHLQDLVGLANKNIIPTNQLDRNYKVYPKIDWDKCIGCGRCFISCQDGA 360 Query: 359 HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 HQA+ W ++ R P + KCVGC LC VCPVG I+LG V+ K G K +P + Sbjct: 361 HQALTWDDEKRQPVFDKSKCVGCQLCALVCPVGAIKLGLVEIKPGHKGNPAEI 413 >UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Tax=Bacteroides cellulosilyticus DSM 14838 RepID=UPI0001968A99 Length = 494 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 207/398 (52%), Positives = 271/398 (68%), Gaps = 3/398 (0%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 +LS+ FCG++ NPF L+SSPV + +EMC A+D GW GV +KTI F+ + EVSPRF Sbjct: 98 TQAELSVNFCGIRCENPFFLASSPVASSFEMCCHAFDAGWAGVSYKTISFYQSREVSPRF 157 Query: 62 DHLV-KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 D L + F GFKN+EQ++ H EEN +RRLKE YP+KV+IASIMG N +W LA Sbjct: 158 DALPGEHPFSFCGFKNLEQLSPHSAEENFEIIRRLKERYPEKVIIASIMGRNCDEWTVLA 217 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 R+ +EAGAD+IECNFSCPQM +GSD+GQ +L+ Y RA ++GS LP++AKMTPNIG Sbjct: 218 RMAEEAGADLIECNFSCPQMAKQGLGSDIGQDQDLIALYTRATRKGSRLPIIAKMTPNIG 277 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 +M A+ A GA+ +AAINTVKSIT I+ P + G+S++ GYSG+AVKPIALR Sbjct: 278 NMELPAMTAIANGANSLAAINTVKSITRINTENFSSYPDIGGQSAVGGYSGQAVKPIALR 337 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 FI+ + ++P L+ P+ GIGGI TW+DA +F+LLG LQV T +M+YGYRI++ + GL Sbjct: 338 FIRDLASYPPLKGIPLFGIGGITTWQDALDFILLGCTALQVCTSVMEYGYRIIDHLKEGL 397 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 S Y+ SL E+ GLA N+V E LDR ++ I+ +C+ CGRCYISC DGGHQ Sbjct: 398 SIYMKQHDIASLDELRGLALPNLVQPEQLDRERKLHCEIDSRRCIHCGRCYISCLDGGHQ 457 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEV 398 A+ W RTP + CVGC LC VCP I L Sbjct: 458 AIGWE--KRTPMIDKSLCVGCGLCTLVCPTEAISLVNS 493 >UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria RepID=A9GKC4_SORC5 Length = 462 Score = 411 bits (1056), Expect = e-113, Method: Composition-based stats. Identities = 182/434 (41%), Positives = 246/434 (56%), Gaps = 35/434 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLSI F G+K PNPF L+S+P N + +A+D GWGG V+KT+G I VS RF Sbjct: 1 MADLSIDFAGIKSPNPFWLASAPPTNTGDQVRRAFDAGWGGAVWKTLGNPIV-NVSSRFG 59 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + +T +G N+E I + PL+ NL +R +K YP LIAS+M E + +W E+ R Sbjct: 60 GIDYGNTRLMGLNNVELITDRPLDVNLKEMREIKRRYPGHALIASLMVETKDEWREIIRK 119 Query: 123 VQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ GAD +E NF CP M MGS VG P ++++ R +T P++ K+TPN+GD Sbjct: 120 AEDTGADGLELNFGCPHGMCERGMGSAVGNEPAVLQEIARWAVEFATTPVIVKLTPNVGD 179 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E A R GA G++ INTVKS+ +DL + + +P V G S+ GY G AVKPIAL Sbjct: 180 ILEPGEAVLRSGAHGVSLINTVKSLMGVDLERMVPLPRVGGASTNGGYCGPAVKPIALHL 239 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q+ HP + PISGIGGI DAAEF+ LGA ++QV T +M YGYRIVE+M GLS Sbjct: 240 LSQLARHPGVGRLPISGIGGISNSRDAAEFIALGATSVQVCTAVMHYGYRIVEEMIEGLS 299 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQA 361 +L D G S+ E+ G A + +LD SY V I+ DKC+GC CY++C DG HQ Sbjct: 300 DWLDDHGMRSVNELRGRAIPQVQEWGELDLSYRVVADISADKCIGCQLCYVACMDGAHQC 359 Query: 362 MEWSEKT--------------------------------RTPHCNTEKCVGCLLCGHVCP 389 + +T R P + E+C+GC LC VCP Sbjct: 360 IHLPGRTEAEARAAGHTHLPKVLPDRAVTADPSGDAAPSRVPFVDEEECIGCNLCALVCP 419 Query: 390 V-GCIELGEVKFKK 402 V GCI + EV K Sbjct: 420 VPGCITMREVPSGK 433 >UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydrouracil dehydrogenase (NAD+) / dihydroorotate oxidase B, catalytic subunit n=94 Tax=Bacteria RepID=Q01P61_SOLUE Length = 446 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 178/437 (40%), Positives = 250/437 (57%), Gaps = 39/437 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS F G++ PNPF L+S P NC E +A+D GWGG V+KTIG VS R+ Sbjct: 1 MADLSTNFAGIRCPNPFWLASGPPTNCGEQIMRAFDAGWGGAVWKTIG-EPIVNVSSRYS 59 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-WEELAR 121 + +G N+E I++ P+E NL + +K+ YP +IAS+M E+ ++ W ++ + Sbjct: 60 SVDWNGQRMMGLNNIELISDRPIETNLREITEVKKRYPKHAVIASLMVESTREAWHDIVK 119 Query: 122 LVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++AGAD +E NF CP M+ MG+ VGQ P+ VK + P+L K+TPNI Sbjct: 120 RSEDAGADGLELNFGCPHGMSERGMGAAVGQVPDYSCMITEWVKEVARTPVLVKLTPNIT 179 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ VA AAKRG AD ++AINT+ SIT IDL+ P V GK+S GY G AVKPIAL Sbjct: 180 DIRAVARAAKRGRADALSAINTINSITGIDLDTFTPRPNVGGKTSHGGYCGPAVKPIALH 239 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 +QQ+ + P + PISGIGGI W +AAEF+LLG T+QV T M YG+RIVEDM GL Sbjct: 240 LVQQIASDPAVG-LPISGIGGIGGWREAAEFILLGCGTVQVCTAAMHYGFRIVEDMIDGL 298 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 S+++ ++GF ++++ GL+ + + LD +Y + RIN DKC+GC CY++C+DG HQ Sbjct: 299 SNWMDEKGFRTIEDFRGLSVPRVTDWKHLDLNYKIVARINRDKCIGCDLCYVACWDGAHQ 358 Query: 361 AMEWSEKT----------------------------------RTPHCNTEKCVGCLLCGH 386 + R P + +CVGC LC Sbjct: 359 CIHLDGHAVPAAVEAASRASIAVTPIAKLDAAQAALGTTPPHRIPRVDEHECVGCNLCWL 418 Query: 387 VCPV-GCIELGEVKFKK 402 VCPV CI + +V+ + Sbjct: 419 VCPVEHCITMEKVETGQ 435 >UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E2T4_GEOLS Length = 398 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 137/399 (34%), Positives = 216/399 (54%), Gaps = 11/399 (2%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + L T+ GV F NPF L+S+P +M +A++ GWGG V KT+ + + RF Sbjct: 1 MPVVLDSTYLGVVFRNPFVLASAPPTATADMVRRAFEAGWGGAVIKTLIREPVHNLPNRF 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG--ENEQQWEEL 119 + + GF+N+E ++E +E A+R +K D+PD +I SIMG + +W L Sbjct: 61 AAIRHGNR-ITGFENLELLSEQAPDEWYRAIRCIKADFPDCPIIGSIMGAANSPDEWHSL 119 Query: 120 ARLVQEAGADMIECNFSCPQM-TSHAMGSDVGQSPELVEKYCRAVK--RGSTLPMLAKMT 176 A Q+AGAD++E NFSCP G+ +GQ+P+ + R V + T+P++ K+T Sbjct: 120 ALGCQDAGADLLELNFSCPHGYPERGRGAAIGQNPDYAAQITRWVTDCKEITIPVIPKLT 179 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 + ++ +A GA G AINT+ S DL P + GK+S GYSG +KP Sbjct: 180 AAVANIQNIAEELALAGAHGFCAINTIPSFFGFDLRTLRPKPDIGGKTSYGGYSGPGIKP 239 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 IALR + ++ P L P+ GGI DA EF+LLGA +Q+ T +M +G+ I++ M Sbjct: 240 IALRAVSELCQSPGL---PVMASGGIANGFDAVEFMLLGAPVVQMATEVMLHGFGIIDRM 296 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYD 356 L ++ F + + +GL ++ + L +V PR+ ++C CG C+ +C D Sbjct: 297 QQELREFMTWHDFTAPVDFIGLCRDSATSFKKLPAGTMVSPRLLAERCTHCGACFTACRD 356 Query: 357 GGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 GG+QA+ W++ P + C C LC HVCP G +++ Sbjct: 357 GGYQAISWNKG--LPGIDPTVCKSCSLCSHVCPAGALQM 393 >UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MJK5_ALKOO Length = 372 Score = 342 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 118/393 (30%), Positives = 191/393 (48%), Gaps = 24/393 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS+ F G+ NP +S+ P+ M KA + G G VV KTI I V PR Sbjct: 1 MDLSVNFLGLSLKNPIIVSAGPLTGSGSMMRKAIEAGAGAVVTKTIANEIRPNVRPRLVK 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 G G N+E + LEE + K V+IA+I+G + +A+ V Sbjct: 61 ------GREGLHNIELYSGFTLEEWENEIAYAK--IHGAVVIANILGHTSSEIAYIAQKV 112 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 ++ GAD +E SCP V P + ++ +AV +P++ K++ N ++ Sbjct: 113 EQFGADAVELGVSCPHGEGL---EGVISEPSKLYEFTKAVVDRIKIPVMVKLSSNTVNVV 169 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 ++A AA++ GA I+ I+TV+SI +D+ + G ++ + GYSG A++PI L I Sbjct: 170 KLARAAEKAGASAISGIDTVRSIAGVDIEK--GRVLLP---TFGGYSGDAIRPIGLAAIA 224 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + + PI GIGGI +E E+++LGA+T+QV T I+ GY + + GL+ + Sbjct: 225 SIA---QATSIPICGIGGITNYEHILEYMMLGASTVQVCTSIILNGYEHISTLLDGLNGW 281 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 +A + + E+ G+A ++ E++ + V + K + C RC SC G + Sbjct: 282 MAQHSYRNFDEIKGMALVSLKSFEEIKQEPYVSQPVGNCKSMQCNRCEKSCIWGAIKVNR 341 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 + + + C GC LC VCP EL Sbjct: 342 EN-----VRVDRKLCTGCGLCVSVCPQRIFELR 369 >UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CDX9_PARTE Length = 997 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 133/426 (31%), Positives = 204/426 (47%), Gaps = 36/426 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKT--IGFFIANEVSPRFD 62 DLSI GV F NPF L+S+P Y M +A+ GWG V KT + VSPR Sbjct: 544 DLSINILGVNFLNPFGLASAPPTTSYPMIKRAFQEGWGFAVVKTFVLDKDAITNVSPRIY 603 Query: 63 HLVKED-TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQ-QWEELA 120 + G+ N+E I+E + L + +K+++P+ VLI SIM ++ + W EL Sbjct: 604 KSTTDPLKQDPGYANIELISEKSAKYWLEGSKAIKKEFPNHVLIGSIMCQHIEQDWRELT 663 Query: 121 RLVQEAG-ADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R + G DM+E N SCP MT MG G++P +V+ C+ V +P++ K+TPN Sbjct: 664 RKCKNEGQFDMLELNLSCPHGMTELGMGRACGENPAIVKDICQWVTSEIDIPVIVKITPN 723 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNID-LNQKIGMPIVNGKSSISGYSGKAVKPI 237 D ++A AAK GGA + NT ++ + D L + G G ++PI Sbjct: 724 YPDSADIAQAAKEGGAKAVTLTNTFPTLMDPDPLGTPWPAVGEENNVTYGGGCGSMLRPI 783 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR-IVEDM 296 ALR ++ + D I G GGI + A FL GA+ Q+ + + + ++ D+ Sbjct: 784 ALRKTSEVAKA--IPDIAIFGSGGIIQGDHALSFLRYGASAFQICSAVQDQDFATVLYDL 841 Query: 297 ASGLSHYLAD---------QG----------------FDSLQEMVGLANNNIVPAEDLDR 331 + +L +G + L+ +VG ++I ++ R Sbjct: 842 KTSFQAHLYASYNLNQKQWKGQFPTSQKQKPSFAFSSNNKLKNLVGSGLHHIKDIAEMKR 901 Query: 332 SYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPV- 390 + P+IN D C+ CGRCY++C D G+QA+++ P E C GC LC VCPV Sbjct: 902 QDFLVPQINEDSCLKCGRCYLTCLDSGYQAIKFDNFNSFPTIIEELCTGCALCHAVCPVE 961 Query: 391 GCIELG 396 G I + Sbjct: 962 GSISME 967 >UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehydrogenase-like protein n=14 Tax=cellular organisms RepID=Q9LVI9_ARATH Length = 426 Score = 334 bits (857), Expect = 4e-90, Method: Composition-based stats. Identities = 140/345 (40%), Positives = 200/345 (57%), Gaps = 12/345 (3%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN--EVSP 59 DLS+T G+K PNPF + S P G Y + +A+D GWG V+ KT+ + V+P Sbjct: 48 SEPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLDASKVINVTP 107 Query: 60 RFDHLVKEDTG-----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NE 113 R+ L G IG++N+E I++ PLE L RLK++YPD++LIAS+M E N+ Sbjct: 108 RYARLRTGSNGSAKTDVIGWQNIELISDRPLETMLKEFERLKKEYPDRILIASVMEEYNK 167 Query: 114 QQWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 WEEL V++ G D +E NFSCP M MG+ VGQ L+++ C + +T+P+ Sbjct: 168 TAWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLDEVCGWINAKATVPVW 227 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 AKMTPNI D+ E A + + G +GIAAINT+ S+ ID+ P V G S+ GYS K Sbjct: 228 AKMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDMKTLRPEPCVEGYSTPGGYSYK 287 Query: 233 AVKPIALR---FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 AV+PIAL I +M D +SGIGG+ET DAAEF+LLG+ T+QV TG+M +G Sbjct: 288 AVRPIALAKVMNIAKMMKSEFSEDRSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMMHG 347 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYI 334 Y V+ + + L ++ F +++E G + DL + Sbjct: 348 YGHVKTLCAELKDFMKQHNFSTIEEFRGHSLQYFTTHTDLVKRQK 392 >UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0EHW2_ENTDI Length = 901 Score = 329 bits (844), Expect = 1e-88, Method: Composition-based stats. Identities = 144/452 (31%), Positives = 225/452 (49%), Gaps = 61/452 (13%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKT--IGFFIANEVSPRFD 62 D+S+T G+K+ NPF +SS+PV Y+ + + G+G + KT + I R Sbjct: 437 DISVTVDGIKYENPFGISSAPVSGTYDHLKRCFQAGFGFALTKTYPLEKDIQKNNHIRIV 496 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-ENEQQWEELAR 121 V + + N+ I+EH L ++++LK ++P+KV+IASIM +N W LA+ Sbjct: 497 K-VYDSQESTSYNNIVMISEHSHHYWLESIKKLKAEFPNKVVIASIMCMDNADDWHLLAK 555 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSD----------------VGQSPELVEKYCRAVKR 165 L +EAGAD +E NFSCP G++ +G SP +E+ R V Sbjct: 556 LSEEAGADALELNFSCPNECHGNDGNEGGCEGGFKSHNAMAMAIGVSPAAIERCTRYVVE 615 Query: 166 GSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 +P+ K+TPN+G++ E+A AA RGGA G++ INTV I+ I L+ + +++ Sbjct: 616 SVHIPVYPKLTPNVGNIEELAAAAMRGGASGVSTINTVFGISEITLSGHPWPQVGVERNT 675 Query: 226 I-SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 I G SG V+PIA+R I Q+ H E + GIGG+ + E A + + GA+ +Q+ + Sbjct: 676 ISGGLSGDLVRPIAIRQIAQVLRHNENVRGHLLGIGGVRSAETAMQLIYTGASVVQMCSS 735 Query: 285 IMQYGYRIVEDMASG------------LSHYLADQGFDS--------------------- 311 + ++ Y IV+++ SG L YL QG +S Sbjct: 736 VQKWSYDIVDEIISGTKFILYCWSRPDLRGYLNSQGVESFMPYGEKTPFWTLDNKQDKPV 795 Query: 312 --LQEMVGLANNNIVPAE--DLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK 367 L E+ G+A +I + + + V I + C+GCG C +SC D A+ + Sbjct: 796 PKLAEVTGIALKHIGERKILEGPEKWRVNAHIKNN-CIGCGSCALSCRDNSTTAI--VKD 852 Query: 368 TRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 + EKC+GC LC VCPV IE +VK Sbjct: 853 GNRYRVDDEKCIGCALCSSVCPVNAIEYVKVK 884 >UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D2W4_DESK1 Length = 407 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 114/422 (27%), Positives = 177/422 (41%), Gaps = 47/422 (11%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSP--- 59 DLS+ G+K NP ++ PV + D G G VV KTI A P Sbjct: 5 MADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPRPSMA 64 Query: 60 --------------------RFDHLVKEDTGFI-GFKNMEQIAEHPLEENLAALRRLKED 98 R + + FI N E ++ P E L L + Sbjct: 65 AVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPLVKS 124 Query: 99 YP---DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPEL 155 Y V IASI G ++ L V++AG IE +G+ Sbjct: 125 YCEEKGAVFIASI-GYTPEELSLLGPKVEKAGVQAIEF-----------STHYIGRDYRP 172 Query: 156 VEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 V + +A++ +P+ K++P ++ E+ ++ G DGI A NT+ +ID+ Sbjct: 173 VIEAAKALRESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVET-- 230 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 G+PIV G SG A+KP+AL + Q+ + +L P+ G+GGI D E+ + G Sbjct: 231 GLPIVGGPYGYGWMSGPALKPLALAVVSQVALNTKL---PVIGVGGISRGVDVIEYFMAG 287 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV 335 A+ +Q+ T + G + + ++ +L G+ S+ ++ GLA + P + R + Sbjct: 288 ASAVQICTAALIEGPQAFARIIREVNEWLDRHGYTSILDVKGLALKYLKP--EPRRVWAQ 345 Query: 336 YPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 P ++ KC+GCG C C +E S R N KC GC LC VCP I Sbjct: 346 PPVVDEKKCIGCGFCEQVCNYDAVH-VEESSGKRVARVNIMKCYGCGLCTSVCPTRAIHF 404 Query: 396 GE 397 E Sbjct: 405 IE 406 >UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 Tax=Staphylothermus marinus F1 RepID=A3DL41_STAMF Length = 406 Score = 327 bits (837), Expect = 7e-88, Method: Composition-based stats. Identities = 107/424 (25%), Positives = 173/424 (40%), Gaps = 48/424 (11%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L + G+K NP ++ PV EM D G G VV KTI A P Sbjct: 1 MVSLEVEIAGLKMKNPLMNAACPVSRDAEMMKALIDNGVGAVVAKTISVRPAIVPRPSMG 60 Query: 63 --------------------HLVKEDTG----FIGFKNMEQIA----EHPLEENLAALRR 94 +V D+G N E + EH E +++ Sbjct: 61 AVDRGIVRSQILKTFGPGNVRIVNADSGNYRFIYALLNAELWSDIPAEHYFEREYPIVKK 120 Query: 95 LKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPE 154 E+ I SI G ++ + L Q+AGA+ IE +G+ Sbjct: 121 YAEE-KGVPFIISI-GYKPEELQLLGPKCQKAGANAIEF-----------STHYIGKDYR 167 Query: 155 LVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQK 214 V + +A++ +P+ AK++P ++ E+ ++ G DGI A NT+ +ID+ Sbjct: 168 PVVEAAKALREVVDIPIFAKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDIET- 226 Query: 215 IGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLL 274 G+PIV G + SG A+KP+ + + + P+ G+GGI D E+ + Sbjct: 227 -GLPIVGGPNGYGWMSGPALKPL---ALAVVAEAAKNTHLPVIGVGGISKGTDVIEYFMA 282 Query: 275 GAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYI 334 GA+ +Q+ T + G + + + +L G+DS+ ++ G A + P + R + Sbjct: 283 GASAVQICTAALIEGLGVFRRIEKEIESWLKRHGYDSILDVKGKALKYLKP--EPRRVWA 340 Query: 335 VYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIE 394 P ++ KC+GCG C C + + E R N + C GC LC VCP I Sbjct: 341 KPPVVDPKKCIGCGFCEQVCDYNAVKVVPNEEGKRIAQVNYDLCYGCGLCTSVCPTRAIH 400 Query: 395 LGEV 398 E Sbjct: 401 FEEE 404 >UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1EGR6_9CHLO Length = 434 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 144/338 (42%), Positives = 204/338 (60%), Gaps = 9/338 (2%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI--ANEVSPRF 61 DLS+T G+KFPNPF + S P G Y + KA+D GWGGV+ KT+ V+PR+ Sbjct: 62 PDLSVTVNGLKFPNPFVIGSGPPGTNYTVMKKAFDEGWGGVIAKTVSLNADLVKNVTPRY 121 Query: 62 DHLVKEDTG-FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-WEEL 119 + ED +G++N+E I++ E LA ++LKE+YPD++LIASIM E +++ W E+ Sbjct: 122 AKMKSEDGAEVLGWQNIELISDRSFEVMLAEFKQLKEEYPDRILIASIMDEYKKENWVEV 181 Query: 120 ARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R +E G D E NFSCP M MG+ +GQ ++++ C VK +T+P+ AKMTPN Sbjct: 182 VRRCEEVGVDAFEINFSCPHGMPERKMGAAMGQDCTVLDEVCGWVKEVATVPVWAKMTPN 241 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I D+ E A G DGIAAINT+ SI ++L+ P V G S+ GYS KAV+PIA Sbjct: 242 ITDITEPANVCLEKGMDGIAAINTIMSIMGVNLDTLAPEPCVEGHSTPGGYSYKAVRPIA 301 Query: 239 LR---FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 L I QM E D +SGIGGI+T AAEF+LLG+ T+QV TG+M +GY +V++ Sbjct: 302 LAKCMAIAQM-IKKEFPDRTLSGIGGIDTGGHAAEFILLGSDTVQVCTGVMIHGYPLVQN 360 Query: 296 MASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSY 333 + + L ++ GF+S+ E G++ DL Sbjct: 361 LCAELQEFMGKHGFESIAEFKGMSLEYFTTHTDLVARQ 398 >UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2ELU8_TRIVA Length = 811 Score = 320 bits (819), Expect = 8e-86, Method: Composition-based stats. Identities = 141/454 (31%), Positives = 217/454 (47%), Gaps = 56/454 (12%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L FCG+KF NP +SS+PV YE + G G V KTI + + Sbjct: 361 HVSLETEFCGMKFKNPSGISSAPVSGTYECIRNCFKAGMGWAVTKTI-LPTKDVIRENDF 419 Query: 63 HLVKEDTG---FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM-GENEQQWEE 118 +VK D F N+ + EH E L +++LK ++PD+VL+ASI +++++W+ Sbjct: 420 RIVKADENPGPSGSFCNICMMTEHTEEYWLDTIKKLKAEFPDRVLVASIATSDSKERWQN 479 Query: 119 LARLVQEAGADMIECNFSCPQM------------TSHAMGSDVGQSPELVEKYCRAVKRG 166 L + V AGAD +E N SCP T + +G +G P V++ + VK Sbjct: 480 LVKNVIAAGADALELNLSCPNEVHGEGGCKGGFDTENKIGMALGTHPISVKRISQYVKEA 539 Query: 167 STLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 +T+P K+TPNI D ++A AA GGADG+A INTV I +P V + + Sbjct: 540 TTVPFFVKLTPNITDPIDIAQAALEGGADGVAMINTVSGIAKF-WPDGTPLPQVGKEKYV 598 Query: 227 --SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG V+PIALR I ++ H + + PI GIGGI + A + L G++ Q+ + Sbjct: 599 LSGGLSGDQVRPIALRQISRV--HNKFPEMPILGIGGIGSGYTALQHLYAGSSVFQMCSA 656 Query: 285 IMQYGYRIVEDMASGLSHYL--------------------------------ADQGFDSL 312 I +Y Y IV ++ +GL YL D+ +L Sbjct: 657 IQRYSYDIVREVNAGLQFYLYSWSRPDLRAKLSHYTEMKTLPIQVPIPEDTKQDRKIPTL 716 Query: 313 QEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPH 372 E+ GL +V E D ++ ++ I+ C+ CG+C +SC D +A+ + Sbjct: 717 AELRGLGAKRVVQRESFDINWTLHAEIDDATCLQCGKCALSCRDNSVEAIHLVDGKW--K 774 Query: 373 CNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKE 406 N ++C+GC LC VCPV + + E + +K Sbjct: 775 VNHDECIGCALCHSVCPVQAMHMVESEKRKNWHH 808 >UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q23YG3_TETTH Length = 1080 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 123/435 (28%), Positives = 198/435 (45%), Gaps = 41/435 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKT--IGFFIANEVSPRFD 62 D+S CGVK NPF L+S+P Y M A+++D G+ V KT + VSPR Sbjct: 621 DISTEICGVKMENPFGLASAPPTTSYPMIARSFDIGYDFAVVKTAVLDKDTVFNVSPRIF 680 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-ENEQQWEELAR 121 + + N+E ++E L+ + +++K+DYP+KVLI S+M N+Q W ++ Sbjct: 681 KVPDPLRQECSYGNIELVSEKSLKYWVEGAKQIKKDYPNKVLIGSLMAAYNQQDWIDIMH 740 Query: 122 LVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 V++A DMIE N SCP M MG G+ P++V V + +P++ K+TPN G Sbjct: 741 QVKDAPFDMIELNLSCPHGMNEKGMGRACGEDPDIVRDITSWVTSQTKIPIIVKITPNYG 800 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS-SISGYSGKAVKPIAL 239 +A AA GGA + NT+ + + + + + K+ + G +G ++P A+ Sbjct: 801 QAEILAKAAYEGGAKAVTLTNTMPGLVDPYPDGESFNGVGVEKNVAPGGSTGSILRPFAM 860 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV------ 293 R + + + I GGI + + +L GA LQ+ + + V Sbjct: 861 RKCVDVAKF--VPEIDIFASGGIISGDHGINYLHYGAKALQICSAVQNLDAATVFYDLKT 918 Query: 294 ---EDMASGLSHYLADQG------------------------FDSLQEMVGLANNNIVPA 326 +M + S L G + E+VG + P Sbjct: 919 SLQANMYANSSQKLKKNGWKGQYPPYQFEKLKTPTSVETPQKVPKILEIVGAKLAKVSPI 978 Query: 327 EDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGH 386 E + + I P I+ D C+ CGRCY++C D G+QA+++ P E C GC +C Sbjct: 979 EKMSKEIIQVPEISKDSCLECGRCYVACSDSGYQAIQFDGYNNVPRIIEEDCTGCAICVA 1038 Query: 387 VCPV-GCIELGEVKF 400 CPV I++ K Sbjct: 1039 SCPVENAIKMVPRKL 1053 >UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-cluster domain n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E020_METI4 Length = 387 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 139/361 (38%), Positives = 212/361 (58%), Gaps = 13/361 (3%) Query: 56 EVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQ 114 VS R+ K D +G N+E I++ PL NL ++ +K +P++ LI S+M E + + Sbjct: 3 NVSNRYAVYKKGDR-ILGMNNLELISDRPLSVNLKEIQEVKRLWPNRALIVSMMEEYDRK 61 Query: 115 QWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 +WEELA+ ++ +GAD IE NF CP M GS +GQ P + V+R ++LP++ Sbjct: 62 KWEELAQKIEGSGADGIELNFGCPHGMPERGTGSKIGQDPARCAEVTSWVRRVTSLPLIV 121 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K+TPN+ D+ +A AA GGA ++ INT++SI +D++ +P + GKSS SGYSG+A Sbjct: 122 KLTPNVTDISCIARAAIAGGASALSLINTLESILGVDIDTFEVLPSIAGKSSHSGYSGEA 181 Query: 234 VKPIALRFIQQMRT--HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 +KPIAL ++ + + + IS +GGI +W D EFLLLGA +LQ+ T +M G+R Sbjct: 182 IKPIALNLTAKVASMEEVQKKGLAISAMGGISSWRDGVEFLLLGATSLQLCTSVMLKGFR 241 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCY 351 I ED+ SGL +++ +GF S+ E G + +++VP LD + +IN KC+ C CY Sbjct: 242 IAEDLLSGLKNWMRSKGFRSIAEFRGKSLSHLVPFSKLDPLFKEVAKINPQKCIRCLLCY 301 Query: 352 ISCYDGGHQAMEWSEK-------TRTPHCNTEKCVGCLLCGHVCPV-GCIELGEVKFKKG 403 + C D +Q +E K PH CVGC LC H+CPV CIE+ + ++ Sbjct: 302 VGCRDSAYQCIEVDNKLDLFSNPVNYPHVREADCVGCSLCRHLCPVDSCIEMIPAQAEEN 361 Query: 404 E 404 Sbjct: 362 R 362 >UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10 Tax=Bacteria RepID=A9BIU8_PETMO Length = 363 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 104/393 (26%), Positives = 178/393 (45%), Gaps = 32/393 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 D+S+ G+ P ++ P E KA + G G +V KT+ A P Sbjct: 1 MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMA 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + GF N E +E LE+ + + V+I +G + +E+ Sbjct: 61 QVKG------GFINTELWSELSLEQWIEKEYPQVVETGLPVIIG--VGYTSEDIKEVIPK 112 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 V+ AD E +G P + RA K + LP++ K++P + D+ Sbjct: 113 VERF-ADAFEL-----------STHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQV-DI 159 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + A A+ GADG+ IN+ +IDL G P++ ++ SG+A+ P+ALR + Sbjct: 160 PKFAKEAENAGADGLVLINSFGPTLDIDLE--SGKPLLGSENGFGWLSGQAIFPLALRSV 217 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + P+ G+GGI T ++A + ++ GA +QV T + G +I + + + + Sbjct: 218 FE---AVRSVNIPVVGVGGINTGKEAIKMIMAGAQAVQVCTAAILNGPQIYKKITNEIEK 274 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 YL D F SL+E+ G+A NIV + + +++P +N +KC C C SC + A+ Sbjct: 275 YLDDHDFKSLEEIRGIAQKNIVNEANYN---LIFPAVNDEKCTECALCVKSC---VYDAI 328 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 ++ + +T KC GC LC C + L Sbjct: 329 HLIKELHSVRIDTNKCAGCGLCVTRCNFNALSL 361 >UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHS6_KOSOT Length = 361 Score = 307 bits (787), Expect = 4e-82, Method: Composition-based stats. Identities = 103/390 (26%), Positives = 167/390 (42%), Gaps = 34/390 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL+ G++ NP +S P+ + D G G +V KTI A P Sbjct: 1 MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCIIA 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 +I N E E+P E+ + LI S+ G + E L + Sbjct: 61 ----GKNYI--MNTELWTEYPPEKWKGEFIPKFREKSSLPLIVSL-GYTVEDLEVLVPMF 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + AD E V PEL++ R VK+ + P+ K P++ + Sbjct: 114 DDL-ADAFEL-----------STHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEPE 161 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +A A + G DGI AIN++ L +++ + SG +KPIAL ++ Sbjct: 162 VMAKAVEEAGGDGIVAINSLG--PGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVK 219 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ + + PI G+GGI + +D +F++ GA+ +Q+ +G + YG I + + + L Sbjct: 220 RVASSC---NLPIIGVGGISSADDVIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKK 276 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 L G++S+ E+ GLA N+ R+ P+I+ KCV CG C C + A+ Sbjct: 277 LEALGYNSINEIKGLATNSNPEVSYEKRT----PKIDHSKCVKCGVCVEVCP---YFALS 329 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCI 393 E+ + E C GC LC CP I Sbjct: 330 MEEQVI---VDEEACFGCGLCQTKCPTKAI 356 >UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 Tax=Thermosipho RepID=A6LJ97_THEM4 Length = 360 Score = 306 bits (783), Expect = 1e-81, Method: Composition-based stats. Identities = 111/393 (28%), Positives = 174/393 (44%), Gaps = 34/393 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS G+K NP +S P+ YE TG G +V KTI AN P Sbjct: 1 MDLSTEISGIKIENPLMPASGPLVGDYEKIKFIDSTGVGAIVTKTISTKAANVPRP---- 56 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 + + F+ N E +E P E + + ++ K LI S+ G + E L + Sbjct: 57 CIYGENNFV--MNAELWSELPPETWIKEILPKLKNELKKPLIVSV-GYTIEDMEILIPQL 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 E AD E ++H +G D + +A+++ + P+ K++P+I D Sbjct: 114 NEY-ADAFEI-------STHYVGKDYN----TIANIVKAIRKNTNKPIFMKLSPHIPDPV 161 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E GA+GI AIN+ ID+ + ++ + SG +KPIAL ++ Sbjct: 162 EFTKTILENGANGIVAINSWGPTMKIDIKNR--KTLIGNEKGQVWLSGPVIKPIALSIVK 219 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 +R D I G+GGI++ ED EFLL GA +Q+ + + +G I E + + L Sbjct: 220 TIRDA--FPDITIIGVGGIKSAEDVIEFLLSGADAVQLLSSALIFGKDIYEKILNQLPST 277 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 L F+S+ E++ N + YP++N +KC CG C C + A++ Sbjct: 278 LEKYEFNSINEVL-----NTELTVGTVKYTPNYPKVNHEKCTLCGICEKVCP---YFAIK 329 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 +K NT KC GC LC CP I++ Sbjct: 330 IDKKV---KINTYKCFGCGLCESRCPTKSIKIK 359 >UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga lettingae TMO RepID=A8F8E8_THELT Length = 386 Score = 303 bits (776), Expect = 8e-81, Method: Composition-based stats. Identities = 97/404 (24%), Positives = 178/404 (44%), Gaps = 25/404 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF-D 62 DLS + G+K NP ++SS + + KA + G VV K++ +SP Sbjct: 1 MDLSCEYVGIKLKNPIIVASSGLAENLKNMKKAEEHGAACVVAKSLFEEKICRISPTPRF 60 Query: 63 HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 +++ G + F + EQ + E +R+ +I SI ++ W + Sbjct: 61 EIIERKMGKLRSQTFYSFEQASPFDAHEYFEEIRKAVNTLSI-PVIPSINCVTDEGWSQY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 AR+ + AGA +E N SCP + G DV E + + V+ +P++ K+ + Sbjct: 120 ARMAEGAGAPALELNVSCPHGSISFRGGDVE---EKILSVAKIVRDSVKIPLIVKLPMQL 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 +A +R G DG+ N + T +D+N + P+++ +G+ G L Sbjct: 177 SSPLSMAKMLERSGIDGVVMFNRL---TGLDINLEKERPVLHE--GYAGHGGPWAFNYVL 231 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I H + ++ GG+ + ED +++ GA ++V + I GY ++ + Sbjct: 232 RWIAASSPHL---NISVAASGGVGSGEDIIKYIYAGANAVEVCSLIYLSGYEAIDMLLEQ 288 Query: 300 LSHYLADQGFDSLQEMVGLAN-NNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISC-YDG 357 + ++ + + ++ G + I+ E +DR ++ +IN C CG C C YD Sbjct: 289 IKAFMERKSYPDFSQIKGKLSGKAILSNEQIDRRHLFKAQINQALCTSCGTCQKVCIYDA 348 Query: 358 GHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFK 401 +Q + + +E C GC LC +CPV IE+ + K Sbjct: 349 PYQ-------SEKSYVISELCDGCGLCVKLCPVKAIEMVKWSEK 385 >UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0P959_9FIRM Length = 371 Score = 301 bits (770), Expect = 4e-80, Method: Composition-based stats. Identities = 96/390 (24%), Positives = 168/390 (43%), Gaps = 24/390 (6%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKE 67 I+F G+ NP +++ P K D G V+ +TI SPR + E Sbjct: 5 ISFMGLALKNPLIVAAGPWSGGAAAIQKCIDAGAAAVITETIVMEEPWLFSPRIYYHDDE 64 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 N+ + LEE + R+++D LI SI + + +A+ + G Sbjct: 65 ------LLNLSLYGKRTLEEWEGEVERVRKDSCH--LICSIRASSPSEIAYIAQRTERLG 116 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 AD ++ + P +M D+ PE + ++ A ++P++ ++ N+ Sbjct: 117 ADALQLDLYAPM---DSMIEDIHLQPEKLYEFVHAAASAVSIPVMTRLPYNLAASAPHLH 173 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 A +R G I AI ++++++ +DL + + + GY+G+ ++PI+L + Sbjct: 174 AVERAGLRAICAIESLRALSGVDLETQTTL-----MPTYGGYTGRHIRPISLAATATLA- 227 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 +L D PI G+GG+E + EF++LGAA Q+ + IM +GY ++ L ++ Sbjct: 228 --QLTDLPICGVGGVEDYRSILEFIMLGAAAAQLGSAIMLHGYDLITKTVRALEDWMQAH 285 Query: 308 GFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK 367 G+D + G A +++ P E V GCG C C G + Sbjct: 286 GYDDYSSITGAALSSLTPFEKAVHRRAVCRMTQPCSRTGCGLCTCGCMYGA-----LVME 340 Query: 368 TRTPHCNTEKCVGCLLCGHVCPVGCIELGE 397 H N+ +C GC LC CP G L Sbjct: 341 PDGVHLNSSQCTGCGLCVQRCPQGLFHLET 370 >UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PGY1_9FIRM Length = 371 Score = 300 bits (767), Expect = 9e-80, Method: Composition-based stats. Identities = 108/392 (27%), Positives = 175/392 (44%), Gaps = 24/392 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 LS+ F G+ NP +++ P K+ D G VV +TI + V PR Sbjct: 1 MSLSVQFLGMTLKNPVIVAAGPWSCDAAAIQKSIDAGAAAVVTETITLEASTRVCPRLYQ 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 N + LE+ ++R+ D D +LI S+ G E + +A+ V Sbjct: 61 HGGS------LFNTMLYSTIDLEQWEQEIKRI--DKRDSILICSVWGATESETAYIAKKV 112 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + GAD IE + S P + G+S E + Y RAV LP++ K++ + Sbjct: 113 ERLGADAIELSISAP---IGTRSTRFGRSQEQIGGYVRAVVEAVDLPVMVKLSYDASANV 169 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 A ++ GA I+AI+++K + +D+ GMP++ + GYSG ++P+AL Sbjct: 170 AFVHAVEQAGAQAISAIDSLKGLAGVDIEH--GMPLMP---TCGGYSGANLRPVALATTA 224 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + +L I GIGGIE++E E+++LGA +Q+ + ++ GY + + S L + Sbjct: 225 TLA---QLTRCEICGIGGIESYEHVLEYVMLGANAVQLASTVLLAGYERITRIVSDLRAW 281 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 +L G A ++P ED+ +V N + CG C SC GG + Sbjct: 282 TDAHN-TTLAAQHGRALQKLIPFEDIPAQQLVCAFQNPCTRIDCGLCAASCLGGGIRLSS 340 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 T + + C GC LC CP I L Sbjct: 341 DGFYT----VDPDACTGCGLCAARCPEHRIRL 368 >UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 Tax=Clostridiales RepID=C4IB41_CLOBU Length = 362 Score = 298 bits (762), Expect = 4e-79, Method: Composition-based stats. Identities = 105/391 (26%), Positives = 177/391 (45%), Gaps = 34/391 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ T +K NP +S P+ + + + G G +V KTI A V P Sbjct: 1 MNLNTTIGKIKLENPLMPASGPLVGDKDKMSALNEFGVGAMVTKTISSKKAEVVRP---- 56 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + FI N E +E+ E + L +K++ DK LI S+ G ++ E L Sbjct: 57 CIYGGKNFI--MNAELWSEYAPEVWIDEFLPSIKKELKDKPLIISV-GYTKEDMEFLIPK 113 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + + AD E ++H +G D+ +++ + ++R + P+ KM+P+I D Sbjct: 114 L-DVFADAFEI-------STHYVGKDLSN----IKETLKTIRRFTQKPVFMKMSPHIPDP 161 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 A GI AIN++ NID++++ ++ K SG A+KP+AL I Sbjct: 162 IGFAKMVIENKGSGIVAINSLGPTMNIDIDKRSV--LIGNKEGEVWTSGPAIKPMALALI 219 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 +++ + + I G+GGI + +D EFLL GA+ +Q+ + M G + E + L Sbjct: 220 HKIKKA--VPECEIIGVGGISSADDIIEFLLAGASAVQMLSAAMLKGKDLYEKLIEELPK 277 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 L GF+S++E++ + + YP IN DKC C C +C ++ Sbjct: 278 ALKKHGFNSVEEVINE-----KLSIGQVKYEPEYPLINKDKCTNCRLCEKACPYFAITSI 332 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCPVGCI 393 + K +T+ C GC LC CP I Sbjct: 333 DNQIK-----IDTKNCFGCGLCESRCPSKAI 358 >UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium carboxidivorans P7 RepID=C6Q0J2_9CLOT Length = 360 Score = 296 bits (759), Expect = 7e-79, Method: Composition-based stats. Identities = 100/393 (25%), Positives = 177/393 (45%), Gaps = 33/393 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 +L++ G+K NP +S P + + G G +V KTI P Sbjct: 1 MANLNVDLHGIKIKNPIMPASGPQVRNADCMLECVKQGVGALVTKTISEKFVRTARPCMQ 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 F N E +E +E+ + + Y I S+ G ++ E++ + Sbjct: 61 ETKDG-----AFLNSELWSELSVEQWVEKGYSKCKSY-GVPFIVSL-GYTAKEIEKVLPI 113 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + AD+IE ++H M D+ + ++ + S P+ K++P I + Sbjct: 114 ITPY-ADIIEI-------STHYMEKDLESVVDSLK-----IASKSDKPVYIKISPGITKI 160 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 GA G AIN++ +ID+ G+P + G+ SGK++ PIALR++ Sbjct: 161 GWYVKRLVEEGAAGFVAINSLGPCLHIDVET--GLPYLGGEKGYGWLSGKSLNPIALRYV 218 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + P+ G+GGI + EDA ++ GA+ +Q+ T + G + +++ L+ Sbjct: 219 YSIANSVK---VPVIGVGGISSGEDAVAMIMAGASAVQICTAAILEGNGVYSRVSNELNS 275 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 +L GF+S++++ GL + + + ++P+IN +KC CG+C SC + A+ Sbjct: 276 WLDAHGFESVEDIRGLTARKMQERKVIRE--PIFPKINKEKCNSCGKCVKSC---AYSAI 330 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 S+K NT KC GC LC CP IE+ Sbjct: 331 TISDKAN---INTTKCFGCGLCLTRCPETAIEV 360 >UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydrogenase n=1 Tax=Sulfolobus tokodaii RepID=Q972L2_SULTO Length = 350 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 124/348 (35%), Positives = 190/348 (54%), Gaps = 8/348 (2%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS+TF G+ FPNPF + S P A GWGGVV KTIG I + Sbjct: 3 DLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMYAT 62 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDK-VLIASIMG-ENEQQWEELARL 122 ++ + I F+N+E I E PLE LR +K + +I SIMG + +W LAR Sbjct: 63 IRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLARW 122 Query: 123 VQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ GADM+E NF CP G+ +GQ +LV++Y + V +P++AK+TPNI D Sbjct: 123 AEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEYTKEVVSSVGIPVIAKLTPNITD 182 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E A AA+ GA + AINTV + +D+ + +P +NG S G SG AVKPI L Sbjct: 183 IRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGLAA 242 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + ++ T L+ ISG+GGI W DA E++++GA T+Q T + G+ + + L Sbjct: 243 VSKIYTSTSLQ---ISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKELE 299 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGR 349 ++ +G+ ++++M GLA + E L++ + R ++D+ + R Sbjct: 300 SFMERKGYRAIEDMRGLAAKKMTTYEVLEK--VTKRRTSVDEEINTVR 345 >UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax=Eukaryota RepID=DPYD_HUMAN Length = 1025 Score = 295 bits (754), Expect = 3e-78, Method: Composition-based stats. Identities = 115/335 (34%), Positives = 172/335 (51%), Gaps = 11/335 (3%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF--IANEVSPRFD 62 D+S+ G+KF NPF L+S+ M +A++ GWG + KT I VSPR Sbjct: 532 DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRII 591 Query: 63 HL----VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-ENEQQWE 117 G F N+E I+E ++ LK D+PD ++IASIM N+ W Sbjct: 592 RGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWT 651 Query: 118 ELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 ELA+ +++GAD +E N SCP M MG GQ PELV CR V++ +P AK+T Sbjct: 652 ELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLT 711 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLN-QKIGMPIVNGKSSISGYSGKAVK 235 PN+ D+ +A AAK GGA+G+ A NTV + + + + +++ G SG A++ Sbjct: 712 PNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIR 771 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 PIALR + + L FPI GGI++ E +FL GA+ LQV + I + ++ED Sbjct: 772 PIALRAVTSIARA--LPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIED 829 Query: 296 MASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 +GL L + + LQ+ G + + + Sbjct: 830 YCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKP 864 >UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B8E1W3_DICTD Length = 390 Score = 294 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 103/407 (25%), Positives = 183/407 (44%), Gaps = 23/407 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF-D 62 DLS ++ G++ NP ++SS + + K + G G +V K++ VSP Sbjct: 1 MDLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSLFEEEICRVSPTPRF 60 Query: 63 HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 ++ G + F + EQ + EE + + +I SI + W + Sbjct: 61 EIISRSMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLSI-PVIPSINCITDDGWLKY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 +++ +E GA +E N SCP + G DV E + R V+ +P++ K+ + Sbjct: 120 SKMAEEVGAPALELNVSCPHASISFRGQDV---DETILHVARIVRENVKIPIVVKLPMQL 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 VA A + G DG+ N + T +D+N PI++G +G+ G L Sbjct: 177 SSPLAVAKALENIGVDGVVMFNRL---TGLDINLDTEKPILHG--GYAGHGGPWAFNYVL 231 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I R H +L I+G GG+ + +D A+++L GA +Q+ + + GY I+ + G Sbjct: 232 RWISTSRPHLKLS---IAGSGGVGSGDDVAKYILTGADVVQICSIVYLMGYEIIPRIIDG 288 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAE-DLDRSYIVYPRINLDKCVGCGRCYISCYDGG 358 L ++ ++ + +L + G + ++ ++DR ++ IN D C CG C C Sbjct: 289 LKKFMENKKYSTLSDFRGKVSGKVILGNYEIDRRHLYEAYINSDLCTSCGICKKVCIYDA 348 Query: 359 HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEK 405 +E K + T+ C GC LC +CP I + V ++ K Sbjct: 349 --PIEKDGK----YFITDLCDGCGLCVRLCPTKAISMVFVGGRENAK 389 >UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria RepID=PYRD_HELMI Length = 309 Score = 282 bits (722), Expect = 2e-74, Method: Composition-based stats. Identities = 89/326 (27%), Positives = 146/326 (44%), Gaps = 20/326 (6%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 M + +L + G+ NP +S G E + G +V K +P Sbjct: 1 MGSLNLQVNLGGLTMKNPVTTASGTFGFGLEFAPFIDLSRLGAIVVKGTTLEPREGNPTP 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R IG +N E + + L LR++ D +I ++ G + + + L Sbjct: 61 RMAETPAGMLNAIGLQNPG--VEAFIRDYLPPLRQI-----DTPVIVNVSGNSVEDYGRL 113 Query: 120 ARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A ++ EA G +E N SCP + G G P RAV+ + P++ K++PN Sbjct: 114 ASILDEADGVAALEVNISCPNVKEG--GIQFGTLPASAAAVTRAVRENTQKPVIVKLSPN 171 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ E+A A GAD +A INT+ + D++ P++ + G SG A+KP+A Sbjct: 172 VTDITEMARAVVDAGADALALINTLLGM---DIDICTRRPVL--ANIFGGLSGPAIKPVA 226 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR I Q+ PI G+GGI +DA F+L GA + V T R D+ Sbjct: 227 LRMIYQVYRAVH---VPILGMGGIMNSQDAIAFMLAGATAIAVGTANFTN-PRATMDILE 282 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIV 324 G+ Y +G + E++G A++++ Sbjct: 283 GIEEYCCREGVRDVNELIGAAHSHLT 308 >UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchaeota RepID=PYRD_METTH Length = 303 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 100/316 (31%), Positives = 156/316 (49%), Gaps = 17/316 (5%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L + C ++ NP L++ +G+ + Y G G VV K+ R V Sbjct: 5 LETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRP--NPGYRNPTTV 62 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 + G I + E L + + LIAS+ G + +++ A V+E Sbjct: 63 EVTGGVINAIGLSNPGVEAFREELKLVDE------EVPLIASVYGASPEEFASAAASVEE 116 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 ADMIE N SCP + G+ +GQ PEL + AVK +P+ K+TPN+ D+ E+ Sbjct: 117 Y-ADMIELNVSCPHAMA-GCGASIGQDPELTFRVVSAVKDAVDVPISTKLTPNVTDIVEI 174 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A +A+ G+D + IN++ ID+ K PI++ G SG A+KP+A+R + + Sbjct: 175 AGSAEEAGSDALTLINSLGPGMKIDI--KTARPILSNA--FGGMSGPAIKPVAVRCVYDV 230 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 D PI G+GG+ ++DA EFL GA +QV T IM G + + GL ++ Sbjct: 231 YRSV---DIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGLEAFMM 287 Query: 306 DQGFDSLQEMVGLANN 321 +GF S+ EMVGLA++ Sbjct: 288 AEGFSSVDEMVGLAHD 303 >UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit n=5 Tax=Clostridium difficile RepID=C9XJU2_CLODC Length = 361 Score = 278 bits (711), Expect = 3e-73, Method: Composition-based stats. Identities = 96/386 (24%), Positives = 169/386 (43%), Gaps = 39/386 (10%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 F G + +P + S P+ C D G G VV KTI A +P H+V+ Sbjct: 3 NFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIRKERAINPAP---HMVRNT 59 Query: 69 TGFIGFKNMEQIAEHPLEENLA-ALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 N E+ + E+ + + ++K D V IAS+ G ++ EL V AG Sbjct: 60 ANA--LLNNEKWTDFEPEQWIDFEIPQMKRD--GTVCIASV-GHTIEESSELVEKVANAG 114 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 AD IE V + + K +P++ K+ P I ++ + A Sbjct: 115 ADFIEL---------------VSYDYRDLIPMLKDAKERVNIPVIVKLPPMIDEIGDFAK 159 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 + GAD I A ++V ID+ G P++ G + I SG+ +KPI L+ I +++ Sbjct: 160 KLEEAGADAITACDSVGPAFRIDIET--GQPLLGG-NGIGYLSGETIKPITLQRIYEIKK 216 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 + PI G+GG + +DA E ++ GA + + + ++ G +++ + L L Sbjct: 217 QV---NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRL 273 Query: 308 GFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK 367 G+++++ G+ +N++ D++ + +KC C C C +QA + ++K Sbjct: 274 GYNTIENACGIVHNHM---GDVNERLSFEFTYDEEKCTKCKMCERVC---AYQARKLNDK 327 Query: 368 TRTPHCNTEKCVGCLLCGHVCPVGCI 393 N E+C C LC VC + Sbjct: 328 M---ELNEEECRYCGLCISVCKPKAL 350 >UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (Dhodehase) (Dhodase) (Dhod) n=3 Tax=Hydrogenothermaceae RepID=C0QU30_PERMH Length = 320 Score = 277 bits (709), Expect = 4e-73, Method: Composition-based stats. Identities = 95/323 (29%), Positives = 163/323 (50%), Gaps = 19/323 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYD-TGWGGVVFKTIGFFIANEVSPR 60 L LS G+KF NP +S E+ YD + G VV K + + P+ Sbjct: 8 LKDPLSYELFGIKFKNPVWTASGCFSYGLEVAQNLYDISELGAVVVKGLSYRPREGNPPQ 67 Query: 61 FDHLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 +V+ G + ++ E+ ++ L LR D V++A++ GE+E ++ ++ Sbjct: 68 --RIVETPCGMLNSIGLQNPGVEYFIKNILPQLREY-----DTVIVANVFGEDEDEYLKV 120 Query: 120 ARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A ++ +A G D++E N SCP + G G PE + +K+ P+L K++PN Sbjct: 121 AEVLNKADGVDLLELNVSCPNVKKG--GIAFGSDPETLFNLVYRLKQVMEKPLLVKLSPN 178 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I D+ + A A+ GADG+ INT+ + ID++++ PI+ ++ G SG A+ P+A Sbjct: 179 ITDILDTATASVEAGADGLVLINTLLGMA-IDIDKE--EPIIGMRT--GGLSGPAILPVA 233 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +R I Q+ PI G+GGI T +DA + +L GA ++Q+ T Y + + Sbjct: 234 VRMIYQVYEKYG-SSVPIIGVGGITTAQDALQHILAGAVSVQIGTANFYDPYSPL-KVIK 291 Query: 299 GLSHYLADQGFDSLQEMVGLANN 321 GL +L +G+D ++VG A+ Sbjct: 292 GLKEHLDKKGYDHFLQLVGKAHK 314 >UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales RepID=PYRD_SULSY Length = 311 Score = 277 bits (708), Expect = 6e-73, Method: Composition-based stats. Identities = 83/321 (25%), Positives = 153/321 (47%), Gaps = 18/321 (5%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L T G++F NP +S E+ + G +V K + P + +V Sbjct: 4 LKHTLFGLEFKNPVWTASGTFSYGLEVAKIYDLSLLGAIVVKGLSLKPRKGNMP--ERIV 61 Query: 66 KEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + G + ++ ++ + E L L++ D + A++ GE+E ++ +A + Sbjct: 62 ETPAGMLNSIGLQNPGVDYFINETLPKLKKY-----DTKIFANVFGEDEDEYLAVAERLD 116 Query: 125 EA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 +A G +E N SCP + G G PE++ +K+ + P+L K++PN+ ++ Sbjct: 117 KADGVHGLELNVSCPNVKKG--GIAFGTDPEVLYNLVYKMKKITKKPLLVKLSPNVSNIL 174 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 + A A GADG+ INT+ + ID+ ++ PI++ + G SG A+ PIA+R I Sbjct: 175 DTADACVSAGADGLVLINTLLGVA-IDVERE--KPILS--TITGGLSGPAMLPIAVRMIW 229 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q+ PI G+GGI ++DA + +L GA+ +QV T + L ++ Sbjct: 230 QVYQKYG-SRIPIIGVGGISNYKDALQHILAGASAIQVGTANFY-DPLSPLKIIEDLKNH 287 Query: 304 LADQGFDSLQEMVGLANNNIV 324 L +G+ +++G A+ I+ Sbjct: 288 LDKKGYVHYSQLIGKAHQMII 308 >UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEG1_METST Length = 306 Score = 273 bits (699), Expect = 7e-72, Method: Composition-based stats. Identities = 100/317 (31%), Positives = 165/317 (52%), Gaps = 15/317 (4%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L G+K NP L++ +G G GG+V K+ + +V Sbjct: 2 LEQEILGMKLSNPLFLAAGILGTTASSMKMVARAGAGGIVTKSFSIEANDGYDN--PTIV 59 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 K + G I + +E L L +++ P +IASI G++E+ + ++A ++ Sbjct: 60 KIEGGVINSVGLASPGVEAKKEELKDLNEIRDKTP---VIASIYGDSEEVFSDVANQTKD 116 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLAKMTPNIGDMCE 184 D E N SCP GS++G++PEL +VK +P++ K+TPN+ D+ E Sbjct: 117 Y-VDAFELNVSCPHAKC-GFGSNIGENPELTHDIVSSVKDNIKDVPIIVKLTPNVTDITE 174 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 +A AA+ GAD + IN+V ID K PI+N + G +G +KPIAL+ + + Sbjct: 175 IAKAAEDAGADALTLINSVGPGLRIDY--KTARPILN--NVFGGIAGPMIKPIALKCVYK 230 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 E D P+ G+GGI T++DA EFL GA+ LQ+ T IM G I +++ LS++L Sbjct: 231 TY---ETVDIPLFGVGGIRTYKDALEFLYAGASLLQIGTSIMYEGPEIFKNITHDLSNFL 287 Query: 305 ADQGFDSLQEMVGLANN 321 + G+ +++E++GL++N Sbjct: 288 EENGYKNVEEIIGLSHN 304 >UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9KKE5_9FIRM Length = 316 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 93/324 (28%), Positives = 147/324 (45%), Gaps = 19/324 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 M + L G+ P +S G E + GGV+ K Sbjct: 1 MSDERLHTNLLGIAMQTPVLTASGTFGFGEEFADFVDLSRLGGVMVKGTTLLPRRGND-- 58 Query: 61 FDHLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + + G + +E EH L+E L +++ +I +I G + + +L Sbjct: 59 GVRITETPKGMLNCIGLENPGVEHFLKETLPRIQQY-----GMNVIVNISGSTAEDYGKL 113 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 A L+ G IE N SCP + G G PE RA K + P++ K++PN+ Sbjct: 114 AGLLDVPGVAAIELNVSCPNVKEG--GIVFGTDPEAASAVVRAAKAHTKKPVILKLSPNV 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ +A A + GAD ++ INT+ + ID+++ P++ + G SG VKP+A+ Sbjct: 172 TDIVAMAKAVEAAGADAVSLINTLLGM-EIDIHRF--RPVLG--NITGGLSGPCVKPVAV 226 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ + PI G+GGI + EDA EF L GA+ + V T I + G Sbjct: 227 RMVWQVA---QAVHIPIIGMGGIASAEDAVEFFLAGASAVAVGTANFT-DPEITMKICDG 282 Query: 300 LSHYLADQGFDSLQEMVGLANNNI 323 L+ YLA+ GF S++E+VG AN Sbjct: 283 LTDYLAENGFSSIEEIVGKANPGF 306 >UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasmatales RepID=PYRD_THEVO Length = 301 Score = 268 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 89/320 (27%), Positives = 162/320 (50%), Gaps = 19/320 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 D+S T G+K NPF ++S + + + G VV K+IG + Sbjct: 1 MSDISTTLAGIKLVNPFMVASGILDENGYTMKELLERGAAAVVTKSIGISERDGYPT--P 58 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 +V+ I + E + + K +I S+ N +++ +L+ Sbjct: 59 VIVEYGDSLINAVGLSNPGIENFGEEINIAKEAKR-----PIIGSVFAYNAEEFTKLSVK 113 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 ++E G D IE N SCP + G +VG P+LVE +K +P+ AK++PN+ ++ Sbjct: 114 MEEYGVDAIELNLSCPHVKG--FGLEVGSDPDLVEDIVNEIKSKVKVPVFAKLSPNVSNI 171 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E+A AA++ AD INTVK++ ID+ + P+++ + G SG A+KP+ +R++ Sbjct: 172 IEIAKAAEK--ADAYVLINTVKAMA-IDIYSRS--PVLS--NLYGGLSGPAIKPVGIRYV 224 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 +++ I G+GGI ++DA E+++ GA+ +Q+ T + +YG I +M L Sbjct: 225 YEVKKETGKE---IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYGKGIFREMEWQLRT 281 Query: 303 YLADQGFDSLQEMVGLANNN 322 ++ ++ F+ ++EMVG+A Sbjct: 282 FMDEERFEKIEEMVGVAIKR 301 >UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YYV3_METPS Length = 315 Score = 263 bits (671), Expect = 1e-68, Method: Composition-based stats. Identities = 97/328 (29%), Positives = 157/328 (47%), Gaps = 23/328 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 T L++ G+ NP L++ +G + G G VV K+IG +P Sbjct: 9 TMKLTVEAGGLTLTNPTILAAGILGTTGASLKRVASMGAGAVVTKSIGAEPKYGHPNPSM 68 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L +G N +E L L K+ +IASI G E ++ E+A+ Sbjct: 69 IRLECGYINAMGLPNP------SYKEFLPELETAKDS--GVPVIASIFGATEAEFIEVAK 120 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + GA E N SCP + M VG P LV+ AVK P+ K+TPN+ D Sbjct: 121 GL--PGASAYELNVSCPHARGYGM--QVGTDPALVKAIAHAVKGTVNAPVWVKLTPNVTD 176 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + + AA+ GGAD + AINT+K+ I ++ G PI+ + G SG A+KP+A+R Sbjct: 177 ITSIGRAAQEGGADAVVAINTLKA---IAIDIDSGYPILG--NIQGGLSGPAIKPVAVRC 231 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + + + D P+ G GG+ +W DA EF++ GAA +++ + + + ++ GLS Sbjct: 232 VYDLYSAL---DIPVIGAGGVSSWADAVEFIMAGAAAVEIGSAV-YDDIGVFAAVSMGLS 287 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDL 329 YL + +L+++ G+A+ + D Sbjct: 288 DYLDRKNM-TLKDLTGMAHRMVKHEADK 314 >UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria RepID=PYRD_GEOTN Length = 313 Score = 263 bits (671), Expect = 1e-68, Method: Composition-based stats. Identities = 87/316 (27%), Positives = 141/316 (44%), Gaps = 20/316 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 L++ G+ NP +S G E + G ++ K +PR Sbjct: 3 RLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRVAE 62 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 IG +N + L E L L + D +IA+I G +++ E+A + Sbjct: 63 TPSGMLNAIGLQNPGL--DKVLAEELPWLEQF-----DVPIIANIAGSTMEEYVEVAAAI 115 Query: 124 QEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 +A +E N SCP + G G PE+ + R VK S +P+ K++PN+ D+ Sbjct: 116 SKAPNVHALELNISCPNVKKG--GIAFGTVPEVAAELTRLVKEVSAVPVYVKLSPNVTDI 173 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 +A A ++ GADG+ INT+ + ++ K G PI+ + G SG AVKPIA+R I Sbjct: 174 VAMAKAIEQAGADGLTMINTLVGMR---IDVKTGRPIL--ANGTGGLSGPAVKPIAVRMI 228 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 ++ + PI G+GG++T ED EF GA+ + V T + + + + L Sbjct: 229 YEVS---QAVSIPIIGMGGVQTAEDVLEFFYAGASAVAVGTANFIDPF-VCPTIINELPV 284 Query: 303 YLADQGFDSLQEMVGL 318 L + G + E G Sbjct: 285 LLDELGIRHISECTGR 300 >UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotate dehydrogenase B) catalytic subunit n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q4L5_9BACT Length = 306 Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats. Identities = 83/321 (25%), Positives = 154/321 (47%), Gaps = 15/321 (4%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 M LSI C ++ NP L+S +G + + ++G G V K++ Sbjct: 1 MTEVTLSINLCSMRLSNPTVLASGILGTTKTLLKRVAESGAGAVTIKSVSKDSREG---- 56 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 H T G N + +E L E +IASI+G + E+A Sbjct: 57 -HHNPTVITYEAGMLNAVGYSNPGVEAARIEYSNLNEI--GVPVIASIIGTCTDDFIEVA 113 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + +G IE SCP + S G +P+ + AV+R + +P+ K++PN+ Sbjct: 114 EGLSASGFSAIEIPLSCPHTPGFGLLSGQG-TPKATYEITYAVRRKTNVPIFVKISPNVP 172 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++ +A AA+ GA+GI A+N++ I++ K P++ K + G +G A++PIA+R Sbjct: 173 EITSIAKAAEDAGANGITAVNSMGPGMVINIESK--KPVLGFK--VGGVTGDALRPIAVR 228 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + + PI G+GGI T A E ++ GA+ + + TG+ G + + + + Sbjct: 229 CVYDVY---QAVKIPIIGVGGISTGRHAIEMMMAGASAVGIGTGVYTRGINVFSKVCAEM 285 Query: 301 SHYLADQGFDSLQEMVGLANN 321 ++ + G++++ E+VG+A++ Sbjct: 286 KQWMIENGYNTINELVGVAHD 306 >UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchaeota RepID=PYRD_UNCMA Length = 301 Score = 261 bits (668), Expect = 3e-68, Method: Composition-based stats. Identities = 97/321 (30%), Positives = 156/321 (48%), Gaps = 23/321 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 ++ G+ NP L++ +G + G G VV K+IG +P L Sbjct: 3 ITCNAGGLTLKNPTILAAGVLGTTGASLKRIASMGAGAVVTKSIGTEPKPGHHNPSMIRL 62 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + +G N E L +E +IASI G +++ +A + Sbjct: 63 EEGYINAMGLPNP------SFGEFRQELEIARES--GVPVIASIFGATPEEFTAVANGL- 113 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 GAD E N SCP + M G PELV +AVK +P+ K+TPN+ D+ Sbjct: 114 -PGADAYELNVSCPHAKGYGM--QCGTDPELVRSITKAVKAAVKVPVWVKLTPNVTDIRP 170 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 + LAA+ GGAD + AINT+K++ ID+N G PI+ +S G SG AVKP+A++ + Sbjct: 171 IGLAAQEGGADAVVAINTLKAMA-IDINT--GWPILGNRS--GGLSGPAVKPVAIKCVYD 225 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 + E+ D P+ G+GG+ W DA EF++ GA +++ + + ++ G+S+YL Sbjct: 226 LY---EVLDIPVIGVGGVSNWADAIEFMMAGACAVEIGSAV-YEDIGTFASVSMGISNYL 281 Query: 305 ADQGFDSLQEMVGLANNNIVP 325 + L E++GLA+ + Sbjct: 282 DRKNMK-LDEIIGLAHRVVKQ 301 >UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 Tax=Thaumarchaeota RepID=A9A3M4_NITMS Length = 303 Score = 261 bits (667), Expect = 3e-68, Method: Composition-based stats. Identities = 87/322 (27%), Positives = 155/322 (48%), Gaps = 20/322 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + +L+ + ++ P L+S +G ++ ++ Y +G G VV K++ +P Sbjct: 1 MEPNLATSIGPIQLDRPVMLASGILGISLDVFSRLYRSGAGAVVTKSLSTEPWEGYPNPT 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + G+ N ++ E + E D +I S++G + +E++ Sbjct: 61 IFSVKGG-----GWINAVGLSNPGAENFAKMI----EPNQDVPIIVSLVGSIPEDFEKMI 111 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + + E N SCP + +G +VG PELV+K VK + +P++AK+ Sbjct: 112 KQFENCKVTAYELNLSCPHVAK--VGLEVGDDPELVKKIVTTVKNSTNVPVIAKVGLGTT 169 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 A G D I AINTV+S+ ++ + PI++ K G SG +KPIALR Sbjct: 170 HYLNTVGTAIESGIDAITAINTVRSMA---IDVETQRPILSNK--FGGLSGTPIKPIALR 224 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ + D PI G GGI TWEDA EF L GA+++Q+ + I + ++ +G+ Sbjct: 225 CVYEISSKY---DIPIIGCGGISTWEDAVEFFLAGASSVQLGSAIGDNWIDVFNEINTGI 281 Query: 301 SHYLADQGFDSLQEMVGLANNN 322 Y+ + + ++EM+GLA + Sbjct: 282 LQYMEKKNYSKIEEMIGLAKKS 303 >UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2EKA7_TRIVA Length = 365 Score = 259 bits (663), Expect = 1e-67, Method: Composition-based stats. Identities = 102/394 (25%), Positives = 162/394 (41%), Gaps = 33/394 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 L F G + NP + P + C G G +V KTI A P Sbjct: 1 MSLKTKFAGYEVKNPLMPAPGPPVRDAKACIDCIKGGCGVMVTKTISVAAAKVPQPNMYE 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI--MGENEQQWEELAR 121 F N E E E+ L + ++ I I MG ++ ++A Sbjct: 61 SKDHKY----FLNTELWTELTPEQWLEHEYPKIREVCNQAKIPMICSMGYTAEEIAKMAP 116 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 V D +E ++H +G D + ++ A+ P+ K++P D Sbjct: 117 KVAPF-CDGLEL-------STHYIGDDPKPMQDAIK---AAIHGSGGKPVYVKLSP-FRD 164 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 A AAK GA G+ +N+ +D+ +K G P + S SG A+KP+ALR Sbjct: 165 APIAAKAAKAAGATGLVCVNSFGPTLALDIERK-GAPFMGSTSKYGWVSGPAIKPLALRV 223 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + + + D P+ G+GGI DA EFL+ GA L + T + G + +A +S Sbjct: 224 VYDV---CKEVDLPVVGVGGISNGRDAIEFLMAGAQALGICTAAIVEGRDVYGSIAQEMS 280 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQA 361 +L + G+ + E++GL + + P+I +KCVGCG C SC ++A Sbjct: 281 QWLTEHGYKDIHEVIGLGLKHEPLQQH------NPPKIAAEKCVGCGTCVTSCL---YEA 331 Query: 362 MEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 ++ + C+ KC C LC CP I + Sbjct: 332 LQLEDG--IAKCDGAKCFRCGLCYTRCPTCAISI 363 >UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus delbrueckii RepID=Q1G992_LACDA Length = 309 Score = 259 bits (663), Expect = 1e-67, Method: Composition-based stats. Identities = 101/319 (31%), Positives = 163/319 (51%), Gaps = 18/319 (5%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 +L++ G+K NP +S ++ G +V KT P+ D Sbjct: 6 NLAVELPGLKLKNPVMPASGTFAFG-DLPENFNWDEMGAIVLKTATRHARTGNPQPQIDL 64 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 L +G N AE E + ALR E +PD ++AS+ GE+ + + E+A ++ Sbjct: 65 LADGVMNAVGLTNPG--AEVVASEKIPALR---EKHPDLPILASVGGESVEDYVEVAEIL 119 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 A D +E N SCP ++ M G PE++EK R VK LP+ K+TPN+ + Sbjct: 120 AAAKPDALELNLSCPNVSEGGMT--FGIVPEMLEKITRLVKEKVDLPVYVKLTPNVTSIV 177 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E+A AA+ GGADG+ INT+ + ++DL + P++ + G G+AVKP+A+R + Sbjct: 178 EIAQAAEGGGADGLTLINTLL-VLHLDLKTR--RPVLG--NDFGGLYGQAVKPVAVRMVA 232 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q++ + PI G+GGI + EDAAEF+L GA+ +Q+ + + Y ++ + GL Sbjct: 233 QVK---QATSLPIIGVGGINSPEDAAEFILAGASAVQIGS-MSFYDKLAIKHVIDGLPAV 288 Query: 304 LADQGFDSLQEMVGLANNN 322 LA G + +VG +N Sbjct: 289 LAGMGASDVTSLVGQWQSN 307 >UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=PYRD_CARHZ Length = 307 Score = 259 bits (661), Expect = 2e-67, Method: Composition-based stats. Identities = 81/320 (25%), Positives = 144/320 (45%), Gaps = 20/320 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L + + NP +S G E G +V KTI + R Sbjct: 1 MNLKVKIGELTLKNPVMPASGTFGFGLEFKDIFDLKNLGALVVKTITKNP--RLGNRPPR 58 Query: 64 LVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + + G I + ++ E+ L ++ L + +LI +I GE+ ++++ LAR Sbjct: 59 VYEVSCGMINSIGLANPGWDYFCEKILPQIKDLND-----ILILNIAGESVEEFQYLARE 113 Query: 123 VQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 Q +E N SCP ++ G G E +++ +V++ + ++ K+TPN+ D Sbjct: 114 AQRFDEIKALELNVSCPNVSKG--GIAFGTDLEALKQIVSSVRKIYSKTLIVKLTPNVTD 171 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + A AA+ GAD + INT + ++ K PI+ K G SG A++P+A++ Sbjct: 172 ITVYAKAAENAGADALTLINTFTGMV---IDVKSKKPILGNKH--GGVSGPAIRPMAVKM 226 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + PI G+GGI++ E A EF L GA +QV + + + L Sbjct: 227 VYDCFKA---VSIPIIGVGGIDSKEAALEFFLAGATAIQVGSQNFVE-PGFMPRLIRELG 282 Query: 302 HYLADQGFDSLQEMVGLANN 321 YL ++ +S+ ++ GLA+ Sbjct: 283 EYLQEENIESIAKLTGLAHR 302 >UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=C8WHP0_EGGLE Length = 356 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 141/320 (44%), Gaps = 19/320 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPR 60 + D+ + G++ NP ++S E G G V K + A SPR Sbjct: 54 TSVDMRVNLGGLEMKNPVTVASGTFAAGREYGDFVDVAGLGAVTTKGVSLNGWAGNASPR 113 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 IG +N H E +L L +I ++ G + ++ ++ Sbjct: 114 IAETPSGMLNSIGLQNPG--VAHLKECDLPWLAE-----RGATVIVNVSGHSFDEYVQVI 166 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 +++ D E N SCP + + M +G + VE + + P++ K+TPN+ Sbjct: 167 EALEDVPVDAYEVNISCPNVDAGGMT--IGTCTDSVEAVVSRCRAATKRPLIVKLTPNVT 224 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ E+A AA GAD ++ INT+ + ID ++ + G SG AVKP+ALR Sbjct: 225 DVTEIARAAVSAGADALSLINTLLGMA-IDAERRRPQ----LARGVGGLSGPAVKPVALR 279 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ + D P+ G+GGI DA EF+L GA + V T + V ++ G+ Sbjct: 280 MVWEVH---QAVDVPLLGMGGISCATDAVEFMLAGATAVAVGTANFVNPHATV-EIIDGM 335 Query: 301 SHYLADQGFDSLQEMVGLAN 320 + Y G + +Q+++G Sbjct: 336 AQYCERHGIEDVQQLIGALE 355 >UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidales RepID=PYRD_BACV8 Length = 303 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 82/320 (25%), Positives = 146/320 (45%), Gaps = 20/320 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFK-TIGFFIANEVSPRF 61 DLS+ +K NP +S G E GG++ K T PR Sbjct: 1 MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRM 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 +G +N ++ +E +R + + +I ++ G + + + A Sbjct: 61 AETPMGMLNAVGLQNKG--VDYFVEHIYPQIRDIHTN-----MIVNVSGSAVEDYVKTAE 113 Query: 122 LVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ + IE N SCP + M G S + +AV+ ++ K++PN+ Sbjct: 114 IINDLDHIPAIELNISCPNVKQGGM--AFGVSACGCSEVVKAVRNVYKKTLIVKLSPNVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ E+A AA+ GAD ++ INT+ + ++ + P+++ + G SG AVKPIALR Sbjct: 172 DITEIARAAEASGADSVSLINTLLGMA---VDAEKRRPVLS--TITGGMSGAAVKPIALR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q+ + P+ G+GGI W+DA EF+L GA +Q+ T I ++ G+ Sbjct: 227 MVWQVAKAV---NIPVIGLGGIMGWKDAVEFMLAGATAIQIGTANFI-DPAITVKVSEGI 282 Query: 301 SHYLADQGFDSLQEMVGLAN 320 + YL G+ S+++++G Sbjct: 283 NDYLERHGYTSVKDIIGALE 302 >UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomus RepID=B5YFH3_DICT6 Length = 306 Score = 258 bits (658), Expect = 4e-67, Method: Composition-based stats. Identities = 88/325 (27%), Positives = 148/325 (45%), Gaps = 22/325 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 +L + + F NP L+S GN E+ G GG V K+I PR Sbjct: 3 NLEVRIGSLIFKNPILLASGTCGNGREINKFYDINGLGGFVTKSITLNPREGNPPPRIWE 62 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 IG +N+ + LEE + L RL + +I SI GE ++++ E+AR + Sbjct: 63 SYAGILNSIGLENVGL--QKFLEEEMPFLERLSTN-----VIVSIAGEKKEEYYEIARNL 115 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + +E N SCP + M G E+V++ + V + P+ K+TP D+ Sbjct: 116 RGCKISGVELNLSCPNVEGGGML--FGIDKEMVKEITKKVVKEIGKPVWVKLTPQAKDIV 173 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E+ A K G + + NT + ID ++ P+ K +GYSG AVKP+ LR++ Sbjct: 174 EIVKAVKDAGGEAVVLFNTFLGLA-IDWKKR--KPVF--KRIFAGYSGPAVKPLVLRYVW 228 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ E PI G GGI ++ D E++ GA+ +Q+ + + I E + Y Sbjct: 229 EVY---EENLLPIVGCGGIVSFSDVLEYIFAGASLVQIGSANFR-DPWIGERLVKEAFKY 284 Query: 304 LADQGFDSLQEMVGLANNNIVPAED 328 + + +++G+A+ N E+ Sbjct: 285 FEK---ERVMDLIGIAHKNYKEVEE 306 >UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_THEYD Length = 303 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 82/314 (26%), Positives = 144/314 (45%), Gaps = 20/314 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + + F NP +S G E GG+V K + PR Sbjct: 4 LEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRIYET 63 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 IG +N+ E +E L L++ + +I + GEN ++ E+A+L+ Sbjct: 64 PCGMINSIGLQNIGL--EAFKKEKLPFLKKFNTN-----IIVNFFGENLDEYIEVAKLLD 116 Query: 125 EA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 E G +E N SCP TS +G PEL+ + + V+ P++ K+ P + ++ Sbjct: 117 ETEGVHALEMNVSCPNKTSE--WRKMGLEPELLREAIKRVRLHIKKPLIVKLAPQVTEIA 174 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +A + GAD ++ INT+ ++ ID+ + M + G SG A++P+ALR + Sbjct: 175 LMARICEEEGADAVSLINTIPAMV-IDIKTRKSMI----GTLTGGLSGPAIRPVALRAVW 229 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ + P+ G+GGI + EDA +FL+ GA +QV T V ++ G+ + Sbjct: 230 EVA---QAVKIPVIGVGGIVSAEDALQFLIAGAKAIQVGTANFINPIATV-EIIEGIKQF 285 Query: 304 LADQGFDSLQEMVG 317 L ++ + E++G Sbjct: 286 LIEENIKDINEIIG 299 >UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+] (DPD) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase) (PydA) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VG14_9BACT Length = 821 Score = 255 bits (651), Expect = 3e-66, Method: Composition-based stats. Identities = 115/412 (27%), Positives = 187/412 (45%), Gaps = 32/412 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L F G K +PF LS++P + YE KAY GW G + KT F ++ + Sbjct: 427 PVSLETDFFGRKMDSPFILSAAPPSDGYEQMKKAYLAGWSGGIMKT--AFDNEDIHIPGE 484 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-------ENEQQ 115 ++ F N + ++EHPL+ + + L +++PD++ +AS G +++ Sbjct: 485 YMFTFGDKKKTFANCDNVSEHPLDRVCSEIALLIKEFPDRLTMASTGGPVTGDDINDKKG 544 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPMLA 173 W+ +++AGA IE + SCPQ G V Q P L K V S +P L Sbjct: 545 WQANTIKLEKAGAMGIEYSLSCPQGGDGTKGDIVAQDPALTAKIIDWVMEISNPEIPKLF 604 Query: 174 KMTPNIGDMCEVALAAKR------GGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 K+T + + + A K G GI NT ++ + + I+ Sbjct: 605 KLTGAVTSIYPILSAVKSVLDKYPGKKAGITLANTFPALAFREKEKPWDEGIIV------ 658 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+++ PI+ + + ISG GG + DAA FL LGA +Q T + + Sbjct: 659 GLSGESILPISYLNLAR----AGNSGIFISGNGGAMNYLDAANFLALGAGNVQFCTIVEK 714 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGC 347 YGY I++++ GLS+ L +G S+ E++G+A + + + + C+ C Sbjct: 715 YGYGIIDELKMGLSYLLEAKGLKSVAELIGIAQPKPITDFLDLPTKTKSSSLIKELCLKC 774 Query: 348 GRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 G C +QA+E E P + +KCVGC LC +C G +E+ K Sbjct: 775 GNCTRC----PYQAIELDEDCY-PKIDPDKCVGCSLCTQLCFAGALEMKNEK 821 >UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=PYRD_SOLUE Length = 304 Score = 254 bits (650), Expect = 3e-66, Method: Composition-based stats. Identities = 90/321 (28%), Positives = 143/321 (44%), Gaps = 20/321 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 +T L+ T CG+ NP +S E GG V K + P Sbjct: 1 MTPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPP-- 58 Query: 62 DHLVKEDTGFIGFKNMEQIAEH-PLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + + + G I ++ I + E L AL L+ + A++ G + + E+ Sbjct: 59 PRVFESEAGMINSVGLQNIGVRAFVAEKLPALAGLR-----TAVFANVFGYCTEDYVEVV 113 Query: 121 RLVQE-AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 R++ + AG E N SCP G P L+ + A KR +T P++ K++PN+ Sbjct: 114 RVLNDHAGLAGYELNVSCPNTAHG--GIYFSNDPVLLAEVVTAAKRVATRPLIVKLSPNV 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 + +A A+ GAD ++ +NTV S+ ++ + P + G SG A+KPIAL Sbjct: 172 SAIEPLARVAEESGADALSLVNTVISLA---IDARTRRPRIGA--GFGGLSGPAIKPIAL 226 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 RF+ Q P+ G+GGI T EDAAEFL+ GA+ ++V T R +A Sbjct: 227 RFVYQAARAVR---IPVIGLGGIATGEDAAEFLIAGASAVEVGTATFW-DPRAPLRIAEE 282 Query: 300 LSHYLADQGFDSLQEMVGLAN 320 L +L +G ++VG Sbjct: 283 LGKFLEREGIRKATDLVGTLK 303 >UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine dehydrogenase n=1 Tax=Acyrthosiphon pisum RepID=UPI0001791DE1 Length = 1286 Score = 253 bits (647), Expect = 8e-66, Method: Composition-based stats. Identities = 117/358 (32%), Positives = 163/358 (45%), Gaps = 54/358 (15%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF--FIANEVSPRFD 62 DLS+ CG++F NPF L+S+P M +A+ GW V KT G + VSPR Sbjct: 684 DLSVRMCGLRFMNPFGLASAPPTTSAAMIRRAFQAGWAFAVTKTFGLDKDLVTNVSPRIV 743 Query: 63 HLV---------------------KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPD 101 L D F N+E I+E L ++R LK D+P Sbjct: 744 GLGGHGVGVGSAASGIGPGTLGAGDSDVARNAFLNIELISEKTAAYWLRSIRELKRDFPQ 803 Query: 102 KVLIASIMG-ENEQQWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKY 159 +LIASIM E W LARL +AGAD +E N SCP M MG GQ P LVE Sbjct: 804 HILIASIMCAYIENDWTSLARLACDAGADALELNLSCPHGMGESGMGLACGQDPVLVENI 863 Query: 160 CRAVKRG-----------STLPMLAKMTPNIGDMCEVALAAKR-GGADGIAAINTVKSIT 207 R VKR + +P+ K+TPN+ D+ VA AA R GGADG+ A+NTV ++ Sbjct: 864 SRWVKRVAVRPASDGGTPTAVPVFVKITPNVTDVVAVARAAVRLGGADGVTAVNTVSALG 923 Query: 208 NIDLNQKIGMPIVN--------GKSSISGYSGKAVKPIALRFIQQMRTHP---------E 250 +D+ G P +++ G SG AV+P+ LR + + Sbjct: 924 PLDVTGNGGRPWPGVGRTTAETPRTTYGGMSGTAVRPMGLRAVSALSRALGPDATAGGDG 983 Query: 251 LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 I GG+++ ++L GA +QV + + + IV+D +GL L G Sbjct: 984 GPPVQIMATGGVDSAAATLQYLYCGAKVVQVCSAVQNQDFTIVQDYITGLKALLYMTG 1041 Score = 96.7 bits (239), Expect = 1e-18, Method: Composition-based stats. Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 1/87 (1%) Query: 312 LQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTP 371 ++ VG A + + LDR V +N D C+ CG+CY++C D G+QA+ K+ Sbjct: 1146 VELAVGRALKAVGAYKSLDRRAQVVALVNEDSCINCGKCYMACNDSGYQAITMDPKSHAV 1205 Query: 372 HCNTEKCVGCLLCGHVCPV-GCIELGE 397 H + C GC LC VCP+ GCI + E Sbjct: 1206 HVQPDSCTGCTLCLTVCPIPGCISMVE 1232 >UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria RepID=PYRD_PETMO Length = 300 Score = 253 bits (645), Expect = 1e-65, Method: Composition-based stats. Identities = 82/315 (26%), Positives = 141/315 (44%), Gaps = 19/315 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 D + GV+F NP +S G E + GG+ K + R Sbjct: 3 DTKVNIAGVEFKNPVIAASGTFGFGREFLEYFPISKLGGLATKGLTLREREGNKGVRIHE 62 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 + IG +N + +EE L L + D V+IA++ G ++ + Sbjct: 63 TIGGIMNSIGLQNPGI--DAFIEEELPFL-----NSQDTVIIANVSGNTIDEYVISVEKL 115 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + DMIE N SCP + G G E+ V++ P++ K++P+ ++ Sbjct: 116 NQTDIDMIELNISCPNVKEG--GISFGTKAEIASNVVTQVRKVCQKPLIVKLSPSAENIV 173 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E+A + GAD ++ +NT ++ ID+++K + + +G SG +KPIALR + Sbjct: 174 EMAESCVEAGADALSLVNTFPALA-IDISKKKAI----FDNITAGLSGPCIKPIALRMVY 228 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ D PI GIGGI + DA E+++ GA +QV T ++ G+ Y Sbjct: 229 EVSKAV---DVPIIGIGGIMDYRDAIEYIMAGAWAVQVGTANFIN-PNACAEIIEGIEEY 284 Query: 304 LADQGFDSLQEMVGL 318 L +G +L+E+ G+ Sbjct: 285 LQKEGISTLEEIRGI 299 >UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria RepID=PYRD_DESAP Length = 307 Score = 251 bits (642), Expect = 3e-65, Method: Composition-based stats. Identities = 96/323 (29%), Positives = 151/323 (46%), Gaps = 20/323 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + ++ G+ NP +S VG E G G +V KT+ A PR Sbjct: 1 MKVKTAVAIAGLTLKNPVLTASGTVGFGEEYAPYLDLAGLGALVVKTVTLKPRAGNPPPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 +G +N E + + L L R D +I SI GE ++ LA Sbjct: 61 ITETPAGVINAVGLQNPG--VEALVRDILPRLARF-----DVPVIVSIAGETVDEYARLA 113 Query: 121 RLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + G +E N SCP + + G G P + R V+ + LP++AK++PN+ Sbjct: 114 GRLDGVPGIAALEVNISCPNVKAG--GIAFGTEPAMTAAVVRQVRENTRLPVIAKLSPNV 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ +ALAA GAD ++ INT+ ++ ID+ ++ P++ + G SG AV+P+A+ Sbjct: 172 TDIRTIALAAAGAGADALSLINTLSAMV-IDVERR--RPLLG--NVFGGLSGPAVRPVAV 226 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ EL P+ G+GGI T DA EF+L GA + V T + +A+ Sbjct: 227 RAVWQVYQAVEL---PLIGMGGIMTARDALEFILAGARAVAVGTANLVN-PGAAAAVAAD 282 Query: 300 LSHYLADQGFDSLQEMVGLANNN 322 L YL +QG + E+VG A+ Sbjct: 283 LEQYLTEQGIRDINELVGAAHRT 305 >UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D3W9_DESK1 Length = 302 Score = 247 bits (631), Expect = 5e-64, Method: Composition-based stats. Identities = 91/319 (28%), Positives = 155/319 (48%), Gaps = 20/319 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + + L + G++ +P +S +G+ E G+ +V KTI P Sbjct: 1 MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 ++ + G N +A P + L R + K LI SI G + +++ +LA Sbjct: 61 IVELRNN----GLLNAVGLAN-PGARVIPVLARKAREL-SKPLILSIGGSSVEEFVKLAE 114 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 L EAG D +E N SCP + G ++G P LV + + ++LP++AK+ + D Sbjct: 115 LASEAGVDAVELNLSCPHAEGY--GLELGSDPMLVYRIVKDAVSVASLPVIAKL--GLTD 170 Query: 182 -MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + E A A G + INTVK+++ ++ P+++ K G SG + PIA+R Sbjct: 171 RVIESAGKALEAGVKALTLINTVKAMS---IDVYTLKPVLSNK--YGGLSGPPIHPIAVR 225 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + I G+GG+ +W D AE +L GA +QV T ++ IV+++ SGL Sbjct: 226 VVYDVYREYRAE---IIGVGGVSSWMDVAELILAGARAVQVGTALIWN-ENIVDEILSGL 281 Query: 301 SHYLADQGFDSLQEMVGLA 319 +L D G++SL ++VG+A Sbjct: 282 HKWLIDLGYNSLMDLVGIA 300 >UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39 Tax=cellular organisms RepID=PYRD_HUMAN Length = 395 Score = 246 bits (629), Expect = 8e-64, Method: Composition-based stats. Identities = 73/329 (22%), Positives = 132/329 (40%), Gaps = 23/329 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + G KF NP +++ + E Y G+G V ++ PR L Sbjct: 78 LEVRVLGHKFRNPVGIAAGFDKHG-EAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRL 136 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP-DKVLIASIMGENE---QQWEELA 120 + D I +E L A ++ + D + + +G+N+ E+ A Sbjct: 137 PE-DQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYA 195 Query: 121 RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPMLAKM 175 V+ G AD + N S P + L+ K + ++R +L K+ Sbjct: 196 EGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKI 255 Query: 176 TPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D ++A K G DG+ NT S +S G SGK Sbjct: 256 APDLTSQDKEDIASVVKELGIDGLIVTNTTVSRP--------AGLQGALRSETGGLSGKP 307 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 ++ ++ + I++M + PI G+GG+ + +DA E + GA+ +Q+ T + +G +V Sbjct: 308 LRDLSTQTIREMYALTQ-GRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVV 366 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNN 322 + L L +QGF + + +G + Sbjct: 367 GKVKRELEALLKEQGFGGVTDAIGADHRR 395 >UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A1L2_THESM Length = 309 Score = 246 bits (627), Expect = 2e-63, Method: Composition-based stats. Identities = 95/322 (29%), Positives = 155/322 (48%), Gaps = 21/322 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + DLSI G+KF NP L+S PVG +E+ + G + KT+ P Sbjct: 1 MGVDLSIDVFGIKFRNPIILASGPVGFGFELMPYLDFSNIGAITLKTVTLKPREGNPP-- 58 Query: 62 DHLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 LV G I ++ E +EE L+ LK + I SI G + +WE L Sbjct: 59 PRLVDSHGGVINSIGLQNPGIEGFVEEIAPRLKELK-----TIKIGSIAGFSMDEWEILG 113 Query: 121 RLVQ-EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + +IE N SCP + ++ +L EK + V++ + P++AK+ P++ Sbjct: 114 EEMDKIKEIKIIEINLSCPNVKGKRRWAE---DAKLTEKVVKIVRKLTGKPIIAKLAPDV 170 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E+A A GADG+ N +++ ++ + G+PI+ K+ G G AVKPI L Sbjct: 171 TDIVEIAKTAVDAGADGLTIGNGAQAMR---IDVETGLPILKLKT--GGLGGPAVKPITL 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + + R E D PI GIGGI W+DA E+ + GA+ L + T +M + G Sbjct: 226 AKVFKTR---EALDVPIIGIGGIMNWQDAIEYAMAGASLLGLGTAVMV-DPEAPVRIIEG 281 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 + +L + +S +++G+A+ Sbjct: 282 IKAFLERKKIESFNKIIGVAHK 303 >UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10 Tax=Proteobacteria RepID=Q3J7C7_NITOC Length = 331 Score = 245 bits (626), Expect = 2e-63, Method: Composition-based stats. Identities = 80/316 (25%), Positives = 140/316 (44%), Gaps = 18/316 (5%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG--WGGVVFKTIGFFIANEVSPRFD 62 L + FCG++ +P L S VG E + G V K G A + Sbjct: 16 RLKVDFCGLELQSPLVLLSGCVGFGEEYTRVVGFSNREVGAVCLK--GTTAAPRLGNALH 73 Query: 63 HLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + G + ++ ++ ++ L AL D+ + IA++ G +++ + R Sbjct: 74 RIYETPMGMLNAIGLQNPGVDYVVDHILPAL-----DFSETRYIANVSGSTIEEYTAVTR 128 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + D IE N SCP + G G P + + A ++ + P++ K++PN Sbjct: 129 RFDNSPIDAIEINISCPNVKEG--GVAFGNDPHMSARVVEACRKVTRKPLITKLSPNQTS 186 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E A G DG A INT+ + ID+ Q+ P++ + G SG A+KPIAL Sbjct: 187 IEENARRCIEAGTDGFAVINTLMGMA-IDIEQRT--PLLG--NIQGGLSGPAIKPIALLK 241 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 ++Q+ PI G GG+ + +DA EFL+ GA T+ V T + + + + + Sbjct: 242 VRQVYQACRAHGIPIIGQGGVASGKDALEFLIAGATTVGVGTALFY-DPLLCAKINAEIV 300 Query: 302 HYLADQGFDSLQEMVG 317 YL ++ ++ G Sbjct: 301 AYLKRHDLRAVAQLTG 316 >UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14 Tax=Drosophila RepID=PYRD_DROME Length = 405 Score = 244 bits (623), Expect = 4e-63, Method: Composition-based stats. Identities = 79/335 (23%), Positives = 137/335 (40%), Gaps = 27/335 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 ++L +F G NP +++ N E D G+G + T+ PR Sbjct: 84 QNLHTSFFGRMLSNPIGIAAGFDKN-AEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVF 142 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L ED I + L LR L++ ++ +G N+ +A Sbjct: 143 RL-TEDKAIINRYGFNSDGHQAV---LQRLRLLRKKENFNGVVGVNLGRNKTTMSPIADY 198 Query: 123 VQEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC---RAVKRGSTLPMLAK 174 VQ AD + N S P + EL+E+ ++ + +P+L K Sbjct: 199 VQGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLK 258 Query: 175 MTPNIG--DMCEVALAAKRGG--ADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 ++P++ DM ++ KR DG+ NT S NI+ N+ G S Sbjct: 259 LSPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKL--------AEETGGLS 310 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G +K + I QM + + PI G+GG+ + DA E + GA+ +Q+ T ++ G Sbjct: 311 GPPLKARSTEMIAQMYQLTDGK-IPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGP 369 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVP 325 +VED+ + LS + G ++ ++VG + +P Sbjct: 370 ALVEDIKAELSALITRLGHTNVADVVGTNSKFYLP 404 >UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular organisms RepID=Q5PR57_DANRE Length = 407 Score = 243 bits (621), Expect = 7e-63, Method: Composition-based stats. Identities = 70/334 (20%), Positives = 130/334 (38%), Gaps = 23/334 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L + G KF NP +++ + E Y G+G V T+ PR Sbjct: 74 PTSLEVHVMGRKFQNPVGMAAGFDKHG-EAVDGLYRLGFGFVEVGTVTPKPQDGNPKPRV 132 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPD-KVLIASIMGEN---EQQWE 117 L + D I + E L A ++ + + +G+N Sbjct: 133 FRL-ESDQAVINRYGFNSCGLSAVHERLKAREHVQSELTKAGKPLGINLGKNKLSPDAVS 191 Query: 118 ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPML 172 + V+ G AD + N S P + L++K + ++ + P+L Sbjct: 192 DYVEGVRTLGPLADYLVVNVSSPNTPGLRDLQGKEELRHLLDKVVKERDSLRIENRPPVL 251 Query: 173 AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ D ++A G DG+ NT S + + + G S Sbjct: 252 VKIAPDLTTQDKQDIAEVIMEVGVDGVMVSNTTVSRPDTLKDP--------NRVETGGLS 303 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G+ +K ++ + +++M T + + PI G+GG+ + +DA + + GA+ +Q+ T ++ G Sbjct: 304 GQPLKELSTQTVREMYTLTQGK-LPIVGVGGVASGQDAMDKIRAGASLVQLYTALVYQGP 362 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIV 324 +V + L L QGF + E VG + Sbjct: 363 PVVNKIKRELDDLLKAQGFTCVAEAVGADHKTTE 396 >UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira RepID=PYRD_BRAHW Length = 303 Score = 243 bits (620), Expect = 1e-62, Method: Composition-based stats. Identities = 83/320 (25%), Positives = 150/320 (46%), Gaps = 20/320 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L+I F G + N SS G E G V K I + + Sbjct: 1 MSRLNINFLGKELKNNVITSSGCFGFGEEYSNYFDVNELGAVNLKGITLN--KKDGNKGT 58 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + + +G I +E ++N+ ++ +K P +I +I G ++ ++A + Sbjct: 59 RIAETPSGMINCIGLENPGIEYFKDNI--IKNIKYSTP---IILNINGATIDEYVKVAEI 113 Query: 123 VQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPMLAKMTPNIG 180 E D +E N SCP + + M G S E E +AVK+ S P++ K++PN+ Sbjct: 114 ANEIERVDFVELNISCPNVKNGGM--AFGASCESAESTTKAVKKVLSKKPLIVKLSPNVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ +A A + GAD ++ +NT S+ ++ K P++ + G SG ++PIA+R Sbjct: 172 DIASIAKAVEDAGADSVSLVNTFLSM---KIDTKTRKPLLG--NIFGGLSGACIRPIAVR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q+ + PI G+GGI + DA EF+L GA+ + + GI +E + G+ Sbjct: 227 MVYQVYKAVK---IPIVGMGGITNYNDALEFILAGASLVSIGAGIFSNPILPIEVIN-GI 282 Query: 301 SHYLADQGFDSLQEMVGLAN 320 +YL + ++++++G A+ Sbjct: 283 DNYLKENNISNIKDIIGAAH 302 >UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_ANASP Length = 343 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 68/342 (19%), Positives = 130/342 (38%), Gaps = 21/342 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL+ + G++ +P S+SP+ + D G VV ++ + S H Sbjct: 1 MDLTTNYLGLRLRSPLVPSASPMSGEIDNILWMEDAGAAAVVLPSLFEEQLSLESYELHH 60 Query: 64 LVKEDTGFIGFKNMEQIAEH-----PLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + T +++ EH EE L +++ KE +IAS+ G + W E Sbjct: 61 HLTYGTESFP-ESLTYFPEHQDFRLGSEEYLNLIQKTKEKV-KIPIIASLNGSSLDGWTE 118 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 AR++++AGA +E N + QS + VK +P+ K++P Sbjct: 119 YARMIEQAGAAALELNTYSVHTDPELTSEQIEQSY---INMLKVVKASVQIPVAIKLSPY 175 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 +M +A GAD + N +I+L P V S + Sbjct: 176 FTNMANMAKRLDDAGADALVLFNRFYQ-PDINLETLEVQPHVL-------LSTPQAMRLP 227 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR+I + H ++ GI D + L+ GA + + ++++G + + Sbjct: 228 LRWIAILYGHINAH---LAATSGIHNGHDVLKMLMAGANITMLCSVLLRHGIDHIRCIEQ 284 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 +S ++ ++S+Q++ G + P + Sbjct: 285 EMSQWMEKHEYESVQQLQGSMSQKHCPNPSAFERAQYMRALQ 326 >UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5E1_CHRVI Length = 338 Score = 240 bits (613), Expect = 5e-62, Method: Composition-based stats. Identities = 79/343 (23%), Positives = 149/343 (43%), Gaps = 28/343 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L T+ G+ NP S+SP+ + D+G +V ++ + Sbjct: 1 MNLKTTYLGLTLKNPLVPSASPLSRSLSAAREMEDSGAAAIVMYSLFEEAITAEAESMTR 60 Query: 64 -LVKEDTGFI----GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 L +DTGF GF Q E+ LE L +RRLKE D +IAS+ G W + Sbjct: 61 FLHHQDTGFAESSAGFLPDHQDFENGLERYLEQIRRLKESL-DIPVIASLNGVTTGGWVK 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK----YCRAVKRGSTLPMLAK 174 A +Q+AGAD +E N + D+ Q+ VE+ ++ +P+ K Sbjct: 120 HALELQQAGADALELNVY-------YIAGDISQNGAQVEQRYLDLLTELRGRIRIPINMK 172 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 ++P+ + GA+G++ N +I+++ ++ +S Sbjct: 173 LSPSFSSIGHFVGRLAAAGANGVSLFNRFYQ-PDINIDSLRLQARLHPSTSAEAL----- 226 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 +A+R+I + + + GGI T EDA + LL GA + + + ++Q G Sbjct: 227 --LAMRWIALLYGR--VPGLSLGATGGIHTSEDAIKLLLAGADVVHLCSVLLQKGPVYTG 282 Query: 295 DMASGLSHYLADQGFDSLQEMVGLANN-NIVPAEDLDRSYIVY 336 + G++ ++ +QGF+S+++ G + + +L+R+ + Sbjct: 283 LILRGIADWMEEQGFESVEDFRGRVSALTVPNPAELERANYIN 325 >UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=PYRD_UNCTG Length = 306 Score = 240 bits (613), Expect = 6e-62, Method: Composition-based stats. Identities = 87/322 (27%), Positives = 153/322 (47%), Gaps = 22/322 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + DLS+ F G+K NP +S G YE+ GGVV KT+ A + PR Sbjct: 1 MIPDLSVNFAGIKLKNPVLTASGTFGYGYELADLIPLKRLGGVVTKTVTLEPRAGNLQPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + IG +N+ +EE L L ++ +I S+ G ++ E+ Sbjct: 61 IAEVASGILNSIGLQNIG--VRAFIEEPLEKLNKI-----GVPVIVSVAGVAVGEYVEIV 113 Query: 121 RLV-QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 +++ + G IE N SCP + + D+ L+ R VK+ S +P++AK++P + Sbjct: 114 KILSSQNGVSAIELNLSCPNLKKKIVCHDL----PLMRDVIRGVKKVSRVPVIAKLSPLV 169 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E+AL A+ GADG+ NT ++ ++ + P ++ + G SG +KP+++ Sbjct: 170 TDISELALTAQNAGADGVTLTNTYPAMA---VDIRTFKPKLS--TVKGGMSGACIKPMSV 224 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + + PI G GGI EDA EF+L GA + V + + ++ + G Sbjct: 225 RCVYDAY---QDIKIPIIGCGGIMMGEDAVEFILAGATAVSVGSSSLVSPGNLIA-IIDG 280 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 + L ++ S+++++G N Sbjct: 281 IEDILKEKNIKSVKKIIGGINK 302 >UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4J6_GEMAT Length = 327 Score = 240 bits (612), Expect = 9e-62, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 130/317 (41%), Gaps = 18/317 (5%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 S++ G+ F NP L+S G E+ + GG+ K + + R Sbjct: 23 SVSVAGLAFRNPVVLASGTAGFGQELEDVLDLSAVGGISTKAVSVAPRPGNPALRVSEFA 82 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 IG N + L L +P + +++G + + + + R + + Sbjct: 83 GGMMNAIGLANPGLESVRR-----DYLPWLPAHHPGTRVFVNVVGNSIEDFATVVRGLDD 137 Query: 126 A-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD-MC 183 G D E N SCP + + G + G P+ + A + + P+ K++P +G + Sbjct: 138 VPGVDAFELNVSCPNVKAG--GLEFGADPQALHALVSAARGATKRPIFVKLSPTLGAAIA 195 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 + A A GA G+ +NT + ++ P ++ G SG A+ P+ L Sbjct: 196 DTARVAVDAGATGLTLVNT---MPGTVIDTDRRRPKLSF--GSGGVSGPALLPVGLLATW 250 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ L P+ G+GGI T +DA ++L+ GA+ + V T ++ R E + L + Sbjct: 251 RVSRA--LPTVPLIGLGGISTGDDALQYLMAGASLVGVGTAALR-DPRAPERIVRQLQRW 307 Query: 304 LADQGFDSLQEMVGLAN 320 +G + ++G Sbjct: 308 CDREGVRDITTLIGTLQ 324 >UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Leuconostoc citreum KM20 RepID=B1MZ73_LEUCK Length = 306 Score = 238 bits (606), Expect = 4e-61, Method: Composition-based stats. Identities = 83/318 (26%), Positives = 147/318 (46%), Gaps = 19/318 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 M+++ L++ G+ NP SS V E A + G +V KT+ A P Sbjct: 1 MMSERLAVKLPGLDLKNPIMNSSGAVFFGLEDKGYAIEE-TGALVTKTVTMSARAGNPQP 59 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 ++ +G + + + ++ L + E Y ++AS+ GE ++ L Sbjct: 60 W---IINTPSGILNSVGLANPGIEAVVADI--LPAIHEKYKTLPVLASVAGETVGEYVAL 114 Query: 120 ARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 + IE N SCP + M G + E + A++ +TLP+ AKM+PN Sbjct: 115 TERLTATKQVTAIEANLSCPNVDRGGM--AFGVTAESAAEVIHAMRAATTLPIYAKMSPN 172 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ + A + GADGI INTV ++ +DLN + G SG +V PIA Sbjct: 173 VTDIKPIVKAVETAGADGIVLINTVVGMS-LDLNTRQAR----LARGTGGMSGTSVHPIA 227 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +RF+ + + P+ G+GG+ T +D E ++ GA+ +Q+ T + ++++ D+ Sbjct: 228 VRFVYETA---QTVSIPVIGVGGVSTVDDVLELMMAGASAVQIGTALAGN-HQVMADIIR 283 Query: 299 GLSHYLADQGFDSLQEMV 316 L L GF +++E+ Sbjct: 284 ELPSALDKYGFSNVEEVT 301 >UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 Tax=Archaea RepID=A1RZC9_THEPD Length = 299 Score = 236 bits (603), Expect = 1e-60, Method: Composition-based stats. Identities = 88/320 (27%), Positives = 149/320 (46%), Gaps = 22/320 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 +LS+ G++ NP ++S +G + +A D G G V KT+ +P Sbjct: 1 MVELSVEVAGLRLRNPVVVASGVLGVSVGLMKRAEDAGAGAVTSKTVTLNPREGYPNPVV 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L +G N P E + + R +IASI + +A Sbjct: 61 YELDYGLVNSMGLPN-------PGAEEMGRILREARRVLGIPVIASIGASTPDEALRIAE 113 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ G D +E N SCP + +G+D+ P+ V A+K + K++P+ GD Sbjct: 114 ALE--GFDALELNASCPHVKG--LGADLMSDPDAVYGIVSALKSSGYR-VFLKLSPH-GD 167 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 VA A G DG AINT K++ ID+ + + +A+ PIA+R Sbjct: 168 YLAVARKAYSAGVDGFTAINTAKAMV-IDVYARKPVLGGVVGGLSG----RAIHPIAVRV 222 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + ++ H E + P+ G GG+E W +A E +L GA+ + V T + + G+ ++ ++ G+ Sbjct: 223 VYEL--HREFPEVPVIGTGGVEGWVEAVELILAGASAVGVGTAL-KRGFEVIGEILGGIE 279 Query: 302 HYLADQGFDSLQEMVGLANN 321 YL D+GF S++ +VGLA+ Sbjct: 280 RYLRDEGFPSVESIVGLAHK 299 >UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organisms RepID=Q7PYN9_ANOGA Length = 404 Score = 236 bits (603), Expect = 1e-60, Method: Composition-based stats. Identities = 72/334 (21%), Positives = 124/334 (37%), Gaps = 25/334 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 T L G+ F NP +++ + E G+G V ++ PR Sbjct: 81 TDRLRTRLLGMAFSNPIGIAAGFDKHG-EAVQGLQLIGFGFVEIGSVTPEPQPGNARPRI 139 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEE 118 L ED + + E L R ++ +V + +G+N+ + Sbjct: 140 FRL-NEDKAIVNRYGFNSEGHDVVYERLRECRE-QQPPDQRVALGINLGKNKLSLDAIAD 197 Query: 119 LARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPMLA 173 + V+ G AD + N S P L+ + +A + P+L Sbjct: 198 YVQGVKRFGTLADYLVINVSSPNTPGLRTMQSKSTLQTLLTEVLKARASLPANEQRPILL 257 Query: 174 KMTPNIG--DMCEVA--LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ D+ E+ + AK DG+ NT + G Sbjct: 258 KLAPDLSEEDLREIVDVVRAKACAVDGLIVSNTTIDRP--------ATLRSVNAGQLGGL 309 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG +K + I ++ E + PI G+GGI T EDA E + GA+ +Q+ T + +G Sbjct: 310 SGPPLKHRSTAMIARVYKLTEGK-IPIIGVGGIFTGEDAFEKIEAGASAVQLYTSFIFHG 368 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 +V + L L G+ S+Q+ VG + Sbjct: 369 PPVVPKIKRELDRLLEANGYASVQDAVGKGVDKY 402 >UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLU5_9BACT Length = 302 Score = 236 bits (602), Expect = 1e-60, Method: Composition-based stats. Identities = 78/317 (24%), Positives = 148/317 (46%), Gaps = 26/317 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DL++ +KF NP ++ P E +A + G GG+V KT+ A P Sbjct: 1 MADLTVKLGKLKFINPVLPAAGPNVMRLEQMLEAVERGAGGIVTKTVSREPAVYPKPCIS 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + G N E ++ P + ++KE LI SI G + + EL + Sbjct: 61 KGPCD-----GLLNCETWSDRPWRSYIDDYVKVKET--GVPLICSI-GYSPEDVAELGKA 112 Query: 123 VQ-EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ E G D++E VG++ + +++ A++ + P+ K++P+ + Sbjct: 113 LEAEVGPDVVEF-----------STHYVGKTLDPLKRVAEALRGSVSCPVWMKVSPSTPN 161 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+A DG A+N+V + D+++ P + + SG A+ +AL Sbjct: 162 IPEMAK-VMSDYVDGFVAVNSVGPALDFDIDKP--KPRLGTEDGHGWLSGPAITGVALYA 218 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q+ +D P+ G+GGI T EDA +F++ GA+ + + + ++ G I +AS +S Sbjct: 219 VYQISHS---QDKPVVGVGGIRTGEDAVKFIMAGASLVGICSEAIRRGTGIYGKIASEIS 275 Query: 302 HYLADQGFDSLQEMVGL 318 ++ +G+ SL ++ GL Sbjct: 276 DWMDRKGYGSLDDIRGL 292 >UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacteria RepID=Q47C62_DECAR Length = 336 Score = 235 bits (599), Expect = 2e-60, Method: Composition-based stats. Identities = 79/343 (23%), Positives = 146/343 (42%), Gaps = 27/343 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA---NEVSP 59 DLS T+ G+ NP SS+P+ + + D G +V ++ ++ Sbjct: 1 MPDLSTTYLGLSLKNPLVPSSTPLSHDLDAVLHLEDAGAAAIVMHSLFEEDVRHDEQMID 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 RF G + L+ L ++RLK ++AS+ G + W EL Sbjct: 61 RFLVHPDTFGEATGHLPFGHDYQSRLDSYLEQIQRLKSRL-AIPVVASLNGSSLSGWVEL 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK----YCRAVKRGSTLPMLAKM 175 + +Q AGAD +E N + M SD S E +E + +K ++P+ K+ Sbjct: 120 GKEMQGAGADALELN-------AWYMPSDPKISCEAIEDHHVSLLQELKTVVSIPVSMKL 172 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 +P + + GA GI+ N +IDL + V S A Sbjct: 173 SPFFSSLPHFVHQIEMAGAAGISLFNRFFQ-PDIDLETLSVVDRVQ-------LSSSADT 224 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 +A+R+I +R +L ++ GG+ T EDA + LL GA + + +++ G + + + Sbjct: 225 LLAMRWIAILRGSTKLS---LAATGGVHTAEDALKMLLAGADVAHMASALLKRGPQALGE 281 Query: 296 MASGLSHYLADQGFDSLQEMVG-LANNNIVPAEDLDRSYIVYP 337 + + ++H+L + + S+ +M G ++ N D R+ ++ Sbjct: 282 VLAAMTHWLDEHEYSSVAQMKGSMSQQNSPNPSDFARAAYLHA 324 >UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8W8_WEIPA Length = 323 Score = 234 bits (598), Expect = 3e-60, Method: Composition-based stats. Identities = 76/330 (23%), Positives = 139/330 (42%), Gaps = 19/330 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 M + +++ G+K NPF SS + G +V KT P Sbjct: 1 MNDERYAVSLPGLKLKNPFMPSSGAFYYGLDHMDDFDLNKLGALVLKTTTLAPRTGNPQP 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 +V G + + ++ + L L PD + SI G ++ +L Sbjct: 61 W---IVNTKAGILNSVGLANPGIAAVKADF--LPELAAKLPDLPKMLSISGATVDEFVQL 115 Query: 120 ARLVQEAGA-DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A+++ + A + IE N SCP + G G + + AV+ +T + AK++PN Sbjct: 116 AKIIDKLPAINAIELNLSCPNVDEG--GCAFGVTESGIHSVVSAVRAVTTKAIYAKLSPN 173 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ +A+ A+ GADG+ +NT+ ++ +DL + G SG+A+ P+A Sbjct: 174 VTDIKPLAVTAENAGADGLTMVNTLVGMS-LDLQSRSAR----LYRGKGGLSGEALHPLA 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 + I + + PI G+GG+ + +DA E ++ GA+ +QV + + + Sbjct: 229 VELIWEAASAVH---IPIIGVGGVSSIDDALELMMAGASAVQVG-VMNSIDKLCLPKLID 284 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAED 328 L L FD + ++ A + E Sbjct: 285 ALPAALDKYHFDKVSDVTN-ALRALPENEH 313 >UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Staphylothermus marinus F1 RepID=A3DM44_STAMF Length = 301 Score = 233 bits (595), Expect = 8e-60, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 133/319 (41%), Gaps = 18/319 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL+ G+ F +P +S + + TG G+V KT+ P Sbjct: 1 MDLTTKVTGIVFKHPIMNASGILASSINGVGILAKTGVAGIVTKTLTLKPREGYLPPI-- 58 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 + D G + + + + + + I SI G + ++++ LA Sbjct: 59 TIPLDYGLLNAVGLANPGIDAVNVLVEEIHKY-----GLPAIVSIGGRDPREFQILAEKA 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 +A + +E N SCP G D + E+++ V S +P+ K+ + Sbjct: 114 LDARPEALELNLSCPHTPG--FGVDTVATDEVLKHVALNVSSVSNIPVWGKLG-FSRRII 170 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 + G D + INT+ + ++ +G P++ G SG A+ P+A+ + Sbjct: 171 RESEILLNNGVDAVVLINTLPGMF---IDVYVGKPVL--THGFGGLSGPAIHPVAVYSVY 225 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ I G+GG+ W+ + E LL GA +Q+ TG GY IV ++ G+ Y Sbjct: 226 KVYEELGAE---IIGVGGVIDWKTSVELLLAGAKAIQIGTGFYMVGYNIVNNILDGIKKY 282 Query: 304 LADQGFDSLQEMVGLANNN 322 + ++GF + +++G A+ Sbjct: 283 MEEKGFTRISDIIGYAHRK 301 >UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G037_9DELT Length = 334 Score = 233 bits (594), Expect = 1e-59, Method: Composition-based stats. Identities = 83/319 (26%), Positives = 143/319 (44%), Gaps = 21/319 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 + +L+ F +K +P +S + GG+ K I + Sbjct: 15 SVELACDFGPLKLRSPILTASGCFAYGQQFAEFMDLRQIGGLSTKGISPLPRHGNP--LP 72 Query: 63 HLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + +G I +E + E L E L L L D + + G + + + + A+ Sbjct: 73 RIYETASGMINSIGLENVGCEAFLTEKLPFLADL-----DVSVWVNFFGTDFETYVDCAK 127 Query: 122 LVQEAG---ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 + E G D++E N SCP + G + G PE+ + +A S +P++ K+TPN Sbjct: 128 TLSEGGEGRIDVLEMNISCPNIKKG--GIEFGTVPEVAHRLTKACVEASEVPIVVKLTPN 185 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ +A A K GA G++ INT+ ++ ID+ + ++ G SG A+KP+A Sbjct: 186 VSDIVAMAQAVKEAGAIGVSLINTITAMA-IDVRSRRSRI----ATTYGGLSGPAIKPVA 240 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR + Q+ L FPI G+GGI T ED E+ + GA +Q+ T + Sbjct: 241 LRMVHQVAKA--LPGFPICGMGGILTGEDVLEYFIAGAHCVQLGTINFSE-PGAALRVTR 297 Query: 299 GLSHYLADQGFDSLQEMVG 317 L +A+ G + +Q+ V Sbjct: 298 ELRELMAELGIERVQDAVA 316 >UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteobacteria RepID=Q1MQG1_LAWIP Length = 314 Score = 233 bits (593), Expect = 1e-59, Method: Composition-based stats. Identities = 82/311 (26%), Positives = 135/311 (43%), Gaps = 21/311 (6%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDTGF 71 + NP +S G E + GG++ K + PR Sbjct: 20 LVLKNPVLTASGTFGYGAEFIGYGDLSQLGGIIVKGLSLKPRKGNPLPRIAETPCGMLNT 79 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL-ARLVQEAGADM 130 IG +N E +++ L L + +IA++ + +++ EL A L E G Sbjct: 80 IGLQNDG--VELFIQKKLPRLPW-----KETPVIANLYATSVEEFSELTAILAAEEGVAA 132 Query: 131 IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-KRGSTLPMLAKMTPNIGDMCEVALAA 189 +E N SCP + S GQ P L K AV K + P++ K++PN+ D+ +A A Sbjct: 133 LEVNVSCPNVKSGGTF--FGQDPSLAAKVTEAVCKNAGSKPVMVKLSPNVTDITIIAKAV 190 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 + GAD I+ INT+ + +D+ ++ + + I G SG +KPIALR + ++ Sbjct: 191 ESAGADAISCINTLTGMA-VDIRKRKSL----LSTVIGGLSGPGIKPIALRCVWEV---C 242 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 + + P+ GIGGI + D EF+L+GA +Q+ T I +A L + G Sbjct: 243 KAVNIPVIGIGGITSARDVLEFILVGAHAVQIGTMNFIQ-PDIAFRIAEALPIICNELGI 301 Query: 310 DSLQEMVGLAN 320 + G Sbjct: 302 KNFDSFRGSLQ 312 >UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota RepID=Q75XR0_EUGGR Length = 435 Score = 231 bits (590), Expect = 3e-59, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 129/342 (37%), Gaps = 36/342 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DL + G+KF NP L++ + E TG+G V T+ SPR Sbjct: 95 PADLEMEVWGLKFSNPLGLAAGFDKHG-EAVDALLGTGFGFVEIGTVTPLPQPGNPSPRM 153 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEE 118 L ++D I + + L A R P L+ +G+N+ + Sbjct: 154 FRL-EQDRAIINRYGFNSQGLAAVRKRLEA--RQHRPAPRGGLVGVNVGKNKLQEDAAAD 210 Query: 119 LARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVE-------KYCR-------- 161 ++ ++E G AD + N S P +L++ + R Sbjct: 211 YSKGLRELGPYADYLVINVSSPNTPGLRNLQKRSAMADLIKASMVARDEVVRDADGRRAA 270 Query: 162 AVKRGSTLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 A K + LP+L K+ P++ + ++A DG+ NT S + Sbjct: 271 AGKSAAPLPLLIKIAPDLTAEEKQDIAEVVMETKIDGLIVSNTTVSRP--------ASLL 322 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 K G SG ++ ++ + I+ M PI G+GG+ T ED E L GA+ + Sbjct: 323 SPHKGQTGGLSGAPLREMSTQAIRDMYALTRGT-VPIVGVGGVATGEDVLEKLKAGASLV 381 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 Q+ + ++ G + GL L + F S + VG + Sbjct: 382 QMYSMLVYDGPGAPPRVKKGLLQALRREHFGSARSAVGADHR 423 >UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfurococcales RepID=PYRD_AERPE Length = 306 Score = 231 bits (589), Expect = 4e-59, Method: Composition-based stats. Identities = 85/321 (26%), Positives = 142/321 (44%), Gaps = 17/321 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 +LSI+ G++ P +S +G + G G V K++ + Sbjct: 3 SQPELSISIAGLRLQRPVGNASGILGWEPREARLVEEGGGGFFVAKSVTYQPRKGYPQ-- 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 HL G + + + LA + +IASI G +W E+A Sbjct: 61 PHLYPVAGGIVNAVGLANPGFREASKMLAQ----TVEEASIPVIASIAGGAPGEWVEMAS 116 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++EAG +E N SCP G ++GQ P V AV +P++AK+ Sbjct: 117 TLEEAGVSAVELNLSCPHFAGG--GLELGQDPAAVASVVSAVASTLRIPVIAKLG-YSDR 173 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + + A A GA G+ IN+++++ ++ P++ + + G SGK + PIA+R Sbjct: 174 LVDAASKALEAGARGLTLINSMRAM---KIDVYAKKPVLGNR--VGGLSGKPIHPIAVRA 228 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + ++ I GG+E+WEDA EF L GA +QV + G ++ + G+ Sbjct: 229 VYEVYGETRAD---IFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIVEGVR 285 Query: 302 HYLADQGFDSLQEMVGLANNN 322 YL +GF SLQ++VG A+ Sbjct: 286 RYLWVEGFRSLQDIVGYAHRA 306 >UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZTF1_OPITP Length = 332 Score = 231 bits (588), Expect = 4e-59, Method: Composition-based stats. Identities = 60/339 (17%), Positives = 134/339 (39%), Gaps = 20/339 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF----IANEV 57 + +L+ T+ G+ NP + +SP + E + + G +V +++ + Sbjct: 1 MQLNLATTYLGLPLRNPLIVGASPFSDDLEAARQLQEAGAAALVMRSLFEEQIDLEQRAL 60 Query: 58 SPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 + + L + F + + L + L + D +IAS+ G + W Sbjct: 61 NRDLEALTESFAEASSFFPEYGEYQLTPDRYLRQIELLTSEL-DIPIIASLNGRHPGGWL 119 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + AR + AGAD IE NF G ++ + + + R+V +P+ K++P Sbjct: 120 DYARKFEAAGADAIELNFYQLVTDPKVSGDEIE---DELIETLRSVVTAVRIPVAVKLSP 176 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + A ++ GA G+ N + + D++ P + S + Sbjct: 177 FHTSLPHFTQALRQAGAAGLVLFNRLYQ-PDFDVDALEVQPTLR-------LSDPGELLL 228 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 LR++ + + ++ GG+ + D A+ +L GA +Q+ + +++ G +++ + Sbjct: 229 RLRWLAILSPNHLGS---LAASGGVHSGTDVAKAVLAGADAVQIVSAVLRQGPAVLKTLL 285 Query: 298 SGLSHYLADQGFDSLQEMVGLAN-NNIVPAEDLDRSYIV 335 ++ + + E G N + L+R+ Sbjct: 286 QDFETWMRTHEYTHVGEFRGGLNLRHCPDPAALERANYQ 324 >UniRef50_A8RT96 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RT96_9CLOT Length = 361 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 91/367 (24%), Positives = 149/367 (40%), Gaps = 36/367 (9%) Query: 33 CAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHP-LEENLAA 91 K ++ G G VV KTI A H+ N E+ A+ L Sbjct: 1 MIKGHEAGAGAVVTKTIRLGAAINP---VHHM--GTVNQDSLINCEKWADSDRLNWYENE 55 Query: 92 LRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQ 151 + K V+I S+ G ++ + + + V+ AGA MIE V Sbjct: 56 IP--KTVAAGAVVIGSV-GHTLKEAQAIVKDVERAGAHMIEL---------------VSY 97 Query: 152 SPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDL 211 + + + K +P++ K++ N D A GA+GI AI+++ ID+ Sbjct: 98 TEDTLLPMLDYTKEHVDIPVICKLSGNWPDTAATARRCLEHGANGICAIDSIGPTLKIDI 157 Query: 212 NQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEF 271 + P + +G A++PIA+R+ Q+ + + GG+ +DA E+ Sbjct: 158 EK--AAPEMMSGDGFGWMTGAAMRPIAMRYNYQIAKENP-QLMNLYASGGVMKADDAIEY 214 Query: 272 LLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331 ++ GA + V T + G VE M LS LA+ G+ S+QE+ A+ N E + Sbjct: 215 MMAGAMGVGVCTAGILKGVEYVEKMCYDLSKRLAELGYSSIQEVNRAAHPNFPSEEHISG 274 Query: 332 SYIVYPRINLD----KCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHV 387 + D KCV C +C C + + + E T + +KC C LC V Sbjct: 275 LKFHFTPFKEDGTTKKCVSCKKCETVCCYDA-RKLTFPEMT----VDMDKCRCCGLCLDV 329 Query: 388 CPVGCIE 394 CP G + Sbjct: 330 CPTGALT 336 >UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanobacteria RepID=A8ZNQ0_ACAM1 Length = 339 Score = 230 bits (587), Expect = 7e-59, Method: Composition-based stats. Identities = 62/344 (18%), Positives = 127/344 (36%), Gaps = 21/344 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSS-PVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS T+ G + +P + + P+ + D G +V ++ + F Sbjct: 1 MDLSTTYLGTRLRSPLVVGACAPLSEKIDHLRHMEDAGAAAIVLHSLFEEQLRQDRLGFH 60 Query: 63 HLVKEDTG----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 H + T + + + E+ L + + K D +IAS+ G W Sbjct: 61 HHLTHGTESFAEALSYCPEPDVFHVGPEQYLEHIHQAKA-IVDTPIIASLNGATIGGWTN 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A+ ++EAGAD +E N G+++ QS V +P+ K++P Sbjct: 120 YAKKIEEAGADALELNIYTVPTEMAIAGAEIEQSY---IDIVHTVTSTVNIPVAIKLSPF 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 ++ +A G +G+ N +ID+ P + S + Sbjct: 177 FSNLAYMAKRLTDAGVNGLVLFNRFYQ-PDIDIETLEVRPNLL-------LSTPQDIRLP 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR+I + + GI T D + +++GA + + ++++G + + Sbjct: 229 LRWIAILY---GTLPVDFAATSGIHTAADVLKMMMVGANATMLVSVLIRHGIDHLRTLEH 285 Query: 299 GLSHYLADQGFDSLQEMVGLANN-NIVPAEDLDRSYIVYPRINL 341 L +L + ++S+Q++ G + N +R + Sbjct: 286 ALCQWLKEHEYESIQQLQGSMSQVNCPDPSAFERVQYIEALQTY 329 >UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=C0Z506_BREBN Length = 363 Score = 229 bits (585), Expect = 1e-58, Method: Composition-based stats. Identities = 76/334 (22%), Positives = 130/334 (38%), Gaps = 40/334 (11%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFD 62 + L G+ FPNP L++ N E+ G+G V T+ PR Sbjct: 47 QRLENKLWGMTFPNPVGLAAGFDKN-AEVYHALGALGFGFVEIGTLTPQGQPGNPKPRLF 105 Query: 63 HLVKEDT--GFIGFKNMEQI--AEHPLEENLAALRRLKEDYPDKVLIASI-MGENEQQWE 117 L + +GF N ++H ++ D P + I + NE+ Sbjct: 106 RLPEHQAVINRMGFNNHGAYLASQHLVDYAY-------SDVPIGINIGKNKVTPNEEAAV 158 Query: 118 ELARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST------- 168 + ++ + A N S P + + E + RAVK +T Sbjct: 159 DYSKCMDMLYAYGHYFVINISSPNTPNLRDLQE----TESLRHLVRAVKEKATEMEGRSI 214 Query: 169 --LPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 P+L K+ P++ D M +V AA G GI A NT S + ++ Sbjct: 215 KKKPILLKVAPDMSDEHMRDVVHAAVEEGISGIIATNTTLSREAVSGHRF--------AE 266 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG+ + + +++++ + PI G+GGI EDA + GA+ +QV TG Sbjct: 267 EAGGLSGRPLTERSTAWVKEIYQEVGDK-VPIIGVGGIYNGEDAYAKIRAGASLVQVYTG 325 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 ++ G I + + L + GF + E++G+ Sbjct: 326 MIYQGPGIAKQINKKLLKLMQRDGFKHISEVIGV 359 >UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E0W2_METI4 Length = 344 Score = 229 bits (584), Expect = 1e-58, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 146/341 (42%), Gaps = 20/341 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 ++ L T+ G+K +P S+SP+ + + G G VV ++ + + Sbjct: 1 MSTSLETTYLGLKLSSPLVPSASPLSKSIDTVKALEEMGAGAVVLYSLFEEDIEKEALHL 60 Query: 62 DHLVKEDTG----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 + V T + + + + L LRRLKE +IAS+ ++ QW Sbjct: 61 ERSVTMGTESFAEALSYVPEVPGLKMGPDYYLDHLRRLKESVSI-PIIASLNAQSPGQWV 119 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + A+L++EAGAD +E N +++ Q + A ++ +LP+ K++P Sbjct: 120 KYAKLIEEAGADALELNLYSIPTQESLSSTELEQ---RYLEIVSACRQSVSLPIAVKLSP 176 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + ++ G+ N +IDL P + + G+ + I Sbjct: 177 FFTNFFSFSSRVEKTAVQGLVLFNRFFQ-PDIDLENMTVEPRITLSTE-----GELLLRI 230 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 +I + +L +S GGI + D + LL GA T+Q+ + ++ +G ++ + Sbjct: 231 T--WIGILYNRVKLD---LSATGGILSSTDVLKALLSGATTVQLCSALLYHGVEYLKTVK 285 Query: 298 SGLSHYLADQGFDSLQEMVGLA-NNNIVPAEDLDRSYIVYP 337 +G+ +L ++G+ S+ E+ GL N +R+ VY Sbjct: 286 NGVVEWLEEKGYRSINEIRGLLSQKNCPDPSSYERAQYVYA 326 >UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria RepID=B8G4M8_CHLAD Length = 355 Score = 229 bits (584), Expect = 2e-58, Method: Composition-based stats. Identities = 64/325 (19%), Positives = 128/325 (39%), Gaps = 20/325 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS T+ G+K P ++SP+ E+ + + G G VV ++ + S D + Sbjct: 3 DLSTTYLGMKLRTPIVAAASPISRNVELVRQLEEAGLGAVVMYSLFEEQIIQQSLELDRM 62 Query: 65 ----VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + + + E L + LK+ +I S+ G ++ W A Sbjct: 63 LSHGAESFAEALSYLPEHGAYSTGPERYLEQVAALKQGLSI-PVIGSLNGVSKGGWVHYA 121 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 RL+QEAGAD +E N + ++ S++ ++ +AV+ ++P+ K+ P Sbjct: 122 RLIQEAGADALELNIYFVPIDTNITSSELE---DIYVDLVKAVRAEISIPLAVKIGPYFT 178 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + A GA+ + N + DL Q P + S A ++LR Sbjct: 179 ALPNFAWRLMEAGANALVLFNRFYQ-PDFDLEQLSVRPNLQ-------LSTSAELRLSLR 230 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ-YGYRIVEDMASG 299 +I + L G+ D + L+ GA + + ++ ++ + Sbjct: 231 WIALLYGRIPLEFAL---SSGVHNAIDVLKGLMAGANVTMIASAFLRGRATDVLRTILHD 287 Query: 300 LSHYLADQGFDSLQEMVGLANNNIV 324 + +L + ++S+ ++ G + V Sbjct: 288 MELWLTEHEYESIAQLHGSMSQRAV 312 >UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer subunit/dihydroorotate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JFH0_9ARCH Length = 589 Score = 229 bits (583), Expect = 2e-58, Method: Composition-based stats. Identities = 82/323 (25%), Positives = 146/323 (45%), Gaps = 22/323 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 +L+ CG+ F NP ++ G ++ + G G VV K++G + +P F Sbjct: 286 EPELATEVCGIIFTNPIANAAG-FGLSGKLLYRYAVAGAGAVVTKSVGLYEQEGYPNPTF 344 Query: 62 DHL-VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + + +G N I ++ LE A Y D LI SI G+N ++ E+A Sbjct: 345 IEIAPRSYVNAMGLPNPGII-DYGLEIGDAK-------YADVPLILSIFGKNVEECREVA 396 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-LPMLAKMTPNI 179 ++ + DM+E N SCP V P+L+ + ++ P+ K++PN+ Sbjct: 397 KIATKYPIDMLEFNASCPHSD----FVAVENQPKLLRSIIKEIRAIVHPKPIAVKISPNV 452 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 GD +A+ ++ GAD I AINTV + ++ ++ I+ + G SGK + Sbjct: 453 GDPAGLAMTLEKAGADAITAINTVIARP---VDNRLDTHILGNPTGYGGKSGKDLTVGGK 509 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + + + PI +GGI + +D ++ GA+ QV + ++ I + Sbjct: 510 EIVFNLYKELK---IPIIAVGGIFSAKDVIDYAKNGASMFQVGSALVSEDLEIFSTIKKE 566 Query: 300 LSHYLADQGFDSLQEMVGLANNN 322 L YL +G+ ++ EMVG A+ Sbjct: 567 LKAYLGAKGYKNIGEMVGEAHRR 589 >UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F860_9ACTN Length = 307 Score = 229 bits (583), Expect = 2e-58, Method: Composition-based stats. Identities = 78/321 (24%), Positives = 131/321 (40%), Gaps = 20/321 (6%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSP 59 M ++++ F GVK NP +S G ++ + G + K +P Sbjct: 1 MSQVNMAVDFGGVKMKNPINTASGTFGYGWQFSELMDVSQLGAITTKGCAAEAWPGNPAP 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R + +G +N A E++ L L +I + G + +++ Sbjct: 61 RMAEVPGGMMNSVGLQNPGVAA--FAEQSGPWLADL--TAKGTQVICQVAGHSTEEYVRA 116 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + E A E N SCP + + G+ G +PE + RA ++ + P+ KM P Sbjct: 117 LEMFVELCPWAAGYEINVSCPNIAAG--GAACGSTPEGASEVMRACRKVTDKPLFVKMAP 174 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + E+A A + GADG+ IN++ ++ ID+ + G SG PI Sbjct: 175 --VRIPEIARALEAEGADGLTVINSIPGMS-IDVRTRRSR----LSKPTGGLSGPLCHPI 227 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 A+R + + D PI G+GG+ T EDAAEF+L GA + V + Sbjct: 228 AVRMVWEAANAV---DIPICGVGGVMTGEDAAEFILAGACCVSVGMANFVE-PDASVRIL 283 Query: 298 SGLSHYLADQGFDSLQEMVGL 318 L + QG + E++G Sbjct: 284 HELEAWAESQGVKDINELIGA 304 >UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 Tax=Proteobacteria RepID=Q0B324_BURCM Length = 325 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 83/337 (24%), Positives = 142/337 (42%), Gaps = 21/337 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DLS+ ++ NP +S E TG G +V K++ +PR Sbjct: 1 MADLSVRVGELRLRNPVMPASGCF--AIEYRDALDLTGLGALVIKSVSPVSRPGNPTPRV 58 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 D G G N I +++ L + + ++AS+ + + Sbjct: 59 A-----DAGD-GMLNSIGIPSRGIDDYLEHVLPAYTGH-GTPVVASVSADTADAFARACE 111 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + IE N SCP + + M G + + A++ + P+ K+TPN G+ Sbjct: 112 ALSRPDVAAIEANISCPNLEADGM--AFGMDAGMTRQVVDAIRTRTGHPLWVKLTPNAGN 169 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + ++A AA+ GAD I NTV ++ ++ + P + + + G SG ++KPIALR Sbjct: 170 IAKIAQAAQDAGADAIVMGNTVLGMS---IDVRTRRPSLG--NVMGGLSGPSIKPIALRL 224 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q P+ G GGI + DA EFLL GA+ +QV T + ++ + GL Sbjct: 225 VHQCYRAV---SIPVIGCGGIRSAADAIEFLLAGASAVQVGTASFR-DPGVMRTIIDGLE 280 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPR 338 + AD+G ++ + G + +E R R Sbjct: 281 QFCADEGIGAIASLTGQVRLDAELSERWQRFCAAPAR 317 >UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycetales RepID=A1UMT4_MYCSK Length = 340 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 79/340 (23%), Positives = 130/340 (38%), Gaps = 33/340 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS + G++ NP ++SP+ + + D G G VV ++ + Sbjct: 1 MDLSTRYLGLELRNPLLAAASPLSRTLDGVKQLADAGVGAVVLYSLFEE-------QLRR 53 Query: 64 LVKEDTGFIGFKN---MEQIAEHP--------LEENLAALRRLKEDYPDKVLIASIMGEN 112 ++ F N E + P +L L R + + +I S+ G Sbjct: 54 EAADNARMATFANETHAESVTYFPSTVGEGDGARRHLRLLERAAAEV-EVPVIGSLNGST 112 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 W AR +++AGA IE N SH G +V Q AVK LP+ Sbjct: 113 PGGWVRHARAMEDAGAAAIELNIYQLPGDSHISGREVEQRH---LDILAAVKDTVDLPVA 169 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 K++P E+AL + GADG+ N +ID V S Sbjct: 170 VKLSPFFSATAEMALRLDQAGADGLVLFNRFLQ-PDIDSETISVTSEVT-------LSVP 221 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 A + +I +R D ++ G+E D A++LL GA +Q + ++++G Sbjct: 222 AEARLPRTWIALLRGRI---DASLAATTGVEDAGDVAKYLLAGADVVQTASALLRHGPEY 278 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRS 332 + +GLS +LA + F +L ++ G E Sbjct: 279 AGVLLTGLSDWLARKSFHALHQVRGKLAVPFGVDETARER 318 >UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteriaceae RepID=D2S350_9EURY Length = 356 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 73/324 (22%), Positives = 126/324 (38%), Gaps = 26/324 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 L + FPNP +++ N E+ G+G V T+ + PR Sbjct: 48 HPALEVDLFDSTFPNPVGIAAGFDKN-AEVTHALEALGFGFVEIGTVTPYPQEGNDRPRL 106 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-WEELA 120 L +ED G I ++E L +P V I + E++ E+ Sbjct: 107 FRL-REDEGMINRMGFNGQGMETVKERLEE--DGTPGFPLGVNIGKMNSSTEREAIEDYR 163 Query: 121 RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG--STLPMLAKMT 176 R+ AD + N SCP SPE + ++ +PML K+ Sbjct: 164 RVFDRVSPFADYVVVNVSCPNTPDEFN----EASPEHLRAIFETLEAENDGNVPMLVKIG 219 Query: 177 PNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P+ + + ++ + G DGI A NT + ++ + G SG + Sbjct: 220 PDEPEDAILDLVDIVQEFGLDGIVATNTSTAREGLE---------SPAREEWGGLSGAPI 270 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + + I+ + H + + PI G+GG+++ A E + GA+ +Q+ TG + G Sbjct: 271 EDRSTDVIRTIAGHTD-GELPIVGVGGVDSAASAYEKIRAGASLVQLYTGFVYRGPSTAG 329 Query: 295 DMASGLSHYLADQGFDSLQEMVGL 318 + GL L GF S+++ VG Sbjct: 330 RINQGLVDLLERDGFSSVEDAVGA 353 >UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular organisms RepID=PYRD_BRASB Length = 364 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 75/336 (22%), Positives = 133/336 (39%), Gaps = 32/336 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L++ G+ FPNP +++ N E+ G+G V ++ PR L Sbjct: 44 LAVRAFGLNFPNPVGMAAGFDKN-AEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLFRL 102 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW---EEL 119 +++ +GF N + LRRL ++ +G N+ + Sbjct: 103 ERDEAVVNRMGFNN---------DGAEIVLRRLAGRANQGGIVGVNVGANKDSADRVADY 153 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV----KRGSTLPMLA 173 RL++ A N S P Q EL+ K A ++ P+L Sbjct: 154 VRLIETFAPVASYFTVNISSPNTPGLRNLQQAAQLNELLSKVLEARDRVRRKAGDTPVLL 213 Query: 174 KMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P++ ++ +V A+ G DG+ NT + N Q G SG Sbjct: 214 KIAPDLSLAELDDVVHVARSRGVDGMIVSNTTLARPNSLREQLRAK-------EQGGLSG 266 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + + ++ R + + E FP+ G+GGI++ A + GA+ +Q+ + ++ G Sbjct: 267 RPLFRLSTRMVAETFVRVE-GAFPLIGVGGIDSGGAALTKIRAGASLIQLYSSLVYKGLG 325 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 +VE + + L+ L G DSL E+VG I + Sbjct: 326 LVESIKADLTSTLLRTGRDSLSEIVGADAATITAED 361 >UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 Tax=Bacteria RepID=A6L9F5_PARD8 Length = 325 Score = 227 bits (579), Expect = 5e-58, Method: Composition-based stats. Identities = 70/340 (20%), Positives = 138/340 (40%), Gaps = 19/340 (5%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 D+ + G+ NP + SS + N E G G +V K++ ++ + + L Sbjct: 3 DIKTQYAGLTLRNPIIVGSSGLTNKAERNRDFEKAGAGAIVLKSL---FEEQIEMQSEAL 59 Query: 65 VKEDTGFIGFKNMEQIAE-HPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 +++ + + + + + L +++ KE +IASI W + AR + Sbjct: 60 MQDSDYPEAADYIRGYVKANQVNDYLELIKKSKE-LCTIPIIASINCYKADAWIDFARQI 118 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + AGAD +E N + D + R VK ++P++ K+ N ++ Sbjct: 119 ELAGADALELNVF---FMETELTEDFESIRDTYVSIIRKVKETVSIPVIMKIGKNYSNIP 175 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 + K GADG+ N +ID+N + + S +S +R+ Sbjct: 176 SLVNLLKVNGADGVVLFNRFYQ-PDIDINNMQ----IVSGNVFSNHS---DLSDTIRWTA 227 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + ++ I+ G+ WED + LL GA+ +Q+ + + +G I+ + + + + Sbjct: 228 IVS--GKIPGISIASSTGVHDWEDVVKCLLAGASAVQMCSAVYTHGAEIISQVLTCVEEW 285 Query: 304 LADQGFDSLQEMVGLANN-NIVPAEDLDRSYIVYPRINLD 342 + + SL + G N NI +RS + N D Sbjct: 286 MHQAHYQSLSQFQGKLNYANIPNPAMYERSQFMKYFSNRD 325 >UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q682_MALGO Length = 665 Score = 227 bits (579), Expect = 5e-58, Method: Composition-based stats. Identities = 80/384 (20%), Positives = 130/384 (33%), Gaps = 71/384 (18%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G NP L++ E +D G+G V +I +PR L Sbjct: 115 LRTELFGKTLTNPIGLAAGFDKQG-EAIDGLFDLGFGLVEIGSITPEPQPGNPTPRMFRL 173 Query: 65 VKEDT--GFIGFKNMEQIAEHP-----LEENLAAL------------------------- 92 + +GF + A L + + + Sbjct: 174 PLDAAVINRMGFNSEGHEAVRERLHARLHKWVQRVLSAGEGLVSSVGAPAPEPTALAEAQ 233 Query: 93 -------------------RRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGA--DMI 131 R LK+D + + E + + VQ GA DM+ Sbjct: 234 VFANYPVINTSLLDDAHVPRSLKQDRLLSINLGKNKSSREDSVVDYVKGVQALGAYADML 293 Query: 132 ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLPMLAKMTPNIGD--MCE 184 N S P ++ A + +LP++ K+ P++ D + + Sbjct: 294 VINVSSPNTPGLRRLQRRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELED 353 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 VA AA+ DGI NT S G+ G SG VKP+AL +Q Sbjct: 354 VADAARASKIDGIIVSNTTVSRP-------AGLLSTQHVHEAGGLSGPPVKPLALHALQV 406 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 + E + P+ G GGI T EDA EF GA+ +Q+ T + G + + L+ L Sbjct: 407 IYKRSEGK-IPLIGCGGIMTAEDALEFARAGASAVQLYTALAYRGPGLPRRIKDDLAARL 465 Query: 305 ADQGFDSLQEMVGLANNNIVPAED 328 +G + +++VG ++ Sbjct: 466 RAEG-KTWKDIVGSGLRDVPSYAP 488 >UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Culicini RepID=B0W4C3_CULQU Length = 397 Score = 226 bits (577), Expect = 9e-58, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 129/334 (38%), Gaps = 27/334 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 + L NP +++ + E G+G V ++ PR Sbjct: 77 PEVLRTQLLNKTLENPVGIAAGFDKHG-EAVKGLERLGFGFVEIGSVTPEPQPGNPKPRV 135 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEE 118 L ED + E +++L++D KV + +G N+ E+ Sbjct: 136 FRL-NEDKAIVNRYGFNS---EGHEVVFERIKKLRQDGDLKVTLGINLGRNKKSEDNIED 191 Query: 119 LARLVQE--AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPMLA 173 + +++ AD + N S P + L+ + +A + P+L Sbjct: 192 YVQGIRKFSVLADYLVVNISSPNTPGLRTMQNKSTLQSLLTEIVKARNALPPNEQRPILV 251 Query: 174 KMTPNIGDMCEVALAA----KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ D C + A K DG+ NT +++ + +N + G Sbjct: 252 KIAPDLSDGCVQEIIAVIQKKECAIDGLIVSNTT-------IDRPSELKSIN-AGQLGGL 303 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG + + + + ++ PI G+GGI + DA E +L GA+ +Q+ T ++ +G Sbjct: 304 SGAPLSSKSTQLVAKVYKWTG-GRVPIIGVGGIFSGRDAYEKILAGASAVQLYTALIYHG 362 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 IV + L L + G++++Q+ VG + Sbjct: 363 PPIVARVKEELGQLLKENGYENVQQAVGKGVDQF 396 >UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic subunit n=1 Tax=Oceanicola batsensis HTCC2597 RepID=A3U0T3_9RHOB Length = 314 Score = 226 bits (577), Expect = 1e-57, Method: Composition-based stats. Identities = 85/318 (26%), Positives = 143/318 (44%), Gaps = 23/318 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIANEVSPRF 61 DLS+T GV+ NP +S + E A D G G +V KTI + V P Sbjct: 1 MVDLSVTVGGVRMKNPVMPASG---SIAEGMADVVDLGRLGAIVLKTITPDLRQGVKP-- 55 Query: 62 DHLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 +V+ + + ++ L + + +IASI + + + +LA Sbjct: 56 PRVVEYTDATLFSIGIPSKGPDYLLNHTVPFFDKF-----GPPVIASISADTVEDFGKLA 110 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + + IE N SCP + +H G G P + A+K +TLP+ AK+TPN+G Sbjct: 111 GYITDPRIAAIEANISCPNLRAH--GRAFGMDPVASAQVITAMKANTTLPIWAKLTPNVG 168 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ E+A + GAD + N + + ++ + P + + + G +G AVKP+ LR Sbjct: 169 DIAEMARCVEGAGADAVITANAILGMA---IDAETMTPRLG--NVVGGLTGPAVKPVILR 223 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q E P+ G GGI T ED E++L GA+ +Q+ T + +E + Sbjct: 224 MVNQCA---EAVKIPVIGCGGIATGEDVVEYMLAGASAVQIGTTNFVH-TSAMEQSIDWV 279 Query: 301 SHYLADQGFDSLQEMVGL 318 + Y +G + ++ G Sbjct: 280 ADYCTRKGIARVSDLTGA 297 >UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular organisms RepID=PYRD_YEAST Length = 314 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 140/326 (42%), Gaps = 19/326 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-FFIANEVSPR 60 +T L+ F + NPF +S + + ++ G + K+ PR Sbjct: 1 MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIA-SIMGENEQQWEEL 119 + + +G N ++ L+ + +++YPD I S+ G + + L Sbjct: 61 YISVPLGSINSMGLPN------EGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNL 114 Query: 120 ARLVQEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R +Q++ + I E N SCP + V +L ++ V P+ K+ P Sbjct: 115 LRKIQDSEFNGITELNLSCPNVPGKP---QVAYDFDLTKETLEKVFAFFKKPLGVKLPPY 171 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITN---IDLNQKIGMPIVNGKSSISGYSGKAVK 235 D + AK +A +N++ SI N ID+ ++ +V K+ G G+ VK Sbjct: 172 F-DFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESV--VVKPKNGFGGIGGEYVK 228 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 P AL ++ T + + G GGI++ +DA E LL GA+ LQ+ T + + G +I E Sbjct: 229 PTALANVRAFYTRLR-PEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFER 287 Query: 296 MASGLSHYLADQGFDSLQEMVGLANN 321 + L + +G+ S+ + G N+ Sbjct: 288 IEKELKDIMEAKGYTSIDQFRGKLNS 313 >UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12 Tax=Chlorobiaceae RepID=Q3B2I1_PELLD Length = 331 Score = 226 bits (575), Expect = 2e-57, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 145/308 (47%), Gaps = 20/308 (6%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGF 71 G+ +P L+S V E+C + GG+V K I P+ + + +G Sbjct: 37 GLSLKSPVMLASGTVSYGEELCRLTDLSKIGGIVTKAISLEARAGNPPQ--RIAETPSGM 94 Query: 72 IGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA-GAD 129 I + + + + E + L+ L ++ +I G + ++ E+ + G D Sbjct: 95 INAIGLANVGIDRFISEKVPFLQTL-----GTAIVVNIAGRSIDEYAEVVSRLDAVPGLD 149 Query: 130 MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAA 189 E N SCP + M +G SP+ + ++ + ++ K+TPN+ + +A+AA Sbjct: 150 GYEINLSCPNVKGECM--IMGVSPDATREIVTELRSITGRHLMIKLTPNVTSISAIAIAA 207 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 ++ GAD ++ INT+ + ID ++ P++ K+ G SG A+KP+AL + ++ Sbjct: 208 EKAGADSVSLINTLVGMA-IDWKKR--RPLL--KNVTGGLSGPAIKPVALAKVWEV---N 259 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 PI G+GGI +++DA EFL+ GA +Q+ T I E +A+ + + G Sbjct: 260 NAVSIPIVGMGGIASFDDAMEFLVAGAGAVQIGTMNFVQ-PDIGEKIATAMEAFFCAPGA 318 Query: 310 DSLQEMVG 317 S++ G Sbjct: 319 PSMEAFRG 326 >UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae RepID=Q2S001_SALRD Length = 366 Score = 225 bits (574), Expect = 2e-57, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 124/331 (37%), Gaps = 27/331 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 + L G FPNP L++ N G+G V ++ +PR Sbjct: 45 ERLKQRLWGDTFPNPVGLAAGADKNAR-AVPFWEAVGFGFVEVGSVSAQPAPGNPTPRAF 103 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIAS-----IMGENE-QQW 116 L K D I + + + L R P + +A IMGE + + Sbjct: 104 RLPK-DQALINRLGLNNDGAEAVADRLEH-SRSDRARPLGINLAKTHDPDIMGEAALEDF 161 Query: 117 EELARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAK 174 R + G AD + N SCP D L+ K G +P+L K Sbjct: 162 RTSFRQL--VGQADYVTLNVSCPNTPDGGTFEDPAALDALLGAITAEQKAPGLAVPVLVK 219 Query: 175 MTPNIGD-------MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 ++P + D + E+ A DG A NT ++ + I Sbjct: 220 LSPPLSDRVLFDTRLEEILAVAADHDIDGFIATNTASDRKGVETSADRLDEI-----GAG 274 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG ++ A R +Q + + + PI G+GG+ E A + GA+ +Q+ T ++ Sbjct: 275 GLSGPPLEARATRLVQYLYRATD-GEIPIIGVGGVHDAESAYTKIRAGASLVQLYTALVY 333 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G +V + GL L+D G+ SL+ VG Sbjct: 334 EGPGLVRRIKEGLVARLSDDGYASLENAVGA 364 >UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 Tax=Actinomycetales RepID=A0LUF8_ACIC1 Length = 351 Score = 224 bits (572), Expect = 4e-57, Method: Composition-based stats. Identities = 93/332 (28%), Positives = 147/332 (44%), Gaps = 21/332 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DL+ V PNP +S E+ + G VV K+I A +PR Sbjct: 24 AVDLTTQLGSVVLPNPVTTASGCAAAGRELGQFVDVSTLGAVVTKSIMLAPRAGRPTPRM 83 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG + + LE +L L I SI G + ++ LA Sbjct: 84 AETPSGLLNGIGLQGPGI--DEFLEHDLPWLAEHGARA-----IVSIAGSSVGEYAALAA 136 Query: 122 LVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPMLAKMTPN 178 ++ A +E N SCP + G P AV+ + +P+ AK++P+ Sbjct: 137 RLRGAAPVVALEVNISCPNVEDR--GQVFACDPRAASAVLAAVREAADPAVPVFAKLSPD 194 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ VA A GADG++ INT+ + ++ + P ++G + G SG A++P+A Sbjct: 195 VTDIVAVATACVAAGADGLSLINTLLGLV---IDTETLRPALSGVT--GGLSGPAIRPVA 249 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +R + Q+ H L D PI G+GGI + DA +FLL GA + V T I + + Sbjct: 250 VRCVWQV--HAALPDVPIIGMGGIRSGLDALQFLLAGACAVSVGTEIF-HDPSAPARIRD 306 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 L+ LA +GF + +++GLA+ AE D Sbjct: 307 ELAEALAARGFQRVSDVIGLAHRGGSVAEGGD 338 >UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobacteria RepID=Q1GGD3_SILST Length = 352 Score = 224 bits (571), Expect = 4e-57, Method: Composition-based stats. Identities = 73/328 (22%), Positives = 125/328 (38%), Gaps = 32/328 (9%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 + + L G+ PNP L++ N E A + G+G + P Sbjct: 39 VTSPRLRTDVAGLSLPNPVGLAAGFDKN-AEALAPLSEAGFGFIEVGAATPRPQPGNPKP 97 Query: 60 RFDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-- 115 R L ++ GF N E + + + P +I +G N+ Sbjct: 98 RLFRLSEDRAAINRFGFNN----------EGMDTIGKRLAQRPKSGVIGLNLGANKDSED 147 Query: 116 -WEELARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPM 171 ++ AR++ GA D N S P L+ A + +P+ Sbjct: 148 RAQDFARVLSHCGAHLDFATVNVSSPNTEKLRDLQGKDALASLLAGVIDAREALQRPIPV 207 Query: 172 LAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ + ++A A+ G D + A NT S + + + G Sbjct: 208 FLKIAPDLDISGLDDIAEVARDSGIDAVIATNTTLSRDGLKSTHR---------DEMGGL 258 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG + + R + Q+ + PI G+GGI T E A + GA+ +Q+ T ++ G Sbjct: 259 SGAPLFERSTRVLAQLSQRLD-GAVPIIGVGGISTAEGAYAKIRAGASAVQLYTALVYGG 317 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVG 317 + ++ASGL LA GF ++ E VG Sbjct: 318 LSLASEVASGLDALLARDGFSNVAEAVG 345 >UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 Tax=Planctomycetaceae RepID=D2QWH7_9PLAN Length = 315 Score = 224 bits (571), Expect = 4e-57, Method: Composition-based stats. Identities = 90/314 (28%), Positives = 146/314 (46%), Gaps = 19/314 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHL 64 DLS+T ++ NP +S G EM + + GG++ KT+ +P Sbjct: 12 DLSVTLGRLRLRNPILTASGTFGYAREMESLVDFSKLGGILPKTVTQQPRAGNTPW--RT 69 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 V+ G + ++ +E +A P +I SI G N ++ +A + Sbjct: 70 VETTAGLLNAIGLDNDG---IETFIAHHMPYLGSLPTS-IIVSIAGSNHNEFVAMAGRLS 125 Query: 125 EA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + G IE N SCP + G D G L EK + + P+LAK+TPN+ + Sbjct: 126 DIDGIAAIELNISCPNVAH---GIDFGADASLCEKLVSDCVKATRHPILAKLTPNVTRIA 182 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +VA A GGAD ++ INTV+ + ++ + P++ + + G SG A+KPIALR + Sbjct: 183 DVAKGAANGGADALSLINTVQGMA---IDWRKQKPLLG--NVMGGLSGPAIKPIALRCVH 237 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q+R I GI T +D EF++ GA+ +Q+ T Y + +A+ L Sbjct: 238 QVRQAVSTPIIGIGGI---ATIDDVMEFIVAGASAVQIGTAN-YYDPTVTMKLAAALPFA 293 Query: 304 LADQGFDSLQEMVG 317 L + G S+ E+VG Sbjct: 294 LQEIGAKSIAEVVG 307 >UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=B8EIT2_METSB Length = 337 Score = 223 bits (569), Expect = 7e-57, Method: Composition-based stats. Identities = 71/332 (21%), Positives = 131/332 (39%), Gaps = 26/332 (7%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL + G+ P S+SP+ + + D+G G VV ++ E + D Sbjct: 1 MDLRTRYLGLSLRTPLIASASPLSGDVGLIRQMEDSGAGAVVLPSLFQEQIEEEARAADE 60 Query: 64 LVK----EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 L + + L + R + D +IAS+ G W + Sbjct: 61 LARIGADSSPEASSYFPAVVTYNSGPHGYLDLVARARAAV-DIPVIASLNGTTVAGWVDY 119 Query: 120 ARLVQEAGADMIECNF----SCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 ARL+++AGA +E N S P +T +D AV+ LP+ K+ Sbjct: 120 ARLIEQAGATALELNIYRIASGPGVTGGQAEAD-------CVALLEAVRSRVKLPVAVKL 172 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 P + A GADG+ N + +IDL + + + SG Sbjct: 173 HPYFSAFGDFAQQLDHAGADGLVLFNRLYQ-PDIDLLRLAWK-------NDATLSGAGEI 224 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 + L ++ + L ++ G++T E+ +++L GA + + ++++G + Sbjct: 225 RLGLLWLSVLSGR--LPHASLAAGTGVDTAEEVIKYILAGANAVMTASSLLRHGPGHLRT 282 Query: 296 MASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 + SGL +L+ +GF S+ + GL + +E Sbjct: 283 LVSGLETWLSTRGFASVSAITGLMRPSHPDSE 314 >UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsiales RepID=B3CMR9_WOLPP Length = 355 Score = 223 bits (568), Expect = 1e-56, Method: Composition-based stats. Identities = 64/332 (19%), Positives = 133/332 (40%), Gaps = 37/332 (11%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 L K L++ F G K +P L++ N E+ G+G + T+ PR Sbjct: 48 LPKSLNVNFFGNKIRSPVGLAAGFDKN-AEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPR 106 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN---EQQ 115 L+K++ +GF N ++ L +++ E + +G N + Q Sbjct: 107 IFRLIKDEGIINRLGFNN------KGVDYFL---KQISETKLGNCIFGINIGRNSTSKDQ 157 Query: 116 WEELARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC---RAVKRGSTLP 170 + L++ ++ I N S P + + + +L++ +++ ++P Sbjct: 158 ISDYVDLIKIVYGKSNYIVLNISSPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESIP 217 Query: 171 MLAKMTPNIGDM--CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 ++ K++P+I +A DG+ NT S + + G Sbjct: 218 IILKISPDIDQQTKENIAELTLEYKIDGLIVSNTTISRD-------------SYYNESGG 264 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG+ + ++ + M + + G GGI + DA E + GA+ +Q+ T ++ Sbjct: 265 LSGRPLFQLSTELLSDMYKLTK-SRILLIGCGGISSGVDAYEKIKAGASLVQLYTALVYQ 323 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 G+++V + L+ + GF ++ E VG + Sbjct: 324 GHQVVNKINLELAELVKRDGFSNITEAVGCIH 355 >UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SLA1_9BACT Length = 328 Score = 223 bits (568), Expect = 1e-56, Method: Composition-based stats. Identities = 77/353 (21%), Positives = 134/353 (37%), Gaps = 34/353 (9%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS---- 58 D+ +F G+ NP + SS + + E D G VV K++ + Sbjct: 1 MSDIRTSFMGLTLKNPVIVGSSTLTDTPEKIKALADNGAAAVVLKSLFEQEVRNLKDSAQ 60 Query: 59 -----PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE 113 P + D G + + + E L +R K D +IASI E Sbjct: 61 CCNYHPEAYYYDMSDAGML----------YGISEYLQLIRDAK-LATDIPVIASICCEKA 109 Query: 114 QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 W+ + AGAD +E N + + +D+ + + VK + LP Sbjct: 110 AWWKTYPERIANAGADALELNINMLSLHGAKSPADIYKD---TLQIIHTVKNTTDLPFSV 166 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K++P + + K GA G+ + + + I+ N P S YS Sbjct: 167 KLSPYCCSIPYLVKMLKEEGAKGVTLFSRLFEL-GINTNTFECEP-------ASYYSSPE 218 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 LR++ + E D I G GI T + + ++ GA +Q+ + I + G I+ Sbjct: 219 ETFKVLRWVHLVS---EQVDIEICGNTGIHTSREIIQHIIAGAGAVQMVSSIYKNGPEII 275 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVG 346 L Y+ D+ F++L E+ G + + L + + + R LD +G Sbjct: 276 RTCLEELEQYMFDRQFNTLHELKGFLSTKEKDFDLLYFNSLTHDRFQLDSHMG 328 >UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobacterales RepID=PYRD_SULDN Length = 352 Score = 223 bits (568), Expect = 1e-56, Method: Composition-based stats. Identities = 74/329 (22%), Positives = 131/329 (39%), Gaps = 40/329 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G F NP L + N M G+G TI A PR Sbjct: 51 LKQELFGRTFFNPIGLGAGFDKN-ATMIRAMQILGFGFTEIGTITPKAQAGNPKPRMFRH 109 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------Q 114 ++E + +GF N E L+A +RLK+ +P I +G+N+ Sbjct: 110 IEEQSIQNAMGFNN---------EGLLSAQKRLKKRFPFTTPIGINIGKNKLTPDTQAIN 160 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 + L + + E G D + N S P Q+ E + K K ++ P+L K Sbjct: 161 DYTTLIKALHELG-DYLVINISSPNTPGLRDL----QNEEFITKLFEESKAITSKPILLK 215 Query: 175 MTPNIGDMCEVALA--AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ VAL A GADGI A NT + +V SI G SG Sbjct: 216 IAPDMSKEDAVALTKLAVLKGADGIIATNTT-----------VDYSLVKEPKSIGGLSGA 264 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 +K + + + + + +GGI + ++ + GA+ +Q+ +G++ G + Sbjct: 265 VLKEKSFEIFEAVAKELYGKT-TLISVGGISSAKEVYRRIKAGASLVQIYSGLIYEGPDL 323 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANN 321 ++++ + L+ + G+ ++ + +G Sbjct: 324 IKNINNELTELIKADGYTNITQAIGADRK 352 >UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroides RepID=C3PUX9_9BACE Length = 324 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 134/336 (39%), Gaps = 17/336 (5%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L TF G+ NP +SSS + N E K G G +V K++ ++ H+ Sbjct: 4 LKTTFAGLSLRNPIIISSSSLTNSAEKNKKLELAGAGAIVLKSV---FEEQIMMEAHHMA 60 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 + + H L E ++ + + K+ +IASI + +W + AR V+ Sbjct: 61 TYGSPEGDDYLSTYVRSHALNEYISLIEQTKK-LCTIPVIASINCFSNSEWTDFARTVET 119 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 AGAD +E N Q G + ++K+ ++P++ K+ N+ + + Sbjct: 120 AGADALEINILSLQTEKEY---QCGSFEQRHIDIVSSIKKQISIPVIVKLGSNLTNPIAL 176 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 GA+ + N +I+++ S+ +S A LR+ Sbjct: 177 INQLYANGANAVVLFNRFYQ-PDINIDTMT-------YSAGDVFSTPADLSNGLRWTAIA 228 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 D+ IS GG+ + + +L GA+ +++ + I Q G +++ DM + ++ ++ Sbjct: 229 SAQVPQTDYAIS--GGVHDGKAIVKAILAGASAVELCSVIYQRGNQVIADMTNEITQWMN 286 Query: 306 DQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINL 341 QG+ ++ E N A + + Sbjct: 287 RQGYKNISEFKSSMNALSTGASNPFERTQFMKYFSS 322 >UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family protein n=1 Tax=uncultured actinobacterium RepID=D0U5Z4_9ACTN Length = 324 Score = 221 bits (564), Expect = 3e-56, Method: Composition-based stats. Identities = 84/326 (25%), Positives = 143/326 (43%), Gaps = 26/326 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 D S+ V+F +P L+S G+ E+ + G +V K++ F A +PR Sbjct: 8 DHSVRVDDVEFKSPVLLASGTAGHADELEPYFPLSKIGAIVVKSMSSFEWAGNKAPR--- 64 Query: 64 LVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L + G + ++ + H +E +L L+++K ++ASI G + + A L Sbjct: 65 LRPTNGGMLNAVGLQGLGVAHWIEHDLPRLKKVKAT-----IVASIWGFSIDDYRSAASL 119 Query: 123 VQEAGAD--MIECNFSCPQMTSHAMGSD-----VGQSPELVEKYCRAVKRGSTLPMLAKM 175 + E D IE N SCP + S + ++ +L + R V + +P+ AK+ Sbjct: 120 LSEVSTDLAAIEINLSCPNIGSSSKAANTPHGIFAHDEDLSAEIVR-VCSVAKVPLWAKL 178 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 +PN + +VA A + G + INT + ID+ + G + Sbjct: 179 SPNTDRVVDVAAAVSKAGCQAVTLINTALGLA-IDVETGLPALGNGGGGLSG----SGIH 233 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 PIA+R I +RT L PI G+GGI EDA E ++ GA+ +QV T R Sbjct: 234 PIAVRTIFDVRTR--LPRLPIIGVGGIANGEDAIEMMMAGASCIQVGTATF-ADPRAAMR 290 Query: 296 MASGLSHYLADQGFDSLQEMVGLANN 321 + + + G ++ E+V A+ Sbjct: 291 IDREMRQWARKHGVNNWSEVVNAAHK 316 >UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaproteobacteria RepID=PYRD_AGRT5 Length = 363 Score = 221 bits (563), Expect = 4e-56, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 134/339 (39%), Gaps = 35/339 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L T G+ FPNP +++ N E+ G+G T+ PR Sbjct: 43 PRLQQTVAGLVFPNPLGMAAGYDKNA-EVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIF 101 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 LV+++ +GF N E + AAL RL + ++ +I G N+ + +A Sbjct: 102 RLVEDEGVINRLGFNN---------EGHAAALERLTQARLRGIVGVNI-GANKDSEDRIA 151 Query: 121 RLVQE-----AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLP 170 VQ A A N S P L+ K + +P Sbjct: 152 DYVQGIEAFYAVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIP 211 Query: 171 MLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 + K+ P++ + + +VA A DG+ NT S + G+ + G Sbjct: 212 IFLKIAPDLTEEGLDDVAEEALAHDLDGLIVSNTTLS--------REGLRPGPHRGEAGG 263 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SGK + ++ + +MR + PI G+GG+ + E A E + GA +Q+ + ++ Sbjct: 264 LSGKPLFELSTTVLAKMRRRVGA-NLPIIGVGGVSSAETALEKVRAGADLVQLYSCMVYE 322 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 G + + G+S +A +G ++++++ A + + Sbjct: 323 GPGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADRK 361 >UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglobaceae RepID=PYRD_ARCFU Length = 299 Score = 220 bits (561), Expect = 7e-56, Method: Composition-based stats. Identities = 79/318 (24%), Positives = 139/318 (43%), Gaps = 24/318 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L G++ NP L+S +G+ G VV K++G R +V Sbjct: 4 LETEIGGLRMKNPLMLASGIMGSKV-HSLNLIARDAGAVVTKSVGVEEREGY--RNPTVV 60 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 G I + A E L K+ + L+ S+ G + +++ +L Sbjct: 61 NWKCGLINAVGLASPAAKDFAEEL------KDYTNEAPLLISLYGHSVEEFSDLVDTFDS 114 Query: 126 AGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 A E N SCP + G D+G EL +K + P+ AK++ + D Sbjct: 115 ALPYLHGYELNLSCPHVKGA--GLDIGMDLELSAAIVEELKGKTKNPVFAKLS-AMHDYL 171 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 ++A + G DGI NT++ + ++ G P+++ S G SG A+KPIAL+ + Sbjct: 172 KLAKVLEDAGVDGITISNTLRGM---KIDIMSGKPVLSNLS--GGVSGPAIKPIALKCVY 226 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + E PI G GGI ++ED EF++ GA +Q+ + + Y RI + L + Sbjct: 227 DLYKEIE---VPIVGCGGITSFEDVLEFIMAGARAVQIGSAV-YYSRRIFYSLKESLIAF 282 Query: 304 LADQGFDSLQEMVGLANN 321 + ++ +++G+A++ Sbjct: 283 TRARDC-TISDLIGIAHS 299 >UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=Streptomyces ambofaciens ATCC 23877 RepID=A0ADR6_STRAM Length = 297 Score = 220 bits (561), Expect = 7e-56, Method: Composition-based stats. Identities = 81/314 (25%), Positives = 131/314 (41%), Gaps = 23/314 (7%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 G++ +P + S + + + +D G VV KTI R L Sbjct: 6 RILGLRLSSPVVVGSGLLTDQERNIRRLFDDGASAVVTKTIHPDPGPAGEERLLRLPT-- 63 Query: 69 TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGA 128 G N + P+ + A LRR +D +IAS+ E+ + ELA LV +AG+ Sbjct: 64 ----GMLNSTTYSRRPVGDWCAMLRRFADD--GLPVIASVHAESPDELAELADLVGQAGS 117 Query: 129 DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALA 188 +E SC + +PE V Y AV+R + +P K+ + E A Sbjct: 118 PALELGISCLNEGGG-----LDDTPERVAAYTDAVRRRTPVPFSVKLAAG-ERLRERVEA 171 Query: 189 AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH 248 A GAD I +TV + ++ G + G GYSG +KP+ L I +R Sbjct: 172 ALACGADAITLSDTVAGLA---VDADTGEVRLGGAF---GYSGAGIKPLVLAEIFGLRRA 225 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 P+ GG+E D AE+L +GA +QV T + + + + + G +L G Sbjct: 226 G--LTVPVMASGGVENGRDVAEYLSVGADAVQVYTALHREMHATLRAIRRGFDEWLGAHG 283 Query: 309 FDSLQEMVGLANNN 322 ++ ++VG + Sbjct: 284 -GTVADLVGRSVKR 296 >UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae RepID=A9HBE5_GLUDA Length = 357 Score = 220 bits (560), Expect = 9e-56, Method: Composition-based stats. Identities = 69/328 (21%), Positives = 121/328 (36%), Gaps = 30/328 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++ G++FPNP +++ N + G+G V T+ PR L Sbjct: 46 LAVRALGLRFPNPIGIAAGFDKNAL-VVRPLARIGFGFVEAGTVTPRPQPGNPRPRLFRL 104 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------QQW 116 ++ +GF N L + +V + + +G N+ + + Sbjct: 105 DEDRAIINRMGFNNQGIDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADPERDY 164 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 L V+ AD + N S P + + L++ A P+L K++ Sbjct: 165 PRLVGRVKHY-ADYVVLNLSSPNTPGLRDLQEASRLGALLQAIGEA--HPDRPPLLVKLS 221 Query: 177 PNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ D+ + AA GGA G+ NT S G SG+ + Sbjct: 222 PDLARDDIGPIVEAAIAGGAQGLIVTNTTISRP--------AGLRSPHAGEAGGLSGRPL 273 Query: 235 KPIA---LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 +P+A R + Q+ + GGIET D + + GA +Q+ + G Sbjct: 274 RPLAADIFRAVAQVAA----GRLALVACGGIETGADIVDRVRAGADLVQLYSAFAYEGPG 329 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLA 319 IV + L +GF++L + G A Sbjct: 330 IVRRLKRETVRVLNAEGFETLADAKGTA 357 >UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular organisms RepID=PYRD_SYNPX Length = 396 Score = 220 bits (560), Expect = 9e-56, Method: Composition-based stats. Identities = 79/338 (23%), Positives = 133/338 (39%), Gaps = 22/338 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 L G +FPNP L++ N G+G T+ + PR Sbjct: 68 RLEQVLFGCRFPNPVGLAAGFDKNGVAA-GLWDRFGFGFAEVGTVTWHGQPGNPRPRLFR 126 Query: 64 LVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQW 116 L +E +GF N L L +RL ++ +G+++ Q Sbjct: 127 LAQEQAALNRMGFNN---DGAQALRRTLER-QRLAPPGRRPAVLGINVGKSKVTALEQAP 182 Query: 117 EELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 E+ A ++ AD N S P D Q LVE+ + + P+L K Sbjct: 183 EDYASSLELLAPLADYAVINVSSPNTPGLRDLQDSSQLRRLVER---LRRLPACPPLLVK 239 Query: 175 MTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D + +A A G G+ A+NT ++ +++ G SG Sbjct: 240 IAPDLEDEAIDGIARLAFEEGLAGVIAVNTSLDRLGLE-QRRLLQTGRTLAEEAGGLSGA 298 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 ++ AL I+++R + G+GGI++ E A E + GA+ +Q+ TG + G + Sbjct: 299 PLRQRALEVIRRLRASAG-PALTLIGVGGIDSAEIAWERITAGASLIQLYTGWIFQGPEL 357 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 V + GL L G S+ E VG + +ED + Sbjct: 358 VPRILEGLQLQLDRHGLRSIAEAVGSGLPWLPGSEDAE 395 >UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 Tax=Saccharomycetales RepID=PYRD_ASHGO Length = 444 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 72/343 (20%), Positives = 133/343 (38%), Gaps = 40/343 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + G NP ++ + E +G+G V T+ PRF L Sbjct: 107 LKVEVFGKTMSNPIGCAAGLDKDG-EAIDGIAQSGFGYVEIGTVTPLAQPGNPKPRFFRL 165 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYP-----------DKVLIASIMGE 111 ++ GF + + + L+ +R+ Y L+ +G+ Sbjct: 166 PMDEAVINRYGFNSSGH--KKVYDNVLSRVRQFLGAYFRDDTVNSLALYKDKLLGINLGK 223 Query: 112 NE--QQWEELARLVQ--EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS 167 N+ + E+ R V+ ++ AD++ N S P G+ EL+ Sbjct: 224 NKNGDEVEDYLRGVEKFQSLADVLVINVSSPNTPGLRDLQQEGRLTELLSMIVAKRNSLI 283 Query: 168 T-----------LPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQK 214 P+L K+ P++ + + +A AAK+ DGI NT + Sbjct: 284 NEGNVLGASTHKPPVLVKIAPDLTEPELQSIAEAAKKSSIDGIIVSNTTIQRPDSLYTVD 343 Query: 215 IGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLL 274 + K+ G SGK VKP AL+ ++ + + + + + G GGI + +DA EF Sbjct: 344 EEL-----KNQAGGLSGKPVKPFALKALRTIHQYTKDTNLVLVGCGGISSGQDAIEFAKA 398 Query: 275 GAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 GA +Q+ T G ++ + ++ L ++G + E++G Sbjct: 399 GAHFVQLYTAYAYRGPGLIARIKDEVTEELRNEG-KTWMEIIG 440 >UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacter RepID=C3XDT6_9HELI Length = 357 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 136/331 (41%), Gaps = 35/331 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + ++L+ G+ F NP L+S N E G+G + ++ PR Sbjct: 47 IHENLAQDIHGLHFYNPIGLASGFDKN-AEAVRPLASLGFGYLELGSVTQMPQDGNEKPR 105 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ--- 115 V+E++ +GF N+ L LKE YP + + +G+N+ Sbjct: 106 MFRHVEEESLQNAMGFNNIGARG---------MLAHLKEVYPFCIPLGINIGKNKNIAQG 156 Query: 116 -----WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 +E +++ G D N S P Q+ V++ K + P Sbjct: 157 DSLKNYELSLDTLKDYG-DYFTFNLSSPNTPGLRDL----QNESFVKELMEMAKSTTNKP 211 Query: 171 MLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 + K++P++ M V AA + G +GI A NT +ID + + P+ G Sbjct: 212 IFIKISPDMEIESMLAVCDAAIQNGVNGIIATNT-----SIDYS-LVSNPVKKNDVCFGG 265 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SGKA+ + ++ + + + + +GGI + E + LGA+ +Q+ + ++ Sbjct: 266 LSGKAISTKSKEVLRILGKNFH-KKTTLISVGGIGDSNEVYERIKLGASLVQILSSMIYE 324 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 G ++ M + L+ L GF + E +G+A Sbjct: 325 GPTLISRMNNELAEKLKADGFKHINEAIGVA 355 >UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UZD6_NAEGR Length = 369 Score = 218 bits (555), Expect = 4e-55, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 123/339 (36%), Gaps = 22/339 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L G F NP L++ E G+G + +I PR Sbjct: 37 SLHTNCLGYHFENPIGLAAGFDK-DAECMKGIEKLGFGFMEVGSICPQPQPGNPKPRIFR 95 Query: 64 L---VKEDTGFI--GFKNMEQIAEHPLEENLAALRRLKEDY--PDKVLIASIMGEN---- 112 L V + G I N +E + L + Y + I +G+N Sbjct: 96 LNSKVSDPDGTIFDTILNRCGFNSKGMEVSDENLTTYRNSYQSLNTFPIGVNLGKNKTSA 155 Query: 113 EQQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 + E+ V++ AD + N S P + L+E+ +K+ +P Sbjct: 156 PESIEDYLIGVRKLAKHADFLVINVSSPNTQHLRSLQEKSSLDTLIEEVSTELKKHKNIP 215 Query: 171 MLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ ++A A + GI NT + Q +P S G Sbjct: 216 LLIKIAPDLTLDQQRDIASLALKHSIGGIIVSNTTIERPFVSSEQINAIP----NGSAGG 271 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG+ + + + ++ M E + + G+GG+ DA + + GA+ +QV T Sbjct: 272 MSGRPLFNQSTKVLKNMYKLTEGK-VTLIGVGGVWDGYDALQKIQAGASLVQVYTAFTAQ 330 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 G +V + L+ LA+ G+ + + VG E Sbjct: 331 GPAVVGKIKRELAQLLAEGGYARVSDAVGSKAKFSKLEE 369 >UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMB2_9BACT Length = 304 Score = 217 bits (553), Expect = 5e-55, Method: Composition-based stats. Identities = 78/320 (24%), Positives = 135/320 (42%), Gaps = 21/320 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 DLS+ V +P ++S G + + G V K I R Sbjct: 3 DLSVNIGSVPLRSPVIIASGTWGYDESLWREDLLRHVGAVCSKAITESPKDGNPGHRIWE 62 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 IG +N + ++E + L+ +IA++ E+E+ + + Sbjct: 63 TPCGLLNSIGLQNTGI--DDFVDEKIPKLKSY-----GVPIIANVSMEDERGLALIVERL 115 Query: 124 QEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 E D IE N SCP + M G SP L + V++ P+ KMTP D Sbjct: 116 VEVADCVDAIELNVSCPNVDKGCM--SWGVSPVLTSQAVSMVQKIWKGPLWVKMTPQAPD 173 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 VA AA+ GAD + NT + ID++ + + ++G+SG AV P+ALR Sbjct: 174 PEGVARAAEDSGADALVVANTWLGMA-IDVDSRKAV----FDRVVAGFSGPAVFPMALRL 228 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q+ + P+ G GG+ + D ++ GA +++ TG M R+ E++ + Sbjct: 229 VWQVSSAV---SIPVIGCGGVSSGRDLLSMIMAGATAVELGTG-MFRDIRLPENILREVK 284 Query: 302 HYLADQGFDSLQEMVGLANN 321 Y+ + + L+ ++G+A Sbjct: 285 AYMTKEKVEDLRSLIGIAKR 304 >UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Rickettsiales RepID=B9KHW9_ANAMF Length = 389 Score = 217 bits (553), Expect = 6e-55, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 135/331 (40%), Gaps = 33/331 (9%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + + LSI C ++F P L++ N E+ G+G V T+ PR Sbjct: 75 MPECLSIEVCHLRFRTPIGLAAGFDKN-AEVIKPLIGMGFGFVEAGTVTKKPQSGNKRPR 133 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN------ 112 +V + +GF N ++++ + ++ + +G N Sbjct: 134 LFRIVDQKAVVNRLGFNNKGIQ---------RFIKKIDRKELNNLVFGANLGINKTCTDP 184 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC---RAVKRGSTL 169 ++ E+ R V + I N S P + G E++ R+V + ++ Sbjct: 185 PAEYAEMVRSVYGL-SSYITINVSSPNTAGLRDLQNRGPLSEILSSVRDARRSVDQAESV 243 Query: 170 PMLAKMTPNIGDMC--EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+ K+ P+I D ++A + G+ NT ++ + ++ N + Sbjct: 244 PIFLKIAPDISDELKQDIAEEIVKHKISGLIVSNTTTDLSLLGKDR-------NKSITQG 296 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ + ++ + +M + + + G GG+ + A + + GA+ +Q+ T ++ Sbjct: 297 GLSGRPLFDLSTTVLSEMYSLLRDKVI-LIGCGGVSSGAQALQKIKAGASLVQLYTALVY 355 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G+ +V+ + L+ L +GF +++ VG+ Sbjct: 356 EGFGVVKKINMELAELLTQEGFSKVEQAVGV 386 >UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphylococcus RepID=Q2YWG7_STAAB Length = 354 Score = 217 bits (552), Expect = 7e-55, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 132/323 (40%), Gaps = 25/323 (7%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 LS T G + NP L++ +C E+ G+G + I PR Sbjct: 47 PTLSQTIQGNTYDNPIGLAAGFDKSC-EVPKALEHLGFGALELGGITPKPQPGNPQPRMF 105 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI-MGENEQQWEEL 119 L+++D +GF N+ + + L+ LR+ P + + M E ++++ Sbjct: 106 RLLEDDALINRMGFNNI------GMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDY 159 Query: 120 ARLVQEAGADM--IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-RGSTLPMLAKMT 176 +++ D+ N S P + D + L + K T+P+ K+T Sbjct: 160 IKVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIYLKLT 219 Query: 177 PNIG-DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 ++ D + L A DGI NT + + K G SG+ + Sbjct: 220 SDMDFDGLKALLPAITETFDGIILANTTRQRDGL---------TSANKVEEGGLSGRPLF 270 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 L+ I+ +F I G GG+ + EDA + + GA+ +Q+ + ++ G + + Sbjct: 271 ERNLKLIKYAYQQTN-GEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLVIEGPGLTKK 329 Query: 296 MASGLSHYLADQGFDSLQEMVGL 318 M G++ YL D FD++ +++GL Sbjct: 330 MNKGIARYLKDHHFDNVSDILGL 352 >UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=Q1V0W4_PELUB Length = 350 Score = 217 bits (552), Expect = 7e-55, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 127/327 (38%), Gaps = 31/327 (9%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLV 65 G NP +++ N E+ + G+G V T+ PR LV Sbjct: 44 KTNLFGKNIDNPIGMAAGFDKN-AEVYNPLFKLGFGFVEVGTVTPLEQYGNPKPRVFRLV 102 Query: 66 KEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 ++ +GF N+ + K L+ +G N+ + L + Sbjct: 103 EDQALINRLGFNNLGA----------ENISHRIRSNSHKGLLGINIGPNKDSEDRLNDYL 152 Query: 124 QEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA-VKRGSTLPMLAKMTP 177 AD I N S P + D + EL+ + VK S +P++ K++P Sbjct: 153 IGLRNFYDIADYITVNISSPNTENLRAFHDETKFDELLNAIEKEKVKLKSKIPIVVKISP 212 Query: 178 NIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 +I D + ++ + I NT N++ I+ K G SGK ++ Sbjct: 213 DISDEQIELISKILIKHKVSAIIVSNTTA------KNREKLNNIL--KHQKGGLSGKPLE 264 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 A + I + + + I G+GG+++ E A + GA+ +Q+ TG++ G IV Sbjct: 265 EEANKLISKFYKLLKGK-IEIIGVGGVDSGESAYKKFQAGASYVQLYTGMVFQGPNIVGK 323 Query: 296 MASGLSHYLADQGFDSLQEMVGLANNN 322 + L L D+G + +E++G N Sbjct: 324 IKKELKEILIDEGIKNFKEIIGKKLTN 350 >UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospirillum RepID=Q2W4R2_MAGSA Length = 329 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 69/346 (19%), Positives = 136/346 (39%), Gaps = 22/346 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ + G+ NP +S+SP+ + D G +V +I + Sbjct: 1 MNLATRYLGLDIKNPLVVSASPLALDLGNSRRLEDCGAAAIVLPSIFQEDIENEIDEIER 60 Query: 64 LV-KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 LV + ++ + A + L +RR +E + +IAS+ G W E A Sbjct: 61 LVCEGNSEAFSYFPANISANAGPKNYLDLIRRTREAL-EIPVIASLNGTTRTGWTEYAAQ 119 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 Q+AGA IE N G++V + VK ++P+ K++P + Sbjct: 120 SQQAGASAIELNVYLLPTDMDMSGTEVES---RYLEILEDVKSAVSIPVSMKLSPYFSSV 176 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + G DG+ N +IDL++ + + S K + L +I Sbjct: 177 GNMVKVLDDHGVDGVVLFNRFYQ-PDIDLDELKLVRDLK-------LSHKGEIRLPLLWI 228 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + I+ G++T + ++L +GA + T+ +M++G ++ + GL Sbjct: 229 ATLAGKIKAS---IAASSGVQTAAEVVKYLFVGADVVMTTSALMRHGVDYMKTLHDGLIA 285 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCG 348 L ++ +S+ ++ G + R Y R+N + + G Sbjct: 286 ELKEREAESVADIRGKMSRGAT------RDLAAYDRVNYIRILRGG 325 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 69/318 (21%), Positives = 135/318 (42%), Gaps = 20/318 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 +++ G++ NP ++ G ++ + G + K + +PR L Sbjct: 7 MAVNLGGIQMKNPINTAAGTFGYGWQFEGFYDVSLLGAITMKGVARVPWEGNPAPRMCEL 66 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 +G N + + ++ L++ +I + + Q+ ++ ++ Sbjct: 67 NGGMMNSVGLANPG--VDDFIAHTDDYMKDLEDR--GTRVIMQMAAHSVQEMIDVVERLE 122 Query: 125 EAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 E IE N SCP + G +G +PE + +AV+ + LP+L KM P ++ Sbjct: 123 ELNPHISAIELNVSCPNLEKG--GRPLGGTPEQATEIMKAVRPLTKLPILVKMAP--VNV 178 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E+ A + GADG+ IN++ ++ I+++ + G SG A+R + Sbjct: 179 AEIGKAFEAEGADGLTLINSIPGMS-INVHTRKSR----LSKPTGGLSGPLCHNAAVRMV 233 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + PI G+GG+ET EDAAEF+L GA + V + + + + L+ Sbjct: 234 WECA---QAVSIPICGVGGVETGEDAAEFILAGATAVSVGSANLY-DPMCAPRILNELTD 289 Query: 303 YLADQGFDSLQEMVGLAN 320 + QG + E++G Sbjct: 290 WAKSQGVSDIHELIGAVE 307 >UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago maydis RepID=Q0GF37_USTMA Length = 677 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 74/381 (19%), Positives = 133/381 (34%), Gaps = 75/381 (19%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G K NP L++ E D G+G + ++ PR+ L Sbjct: 140 LETELFGRKLSNPIGLAAGFDK-QAEAIDGLLDLGFGFIEIGSVTPEPQPGNPQPRYFRL 198 Query: 65 VKEDT--GFIGFKNMEQIAEHP-----LEENL---AALRRLKEDYPDKVLIASIMG---- 110 ++++ GF + + L +++ L++ AS+ Sbjct: 199 IEDNACINRFGFNSEGHNVILSRLRDRIRRWLLHSSSVANLQDALLASPDSASVNARQLI 258 Query: 111 -----------------------------------ENEQQWEELARLVQEAG--ADMIEC 133 NE+ ++ + V+ G ADMI Sbjct: 259 ATHPKSTSAFVDATDLPRSLRPAKMLGINLGKNKTSNEESVDDYVKGVERLGPYADMIIV 318 Query: 134 NFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-----------RGSTLPMLAKMTPNIGD- 181 N S P G +L+ + RA + +P+L K+ P++ + Sbjct: 319 NVSSPNTPGLRRLQRRGVLEDLLTQVVRARDGMVESHLRFSDKKVAVPLLVKIAPDLSEE 378 Query: 182 -MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + +VA AA + G DG+ NT S + G SG VKP+AL+ Sbjct: 379 ELHDVADAALKSGIDGLVISNTTISRP-------ASLRSSEHVRETGGLSGAPVKPLALK 431 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + + + PI G GGI +DA ++ GA+ +++ T G + + L Sbjct: 432 ALTTVHKRLQGK-LPIIGCGGISNGQDALDYAKAGASAIELYTSFGYQGVGLPRRLKDEL 490 Query: 301 SHYLADQGFDSLQEMVGLANN 321 L +G + Q++VG + Sbjct: 491 VELLKAEG-KTWQQVVGSGLD 510 >UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter vinelandii DJ RepID=C1DSD9_AZOVD Length = 332 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 75/319 (23%), Positives = 132/319 (41%), Gaps = 17/319 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ T+ G+ NP S+SP + + D G G VV ++ + + Sbjct: 1 MNLTTTYLGLSLRNPLIASASPQNAELDHLHRLDDAGIGAVVLPSVFQEQLEAGANDYAS 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPL--EENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + F + + + E +LA + R K + +IAS+ G + W A Sbjct: 61 IGAACSDVPAFLPPVEGGPYGMIPESHLALIMRAKAELS-VPVIASLNGASANHWTHYAA 119 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 L++EAGAD +E N + G+ V Q + AV+R +P+ KM P Sbjct: 120 LLEEAGADALELNLYFVPVDPLEPGTAVEQ---RYLEVLAAVRRTVKIPVAVKMPPYFSA 176 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + +A GGADG+ N +IDL + + + S + L + Sbjct: 177 IGNMASRLLEGGADGLVIFNRYLQ-PDIDLQRLQPISTLE-------LSSPGEMRLPLLW 228 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 I + + ++ GG+E E ++LL GA T+ T I+++G V + GL Sbjct: 229 IALLAGRVKGS---LAASGGVEDVEQVVKYLLAGADTVMTTAAILRHGPAHVHTLLCGLE 285 Query: 302 HYLADQGFDSLQEMVGLAN 320 +L + SL+ + G + Sbjct: 286 AWLQSRRGQSLERIRGQMS 304 >UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_SYNY3 Length = 381 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 80/329 (24%), Positives = 126/329 (38%), Gaps = 27/329 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L T G+ FPN LS+ E A G+G + + PR Sbjct: 58 PRLQQTCWGLNFPNVLGLSAGCDKEG-EAAAVWPALGFGFAELGAVTKYAQPGNDRPRLF 116 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 L ++ +G N +A A L+ + YP + I + +++ Q Sbjct: 117 RLPQDQAVLNRLGANNEGAVA------MAAKLKHTWDYYPRTIPIGINLCKSKITPLDQA 170 Query: 116 WEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 E+ Q AD N S P + + P + A P+L Sbjct: 171 VEDYVFSFQTLAPVADYFVVNVSSPNTPGLRSLQESDELPRIFAGLQSA--NHWQKPLLV 228 Query: 174 KMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNID--LNQKIGMPIVNGKSSISGY 229 K++P++ + + K GI A NT + + + + G PI + G Sbjct: 229 KISPDLSWEAIAVIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPI---EQEAGGL 285 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG+ ++ A I+ + PI G+GGI T EDA E + GA+ LQ+ TG + G Sbjct: 286 SGQPIRDRATEVIRYIYQQTGGT-IPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGG 344 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGL 318 +V D+ GL LA GF + E VG+ Sbjct: 345 PWVVSDILQGLGEKLAAGGFSHISEAVGI 373 >UniRef50_C4T7U5 Dihydropyrimidine dehydrogenase n=1 Tax=Yersinia intermedia ATCC 29909 RepID=C4T7U5_YERIN Length = 397 Score = 216 bits (551), Expect = 9e-55, Method: Composition-based stats. Identities = 89/415 (21%), Positives = 174/415 (41%), Gaps = 39/415 (9%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS--- 58 +++ L + F G K +P + + P +A G G + K+IG+ E + Sbjct: 4 MSQRLFVDFMGKKLCSPIIVGAGPSTKSCSDIIEAAKFGAGAAIIKSIGWHADVEKTLKD 63 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG------EN 112 + +K ++ + +I P NL + D P + AS+ + Sbjct: 64 RKRYRWIKGYGTYLKSTYLCEILSKPYGCNLIKEVKSSSDIP---IYASVFYPALSNEHD 120 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 +W +L V AG D ++ +F + +V + + + CR+ + LP++ Sbjct: 121 IDRWIDLVSEVSNAGCDGVQLDFFYLDLRKL-NDDEVCFFVDAINRICRS----THLPVM 175 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK-------SS 225 K+ + D + K +D I+++ + ID+ K G P+ +G+ S Sbjct: 176 PKLNIAMDDDL-IENLLKNSLSDAYVFIDSINTEPYIDIWNK-GAPLFDGQLYNSQTNRS 233 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 S +G+A+ P Q++ D +S GG+E WED ++LGA+T+ +T+ + Sbjct: 234 GSVVAGEALLPFTFNMTQRLYRST---DKNLSAGGGLEHWEDIIRCIMLGASTVHLTSIL 290 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV--YPRINLDK 343 M+ G++ + D+ S +++YL Q + + ++ G++ + + + I+ I+ K Sbjct: 291 MRRGFKYIRDLNSSINNYLDKQHVEKISDIRGVSYSTNAGNTIIQQKPILDMRAIIDSSK 350 Query: 344 CVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEV 398 C CG C + + P+ C GC C +CP I L V Sbjct: 351 CNDCGVCE--------RFKVCDSFSVKPYDFINNCDGCTYCLALCPRNAISLIGV 397 >UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECL7_9ACTN Length = 302 Score = 216 bits (551), Expect = 1e-54, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 135/316 (42%), Gaps = 20/316 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 +++ F GVK NP ++ G ++ + G + K +PR + Sbjct: 1 MAVDFGGVKMQNPINTAAGTFGYGWQFQNFFDVSQLGAITTKGCAAEPWPGNPAPRMAEI 60 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 +G +N A E+ L +L +D +I + G + ++ + Sbjct: 61 PGGMINSVGLQNPGVAA--FARESGPWLEQLSKD--GCQVICQVAGHSVDEFVRALEMYV 116 Query: 125 EAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 E A E N SCP + + G+ +G +PE A ++ + P+ KM P ++ Sbjct: 117 ELCPWAAGYEINVSCPNIAAG--GAAMGSTPEGASSVMAACRKVTDKPLFVKMAP--VNV 172 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E+A A + GADG++ IN+++ + ID++ + G SG IA+R + Sbjct: 173 AEIAKALEAAGADGLSVINSIQGMA-IDVHTRKSR----VAKPKGGLSGPLCHHIAVRMV 227 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 ++ + D PI+G+GG+ T EDAAEF+L GA + V +A L Sbjct: 228 WEVA---QAVDIPINGVGGVMTGEDAAEFILAGATCVSVGMANFV-DPCASLKIAHELEA 283 Query: 303 YLADQGFDSLQEMVGL 318 + QG + E+VG Sbjct: 284 WAESQGVKDINELVGA 299 >UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 Tax=Dekkera bruxellensis RepID=A2VBP6_DEKBR Length = 442 Score = 216 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 75/337 (22%), Positives = 129/337 (38%), Gaps = 34/337 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L + G NP +++ E YD G+G V TI PRF L Sbjct: 109 LRVDLFGRTLANPIGMAAGFDK-QAEAMDALYDLGFGIVEVGTITPEPQFGNPRPRFFRL 167 Query: 65 VKEDT--GFIGFKNMEQIAEHP-----LEENLAALRRLKEDYP---DKVLIASI----MG 110 ++T G + ++ LE+ L K + K L +I G Sbjct: 168 NADETVINRYGLNSDGRLTILSRLRVRLEKYLKKSNACKTNNSFREGKSLFVNIGKNRNG 227 Query: 111 ENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR----- 165 + + AD + N SCP + EL+ K + Sbjct: 228 DTIDDYLVGVDTFAPY-ADALVLNVSCPSAPGVRDLQEKDVLLELLTKVREERDKVGANV 286 Query: 166 ---GSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 P++ K+ P++ + + ++A AK+ DGI NT + + + P+V Sbjct: 287 IDPARKPPIIVKVAPDLSEKEIADIADVAKKSKIDGILMSNTTTARPASLITKG---PVV 343 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQ 280 K G SG+A++ I+L+ + +R + + D + G GGI T +DA F GA+ ++ Sbjct: 344 QEK---GGLSGRAMRDISLKAFRTLRKYTKDSDLVLIGCGGIFTGKDAIAFAKAGASAIE 400 Query: 281 VTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 + T G I + + + L +G + E+VG Sbjct: 401 LYTSFAYRGPGIPDKIKDEIVQELKKEG-KTWMEIVG 436 >UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria RepID=PYRD_ROSCS Length = 367 Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats. Identities = 66/326 (20%), Positives = 121/326 (37%), Gaps = 33/326 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + + G++F +P +++ ++ G+ V T+ PR L Sbjct: 50 LMVEWAGLRFASPLGVAAGFDKR-ADLVDALALLGFSHVEVGTVTPRPQPGNPGPRLFRL 108 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + D I + + L A R +V++ +G+N E R V+ Sbjct: 109 PE-DMALINRLGFNSHGMVAVAKALRARRS------RRVIVGVNIGKNRDTPLE--RAVE 159 Query: 125 EAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLAK 174 + A D + N S P + EL+ + R P+ K Sbjct: 160 DYAATFVALAPLADYVAVNISSPNTPGLRRLHERAALEELLRELMRLNHGLLYPRPIALK 219 Query: 175 MTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 ++P+ + + EV A G A NT + + + G SG+ Sbjct: 220 ISPDETLDQIEEVVRAGCEAGVAAFIATNTTLAREGLRSR---------LANETGGLSGR 270 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + P A + I+ + P+ G+GG+ T +DA + GA +Q+ TG++ G I Sbjct: 271 PLAPRARQVIRAIYRLTRGTP-PVIGVGGVLTADDAYAHIRAGARLVQLYTGMVYAGPAI 329 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGL 318 ++ GL+ L GF S+ + G+ Sbjct: 330 AREIKRGLAQLLRRDGFVSVTQATGV 355 >UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacteria RepID=B7K1Y7_CYAP8 Length = 339 Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats. Identities = 67/332 (20%), Positives = 128/332 (38%), Gaps = 21/332 (6%) Query: 16 PNPFCLSSS-PVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTG---- 70 +P + S P+ + + D G VV + + H + T Sbjct: 13 KSPLVVGSCAPLTEDIDNLKRMEDAGAAAVVLHSFFEEQLRQERLELHHHLTYGTESFAE 72 Query: 71 FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADM 130 + + +I +E L +R+ KE D +I S+ G W + A+ +Q+AGAD Sbjct: 73 ALTYFPEPEIFHIGSQEYLNHIRQAKEMV-DIPIIGSLNGSTLGGWLDYAQQIQQAGADA 131 Query: 131 IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAK 190 +E N G +V Q+ + VK +P+ K++P +M +A Sbjct: 132 LELNIYYVPTDLDIPGGEVEQNY---LDILKNVKAALNIPVAIKISPYFSNMANMAKRLA 188 Query: 191 RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE 250 GADGI N +IDL P V S + +R+I + E Sbjct: 189 EAGADGIVLFNRFYQ-PDIDLENLEVYPNVL-------LSTPQALRLPMRWIAILYGRIE 240 Query: 251 LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFD 310 ++ GI D + +++GA QV + ++++G + + G+ ++ D ++ Sbjct: 241 AD---LAATSGIHHTTDVLKMVMVGAKITQVVSALLRHGIGYLSTLEQGMIRWMEDNEYE 297 Query: 311 SLQEMVGLANN-NIVPAEDLDRSYIVYPRINL 341 S+++M G + + +R+ + Sbjct: 298 SIKQMQGSLSQLHCPDPTAFERAQYMKALQTY 329 >UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydroorotate oxidase n=1 Tax=Streptococcus mutans NN2025 RepID=C6SRR7_STRMN Length = 330 Score = 216 bits (549), Expect = 2e-54, Method: Composition-based stats. Identities = 68/315 (21%), Positives = 122/315 (38%), Gaps = 14/315 (4%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVK 66 T F N ++ E A + G V KT A PR+ Sbjct: 25 TTIGSFDFDNCLMNAAGVYCMTREELAAIDHSEAGSFVTKTGTLEERAGNPQPRYADTKL 84 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 +G N+ + L + L++ K S++G + ++ + ++V+ + Sbjct: 85 GSINSMGLPNL------GINYYLDYVTELQKQPDSKNHFLSLVGMSPEETHTILKMVEAS 138 Query: 127 GADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 + E N SCP + + E ++ V T P+ K+ P D+ Sbjct: 139 KYQGLVELNLSCPNVPGKP---QIAYDFETTDQILSEVFTYFTKPLGIKLPPYF-DIVHF 194 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 AA + +N + SI N L + ++ K+ G G VKP AL + Sbjct: 195 DQAAAIFNKYPLTFVNCINSIGN-GLVIEDETVVIKPKNGFGGIGGDYVKPTALANVHAF 253 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 I G GG++T DA E +L GA+ +Q+ T + Q G +I + + L + Sbjct: 254 YKRLN-PSIQIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPQIFKRITKELKAIMT 312 Query: 306 DQGFDSLQEMVGLAN 320 ++G+++L++ G N Sbjct: 313 EKGYETLEDFRGKLN 327 >UniRef50_A7H8H3 Dihydroorotate dehydrogenase n=4 Tax=Anaeromyxobacter RepID=A7H8H3_ANADF Length = 328 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 64/339 (18%), Positives = 135/339 (39%), Gaps = 23/339 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF----IANEVS 58 +L + G+ P+P L+S + N E A G G VV +++ A+ + Sbjct: 1 MAELVTEYMGLALPSPLVLASCALSNRVENLEMAEGHGAGAVVLRSLFEEQLEGAASALE 60 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + + +++ H + L+ + R K + +IAS+ W + Sbjct: 61 EELLRGAESNPEARTYFPPQRVGPH---DYLSLVERAKRAL-EIPVIASLNCAAPGSWTD 116 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 AR +++AGAD +E N + G++V + AV++ +P+ K++P Sbjct: 117 YARDIEQAGADALEVNLYSVEADPTVSGAEVE---ARYLEVVAAVRQAVRIPIAVKLSPF 173 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + A G +G+ N +I L + +P + S + + Sbjct: 174 FSSLAHFATRLDGLGVNGLVLFNRFLQ-PDISLERMAALPTMTP-------SAPSEALVP 225 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR+I + ++ G+ + +L GA +Q+ + +M+ G + + + Sbjct: 226 LRWIALLHGRVRAH---LAASTGVYDAPGVLKQVLAGAQVVQLASTLMKNGIPHLGKVLA 282 Query: 299 GLSHYLADQGFDSLQEMVGLANNN-IVPAEDLDRSYIVY 336 G+ +L +G SL E+ G + + +R+ V+ Sbjct: 283 GIEDWLDRRGVSSLDELRGALSQREVSDPGAFERAQYVH 321 >UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria RepID=PYRD_THEFY Length = 377 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 124/331 (37%), Gaps = 29/331 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 +L + G +FP P L++ N A G+ V T+ PR Sbjct: 48 EPELRVRVFGREFPGPLGLAAGFDKNAR-GVAALTALGFSHVEIGTVTGQPQPGNPRPRL 106 Query: 62 DHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------ 113 LV + +GF N A LR + +++ +G+ + Sbjct: 107 FRLVADRAIVNRMGFNNEGSQAVS------ERLRAHRARRARDLIVGVNIGKTKVVPDSD 160 Query: 114 --QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS--TL 169 + AR + AD + N S P + L+ R + L Sbjct: 161 AVADYVTSARRFADL-ADYLVVNVSSPNTPGLRDLQATERLRPLLSAVRRTLDEAGRPDL 219 Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+L K+ P++ D + VA A G DGI A NT S + + P Sbjct: 220 PLLVKIAPDLADEDIDAVADLAVELGLDGIIATNTTVSRDGLATD-----PEEVAALGAG 274 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG +K AL+ ++++R R + +GGIET EDA + GA +Q TG++ Sbjct: 275 GLSGAPLKERALQVLRRLRARVGDR-LVLIAVGGIETPEDAWARIRAGATLVQGYTGLIY 333 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G + G++ GF S+ E VG+ Sbjct: 334 GGPLWPRRIHRGVAALARRDGFASIAEAVGV 364 >UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5A0_9ALVE Length = 471 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 124/338 (36%), Gaps = 26/338 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNC-YEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L GV+FP P L++ N + G G ++ PR Sbjct: 136 LKQVLFGVEFPRPVGLAAGFDKNGELLHLLTSSTLGNGFAEIGSVSKEPWPGNPRPRMFR 195 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQ-------QW 116 L + D I + L E L ++ L I + + Sbjct: 196 LAR-DGAVINRMGLNNRGAAALREKLRSMSTLLNGTRHTPPIGVSITKTPSPTIENDAAI 254 Query: 117 EELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLA 173 ++ E A I+ N SCP D+ +L+ + P+L Sbjct: 255 ADIVASFDEVAPYAAYIDVNISCPNTAEGKTFEDLEALEKLLGALLTWRRDNYPDKPVLV 314 Query: 174 KMTP--------NIGDMCEVALAAKRGGADGIAAINTVKSI-TNIDLNQKIGMPIVNGKS 224 K++P + + A G DG INT+ +++L++ +G + Sbjct: 315 KLSPPPAEADDTYYEGVSRMVRKAVELGVDGFVMINTIADRGDDLNLDRSVGD---SNHG 371 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SGK V+ A+ ++ + + PI G GG+ T +DA + GA+ +QV TG Sbjct: 372 EKGGISGKPVRQRAINLVRHVYKVTAGK-VPIIGCGGVFTAQDAYRLIRNGASLIQVYTG 430 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 ++ G + D+ GL+ L G+ ++ E VG+ + Sbjct: 431 MIYEGPWVFRDINCGLAELLRKDGYSNVHEAVGVDVKS 468 >UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NV76_9GAMM Length = 367 Score = 215 bits (547), Expect = 3e-54, Method: Composition-based stats. Identities = 69/332 (20%), Positives = 120/332 (36%), Gaps = 32/332 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L+ G+ F +P L++ + + G+ + T+ PR Sbjct: 49 PRLAQELWGLHFAHPVGLAAGFDKDG-QALKSLASVGFAFLELGTVTPRPQPGNPGPRIF 107 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE----- 117 ++ I + + RL P V + +G+N + Sbjct: 108 RYPQQ-RAVINRLGFPSQGGSAVAD------RLAATLPLTVPLGINIGKNRETPLTAAVG 160 Query: 118 ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAK 174 + L+Q+ G AD I N S P D L+++ A ++ P+L K Sbjct: 161 DYRALIQQLGPFADYISINVSSPNTPELRRLQDPQSLRPLLQELREARQKLQRQPPLLLK 220 Query: 175 MTPNIGDMCEVALAAK----RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 + P++ ALAA + DG A NT + + G S Sbjct: 221 IAPDLAPDEVTALAALAQEPQPLLDGFIATNTTLGRPSD----------WPHPAEAGGLS 270 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G +K A I Q+ PI G+GG+ T +D + + GA+ +Q+ T ++ G Sbjct: 271 GAPLKRRANGIIAQLYRASS-GRLPIIGVGGVATAQDVLDKIEAGASLVQLYTALIYEGP 329 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 +V+ + L L D+G D L +VG + Sbjct: 330 DLVQQITDALPELLTDRGVDHLGALVGRRAEH 361 >UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PC95_9FIRM Length = 799 Score = 214 bits (546), Expect = 4e-54, Method: Composition-based stats. Identities = 104/434 (23%), Positives = 178/434 (41%), Gaps = 36/434 (8%) Query: 2 LTKDLS--ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSP 59 + +D+ + GV F NPF ++S P + +TGW K + A ++ Sbjct: 1 MVEDIRIPVKVGGVTFKNPFYVASGPTTKNVRQLQRIEETGWAAASIK-LSIDPAPYINR 59 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG---ENEQQW 116 + + + ++T + F +++ +E L + K+ D +L+A+I W Sbjct: 60 KPRYGLFDETNALAFTAEKRLT---FQEGLTLIEDAKKVLSDLILMANITYAGDRGAAGW 116 Query: 117 EELARLVQEAGADMIECNFSCPQM-------------TSHAMGSDVGQSPELVEKYCRAV 163 +A+ + GAD+IE N CP M TS G+ +G+ +V + RA+ Sbjct: 117 VNMAKQFEAVGADIIELNMCCPNMSYNVSLSSGGAASTSQQTGASLGRQAGVVAEIVRAI 176 Query: 164 KRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI-VNG 222 K+ +P+ K+TP G++ +VA A GAD + + + IDLN + Sbjct: 177 KKEIHIPLFVKLTPEGGEVAQVAAALYAAGADAVGSTGNRLGLPPIDLNDPGRAVYHLQD 236 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 + S+S Y G +KP+A R ++R + + + GGI W A E +L G L V Sbjct: 237 EISMSCYCGSWLKPLAQRDAYEIRKVCGM-EPKMMAAGGITDWRSAVEMVLCGGNLLGVC 295 Query: 283 TGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLD 342 + GY IV M GL Y+ G+ S+ + G + + A +L + Sbjct: 296 AETLISGYDIVRPMIRGLKDYMDTHGYRSIDDFCGKVVSAVRTAPELTLHDGYAHIREPN 355 Query: 343 KCVGCGRCYISCY-----DGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGE 397 G C +C Q++ + T K V C ++CP C E Sbjct: 356 L---AGPCKAACPHHVPVQAYVQSIARGDFHHAYELITGKGVLQGACAYICPHPC----E 408 Query: 398 VKFKKGEKEHPVTL 411 +G PV + Sbjct: 409 DACVRGRTGRPVAI 422 Score = 45.8 bits (107), Expect = 0.003, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 23/63 (36%), Gaps = 10/63 (15%) Query: 343 KCVGCG------RCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 +C+ CG C C D + +CV C +C + CP IE+ Sbjct: 741 RCLNCGCGEGCQLCKTICTDFAP----LVTGPDQLAIDRTQCVACGMCYNRCPNKNIEML 796 Query: 397 EVK 399 +K Sbjct: 797 PIK 799 >UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=Q7N0H1_PHOLL Length = 289 Score = 214 bits (546), Expect = 4e-54, Method: Composition-based stats. Identities = 77/301 (25%), Positives = 123/301 (40%), Gaps = 26/301 (8%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 G+K NP + S + + + + G G VV KTI PR + L E Sbjct: 11 DVLGMKIKNPIIVGSGLLSDQAKNIRQFIAHGAGAVVTKTI--------YPRSEKLHTEK 62 Query: 69 TGFI--GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 T G N ++ +E L LR KE+ +I SI E+ + LA + Sbjct: 63 TYLFSTGMLNNTTYSKKTVEYWLTLLREFKEE--QLPVIVSIHAESPEALASLAVRISAV 120 Query: 127 GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVA 186 +E SC +PE V Y + VK + P K++ ++ Sbjct: 121 TDAPLELGISCLHADDFT-----EDTPERVFNYTKVVKERTNTPFAVKLSLG-DNLYGRV 174 Query: 187 LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 AA GGAD I +T+ I N + + + + GYSG +KP+ L I +R Sbjct: 175 QAAVEGGADAITLSDTISGIAFDTANGEALL------NGVCGYSGPGIKPMVLAAIYNLR 228 Query: 247 THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD 306 PI G GG++ D E+LL GA T+QV T + ++ Y+ ++ + + + Sbjct: 229 KRG--VTIPILGSGGVQDGNDVHEYLLAGANTVQVYTALHRHMYKTLQRIVHEYTQVMTS 286 Query: 307 Q 307 + Sbjct: 287 E 287 >UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular organisms RepID=PYRD_NATPD Length = 350 Score = 214 bits (545), Expect = 5e-54, Method: Composition-based stats. Identities = 75/321 (23%), Positives = 120/321 (37%), Gaps = 26/321 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L + G FPNP +++ N E+ G+G V + A PR Sbjct: 48 PRLRVDAFGQTFPNPVGVAAGFDKN-AEIPDALGALGFGHVEVGGVTAEPQAGNPRPRMF 106 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIA-SIMGENEQQWEELAR 121 L + D I + E LAA P V I S N+ + Sbjct: 107 RLAE-DRALINRMGFNNDGADIVGERLAA---TDCRVPVGVNIGKSKSAANDDAEADYQY 162 Query: 122 LVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + G D N S P QS + +E ++ P+L K++P++ Sbjct: 163 TYERVADGGDYFVVNVSSPNTPGLREL----QSRDRLESILGTLQDDGASPLLVKLSPDL 218 Query: 180 GD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 D + + + G DGI A NT ++ + G SG + Sbjct: 219 TDAAIEDAIEVVEDLGLDGIIATNTT--------TKRPASLHSDAADEEGGLSGAPITDE 270 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 + ++ + D PI G+GGI+ E A E + GA+ +Q+ TG++ G I D+ Sbjct: 271 STDIVRFIAKRT---DKPIVGVGGIDDAESAYEKIRNGASVVQLYTGLVYEGPTIARDIN 327 Query: 298 SGLSHYLADQGFDSLQEMVGL 318 GL L GF S+++ VG+ Sbjct: 328 RGLLKLLERDGFASVEDAVGV 348 >UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacteria RepID=PYRD_CYAP8 Length = 377 Score = 214 bits (544), Expect = 7e-54, Method: Composition-based stats. Identities = 63/329 (19%), Positives = 114/329 (34%), Gaps = 23/329 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L T G+ F NP L++ G+G + PR Sbjct: 60 RLKQTLWGLTFNNPVGLAAGCDKEGIAA-GIWSHLGFGFAELGAVTLHPQPGNPRPRLFR 118 Query: 64 LVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQW 116 L + +G N E L + + P + I + +++ + Sbjct: 119 LPHDKAVLNRLGANN------QGAEIMAQTLAEIWQRSPRNIPIGINLCKSKITPLDEAA 172 Query: 117 EELARLVQ--EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 ++ E AD N S P + Q +++ A P+ K Sbjct: 173 QDYVGSFSYLENQADYFVVNVSSPNTPGLRSLQEGEQLNSILQALQAA--NQHQKPLFVK 230 Query: 175 MTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 ++P++ + + + A+ GI A NT + + G SG Sbjct: 231 ISPDLEEEAILTIIELAQTHCLAGIIATNTTIKRDRLTTQILPETGN-KIQEEAGGISGL 289 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 ++ + I + + + PI G+GGI T +DA ++ GA+ LQ+ TG + G I Sbjct: 290 PIRDRSTEIIGFIYQKTQGK-LPIIGVGGIFTPDDAWNKIIAGASLLQLYTGWIYQGPWI 348 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANN 321 + D+ GL L G + + VG+ + Sbjct: 349 IPDIVRGLGDKLKQLGLSHISQAVGINHK 377 >UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococcus RepID=Q5HL43_STAEQ Length = 354 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 131/321 (40%), Gaps = 25/321 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ G+ F NP L++ +C E+ + G+G + I PR L Sbjct: 49 LTQHIHGISFDNPIGLAAGFDKSC-EVPKALENIGFGAIELGGITPKPQPGNPKPRMYRL 107 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN-EQQWEELAR 121 +++D +GF N + + L+ LR P + + + E ++++ + Sbjct: 108 LEDDALINRMGFNN------KGMNKALSNLRNHSCSIPVGLNVGVNKTTSYENRYQDYIK 161 Query: 122 LVQEAGADM--IECNFSCPQMTSHAMGSDVGQSPELVEKYCR-AVKRGSTLPMLAKMTPN 178 ++ D+ N S P + D + L + K +P+ K+T + Sbjct: 162 VIDTFKNDVSFFTVNISSPNTENLQNFHDEDEFSMLCDALNSFKAKNNINVPIFLKLTSD 221 Query: 179 IG-DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + D + L + DG+ NT + ++ KI G SG+ + Sbjct: 222 MELDGFKKILPSITDTFDGVMLANTTRQRDGLNSKNKIQE---------GGLSGRPLFQR 272 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 L+ ++ +F I G GGI + EDA + L GA+ LQ+ + ++ G + + M Sbjct: 273 NLQLVKYAYQQTR-GNFLIIGTGGIFSSEDAIKMLRNGASLLQIYSSLVIEGPGLTKKMN 331 Query: 298 SGLSHYLADQGFDSLQEMVGL 318 ++HYL G+ ++ +++GL Sbjct: 332 KEIAHYLTRHGYANVSDIIGL 352 >UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6B3_9ACTN Length = 309 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 67/323 (20%), Positives = 127/323 (39%), Gaps = 22/323 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + + G+ NP ++ + + G + K A +PR Sbjct: 4 TPVSMEVNLGGIHMKNPVNTAAGTFAFGQQFEKFYDVSQLGAITTKGASIKPWAGNPAPR 63 Query: 61 FDHLVKEDTGFIGFKNME-QIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + +G +N + L L++ + +I + G + ++ Sbjct: 64 MCEVTSGIINSVGLQNPGVNGLINTAGAYLTGLQQ-----KNCQVICQVAGHSIDEYVAA 118 Query: 120 ARLVQE--AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + +E + A E N SCP + G+ +G +P+ + R ++ + P+L KM P Sbjct: 119 LEVFEEKASFAAGFEINISCPNIACG--GAAMGSTPQGAAEIMRRLRPLTKRPLLVKMGP 176 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 ++ E+A A + GAD ++ IN++ + ID G+SG A+ PI Sbjct: 177 --VNIPEIARALESEGADALSLINSIPGMA-IDTTTYKSK----LSRPTGGFSGPAIHPI 229 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 A+R + + + P+ GIGGI T +AAEF+L GA + V + + Sbjct: 230 AVRMVWEAHKAVK---IPLCGIGGITTGLEAAEFILAGATAVSVGLANLY-DPMSAPRIL 285 Query: 298 SGLSHYLADQGFDSLQEMVGLAN 320 L + QG + +++G Sbjct: 286 HELCDWAQKQGVTRISDLIGACK 308 >UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhabditis RepID=A8WW30_CAEBR Length = 426 Score = 211 bits (538), Expect = 3e-53, Method: Composition-based stats. Identities = 70/350 (20%), Positives = 130/350 (37%), Gaps = 47/350 (13%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 +L G +F NP L++ + + A ++G+G + ++ PR Sbjct: 88 PELKCELFGREFRNPIGLAAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNNRPRVF 147 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALR--RLKEDYPDKVLIASIMGENEQQWEELA 120 L++ D G I + + + + R + E Y +G+N+ E A Sbjct: 148 RLLE-DEGVINRYGFNSDGVGRVHQRVRSARDAWVPEQYAY---FGVNLGKNK--LTEDA 201 Query: 121 RLVQEAG-------ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK--RGSTLP- 170 +L E G D + N S P +L+ ++ + P Sbjct: 202 KLDYEIGVNYFAPHCDYLVLNVSSPNTPGLRSMQKKSDLEKLLAYVKESLDMHKLEKRPQ 261 Query: 171 MLAKMTPNI--GDMCEVALAA--KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 + K+ P++ +M ++A K+ G DGI NT + + + K+ Sbjct: 262 IFLKIAPDLIDSEMKDIAHVVTNKKFGVDGIIVSNTTIARPDYLKS--------ENKAET 313 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLL------------- 273 G SG V+ I+ I++M + PI G GG+ + EDA E + Sbjct: 314 GGLSGAPVREISTECIRKMYKLTNGQ-IPIIGCGGVFSGEDAYEKIRYNRRNAIDSNYNI 372 Query: 274 --LGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 G + +Q+ + + G+ ++ + LS L GF + E VG + Sbjct: 373 FSAGGSLVQLYSAFVYEGFPVIGKIKRELSELLKRDGFAHVSEAVGADHR 422 >UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyrus kandleri RepID=Q8TXU6_METKA Length = 318 Score = 211 bits (538), Expect = 3e-53, Method: Composition-based stats. Identities = 86/321 (26%), Positives = 140/321 (43%), Gaps = 16/321 (4%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKE 67 + G ++ +P +S + A G + KT+ E P + Sbjct: 4 VEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVT-ESPREGHPGPVFVDYL 62 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 D G+ N + + + + ++++ D + AS+ + + ++ LAR Sbjct: 63 DEGYA--LNAMGLPNPGPDRMVVEIEEFRDEF-DVPVYASVAADGPEGFKRLARAFSGV- 118 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--MCEV 185 AD +E N SCP G+++G PE V + A R P+ K+TPN+ + EV Sbjct: 119 ADGLELNVSCPH-AGKGYGAELGSDPEAVAEITEAAVRAFDGPVSVKLTPNVDRETLLEV 177 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A AA GA+ + A+NT+ IDL + P++ + G SG A+KPIALR + + Sbjct: 178 AAAAIDAGAEALTAVNTLGPGLRIDL--RTASPVLGA--GVGGLSGPALKPIALRVVADL 233 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 + I G+GGI ED EFL GA +QV T + + D+A SH L Sbjct: 234 ALEFG-EEVEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFG---DIAMETSHILK 289 Query: 306 DQGFDSLQEMVGLANNNIVPA 326 + G+D +E +G A Sbjct: 290 ELGYDGPEEAIGAALPEYRER 310 >UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae RepID=C9M6H2_9BACT Length = 317 Score = 211 bits (537), Expect = 4e-53, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 135/329 (41%), Gaps = 21/329 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ G+ +P ++S E A Y G V K I R Sbjct: 7 LTCHVGGLDLTSPLVIASGIWPYEKEYWAGEYLDFAGAVCSKAITADPRPGNPGTRVWET 66 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 IG +N + L LR K L+ ++ E+ E + ++ Sbjct: 67 PCGMLNSIGLQNEGAGS--FFGGTLGRLRSY-----GKPLLLNVSMESSSDLERILDAME 119 Query: 125 EAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 D +E N SCP + M G P L + + V+R + P+ K+TP D Sbjct: 120 PVAPSVDCVELNVSCPNVDQGCM--SWGVDPALTAQAVQQVRRRWSGPLWVKLTPQAPDP 177 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 C VA AA+ GA + NT ++ P + ++G SG A+ P+ALR + Sbjct: 178 CAVAKAAQDAGASALVVANTWLGAA---IDTVKARPAFD--RVVAGLSGPAIFPLALRMV 232 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 Q+ D P+ G GG+ + + A L+ GAA ++V + + ++E +A GL Sbjct: 233 WQV---CGAVDIPVVGCGGVASADSAVAMLMAGAAAVEVGMALFS-DFSVLERIARGLEE 288 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDR 331 ++ +GF S+ E+VGLA + E + R Sbjct: 289 EVSRRGFQSVGELVGLARPDRDLQERMRR 317 >UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobacterales RepID=PYRD_HELPG Length = 351 Score = 210 bits (535), Expect = 6e-53, Method: Composition-based stats. Identities = 72/332 (21%), Positives = 125/332 (37%), Gaps = 42/332 (12%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L G+ FPNP L++ N M G+G + T+ PR Sbjct: 48 PKLENEILGLNFPNPLGLAAGFDKN-ASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 ++E++ +GF N + R P K I +G+N+ E A Sbjct: 107 RHIEEESLQNAMGFNNYGAVLGA---------RSFNRFAPYKTPIGINLGKNKH--IEQA 155 Query: 121 RLVQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 +++ A D N S P + Q+ V + K + P+ Sbjct: 156 HALEDYKAVLNQCLNIGDYYTFNLSSPNTPNLRDL----QNKAFVNELFCMAKEMTHKPL 211 Query: 172 LAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ DM E+ +A GA GI A NT I +V + G Sbjct: 212 FLKIAPDLEIDDMLEIVNSAIEAGAHGIIATNTT-----------IDKSLVFAPKEMGGL 260 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + + +++ + +S +GGI ++A E + +GA+ LQ+ + + G Sbjct: 261 SGKCLTKKSREVFKELAKAFFNKSVLVS-VGGISDAKEAYERIKMGASLLQIYSAFIYNG 319 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 + +++ L L GF S++E +G Sbjct: 320 PNLCQNILKDLVKLLQKDGFLSVKEAIGADLR 351 >UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UHA6_RHOBA Length = 359 Score = 210 bits (534), Expect = 8e-53, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 137/341 (40%), Gaps = 21/341 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + +L ++ G++ +P + + P+ E + G G +V +I + +V R Sbjct: 13 MPSELITSYLGMQLESPVVMGACPLTTQSEAVRQIVAAGAGAIVLPSI---LQEQVMHRM 69 Query: 62 DHLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + G I G++ + E L + RLK +IAS+ G + QW + Sbjct: 70 IK-ATDPFGAIERSGYQPQQDKYNGGTEAYLRTISRLK-GICSVPVIASMNGSSAGQWLQ 127 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A+ ++ AGAD +E N S +D+ + R V+ +P+ AK++ Sbjct: 128 YAKEMESAGADALEFNLQQAVFDSKETSNDIE---ARMCDLIRQVRELVVIPVAAKISQR 184 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 ++ +A ++ G G+ + D++ +N + S + G ++ I Sbjct: 185 YTNLSSMATQLRQVGVAGLVL---FTHMPQWDVSTDRMHWTINWELSPTNSIGGILEGI- 240 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +R + I+ GG+ EDA + ++ GA + VT+ + + G + D+ Sbjct: 241 ------VRARAGDQAISIAASGGVSNSEDAIKAMIAGADVVMVTSAVYRRGPDAIRDIVD 294 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRI 339 G+ ++ F +LQ+ + E R + P Sbjct: 295 GIERHVESSRFRTLQDFRAACPRDHAGDEKSVRLEYIDPLT 335 >UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular organisms RepID=PYRD_RHORT Length = 367 Score = 210 bits (534), Expect = 9e-53, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 130/329 (39%), Gaps = 33/329 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ + G +F NP L++ N E+ +D G+G V T+ A PR L Sbjct: 44 LACSLWGRRFANPLGLAAGFDKNG-EVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRL 102 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEEL 119 ++ +GF N +E A R + + ++ +G+N+ + Sbjct: 103 TQDRAVINRMGFNN------QGMEAMAARFVRAR----PRGVLGINLGKNKTTEDAAGDY 152 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR---GSTLPMLAK 174 + + AD + N S P L+ + A+ G P+L K Sbjct: 153 EAGIAKLAPLADYLVINVSSPNTPGLRALQGREPLSLLIARARAALDAACPGLRPPLLLK 212 Query: 175 MTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D M ++A A GG DG+ NT + ++ G G SG Sbjct: 213 VAPDLTDEDMADIAEVALGGGLDGLICTNTTIARPKSLVSDHAG--------ETGGLSGL 264 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 ++ A + I ++ + P+ G+GGI +A + GA+ +Q+ + ++ G + Sbjct: 265 PLRYRARQVIARLYGLTK-GALPLIGVGGIGDGAEAYARIRAGASLIQIYSALVYEGPGL 323 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANN 321 V + L+ L GF S+ E VG + Sbjct: 324 VGRIKRDLAQRLRADGFASVAEAVGADHR 352 >UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella benthica KT99 RepID=A9D5Y9_9GAMM Length = 334 Score = 210 bits (534), Expect = 9e-53, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 126/321 (39%), Gaps = 14/321 (4%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 K +S V + +S P + + ++ K+ PR+ Sbjct: 22 KRISTRIAQVPLASFIFNASGPRCTEEDELNLLGASASAAIMTKSCTLEPRQGNAEPRYQ 81 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L +G N+ E L L++ +K ++ S+ G + + + Sbjct: 82 ALPLGSIQSMGLPNL---GYQAYLEMLPRLKQAISPQTNKPIVVSVSGFSLADNLTMVKA 138 Query: 123 VQEAGADMIECNFSCPQMTSH-AMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP--NI 179 Q + AD+IE NFSCP + +G D Q+ +E+ C + + P+ K+ P + Sbjct: 139 FQASCADLIEVNFSCPNIEGKPQVGYDFEQTERALEQLC----QLGSKPIGLKLPPYFDF 194 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 +A K+ I IN+V + ID + I+ K G G +KPI L Sbjct: 195 SHFITMANIIKKFPVRFITCINSVGNTLVIDPETESA--IIKPKGGFGGLCGDYIKPIGL 252 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 ++ I G+GGI+T DA E+LL GA+ +QV T + G + +A Sbjct: 253 ANVRAFSQLLP-SSIDIIGVGGIKTGTDAFEYLLAGASAVQVATCFEKEGIECFDRIAKE 311 Query: 300 LSHYLADQGFDSLQEMVGLAN 320 L +A + + S+ G Sbjct: 312 LDSIMAAKQYSSIAAAKGKLK 332 >UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neorickettsia RepID=Q2GEM2_NEOSM Length = 348 Score = 209 bits (533), Expect = 1e-52, Method: Composition-based stats. Identities = 74/324 (22%), Positives = 116/324 (35%), Gaps = 31/324 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L CG+ F NP +++ N E G+G + T+ SPR L Sbjct: 43 LESRVCGLHFKNPIGIAAGFDKN-AECVTALRRVGFGFIELGTVTLKPQKGNPSPRLFRL 101 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN------EQQW 116 ++ +GF N + L +L++ L +I G+N + Sbjct: 102 PQDGAIINRLGFNN------KGIAYFLKSLKKAMTHMDLPPLGVNI-GKNAVSSNAVSDY 154 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 LA V AD I N S P S V EL+ AV GS + + K+ Sbjct: 155 ARLAAYVSSV-ADYITLNISSPNTVSLRDMQKVEILEELLIAVKAAV--GSNVRIFIKVA 211 Query: 177 PNIGDMCE--VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ + E + A + GI NT K G SG + Sbjct: 212 PDLAEGAEVGIISLALKHKVAGIIVSNTTIGC--------RESLHSKHKVEYGGLSGTPL 263 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 ++ +++M + G GGI E A + GAA +Q T +G+ ++ Sbjct: 264 FKLSTGLLRKMYRCTN-GELVFIGCGGISDAETAYAKIRNGAALIQAYTSFTYHGFGLLN 322 Query: 295 DMASGLSHYLADQGFDSLQEMVGL 318 + L L GF S+ E VG+ Sbjct: 323 QIKKDLVQRLKADGFSSVSEAVGV 346 >UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidobacteriaceae RepID=D2RBF2_GARVA Length = 333 Score = 209 bits (533), Expect = 1e-52, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 134/302 (44%), Gaps = 21/302 (6%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYD-TGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 GVK+ N +S C + YD + G + K + SPR Sbjct: 37 TQVAGVKWKNMVGTASGTF--QLAACRRFYDVSQLGAICTKGVSPVPWEGNPSPRTAESP 94 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 +G +N +H L + L L+++ ++I ++ G ++ + ++ + + Sbjct: 95 SGMVNAVGLQNPG--VDHYLVDELPKLKKM-----GALVITNVAGHSDDDYAQVVEKLAD 147 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 + ADM+E N SCP +T M VG P + + + ++ + PM+ KMTPN+ D+ + Sbjct: 148 SAADMLEINVSCPNVTHGGM--SVGTDPVALHRLIKRLRAMTDKPMIVKMTPNVTDIVSI 205 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 AA GAD ++ INT+ + ID+ + G PI+ ++ G SG A+ PI L F+ ++ Sbjct: 206 CKAAVDAGADALSMINTLVGL-RIDI--RTGEPIIANRT--GGVSGPAIFPIGLGFVWRV 260 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 R G I++ E A E+L GA ++V + +A L L Sbjct: 261 RQAMPDIPIIGIGG--IDSGEKALEYLYAGANAVEVGAAALV-DPTAPIRIARELDDLLD 317 Query: 306 DQ 307 + Sbjct: 318 SR 319 >UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus sp. RS-1 RepID=PYRD_ROSS1 Length = 361 Score = 209 bits (532), Expect = 1e-52, Method: Composition-based stats. Identities = 73/326 (22%), Positives = 125/326 (38%), Gaps = 33/326 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++ + G+ F NP +++ ++ G+G + T+ PR L Sbjct: 52 LAVDWSGLHFANPVGVAAGFDKRA-DLVDGLALLGFGHIEVGTVTPRPQPGNPRPRLFRL 110 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + DT I +A R L+ V++ +G+N E R V+ Sbjct: 111 PE-DTALINRLGFNSPG------MVAVARALRARRSRDVIVGVNIGKNRDTPLE--RAVE 161 Query: 125 EAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPMLAK 174 + A D + N S P + L+ + R + P+ K Sbjct: 162 DYVATFVALAPIADYVAVNISSPNTPGLRRLHERAALETLLHELTRLNRALPHPRPIALK 221 Query: 175 MTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 ++P+ + V A G A NT + DL+ ++ + G SG+ Sbjct: 222 VSPDETPDQLEAVVRAGCDAGIAAFIATNTT--LARDDLHSRLAI-------ETGGLSGR 272 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + A + I + P+ G+GGI T EDA + + GA +Q+ TG++ G I Sbjct: 273 PLTQRARQVIGAIYRLTH-GAPPVIGVGGIATAEDAYQHIRAGARLIQIYTGMVYAGPAI 331 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGL 318 D+ GL+ L GF SL+E VG+ Sbjct: 332 ARDIKQGLARRLRRDGFTSLEEAVGV 357 >UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria RepID=PYRD_CHLAA Length = 363 Score = 209 bits (532), Expect = 2e-52, Method: Composition-based stats. Identities = 71/316 (22%), Positives = 122/316 (38%), Gaps = 37/316 (11%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 + L T CG+ FPNP L++ + + A A G+G V T+ PR Sbjct: 58 QRLQRTVCGIPFPNPVGLAAGMDKDGVAIPAWAA-LGFGFVEVGTVTHHPQPGNPRPRLF 116 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 L +++ +GF N + RRL P + + +G+++ Q Sbjct: 117 RLPEQEALINRMGFNNQGAAS---------LARRLARLQPAPIPVGVSIGKSKITPLEQA 167 Query: 116 WEELARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKY------CRAVKRGS 167 ++ ++ A I N S P D Q L+ + Sbjct: 168 IDDYRASFRQLFPYAAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRG 227 Query: 168 TLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNID-LNQKIGMPIVNGKS 224 P+L K+ P++ D + EV G GI A NT S + ++ ++ + Sbjct: 228 PRPLLVKIAPDLSDTAIEEVLTVCADHGVAGIIATNTTISREGLTGVDPRLA-------A 280 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG+ + AL ++ + R PI G+GGI T +D L GA+ +Q+ TG Sbjct: 281 EAGGLSGRPLIARALHVVRLIARLTGNR-LPIIGVGGIHTPDDGLRMLEAGASLIQIYTG 339 Query: 285 IMQYGYRIVEDMASGL 300 ++ YG + + + Sbjct: 340 LVYYGPLLPRRINRAI 355 >UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Schizosaccharomyces RepID=PYRD_SCHPO Length = 443 Score = 209 bits (531), Expect = 2e-52, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 122/341 (35%), Gaps = 47/341 (13%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L++ G KF NP L++ + + + G+ + ++ PR+ Sbjct: 103 PSLAVEVWGKKFCNPIGLAAGFDK-QADAISGLLNFGFSYLEIGSVTPKPQPGNPKPRYF 161 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRR--LKEDYPD------------------- 101 L K D I I + + R + + P Sbjct: 162 RL-KPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPAVLG 220 Query: 102 --KVLIAS-----IMGENEQ--QWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVG 150 + LI + +G+N+ + E+ V+ G AD++ N S P Sbjct: 221 VPRSLIPNKFLGINLGKNKNGNEIEDYVEGVRTFGNFADILVINVSSPNTPGLRNLQKKS 280 Query: 151 QSPELVEKYCRAVKRGSTL--PMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSI 206 L+ + ++ P+L K+ P++ ++ ++A K+ DG+ NT Sbjct: 281 ALSTLLTAVVSERNKLNSPHPPVLVKIAPDLNEEELTDIADVLKKCKIDGVIVGNTTVQR 340 Query: 207 TNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWE 266 + + G SG +KPIAL ++ +R H D PI G GGI + + Sbjct: 341 PKTLKST-------SHVEETGGLSGPPLKPIALNTLRTLRKHLS-SDIPIIGCGGISSGK 392 Query: 267 DAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 DA E+ GA +QV T + G I + + L + Sbjct: 393 DAIEYARAGATMVQVYTALGYDGPVIAHKIKQEILAELKGK 433 >UniRef50_C2MA24 Dihydroorotate dehydrogenase 2 n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MA24_9PORP Length = 327 Score = 209 bits (531), Expect = 2e-52, Method: Composition-based stats. Identities = 66/341 (19%), Positives = 142/341 (41%), Gaps = 18/341 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DL+ + G+ NP SS + + G G V+ K++ + + + Sbjct: 1 MVDLTSHYGGIALRNPIIAGSSGLTASLQQIKALAQAGAGAVILKSLFEEQIEATALQAE 60 Query: 63 -HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + + + +H +E+ L +R K+ D +IAS+ +WE A+ Sbjct: 61 AEMATSYPEGLDYM-LHYTRQHEVEKYLDLIREAKQAI-DIPVIASVNCYRGGEWEAFAQ 118 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 +QEAGAD +E N + GSD+ Q + ++ R +P++ K++ + Sbjct: 119 SIQEAGADALELNVMRIETDPAQRGSDLEQE---LVDLAISITRTVQIPVVFKISDRFTN 175 Query: 182 MCEVALAAKRGGADGIAAIN-TVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + +A + G G+ N + ++ NI+ + + P+++ + L+ Sbjct: 176 ILYLAQELVKSGVKGLTCFNKSWQTDINIETLEIVQGPVISTGHELYN---------TLK 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + +L +S GG+ + + LL+GA+++QV + + Q+G + M L Sbjct: 227 YTGLL--TGKLPQLAVSASGGVMDYAGVVKSLLVGASSVQVVSALYQHGASYLTKMLEEL 284 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINL 341 + ++ G+ S+ E G N + ++L + Sbjct: 285 TQWMTQHGYRSIDEFRGNLNASKQSDQELYMRSQFMRYFSS 325 >UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira RepID=Q056I9_LEPBL Length = 384 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 118/327 (36%), Gaps = 30/327 (9%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTI-GFFIANEVSPRF 61 + L G++F NP + + E+ G+G + TI G + PR Sbjct: 66 SDRLKTRVAGIEFENPLGMGAGFDKTG-ELYPFLSRMGFGHIEIGTITGKSQPGNLKPRV 124 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-------- 113 + D I E +A ++ K G+ + Sbjct: 125 FRYPE-DQALINHMGFNNPGADSAERIIAPQKKRKIR-------GINAGKTKIISEEKAV 176 Query: 114 QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 + + + + AD N S P L++ + + +P+ Sbjct: 177 EDYIYTLKKLSPY-ADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFV 235 Query: 174 KMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K P++ D+ + ++ DG+ NT ID + P V + G SG Sbjct: 236 KFAPDMETKDLEALLESSLSLKIDGVVLTNTT-----IDKSSLKAYPNVEKE---GGLSG 287 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 +K + F++ + R PI G+GGI++ + A E +L GA +Q+ TG + G Sbjct: 288 VPLKNRSTEFVRVAYRILK-RRIPIIGVGGIDSEKAALEKILAGADLIQIYTGYIYQGPF 346 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGL 318 + + L +L +Q ++ ++VG Sbjct: 347 LPLKILEFLDRFLKEQDLKTVSDLVGK 373 >UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G8S8_PHATR Length = 456 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 140/352 (39%), Gaps = 38/352 (10%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 S + G FPNP L++ + E+ + D G+G V T+ PR LV Sbjct: 92 SNSVFGKTFPNPIGLAAGFDKDG-EVVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRLV 150 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALR------RLKEDYPDKV------------LIAS 107 + D G I +E+NL + R K +P + L+ Sbjct: 151 E-DLGIINRYGFNSQGASTVEKNLKSFRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVGV 209 Query: 108 IMGENEQQWEELARLVQE-----AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 +G+N+ + + V + AD + N S P L+ Sbjct: 210 NIGKNKNSLDAIGDYVCNIRQLSSLADYMVLNISSPNTAGLRDLQQANSLRVLLTTCLTT 269 Query: 163 VKRGST-LPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 + +P+L K+ P++ D + ++A G DGI NT L++ Sbjct: 270 RNEMTHRVPLLVKLAPDLTDEELDQIANVCLEVGIDGIIITNTTNHRPADLLSK------ 323 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 + I G SGK VK + I+++ + + PI G+GG+ + DA E L GA+ + Sbjct: 324 --HRGEIGGLSGKPVKDQSTECIRRLFRLTDGK-IPIIGVGGVGSGHDAYEKLKAGASLV 380 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331 QV + ++ G ++ + L+ + + G S+ +++G + +I + +R Sbjct: 381 QVYSMMVYQGPGVISRIRHDLATLMLENGQRSIVDVIGADHEDIFWRKREER 432 >UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, putative n=3 Tax=Agaricomycotina RepID=Q5KK62_CRYNE Length = 591 Score = 207 bits (528), Expect = 5e-52, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 122/336 (36%), Gaps = 44/336 (13%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 +L G+ NP +++ E +D G+G V ++ PRF Sbjct: 103 ELQAELFGMHLKNPVGIAAGFDK-DAEAIDGLFDLGFGYVEVGSVTPEPQPGNPKPRFFR 161 Query: 64 LVKEDT--GFIGFKNME--------------------QIAEHPLEENLAALRRLKEDYPD 101 L ++D GF ++ + PL NL L Sbjct: 162 LEEDDACINRYGFNSLGHGHALARLRLRLAKFAQDHPSLFPSPLPANLVPPAGLPRSLRA 221 Query: 102 KVLIASIMGEN----EQQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPEL 155 L+A +G+N ++ R V+ G AD++ N S P Q L Sbjct: 222 GQLLAVNLGKNKASDPDSNDDYVRGVRTLGPFADVVVINVSSPNTPGLRALQGKQQLERL 281 Query: 156 VEKYCRA---VKRGSTLP-MLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNI 209 + + +G+ LP + K+ ++ + + +VA A + G +G+ NT + Sbjct: 282 LNDVVEERNKIAQGTGLPKIAVKVASDLSEDELADVASAVRSSGVEGVIVSNTTIRRKEL 341 Query: 210 DLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAA 269 +L + + I G SGK + P AL ++ +R PI G GGI + DA Sbjct: 342 NL-------VSGNQDQIGGLSGKPLFPYALNALKTLRPLLP-PSIPIIGCGGISSGSDAL 393 Query: 270 EFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 GA+ +QV T G + ++ +L Sbjct: 394 TMANAGASIVQVYTSFGFRGVGTPRLIKDEITEHLK 429 >UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=B7RZ94_9GAMM Length = 552 Score = 207 bits (526), Expect = 8e-52, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 136/307 (44%), Gaps = 19/307 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG--WGGVVFKTIGFFIANEVSPR 60 + +LS G PF + S V + +D G V K+IG + Sbjct: 11 SSNLSTELFGKTLSGPFTIPSGIVTTAVPIIQYIFDHMPEVGVVTTKSIGPEPRDG---- 66 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + V F N + + + + +L+ D+ L+ SI G + ++ E+A Sbjct: 67 YREPVLSQYAPGCFVNAVGLTNPGPQRSAELMAQLRVPE-DRFLLTSIFGGSIDEFVEVA 125 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 +++ +D +E N SCP + M +GQ P++V + AVK +P++ K+TPN Sbjct: 126 KILAPV-SDGLELNLSCPHAKGYGM--AMGQDPDMVREIVAAVKAVVDIPVIPKLTPNTP 182 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ +A AA+ GGADG AINTV G P+++ + G SGK + PI L+ Sbjct: 183 DITVIARAAEAGGADGFCAINTVGPG----YTSAHGHPVLS--NGAGGMSGKGILPIGLK 236 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 ++++ E+ D PI G GG+ + +D F GA + V + + + L Sbjct: 237 CVKEVA---EVSDLPIIGCGGVSSADDVRAFFDAGAEIVGVGSALTGMTTDEIGAYFKTL 293 Query: 301 SHYLADQ 307 + + Sbjct: 294 AADMDRD 300 >UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Clostridium botulinum RepID=C3KS38_CLOB6 Length = 298 Score = 206 bits (525), Expect = 1e-51, Method: Composition-based stats. Identities = 81/316 (25%), Positives = 142/316 (44%), Gaps = 28/316 (8%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L G+K NP ++SS + + + K D G G V+ KTI N S R Sbjct: 10 LQTEVLGMKLKNPVIIASSNLTDNEKSIRKFLDLGVGAVITKTIYIGEKNIQSGRILR-- 67 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 KE F N ++ + E L +L ++ + +I SI+ + + + LA ++E Sbjct: 68 KESQIF----NSTTYSKKSISEWTEILSKLYKE--NLPVIPSIVADTKDELVNLALQMEE 121 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 G +E SCP ++G + E + + RAV R ++P+ K+T + +V Sbjct: 122 VGCKALELGISCPN--------EIGIN-EKIYDFTRAVCREVSVPVSVKLTSEV----KV 168 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 ++ G +++ SI I +N +P+ GYSG A+KPI + I + Sbjct: 169 EEKVRKAMCAGAKSVSISDSIPAIVVNTDGTLPL----GVRCGYSGPAIKPIVQKNIYYL 224 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 + + D + GIGGIE D E+L +G++ +++ + I G VE + L + Sbjct: 225 KKNNA--DVEVIGIGGIENANDVLEYLYVGSSAVELCSCIFINGINQVERIIHDLKNMFL 282 Query: 306 DQGFDSLQEMVGLANN 321 D G ++ E++ A Sbjct: 283 DMGI-TVPEIINKALK 297 >UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria RepID=PYRD_DEIRA Length = 369 Score = 206 bits (523), Expect = 2e-51, Method: Composition-based stats. Identities = 69/317 (21%), Positives = 113/317 (35%), Gaps = 29/317 (9%) Query: 14 KFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDT--G 70 F +P L++ N + G+G V T+ PR L +++ Sbjct: 67 TFESPLGLAAGLDKN-AQAVPAFTAFGFGFVEVGTVTPLAQSGNERPRLFRLPEDEALIN 125 Query: 71 FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI-MGENEQQWEELARLVQEAG-- 127 +GF N A H L P V I + NE E+ + V+ G Sbjct: 126 RMGFNNGGTAAMHARLAVLTD-----RAAPVWVNIGKNKVTPNEDAAEDYRKCVRALGDL 180 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----KRGSTLPMLAKMTPNI--G 180 AD N S P LV V + P+L K+ P++ Sbjct: 181 ADAFVVNVSSPNTPGLRALQAADDLAALVRAVLDEVEAGRVRTLRRPPVLVKLAPDLHPA 240 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D A GA G+ NT S + + G SG+ + + Sbjct: 241 DFEASVGAVLDAGASGLIISNTTLSRGGLS---------HPNREQAGGLSGRPLTDRSTE 291 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 ++ + PI G+GG+ + EDA LL GA ++V + ++ G +V ++ +GL Sbjct: 292 LVRDAYRLTRGQ-VPIVGVGGVFSAEDAYAKLLAGADLVEVYSALIYRGPGLVREINAGL 350 Query: 301 SHYLADQGFDSLQEMVG 317 L G ++ ++VG Sbjct: 351 VKLLERDGVRNIADVVG 367 >UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus cereus RepID=C2QE06_BACCE Length = 350 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 65/332 (19%), Positives = 118/332 (35%), Gaps = 33/332 (9%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 L +KFPNP L++ ++ G+G V +I PR Sbjct: 37 RLECKLLDIKFPNPIGLAAGFDKF-ADVYPGLASLGFGSVEVGSITPKPQSGNPKPRLYR 95 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW-----EE 118 L + DT I ++N L R + + +G+N+ + Sbjct: 96 LPE-DTALINRMGFNSEGLDRAKQNFMTLPR------PNIPLGINLGKNKDTPNSDATLD 148 Query: 119 LARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----KRGSTLPM 171 + ++ + D N S P V L+ K P+ Sbjct: 149 YQKGLETLYSYGDYFVINISSPNTEGLRDLQYVDTLKPLLASILDKRNELCKKHNQYRPI 208 Query: 172 LAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 + K+ P++ + V + D + A NT S TN++ + G Sbjct: 209 ILKIAPDLTPEQLEGVISIIQEVKIDAVIAANTTISRTNLN---------SKFQKQNGGL 259 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + + I ++ + + PI G GG+ T EDA E + GA+ +Q+ T ++ G Sbjct: 260 SGKPLNHRSTEIISKIYRQTQ-GNLPIIGSGGVFTGEDAYEKIKSGASLIQIYTSMIYRG 318 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 + + + + L G ++ E +GL + Sbjct: 319 PSVAKHINQEILTLLEKDGLTNITEAIGLYHK 350 >UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whipplei RepID=Q83GM4_TROWT Length = 335 Score = 205 bits (521), Expect = 3e-51, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 115/311 (36%), Gaps = 31/311 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L T G+ F P +++ ++ Y G+G V T+ PR Sbjct: 41 LGTTSMGLYFDTPLGIAAGFDKF-ADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHR- 98 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEEL 119 V I + EN+ +R+ P +I +G+++ + ++ Sbjct: 99 VMSQKALINSMGFNNPGAQKMRENILKVRKSGRRLP---IIGVNIGKSKVCPLEESAKDY 155 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK---RGSTLPMLAK 174 + + +D + N S P VG + K R+VK P+L K Sbjct: 156 VKSFELLADVSDYLVINVSSPNTEGLRTLQSVGN----LNKILRSVKPIADRFKRPVLIK 211 Query: 175 MTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 ++P++ D+ +AL K G G+ A NT ++ G+P S G SG Sbjct: 212 ISPDLSNSDVTNIALLVKEFGLAGVVASNTT--------TKRTGLPN-EFSSLHGGLSGP 262 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 +K +L ++ +R F I +GG+ + D E L GA +Q T + G Sbjct: 263 MLKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNGPYW 322 Query: 293 VEDMASGLSHY 303 ++ LS Sbjct: 323 ASNINRDLSRL 333 >UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebacterineae RepID=PYRD_MYCTA Length = 357 Score = 205 bits (521), Expect = 3e-51, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 130/329 (39%), Gaps = 29/329 (8%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ T GV+FP P L++ + + + G+G T+ +PR L Sbjct: 49 LASTVFGVRFPAPLGLAAGFDKDGTALSSWGA-MGFGYAEIGTVTAHPQPGNPAPRLFRL 107 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI----MGENEQQWEE 118 + +GF N H L R + + P V I G+ + Sbjct: 108 ADDRALLNRMGFNN------HGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRA 161 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 AR+V A + N S P V E + AV+ ++ P+L K+ P+ Sbjct: 162 SARMVGPL-ASYLVVNVSSPNTPGLRDLQAV----ESLRPILSAVRAETSTPVLVKIAPD 216 Query: 179 IGDMCE--VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 + D +A A GI A NT S + P V+ + G SG + Sbjct: 217 LSDSDLDDIADLAVELDLAGIVATNTTVSRDGLT------TPGVD-RLGPGGISGPPLAQ 269 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 A++ ++++ R + +GGIET +DA E + GA+ LQ TG + G R +D+ Sbjct: 270 RAVQVLRRLYDRVGDR-LALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWAKDI 328 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVP 325 G++ L D GF SL E VG A Sbjct: 329 HEGIARRLHDGGFGSLHEAVGSARRRQPS 357 >UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R4R9_9RHOB Length = 367 Score = 205 bits (521), Expect = 3e-51, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 123/329 (37%), Gaps = 29/329 (8%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + F NP +++ N E G+G V T+ PR L Sbjct: 47 LEYKLGDLTFKNPVGMAAGFDKN-AEAITPLMKLGFGHVEVGTVTPLPQEGNPKPRNFRL 105 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 D I + R+++ ++ +G N+ + +A V Sbjct: 106 -SADRAVINRYGFNNDGHDVV------YERIRKAGRTPGVLGINVGANKLSEDRVADYVL 158 Query: 125 EAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-----GSTLPMLAK 174 AD + N S P + L+ A G +P++ K Sbjct: 159 GVKRFAELADYLTANISSPNTPGLRDLQEKDALAHLLSAIVNARDEQEDRLGRKVPVMLK 218 Query: 175 MTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ + + E+A DG+ NT + + +Q+ G SG Sbjct: 219 IAPDVTEEALKEIAEVVMTNKVDGMIVSNTTIARPSTLKDQQQAE-------EAGGLSGA 271 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + A + + R D P+ G+GG++T E AA + GA +Q+ +G++ G + Sbjct: 272 PLFERATIALAKTRRAVG-PDLPLFGVGGVDTPEKAAAKIFAGANQIQLYSGMVYEGQTL 330 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGLANN 321 V+ + LS +A +G +LQE+VG+ N+ Sbjct: 331 VKKINKHLSRLVAARGVSNLQELVGIDND 359 >UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter pasteurianus RepID=C7JI08_ACEP3 Length = 336 Score = 204 bits (520), Expect = 3e-51, Method: Composition-based stats. Identities = 74/341 (21%), Positives = 128/341 (37%), Gaps = 22/341 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + D+ + G++ +P S+SP+ E + D G +V ++ Sbjct: 1 MAMDMRTNYLGLELAHPVVASASPLTADLEGILRVADAGASAIVMASVFEEDIQAQELAE 60 Query: 62 DHLVKEDTG----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 L + G+ + A PL+ LA LR E +IAS+ G W Sbjct: 61 AALWETGENSHPEAAGYFPVMHHAS-PLDGRLAVLRSAAERA-GVPIIASLNGCTPAGWL 118 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 A+ +++AGA IE NF G+ V E + R V+ +P+ K++P Sbjct: 119 RFAKDMEQAGAAAIELNFWHVPTNPDETGAQVE---ERCIQVLRDVRAQVKVPVSVKLSP 175 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + GA GI N+ L + + V S + Sbjct: 176 FFSSPGNMVKRLSENGAGGIVLFNSFYEPGLRSLTESAEVDFVP--------SSAYELRL 227 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 L + + H + D IS GG+ + D A+ LL GA V + ++Q G + + Sbjct: 228 PLMWAALLSEHCQA-DLAIS--GGVHSGMDVAKCLLAGADVAMVASVLLQKGPNYISTLL 284 Query: 298 SGLSHYLADQGFDSLQEMVG--LANNNIVPAEDLDRSYIVY 336 + L +++ Q +++E G A AED R+ + Sbjct: 285 NELREWMSMQNLGAVKEFKGRMAARGTAAQAEDFLRTQYRH 325 >UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromonas sp. RCC299 RepID=C1EIH8_9CHLO Length = 488 Score = 204 bits (520), Expect = 4e-51, Method: Composition-based stats. Identities = 73/366 (19%), Positives = 127/366 (34%), Gaps = 55/366 (15%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 L++ G++F NP L++ + A G+G V ++ PR Sbjct: 129 PPALAVDAWGLRFANPIGLAAGFDKDAKAFPA-LGAMGFGFVEIGSVTPKPQPGNPKPRV 187 Query: 62 DHLVKEDT--GFIGFKNMEQ-IAEHPLEENLAALRRLKEDYPDKVL-------------- 104 L + GF + A LE A R + ++ + Sbjct: 188 FRLRELGAVINRYGFNSEGHEPARARLEAYRADTRATQSEFDATPVTPVTPEGAGVPRRL 247 Query: 105 ------IASIMGENE-----QQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQ 151 + +G+N+ ++ A V+ G AD I N S P Sbjct: 248 AERGAPVGVNLGKNKLTPEAAAADDYALGVRALGHTADYIVVNISSPNTPGLRALQGKAH 307 Query: 152 SPELVEKYCRAVKRGS-------------TLPMLAKMTPNIGD--MCEVALAAKRGGADG 196 L+ K A + P+L K+ P++ D + +V AA DG Sbjct: 308 LKGLLRKVLAARDESALKSRTGGGQTHAHKPPVLLKIAPDLTDGDIKDVVAAATSCAVDG 367 Query: 197 IAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPI 256 I NT + G G SGK + + + ++ + P+ Sbjct: 368 IIVSNTTIARPEDVAAHARG-------GEAGGLSGKPLMDPSTEVLFRVYQLTGGK-IPL 419 Query: 257 SGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMV 316 G GG+ + DA E + GA+ +Q+ T G +V M + L+ L + G++S+ E + Sbjct: 420 VGCGGVASGRDAYEKIRAGASLVQMYTAFAYAGPALVPAMKAELAACLREDGYESVAEAI 479 Query: 317 GLANNN 322 G A+ Sbjct: 480 GAAHRK 485 >UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobacteraceae RepID=D1B1W1_SULD5 Length = 355 Score = 204 bits (518), Expect = 6e-51, Method: Composition-based stats. Identities = 69/331 (20%), Positives = 127/331 (38%), Gaps = 40/331 (12%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 K L T F NP L++ N M G+G + + T+ PR Sbjct: 52 KRLEQTLFDRTFHNPIGLAAGFDKN-ATMIKMLTALGFGHIEYGTMTPEPQSGNAKPRCF 110 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 +E++ +GF N E +RL+ YP +A+ +G+N+ Sbjct: 111 RFPEEESIQNAMGFNN---------EGMHKIAKRLESLYPFATPLAANIGKNKITSAENA 161 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 + +E+L + ++ +D + N S P Q+ +++ K + P+L Sbjct: 162 LKDYEKLIKRFKDV-SDFLVVNISSPNTPGLRDL----QNEAFIKELFMMAKELTCKPVL 216 Query: 173 AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ + E+ A GA GI A NT I ++ G S Sbjct: 217 LKIAPDLEIKEAIELCSCALENGAKGIVATNTT-----------IDYSLLPNAKDFGGIS 265 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 GK + + R + + + +GGI++ E+A L GA+ LQ+ + + G Sbjct: 266 GKVLCEKSFRMFEGIAKEF-FGKTTLISVGGIDSAEEAYRRLKAGASLLQIYSAFIFKGP 324 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 + + G+ + GF + E++G Sbjct: 325 SLNRTINLGILERMERDGFHHISEVIGCDRR 355 >UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma gondii RepID=B6KTR1_TOXGO Length = 592 Score = 203 bits (516), Expect = 1e-50, Method: Composition-based stats. Identities = 64/367 (17%), Positives = 133/367 (36%), Gaps = 57/367 (15%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++ G+KF +P L++ + E A G+ + +I PR L Sbjct: 231 LNVDINGLKFLSPIGLAAGFDKH-AEAPAALLRMGFSFLEVGSITPKPQPGNPKPRLFRL 289 Query: 65 VKEDT--GFIGFK-NMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEE 118 ++ + GF N A+ LE A RL++ + + ++ +G+N+ + Sbjct: 290 YEDRSVINRFGFNSNGADYAQTQLEAFSEA--RLRDPFTAQGVLGVSLGKNKTSEDAVAD 347 Query: 119 LARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK------------ 164 L V++ G AD + N S P +++ + Sbjct: 348 LREGVKKLGRFADFLVVNLSSPNTPGLRSLQSASHLAAIIDGVQEELDALDRQAQAASQK 407 Query: 165 ---------------------RGSTLPML-AKMTPNIG--DMCEVALAAKRGGADGIAAI 200 + P+ K+ P++ + +A A DG Sbjct: 408 QRNERRRHGGNPEETKAFYANQTGRRPLFFVKIAPDLSMEEKESIAKVALEKNLDGFVVS 467 Query: 201 NTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIG 260 NT + KS G SG+A+K ++ + M + + I G Sbjct: 468 NTTIQRPETLKSP--------AKSETGGLSGRALKHLSTACVSDMYKLTQGK-LAIIATG 518 Query: 261 GIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 G+E+ DA + + GA+ +++ + ++ G ++ + + L H L ++G+ + VG + Sbjct: 519 GVESGRDALDKIEAGASLVELYSSMVYIGPQVARRVKNELYHALNEKGYKDVAAAVGRKH 578 Query: 321 NNIVPAE 327 ++ + Sbjct: 579 KHVPEKK 585 >UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L830_PLAKH Length = 556 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 70/346 (20%), Positives = 125/346 (36%), Gaps = 44/346 (12%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVK 66 G+ F NPF +++ N G+ + TI PR V+ Sbjct: 222 TGIGGLNFINPFGVAAGFDKNGV-CIDGILKLGFSFIEVGTITPKPQKGNDKPRIFRDVE 280 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKED--YPDKVLIASIMGENEQQ---WEELAR 121 I I + ENL R ++ + + +G+N+ E+L+ Sbjct: 281 T-RSIINCCGFNNIGCDEVTENLKRFREKQKTDKLLHRHFVGVSLGKNKDSADILEDLSY 339 Query: 122 LVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-------------- 165 + G AD I N S P + ++ + V + Sbjct: 340 CISRIGKYADYIAINVSSPNTPGLRDNQQSERLQRIILRVKEEVDKLEESNVVGDDVVRG 399 Query: 166 ------GSTLP-MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIG 216 P + K+ P++ G+ ++A + DG+ NT NI Sbjct: 400 DTWVNTSKRKPLVFVKLAPDLEEGEKKKIADVLLKTKVDGMIICNTTTEKFNIK------ 453 Query: 217 MPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGA 276 N + G SG+ +K ++ +FI QM + + PI GGI T +DA E + GA Sbjct: 454 ----NFQDKKGGVSGEKLKDVSTKFISQMYNYTN-KKIPIIASGGIFTGKDALEKIEAGA 508 Query: 277 ATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 + Q+ + ++ G + + L H L +G+ L++ +G A+ Sbjct: 509 SVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKLEDAIGKAHRR 554 >UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_LACBS Length = 499 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 71/348 (20%), Positives = 130/348 (37%), Gaps = 40/348 (11%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L+ G + NP L++ + E ++ G+ V ++ PR H Sbjct: 108 RLNCQIWGQEASNPVGLAAGFDKDG-EAIDGLFELGFSWVEIGSVTPKPQPGNPRPRVFH 166 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRL---------KEDYPDKVLIASIMGENE- 113 L ++ + N L+ +R + + L+A +G+N+ Sbjct: 167 LPEDSS----LINRYGFPSQGHASVLSRIRSRIPPFTSGPNRASLREGCLLAVNLGKNKE 222 Query: 114 ---QQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST 168 ++ V+ G +D++ N S P + L++ +A S Sbjct: 223 SPADSIDDFVTGVRTFGPYSDVLVVNVSSPNTPGLRGLQNRDVLERLLDGVTKARDELSP 282 Query: 169 ------LP-MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 P ++ K P++ ++ ++A + DG+ NT +N Sbjct: 283 SVLTFRKPKLVLKFAPDLNESELADIADVIRNSSIDGVIVSNTTVQRPKSLVNP------ 336 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 KS + G SG VKP++L+ ++ +R H P+ G GGI T DA EF GA+ + Sbjct: 337 --NKSEMGGLSGPPVKPLSLKALRILRGHLPA-SIPLIGCGGISTGADALEFAKAGASMV 393 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 QV TG G + + L +G + E+V A + + E Sbjct: 394 QVYTGFGYDGVGACRRIKDQVVDELTREG-KTWSEVVNEAVDKLSLKE 440 >UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flavoviridis RepID=B9UIZ1_9ACTO Length = 326 Score = 202 bits (513), Expect = 3e-50, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 119/298 (39%), Gaps = 21/298 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L + G+ NP + S + + + G G VV KTI + R L Sbjct: 31 LEVPILGLSPANPVIVGSGLLTDQERNIRRLLGKGAGAVVTKTIHPSPPQGLDERILRLP 90 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 +G N ++ + L LR +D +IAS+ + + LA+ V+ Sbjct: 91 ------VGMLNSTTYSKRSVNRWLKTLRSFADD--RLPVIASLHADTPGELAMLAKDVET 142 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 G +E SC +P+ V Y V+ + LPM K+ G + + Sbjct: 143 TGCRALELGISCLNEEDGLEDD----NPDRVYAYTSEVRSKTALPMSVKLAVGEG-LRDR 197 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 AA GGAD I +T+ ++ + + + GYSG +KP+ L I Q+ Sbjct: 198 VRAAIAGGADAITLSDTIAGAAVSPTTGRLEL------NGVFGYSGPGLKPLVLAAIWQL 251 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 R P+ G GG+ + D A++L +GA+ QV T + YR +E + + Sbjct: 252 RKSG--IALPVMGCGGVSSGRDVADYLSVGASVAQVYTALHTDMYRTLERILAETRDL 307 >UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/Pelodictyon group RepID=B3EIF4_CHLL2 Length = 375 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 64/331 (19%), Positives = 123/331 (37%), Gaps = 37/331 (11%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + DLS T+ G+K NP +SS + E G G VV K++ F Sbjct: 47 IMADLSTTWMGLKLRNPLIAASSGLTGTLEGVKAVASHGAGAVVLKSL-----------F 95 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRR------------LKEDYPDKVLIASIM 109 + + +TGF +N + E+ + R + D +IASI Sbjct: 96 EEQIMLETGFAEGQNAQHHYYAQAEDYIREYTRGNALNGYLDLITSCKLAVDIPVIASIN 155 Query: 110 GENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL 169 ++ +W A ++ AGAD +E N ++ ++ L + R + Sbjct: 156 CVSQGEWLSFASQIERAGADGLEINIF---LSPSDSSRSSTENERLYGDVLENITRVVRI 212 Query: 170 PMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 P+ AK++ + A++ G G+ N S + D+ ++ + Sbjct: 213 PVAAKISSYFSSLAAEAVSLSHSGIRGLVLFNRFFS-PDFDIETFDV-------TAGGVF 264 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 S +LR++ + + ++ G+ + LL GA +++ + + + G Sbjct: 265 SSPTDIYHSLRWVAILSGRVQ---CDLAASTGVHDGNGLIKQLLAGARAVEIASVLYKKG 321 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 + M L Y+ Q F S E +G + Sbjct: 322 LGEIGIMLGELEEYMERQRFSSTGEFIGRMS 352 >UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVY1_9BACT Length = 325 Score = 199 bits (506), Expect = 2e-49, Method: Composition-based stats. Identities = 75/341 (21%), Positives = 127/341 (37%), Gaps = 25/341 (7%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 + G+ P+P +SSSP + + + +G G VV K+I H D Sbjct: 4 KYLGLDLPSPIIVSSSPYTSNVKSVEQCAASGAGAVVLKSIFEEQI------LHHAAALD 57 Query: 69 T-GFIGFKNMEQIAEHPLEENLAA----LRRLKEDYPDKVLIASIMGE-NEQQWEELARL 122 T + + E + L E+ A L + + +IASI ++ W E A Sbjct: 58 TVSDSAYGDAEVYLQRYLGEDYKAGFLRLVQEARSKTELPVIASINCVVDKGDWIEYATA 117 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + +AGA +E N HA ++ + + V +P+ K+ + ++ Sbjct: 118 MADAGASALELNIFIQSTDIHAQARELELNY---AEIVGRVAGAVKIPVSVKLPMRLTNV 174 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 ++ A GA G+ N ++D+ + S YS LR + Sbjct: 175 FALSSALLGHGARGVVFFNRFFE-PDVDVERMT-------FVESSPYSEPTELRNVLRMV 226 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 D +S G+ E A + LL GA +QV T I Q G+ ++ +M + Sbjct: 227 AICSAVLPQLDLSVS--TGVHDGEAAVKALLCGAEAVQVCTAIHQKGFEVIAEMNEYIDR 284 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDK 343 + QGF SL E G N + R + + K Sbjct: 285 WSERQGFGSLDEFRGRLNFKNDTSAMFQRVQYMKYFPSEAK 325 >UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobacteria RepID=PYRD_COXB1 Length = 347 Score = 198 bits (504), Expect = 3e-49, Method: Composition-based stats. Identities = 64/311 (20%), Positives = 124/311 (39%), Gaps = 37/311 (11%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVK 66 G++FPNP L++ N E + G+G + + PR L + Sbjct: 47 TVVFGIEFPNPVGLAAGLDKNG-EYMDELLGLGFGFIEVGAVTPKPQPGNSKPRIFRLPQ 105 Query: 67 EDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 +GF N+ ++ + L+R K K ++ +G+N E A Sbjct: 106 ARALINRMGFNNL------GVDYLVEQLKRRK----VKGIVGVNIGKNLTTPLEKAHEDY 155 Query: 125 E-------AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-----GSTLPML 172 + + D + N S P +L+ + +R +P+ Sbjct: 156 QNCFEKLYSYVDYVTINISSPNTPELRQLQSERYLADLLTRLKEDQRRLEDQYHKRVPLF 215 Query: 173 AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ ++ +A A + +GI A NT S + G + + G S Sbjct: 216 LKIAPDLTPEEIQTIATLALQHRIEGIVATNTSCS--------RQGTEKLPNANEAGGLS 267 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 GK + P+ L+ ++Q+ + + PI +GGI + E+A + GA +Q+ TG++ G Sbjct: 268 GKPLFPMTLQVVKQLHSFLG-DEIPIVAVGGIFSGENAQTLINAGARLVQLYTGLIYEGP 326 Query: 291 RIVEDMASGLS 301 +V+++ L+ Sbjct: 327 ELVKNIVEFLT 337 >UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family protein n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31DA9 Length = 303 Score = 198 bits (503), Expect = 4e-49, Method: Composition-based stats. Identities = 73/313 (23%), Positives = 120/313 (38%), Gaps = 25/313 (7%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEM----CAKAYDTGWGGVVFKTIGFFI-AN 55 M L +FCG++ +P S A + V KT+ Sbjct: 1 MSAPSLPTSFCGIELAHPIVNGSGTFDAIAAQRAFGDALVEQFPFAAFVSKTVTVAPREG 60 Query: 56 EVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 PR L IG N L +L L RL LI ++MG ++ Sbjct: 61 NPPPRLWELPAGLINSIGLPNKGLAGY--LTHDLPELARLP-----VPLIVNVMGFTREE 113 Query: 116 WEELARLV-QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 +L + +E N SCP + + G+ +G P + V+ + P++ K Sbjct: 114 VAQLVTAFAERDEVAALELNVSCPNVET---GTIMGSDPTETARLVERVRPLTQKPIVVK 170 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 +TPN D VA AA+ GADG++ INT++ + L+ + P + G SG V Sbjct: 171 LTPNASDPGAVAEAAEAAGADGLSLINTIRGMA---LDPRTREPWLGA--GTGGVSGATV 225 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + +AL + + P+ +GG++ DA + L GA + V T + Sbjct: 226 RAVALAQVSDVAQRV---SIPLIAMGGVQRGRDADDLLRAGATLVAVGTESFR-DPAAGR 281 Query: 295 DMASGLSHYLADQ 307 +A L ++ Sbjct: 282 RVAHELERLRRER 294 >UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5YA20_COPPD Length = 274 Score = 197 bits (502), Expect = 5e-49, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 113/294 (38%), Gaps = 25/294 (8%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVK 66 ++ + NPF SS G +G V KTI P LV+ Sbjct: 4 AVRLKKLTLKNPFIASSGTCGYADADLIPLDK--FGAAVTKTITLLPRQGNRP--PRLVE 59 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 G + ++ + ++ L ++ LI S+ GE+ + + + + Sbjct: 60 TPAGLVNSIGLQNMGLEAFKQFLTDFKK------PTTLIVSVGGESPEDFATIVEELNTY 113 Query: 127 G-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 D E N SCP + + G VG+ V A + +T P+L K++P + + Sbjct: 114 DLIDAFELNLSCPNVKTG--GEVVGKDYVTVSNILEASLKSTTKPLLVKLSP-FTEQLDK 170 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 L + NT ++ D++ + G P++ S G SG A+ PI L I + Sbjct: 171 ILQHWESKVEAFVLFNTFPAM---DIDPRSGKPVLGAVS--GGLSGPAIYPIVLNSIYKY 225 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + GGI T + A +F++ GA L++ TG + +E + Sbjct: 226 SKA-----HTLVASGGIATTDIAKKFIMAGARALEIGTGNLWN-PAFIEMLLKE 273 >UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonproteobacteria RepID=PYRD_NAUPA Length = 359 Score = 197 bits (502), Expect = 5e-49, Method: Composition-based stats. Identities = 72/336 (21%), Positives = 128/336 (38%), Gaps = 42/336 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L ++F NP +++ + M G+G + PR Sbjct: 51 LHQKIWDLEFKNPVGVAAGFDKH-ATMVYGWPALGFGWGEIGAVTPKPQPGNEKPRAWRH 109 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 ++ + GF N +RLK+ YP + I + +G+N+ EE R Sbjct: 110 IEYEAVQNAYGFNNEGVEVIK---------KRLKKIYPFILPIGANIGKNKTTPEE--RA 158 Query: 123 VQEAGADMIEC---------NFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 V++ + E N S P + E + +K + P+L Sbjct: 159 VEDYKILVNELKDVVDFFVVNVSSPNTPGLRDLL----NAEFISSLFGELKNLTDKPILI 214 Query: 174 KMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K +P++ D + +A + GADGI NT + +VN + G SG Sbjct: 215 KFSPDMEDELIINLANYSVLAGADGIIVTNTT-----------VNYDLVNSEIKRGGISG 263 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 K + + ++ + PI +GGI++ E+A + + GA+ LQV T I+ G Sbjct: 264 KPLAQRSYEVLRIVAGEV-FGKVPIISVGGIDSAEEAYKRIKAGASLLQVYTAIIYKGPG 322 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 IV ++ GL L G+ + E +G+ + + Sbjct: 323 IVGEINRGLIELLKKDGYSHISEAIGVEIPKKLENK 358 >UniRef50_B3EQ67 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B3EQ67_CHLPB Length = 328 Score = 197 bits (501), Expect = 5e-49, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 128/331 (38%), Gaps = 39/331 (11%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS T+ G+K NP SS + E KA D G G VV K++ F+ Sbjct: 1 MADLSTTYMGLKLKNPVIAGSSGMTESVESVTKAADAGAGAVVLKSL-----------FE 49 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLK------------EDYPDKVLIASIMG 110 + ++G+ N + EE + R +D D +IASI Sbjct: 50 EQIHNESGYAIDSNEQDYYYAQAEEYIRNYTRGNDLRAYLDLISGCKDAVDIPVIASINC 109 Query: 111 ENEQQWEELARLVQEAGADMIECN-FSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL 169 + +W + A Q AGAD +E N F P D GQS ++ V ++ Sbjct: 110 VSSSEWTDFAVQAQRAGADGLELNMFMLPSDPDR----DSGQSEQVYLDVLEKVTGLISI 165 Query: 170 PMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 P+ AK++ + + G G+ N S +ID+ S + + Sbjct: 166 PVAAKISYYFSGLANIVEKIASTGISGLVMFNRFFS-PDIDIENFEVK-------STNVF 217 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 S ++LR++ + + I+ GI + + LL GA Q+ + + G Sbjct: 218 SSPQDLSLSLRWVAMLSSRVP---CDIAASTGIHDGKALIKQLLAGAKAGQIASVLYSEG 274 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 Y ++ M L Y+ F +L EM+G + Sbjct: 275 YEVISPMLEELDAYMERHNFSTLDEMIGKMS 305 >UniRef50_B3DVT8 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DVT8_METI4 Length = 314 Score = 196 bits (498), Expect = 2e-48, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 124/337 (36%), Gaps = 41/337 (12%) Query: 21 LSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI 80 + +SP+ E + G VV ++ F V D Sbjct: 1 MGASPLSGSLEGIQELEKAGAAAVVLPSL--FEEQIVKEAIAENPYLDF-------SGNY 51 Query: 81 AEHPL--------EENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIE 132 +E P+ E L +R K +IAS+ G + W A+ ++EAGAD IE Sbjct: 52 SEFPMSSEYLLTSESYLDFIREAKRKA-RIPIIASLNGRSPGWWCRYAKQIEEAGADGIE 110 Query: 133 CNFSCPQMTSHAMGSDVGQSPELVE----KYCRAVKRGSTLPMLAKMTPNIGDMCEVALA 188 N D+ Q + +E + R V++ +P+ K+ P ++ +A Sbjct: 111 LNIY-------PFPLDINQPSDSIEMDTLEIVRLVRKEIQIPLGVKIYPYYTNVGNMAQR 163 Query: 189 AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH 248 + G +G+A N +ID+ + +S +AL +I + Sbjct: 164 FQAAGVNGLALFNRFLQ-PDIDVENFEIKRGIQLGTSR-------DNRLALSWIAFLYNR 215 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 +L ++ GG+ DA +L GA+ + V + I++ G + M + ++ Sbjct: 216 LKLD---LAATGGVMEAVDAIRLILAGASVVMVCSAILEKGIGYIPVMEKEIVEWMERHR 272 Query: 309 FDSLQEMVG-LANNNIVPAEDLDRSYIVYPRINLDKC 344 F SL++ G L+ R V + D+ Sbjct: 273 FSSLEDWRGSLSQQGGASPSRFFRLQYVELLADADRR 309 >UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10 Tax=Saccharomycetales RepID=PYRD2_KLUMA Length = 446 Score = 196 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 58/343 (16%), Positives = 121/343 (35%), Gaps = 38/343 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + G NP ++ + E + G+G V ++ PRF L Sbjct: 107 LHVNVFGKTLTNPVGCAAGLDKDG-EAIDGIFAGGFGYVEIGSVTPLPQPGNPKPRFFRL 165 Query: 65 VKEDT--GFIGFK---------NMEQIAEHPLEENLAALRRLKEDYP--DKVLIASIMGE 111 ++ GF N++ + ++ L+ +G+ Sbjct: 166 PMDEAVINRYGFNSSGHDSVVKNLQNRVSRFINSYFCNDINAVDNLSLYQNKLLGINLGK 225 Query: 112 NE--QQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS 167 N+ + ++ + V++ AD++ N S P L+ + Sbjct: 226 NKNGDEVQDYLKGVEKFQKYADVLVINVSSPNTPGLRGLQKESILTNLLSQVVAKRDSLV 285 Query: 168 T-----------LPMLAKMTPNIGDMCEVALAAKR--GGADGIAAINTVKSITNIDLNQK 214 + P+L K+ P++ + A+A DGI NT + + Sbjct: 286 SSGNVLGAKTHRPPVLVKVAPDLEEEEIKAIAEAAKKSKVDGIIVSNTTIQRPASLITED 345 Query: 215 IGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLL 274 + + G SGK +KP++L+ ++ M + + + G GGI + DA EF Sbjct: 346 KNLV-----AQAGGLSGKPLKPLSLKALKTMAHYTKGSGLVLVGCGGISSGADAIEFAKA 400 Query: 275 GAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVG 317 GA +++ T G ++ + ++ L + + +++G Sbjct: 401 GATMVELYTCYAYRGPGLIARVKDEITEQLKREN-KTWSQIIG 442 >UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q0J918_ORYSJ Length = 601 Score = 196 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 111/324 (34%), Gaps = 39/324 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + G KF NP L++ N E G+G V ++ PR L Sbjct: 217 LGLEIWGRKFTNPIGLAAGFDKN-AEAVEGLLGMGFGFVEVGSVTPLPQEGNPKPRIFRL 275 Query: 65 VKEDT--GFIGFKNME----------QIAEHPLEENLAALRRLKEDYP-----DKVLIAS 107 + GF + Q + +EE ++ D ++ Sbjct: 276 REHGAVINRCGFNSEGIVVVAKRLGAQHGKRKMEETSSSTSPTTSDVKQGGKAGPGILGV 335 Query: 108 IMGENEQQWEELARLVQEA-----GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 +G+N+ + A VQ AD + N S P Q +LV+K A Sbjct: 336 NLGKNKISEDATADYVQGVHTLSQYADYLVINVSSPNTPGLRKLQGRKQLKDLVKKVQAA 395 Query: 163 VKR-----GSTLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 P+L K+ P++ D+ ++A A DG+ NT S Sbjct: 396 RDEMQWAEDGPPPLLVKIAPDLSKQDLEDIAAVALALRLDGLIISNTTISRP-------S 448 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 G SGK + ++ +++M + P+ G GG+ + EDA + + G Sbjct: 449 PADTHPLAQEAGGLSGKPLFDLSTNVLREMYILTRGK-IPLIGCGGVSSGEDAYKKIRSG 507 Query: 276 AATLQVTTGIMQYGYRIVEDMASG 299 A +Q+ T G ++ + Sbjct: 508 ATLVQLYTAFAYGGPALIPRIKKA 531 >UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=candidate division TM7 RepID=UPI00016B255A Length = 394 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 79/332 (23%), Positives = 133/332 (40%), Gaps = 27/332 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L CG+ F NP LS+ N E+ G+G + +I A P F Sbjct: 72 RLKQNICGINFSNPVGLSAGFDKN-IELIPTMSMVGFGYMTGGSITITPRAGNPRPWFYR 130 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAAL--RRLKEDYPDKVLIASIMGENEQQWEELAR 121 L K + + + + + +N+ + P + IA + + ++ + Sbjct: 131 LPKSKSIVVHA-GLANDGANIILQNIKRQYKKEANRKIPLFISIAVVARSQDSTEADIIK 189 Query: 122 LVQEA--------GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 V EA A +E N SCP + + + + L+ + K + +P+ Sbjct: 190 DVCEAMSLVSGSGLAKAVEINISCPNIDDNQPFTYPDKLDNLLSQLD---KINADMPIFI 246 Query: 174 KMTPNIGDMCEVALAAK---RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 KM PN+ D L + + +G+ N VK +NI+L K+ + G S Sbjct: 247 KM-PNLVDFVRFGLILEIISKHKINGVTISNLVKDRSNINLKDKLPESV------KGGLS 299 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 GK + +L I+ R I G+GGI EDA + G++ + + TG+M G Sbjct: 300 GKPCRDRSLDLIKFTYEKYGDR-LLIIGVGGIFNAEDAYLKIRAGSSLVALITGLMFEGP 358 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 ++V D+ GL L GF SL E +G+ Sbjct: 359 QMVGDINHGLDKLLKRDGFSSLTEAIGIDVKK 390 >UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria RepID=PYRD_FLAPJ Length = 350 Score = 194 bits (494), Expect = 4e-48, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 121/321 (37%), Gaps = 47/321 (14%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFD 62 K L G+KF NP L++ ++ + + G+G + T+ R Sbjct: 48 KRLEREVFGLKFKNPVGLAAGFDK-DAKLYKELSNFGFGFIEIGTLTPKGQEGNPKKRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 L ++ +GF N L A+ RLK++ + VLI +G+N+ Sbjct: 107 RLQEDSAIINRMGFNNGGV---------LEAVERLKKN--NGVLIGGNIGKNKLTPNENA 155 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---------- 162 +E + + D N S P + + +L+ Sbjct: 156 TSDYEICFDALYDY-VDYFVVNVSSPNTPNLRELQEKEPLTQLLNTLQNKNQNKQKQTRD 214 Query: 163 -VKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 + P+L K+ P++ + + ++ K GI A NT S + +I Sbjct: 215 GAQSSGAKPILLKIAPDLTNEQLLDIIDIVKTTKIAGIIATNTTISREGLQSINRI---- 270 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 + G SGK + + I+ + + FPI G+GGI +DA E L GA+ + Sbjct: 271 -----EMGGLSGKPLTNRSTEVIRFLSQKSN-KAFPIIGVGGIHCVQDAIEKLEAGASLI 324 Query: 280 QVTTGIMQYGYRIVEDMASGL 300 Q+ TG + G +V+ + + Sbjct: 325 QLYTGFIYEGPALVKAINKEI 345 >UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding protein n=5 Tax=unclassified Gammaproteobacteria RepID=A0Z3E6_9GAMM Length = 551 Score = 194 bits (492), Expect = 6e-48, Method: Composition-based stats. Identities = 82/312 (26%), Positives = 144/312 (46%), Gaps = 23/312 (7%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG--WGGVVFKTIGFFIANEVSPRFDHLVK 66 +F G F + S V + + G + K+IG PR + Sbjct: 4 SFLGKTLSGGFTVPSGIVTTAPSIIQRVIRDMPEIGVITTKSIGLE------PRLGYREP 57 Query: 67 EDTGFIG--FKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + F F N + +LA+L +L+ D+ L+ SI G + +++ +A++++ Sbjct: 58 VYSQFAPGCFVNAVGLTNPGAHASLASLGQLRVPE-DRFLLVSIFGGSVEEFVAVAKILE 116 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 AD E N SCP + + M +GQ P++V + AVK+ + P++ K+TPN+ ++ E Sbjct: 117 PV-ADGFELNLSCPHASGYGM--AMGQDPKIVHEIIAAVKQVVSKPVIPKLTPNVTNIAE 173 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 + AA GADG+ AINTV + G +++ + + G SGK V P AL+ I++ Sbjct: 174 IGQAALDAGADGLCAINTVGPG----YTESHGEAVLS--NGVGGMSGKGVLPTALKCIRE 227 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 +R + D PI G GG+ + D GA + + + + ++ S LS L Sbjct: 228 LRA---ITDKPIIGCGGLSSAADVNAAKHAGATIVGIGSALSGMDTEDLQRYFSTLSKDL 284 Query: 305 ADQGFDSLQEMV 316 QG + ++ Sbjct: 285 DRQGNQAETQIR 296 >UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBI0_BLASB Length = 320 Score = 194 bits (492), Expect = 6e-48, Method: Composition-based stats. Identities = 63/319 (19%), Positives = 130/319 (40%), Gaps = 20/319 (6%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLV 65 S G++ + +S + + + D+ G +V K+ + PR+ Sbjct: 16 SARINGIQLSSCIMNASGALCTTGQELSDLLDSSSGAIVTKSCTRQPRKGNIKPRYFEWN 75 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ- 124 +G N+ ++ L L K P + SI G + ++ L + Sbjct: 76 VGSINSMGLPNL------GIDFYLNFLEEKKTKKP---VFLSISGLSIEEIFFLLKKANF 126 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--M 182 + IE N SCP + +G D+ + + +E + + P+ K+ P + + Sbjct: 127 SSKITAIELNLSCPNLQEEILGYDLYKIYDFLENVFKF----NEKPLGIKLPPYFKEEYI 182 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 ++L + + IN++ + I ++ + ++ ++ G G +KP AL I Sbjct: 183 KNMSLILNQFPIVFVTCINSLPN--GIFVDPRNETSVIQPRNGFGGIGGSIIKPFALANI 240 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 ++ T+ +D I G GGI +D E +L GA+ +Q+ T +M+ G + E + + Sbjct: 241 RKFYTYLR-KDISIIGCGGISYGKDIFEHILCGASAVQIGTQLMKEGISVFERLKKEFTL 299 Query: 303 YLADQGFDSLQEMVGLANN 321 +L + + S+ G N Sbjct: 300 FLQKKNYSSINSFKGKLKN 318 >UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VIM3_9BACT Length = 305 Score = 194 bits (492), Expect = 7e-48, Method: Composition-based stats. Identities = 74/318 (23%), Positives = 132/318 (41%), Gaps = 22/318 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L + +K +P ++S E G V KTI + PR Sbjct: 8 LQTSLGRLKVNSPVTVASGTF--ALENLDFIEQDHLGAYVCKTITRYPKKGNPPPRLYET 65 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 IG +N + + E+L LR LI S G + +++ ++ ++ Sbjct: 66 EAGLLNSIGLQNPGL--DKFIAEDLPVLRETLT----VPLIVSFSGSSLKEFVQMLECLE 119 Query: 125 -EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + G E N SCP + + G G P++V K C + + ++ K++PN+ D+ Sbjct: 120 KQEGISGYEVNVSCPNVENE--GIAFGIDPDVVNKLCALLSPLTERELIVKLSPNVTDIA 177 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +A AA+ GGA I+ INT+ + ++ + G + +KP+AL Sbjct: 178 VIAKAAEEGGATAISLINTIWGMA---IDYRNGKSRIKKGIGGYSG--IGIKPLALALTY 232 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + + P+ +GGI W+DA EF GA+ + + T V+ + GLS + Sbjct: 233 RAA---QAVKIPVIAMGGIYNWQDALEFFWAGASMIALGTANFI-DPLAVDKVYEGLSSF 288 Query: 304 LADQGFDSLQEMVGLANN 321 ++ L+++VG N Sbjct: 289 CLEKQLK-LKDIVGKVNK 305 >UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus RepID=C0WNB5_LACBU Length = 315 Score = 193 bits (491), Expect = 8e-48, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 123/319 (38%), Gaps = 15/319 (4%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L +F N ++ + K + GG V K+ SPR Sbjct: 7 SLKANIGKYRFNNVLLNAAGIRCATTDELTKILRSTAGGCVTKSATPQPREGNESPRMKA 66 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 +G N + H L+ L + D +I SI G + Q E+ + Sbjct: 67 TP------LGCINSMGLPNHGLDYYLK-FAEENQRKNDNQVILSIAGLSVDQNLEMLHQI 119 Query: 124 QEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 Q++ D + E N SCP + S + E V T + K+ P D+ Sbjct: 120 QDSLFDGLTELNLSCPNIKGE---SQIAYDFEAVRDILTKAFDFFTKDIGIKLPPYF-DL 175 Query: 183 CEVALAAKRGGADGIAAINTVKSITN-IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + A IA +N++ SI N + +N + ++ K G G VKP AL Sbjct: 176 HQFDQIADVLNEFPIAYVNSINSIGNGLIVNPETESVVLKPKGGFGGLGGDYVKPTALAN 235 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 ++ +R + + I G GGI++ D E +L GA +Q+ T +I + ++ L Sbjct: 236 VRGLRLRLK-PEIAIIGTGGIKSGRDVFEHILCGANVVQIGTAFGFEDVKIFDRISKELK 294 Query: 302 HYLADQGFDSLQEMVGLAN 320 +A++G+ SL + G Sbjct: 295 EIMAEKGYTSLDDFRGKLK 313 >UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UF20_9PROT Length = 378 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 63/347 (18%), Positives = 120/347 (34%), Gaps = 27/347 (7%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPR 60 DL++ G++F NP L++ N A G+ V TI PR Sbjct: 39 SKADLTVRIAGLEFANPLGLAAGFDKNA-TCFNGAMGLGFAHVEVGTITPKRQPGNPKPR 97 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-QQWEEL 119 L +E+ I + +NL A + + A+ + + + Sbjct: 98 VFRLPEENA-VINRYGFNSHGMDRVAKNLYATASKRVGILGVNVGANKTSNDPIDDYRQA 156 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-----------ST 168 ++ AD I N S P +L+ + Sbjct: 157 VAMLAPY-ADYITLNISSPNTPGLRNLQTKRHLADLLMAGFAGCREAGFEPACRSTGLRQ 215 Query: 169 LPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 P+ K+ P++ D+ + + GA GI A NT + G+ V+ + Sbjct: 216 KPIFLKIAPDLRHDDLATIVDSCVETGASGIIATNTTIARP-------TGLSGVH-AGEV 267 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 G SG + + + ++ + R + G+GG+ + A +L+GA +Q+ TG+ Sbjct: 268 GGLSGGPLFAASTGILAEVARLSQNR-LALIGVGGVSSGWQAYAKILVGADMVQLYTGLA 326 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSY 333 G + + L+ L G ++ E+ G ++ + Y Sbjct: 327 LEGPHLPNRILHELAQMLDADGATTIDEVKGQIVDSTAAIKHALGLY 373 >UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria RepID=PYRD_ANASK Length = 364 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 68/325 (20%), Positives = 117/325 (36%), Gaps = 22/325 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++ G+ F P L++ + + G+ V TI PR L Sbjct: 45 LAVRCMGLDFDGPVGLAAGFDKGDVALPG-LFGLGFSHVEIGTITPRPQPGNDRPRLFRL 103 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI-MGENEQQWEELAR 121 + +GF N A LAAL P + + + NE + Sbjct: 104 PEHRALLNRMGFNNEGMEACA---RRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLA 160 Query: 122 LVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-LPMLAKMTPN 178 ++ AD + N S P + L+ R + + P+L K+ P+ Sbjct: 161 CIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLLVKLAPD 220 Query: 179 IG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 + + E A GA GI A NT S ++ + + G SG ++ Sbjct: 221 LSPEALDEAVDVAIAAGAAGIVATNTTLSRAGVERHPRAA--------EAGGLSGAPLER 272 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 +A +++ PI G+GG+ E A + GA +Q TG++ G V + Sbjct: 273 LATDVVRRCYARA-AGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGLIYGGPGFVGRV 331 Query: 297 ASGLSHYLADQGFDSLQEMVGLANN 321 +GL+ L F +L + +G + Sbjct: 332 NAGLARLLERDEFSTLSDAIGADHR 356 >UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmida RepID=A7AUQ8_BABBO Length = 415 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 70/354 (19%), Positives = 129/354 (36%), Gaps = 43/354 (12%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 + V F NP +++ E+ + G+G V T+ P Sbjct: 59 PPVIQSRLKDVVFFNPIGMAAGYDK-QVEVPLQILRMGFGFVEVGTVLPLPQEGNPKPVM 117 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDK--VLIASIMGENEQQWEEL 119 L + I + + L +R+ + P +I +G+N + L Sbjct: 118 FRL-HDSKALINCCGFNSVGLEVAKARLKRVRKKQASDPLTKDFMIGVSVGKNRTG-DIL 175 Query: 120 ARLVQEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-------- 166 A V AD I N S P + Q E + A + Sbjct: 176 ADTVNAVKGVAPYADYIAINVSSPNTPNLRD----NQKREPLIAVISAARSALEIVNTEI 231 Query: 167 -----------STLPML-AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLN 212 +P+L K++P++ ++ ++A + DGI A NT + N+ Sbjct: 232 KSKGAEFNNTTKKVPLLLIKISPDVSRQELEDIADISLTHHVDGIIATNTTITRDNV--- 288 Query: 213 QKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL 272 + + + G SG+ +K ++ + + + E + PI GGI T +DA E + Sbjct: 289 --VPSDLKTAGNPKGGLSGRPLKTMSKKIVYDLYELTEGK-IPIIACGGISTAQDALEMI 345 Query: 273 LLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPA 326 GA+ Q+ T ++ G I M +GL+ L +G+ ++ E +G + P Sbjct: 346 EAGASLCQIYTALVYEGPGIPSRMKNGLADLLMKKGYLNVSEAIGAEHRRRKPT 399 >UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular organisms RepID=C9YAQ9_9BURK Length = 389 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 73/319 (22%), Positives = 125/319 (39%), Gaps = 28/319 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 D +T G++FPN +++ N G+G V T+ PR Sbjct: 77 DDPVTIAGLQFPNRVGMAAGLDKNAR-CIDGLGAMGFGFVEVGTVTPLAQPGNPKPRMFR 135 Query: 64 LVKEDT--GFIGFKNMEQIAEHPLEENLAALRR--LKEDYPDKVLIASIMGENEQQWEEL 119 L + + +GF N H L+ +A ++R L++ +L+ +G+N E Sbjct: 136 LPEANALINRLGFNN------HGLDAFIANVQRSALRQSKNPSLLLGLNIGKNAATPIEK 189 Query: 120 AR---LVQEAG----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGS 167 A L+ G AD I N S P + L+ A K G Sbjct: 190 ATDDYLICLDGVYPHADYITVNISSPNTKNLRSLQSDDALDALLGAIAERREQLAQKHGQ 249 Query: 168 TLPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLN-QKIGMPIVNGKS 224 P+ K+ P++ + +A KR G D +N + + + + + Sbjct: 250 RKPVFLKIAPDLEADQVAVIAATLKRYGTDSSGKVNNAWGVIGTNTTLSRGAVKGMPHAE 309 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 + G SG V + I Q+R +DFPI G+GGI + DA + GA +Q+ TG Sbjct: 310 EMGGLSGAPVLEKSNAVIGQLRAALG-KDFPIIGVGGIMSAADAVSKIKAGADAVQIYTG 368 Query: 285 IMQYGYRIVEDMASGLSHY 303 ++ G ++V+ A + + Sbjct: 369 LIYSGPQLVKGAAVAIKNL 387 >UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M0V6_ACIFD Length = 309 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 81/322 (25%), Positives = 125/322 (38%), Gaps = 21/322 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DLS+ + NP ++ G E+ A G V K++ +PR Sbjct: 1 MADLSVARGRLVLANPILTAAGCGGYGTELAAAVALERLGAHVVKSLTTVATEGNPAPRL 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + G N +A ++ LA D V + S+ G + + E R Sbjct: 61 APVPG------GMVNSVGLAGPGIDRWLAETWPSLADARIPVAL-SVWGRQPRDYGETVR 113 Query: 122 LVQEAGAD--MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 IE N SCP + + + P + AV+ P+L K++ N Sbjct: 114 RAARIAPSLVYIELNLSCPNLEADR--ALFAHDPNATARVVGAVRDEVATPILVKLSANT 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 + +VA AA GADG+ AINT+ + D G + G SG+AV+PIAL Sbjct: 172 DRIVDVAHAAVAAGADGLVAINTLFAQWYDD-----GREALGTARG-GGLSGRAVQPIAL 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + +R L PI G+GG+ T +D F+ GA +Q+ T + R + + Sbjct: 226 RAVADLRAA--LPTVPIIGVGGVATADDVERFVRAGADAVQIGTALFV-DPRRPVLVLAE 282 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 + LA G DS Sbjct: 283 IERRLARSGVDSWDRYARALRR 304 >UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVZ1_RUBXD Length = 304 Score = 190 bits (483), Expect = 8e-47, Method: Composition-based stats. Identities = 86/325 (26%), Positives = 144/325 (44%), Gaps = 34/325 (10%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 M+ +LS+ CGV+ P +S + E +A +G V+ KT+ P Sbjct: 1 MVAPELSVELCGVRLATPLIPASGTL--APEALGEAAGV-YGAVLPKTVTLRPRQGNPPP 57 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R IG +N +EE L AL + P + S+ GE +++ L Sbjct: 58 RVAESPAGMVNSIGLQNP------GVEEFLRALGAWEVGVP---VFVSVAGETVEEFALL 108 Query: 120 -ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLAKMTP 177 R+ + A IE N SCP + G P VE+ A +R + +P+LAK+ Sbjct: 109 CGRVAADGRAAAIELNLSCPNVERG--GQVFCAGPSAVEEVVAACRRAAPDVPLLAKLA- 165 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + + ALAA+ GADG+ +NTV ++ ++ + ++ G SG A+KP+ Sbjct: 166 -LEGVVQNALAAEAAGADGLTVMNTVPALA---VDARARRVLLR-----GGLSGPAIKPL 216 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 ALR + + + E P+ G GG+ + D AEF+L GA +QV + ++ Sbjct: 217 ALRAVYDVASAAE---IPVVGCGGVCSGADVAEFMLAGARAVQVGSAGFVRDP---AEIL 270 Query: 298 SGLSHYLADQGFDSLQEMVGLANNN 322 + YL ++G + E+ G Sbjct: 271 AEFERYLREEGLAA-SELAGALLPA 294 >UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=Plasmodium (Vinckeia) RepID=Q7RLG4_PLAYO Length = 512 Score = 190 bits (482), Expect = 9e-47, Method: Composition-based stats. Identities = 69/347 (19%), Positives = 128/347 (36%), Gaps = 51/347 (14%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDTGF 71 + F NPF +++ N G+ + TI PR V+ + Sbjct: 184 LNFINPFGVAAGFDKNGI-CIDSILKLGFSFIEIGTITPKPQKGNDKPRIFRDVE-NKSI 241 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG---- 127 I I + ENL + R+ +E+ DK+L I+G + + + +V + Sbjct: 242 INACGFNNIGCDKVTENLISFRKKQEE--DKLLSKHIVGVSIGKNKYTENIVDDLKYSIY 299 Query: 128 -----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL------------- 169 AD I N S P + + ++ VK+ Sbjct: 300 KIARYADYIAINVSSPNTPGLRDNQESNK----LKNIILFVKQEINKIEESGHNGENFWM 355 Query: 170 ------P-MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 P + K+ P++ + ++A G DG+ NT + +I Sbjct: 356 NTTKKKPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMIISNTTINKMDIK---------- 405 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQ 280 + + G SGK +K ++ I M + + PI GGI T DA E + GA+ Q Sbjct: 406 SFEDKKGGVSGKKLKDLSTNLISDMYIYTN-KQIPIIASGGILTGADALEKIEAGASVCQ 464 Query: 281 VTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 + + ++ G + + ++ L +G+ +L+E +G +NN + Sbjct: 465 LYSCLVFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHNNAKSLK 511 >UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular organisms RepID=PYRD_NITMU Length = 348 Score = 190 bits (482), Expect = 9e-47, Method: Composition-based stats. Identities = 65/314 (20%), Positives = 114/314 (36%), Gaps = 39/314 (12%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 S + G+ FPNP L++ N E G+G + T+ PR L Sbjct: 44 SRSIMGLTFPNPVGLAAGLDKNG-EHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLP 102 Query: 66 KEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA--- 120 + ++ +GF N + L + K ++ +G+N E A Sbjct: 103 QANSIINRMGFNNNG----------IEGLVANVKAMDYKGILGINIGKNFDTPVEKAVDD 152 Query: 121 -----RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKY-----CRAVKRGSTLP 170 R A I N S P + + L+ A + G P Sbjct: 153 YLICLRKAYRY-ASYITVNISSPNTPNLRQLQQATELDSLLGTLKLNQQRLADEHGKYTP 211 Query: 171 MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ ++ +A + DG+ A NT S ++ + G Sbjct: 212 LLVKIAPDLELPEIDSIAALLMKHRVDGVIATNTTLSRAGVE--------TLPHAREAGG 263 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG + A + ++ + PI G+GGI A E + GA+ +QV +G++ Sbjct: 264 LSGAPLAKRATSVVARLHHALQ-GALPIIGVGGIMDAAGATEKIAAGASLIQVYSGLVYR 322 Query: 289 GYRIVEDMASGLSH 302 G +V ++A L + Sbjct: 323 GPHLVGEIAQVLCN 336 >UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SB76_9ACTO Length = 377 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 66/301 (21%), Positives = 110/301 (36%), Gaps = 36/301 (11%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKE 67 T GV+FPNP L++ N + A G+G V T+ PR L Sbjct: 96 TVFGVRFPNPVGLAAGMDKNGLALPAWPA-LGFGFVEVGTVTAHAQPGNPRPRLFRLRDS 154 Query: 68 DT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQWE 117 + +GF N L + LAAL R P V + +G+++ + + Sbjct: 155 EAVINRMGFNNA---GAEALADRLAALPR-----PLGVPLGISLGKSKVTPLDEAVEDYL 206 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 R +++ G D N S P D L+ P+L K+ P Sbjct: 207 ASYRALKDHG-DYFAVNVSSPNTPGLRSLQDRSHLDALLAALVGE------KPVLVKIAP 259 Query: 178 NIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 ++ + + E+ GA G+ A NT + + + + G SG+ + Sbjct: 260 DLTEPAVAELLEVCLDRGAAGVIATNTTLARDGLAPADR------ERAAEAGGLSGRPLT 313 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 A + + P+ G+GGI +DA GA+ LQ+ TG + G + Sbjct: 314 ARAREMVAFVHRETG-GRLPVIGVGGILHPDDATRMFDAGASLLQLYTGFIYRGPALTRA 372 Query: 296 M 296 + Sbjct: 373 I 373 >UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XQ80_HIRBI Length = 362 Score = 189 bits (480), Expect = 2e-46, Method: Composition-based stats. Identities = 64/339 (18%), Positives = 119/339 (35%), Gaps = 45/339 (13%) Query: 3 TKDLSIT--FCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 ++ L + G+ PNP +++ N G G V T+ + P Sbjct: 44 SERLKVHLPISGLDLPNPLGIAAGFDKNADAFVPSLA-LGCGFVECGTVTPQLQDGNPKP 102 Query: 60 RFDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---- 113 R L ++ +GF N + + RLK ++ ++ + +G N+ Sbjct: 103 RLFRLKEDGGVINRMGFNNSGLDS---------FVHRLKNGAANQGVVGANVGANKTSEG 153 Query: 114 ----QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----K 164 + + + V + A I N S P + L+ + + Sbjct: 154 EKRVGDYVDGIKAVWQYCA-YITLNISSPNTPGLRGLQNKSDLSALLTAASETILEMEDR 212 Query: 165 RGSTLPMLAKMTPNIG-----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 + P+ K+ P+I D+ + L AK G G+ NT + + Sbjct: 213 HKTKRPVFLKIAPDIDEEAIRDIVDTVLLAK--GMTGLIVSNTTIERPSFLQS------- 263 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 G SGK + + + ++Q+ I G GGI + A + GA Sbjct: 264 -ENAKQTGGLSGKPLFEKSTQVLKQVA-RIADGQLDIIGAGGIHDAKSAYLKIRAGAHCF 321 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 Q+ + ++ G ++ ++ +GL L GF L E VG Sbjct: 322 QLYSALVYEGAALIPEILNGLDQLLEADGFSQLSEAVGA 360 >UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9F3A8_SORC5 Length = 407 Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 70/327 (21%), Positives = 121/327 (37%), Gaps = 27/327 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 +++ G+ FP+P ++ G+G V T+ A P Sbjct: 77 RIAVRTMGLDFPSPLGVA-GGFDKDARRARALAALGFGFVELGTVTAQPQAANPPPNLFR 135 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN----------- 112 L D I + E L L R + SI G++ Sbjct: 136 LP-ADRALINRLGFPNQGAARVTERL--LGRGGTAAVGVPVGISI-GKSRVAPLDPIEPA 191 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPM 171 + R + A AD + N S P + L+ R + + LP+ Sbjct: 192 IDDYLASFREARRA-ADFVVINVSSPNTKDLRAMQGPAIARALLSAIARENRAAGAPLPL 250 Query: 172 LAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 L K+ P++GD + + + G G+ A NT + + P G Sbjct: 251 LIKVAPDLGDEELEALLAVVEEVGLAGVIATNTTVRRDGLATS-----PADVEAMGAGGL 305 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG ++ +L ++++R + + G GGIE+ E A + L GA +Q+ TG + G Sbjct: 306 SGPPLRQRSLAMVRRIRARLG-SNVTVIGAGGIESAEHAMDQLQAGADLVQIYTGFIYGG 364 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMV 316 + ++A GLS +A G S+Q++V Sbjct: 365 PLLPAEIARGLSDLVARSGARSIQDLV 391 >UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CE91_THET1 Length = 376 Score = 188 bits (478), Expect = 3e-46, Method: Composition-based stats. Identities = 62/337 (18%), Positives = 117/337 (34%), Gaps = 29/337 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 L ++ GV+ NP + + + Y G+ V T+ +PR Sbjct: 56 PRLKVSLAGVQLENPLIVGAGWDKSGIS-IRALYALGFASVEVGTVTPRPQPG-NPRPRQ 113 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-------- 115 V I + NL + + D + + +G+N+ Sbjct: 114 FVLSSGVVINRLGFNNPGADAVAANLESYKS------DNIPVGISIGKNKDDPEDRAPLA 167 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAK 174 + E+AR + G N S P + + + G+ P+ K Sbjct: 168 YAEVARKLYPYG-SYFVINVSSPNTPGLRSLQRKEALLSIAQSVLDVMDSYGARKPLFIK 226 Query: 175 MTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG- 231 + P + ++ E+ + G G+ A NTV D+ + G + G SG Sbjct: 227 IAPELSYQEVDEILDVVLQLGLAGVVATNTVALG---DVKARYGE---GWRLQPGGLSGD 280 Query: 232 -KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 + + ++ + + + + I G+GG++ A E +L GA +QV T I G Sbjct: 281 DEVFRHMSTSKVAYIYSQTK-GSIDIIGVGGVKDAHTALEKILAGATAVQVVTAIRSEGL 339 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 + GL +L G S+ +VG + + + Sbjct: 340 AVAARTNLGLLEWLDKNGVKSISNVVGARYEDFLDTK 376 >UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodospira halophila SL1 RepID=PYRD_HALHL Length = 342 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 110/308 (35%), Gaps = 37/308 (12%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKE 67 G+ FPNP L++ + E G+G + T+ PR + + Sbjct: 46 RVMGIDFPNPVGLAAGFDKDG-EYMDVLEQLGFGFLELGTVTPRAQPGNPQPRVFRIPEH 104 Query: 68 DT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA--RLV 123 + +GF N + L R E + ++ +G+N E A Sbjct: 105 EALINRMGFNN----------QGAEPLVRRLEVSRHRGVVGINIGKNRDTPPERAVEDYA 154 Query: 124 QEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLPMLA 173 Q G AD + N S P G L+++ KR + +P++ Sbjct: 155 QALGMVYGVADYVAVNLSSPNTPGLRDLQHEGALRNLIDRLQTERKRLAELHDKRVPLVV 214 Query: 174 KMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P+ G++ DGI A NT T ++ + G SG Sbjct: 215 KIAPDWEAGELDATLDILLERRVDGIVATNTTLGRTGVEQTPQ--------ARESGGLSG 266 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 ++ A ++Q+ R + GGI + ED L LGA +Q+ TG++ G Sbjct: 267 APLREQAEWVLEQVAAR-RDRRTALIAAGGIMSGEDVTRRLDLGADLVQLYTGMIYRGPG 325 Query: 292 IVEDMASG 299 +V++ Sbjct: 326 LVQEAVRA 333 >UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria RepID=PYRD_VEREI Length = 360 Score = 187 bits (476), Expect = 5e-46, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 115/318 (36%), Gaps = 34/318 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 T D I G++FPN L++ N G+G V T+ PR Sbjct: 45 TVDDPIELAGLRFPNRVGLAAGLDKNAR-CIDALGAMGFGFVEAGTVTPQAQPGNPRPRM 103 Query: 62 DHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVL-IASIMGENEQQWEE 118 L + +GF N L+ + L++ + L + +G+N Sbjct: 104 FRLPEARALINRLGFNNA------GLQAFVHNLQQSRLRAAGSALRLGLNIGKNASTPMA 157 Query: 119 LARLVQEAG-------ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRG 166 A A AD + N S P + L+ A + G Sbjct: 158 QASSDYLACLEGVYPHADYVALNISSPNTQNLRTLQGDAALDHLLGAIAERRATLAARHG 217 Query: 167 STLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 +P+ K+ P++ + + +A +R G DG+ A NT + + Sbjct: 218 RRVPVFVKIAPDLDEAQLSLMAATLQRHGIDGVIATNTTIDRAVVQGQR--------HAQ 269 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG V + + I Q+R + FPI G+GGI + EDA + GA +Q+ TG Sbjct: 270 ESGGLSGAPVLQASNQVIGQLRAALG-KGFPIIGVGGIMSAEDAVSKIRAGADLVQIYTG 328 Query: 285 IMQYGYRIVEDMASGLSH 302 ++ G +V A + Sbjct: 329 LIYEGPALVVQAARAIKA 346 >UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=PYRD_AKKM8 Length = 348 Score = 187 bits (476), Expect = 5e-46, Method: Composition-based stats. Identities = 62/312 (19%), Positives = 114/312 (36%), Gaps = 36/312 (11%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVK 66 + G+KFPN L++ + + G+G V T+ PR L+ Sbjct: 50 VEILGMKFPNRVGLAAGMDKE-ADTVSAFGQAGFGFVEVGTLTPRPQPGNEKPRLFRLIP 108 Query: 67 EDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEEL 119 + +GF N E A + ++ ++ +G+N+ ++ Sbjct: 109 QKAIINRMGFNN---------EGIAAGVENIRSATRFHGVLGVNIGKNKITPNEDAAQDY 159 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGSTLPML 172 ++ A AD I NFS P + L+ A + G +P+ Sbjct: 160 LTCLRAAWPVADYIAINFSSPNTPGLRDLQAAEPAARLLASLKSEQSNLAAETGRHVPIF 219 Query: 173 AKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ D + E++ G DG+ A NT S ++ N + G S Sbjct: 220 MKVAPDVTDEHIAELSRVFLDEGLDGLIATNTTLSRVGVEANPR--------HEEAGGLS 271 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G + + I + + PI G+GGI DA + GA+ +Q+ TG + G Sbjct: 272 GAPLTERSTEVIGAFASELK-GRIPIIGVGGIMNGVDAVAKIKAGASLVQLYTGFVYRGP 330 Query: 291 RIVEDMASGLSH 302 ++ + + Sbjct: 331 DLIRECVEAMKA 342 >UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidobacteriaceae RepID=C6A9A6_BIFLB Length = 386 Score = 187 bits (475), Expect = 6e-46, Method: Composition-based stats. Identities = 81/326 (24%), Positives = 126/326 (38%), Gaps = 31/326 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G+ F NPF LS+ NC +M A G+G + A P F L Sbjct: 77 LETNVMGINFANPFGLSAGLDKNC-DMAAVLDHAGFGFETVGSTTSRPCAGNPRPWFHRL 135 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + D+ + ++ +E A RR + L SI N+ Q +L ++ Sbjct: 136 PEYDSMMVHVGLANDGSDVVIERAEDAWRRTQS----MQLSVSIARTNDDQVGDLNEGIE 191 Query: 125 EAGADM---------IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLAK 174 + M +E N SCP T +G +S E ++K A+ R P L K Sbjct: 192 DYCISMERAAGRTAMVEVNVSCPNTT---VGEPFTESAENLDKLFAALDRIERPQPTLVK 248 Query: 175 MTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 M N E G+ N K T +D +P K + G SG Sbjct: 249 MPLNKPWPQFKEFLDVLAAHNVQGVTIANLQKDRTGLD-----DIP----KDWLGGLSGG 299 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + I++ R F I+G+GG+ T E A E + G++ + + +M G + Sbjct: 300 PCTVASTELIRRTYAEYGDR-FAIAGVGGVFTPEQAYEKIRAGSSLIMFISSLMYRGPQQ 358 Query: 293 VEDMASGLSHYLADQGFDSLQEMVGL 318 + + GL+ L GF S+ E VG+ Sbjct: 359 ITVLKRGLAKLLRRDGFGSVAEAVGV 384 >UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma RepID=C4QIG2_SCHMA Length = 379 Score = 187 bits (474), Expect = 8e-46, Method: Composition-based stats. Identities = 63/318 (19%), Positives = 119/318 (37%), Gaps = 31/318 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L G++F +P L++ + + G+ + T+ PR Sbjct: 71 PQLKCKVFGLEFDHPIGLAAGFDKDGKAFMG-LLNAGFSHIEVGTVTPNPQLGNARPRIF 129 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLK-EDYPDKVLIASIMGENEQQW--- 116 +++ GF + A + RLK + + +I +G N+ Sbjct: 130 RWTEKEAVVNRCGFNSDGHDAVY---------ERLKDRPWEGRGVIGVNLGCNKTSADPT 180 Query: 117 EELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL-PMLA 173 + V++ G AD + N S P + +L+ K A + S P+L Sbjct: 181 ADYVAGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLRDLLSKVLAARNQLSKKTPILL 240 Query: 174 KMTPN-----IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS--- 225 K++P+ + D+ EVAL +K DG+ NT + + PI Sbjct: 241 KISPDENDQNLKDIVEVALDSKTR-IDGMIISNTTLTTYEEAV-ACGAAPIPGNNKQNVV 298 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SG+ + + ++++ + P+ G+GGI EDA L GA+ +Q+ T Sbjct: 299 YGGLSGRPLFEKSTDCLRKVSALTK-GAIPLIGVGGISCGEDALSKLNAGASLVQLYTSF 357 Query: 286 MQYGYRIVEDMASGLSHY 303 + G + +A ++ Sbjct: 358 VYQGPPVAHKVAREINKL 375 >UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaproteobacteria RepID=PYRD_SHEWM Length = 340 Score = 186 bits (473), Expect = 9e-46, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 126/310 (40%), Gaps = 39/310 (12%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL-- 64 + F GV FPNP L++ + E + G+G + T+ PR L Sbjct: 47 VEFMGVTFPNPVGLAAGMDKDG-ECIDGFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKP 105 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR--- 121 K +GF N ++ +A L+ K LI +G+N+ E + Sbjct: 106 AKGIINRMGFNN------KGVDNLIANLKAAKS----GALIGVNIGKNKDTPVEQGKDDY 155 Query: 122 -----LVQEAGADMIECNFSCPQMTSHAM---GSDVGQSPELVEKYCR--AVKRGSTLPM 171 V E A I N S P G + ++ + A K G +P+ Sbjct: 156 LICMDKVYEY-AAYIAVNISSPNTPGLRSLQYGDLLDDLLGSLKAKQKDLAQKHGKYVPI 214 Query: 172 LAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ D + ++A + + DG A NT S + G+ + + G Sbjct: 215 ALKIAPDLSDEEIQKIADSLIKNQFDGAIATNTTLS--------RDGVSGLMNANETGGL 266 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + ++ I+++ + + PI G+GGI + DA + L GA+ +Q+ +G + G Sbjct: 267 SGKPLNLLSTSVIKKLSSCLNGQ-IPIIGVGGINSAADAIDKLDAGASMVQIYSGFIYQG 325 Query: 290 YRIVEDMASG 299 ++++D+ Sbjct: 326 PKLIKDIIEA 335 >UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B240E Length = 338 Score = 186 bits (473), Expect = 1e-45, Method: Composition-based stats. Identities = 75/335 (22%), Positives = 130/335 (38%), Gaps = 35/335 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 K L GV F NP LS+ N ++ D G+G ++ + P F Sbjct: 7 KSLQQEIDGVNFRNPIGLSAGFDKN-VQLSPLMEDVGFGFASGGSVTLEPRKGNLRPWFH 65 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ------- 115 L K + + + M + + A R + P V +A + ++ + Sbjct: 66 RLPKTKSVVV-YAGMPNYGLEKIGNYVKANRIKIQSMPTVVSVAVVANKSTKDKLGPKVP 124 Query: 116 WEELARLVQEA--------GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-G 166 E + + V++A A ++E N SCP G + PE +E + + Sbjct: 125 EEYIVKDVKKAVNYIIDNKLASIVEINISCPN-----AGKESFIYPETLEILLKEIDTID 179 Query: 167 STLPMLAKMTPNIGDMCEVALAAK---RGGADGIAAINTVKSITNIDLNQKIGMPIVNGK 223 +P KM P++ D+ + K + G+ N VK T +++ + I Sbjct: 180 RNIPFWIKM-PHLYDINQFDSLLKVIVKHNIQGVTIANLVKDRTKVEIKDPLTDEIR--- 235 Query: 224 SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 G SG+ + +L I+ + + I G+GGI + EDA + GA+ + + T Sbjct: 236 ---GGLSGEPTRKHSLELIRYAYKNYGNK-LTIVGVGGIFSAEDAYAKIKAGASLVGLIT 291 Query: 284 GIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G+ G +V L L + GF S+ E VG Sbjct: 292 GLFFEGPHLVGRANRELVKLLKNDGFSSISEAVGA 326 >UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomycetales RepID=PYRD_STRAW Length = 368 Score = 186 bits (473), Expect = 1e-45, Method: Composition-based stats. Identities = 69/334 (20%), Positives = 118/334 (35%), Gaps = 30/334 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 K+L G++ PF L++ N G+ V T+ R Sbjct: 48 KELRTEAFGLRMHGPFGLAAGFDKNAV-AVDGMSMLGFDHVEIGTVTGEPQPGNPKKRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 LV + +GF N A A+ R ++ +G+ + + Sbjct: 107 RLVPDRALINRMGFNNEGSAAVAARLAAREAVFR--------TVVGVNIGKTKVVPEEEA 158 Query: 116 WEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST---LP 170 ++ + + AD + N S P L+ A R T +P Sbjct: 159 ADDYVKSTERLARHADYLVVNVSSPNTPGLRNLQATEALRPLLSAVREAADRTVTERRVP 218 Query: 171 MLAKMTPNIGDMCEVALAA--KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ D A+A G DGI A NT + + L + + G Sbjct: 219 LLVKIAPDLADDDIDAVADLAVELGLDGIIATNTTIAREGLGLKSEPTLV-----KETGG 273 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG +K +L + ++ R + G+GGIE EDA + +L GA +Q + + Sbjct: 274 LSGAPLKARSLEVLSRLYARVGDR-ITLVGVGGIENAEDAWQRILAGATLVQGYSAFIYE 332 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 G + GL+ L + +L + VG Sbjct: 333 GPFWGRAIHKGLAARLRTSPYATLADAVGADVRK 366 >UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding n=1 Tax=Treponema denticola RepID=Q73P17_TREDE Length = 591 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 77/268 (28%), Positives = 120/268 (44%), Gaps = 15/268 (5%) Query: 23 SSPVGNCYEMCAKAYD-TGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIA 81 S + + D G+G V K+ R L + + G F N + Sbjct: 31 SGVLSTKPNLIRYCADELGFGLVTTKSFQVLP--NPGNREPILCEPELGC--FGNSVGLR 86 Query: 82 EHPLEENLAALRRLKEDYP-DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQM 140 +E+ + L+ L+ + D +L S+ N + + L + +E AD E NFSCP Sbjct: 87 NCGMEQAVKELKELRSSWKTDSILNVSLSASNPEDFISLLKGFEEL-ADCFELNFSCPH- 144 Query: 141 TSHAMGSDVGQSPELVEKYCRAVKRGST---LPMLAKMTPNIGDMCEVALAAKRGGADGI 197 S G+ +G P + +Y + +K+ +P+ K+TPN+ D+ +A A GADGI Sbjct: 145 ASAGFGASIGCDPAIAAEYVKIIKKALPDCAVPIFVKLTPNVEDIGAIASAVIEAGADGI 204 Query: 198 AAINTVKSITNIDLNQKIGMPIVNGK-SSISGYSGKAVKPIALRFIQQMRTHPELRDFPI 256 AINTV + + G PI+ K G SG V P AL I Q+R + PI Sbjct: 205 TAINTVG--PKVYIEPHSGKPILQNKLGGKGGMSGAWVFPRALECIGQIRKAVG-EEIPI 261 Query: 257 SGIGGIETWEDAAEFLLLGAATLQVTTG 284 G+GG+ T AAE + GA + + + Sbjct: 262 IGMGGVMTGAQAAELVRAGADIIGIGSA 289 >UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (class) RepID=B9L4A8_THERP Length = 374 Score = 186 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 128/335 (38%), Gaps = 43/335 (12%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 + L + + FPNP L++ N E A + G+G V T+ PR Sbjct: 63 ERLRVEVGDLTFPNPIGLAAGVDKN-AEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLW 121 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 +++T +GF + A R + +P V I +G+N W L Sbjct: 122 RFPEDETLVNALGFPSDGVAAVRA--------RLVGRWFPGPVGI--NLGKNA--WTPLE 169 Query: 121 RLVQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKY------CRAVKR 165 + V + A D + N S P + +++ A++R Sbjct: 170 QAVVDYCATLVALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQR 229 Query: 166 GSTLPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK 223 P+ K++ ++ G + + A GADG+ NT +ID + + Sbjct: 230 ARPRPLFVKVSLDLDAGALADAIEIAVAVGADGLILGNT-----SIDPSLRPA----GAG 280 Query: 224 SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 + G SG+ ++ A+ + + +GG+ +D + L LGA +QV T Sbjct: 281 ALPGGVSGRPLRKRAVELLSNAADRAG-GRLALISVGGVLETDDVIQRLRLGADLVQVYT 339 Query: 284 GIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G++ G + + GL YL +QG S++ + G Sbjct: 340 GLVFRGPALPAVLLRGLLRYLDEQGLPSVRALRGR 374 >UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=PYRD_METI4 Length = 348 Score = 186 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 110/309 (35%), Gaps = 33/309 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G++FPNP L++ N G+G V T+ +PR L Sbjct: 49 LPKELWGMQFPNPVGLAAGFDKNGV-GLRAWESFGFGFVEIGTVTPLPQEGNPAPRLCRL 107 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQW 116 KE N + L+++ K+ + +G+N + + Sbjct: 108 PKEGA----LWNSLGFPSQGAQRVAERLKKVFLSGRPKIPVGINIGKNRHTPLEETIEDY 163 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 ++ ++ G D N S P + EL+ + P+L K+ Sbjct: 164 KKCFSYFKDLG-DFFVVNVSSPNTPGLKSLQQ-KRFLELLFDRLNPLNSSPRKPLLVKIA 221 Query: 177 PNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P+I ++ + R + GI NT+ P G SGK + Sbjct: 222 PDIELKNLAGILEVLLRNESVGIVIANTL--------------PAKGPGGKEGGLSGKPL 267 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + ++L I+ ++ PI G+GGI + +DA E + GA +++ TG + G Sbjct: 268 RELSLGLIRFVKKET-AGRLPIIGVGGIFSSKDAFEKMEAGADLIEIFTGFVYNGPSFPA 326 Query: 295 DMASGLSHY 303 ++ L Sbjct: 327 NLCRELERL 335 >UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobaceae RepID=PYRD_SULAC Length = 291 Score = 186 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 80/318 (25%), Positives = 132/318 (41%), Gaps = 31/318 (9%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAK-AYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 I GV F +P ++S V E + KT+ + SP F + Sbjct: 2 IQVAGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKIS 61 Query: 66 KE-DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 IG N + LR L E LI SI G N ++ + + Sbjct: 62 DNCYLNAIGLGNPG----------IQILRDLGEIKCK--LIISIGGSNVNEYIDAVSKIN 109 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 + MIE N S P + VE+ + VK P+ K+ P ++ E Sbjct: 110 DIPV-MIELNVSSPNRRGFG-----ESNLTYVEEIVKNVKSIVKKPVFVKLGP-WDNIVE 162 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 +A A GADG+ INT+K + ID+ PI++ G SGK + +A+R I Sbjct: 163 IAGRALSAGADGLTLINTLKGML-IDVEDF--KPILS--YGTGGISGKCIHALAVRVIHD 217 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 + E I G+GG+ W DA E + +GA + + T +++ G+ ++ ++ G+ YL Sbjct: 218 VFKEYE---PEIIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGIGTYL 274 Query: 305 ADQGFDSLQEMVGLANNN 322 ++G ++E+ G+ Sbjct: 275 EEKGLK-VEEIRGIGVKR 291 >UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondrial n=4 Tax=Plasmodium RepID=PYRD_PLAF7 Length = 569 Score = 182 bits (463), Expect = 2e-44, Method: Composition-based stats. Identities = 68/374 (18%), Positives = 126/374 (33%), Gaps = 74/374 (19%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVK 66 + F NPF +++ N G+ + TI PR V+ Sbjct: 210 TNIKHLDFINPFGVAAGFDKNGV-CIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVE 268 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 I + + ENL R+ +E+ DK+L I+G + + ++ +V + Sbjct: 269 S-RSIINSCGFNNMGCDKVTENLILFRKRQEE--DKLLSKHIVGVSIGKNKDTVNIVDDL 325 Query: 127 G---------ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR------------ 165 AD I N S P + G+ ++ + Sbjct: 326 KYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDEST 385 Query: 166 ----------------------------------GSTLP-MLAKMTPNI--GDMCEVALA 188 P + K+ P++ E+A Sbjct: 386 YNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADV 445 Query: 189 AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH 248 DG+ NT I +I + ++ G SG +K I+ +FI +M + Sbjct: 446 LLETNIDGMIISNTTTQINDIK----------SFENKKGGVSGAKLKDISTKFICEMYNY 495 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 + PI GGI + DA E + GA+ Q+ + ++ G + + L+H L +G Sbjct: 496 TN-KQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRG 554 Query: 309 FDSLQEMVGLANNN 322 + +L+E +G ++ Sbjct: 555 YYNLKEAIGRKHSK 568 >UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVX7_9BACT Length = 356 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 120/314 (38%), Gaps = 32/314 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 L G++FPNP L++ N E + G+G V T+ A PR Sbjct: 47 HPSLEREVFGLRFPNPIGLAAGFDRNG-EAFRELSALGFGFVEIGTVTPQPQAGNPRPRI 105 Query: 62 DHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN------- 112 L + G N A+ +L+ + D+++I +G+N Sbjct: 106 FRLPADRAIINRSGLNNKGLY---------KAIAQLRHRH-DRLIIGGNIGKNTLTQPSQ 155 Query: 113 -EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-RGSTLP 170 + ++ R + + D N C ++ + +++ + + P Sbjct: 156 VAADYLKMFRNLYQY-VDYFSINVCCDNCADGSVSHNKAHLMNILQPLFDFRRGQNQYRP 214 Query: 171 MLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K++P++ D + EV DGI A+N S ++ +++ I Sbjct: 215 ILLKISPDLPDPLIDEVTDLMLSTPLDGIVAVNGTFSRKGLETDEETLDEI-----GSGR 269 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG + A+ ++++ +PI G+GG+ D L GA+ +Q+ TG + Sbjct: 270 LSGAPLTQRAIEVVRRIHRRSH-GAYPIIGVGGLMNARDVKAMLAAGASLVQLYTGYIYE 328 Query: 289 GYRIVEDMASGLSH 302 G +V+++ L Sbjct: 329 GPSLVKEICRALID 342 >UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5N0_THEAS Length = 316 Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 78/319 (24%), Positives = 140/319 (43%), Gaps = 24/319 (7%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVK 66 ++ G+ +P ++S + E+ + G G + K I R + LV+ Sbjct: 17 NVDLNGLGLSSPVVVASGVLPMDGEVWSSME--GVGLICTKGITLEP--RAGNRGERLVE 72 Query: 67 EDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 +G + +E + LE L L R + V +S+ + EEL + + Sbjct: 73 TPSGLLNSIGLENPGIDRFLEAILPDLLRSRRSLGLNVAFSSL-----GELEELIGRIGD 127 Query: 126 AGADM--IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 A + +E N SCP + G+ G+SPE + R + + AK+TP D+ Sbjct: 128 RAASVEVLELNLSCPNVD--REGAVWGESPERTFEAVRLARSLWPRSVWAKLTPQAPDVA 185 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 VA AA+ GA + NT +++ + G P+ K ++G SG AV P+ LR + Sbjct: 186 AVARAAEEAGAHCLVVANTWLGA---EVDLEAGAPVF--KRVVAGLSGPAVLPLTLRLLF 240 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 Q+ P+ GGI + +DA + ++ GA+ +QV T + + ++ G+ + Sbjct: 241 QLYPKV---SVPLVACGGICSPQDALKAMMAGASAVQVGTQLFR-DLGCCGEILEGIRSF 296 Query: 304 LADQGFDSLQEMVGLANNN 322 L +G S+ +VG A+ Sbjct: 297 LDSRGL-SVSRLVGCAHRA 314 >UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobacillales RepID=A0NIQ6_OENOE Length = 329 Score = 180 bits (457), Expect = 7e-44, Method: Composition-based stats. Identities = 58/325 (17%), Positives = 115/325 (35%), Gaps = 20/325 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIA-NEVSP 59 + D + F + F ++ E + + G V+ K+ P Sbjct: 16 VKMDYTTKIANQVFHHLFINAAGVYCQTVEELEQIQNAPCAGAVITKSATAKERSGNSEP 75 Query: 60 RFDH--LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 R+ + +G N+ ++ L + LK L SI+G ++ + Sbjct: 76 RYFENSVEHNTINSMGLPNL------GIDYYLNYV--LKHSLKLPTLF-SIVGLSQSEII 126 Query: 118 ELARLVQEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 + + +Q +G + E N SCP + + + V + P+ K+ Sbjct: 127 DNLKKLQASGFSGLTELNLSCPNVPGKP---QIAYDFTATREILDNVFAFYSKPLGVKLP 183 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITN-IDLNQKIGMPIVNGKSSISGYSGKAVK 235 P D A + +N + S+ N + ++ + P++ K G GK +K Sbjct: 184 PYF-DTAHFDQIASILNDYPLTYVNAINSVGNGLVIDPETDTPVIKPKDGFGGLGGKQIK 242 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 AL ++ +R I GG+ D + LL GA + + + + G + Sbjct: 243 ATALANVRALRQRL-YPQIKIIATGGVTNGRDVYDHLLCGADLISIGSQLEIEGPTVFAR 301 Query: 296 MASGLSHYLADQGFDSLQEMVGLAN 320 + L AD+G L+++ G Sbjct: 302 LEKELEEIFADKGITDLRQVRGKLK 326 >UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia RepID=B1ZSY3_OPITP Length = 352 Score = 180 bits (457), Expect = 8e-44, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 104/296 (35%), Gaps = 31/296 (10%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-FFIANEVSPRFDHLVK 66 + G+ FPN L++ N A A G+G V TI PR Sbjct: 56 VRAFGLDFPNAIGLAAGFDKNATAWPALAA-LGFGHVEIGTITALAQPGNEKPRVFRFPA 114 Query: 67 EDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEEL 119 E +GF N E L ++ + +G+++ Q ++ Sbjct: 115 EKAVINRMGFNNEGS------EAIARRLAHQPGVGQRRIPLGINLGKSKVTDLDQAAQDY 168 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-RGSTLPMLAKMT 176 AD I N S P D + EL+ A + R +P+L K+ Sbjct: 169 LTSFGRLADHADYIALNVSSPNTPGLRQLQDEARVRELLGAISAANRARPRPVPLLLKIA 228 Query: 177 PNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ + V A DGI A NT + + G SG+ + Sbjct: 229 PDLTFPQIDAVLAALMEFRFDGIIATNTTLARPG----------PFAAANQAGGLSGRPL 278 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 + + I + + PI G+GGIE AAE L GA LQ+ TG++ G Sbjct: 279 RRRSTEIINYIARATAGK-LPIIGVGGIEDGASAAEKLDAGATLLQIYTGMIYRGP 333 >UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Plasmodium vivax RepID=A5K1N1_PLAVI Length = 572 Score = 180 bits (457), Expect = 8e-44, Method: Composition-based stats. Identities = 70/375 (18%), Positives = 122/375 (32%), Gaps = 78/375 (20%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKE 67 G+ F NPF +++ N G+ + TI PR ++ Sbjct: 213 EIKGLNFINPFGVAAGFDKNGV-CIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLET 271 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKED--YPDKVLIASIMGENEQQ---WEELARL 122 I + + +NL R ++ + L+ +G+N+ ++L+ Sbjct: 272 -RSIINSCGFNNMGCDEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQDLSYC 330 Query: 123 VQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL----------- 169 + + G AD I N S P Q E + + VK Sbjct: 331 IGKIGRYADYIAINVSSPNTPGLRD----HQKGERLHGIIQRVKEEVAKLDGGGAPLGGA 386 Query: 170 ---------------------------------------P-MLAKMTPNI--GDMCEVAL 187 P + K+ P++ G+ +A Sbjct: 387 TTGGAAMGGATTGEAVVGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIAN 446 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 DG+ NT NI + + G SG+ +K ++ I QM Sbjct: 447 VLLNAEVDGMIICNTTTQKFNIK----------SFEDKKGGVSGEKLKGVSTHMISQMYN 496 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 + + PI GGI T EDA E + GA+ Q+ + ++ G + + L H L + Sbjct: 497 YTNGK-IPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQR 555 Query: 308 GFDSLQEMVGLANNN 322 G+ L + VG A+ Sbjct: 556 GYYKLGDAVGRAHRR 570 >UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteobacteria RepID=PYRD_DICNV Length = 337 Score = 180 bits (456), Expect = 1e-43, Method: Composition-based stats. Identities = 63/307 (20%), Positives = 113/307 (36%), Gaps = 34/307 (11%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVK 66 I G FPN L++ N + G+G + T PR L + Sbjct: 43 IHLLGHTFPNRLGLAAGLDKNAV-AISAFDRLGFGFIEVGTATPRPQSGNPKPRLFRLPE 101 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQWEE 118 I L + +AA+++ + LI +G+N+ + Sbjct: 102 H-QAIINCMGFNNDGVVALCQQVAAVKK-----RTRALIGINIGKNKLTPNERAADDYL- 154 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLPMLA 173 +A AD + N S P EL+++ + S T+P+L Sbjct: 155 IAMSTAYPYADYLAINISSPNTVGLRDLQHGAALCELLQRLKTERDKLSAVYEKTVPLLV 214 Query: 174 KMTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P+ + E+ + G DGI A NT T + ++ G SG Sbjct: 215 KIAPDNEREQLDEMLSIIEDSGIDGIIATNTTLDKTAVTGHRYAD--------EQGGLSG 266 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 K + + + I +R L D P+ GG+ + +D L GA +Q+ +G++ +G + Sbjct: 267 KPLTEKSTKIIAHIRER--LPDLPLIASGGVMSADDYYAKLEAGADLVQIYSGLIYHGPQ 324 Query: 292 IVEDMAS 298 +++D Sbjct: 325 LIKDCLR 331 >UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotogaceae RepID=PYRD_THEP1 Length = 270 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 128/297 (43%), Gaps = 38/297 (12%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKEDTGF 71 ++ P L S P G E GGV+ KT+ +PR + D Sbjct: 2 LELKPPLVLLSGPAGFG-EYLKLMDHRYVGGVLLKTVTLHPKEGNPTPR---MADSDFYV 57 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGAD-- 129 I +E H EN+ L +IAS+ G++ +++ E+AR+ ++ AD Sbjct: 58 INRIGLENPGIHAFVENIPELP--------VPMIASLGGDSFEEYLEVARVFKKV-ADRF 108 Query: 130 -MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP---MLAKMTPNIGDMCEV 185 +E NFSCP + G + ++ E +K +++ LP ++AK+ + + Sbjct: 109 YAVEFNFSCPNVKEG--GLSIVKNAEEWKKLLNTLRKE--LPDSFLIAKVGVEGIFVEDA 164 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A + G DGI +NTV+ G+ + G SG +KPIALR + ++ Sbjct: 165 AEFVMKTGWDGITLVNTVR-----------GLHFEKDTMILGGLSGPVLKPIALRAVYEV 213 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + + GG+ + +DA EFL +GA + V + + +VE++ L Sbjct: 214 KKR--FPELFVIASGGVYSVKDAEEFLKVGADVIGVGSALF-KDPGVVEEIGKYLLE 267 >UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacterium KB13 RepID=B6BWI2_9PROT Length = 335 Score = 177 bits (448), Expect = 9e-43, Method: Composition-based stats. Identities = 58/307 (18%), Positives = 115/307 (37%), Gaps = 38/307 (12%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDT- 69 G+ F N L++ N E + G+G + T+ PR K D Sbjct: 50 GLNFKNKVGLAAGFDKN-AEHMQIFENLGFGFLELGTVTPKPQSGNKKPRIFRDPKNDAL 108 Query: 70 -GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN-----EQQWEELARLV 123 GF N+ + + +++ K ++I +G+N E + + Sbjct: 109 INSFGFNNVGIY------KFIDNIKKSK----INLVIGINIGKNALTPYEDSINDYIACM 158 Query: 124 QEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC-----RAVKRGSTLPMLAKMT 176 +EA AD + N S P + ++ ++ K ++P+ K++ Sbjct: 159 REAYVYADYLTVNISSPNTKNLRDLHNLSDLSIFIKSLMIEKNKLQKKLKKSVPIFLKLS 218 Query: 177 PNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P+I + + DG+ NT + I + G SG + Sbjct: 219 PDIEKSKIKPIIDLLIANNIDGVIVTNTTIDKSKIS---------KPYQHLPGGVSGAPL 269 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 K + + + ++ + + I +GGI T +DA + + +GA +Q+ TG++ G +V Sbjct: 270 KIKSEQMLSTVKKISKNK-LLIISVGGIMTADDALKRIRMGADLVQIYTGLIYQGPSLVN 328 Query: 295 DMASGLS 301 ++ LS Sbjct: 329 EIRQKLS 335 >UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PV93_9ACTO Length = 394 Score = 175 bits (444), Expect = 3e-42, Method: Composition-based stats. Identities = 69/350 (19%), Positives = 116/350 (33%), Gaps = 67/350 (19%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 L L+ T GV+FP+P L++ N + A G+G V T+ PR Sbjct: 52 LPAGLARTVFGVRFPSPVGLAAGMDKNGIALPAWRA-LGFGFVEVGTVTAHPQPGNEKPR 110 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE----- 113 LV+ + +GF N+ A RL P + +G+++ Sbjct: 111 LFRLVESEAVINRMGFNNLGSAALAD---------RLAAYGPLGYPLGISIGKSKVTPIE 161 Query: 114 ---QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-- 168 + + R + G D N S P D G EL+ + Sbjct: 162 DAVEDYVTSLRRLYRFG-DYFAVNVSSPNTPGLRSLQDAGHLRELLAALHTEAAALAGSG 220 Query: 169 ----------------------------------LPMLAKMTPNIGD--MCEVALAAKRG 192 P+L K+ P++ + + E+ Sbjct: 221 SGSGFGATSGSGAESRSGAESGSGAESGSGSGAVKPILVKIAPDLTEAAIDELLGVCTDA 280 Query: 193 GADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELR 252 G GI A NT + + + G SG+ + I+ + + + Sbjct: 281 GVAGIIATNTTIGREALAPADQA------LAAEAGGLSGRPLTEISAKTVAHIHAETG-G 333 Query: 253 DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 PI G+GGI DAA + GA+ +Q+ TG++ G +V L+ Sbjct: 334 ALPIIGVGGILDPSDAARLIDAGASLVQLYTGLIYRGPGLVRATNRLLAA 383 >UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobiluncus RepID=C2BWU0_9ACTO Length = 348 Score = 174 bits (442), Expect = 4e-42, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 112/309 (36%), Gaps = 42/309 (13%) Query: 11 CGVKFPN--PFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKE 67 G KF P L++ A G+G + TI PR + ++ Sbjct: 64 AGTKFRTYGPLGLAAGMDKEAR-AIAMWDALGFGFMEIGTITPLPQPGNDRPRLWRIPQQ 122 Query: 68 DT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQWE 117 +GF N A A +Y ++++I + +G+N + Sbjct: 123 RALRNAMGFNNEGARAAARRLRRWRA------EYGERIIIGANIGKNKVTPPEKAPADYR 176 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG--STLPMLAKM 175 ++ R++ A D + N S P V +V+ R ++ S LP+ K+ Sbjct: 177 KVTRVLA-ALVDFLVINVSSPNTPGLRDLQAVSSLLPIVKAVQRELESQGLSELPVFVKI 235 Query: 176 TPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D+ VA G G+ A NT + G SG+ Sbjct: 236 APDLVDEDIAAVAQLTMDEGLTGVVATNTT----------------IKHDLGAGGMSGEP 279 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 ++ AL ++ +R H + I G+GGI T EDA L GA ++ + + G Sbjct: 280 LRNRALEVVKLLREHLS-PEKTIIGVGGITTPEDARAMLAAGANLIEGFSAFIYEGPAWP 338 Query: 294 EDMASGLSH 302 + L+H Sbjct: 339 AHLNRELTH 347 >UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomycetaceae RepID=A3ZNL9_9PLAN Length = 372 Score = 174 bits (442), Expect = 4e-42, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 111/324 (34%), Gaps = 22/324 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L G+ FPNP L++ N + G+G +I + PR L Sbjct: 52 LESNVAGLTFPNPVGLAAGWDKNGH-ALRLLDSWGFGFAEIGSISAAASLGNRRPRLFRL 110 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLI----------ASIMGENEQ 114 ++ + + + E L + + P V + AS Sbjct: 111 PQDRAIVVNY----GLPNDGAEVIAQRLAKHRIRRPLGVNLVKTNQGPDAAASSAERIVD 166 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLA 173 + A+ V A + N SCP G D P + + A+ P+ Sbjct: 167 DYVCSAQAVHRH-ASYLTLNLSCPNAAG---GKDFFAQPGSIRQLLTALLPLEIACPLFL 222 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K+ PN D E+ + + + P + +G+ Sbjct: 223 KVAPN-PDPAEIERLLEECEPFAAVRGFLFNLPVGKAASLALTTPRQVWEKMPGAVAGQP 281 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 V ++ R I +M + I G GG+ + DA E + LGA+ +Q+ T ++ G +V Sbjct: 282 VAALSNRCIAEMYQRMPRDRYVIIGGGGVFSAADAYEKMGLGASLIQIYTALVYEGPGVV 341 Query: 294 EDMASGLSHYLADQGFDSLQEMVG 317 + GL LA GF + + VG Sbjct: 342 GRINRGLLQLLAADGFSHVGQAVG 365 >UniRef50_Q7US31 Putative uncharacterized protein n=1 Tax=Rhodopirellula baltica RepID=Q7US31_RHOBA Length = 337 Score = 173 bits (438), Expect = 1e-41, Method: Composition-based stats. Identities = 60/318 (18%), Positives = 116/318 (36%), Gaps = 18/318 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + L+ F G+ +P + +SP+ + + G G +V ++ + S Sbjct: 1 MPSRLNTQFGGLSLRSPVVVGASPLSMNERTRMEMQEAGAGAIVLPSLFEEQVIDWSWNH 60 Query: 62 DHLVKEDTGFIGFKN---MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + I ++ + LA + R D +IAS+ G W + Sbjct: 61 GRQLTPKERMILGQSDRTKHHWVCPDGDSYLALVNR-ASSLQDIPIIASLNGYTAGGWMD 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A ++EAGA IE N + + + R V T+P+ K++ N Sbjct: 120 FAGELEEAGASAIELNV---HHSGAREYGSSAEIEMTILDSIRDVNSAITVPLFVKLSSN 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + +A GA G+ + +I L+ S+ G + Sbjct: 177 FTSLPHIARQLL-SGAQGMVLHGRAPKV-DICLDTLRLASRWRITSADEGV-------DS 227 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 L + Q+ + P++ GG+ + + LL GA VT+ I + G +++ M Sbjct: 228 LDTLMQVHSCC--PAMPLAACGGVGNADHLIKVLLAGADVAMVTSAIYREGASVIQTMLR 285 Query: 299 GLSHYLADQGFDSLQEMV 316 GL ++ S+Q++ Sbjct: 286 GLVSFMEKHDMQSMQDLK 303 >UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MPX3_BDEBA Length = 327 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 103/298 (34%), Gaps = 28/298 (9%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGF 71 G++F NP ++ V E + + G G V TI +P ++ D Sbjct: 41 GLEFANPMGIA-GGVDKNAEHLKEWWALGCGFVEVGTIT---PRAQTPNPGKIMDRDLEL 96 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEELARLVQEA 126 N +E L +Y + I +G+N + LV + Sbjct: 97 QAMWNKMGFPSDGGDEVFHNLASYAPNY--RTPIFVNIGKNRHTPNNDAVADYLTLVDQF 154 Query: 127 G--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--M 182 AD N S P L+ V P+L K++P++G+ + Sbjct: 155 RPFADAFVVNISSPNTAGLRDLQKKENLRALIGPIVDRVSHFEPTPVLVKLSPDMGEEGL 214 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E + G DG NT S P + G SG +K ++ R + Sbjct: 215 AEAVSNCQELGVDGFVLTNTTLSR-----------PAGCHFPAEGGLSGAPLKQLSQRAL 263 Query: 243 QQMRTHPELRD--FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 Q + + +GGI + ED E L +GA +Q+ + ++ +G D+A Sbjct: 264 QIAVQTLGKKREGLLLVSVGGIMSPEDVFERLQMGADLVQIYSALVFHGPGFFHDVAR 321 >UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FBL7_SACEN Length = 338 Score = 167 bits (422), Expect = 8e-40, Method: Composition-based stats. Identities = 67/331 (20%), Positives = 118/331 (35%), Gaps = 50/331 (15%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCA-----------KAYDTGWGGVVFKTIGFFIAN 55 ++ + N SSS +G +G V +T+ Sbjct: 18 AVRLGDIHLRNRLVTSSSLLGYGVANAKLIPYGMSPISQFVPLERFGAVTTRTLTVEPRE 77 Query: 56 E--------VSPRFDHLVKEDTGFI-----GFKNMEQIAEHPLEENLAALRRLKEDYPDK 102 L+K + G+ N L+ L R + Sbjct: 78 GHFTTRDQWPLHELPALLKRYGQALRQVDGGWLNAFGWCNVGLDAYL---RDYYPRTRGQ 134 Query: 103 VLIASIMGENEQQWEELARLVQEA----GADMIECNFSCPQMTSHAMGSDVGQSPELVEK 158 I S+ G + +++ L + +A +E N SC + ++E Sbjct: 135 NTIISVGGFSAEEFVTLIDKINDAVPAGDIAAVEFNVSCHNVNFDFN--------AIIES 186 Query: 159 YCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMP 218 S P++ K++P+ D A A + G + AINTVK + L+ + G P Sbjct: 187 VLAEAVPRSAHPVILKLSPDY-DYLAHARLAAKHGVSALTAINTVKGLR---LDPETGQP 242 Query: 219 IVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAAT 278 ++ K+ G SG+A+KPI LR + ++R PI GGI T++D E+ GA Sbjct: 243 LL--KNRFGGLSGRAIKPIGLRVVAELRDAG--VKLPIIATGGIRTFDDCREYFWAGADA 298 Query: 279 LQVTTGI---MQYGYRIVEDMASGLSHYLAD 306 + + + GY + A+ + + L Sbjct: 299 VSLGSATWFASYPGYALSPLYAARVRNLLRR 329 >UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacteria RepID=PYRD_BUCAI Length = 337 Score = 166 bits (421), Expect = 1e-39, Method: Composition-based stats. Identities = 55/307 (17%), Positives = 116/307 (37%), Gaps = 37/307 (12%) Query: 11 CGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDT 69 G+ F N ++ N E G+G + T+ PR +V + Sbjct: 51 MGLIFDNKLGTAAGIDKNG-EYIDALSKLGFGFIEVGTVTPLPQVGNPKPRMFRIVSMEG 109 Query: 70 --GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEELARL 122 +GF N+ + L R + K +I +G+N+ ++ Sbjct: 110 IINRMGFNNLG----------IDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDDYLIC 159 Query: 123 VQE--AGADMIECNFSCPQMTSHAMGS-----DVGQSPELVEKYCRAVKRGSTLPMLAKM 175 +++ A I N S P T+ ++ K +P+ K+ Sbjct: 160 IEKIYCYAGYIAINISSPNTTNLRNLQYGILFKKLLYKIKKKQKELHKKYLKYVPIAIKI 219 Query: 176 TPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 +P++ ++ +++ R D + A NT +D + G + S G SG Sbjct: 220 SPDLSIKELVDISKQLIRYKIDAVIATNTT-----LDHSSLFG---LKNSSEQGGLSGLP 271 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 ++ + I + + + PI G+GGI + A E + GA +Q+ +G++ +G +++ Sbjct: 272 LQKKSTNTISILSKSLQ-KKIPIIGVGGINSINSAKEKIESGATLIQIYSGLVYHGPKLI 330 Query: 294 EDMASGL 300 + + + + Sbjct: 331 KKIINHI 337 >UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes RepID=B2B417_PODAN Length = 482 Score = 165 bits (419), Expect = 2e-39, Method: Composition-based stats. Identities = 71/355 (20%), Positives = 113/355 (31%), Gaps = 54/355 (15%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 K L++ GV+ NP +S+ + E+ + G G V I PR Sbjct: 124 AKPLAVNVFGVELSNPIGISAG-LDKDAEIPDPLFALGAGVVEVGGITPLPQEGNPKPRV 182 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRR------------------------LKE 97 +V D G I + + +L R LK+ Sbjct: 183 FRVVSTD-GLINRYGLNSKGADAVAAHLRERLRTFARSIGFTEKEMLDGEAGVPVGSLKD 241 Query: 98 DYPDKVLIASIMGENEQQWE----ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQ 151 V IA +E+ E + V AD++ N S P G Sbjct: 242 GRLLCVQIAKNKKTDEKDVEAVKKDYVTCVNRLAPYADVLVVNVSSPNTPGLRDLQATGP 301 Query: 152 SPELVEKYCRAV---KRGSTLPMLAKMTPNIGD---MCEVALAAKRGGADGIAAINTVKS 205 L+ KR ++ K++P+ D M V A G DG+ NT K Sbjct: 302 LTALLSAVVEEAQKTKRKVKPRVMVKVSPDEDDDSQMEGVVQAVWMSGVDGVIVGNTTKK 361 Query: 206 ITNIDLNQ-KIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFP--------- 255 T + ++ GYSG A+ L + + R + Sbjct: 362 RTGLVPKGVRLTSQEQKNIMEDGGYSGPALFNQTLNLVGRYRKMLDSYSLKTEGLGDAFN 421 Query: 256 -----ISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 I GGI ++A + L GA+ V TG++ G + + + + LA Sbjct: 422 KNQKVIFATGGITNGDEALKVLNAGASVAMVYTGMVYGGSGTITRIKNEMREKLA 476 >UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W1V7_9ACTO Length = 341 Score = 165 bits (418), Expect = 2e-39, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 106/301 (35%), Gaps = 41/301 (13%) Query: 19 FCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVK--EDTGFIGFK 75 L++ N E G+G + TI PR L + E +GF Sbjct: 65 LGLAAGMDKN-AEAIHAFSALGFGFIEIGTITPKGQPGNPQPRLWRLPETREIRNQMGFN 123 Query: 76 NMEQIAEHPLEENLAALRRLKE-DYPDKVLIASIMGENE--------QQWEELARLVQEA 126 N H ++ L L +L+ + K+++ S +G+N+ +E A + Sbjct: 124 N------HGVDAALLKLTKLRSTEAGRKIVVGSNIGKNKITSNDEALNDYEICASTLAPL 177 Query: 127 GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS--TLPMLAKMTPNIGD--M 182 +D + N S P V +VE + + + + K+ P++ D + Sbjct: 178 -SDFLVINVSSPNTPGLRDLQTVESLRPIVETTQESANNAAQRDVSVFIKIAPDLADEDI 236 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 VA G G+ A NT + G SG + L + Sbjct: 237 LAVADLVNETGLTGVVAANTT----------------IKHSYESGGISGPRLLNRGLDIV 280 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 +R + D I G+GGI T +DA +L GA L+ T + G + + + Sbjct: 281 ANLRKELDY-DKTIIGVGGISTPDDAISYLDAGADLLEALTAFIYEGPAFPGRINRAVKN 339 Query: 303 Y 303 Y Sbjct: 340 Y 340 >UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G610_PHATR Length = 387 Score = 165 bits (417), Expect = 3e-39, Method: Composition-based stats. Identities = 67/350 (19%), Positives = 134/350 (38%), Gaps = 26/350 (7%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPR 60 + +L+ T G+ +S P +K + G V+ K+ + PR Sbjct: 1 MVVELATTVAGILLKTCVYNASGPRSGTSTALSKVAQSASGAVLAKSATVQKQSGNPQPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAA---LRRLKEDYPDKVLIASIMGENEQQWE 117 H +I N E + + ++ + A +K+ DK S+ G++ Sbjct: 61 TWHHPD----YIASFNSEGLPNNGIDYYIDATTIDDAMKDADDDKPYFVSLSGKSLHDNM 116 Query: 118 ELARLVQEAG----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPM 171 E+ + A IE N +CP + + + + ++ V + + P+ Sbjct: 117 EMLHKIASAPTKNRISAIELNLACPNVIGKPI---IAYDVDQMDSILEQVSQLTDSLPPL 173 Query: 172 LAKMTPNIGDMCEVALAAKRGG-----ADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 K+ P + D AA +A+INT+ + +D+ + P ++ S Sbjct: 174 GVKLPPYL-DFQHFQQAASVLNRHKKLVKYVASINTLGNALAVDVVSEA--PCISSNSGF 230 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 +G SG AV AL ++++R + D + G+GG+ + +D LL GA +QV T Sbjct: 231 AGLSGPAVHYTALANVRKLRELLD-EDIDVVGVGGVRSGKDVFAMLLAGATAVQVGTCHW 289 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVY 336 G + + L + ++G ++++ G R ++ Sbjct: 290 IEGPSCFDRIVDELRVLMEEKGCRRIEDVKGKLKAWSKEGAAKSRQALLS 339 >UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacter pylori 51 RepID=D0IRU1_HELP1 Length = 330 Score = 162 bits (410), Expect = 2e-38, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 101/284 (35%), Gaps = 42/284 (14%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L G+ FPNP L++ N M G+G + T+ PR Sbjct: 48 PKLENEILGLHFPNPLGLAAGFDKN-ISMLRALIAFGFGYLEAGTLTNAAQSGNERPRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 ++E++ +GF N + R P K I +G+N+ E A Sbjct: 107 RHIEEESLQNAMGFNNHGAVLGA---------RSFNRFAPYKTPIGINLGKNKH--IEQA 155 Query: 121 RLVQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 +++ A D N S P + Q+ V + K + P+ Sbjct: 156 HALEDYKAVLNKCLNIGDYYTFNLSSPNTPNLRDL----QNKAFVNELFCMAKEMTHKPL 211 Query: 172 LAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ DM EV +A GA GI A NT I +V + G Sbjct: 212 FLKIAPDLEIDDMLEVVNSAIEAGAHGIIATNTT-----------IDKSLVFAPKEMGGL 260 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLL 273 SGK + + +++ + +S +GGI +DA E + Sbjct: 261 SGKCLTKKSREIFKELAKAFFNKSVLVS-VGGISDAKDAYERIK 303 >UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellular organisms RepID=Q2H299_CHAGB Length = 596 Score = 162 bits (409), Expect = 3e-38, Method: Composition-based stats. Identities = 66/331 (19%), Positives = 106/331 (32%), Gaps = 37/331 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++T G NP +S+ + E+ + G G V A PR + Sbjct: 268 LAVTVFGTTLANPIGISAG-LDKDAEIADPLFALGAGVVEVGGCTPLPQAGNPRPRVFRV 326 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 D G + + + L LR+ GE E + + Sbjct: 327 PAVD-GLVNRYGLNSRGADAMAARLRERLRKFARGLGLSEREVLEAGEEEGGCADGESVA 385 Query: 124 QEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL--P-MLAKM 175 EA AD++ N S P L+ KR P ++ K+ Sbjct: 386 GEAARLAPYADVLVVNVSSPNTPGLRDLQAAEPLARLLGAVVDEAKRAKRKVKPRVMVKV 445 Query: 176 TPNIGDMCEV---ALAAKRGGADGIAAINTVKSITN-----IDLNQKIGMPIVNGKSSIS 227 +P+ D ++ A G DG+ NT K T I L + +V Sbjct: 446 SPDEDDDTQMDGVVQAVWMSGVDGVIVGNTTKRRTGLVKEGIKLTGREQKALV----EDG 501 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFP-------------ISGIGGIETWEDAAEFLLL 274 G+SG A+ L + + R + I GGI + A + L Sbjct: 502 GFSGPAMFDRTLSLVGRYRKMLDSYSLKTSGVNDVFPTPKVIFATGGITNGDQALQVLNA 561 Query: 275 GAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 GA+ V TG++ G + + + LA Sbjct: 562 GASVAMVYTGMVYGGSGTITRIKKEMREKLA 592 >UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36786 Length = 307 Score = 161 bits (407), Expect = 4e-38, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 136/323 (42%), Gaps = 24/323 (7%) Query: 4 KDLSITF----CGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSP 59 +L++T + NP +++ +GN E G ++ + FI + Sbjct: 1 MNLNVTIPSSIGDIHLKNPLMPAAATLGNLIEHARYFDLNELGAMMPNS--MFIDSGSPT 58 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + K + GFI + ++ E+ + L L + LI + ++ Q EEL Sbjct: 59 MAKKICKTNNGFISALSKNNMSIFEFEKEI--LPHLPCET--TPLIIDMKAVDKYQMEEL 114 Query: 120 ARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLAKMTP 177 A +++ IE N +CP + G+ ++P+ ++ V+ + ++AK+ Sbjct: 115 AASIEQMDRIMGIEINLNCP----YGPGTPYWKNPDELKDLVARVRAAAPHKWLIAKVPG 170 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + E+++A + GGAD I + +++ + ID+ G S G A KP+ Sbjct: 171 GDIPVEEISVACQEGGADAITSYSSLNG-SCIDIRTGTYRCGGGGSGGFS---GPAFKPV 226 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 + ++ T D P+ GIGGI ED E+++ GA +QV + + + + Sbjct: 227 GILMCRRAATAV---DIPVIGIGGISCAEDVIEYIMAGAYAVQVGSANLSR-PDFMHRLL 282 Query: 298 SGLSHYLADQGFDSLQEMVGLAN 320 L G SL+E+ G A Sbjct: 283 KDLEALAGQMGISSLEEIRGTAR 305 >UniRef50_C0CVL1 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVL1_9CLOT Length = 291 Score = 161 bits (407), Expect = 5e-38, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 115/307 (37%), Gaps = 20/307 (6%) Query: 20 CLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQ 79 +++ +G+ E + G ++ +I + R L + G+I Sbjct: 1 MPAAAGLGDLIEYGKYYDLSLLGALMPNSIML--ESGSVSRARKLYGAEYGYITSLGSNS 58 Query: 80 IAEHPLEENLAALRRLKEDYP--DKVLIASIMGENEQQWEELARLVQEAG-ADMIECNFS 136 + + ++++ P + LI ++ E+ + LA IE N + Sbjct: 59 LGV------MEYVKKIAVHLPWRESPLILNLKAEDLEGLVRLAGTAAGCREVAGIEINMN 112 Query: 137 CPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA-KMTPNIGDMCEVALAAKRGGAD 195 CP + + + + R V+ + +L K+ + D+ ++A K GAD Sbjct: 113 CPYSMAATDPRQYWRDYGWLREMIRGVREAAGEKLLIIKVPTTMVDVEDIAAIVKECGAD 172 Query: 196 GIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFP 255 G + + ID+ + G S GY G +KP+AL ++ D P Sbjct: 173 GFTSFGALTGCA-IDVRTRE---FRCGNSGSGGYCGPGLKPLALWSCSRVHKAV---DIP 225 Query: 256 ISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEM 315 I GG+ +D E ++ GA +QV + + + + L L + G SL E+ Sbjct: 226 IFSAGGVTNADDVIEHIMAGAWMVQVGSANLTR-PDFMPRLIESLDRRLDELGIRSLDEI 284 Query: 316 VGLANNN 322 G + Sbjct: 285 RGCVKPH 291 >UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus ATCC 17982 RepID=A7BDH3_9ACTO Length = 312 Score = 161 bits (407), Expect = 5e-38, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 106/310 (34%), Gaps = 40/310 (12%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKE 67 T + P+ L++ + + G+ V T+ +PR L++E Sbjct: 26 TLGERRLPSRLGLAAGMDKDAEAVLGMCA-LGYAFVEIGTVTPRPQPGNDAPRLWRLMEE 84 Query: 68 D--TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQWE 117 +GF N E L LR ++ + +G+N +E Sbjct: 85 RGLRNRMGFNNA---GADAAAEKLRELRS--TPAGRATIVGANIGKNKVTSEADAPADYE 139 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST---LPMLAK 174 AR + D + N S P V +++ R + G+ +P+ K Sbjct: 140 YCARTLAH-WVDFVVVNVSSPNTPGLRDLQSVDHLRPILQAARRGCEAGAPDRTMPLFVK 198 Query: 175 MTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D + V K G G+ A NT +N G SG Sbjct: 199 IAPDLADEDIVAVVELTKELGLAGVVATNTT----------------INHNLGEGGVSGA 242 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + P AL + + H + + G GGI + EDA + GA ++ + + G Sbjct: 243 PLLPRALEVVSLVARHLDDDQI-LIGTGGISSPEDALRMISAGADLVEAFSAFIFEGPSW 301 Query: 293 VEDMASGLSH 302 +++ L Sbjct: 302 PGEVSRALQR 311 >UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold_58 n=1 Tax=Sordaria macrospora RepID=D1ZM19_SORMA Length = 753 Score = 160 bits (406), Expect = 6e-38, Method: Composition-based stats. Identities = 64/354 (18%), Positives = 117/354 (33%), Gaps = 59/354 (16%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 LS+ G + NP +S+ + E+ + G G V F PR + Sbjct: 401 LSVNVFGKQLLNPIGISAG-LDKDAEIPDPLFALGAGVVEVGGCTPFPQEGNPKPRVFRI 459 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKEDY----------------------PD 101 D G I + + L LR+ P Sbjct: 460 PTVD-GLINRYGLNSRGADAMATRLRERLRKFARSVGLSENQVLNEEGTDDIPPGSLHPG 518 Query: 102 KVLIASIMGENEQQWEELARLVQEA---------GADMIECNFSCPQMTSHAMGSDVGQS 152 ++L I + +++ ++++ AD++ N S P Sbjct: 519 RLLCVQIAKNKKTDEKDVNSVIRDYVYCVDKLAPYADVLVVNVSSPNTPGLRDLQATEPL 578 Query: 153 PELVEKYCRAVK--RGSTLP-MLAKMTPNIGD---MCEVALAAKRGGADGIAAINTVKSI 206 +L+ A + + P ++ K++P+ D M V A G DG+ NT K Sbjct: 579 TKLLSAVVDAAQATKRKNKPRVMVKVSPDEDDNTQMEGVVEAVWNSGVDGVIVGNTTKRR 638 Query: 207 TNIDLNQKIGMPIVNGKSSI----SGYSGKAVKPIALRFIQQMRTHPELRDFP------- 255 T I G+ ++ + + G+SG A+ + + + R + Sbjct: 639 TGI---IPQGVKLIGDEPEVLHEEGGFSGPALFDRTVSLVGRYRKMLDGYALKNEADKSA 695 Query: 256 ----ISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 + GGI E A + L GA+ V TG++ G + + + + LA Sbjct: 696 AQKVLFATGGITNGEQALKVLNAGASVAMVYTGMVYGGSGTITRIKTEMKEKLA 749 >UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NF21_KYTSD Length = 385 Score = 160 bits (404), Expect = 1e-37, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 111/306 (36%), Gaps = 33/306 (10%) Query: 11 CGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDT 69 GV F + L++ + + G G V T+ PR L Sbjct: 93 AGVAFGHRVGLAAGVDKDGTALLTW-QALGLGHVELGTVTPRPQHGNPRPRVHRL----R 147 Query: 70 GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGA- 128 N +E + LR +++ + SI G+N+ LAR +++ A Sbjct: 148 ASRAVLNAMGFPNAGVEAAVHRLRVARDEGLTIPVGLSI-GKNKD--TPLARALEDYAAC 204 Query: 129 --------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS------TLPMLAK 174 D + N S P +D L+ A + + +P+L K Sbjct: 205 VRVAAGLPDYLAVNISSPNTPGLRGLADPEPLRALLAGVVAAERERADAAGTPPVPVLCK 264 Query: 175 MTPNIGDMCEVAL--AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D A A+ G GI A NT + + + G G SG Sbjct: 265 VAPDMDDAALHAAVGIAQEEGVAGIIATNTTLRRDGLTAEDRAWV----GPERPGGVSGA 320 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + A ++ +R D P+ G+GG+ T +D E + GA +QV TG + G + Sbjct: 321 PLTDRAREVVRLVRAGC---DLPVVGVGGVMTPQDGVELVRAGADLVQVYTGFIYAGPAL 377 Query: 293 VEDMAS 298 V +A+ Sbjct: 378 VAGIAA 383 >UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=1 Tax=Ostreococcus tauri RepID=Q00YC9_OSTTA Length = 369 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 51/228 (22%), Positives = 82/228 (35%), Gaps = 21/228 (9%) Query: 94 RLKEDYPDKVLIASIM-------GENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMG 146 R +ED P VL ++ + + E G D I N S P Sbjct: 8 RAREDVPAGVLGVNLGKNKTTPEANAADDYVLGVDNIGEYG-DYIVVNVSSPNTPGLRNL 66 Query: 147 SDVGQSPELVEKYCRAVKRG---STLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAIN 201 L+ K A R + P+L K+ P++ D + +VA K DG+ N Sbjct: 67 QGRKHLSGLLRKVLSARDRNPATAKKPVLVKIAPDLTDAEIKDVASVVKSEKVDGVIVSN 126 Query: 202 TVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGG 261 T + + G SGK + + R + ++ + P+ G GG Sbjct: 127 TTVARP-------EEIKAHKHGDEAGGLSGKPLMESSTRVLHELYRLTGGK-IPLVGCGG 178 Query: 262 IETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 + + EDA + GA +Q+ T G ++ + L LA GF Sbjct: 179 VASGEDAYAKIRAGATLVQLYTAFAFGGPPLILKIKRELEECLARDGF 226 >UniRef50_A1B7Q9 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Paracoccus denitrificans PD1222 RepID=A1B7Q9_PARDP Length = 359 Score = 151 bits (382), Expect = 4e-35, Method: Composition-based stats. Identities = 69/343 (20%), Positives = 122/343 (35%), Gaps = 23/343 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS+ + NP +S A G G VV K+ A + Sbjct: 1 MTDLSVQVGRTRLKNPVIAASGEHLIDDAGILSAIAAGAGAVVMKSSNDSAAAQRQLLQA 60 Query: 63 HLVKEDT------------GFIGFKNMEQIAEHPLEENLAALRR--LKEDYPDKVLIASI 108 D + + L RR D VL+AS+ Sbjct: 61 EYAALDACWNRVDWGPGAPREATLLTRSGLTPLGFDAWLDQARRMDAAARKADCVLVASV 120 Query: 109 MGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQ-SPELVEKYCRAVKRGS 167 + + AR V++AG + E N P + A G+ + SP V + V Sbjct: 121 VMAGIEDAVRRARAVEDAGLRVFEFNIGTPYASQAAKGAVSTELSPARVAELVGQVTSAV 180 Query: 168 TLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 ++P+ K++ + E+ AA GAD + + + P++ I Sbjct: 181 SIPVWVKLSGQSERVPELVAAATGAGADSAVIAGRALGLVP---DLETMQPMLGTSCGIG 237 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 GY P+ ++ R + GI G + D A +L GA+ + +++ +M Sbjct: 238 GYWN---LPLTCHWLAMTRARLGAGR-ALIGINGACSGRDVARMMLAGASAVGLSSAVML 293 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 G+ ++ D + L Y A +G S +++VG A + ++ Sbjct: 294 RGWDVIRDAVADLDAYCAQKG-ASARDLVGRAADARRSFAEMP 335 >UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaproteobacteria RepID=PYRD_WIGBR Length = 337 Score = 145 bits (367), Expect = 2e-33, Method: Composition-based stats. Identities = 59/305 (19%), Positives = 115/305 (37%), Gaps = 36/305 (11%) Query: 11 CGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLV--KE 67 G+ F N L++ N + D G+G + T+ E PR Sbjct: 50 MGLNFKNILGLAAGLDKNG-DYIKLFSDIGFGFIELGTVTLKPQHGEKKPRLFCFPNVYG 108 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR---LVQ 124 +GF N ENL + +K + K ++ +G+N+ E A+ L+ Sbjct: 109 IINRMGFNNNGI-------ENL--IENIKNEKNVKSILGINIGKNKDTLIEKAKDDYLIC 159 Query: 125 EAGA----DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL-----PMLAKM 175 A D I N S P +L++ + + + P+L K+ Sbjct: 160 INKAYYYSDYISINISSPNTKDLRKLQFGELFSDLLKSIKEEQNKLNKIYNKYVPILIKI 219 Query: 176 TPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 +P+I ++ +++ DG+ A NT + I G SG Sbjct: 220 SPDINNSEIIQISDCLLSYNIDGVIATNTTVNKDII--------MRCCNNCEKGGLSGAP 271 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 + + R I+++ + + I G I + + A E + GA+ +Q+ +G++ +G +I+ Sbjct: 272 LNENSTRIIKKLSKELKGKIPIIGSGG-IISVKSAKEKIKAGASLIQIYSGLVFFGLKII 330 Query: 294 EDMAS 298 + + Sbjct: 331 KKLIK 335 >UniRef50_UPI00019039D0 dihydropyrimidine dehydrogenase n=2 Tax=Rhizobium etli RepID=UPI00019039D0 Length = 179 Score = 143 bits (360), Expect = 1e-32, Method: Composition-based stats. Identities = 51/130 (39%), Positives = 79/130 (60%), Gaps = 2/130 (1%) Query: 272 LLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331 L+LGA +QV T M YG++IV++M SGLS ++ ++G +L ++ G A N+ + L+ Sbjct: 17 LVLGAGNVQVCTAAMTYGFKIVDEMISGLSDWMDEKGHRTLDDITGRAVPNVTDWQYLNL 76 Query: 332 SYIVYPRINLDKCVGCGRCYISCYDGGHQAME-WSEKTRTPHCNTEKCVGCLLCGHVCPV 390 +Y+ +I+ D C+ CGRC+I+C D HQA+ R E+CVGC LC VCPV Sbjct: 77 NYVAKAKIDQDACIKCGRCHIACEDTSHQAITNVVNGLRHFEVIDEECVGCNLCVSVCPV 136 Query: 391 -GCIELGEVK 399 CI + ++ Sbjct: 137 ENCITMEQLP 146 >UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJ75_FIBSS Length = 391 Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 118/344 (34%), Gaps = 39/344 (11%) Query: 4 KDLS------ITFCG----VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI 53 DLS +TF + F P L++ + + G+GG+ T + Sbjct: 54 PDLSKTLNRVVTFADGSNPLHFGCPIMLAAG-ANKTAKRICDFANMGFGGISVGTATRHV 112 Query: 54 ANEVSPRFD-HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN 112 + R ++ D + + + V I+ + E Sbjct: 113 REGNTHRPRIGFIENDRAIHNSMGLNNDGVDAVTRRVDTQITAAHRVQMCVGIS--VAET 170 Query: 113 E---QQWEELARLVQEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV- 163 + E+L +V+ AD +E N SCP + + D+ LV K A+ Sbjct: 171 PGLTDENEKLQDIVESFSIAYRVADYVEINLSCPNTGENRLDLDMT----LVNKIFTAIT 226 Query: 164 ----KRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLN---QK 214 K+ + AK++P++ + + + G +G+ NT + DL + Sbjct: 227 DYRNKQPVRKAIYAKLSPDMPENHTATIMDMLVKVGVNGVVMGNTYPTKKVTDLPVHVKY 286 Query: 215 IGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLL 274 + + + G SG+ + +R ++ +R H + GGI+ + + L Sbjct: 287 DDLTPLRADNDRGGMSGRPLYENTVRNVKFIREHY--PQMSVIACGGIDHGYKIYDLIKL 344 Query: 275 GAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G +Q + + M L L+ GF SL + Sbjct: 345 GVDAVQCYSVVAFRWMA-AHAMRKELEEALSKDGFKSLADYDAK 387 >UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroides RepID=C6IFT5_9BACE Length = 332 Score = 140 bits (354), Expect = 7e-32, Method: Composition-based stats. Identities = 56/305 (18%), Positives = 118/305 (38%), Gaps = 33/305 (10%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFDHLVKE 67 ++ ++F N LS+ N E + D G+G + T+ + SPR LV++ Sbjct: 50 SYGSLRFKNRIGLSAGFDKN-AETFDELADFGFGFLEVGTVTPDYQPGNPSPRIFRLVED 108 Query: 68 DT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 ++ GF N ++ L +R+ ++ + + + + ++ + + Sbjct: 109 ESLISRTGFNNC------GVDVALEHIRKYRKHSYRLGVNINKNPLSAGE--QIIKDFEL 160 Query: 126 A------GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 D N + E + + +AV + + + K+ +I Sbjct: 161 VFTRLYESVDYFTLN------WGSIDKESFAKVLENLTTFRQAVNKRCS--IFIKLPADI 212 Query: 180 GD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + V A + +G A T ++ +L+ + K G SG+ + Sbjct: 213 DEKALDLVISLAYKYSIEGFIA--TGPTMDRSELHHTKTKQL--EKIGNGGVSGRGIGKK 268 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 + + ++ + H + F I G GGI T EDAA+ + GA +Q+ + + G +V + Sbjct: 269 SQKVVRYLSGHTD-HHFLIIGAGGIMTAEDAADMISQGADMIQIYSAFIYSGPSVVHKIG 327 Query: 298 SGLSH 302 L H Sbjct: 328 KKLKH 332 >UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=PYRD_DICDI Length = 370 Score = 138 bits (348), Expect = 3e-31, Method: Composition-based stats. Identities = 68/321 (21%), Positives = 118/321 (36%), Gaps = 44/321 (13%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA---NEVSPRFDHL 64 I F G K +P + + P+ N + A + G+ +KTI + + L Sbjct: 44 IDFLGQKLASPIGVPAGPLLNS-QWVKFALEAGFDLPTYKTIRSHEHFGHPVPNVMYLDL 102 Query: 65 VKEDTGF---------------------IGFKNMEQIAEHPLEENLAALRRLKEDY-PDK 102 ED F + N + E + + Sbjct: 103 ESEDKQFTKSDSGSTLHATQTIPTTMDQLAITNSFGMPSMGKEYLYKDIALAHSYLGSGQ 162 Query: 103 VLIASIMGENE------QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELV 156 +I SI G Q + + R+ +AGA M+E N+SCP + + + +P+ V Sbjct: 163 SMIVSITGTASSAHDFLQDFVDTVRIACDAGAKMVEVNYSCPNVVTGE--GQIYHNPDAV 220 Query: 157 EKYCRAVKRG---STLPMLAKMT--PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDL 211 + + + +P++ K+ ++ M + A+R G IA INT+ S+ D Sbjct: 221 YEISSTLVKELSSKNIPLIIKVGVMDDLEKMERLFQQAERAGVAAIAGINTL-SMKVTD- 278 Query: 212 NQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT--HPELRDFPISGIGGIETWEDAA 269 + G P + SG G ++ AL ++ + + + G GGI E Sbjct: 279 -KITGEPSLGASRLTSGVCGAPIRSAALDWVSTASSIIKKQNSKLKLLGCGGIVKPEHFD 337 Query: 270 EFLLLGAATLQVTTGIMQYGY 290 +FL GA TG+M Y Sbjct: 338 DFLNSGADIAMSATGLMWDPY 358 >UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bacteroides RepID=B5CXJ8_9BACE Length = 349 Score = 137 bits (346), Expect = 5e-31, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 107/302 (35%), Gaps = 41/302 (13%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVKEDT-- 69 + F N LS+ + D G+G + T+ +A PR L ++ Sbjct: 75 LTFANRVGLSAGFDKE-ANCFDELSDLGFGFLEVGTVTPEKVAGNPFPRIFRLPEDHALV 133 Query: 70 GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE---- 125 GF N + E L L+R +E +L +I E + + Sbjct: 134 SRTGFNNPGK------EVVLKNLQRKREG--KYILGVNINTNTPTDAERAVTDITDLYET 185 Query: 126 --AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV---KRGSTLPMLAKMTPNIG 180 A AD N+ +PE++ A+ K+ P+ K+ ++ Sbjct: 186 FSAYADYYTINWGS-------------MTPEILADVLTALESYKQRFHRPVFLKLPADVP 232 Query: 181 D--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + V AK DG A + + + + + + + G SG V + Sbjct: 233 AEKLDTVIEFAKVHHIDGFIATGPTQDRSLLIHSAQTEV----ERVGAGGISGLPVIHKS 288 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 L ++ + H +D + G GG+ T +A GA +QV + + G +V+ +A Sbjct: 289 LEVMKHLSAHAP-KDMLLIGAGGVMTPFEAKAMRNAGAHLVQVYSAFIYEGPGVVKRIAE 347 Query: 299 GL 300 + Sbjct: 348 KI 349 >UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Rickettsiella grylli RepID=A8PKY4_9COXI Length = 355 Score = 134 bits (337), Expect = 6e-30, Method: Composition-based stats. Identities = 78/315 (24%), Positives = 131/315 (41%), Gaps = 40/315 (12%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-----FFIANEVSP--- 59 ++F G + +++ V + A G+ + +KTI + P Sbjct: 40 VSFLGYSLASKIGVAACAVTTG-KGIALLAQLGFDILTYKTIRCKAYPTHPLPNIVPIQV 98 Query: 60 --RFDH----LVKEDTGFIGFKNMEQIAEHPLEENLAA------LRRLKEDYPD-KVLIA 106 +FD+ V I N I+ L + K D +VLI Sbjct: 99 DKQFDYSDLDEVVSTKKIIEINNKIAISNSFGNGCLEPRVVMQDIAFSKSALVDGQVLIV 158 Query: 107 SIMGENE------QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKY- 159 S+ GE Q + A + +EAGAD+IE NFSCP + + ++ + V + Sbjct: 159 SVYGEGHSLSAMSQDFMTAALMAKEAGADIIELNFSCPNLMK--SDEPLYRNMDCVSQIT 216 Query: 160 CRAVKRGSTLPMLAKMT--PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGM 217 R VK +P+L K+ ++ ++A R G GI+AIN++ S+ ++ N + Sbjct: 217 TRVVKCVGDIPLLLKIGFIHEHEFPLKLLISAARAGVRGISAINSI-SMRVLNQNHRPAF 275 Query: 218 PIVNGKSSISGYSGKAVKPIALRFIQQMR--THPELRDFPISGIGGIETWEDAAEFLLLG 275 GK SG SG ++ +AL+ ++++ E + I G+GGI E EF G Sbjct: 276 ----GKRIYSGISGYPIRRLALQSVKKLTQINQKEKLNLTIVGMGGITVAEHFDEFFDRG 331 Query: 276 AATLQVTTGIMQYGY 290 A + TG+M Y Sbjct: 332 ADAVLSATGVMWNPY 346 >UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rhodopseudomonas palustris HaA2 RepID=Q2IVE7_RHOP2 Length = 348 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 51/301 (16%), Positives = 101/301 (33%), Gaps = 26/301 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L F GV+ PNP L++ E+ A G+G V +I PR Sbjct: 48 PRLVTRFAGVELPNPVGLAAGFDK-DAELIAALSCLGFGFVCVGSIMPEPRVGNPFPRLV 106 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 G + + LRRL +IA+I G + A + Sbjct: 107 R----RRGTESIADSMGVPSKGRAYATERLRRLGPRA--VPVIANIGGFSADTIA--AGV 158 Query: 123 VQEAG-ADMIECNFSCPQM-TSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ A D++E + CP + + ++G ++ + G ++ ++ + Sbjct: 159 IEVAPHVDLVELSLMCPNVLADGEVFDEIGMLRGVLARL-----DGRAGSIVVRVPNDTT 213 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + + I + ++I P + + G+ + AL Sbjct: 214 RLHDRFAELIE------VCIAAGVGGIKVGGGRRIAEPGLG--TGAGTLHGREIFDTALM 265 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 +++ I G GGI + D GA+ + + + + G+ I D+ L Sbjct: 266 NVERAAGFAR-GRLAIKGNGGISSAADVLAMRRAGASCVDLYSAFIYQGWTIARDINRAL 324 Query: 301 S 301 + Sbjct: 325 A 325 >UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospirillum RepID=A3ETM0_9BACT Length = 368 Score = 129 bits (323), Expect = 3e-28, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 122/324 (37%), Gaps = 42/324 (12%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTI-GFFIANEVSP- 59 + D I F G K + + + P+ N + G+ + +KT+ F + P Sbjct: 31 IQTDTRIDFMGEKVSSRLGIPAGPLLNSR-WISFYGQMGFDILTYKTVRSHFHPSYPDPN 89 Query: 60 -------RFDHLVKEDTGFIGF--------------KNMEQIAEHPLEENLAALRRLKED 98 + L IG + ++HP L Sbjct: 90 CMYVPFHKSFDLEDLQHPLIGTMAYNPVSLTDITITNSFGMPSQHPDIWMRDVGEALSSL 149 Query: 99 YPDKVLIASIMGENEQQ------WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQS 152 +VL+ S++G ++ + A L +E GA ++E NFSCP + + Q+ Sbjct: 150 SSGQVLVLSLVGTQREERDLAQDFVYTAHLAKETGAKILEVNFSCPNVKGKE--GQLYQN 207 Query: 153 PELVEKYCRAVKR--GSTLPMLAKMT-PNIGDMCEVALAAKRGGADGIAAINTVKSITNI 209 P+ + + +++ G ++ K+ + + + + A D I+AINTV Sbjct: 208 PDASGEILKRIRKELGRDFHLIMKIGFSDNPEHLDRLVEATSPYLDAISAINTVTGT--- 264 Query: 210 DLNQKIGMPIVNGKS-SISGYSGKAVKPIALRFIQQMRT--HPELRDFPISGIGGIETWE 266 + G P + G SG G +K ++L+ I+ ++ + G+GG T E Sbjct: 265 -IINPEGKPALPGPGRERSGLCGSGIKNLSLKTIRGLKQALRRRAPQLSLIGVGGFNTVE 323 Query: 267 DAAEFLLLGAATLQVTTGIMQYGY 290 D +F GA + TG M + Sbjct: 324 DYPDFREAGADIVMSATGAMWDPF 347 >UniRef50_A8L1Y0 Dihydroorotate oxidase n=4 Tax=Frankia RepID=A8L1Y0_FRASN Length = 321 Score = 128 bits (321), Expect = 4e-28, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 121/321 (37%), Gaps = 36/321 (11%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKE 67 +T GV +P ++ E VV +I + Sbjct: 4 VTLAGVALEHPIMNAAGTCK-TVEDVTALARGAVAAVVVGSITRDARTGNG--GEVYWSG 60 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 + + + E L A+ + Y K L+ S+ G +++ LAR+ + G Sbjct: 61 GSYSLNALGLPNRGIGYYAEQLPAMADIAHGY-GKPLVVSVAGFAAEEYATLARVAADTG 119 Query: 128 ADMIECNFSCPQMTSHAMGS-----DVGQSPELVEKYCRAVKRGSTLP-------MLAKM 175 AD+IE N CP + D+GQ+ + + A+ G P K+ Sbjct: 120 ADLIELNLGCPNVWDGGSQKRIACFDLGQTDAICAQVEAALAGGRAGPGHRRAPAYGVKV 179 Query: 176 TPNIGDMCEVALAAKRGG----ADG----IAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 +P D +A A G ADG + A+NT + +D ++ + + +++ Sbjct: 180 SP-FSDPEALADLAALLGRRSEADGGPRFVTAVNTFPNALVLDDRRRPVLDV-----ALA 233 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG A+KP+ L ++Q+R + + G + + A ++L GA +Q T Sbjct: 234 GLSGAALKPVGLGQVRQLRALLPEQVDVVGVGGVLGGRDVA-DYLAAGARAVQGATAFWN 292 Query: 288 YG--YRIVEDMASGLSHYLAD 306 G + D+ LS ++ Sbjct: 293 RGEDPTVFGDI---LSDWIDA 310 >UniRef50_D2S9D7 Dihydroorotate oxidase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S9D7_9ACTO Length = 385 Score = 128 bits (321), Expect = 4e-28, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 127/328 (38%), Gaps = 47/328 (14%) Query: 18 PFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI---------------ANEVSPRFD 62 P + + + E G+ + +KT+ A + P Sbjct: 60 PIGVPACVLNGGEEWVRHFARNGYSVLTYKTVRSRAHEPNAQPNWVFAARQAQSLPPGAA 119 Query: 63 HLVKED--------TGFIGFKNMEQIAEHPLEENLAALRR-LKEDYPDKVLIASIMGEN- 112 V D + + N + E+ +A L R L D++L+ S+MGE Sbjct: 120 AEVTADPWDWVAPGSPDVSTVNSFGVPSLAPEQWMADLERSLAAVDDDQLLLVSVMGEGD 179 Query: 113 ----EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGS--------DVGQSPELVEKYC 160 + ARL QEAGA ++E N SCP S + + D G + +VE Sbjct: 180 GTGLVDDFAATARLAQEAGASVVELNLSCPNTLSTSTAAGVKPPLCLDAGATVAVVEGVR 239 Query: 161 RAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 RA+ + ++AK++ G E + DGIA INT++S + + G P Sbjct: 240 RALDDRTG--LVAKLSWLDGARLEALVPRLAPLVDGIAGINTLQSR----VRRSDGEPTF 293 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTH--PELRDFPISGIGGIETWEDAAEFLLLGAAT 278 G+ ++G SG AV+ AL F +++ R F + +GG+ A LGA Sbjct: 294 PGR-ELAGLSGAAVRDSALDFTRRLVALRDAGGRHFDVLAMGGVTDPASFAALFALGADA 352 Query: 279 LQVTTGIMQYGYRIVEDMASGLSHYLAD 306 +Q +G + + D + L L Sbjct: 353 VQSASGAFAAPF-LARDCVAALGETLPR 379 >UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=A2QCB1_ASPNC Length = 544 Score = 127 bits (320), Expect = 5e-28, Method: Composition-based stats. Identities = 58/376 (15%), Positives = 103/376 (27%), Gaps = 83/376 (22%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFK-TIGFFIANEVSPRFDHL 64 L G NP + S + ++ ++ G V T PR L Sbjct: 171 LLTEVFGYTLSNPIGI-SGGLDKHADIPDPLFELGPAIVEVGGTTPLPQDGNPRPRVFRL 229 Query: 65 VKEDTGFIGFKNMEQ------------------IAEHPLEENLAALRRLKEDYPDKV--- 103 + I + A E LA R L + Sbjct: 230 PSQ-KAMINRYGLNSKGADHMAAVLEQRVRDYAYAHGFGEHELAEQRVLNGEAGVPPGSL 288 Query: 104 ----LIASIMGENE-----------QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSD 148 L+A + +N+ + + + + AD++ N S P Sbjct: 289 REGKLLAVQVAKNKLTPDNDIEAIKRDYVYCVDRLAKY-ADILVVNVSSPNTPGLRDLQA 347 Query: 149 VGQSPELVEKYCRAVKR--GSTLP-MLAKMTPNIGDMCE---VALAAKRGGADGIAAINT 202 +++ A K T P ++ K++P+ + + A G DG+ NT Sbjct: 348 TAPLTAILKAVVGAAKSIDRKTKPFVMVKVSPDEDADEQVSGICDAVWGSGVDGVIVGNT 407 Query: 203 VKSITNIDLNQKIGMPIVNGK--SSISGYSGKAVKPIALRFIQQMR-------------- 246 L + +P GYSG + + + + R Sbjct: 408 TNRRPEP-LPKGFTLPSKEQDVLKETGGYSGPQLFDRTVALVARYRSLLDASAPAAAAVP 466 Query: 247 -----THPELRDFP---------------ISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 P++ + P I GG+ A + L GA+ + T I Sbjct: 467 KALEAAEPDVENVPPTVSEAVEGLPARKVIFASGGVTNGAQARKVLDAGASVAMMYTAIT 526 Query: 287 QYGYRIVEDMASGLSH 302 G V + + Sbjct: 527 YGGLGTVTRVKEEMKE 542 >UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacteria RepID=D2Q7Y3_9BIFI Length = 375 Score = 124 bits (312), Expect = 5e-27, Method: Composition-based stats. Identities = 73/331 (22%), Positives = 123/331 (37%), Gaps = 47/331 (14%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI--------------- 53 F G PF + + P+ N A+ G+ V+KT+ Sbjct: 53 DFLGFHVNLPFGIPAGPLLNER-FTTAAFRMGFDLAVYKTVRSRAWGCNAFPNVLAVHPK 111 Query: 54 --ANEVSPRFDHLVKEDTG------FIGFKNMEQIAEHPLEENLAALRRLKEDY-PDKVL 104 + P L + I N + +E +++ E ++L Sbjct: 112 NADGSLIPGSAELDEGVLADTRYELPISISNSFGVPSRDPDEWQPDMKKAIEAAGSGQLL 171 Query: 105 IAS-----IMGENEQQW----EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPEL 155 + S + G ++ + ARLV E GA ++E N SCP + + + P L Sbjct: 172 VPSFQGSRVDGMDQDDYIADHVTTARLVCETGAGLMEMNTSCPNEGHNRL---LCHDPHL 228 Query: 156 VEKYCRAVKRGS-TLPMLAKMT--PNIGDMCEVAL-AAKRGGADGIAAINTVKSITNIDL 211 V + AVK P++ K+ PN D+ + A G G + INT+ + +D Sbjct: 229 VGRITEAVKNEIGDRPLVVKLAYIPNDADLEIMVKETAAHGTVQGFSTINTISAKL-VDA 287 Query: 212 NQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE--LRDFPISGIGGIETWEDAA 269 + +P SG G A++ L + ++ E DF I G+GG+ ED Sbjct: 288 HGNQALP--GAGRDRSGVCGNAIRGAGLDMVGRLHAIREKLGLDFTIVGVGGVVRPEDYR 345 Query: 270 EFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + GA + TG M + D+AS + Sbjct: 346 AYREAGANAVMSATGAMWN-ANLARDIASSI 375 >UniRef50_UPI000187EFAF hypothetical protein MPER_16226 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187EFAF Length = 181 Score = 122 bits (307), Expect = 2e-26, Method: Composition-based stats. Identities = 38/161 (23%), Positives = 66/161 (40%), Gaps = 11/161 (6%) Query: 163 VKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 V R ++ K+ P++ D + ++A ++ DG+ NT G+ Sbjct: 2 VPRHPKPRIVLKIAPDLDDTQIEDMADVIRKSSIDGVIVSNTTTQRPK-------GLVSP 54 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQ 280 K G SG +K + L ++ +R+H D PI G GGI + DA ++ GA +Q Sbjct: 55 ENKGQTGGLSGPPLKSLTLNTLRILRSHLPA-DIPIIGCGGISSGTDALDYARAGATMVQ 113 Query: 281 VTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 V T G + + + L +G + +V A Sbjct: 114 VYTSFGYDGAGMCRRVKDEIVEALGSEGV-NWNNLVNRAVQ 153 >UniRef50_C1SIN0 Putative uncharacterized protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SIN0_9BACT Length = 175 Score = 122 bits (306), Expect = 2e-26, Method: Composition-based stats. Identities = 40/181 (22%), Positives = 72/181 (39%), Gaps = 22/181 (12%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI--------A 54 D+S+ + G++ +P SS + + +A D G G VV K++ Sbjct: 1 MADISVDYMGLQLTSPVIAGSSTLTKDMDNLRRAEDAGAGAVVLKSLFEEEIRLEAGTVE 60 Query: 55 NEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQ 114 P + D + + E L ++R + +IASI E + Sbjct: 61 ETYHPEAYDYMTADAAMV----------YGSGEYLEYVKRAADKVTI-PVIASINCEGTK 109 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 W + A ++EAGAD IE N + + G + + E + + VK+ ++P+ K Sbjct: 110 WWAKFAGDIEEAGADAIELNIAFMPFEADITGQE---TEERYLEVVKEVKKTVSIPVGVK 166 Query: 175 M 175 M Sbjct: 167 M 167 >UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 Tax=Leotiomyceta RepID=B2WMQ8_PYRTR Length = 455 Score = 122 bits (306), Expect = 3e-26, Method: Composition-based stats. Identities = 60/311 (19%), Positives = 101/311 (32%), Gaps = 50/311 (16%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 DL++ G NP S+ E+ ++ G G V + PR Sbjct: 23 DLAVEVFGHTLNNPIGTSAGIDK-GAEIPTPLFELGAGVVEVGAVTLLPQEGNPKPRVFR 81 Query: 64 LVKEDT--GFIGFK--NMEQIAEH------------PLEENLAALRRLKEDYPDKVL--- 104 L ++ GF E +A L + A RR+ + Sbjct: 82 LPSQNALINRYGFNSEGAELVASRLRQRVREFAYRIGLGLDEDAERRVLDGEAGVPPGSL 141 Query: 105 ---------IASIMGENEQQWE----ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDV 149 +A +E + + A V G AD++ N S P +V Sbjct: 142 LKGRLMAVQVAKNKTTSENDIDAVVRDYATAVGYVGKYADILVVNVSSPNTPGLRTLQNV 201 Query: 150 GQSPELVEKYCRAVKR--GSTLP-MLAKMTPNIGDMCEVA---LAAKRGGADGIAAINTV 203 L+ AVK+ T P ++ K++P+ ++A A G DG+ NT Sbjct: 202 EPLTRLLSGVVSAVKKIDRKTKPAVMVKVSPDEDSESQIAGICEAVWDSGVDGVIVGNTT 261 Query: 204 KSITNIDLNQKIGMPIVNGK--SSISGYSGKAVKPIALRFIQQMRTHPELRDFPIS---- 257 K + L + +P K GYSG + L + + R + +S Sbjct: 262 KKRPDP-LPKGYLLPESEAKLLLEQGGYSGPQMFERTLALVSKYRKALDEGPKHVSPQDS 320 Query: 258 -GIGGIETWED 267 + G T ++ Sbjct: 321 KSVTGQSTGDE 331 Score = 60.4 bits (145), Expect = 1e-07, Method: Composition-based stats. Identities = 25/107 (23%), Positives = 43/107 (40%), Gaps = 4/107 (3%) Query: 196 GIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFP 255 +++ + K+ +DL+Q P+ + I S A K I L+ + P+ Sbjct: 342 PLSSSQSSKTKATLDLDQPSPKPLSSNIDDI---SESAPK-ITLQATPKAAPAPDAPRKV 397 Query: 256 ISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 I GGI A E L GA+ QV T ++ G + + + Sbjct: 398 IFATGGITNGRQAREILDAGASVAQVYTAMIYGGAGTISRIKQEMRD 444 >UniRef50_UPI0001B4E622 dihydroorotate dehydrogenase n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4E622 Length = 230 Score = 121 bits (303), Expect = 5e-26, Method: Composition-based stats. Identities = 41/209 (19%), Positives = 81/209 (38%), Gaps = 8/209 (3%) Query: 130 MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAA 189 +E N P + + + V +Y R V P++ K+ D+ +A AA Sbjct: 26 AVEINIGAPHGREAGAVRQLTE-ADGVARYVRTVSAAMDRPLIVKLPGQASDILGMARAA 84 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 GAD + I + N + P + ++ G + PI+L ++ + R Sbjct: 85 VDNGADAVTLIGRLGGFVP---NLETWEPELGSWGAVGG---PWMLPISLYWLSKCRRDL 138 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 P+ G G D A FLL GA +++ + ++ G + ++ L YL +G Sbjct: 139 GDGT-PLIGTNGARDGLDVARFLLSGAHAVELASLLLLRGAPALTEVLVQLGAYLDARGI 197 Query: 310 DSLQEMVGLANNNIVPAEDLDRSYIVYPR 338 L +++G + + +++ Sbjct: 198 GRLDDIIGASADRARTYAEIEPLTPPRRP 226 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria ... 417 e-115 UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14... 402 e-111 UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Ta... 342 2e-92 UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria... 331 4e-89 UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydr... 313 1e-83 UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 ... 312 2e-83 UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 ... 293 7e-78 UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genom... 291 3e-77 UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 ... 289 2e-76 UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 ... 288 4e-76 UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 ... 279 1e-73 UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 ... 275 3e-72 UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Ta... 274 5e-72 UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 ... 272 2e-71 UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehyd... 271 4e-71 UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga ... 268 2e-70 UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 ... 267 4e-70 UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10... 265 2e-69 UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 264 4e-69 UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 ... 262 2e-68 UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerot... 257 4e-67 UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax... 257 5e-67 UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1... 256 1e-66 UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39... 252 1e-65 UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria R... 252 2e-65 UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular o... 251 3e-65 UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-clust... 250 6e-65 UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14... 249 2e-64 UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organ... 246 1e-63 UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 245 2e-63 UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 ... 244 4e-63 UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit ... 243 1e-62 UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydroge... 242 2e-62 UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales... 242 2e-62 UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota R... 241 3e-62 UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchae... 240 8e-62 UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria ... 239 1e-61 UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 ... 238 3e-61 UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasm... 238 4e-61 UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerot... 237 4e-61 UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomu... 235 2e-60 UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9... 234 4e-60 UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaprote... 234 4e-60 UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit ... 234 5e-60 UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 234 6e-60 UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 ... 233 8e-60 UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 ... 233 9e-60 UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 233 1e-59 UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobac... 233 1e-59 UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 233 1e-59 UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocell... 232 2e-59 UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria R... 232 2e-59 UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 232 2e-59 UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago ma... 231 4e-59 UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchae... 231 4e-59 UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydoth... 231 5e-59 UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malasse... 230 6e-59 UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular ... 230 9e-59 UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 229 1e-58 UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria R... 229 2e-58 UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotat... 228 2e-58 UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithioba... 228 3e-58 UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 228 4e-58 UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidal... 226 9e-58 UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae R... 226 1e-57 UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae... 226 1e-57 UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepI... 226 1e-57 UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 ... 226 1e-57 UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma... 226 2e-57 UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteri... 225 2e-57 UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria R... 224 3e-57 UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacter... 224 5e-57 UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, put... 223 7e-57 UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria R... 223 1e-56 UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japoni... 221 3e-56 UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured ... 221 3e-56 UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular o... 221 3e-56 UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neoricketts... 221 4e-56 UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desul... 220 6e-56 UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10... 220 7e-56 UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. ... 220 9e-56 UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsia... 219 1e-55 UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Ric... 219 1e-55 UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobac... 219 2e-55 UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus ce... 219 2e-55 UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 219 2e-55 UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=... 218 2e-55 UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular o... 217 6e-55 UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimona... 217 8e-55 UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 ... 217 8e-55 UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 ... 217 8e-55 UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 216 1e-54 UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria ... 216 1e-54 UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_L... 216 1e-54 UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhab... 216 1e-54 UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodosp... 216 1e-54 UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobact... 216 1e-54 UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 215 2e-54 UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_A... 215 2e-54 UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subuni... 214 5e-54 UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanoba... 214 5e-54 UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonosp... 214 5e-54 UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 214 5e-54 UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria R... 213 8e-54 UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteo... 213 8e-54 UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular ... 213 1e-53 UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular o... 213 1e-53 UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 ... 213 1e-53 UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus... 213 1e-53 UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whippl... 213 1e-53 UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=P... 213 2e-53 UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria R... 212 2e-53 UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria R... 212 2e-53 UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromo... 212 2e-53 UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteo... 212 3e-53 UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria Re... 211 3e-53 UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 211 3e-53 UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10... 211 3e-53 UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=u... 211 4e-53 UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocys... 211 5e-53 UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistip... 210 7e-53 UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+]... 210 8e-53 UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus te... 209 1e-52 UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine d... 209 2e-52 UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacte... 208 3e-52 UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira ... 208 3e-52 UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira... 208 3e-52 UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaprote... 208 4e-52 UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphyloco... 208 5e-52 UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subuni... 207 6e-52 UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular or... 207 7e-52 UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromat... 206 8e-52 UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobac... 206 9e-52 UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma ... 206 9e-52 UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 ... 206 1e-51 UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collins... 206 1e-51 UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfuroco... 206 2e-51 UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycet... 206 2e-51 UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia R... 205 2e-51 UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebact... 205 3e-51 UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacte... 203 9e-51 UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella f... 203 1e-50 UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomyce... 203 1e-50 UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 ... 202 2e-50 UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria R... 201 3e-50 UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobilunc... 201 3e-50 UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer s... 201 4e-50 UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococ... 201 5e-50 UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospir... 201 5e-50 UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12... 201 6e-50 UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter... 200 8e-50 UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 200 8e-50 UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmid... 200 1e-49 UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 ... 199 1e-49 UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia ba... 199 1e-49 UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobact... 199 1e-49 UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular ... 199 2e-49 UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collins... 198 4e-49 UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobacul... 198 4e-49 UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 ... 198 5e-49 UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae... 198 5e-49 UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce... 196 1e-48 UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteo... 196 1e-48 UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidob... 196 2e-48 UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes ... 196 2e-48 UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibr... 195 3e-48 UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglob... 195 3e-48 UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 ... 195 3e-48 UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 ... 195 3e-48 UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydrooro... 194 3e-48 UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacte... 194 4e-48 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 194 5e-48 UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic... 194 5e-48 UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellula... 194 6e-48 UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 194 7e-48 UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomy... 193 9e-48 UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 ... 193 1e-47 UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonprot... 193 1e-47 UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerot... 193 1e-47 UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=St... 192 1e-47 UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family prote... 192 1e-47 UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroi... 192 1e-47 UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 ... 192 2e-47 UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacter... 192 2e-47 UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family ... 192 2e-47 UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold... 192 3e-47 UniRef50_A7H8H3 Dihydroorotate dehydrogenase n=4 Tax=Anaeromyxob... 191 3e-47 UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondr... 190 7e-47 UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae Re... 190 8e-47 UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (c... 190 8e-47 UniRef50_A8RT96 Putative uncharacterized protein n=1 Tax=Clostri... 189 2e-46 UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1... 189 2e-46 UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 189 2e-46 UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinom... 188 3e-46 UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, put... 188 3e-46 UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacte... 188 3e-46 UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella ... 188 3e-46 UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus ... 187 4e-46 UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=ca... 187 5e-46 UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyru... 186 1e-45 UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter... 186 2e-45 UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit ... 185 3e-45 UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sede... 184 4e-45 UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirell... 184 5e-45 UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flav... 183 8e-45 UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacte... 182 1e-44 UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 ... 182 2e-44 UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 181 3e-44 UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=ca... 176 1e-42 UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomyce... 176 1e-42 UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 175 3e-42 UniRef50_B3DVT8 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 174 6e-42 UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidoba... 174 7e-42 UniRef50_C2MA24 Dihydroorotate dehydrogenase 2 n=1 Tax=Porphyrom... 174 7e-42 UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopol... 172 2e-41 UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacte... 172 2e-41 UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaprote... 172 3e-41 UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 171 3e-41 UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/... 171 4e-41 UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Cl... 171 7e-41 UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobaci... 169 1e-40 UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 ... 169 1e-40 UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistip... 169 2e-40 UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotoga... 168 3e-40 UniRef50_C4T7U5 Dihydropyrimidine dehydrogenase n=1 Tax=Yersinia... 168 4e-40 UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bactero... 167 1e-39 UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobac... 166 2e-39 UniRef50_Q2LR94 TRNA-dihydrouridine synthase n=2 Tax=Deltaproteo... 165 2e-39 UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 ... 165 3e-39 UniRef50_C4Z9L8 tRNA-dihydrouridine synthase n=26 Tax=Firmicutes... 163 1e-38 UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=... 161 4e-38 UniRef50_B3EQ67 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 161 5e-38 UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroid... 161 5e-38 UniRef50_Q7US31 Putative uncharacterized protein n=1 Tax=Rhodopi... 159 1e-37 UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=... 159 2e-37 UniRef50_C9XSF8 tRNA-dihydrouridine synthase n=24 Tax=Clostridia... 158 4e-37 UniRef50_C8W3U6 TIM-barrel protein, nifR3 family n=8 Tax=Clostri... 155 3e-36 UniRef50_C0WDP2 Putative uncharacterized protein n=1 Tax=Acidami... 154 6e-36 UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 ... 154 6e-36 UniRef50_D2RLJ7 TIM-barrel protein, nifR3 family n=1 Tax=Acidami... 154 7e-36 UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 ... 152 2e-35 UniRef50_A9KHE5 TIM-barrel protein, nifR3 family n=2 Tax=Clostri... 152 2e-35 UniRef50_B3QWF2 TIM-barrel protein, nifR3 family n=26 Tax=Bacter... 151 4e-35 UniRef50_Q1IVR5 Dihydrouridine synthase TIM-barrel protein nifR3... 151 6e-35 UniRef50_B8GCQ5 TIM-barrel protein, nifR3 family n=6 Tax=Chlorof... 151 6e-35 UniRef50_C3MBL4 tRNA-dihydrouridine synthase n=1 Tax=Rhizobium s... 149 2e-34 UniRef50_A0LJ96 Putative TIM-barrel protein, nifR3 family n=1 Ta... 148 5e-34 UniRef50_Q31II6 Dihydrouridine synthase n=1 Tax=Thiomicrospira c... 147 5e-34 UniRef50_Q5M689 Possible transcriptional regulator n=25 Tax=Stre... 147 6e-34 UniRef50_A9NE09 tRNA-dihydrouridine synthase n=2 Tax=Mollicutes ... 147 1e-33 Sequences not found previously or not previously below threshold: >UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria RepID=YEIA_ECOLI Length = 411 Score = 417 bits (1072), Expect = e-115, Method: Composition-based stats. Identities = 411/411 (100%), Positives = 411/411 (100%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR Sbjct: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA Sbjct: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG Sbjct: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR Sbjct: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL Sbjct: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ Sbjct: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL Sbjct: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 >UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14 Tax=Bacteria RepID=A5VL42_LACRD Length = 432 Score = 402 bits (1034), Expect = e-111, Method: Composition-based stats. Identities = 268/413 (64%), Positives = 325/413 (78%), Gaps = 2/413 (0%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF--FIANEVS 58 M+ KDLS+ F GV F NPFCLSSSPVGNCYEMC AYD GWGG+V+KT+ F +EVS Sbjct: 1 MIKKDLSVDFLGVHFENPFCLSSSPVGNCYEMCKNAYDAGWGGIVYKTLSPTHFKIDEVS 60 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 PRFD L KED F+ FKNMEQ++EHPLE++LA +RRLKE+YP+KVLIASIMGE + W Sbjct: 61 PRFDELAKEDMHFVAFKNMEQLSEHPLEQDLADMRRLKEEYPNKVLIASIMGETLEDWTN 120 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 LA+LV E GADMIE NFSCPQMTSH MGSDVG +PEL +K C AVKRG++LP+LAKMTPN Sbjct: 121 LAKLVTETGADMIELNFSCPQMTSHTMGSDVGTNPELCKKNCEAVKRGTSLPVLAKMTPN 180 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I M V A GGADG +AINTVKSI ++DL +K+G+P ++GKSS+SG SGKAVKPIA Sbjct: 181 ITTMVPVVKACLEGGADGFSAINTVKSIVDVDLKKKVGLPNIDGKSSVSGLSGKAVKPIA 240 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LRF+QQ+R+ L PISGIGGIETWEDAAEF+LLGA TLQVTT IM+YGYRI++D+ + Sbjct: 241 LRFLQQLRSAAGLEQLPISGIGGIETWEDAAEFILLGATTLQVTTAIMEYGYRIIDDLTN 300 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGG 358 GL HY+ +Q D LQ++VGLAN NI+P LDR+Y VYP+I+ DKC+GCGRC+ISC DG Sbjct: 301 GLMHYMEEQHVDHLQDLVGLANKNIIPTNQLDRNYKVYPKIDWDKCIGCGRCFISCQDGA 360 Query: 359 HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEHPVTL 411 HQA+ W ++ R P + KCVGC LC VCPVG I+LG V+ K G K +P + Sbjct: 361 HQALTWDDEKRQPVFDKSKCVGCQLCALVCPVGAIKLGLVEIKPGHKGNPAEI 413 >UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Tax=Bacteroides cellulosilyticus DSM 14838 RepID=UPI0001968A99 Length = 494 Score = 342 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 207/397 (52%), Positives = 272/397 (68%), Gaps = 3/397 (0%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 +LS+ FCG++ NPF L+SSPV + +EMC A+D GW GV +KTI F+ + EVSPRF Sbjct: 98 TQAELSVNFCGIRCENPFFLASSPVASSFEMCCHAFDAGWAGVSYKTISFYQSREVSPRF 157 Query: 62 DHLV-KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 D L + F GFKN+EQ++ H EEN +RRLKE YP+KV+IASIMG N +W LA Sbjct: 158 DALPGEHPFSFCGFKNLEQLSPHSAEENFEIIRRLKERYPEKVIIASIMGRNCDEWTVLA 217 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 R+ +EAGAD+IECNFSCPQM +GSD+GQ +L+ Y RA ++GS LP++AKMTPNIG Sbjct: 218 RMAEEAGADLIECNFSCPQMAKQGLGSDIGQDQDLIALYTRATRKGSRLPIIAKMTPNIG 277 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 +M A+ A GA+ +AAINTVKSIT I+ P + G+S++ GYSG+AVKPIALR Sbjct: 278 NMELPAMTAIANGANSLAAINTVKSITRINTENFSSYPDIGGQSAVGGYSGQAVKPIALR 337 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 FI+ + ++P L+ P+ GIGGI TW+DA +F+LLG LQV T +M+YGYRI++ + GL Sbjct: 338 FIRDLASYPPLKGIPLFGIGGITTWQDALDFILLGCTALQVCTSVMEYGYRIIDHLKEGL 397 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 S Y+ SL E+ GLA N+V E LDR ++ I+ +C+ CGRCYISC DGGHQ Sbjct: 398 SIYMKQHDIASLDELRGLALPNLVQPEQLDRERKLHCEIDSRRCIHCGRCYISCLDGGHQ 457 Query: 361 AMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGE 397 A+ W + RTP + CVGC LC VCP I L Sbjct: 458 AIGW--EKRTPMIDKSLCVGCGLCTLVCPTEAISLVN 492 >UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria RepID=A9GKC4_SORC5 Length = 462 Score = 331 bits (848), Expect = 4e-89, Method: Composition-based stats. Identities = 181/434 (41%), Positives = 245/434 (56%), Gaps = 35/434 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLSI F G+K PNPF L+S+P N + +A+D GWGG V+KT+G VS RF Sbjct: 1 MADLSIDFAGIKSPNPFWLASAPPTNTGDQVRRAFDAGWGGAVWKTLG-NPIVNVSSRFG 59 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + +T +G N+E I + PL+ NL +R +K YP LIAS+M E + +W E+ R Sbjct: 60 GIDYGNTRLMGLNNVELITDRPLDVNLKEMREIKRRYPGHALIASLMVETKDEWREIIRK 119 Query: 123 VQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ GAD +E NF CP M MGS VG P ++++ R +T P++ K+TPN+GD Sbjct: 120 AEDTGADGLELNFGCPHGMCERGMGSAVGNEPAVLQEIARWAVEFATTPVIVKLTPNVGD 179 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E A R GA G++ INTVKS+ +DL + + +P V G S+ GY G AVKPIAL Sbjct: 180 ILEPGEAVLRSGAHGVSLINTVKSLMGVDLERMVPLPRVGGASTNGGYCGPAVKPIALHL 239 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q+ HP + PISGIGGI DAAEF+ LGA ++QV T +M YGYRIVE+M GLS Sbjct: 240 LSQLARHPGVGRLPISGIGGISNSRDAAEFIALGATSVQVCTAVMHYGYRIVEEMIEGLS 299 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQA 361 +L D G S+ E+ G A + +LD SY V I+ DKC+GC CY++C DG HQ Sbjct: 300 DWLDDHGMRSVNELRGRAIPQVQEWGELDLSYRVVADISADKCIGCQLCYVACMDGAHQC 359 Query: 362 MEWSEKT--------------------------------RTPHCNTEKCVGCLLCGHVCP 389 + +T R P + E+C+GC LC VCP Sbjct: 360 IHLPGRTEAEARAAGHTHLPKVLPDRAVTADPSGDAAPSRVPFVDEEECIGCNLCALVCP 419 Query: 390 V-GCIELGEVKFKK 402 V GCI + EV K Sbjct: 420 VPGCITMREVPSGK 433 >UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydrouracil dehydrogenase (NAD+) / dihydroorotate oxidase B, catalytic subunit n=94 Tax=Bacteria RepID=Q01P61_SOLUE Length = 446 Score = 313 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 176/443 (39%), Positives = 246/443 (55%), Gaps = 39/443 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS F G++ PNPF L+S P NC E +A+D GWGG V+KTIG VS R+ Sbjct: 1 MADLSTNFAGIRCPNPFWLASGPPTNCGEQIMRAFDAGWGGAVWKTIG-EPIVNVSSRYS 59 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM-GENEQQWEELAR 121 + +G N+E I++ P+E NL + +K+ YP +IAS+M + W ++ + Sbjct: 60 SVDWNGQRMMGLNNIELISDRPIETNLREITEVKKRYPKHAVIASLMVESTREAWHDIVK 119 Query: 122 LVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++AGAD +E NF CP M+ MG+ VGQ P+ VK + P+L K+TPNI Sbjct: 120 RSEDAGADGLELNFGCPHGMSERGMGAAVGQVPDYSCMITEWVKEVARTPVLVKLTPNIT 179 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ VA AAKRG AD ++AINT+ SIT IDL+ P V GK+S GY G AVKPIAL Sbjct: 180 DIRAVARAAKRGRADALSAINTINSITGIDLDTFTPRPNVGGKTSHGGYCGPAVKPIALH 239 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 +QQ+ + PISGIGGI W +AAEF+LLG T+QV T M YG+RIVEDM GL Sbjct: 240 LVQQIASD-PAVGLPISGIGGIGGWREAAEFILLGCGTVQVCTAAMHYGFRIVEDMIDGL 298 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQ 360 S+++ ++GF ++++ GL+ + + LD +Y + RIN DKC+GC CY++C+DG HQ Sbjct: 299 SNWMDEKGFRTIEDFRGLSVPRVTDWKHLDLNYKIVARINRDKCIGCDLCYVACWDGAHQ 358 Query: 361 AMEWSEK----------------------------------TRTPHCNTEKCVGCLLCGH 386 + R P + +CVGC LC Sbjct: 359 CIHLDGHAVPAAVEAASRASIAVTPIAKLDAAQAALGTTPPHRIPRVDEHECVGCNLCWL 418 Query: 387 VCPV-GCIELGEVKFKKGEKEHP 408 VCPV CI + +V+ + + Sbjct: 419 VCPVEHCITMEKVETGQSAQSWA 441 >UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E2T4_GEOLS Length = 398 Score = 312 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 135/399 (33%), Positives = 215/399 (53%), Gaps = 11/399 (2%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + L T+ GV F NPF L+S+P +M +A++ GWGG V KT+ + + RF Sbjct: 1 MPVVLDSTYLGVVFRNPFVLASAPPTATADMVRRAFEAGWGGAVIKTLIREPVHNLPNRF 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG--ENEQQWEEL 119 + + GF+N+E ++E +E A+R +K D+PD +I SIMG + +W L Sbjct: 61 AAIRHGNR-ITGFENLELLSEQAPDEWYRAIRCIKADFPDCPIIGSIMGAANSPDEWHSL 119 Query: 120 ARLVQEAGADMIECNFSCPQM-TSHAMGSDVGQSPELVEKYCRAV--KRGSTLPMLAKMT 176 A Q+AGAD++E NFSCP G+ +GQ+P+ + R V + T+P++ K+T Sbjct: 120 ALGCQDAGADLLELNFSCPHGYPERGRGAAIGQNPDYAAQITRWVTDCKEITIPVIPKLT 179 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 + ++ +A GA G AINT+ S DL P + GK+S GYSG +KP Sbjct: 180 AAVANIQNIAEELALAGAHGFCAINTIPSFFGFDLRTLRPKPDIGGKTSYGGYSGPGIKP 239 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 IALR + ++ + P+ GGI DA EF+LLGA +Q+ T +M +G+ I++ M Sbjct: 240 IALRAVSEL---CQSPGLPVMASGGIANGFDAVEFMLLGAPVVQMATEVMLHGFGIIDRM 296 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYD 356 L ++ F + + +GL ++ + L +V PR+ ++C CG C+ +C D Sbjct: 297 QQELREFMTWHDFTAPVDFIGLCRDSATSFKKLPAGTMVSPRLLAERCTHCGACFTACRD 356 Query: 357 GGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 GG+QA+ W++ P + C C LC HVCP G +++ Sbjct: 357 GGYQAISWNKG--LPGIDPTVCKSCSLCSHVCPAGALQM 393 >UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MJK5_ALKOO Length = 372 Score = 293 bits (750), Expect = 7e-78, Method: Composition-based stats. Identities = 117/393 (29%), Positives = 188/393 (47%), Gaps = 24/393 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS+ F G+ NP +S+ P+ M KA + G G VV KTI I V PR Sbjct: 1 MDLSVNFLGLSLKNPIIVSAGPLTGSGSMMRKAIEAGAGAVVTKTIANEIRPNVRPRLVK 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 G G N+E + LEE + K V+IA+I+G + +A+ V Sbjct: 61 ------GREGLHNIELYSGFTLEEWENEIAYAKIH--GAVVIANILGHTSSEIAYIAQKV 112 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 ++ GAD +E SCP V P + ++ +AV +P++ K++ N ++ Sbjct: 113 EQFGADAVELGVSCPHGEGLEG---VISEPSKLYEFTKAVVDRIKIPVMVKLSSNTVNVV 169 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 ++A AA++ GA I+ I+TV+SI +D+ + + + GYSG A++PI L I Sbjct: 170 KLARAAEKAGASAISGIDTVRSIAGVDIEKGRVLLP-----TFGGYSGDAIRPIGLAAIA 224 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + PI GIGGI +E E+++LGA+T+QV T I+ GY + + GL+ + Sbjct: 225 SIAQAT---SIPICGIGGITNYEHILEYMMLGASTVQVCTSIILNGYEHISTLLDGLNGW 281 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 +A + + E+ G+A ++ E++ + V + K + C RC SC G + Sbjct: 282 MAQHSYRNFDEIKGMALVSLKSFEEIKQEPYVSQPVGNCKSMQCNRCEKSCIWGAIKVNR 341 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 + + + C GC LC VCP EL Sbjct: 342 EN-----VRVDRKLCTGCGLCVSVCPQRIFELR 369 >UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CDX9_PARTE Length = 997 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 130/426 (30%), Positives = 195/426 (45%), Gaps = 36/426 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF--IANEVSPRFD 62 DLSI GV F NPF L+S+P Y M +A+ GWG V KT VSPR Sbjct: 544 DLSINILGVNFLNPFGLASAPPTTSYPMIKRAFQEGWGFAVVKTFVLDKDAITNVSPRIY 603 Query: 63 HLVKED-TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQ-QWEELA 120 + G+ N+E I+E + L + +K+++P+ VLI SIM ++ + W EL Sbjct: 604 KSTTDPLKQDPGYANIELISEKSAKYWLEGSKAIKKEFPNHVLIGSIMCQHIEQDWRELT 663 Query: 121 RLVQEAG-ADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R + G DM+E N SCP MT MG G++P +V+ C+ V +P++ K+TPN Sbjct: 664 RKCKNEGQFDMLELNLSCPHGMTELGMGRACGENPAIVKDICQWVTSEIDIPVIVKITPN 723 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNID-LNQKIGMPIVNGKSSISGYSGKAVKPI 237 D ++A AAK GGA + NT ++ + D L + G G ++PI Sbjct: 724 YPDSADIAQAAKEGGAKAVTLTNTFPTLMDPDPLGTPWPAVGEENNVTYGGGCGSMLRPI 783 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR------ 291 ALR ++ D I G GGI + A FL GA+ Q+ + + + Sbjct: 784 ALRKTSEVAKAI--PDIAIFGSGGIIQGDHALSFLRYGASAFQICSAVQDQDFATVLYDL 841 Query: 292 -------IVEDMASGLSHYLADQG-------------FDSLQEMVGLANNNIVPAEDLDR 331 + + + L+ +VG ++I ++ R Sbjct: 842 KTSFQAHLYASYNLNQKQWKGQFPTSQKQKPSFAFSSNNKLKNLVGSGLHHIKDIAEMKR 901 Query: 332 SYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPV- 390 + P+IN D C+ CGRCY++C D G+QA+++ P E C GC LC VCPV Sbjct: 902 QDFLVPQINEDSCLKCGRCYLTCLDSGYQAIKFDNFNSFPTIIEELCTGCALCHAVCPVE 961 Query: 391 GCIELG 396 G I + Sbjct: 962 GSISME 967 >UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D2W4_DESK1 Length = 407 Score = 289 bits (739), Expect = 2e-76, Method: Composition-based stats. Identities = 112/422 (26%), Positives = 174/422 (41%), Gaps = 47/422 (11%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS+ G+K NP ++ PV + D G G VV KTI A P Sbjct: 5 MADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPRPSMA 64 Query: 63 --------------------HLVKEDTG----FIGFKNMEQIAEHPLEENLAALRRLKED 98 + D+G N E ++ P E L L + Sbjct: 65 AVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPLVKS 124 Query: 99 YP---DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPEL 155 Y V IASI G ++ L V++AG IE +G+ Sbjct: 125 YCEEKGAVFIASI-GYTPEELSLLGPKVEKAGVQAIEF-----------STHYIGRDYRP 172 Query: 156 VEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 V + +A++ +P+ K++P ++ E+ ++ G DGI A NT+ +ID+ Sbjct: 173 VIEAAKALRESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVE--T 230 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 G+PIV G SG A+KP+AL + Q+ + + P+ G+GGI D E+ + G Sbjct: 231 GLPIVGGPYGYGWMSGPALKPLALAVVSQVALNTK---LPVIGVGGISRGVDVIEYFMAG 287 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV 335 A+ +Q+ T + G + + ++ +L G+ S+ ++ GLA + P R + Sbjct: 288 ASAVQICTAALIEGPQAFARIIREVNEWLDRHGYTSILDVKGLALKYLKPEP--RRVWAQ 345 Query: 336 YPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 P ++ KC+GCG C C +E S R N KC GC LC VCP I Sbjct: 346 PPVVDEKKCIGCGFCEQVCNYDAVH-VEESSGKRVARVNIMKCYGCGLCTSVCPTRAIHF 404 Query: 396 GE 397 E Sbjct: 405 IE 406 >UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 Tax=Staphylothermus marinus F1 RepID=A3DL41_STAMF Length = 406 Score = 288 bits (736), Expect = 4e-76, Method: Composition-based stats. Identities = 107/423 (25%), Positives = 171/423 (40%), Gaps = 46/423 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF- 61 L + G+K NP ++ PV EM D G G VV KTI A P Sbjct: 1 MVSLEVEIAGLKMKNPLMNAACPVSRDAEMMKALIDNGVGAVVAKTISVRPAIVPRPSMG 60 Query: 62 -------------------DHLVKEDTG----FIGFKNMEQIAEHPLEENLAA---LRRL 95 +V D+G N E ++ P E + + Sbjct: 61 AVDRGIVRSQILKTFGPGNVRIVNADSGNYRFIYALLNAELWSDIPAEHYFEREYPIVKK 120 Query: 96 KEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPEL 155 + I SI G ++ + L Q+AGA+ IE +G+ Sbjct: 121 YAEEKGVPFIISI-GYKPEELQLLGPKCQKAGANAIEF-----------STHYIGKDYRP 168 Query: 156 VEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI 215 V + +A++ +P+ AK++P ++ E+ ++ G DGI A NT+ +ID+ Sbjct: 169 VVEAAKALREVVDIPIFAKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDIE--T 226 Query: 216 GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLG 275 G+PIV G + SG A+KP+AL + + P+ G+GGI D E+ + G Sbjct: 227 GLPIVGGPNGYGWMSGPALKPLALA---VVAEAAKNTHLPVIGVGGISKGTDVIEYFMAG 283 Query: 276 AATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV 335 A+ +Q+ T + G + + + +L G+DS+ ++ G A + P R + Sbjct: 284 ASAVQICTAALIEGLGVFRRIEKEIESWLKRHGYDSILDVKGKALKYLKPEP--RRVWAK 341 Query: 336 YPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 P ++ KC+GCG C C + + E R N + C GC LC VCP I Sbjct: 342 PPVVDPKKCIGCGFCEQVCDYNAVKVVPNEEGKRIAQVNYDLCYGCGLCTSVCPTRAIHF 401 Query: 396 GEV 398 E Sbjct: 402 EEE 404 >UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 Tax=Thermosipho RepID=A6LJ97_THEM4 Length = 360 Score = 279 bits (714), Expect = 1e-73, Method: Composition-based stats. Identities = 107/393 (27%), Positives = 165/393 (41%), Gaps = 34/393 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS G+K NP +S P+ YE TG G +V KTI AN P Sbjct: 1 MDLSTEISGIKIENPLMPASGPLVGDYEKIKFIDSTGVGAIVTKTISTKAANVPRPCIY- 59 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 + F+ N E +E P E + + ++ K LI S+ G + E L + Sbjct: 60 ---GENNFV--MNAELWSELPPETWIKEILPKLKNELKKPLIVSV-GYTIEDMEILIPQL 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 E AD E VG+ + +A+++ + P+ K++P+I D Sbjct: 114 NEY-ADAFEI-----------STHYVGKDYNTIANIVKAIRKNTNKPIFMKLSPHIPDPV 161 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E GA+GI AIN+ ID+ + + + + SG +KPIAL ++ Sbjct: 162 EFTKTILENGANGIVAINSWGPTMKIDIKNRKTL--IGNEKGQVWLSGPVIKPIALSIVK 219 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 +R D I G+GGI++ ED EFLL GA +Q+ + + +G I E + + L Sbjct: 220 TIRDAF--PDITIIGVGGIKSAEDVIEFLLSGADAVQLLSSALIFGKDIYEKILNQLPST 277 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 L F+S+ E++ + YP++N +KC CG C C + Sbjct: 278 LEKYEFNSINEVLNT-----ELTVGTVKYTPNYPKVNHEKCTLCGICEKVCPYFAIKI-- 330 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELG 396 + NT KC GC LC CP I++ Sbjct: 331 ----DKKVKINTYKCFGCGLCESRCPTKSIKIK 359 >UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2ELU8_TRIVA Length = 811 Score = 275 bits (702), Expect = 3e-72, Method: Composition-based stats. Identities = 134/455 (29%), Positives = 204/455 (44%), Gaps = 56/455 (12%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L FCG+KF NP +SS+PV YE + G G V KTI + + Sbjct: 361 HVSLETEFCGMKFKNPSGISSAPVSGTYECIRNCFKAGMGWAVTKTILPT-KDVIRENDF 419 Query: 63 HLVKEDTG---FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN-EQQWEE 118 +VK D F N+ + EH E L +++LK ++PD+VL+ASI + +++W+ Sbjct: 420 RIVKADENPGPSGSFCNICMMTEHTEEYWLDTIKKLKAEFPDRVLVASIATSDSKERWQN 479 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGS------------DVGQSPELVEKYCRAVKRG 166 L + V AGAD +E N SCP G +G P V++ + VK Sbjct: 480 LVKNVIAAGADALELNLSCPNEVHGEGGCKGGFDTENKIGMALGTHPISVKRISQYVKEA 539 Query: 167 STLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS-- 224 +T+P K+TPNI D ++A AA GGADG+A INTV I + +P V + Sbjct: 540 TTVPFFVKLTPNITDPIDIAQAALEGGADGVAMINTVSGIAKFWPD-GTPLPQVGKEKYV 598 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG V+PIALR I ++ + PI GIGGI + A + L G++ Q+ + Sbjct: 599 LSGGLSGDQVRPIALRQISRVHNKF--PEMPILGIGGIGSGYTALQHLYAGSSVFQMCSA 656 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIV-------------------- 324 I +Y Y IV ++ +GL YL L+ + Sbjct: 657 IQRYSYDIVREVNAGLQFYLYSWSRPDLRAKLSHYTEMKTLPIQVPIPEDTKQDRKIPTL 716 Query: 325 ------------PAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPH 372 E D ++ ++ I+ C+ CG+C +SC D +A+ + Sbjct: 717 AELRGLGAKRVVQRESFDINWTLHAEIDDATCLQCGKCALSCRDNSVEAIHLVDGKWK-- 774 Query: 373 CNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEKEH 407 N ++C+GC LC VCPV + + E + +K Sbjct: 775 VNHDECIGCALCHSVCPVQAMHMVESEKRKNWHHR 809 >UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0EHW2_ENTDI Length = 901 Score = 274 bits (700), Expect = 5e-72, Method: Composition-based stats. Identities = 135/452 (29%), Positives = 212/452 (46%), Gaps = 59/452 (13%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKT--IGFFIANEVSPRF 61 D+S+T G+K+ NPF +SS+PV Y+ + + G+G + KT + I R Sbjct: 436 VDISVTVDGIKYENPFGISSAPVSGTYDHLKRCFQAGFGFALTKTYPLEKDIQKNNHIRI 495 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-ENEQQWEELA 120 V + + N+ I+EH L ++++LK ++P+KV+IASIM +N W LA Sbjct: 496 VK-VYDSQESTSYNNIVMISEHSHHYWLESIKKLKAEFPNKVVIASIMCMDNADDWHLLA 554 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSD----------------VGQSPELVEKYCRAVK 164 +L +EAGAD +E NFSCP G++ +G SP +E+ R V Sbjct: 555 KLSEEAGADALELNFSCPNECHGNDGNEGGCEGGFKSHNAMAMAIGVSPAAIERCTRYVV 614 Query: 165 RGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 +P+ K+TPN+G++ E+A AA RGGA G++ INTV I+ I L+ + ++ Sbjct: 615 ESVHIPVYPKLTPNVGNIEELAAAAMRGGASGVSTINTVFGISEITLSGHPWPQVGVERN 674 Query: 225 S-ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTT 283 + G SG V+PIA+R I Q+ H E + GIGG+ + E A + + GA+ +Q+ + Sbjct: 675 TISGGLSGDLVRPIAIRQIAQVLRHNENVRGHLLGIGGVRSAETAMQLIYTGASVVQMCS 734 Query: 284 GIMQYGYRIVEDMASGLSH------------YLADQGFDSLQEMVGLANNNIVPAEDLD- 330 + ++ Y IV+++ SG YL QG +S + + Sbjct: 735 SVQKWSYDIVDEIISGTKFILYCWSRPDLRGYLNSQGVESFMPYGEKTPFWTLDNKQDKP 794 Query: 331 -----------------------RSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK 367 + C+GCG C +SC D A+ + Sbjct: 795 VPKLAEVTGIALKHIGERKILEGPEKWRVNAHIKNNCIGCGSCALSCRDNSTTAI--VKD 852 Query: 368 TRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 + EKC+GC LC VCPV IE +VK Sbjct: 853 GNRYRVDDEKCIGCALCSSVCPVNAIEYVKVK 884 >UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q23YG3_TETTH Length = 1080 Score = 272 bits (695), Expect = 2e-71, Method: Composition-based stats. Identities = 123/436 (28%), Positives = 195/436 (44%), Gaps = 41/436 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF--IANEVSPRF 61 D+S CGVK NPF L+S+P Y M A+++D G+ V KT VSPR Sbjct: 620 VDISTEICGVKMENPFGLASAPPTTSYPMIARSFDIGYDFAVVKTAVLDKDTVFNVSPRI 679 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-ENEQQWEELA 120 + + N+E ++E L+ + +++K+DYP+KVLI S+M N+Q W ++ Sbjct: 680 FKVPDPLRQECSYGNIELVSEKSLKYWVEGAKQIKKDYPNKVLIGSLMAAYNQQDWIDIM 739 Query: 121 RLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 V++A DMIE N SCP M MG G+ P++V V + +P++ K+TPN Sbjct: 740 HQVKDAPFDMIELNLSCPHGMNEKGMGRACGEDPDIVRDITSWVTSQTKIPIIVKITPNY 799 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKI-GMPIVNGKSSISGYSGKAVKPIA 238 G +A AA GGA + NT+ + + + + V + G +G ++P A Sbjct: 800 GQAEILAKAAYEGGAKAVTLTNTMPGLVDPYPDGESFNGVGVEKNVAPGGSTGSILRPFA 859 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE---- 294 +R + + I GGI + + +L GA LQ+ + + V Sbjct: 860 MRKCVDVAKFV--PEIDIFASGGIISGDHGINYLHYGAKALQICSAVQNLDAATVFYDLK 917 Query: 295 -----DMASGLSHYLADQGF------------------------DSLQEMVGLANNNIVP 325 +M + S L G+ + E+VG + P Sbjct: 918 TSLQANMYANSSQKLKKNGWKGQYPPYQFEKLKTPTSVETPQKVPKILEIVGAKLAKVSP 977 Query: 326 AEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCG 385 E + + I P I+ D C+ CGRCY++C D G+QA+++ P E C GC +C Sbjct: 978 IEKMSKEIIQVPEISKDSCLECGRCYVACSDSGYQAIQFDGYNNVPRIIEEDCTGCAICV 1037 Query: 386 HVCPV-GCIELGEVKF 400 CPV I++ K Sbjct: 1038 ASCPVENAIKMVPRKL 1053 >UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehydrogenase-like protein n=14 Tax=cellular organisms RepID=Q9LVI9_ARATH Length = 426 Score = 271 bits (692), Expect = 4e-71, Method: Composition-based stats. Identities = 140/345 (40%), Positives = 200/345 (57%), Gaps = 12/345 (3%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIAN--EVSP 59 DLS+T G+K PNPF + S P G Y + +A+D GWG V+ KT+ + V+P Sbjct: 48 SEPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLDASKVINVTP 107 Query: 60 RFDHLVKEDTGF-----IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NE 113 R+ L G IG++N+E I++ PLE L RLK++YPD++LIAS+M E N+ Sbjct: 108 RYARLRTGSNGSAKTDVIGWQNIELISDRPLETMLKEFERLKKEYPDRILIASVMEEYNK 167 Query: 114 QQWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 WEEL V++ G D +E NFSCP M MG+ VGQ L+++ C + +T+P+ Sbjct: 168 TAWEELIDRVEQTGVDALEINFSCPHGMPERRMGAAVGQDCALLDEVCGWINAKATVPVW 227 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 AKMTPNI D+ E A + + G +GIAAINT+ S+ ID+ P V G S+ GYS K Sbjct: 228 AKMTPNITDITEPARVSLKSGCEGIAAINTIMSVMGIDMKTLRPEPCVEGYSTPGGYSYK 287 Query: 233 AVKPIALR---FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 AV+PIAL I +M D +SGIGG+ET DAAEF+LLG+ T+QV TG+M +G Sbjct: 288 AVRPIALAKVMNIAKMMKSEFSEDRSLSGIGGVETGYDAAEFILLGSNTVQVCTGVMMHG 347 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYI 334 Y V+ + + L ++ F +++E G + DL + Sbjct: 348 YGHVKTLCAELKDFMKQHNFSTIEEFRGHSLQYFTTHTDLVKRQK 392 >UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga lettingae TMO RepID=A8F8E8_THELT Length = 386 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 92/403 (22%), Positives = 171/403 (42%), Gaps = 23/403 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF-D 62 DLS + G+K NP ++SS + + KA + G VV K++ +SP Sbjct: 1 MDLSCEYVGIKLKNPIIVASSGLAENLKNMKKAEEHGAACVVAKSLFEEKICRISPTPRF 60 Query: 63 HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 +++ G + F + EQ + E +R+ +I SI ++ W + Sbjct: 61 EIIERKMGKLRSQTFYSFEQASPFDAHEYFEEIRKAVNTLS-IPVIPSINCVTDEGWSQY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 AR+ + AGA +E N SCP + G DV E + + V+ +P++ K+ + Sbjct: 120 ARMAEGAGAPALELNVSCPHGSISFRGGDVE---EKILSVAKIVRDSVKIPLIVKLPMQL 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 +A +R G DG+ N + +D+N + P+++ +G+ G L Sbjct: 177 SSPLSMAKMLERSGIDGVVMFNRLTG---LDINLEKERPVLHE--GYAGHGGPWAFNYVL 231 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I + ++ GG+ + ED +++ GA ++V + I GY ++ + Sbjct: 232 RWIA---ASSPHLNISVAASGGVGSGEDIIKYIYAGANAVEVCSLIYLSGYEAIDMLLEQ 288 Query: 300 LSHYLADQGFDSLQEMVGLANNNIV-PAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGG 358 + ++ + + ++ G + + E +DR ++ +IN C CG C C Sbjct: 289 IKAFMERKSYPDFSQIKGKLSGKAILSNEQIDRRHLFKAQINQALCTSCGTCQKVCIYDA 348 Query: 359 HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFK 401 E + +E C GC LC +CPV IE+ + K Sbjct: 349 PYQSE------KSYVISELCDGCGLCVKLCPVKAIEMVKWSEK 385 >UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHS6_KOSOT Length = 361 Score = 267 bits (683), Expect = 4e-70, Method: Composition-based stats. Identities = 102/390 (26%), Positives = 161/390 (41%), Gaps = 34/390 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL+ G++ NP +S P+ + D G G +V KTI A P Sbjct: 1 MDLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAEVPRPCII- 59 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 G N E E+P E+ + LI S+ G + E L + Sbjct: 60 -----AGKNYIMNTELWTEYPPEKWKGEFIPKFREKSSLPLIVSL-GYTVEDLEVLVPMF 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + AD E V PEL++ R VK+ + P+ K P++ + Sbjct: 114 DDL-ADAFEL-----------STHYVADDPELMKHLIRTVKKHTDKPVFLKFDPSVPEPE 161 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +A A + G DGI AIN++ L +++ + SG +KPIAL ++ Sbjct: 162 VMAKAVEEAGGDGIVAINSLG--PGYPLYRELKSSPLGSTHGFGWISGPVIKPIALAMVK 219 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ + + PI G+GGI + +D +F++ GA+ +Q+ +G + YG I + + + L Sbjct: 220 RVASSC---NLPIIGVGGISSADDVIDFIMAGASAVQLLSGALLYGKSIYKKIIADLPKK 276 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 L G++S+ E+ GLA N+ R P+I+ KCV CG C C E Sbjct: 277 LEALGYNSINEIKGLATNSNPEVSYEKR----TPKIDHSKCVKCGVCVEVCPYFALSMEE 332 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCI 393 + E C GC LC CP I Sbjct: 333 Q------VIVDEEACFGCGLCQTKCPTKAI 356 >UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10 Tax=Bacteria RepID=A9BIU8_PETMO Length = 363 Score = 265 bits (677), Expect = 2e-69, Method: Composition-based stats. Identities = 101/393 (25%), Positives = 175/393 (44%), Gaps = 32/393 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 D+S+ G+ P ++ P E KA + G G +V KT+ A P Sbjct: 1 MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAKVPKPNMA 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + GF N E +E LE+ + + V+I G + +E+ Sbjct: 61 QVKG------GFINTELWSELSLEQWIEKEYPQVVETGLPVIIGV--GYTSEDIKEVIPK 112 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 V+ AD E +G P + RA K + LP++ K++P + D+ Sbjct: 113 VERF-ADAFEL-----------STHYLGNDPTPMINSIRAAKETTDLPVMVKLSPQV-DI 159 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + A A+ GADG+ IN+ +D++ + G P++ ++ SG+A+ P+ALR + Sbjct: 160 PKFAKEAENAGADGLVLINSFG--PTLDIDLESGKPLLGSENGFGWLSGQAIFPLALRSV 217 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + P+ G+GGI T ++A + ++ GA +QV T + G +I + + + + Sbjct: 218 FE---AVRSVNIPVVGVGGINTGKEAIKMIMAGAQAVQVCTAAILNGPQIYKKITNEIEK 274 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 YL D F SL+E+ G+A NIV + +++P +N +KC C C SC + Sbjct: 275 YLDDHDFKSLEEIRGIAQKNIVNEANY---NLIFPAVNDEKCTECALCVKSCVYDAIHLI 331 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 ++ + +T KC GC LC C + L Sbjct: 332 ---KELHSVRIDTNKCAGCGLCVTRCNFNALSL 361 >UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B8E1W3_DICTD Length = 390 Score = 264 bits (675), Expect = 4e-69, Method: Composition-based stats. Identities = 101/407 (24%), Positives = 179/407 (43%), Gaps = 23/407 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF-D 62 DLS ++ G++ NP ++SS + + K + G G +V K++ VSP Sbjct: 1 MDLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSLFEEEICRVSPTPRF 60 Query: 63 HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 ++ G + F + EQ + EE + + +I SI + W + Sbjct: 61 EIISRSMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLS-IPVIPSINCITDDGWLKY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 +++ +E GA +E N SCP + G DV E + R V+ +P++ K+ + Sbjct: 120 SKMAEEVGAPALELNVSCPHASISFRGQDVD---ETILHVARIVRENVKIPIVVKLPMQL 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 VA A + G DG+ N + T +D+N PI++G +G+ G L Sbjct: 177 SSPLAVAKALENIGVDGVVMFNRL---TGLDINLDTEKPILHG--GYAGHGGPWAFNYVL 231 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I R H + I+G GG+ + +D A+++L GA +Q+ + + GY I+ + G Sbjct: 232 RWISTSRPHLK---LSIAGSGGVGSGDDVAKYILTGADVVQICSIVYLMGYEIIPRIIDG 288 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLD-RSYIVYPRINLDKCVGCGRCYISCYDGG 358 L ++ ++ + +L + G + ++ R ++ IN D C CG C C Sbjct: 289 LKKFMENKKYSTLSDFRGKVSGKVILGNYEIDRRHLYEAYINSDLCTSCGICKKVCIYDA 348 Query: 359 HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFKKGEK 405 +E K + T+ C GC LC +CP I + V ++ K Sbjct: 349 --PIEKDGK----YFITDLCDGCGLCVRLCPTKAISMVFVGGRENAK 389 >UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 Tax=Clostridiales RepID=C4IB41_CLOBU Length = 362 Score = 262 bits (669), Expect = 2e-68, Method: Composition-based stats. Identities = 104/391 (26%), Positives = 171/391 (43%), Gaps = 34/391 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ T +K NP +S P+ + + + G G +V KTI A V P Sbjct: 1 MNLNTTIGKIKLENPLMPASGPLVGDKDKMSALNEFGVGAMVTKTISSKKAEVVRPCIY- 59 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKEDYPDKVLIASIMGENEQQWEELARL 122 FI N E +E+ E + L +K++ DK LI S+ G ++ E L Sbjct: 60 ---GGKNFI--MNAELWSEYAPEVWIDEFLPSIKKELKDKPLIISV-GYTKEDMEFLIPK 113 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + + AD E VG+ +++ + ++R + P+ KM+P+I D Sbjct: 114 L-DVFADAFEI-----------STHYVGKDLSNIKETLKTIRRFTQKPVFMKMSPHIPDP 161 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 A GI AIN++ NID++++ ++ K SG A+KP+AL I Sbjct: 162 IGFAKMVIENKGSGIVAINSLGPTMNIDIDKRS--VLIGNKEGEVWTSGPAIKPMALALI 219 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 +++ + I G+GGI + +D EFLL GA+ +Q+ + M G + E + L Sbjct: 220 HKIKKAV--PECEIIGVGGISSADDIIEFLLAGASAVQMLSAAMLKGKDLYEKLIEELPK 277 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 L GF+S++E++ + + YP IN DKC C C +C ++ Sbjct: 278 ALKKHGFNSVEEVINE-----KLSIGQVKYEPEYPLINKDKCTNCRLCEKACPYFAITSI 332 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCPVGCI 393 + K +T+ C GC LC CP I Sbjct: 333 DNQIK-----IDTKNCFGCGLCESRCPSKAI 358 >UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PGY1_9FIRM Length = 371 Score = 257 bits (657), Expect = 4e-67, Method: Composition-based stats. Identities = 103/392 (26%), Positives = 170/392 (43%), Gaps = 24/392 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 LS+ F G+ NP +++ P K+ D G VV +TI + V PR Sbjct: 1 MSLSVQFLGMTLKNPVIVAAGPWSCDAAAIQKSIDAGAAAVVTETITLEASTRVCPRLYQ 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 N + LE+ ++R+ + D +LI S+ G E + +A+ V Sbjct: 61 H------GGSLFNTMLYSTIDLEQWEQEIKRIDKR--DSILICSVWGATESETAYIAKKV 112 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + GAD IE + S P + G+S E + Y RAV LP++ K++ + Sbjct: 113 ERLGADAIELSISAP---IGTRSTRFGRSQEQIGGYVRAVVEAVDLPVMVKLSYDASANV 169 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 A ++ GA I+AI+++K + +D+ + + + GYSG ++P+AL Sbjct: 170 AFVHAVEQAGAQAISAIDSLKGLAGVDIEHGMPLMP-----TCGGYSGANLRPVALATTA 224 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + I GIGGIE++E E+++LGA +Q+ + ++ GY + + S L + Sbjct: 225 TLAQLTR---CEICGIGGIESYEHVLEYVMLGANAVQLASTVLLAGYERITRIVSDLRAW 281 Query: 304 LADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAME 363 D +L G A ++P ED+ +V N + CG C SC GG + Sbjct: 282 T-DAHNTTLAAQHGRALQKLIPFEDIPAQQLVCAFQNPCTRIDCGLCAASCLGGGIRLSS 340 Query: 364 WSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 + + C GC LC CP I L Sbjct: 341 DG----FYTVDPDACTGCGLCAARCPEHRIRL 368 >UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax=Eukaryota RepID=DPYD_HUMAN Length = 1025 Score = 257 bits (657), Expect = 5e-67, Method: Composition-based stats. Identities = 121/440 (27%), Positives = 185/440 (42%), Gaps = 62/440 (14%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF--IANEVSPRF 61 D+S+ G+KF NPF L+S+ M +A++ GWG + KT I VSPR Sbjct: 531 VDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRI 590 Query: 62 DHL----VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQW 116 G F N+E I+E ++ LK D+PD ++IASIM N+ W Sbjct: 591 IRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDW 650 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHA-MGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 ELA+ +++GAD +E N SCP MG GQ PELV CR V++ +P AK+ Sbjct: 651 TELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKL 710 Query: 176 TPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLN-QKIGMPIVNGKSSISGYSGKAV 234 TPN+ D+ +A AAK GGA+G+ A NTV + + + + +++ G SG A+ Sbjct: 711 TPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAI 770 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 +PIALR + + FPI GGI++ E +FL GA+ LQV + I + ++E Sbjct: 771 RPIALRAVTSIARALPG--FPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIE 828 Query: 295 DMASGLSHYLADQGFDSLQEMVGLANNNIVPAE----------DLDRSYIVYPRINLDKC 344 D +GL L + + LQ+ G + + + + P + K Sbjct: 829 DYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKK 888 Query: 345 V--------------------GCGRCYISCYDGGHQAMEWSEKT---------------- 368 + C ++ Sbjct: 889 IIAENKIRLKEQNVAFSPLKRNCFI-----PKRPIPTIKDVIGKALQYLGTFGELSNVEQ 943 Query: 369 RTPHCNTEKCVGCLLCGHVC 388 + E C+ C C C Sbjct: 944 VVAMIDEEMCINCGKCYMTC 963 Score = 82.8 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 29/95 (30%), Positives = 54/95 (56%), Gaps = 2/95 (2%) Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 ++ + ++++++G A + +L V I+ + C+ CG+CY++C D G+QA+ Sbjct: 912 FIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAI 971 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCP-VGCIELG 396 ++ +T P T+ C GC LC VCP V CI++ Sbjct: 972 QFDPETHLPTI-TDTCTGCTLCLSVCPIVDCIKMV 1005 >UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1EGR6_9CHLO Length = 434 Score = 256 bits (653), Expect = 1e-66, Method: Composition-based stats. Identities = 138/332 (41%), Positives = 200/332 (60%), Gaps = 7/332 (2%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI--ANEVSPRF 61 DLS+T G+KFPNPF + S P G Y + KA+D GWGGV+ KT+ V+PR+ Sbjct: 62 PDLSVTVNGLKFPNPFVIGSGPPGTNYTVMKKAFDEGWGGVIAKTVSLNADLVKNVTPRY 121 Query: 62 DHLV-KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQQWEEL 119 + ++ +G++N+E I++ E LA ++LKE+YPD++LIASIM E ++ W E+ Sbjct: 122 AKMKSEDGAEVLGWQNIELISDRSFEVMLAEFKQLKEEYPDRILIASIMDEYKKENWVEV 181 Query: 120 ARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R +E G D E NFSCP M MG+ +GQ ++++ C VK +T+P+ AKMTPN Sbjct: 182 VRRCEEVGVDAFEINFSCPHGMPERKMGAAMGQDCTVLDEVCGWVKEVATVPVWAKMTPN 241 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 I D+ E A G DGIAAINT+ SI ++L+ P V G S+ GYS KAV+PIA Sbjct: 242 ITDITEPANVCLEKGMDGIAAINTIMSIMGVNLDTLAPEPCVEGHSTPGGYSYKAVRPIA 301 Query: 239 LRFIQQMRT--HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 L + E D +SGIGGI+T AAEF+LLG+ T+QV TG+M +GY +V+++ Sbjct: 302 LAKCMAIAQMIKKEFPDRTLSGIGGIDTGGHAAEFILLGSDTVQVCTGVMIHGYPLVQNL 361 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVPAED 328 + L ++ GF+S+ E G++ D Sbjct: 362 CAELQEFMGKHGFESIAEFKGMSLEYFTTHTD 393 >UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39 Tax=cellular organisms RepID=PYRD_HUMAN Length = 395 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 131/328 (39%), Gaps = 23/328 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L + G KF NP +++ + E Y G+G V ++ PR L Sbjct: 78 LEVRVLGHKFRNPVGIAAGFDKHG-EAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRL 136 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLA-ALRRLKEDYPDKVLIASIMGENE---QQWEELA 120 + D I +E L ++ + D + + +G+N+ E+ A Sbjct: 137 PE-DQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYA 195 Query: 121 RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPMLAKM 175 V+ G AD + N S P + L+ K + ++R +L K+ Sbjct: 196 EGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKI 255 Query: 176 TPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D ++A K G DG+ NT S +S G SGK Sbjct: 256 APDLTSQDKEDIASVVKELGIDGLIVTNTTVSRP--------AGLQGALRSETGGLSGKP 307 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 ++ ++ + I++M + PI G+GG+ + +DA E + GA+ +Q+ T + +G +V Sbjct: 308 LRDLSTQTIREMYALTQ-GRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVV 366 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANN 321 + L L +QGF + + +G + Sbjct: 367 GKVKRELEALLKEQGFGGVTDAIGADHR 394 >UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria RepID=PYRD_HELMI Length = 309 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 89/324 (27%), Positives = 145/324 (44%), Gaps = 20/324 (6%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 M + +L + G+ NP +S G E + G +V K +P Sbjct: 1 MGSLNLQVNLGGLTMKNPVTTASGTFGFGLEFAPFIDLSRLGAIVVKGTTLEPREGNPTP 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R IG +N E + + L LR++ D +I ++ G + + + L Sbjct: 61 RMAETPAGMLNAIGLQNPGV--EAFIRDYLPPLRQI-----DTPVIVNVSGNSVEDYGRL 113 Query: 120 ARLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A ++ EA G +E N SCP + G G P RAV+ + P++ K++PN Sbjct: 114 ASILDEADGVAALEVNISCPNVKEG--GIQFGTLPASAAAVTRAVRENTQKPVIVKLSPN 171 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ E+A A GAD +A INT+ + D++ P++ + G SG A+KP+A Sbjct: 172 VTDITEMARAVVDAGADALALINTLLGM---DIDICTRRPVL--ANIFGGLSGPAIKPVA 226 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR I Q+ PI G+GGI +DA F+L GA + V T R D+ Sbjct: 227 LRMIYQVYRAV---HVPILGMGGIMNSQDAIAFMLAGATAIAVGTANFTN-PRATMDILE 282 Query: 299 GLSHYLADQGFDSLQEMVGLANNN 322 G+ Y +G + E++G A+++ Sbjct: 283 GIEEYCCREGVRDVNELIGAAHSH 306 >UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular organisms RepID=Q5PR57_DANRE Length = 407 Score = 251 bits (641), Expect = 3e-65, Method: Composition-based stats. Identities = 72/337 (21%), Positives = 131/337 (38%), Gaps = 25/337 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L + G KF NP +++ + E Y G+G V T+ PR Sbjct: 74 PTSLEVHVMGRKFQNPVGMAAGFDKHG-EAVDGLYRLGFGFVEVGTVTPKPQDGNPKPRV 132 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP--DKVLIASIMGEN---EQQW 116 L + D I + E L A ++ + K L ++ G+N Sbjct: 133 FRL-ESDQAVINRYGFNSCGLSAVHERLKAREHVQSELTKAGKPLGINL-GKNKLSPDAV 190 Query: 117 EELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPM 171 + V+ G AD + N S P + L++K + ++ + P+ Sbjct: 191 SDYVEGVRTLGPLADYLVVNVSSPNTPGLRDLQGKEELRHLLDKVVKERDSLRIENRPPV 250 Query: 172 LAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 L K+ P++ D ++A G DG+ NT S + + + G Sbjct: 251 LVKIAPDLTTQDKQDIAEVIMEVGVDGVMVSNTTVSRPDTLKD--------PNRVETGGL 302 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG+ +K ++ + +++M T + PI G+GG+ + +DA + + GA+ +Q+ T ++ G Sbjct: 303 SGQPLKELSTQTVREMYTLTQ-GKLPIVGVGGVASGQDAMDKIRAGASLVQLYTALVYQG 361 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPA 326 +V + L L QGF + E VG + Sbjct: 362 PPVVNKIKRELDDLLKAQGFTCVAEAVGADHKTTEKM 398 >UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-cluster domain n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E020_METI4 Length = 387 Score = 250 bits (639), Expect = 6e-65, Method: Composition-based stats. Identities = 139/362 (38%), Positives = 211/362 (58%), Gaps = 13/362 (3%) Query: 56 EVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE-NEQ 114 VS R+ K D +G N+E I++ PL NL ++ +K +P++ LI S+M E + + Sbjct: 3 NVSNRYAVYKKGDR-ILGMNNLELISDRPLSVNLKEIQEVKRLWPNRALIVSMMEEYDRK 61 Query: 115 QWEELARLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 +WEELA+ ++ +GAD IE NF CP M GS +GQ P + V+R ++LP++ Sbjct: 62 KWEELAQKIEGSGADGIELNFGCPHGMPERGTGSKIGQDPARCAEVTSWVRRVTSLPLIV 121 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K+TPN+ D+ +A AA GGA ++ INT++SI +D++ +P + GKSS SGYSG+A Sbjct: 122 KLTPNVTDISCIARAAIAGGASALSLINTLESILGVDIDTFEVLPSIAGKSSHSGYSGEA 181 Query: 234 VKPIALRFIQQMR--THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 +KPIAL ++ + + IS +GGI +W D EFLLLGA +LQ+ T +M G+R Sbjct: 182 IKPIALNLTAKVASMEEVQKKGLAISAMGGISSWRDGVEFLLLGATSLQLCTSVMLKGFR 241 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCY 351 I ED+ SGL +++ +GF S+ E G + +++VP LD + +IN KC+ C CY Sbjct: 242 IAEDLLSGLKNWMRSKGFRSIAEFRGKSLSHLVPFSKLDPLFKEVAKINPQKCIRCLLCY 301 Query: 352 ISCYDGGHQAMEWSEK-------TRTPHCNTEKCVGCLLCGHVCPVG-CIELGEVKFKKG 403 + C D +Q +E K PH CVGC LC H+CPV CIE+ + ++ Sbjct: 302 VGCRDSAYQCIEVDNKLDLFSNPVNYPHVREADCVGCSLCRHLCPVDSCIEMIPAQAEEN 361 Query: 404 EK 405 Sbjct: 362 RP 363 >UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14 Tax=Drosophila RepID=PYRD_DROME Length = 405 Score = 249 bits (635), Expect = 2e-64, Method: Composition-based stats. Identities = 76/332 (22%), Positives = 133/332 (40%), Gaps = 27/332 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 +L +F G NP +++ N E D G+G + T+ PR Sbjct: 85 NLHTSFFGRMLSNPIGIAAGFDKN-AEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFR 143 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW---EELA 120 L ED I + L LR L++ ++ +G N+ + Sbjct: 144 L-TEDKAIINRYGFNSDGHQAV---LQRLRLLRKKENFNGVVGVNLGRNKTTMSPIADYV 199 Query: 121 RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKY---CRAVKRGSTLPMLAKM 175 + V+ G AD + N S P + EL+E+ ++ + +P+L K+ Sbjct: 200 QGVRVFGPVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLDKNKNVPILLKL 259 Query: 176 TPNI--GDMCEVALAAK--RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 +P++ DM ++ K + DG+ NT S NI+ N+ G SG Sbjct: 260 SPDLSLDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKLAE--------ETGGLSG 311 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 +K + I QM PI G+GG+ + DA E + GA+ +Q+ T ++ G Sbjct: 312 PPLKARSTEMIAQMYQLT-DGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPA 370 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 +VED+ + LS + G ++ ++VG + Sbjct: 371 LVEDIKAELSALITRLGHTNVADVVGTNSKFY 402 >UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organisms RepID=Q7PYN9_ANOGA Length = 404 Score = 246 bits (627), Expect = 1e-63, Method: Composition-based stats. Identities = 67/323 (20%), Positives = 118/323 (36%), Gaps = 25/323 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L G+ F NP +++ + E G+G V ++ PR Sbjct: 83 RLRTRLLGMAFSNPIGIAAGFDKHG-EAVQGLQLIGFGFVEIGSVTPEPQPGNARPRIFR 141 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEELA 120 L ++ + + E L R ++ +V + +G+N+ + Sbjct: 142 LNEDKA-IVNRYGFNSEGHDVVYERLRECRE-QQPPDQRVALGINLGKNKLSLDAIADYV 199 Query: 121 RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPMLAKM 175 + V+ G AD + N S P L+ + +A + P+L K+ Sbjct: 200 QGVKRFGTLADYLVINVSSPNTPGLRTMQSKSTLQTLLTEVLKARASLPANEQRPILLKL 259 Query: 176 TPNIG--DMCEVALA--AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 P++ D+ E+ AK DG+ NT + G SG Sbjct: 260 APDLSEEDLREIVDVVRAKACAVDGLIVSNTTIDRP--------ATLRSVNAGQLGGLSG 311 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 +K + I ++ E PI G+GGI T EDA E + GA+ +Q+ T + +G Sbjct: 312 PPLKHRSTAMIARVYKLTE-GKIPIIGVGGIFTGEDAFEKIEAGASAVQLYTSFIFHGPP 370 Query: 292 IVEDMASGLSHYLADQGFDSLQE 314 +V + L L G+ S+Q+ Sbjct: 371 VVPKIKRELDRLLEANGYASVQD 393 >UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=C0Z506_BREBN Length = 363 Score = 245 bits (626), Expect = 2e-63, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 121/328 (36%), Gaps = 36/328 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 L G+ FPNP L++ N E+ G+G V T+ PR Sbjct: 48 RLENKLWGMTFPNPVGLAAGFDKN-AEVYHALGALGFGFVEIGTLTPQGQPGNPKPRLFR 106 Query: 64 LVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQW 116 L + +GF N LA+ + Y D I +G+N+ + Sbjct: 107 LPEHQAVINRMGFNNHG--------AYLASQHLVDYAYSDVP-IGINIGKNKVTPNEEAA 157 Query: 117 EELARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----KRGSTL 169 + ++ + A N S P + + LV + Sbjct: 158 VDYSKCMDMLYAYGHYFVINISSPNTPNLRDLQETESLRHLVRAVKEKATEMEGRSIKKK 217 Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+L K+ P++ D M +V AA G GI A NT S + ++ Sbjct: 218 PILLKVAPDMSDEHMRDVVHAAVEEGISGIIATNTTLSREAVSGHRFAE--------EAG 269 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ + + +++++ + PI G+GGI EDA + GA+ +QV TG++ Sbjct: 270 GLSGRPLTERSTAWVKEIYQEVGDK-VPIIGVGGIYNGEDAYAKIRAGASLVQVYTGMIY 328 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEM 315 G I + + L + GF + E+ Sbjct: 329 QGPGIAKQINKKLLKLMQRDGFKHISEV 356 >UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium carboxidivorans P7 RepID=C6Q0J2_9CLOT Length = 360 Score = 244 bits (623), Expect = 4e-63, Method: Composition-based stats. Identities = 99/393 (25%), Positives = 172/393 (43%), Gaps = 33/393 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 +L++ G+K NP +S P + + G G +V KTI P Sbjct: 1 MANLNVDLHGIKIKNPIMPASGPQVRNADCMLECVKQGVGALVTKTISEKFVRTARPCMQ 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 F N E +E +E+ + + Y I S+ G ++ E++ + Sbjct: 61 ETKDG-----AFLNSELWSELSVEQWVEKGYSKCKSY-GVPFIVSL-GYTAKEIEKVLPI 113 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + AD+IE + + E V + + S P+ K++P I + Sbjct: 114 ITPY-ADIIEI-----------STHYMEKDLESVVDSLK-IASKSDKPVYIKISPGITKI 160 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 GA G AIN++ +ID+ G+P + G+ SGK++ PIALR++ Sbjct: 161 GWYVKRLVEEGAAGFVAINSLGPCLHIDVE--TGLPYLGGEKGYGWLSGKSLNPIALRYV 218 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + P+ G+GGI + EDA ++ GA+ +Q+ T + G + +++ L+ Sbjct: 219 YSIANSVK---VPVIGVGGISSGEDAVAMIMAGASAVQICTAAILEGNGVYSRVSNELNS 275 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAM 362 +L GF+S++++ GL + + + P+IN +KC CG+C SC + A+ Sbjct: 276 WLDAHGFESVEDIRGLTARKMQERKVIREPIF--PKINKEKCNSCGKCVKSC---AYSAI 330 Query: 363 EWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 S+K + NT KC GC LC CP IE+ Sbjct: 331 TISDK---ANINTTKCFGCGLCLTRCPETAIEV 360 >UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (Dhodehase) (Dhodase) (Dhod) n=3 Tax=Hydrogenothermaceae RepID=C0QU30_PERMH Length = 320 Score = 243 bits (619), Expect = 1e-62, Method: Composition-based stats. Identities = 93/319 (29%), Positives = 153/319 (47%), Gaps = 19/319 (5%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYD-TGWGGVVFKTIGFFIA-NEVSPRFDH 63 LS G+KF NP +S E+ YD + G VV K + + R Sbjct: 12 LSYELFGIKFKNPVWTASGCFSYGLEVAQNLYDISELGAVVVKGLSYRPREGNPPQRIVE 71 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 IG +N E+ ++ L LR D V++A++ GE+E ++ ++A ++ Sbjct: 72 TPCGMLNSIGLQNPGV--EYFIKNILPQLREY-----DTVIVANVFGEDEDEYLKVAEVL 124 Query: 124 QEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 +A G D++E N SCP + G G PE + +K+ P+L K++PNI D+ Sbjct: 125 NKADGVDLLELNVSCPNVKKG--GIAFGSDPETLFNLVYRLKQVMEKPLLVKLSPNITDI 182 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + A A+ GADG+ INT+ + ++ PI+ ++ G SG A+ P+A+R I Sbjct: 183 LDTATASVEAGADGLVLINTLLGMA---IDIDKEEPIIGMRT--GGLSGPAILPVAVRMI 237 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 Q+ PI G+GGI T +DA + +L GA ++Q+ T Y + GL Sbjct: 238 YQVYEKYGS-SVPIIGVGGITTAQDALQHILAGAVSVQIGTANF-YDPYSPLKVIKGLKE 295 Query: 303 YLADQGFDSLQEMVGLANN 321 +L +G+D ++VG A+ Sbjct: 296 HLDKKGYDHFLQLVGKAHK 314 >UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydrogenase n=1 Tax=Sulfolobus tokodaii RepID=Q972L2_SULTO Length = 350 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 120/343 (34%), Positives = 183/343 (53%), Gaps = 6/343 (1%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS+TF G+ FPNPF + S P A GWGGVV KTIG I + Sbjct: 1 MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMY 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDK-VLIASIMG-ENEQQWEELA 120 ++ + I F+N+E I E PLE LR +K + +I SIMG + +W LA Sbjct: 61 ATIRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYSEWIRLA 120 Query: 121 RLVQEAGADMIECNFSCPQ-MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 R ++ GADM+E NF CP G+ +GQ +LV++Y + V +P++AK+TPNI Sbjct: 121 RWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEYTKEVVSSVGIPVIAKLTPNI 180 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E A AA+ GA + AINTV + +D+ + +P +NG S G SG AVKPI L Sbjct: 181 TDIRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGGISGPAVKPIGL 240 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + ++ T ISG+GGI W DA E++++GA T+Q T + G+ + + Sbjct: 241 AAVSKIYTST---SLQISGVGGIFDWRDAVEYIMMGATTVQSVTYTILKGFEFINEWKKE 297 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLD 342 L ++ +G+ ++++M GLA + E L++ ++ + Sbjct: 298 LESFMERKGYRAIEDMRGLAAKKMTTYEVLEKVTKRRTSVDEE 340 >UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales RepID=PYRD_SULSY Length = 311 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 82/322 (25%), Positives = 147/322 (45%), Gaps = 18/322 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L T G++F NP +S E+ + G +V K + + R Sbjct: 1 MDKLKHTLFGLEFKNPVWTASGTFSYGLEVAKIYDLSLLGAIVVKGLSLKPRKGNMPERI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG +N ++ + E L L++ D + A++ GE+E ++ +A Sbjct: 61 VETPAGMLNSIGLQNPGV--DYFINETLPKLKKY-----DTKIFANVFGEDEDEYLAVAE 113 Query: 122 LVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + +A G +E N SCP + G G PE++ +K+ + P+L K++PN+ Sbjct: 114 RLDKADGVHGLELNVSCPNVKKG--GIAFGTDPEVLYNLVYKMKKITKKPLLVKLSPNVS 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++ + A A GADG+ INT+ + ++ + PI++ + G SG A+ PIA+R Sbjct: 172 NILDTADACVSAGADGLVLINTLLG---VAIDVEREKPILS--TITGGLSGPAMLPIAVR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 I Q+ PI G+GGI ++DA + +L GA+ +QV T Y + L Sbjct: 227 MIWQVYQKYGS-RIPIIGVGGISNYKDALQHILAGASAIQVGTANF-YDPLSPLKIIEDL 284 Query: 301 SHYLADQGFDSLQEMVGLANNN 322 ++L +G+ +++G A+ Sbjct: 285 KNHLDKKGYVHYSQLIGKAHQM 306 >UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota RepID=Q75XR0_EUGGR Length = 435 Score = 241 bits (616), Expect = 3e-62, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 130/352 (36%), Gaps = 36/352 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DL + G+KF NP L++ + E TG+G V T+ SPR Sbjct: 95 PADLEMEVWGLKFSNPLGLAAGFDKHG-EAVDALLGTGFGFVEIGTVTPLPQPGNPSPRM 153 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQWEE 118 L ++D I + + L R P L+ +G+N+ + Sbjct: 154 FRL-EQDRAIINRYGFNSQGLAAVRKRLE--ARQHRPAPRGGLVGVNVGKNKLQEDAAAD 210 Query: 119 LARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVE-------KYCR-------- 161 ++ ++E G AD + N S P +L++ + R Sbjct: 211 YSKGLRELGPYADYLVINVSSPNTPGLRNLQKRSAMADLIKASMVARDEVVRDADGRRAA 270 Query: 162 AVKRGSTLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 A K + LP+L K+ P++ + ++A DG+ NT S L+ Sbjct: 271 AGKSAAPLPLLIKIAPDLTAEEKQDIAEVVMETKIDGLIVSNTTVSRPASLLS------- 323 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 K G SG ++ ++ + I+ M PI G+GG+ T ED E L GA+ + Sbjct: 324 -PHKGQTGGLSGAPLREMSTQAIRDMYALTR-GTVPIVGVGGVATGEDVLEKLKAGASLV 381 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331 Q+ + ++ G + GL L + F S + VG + A Sbjct: 382 QMYSMLVYDGPGAPPRVKKGLLQALRREHFGSARSAVGADHRGQPWAPSPTP 433 >UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchaeota RepID=PYRD_METTH Length = 303 Score = 240 bits (612), Expect = 8e-62, Method: Composition-based stats. Identities = 99/316 (31%), Positives = 154/316 (48%), Gaps = 17/316 (5%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L + C ++ NP L++ +G+ + Y G G VV K+ R V Sbjct: 5 LETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRP--NPGYRNPTTV 62 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 + G I + E L + + LIAS+ G + +++ A V+E Sbjct: 63 EVTGGVINAIGLSNPGVEAFREELKLVDE------EVPLIASVYGASPEEFASAAASVEE 116 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 ADMIE N SCP G+ +GQ PEL + AVK +P+ K+TPN+ D+ E+ Sbjct: 117 Y-ADMIELNVSCPH-AMAGCGASIGQDPELTFRVVSAVKDAVDVPISTKLTPNVTDIVEI 174 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A +A+ G+D + IN++ ID+ PI++ G SG A+KP+A+R + + Sbjct: 175 AGSAEEAGSDALTLINSLGPGMKIDIK--TARPILSNA--FGGMSGPAIKPVAVRCVYDV 230 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 D PI G+GG+ ++DA EFL GA +QV T IM G + + GL ++ Sbjct: 231 YRSV---DIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGLEAFMM 287 Query: 306 DQGFDSLQEMVGLANN 321 +GF S+ EMVGLA++ Sbjct: 288 AEGFSSVDEMVGLAHD 303 >UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria RepID=PYRD_GEOTN Length = 313 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 87/319 (27%), Positives = 140/319 (43%), Gaps = 20/319 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L++ G+ NP +S G E + G ++ K +PR Sbjct: 1 MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRV 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG +N + L E L L + D +IA+I G +++ E+A Sbjct: 61 AETPSGMLNAIGLQNPGL--DKVLAEELPWLEQF-----DVPIIANIAGSTMEEYVEVAA 113 Query: 122 LVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + +A +E N SCP + G G PE+ + R VK S +P+ K++PN+ Sbjct: 114 AISKAPNVHALELNISCPNVKKG--GIAFGTVPEVAAELTRLVKEVSAVPVYVKLSPNVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ +A A ++ GADG+ INT+ + ++ K G PI+ + G SG AVKPIA+R Sbjct: 172 DIVAMAKAIEQAGADGLTMINTLVGMR---IDVKTGRPIL--ANGTGGLSGPAVKPIAVR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 I ++ PI G+GG++T ED EF GA+ + V T + + + L Sbjct: 227 MIYEVSQAV---SIPIIGMGGVQTAEDVLEFFYAGASAVAVGTANFI-DPFVCPTIINEL 282 Query: 301 SHYLADQGFDSLQEMVGLA 319 L + G + E G + Sbjct: 283 PVLLDELGIRHISECTGRS 301 >UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 Tax=Thaumarchaeota RepID=A9A3M4_NITMS Length = 303 Score = 238 bits (607), Expect = 3e-61, Method: Composition-based stats. Identities = 87/321 (27%), Positives = 154/321 (47%), Gaps = 20/321 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + +L+ + ++ P L+S +G ++ ++ Y +G G VV K++ +P Sbjct: 1 MEPNLATSIGPIQLDRPVMLASGILGISLDVFSRLYRSGAGAVVTKSLSTEPWEGYPNPT 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + G+ N ++ E + E D +I S++G + +E++ Sbjct: 61 IFSVKGG-----GWINAVGLSNPGAENFAKMI----EPNQDVPIIVSLVGSIPEDFEKMI 111 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + + E N SCP + +G +VG PELV+K VK + +P++AK+ Sbjct: 112 KQFENCKVTAYELNLSCPHVAK--VGLEVGDDPELVKKIVTTVKNSTNVPVIAKVGLGTT 169 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 A G D I AINTV+S+ ++ + PI++ K G SG +KPIALR Sbjct: 170 HYLNTVGTAIESGIDAITAINTVRSMA---IDVETQRPILSNK--FGGLSGTPIKPIALR 224 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ + D PI G GGI TWEDA EF L GA+++Q+ + I + ++ +G+ Sbjct: 225 CVYEISSKY---DIPIIGCGGISTWEDAVEFFLAGASSVQLGSAIGDNWIDVFNEINTGI 281 Query: 301 SHYLADQGFDSLQEMVGLANN 321 Y+ + + ++EM+GLA Sbjct: 282 LQYMEKKNYSKIEEMIGLAKK 302 >UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasmatales RepID=PYRD_THEVO Length = 301 Score = 238 bits (606), Expect = 4e-61, Method: Composition-based stats. Identities = 90/318 (28%), Positives = 160/318 (50%), Gaps = 21/318 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 D+S T G+K NPF ++S + + + G VV K+IG +P Sbjct: 1 MSDISTTLAGIKLVNPFMVASGILDENGYTMKELLERGAAAVVTKSIGISERDGYPTPVI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 +G N +E + KE + +I S+ N +++ +L+ Sbjct: 61 VEYGDSLINAVGLSNP------GIENFGEEINIAKEAK--RPIIGSVFAYNAEEFTKLSV 112 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++E G D IE N SCP + G +VG P+LVE +K +P+ AK++PN+ + Sbjct: 113 KMEEYGVDAIELNLSCPHVKG--FGLEVGSDPDLVEDIVNEIKSKVKVPVFAKLSPNVSN 170 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+A AA++ AD INTVK++ ID+ + + + G SG A+KP+ +R+ Sbjct: 171 IIEIAKAAEK--ADAYVLINTVKAMA-IDIYSRSPVLS----NLYGGLSGPAIKPVGIRY 223 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + +++ I G+GGI ++DA E+++ GA+ +Q+ T + +YG I +M L Sbjct: 224 VYEVKKETGKE---IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYGKGIFREMEWQLR 280 Query: 302 HYLADQGFDSLQEMVGLA 319 ++ ++ F+ ++EMVG+A Sbjct: 281 TFMDEERFEKIEEMVGVA 298 >UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0P959_9FIRM Length = 371 Score = 237 bits (605), Expect = 4e-61, Method: Composition-based stats. Identities = 95/391 (24%), Positives = 166/391 (42%), Gaps = 24/391 (6%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKE 67 I+F G+ NP +++ P K D G V+ +TI SPR + E Sbjct: 5 ISFMGLALKNPLIVAAGPWSGGAAAIQKCIDAGAAAVITETIVMEEPWLFSPRIYYHDDE 64 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 N+ + LEE + R+++D LI SI + + +A+ + G Sbjct: 65 ------LLNLSLYGKRTLEEWEGEVERVRKDSCH--LICSIRASSPSEIAYIAQRTERLG 116 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 AD ++ + P +M D+ PE + ++ A ++P++ ++ N+ Sbjct: 117 ADALQLDLYAPM---DSMIEDIHLQPEKLYEFVHAAASAVSIPVMTRLPYNLAASAPHLH 173 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 A +R G I AI ++++++ +DL + + + GY+G+ ++PI+L + Sbjct: 174 AVERAGLRAICAIESLRALSGVDLETQTTLMP-----TYGGYTGRHIRPISLAATATLAQ 228 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 D PI G+GG+E + EF++LGAA Q+ + IM +GY ++ L ++ Sbjct: 229 LT---DLPICGVGGVEDYRSILEFIMLGAAAAQLGSAIMLHGYDLITKTVRALEDWMQAH 285 Query: 308 GFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK 367 G+D + G A +++ P E V GCG C C G + Sbjct: 286 GYDDYSSITGAALSSLTPFEKAVHRRAVCRMTQPCSRTGCGLCTCGCMYGA-----LVME 340 Query: 368 TRTPHCNTEKCVGCLLCGHVCPVGCIELGEV 398 H N+ +C GC LC CP G L Sbjct: 341 PDGVHLNSSQCTGCGLCVQRCPQGLFHLETF 371 >UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomus RepID=B5YFH3_DICT6 Length = 306 Score = 235 bits (600), Expect = 2e-60, Method: Composition-based stats. Identities = 84/311 (27%), Positives = 136/311 (43%), Gaps = 19/311 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 +L + + F NP L+S GN E+ G GG V K+I PR Sbjct: 1 MNNLEVRIGSLIFKNPILLASGTCGNGREINKFYDINGLGGFVTKSITLNPREGNPPPRI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG +N+ + LEE + L RL + +I SI GE ++++ E+AR Sbjct: 61 WESYAGILNSIGLENVGL--QKFLEEEMPFLERLSTN-----VIVSIAGEKKEEYYEIAR 113 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ +E N SCP + M G E+V++ + V + P+ K+TP D Sbjct: 114 NLRGCKISGVELNLSCPNVEGGGML--FGIDKEMVKEITKKVVKEIGKPVWVKLTPQAKD 171 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+ A K G + + NT + ID ++ + K +GYSG AVKP+ LR+ Sbjct: 172 IVEIVKAVKDAGGEAVVLFNTFLGLA-IDWKKRKPV----FKRIFAGYSGPAVKPLVLRY 226 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + ++ E PI G GGI ++ D E++ GA+ +Q+ + I E + Sbjct: 227 VWEVY---EENLLPIVGCGGIVSFSDVLEYIFAGASLVQIGSANF-RDPWIGERLVKEAF 282 Query: 302 HYLADQGFDSL 312 Y + L Sbjct: 283 KYFEKERVMDL 293 >UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9KKE5_9FIRM Length = 316 Score = 234 bits (598), Expect = 4e-60, Method: Composition-based stats. Identities = 94/332 (28%), Positives = 146/332 (43%), Gaps = 19/332 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 M + L G+ P +S G E + GGV+ K Sbjct: 1 MSDERLHTNLLGIAMQTPVLTASGTFGFGEEFADFVDLSRLGGVMVKGTTLLPRRGNDGV 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R K IG +N EH L+E L +++ +I +I G + + +L Sbjct: 61 RITETPKGMLNCIGLENPGV--EHFLKETLPRIQQY-----GMNVIVNISGSTAEDYGKL 113 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 A L+ G IE N SCP + G G PE RA K + P++ K++PN+ Sbjct: 114 AGLLDVPGVAAIELNVSCPNVKEG--GIVFGTDPEAASAVVRAAKAHTKKPVILKLSPNV 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ +A A + GAD ++ INT+ + +++ P++ + G SG VKP+A+ Sbjct: 172 TDIVAMAKAVEAAGADAVSLINTLLGM---EIDIHRFRPVLGNIT--GGLSGPCVKPVAV 226 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ PI G+GGI + EDA EF L GA+ + V T I + G Sbjct: 227 RMVWQVAQAV---HIPIIGMGGIASAEDAVEFFLAGASAVAVGTANFT-DPEITMKICDG 282 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331 L+ YLA+ GF S++E+VG AN + + Sbjct: 283 LTDYLAENGFSSIEEIVGKANPGFLGFPKDVQ 314 >UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaproteobacteria RepID=PYRD_AGRT5 Length = 363 Score = 234 bits (597), Expect = 4e-60, Method: Composition-based stats. Identities = 66/338 (19%), Positives = 128/338 (37%), Gaps = 33/338 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L T G+ FPNP +++ N E+ G+G T+ PR Sbjct: 43 PRLQQTVAGLVFPNPLGMAAGYDKN-AEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIF 101 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGE--NEQQWEE 118 LV+++ +GF N A L RL + ++ +I +E + + Sbjct: 102 RLVEDEGVINRLGFNNEGHAAA---------LERLTQARLRGIVGVNIGANKDSEDRIAD 152 Query: 119 LARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGSTLPM 171 + ++ A N S P L+ A + G +P+ Sbjct: 153 YVQGIEAFYAVASYFTVNISSPNTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIPI 212 Query: 172 LAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ + + +VA A DG+ NT S + + G Sbjct: 213 FLKIAPDLTEEGLDDVAEEALAHDLDGLIVSNTTLSREGLRPG--------PHRGEAGGL 264 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + ++ + +MR + PI G+GG+ + E A E + GA +Q+ + ++ G Sbjct: 265 SGKPLFELSTTVLAKMRRRVGA-NLPIIGVGGVSSAETALEKVRAGADLVQLYSCMVYEG 323 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 + + G+S +A +G ++++++ A + + Sbjct: 324 PGLPSAIVKGMSKLVAREGVETIRDLRDSAVDRWADRK 361 >UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit n=5 Tax=Clostridium difficile RepID=C9XJU2_CLODC Length = 361 Score = 234 bits (596), Expect = 5e-60, Method: Composition-based stats. Identities = 93/386 (24%), Positives = 163/386 (42%), Gaps = 39/386 (10%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 F G + +P + S P+ C D G G VV KTI A +P H+V+ Sbjct: 3 NFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIRKERAINPAP---HMVRNT 59 Query: 69 TGFIGFKNMEQIAEHPLEENLA-ALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 N E+ + E+ + + ++K D V IAS+ G ++ EL V AG Sbjct: 60 ANA--LLNNEKWTDFEPEQWIDFEIPQMKRD--GTVCIASV-GHTIEESSELVEKVANAG 114 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVAL 187 AD IE V + + K +P++ K+ P I ++ + A Sbjct: 115 ADFIEL---------------VSYDYRDLIPMLKDAKERVNIPVIVKLPPMIDEIGDFAK 159 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 + GAD I A ++V ID+ + G + I SG+ +KPI L+ I +++ Sbjct: 160 KLEEAGADAITACDSVGPAFRIDIETGQP---LLGGNGIGYLSGETIKPITLQRIYEIKK 216 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQ 307 + PI G+GG + +DA E ++ GA + + + ++ G +++ + L L Sbjct: 217 QV---NIPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDLKSNLNRL 273 Query: 308 GFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEK 367 G+++++ G+ +N++ + +KC C C C +QA + ++K Sbjct: 274 GYNTIENACGIVHNHMGDVN---ERLSFEFTYDEEKCTKCKMCERVC---AYQARKLNDK 327 Query: 368 TRTPHCNTEKCVGCLLCGHVCPVGCI 393 N E+C C LC VC + Sbjct: 328 M---ELNEEECRYCGLCISVCKPKAL 350 >UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_THEYD Length = 303 Score = 234 bits (596), Expect = 6e-60, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 141/315 (44%), Gaps = 20/315 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 L + + F NP +S G E GG+V K + PR Sbjct: 1 MPVLEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG +N+ E +E L L++ + +I + GEN ++ E+A+ Sbjct: 61 YETPCGMINSIGLQNIGL--EAFKKEKLPFLKKFNTN-----IIVNFFGENLDEYIEVAK 113 Query: 122 LVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 L+ E G +E N SCP + +G PEL+ + + V+ P++ K+ P + Sbjct: 114 LLDETEGVHALEMNVSCPN--KTSEWRKMGLEPELLREAIKRVRLHIKKPLIVKLAPQVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++ +A + GAD ++ INT+ ++ ID+ + M + G SG A++P+ALR Sbjct: 172 EIALMARICEEEGADAVSLINTIPAMV-IDIKTRKSMIG----TLTGGLSGPAIRPVALR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ + P+ G+GGI + EDA +FL+ GA +QV T V ++ G+ Sbjct: 227 AVWEVAQAVK---IPVIGVGGIVSAEDALQFLIAGAKAIQVGTANFINPIATV-EIIEGI 282 Query: 301 SHYLADQGFDSLQEM 315 +L ++ + E+ Sbjct: 283 KQFLIEENIKDINEI 297 >UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 Tax=Saccharomycetales RepID=PYRD_ASHGO Length = 444 Score = 233 bits (595), Expect = 8e-60, Method: Composition-based stats. Identities = 67/347 (19%), Positives = 124/347 (35%), Gaps = 37/347 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFD 62 L + G NP ++ + E +G+G V T+ PRF Sbjct: 105 PVLKVEVFGKTMSNPIGCAAGLDKDG-EAIDGIAQSGFGYVEIGTVTPLAQPGNPKPRFF 163 Query: 63 HLVKEDT--GFIGFKNMEQ--------------IAEHPLEENLAALRRLKEDYPDKVLIA 106 L ++ GF + + + ++ + +L K+ L Sbjct: 164 RLPMDEAVINRYGFNSSGHKKVYDNVLSRVRQFLGAYFRDDTVNSLALYKDKLLGINLGK 223 Query: 107 SIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG 166 + G+ + + Q AD++ N S P G+ EL+ Sbjct: 224 NKNGDEVEDYLRGVEKFQSL-ADVLVINVSSPNTPGLRDLQQEGRLTELLSMIVAKRNSL 282 Query: 167 ST-----------LPMLAKMTPNIGDMC--EVALAAKRGGADGIAAINTVKSITNIDLNQ 213 P+L K+ P++ + +A AAK+ DGI NT + Sbjct: 283 INEGNVLGASTHKPPVLVKIAPDLTEPELQSIAEAAKKSSIDGIIVSNTTIQRPDSLYTV 342 Query: 214 KIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLL 273 + K+ G SGK VKP AL+ ++ + + + + + G GGI + +DA EF Sbjct: 343 DEEL-----KNQAGGLSGKPVKPFALKALRTIHQYTKDTNLVLVGCGGISSGQDAIEFAK 397 Query: 274 LGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 GA +Q+ T G ++ + ++ L ++G ++ + A Sbjct: 398 AGAHFVQLYTAYAYRGPGLIARIKDEVTEELRNEGKTWMEIIGQDAK 444 >UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 Tax=Dekkera bruxellensis RepID=A2VBP6_DEKBR Length = 442 Score = 233 bits (594), Expect = 9e-60, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 118/322 (36%), Gaps = 33/322 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L + G NP +++ E YD G+G V TI PRF L Sbjct: 109 LRVDLFGRTLANPIGMAAGFDK-QAEAMDALYDLGFGIVEVGTITPEPQFGNPRPRFFRL 167 Query: 65 VKEDT--GFIGFKNMEQIAEHP-----LEENLAALRRLKEDYP---DKVLIASI----MG 110 ++T G + ++ LE+ L K + K L +I G Sbjct: 168 NADETVINRYGLNSDGRLTILSRLRVRLEKYLKKSNACKTNNSFREGKSLFVNIGKNRNG 227 Query: 111 ENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR----- 165 + + AD + N SCP + EL+ K + Sbjct: 228 DTIDDYLVGVDTFAPY-ADALVLNVSCPSAPGVRDLQEKDVLLELLTKVREERDKVGANV 286 Query: 166 ---GSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 P++ K+ P++ + + ++A AK+ DGI NT + + + + Sbjct: 287 IDPARKPPIIVKVAPDLSEKEIADIADVAKKSKIDGILMSNTTTARPASLITKGPVVQ-- 344 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQ 280 G SG+A++ I+L+ + +R + + D + G GGI T +DA F GA+ ++ Sbjct: 345 ----EKGGLSGRAMRDISLKAFRTLRKYTKDSDLVLIGCGGIFTGKDAIAFAKAGASAIE 400 Query: 281 VTTGIMQYGYRIVEDMASGLSH 302 + T G I + + + Sbjct: 401 LYTSFAYRGPGIPDKIKDEIVQ 422 >UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Culicini RepID=B0W4C3_CULQU Length = 397 Score = 233 bits (594), Expect = 1e-59, Method: Composition-based stats. Identities = 63/327 (19%), Positives = 125/327 (38%), Gaps = 31/327 (9%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 + L NP +++ + E G+G V ++ PR Sbjct: 77 PEVLRTQLLNKTLENPVGIAAGFDKHG-EAVKGLERLGFGFVEIGSVTPEPQPGNPKPRV 135 Query: 62 DHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---QQW 116 L ++ GF + E +++L++D KV + +G N+ Sbjct: 136 FRLNEDKAIVNRYGFNSEGH------EVVFERIKKLRQDGDLKVTLGINLGRNKKSEDNI 189 Query: 117 EELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA---VKRGSTLPM 171 E+ + +++ AD + N S P + L+ + +A + P+ Sbjct: 190 EDYVQGIRKFSVLADYLVVNISSPNTPGLRTMQNKSTLQSLLTEIVKARNALPPNEQRPI 249 Query: 172 LAKMTPNIGD--MCEVALAA--KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 L K+ P++ D + E+ K DG+ NT + + G + Sbjct: 250 LVKIAPDLSDGCVQEIIAVIQKKECAIDGLIVSNTTIDRPSELKSINAGQ--------LG 301 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG + + + + ++ PI G+GGI + DA E +L GA+ +Q+ T ++ Sbjct: 302 GLSGAPLSSKSTQLVAKVYKWTG-GRVPIIGVGGIFSGRDAYEKILAGASAVQLYTALIY 360 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQE 314 +G IV + L L + G++++Q+ Sbjct: 361 HGPPIVARVKEELGQLLKENGYENVQQ 387 >UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobacteria RepID=Q1GGD3_SILST Length = 352 Score = 233 bits (593), Expect = 1e-59, Method: Composition-based stats. Identities = 72/334 (21%), Positives = 123/334 (36%), Gaps = 32/334 (9%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 + + L G+ PNP L++ N E A + G+G + P Sbjct: 39 VTSPRLRTDVAGLSLPNPVGLAAGFDKN-AEALAPLSEAGFGFIEVGAATPRPQPGNPKP 97 Query: 60 RFDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ-- 115 R L ++ GF N + + P +I +G N+ Sbjct: 98 RLFRLSEDRAAINRFGFNNEGM----------DTIGKRLAQRPKSGVIGLNLGANKDSED 147 Query: 116 -WEELARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPM 171 ++ AR++ GA D N S P L+ A + +P+ Sbjct: 148 RAQDFARVLSHCGAHLDFATVNVSSPNTEKLRDLQGKDALASLLAGVIDAREALQRPIPV 207 Query: 172 LAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ + ++A A+ G D + A NT S + + + G Sbjct: 208 FLKIAPDLDISGLDDIAEVARDSGIDAVIATNTTLSRDGLKST---------HRDEMGGL 258 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG + + R + Q+ PI G+GGI T E A + GA+ +Q+ T ++ G Sbjct: 259 SGAPLFERSTRVLAQLSQRL-DGAVPIIGVGGISTAEGAYAKIRAGASAVQLYTALVYGG 317 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 + ++ASGL LA GF ++ E VG + Sbjct: 318 LSLASEVASGLDALLARDGFSNVAEAVGTGRADW 351 >UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEG1_METST Length = 306 Score = 233 bits (593), Expect = 1e-59, Method: Composition-based stats. Identities = 96/318 (30%), Positives = 162/318 (50%), Gaps = 17/318 (5%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G+K NP L++ +G G GG+V K+ +P + Sbjct: 2 LEQEILGMKLSNPLFLAAGILGTTASSMKMVARAGAGGIVTKSFSIEANDGYDNPTIVKI 61 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 +G + +E L+ L E +IASI G++E+ + ++A + Sbjct: 62 EGGVINSVGLASP------GVEAKKEELKDLNEIRDKTPVIASIYGDSEEVFSDVANQTK 115 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLAKMTPNIGDMC 183 + D E N SCP GS++G++PEL +VK +P++ K+TPN+ D+ Sbjct: 116 DY-VDAFELNVSCPH-AKCGFGSNIGENPELTHDIVSSVKDNIKDVPIIVKLTPNVTDIT 173 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 E+A AA+ GAD + IN+V + ++ K PI+N + G +G +KPIAL+ + Sbjct: 174 EIAKAAEDAGADALTLINSVG--PGLRIDYKTARPILN--NVFGGIAGPMIKPIALKCVY 229 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + E D P+ G+GGI T++DA EFL GA+ LQ+ T IM G I +++ LS++ Sbjct: 230 KTY---ETVDIPLFGVGGIRTYKDALEFLYAGASLLQIGTSIMYEGPEIFKNITHDLSNF 286 Query: 304 LADQGFDSLQEMVGLANN 321 L + G+ +++E++GL++N Sbjct: 287 LEENGYKNVEEIIGLSHN 304 >UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YYV3_METPS Length = 315 Score = 232 bits (592), Expect = 2e-59, Method: Composition-based stats. Identities = 93/309 (30%), Positives = 146/309 (47%), Gaps = 22/309 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 T L++ G+ NP L++ +G + G G VV K+IG +P Sbjct: 9 TMKLTVEAGGLTLTNPTILAAGILGTTGASLKRVASMGAGAVVTKSIGAEPKYGHPNPSM 68 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L +G N +E L L K+ +IASI G E ++ E+A+ Sbjct: 69 IRLECGYINAMGLPNP------SYKEFLPELETAKDS--GVPVIASIFGATEAEFIEVAK 120 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + GA E N SCP + M VG P LV+ AVK P+ K+TPN+ D Sbjct: 121 GL--PGASAYELNVSCPHARGYGM--QVGTDPALVKAIAHAVKGTVNAPVWVKLTPNVTD 176 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + + AA+ GGAD + AINT+K+ I ++ G PI+ + G SG A+KP+A+R Sbjct: 177 ITSIGRAAQEGGADAVVAINTLKA---IAIDIDSGYPILG--NIQGGLSGPAIKPVAVRC 231 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + + + D P+ G GG+ +W DA EF++ GAA +++ + + + ++ GLS Sbjct: 232 VYDLYSAL---DIPVIGAGGVSSWADAVEFIMAGAAAVEIGSA-VYDDIGVFAAVSMGLS 287 Query: 302 HYLADQGFD 310 YL + Sbjct: 288 DYLDRKNMT 296 >UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria RepID=PYRD_THEFY Length = 377 Score = 232 bits (591), Expect = 2e-59, Method: Composition-based stats. Identities = 75/326 (23%), Positives = 120/326 (36%), Gaps = 29/326 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 +L + G +FP P L++ N A G+ V T+ PR Sbjct: 49 PELRVRVFGREFPGPLGLAAGFDKN-ARGVAALTALGFSHVEIGTVTGQPQPGNPRPRLF 107 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 LV + +GF N A LR + +++ +G+ + Sbjct: 108 RLVADRAIVNRMGFNNEGSQAVS------ERLRAHRARRARDLIVGVNIGKTKVVPDSDA 161 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS--TLP 170 + AR + AD + N S P + L+ R + LP Sbjct: 162 VADYVTSARRFADL-ADYLVVNVSSPNTPGLRDLQATERLRPLLSAVRRTLDEAGRPDLP 220 Query: 171 MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ D+ VA A G DGI A NT S + + P G Sbjct: 221 LLVKIAPDLADEDIDAVADLAVELGLDGIIATNTTVSRDGLATD-----PEEVAALGAGG 275 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG +K AL+ ++++R + +GGIET EDA + GA +Q TG++ Sbjct: 276 LSGAPLKERALQVLRRLRARVGD-RLVLIAVGGIETPEDAWARIRAGATLVQGYTGLIYG 334 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQE 314 G + G++ GF S+ E Sbjct: 335 GPLWPRRIHRGVAALARRDGFASIAE 360 >UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Schizosaccharomyces RepID=PYRD_SCHPO Length = 443 Score = 232 bits (591), Expect = 2e-59, Method: Composition-based stats. Identities = 66/346 (19%), Positives = 121/346 (34%), Gaps = 47/346 (13%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L++ G KF NP L++ + + + G+ + ++ PR+ Sbjct: 103 PSLAVEVWGKKFCNPIGLAAGFDK-QADAISGLLNFGFSYLEIGSVTPKPQPGNPKPRYF 161 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENL-AALRRLKEDYPDKVL----------------- 104 L K D I I + + +R+ ++L Sbjct: 162 RL-KPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPAVLG 220 Query: 105 ----------IASIMGENEQ--QWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVG 150 + +G+N+ + E+ V+ G AD++ N S P Sbjct: 221 VPRSLIPNKFLGINLGKNKNGNEIEDYVEGVRTFGNFADILVINVSSPNTPGLRNLQKKS 280 Query: 151 QSPELVEKYCRAVKRGS--TLPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSI 206 L+ + + P+L K+ P++ ++ ++A K+ DG+ NT Sbjct: 281 ALSTLLTAVVSERNKLNSPHPPVLVKIAPDLNEEELTDIADVLKKCKIDGVIVGNTTVQR 340 Query: 207 TNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWE 266 + G SG +KPIAL ++ +R H D PI G GGI + + Sbjct: 341 PKTLKSTSHVE-------ETGGLSGPPLKPIALNTLRTLRKHL-SSDIPIIGCGGISSGK 392 Query: 267 DAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSL 312 DA E+ GA +QV T + G I + + L + + + Sbjct: 393 DAIEYARAGATMVQVYTALGYDGPVIAHKIKQEILAELKGKRWVDI 438 >UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago maydis RepID=Q0GF37_USTMA Length = 677 Score = 231 bits (589), Expect = 4e-59, Method: Composition-based stats. Identities = 69/363 (19%), Positives = 123/363 (33%), Gaps = 74/363 (20%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G K NP L++ E D G+G + ++ PR+ L Sbjct: 140 LETELFGRKLSNPIGLAAGFDK-QAEAIDGLLDLGFGFIEIGSVTPEPQPGNPQPRYFRL 198 Query: 65 VKEDT--GFIGFKNMEQIAE-----HPLEENL---AALRRLKEDYPDKVLIASIMG---- 110 ++++ GF + + L +++ L++ AS+ Sbjct: 199 IEDNACINRFGFNSEGHNVILSRLRDRIRRWLLHSSSVANLQDALLASPDSASVNARQLI 258 Query: 111 -----------------------------------ENEQQWEELARLVQEAG--ADMIEC 133 NE+ ++ + V+ G ADMI Sbjct: 259 ATHPKSTSAFVDATDLPRSLRPAKMLGINLGKNKTSNEESVDDYVKGVERLGPYADMIIV 318 Query: 134 NFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-----------RGSTLPMLAKMTPNIGD- 181 N S P G +L+ + RA + +P+L K+ P++ + Sbjct: 319 NVSSPNTPGLRRLQRRGVLEDLLTQVVRARDGMVESHLRFSDKKVAVPLLVKIAPDLSEE 378 Query: 182 -MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + +VA AA + G DG+ NT S + + G SG VKP+AL+ Sbjct: 379 ELHDVADAALKSGIDGLVISNTTISRPASLRSSEHVR-------ETGGLSGAPVKPLALK 431 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + + PI G GGI +DA ++ GA+ +++ T G + + L Sbjct: 432 ALTTVHKRLQ-GKLPIIGCGGISNGQDALDYAKAGASAIELYTSFGYQGVGLPRRLKDEL 490 Query: 301 SHY 303 Sbjct: 491 VEL 493 >UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchaeota RepID=PYRD_UNCMA Length = 301 Score = 231 bits (589), Expect = 4e-59, Method: Composition-based stats. Identities = 88/308 (28%), Positives = 143/308 (46%), Gaps = 22/308 (7%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 ++ G+ NP L++ +G + G G VV K+IG +P Sbjct: 1 MKITCNAGGLTLKNPTILAAGVLGTTGASLKRIASMGAGAVVTKSIGTEPKPGHHNPSMI 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L + +G N E L +E +IASI G +++ +A Sbjct: 61 RLEEGYINAMGLPNP------SFGEFRQELEIARES--GVPVIASIFGATPEEFTAVANG 112 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + GAD E N SCP + M G PELV +AVK +P+ K+TPN+ D+ Sbjct: 113 L--PGADAYELNVSCPHAKGYGM--QCGTDPELVRSITKAVKAAVKVPVWVKLTPNVTDI 168 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + LAA+ GGAD + AINT+K++ ++ G PI+ +S G SG AVKP+A++ + Sbjct: 169 RPIGLAAQEGGADAVVAINTLKAMA---IDINTGWPILGNRS--GGLSGPAVKPVAIKCV 223 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + D P+ G+GG+ W DA EF++ GA +++ + + ++ G+S+ Sbjct: 224 YDLYEVL---DIPVIGVGGVSNWADAIEFMMAGACAVEIGSA-VYEDIGTFASVSMGISN 279 Query: 303 YLADQGFD 310 YL + Sbjct: 280 YLDRKNMK 287 >UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=PYRD_CARHZ Length = 307 Score = 231 bits (588), Expect = 5e-59, Method: Composition-based stats. Identities = 83/320 (25%), Positives = 143/320 (44%), Gaps = 20/320 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 +L + + NP +S G E G +V KTI PR Sbjct: 1 MNLKVKIGELTLKNPVMPASGTFGFGLEFKDIFDLKNLGALVVKTITKNPRLGNRPPRVY 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + IG N ++ E+ L ++ L + +LI +I GE+ ++++ LAR Sbjct: 61 EVSCGMINSIGLANPG--WDYFCEKILPQIKDLND-----ILILNIAGESVEEFQYLARE 113 Query: 123 VQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 Q +E N SCP ++ G G E +++ +V++ + ++ K+TPN+ D Sbjct: 114 AQRFDEIKALELNVSCPNVSKG--GIAFGTDLEALKQIVSSVRKIYSKTLIVKLTPNVTD 171 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + A AA+ GAD + INT + ++ K PI+ K G SG A++P+A++ Sbjct: 172 ITVYAKAAENAGADALTLINTFTGMV---IDVKSKKPILGNKH--GGVSGPAIRPMAVKM 226 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + PI G+GGI++ E A EF L GA +QV + + + L Sbjct: 227 VYDCFKAV---SIPIIGVGGIDSKEAALEFFLAGATAIQVGSQNFVE-PGFMPRLIRELG 282 Query: 302 HYLADQGFDSLQEMVGLANN 321 YL ++ +S+ ++ GLA+ Sbjct: 283 EYLQEENIESIAKLTGLAHR 302 >UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q682_MALGO Length = 665 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 75/356 (21%), Positives = 119/356 (33%), Gaps = 70/356 (19%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G NP L++ E +D G+G V +I +PR L Sbjct: 115 LRTELFGKTLTNPIGLAAGFDKQG-EAIDGLFDLGFGLVEIGSITPEPQPGNPTPRMFRL 173 Query: 65 VKEDT--GFIGFKNMEQIAEHP-----LEENLAALRRLKEDY------------------ 99 + +GF + A L + + + E Sbjct: 174 PLDAAVINRMGFNSEGHEAVRERLHARLHKWVQRVLSAGEGLVSSVGAPAPEPTALAEAQ 233 Query: 100 --PDKVLI--------------------ASIMGENE----QQWEELARLVQEAGA--DMI 131 + +I + +G+N+ + + VQ GA DM+ Sbjct: 234 VFANYPVINTSLLDDAHVPRSLKQDRLLSINLGKNKSSREDSVVDYVKGVQALGAYADML 293 Query: 132 ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-----LPMLAKMTPNIGD--MCE 184 N S P ++ A + LP++ K+ P++ D + + Sbjct: 294 VINVSSPNTPGLRRLQRRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELED 353 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 VA AA+ DGI NT S L+ + G SG VKP+AL +Q Sbjct: 354 VADAARASKIDGIIVSNTTVSRPAGLLSTQHVH-------EAGGLSGPPVKPLALHALQV 406 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + E P+ G GGI T EDA EF GA+ +Q+ T + G + + L Sbjct: 407 IYKRSE-GKIPLIGCGGIMTAEDALEFARAGASAVQLYTALAYRGPGLPRRIKDDL 461 >UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular organisms RepID=PYRD_BRASB Length = 364 Score = 230 bits (586), Expect = 9e-59, Method: Composition-based stats. Identities = 72/326 (22%), Positives = 129/326 (39%), Gaps = 32/326 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L++ G+ FPNP +++ N E+ G+G V ++ PR Sbjct: 42 AKLAVRAFGLNFPNPVGMAAGFDKN-AEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLF 100 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ---WE 117 L +++ +GF N + LRRL ++ +G N+ Sbjct: 101 RLERDEAVVNRMGFNN---------DGAEIVLRRLAGRANQGGIVGVNVGANKDSADRVA 151 Query: 118 ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA----VKRGSTLPM 171 + RL++ A N S P Q EL+ K A ++ P+ Sbjct: 152 DYVRLIETFAPVASYFTVNISSPNTPGLRNLQQAAQLNELLSKVLEARDRVRRKAGDTPV 211 Query: 172 LAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 L K+ P++ ++ +V A+ G DG+ NT + N Q G Sbjct: 212 LLKIAPDLSLAELDDVVHVARSRGVDGMIVSNTTLARPNSLREQLRAK-------EQGGL 264 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG+ + ++ R + + E FP+ G+GGI++ A + GA+ +Q+ + ++ G Sbjct: 265 SGRPLFRLSTRMVAETFVRVE-GAFPLIGVGGIDSGGAALTKIRAGASLIQLYSSLVYKG 323 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEM 315 +VE + + L+ L G DSL E+ Sbjct: 324 LGLVESIKADLTSTLLRTGRDSLSEI 349 >UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=PYRD_SOLUE Length = 304 Score = 229 bits (584), Expect = 1e-58, Method: Composition-based stats. Identities = 89/316 (28%), Positives = 140/316 (44%), Gaps = 22/316 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 +T L+ T CG+ NP +S E GG V K + PR Sbjct: 1 MTPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHP-LEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + + G I ++ I + E L AL L+ + A++ G + + E+ Sbjct: 61 VF---ESEAGMINSVGLQNIGVRAFVAEKLPALAGLRTA-----VFANVFGYCTEDYVEV 112 Query: 120 ARLVQE-AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R++ + AG E N SCP G P L+ + A KR +T P++ K++PN Sbjct: 113 VRVLNDHAGLAGYELNVSCPNTAHG--GIYFSNDPVLLAEVVTAAKRVATRPLIVKLSPN 170 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + + +A A+ GAD ++ +NTV S + ++ + P + G SG A+KPIA Sbjct: 171 VSAIEPLARVAEESGADALSLVNTVIS---LAIDARTRRPRIGA--GFGGLSGPAIKPIA 225 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LRF+ Q P+ G+GGI T EDAAEFL+ GA+ ++V T R +A Sbjct: 226 LRFVYQAARAVR---IPVIGLGGIATGEDAAEFLIAGASAVEVGTATFW-DPRAPLRIAE 281 Query: 299 GLSHYLADQGFDSLQE 314 L +L +G + Sbjct: 282 ELGKFLEREGIRKATD 297 >UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria RepID=PYRD_CHLAA Length = 363 Score = 229 bits (584), Expect = 2e-58, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 108/313 (34%), Gaps = 33/313 (10%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L T CG+ FPNP L++ + G+G V T+ PR Sbjct: 59 RLQRTVCGIPFPNPVGLAAGMDKDGV-AIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFR 117 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQ 115 L +++ I L LA L+ + SI G+++ Sbjct: 118 LPEQEA-LINRMGFNNQGAASLARRLARLQPAP-----IPVGVSI-GKSKITPLEQAIDD 170 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKY------CRAVKRGSTL 169 + R + A I N S P D Q L+ + Sbjct: 171 YRASFRQLFPY-AAYIAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPR 229 Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+L K+ P++ D + EV G GI A NT S + + Sbjct: 230 PLLVKIAPDLSDTAIEEVLTVCADHGVAGIIATNTTISREGL------TGVDPRLAAEAG 283 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ + AL ++ + PI G+GGI T +D L GA+ +Q+ TG++ Sbjct: 284 GLSGRPLIARALHVVRLIARLTGN-RLPIIGVGGIHTPDDGLRMLEAGASLIQIYTGLVY 342 Query: 288 YGYRIVEDMASGL 300 YG + + + Sbjct: 343 YGPLLPRRINRAI 355 >UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotate dehydrogenase B) catalytic subunit n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q4L5_9BACT Length = 306 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 82/321 (25%), Positives = 154/321 (47%), Gaps = 15/321 (4%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 M LSI C ++ NP L+S +G + + ++G G V K++ Sbjct: 1 MTEVTLSINLCSMRLSNPTVLASGILGTTKTLLKRVAESGAGAVTIKSVSKDSREG---- 56 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 H T G N + +E L E +IASI+G + E+A Sbjct: 57 -HHNPTVITYEAGMLNAVGYSNPGVEAARIEYSNLNEI--GVPVIASIIGTCTDDFIEVA 113 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 + +G IE SCP + S G +P+ + AV+R + +P+ K++PN+ Sbjct: 114 EGLSASGFSAIEIPLSCPHTPGFGLLSGQG-TPKATYEITYAVRRKTNVPIFVKISPNVP 172 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++ +A AA+ GA+GI A+N++ + +N + P++ K + G +G A++PIA+R Sbjct: 173 EITSIAKAAEDAGANGITAVNSMG--PGMVINIESKKPVLGFK--VGGVTGDALRPIAVR 228 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + + PI G+GGI T A E ++ GA+ + + TG+ G + + + + Sbjct: 229 CVYDVYQAVK---IPIIGVGGISTGRHAIEMMMAGASAVGIGTGVYTRGINVFSKVCAEM 285 Query: 301 SHYLADQGFDSLQEMVGLANN 321 ++ + G++++ E+VG+A++ Sbjct: 286 KQWMIENGYNTINELVGVAHD 306 >UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NV76_9GAMM Length = 367 Score = 228 bits (581), Expect = 3e-58, Method: Composition-based stats. Identities = 69/333 (20%), Positives = 119/333 (35%), Gaps = 32/333 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L+ G+ F +P L++ + + G+ + T+ PR Sbjct: 49 PRLAQELWGLHFAHPVGLAAGFDKDG-QALKSLASVGFAFLELGTVTPRPQPGNPGPRIF 107 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA-- 120 ++ I + + RL P V + +G+N + A Sbjct: 108 RYPQQRA-VINRLGFPSQGGSAVAD------RLAATLPLTVPLGINIGKNRETPLTAAVG 160 Query: 121 ---RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-KRGSTLPMLAK 174 L+Q+ G AD I N S P D L+++ A K P+L K Sbjct: 161 DYRALIQQLGPFADYISINVSSPNTPELRRLQDPQSLRPLLQELREARQKLQRQPPLLLK 220 Query: 175 MTPNI--GDMCEVALAAKRGG--ADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 + P++ ++ +A A+ DG A NT + G S Sbjct: 221 IAPDLAPDEVTALAALAQEPQPLLDGFIATNTTLGRP----------SDWPHPAEAGGLS 270 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G +K A I Q+ PI G+GG+ T +D + + GA+ +Q+ T ++ G Sbjct: 271 GAPLKRRANGIIAQLYRAS-SGRLPIIGVGGVATAQDVLDKIEAGASLVQLYTALIYEGP 329 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 +V+ + L L D+G D L +VG + Sbjct: 330 DLVQQITDALPELLTDRGVDHLGALVGRRAEHW 362 >UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus delbrueckii RepID=Q1G992_LACDA Length = 309 Score = 228 bits (580), Expect = 4e-58, Method: Composition-based stats. Identities = 87/286 (30%), Positives = 140/286 (48%), Gaps = 17/286 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 +L++ G+K NP +S ++ G +V KT P+ D Sbjct: 5 VNLAVELPGLKLKNPVMPASGTFAFG-DLPENFNWDEMGAIVLKTATRHARTGNPQPQID 63 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L +G N + L+E +PD ++AS+ GE+ + + E+A + Sbjct: 64 LLADGVMNAVGLTNPGAEVVAS-----EKIPALREKHPDLPILASVGGESVEDYVEVAEI 118 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 + A D +E N SCP ++ M G PE++EK R VK LP+ K+TPN+ + Sbjct: 119 LAAAKPDALELNLSCPNVSEGGMT--FGIVPEMLEKITRLVKEKVDLPVYVKLTPNVTSI 176 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E+A AA+ GGADG+ INT+ + L+ K P++ + G G+AVKP+A+R + Sbjct: 177 VEIAQAAEGGGADGLTLINTLL---VLHLDLKTRRPVLG--NDFGGLYGQAVKPVAVRMV 231 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 Q++ PI G+GGI + EDAAEF+L GA+ +Q+ + Sbjct: 232 AQVKQAT---SLPIIGVGGINSPEDAAEFILAGASAVQIGSMSFYD 274 >UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidales RepID=PYRD_BACV8 Length = 303 Score = 226 bits (577), Expect = 9e-58, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 139/315 (44%), Gaps = 20/315 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 DLS+ +K NP +S G E GG++ K PR Sbjct: 1 MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRM 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 +G +N ++ +E +R + + +I ++ G + + + A Sbjct: 61 AETPMGMLNAVGLQNKGV--DYFVEHIYPQIRDIHTN-----MIVNVSGSAVEDYVKTAE 113 Query: 122 LVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++ + IE N SCP + M G S + +AV+ ++ K++PN+ Sbjct: 114 IINDLDHIPAIELNISCPNVKQGGM--AFGVSACGCSEVVKAVRNVYKKTLIVKLSPNVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ E+A AA+ GAD ++ INT+ + ++ + + G SG AVKPIALR Sbjct: 172 DITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTI-----TGGMSGAAVKPIALR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q+ + P+ G+GGI W+DA EF+L GA +Q+ T I ++ G+ Sbjct: 227 MVWQVAKAV---NIPVIGLGGIMGWKDAVEFMLAGATAIQIGTANFI-DPAITVKVSEGI 282 Query: 301 SHYLADQGFDSLQEM 315 + YL G+ S++++ Sbjct: 283 NDYLERHGYTSVKDI 297 >UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae RepID=Q2S001_SALRD Length = 366 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 118/330 (35%), Gaps = 33/330 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 + L G FPNP L++ N G+G V ++ +PR Sbjct: 45 ERLKQRLWGDTFPNPVGLAAGADKN-ARAVPFWEAVGFGFVEVGSVSAQPAPGNPTPRAF 103 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM-GENEQQWEELAR 121 L K D I + + + L R + L ++ + E A Sbjct: 104 RLPK-DQALINRLGLNNDGAEAVADRLEHSR----SDRARPLGINLAKTHDPDIMGEAA- 157 Query: 122 LVQEAG---------ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPM 171 +++ AD + N SCP D L+ K G +P+ Sbjct: 158 -LEDFRTSFRQLVGQADYVTLNVSCPNTPDGGTFEDPAALDALLGAITAEQKAPGLAVPV 216 Query: 172 LAKMTPNIGD-------MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 L K++P + D + E+ A DG A NT ++ + + Sbjct: 217 LVKLSPPLSDRVLFDTRLEEILAVAADHDIDGFIATNTASDRKGVETSADRLD-----EI 271 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG ++ A R +Q + + PI G+GG+ E A + GA+ +Q+ T Sbjct: 272 GAGGLSGPPLEARATRLVQYLYRAT-DGEIPIIGVGGVHDAESAYTKIRAGASLVQLYTA 330 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSLQE 314 ++ G +V + GL L+D G+ SL+ Sbjct: 331 LVYEGPGLVRRIKEGLVARLSDDGYASLEN 360 >UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae RepID=A9HBE5_GLUDA Length = 357 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 118/328 (35%), Gaps = 26/328 (7%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L++ G++FPNP +++ N + G+G V T+ PR Sbjct: 44 PALAVRALGLRFPNPIGIAAGFDKNAL-VVRPLARIGFGFVEAGTVTPRPQPGNPRPRLF 102 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRL----KEDYPDKVLIASI----MGENEQ 114 L ++ I LA L R+ + + A++ G + + Sbjct: 103 RLDEDRA-IINRMGFNNQGIDRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGADPE 161 Query: 115 -QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 + L V+ AD + N S P + + L++ A P+L Sbjct: 162 RDYPRLVGRVKHY-ADYVVLNLSSPNTPGLRDLQEASRLGALLQAIGEA--HPDRPPLLV 218 Query: 174 KMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K++P++ D+ + AA GGA G+ NT S G SG Sbjct: 219 KLSPDLARDDIGPIVEAAIAGGAQGLIVTNTTISRP--------AGLRSPHAGEAGGLSG 270 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + ++P+A + + + GGIET D + + GA +Q+ + G Sbjct: 271 RPLRPLAADIFRAVAQ-VAAGRLALVACGGIETGADIVDRVRAGADLVQLYSAFAYEGPG 329 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLA 319 IV + L +GF++L + G A Sbjct: 330 IVRRLKRETVRVLNAEGFETLADAKGTA 357 >UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UZD6_NAEGR Length = 369 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 117/327 (35%), Gaps = 24/327 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L G F NP L++ E G+G + +I PR Sbjct: 37 SLHTNCLGYHFENPIGLAAGFDK-DAECMKGIEKLGFGFMEVGSICPQPQPGNPKPRIFR 95 Query: 64 L---VKEDTGFI-----GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--- 112 L V + G I +ENL R + I +G+N Sbjct: 96 LNSKVSDPDGTIFDTILNRCGFNSKGMEVSDENLTTYRNSYQSLNTFP-IGVNLGKNKTS 154 Query: 113 -EQQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL 169 + E+ V++ AD + N S P + L+E+ +K+ + Sbjct: 155 APESIEDYLIGVRKLAKHADFLVINVSSPNTQHLRSLQEKSSLDTLIEEVSTELKKHKNI 214 Query: 170 PMLAKMTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+L K+ P+ + ++A A + GI NT + Q +P S Sbjct: 215 PLLIKIAPDLTLDQQRDIASLALKHSIGGIIVSNTTIERPFVSSEQINAIP----NGSAG 270 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ + + + ++ M E + G+GG+ DA + + GA+ +QV T Sbjct: 271 GMSGRPLFNQSTKVLKNMYKLTE-GKVTLIGVGGVWDGYDALQKIQAGASLVQVYTAFTA 329 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQE 314 G +V + L+ LA+ G+ + + Sbjct: 330 QGPAVVGKIKRELAQLLAEGGYARVSD 356 >UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=C8WHP0_EGGLE Length = 356 Score = 226 bits (575), Expect = 1e-57, Method: Composition-based stats. Identities = 78/314 (24%), Positives = 134/314 (42%), Gaps = 19/314 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPR 60 + D+ + G++ NP ++S E G G V K + A SPR Sbjct: 54 TSVDMRVNLGGLEMKNPVTVASGTFAAGREYGDFVDVAGLGAVTTKGVSLNGWAGNASPR 113 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 IG +N H E +L L +I ++ G + ++ ++ Sbjct: 114 IAETPSGMLNSIGLQNPGV--AHLKECDLPWLAE-----RGATVIVNVSGHSFDEYVQVI 166 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 +++ D E N SCP + + M +G + VE + + P++ K+TPN+ Sbjct: 167 EALEDVPVDAYEVNISCPNVDAGGMT--IGTCTDSVEAVVSRCRAATKRPLIVKLTPNVT 224 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ E+A AA GAD ++ INT+ + ++ + + G SG AVKP+ALR Sbjct: 225 DVTEIARAAVSAGADALSLINTLLGMAIDAERRRPQL-----ARGVGGLSGPAVKPVALR 279 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ D P+ G+GGI DA EF+L GA + V T ++ G+ Sbjct: 280 MVWEVHQAV---DVPLLGMGGISCATDAVEFMLAGATAVAVGTANFVN-PHATVEIIDGM 335 Query: 301 SHYLADQGFDSLQE 314 + Y G + +Q+ Sbjct: 336 AQYCERHGIEDVQQ 349 >UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma RepID=C4QIG2_SCHMA Length = 379 Score = 226 bits (575), Expect = 2e-57, Method: Composition-based stats. Identities = 55/316 (17%), Positives = 111/316 (35%), Gaps = 21/316 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L G++F +P L++ + + G+ + T+ PR Sbjct: 71 PQLKCKVFGLEFDHPIGLAAGFDKDGKAFM-GLLNAGFSHIEVGTVTPNPQLGNARPRIF 129 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW---EEL 119 +++ + + E L + + +I +G N+ + Sbjct: 130 RWTEKEA-VVNRCGFNSDGHDAVYERLKD-----RPWEGRGVIGVNLGCNKTSADPTADY 183 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL-PMLAKMT 176 V++ G AD + N S P + +L+ K A + S P+L K++ Sbjct: 184 VAGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLRDLLSKVLAARNQLSKKTPILLKIS 243 Query: 177 PNIGD--MCEVALAAKRGG--ADGIAAINTVKSITNIDLNQKIGMPIVNGK--SSISGYS 230 P+ D + ++ A DG+ NT + + N K G S Sbjct: 244 PDENDQNLKDIVEVALDSKTRIDGMIISNTTLTTYEEAVACGAAPIPGNNKQNVVYGGLS 303 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G+ + + ++++ + P+ G+GGI EDA L GA+ +Q+ T + G Sbjct: 304 GRPLFEKSTDCLRKVSALTK-GAIPLIGVGGISCGEDALSKLNAGASLVQLYTSFVYQGP 362 Query: 291 RIVEDMASGLSHYLAD 306 + +A ++ Sbjct: 363 PVAHKVAREINKLKMT 378 >UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteriaceae RepID=D2S350_9EURY Length = 356 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 69/323 (21%), Positives = 122/323 (37%), Gaps = 32/323 (9%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L + FPNP +++ N E+ G+G V T+ + PR Sbjct: 48 HPALEVDLFDSTFPNPVGIAAGFDKN-AEVTHALEALGFGFVEIGTVTPYPQEGNDRPRL 106 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN----EQQWE 117 L +++ G I ++E L + P L +I N + E Sbjct: 107 FRLREDE-GMINRMGFNGQGMETVKERLEE-----DGTPGFPLGVNIGKMNSSTEREAIE 160 Query: 118 ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG--STLPMLA 173 + R+ AD + N SCP SPE + ++ +PML Sbjct: 161 DYRRVFDRVSPFADYVVVNVSCPNTPDEFN----EASPEHLRAIFETLEAENDGNVPMLV 216 Query: 174 KMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P+ + + ++ + G DGI A NT + ++ + G SG Sbjct: 217 KIGPDEPEDAILDLVDIVQEFGLDGIVATNTSTAREGLES---------PAREEWGGLSG 267 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 ++ + I+ + H + PI G+GG+++ A E + GA+ +Q+ TG + G Sbjct: 268 APIEDRSTDVIRTIAGHT-DGELPIVGVGGVDSAASAYEKIRAGASLVQLYTGFVYRGPS 326 Query: 292 IVEDMASGLSHYLADQGFDSLQE 314 + GL L GF S+++ Sbjct: 327 TAGRINQGLVDLLERDGFSSVED 349 >UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria RepID=PYRD_ROSCS Length = 367 Score = 224 bits (572), Expect = 3e-57, Method: Composition-based stats. Identities = 65/334 (19%), Positives = 124/334 (37%), Gaps = 37/334 (11%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L + + G++F +P +++ ++ G+ V T+ PR Sbjct: 48 PALMVEWAGLRFASPLGVAAGFDKR-ADLVDALALLGFSHVEVGTVTPRPQPGNPGPRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 L ++ +GF + +A + L+ +V++ +G+N E Sbjct: 107 RLPEDMALINRLGFNSHGMVAVA---------KALRARRSRRVIVGVNIGKNRDTPLE-- 155 Query: 121 RLVQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLP 170 R V++ A D + N S P + EL+ + R P Sbjct: 156 RAVEDYAATFVALAPLADYVAVNISSPNTPGLRRLHERAALEELLRELMRLNHGLLYPRP 215 Query: 171 MLAKMTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 + K++P+ + + EV A G A NT + + + G Sbjct: 216 IALKISPDETLDQIEEVVRAGCEAGVAAFIATNTTLAREGL---------RSRLANETGG 266 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG+ + P A + I+ + P+ G+GG+ T +DA + GA +Q+ TG++ Sbjct: 267 LSGRPLAPRARQVIRAIYRLTRGTP-PVIGVGGVLTADDAYAHIRAGARLVQLYTGMVYA 325 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 G I ++ GL+ L GF S+ + G+ Sbjct: 326 GPAIAREIKRGLAQLLRRDGFVSVTQATGVDAEW 359 >UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacteria RepID=PYRD_CYAP8 Length = 377 Score = 224 bits (571), Expect = 5e-57, Method: Composition-based stats. Identities = 64/330 (19%), Positives = 115/330 (34%), Gaps = 23/330 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L T G+ F NP L++ G+G + PR Sbjct: 59 SRLKQTLWGLTFNNPVGLAAGCDKEGI-AAGIWSHLGFGFAELGAVTLHPQPGNPRPRLF 117 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 L + +G N E L + + P + I + +++ + Sbjct: 118 RLPHDKAVLNRLGANN------QGAEIMAQTLAEIWQRSPRNIPIGINLCKSKITPLDEA 171 Query: 116 WEELARLVQ--EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 ++ E AD N S P + Q +++ A P+ Sbjct: 172 AQDYVGSFSYLENQADYFVVNVSSPNTPGLRSLQEGEQLNSILQALQAA--NQHQKPLFV 229 Query: 174 KMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K++P++ + + + A+ GI A NT + Q + + G SG Sbjct: 230 KISPDLEEEAILTIIELAQTHCLAGIIATNTTIKRDRL-TTQILPETGNKIQEEAGGISG 288 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 ++ + I + + PI G+GGI T +DA ++ GA+ LQ+ TG + G Sbjct: 289 LPIRDRSTEIIGFIYQKTQ-GKLPIIGVGGIFTPDDAWNKIIAGASLLQLYTGWIYQGPW 347 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANN 321 I+ D+ GL L G + + VG+ + Sbjct: 348 IIPDIVRGLGDKLKQLGLSHISQAVGINHK 377 >UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, putative n=3 Tax=Agaricomycotina RepID=Q5KK62_CRYNE Length = 591 Score = 223 bits (569), Expect = 7e-57, Method: Composition-based stats. Identities = 71/373 (19%), Positives = 132/373 (35%), Gaps = 44/373 (11%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 +L G+ NP +++ E +D G+G V ++ PRF Sbjct: 102 AELQAELFGMHLKNPVGIAAGFDK-DAEAIDGLFDLGFGYVEVGSVTPEPQPGNPKPRFF 160 Query: 63 HLVKEDT--GFIGFKNME--------------------QIAEHPLEENLAALRRLKEDYP 100 L ++D GF ++ + PL NL L Sbjct: 161 RLEEDDACINRYGFNSLGHGHALARLRLRLAKFAQDHPSLFPSPLPANLVPPAGLPRSLR 220 Query: 101 DKVLIASIMGEN----EQQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPE 154 L+A +G+N ++ R V+ G AD++ N S P Q Sbjct: 221 AGQLLAVNLGKNKASDPDSNDDYVRGVRTLGPFADVVVINVSSPNTPGLRALQGKQQLER 280 Query: 155 LVEKYCRA---VKRGSTLP-MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITN 208 L+ + +G+ LP + K+ ++ ++ +VA A + G +G+ NT Sbjct: 281 LLNDVVEERNKIAQGTGLPKIAVKVASDLSEDELADVASAVRSSGVEGVIVSNTTIRRKE 340 Query: 209 IDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDA 268 ++L + + I G SGK + P AL ++ +R PI G GGI + DA Sbjct: 341 LNL-------VSGNQDQIGGLSGKPLFPYALNALKTLRPLLP-PSIPIIGCGGISSGSDA 392 Query: 269 AEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAED 328 GA+ +QV T G + ++ +L + + + ++ + ++ Sbjct: 393 LTMANAGASIVQVYTSFGFRGVGTPRLIKDEITEHLKGESWKTHVGRDWASSGQPMGWDE 452 Query: 329 LDRSYIVYPRINL 341 ++ Sbjct: 453 NRLKQESQALVDE 465 >UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria RepID=PYRD_DESAP Length = 307 Score = 223 bits (567), Expect = 1e-56, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 147/322 (45%), Gaps = 20/322 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + ++ G+ NP +S VG E G G +V KT+ PR Sbjct: 1 MKVKTAVAIAGLTLKNPVLTASGTVGFGEEYAPYLDLAGLGALVVKTVTLKPRAGNPPPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 +G +N E + + L L R D +I SI GE ++ LA Sbjct: 61 ITETPAGVINAVGLQNPGV--EALVRDILPRLARF-----DVPVIVSIAGETVDEYARLA 113 Query: 121 RLVQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + G +E N SCP + + G G P + R V+ + LP++AK++PN+ Sbjct: 114 GRLDGVPGIAALEVNISCPNVKAG--GIAFGTEPAMTAAVVRQVRENTRLPVIAKLSPNV 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ +ALAA GAD ++ INT+ ++ ID+ ++ + + G SG AV+P+A+ Sbjct: 172 TDIRTIALAAAGAGADALSLINTLSAMV-IDVERRRPL----LGNVFGGLSGPAVRPVAV 226 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ E P+ G+GGI T DA EF+L GA + V T + +A+ Sbjct: 227 RAVWQVYQAVE---LPLIGMGGIMTARDALEFILAGARAVAVGTANLVN-PGAAAAVAAD 282 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 L YL +QG + E+VG A+ Sbjct: 283 LEQYLTEQGIRDINELVGAAHR 304 >UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q0J918_ORYSJ Length = 601 Score = 221 bits (564), Expect = 3e-56, Method: Composition-based stats. Identities = 63/348 (18%), Positives = 115/348 (33%), Gaps = 41/348 (11%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L + G KF NP L++ N E G+G V ++ PR Sbjct: 214 PSVLGLEIWGRKFTNPIGLAAGFDKN-AEAVEGLLGMGFGFVEVGSVTPLPQEGNPKPRI 272 Query: 62 DHLVKEDT--GFIGFKNMEQI----------AEHPLEENLAALRRLKEDYP-----DKVL 104 L + GF + + + +EE ++ D + Sbjct: 273 FRLREHGAVINRCGFNSEGIVVVAKRLGAQHGKRKMEETSSSTSPTTSDVKQGGKAGPGI 332 Query: 105 IASIMGENE------QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEK 158 + +G+N+ + + + + AD + N S P Q +LV+K Sbjct: 333 LGVNLGKNKISEDATADYVQGVHTLSQY-ADYLVINVSSPNTPGLRKLQGRKQLKDLVKK 391 Query: 159 YCRAVKRG-----STLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDL 211 A P+L K+ P++ D+ ++A A DG+ NT S Sbjct: 392 VQAARDEMQWAEDGPPPLLVKIAPDLSKQDLEDIAAVALALRLDGLIISNTTISRP---- 447 Query: 212 NQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEF 271 G SGK + ++ +++M P+ G GG+ + EDA + Sbjct: 448 ---SPADTHPLAQEAGGLSGKPLFDLSTNVLREMYILTR-GKIPLIGCGGVSSGEDAYKK 503 Query: 272 LLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 + GA +Q+ T G ++ + + F++ L Sbjct: 504 IRSGATLVQLYTAFAYGGPALIPRIKKAWKAAGSTGFFETASSKADLM 551 >UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=PYRD_UNCTG Length = 306 Score = 221 bits (564), Expect = 3e-56, Method: Composition-based stats. Identities = 81/279 (29%), Positives = 132/279 (47%), Gaps = 21/279 (7%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + DLS+ F G+K NP +S G YE+ GGVV KT+ + PR Sbjct: 1 MIPDLSVNFAGIKLKNPVLTASGTFGYGYELADLIPLKRLGGVVTKTVTLEPRAGNLQPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + IG +N+ A +EE L L ++ +I S+ G ++ E+ Sbjct: 61 IAEVASGILNSIGLQNIGVRA--FIEEPLEKLNKI-----GVPVIVSVAGVAVGEYVEIV 113 Query: 121 RLV-QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 +++ + G IE N SCP + + D+ L+ R VK+ S +P++AK++P + Sbjct: 114 KILSSQNGVSAIELNLSCPNLKKKIVCHDL----PLMRDVIRGVKKVSRVPVIAKLSPLV 169 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E+AL A+ GADG+ NT ++ ++ + P ++ + G SG +KP+++ Sbjct: 170 TDISELALTAQNAGADGVTLTNTYPAMA---VDIRTFKPKLS--TVKGGMSGACIKPMSV 224 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAAT 278 R + PI G GGI EDA EF+L GA Sbjct: 225 RCVYDAYQ---DIKIPIIGCGGIMMGEDAVEFILAGATA 260 >UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular organisms RepID=PYRD_NATPD Length = 350 Score = 221 bits (563), Expect = 3e-56, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 112/320 (35%), Gaps = 32/320 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L + G FPNP +++ N E+ G+G V + PR Sbjct: 48 PRLRVDAFGQTFPNPVGVAAGFDKN-AEIPDALGALGFGHVEVGGVTAEPQAGNPRPRMF 106 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIM----GENEQQWEE 118 L ++ I + E RL + +I N+ + Sbjct: 107 RLAEDRA-LINRMGFNNDGADIVGE------RLAATDCRVPVGVNIGKSKSAANDDAEAD 159 Query: 119 LARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 + G D N S P QS + +E ++ P+L K++ Sbjct: 160 YQYTYERVADGGDYFVVNVSSPNTPGLREL----QSRDRLESILGTLQDDGASPLLVKLS 215 Query: 177 PNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ D + + + G DGI A NT + G SG + Sbjct: 216 PDLTDAAIEDAIEVVEDLGLDGIIATNTTTKRPASLHSD--------AADEEGGLSGAPI 267 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + ++ + D PI G+GGI+ E A E + GA+ +Q+ TG++ G I Sbjct: 268 TDESTDIVRFIAKRT---DKPIVGVGGIDDAESAYEKIRNGASVVQLYTGLVYEGPTIAR 324 Query: 295 DMASGLSHYLADQGFDSLQE 314 D+ GL L GF S+++ Sbjct: 325 DINRGLLKLLERDGFASVED 344 >UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neorickettsia RepID=Q2GEM2_NEOSM Length = 348 Score = 221 bits (563), Expect = 4e-56, Method: Composition-based stats. Identities = 72/320 (22%), Positives = 115/320 (35%), Gaps = 31/320 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L CG+ F NP +++ N E G+G + T+ SPR L Sbjct: 43 LESRVCGLHFKNPIGIAAGFDKN-AECVTALRRVGFGFIELGTVTLKPQKGNPSPRLFRL 101 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------QQW 116 ++ +GF N + L +L++ L +I G+N + Sbjct: 102 PQDGAIINRLGFNN------KGIAYFLKSLKKAMTHMDLPPLGVNI-GKNAVSSNAVSDY 154 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 LA V AD I N S P S V EL+ AV GS + + K+ Sbjct: 155 ARLAAYVSSV-ADYITLNISSPNTVSLRDMQKVEILEELLIAVKAAV--GSNVRIFIKVA 211 Query: 177 PNIGDMCE--VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ + E + A + GI NT ++ K G SG + Sbjct: 212 PDLAEGAEVGIISLALKHKVAGIIVSNTTIGCRESLHSK--------HKVEYGGLSGTPL 263 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 ++ +++M + G GGI E A + GAA +Q T +G+ ++ Sbjct: 264 FKLSTGLLRKMYRCT-NGELVFIGCGGISDAETAYAKIRNGAALIQAYTSFTYHGFGLLN 322 Query: 295 DMASGLSHYLADQGFDSLQE 314 + L L GF S+ E Sbjct: 323 QIKKDLVQRLKADGFSSVSE 342 >UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D3W9_DESK1 Length = 302 Score = 220 bits (561), Expect = 6e-56, Method: Composition-based stats. Identities = 90/318 (28%), Positives = 151/318 (47%), Gaps = 18/318 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + + L + G++ +P +S +G+ E G+ +V KTI P Sbjct: 1 MVEVLETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 +V+ G N +A + L R + K LI SI G + +++ +LA Sbjct: 61 --IVELRNN--GLLNAVGLANPGA-RVIPVLARKARELS-KPLILSIGGSSVEEFVKLAE 114 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 L EAG D +E N SCP G ++G P LV + + ++LP++AK+ Sbjct: 115 LASEAGVDAVELNLSCPHAEG--YGLELGSDPMLVYRIVKDAVSVASLPVIAKLGL-TDR 171 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E A A G + INTVK+++ ++ P+++ K G SG + PIA+R Sbjct: 172 VIESAGKALEAGVKALTLINTVKAMS---IDVYTLKPVLSNK--YGGLSGPPIHPIAVRV 226 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + + I G+GG+ +W D AE +L GA +QV T ++ IV+++ SGL Sbjct: 227 VYDVYREYRAE---IIGVGGVSSWMDVAELILAGARAVQVGTALIWN-ENIVDEILSGLH 282 Query: 302 HYLADQGFDSLQEMVGLA 319 +L D G++SL ++VG+A Sbjct: 283 KWLIDLGYNSLMDLVGIA 300 >UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10 Tax=Proteobacteria RepID=Q3J7C7_NITOC Length = 331 Score = 220 bits (561), Expect = 7e-56, Method: Composition-based stats. Identities = 80/314 (25%), Positives = 133/314 (42%), Gaps = 18/314 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCA--KAYDTGWGGVVFKTIGFFIA-NEVSPR 60 L + FCG++ +P L S VG E + G V K R Sbjct: 15 ARLKVDFCGLELQSPLVLLSGCVGFGEEYTRVVGFSNREVGAVCLKGTTAAPRLGNALHR 74 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 IG +N ++ ++ L AL D+ + IA++ G +++ + Sbjct: 75 IYETPMGMLNAIGLQNPGV--DYVVDHILPAL-----DFSETRYIANVSGSTIEEYTAVT 127 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 R + D IE N SCP + G G P + + A ++ + P++ K++PN Sbjct: 128 RRFDNSPIDAIEINISCPNVKEG--GVAFGNDPHMSARVVEACRKVTRKPLITKLSPNQT 185 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + E A G DG A INT+ + ID+ Q+ + + G SG A+KPIAL Sbjct: 186 SIEENARRCIEAGTDGFAVINTLMGMA-IDIEQRTPLLG----NIQGGLSGPAIKPIALL 240 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 ++Q+ PI G GG+ + +DA EFL+ GA T+ V T + Y + + + + Sbjct: 241 KVRQVYQACRAHGIPIIGQGGVASGKDALEFLIAGATTVGVGTALF-YDPLLCAKINAEI 299 Query: 301 SHYLADQGFDSLQE 314 YL ++ + Sbjct: 300 VAYLKRHDLRAVAQ 313 >UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R4R9_9RHOB Length = 367 Score = 220 bits (560), Expect = 9e-56, Method: Composition-based stats. Identities = 68/332 (20%), Positives = 124/332 (37%), Gaps = 31/332 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L + F NP +++ N E G+G V T+ PR L Sbjct: 47 LEYKLGDLTFKNPVGMAAGFDKN-AEAITPLMKLGFGHVEVGTVTPLPQEGNPKPRNFRL 105 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------QQWEE 118 D I + E R+++ ++ +G N+ + Sbjct: 106 -SADRAVINRYGFNNDGHDVVYE------RIRKAGRTPGVLGINVGANKLSEDRVADYVL 158 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----KRGSTLPMLA 173 + E AD + N S P + L+ A + G +P++ Sbjct: 159 GVKRFAEL-ADYLTANISSPNTPGLRDLQEKDALAHLLSAIVNARDEQEDRLGRKVPVML 217 Query: 174 KMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P++ + + E+A DG+ NT + + +Q+ G SG Sbjct: 218 KIAPDVTEEALKEIAEVVMTNKVDGMIVSNTTIARPSTLKDQQQAE-------EAGGLSG 270 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + A + + R D P+ G+GG++T E AA + GA +Q+ +G++ G Sbjct: 271 APLFERATIALAKTRRAVG-PDLPLFGVGGVDTPEKAAAKIFAGANQIQLYSGMVYEGQT 329 Query: 292 IVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 +V+ + LS +A +G +LQE+VG+ N+ Sbjct: 330 LVKKINKHLSRLVAARGVSNLQELVGIDNDIW 361 >UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsiales RepID=B3CMR9_WOLPP Length = 355 Score = 219 bits (559), Expect = 1e-55, Method: Composition-based stats. Identities = 64/333 (19%), Positives = 131/333 (39%), Gaps = 39/333 (11%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 L K L++ F G K +P L++ N E+ G+G + T+ PR Sbjct: 48 LPKSLNVNFFGNKIRSPVGLAAGFDKN-AEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPR 106 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN------ 112 L+K++ +GF N ++ L + K + +G N Sbjct: 107 IFRLIKDEGIINRLGFNN------KGVDYFLKQISETKLGNC---IFGINIGRNSTSKDQ 157 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYC---RAVKRGSTL 169 + +L ++V ++ I N S P + + + +L++ +++ ++ Sbjct: 158 ISDYVDLIKIVYG-KSNYIVLNISSPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESI 216 Query: 170 PMLAKMTPNIGDM--CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P++ K++P+I +A DG+ NT S + + Sbjct: 217 PIILKISPDIDQQTKENIAELTLEYKIDGLIVSNTTISRDSYY-------------NESG 263 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ + ++ + M + + G GGI + DA E + GA+ +Q+ T ++ Sbjct: 264 GLSGRPLFQLSTELLSDMYKLTKS-RILLIGCGGISSGVDAYEKIKAGASLVQLYTALVY 322 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLAN 320 G+++V + L+ + GF ++ E VG + Sbjct: 323 QGHQVVNKINLELAELVKRDGFSNITEAVGCIH 355 >UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Rickettsiales RepID=B9KHW9_ANAMF Length = 389 Score = 219 bits (558), Expect = 1e-55, Method: Composition-based stats. Identities = 59/327 (18%), Positives = 131/327 (40%), Gaps = 33/327 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + + LSI C ++F P L++ N E+ G+G V T+ PR Sbjct: 75 MPECLSIEVCHLRFRTPIGLAAGFDKN-AEVIKPLIGMGFGFVEAGTVTKKPQSGNKRPR 133 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN------ 112 +V + +GF N ++++ + ++ + +G N Sbjct: 134 LFRIVDQKAVVNRLGFNNKGIQ---------RFIKKIDRKELNNLVFGANLGINKTCTDP 184 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK---RGSTL 169 ++ E+ R V + I N S P + G E++ A + + ++ Sbjct: 185 PAEYAEMVRSVYGL-SSYITINVSSPNTAGLRDLQNRGPLSEILSSVRDARRSVDQAESV 243 Query: 170 PMLAKMTPNIGDMC--EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+ K+ P+I D ++A + G+ NT ++ + ++ N + Sbjct: 244 PIFLKIAPDISDELKQDIAEEIVKHKISGLIVSNTTTDLSLLGKDR-------NKSITQG 296 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG+ + ++ + +M + + + G GG+ + A + + GA+ +Q+ T ++ Sbjct: 297 GLSGRPLFDLSTTVLSEMYSLLRDKVI-LIGCGGVSSGAQALQKIKAGASLVQLYTALVY 355 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQE 314 G+ +V+ + L+ L +GF +++ Sbjct: 356 EGFGVVKKINMELAELLTQEGFSKVEQ 382 >UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobacterales RepID=PYRD_SULDN Length = 352 Score = 219 bits (558), Expect = 2e-55, Method: Composition-based stats. Identities = 68/322 (21%), Positives = 125/322 (38%), Gaps = 40/322 (12%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHL 64 L G F NP L + N M G+G TI A PR Sbjct: 51 LKQELFGRTFFNPIGLGAGFDKN-ATMIRAMQILGFGFTEIGTITPKAQAGNPKPRMFRH 109 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------Q 114 ++E + +GF N ++ +RLK+ +P I +G+N+ Sbjct: 110 IEEQSIQNAMGFNNEGLLSAQ---------KRLKKRFPFTTPIGINIGKNKLTPDTQAIN 160 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 + L + + E G D + N S P Q+ E + K K ++ P+L K Sbjct: 161 DYTTLIKALHELG-DYLVINISSPNTPGLRDL----QNEEFITKLFEESKAITSKPILLK 215 Query: 175 MTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D + A GADGI A NT +V SI G SG Sbjct: 216 IAPDMSKEDAVALTKLAVLKGADGIIATNTTVD-----------YSLVKEPKSIGGLSGA 264 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 +K + + + + + +GGI + ++ + GA+ +Q+ +G++ G + Sbjct: 265 VLKEKSFEIFEAVAKELYGKT-TLISVGGISSAKEVYRRIKAGASLVQIYSGLIYEGPDL 323 Query: 293 VEDMASGLSHYLADQGFDSLQE 314 ++++ + L+ + G+ ++ + Sbjct: 324 IKNINNELTELIKADGYTNITQ 345 >UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus cereus RepID=C2QE06_BACCE Length = 350 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 68/334 (20%), Positives = 120/334 (35%), Gaps = 35/334 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L +KFPNP L++ ++ G+G V +I PR Sbjct: 36 SRLECKLLDIKFPNPIGLAAGFDKF-ADVYPGLASLGFGSVEVGSITPKPQSGNPKPRLY 94 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQ-------- 114 L + DT I ++N L R P+ L ++ G+N+ Sbjct: 95 RLPE-DTALINRMGFNSEGLDRAKQNFMTLPR-----PNIPLGINL-GKNKDTPNSDATL 147 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----KRGSTL 169 +++ + G D N S P V L+ K Sbjct: 148 DYQKGLETLYSYG-DYFVINISSPNTEGLRDLQYVDTLKPLLASILDKRNELCKKHNQYR 206 Query: 170 PMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P++ K+ P++ + V + D + A NT S TN++ + Sbjct: 207 PIILKIAPDLTPEQLEGVISIIQEVKIDAVIAANTTISRTNLNS---------KFQKQNG 257 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SGK + + I ++ + + PI G GG+ T EDA E + GA+ +Q+ T ++ Sbjct: 258 GLSGKPLNHRSTEIISKIYRQTQ-GNLPIIGSGGVFTGEDAYEKIKSGASLIQIYTSMIY 316 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 G + + + + L G ++ E +GL + Sbjct: 317 RGPSVAKHINQEILTLLEKDGLTNITEAIGLYHK 350 >UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_SYNY3 Length = 381 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 117/324 (36%), Gaps = 25/324 (7%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFD 62 L T G+ FPN LS+ E A G+G + PR Sbjct: 58 PRLQQTCWGLNFPNVLGLSAGCDKEG-EAAAVWPALGFGFAELGAVTKYAQPGNDRPRLF 116 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 L ++ +G N +A L+ + YP + I + +++ Sbjct: 117 RLPQDQAVLNRLGANNEGAVAMAA------KLKHTWDYYPRTIPIGINLCKSKITPLDQA 170 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 + + + + AD N S P + + P + A P+L Sbjct: 171 VEDYVFSFQTLAPV-ADYFVVNVSSPNTPGLRSLQESDELPRIFAGLQSA--NHWQKPLL 227 Query: 173 AKMTPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K++P+ + + K GI A NT + + + + + G S Sbjct: 228 VKISPDLSWEAIAVIIDLVKEHNLSGIVATNTSTRRSGLK-TKILPQTGQPIEQEAGGLS 286 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G+ ++ A I+ + PI G+GGI T EDA E + GA+ LQ+ TG + G Sbjct: 287 GQPIRDRATEVIRYIYQQTG-GTIPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGGP 345 Query: 291 RIVEDMASGLSHYLADQGFDSLQE 314 +V D+ GL LA GF + E Sbjct: 346 WVVSDILQGLGEKLAAGGFSHISE 369 >UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G8S8_PHATR Length = 456 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 76/352 (21%), Positives = 134/352 (38%), Gaps = 38/352 (10%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFDHLV 65 S + G FPNP L++ + E+ + D G+G V T+ PR LV Sbjct: 92 SNSVFGKTFPNPIGLAAGFDKDG-EVVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRLV 150 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRR------------------LKEDYPDKVLIAS 107 + D G I +E+NL + R L L+ Sbjct: 151 E-DLGIINRYGFNSQGASTVEKNLKSFRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVGV 209 Query: 108 IMGENEQQWEELARLVQEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA 162 +G+N+ + + V AD + N S P L+ Sbjct: 210 NIGKNKNSLDAIGDYVCNIRQLSSLADYMVLNISSPNTAGLRDLQQANSLRVLLTTCLTT 269 Query: 163 VKRGST-LPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 + +P+L K+ P++ D + ++A G DGI NT L++ Sbjct: 270 RNEMTHRVPLLVKLAPDLTDEELDQIANVCLEVGIDGIIITNTTNHRPADLLSK------ 323 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 + I G SGK VK + I+++ PI G+GG+ + DA E L GA+ + Sbjct: 324 --HRGEIGGLSGKPVKDQSTECIRRLFRLT-DGKIPIIGVGGVGSGHDAYEKLKAGASLV 380 Query: 280 QVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDR 331 QV + ++ G ++ + L+ + + G S+ +++G + +I + +R Sbjct: 381 QVYSMMVYQGPGVISRIRHDLATLMLENGQRSIVDVIGADHEDIFWRKREER 432 >UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular organisms RepID=PYRD_SYNPX Length = 396 Score = 217 bits (553), Expect = 6e-55, Method: Composition-based stats. Identities = 72/329 (21%), Positives = 122/329 (37%), Gaps = 20/329 (6%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 L G +FPNP L++ N G+G T+ + PR Sbjct: 68 RLEQVLFGCRFPNPVGLAAGFDKNGV-AAGLWDRFGFGFAEVGTVTWHGQPGNPRPRLFR 126 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQ 115 L ++ + L L +RL ++ +G++ + Sbjct: 127 LA-QEQAALNRMGFNNDGAQALRRTLER-QRLAPPGRRPAVLGINVGKSKVTALEQAPED 184 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 + L+ AD N S P D Q LVE R + + P+L K+ Sbjct: 185 YASSLELLAPL-ADYAVINVSSPNTPGLRDLQDSSQLRRLVE---RLRRLPACPPLLVKI 240 Query: 176 TPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D + +A A G G+ A+NT ++ +++ G SG Sbjct: 241 APDLEDEAIDGIARLAFEEGLAGVIAVNTSLDRLGLE-QRRLLQTGRTLAEEAGGLSGAP 299 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 ++ AL I+++R + G+GGI++ E A E + GA+ +Q+ TG + G +V Sbjct: 300 LRQRALEVIRRLRASAG-PALTLIGVGGIDSAEIAWERITAGASLIQLYTGWIFQGPELV 358 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNN 322 + GL L G S+ E VG Sbjct: 359 PRILEGLQLQLDRHGLRSIAEAVGSGLPW 387 >UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4J6_GEMAT Length = 327 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 67/311 (21%), Positives = 125/311 (40%), Gaps = 18/311 (5%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 S++ G+ F NP L+S G E+ + GG+ K + + R Sbjct: 23 SVSVAGLAFRNPVVLASGTAGFGQELEDVLDLSAVGGISTKAVSVAPRPGNPALRVSEFA 82 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 IG N + L L +P + +++G + + + + R + + Sbjct: 83 GGMMNAIGLANPGLESVRR-----DYLPWLPAHHPGTRVFVNVVGNSIEDFATVVRGLDD 137 Query: 126 A-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG-DMC 183 G D E N SCP + + G + G P+ + A + + P+ K++P +G + Sbjct: 138 VPGVDAFELNVSCPNVKAG--GLEFGADPQALHALVSAARGATKRPIFVKLSPTLGAAIA 195 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 + A A GA G+ +NT + ++ P ++ G SG A+ P+ L Sbjct: 196 DTARVAVDAGATGLTLVNT---MPGTVIDTDRRRPKLSF--GSGGVSGPALLPVGLLATW 250 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ P+ G+GGI T +DA ++L+ GA+ + V T + R E + L + Sbjct: 251 RVSRAL--PTVPLIGLGGISTGDDALQYLMAGASLVGVGTAAL-RDPRAPERIVRQLQRW 307 Query: 304 LADQGFDSLQE 314 +G + Sbjct: 308 CDREGVRDITT 318 >UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2EKA7_TRIVA Length = 365 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 99/396 (25%), Positives = 152/396 (38%), Gaps = 37/396 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 L F G + NP + P + C G G +V KTI A P Sbjct: 1 MSLKTKFAGYEVKNPLMPAPGPPVRDAKACIDCIKGGCGVMVTKTISVAAAKVPQPNMYE 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPD---KVLIASIMGENEQQWEELA 120 F N E E E+ L + + +I S MG ++ ++A Sbjct: 61 SKDHKY----FLNTELWTELTPEQWLEHEYPKIREVCNQAKIPMICS-MGYTAEEIAKMA 115 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVE-KYCRAVKRGSTLPMLAKMTPNI 179 V D +E +G P+ ++ A+ P+ K++P Sbjct: 116 PKVAPF-CDGLEL-----------STHYIGDDPKPMQDAIKAAIHGSGGKPVYVKLSP-F 162 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D A AAK GA G+ +N+ +D+ + G P + S SG A+KP+AL Sbjct: 163 RDAPIAAKAAKAAGATGLVCVNSFGPTLALDIE-RKGAPFMGSTSKYGWVSGPAIKPLAL 221 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + + + D P+ G+GGI DA EFL+ GA L + T + G + +A Sbjct: 222 RVVYDV---CKEVDLPVVGVGGISNGRDAIEFLMAGAQALGICTAAIVEGRDVYGSIAQE 278 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGH 359 +S +L + G+ + E++GL + + I +KCVGCG C SC Sbjct: 279 MSQWLTEHGYKDIHEVIGLGLKHEPLQQHNPPK------IAAEKCVGCGTCVTSCLYEAL 332 Query: 360 QAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIEL 395 Q + C+ KC C LC CP I + Sbjct: 333 QL-----EDGIAKCDGAKCFRCGLCYTRCPTCAISI 363 >UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A1L2_THESM Length = 309 Score = 217 bits (552), Expect = 8e-55, Method: Composition-based stats. Identities = 93/322 (28%), Positives = 151/322 (46%), Gaps = 21/322 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + DLSI G+KF NP L+S PVG +E+ + G + KT+ PR Sbjct: 1 MGVDLSIDVFGIKFRNPIILASGPVGFGFELMPYLDFSNIGAITLKTVTLKPREGNPPPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 IG +N +EE L+ LK I SI G + +WE L Sbjct: 61 LVDSHGGVINSIGLQNPGIEG--FVEEIAPRLKELKTIK-----IGSIAGFSMDEWEILG 113 Query: 121 RLVQ-EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + +IE N SCP + ++ +L EK + V++ + P++AK+ P++ Sbjct: 114 EEMDKIKEIKIIEINLSCPNVKGKRRWAE---DAKLTEKVVKIVRKLTGKPIIAKLAPDV 170 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ E+A A GADG+ N +++ ++ + G+PI+ K+ G G AVKPI L Sbjct: 171 TDIVEIAKTAVDAGADGLTIGNGAQAMR---IDVETGLPILKLKT--GGLGGPAVKPITL 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + + R D PI GIGGI W+DA E+ + GA+ L + T +M + G Sbjct: 226 AKVFKTREAL---DVPIIGIGGIMNWQDAIEYAMAGASLLGLGTAVMV-DPEAPVRIIEG 281 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 + +L + +S +++G+A+ Sbjct: 282 IKAFLERKKIESFNKIIGVAHK 303 >UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=Q1V0W4_PELUB Length = 350 Score = 216 bits (551), Expect = 1e-54, Method: Composition-based stats. Identities = 67/320 (20%), Positives = 119/320 (37%), Gaps = 31/320 (9%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFDHLV 65 G NP +++ N E+ + G+G V T+ PR LV Sbjct: 44 KTNLFGKNIDNPIGMAAGFDKN-AEVYNPLFKLGFGFVEVGTVTPLEQYGNPKPRVFRLV 102 Query: 66 KEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 ++ +GF N+ + K L+ +G N+ + L + Sbjct: 103 EDQALINRLGFNNLG----------AENISHRIRSNSHKGLLGINIGPNKDSEDRLNDYL 152 Query: 124 QEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRA-VKRGSTLPMLAKMTP 177 AD I N S P + D + EL+ + VK S +P++ K++P Sbjct: 153 IGLRNFYDIADYITVNISSPNTENLRAFHDETKFDELLNAIEKEKVKLKSKIPIVVKISP 212 Query: 178 NIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVK 235 +I D + ++ + I NT + K G SGK ++ Sbjct: 213 DISDEQIELISKILIKHKVSAIIVSNTTA--------KNREKLNNILKHQKGGLSGKPLE 264 Query: 236 PIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVED 295 A + I + + I G+GG+++ E A + GA+ +Q+ TG++ G IV Sbjct: 265 EEANKLISKFYKLLK-GKIEIIGVGGVDSGESAYKKFQAGASYVQLYTGMVFQGPNIVGK 323 Query: 296 MASGLSHYLADQGFDSLQEM 315 + L L D+G + +E+ Sbjct: 324 IKKELKEILIDEGIKNFKEI 343 >UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria RepID=PYRD_VEREI Length = 360 Score = 216 bits (551), Expect = 1e-54, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 109/328 (33%), Gaps = 28/328 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRF 61 T D I G++FPN L++ N G+G V T+ PR Sbjct: 45 TVDDPIELAGLRFPNRVGLAAGLDKN-ARCIDALGAMGFGFVEAGTVTPQAQPGNPRPRM 103 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE---- 117 L + I NL R + + +G+N Sbjct: 104 FRLPEARA-LINRLGFNNAGLQAFVHNLQQSRLRAAGSALR--LGLNIGKNASTPMAQAS 160 Query: 118 -ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGSTL 169 + ++ AD + N S P + L+ A + G + Sbjct: 161 SDYLACLEGVYPHADYVALNISSPNTQNLRTLQGDAALDHLLGAIAERRATLAARHGRRV 220 Query: 170 PMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 P+ K+ P++ + + +A +R G DG+ A NT + Sbjct: 221 PVFVKIAPDLDEAQLSLMAATLQRHGIDGVIATNTTIDRAVV--------QGQRHAQESG 272 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG V + + I Q+R FPI G+GGI + EDA + GA +Q+ TG++ Sbjct: 273 GLSGAPVLQASNQVIGQLRAALGKG-FPIIGVGGIMSAEDAVSKIRAGADLVQIYTGLIY 331 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEM 315 G +V A + +L Sbjct: 332 EGPALVVQAARAIKAMGGCGPVIALPNR 359 >UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_LACBS Length = 499 Score = 216 bits (550), Expect = 1e-54, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 119/320 (37%), Gaps = 31/320 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L+ G + NP L++ + E ++ G+ V ++ PR Sbjct: 107 ARLNCQIWGQEASNPVGLAAGFDKDG-EAIDGLFELGFSWVEIGSVTPKPQPGNPRPRVF 165 Query: 63 HLVKEDT--GFIGFKNMEQIAEHP-LEENLAALRRL--KEDYPDKVLIASIMGENEQQWE 117 HL ++ + GF + + + + + + L+A +G+N++ Sbjct: 166 HLPEDSSLINRYGFPSQGHASVLSRIRSRIPPFTSGPNRASLREGCLLAVNLGKNKESPA 225 Query: 118 E----LARLVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--- 168 + V+ G D++ N S P + L++ +A S Sbjct: 226 DSIDDFVTGVRTFGPYSDVLVVNVSSPNTPGLRGLQNRDVLERLLDGVTKARDELSPSVL 285 Query: 169 ---LP-MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 P ++ K P++ ++ ++A + DG+ NT +N Sbjct: 286 TFRKPKLVLKFAPDLNESELADIADVIRNSSIDGVIVSNTTVQRPKSLVN--------PN 337 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 KS + G SG VKP++L+ ++ +R H P+ G GGI T DA EF GA+ +QV Sbjct: 338 KSEMGGLSGPPVKPLSLKALRILRGHLPA-SIPLIGCGGISTGADALEFAKAGASMVQVY 396 Query: 283 TGIMQYGYRIVEDMASGLSH 302 TG G + + Sbjct: 397 TGFGYDGVGACRRIKDQVVD 416 >UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhabditis RepID=A8WW30_CAEBR Length = 426 Score = 216 bits (550), Expect = 1e-54, Method: Composition-based stats. Identities = 67/352 (19%), Positives = 129/352 (36%), Gaps = 43/352 (12%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 +L G +F NP L++ + + A ++G+G + ++ PR Sbjct: 88 PELKCELFGREFRNPIGLAAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNNRPRVF 147 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L++++ G I + + + + R ++ G+N+ E A+L Sbjct: 148 RLLEDE-GVINRYGFNSDGVGRVHQRVRSARDAWVPEQYAYFGVNL-GKNK--LTEDAKL 203 Query: 123 VQEAG-------ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK--RGSTLP-ML 172 E G D + N S P +L+ ++ + P + Sbjct: 204 DYEIGVNYFAPHCDYLVLNVSSPNTPGLRSMQKKSDLEKLLAYVKESLDMHKLEKRPQIF 263 Query: 173 AKMTPNI--GDMCEVALAA--KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 K+ P++ +M ++A K+ G DGI NT + + ++ K+ G Sbjct: 264 LKIAPDLIDSEMKDIAHVVTNKKFGVDGIIVSNTTIARPDYLKSE--------NKAETGG 315 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLL--------------- 273 SG V+ I+ I++M PI G GG+ + EDA E + Sbjct: 316 LSGAPVREISTECIRKMYKLT-NGQIPIIGCGGVFSGEDAYEKIRYNRRNAIDSNYNIFS 374 Query: 274 LGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVP 325 G + +Q+ + + G+ ++ + LS L GF + E VG + Sbjct: 375 AGGSLVQLYSAFVYEGFPVIGKIKRELSELLKRDGFAHVSEAVGADHRPKQN 426 >UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodospira halophila SL1 RepID=PYRD_HALHL Length = 342 Score = 216 bits (550), Expect = 1e-54, Method: Composition-based stats. Identities = 59/315 (18%), Positives = 109/315 (34%), Gaps = 35/315 (11%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVKE 67 G+ FPNP L++ + E G+G + T+ PR + + Sbjct: 46 RVMGIDFPNPVGLAAGFDKDG-EYMDVLEQLGFGFLELGTVTPRAQPGNPQPRVFRIPEH 104 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQWEEL 119 + I PL L R + ++ +G+N + + + Sbjct: 105 EA-LINRMGFNNQGAEPLVRRLEVSRH-------RGVVGINIGKNRDTPPERAVEDYAQA 156 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLPMLAK 174 +V AD + N S P G L+++ KR + +P++ K Sbjct: 157 LGMVYGV-ADYVAVNLSSPNTPGLRDLQHEGALRNLIDRLQTERKRLAELHDKRVPLVVK 215 Query: 175 MTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P+ ++ DGI A NT T ++ + G SG Sbjct: 216 IAPDWEAGELDATLDILLERRVDGIVATNTTLGRTGVEQTPQ--------ARESGGLSGA 267 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 ++ A ++Q+ R + GGI + ED L LGA +Q+ TG++ G + Sbjct: 268 PLREQAEWVLEQVAAR-RDRRTALIAAGGIMSGEDVTRRLDLGADLVQLYTGMIYRGPGL 326 Query: 293 VEDMASGLSHYLADQ 307 V++ + + Sbjct: 327 VQEAVRAAARHAGQP 341 >UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobacteria RepID=PYRD_COXB1 Length = 347 Score = 216 bits (550), Expect = 1e-54, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 121/309 (39%), Gaps = 39/309 (12%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVK 66 G++FPNP L++ N E + G+G + + PR L + Sbjct: 47 TVVFGIEFPNPVGLAAGLDKNG-EYMDELLGLGFGFIEVGAVTPKPQPGNSKPRIFRLPQ 105 Query: 67 EDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQW 116 +GF N+ ++ + L+R K K ++ +G+N + + Sbjct: 106 ARALINRMGFNNL------GVDYLVEQLKRRKV----KGIVGVNIGKNLTTPLEKAHEDY 155 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-----LPM 171 + + D + N S P +L+ + +R +P+ Sbjct: 156 QNCFEKLYSY-VDYVTINISSPNTPELRQLQSERYLADLLTRLKEDQRRLEDQYHKRVPL 214 Query: 172 LAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ ++ +A A + +GI A NT S G + + G Sbjct: 215 FLKIAPDLTPEEIQTIATLALQHRIEGIVATNTSCSR--------QGTEKLPNANEAGGL 266 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + P+ L+ ++Q+ + + PI +GGI + E+A + GA +Q+ TG++ G Sbjct: 267 SGKPLFPMTLQVVKQLHSFLGD-EIPIVAVGGIFSGENAQTLINAGARLVQLYTGLIYEG 325 Query: 290 YRIVEDMAS 298 +V+++ Sbjct: 326 PELVKNIVE 334 >UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5A0_9ALVE Length = 471 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 68/329 (20%), Positives = 114/329 (34%), Gaps = 24/329 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNC-YEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDH 63 L GV+FP P L++ N + G G ++ PR Sbjct: 136 LKQVLFGVEFPRPVGLAAGFDKNGELLHLLTSSTLGNGFAEIGSVSKEPWPGNPRPRMFR 195 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQ-------QW 116 L D I + L E L ++ L I + + Sbjct: 196 LA-RDGAVINRMGLNNRGAAALREKLRSMSTLLNGTRHTPPIGVSITKTPSPTIENDAAI 254 Query: 117 EELARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLA 173 ++ E A I+ N SCP D+ +L+ + P+L Sbjct: 255 ADIVASFDEVAPYAAYIDVNISCPNTAEGKTFEDLEALEKLLGALLTWRRDNYPDKPVLV 314 Query: 174 KMTPNIGDMCE--------VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 K++P + + + A G DG INT+ + + +G Sbjct: 315 KLSPPPAEADDTYYEGVSRMVRKAVELGVDGFVMINTIADRGDDLNLDRSVGDSNHG--E 372 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SGK V+ A+ ++ + PI G GG+ T +DA + GA+ +QV TG+ Sbjct: 373 KGGISGKPVRQRAINLVRHVYKVT-AGKVPIIGCGGVFTAQDAYRLIRNGASLIQVYTGM 431 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQE 314 + G + D+ GL+ L G+ ++ E Sbjct: 432 IYEGPWVFRDINCGLAELLRKDGYSNVHE 460 >UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_ANASP Length = 343 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 128/341 (37%), Gaps = 19/341 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL+ + G++ +P S+SP+ + D G VV ++ + S H Sbjct: 1 MDLTTNYLGLRLRSPLVPSASPMSGEIDNILWMEDAGAAAVVLPSLFEEQLSLESYELHH 60 Query: 64 LVKEDTGF----IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + T + + Q EE L +++ KE +IAS+ G + W E Sbjct: 61 HLTYGTESFPESLTYFPEHQDFRLGSEEYLNLIQKTKEKVK-IPIIASLNGSSLDGWTEY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 AR++++AGA +E N + QS + VK +P+ K++P Sbjct: 120 ARMIEQAGAAALELNTYSVHTDPELTSEQIEQSY---INMLKVVKASVQIPVAIKLSPYF 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 +M +A GAD + N +I+L P V S + L Sbjct: 177 TNMANMAKRLDDAGADALVLFNRFYQ-PDINLETLEVQPHVL-------LSTPQAMRLPL 228 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I + H ++ GI D + L+ GA + + ++++G + + Sbjct: 229 RWIAILYGHINAH---LAATSGIHNGHDVLKMLMAGANITMLCSVLLRHGIDHIRCIEQE 285 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 +S ++ ++S+Q++ G + P + Sbjct: 286 MSQWMEKHEYESVQQLQGSMSQKHCPNPSAFERAQYMRALQ 326 >UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8W8_WEIPA Length = 323 Score = 214 bits (545), Expect = 5e-54, Method: Composition-based stats. Identities = 76/332 (22%), Positives = 134/332 (40%), Gaps = 18/332 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 M + +++ G+K NPF SS + G +V KT P Sbjct: 1 MNDERYAVSLPGLKLKNPFMPSSGAFYYGLDHMDDFDLNKLGALVLKTTTLAPRTGNPQP 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + +G N A L L PD + SI G ++ +L Sbjct: 61 WIVNTKAGILNSVGLANPGIAAVKA-----DFLPELAAKLPDLPKMLSISGATVDEFVQL 115 Query: 120 ARLVQEAGA-DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A+++ + A + IE N SCP + G G + + AV+ +T + AK++PN Sbjct: 116 AKIIDKLPAINAIELNLSCPNVDEG--GCAFGVTESGIHSVVSAVRAVTTKAIYAKLSPN 173 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ +A+ A+ GADG+ +NT+ ++ +DL + G SG+A+ P+A Sbjct: 174 VTDIKPLAVTAENAGADGLTMVNTLVGMS-LDLQSRSARLY----RGKGGLSGEALHPLA 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 + I + + PI G+GG+ + +DA E ++ GA+ +QV + + + Sbjct: 229 VELIWEAASAV---HIPIIGVGGVSSIDDALELMMAGASAVQVG-VMNSIDKLCLPKLID 284 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLD 330 L L FD + ++ D Sbjct: 285 ALPAALDKYHFDKVSDVTNALRALPENEHDWQ 316 >UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanobacteria RepID=A8ZNQ0_ACAM1 Length = 339 Score = 214 bits (545), Expect = 5e-54, Method: Composition-based stats. Identities = 60/337 (17%), Positives = 124/337 (36%), Gaps = 20/337 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSS-PVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS T+ G + +P + + P+ + D G +V ++ + F Sbjct: 1 MDLSTTYLGTRLRSPLVVGACAPLSEKIDHLRHMEDAGAAAIVLHSLFEEQLRQDRLGFH 60 Query: 63 HLV----KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 H + + + + + E+ L + + K D +IAS+ G W Sbjct: 61 HHLTHGTESFAEALSYCPEPDVFHVGPEQYLEHIHQAKAIV-DTPIIASLNGATIGGWTN 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A+ ++EAGAD +E N G+++ QS V +P+ K++P Sbjct: 120 YAKKIEEAGADALELNIYTVPTEMAIAGAEIEQSY---IDIVHTVTSTVNIPVAIKLSPF 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 ++ +A G +G+ N +ID+ P + S + Sbjct: 177 FSNLAYMAKRLTDAGVNGLVLFNRFYQ-PDIDIETLEVRPNLL-------LSTPQDIRLP 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR+I + + GI T D + +++GA + + ++++G + + Sbjct: 229 LRWIAILYGTLP---VDFAATSGIHTAADVLKMMMVGANATMLVSVLIRHGIDHLRTLEH 285 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV 335 L +L + ++S+Q++ G + P Sbjct: 286 ALCQWLKEHEYESIQQLQGSMSQVNCPDPSAFERVQY 322 >UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SB76_9ACTO Length = 377 Score = 214 bits (544), Expect = 5e-54, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 104/295 (35%), Gaps = 32/295 (10%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVKE 67 T GV+FPNP L++ N + G+G V T+ PR L Sbjct: 96 TVFGVRFPNPVGLAAGMDKNGLALP-AWPALGFGFVEVGTVTAHAQPGNPRPRLFRLRDS 154 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQWEEL 119 + I L + LAAL R L S+ G+++ + + Sbjct: 155 EA-VINRMGFNNAGAEALADRLAALPR----PLGVPLGISL-GKSKVTPLDEAVEDYLAS 208 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 R +++ G D N S P D L+ P+L K+ P++ Sbjct: 209 YRALKDHG-DYFAVNVSSPNTPGLRSLQDRSHLDALLAALVGE------KPVLVKIAPDL 261 Query: 180 GD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + E+ GA G+ A NT + + + + G SG+ + Sbjct: 262 TEPAVAELLEVCLDRGAAGVIATNTTLARDGLAPADRER------AAEAGGLSGRPLTAR 315 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 A + + P+ G+GGI +DA GA+ LQ+ TG + G + Sbjct: 316 AREMVAFVHRETG-GRLPVIGVGGILHPDDATRMFDAGASLLQLYTGFIYRGPAL 369 >UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=PYRD_AKKM8 Length = 348 Score = 214 bits (544), Expect = 5e-54, Method: Composition-based stats. Identities = 61/318 (19%), Positives = 113/318 (35%), Gaps = 36/318 (11%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVK 66 + G+KFPN L++ + + G+G V T+ PR L+ Sbjct: 50 VEILGMKFPNRVGLAAGMDKE-ADTVSAFGQAGFGFVEVGTLTPRPQPGNEKPRLFRLIP 108 Query: 67 EDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEEL 119 + +GF N A + ++ ++ +G+N+ ++ Sbjct: 109 QKAIINRMGFNNEGIAAG---------VENIRSATRFHGVLGVNIGKNKITPNEDAAQDY 159 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGSTLPML 172 ++ A AD I NFS P + L+ A + G +P+ Sbjct: 160 LTCLRAAWPVADYIAINFSSPNTPGLRDLQAAEPAARLLASLKSEQSNLAAETGRHVPIF 219 Query: 173 AKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ D + E++ G DG+ A NT S ++ N + G S Sbjct: 220 MKVAPDVTDEHIAELSRVFLDEGLDGLIATNTTLSRVGVEANPRHE--------EAGGLS 271 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G + + I + + PI G+GGI DA + GA+ +Q+ TG + G Sbjct: 272 GAPLTERSTEVIGAFASELK-GRIPIIGVGGIMNGVDAVAKIKAGASLVQLYTGFVYRGP 330 Query: 291 RIVEDMASGLSHYLADQG 308 ++ + + Sbjct: 331 DLIRECVEAMKAECPVHR 348 >UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria RepID=PYRD_PETMO Length = 300 Score = 213 bits (543), Expect = 8e-54, Method: Composition-based stats. Identities = 82/316 (25%), Positives = 140/316 (44%), Gaps = 19/316 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 D + GV+F NP +S G E + GG+ K + R Sbjct: 1 MIDTKVNIAGVEFKNPVIAASGTFGFGREFLEYFPISKLGGLATKGLTLREREGNKGVRI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + IG +N + +EE L L + D V+IA++ G ++ Sbjct: 61 HETIGGIMNSIGLQNPGI--DAFIEEELPFL-----NSQDTVIIANVSGNTIDEYVISVE 113 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + + DMIE N SCP + G G E+ V++ P++ K++P+ + Sbjct: 114 KLNQTDIDMIELNISCPNVKEG--GISFGTKAEIASNVVTQVRKVCQKPLIVKLSPSAEN 171 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+A + GAD ++ +NT ++ ID+++K + + +G SG +KPIALR Sbjct: 172 IVEMAESCVEAGADALSLVNTFPALA-IDISKKKAI----FDNITAGLSGPCIKPIALRM 226 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + ++ D PI GIGGI + DA E+++ GA +QV T ++ G+ Sbjct: 227 VYEVSKAV---DVPIIGIGGIMDYRDAIEYIMAGAWAVQVGTANFIN-PNACAEIIEGIE 282 Query: 302 HYLADQGFDSLQEMVG 317 YL +G +L+E+ G Sbjct: 283 EYLQKEGISTLEEIRG 298 >UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteobacteria RepID=Q1MQG1_LAWIP Length = 314 Score = 213 bits (543), Expect = 8e-54, Method: Composition-based stats. Identities = 83/311 (26%), Positives = 138/311 (44%), Gaps = 21/311 (6%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDTGF 71 + NP +S G E + GG++ K + PR Sbjct: 20 LVLKNPVLTASGTFGYGAEFIGYGDLSQLGGIIVKGLSLKPRKGNPLPRIAETPCGMLNT 79 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL-ARLVQEAGADM 130 IG +N E +++ L L + + +IA++ + +++ EL A L E G Sbjct: 80 IGLQNDGV--ELFIQKKLPRL-----PWKETPVIANLYATSVEEFSELTAILAAEEGVAA 132 Query: 131 IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-KRGSTLPMLAKMTPNIGDMCEVALAA 189 +E N SCP + S G+ GQ P L K AV K + P++ K++PN+ D+ +A A Sbjct: 133 LEVNVSCPNVKSG--GTFFGQDPSLAAKVTEAVCKNAGSKPVMVKLSPNVTDITIIAKAV 190 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 + GAD I+ INT+ + +D+ ++ + + I G SG +KPIALR + ++ Sbjct: 191 ESAGADAISCINTLTGMA-VDIRKRKSLLS----TVIGGLSGPGIKPIALRCVWEV---C 242 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 + + P+ GIGGI + D EF+L+GA +Q+ T I +A L + G Sbjct: 243 KAVNIPVIGIGGITSARDVLEFILVGAHAVQIGTMNFIQ-PDIAFRIAEALPIICNELGI 301 Query: 310 DSLQEMVGLAN 320 + G Sbjct: 302 KNFDSFRGSLQ 312 >UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular organisms RepID=PYRD_NITMU Length = 348 Score = 213 bits (542), Expect = 1e-53, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 112/314 (35%), Gaps = 35/314 (11%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLV 65 S + G+ FPNP L++ N E G+G + T+ PR L Sbjct: 44 SRSIMGLTFPNPVGLAAGLDKNG-EHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLP 102 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQWE 117 + ++ I L N+ A+ K ++ +G+N + Sbjct: 103 QANS-IINRMGFNNNGIEGLVANVKAM-------DYKGILGINIGKNFDTPVEKAVDDYL 154 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGSTLPML 172 R A I N S P + + L+ A + G P+L Sbjct: 155 ICLRKAYRY-ASYITVNISSPNTPNLRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLL 213 Query: 173 AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ ++ +A + DG+ A NT S ++ + G S Sbjct: 214 VKIAPDLELPEIDSIAALLMKHRVDGVIATNTTLSRAGVE--------TLPHAREAGGLS 265 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G + A + ++ + PI G+GGI A E + GA+ +QV +G++ G Sbjct: 266 GAPLAKRATSVVARLHHALQ-GALPIIGVGGIMDAAGATEKIAAGASLIQVYSGLVYRGP 324 Query: 291 RIVEDMASGLSHYL 304 +V ++A L + Sbjct: 325 HLVGEIAQVLCNAN 338 >UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular organisms RepID=PYRD_RHORT Length = 367 Score = 213 bits (542), Expect = 1e-53, Method: Composition-based stats. Identities = 72/334 (21%), Positives = 129/334 (38%), Gaps = 35/334 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L+ + G +F NP L++ N E+ +D G+G V T+ PR Sbjct: 42 PVLACSLWGRRFANPLGLAAGFDKNG-EVADALFDLGFGFVEVGTVTPRPQAGNPRPRLF 100 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------Q 114 L ++ +GF N E A R + + ++ +G+N+ Sbjct: 101 RLTQDRAVINRMGFNNQGM------EAMAARFVRARP----RGVLGINLGKNKTTEDAAG 150 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR---GSTLPM 171 +E + AD + N S P L+ + A+ G P+ Sbjct: 151 DYEAGIAKLAPL-ADYLVINVSSPNTPGLRALQGREPLSLLIARARAALDAACPGLRPPL 209 Query: 172 LAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 L K+ P++ DM ++A A GG DG+ NT + ++ G G Sbjct: 210 LLKVAPDLTDEDMADIAEVALGGGLDGLICTNTTIARPKSLVSDHAG--------ETGGL 261 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG ++ A + I ++ + P+ G+GGI +A + GA+ +Q+ + ++ G Sbjct: 262 SGLPLRYRARQVIARLYGLTK-GALPLIGVGGIGDGAEAYARIRAGASLIQIYSALVYEG 320 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 +V + L+ L GF S+ E VG + + Sbjct: 321 PGLVGRIKRDLAQRLRADGFASVAEAVGADHRDP 354 >UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 Tax=Archaea RepID=A1RZC9_THEPD Length = 299 Score = 213 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 86/320 (26%), Positives = 146/320 (45%), Gaps = 22/320 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 +LS+ G++ NP ++S +G + +A D G G V KT+ +P Sbjct: 1 MVELSVEVAGLRLRNPVVVASGVLGVSVGLMKRAEDAGAGAVTSKTVTLNPREGYPNPVV 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L +G N E + + R +IASI + +A Sbjct: 61 YELDYGLVNSMGLPNPG-------AEEMGRILREARRVLGIPVIASIGASTPDEALRIAE 113 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ G D +E N SCP + G+D+ P+ V A+K + K++P+ GD Sbjct: 114 ALE--GFDALELNASCPHVKGL--GADLMSDPDAVYGIVSALKSSGYR-VFLKLSPH-GD 167 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 VA A G DG AINT K++ ID+ + + +A+ PIA+R Sbjct: 168 YLAVARKAYSAGVDGFTAINTAKAMV-IDVYARKPVLGGVVGGLSG----RAIHPIAVRV 222 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + ++ E + P+ G GG+E W +A E +L GA+ + V T + + G+ ++ ++ G+ Sbjct: 223 VYELHR--EFPEVPVIGTGGVEGWVEAVELILAGASAVGVGTAL-KRGFEVIGEILGGIE 279 Query: 302 HYLADQGFDSLQEMVGLANN 321 YL D+GF S++ +VGLA+ Sbjct: 280 RYLRDEGFPSVESIVGLAHK 299 >UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus sp. RS-1 RepID=PYRD_ROSS1 Length = 361 Score = 213 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 122/329 (37%), Gaps = 37/329 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++ + G+ F NP +++ ++ G+G + T+ PR L Sbjct: 52 LAVDWSGLHFANPVGVAAGFDKR-ADLVDGLALLGFGHIEVGTVTPRPQPGNPRPRLFRL 110 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 ++ +GF + +A L+ V++ +G+N E R Sbjct: 111 PEDTALINRLGFNSPGMVAVARA---------LRARRSRDVIVGVNIGKNRDTPLE--RA 159 Query: 123 VQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPML 172 V++ A D + N S P + L+ + R + P+ Sbjct: 160 VEDYVATFVALAPIADYVAVNISSPNTPGLRRLHERAALETLLHELTRLNRALPHPRPIA 219 Query: 173 AKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K++P+ + V A G A NT + ++ G S Sbjct: 220 LKVSPDETPDQLEAVVRAGCDAGIAAFIATNTTLARDDLHSRL---------AIETGGLS 270 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G+ + A + I + P+ G+GGI T EDA + + GA +Q+ TG++ G Sbjct: 271 GRPLTQRARQVIGAIYRLTHGAP-PVIGVGGIATAEDAYQHIRAGARLIQIYTGMVYAGP 329 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLA 319 I D+ GL+ L GF SL+E VG+ Sbjct: 330 AIARDIKQGLARRLRRDGFTSLEEAVGVM 358 >UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whipplei RepID=Q83GM4_TROWT Length = 335 Score = 213 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 58/311 (18%), Positives = 115/311 (36%), Gaps = 29/311 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L T G+ F P +++ ++ Y G+G V T+ PR + Sbjct: 41 LGTTSMGLYFDTPLGIAAGFDKF-ADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRV 99 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWE 117 + + +GF N ++ + ++++ +I +G+++ + + Sbjct: 100 MSQKALINSMGFNNP------GAQKMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAK 153 Query: 118 ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 + + + +D + N S P VG +++ + + P+L K+ Sbjct: 154 DYVKSFELLADVSDYLVINVSSPNTEGLRTLQSVGNLNKILRS-VKPIADRFKRPVLIKI 212 Query: 176 TPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 +P++ D+ +AL K G G+ A NT T + S G SG Sbjct: 213 SPDLSNSDVTNIALLVKEFGLAGVVASNTTTKRTGLPNE---------FSSLHGGLSGPM 263 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 +K +L ++ +R F I +GG+ + D E L GA +Q T + G Sbjct: 264 LKERSLEMLKILRRDLPKNKFCIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNGPYWA 323 Query: 294 EDMASGLSHYL 304 ++ LS Sbjct: 324 SNINRDLSRLR 334 >UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L830_PLAKH Length = 556 Score = 213 bits (541), Expect = 2e-53, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 125/345 (36%), Gaps = 44/345 (12%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVK 66 G+ F NPF +++ N G+ + TI PR V+ Sbjct: 222 TGIGGLNFINPFGVAAGFDKNGV-CIDGILKLGFSFIEVGTITPKPQKGNDKPRIFRDVE 280 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP--DKVLIASIMGENEQQ---WEELAR 121 + I I + ENL R ++ + + +G+N+ E+L+ Sbjct: 281 TRS-IINCCGFNNIGCDEVTENLKRFREKQKTDKLLHRHFVGVSLGKNKDSADILEDLSY 339 Query: 122 LVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS------------ 167 + G AD I N S P + ++ + V + Sbjct: 340 CISRIGKYADYIAINVSSPNTPGLRDNQQSERLQRIILRVKEEVDKLEESNVVGDDVVRG 399 Query: 168 --------TLP-MLAKMTPNIGDMCE--VALAAKRGGADGIAAINTVKSITNIDLNQKIG 216 P + K+ P++ + + +A + DG+ NT NI Sbjct: 400 DTWVNTSKRKPLVFVKLAPDLEEGEKKKIADVLLKTKVDGMIICNTTTEKFNIK------ 453 Query: 217 MPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGA 276 N + G SG+ +K ++ +FI QM + + PI GGI T +DA E + GA Sbjct: 454 ----NFQDKKGGVSGEKLKDVSTKFISQMYNYT-NKKIPIIASGGIFTGKDALEKIEAGA 508 Query: 277 ATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 + Q+ + ++ G + + L H L +G+ L++ +G A+ Sbjct: 509 SVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYKLEDAIGKAHR 553 >UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria RepID=PYRD_FLAPJ Length = 350 Score = 212 bits (540), Expect = 2e-53, Method: Composition-based stats. Identities = 66/323 (20%), Positives = 120/323 (37%), Gaps = 47/323 (14%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFD 62 K L G+KF NP L++ ++ + + G+G + T+ R Sbjct: 48 KRLEREVFGLKFKNPVGLAAGFDK-DAKLYKELSNFGFGFIEIGTLTPKGQEGNPKKRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 L ++ +GF N L A+ RLK++ + VLI +G+N+ Sbjct: 107 RLQEDSAIINRMGFNNGGV---------LEAVERLKKN--NGVLIGGNIGKNKLTPNENA 155 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKY-----------CR 161 +E + + D N S P + + +L+ Sbjct: 156 TSDYEICFDALYDY-VDYFVVNVSSPNTPNLRELQEKEPLTQLLNTLQNKNQNKQKQTRD 214 Query: 162 AVKRGSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 + P+L K+ P++ + + ++ K GI A NT S + Sbjct: 215 GAQSSGAKPILLKIAPDLTNEQLLDIIDIVKTTKIAGIIATNTTISREGL---------Q 265 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATL 279 + + G SGK + + I+ + + FPI G+GGI +DA E L GA+ + Sbjct: 266 SINRIEMGGLSGKPLTNRSTEVIRFLSQKS-NKAFPIIGVGGIHCVQDAIEKLEAGASLI 324 Query: 280 QVTTGIMQYGYRIVEDMASGLSH 302 Q+ TG + G +V+ + + Sbjct: 325 QLYTGFIYEGPALVKAINKEILK 347 >UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria RepID=B8G4M8_CHLAD Length = 355 Score = 212 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 64/346 (18%), Positives = 131/346 (37%), Gaps = 20/346 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS T+ G+K P ++SP+ E+ + + G G VV ++ + S D Sbjct: 1 MIDLSTTYLGMKLRTPIVAAASPISRNVELVRQLEEAGLGAVVMYSLFEEQIIQQSLELD 60 Query: 63 HL----VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + + + E L + LK+ +I S+ G ++ W Sbjct: 61 RMLSHGAESFAEALSYLPEHGAYSTGPERYLEQVAALKQGLS-IPVIGSLNGVSKGGWVH 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 ARL+QEAGAD +E N + ++ S++ ++ +AV+ ++P+ K+ P Sbjct: 120 YARLIQEAGADALELNIYFVPIDTNITSSELE---DIYVDLVKAVRAEISIPLAVKIGPY 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + A GA+ + N + DL Q P + S A ++ Sbjct: 177 FTALPNFAWRLMEAGANALVLFNRFYQ-PDFDLEQLSVRPNLQ-------LSTSAELRLS 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ-YGYRIVEDMA 297 LR+I + L G+ D + L+ GA + + ++ ++ + Sbjct: 229 LRWIALLYGRIPLEFAL---SSGVHNAIDVLKGLMAGANVTMIASAFLRGRATDVLRTIL 285 Query: 298 SGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDK 343 + +L + ++S+ ++ G + V ++ + Sbjct: 286 HDMELWLTEHEYESIAQLHGSMSQRAVAEPAAFERANYIRVLDDYR 331 >UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromonas sp. RCC299 RepID=C1EIH8_9CHLO Length = 488 Score = 212 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 71/365 (19%), Positives = 123/365 (33%), Gaps = 55/365 (15%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 L++ G++F NP L++ + G+G V ++ PR Sbjct: 129 PPALAVDAWGLRFANPIGLAAGFDK-DAKAFPALGAMGFGFVEIGSVTPKPQPGNPKPRV 187 Query: 62 DHLVKEDT--GFIGFKNMEQIAEHP-LEENLAALRRLKEDYPDKVL-------------- 104 L + GF + LE A R + ++ + Sbjct: 188 FRLRELGAVINRYGFNSEGHEPARARLEAYRADTRATQSEFDATPVTPVTPEGAGVPRRL 247 Query: 105 ------IASIMGENE-----QQWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQ 151 + +G+N+ ++ A V+ G AD I N S P Sbjct: 248 AERGAPVGVNLGKNKLTPEAAAADDYALGVRALGHTADYIVVNISSPNTPGLRALQGKAH 307 Query: 152 SPELVEKYCRAVKR-------------GSTLPMLAKMTPNIGD--MCEVALAAKRGGADG 196 L+ K A P+L K+ P++ D + +V AA DG Sbjct: 308 LKGLLRKVLAARDESALKSRTGGGQTHAHKPPVLLKIAPDLTDGDIKDVVAAATSCAVDG 367 Query: 197 IAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPI 256 I NT + G G SGK + + + ++ P+ Sbjct: 368 IIVSNTTIARPEDVAAHARG-------GEAGGLSGKPLMDPSTEVLFRVYQLTG-GKIPL 419 Query: 257 SGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMV 316 G GG+ + DA E + GA+ +Q+ T G +V M + L+ L + G++S+ E + Sbjct: 420 VGCGGVASGRDAYEKIRAGASLVQMYTAFAYAGPALVPAMKAELAACLREDGYESVAEAI 479 Query: 317 GLANN 321 G A+ Sbjct: 480 GAAHR 484 >UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteobacteria RepID=PYRD_DICNV Length = 337 Score = 212 bits (539), Expect = 3e-53, Method: Composition-based stats. Identities = 62/307 (20%), Positives = 111/307 (36%), Gaps = 34/307 (11%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVK 66 I G FPN L++ N + G+G + T PR L + Sbjct: 43 IHLLGHTFPNRLGLAAGLDKNAV-AISAFDRLGFGFIEVGTATPRPQSGNPKPRLFRLPE 101 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQWEE 118 I L + +AA+++ LI +G+N+ + Sbjct: 102 HQA-IINCMGFNNDGVVALCQQVAAVKKRTRA-----LIGINIGKNKLTPNERAADDYL- 154 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLPMLA 173 +A AD + N S P EL+++ + S T+P+L Sbjct: 155 IAMSTAYPYADYLAINISSPNTVGLRDLQHGAALCELLQRLKTERDKLSAVYEKTVPLLV 214 Query: 174 KMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P+ + E+ + G DGI A NT T + ++ G SG Sbjct: 215 KIAPDNEREQLDEMLSIIEDSGIDGIIATNTTLDKTAVTGHRYAD--------EQGGLSG 266 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 K + + + I +R D P+ GG+ + +D L GA +Q+ +G++ +G + Sbjct: 267 KPLTEKSTKIIAHIRERL--PDLPLIASGGVMSADDYYAKLEAGADLVQIYSGLIYHGPQ 324 Query: 292 IVEDMAS 298 +++D Sbjct: 325 LIKDCLR 331 >UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria RepID=PYRD_DEIRA Length = 369 Score = 211 bits (538), Expect = 3e-53, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 115/333 (34%), Gaps = 38/333 (11%) Query: 6 LSITFCGVK-----FPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 L T G F +P L++ N + G+G V T+ P Sbjct: 54 LRRTLWGQTPSEQTFESPLGLAAGLDKN-AQAVPAFTAFGFGFVEVGTVTPLAQSGNERP 112 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----Q 114 R L +++ I + LA L + +I G+N+ Sbjct: 113 RLFRLPEDEA-LINRMGFNNGGTAAMHARLAVLTDRAA-----PVWVNI-GKNKVTPNED 165 Query: 115 QWEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----KRGS 167 E+ + V+ G AD N S P LV V + Sbjct: 166 AAEDYRKCVRALGDLADAFVVNVSSPNTPGLRALQAADDLAALVRAVLDEVEAGRVRTLR 225 Query: 168 TLPMLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 P+L K+ P++ D A GA G+ NT S + + Sbjct: 226 RPPVLVKLAPDLHPADFEASVGAVLDAGASGLIISNTTLSRGGL---------SHPNREQ 276 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SG+ + + ++ + PI G+GG+ + EDA LL GA ++V + + Sbjct: 277 AGGLSGRPLTDRSTELVRDAYRLTRGQ-VPIVGVGGVFSAEDAYAKLLAGADLVEVYSAL 335 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 + G +V ++ +GL L G ++ ++VG Sbjct: 336 IYRGPGLVREINAGLVKLLERDGVRNIADVVGQ 368 >UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=PYRD_METI4 Length = 348 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 61/318 (19%), Positives = 112/318 (35%), Gaps = 33/318 (10%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L G++FPNP L++ N G+G V T+ +PR L Sbjct: 49 LPKELWGMQFPNPVGLAAGFDKNGV-GLRAWESFGFGFVEIGTVTPLPQEGNPAPRLCRL 107 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQW 116 KE N + L+++ K+ + +G+N + + Sbjct: 108 PKEGA----LWNSLGFPSQGAQRVAERLKKVFLSGRPKIPVGINIGKNRHTPLEETIEDY 163 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 ++ ++ G D N S P + EL+ + P+L K+ Sbjct: 164 KKCFSYFKDLG-DFFVVNVSSPNTPGLKSLQQK-RFLELLFDRLNPLNSSPRKPLLVKIA 221 Query: 177 PNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P+I ++ + R + GI NT+ P G SGK + Sbjct: 222 PDIELKNLAGILEVLLRNESVGIVIANTL--------------PAKGPGGKEGGLSGKPL 267 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + ++L I+ ++ PI G+GGI + +DA E + GA +++ TG + G Sbjct: 268 RELSLGLIRFVKKET-AGRLPIIGVGGIFSSKDAFEKMEAGADLIEIFTGFVYNGPSFPA 326 Query: 295 DMASGLSHYLADQGFDSL 312 ++ L ++ Sbjct: 327 NLCRELERLRKTPQCSAI 344 >UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10 Tax=Saccharomycetales RepID=PYRD2_KLUMA Length = 446 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 58/329 (17%), Positives = 113/329 (34%), Gaps = 39/329 (11%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L + G NP ++ + E + G+G V ++ PRF L Sbjct: 107 LHVNVFGKTLTNPVGCAAGLDKDG-EAIDGIFAGGFGYVEIGSVTPLPQPGNPKPRFFRL 165 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLA-ALRRLKEDY-------------PDKVLIASIMG 110 ++ I + +NL + R Y L+ +G Sbjct: 166 PMDEA-VINRYGFNSSGHDSVVKNLQNRVSRFINSYFCNDINAVDNLSLYQNKLLGINLG 224 Query: 111 ENE--QQWEELARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG 166 +N+ + ++ + V++ AD++ N S P L+ + Sbjct: 225 KNKNGDEVQDYLKGVEKFQKYADVLVINVSSPNTPGLRGLQKESILTNLLSQVVAKRDSL 284 Query: 167 ST-----------LPMLAKMTPNIGDMCEVALAAKR--GGADGIAAINTVKSITNIDLNQ 213 + P+L K+ P++ + A+A DGI NT + + Sbjct: 285 VSSGNVLGAKTHRPPVLVKVAPDLEEEEIKAIAEAAKKSKVDGIIVSNTTIQRPASLITE 344 Query: 214 KIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLL 273 + G SGK +KP++L+ ++ M + + + G GGI + DA EF Sbjct: 345 DKNLVA-----QAGGLSGKPLKPLSLKALKTMAHYTKGSGLVLVGCGGISSGADAIEFAK 399 Query: 274 LGAATLQVTTGIMQYGYRIVEDMASGLSH 302 GA +++ T G ++ + ++ Sbjct: 400 AGATMVELYTCYAYRGPGLIARVKDEITE 428 >UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UF20_9PROT Length = 378 Score = 211 bits (537), Expect = 4e-53, Method: Composition-based stats. Identities = 61/332 (18%), Positives = 115/332 (34%), Gaps = 27/332 (8%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPR 60 DL++ G++F NP L++ N A G+ V TI PR Sbjct: 39 SKADLTVRIAGLEFANPLGLAAGFDKN-ATCFNGAMGLGFAHVEVGTITPKRQPGNPKPR 97 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-QQWEEL 119 L +E+ I + +NL A + + A+ + + + Sbjct: 98 VFRLPEENA-VINRYGFNSHGMDRVAKNLYATASKRVGILGVNVGANKTSNDPIDDYRQA 156 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-----------ST 168 ++ AD I N S P +L+ + Sbjct: 157 VAMLAPY-ADYITLNISSPNTPGLRNLQTKRHLADLLMAGFAGCREAGFEPACRSTGLRQ 215 Query: 169 LPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 P+ K+ P++ D+ + + GA GI A NT + G+ V+ + Sbjct: 216 KPIFLKIAPDLRHDDLATIVDSCVETGASGIIATNTTIARP-------TGLSGVH-AGEV 267 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 G SG + + + ++ + + G+GG+ + A +L+GA +Q+ TG+ Sbjct: 268 GGLSGGPLFAASTGILAEVARLSQN-RLALIGVGGVSSGWQAYAKILVGADMVQLYTGLA 326 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 G + + L+ L G ++ E+ G Sbjct: 327 LEGPHLPNRILHELAQMLDADGATTIDEVKGQ 358 >UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G037_9DELT Length = 334 Score = 211 bits (536), Expect = 5e-53, Method: Composition-based stats. Identities = 85/336 (25%), Positives = 142/336 (42%), Gaps = 21/336 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 + +L+ F +K +P +S + GG+ K I PR Sbjct: 15 SVELACDFGPLKLRSPILTASGCFAYGQQFAEFMDLRQIGGLSTKGISPLPRHGNPLPRI 74 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG +N+ E L E L L L D + + G + + + + A+ Sbjct: 75 YETASGMINSIGLENVG--CEAFLTEKLPFLADL-----DVSVWVNFFGTDFETYVDCAK 127 Query: 122 LVQEAG---ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 + E G D++E N SCP + G + G PE+ + +A S +P++ K+TPN Sbjct: 128 TLSEGGEGRIDVLEMNISCPNIKKG--GIEFGTVPEVAHRLTKACVEASEVPIVVKLTPN 185 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ +A A K GA G++ INT+ ++ ID+ + ++ G SG A+KP+A Sbjct: 186 VSDIVAMAQAVKEAGAIGVSLINTITAMA-IDVRSRRSRI----ATTYGGLSGPAIKPVA 240 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR + Q+ FPI G+GGI T ED E+ + GA +Q+ T + Sbjct: 241 LRMVHQVAKALPG--FPICGMGGILTGEDVLEYFIAGAHCVQLGTINFSE-PGAALRVTR 297 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYI 334 L +A+ G + +Q+ V + S Sbjct: 298 ELRELMAELGIERVQDAVATLGGYEAEPAHAEVSPW 333 >UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVX7_9BACT Length = 356 Score = 210 bits (535), Expect = 7e-53, Method: Composition-based stats. Identities = 59/314 (18%), Positives = 119/314 (37%), Gaps = 32/314 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 L G++FPNP L++ N E + G+G V T+ PR Sbjct: 47 HPSLEREVFGLRFPNPIGLAAGFDRNG-EAFRELSALGFGFVEIGTVTPQPQAGNPRPRI 105 Query: 62 DHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN------- 112 L + G N A+ +L+ + D+++I +G+N Sbjct: 106 FRLPADRAIINRSGLNNKGLY---------KAIAQLRHRH-DRLIIGGNIGKNTLTQPSQ 155 Query: 113 -EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-RGSTLP 170 + ++ R + + D N C ++ + +++ + + P Sbjct: 156 VAADYLKMFRNLYQY-VDYFSINVCCDNCADGSVSHNKAHLMNILQPLFDFRRGQNQYRP 214 Query: 171 MLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K++P++ D + EV DGI A+N S ++ +++ + Sbjct: 215 ILLKISPDLPDPLIDEVTDLMLSTPLDGIVAVNGTFSRKGLETDEETLD-----EIGSGR 269 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG + A+ ++++ +PI G+GG+ D L GA+ +Q+ TG + Sbjct: 270 LSGAPLTQRAIEVVRRIHRRSH-GAYPIIGVGGLMNARDVKAMLAAGASLVQLYTGYIYE 328 Query: 289 GYRIVEDMASGLSH 302 G +V+++ L Sbjct: 329 GPSLVKEICRALID 342 >UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+] (DPD) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase) (PydA) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VG14_9BACT Length = 821 Score = 210 bits (535), Expect = 8e-53, Method: Composition-based stats. Identities = 111/413 (26%), Positives = 181/413 (43%), Gaps = 34/413 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRF 61 L F G K +PF LS++P + YE KAY GW G + KT + Sbjct: 427 PVSLETDFFGRKMDSPFILSAAPPSDGYEQMKKAYLAGWSGGIMKTAFDNEDIHIPGEYM 486 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG-------ENEQ 114 + F N + ++EHPL+ + + L +++PD++ +AS G +++ Sbjct: 487 FTFGDKKK---TFANCDNVSEHPLDRVCSEIALLIKEFPDRLTMASTGGPVTGDDINDKK 543 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPML 172 W+ +++AGA IE + SCPQ G V Q P L K V S +P L Sbjct: 544 GWQANTIKLEKAGAMGIEYSLSCPQGGDGTKGDIVAQDPALTAKIIDWVMEISNPEIPKL 603 Query: 173 AKMTPNIGDMCEVALAAKR------GGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSI 226 K+T + + + A K G GI NT ++ + + I+ Sbjct: 604 FKLTGAVTSIYPILSAVKSVLDKYPGKKAGITLANTFPALAFREKEKPWDEGIIV----- 658 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 G SG+++ PI+ + + ISG GG + DAA FL LGA +Q T + Sbjct: 659 -GLSGESILPISYLNLARA----GNSGIFISGNGGAMNYLDAANFLALGAGNVQFCTIVE 713 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVG 346 +YGY I++++ GLS+ L +G S+ E++G+A + + + + C+ Sbjct: 714 KYGYGIIDELKMGLSYLLEAKGLKSVAELIGIAQPKPITDFLDLPTKTKSSSLIKELCLK 773 Query: 347 CGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 CG C C + ++ P + +KCVGC LC +C G +E+ K Sbjct: 774 CGNCTR-CPYQAIEL----DEDCYPKIDPDKCVGCSLCTQLCFAGALEMKNEK 821 >UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZTF1_OPITP Length = 332 Score = 209 bits (533), Expect = 1e-52, Method: Composition-based stats. Identities = 59/343 (17%), Positives = 130/343 (37%), Gaps = 19/343 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI----ANEV 57 + +L+ T+ G+ NP + +SP + E + + G +V +++ + Sbjct: 1 MQLNLATTYLGLPLRNPLIVGASPFSDDLEAARQLQEAGAAALVMRSLFEEQIDLEQRAL 60 Query: 58 SPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 + + L + F + + L + L + D +IAS+ G + W Sbjct: 61 NRDLEALTESFAEASSFFPEYGEYQLTPDRYLRQIELLTSEL-DIPIIASLNGRHPGGWL 119 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + AR + AGAD IE NF G ++ + + + R+V +P+ K++P Sbjct: 120 DYARKFEAAGADAIELNFYQLVTDPKVSGDEIE---DELIETLRSVVTAVRIPVAVKLSP 176 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + A ++ GA G+ N + + D++ P + S + Sbjct: 177 FHTSLPHFTQALRQAGAAGLVLFNRLYQ-PDFDVDALEVQPTLR-------LSDPGELLL 228 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 LR++ + ++ GG+ + D A+ +L GA +Q+ + +++ G +++ + Sbjct: 229 RLRWLAILS---PNHLGSLAASGGVHSGTDVAKAVLAGADAVQIVSAVLRQGPAVLKTLL 285 Query: 298 SGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 ++ + + E G N P + Sbjct: 286 QDFETWMRTHEYTHVGEFRGGLNLRHCPDPAALERANYQRILQ 328 >UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine dehydrogenase n=1 Tax=Acyrthosiphon pisum RepID=UPI0001791DE1 Length = 1286 Score = 209 bits (531), Expect = 2e-52, Method: Composition-based stats. Identities = 115/369 (31%), Positives = 164/369 (44%), Gaps = 54/369 (14%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF--FIANEVSPRF 61 DLS+ CG++F NPF L+S+P M +A+ GW V KT G + VSPR Sbjct: 683 VDLSVRMCGLRFMNPFGLASAPPTTSAAMIRRAFQAGWAFAVTKTFGLDKDLVTNVSPRI 742 Query: 62 DHLV---------------------KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP 100 L D F N+E I+E L ++R LK D+P Sbjct: 743 VGLGGHGVGVGSAASGIGPGTLGAGDSDVARNAFLNIELISEKTAAYWLRSIRELKRDFP 802 Query: 101 DKVLIASIMGENEQ-QWEELARLVQEAGADMIECNFSCPQMTSH-AMGSDVGQSPELVEK 158 +LIASIM + W LARL +AGAD +E N SCP MG GQ P LVE Sbjct: 803 QHILIASIMCAYIENDWTSLARLACDAGADALELNLSCPHGMGESGMGLACGQDPVLVEN 862 Query: 159 YCRAVKR-----------GSTLPMLAKMTPNIGDMCEVALAAKRG-GADGIAAINTVKSI 206 R VKR + +P+ K+TPN+ D+ VA AA R GADG+ A+NTV ++ Sbjct: 863 ISRWVKRVAVRPASDGGTPTAVPVFVKITPNVTDVVAVARAAVRLGGADGVTAVNTVSAL 922 Query: 207 TNIDLNQKIGMPIVN--------GKSSISGYSGKAVKPIALRFIQQMRTHP--------- 249 +D+ G P +++ G SG AV+P+ LR + + Sbjct: 923 GPLDVTGNGGRPWPGVGRTTAETPRTTYGGMSGTAVRPMGLRAVSALSRALGPDATAGGD 982 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 I GG+++ ++L GA +QV + + + IV+D +GL L G Sbjct: 983 GGPPVQIMATGGVDSAAATLQYLYCGAKVVQVCSAVQNQDFTIVQDYITGLKALLYMTGR 1042 Query: 310 DSLQEMVGL 318 ++ V Sbjct: 1043 GGEEQQVEQ 1051 Score = 85.9 bits (211), Expect = 2e-15, Method: Composition-based stats. Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 6/130 (4%) Query: 274 LGAATLQVTTGIMQYG----YRIVEDMASGLSHYLADQGFDS-LQEMVGLANNNIVPAED 328 A + G G I G + L + ++ VG A + + Sbjct: 1103 AAADMVDAIQGKKSNGVDRKPVITVSAPKGTNDGLVPATVSTPVELAVGRALKAVGAYKS 1162 Query: 329 LDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVC 388 LDR V +N D C+ CG+CY++C D G+QA+ K+ H + C GC LC VC Sbjct: 1163 LDRRAQVVALVNEDSCINCGKCYMACNDSGYQAITMDPKSHAVHVQPDSCTGCTLCLTVC 1222 Query: 389 PV-GCIELGE 397 P+ GCI + E Sbjct: 1223 PIPGCISMVE 1232 Score = 44.7 bits (104), Expect = 0.006, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 23/77 (29%), Gaps = 2/77 (2%) Query: 315 MVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCGRCYISCYDGGHQAMEWSEKTRTPHCN 374 +A N+ + D C GC C C G + EKT N Sbjct: 1183 KCYMACNDSGYQAITMDPKSHAVHVQPDSCTGCTLCLTVCPIPG--CISMVEKTVPHVVN 1240 Query: 375 TEKCVGCLLCGHVCPVG 391 + L+ + CP Sbjct: 1241 RGLGLRQLVSTYACPND 1257 >UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacteria RepID=Q47C62_DECAR Length = 336 Score = 208 bits (530), Expect = 3e-52, Method: Composition-based stats. Identities = 70/328 (21%), Positives = 132/328 (40%), Gaps = 18/328 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA---NEVSP 59 DLS T+ G+ NP SS+P+ + + D G +V ++ ++ Sbjct: 1 MPDLSTTYLGLSLKNPLVPSSTPLSHDLDAVLHLEDAGAAAIVMHSLFEEDVRHDEQMID 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 RF G + L+ L ++RLK ++AS+ G + W EL Sbjct: 61 RFLVHPDTFGEATGHLPFGHDYQSRLDSYLEQIQRLKSRLA-IPVVASLNGSSLSGWVEL 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + +Q AGAD +E N + + + +K ++P+ K++P Sbjct: 120 GKEMQGAGADALELNAWYMPSDPKISCEAIE---DHHVSLLQELKTVVSIPVSMKLSPFF 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 + + GA GI+ N +IDL + V S A +A+ Sbjct: 177 SSLPHFVHQIEMAGAAGISLFNRFFQ-PDIDLETLSVVDRVQ-------LSSSADTLLAM 228 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R+I +R ++ GG+ T EDA + LL GA + + +++ G + + ++ + Sbjct: 229 RWIAILR---GSTKLSLAATGGVHTAEDALKMLLAGADVAHMASALLKRGPQALGEVLAA 285 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAE 327 ++H+L + + S+ +M G + P Sbjct: 286 MTHWLDEHEYSSVAQMKGSMSQQNSPNP 313 >UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira RepID=Q056I9_LEPBL Length = 384 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 62/335 (18%), Positives = 117/335 (34%), Gaps = 30/335 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDH 63 L G++F NP + + E+ G+G + TI + PR Sbjct: 68 RLKTRVAGIEFENPLGMGAGFDKTG-ELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFR 126 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQ 115 + D I E +A ++ K G+ + + Sbjct: 127 YPE-DQALINHMGFNNPGADSAERIIAPQKKRKIR-------GINAGKTKIISEEKAVED 178 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 + + + AD N S P L++ + + +P+ K Sbjct: 179 YIYTLKKLSPY-ADYAVINISSPNTPGLRDFQKQKNFVSLIQGIKNGLGKNFIIPLFVKF 237 Query: 176 TPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D+ + ++ DG+ NT ID + P V + G SG Sbjct: 238 APDMETKDLEALLESSLSLKIDGVVLTNTT-----IDKSSLKAYPNVEKE---GGLSGVP 289 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 +K + F++ + R PI G+GGI++ + A E +L GA +Q+ TG + G + Sbjct: 290 LKNRSTEFVRVAYRILK-RRIPIIGVGGIDSEKAALEKILAGADLIQIYTGYIYQGPFLP 348 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNNIVPAED 328 + L +L +Q ++ ++VG + Sbjct: 349 LKILEFLDRFLKEQDLKTVSDLVGKEKEIQYDPKC 383 >UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira RepID=PYRD_BRAHW Length = 303 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 81/320 (25%), Positives = 147/320 (45%), Gaps = 20/320 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L+I F G + N SS G E G V K I + Sbjct: 1 MSRLNINFLGKELKNNVITSSGCFGFGEEYSNYFDVNELGAVNLKGITLNKKDGNK--GT 58 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + + +G I +E ++N+ +K +I +I G ++ ++A + Sbjct: 59 RIAETPSGMINCIGLENPGIEYFKDNI-----IKNIKYSTPIILNINGATIDEYVKVAEI 113 Query: 123 VQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPMLAKMTPNIG 180 E D +E N SCP + + M G S E E +AVK+ S P++ K++PN+ Sbjct: 114 ANEIERVDFVELNISCPNVKNGGM--AFGASCESAESTTKAVKKVLSKKPLIVKLSPNVT 171 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D+ +A A + GAD ++ +NT S+ ++ K P++ + G SG ++PIA+R Sbjct: 172 DIASIAKAVEDAGADSVSLVNTFLSM---KIDTKTRKPLLG--NIFGGLSGACIRPIAVR 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + Q+ + PI G+GGI + DA EF+L GA+ + + GI + ++ +G+ Sbjct: 227 MVYQVYKAVK---IPIVGMGGITNYNDALEFILAGASLVSIGAGIFSNPI-LPIEVINGI 282 Query: 301 SHYLADQGFDSLQEMVGLAN 320 +YL + ++++++G A+ Sbjct: 283 DNYLKENNISNIKDIIGAAH 302 >UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaproteobacteria RepID=PYRD_SHEWM Length = 340 Score = 208 bits (529), Expect = 4e-52, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 121/312 (38%), Gaps = 39/312 (12%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL-- 64 + F GV FPNP L++ + E + G+G + T+ PR L Sbjct: 47 VEFMGVTFPNPVGLAAGMDKDG-ECIDGFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKP 105 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR--- 121 K +GF N ++ +A L+ K LI +G+N+ E + Sbjct: 106 AKGIINRMGFNN------KGVDNLIANLKAAKSGA----LIGVNIGKNKDTPVEQGKDDY 155 Query: 122 -----LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKRGSTLPM 171 V E A I N S P +L+ A K G +P+ Sbjct: 156 LICMDKVYEY-AAYIAVNISSPNTPGLRSLQYGDLLDDLLGSLKAKQKDLAQKHGKYVPI 214 Query: 172 LAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ D + ++A + + DG A NT S + + + G Sbjct: 215 ALKIAPDLSDEEIQKIADSLIKNQFDGAIATNTTLSRDGV--------SGLMNANETGGL 266 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + ++ I+++ + PI G+GGI + DA + L GA+ +Q+ +G + G Sbjct: 267 SGKPLNLLSTSVIKKLSSCL-NGQIPIIGVGGINSAADAIDKLDAGASMVQIYSGFIYQG 325 Query: 290 YRIVEDMASGLS 301 ++++D+ Sbjct: 326 PKLIKDIIEACR 337 >UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphylococcus RepID=Q2YWG7_STAAB Length = 354 Score = 208 bits (528), Expect = 5e-52, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 129/324 (39%), Gaps = 33/324 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 LS T G + NP L++ +C E+ G+G + I PR Sbjct: 47 PTLSQTIQGNTYDNPIGLAAGFDKSC-EVPKALEHLGFGALELGGITPKPQPGNPQPRMF 105 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 L+++D +GF N+ AL L+++ + ++ G N+ + Sbjct: 106 RLLEDDALINRMGFNNIGMN---------KALSHLRKNAYQVPVGINV-GVNKMTPYEAR 155 Query: 116 WEELARLVQEAGAD--MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPML 172 +++ +++ D N S P + D + L + K+ T+P+ Sbjct: 156 YQDYIKVIDTFKHDVSFFTVNISSPNTENLQNFHDKDEFSMLCQALTTFKKQHDVTVPIY 215 Query: 173 AKMTPNIG-DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+T ++ D + L A DGI NT + + K G SG Sbjct: 216 LKLTSDMDFDGLKALLPAITETFDGIILANTTRQRDGL---------TSANKVEEGGLSG 266 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + + L+ I+ +F I G GG+ + EDA + + GA+ +Q+ + ++ G Sbjct: 267 RPLFERNLKLIKYAYQQT-NGEFLIIGTGGVFSTEDAIKMMRHGASLIQIYSSLVIEGPG 325 Query: 292 IVEDMASGLSHYLADQGFDSLQEM 315 + + M G++ YL D FD++ ++ Sbjct: 326 LTKKMNKGIARYLKDHHFDNVSDI 349 >UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Leuconostoc citreum KM20 RepID=B1MZ73_LEUCK Length = 306 Score = 207 bits (527), Expect = 6e-52, Method: Composition-based stats. Identities = 82/319 (25%), Positives = 141/319 (44%), Gaps = 19/319 (5%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSP 59 M+++ L++ G+ NP SS V E G +V KT+ P Sbjct: 1 MMSERLAVKLPGLDLKNPIMNSSGAVFFGLED-KGYAIEETGALVTKTVTMSARAGNPQP 59 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + +G N E + + L A+ + ++AS+ GE ++ L Sbjct: 60 WIINTPSGILNSVGLANPGI--EAVVADILPAIHEKYKTL---PVLASVAGETVGEYVAL 114 Query: 120 ARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 + IE N SCP + M G + E + A++ +TLP+ AKM+PN Sbjct: 115 TERLTATKQVTAIEANLSCPNVDRGGM--AFGVTAESAAEVIHAMRAATTLPIYAKMSPN 172 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + D+ + A + GADGI INTV ++ +DLN + G SG +V PIA Sbjct: 173 VTDIKPIVKAVETAGADGIVLINTVVGMS-LDLNTRQAR----LARGTGGMSGTSVHPIA 227 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +RF+ + P+ G+GG+ T +D E ++ GA+ +Q+ T + ++++ D+ Sbjct: 228 VRFVYETAQ---TVSIPVIGVGGVSTVDDVLELMMAGASAVQIGTALAGN-HQVMADIIR 283 Query: 299 GLSHYLADQGFDSLQEMVG 317 L L GF +++E+ Sbjct: 284 ELPSALDKYGFSNVEEVTK 302 >UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular organisms RepID=C9YAQ9_9BURK Length = 389 Score = 207 bits (526), Expect = 7e-52, Method: Composition-based stats. Identities = 69/311 (22%), Positives = 118/311 (37%), Gaps = 30/311 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFD 62 D +T G++FPN +++ N G+G V T+ PR Sbjct: 76 VDDPVTIAGLQFPNRVGMAAGLDKN-ARCIDGLGAMGFGFVEVGTVTPLAQPGNPKPRMF 134 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRR--LKEDYPDKVLIASIMGENE----- 113 L + + +GF N H L+ +A ++R L++ +L+ +G+N Sbjct: 135 RLPEANALINRLGFNN------HGLDAFIANVQRSALRQSKNPSLLLGLNIGKNAATPIE 188 Query: 114 ---QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-----AVKR 165 + V AD I N S P + L+ A K Sbjct: 189 KATDDYLICLDGVYPH-ADYITVNISSPNTKNLRSLQSDDALDALLGAIAERREQLAQKH 247 Query: 166 GSTLPMLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLN-QKIGMPIVNG 222 G P+ K+ P++ + +A KR G D +N + + + + + Sbjct: 248 GQRKPVFLKIAPDLEADQVAVIAATLKRYGTDSSGKVNNAWGVIGTNTTLSRGAVKGMPH 307 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 + G SG V + I Q+R +DFPI G+GGI + DA + GA +Q+ Sbjct: 308 AEEMGGLSGAPVLEKSNAVIGQLRAALG-KDFPIIGVGGIMSAADAVSKIKAGADAVQIY 366 Query: 283 TGIMQYGYRIV 293 TG++ G ++V Sbjct: 367 TGLIYSGPQLV 377 >UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5E1_CHRVI Length = 338 Score = 206 bits (525), Expect = 8e-52, Method: Composition-based stats. Identities = 74/342 (21%), Positives = 136/342 (39%), Gaps = 19/342 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L T+ G+ NP S+SP+ + D+G +V ++ + Sbjct: 1 MNLKTTYLGLTLKNPLVPSASPLSRSLSAAREMEDSGAAAIVMYSLFEEAITAEAESMTR 60 Query: 64 LVKED-----TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + GF Q E+ LE L +RRLKE D +IAS+ G W + Sbjct: 61 FLHHQDTGFAESSAGFLPDHQDFENGLERYLEQIRRLKESL-DIPVIASLNGVTTGGWVK 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A +Q+AGAD +E N G+ V Q ++ +P+ K++P+ Sbjct: 120 HALELQQAGADALELNVYYIAGDISQNGAQVEQ---RYLDLLTELRGRIRIPINMKLSPS 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + GA+G++ N +I+++ ++ S A +A Sbjct: 177 FSSIGHFVGRLAAAGANGVSLFNRFYQ-PDINIDSLRLQARLHP-------STSAEALLA 228 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 +R+I + + GGI T EDA + LL GA + + + ++Q G + Sbjct: 229 MRWIALLYGRVPG--LSLGATGGIHTSEDAIKLLLAGADVVHLCSVLLQKGPVYTGLILR 286 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 G++ ++ +QGF+S+++ G + VP ++ Sbjct: 287 GIADWMEEQGFESVEDFRGRVSALTVPNPAELERANYINVLD 328 >UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobacterales RepID=PYRD_HELPG Length = 351 Score = 206 bits (525), Expect = 9e-52, Method: Composition-based stats. Identities = 69/325 (21%), Positives = 121/325 (37%), Gaps = 42/325 (12%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L G+ FPNP L++ N M G+G + T+ PR Sbjct: 48 PKLENEILGLNFPNPLGLAAGFDKN-ASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 ++E++ +GF N + R P K I +G+N+ E A Sbjct: 107 RHIEEESLQNAMGFNNYGAVLGA---------RSFNRFAPYKTPIGINLGKNKH--IEQA 155 Query: 121 RLVQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 +++ A D N S P + Q+ V + K + P+ Sbjct: 156 HALEDYKAVLNQCLNIGDYYTFNLSSPNTPNLRD----LQNKAFVNELFCMAKEMTHKPL 211 Query: 172 LAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ DM E+ +A GA GI A NT +V + G Sbjct: 212 FLKIAPDLEIDDMLEIVNSAIEAGAHGIIATNTTID-----------KSLVFAPKEMGGL 260 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SGK + + +++ + + +GGI ++A E + +GA+ LQ+ + + G Sbjct: 261 SGKCLTKKSREVFKELAKAFFNKSV-LVSVGGISDAKEAYERIKMGASLLQIYSAFIYNG 319 Query: 290 YRIVEDMASGLSHYLADQGFDSLQE 314 + +++ L L GF S++E Sbjct: 320 PNLCQNILKDLVKLLQKDGFLSVKE 344 >UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma gondii RepID=B6KTR1_TOXGO Length = 592 Score = 206 bits (525), Expect = 9e-52, Method: Composition-based stats. Identities = 60/373 (16%), Positives = 128/373 (34%), Gaps = 55/373 (14%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L++ G+KF +P L++ + E A G+ + +I PR L Sbjct: 231 LNVDINGLKFLSPIGLAAGFDKH-AEAPAALLRMGFSFLEVGSITPKPQPGNPKPRLFRL 289 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAAL--RRLKEDYPDKVLIASIMGENE---QQWEEL 119 ++ + I + L A RL++ + + ++ +G+N+ +L Sbjct: 290 YEDRS-VINRFGFNSNGADYAQTQLEAFSEARLRDPFTAQGVLGVSLGKNKTSEDAVADL 348 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG----------- 166 V++ G AD + N S P +++ + Sbjct: 349 REGVKKLGRFADFLVVNLSSPNTPGLRSLQSASHLAAIIDGVQEELDALDRQAQAASQKQ 408 Query: 167 ----------------------STLPM-LAKMTPNIG--DMCEVALAAKRGGADGIAAIN 201 P+ K+ P++ + +A A DG N Sbjct: 409 RNERRRHGGNPEETKAFYANQTGRRPLFFVKIAPDLSMEEKESIAKVALEKNLDGFVVSN 468 Query: 202 TVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGG 261 T + KS G SG+A+K ++ + M + I GG Sbjct: 469 TTIQRPETLKS--------PAKSETGGLSGRALKHLSTACVSDMYKLTQ-GKLAIIATGG 519 Query: 262 IETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 +E+ DA + + GA+ +++ + ++ G ++ + + L H L ++G+ + VG + Sbjct: 520 VESGRDALDKIEAGASLVELYSSMVYIGPQVARRVKNELYHALNEKGYKDVAAAVGRKHK 579 Query: 322 NIVPAEDLDRSYI 334 ++ + + Sbjct: 580 HVPEKKLQAPKFD 592 >UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMB2_9BACT Length = 304 Score = 206 bits (524), Expect = 1e-51, Method: Composition-based stats. Identities = 78/322 (24%), Positives = 135/322 (41%), Gaps = 21/322 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DLS+ V +P ++S G + + G V K I R Sbjct: 1 MLDLSVNIGSVPLRSPVIIASGTWGYDESLWREDLLRHVGAVCSKAITESPKDGNPGHRI 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 IG +N + ++E + L+ +IA++ E+E+ + Sbjct: 61 WETPCGLLNSIGLQNTGI--DDFVDEKIPKLKSY-----GVPIIANVSMEDERGLALIVE 113 Query: 122 LVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 + E D IE N SCP + M G SP L + V++ P+ KMTP Sbjct: 114 RLVEVADCVDAIELNVSCPNVDKGCM--SWGVSPVLTSQAVSMVQKIWKGPLWVKMTPQA 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D VA AA+ GAD + NT + ID++ + + ++G+SG AV P+AL Sbjct: 172 PDPEGVARAAEDSGADALVVANTWLGMA-IDVDSRKAV----FDRVVAGFSGPAVFPMAL 226 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ + P+ G GG+ + D ++ GA +++ TG M R+ E++ Sbjct: 227 RLVWQVSSAV---SIPVIGCGGVSSGRDLLSMIMAGATAVELGTG-MFRDIRLPENILRE 282 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 + Y+ + + L+ ++G+A Sbjct: 283 VKAYMTKEKVEDLRSLIGIAKR 304 >UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F860_9ACTN Length = 307 Score = 206 bits (524), Expect = 1e-51, Method: Composition-based stats. Identities = 77/324 (23%), Positives = 130/324 (40%), Gaps = 20/324 (6%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 M ++++ F GVK NP +S G ++ + G + K +P Sbjct: 1 MSQVNMAVDFGGVKMKNPINTASGTFGYGWQFSELMDVSQLGAITTKGCAAEAWPGNPAP 60 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R + +G +N E++ L L +I + G + +++ Sbjct: 61 RMAEVPGGMMNSVGLQNPGV--AAFAEQSGPWLADL--TAKGTQVICQVAGHSTEEYVRA 116 Query: 120 ARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + E A E N SCP + + G+ G +PE + RA ++ + P+ KM P Sbjct: 117 LEMFVELCPWAAGYEINVSCPNIAAG--GAACGSTPEGASEVMRACRKVTDKPLFVKMAP 174 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + E+A A + GADG+ IN++ ++ ID+ + G SG PI Sbjct: 175 --VRIPEIARALEAEGADGLTVINSIPGMS-IDVRTRRSRLSKP----TGGLSGPLCHPI 227 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 A+R + + D PI G+GG+ T EDAAEF+L GA + V + Sbjct: 228 AVRMVWEAANAV---DIPICGVGGVMTGEDAAEFILAGACCVSVGMANFVE-PDASVRIL 283 Query: 298 SGLSHYLADQGFDSLQEMVGLANN 321 L + QG + E++G Sbjct: 284 HELEAWAESQGVKDINELIGAFEC 307 >UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfurococcales RepID=PYRD_AERPE Length = 306 Score = 206 bits (523), Expect = 2e-51, Method: Composition-based stats. Identities = 86/321 (26%), Positives = 143/321 (44%), Gaps = 19/321 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 +LSI+ G++ P +S +G + G G V K++ + P Sbjct: 3 SQPELSISIAGLRLQRPVGNASGILGWEPREARLVEEGGGGFFVAKSVTYQPRKGYPQPH 62 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + +G N E L + E+ +IASI G +W E+A Sbjct: 63 LYPVAGGIVNAVGLANP------GFREASKMLAQTVEEAS-IPVIASIAGGAPGEWVEMA 115 Query: 121 RLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 ++EAG +E N SCP G ++GQ P V AV +P++AK+ Sbjct: 116 STLEEAGVSAVELNLSCPHFAGG--GLELGQDPAAVASVVSAVASTLRIPVIAKLG-YSD 172 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + + A A GA G+ IN+++++ ++ P++ + + G SGK + PIA+R Sbjct: 173 RLVDAASKALEAGARGLTLINSMRAM---KIDVYAKKPVLGNR--VGGLSGKPIHPIAVR 227 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + ++ I GG+E+WEDA EF L GA +QV + G ++ + G+ Sbjct: 228 AVYEVYGETRA---DIFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIVEGV 284 Query: 301 SHYLADQGFDSLQEMVGLANN 321 YL +GF SLQ++VG A+ Sbjct: 285 RRYLWVEGFRSLQDIVGYAHR 305 >UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycetales RepID=A1UMT4_MYCSK Length = 340 Score = 206 bits (523), Expect = 2e-51, Method: Composition-based stats. Identities = 75/336 (22%), Positives = 127/336 (37%), Gaps = 19/336 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS + G++ NP ++SP+ + + D G G VV ++ + Sbjct: 1 MDLSTRYLGLELRNPLLAAASPLSRTLDGVKQLADAGVGAVVLYSLFEEQLRREAADNAR 60 Query: 64 LV----KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + + + + +L L R + + +I S+ G W Sbjct: 61 MATFANETHAESVTYFPSTVGEGDGARRHLRLLERAAAEV-EVPVIGSLNGSTPGGWVRH 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 AR +++AGA IE N SH G +V Q AVK LP+ K++P Sbjct: 120 ARAMEDAGAAAIELNIYQLPGDSHISGREVEQ---RHLDILAAVKDTVDLPVAVKLSPFF 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 E+AL + GADG+ N +ID V S A + Sbjct: 177 SATAEMALRLDQAGADGLVLFNRFLQ-PDIDSETISVTSEVT-------LSVPAEARLPR 228 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 +I +R D ++ G+E D A++LL GA +Q + ++++G + +G Sbjct: 229 TWIALLRGRI---DASLAATTGVEDAGDVAKYLLAGADVVQTASALLRHGPEYAGVLLTG 285 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIV 335 LS +LA + F +L ++ G E Sbjct: 286 LSDWLARKSFHALHQVRGKLAVPFGVDETARERADY 321 >UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia RepID=B1ZSY3_OPITP Length = 352 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 104/297 (35%), Gaps = 31/297 (10%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-FFIANEVSPRFDHLVK 66 + G+ FPN L++ N G+G V TI PR Sbjct: 56 VRAFGLDFPNAIGLAAGFDKNATAWP-ALAALGFGHVEIGTITALAQPGNEKPRVFRFPA 114 Query: 67 EDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-QQWEELAR-L 122 E +GF N E L ++ + +G+++ ++ A+ Sbjct: 115 EKAVINRMGFNNEGS------EAIARRLAHQPGVGQRRIPLGINLGKSKVTDLDQAAQDY 168 Query: 123 VQEAG-----ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVK-RGSTLPMLAKMT 176 + G AD I N S P D + EL+ A + R +P+L K+ Sbjct: 169 LTSFGRLADHADYIALNVSSPNTPGLRQLQDEARVRELLGAISAANRARPRPVPLLLKIA 228 Query: 177 PNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P++ + V A DGI A NT + + G SG+ + Sbjct: 229 PDLTFPQIDAVLAALMEFRFDGIIATNTTLARPG----------PFAAANQAGGLSGRPL 278 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + + I + PI G+GGIE AAE L GA LQ+ TG++ G Sbjct: 279 RRRSTEIINYIARAT-AGKLPIIGVGGIEDGASAAEKLDAGATLLQIYTGMIYRGPW 334 >UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebacterineae RepID=PYRD_MYCTA Length = 357 Score = 205 bits (521), Expect = 3e-51, Method: Composition-based stats. Identities = 77/331 (23%), Positives = 123/331 (37%), Gaps = 31/331 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L+ T GV+FP P L++ + + G+G T+ +PR Sbjct: 47 PVLASTVFGVRFPAPLGLAAGFDKDGT-ALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLF 105 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI-------MGENEQQ 115 L +D + L RL P+ + +I G+ Sbjct: 106 RLA-DDRALLNRMGFNNHGARALAI------RLARHRPEIPIGVNIGKTKKTPAGDAVND 158 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 + AR+V A + N S P V E + AV+ ++ P+L K+ Sbjct: 159 YRASARMVGPL-ASYLVVNVSSPNTPGLRDLQAV----ESLRPILSAVRAETSTPVLVKI 213 Query: 176 TPNIGDMCE--VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D +A A GI A NT S + + G SG Sbjct: 214 APDLSDSDLDDIADLAVELDLAGIVATNTTVSRDGLTTPGVD-------RLGPGGISGPP 266 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 + A++ ++++ + +GGIET +DA E + GA+ LQ TG + G R Sbjct: 267 LAQRAVQVLRRLYDRVGD-RLALISVGGIETADDAWERITAGASLLQGYTGFIYGGERWA 325 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNNIV 324 +D+ G++ L D GF SL E VG A Sbjct: 326 KDIHEGIARRLHDGGFGSLHEAVGSARRRQP 356 >UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacter RepID=C3XDT6_9HELI Length = 357 Score = 203 bits (517), Expect = 9e-51, Method: Composition-based stats. Identities = 71/333 (21%), Positives = 132/333 (39%), Gaps = 35/333 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 + ++L+ G+ F NP L+S N E G+G + ++ PR Sbjct: 47 IHENLAQDIHGLHFYNPIGLASGFDKN-AEAVRPLASLGFGYLELGSVTQMPQDGNEKPR 105 Query: 61 FDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ--- 115 V+E++ +GF N+ L LKE YP + + +G+N+ Sbjct: 106 MFRHVEEESLQNAMGFNNIGARG---------MLAHLKEVYPFCIPLGINIGKNKNIAQG 156 Query: 116 -----WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 +E +++ G D N S P Q+ V++ K + P Sbjct: 157 DSLKNYELSLDTLKDYG-DYFTFNLSSPNTPGLRD----LQNESFVKELMEMAKSTTNKP 211 Query: 171 MLAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 + K++P++ M V AA + G +GI A NT + P+ G Sbjct: 212 IFIKISPDMEIESMLAVCDAAIQNGVNGIIATNTSID------YSLVSNPVKKNDVCFGG 265 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SGKA+ + ++ + + + + +GGI + E + LGA+ +Q+ + ++ Sbjct: 266 LSGKAISTKSKEVLRILGKNFHKKT-TLISVGGIGDSNEVYERIKLGASLVQILSSMIYE 324 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQEMVGLANN 321 G ++ M + L+ L GF + E +G+A Sbjct: 325 GPTLISRMNNELAEKLKADGFKHINEAIGVAIQ 357 >UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PV93_9ACTO Length = 394 Score = 203 bits (516), Expect = 1e-50, Method: Composition-based stats. Identities = 69/344 (20%), Positives = 113/344 (32%), Gaps = 63/344 (18%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 L L+ T GV+FP+P L++ N + G+G V T+ PR Sbjct: 52 LPAGLARTVFGVRFPSPVGLAAGMDKNGIALP-AWRALGFGFVEVGTVTAHPQPGNEKPR 110 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 LV+ + I + L + LAA L L SI G+++ Sbjct: 111 LFRLVESEA-VINRMGFNNLGSAALADRLAAYGPL-----GYPLGISI-GKSKVTPIEDA 163 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST---- 168 + + R + G D N S P D G EL+ + Sbjct: 164 VEDYVTSLRRLYRFG-DYFAVNVSSPNTPGLRSLQDAGHLRELLAALHTEAAALAGSGSG 222 Query: 169 --------------------------------LPMLAKMTPNIGD--MCEVALAAKRGGA 194 P+L K+ P++ + + E+ G Sbjct: 223 SGFGATSGSGAESRSGAESGSGAESGSGSGAVKPILVKIAPDLTEAAIDELLGVCTDAGV 282 Query: 195 DGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDF 254 GI A NT + + + G SG+ + I+ + + + Sbjct: 283 AGIIATNTTIGREALAPADQA------LAAEAGGLSGRPLTEISAKTVAHIHAETG-GAL 335 Query: 255 PISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 PI G+GGI DAA + GA+ +Q+ TG++ G +V Sbjct: 336 PIIGVGGILDPSDAARLIDAGASLVQLYTGLIYRGPGLVRATNR 379 >UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomycetales RepID=PYRD_STRAW Length = 368 Score = 203 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 64/326 (19%), Positives = 114/326 (34%), Gaps = 30/326 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 K+L G++ PF L++ N G+ V T+ R Sbjct: 48 KELRTEAFGLRMHGPFGLAAGFDKNAV-AVDGMSMLGFDHVEIGTVTGEPQPGNPKKRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 LV + +GF N A + + ++ +G+ + + Sbjct: 107 RLVPDRALINRMGFNNEGSAAVAARL--------AAREAVFRTVVGVNIGKTKVVPEEEA 158 Query: 116 WEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST---LP 170 ++ + + AD + N S P L+ A R T +P Sbjct: 159 ADDYVKSTERLARHADYLVVNVSSPNTPGLRNLQATEALRPLLSAVREAADRTVTERRVP 218 Query: 171 MLAKMTPNIGDMCEVALAA--KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 +L K+ P++ D A+A G DGI A NT + + L + + G Sbjct: 219 LLVKIAPDLADDDIDAVADLAVELGLDGIIATNTTIAREGLGLKSEPTLV-----KETGG 273 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG +K +L + ++ + G+GGIE EDA + +L GA +Q + + Sbjct: 274 LSGAPLKARSLEVLSRLYARVGD-RITLVGVGGIENAEDAWQRILAGATLVQGYSAFIYE 332 Query: 289 GYRIVEDMASGLSHYLADQGFDSLQE 314 G + GL+ L + +L + Sbjct: 333 GPFWGRAIHKGLAARLRTSPYATLAD 358 >UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 Tax=Proteobacteria RepID=Q0B324_BURCM Length = 325 Score = 202 bits (513), Expect = 2e-50, Method: Composition-based stats. Identities = 80/332 (24%), Positives = 138/332 (41%), Gaps = 21/332 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRF 61 DLS+ ++ NP +S E TG G +V K++ +PR Sbjct: 1 MADLSVRVGELRLRNPVMPASGCFA--IEYRDALDLTGLGALVIKSVSPVSRPGNPTPRV 58 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 G N I +++ L + + ++AS+ + + Sbjct: 59 A------DAGDGMLNSIGIPSRGIDDYLEHVLPAYTGH-GTPVVASVSADTADAFARACE 111 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + IE N SCP + + M G + + A++ + P+ K+TPN G+ Sbjct: 112 ALSRPDVAAIEANISCPNLEADGM--AFGMDAGMTRQVVDAIRTRTGHPLWVKLTPNAGN 169 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + ++A AA+ GAD I NTV ++ ++ + P + + + G SG ++KPIALR Sbjct: 170 IAKIAQAAQDAGADAIVMGNTVLGMS---IDVRTRRPSLG--NVMGGLSGPSIKPIALRL 224 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q P+ G GGI + DA EFLL GA+ +QV T ++ + GL Sbjct: 225 VHQCYRAV---SIPVIGCGGIRSAADAIEFLLAGASAVQVGTASF-RDPGVMRTIIDGLE 280 Query: 302 HYLADQGFDSLQEMVGLANNNIVPAEDLDRSY 333 + AD+G ++ + G + +E R Sbjct: 281 QFCADEGIGAIASLTGQVRLDAELSERWQRFC 312 >UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria RepID=PYRD_ANASK Length = 364 Score = 201 bits (512), Expect = 3e-50, Method: Composition-based stats. Identities = 65/332 (19%), Positives = 116/332 (34%), Gaps = 30/332 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L++ G+ F P L++ + + G+ V TI PR Sbjct: 43 PALAVRCMGLDFDGPVGLAAGFDKGDVALP-GLFGLGFSHVEIGTITPRPQPGNDRPRLF 101 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 L + +GF N E L L + ++ G+N+ Sbjct: 102 RLPEHRALLNRMGFNNEGM------EACARRLAALPPAARLGPVGINV-GKNKVTPNEDA 154 Query: 116 WEELARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-LPML 172 + ++ AD + N S P + L+ R + + P+L Sbjct: 155 AADYLACIERLHPYADYLVVNISSPNTPGLRQLQERDALDRLLRACVRHLAERAPGKPLL 214 Query: 173 AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ + E A GA GI A NT S ++ + + G S Sbjct: 215 VKLAPDLSPEALDEAVDVAIAAGAAGIVATNTTLSRAGVERHPRAA--------EAGGLS 266 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G ++ +A +++ PI G+GG+ E A + GA +Q TG++ G Sbjct: 267 GAPLERLATDVVRRCYARA-AGRVPIVGVGGVMDAEGAYAKIRAGATLVQAYTGLIYGGP 325 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 V + +GL+ L F +L + +G + Sbjct: 326 GFVGRVNAGLARLLERDEFSTLSDAIGADHRQ 357 >UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobiluncus RepID=C2BWU0_9ACTO Length = 348 Score = 201 bits (512), Expect = 3e-50, Method: Composition-based stats. Identities = 66/309 (21%), Positives = 114/309 (36%), Gaps = 42/309 (13%) Query: 11 CGVKFPN--PFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKE 67 G KF P L++ A G+G + TI PR + ++ Sbjct: 64 AGTKFRTYGPLGLAAGMDKE-ARAIAMWDALGFGFMEIGTITPLPQPGNDRPRLWRIPQQ 122 Query: 68 DT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQWE 117 +GF N A LRR + +Y ++++I + +G+N + Sbjct: 123 RALRNAMGFNNEGARAAAR------RLRRWRAEYGERIIIGANIGKNKVTPPEKAPADYR 176 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV--KRGSTLPMLAKM 175 ++ R++ D + N S P V +V+ R + + S LP+ K+ Sbjct: 177 KVTRVLAAL-VDFLVINVSSPNTPGLRDLQAVSSLLPIVKAVQRELESQGLSELPVFVKI 235 Query: 176 TPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 P++ D+ VA G G+ A NT + G SG+ Sbjct: 236 APDLVDEDIAAVAQLTMDEGLTGVVATNTT----------------IKHDLGAGGMSGEP 279 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 ++ AL ++ +R H + I G+GGI T EDA L GA ++ + + G Sbjct: 280 LRNRALEVVKLLREHL-SPEKTIIGVGGITTPEDARAMLAAGANLIEGFSAFIYEGPAWP 338 Query: 294 EDMASGLSH 302 + L+H Sbjct: 339 AHLNRELTH 347 >UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer subunit/dihydroorotate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JFH0_9ARCH Length = 589 Score = 201 bits (511), Expect = 4e-50, Method: Composition-based stats. Identities = 82/321 (25%), Positives = 146/321 (45%), Gaps = 22/321 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFD 62 +L+ CG+ F NP ++ G ++ + G G VV K++G +P F Sbjct: 287 PELATEVCGIIFTNPIANAAGF-GLSGKLLYRYAVAGAGAVVTKSVGLYEQEGYPNPTFI 345 Query: 63 HL-VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + +G N I ++ LE A Y D LI SI G+N ++ E+A+ Sbjct: 346 EIAPRSYVNAMGLPNPGII-DYGLEIGDAK-------YADVPLILSIFGKNVEECREVAK 397 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST-LPMLAKMTPNIG 180 + + DM+E N SCP + V P+L+ + ++ P+ K++PN+G Sbjct: 398 IATKYPIDMLEFNASCPH----SDFVAVENQPKLLRSIIKEIRAIVHPKPIAVKISPNVG 453 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 D +A+ ++ GAD I AINTV + ++ ++ I+ + G SGK + Sbjct: 454 DPAGLAMTLEKAGADAITAINTVIARP---VDNRLDTHILGNPTGYGGKSGKDLTVGGKE 510 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + + PI +GGI + +D ++ GA+ QV + ++ I + L Sbjct: 511 IVFNLYKELK---IPIIAVGGIFSAKDVIDYAKNGASMFQVGSALVSEDLEIFSTIKKEL 567 Query: 301 SHYLADQGFDSLQEMVGLANN 321 YL +G+ ++ EMVG A+ Sbjct: 568 KAYLGAKGYKNIGEMVGEAHR 588 >UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococcus RepID=Q5HL43_STAEQ Length = 354 Score = 201 bits (511), Expect = 5e-50, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 126/318 (39%), Gaps = 25/318 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ G+ F NP L++ +C E+ + G+G + I PR L Sbjct: 49 LTQHIHGISFDNPIGLAAGFDKSC-EVPKALENIGFGAIELGGITPKPQPGNPKPRMYRL 107 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN-EQQWEELAR 121 +++D +GF N + + L+ LR P + + + E ++++ + Sbjct: 108 LEDDALINRMGFNN------KGMNKALSNLRNHSCSIPVGLNVGVNKTTSYENRYQDYIK 161 Query: 122 LVQEAGAD--MIECNFSCPQMTSHAMGSDVGQSPELVEKYCR-AVKRGSTLPMLAKMTPN 178 ++ D N S P + D + L + K +P+ K+T + Sbjct: 162 VIDTFKNDVSFFTVNISSPNTENLQNFHDEDEFSMLCDALNSFKAKNNINVPIFLKLTSD 221 Query: 179 IG-DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + D + L + DG+ NT + ++ K G SG+ + Sbjct: 222 MELDGFKKILPSITDTFDGVMLANTTRQRDGLNS---------KNKIQEGGLSGRPLFQR 272 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 L+ ++ +F I G GGI + EDA + L GA+ LQ+ + ++ G + + M Sbjct: 273 NLQLVKYAYQQTR-GNFLIIGTGGIFSSEDAIKMLRNGASLLQIYSSLVIEGPGLTKKMN 331 Query: 298 SGLSHYLADQGFDSLQEM 315 ++HYL G+ ++ ++ Sbjct: 332 KEIAHYLTRHGYANVSDI 349 >UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospirillum RepID=Q2W4R2_MAGSA Length = 329 Score = 201 bits (511), Expect = 5e-50, Method: Composition-based stats. Identities = 64/319 (20%), Positives = 128/319 (40%), Gaps = 16/319 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ + G+ NP +S+SP+ + D G +V +I + Sbjct: 1 MNLATRYLGLDIKNPLVVSASPLALDLGNSRRLEDCGAAAIVLPSIFQEDIENEIDEIER 60 Query: 64 LV-KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 LV + ++ + A + L +RR +E + +IAS+ G W E A Sbjct: 61 LVCEGNSEAFSYFPANISANAGPKNYLDLIRRTREAL-EIPVIASLNGTTRTGWTEYAAQ 119 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 Q+AGA IE N G++V + VK ++P+ K++P + Sbjct: 120 SQQAGASAIELNVYLLPTDMDMSGTEVES---RYLEILEDVKSAVSIPVSMKLSPYFSSV 176 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + G DG+ N +IDL++ + + S K + L +I Sbjct: 177 GNMVKVLDDHGVDGVVLFNRFYQ-PDIDLDELKLVRDLK-------LSHKGEIRLPLLWI 228 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + I+ G++T + ++L +GA + T+ +M++G ++ + GL Sbjct: 229 ATLAGKIKAS---IAASSGVQTAAEVVKYLFVGADVVMTTSALMRHGVDYMKTLHDGLIA 285 Query: 303 YLADQGFDSLQEMVGLANN 321 L ++ +S+ ++ G + Sbjct: 286 ELKEREAESVADIRGKMSR 304 >UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12 Tax=Chlorobiaceae RepID=Q3B2I1_PELLD Length = 331 Score = 201 bits (510), Expect = 6e-50, Method: Composition-based stats. Identities = 78/308 (25%), Positives = 139/308 (45%), Gaps = 20/308 (6%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDTG 70 G+ +P L+S V E+C + GG+V K I R Sbjct: 37 GLSLKSPVMLASGTVSYGEELCRLTDLSKIGGIVTKAISLEARAGNPPQRIAETPSGMIN 96 Query: 71 FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA-GAD 129 IG N+ + + E + L+ L ++ +I G + ++ E+ + G D Sbjct: 97 AIGLANVGI--DRFISEKVPFLQTL-----GTAIVVNIAGRSIDEYAEVVSRLDAVPGLD 149 Query: 130 MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAA 189 E N SCP + M +G SP+ + ++ + ++ K+TPN+ + +A+AA Sbjct: 150 GYEINLSCPNVKGECM--IMGVSPDATREIVTELRSITGRHLMIKLTPNVTSISAIAIAA 207 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 ++ GAD ++ INT+ + ID ++ + K+ G SG A+KP+AL + ++ Sbjct: 208 EKAGADSVSLINTLVGMA-IDWKKRRPL----LKNVTGGLSGPAIKPVALAKVWEV---N 259 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 PI G+GGI +++DA EFL+ GA +Q+ T I E +A+ + + G Sbjct: 260 NAVSIPIVGMGGIASFDDAMEFLVAGAGAVQIGTMNFVQ-PDIGEKIATAMEAFFCAPGA 318 Query: 310 DSLQEMVG 317 S++ G Sbjct: 319 PSMEAFRG 326 >UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter vinelandii DJ RepID=C1DSD9_AZOVD Length = 332 Score = 200 bits (509), Expect = 8e-50, Method: Composition-based stats. Identities = 75/318 (23%), Positives = 131/318 (41%), Gaps = 17/318 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 +L+ T+ G+ NP S+SP + + D G G VV ++ + + Sbjct: 1 MNLTTTYLGLSLRNPLIASASPQNAELDHLHRLDDAGIGAVVLPSVFQEQLEAGANDYAS 60 Query: 64 LVKEDTGFIGFKNMEQIAEHPL--EENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + F + + + E +LA + R K + +IAS+ G + W A Sbjct: 61 IGAACSDVPAFLPPVEGGPYGMIPESHLALIMRAKAELS-VPVIASLNGASANHWTHYAA 119 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 L++EAGAD +E N + G+ V Q + AV+R +P+ KM P Sbjct: 120 LLEEAGADALELNLYFVPVDPLEPGTAVEQ---RYLEVLAAVRRTVKIPVAVKMPPYFSA 176 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + +A GGADG+ N +IDL + + + S + L + Sbjct: 177 IGNMASRLLEGGADGLVIFNRYLQ-PDIDLQRLQPISTLE-------LSSPGEMRLPLLW 228 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 I + + ++ GG+E E ++LL GA T+ T I+++G V + GL Sbjct: 229 IALLAGRVKGS---LAASGGVEDVEQVVKYLLAGADTVMTTAAILRHGPAHVHTLLCGLE 285 Query: 302 HYLADQGFDSLQEMVGLA 319 +L + SL+ + G Sbjct: 286 AWLQSRRGQSLERIRGQM 303 >UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=Plasmodium (Vinckeia) RepID=Q7RLG4_PLAYO Length = 512 Score = 200 bits (508), Expect = 8e-50, Method: Composition-based stats. Identities = 65/342 (19%), Positives = 124/342 (36%), Gaps = 43/342 (12%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKE 67 + F NPF +++ N G+ + TI PR V+ Sbjct: 180 DIKNLNFINPFGVAAGFDKNGI-CIDSILKLGFSFIEIGTITPKPQKGNDKPRIFRDVEN 238 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKED---YPDKVLIASIMGENE------QQWEE 118 + I I + ENL + R+ +E+ ++ SI G+N+ + Sbjct: 239 KS-IINACGFNNIGCDKVTENLISFRKKQEEDKLLSKHIVGVSI-GKNKYTENIVDDLKY 296 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS----------- 167 + AD I N S P + + ++ + + + Sbjct: 297 SIYKIARY-ADYIAINVSSPNTPGLRDNQESNKLKNIILFVKQEINKIEESGHNGENFWM 355 Query: 168 ----TLP-MLAKMTPNIGDMCE--VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIV 220 P + K+ P++ + + +A G DG+ NT + +I Sbjct: 356 NTTKKKPLVFVKLAPDLENSEKKKIAQVLLDTGIDGMIISNTTINKMDIK---------- 405 Query: 221 NGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQ 280 + + G SGK +K ++ I M + + PI GGI T DA E + GA+ Q Sbjct: 406 SFEDKKGGVSGKKLKDLSTNLISDMYIYTNKQ-IPIIASGGILTGADALEKIEAGASVCQ 464 Query: 281 VTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNN 322 + + ++ G + + ++ L +G+ +L+E +G +NN Sbjct: 465 LYSCLVFNGVKSAIQIKREFNNALYQKGYYNLREAIGKKHNN 506 >UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmida RepID=A7AUQ8_BABBO Length = 415 Score = 200 bits (508), Expect = 1e-49, Method: Composition-based stats. Identities = 66/351 (18%), Positives = 124/351 (35%), Gaps = 35/351 (9%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRF 61 + V F NP +++ E+ + G+G V T+ P Sbjct: 59 PPVIQSRLKDVVFFNPIGMAAGYDK-QVEVPLQILRMGFGFVEVGTVLPLPQEGNPKPVM 117 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDK--VLIASIMGENEQ----- 114 L + I + + L +R+ + P +I +G+N Sbjct: 118 FRL-HDSKALINCCGFNSVGLEVAKARLKRVRKKQASDPLTKDFMIGVSVGKNRTGDILA 176 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV----------- 163 + V AD I N S P + ++ A+ Sbjct: 177 DTVNAVKGVAPY-ADYIAINVSSPNTPNLRDNQKREPLIAVISAARSALEIVNTEIKSKG 235 Query: 164 ----KRGSTLPML-AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIG 216 +P+L K++P++ ++ ++A + DGI A NT + N+ + Sbjct: 236 AEFNNTTKKVPLLLIKISPDVSRQELEDIADISLTHHVDGIIATNTTITRDNVVPSDLKT 295 Query: 217 MPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGA 276 + G SG+ +K ++ + + + E PI GGI T +DA E + GA Sbjct: 296 -----AGNPKGGLSGRPLKTMSKKIVYDLYELTE-GKIPIIACGGISTAQDALEMIEAGA 349 Query: 277 ATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE 327 + Q+ T ++ G I M +GL+ L +G+ ++ E +G + P Sbjct: 350 SLCQIYTALVYEGPGIPSRMKNGLADLLMKKGYLNVSEAIGAEHRRRKPTP 400 >UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLU5_9BACT Length = 302 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 77/316 (24%), Positives = 145/316 (45%), Gaps = 26/316 (8%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DL++ +KF NP ++ P E +A + G GG+V KT+ A P Sbjct: 1 MADLTVKLGKLKFINPVLPAAGPNVMRLEQMLEAVERGAGGIVTKTVSREPAVYPKPCIS 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + G N E ++ P + ++KE LI SI G + + EL + Sbjct: 61 KGPCD-----GLLNCETWSDRPWRSYIDDYVKVKET--GVPLICSI-GYSPEDVAELGKA 112 Query: 123 VQ-EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 ++ E G D++E VG++ + +++ A++ + P+ K++P+ + Sbjct: 113 LEAEVGPDVVEF-----------STHYVGKTLDPLKRVAEALRGSVSCPVWMKVSPSTPN 161 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+A DG A+N+V +D + P + + SG A+ +AL Sbjct: 162 IPEMAKVMSDY-VDGFVAVNSVG--PALDFDIDKPKPRLGTEDGHGWLSGPAITGVALYA 218 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q+ +D P+ G+GGI T EDA +F++ GA+ + + + ++ G I +AS +S Sbjct: 219 VYQIS---HSQDKPVVGVGGIRTGEDAVKFIMAGASLVGICSEAIRRGTGIYGKIASEIS 275 Query: 302 HYLADQGFDSLQEMVG 317 ++ +G+ SL ++ G Sbjct: 276 DWMDRKGYGSLDDIRG 291 >UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XQ80_HIRBI Length = 362 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 58/333 (17%), Positives = 115/333 (34%), Gaps = 41/333 (12%) Query: 3 TKDLSIT--FCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSP 59 ++ L + G+ PNP +++ N G G V T+ P Sbjct: 44 SERLKVHLPISGLDLPNPLGIAAGFDKNADAFVPSLA-LGCGFVECGTVTPQLQDGNPKP 102 Query: 60 RFDHLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE---- 113 R L ++ +GF N + + RLK ++ ++ + +G N+ Sbjct: 103 RLFRLKEDGGVINRMGFNNSGLDS---------FVHRLKNGAANQGVVGANVGANKTSEG 153 Query: 114 ----QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-----K 164 + + + V + A I N S P + L+ + + Sbjct: 154 EKRVGDYVDGIKAVWQYCA-YITLNISSPNTPGLRGLQNKSDLSALLTAASETILEMEDR 212 Query: 165 RGSTLPMLAKMTPNIGD--MCEVALAAKRG-GADGIAAINTVKSITNIDLNQKIGMPIVN 221 + P+ K+ P+I + + ++ G G+ NT + ++ Sbjct: 213 HKTKRPVFLKIAPDIDEEAIRDIVDTVLLAKGMTGLIVSNTTIERPSFLQSE-------- 264 Query: 222 GKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQV 281 G SGK + + + ++Q+ I G GGI + A + GA Q+ Sbjct: 265 NAKQTGGLSGKPLFEKSTQVLKQVAR-IADGQLDIIGAGGIHDAKSAYLKIRAGAHCFQL 323 Query: 282 TTGIMQYGYRIVEDMASGLSHYLADQGFDSLQE 314 + ++ G ++ ++ +GL L GF L E Sbjct: 324 YSALVYEGAALIPEILNGLDQLLEADGFSQLSE 356 >UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobacteraceae RepID=D1B1W1_SULD5 Length = 355 Score = 199 bits (507), Expect = 1e-49, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 126/328 (38%), Gaps = 40/328 (12%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 K L T F NP L++ N M G+G + + T+ PR Sbjct: 52 KRLEQTLFDRTFHNPIGLAAGFDKN-ATMIKMLTALGFGHIEYGTMTPEPQSGNAKPRCF 110 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE------- 113 +E++ +GF N +RL+ YP +A+ +G+N+ Sbjct: 111 RFPEEESIQNAMGFNNEGMH---------KIAKRLESLYPFATPLAANIGKNKITSAENA 161 Query: 114 -QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 + +E+L + ++ +D + N S P Q+ +++ K + P+L Sbjct: 162 LKDYEKLIKRFKDV-SDFLVVNISSPNTPGLRDL----QNEAFIKELFMMAKELTCKPVL 216 Query: 173 AKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ + E+ A GA GI A NT ++ G S Sbjct: 217 LKIAPDLEIKEAIELCSCALENGAKGIVATNTTID-----------YSLLPNAKDFGGIS 265 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 GK + + R + + + + +GGI++ E+A L GA+ LQ+ + + G Sbjct: 266 GKVLCEKSFRMFEGIAKEFFGKT-TLISVGGIDSAEEAYRRLKAGASLLQIYSAFIFKGP 324 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGL 318 + + G+ + GF + E++G Sbjct: 325 SLNRTINLGILERMERDGFHHISEVIGC 352 >UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular organisms RepID=PYRD_YEAST Length = 314 Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 135/324 (41%), Gaps = 17/324 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-FFIANEVSPR 60 +T L+ F + NPF +S + + ++ G + K+ PR Sbjct: 1 MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKV-LIASIMGENEQQWEEL 119 + + +G N ++ L+ + +++YPD + S+ G + + L Sbjct: 61 YISVPLGSINSMGLPNE------GIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNL 114 Query: 120 ARLVQEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 R +Q++ + I E N SCP + V +L ++ V P+ K+ P Sbjct: 115 LRKIQDSEFNGITELNLSCPNVPGKP---QVAYDFDLTKETLEKVFAFFKKPLGVKLPPY 171 Query: 179 IG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 +A + +IN++ + ID+ ++ +V K+ G G+ VKP Sbjct: 172 FDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKES--VVVKPKNGFGGIGGEYVKP 229 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 AL ++ T + + G GGI++ +DA E LL GA+ LQ+ T + + G +I E + Sbjct: 230 TALANVRAFYTRLR-PEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERI 288 Query: 297 ASGLSHYLADQGFDSLQEMVGLAN 320 L + +G+ S+ + G N Sbjct: 289 EKELKDIMEAKGYTSIDQFRGKLN 312 >UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECL7_9ACTN Length = 302 Score = 198 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 76/319 (23%), Positives = 133/319 (41%), Gaps = 20/319 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 +++ F GVK NP ++ G ++ + G + K +PR + Sbjct: 1 MAVDFGGVKMQNPINTAAGTFGYGWQFQNFFDVSQLGAITTKGCAAEPWPGNPAPRMAEI 60 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 +G +N E+ L +L +D +I + G + ++ + Sbjct: 61 PGGMINSVGLQNPGV--AAFARESGPWLEQLSKD--GCQVICQVAGHSVDEFVRALEMYV 116 Query: 125 EAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 E A E N SCP + + G+ +G +PE A ++ + P+ KM P ++ Sbjct: 117 ELCPWAAGYEINVSCPNIAAG--GAAMGSTPEGASSVMAACRKVTDKPLFVKMAP--VNV 172 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E+A A + GADG++ IN+++ + ID++ + G SG IA+R + Sbjct: 173 AEIAKALEAAGADGLSVINSIQGMA-IDVHTRKSRVAKP----KGGLSGPLCHHIAVRMV 227 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 ++ D PI+G+GG+ T EDAAEF+L GA + V +A L Sbjct: 228 WEVAQAV---DIPINGVGGVMTGEDAAEFILAGATCVSVGMANFV-DPCASLKIAHELEA 283 Query: 303 YLADQGFDSLQEMVGLANN 321 + QG + E+VG Sbjct: 284 WAESQGVKDINELVGAFEC 302 >UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CE91_THET1 Length = 376 Score = 198 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 61/326 (18%), Positives = 111/326 (34%), Gaps = 31/326 (9%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 L ++ GV+ NP + + + Y G+ V T+ PR Sbjct: 56 PRLKVSLAGVQLENPLIVGAGWDKSGIS-IRALYALGFASVEVGTVTPRPQPGNPRPRQF 114 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ------- 115 L I + NL + + + + SI G+N+ Sbjct: 115 VLSSGV--VINRLGFNNPGADAVAANLESYK-----SDNIPVGISI-GKNKDDPEDRAPL 166 Query: 116 -WEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-GSTLPMLA 173 + E+AR + G N S P + + + G+ P+ Sbjct: 167 AYAEVARKLYPYG-SYFVINVSSPNTPGLRSLQRKEALLSIAQSVLDVMDSYGARKPLFI 225 Query: 174 KMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K+ P + ++ E+ + G G+ A NTV D+ + G + G SG Sbjct: 226 KIAPELSYQEVDEILDVVLQLGLAGVVATNTV---ALGDVKARYGE---GWRLQPGGLSG 279 Query: 232 --KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 + + ++ + + + + I G+GG++ A E +L GA +QV T I G Sbjct: 280 DDEVFRHMSTSKVAYIYSQTK-GSIDIIGVGGVKDAHTALEKILAGATAVQVVTAIRSEG 338 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEM 315 + GL +L G S+ + Sbjct: 339 LAVAARTNLGLLEWLDKNGVKSISNV 364 >UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Staphylothermus marinus F1 RepID=A3DM44_STAMF Length = 301 Score = 198 bits (502), Expect = 5e-49, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 133/318 (41%), Gaps = 18/318 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL+ G+ F +P +S + + TG G+V KT+ P Sbjct: 1 MDLTTKVTGIVFKHPIMNASGILASSINGVGILAKTGVAGIVTKTLTLKPREGYLPPI-- 58 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 + D G + + + + + + I SI G + ++++ LA Sbjct: 59 TIPLDYGLLNAVGLANPGIDAVNVLVEEIHKY-----GLPAIVSIGGRDPREFQILAEKA 113 Query: 124 QEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 +A + +E N SCP G D + E+++ V S +P+ K+ + Sbjct: 114 LDARPEALELNLSCPHTPG--FGVDTVATDEVLKHVALNVSSVSNIPVWGKLG-FSRRII 170 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 + G D + INT+ + ++ +G P++ G SG A+ P+A+ + Sbjct: 171 RESEILLNNGVDAVVLINTLPGMF---IDVYVGKPVLTH--GFGGLSGPAIHPVAVYSVY 225 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 ++ I G+GG+ W+ + E LL GA +Q+ TG GY IV ++ G+ Y Sbjct: 226 KVYEELGAE---IIGVGGVIDWKTSVELLLAGAKAIQIGTGFYMVGYNIVNNILDGIKKY 282 Query: 304 LADQGFDSLQEMVGLANN 321 + ++GF + +++G A+ Sbjct: 283 MEEKGFTRISDIIGYAHR 300 >UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6B3_9ACTN Length = 309 Score = 198 bits (502), Expect = 5e-49, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 130/324 (40%), Gaps = 22/324 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPR 60 + + G+ NP ++ + + G + K A +PR Sbjct: 4 TPVSMEVNLGGIHMKNPVNTAAGTFAFGQQFEKFYDVSQLGAITTKGASIKPWAGNPAPR 63 Query: 61 FDHLVKEDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + +G +N + L L++ +I + G + ++ Sbjct: 64 MCEVTSGIINSVGLQNPGVNGLINTAGAYLTGLQQKNCQ-----VICQVAGHSIDEYVAA 118 Query: 120 ARLVQE--AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + +E + A E N SCP + G+ +G +P+ + R ++ + P+L KM P Sbjct: 119 LEVFEEKASFAAGFEINISCPNIACG--GAAMGSTPQGAAEIMRRLRPLTKRPLLVKMGP 176 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 ++ E+A A + GAD ++ IN++ + ++ ++ + G+SG A+ PI Sbjct: 177 --VNIPEIARALESEGADALSLINSIPGMA---IDTTTYKSKLSRPT--GGFSGPAIHPI 229 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 A+R + + + P+ GIGGI T +AAEF+L GA + V + Y + Sbjct: 230 AVRMVWEAHKAVK---IPLCGIGGITTGLEAAEFILAGATAVSVGLANL-YDPMSAPRIL 285 Query: 298 SGLSHYLADQGFDSLQEMVGLANN 321 L + QG + +++G Sbjct: 286 HELCDWAQKQGVTRISDLIGACKC 309 >UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9F3A8_SORC5 Length = 407 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 120/330 (36%), Gaps = 27/330 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 +++ G+ FP+P ++ G+G V T+ P Sbjct: 77 RIAVRTMGLDFPSPLGVAGGFDK-DARRARALAALGFGFVELGTVTAQPQAANPPPNLFR 135 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN----------- 112 L + I + E L L R + SI G++ Sbjct: 136 LPADRA-LINRLGFPNQGAARVTERL--LGRGGTAAVGVPVGISI-GKSRVAPLDPIEPA 191 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-STLPM 171 + R + A AD + N S P + L+ R + + LP+ Sbjct: 192 IDDYLASFREARRA-ADFVVINVSSPNTKDLRAMQGPAIARALLSAIARENRAAGAPLPL 250 Query: 172 LAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 L K+ P++GD + + + G G+ A NT + + P G Sbjct: 251 LIKVAPDLGDEELEALLAVVEEVGLAGVIATNTTVRRDGLATS-----PADVEAMGAGGL 305 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 SG ++ +L ++++R + + G GGIE+ E A + L GA +Q+ TG + G Sbjct: 306 SGPPLRQRSLAMVRRIRARLGS-NVTVIGAGGIESAEHAMDQLQAGADLVQIYTGFIYGG 364 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLA 319 + ++A GLS +A G S+Q++V Sbjct: 365 PLLPAEIARGLSDLVARSGARSIQDLVSRP 394 >UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=B8EIT2_METSB Length = 337 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 67/328 (20%), Positives = 122/328 (37%), Gaps = 18/328 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DL + G+ P S+SP+ + + D+G G VV ++ E + D Sbjct: 1 MDLRTRYLGLSLRTPLIASASPLSGDVGLIRQMEDSGAGAVVLPSLFQEQIEEEARAADE 60 Query: 64 L----VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 L + L + R + D +IAS+ G W + Sbjct: 61 LARIGADSSPEASSYFPAVVTYNSGPHGYLDLVARARAAV-DIPVIASLNGTTVAGWVDY 119 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 ARL+++AGA +E N G AV+ LP+ K+ P Sbjct: 120 ARLIEQAGATALELNIYRIASGPGVTGGQAEAD---CVALLEAVRSRVKLPVAVKLHPYF 176 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 + A GADG+ N + +IDL + SG + L Sbjct: 177 SAFGDFAQQLDHAGADGLVLFNRLYQ-PDIDLLRLAWKNDAT-------LSGAGEIRLGL 228 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 ++ + ++ G++T E+ +++L GA + + ++++G + + SG Sbjct: 229 LWLSVLSGRL--PHASLAAGTGVDTAEEVIKYILAGANAVMTASSLLRHGPGHLRTLVSG 286 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAE 327 L +L+ +GF S+ + GL + +E Sbjct: 287 LETWLSTRGFASVSAITGLMRPSHPDSE 314 >UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidobacteriaceae RepID=D2RBF2_GARVA Length = 333 Score = 196 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 129/302 (42%), Gaps = 19/302 (6%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVK 66 GVK+ N +S + G + K + SPR Sbjct: 37 TQVAGVKWKNMVGTASGTF-QLAACRRFYDVSQLGAICTKGVSPVPWEGNPSPRTAESPS 95 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 +G +N +H L + L L+++ ++I ++ G ++ + ++ + ++ Sbjct: 96 GMVNAVGLQNPGV--DHYLVDELPKLKKM-----GALVITNVAGHSDDDYAQVVEKLADS 148 Query: 127 GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVA 186 ADM+E N SCP +T M VG P + + + ++ + PM+ KMTPN+ D+ + Sbjct: 149 AADMLEINVSCPNVTHGGM--SVGTDPVALHRLIKRLRAMTDKPMIVKMTPNVTDIVSIC 206 Query: 187 LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 AA GAD ++ INT+ + ++ + G PI+ ++ G SG A+ PI L F+ ++R Sbjct: 207 KAAVDAGADALSMINTLVG---LRIDIRTGEPIIANRT--GGVSGPAIFPIGLGFVWRVR 261 Query: 247 THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD 306 G I++ E A E+L GA ++V + +A L L Sbjct: 262 QAMPDIPIIGIGG--IDSGEKALEYLYAGANAVEVGAAALV-DPTAPIRIARELDDLLDS 318 Query: 307 QG 308 + Sbjct: 319 RP 320 >UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes RepID=B2B417_PODAN Length = 482 Score = 196 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 64/349 (18%), Positives = 108/349 (30%), Gaps = 54/349 (15%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L++ GV+ NP +S+ E+ + G G V I PR + Sbjct: 127 LAVNVFGVELSNPIGISAGLDK-DAEIPDPLFALGAGVVEVGGITPLPQEGNPKPRVFRV 185 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAAL------------RRLKEDYPDKVL-------- 104 V D G I + + +L + + + + Sbjct: 186 VSTD-GLINRYGLNSKGADAVAAHLRERLRTFARSIGFTEKEMLDGEAGVPVGSLKDGRL 244 Query: 105 ----IASIMGENEQQWE----ELARLVQEA--GADMIECNFSCPQMTSHAMGSDVGQSPE 154 IA +E+ E + V AD++ N S P G Sbjct: 245 LCVQIAKNKKTDEKDVEAVKKDYVTCVNRLAPYADVLVVNVSSPNTPGLRDLQATGPLTA 304 Query: 155 LVEKYCRAV---KRGSTLPMLAKMTPNIGD---MCEVALAAKRGGADGIAAINTVKSITN 208 L+ KR ++ K++P+ D M V A G DG+ NT K T Sbjct: 305 LLSAVVEEAQKTKRKVKPRVMVKVSPDEDDDSQMEGVVQAVWMSGVDGVIVGNTTKKRTG 364 Query: 209 IDLNQ-KIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDF------------- 254 + ++ GYSG A+ L + + R + Sbjct: 365 LVPKGVRLTSQEQKNIMEDGGYSGPALFNQTLNLVGRYRKMLDSYSLKTEGLGDAFNKNQ 424 Query: 255 -PISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 I GGI ++A + L GA+ V TG++ G + + + + Sbjct: 425 KVIFATGGITNGDEALKVLNAGASVAMVYTGMVYGGSGTITRIKNEMRE 473 >UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SLA1_9BACT Length = 328 Score = 195 bits (495), Expect = 3e-48, Method: Composition-based stats. Identities = 77/353 (21%), Positives = 134/353 (37%), Gaps = 34/353 (9%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVS---- 58 D+ +F G+ NP + SS + + E D G VV K++ + Sbjct: 1 MSDIRTSFMGLTLKNPVIVGSSTLTDTPEKIKALADNGAAAVVLKSLFEQEVRNLKDSAQ 60 Query: 59 -----PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE 113 P + D G + + + E L +R K D +IASI E Sbjct: 61 CCNYHPEAYYYDMSDAGML----------YGISEYLQLIRDAK-LATDIPVIASICCEKA 109 Query: 114 QQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 W+ + AGAD +E N + + +D+ + + VK + LP Sbjct: 110 AWWKTYPERIANAGADALELNINMLSLHGAKSPADIYKD---TLQIIHTVKNTTDLPFSV 166 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K++P + + K GA G+ + + + I+ N P S YS Sbjct: 167 KLSPYCCSIPYLVKMLKEEGAKGVTLFSRLFEL-GINTNTFECEP-------ASYYSSPE 218 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 LR++ + E D I G GI T + + ++ GA +Q+ + I + G I+ Sbjct: 219 ETFKVLRWVHLVS---EQVDIEICGNTGIHTSREIIQHIIAGAGAVQMVSSIYKNGPEII 275 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVG 346 L Y+ D+ F++L E+ G + + L + + + R LD +G Sbjct: 276 RTCLEELEQYMFDRQFNTLHELKGFLSTKEKDFDLLYFNSLTHDRFQLDSHMG 328 >UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglobaceae RepID=PYRD_ARCFU Length = 299 Score = 195 bits (495), Expect = 3e-48, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 119/284 (41%), Gaps = 22/284 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L G++ NP L+S +G+ G VV K++G Sbjct: 4 LETEIGGLRMKNPLMLASGIMGSKVHSLNLIARD-AGAVVTKSVGVEEREG-----YRNP 57 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 G N +A ++ L+ + L+ S+ G + +++ +L Sbjct: 58 TVVNWKCGLINAVGLASPAAKDFAEELKDY---TNEAPLLISLYGHSVEEFSDLVDTFDS 114 Query: 126 A--GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 A E N SCP + G D+G EL +K + P+ AK++ + D Sbjct: 115 ALPYLHGYELNLSCPHVKG--AGLDIGMDLELSAAIVEELKGKTKNPVFAKLSA-MHDYL 171 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 ++A + G DGI NT++ + ++ G P+++ + G SG A+KPIAL+ + Sbjct: 172 KLAKVLEDAGVDGITISNTLRGM---KIDIMSGKPVLS--NLSGGVSGPAIKPIALKCVY 226 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 + E PI G GGI ++ED EF++ GA +Q+ + + Sbjct: 227 DLYKEIE---VPIVGCGGITSFEDVLEFIMAGARAVQIGSAVYY 267 >UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 Tax=Actinomycetales RepID=A0LUF8_ACIC1 Length = 351 Score = 195 bits (495), Expect = 3e-48, Method: Composition-based stats. Identities = 88/322 (27%), Positives = 140/322 (43%), Gaps = 21/322 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 DL+ V PNP +S E+ + G VV K+I +PR Sbjct: 25 VDLTTQLGSVVLPNPVTTASGCAAAGRELGQFVDVSTLGAVVTKSIMLAPRAGRPTPRMA 84 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW-EELAR 121 IG + + LE +L L I SI G + ++ AR Sbjct: 85 ETPSGLLNGIGLQGPGI--DEFLEHDLPWLAEHGARA-----IVSIAGSSVGEYAALAAR 137 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPMLAKMTPNI 179 L A +E N SCP + G P AV+ + +P+ AK++P++ Sbjct: 138 LRGAAPVVALEVNISCPNVEDR--GQVFACDPRAASAVLAAVREAADPAVPVFAKLSPDV 195 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ VA A GADG++ INT+ + ++ + P ++G + G SG A++P+A+ Sbjct: 196 TDIVAVATACVAAGADGLSLINTLLG---LVIDTETLRPALSGVT--GGLSGPAIRPVAV 250 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + Q+ D PI G+GGI + DA +FLL GA + V T I + + Sbjct: 251 RCVWQVHAAL--PDVPIIGMGGIRSGLDALQFLLAGACAVSVGTEIF-HDPSAPARIRDE 307 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 L+ LA +GF + +++GLA+ Sbjct: 308 LAEALAARGFQRVSDVIGLAHR 329 >UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 Tax=Planctomycetaceae RepID=D2QWH7_9PLAN Length = 315 Score = 195 bits (495), Expect = 3e-48, Method: Composition-based stats. Identities = 87/314 (27%), Positives = 144/314 (45%), Gaps = 21/314 (6%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDH 63 DLS+T ++ NP +S G EM + + GG++ KT+ +P Sbjct: 11 VDLSVTLGRLRLRNPILTASGTFGYAREMESLVDFSKLGGILPKTVTQQPRAGNTP--WR 68 Query: 64 LVKEDTGFIGFKNMEQIAEH-PLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 V+ G + ++ + ++ L L +I SI G N ++ +A Sbjct: 69 TVETTAGLLNAIGLDNDGIETFIAHHMPYLGSLPTS-----IIVSIAGSNHNEFVAMAGR 123 Query: 123 VQEA-GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + + G IE N SCP + G D G L EK + + P+LAK+TPN+ Sbjct: 124 LSDIDGIAAIELNISCPNVAH---GIDFGADASLCEKLVSDCVKATRHPILAKLTPNVTR 180 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + +VA A GGAD ++ INTV+ + ++ + P++ + + G SG A+KPIALR Sbjct: 181 IADVAKGAANGGADALSLINTVQGMA---IDWRKQKPLLG--NVMGGLSGPAIKPIALRC 235 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q+R I GI T +D EF++ GA+ +Q+ T Y + +A+ L Sbjct: 236 VHQVRQAVSTPIIGIGGI---ATIDDVMEFIVAGASAVQIGTAN-YYDPTVTMKLAAALP 291 Query: 302 HYLADQGFDSLQEM 315 L + G S+ E+ Sbjct: 292 FALQEIGAKSIAEV 305 >UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydroorotate oxidase n=1 Tax=Streptococcus mutans NN2025 RepID=C6SRR7_STRMN Length = 330 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 67/323 (20%), Positives = 121/323 (37%), Gaps = 14/323 (4%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPR 60 T F N ++ E A + G V KT PR Sbjct: 19 SMVSTHTTIGSFDFDNCLMNAAGVYCMTREELAAIDHSEAGSFVTKTGTLEERAGNPQPR 78 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 + +G N+ + L + L++ K S++G + ++ + Sbjct: 79 YADTKLGSINSMGLPNL------GINYYLDYVTELQKQPDSKNHFLSLVGMSPEETHTIL 132 Query: 121 RLVQEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 ++V+ + + E N SCP + + E ++ V T P+ K+ P Sbjct: 133 KMVEASKYQGLVELNLSCPNVPGKP---QIAYDFETTDQILSEVFTYFTKPLGIKLPPYF 189 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ AA + +N + SI N L + ++ K+ G G VKP AL Sbjct: 190 -DIVHFDQAAAIFNKYPLTFVNCINSIGN-GLVIEDETVVIKPKNGFGGIGGDYVKPTAL 247 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 + I G GG++T DA E +L GA+ +Q+ T + Q G +I + + Sbjct: 248 ANVHAFYKRL-NPSIQIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPQIFKRITKE 306 Query: 300 LSHYLADQGFDSLQEMVGLANNN 322 L + ++G+++L++ G N Sbjct: 307 LKAIMTEKGYETLEDFRGKLNAM 329 >UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacteria RepID=B7K1Y7_CYAP8 Length = 339 Score = 194 bits (494), Expect = 4e-48, Method: Composition-based stats. Identities = 66/330 (20%), Positives = 125/330 (37%), Gaps = 20/330 (6%) Query: 16 PNPFCLSSS-PVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV----KEDTG 70 +P + S P+ + + D G VV + + H + + Sbjct: 13 KSPLVVGSCAPLTEDIDNLKRMEDAGAAAVVLHSFFEEQLRQERLELHHHLTYGTESFAE 72 Query: 71 FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADM 130 + + +I +E L +R+ KE D +I S+ G W + A+ +Q+AGAD Sbjct: 73 ALTYFPEPEIFHIGSQEYLNHIRQAKEMV-DIPIIGSLNGSTLGGWLDYAQQIQQAGADA 131 Query: 131 IECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAK 190 +E N G +V Q+ + VK +P+ K++P +M +A Sbjct: 132 LELNIYYVPTDLDIPGGEVEQNY---LDILKNVKAALNIPVAIKISPYFSNMANMAKRLA 188 Query: 191 RGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPE 250 GADGI N +IDL P V S + +R+I + E Sbjct: 189 EAGADGIVLFNRFYQ-PDIDLENLEVYPNVL-------LSTPQALRLPMRWIAILYGRIE 240 Query: 251 LRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFD 310 ++ GI D + +++GA QV + ++++G + + G+ ++ D ++ Sbjct: 241 A---DLAATSGIHHTTDVLKMVMVGAKITQVVSALLRHGIGYLSTLEQGMIRWMEDNEYE 297 Query: 311 SLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 S+++M G + P + Sbjct: 298 SIKQMQGSLSQLHCPDPTAFERAQYMKALQ 327 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 194 bits (493), Expect = 5e-48, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 135/322 (41%), Gaps = 20/322 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 +++ G++ NP ++ G ++ + G + K + +PR Sbjct: 4 QVKMAVNLGGIQMKNPINTAAGTFGYGWQFEGFYDVSLLGAITMKGVARVPWEGNPAPRM 63 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L +G N + + ++ L++ +I + + Q+ ++ Sbjct: 64 CELNGGMMNSVGLANPGV--DDFIAHTDDYMKDLEDR--GTRVIMQMAAHSVQEMIDVVE 119 Query: 122 LVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 ++E IE N SCP + G +G +PE + +AV+ + LP+L KM P Sbjct: 120 RLEELNPHISAIELNVSCPNLEKG--GRPLGGTPEQATEIMKAVRPLTKLPILVKMAP-- 175 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 ++ E+ A + GADG+ IN++ ++ I+++ + G SG A+ Sbjct: 176 VNVAEIGKAFEAEGADGLTLINSIPGMS-INVHTRKSRLSKP----TGGLSGPLCHNAAV 230 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + + PI G+GG+ET EDAAEF+L GA + V + + Y + + Sbjct: 231 RMVWECAQAV---SIPICGVGGVETGEDAAEFILAGATAVSVGSANL-YDPMCAPRILNE 286 Query: 300 LSHYLADQGFDSLQEMVGLANN 321 L+ + QG + E++G Sbjct: 287 LTDWAKSQGVSDIHELIGAVEC 308 >UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic subunit n=1 Tax=Oceanicola batsensis HTCC2597 RepID=A3U0T3_9RHOB Length = 314 Score = 194 bits (493), Expect = 5e-48, Method: Composition-based stats. Identities = 85/313 (27%), Positives = 140/313 (44%), Gaps = 21/313 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIANEVSPRF 61 DLS+T GV+ NP +S + E A D G G +V KTI + V P Sbjct: 1 MVDLSVTVGGVRMKNPVMPASG---SIAEGMADVVDLGRLGAIVLKTITPDLRQGVKPP- 56 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 +V+ + I + L + + +IASI + + + +LA Sbjct: 57 -RVVEYTDATLFSIG---IPSKGPDYLLNHTVPFFDKF-GPPVIASISADTVEDFGKLAG 111 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 + + IE N SCP + +H G G P + A+K +TLP+ AK+TPN+GD Sbjct: 112 YITDPRIAAIEANISCPNLRAH--GRAFGMDPVASAQVITAMKANTTLPIWAKLTPNVGD 169 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + E+A + GAD + N + + ++ + P + + + G +G AVKP+ LR Sbjct: 170 IAEMARCVEGAGADAVITANAILGMA---IDAETMTPRLG--NVVGGLTGPAVKPVILRM 224 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + Q E P+ G GGI T ED E++L GA+ +Q+ T + +E ++ Sbjct: 225 VNQCA---EAVKIPVIGCGGIATGEDVVEYMLAGASAVQIGTTNFVH-TSAMEQSIDWVA 280 Query: 302 HYLADQGFDSLQE 314 Y +G + + Sbjct: 281 DYCTRKGIARVSD 293 >UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellular organisms RepID=Q2H299_CHAGB Length = 596 Score = 194 bits (492), Expect = 6e-48, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 97/324 (29%), Gaps = 29/324 (8%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L++T G NP +S+ E+ + G G V PR + Sbjct: 268 LAVTVFGTTLANPIGISAGLDK-DAEIADPLFALGAGVVEVGGCTPLPQAGNPRPRVFRV 326 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 D G + + + L LR+ GE E + + Sbjct: 327 PAVD-GLVNRYGLNSRGADAMAARLRERLRKFARGLGLSEREVLEAGEEEGGCADGESVA 385 Query: 124 QEA-----GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP---MLAKM 175 EA AD++ N S P L+ KR ++ K+ Sbjct: 386 GEAARLAPYADVLVVNVSSPNTPGLRDLQAAEPLARLLGAVVDEAKRAKRKVKPRVMVKV 445 Query: 176 TPNIGDMCEV---ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK-SSISGYSG 231 +P+ D ++ A G DG+ NT K T + G+SG Sbjct: 446 SPDEDDDTQMDGVVQAVWMSGVDGVIVGNTTKRRTGLVKEGIKLTGREQKALVEDGGFSG 505 Query: 232 KAVKPIALRFIQQMRTHPELRDF-------------PISGIGGIETWEDAAEFLLLGAAT 278 A+ L + + R + I GGI + A + L GA+ Sbjct: 506 PAMFDRTLSLVGRYRKMLDSYSLKTSGVNDVFPTPKVIFATGGITNGDQALQVLNAGASV 565 Query: 279 LQVTTGIMQYGYRIVEDMASGLSH 302 V TG++ G + + + Sbjct: 566 AMVYTGMVYGGSGTITRIKKEMRE 589 >UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E0W2_METI4 Length = 344 Score = 194 bits (492), Expect = 7e-48, Method: Composition-based stats. Identities = 68/340 (20%), Positives = 140/340 (41%), Gaps = 19/340 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 ++ L T+ G+K +P S+SP+ + + G G VV ++ + + Sbjct: 1 MSTSLETTYLGLKLSSPLVPSASPLSKSIDTVKALEEMGAGAVVLYSLFEEDIEKEALHL 60 Query: 62 DHLV----KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 + V + + + + + L LRRLKE +IAS+ ++ QW Sbjct: 61 ERSVTMGTESFAEALSYVPEVPGLKMGPDYYLDHLRRLKESVS-IPIIASLNAQSPGQWV 119 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 + A+L++EAGAD +E N +++ Q + A ++ +LP+ K++P Sbjct: 120 KYAKLIEEAGADALELNLYSIPTQESLSSTELEQ---RYLEIVSACRQSVSLPIAVKLSP 176 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + ++ G+ N +IDL P + S + + Sbjct: 177 FFTNFFSFSSRVEKTAVQGLVLFNRFFQ-PDIDLENMTVEPRIT-------LSTEGELLL 228 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 + +I + + +S GGI + D + LL GA T+Q+ + ++ +G ++ + Sbjct: 229 RITWIGILYNRVK---LDLSATGGILSSTDVLKALLSGATTVQLCSALLYHGVEYLKTVK 285 Query: 298 SGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYP 337 +G+ +L ++G+ S+ E+ GL + P Sbjct: 286 NGVVEWLEEKGYRSINEIRGLLSQKNCPDPSSYERAQYVY 325 >UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W1V7_9ACTO Length = 341 Score = 193 bits (491), Expect = 9e-48, Method: Composition-based stats. Identities = 61/312 (19%), Positives = 107/312 (34%), Gaps = 41/312 (13%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVKE 67 +F + L++ N E G+G + TI PR L + Sbjct: 55 SFLPKRVQGRLGLAAGMDKN-AEAIHAFSALGFGFIEIGTITPKGQPGNPQPRLWRLPET 113 Query: 68 D--TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDK-VLIASIMGENE--------QQW 116 +GF N H ++ L L +L+ + +++ S +G+N+ + Sbjct: 114 REIRNQMGFNN------HGVDAALLKLTKLRSTEAGRKIVVGSNIGKNKITSNDEALNDY 167 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS--TLPMLAK 174 E A + +D + N S P V +VE + + + + K Sbjct: 168 EICASTLAPL-SDFLVINVSSPNTPGLRDLQTVESLRPIVETTQESANNAAQRDVSVFIK 226 Query: 175 MTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D+ VA G G+ A NT + G SG Sbjct: 227 IAPDLADEDILAVADLVNETGLTGVVAANTT----------------IKHSYESGGISGP 270 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + L + +R + D I G+GGI T +DA +L GA L+ T + G Sbjct: 271 RLLNRGLDIVANLRKELDY-DKTIIGVGGISTPDDAISYLDAGADLLEALTAFIYEGPAF 329 Query: 293 VEDMASGLSHYL 304 + + +Y Sbjct: 330 PGRINRAVKNYR 341 >UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=B7RZ94_9GAMM Length = 552 Score = 193 bits (490), Expect = 1e-47, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 132/299 (44%), Gaps = 21/299 (7%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDT--GWGGVVFKTIGFFIANEVSPR 60 + +LS G PF + S V + +D G V K+IG + Sbjct: 11 SSNLSTELFGKTLSGPFTIPSGIVTTAVPIIQYIFDHMPEVGVVTTKSIGPEPRDG---- 66 Query: 61 FDHLVKEDTGFIG-FKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 G F N + + + + +L+ D+ L+ SI G + ++ E+ Sbjct: 67 -YREPVLSQYAPGCFVNAVGLTNPGPQRSAELMAQLRVPE-DRFLLTSIFGGSIDEFVEV 124 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 A+++ +D +E N SCP + M +GQ P++V + AVK +P++ K+TPN Sbjct: 125 AKILAPV-SDGLELNLSCPHAKGYGM--AMGQDPDMVREIVAAVKAVVDIPVIPKLTPNT 181 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 D+ +A AA+ GGADG AINTV G P+++ + G SGK + PI L Sbjct: 182 PDITVIARAAEAGGADGFCAINTV----GPGYTSAHGHPVLS--NGAGGMSGKGILPIGL 235 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 + ++++ E+ D PI G GG+ + +D F GA + V + + + Sbjct: 236 KCVKEVA---EVSDLPIIGCGGVSSADDVRAFFDAGAEIVGVGSALTGMTTDEIGAYFK 291 >UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonproteobacteria RepID=PYRD_NAUPA Length = 359 Score = 193 bits (490), Expect = 1e-47, Method: Composition-based stats. Identities = 71/323 (21%), Positives = 123/323 (38%), Gaps = 42/323 (13%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L ++F NP +++ + M G+G + PR Sbjct: 51 LHQKIWDLEFKNPVGVAAGFDKH-ATMVYGWPALGFGWGEIGAVTPKPQPGNEKPRAWRH 109 Query: 65 VKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 ++ + GF N +RLK+ YP + I + +G+N+ EE R Sbjct: 110 IEYEAVQNAYGFNNEGVEVIK---------KRLKKIYPFILPIGANIGKNKTTPEE--RA 158 Query: 123 VQEAGADMIEC---------NFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 V++ + E N S P + E + +K + P+L Sbjct: 159 VEDYKILVNELKDVVDFFVVNVSSPNTPGLRDL----LNAEFISSLFGELKNLTDKPILI 214 Query: 174 KMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K +P++ D + +A + GADGI NT + +VN + G SG Sbjct: 215 KFSPDMEDELIINLANYSVLAGADGIIVTNTTVN-----------YDLVNSEIKRGGISG 263 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 K + + ++ + PI +GGI++ E+A + + GA+ LQV T I+ G Sbjct: 264 KPLAQRSYEVLRIVAGEV-FGKVPIISVGGIDSAEEAYKRIKAGASLLQVYTAIIYKGPG 322 Query: 292 IVEDMASGLSHYLADQGFDSLQE 314 IV ++ GL L G+ + E Sbjct: 323 IVGEINRGLIELLKKDGYSHISE 345 >UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PC95_9FIRM Length = 799 Score = 193 bits (490), Expect = 1e-47, Method: Composition-based stats. Identities = 105/430 (24%), Positives = 173/430 (40%), Gaps = 36/430 (8%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFK-TIGFFIANEVSPRFDH 63 + + GV F NPF ++S P + +TGW K +I PR+ Sbjct: 6 RIPVKVGGVTFKNPFYVASGPTTKNVRQLQRIEETGWAAASIKLSIDPAPYINRKPRYG- 64 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG---ENEQQWEELA 120 + ++T + F +++ +E L + K+ D +L+A+I W +A Sbjct: 65 -LFDETNALAFTAEKRLT---FQEGLTLIEDAKKVLSDLILMANITYAGDRGAAGWVNMA 120 Query: 121 RLVQEAGADMIECNFSCPQM-------------TSHAMGSDVGQSPELVEKYCRAVKRGS 167 + + GAD+IE N CP M TS G+ +G+ +V + RA+K+ Sbjct: 121 KQFEAVGADIIELNMCCPNMSYNVSLSSGGAASTSQQTGASLGRQAGVVAEIVRAIKKEI 180 Query: 168 TLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI-VNGKSSI 226 +P+ K+TP G++ +VA A GAD + + + IDLN + + S+ Sbjct: 181 HIPLFVKLTPEGGEVAQVAAALYAAGADAVGSTGNRLGLPPIDLNDPGRAVYHLQDEISM 240 Query: 227 SGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 S Y G +KP+A R ++R + + GGI W A E +L G L V + Sbjct: 241 SCYCGSWLKPLAQRDAYEIRKVCGMEPK-MMAAGGITDWRSAVEMVLCGGNLLGVCAETL 299 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVG 346 GY IV M GL Y+ G+ S+ + G + + A +L + Sbjct: 300 ISGYDIVRPMIRGLKDYMDTHGYRSIDDFCGKVVSAVRTAPELTLHDGYAHIREPNL--- 356 Query: 347 CGRCYISCYDGG-----HQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVKFK 401 G C +C Q++ + T K V C ++CP C E Sbjct: 357 AGPCKAACPHHVPVQAYVQSIARGDFHHAYELITGKGVLQGACAYICPHPC----EDACV 412 Query: 402 KGEKEHPVTL 411 +G PV + Sbjct: 413 RGRTGRPVAI 422 Score = 48.9 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 35/234 (14%), Positives = 67/234 (28%), Gaps = 31/234 (13%) Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + A A GA I T +K + G + ++GY A++ AL Sbjct: 581 AADGARCALHMGAAAAVVIPT-----GTMPEKKAALLRGEGITVLNGYKPAALEDGALIL 635 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 + L G + + + L G + + A L Sbjct: 636 SGPAGSRVSLP------CGSVWSAQSEEVRLAAGDGVFTAGGANIIAAAASGYNAAVRLD 689 Query: 302 HYLADQGFD----------SLQEMVGLANNNIVPAEDLDRSYIVYPRINLDKCVGCG--- 348 ++ + + ++++ A + + +C+ CG Sbjct: 690 QWVMGEKAVLKPSPRPVPVAAEQVLKRAGYVGDSPDAPVIASKEQAIAEAGRCLNCGCGE 749 Query: 349 ---RCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEVK 399 C C D + +CV C +C + CP IE+ +K Sbjct: 750 GCQLCKTICTDFA----PLVTGPDQLAIDRTQCVACGMCYNRCPNKNIEMLPIK 799 >UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=Streptomyces ambofaciens ATCC 23877 RepID=A0ADR6_STRAM Length = 297 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 125/300 (41%), Gaps = 22/300 (7%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 G++ +P + S + + + +D G VV KTI R L Sbjct: 6 RILGLRLSSPVVVGSGLLTDQERNIRRLFDDGASAVVTKTIHPDPGPAGEERLLRLPT-- 63 Query: 69 TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGA 128 G N + P+ + A LRR +D +IAS+ E+ + ELA LV +AG+ Sbjct: 64 ----GMLNSTTYSRRPVGDWCAMLRRFADD--GLPVIASVHAESPDELAELADLVGQAGS 117 Query: 129 DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALA 188 +E SC G + +PE V Y AV+R + +P K+ + E A Sbjct: 118 PALELGISCLN-----EGGGLDDTPERVAAYTDAVRRRTPVPFSVKLAAG-ERLRERVEA 171 Query: 189 AKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTH 248 A GAD I +TV + ++ G + G GYSG +KP+ L I +R Sbjct: 172 ALACGADAITLSDTV---AGLAVDADTGEVRLGGAF---GYSGAGIKPLVLAEIFGLRRA 225 Query: 249 PELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQG 308 P+ GG+E D AE+L +GA +QV T + + + + + G +L G Sbjct: 226 --GLTVPVMASGGVENGRDVAEYLSVGADAVQVYTALHREMHATLRAIRRGFDEWLGAHG 283 >UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family protein n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31DA9 Length = 303 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 118/321 (36%), Gaps = 25/321 (7%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAK----AYDTGWGGVVFKTIGFFIA-N 55 M L +FCG++ +P S A + V KT+ Sbjct: 1 MSAPSLPTSFCGIELAHPIVNGSGTFDAIAAQRAFGDALVEQFPFAAFVSKTVTVAPREG 60 Query: 56 EVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQ 115 PR L IG N L +L L RL LI ++MG ++ Sbjct: 61 NPPPRLWELPAGLINSIGLPNKGLAG--YLTHDLPELARLP-----VPLIVNVMGFTREE 113 Query: 116 WEELARL-VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAK 174 +L + +E N SCP + G+ +G P + V+ + P++ K Sbjct: 114 VAQLVTAFAERDEVAALELNVSCPNVE---TGTIMGSDPTETARLVERVRPLTQKPIVVK 170 Query: 175 MTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 +TPN D VA AA+ GADG++ INT++ + L+ + P + G SG V Sbjct: 171 LTPNASDPGAVAEAAEAAGADGLSLINTIRGMA---LDPRTREPWLGA--GTGGVSGATV 225 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 + +AL + + P+ +GG++ DA + L GA + V T Sbjct: 226 RAVALAQVSDVAQRV---SIPLIAMGGVQRGRDADDLLRAGATLVAVGTESF-RDPAAGR 281 Query: 295 DMASGLSHYLADQGFDSLQEM 315 +A L ++ Sbjct: 282 RVAHELERLRRERTSSGAPTR 302 >UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroides RepID=C3PUX9_9BACE Length = 324 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 132/338 (39%), Gaps = 17/338 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 L TF G+ NP +SSS + N E K G G +V K++ + Sbjct: 1 MTQLKTTFAGLSLRNPIIISSSSLTNSAEKNKKLELAGAGAIVLKSVFEEQ---IMMEAH 57 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 H+ + + H L E ++ + + K+ +IASI + +W + AR Sbjct: 58 HMATYGSPEGDDYLSTYVRSHALNEYISLIEQTKK-LCTIPVIASINCFSNSEWTDFART 116 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 V+ AGAD +E N Q G + ++K+ ++P++ K+ N+ + Sbjct: 117 VETAGADALEINILSLQTEKEY---QCGSFEQRHIDIVSSIKKQISIPVIVKLGSNLTNP 173 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + GA+ + N +I+++ S+ +S A LR+ Sbjct: 174 IALINQLYANGANAVVLFNRFYQ-PDINIDTMTY-------SAGDVFSTPADLSNGLRWT 225 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 D+ I GG+ + + +L GA+ +++ + I Q G +++ DM + ++ Sbjct: 226 AIASAQVPQTDYAI--SGGVHDGKAIVKAILAGASAVELCSVIYQRGNQVIADMTNEITQ 283 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 ++ QG+ ++ E N A + + Sbjct: 284 WMNRQGYKNISEFKSSMNALSTGASNPFERTQFMKYFS 321 >UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 Tax=Bacteria RepID=A6L9F5_PARD8 Length = 325 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 65/339 (19%), Positives = 126/339 (37%), Gaps = 16/339 (4%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 D+ + G+ NP + SS + N E G G +V K++ S Sbjct: 1 MIDIKTQYAGLTLRNPIIVGSSGLTNKAERNRDFEKAGAGAIVLKSLFEEQIEMQSEALM 60 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 + + + + + L +++ KE +IASI W + AR Sbjct: 61 QDSDYPEAADYIRG--YVKANQVNDYLELIKKSKE-LCTIPIIASINCYKADAWIDFARQ 117 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 ++ AGAD +E N + + D + R VK ++P++ K+ N ++ Sbjct: 118 IELAGADALELNVFFMETE---LTEDFESIRDTYVSIIRKVKETVSIPVIMKIGKNYSNI 174 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 + K GADG+ N +ID+N + + S +S +R+ Sbjct: 175 PSLVNLLKVNGADGVVLFNRFYQ-PDIDINNMQ----IVSGNVFSNHS---DLSDTIRWT 226 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + I+ G+ WED + LL GA+ +Q+ + + +G I+ + + + Sbjct: 227 AIVSGKIPG--ISIASSTGVHDWEDVVKCLLAGASAVQMCSAVYTHGAEIISQVLTCVEE 284 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINL 341 ++ + SL + G N +P + + Sbjct: 285 WMHQAHYQSLSQFQGKLNYANIPNPAMYERSQFMKYFSN 323 >UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacterium KB13 RepID=B6BWI2_9PROT Length = 335 Score = 192 bits (488), Expect = 2e-47, Method: Composition-based stats. Identities = 55/307 (17%), Positives = 112/307 (36%), Gaps = 34/307 (11%) Query: 10 FCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKED 68 G+ F N L++ N E + G+G + T+ PR K D Sbjct: 48 IKGLNFKNKVGLAAGFDKN-AEHMQIFENLGFGFLELGTVTPKPQSGNKKPRIFRDPKND 106 Query: 69 TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEELARLV 123 I + + +N+ + ++I +G+N + + Sbjct: 107 A-LINSFGFNNVGIYKFIDNIKKSK-------INLVIGINIGKNALTPYEDSINDYIACM 158 Query: 124 QEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-----TLPMLAKMT 176 +EA AD + N S P + ++ ++ + ++P+ K++ Sbjct: 159 REAYVYADYLTVNISSPNTKNLRDLHNLSDLSIFIKSLMIEKNKLQKKLKKSVPIFLKLS 218 Query: 177 PNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAV 234 P+I + + DG+ NT + I P + G SG + Sbjct: 219 PDIEKSKIKPIIDLLIANNIDGVIVTNTTIDKSKI------SKPYQHL---PGGVSGAPL 269 Query: 235 KPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVE 294 K + + + ++ + + I +GGI T +DA + + +GA +Q+ TG++ G +V Sbjct: 270 KIKSEQMLSTVKKISKNK-LLIISVGGIMTADDALKRIRMGADLVQIYTGLIYQGPSLVN 328 Query: 295 DMASGLS 301 ++ LS Sbjct: 329 EIRQKLS 335 >UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family protein n=1 Tax=uncultured actinobacterium RepID=D0U5Z4_9ACTN Length = 324 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 24/325 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGF-FIANEVSPRFDH 63 D S+ V+F +P L+S G+ E+ + G +V K++ A +PR Sbjct: 8 DHSVRVDDVEFKSPVLLASGTAGHADELEPYFPLSKIGAIVVKSMSSFEWAGNKAPRLRP 67 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 +G + + H +E +L L+++K ++ASI G + + A L+ Sbjct: 68 TNGGMLNAVGLQGLGV--AHWIEHDLPRLKKVKAT-----IVASIWGFSIDDYRSAASLL 120 Query: 124 QEAGAD--MIECNFSCPQMTSHAMGSD-----VGQSPELVEKYCRAVKRGSTLPMLAKMT 176 E D IE N SCP + S + ++ +L + R V + +P+ AK++ Sbjct: 121 SEVSTDLAAIEINLSCPNIGSSSKAANTPHGIFAHDEDLSAEIVR-VCSVAKVPLWAKLS 179 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 PN + +VA A + G + INT + ID+ + G + P Sbjct: 180 PNTDRVVDVAAAVSKAGCQAVTLINTALGLA-IDVETGLPALGNGGGGLSG----SGIHP 234 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 IA+R I +R L PI G+GGI EDA E ++ GA+ +QV T R + Sbjct: 235 IAVRTIFDVR--TRLPRLPIIGVGGIANGEDAIEMMMAGASCIQVGTATFA-DPRAAMRI 291 Query: 297 ASGLSHYLADQGFDSLQEMVGLANN 321 + + G ++ E+V A+ Sbjct: 292 DREMRQWARKHGVNNWSEVVNAAHK 316 >UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold_58 n=1 Tax=Sordaria macrospora RepID=D1ZM19_SORMA Length = 753 Score = 192 bits (487), Expect = 3e-47, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 112/350 (32%), Gaps = 57/350 (16%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 LS+ G + NP +S+ E+ + G G V F PR + Sbjct: 401 LSVNVFGKQLLNPIGISAGLDK-DAEIPDPLFALGAGVVEVGGCTPFPQEGNPKPRVFRI 459 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAA-LRRLKED----------------------YPD 101 D G I + + L LR+ +P Sbjct: 460 PTVD-GLINRYGLNSRGADAMATRLRERLRKFARSVGLSENQVLNEEGTDDIPPGSLHPG 518 Query: 102 KVLIASIMGENEQQWEELARLVQEA---------GADMIECNFSCPQMTSHAMGSDVGQS 152 ++L I + +++ ++++ AD++ N S P Sbjct: 519 RLLCVQIAKNKKTDEKDVNSVIRDYVYCVDKLAPYADVLVVNVSSPNTPGLRDLQATEPL 578 Query: 153 PELVEKYCRAVK--RGSTLP-MLAKMTPNIGD---MCEVALAAKRGGADGIAAINTVKSI 206 +L+ A + + P ++ K++P+ D M V A G DG+ NT K Sbjct: 579 TKLLSAVVDAAQATKRKNKPRVMVKVSPDEDDNTQMEGVVEAVWNSGVDGVIVGNTTKRR 638 Query: 207 TNI---DLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDF--------- 254 T I + P V G+SG A+ + + + R + Sbjct: 639 TGIIPQGVKLIGDEPEVLH--EEGGFSGPALFDRTVSLVGRYRKMLDGYALKNEADKSAA 696 Query: 255 --PISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + GGI E A + L GA+ V TG++ G + + + + Sbjct: 697 QKVLFATGGITNGEQALKVLNAGASVAMVYTGMVYGGSGTITRIKTEMKE 746 >UniRef50_A7H8H3 Dihydroorotate dehydrogenase n=4 Tax=Anaeromyxobacter RepID=A7H8H3_ANADF Length = 328 Score = 191 bits (486), Expect = 3e-47, Method: Composition-based stats. Identities = 63/341 (18%), Positives = 129/341 (37%), Gaps = 22/341 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANE----VS 58 +L + G+ P+P L+S + N E A G G VV +++ + Sbjct: 1 MAELVTEYMGLALPSPLVLASCALSNRVENLEMAEGHGAGAVVLRSLFEEQLEGAASALE 60 Query: 59 PRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + + + +++ H + L+ + R K + +IAS+ W + Sbjct: 61 EELLRGAESNPEARTYFPPQRVGPH---DYLSLVERAKRAL-EIPVIASLNCAAPGSWTD 116 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 AR +++AGAD +E N + G++V + AV++ +P+ K++P Sbjct: 117 YARDIEQAGADALEVNLYSVEADPTVSGAEVE---ARYLEVVAAVRQAVRIPIAVKLSPF 173 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + A G +G+ N +I L + +P + S + + Sbjct: 174 FSSLAHFATRLDGLGVNGLVLFNRFLQ-PDISLERMAALPTMTP-------SAPSEALVP 225 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 LR+I + ++ G+ + +L GA +Q+ + +M+ G + + + Sbjct: 226 LRWIALLHGRVRAH---LAASTGVYDAPGVLKQVLAGAQVVQLASTLMKNGIPHLGKVLA 282 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRI 339 G+ +L +G SL E+ G + V I Sbjct: 283 GIEDWLDRRGVSSLDELRGALSQREVSDPGAFERAQYVHLI 323 >UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondrial n=4 Tax=Plasmodium RepID=PYRD_PLAF7 Length = 569 Score = 190 bits (483), Expect = 7e-47, Method: Composition-based stats. Identities = 68/371 (18%), Positives = 126/371 (33%), Gaps = 72/371 (19%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVK 66 + F NPF +++ N G+ + TI PR V+ Sbjct: 210 TNIKHLDFINPFGVAAGFDKNGV-CIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVE 268 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKED---YPDKVLIASIMGENEQQW---EELA 120 + I + + ENL R+ +E+ ++ SI G+N+ ++L Sbjct: 269 SRS-IINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVSI-GKNKDTVNIVDDLK 326 Query: 121 RLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS----------- 167 + + G AD I N S P + G+ ++ + Sbjct: 327 YCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDESTY 386 Query: 168 -----------------------------------TLP-MLAKMTPNI--GDMCEVALAA 189 P + K+ P++ E+A Sbjct: 387 NEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVL 446 Query: 190 KRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHP 249 DG+ NT I +I + ++ G SG +K I+ +FI +M + Sbjct: 447 LETNIDGMIISNTTTQINDIK----------SFENKKGGVSGAKLKDISTKFICEMYNYT 496 Query: 250 ELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGF 309 + PI GGI + DA E + GA+ Q+ + ++ G + + L+H L +G+ Sbjct: 497 NKQ-IPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQIKRELNHLLYQRGY 555 Query: 310 DSLQEMVGLAN 320 +L+E +G + Sbjct: 556 YNLKEAIGRKH 566 >UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae RepID=C9M6H2_9BACT Length = 317 Score = 190 bits (483), Expect = 8e-47, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 132/329 (40%), Gaps = 21/329 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L+ G+ +P ++S E A Y G V K I R Sbjct: 7 LTCHVGGLDLTSPLVIASGIWPYEKEYWAGEYLDFAGAVCSKAITADPRPGNPGTRVWET 66 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 IG +N + L LR K L+ ++ E+ E + ++ Sbjct: 67 PCGMLNSIGLQNEGAGS--FFGGTLGRLRSY-----GKPLLLNVSMESSSDLERILDAME 119 Query: 125 EAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDM 182 D +E N SCP + M G P L + + V+R + P+ K+TP D Sbjct: 120 PVAPSVDCVELNVSCPNVDQGCM--SWGVDPALTAQAVQQVRRRWSGPLWVKLTPQAPDP 177 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 C VA AA+ GA + NT + + V G SG A+ P+ALR + Sbjct: 178 CAVAKAAQDAGASALVVANTWLGAAIDTVKARPAFDRVVA-----GLSGPAIFPLALRMV 232 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 Q+ D P+ G GG+ + + A L+ GAA ++V + + ++E +A GL Sbjct: 233 WQV---CGAVDIPVVGCGGVASADSAVAMLMAGAAAVEVGMALFS-DFSVLERIARGLEE 288 Query: 303 YLADQGFDSLQEMVGLANNNIVPAEDLDR 331 ++ +GF S+ E+VGLA + E + R Sbjct: 289 EVSRRGFQSVGELVGLARPDRDLQERMRR 317 >UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (class) RepID=B9L4A8_THERP Length = 374 Score = 190 bits (482), Expect = 8e-47, Method: Composition-based stats. Identities = 66/333 (19%), Positives = 124/333 (37%), Gaps = 39/333 (11%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 + L + + FPNP L++ N E A + G+G V T+ PR Sbjct: 63 ERLRVEVGDLTFPNPIGLAAGVDKN-AEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLW 121 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQ 115 +++T +GF + A RL + + ++ G+N Q Sbjct: 122 RFPEDETLVNALGFPSDGVAAVRA---------RLVGRWFPGPVGINL-GKNAWTPLEQA 171 Query: 116 WEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKY------CRAVKRGS 167 + + AD + N S P + +++ A++R Sbjct: 172 VVDYCATLVALWDVADYVVVNVSSPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRAR 231 Query: 168 TLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 P+ K++ ++ + + A GADG+ NT +ID + + + Sbjct: 232 PRPLFVKVSLDLDAGALADAIEIAVAVGADGLILGNT-----SIDPSLRPA----GAGAL 282 Query: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G SG+ ++ A+ + + +GG+ +D + L LGA +QV TG+ Sbjct: 283 PGGVSGRPLRKRAVELLSNAADRAG-GRLALISVGGVLETDDVIQRLRLGADLVQVYTGL 341 Query: 286 MQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 + G + + GL YL +QG S++ + G Sbjct: 342 VFRGPALPAVLLRGLLRYLDEQGLPSVRALRGR 374 >UniRef50_A8RT96 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC BAA-613 RepID=A8RT96_9CLOT Length = 361 Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 88/374 (23%), Positives = 143/374 (38%), Gaps = 36/374 (9%) Query: 38 DTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAE-HPLEENLAALRRLK 96 + G G VV KTI A N E+ A+ L + K Sbjct: 6 EAGAGAVVTKTIRLGAAINPVHHM-----GTVNQDSLINCEKWADSDRLNWYENEIP--K 58 Query: 97 EDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELV 156 V+I S+ G ++ + + + V+ AGA MIE V + + + Sbjct: 59 TVAAGAVVIGSV-GHTLKEAQAIVKDVERAGAHMIEL---------------VSYTEDTL 102 Query: 157 EKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIG 216 K +P++ K++ N D A GA+GI AI+++ ID+ + Sbjct: 103 LPMLDYTKEHVDIPVICKLSGNWPDTAATARRCLEHGANGICAIDSIGPTLKIDIEK--A 160 Query: 217 MPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGA 276 P + +G A++PIA+R+ Q+ + GG+ +DA E+++ GA Sbjct: 161 APEMMSGDGFGWMTGAAMRPIAMRYNYQIAKENPQL-MNLYASGGVMKADDAIEYMMAGA 219 Query: 277 ATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVY 336 + V T + G VE M LS LA+ G+ S+QE+ A+ N E + + Sbjct: 220 MGVGVCTAGILKGVEYVEKMCYDLSKRLAELGYSSIQEVNRAAHPNFPSEEHISGLKFHF 279 Query: 337 PRINLD----KCVGCGRCYISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGC 392 D KCV C +C C + + +KC C LC VCP G Sbjct: 280 TPFKEDGTTKKCVSCKKCETVCCYDARKLTFPEM-----TVDMDKCRCCGLCLDVCPTGA 334 Query: 393 IELGEVKFKKGEKE 406 + + + E Sbjct: 335 LTAELAPQTEKDLE 348 >UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=Q7N0H1_PHOLL Length = 289 Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 123/302 (40%), Gaps = 26/302 (8%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKED 68 G+K NP + S + + + + G G VV KTI PR + L E Sbjct: 11 DVLGMKIKNPIIVGSGLLSDQAKNIRQFIAHGAGAVVTKTI--------YPRSEKLHTEK 62 Query: 69 TGFI--GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 T G N ++ +E L LR KE+ +I SI E+ + LA + Sbjct: 63 TYLFSTGMLNNTTYSKKTVEYWLTLLREFKEEQ--LPVIVSIHAESPEALASLAVRISAV 120 Query: 127 GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVA 186 +E SC +PE V Y + VK + P K++ ++ Sbjct: 121 TDAPLELGISCLHADDFT-----EDTPERVFNYTKVVKERTNTPFAVKLSLG-DNLYGRV 174 Query: 187 LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 AA GGAD I +T+ I N + + + + GYSG +KP+ L I +R Sbjct: 175 QAAVEGGADAITLSDTISGIAFDTANGEALL------NGVCGYSGPGIKPMVLAAIYNLR 228 Query: 247 THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD 306 PI G GG++ D E+LL GA T+QV T + ++ Y+ ++ + + + Sbjct: 229 KR--GVTIPILGSGGVQDGNDVHEYLLAGANTVQVYTALHRHMYKTLQRIVHEYTQVMTS 286 Query: 307 QG 308 + Sbjct: 287 EK 288 >UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5YA20_COPPD Length = 274 Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats. Identities = 62/284 (21%), Positives = 109/284 (38%), Gaps = 24/284 (8%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVK 66 ++ + NPF SS G +G V KTI P LV+ Sbjct: 4 AVRLKKLTLKNPFIASSGTCGYADADLIPLDK--FGAAVTKTITLLPRQGNRPP--RLVE 59 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 G + ++ + ++ L ++ LI S+ GE+ + + + + Sbjct: 60 TPAGLVNSIGLQNMGLEAFKQFLTDFKK------PTTLIVSVGGESPEDFATIVEELNTY 113 Query: 127 G-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 D E N SCP + + G VG+ V A + +T P+L K++P + + Sbjct: 114 DLIDAFELNLSCPNVKTG--GEVVGKDYVTVSNILEASLKSTTKPLLVKLSP-FTEQLDK 170 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 L + NT ++ D++ + G P++ G SG A+ PI L I + Sbjct: 171 ILQHWESKVEAFVLFNTFPAM---DIDPRSGKPVLGA--VSGGLSGPAIYPIVLNSIYKY 225 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 + GGI T + A +F++ GA L++ TG + Sbjct: 226 SKAH-----TLVASGGIATTDIAKKFIMAGARALEIGTGNLWNP 264 >UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus ATCC 17982 RepID=A7BDH3_9ACTO Length = 312 Score = 188 bits (478), Expect = 3e-46, Method: Composition-based stats. Identities = 61/311 (19%), Positives = 106/311 (34%), Gaps = 40/311 (12%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKE 67 T + P+ L++ E G+ V T+ +PR L++E Sbjct: 26 TLGERRLPSRLGLAAGMDK-DAEAVLGMCALGYAFVEIGTVTPRPQPGNDAPRLWRLMEE 84 Query: 68 D--TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN--------EQQWE 117 +GF N E L LR ++ + +G+N +E Sbjct: 85 RGLRNRMGFNNA---GADAAAEKLRELR--STPAGRATIVGANIGKNKVTSEADAPADYE 139 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS---TLPMLAK 174 AR + D + N S P V +++ R + G+ T+P+ K Sbjct: 140 YCARTL-AHWVDFVVVNVSSPNTPGLRDLQSVDHLRPILQAARRGCEAGAPDRTMPLFVK 198 Query: 175 MTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGK 232 + P++ D+ V K G G+ A NT +N G SG Sbjct: 199 IAPDLADEDIVAVVELTKELGLAGVVATNTT----------------INHNLGEGGVSGA 242 Query: 233 AVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRI 292 + P AL + + H + + G GGI + EDA + GA ++ + + G Sbjct: 243 PLLPRALEVVSLVARHLDDDQI-LIGTGGISSPEDALRMISAGADLVEAFSAFIFEGPSW 301 Query: 293 VEDMASGLSHY 303 +++ L Sbjct: 302 PGEVSRALQRA 312 >UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Plasmodium vivax RepID=A5K1N1_PLAVI Length = 572 Score = 188 bits (478), Expect = 3e-46, Method: Composition-based stats. Identities = 66/370 (17%), Positives = 121/370 (32%), Gaps = 70/370 (18%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKE 67 G+ F NPF +++ N G+ + TI PR ++ Sbjct: 213 EIKGLNFINPFGVAAGFDKNGV-CIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLET 271 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPD--KVLIASIMGEN---EQQWEELARL 122 + I + + +NL R ++ + L+ +G+N ++L+ Sbjct: 272 RS-IINSCGFNNMGCDEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQDLSYC 330 Query: 123 VQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG-------------- 166 + + G AD I N S P + ++++ V + Sbjct: 331 IGKIGRYADYIAINVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGG 390 Query: 167 --------------------------------STLP-MLAKMTPNIGDMC--EVALAAKR 191 P + K+ P++ + +A Sbjct: 391 AAMGGATTGEAVVGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLN 450 Query: 192 GGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPEL 251 DG+ NT NI + + G SG+ +K ++ I QM + Sbjct: 451 AEVDGMIICNTTTQKFNIK----------SFEDKKGGVSGEKLKGVSTHMISQMYNYT-N 499 Query: 252 RDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDS 311 PI GGI T EDA E + GA+ Q+ + ++ G + + L H L +G+ Sbjct: 500 GKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRELDHLLYQRGYYK 559 Query: 312 LQEMVGLANN 321 L + VG A+ Sbjct: 560 LGDAVGRAHR 569 >UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacteria RepID=PYRD_BUCAI Length = 337 Score = 188 bits (478), Expect = 3e-46, Method: Composition-based stats. Identities = 54/312 (17%), Positives = 111/312 (35%), Gaps = 39/312 (12%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLV 65 I G+ F N ++ N E G+G + T+ PR +V Sbjct: 47 KIKCMGLIFDNKLGTAAGIDKNG-EYIDALSKLGFGFIEVGTVTPLPQVGNPKPRMFRIV 105 Query: 66 --KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE--------QQ 115 + +GF N+ + L R + K +I +G+N+ Sbjct: 106 SMEGIINRMGFNNLG----------IDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDD 155 Query: 116 WEELARLVQEAGADMIECNFSCPQMTSHAMGSD-----VGQSPELVEKYCRAVKRGSTLP 170 + + A I N S P T+ ++ K +P Sbjct: 156 YLICIEKIY-CYAGYIAINISSPNTTNLRNLQYGILFKKLLYKIKKKQKELHKKYLKYVP 214 Query: 171 MLAKMTPNIG--DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISG 228 + K++P++ ++ +++ R D + A NT + + S G Sbjct: 215 IAIKISPDLSIKELVDISKQLIRYKIDAVIATNTTLD--------HSSLFGLKNSSEQGG 266 Query: 229 YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQY 288 SG ++ + I + + + PI G+GGI + A E + GA +Q+ +G++ + Sbjct: 267 LSGLPLQKKSTNTISILSKSLQ-KKIPIIGVGGINSINSAKEKIESGATLIQIYSGLVYH 325 Query: 289 GYRIVEDMASGL 300 G ++++ + + + Sbjct: 326 GPKLIKKIINHI 337 >UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella benthica KT99 RepID=A9D5Y9_9GAMM Length = 334 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 122/312 (39%), Gaps = 12/312 (3%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFD 62 K +S V + +S P + + ++ K+ PR+ Sbjct: 22 KRISTRIAQVPLASFIFNASGPRCTEEDELNLLGASASAAIMTKSCTLEPRQGNAEPRYQ 81 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 L +G N+ E L L++ +K ++ S+ G + + + Sbjct: 82 ALPLGSIQSMGLPNL---GYQAYLEMLPRLKQAISPQTNKPIVVSVSGFSLADNLTMVKA 138 Query: 123 VQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP--NIG 180 Q + AD+IE NFSCP + VG E E+ + + + P+ K+ P + Sbjct: 139 FQASCADLIEVNFSCPNIEGKP---QVGYDFEQTERALEQLCQLGSKPIGLKLPPYFDFS 195 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 +A K+ I IN+V + ID + I+ K G G +KPI L Sbjct: 196 HFITMANIIKKFPVRFITCINSVGNTLVIDPETESA--IIKPKGGFGGLCGDYIKPIGLA 253 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 ++ I G+GGI+T DA E+LL GA+ +QV T + G + +A L Sbjct: 254 NVRAFSQLLPS-SIDIIGVGGIKTGTDAFEYLLAGASAVQVATCFEKEGIECFDRIAKEL 312 Query: 301 SHYLADQGFDSL 312 +A + + S+ Sbjct: 313 DSIMAAKQYSSI 324 >UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MPX3_BDEBA Length = 327 Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 104/302 (34%), Gaps = 28/302 (9%) Query: 12 GVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGF 71 G++F NP ++ N E + + G G V TI +P ++ D Sbjct: 41 GLEFANPMGIAGGVDKN-AEHLKEWWALGCGFVEVGTITPRAQ---TPNPGKIMDRDLEL 96 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENE-----QQWEELARLVQEA 126 N +E L +Y + +I G+N + LV + Sbjct: 97 QAMWNKMGFPSDGGDEVFHNLASYAPNYR-TPIFVNI-GKNRHTPNNDAVADYLTLVDQF 154 Query: 127 G--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--M 182 AD N S P L+ V P+L K++P++G+ + Sbjct: 155 RPFADAFVVNISSPNTAGLRDLQKKENLRALIGPIVDRVSHFEPTPVLVKLSPDMGEEGL 214 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 E + G DG NT S P + G SG +K ++ R + Sbjct: 215 AEAVSNCQELGVDGFVLTNTTLSR-----------PAGCHFPAEGGLSGAPLKQLSQRAL 263 Query: 243 QQMRTHPELRD--FPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 Q + + +GGI + ED E L +GA +Q+ + ++ +G D+A Sbjct: 264 QIAVQTLGKKREGLLLVSVGGIMSPEDVFERLQMGADLVQIYSALVFHGPGFFHDVARRY 323 Query: 301 SH 302 + Sbjct: 324 ND 325 >UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=candidate division TM7 RepID=UPI00016B255A Length = 394 Score = 187 bits (476), Expect = 5e-46, Method: Composition-based stats. Identities = 72/323 (22%), Positives = 124/323 (38%), Gaps = 25/323 (7%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 L CG+ F NP LS+ N E+ G+G + +I P F Sbjct: 72 RLKQNICGINFSNPVGLSAGFDKN-IELIPTMSMVGFGYMTGGSITITPRAGNPRPWFYR 130 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAAL--RRLKEDYPDKVLIASIMGENEQQWEELAR 121 L K + + + + + +N+ + P + IA + + ++ + Sbjct: 131 LPKSKSIVVHA-GLANDGANIILQNIKRQYKKEANRKIPLFISIAVVARSQDSTEADIIK 189 Query: 122 LVQEA--------GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLA 173 V EA A +E N SCP + + + + L+ + K + +P+ Sbjct: 190 DVCEAMSLVSGSGLAKAVEINISCPNIDDNQPFTYPDKLDNLLSQL---DKINADMPIFI 246 Query: 174 KMT--PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 KM + + + +G+ N VK +NI+L K+ + G SG Sbjct: 247 KMPNLVDFVRFGLILEIISKHKINGVTISNLVKDRSNINLKDKLPESV------KGGLSG 300 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 K + +L I+ I G+GGI EDA + G++ + + TG+M G + Sbjct: 301 KPCRDRSLDLIKFTYEKYGD-RLLIIGVGGIFNAEDAYLKIRAGSSLVALITGLMFEGPQ 359 Query: 292 IVEDMASGLSHYLADQGFDSLQE 314 +V D+ GL L GF SL E Sbjct: 360 MVGDINHGLDKLLKRDGFSSLTE 382 >UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyrus kandleri RepID=Q8TXU6_METKA Length = 318 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 76/314 (24%), Positives = 127/314 (40%), Gaps = 14/314 (4%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKE 67 + G ++ +P +S + A G + KT+ + Sbjct: 4 VEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDYLD 63 Query: 68 DTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 + + + + + R D D + AS+ + + ++ LAR Sbjct: 64 EGYALNAMGLPNPGPDRMVVEIEEFR----DEFDVPVYASVAADGPEGFKRLARAFSGV- 118 Query: 128 ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--MCEV 185 AD +E N SCP G+++G PE V + A R P+ K+TPN+ + EV Sbjct: 119 ADGLELNVSCPH-AGKGYGAELGSDPEAVAEITEAAVRAFDGPVSVKLTPNVDRETLLEV 177 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A AA GA+ + A+NT+ IDL + P++ + G SG A+KPIALR + + Sbjct: 178 AAAAIDAGAEALTAVNTLGPGLRIDL--RTASPVLGA--GVGGLSGPALKPIALRVVADL 233 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY-RIVEDMASGLSHYL 304 + I G+GGI ED EFL GA +QV T + + I + + L Sbjct: 234 ALEFGE-EVEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKELG 292 Query: 305 ADQGFDSLQEMVGL 318 D +++ + Sbjct: 293 YDGPEEAIGAALPE 306 >UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter pasteurianus RepID=C7JI08_ACEP3 Length = 336 Score = 186 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 125/342 (36%), Gaps = 20/342 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + D+ + G++ +P S+SP+ E + D G +V ++ Sbjct: 1 MAMDMRTNYLGLELAHPVVASASPLTADLEGILRVADAGASAIVMASVFEEDIQAQELAE 60 Query: 62 DHLVKEDTG----FIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWE 117 L + G+ + A PL+ LA LR E +IAS+ G W Sbjct: 61 AALWETGENSHPEAAGYFPVMHHAS-PLDGRLAVLRSAAERA-GVPIIASLNGCTPAGWL 118 Query: 118 ELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTP 177 A+ +++AGA IE NF G+ V E + R V+ +P+ K++P Sbjct: 119 RFAKDMEQAGAAAIELNFWHVPTNPDETGAQVE---ERCIQVLRDVRAQVKVPVSVKLSP 175 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + GA GI N+ L + + V S + Sbjct: 176 FFSSPGNMVKRLSENGAGGIVLFNSFYEPGLRSLTESAEVDFVP--------SSAYELRL 227 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 L + + H + ++ GG+ + D A+ LL GA V + ++Q G + + Sbjct: 228 PLMWAALLSEHCQA---DLAISGGVHSGMDVAKCLLAGADVAMVASVLLQKGPNYISTLL 284 Query: 298 SGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRI 339 + L +++ Q +++E G A+ D Y I Sbjct: 285 NELREWMSMQNLGAVKEFKGRMAARGTAAQAEDFLRTQYRHI 326 >UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VIM3_9BACT Length = 305 Score = 185 bits (470), Expect = 3e-45, Method: Composition-based stats. Identities = 73/305 (23%), Positives = 124/305 (40%), Gaps = 21/305 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L + +K +P ++S E G V KTI + PR Sbjct: 8 LQTSLGRLKVNSPVTVASGTFA--LENLDFIEQDHLGAYVCKTITRYPKKGNPPPRLYET 65 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 IG +N + + E+L LR LI S G + +++ ++ ++ Sbjct: 66 EAGLLNSIGLQNPGL--DKFIAEDLPVLRETLT----VPLIVSFSGSSLKEFVQMLECLE 119 Query: 125 -EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 + G E N SCP + + G G P++V K C + + ++ K++PN+ D+ Sbjct: 120 KQEGISGYEVNVSCPNVENE--GIAFGIDPDVVNKLCALLSPLTERELIVKLSPNVTDIA 177 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 +A AA+ GGA I+ INT+ + N K + G S +KP+AL Sbjct: 178 VIAKAAEEGGATAISLINTIWGMAIDYRNGKSRIKKGIGGYSG-----IGIKPLAL---A 229 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + P+ +GGI W+DA EF GA+ + + T V+ + GLS + Sbjct: 230 LTYRAAQAVKIPVIAMGGIYNWQDALEFFWAGASMIALGTANFI-DPLAVDKVYEGLSSF 288 Query: 304 LADQG 308 ++ Sbjct: 289 CLEKQ 293 >UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NF21_KYTSD Length = 385 Score = 184 bits (468), Expect = 4e-45, Method: Composition-based stats. Identities = 67/303 (22%), Positives = 111/303 (36%), Gaps = 37/303 (12%) Query: 11 CGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLVKEDT 69 GV F + L++ + + G G V T+ PR L Sbjct: 93 AGVAFGHRVGLAAGVDKDGTALLT-WQALGLGHVELGTVTPRPQHGNPRPRVHRLRASRA 151 Query: 70 --GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAG 127 +GF N +E + LR +++ + SI G+N+ LAR +++ Sbjct: 152 VLNAMGFPNA------GVEAAVHRLRVARDEGLTIPVGLSI-GKNKDTP--LARALEDYA 202 Query: 128 A---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS------TLPML 172 A D + N S P +D L+ A + + +P+L Sbjct: 203 ACVRVAAGLPDYLAVNISSPNTPGLRGLADPEPLRALLAGVVAAERERADAAGTPPVPVL 262 Query: 173 AKMTPNIGDMCEVAL--AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 K+ P++ D A A+ G GI A NT + + + G G S Sbjct: 263 CKVAPDMDDAALHAAVGIAQEEGVAGIIATNTTLRRDGLTAEDRAWV----GPERPGGVS 318 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 G + A ++ +R D P+ G+GG+ T +D E + GA +QV TG + G Sbjct: 319 GAPLTDRAREVVRLVRAGC---DLPVVGVGGVMTPQDGVELVRAGADLVQVYTGFIYAGP 375 Query: 291 RIV 293 +V Sbjct: 376 ALV 378 >UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UHA6_RHOBA Length = 359 Score = 184 bits (467), Expect = 5e-45, Method: Composition-based stats. Identities = 65/341 (19%), Positives = 135/341 (39%), Gaps = 25/341 (7%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + +L ++ G++ +P + + P+ E + G G +V +I Sbjct: 13 MPSELITSYLGMQLESPVVMGACPLTTQSEAVRQIVAAGAGAIVLPSILQEQV------M 66 Query: 62 DHLV--KEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQW 116 ++ + G I G++ + E L + RLK +IAS+ G + QW Sbjct: 67 HRMIKATDPFGAIERSGYQPQQDKYNGGTEAYLRTISRLK-GICSVPVIASMNGSSAGQW 125 Query: 117 EELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 + A+ ++ AGAD +E N S +D+ + R V+ +P+ AK++ Sbjct: 126 LQYAKEMESAGADALEFNLQQAVFDSKETSNDIE---ARMCDLIRQVRELVVIPVAAKIS 182 Query: 177 PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKP 236 ++ +A ++ G G+ + D++ +N + S + G ++ Sbjct: 183 QRYTNLSSMATQLRQVGVAGLVL---FTHMPQWDVSTDRMHWTINWELSPTNSIGGILEG 239 Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 I +R + I+ GG+ EDA + ++ GA + VT+ + + G + D+ Sbjct: 240 I-------VRARAGDQAISIAASGGVSNSEDAIKAMIAGADVVMVTSAVYRRGPDAIRDI 292 Query: 297 ASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYP 337 G+ ++ F +LQ+ + E R + P Sbjct: 293 VDGIERHVESSRFRTLQDFRAACPRDHAGDEKSVRLEYIDP 333 >UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flavoviridis RepID=B9UIZ1_9ACTO Length = 326 Score = 183 bits (465), Expect = 8e-45, Method: Composition-based stats. Identities = 72/306 (23%), Positives = 120/306 (39%), Gaps = 21/306 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 L + G+ NP + S + + + G G VV KTI + R Sbjct: 27 SQPMLEVPILGLSPANPVIVGSGLLTDQERNIRRLLGKGAGAVVTKTIHPSPPQGLDERI 86 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 L +G N ++ + L LR +D +IAS+ + + LA+ Sbjct: 87 LRLP------VGMLNSTTYSKRSVNRWLKTLRSFADDR--LPVIASLHADTPGELAMLAK 138 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 V+ G +E SC +P+ V Y V+ + LPM K+ Sbjct: 139 DVETTGCRALELGISCLNEEDGLE----DDNPDRVYAYTSEVRSKTALPMSVKLAVG-EG 193 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + + AA GGAD I +T+ ++ + + + GYSG +KP+ L Sbjct: 194 LRDRVRAAIAGGADAITLSDTIAGAAVSPTTGRLEL------NGVFGYSGPGLKPLVLAA 247 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLS 301 I Q+R P+ G GG+ + D A++L +GA+ QV T + YR +E + + Sbjct: 248 IWQLRKS--GIALPVMGCGGVSSGRDVADYLSVGASVAQVYTALHTDMYRTLERILAETR 305 Query: 302 HYLADQ 307 + Q Sbjct: 306 DLVGPQ 311 >UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacter pylori 51 RepID=D0IRU1_HELP1 Length = 330 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 99/284 (34%), Gaps = 42/284 (14%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L G+ FPNP L++ N M G+G + T+ PR Sbjct: 48 PKLENEILGLHFPNPLGLAAGFDKN-ISMLRALIAFGFGYLEAGTLTNAAQSGNERPRLF 106 Query: 63 HLVKEDT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELA 120 ++E++ +GF N + R P K I +G+N+ E A Sbjct: 107 RHIEEESLQNAMGFNNHGAVLGA---------RSFNRFAPYKTPIGINLGKNKH--IEQA 155 Query: 121 RLVQEAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPM 171 +++ A D N S P + Q+ V + K + P+ Sbjct: 156 HALEDYKAVLNKCLNIGDYYTFNLSSPNTPNLRD----LQNKAFVNELFCMAKEMTHKPL 211 Query: 172 LAKMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 K+ P++ DM EV +A GA GI A NT +V + G Sbjct: 212 FLKIAPDLEIDDMLEVVNSAIEAGAHGIIATNTTID-----------KSLVFAPKEMGGL 260 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLL 273 SGK + + +++ + + +GGI +DA E + Sbjct: 261 SGKCLTKKSREIFKELAKAFFNKSV-LVSVGGISDAKDAYERIK 303 >UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M0V6_ACIFD Length = 309 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 77/323 (23%), Positives = 122/323 (37%), Gaps = 21/323 (6%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRF 61 DLS+ + NP ++ G E+ A G V K++ +PR Sbjct: 1 MADLSVARGRLVLANPILTAAGCGGYGTELAAAVALERLGAHVVKSLTTVATEGNPAPRL 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + +G ++ LA D + S+ G + + E R Sbjct: 61 APVPGGMVNSVGLAGP------GIDRWLAETWPSLADAR-IPVALSVWGRQPRDYGETVR 113 Query: 122 LVQEAGAD--MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 IE N SCP + + P + AV+ P+L K++ N Sbjct: 114 RAARIAPSLVYIELNLSCPNLEADRAL--FAHDPNATARVVGAVRDEVATPILVKLSANT 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 + +VA AA GADG+ AINT+ + D + +G + G SG+AV+PIAL Sbjct: 172 DRIVDVAHAAVAAGADGLVAINTLFAQWYDDGREALGT------ARGGGLSGRAVQPIAL 225 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + +R PI G+GG+ T +D F+ GA +Q+ T + R + + Sbjct: 226 RAVADLRAAL--PTVPIIGVGGVATADDVERFVRAGADAVQIGTALFV-DPRRPVLVLAE 282 Query: 300 LSHYLADQGFDSLQEMVGLANNN 322 + LA G DS Sbjct: 283 IERRLARSGVDSWDRYARALRRQ 305 >UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding n=1 Tax=Treponema denticola RepID=Q73P17_TREDE Length = 591 Score = 181 bits (460), Expect = 3e-44, Method: Composition-based stats. Identities = 77/269 (28%), Positives = 120/269 (44%), Gaps = 15/269 (5%) Query: 23 SSPVGNCYEMCAKAYD-TGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIA 81 S + + D G+G V K+ R L + + G G N + Sbjct: 31 SGVLSTKPNLIRYCADELGFGLVTTKSFQVLP--NPGNREPILCEPELGCFG--NSVGLR 86 Query: 82 EHPLEENLAALRRLKEDYP-DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCPQM 140 +E+ + L+ L+ + D +L S+ N + + L + +E AD E NFSCP Sbjct: 87 NCGMEQAVKELKELRSSWKTDSILNVSLSASNPEDFISLLKGFEEL-ADCFELNFSCPH- 144 Query: 141 TSHAMGSDVGQSPELVEKYCRAVKRGST---LPMLAKMTPNIGDMCEVALAAKRGGADGI 197 S G+ +G P + +Y + +K+ +P+ K+TPN+ D+ +A A GADGI Sbjct: 145 ASAGFGASIGCDPAIAAEYVKIIKKALPDCAVPIFVKLTPNVEDIGAIASAVIEAGADGI 204 Query: 198 AAINTVKSITNIDLNQKIGMPIVNGK-SSISGYSGKAVKPIALRFIQQMRTHPELRDFPI 256 AINTV + + G PI+ K G SG V P AL I Q+R + PI Sbjct: 205 TAINTVG--PKVYIEPHSGKPILQNKLGGKGGMSGAWVFPRALECIGQIRKAVGE-EIPI 261 Query: 257 SGIGGIETWEDAAEFLLLGAATLQVTTGI 285 G+GG+ T AAE + GA + + + Sbjct: 262 IGMGGVMTGAQAAELVRAGADIIGIGSAC 290 >UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B240E Length = 338 Score = 176 bits (447), Expect = 1e-42, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 122/330 (36%), Gaps = 33/330 (10%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 K L GV F NP LS+ N ++ D G+G ++ + P F Sbjct: 7 KSLQQEIDGVNFRNPIGLSAGFDKN-VQLSPLMEDVGFGFASGGSVTLEPRKGNLRPWFH 65 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGEN---------E 113 L K + + + M + + A R + P V +A + ++ Sbjct: 66 RLPKTKSVVV-YAGMPNYGLEKIGNYVKANRIKIQSMPTVVSVAVVANKSTKDKLGPKVP 124 Query: 114 QQWE-----ELARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRG- 166 +++ + + + A ++E N SCP G + PE +E + + Sbjct: 125 EEYIVKDVKKAVNYIIDNKLASIVEINISCPN-----AGKESFIYPETLEILLKEIDTID 179 Query: 167 STLPMLAKMT--PNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 +P KM +I + + G+ N VK T +++ + I Sbjct: 180 RNIPFWIKMPHLYDINQFDSLLKVIVKHNIQGVTIANLVKDRTKVEIKDPLTDEI----- 234 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTG 284 G SG+ + +L I+ + + I G+GGI + EDA + GA+ + + TG Sbjct: 235 -RGGLSGEPTRKHSLELIRYAYKNYGNK-LTIVGVGGIFSAEDAYAKIKAGASLVGLITG 292 Query: 285 IMQYGYRIVEDMASGLSHYLADQGFDSLQE 314 + G +V L L + GF S+ E Sbjct: 293 LFFEGPHLVGRANRELVKLLKNDGFSSISE 322 >UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomycetaceae RepID=A3ZNL9_9PLAN Length = 372 Score = 176 bits (447), Expect = 1e-42, Method: Composition-based stats. Identities = 64/328 (19%), Positives = 110/328 (33%), Gaps = 22/328 (6%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G+ FPNP L++ N + G+G +I PR L Sbjct: 52 LESNVAGLTFPNPVGLAAGWDKNGH-ALRLLDSWGFGFAEIGSISAAASLGNRRPRLFRL 110 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIAS-IMGENE---------Q 114 ++ + + + E L + + P V + G + Sbjct: 111 PQDRAIVVNY----GLPNDGAEVIAQRLAKHRIRRPLGVNLVKTNQGPDAAASSAERIVD 166 Query: 115 QWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV-KRGSTLPMLA 173 + A+ V A + N SCP G D P + + A+ P+ Sbjct: 167 DYVCSAQAVHRH-ASYLTLNLSCPNAAG---GKDFFAQPGSIRQLLTALLPLEIACPLFL 222 Query: 174 KMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 K+ PN D E+ + + + P + +G+ Sbjct: 223 KVAPN-PDPAEIERLLEECEPFAAVRGFLFNLPVGKAASLALTTPRQVWEKMPGAVAGQP 281 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 V ++ R I +M + I G GG+ + DA E + LGA+ +Q+ T ++ G +V Sbjct: 282 VAALSNRCIAEMYQRMPRDRYVIIGGGGVFSAADAYEKMGLGASLIQIYTALVYEGPGVV 341 Query: 294 EDMASGLSHYLADQGFDSLQEMVGLANN 321 + GL LA GF + + VG Sbjct: 342 GRINRGLLQLLAADGFSHVGQAVGSGCR 369 >UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding protein n=5 Tax=unclassified Gammaproteobacteria RepID=A0Z3E6_9GAMM Length = 551 Score = 175 bits (443), Expect = 3e-42, Method: Composition-based stats. Identities = 79/312 (25%), Positives = 138/312 (44%), Gaps = 19/312 (6%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDT--GWGGVVFKTIGFFIANEVSPRFDHLVK 66 +F G F + S V + + G + K+IG Sbjct: 4 SFLGKTLSGGFTVPSGIVTTAPSIIQRVIRDMPEIGVITTKSIGLEPRLGYREPVY---- 59 Query: 67 EDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEA 126 F N + +LA+L +L+ D+ L+ SI G + +++ +A++++ Sbjct: 60 SQFAPGCFVNAVGLTNPGAHASLASLGQLRVPE-DRFLLVSIFGGSVEEFVAVAKILEPV 118 Query: 127 GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVA 186 AD E N SCP + + M +GQ P++V + AVK+ + P++ K+TPN+ ++ E+ Sbjct: 119 -ADGFELNLSCPHASGYGM--AMGQDPKIVHEIIAAVKQVVSKPVIPKLTPNVTNIAEIG 175 Query: 187 LAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMR 246 AA GADG+ AINTV + G +++ + + G SGK V P AL+ I+++R Sbjct: 176 QAALDAGADGLCAINTV----GPGYTESHGEAVLS--NGVGGMSGKGVLPTALKCIRELR 229 Query: 247 THPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLAD 306 D PI G GG+ + D GA + + + + ++ S LS L Sbjct: 230 AIT---DKPIIGCGGLSSAADVNAAKHAGATIVGIGSALSGMDTEDLQRYFSTLSKDLDR 286 Query: 307 QGFDSLQEMVGL 318 QG + ++ Sbjct: 287 QGNQAETQIRYD 298 >UniRef50_B3DVT8 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DVT8_METI4 Length = 314 Score = 174 bits (441), Expect = 6e-42, Method: Composition-based stats. Identities = 62/327 (18%), Positives = 120/327 (36%), Gaps = 21/327 (6%) Query: 21 LSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQI 80 + +SP+ E + G VV ++ V D + Sbjct: 1 MGASPLSGSLEGIQELEKAGAAAVVLPSLFEEQI--VKEAIAENPYLDFSG-NYSEFPMS 57 Query: 81 AEHPL--EENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP 138 +E+ L E L +R K +IAS+ G + W A+ ++EAGAD IE N Sbjct: 58 SEYLLTSESYLDFIREAKRKAR-IPIIASLNGRSPGWWCRYAKQIEEAGADGIELNIYPF 116 Query: 139 QMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIA 198 + + + + R V++ +P+ K+ P ++ +A + G +G+A Sbjct: 117 PLDINQPSDSIEMD---TLEIVRLVRKEIQIPLGVKIYPYYTNVGNMAQRFQAAGVNGLA 173 Query: 199 AINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISG 258 N +ID+ + +S +AL +I + + ++ Sbjct: 174 LFNRFLQ-PDIDVENFEIKRGIQLGTSR-------DNRLALSWIAFLYNRLK---LDLAA 222 Query: 259 IGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGL 318 GG+ DA +L GA+ + V + I++ G + M + ++ F SL++ G Sbjct: 223 TGGVMEAVDAIRLILAGASVVMVCSAILEKGIGYIPVMEKEIVEWMERHRFSSLEDWRGS 282 Query: 319 ANNNIVPAE-DLDRSYIVYPRINLDKC 344 + + R V + D+ Sbjct: 283 LSQQGGASPSRFFRLQYVELLADADRR 309 >UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidobacteriaceae RepID=C6A9A6_BIFLB Length = 386 Score = 174 bits (440), Expect = 7e-42, Method: Composition-based stats. Identities = 71/321 (22%), Positives = 116/321 (36%), Gaps = 29/321 (9%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHL 64 L G+ F NPF LS+ NC +M A G+G + A P F L Sbjct: 77 LETNVMGINFANPFGLSAGLDKNC-DMAAVLDHAGFGFETVGSTTSRPCAGNPRPWFHRL 135 Query: 65 VKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 + D+ + ++ +E A RR + L SI N+ Q +L ++ Sbjct: 136 PEYDSMMVHVGLANDGSDVVIERAEDAWRRTQSMQ----LSVSIARTNDDQVGDLNEGIE 191 Query: 125 EAGA---------DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKM 175 + M+E N SCP T ++ ++ + + + P L KM Sbjct: 192 DYCISMERAAGRTAMVEVNVSCPNTTVGEPFTESAENLDKLFAALD--RIERPQPTLVKM 249 Query: 176 TPN--IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 N E G+ N K T +D K + G SG Sbjct: 250 PLNKPWPQFKEFLDVLAAHNVQGVTIANLQKDRTGLDD---------IPKDWLGGLSGGP 300 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIV 293 + I++ F I+G+GG+ T E A E + G++ + + +M G + + Sbjct: 301 CTVASTELIRRTYAEYGD-RFAIAGVGGVFTPEQAYEKIRAGSSLIMFISSLMYRGPQQI 359 Query: 294 EDMASGLSHYLADQGFDSLQE 314 + GL+ L GF S+ E Sbjct: 360 TVLKRGLAKLLRRDGFGSVAE 380 >UniRef50_C2MA24 Dihydroorotate dehydrogenase 2 n=1 Tax=Porphyromonas uenonis 60-3 RepID=C2MA24_9PORP Length = 327 Score = 174 bits (440), Expect = 7e-42, Method: Composition-based stats. Identities = 67/340 (19%), Positives = 132/340 (38%), Gaps = 18/340 (5%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF- 61 DL+ + G+ NP SS + + G G V+ K++ + + Sbjct: 1 MVDLTSHYGGIALRNPIIAGSSGLTASLQQIKALAQAGAGAVILKSLFEEQIEATALQAE 60 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 + + + + +H +E+ L +R K+ D +IAS+ +WE A+ Sbjct: 61 AEMATSYPEGLDYM-LHYTRQHEVEKYLDLIREAKQAI-DIPVIASVNCYRGGEWEAFAQ 118 Query: 122 LVQEAGADMIECNFSCPQMTSHAMGSDVGQ-SPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 +QEAGAD +E N + GSD+ Q +L R V +P++ K++ Sbjct: 119 SIQEAGADALELNVMRIETDPAQRGSDLEQELVDLAISITRTV----QIPVVFKISDRFT 174 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++ +A + G G+ N D+N + + S L+ Sbjct: 175 NILYLAQELVKSGVKGLTCFNKSWQ---TDINIETLEIVQGPVISTGH-----ELYNTLK 226 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 + + +S GG+ + + LL+GA+++QV + + Q+G + M L Sbjct: 227 YTGLLTGKL--PQLAVSASGGVMDYAGVVKSLLVGASSVQVVSALYQHGASYLTKMLEEL 284 Query: 301 SHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 + ++ G+ S+ E G N + ++L + Sbjct: 285 TQWMTQHGYRSIDEFRGNLNASKQSDQELYMRSQFMRYFS 324 >UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FBL7_SACEN Length = 338 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 64/312 (20%), Positives = 111/312 (35%), Gaps = 47/312 (15%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCA-----------KAYDTGWGGVVFKTIGFFIAN 55 ++ + N SSS +G +G V +T+ Sbjct: 18 AVRLGDIHLRNRLVTSSSLLGYGVANAKLIPYGMSPISQFVPLERFGAVTTRTLTVEPRE 77 Query: 56 E--------VSPRFDHLVKEDTGFI-----GFKNMEQIAEHPLEENLAALRRLKEDYPDK 102 L+K + G+ N L+ L R + Sbjct: 78 GHFTTRDQWPLHELPALLKRYGQALRQVDGGWLNAFGWCNVGLDAYL---RDYYPRTRGQ 134 Query: 103 VLIASIMGENEQQWEELARLVQEA----GADMIECNFSCPQMTSHAMGSDVGQSPELVEK 158 I S+ G + +++ L + +A +E N SC + ++E Sbjct: 135 NTIISVGGFSAEEFVTLIDKINDAVPAGDIAAVEFNVSCHNVNFDFN--------AIIES 186 Query: 159 YCRAVKRGSTLPMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMP 218 S P++ K++P+ D A A + G + AINTVK + L+ + G P Sbjct: 187 VLAEAVPRSAHPVILKLSPDY-DYLAHARLAAKHGVSALTAINTVKG---LRLDPETGQP 242 Query: 219 IVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAAT 278 ++ K+ G SG+A+KPI LR + ++R PI GGI T++D E+ GA Sbjct: 243 LL--KNRFGGLSGRAIKPIGLRVVAELRDA--GVKLPIIATGGIRTFDDCREYFWAGADA 298 Query: 279 LQVTTGIMQYGY 290 + + + Y Sbjct: 299 VSLGSATWFASY 310 >UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBI0_BLASB Length = 320 Score = 172 bits (435), Expect = 2e-41, Method: Composition-based stats. Identities = 63/319 (19%), Positives = 130/319 (40%), Gaps = 20/319 (6%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLV 65 S G++ + +S + + + D+ G +V K+ + PR+ Sbjct: 16 SARINGIQLSSCIMNASGALCTTGQELSDLLDSSSGAIVTKSCTRQPRKGNIKPRYFEWN 75 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ- 124 +G N+ ++ L L K K + SI G + ++ L + Sbjct: 76 VGSINSMGLPNL------GIDFYLNFLEEKKTK---KPVFLSISGLSIEEIFFLLKKANF 126 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD--M 182 + IE N SCP + +G D+ + + +E + + P+ K+ P + + Sbjct: 127 SSKITAIELNLSCPNLQEEILGYDLYKIYDFLENVF----KFNEKPLGIKLPPYFKEEYI 182 Query: 183 CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFI 242 ++L + + IN++ + I ++ + ++ ++ G G +KP AL I Sbjct: 183 KNMSLILNQFPIVFVTCINSLPN--GIFVDPRNETSVIQPRNGFGGIGGSIIKPFALANI 240 Query: 243 QQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 ++ T+ +D I G GGI +D E +L GA+ +Q+ T +M+ G + E + + Sbjct: 241 RKFYTYLR-KDISIIGCGGISYGKDIFEHILCGASAVQIGTQLMKEGISVFERLKKEFTL 299 Query: 303 YLADQGFDSLQEMVGLANN 321 +L + + S+ G N Sbjct: 300 FLQKKNYSSINSFKGKLKN 318 >UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaproteobacteria RepID=PYRD_WIGBR Length = 337 Score = 172 bits (435), Expect = 3e-41, Method: Composition-based stats. Identities = 57/309 (18%), Positives = 115/309 (37%), Gaps = 32/309 (10%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHLV 65 +I+ G+ F N L++ N + D G+G + T+ E PR Sbjct: 46 NISCMGLNFKNILGLAAGLDKNG-DYIKLFSDIGFGFIELGTVTLKPQHGEKKPRLFCFP 104 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR---- 121 G I L EN+ + +K ++ +G+N+ E A+ Sbjct: 105 -NVYGIINRMGFNNNGIENLIENIKNEKNVKS------ILGINIGKNKDTLIEKAKDDYL 157 Query: 122 -LVQEAGA--DMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL-----PMLA 173 + +A D I N S P +L++ + + + P+L Sbjct: 158 ICINKAYYYSDYISINISSPNTKDLRKLQFGELFSDLLKSIKEEQNKLNKIYNKYVPILI 217 Query: 174 KMTPNI--GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSG 231 K++P+I ++ +++ DG+ A NT + I G SG Sbjct: 218 KISPDINNSEIIQISDCLLSYNIDGVIATNTTVNKDII--------MRCCNNCEKGGLSG 269 Query: 232 KAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 + + R I+++ + + I GI + + A E + GA+ +Q+ +G++ +G + Sbjct: 270 APLNENSTRIIKKLSKELKGKIPIIGSG-GIISVKSAKEKIKAGASLIQIYSGLVFFGLK 328 Query: 292 IVEDMASGL 300 I++ + Sbjct: 329 IIKKLIKSF 337 >UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus RepID=C0WNB5_LACBU Length = 315 Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 120/318 (37%), Gaps = 17/318 (5%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 L +F N ++ + K + GG V K+ SPR Sbjct: 7 SLKANIGKYRFNNVLLNAAGIRCATTDELTKILRSTAGGCVTKSATPQPREGNESPRMKA 66 Query: 64 LVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLV 123 +G N + H L+ L + D +I SI G + Q E+ + Sbjct: 67 TP------LGCINSMGLPNHGLDYYLKFAEE-NQRKNDNQVILSIAGLSVDQNLEMLHQI 119 Query: 124 QEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG-- 180 Q++ D + E N SCP + S + E V T + K+ P Sbjct: 120 QDSLFDGLTELNLSCPNIKGE---SQIAYDFEAVRDILTKAFDFFTKDIGIKLPPYFDLH 176 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 ++A + +IN++ + + +N + ++ K G G VKP AL Sbjct: 177 QFDQIADVLNEFPIAYVNSINSIGN--GLIVNPETESVVLKPKGGFGGLGGDYVKPTALA 234 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 ++ +R + + I G GGI++ D E +L GA +Q+ T +I + ++ L Sbjct: 235 NVRGLRLRLK-PEIAIIGTGGIKSGRDVFEHILCGANVVQIGTAFGFEDVKIFDRISKEL 293 Query: 301 SHYLADQGFDSLQEMVGL 318 +A++G+ SL + G Sbjct: 294 KEIMAEKGYTSLDDFRGK 311 >UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/Pelodictyon group RepID=B3EIF4_CHLL2 Length = 375 Score = 171 bits (434), Expect = 4e-41, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 122/350 (34%), Gaps = 37/350 (10%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + DLS T+ G+K NP +SS + E G G VV K++ Sbjct: 47 IMADLSTTWMGLKLRNPLIAASSGLTGTLEGVKAVASHGAGAVVLKSLFEEQ-------- 98 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLK------------EDYPDKVLIASIM 109 + +TGF +N + E+ + R + D +IASI Sbjct: 99 ---IMLETGFAEGQNAQHHYYAQAEDYIREYTRGNALNGYLDLITSCKLAVDIPVIASIN 155 Query: 110 GENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTL 169 ++ +W A ++ AGAD +E N ++ ++ L + R + Sbjct: 156 CVSQGEWLSFASQIERAGADGLEINIF---LSPSDSSRSSTENERLYGDVLENITRVVRI 212 Query: 170 PMLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGY 229 P+ AK++ + A++ G G+ N S + D+ ++ + Sbjct: 213 PVAAKISSYFSSLAAEAVSLSHSGIRGLVLFNRFFS-PDFDIETFDV-------TAGGVF 264 Query: 230 SGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYG 289 S +LR++ + + ++ G+ + LL GA +++ + + + G Sbjct: 265 SSPTDIYHSLRWVAILSGRVQ---CDLAASTGVHDGNGLIKQLLAGARAVEIASVLYKKG 321 Query: 290 YRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRI 339 + M L Y+ Q F S E +G + L Sbjct: 322 LGEIGIMLGELEEYMERQRFSSTGEFIGRMSMAHAANPALYERVQFMKYF 371 >UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Clostridium botulinum RepID=C3KS38_CLOB6 Length = 298 Score = 171 bits (432), Expect = 7e-41, Method: Composition-based stats. Identities = 75/312 (24%), Positives = 136/312 (43%), Gaps = 27/312 (8%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 L G+K NP ++SS + + + K D G G V+ KTI E + + ++ Sbjct: 10 LQTEVLGMKLKNPVIIASSNLTDNEKSIRKFLDLGVGAVITKTIY---IGEKNIQSGRIL 66 Query: 66 KEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 ++++ N ++ + E L +L ++ + +I SI+ + + + LA ++E Sbjct: 67 RKESQIF---NSTTYSKKSISEWTEILSKLYKE--NLPVIPSIVADTKDELVNLALQMEE 121 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCEV 185 G +E SCP E + + RAV R ++P+ K+T + + E Sbjct: 122 VGCKALELGISCPNEIGIN---------EKIYDFTRAVCREVSVPVSVKLTSEVK-VEEK 171 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A GA ++ + SI I +N +P+ GYSG A+KPI + I + Sbjct: 172 VRKAMCAGAKSVSISD---SIPAIVVNTDGTLPL----GVRCGYSGPAIKPIVQKNIYYL 224 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHYLA 305 + D + GIGGIE D E+L +G++ +++ + I G VE + L + Sbjct: 225 KK--NNADVEVIGIGGIENANDVLEYLYVGSSAVELCSCIFINGINQVERIIHDLKNMFL 282 Query: 306 DQGFDSLQEMVG 317 D G + + Sbjct: 283 DMGITVPEIINK 294 >UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobacillales RepID=A0NIQ6_OENOE Length = 329 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 54/320 (16%), Positives = 113/320 (35%), Gaps = 18/320 (5%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTG-WGGVVFKTIGFFIA-NEVSPRF 61 D + F + F ++ E + + G V+ K+ PR+ Sbjct: 18 MDYTTKIANQVFHHLFINAAGVYCQTVEELEQIQNAPCAGAVITKSATAKERSGNSEPRY 77 Query: 62 DHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELAR 121 ++ N + ++ L + + + SI+G ++ + + + Sbjct: 78 FE----NSVEHNTINSMGLPNLGIDYYLNYV---LKHSLKLPTLFSIVGLSQSEIIDNLK 130 Query: 122 LVQEAGADMI-ECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIG 180 +Q +G + E N SCP + + + V + P+ K+ P Sbjct: 131 KLQASGFSGLTELNLSCPNVPGKP---QIAYDFTATREILDNVFAFYSKPLGVKLPPYFD 187 Query: 181 --DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 ++A + AIN+V + + ++ + P++ K G GK +K A Sbjct: 188 TAHFDQIASILNDYPLTYVNAINSVGN--GLVIDPETDTPVIKPKDGFGGLGGKQIKATA 245 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 L ++ +R I GG+ D + LL GA + + + + G + + Sbjct: 246 LANVRALRQRLY-PQIKIIATGGVTNGRDVYDHLLCGADLISIGSQLEIEGPTVFARLEK 304 Query: 299 GLSHYLADQGFDSLQEMVGL 318 L AD+G L+++ G Sbjct: 305 ELEEIFADKGITDLRQVRGK 324 >UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVZ1_RUBXD Length = 304 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 125/294 (42%), Gaps = 30/294 (10%) Query: 1 MLTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSP 59 M+ +LS+ CGV+ P +S + E +A +G V+ KT+ P Sbjct: 1 MVAPELSVELCGVRLATPLIPASGTLA--PEALGEAAGV-YGAVLPKTVTLRPRQGNPPP 57 Query: 60 RFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 R IG +N LR L + S+ GE +++ L Sbjct: 58 RVAESPAGMVNSIGLQNPGV---------EEFLRALGAWEVGVPVFVSVAGETVEEFALL 108 Query: 120 ARLVQEAG-ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGS-TLPMLAKMTP 177 V G A IE N SCP + G P VE+ A +R + +P+LAK+ Sbjct: 109 CGRVAADGRAAAIELNLSCPNVE--RGGQVFCAGPSAVEEVVAACRRAAPDVPLLAKLA- 165 Query: 178 NIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + + ALAA+ GADG+ +NTV + ++ + ++ G SG A+KP+ Sbjct: 166 -LEGVVQNALAAEAAGADGLTVMNTV---PALAVDARARRVLLR-----GGLSGPAIKPL 216 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYR 291 ALR + + + E P+ G GG+ + D AEF+L GA +QV + Sbjct: 217 ALRAVYDVASAAE---IPVVGCGGVCSGADVAEFMLAGARAVQVGSAGFVRDPA 267 >UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVY1_9BACT Length = 325 Score = 169 bits (428), Expect = 2e-40, Method: Composition-based stats. Identities = 73/344 (21%), Positives = 125/344 (36%), Gaps = 25/344 (7%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLV 65 + + G+ P+P +SSSP + + + +G G VV K+I H Sbjct: 1 MRAKYLGLDLPSPIIVSSSPYTSNVKSVEQCAASGAGAVVLKSIFEEQI------LHHAA 54 Query: 66 KEDTGFIGFKN-MEQIAEHPLEENLA----ALRRLKEDYPDKVLIASIMG-ENEQQWEEL 119 DT E + L E+ L + + +IASI ++ W E Sbjct: 55 ALDTVSDSAYGDAEVYLQRYLGEDYKAGFLRLVQEARSKTELPVIASINCVVDKGDWIEY 114 Query: 120 ARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 A + +AGA +E N HA ++ + + V +P+ K+ + Sbjct: 115 ATAMADAGASALELNIFIQSTDIHAQARELELNY---AEIVGRVAGAVKIPVSVKLPMRL 171 Query: 180 GDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIAL 239 ++ ++ A GA G+ N ++D+ + + S YS L Sbjct: 172 TNVFALSSALLGHGARGVVFFNRFFE-PDVDVERMTFV-------ESSPYSEPTELRNVL 223 Query: 240 RFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASG 299 R + D + G+ E A + LL GA +QV T I Q G+ ++ +M Sbjct: 224 RMVAICSAVLPQLDLSV--STGVHDGEAAVKALLCGAEAVQVCTAIHQKGFEVIAEMNEY 281 Query: 300 LSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLDK 343 + + QGF SL E G N + R + + K Sbjct: 282 IDRWSERQGFGSLDEFRGRLNFKNDTSAMFQRVQYMKYFPSEAK 325 >UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotogaceae RepID=PYRD_THEP1 Length = 270 Score = 168 bits (426), Expect = 3e-40, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 124/295 (42%), Gaps = 34/295 (11%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKEDTGF 71 ++ P L S P G E GGV+ KT+ +PR D Sbjct: 2 LELKPPLVLLSGPAGFG-EYLKLMDHRYVGGVLLKTVTLHPKEGNPTPRM---ADSDFYV 57 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGAD-- 129 I +E H EN+ L +IAS+ G++ +++ E+AR+ ++ AD Sbjct: 58 INRIGLENPGIHAFVENIPELP--------VPMIASLGGDSFEEYLEVARVFKKV-ADRF 108 Query: 130 -MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP-MLAKMTPNIGDMCEVAL 187 +E NFSCP + G + ++ E +K +++ ++AK+ + + A Sbjct: 109 YAVEFNFSCPNVKEG--GLSIVKNAEEWKKLLNTLRKELPDSFLIAKVGVEGIFVEDAAE 166 Query: 188 AAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRT 247 + G DGI +NTV+ + + G SG +KPIALR + +++ Sbjct: 167 FVMKTGWDGITLVNTVRG-----------LHFEKDTMILGGLSGPVLKPIALRAVYEVKK 215 Query: 248 HPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSH 302 + + GG+ + +DA EFL +GA + V + + +VE++ L Sbjct: 216 RF--PELFVIASGGVYSVKDAEEFLKVGADVIGVGSALF-KDPGVVEEIGKYLLE 267 >UniRef50_C4T7U5 Dihydropyrimidine dehydrogenase n=1 Tax=Yersinia intermedia ATCC 29909 RepID=C4T7U5_YERIN Length = 397 Score = 168 bits (425), Expect = 4e-40, Method: Composition-based stats. Identities = 87/416 (20%), Positives = 170/416 (40%), Gaps = 41/416 (9%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI--ANEVSP 59 +++ L + F G K +P + + P +A G G + K+IG+ + Sbjct: 4 MSQRLFVDFMGKKLCSPIIVGAGPSTKSCSDIIEAAKFGAGAAIIKSIGWHADVEKTLKD 63 Query: 60 R-FDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG------EN 112 R +K ++ + +I P NL ++ +K D + AS+ + Sbjct: 64 RKRYRWIKGYGTYLKSTYLCEILSKPYGCNL--IKEVKSS-SDIPIYASVFYPALSNEHD 120 Query: 113 EQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPML 172 +W +L V AG D ++ +F + +V + + + CR + LP++ Sbjct: 121 IDRWIDLVSEVSNAGCDGVQLDFFYLDLRKLND-DEVCFFVDAINRICR----STHLPVM 175 Query: 173 AKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIG----MPIVNGKSSISG 228 K+ + D + K +D I+++ + ID+ K + N +++ SG Sbjct: 176 PKLNIAMDDDL-IENLLKNSLSDAYVFIDSINTEPYIDIWNKGAPLFDGQLYNSQTNRSG 234 Query: 229 --YSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 +G+A+ P Q++ D +S GG+E WED ++LGA+T+ +T+ +M Sbjct: 235 SVVAGEALLPFTFNMTQRLYRST---DKNLSAGGGLEHWEDIIRCIMLGASTVHLTSILM 291 Query: 287 QYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAE--DLDRSYIVYPRINLDKC 344 + G++ + D+ S +++YL Q + + ++ G++ + + I+ KC Sbjct: 292 RRGFKYIRDLNSSINNYLDKQHVEKISDIRGVSYSTNAGNTIIQQKPILDMRAIIDSSKC 351 Query: 345 VGCGRCY--ISCYDGGHQAMEWSEKTRTPHCNTEKCVGCLLCGHVCPVGCIELGEV 398 CG C C + P+ C GC C +CP I L V Sbjct: 352 NDCGVCERFKVC----------DSFSVKPYDFINNCDGCTYCLALCPRNAISLIGV 397 >UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bacteroides RepID=B5CXJ8_9BACE Length = 349 Score = 167 bits (422), Expect = 1e-39, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 102/298 (34%), Gaps = 37/298 (12%) Query: 13 VKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFI-ANEVSPRFDHLVKEDTGF 71 + F N LS+ + D G+G + T+ A PR L + D Sbjct: 75 LTFANRVGLSAGFDKE-ANCFDELSDLGFGFLEVGTVTPEKVAGNPFPRIFRLPE-DHAL 132 Query: 72 IGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE------ 125 + + + +NL R K +L +I E + + Sbjct: 133 VSRTGFNNPGKEVVLKNLQRKREGKY-----ILGVNINTNTPTDAERAVTDITDLYETFS 187 Query: 126 AGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAV---KRGSTLPMLAKMTPNI--G 180 A AD N+ +PE++ A+ K+ P+ K+ ++ Sbjct: 188 AYADYYTINWGS-------------MTPEILADVLTALESYKQRFHRPVFLKLPADVPAE 234 Query: 181 DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALR 240 + V AK DG A + + + + + + + G SG V +L Sbjct: 235 KLDTVIEFAKVHHIDGFIATGPTQDRSLLIHSAQTEV----ERVGAGGISGLPVIHKSLE 290 Query: 241 FIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 ++ + H +D + G GG+ T +A GA +QV + + G +V+ +A Sbjct: 291 VMKHLSAHAP-KDMLLIGAGGVMTPFEAKAMRNAGAHLVQVYSAFIYEGPGVVKRIAE 347 >UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobaceae RepID=PYRD_SULAC Length = 291 Score = 166 bits (419), Expect = 2e-39, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 121/299 (40%), Gaps = 30/299 (10%) Query: 8 ITFCGVKFPNPFCLSSSPVGNCYEMCAK-AYDTGWGGVVFKTIGFFIANEVSPRFDHLVK 66 I GV F +P ++S V E + KT+ + + Sbjct: 2 IQVAGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKIS 61 Query: 67 ED--TGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQ 124 ++ IG N + LR L E LI SI G N ++ + + Sbjct: 62 DNCYLNAIGLGNPG----------IQILRDLGEIKCK--LIISIGGSNVNEYIDAVSKIN 109 Query: 125 EAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMCE 184 + MIE N S P + VE+ + VK P+ K+ P ++ E Sbjct: 110 DIPV-MIELNVSSPNRRGFG-----ESNLTYVEEIVKNVKSIVKKPVFVKLGP-WDNIVE 162 Query: 185 VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQ 244 +A A GADG+ INT+K + ++ + PI++ G SGK + +A+R I Sbjct: 163 IAGRALSAGADGLTLINTLKGML---IDVEDFKPILSY--GTGGISGKCIHALAVRVIHD 217 Query: 245 MRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGLSHY 303 + E I G+GG+ W DA E + +GA + + T +++ G+ ++ ++ G+ Y Sbjct: 218 VFKEYE---PEIIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGIGTY 273 >UniRef50_Q2LR94 TRNA-dihydrouridine synthase n=2 Tax=Deltaproteobacteria RepID=Q2LR94_SYNAS Length = 326 Score = 165 bits (418), Expect = 2e-39, Method: Composition-based stats. Identities = 44/270 (16%), Positives = 103/270 (38%), Gaps = 44/270 (16%) Query: 44 VVFKT------IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKE 97 +V + + +S ++ + G E I+ + L + ++ + Sbjct: 2 IVIGSLIIKNNVILAPMAGISNLPFRMMAREAG-CALAFTEMISANGLVRGIEKSQQYMK 60 Query: 98 D-YPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPE 154 DK L I G + + R+V + GAD+I+ N CP ++ + G+ + + P Sbjct: 61 SCIDDKPLGVQIFGNDPTTMADAVRIVDDYGADLIDLNMGCPVKKVVKNGAGAALLKDPG 120 Query: 155 LVEKYCRAVKRGSTLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNID 210 LV + +V++ + P+ K+ + ++A A++ G D + Sbjct: 121 LVSQILESVRKATRKPLTVKIRSGWNLQSINAVQIARIAEQQGIDAV------------- 167 Query: 211 LNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAE 270 V+ ++++ G++G A R I++++ + G G +++ DA Sbjct: 168 --------FVHARTAVQGFAGSAD----WRIIEEIKNSVG---IKVIGNGDVKSGADAWR 212 Query: 271 F-LLLGAATLQVTTGIMQYGYRIVEDMASG 299 + G + + G + I + + Sbjct: 213 MIKMTGCDGVMIGRGALGN-PWIFNEALNY 241 >UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 Tax=Leotiomyceta RepID=B2WMQ8_PYRTR Length = 455 Score = 165 bits (418), Expect = 3e-39, Method: Composition-based stats. Identities = 50/294 (17%), Positives = 89/294 (30%), Gaps = 43/294 (14%) Query: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDH 63 DL++ G NP S+ E+ ++ G G V + PR Sbjct: 23 DLAVEVFGHTLNNPIGTSAGIDK-GAEIPTPLFELGAGVVEVGAVTLLPQEGNPKPRVFR 81 Query: 64 LVKEDT--GFIGFKNMEQ-IAEHPLEENLAAL-------------RRLKEDYPDKVLIAS 107 L ++ GF + + L + + RR+ + + Sbjct: 82 LPSQNALINRYGFNSEGAELVASRLRQRVREFAYRIGLGLDEDAERRVLDGEAGVPPGSL 141 Query: 108 IMG---------------ENEQQWE-ELARLVQEAG--ADMIECNFSCPQMTSHAMGSDV 149 + G + + A V G AD++ N S P +V Sbjct: 142 LKGRLMAVQVAKNKTTSENDIDAVVRDYATAVGYVGKYADILVVNVSSPNTPGLRTLQNV 201 Query: 150 GQSPELVEKYCRAVKR--GSTLP-MLAKMTPNIGDMCEVA---LAAKRGGADGIAAINTV 203 L+ AVK+ T P ++ K++P+ ++A A G DG+ NT Sbjct: 202 EPLTRLLSGVVSAVKKIDRKTKPAVMVKVSPDEDSESQIAGICEAVWDSGVDGVIVGNTT 261 Query: 204 KSITNIDLNQ-KIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPI 256 K + + GYSG + L + + R + + Sbjct: 262 KKRPDPLPKGYLLPESEAKLLLEQGGYSGPQMFERTLALVSKYRKALDEGPKHV 315 Score = 43.2 bits (100), Expect = 0.020, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 25/66 (37%) Query: 237 IALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDM 296 I L+ + P+ I GGI A E L GA+ QV T ++ G + + Sbjct: 379 ITLQATPKAAPAPDAPRKVIFATGGITNGRQAREILDAGASVAQVYTAMIYGGAGTISRI 438 Query: 297 ASGLSH 302 + Sbjct: 439 KQEMRD 444 >UniRef50_C4Z9L8 tRNA-dihydrouridine synthase n=26 Tax=Firmicutes RepID=C4Z9L8_EUBR3 Length = 323 Score = 163 bits (412), Expect = 1e-38, Method: Composition-based stats. Identities = 54/314 (17%), Positives = 106/314 (33%), Gaps = 40/314 (12%) Query: 33 CAKAYDTGWGGVVFKT-IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAA 91 + G V + V+ L+ ++ G G ME ++ + Sbjct: 3 IHQIRKLQIGSVTLPNNLILGPMAGVTDLPFRLLCKEQGA-GLLCMEMVSAKAILYKNKN 61 Query: 92 LRRLKE-DYPDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSC--PQMTSHAMGSD 148 L D +K + + G + Q ++A+ ++E D+++ N C P++ ++ GS Sbjct: 62 TESLLSIDEREKPVSLQMFGSDPQIMAQIAKQIEERPFDILDINMGCPVPKIVNNGEGSA 121 Query: 149 VGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD----MCEVALAAKRGGADGIAAINTVK 204 + ++P L + ++ + P+ K+ D E+A A+ GA +A Sbjct: 122 LMKNPLLAGQIIESIVKAIDKPVTVKIRKGFDDEHVNAVELAHVAEESGASAVA------ 175 Query: 205 SITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIET 264 V+G++ YSGKA I +R E P+ G G + + Sbjct: 176 ---------------VHGRTREQYYSGKADWDI-------IRQVKEAVSIPVIGNGDLLS 213 Query: 265 WEDAAEFLL-LGAATLQVTTGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNI 323 ED + G + G I + Q S +E+ + + Sbjct: 214 AEDVIKMQEQTGCDGFMIARGAQGN-PWIFSQILHYF-ETGEHQEKPSFEEVRRMILRHA 271 Query: 324 VPAEDLDRSYIVYP 337 + Y Sbjct: 272 RMMIEFKGEYTGIH 285 >UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=A2QCB1_ASPNC Length = 544 Score = 161 bits (408), Expect = 4e-38, Method: Composition-based stats. Identities = 50/375 (13%), Positives = 90/375 (24%), Gaps = 81/375 (21%) Query: 6 LSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFDHL 64 L G NP +S + ++ ++ G V PR L Sbjct: 171 LLTEVFGYTLSNPIGISGGLDKH-ADIPDPLFELGPAIVEVGGTTPLPQDGNPRPRVFRL 229 Query: 65 VKEDTGFIGFKNMEQIAEHPL------------------EENLAALRRLKEDYPDKV--- 103 + I + + E LA R L + Sbjct: 230 PSQKA-MINRYGLNSKGADHMAAVLEQRVRDYAYAHGFGEHELAEQRVLNGEAGVPPGSL 288 Query: 104 -----LIASIMGE--NEQ--------QWEELARLVQEAGADMIECNFSCPQMTSHAMGSD 148 L + + + + AD++ N S P Sbjct: 289 REGKLLAVQVAKNKLTPDNDIEAIKRDYVYCVDRLAKY-ADILVVNVSSPNTPGLRDLQA 347 Query: 149 VGQSPELVEKYCRAVK--RGSTLP-MLAKMTPNIGDMCE---VALAAKRGGADGIAAINT 202 +++ A K T P ++ K++P+ + + A G DG+ NT Sbjct: 348 TAPLTAILKAVVGAAKSIDRKTKPFVMVKVSPDEDADEQVSGICDAVWGSGVDGVIVGNT 407 Query: 203 VKSITNIDLNQKI-GMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELR--------- 252 + GYSG + + + + R+ + Sbjct: 408 TNRRPEPLPKGFTLPSKEQDVLKETGGYSGPQLFDRTVALVARYRSLLDASAPAAAAVPK 467 Query: 253 -------------------------DFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 I GG+ A + L GA+ + T I Sbjct: 468 ALEAAEPDVENVPPTVSEAVEGLPARKVIFASGGVTNGAQARKVLDAGASVAMMYTAITY 527 Query: 288 YGYRIVEDMASGLSH 302 G V + + Sbjct: 528 GGLGTVTRVKEEMKE 542 >UniRef50_B3EQ67 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B3EQ67_CHLPB Length = 328 Score = 161 bits (407), Expect = 5e-38, Method: Composition-based stats. Identities = 74/350 (21%), Positives = 123/350 (35%), Gaps = 37/350 (10%) Query: 3 TKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFD 62 DLS T+ G+K NP SS + E KA D G G VV K++ + Sbjct: 1 MADLSTTYMGLKLKNPVIAGSSGMTESVESVTKAADAGAGAVVLKSLFEEQIHN------ 54 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLK------------EDYPDKVLIASIMG 110 ++G+ N + EE + R +D D +IASI Sbjct: 55 -----ESGYAIDSNEQDYYYAQAEEYIRNYTRGNDLRAYLDLISGCKDAVDIPVIASINC 109 Query: 111 ENEQQWEELARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLP 170 + +W + A Q AGAD +E N D GQS ++ V ++P Sbjct: 110 VSSSEWTDFAVQAQRAGADGLELNMFMLPSDPDR---DSGQSEQVYLDVLEKVTGLISIP 166 Query: 171 MLAKMTPNIGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYS 230 + AK++ + + G G+ N S +ID+ +S Sbjct: 167 VAAKISYYFSGLANIVEKIASTGISGLVMFNRFFS-PDIDIENFEVKSTNV-------FS 218 Query: 231 GKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGY 290 ++LR++ + + I+ GI + + LL GA Q+ + + GY Sbjct: 219 SPQDLSLSLRWVAMLSSRVP---CDIAASTGIHDGKALIKQLLAGAKAGQIASVLYSEGY 275 Query: 291 RIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRIN 340 ++ M L Y+ F +L EM+G + + Sbjct: 276 EVISPMLEELDAYMERHNFSTLDEMIGKMSFEKSGNPAAYERVQFMKYFS 325 >UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroides RepID=C6IFT5_9BACE Length = 332 Score = 161 bits (406), Expect = 5e-38, Method: Composition-based stats. Identities = 52/305 (17%), Positives = 114/305 (37%), Gaps = 33/305 (10%) Query: 9 TFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFDHLVKE 67 ++ ++F N LS+ N E + D G+G + T+ SPR LV++ Sbjct: 50 SYGSLRFKNRIGLSAGFDKN-AETFDELADFGFGFLEVGTVTPDYQPGNPSPRIFRLVED 108 Query: 68 DT--GFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 ++ GF N ++ L +R+ ++ + + + + ++ + + Sbjct: 109 ESLISRTGFNNC------GVDVALEHIRKYRKHSYRLGVNINKNPLSAGE--QIIKDFEL 160 Query: 126 A------GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNI 179 D N+ + E + + +AV + + + K+ +I Sbjct: 161 VFTRLYESVDYFTLNWGS------IDKESFAKVLENLTTFRQAVNKRCS--IFIKLPADI 212 Query: 180 GD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPI 237 + + V A + +G A + + + + + G SG+ + Sbjct: 213 DEKALDLVISLAYKYSIEGFIATGPTMDRSELHHTKTKQLEKIGN----GGVSGRGIGKK 268 Query: 238 ALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMA 297 + + ++ + H + I G GGI T EDAA+ + GA +Q+ + + G +V + Sbjct: 269 SQKVVRYLSGHTDHHFL-IIGAGGIMTAEDAADMISQGADMIQIYSAFIYSGPSVVHKIG 327 Query: 298 SGLSH 302 L H Sbjct: 328 KKLKH 332 >UniRef50_Q7US31 Putative uncharacterized protein n=1 Tax=Rhodopirellula baltica RepID=Q7US31_RHOBA Length = 337 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 61/344 (17%), Positives = 118/344 (34%), Gaps = 18/344 (5%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRF 61 + L+ F G+ +P + +SP+ + + G G +V ++ + S Sbjct: 1 MPSRLNTQFGGLSLRSPVVVGASPLSMNERTRMEMQEAGAGAIVLPSLFEEQVIDWSWNH 60 Query: 62 DHLVKEDTGFIGFKN---MEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEE 118 + I ++ + LA + R D +IAS+ G W + Sbjct: 61 GRQLTPKERMILGQSDRTKHHWVCPDGDSYLALVNR-ASSLQDIPIIASLNGYTAGGWMD 119 Query: 119 LARLVQEAGADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPN 178 A ++EAGA IE N + + + R V T+P+ K++ N Sbjct: 120 FAGELEEAGASAIELNV---HHSGAREYGSSAEIEMTILDSIRDVNSAITVPLFVKLSSN 176 Query: 179 IGDMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIA 238 + +A GA G+ +I L+ S+ G + Sbjct: 177 FTSLPHIARQLL-SGAQGMVLHGRAP-KVDICLDTLRLASRWRITSADEGV-------DS 227 Query: 239 LRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMAS 298 L + Q+ + P++ GG+ + + LL GA VT+ I + G +++ M Sbjct: 228 LDTLMQVHSCCPA--MPLAACGGVGNADHLIKVLLAGADVAMVTSAIYREGASVIQTMLR 285 Query: 299 GLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVYPRINLD 342 GL ++ S+Q++ E+ + Sbjct: 286 GLVSFMEKHDMQSMQDLKTQRPLEFSSDEERTAYIAALTAHLRE 329 >UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G610_PHATR Length = 387 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 66/345 (19%), Positives = 131/345 (37%), Gaps = 24/345 (6%) Query: 2 LTKDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-FFIANEVSPR 60 + +L+ T G+ +S P +K + G V+ K+ + PR Sbjct: 1 MVVELATTVAGILLKTCVYNASGPRSGTSTALSKVAQSASGAVLAKSATVQKQSGNPQPR 60 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEENLAA---LRRLKEDYPDKVLIASIMGENEQQWE 117 H I N E + + ++ + A +K+ DK S+ G++ Sbjct: 61 TWHHPDY----IASFNSEGLPNNGIDYYIDATTIDDAMKDADDDKPYFVSLSGKSLHDNM 116 Query: 118 ELARLVQEA----GADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGST--LPM 171 E+ + A IE N +CP + + + + ++ V + + P+ Sbjct: 117 EMLHKIASAPTKNRISAIELNLACPNVIGKPI---IAYDVDQMDSILEQVSQLTDSLPPL 173 Query: 172 LAKMTPNIG--DMCEVALAAKRGG--ADGIAAINTVKSITNIDLNQKIGMPIVNGKSSIS 227 K+ P + + A R +A+INT+ + +D+ + P ++ S + Sbjct: 174 GVKLPPYLDFQHFQQAASVLNRHKKLVKYVASINTLGNALAVDVVSEA--PCISSNSGFA 231 Query: 228 GYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQ 287 G SG AV AL ++++R + D + G+GG+ + +D LL GA +QV T Sbjct: 232 GLSGPAVHYTALANVRKLRELLDE-DIDVVGVGGVRSGKDVFAMLLAGATAVQVGTCHWI 290 Query: 288 YGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRS 332 G + + L + ++G ++++ G R Sbjct: 291 EGPSCFDRIVDELRVLMEEKGCRRIEDVKGKLKAWSKEGAAKSRQ 335 >UniRef50_C9XSF8 tRNA-dihydrouridine synthase n=24 Tax=Clostridia RepID=C9XSF8_CLODC Length = 322 Score = 158 bits (399), Expect = 4e-37, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 101/268 (37%), Gaps = 39/268 (14%) Query: 42 GGVVFKT-IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRR-LKEDY 99 G + K + V+ L+ ++ G G E I L + ++ LK + Sbjct: 4 GNLELKNKVFLSPMAGVTDLPFRLICKEQG-CGLLYTEMINGKALCYDDENTKKMLKIEE 62 Query: 100 PDKVLIASIMGENEQQWEELARLVQEAGADMIECNFSC--PQMTSHAMGSDVGQSPELVE 157 + + I G + A ++ + ++++ N C P++ + GS + ++P+L E Sbjct: 63 EEHPVAVQIFGSEPEFMGRAAEIMNDYSNEILDINMGCPAPKVVKNGDGSALMKNPKLAE 122 Query: 158 KYCRAVKRGSTLPMLAKMTPNIGD----MCEVALAAKRGGADGIAAINTVKSITNIDLNQ 213 + RAV + S P+ K+ D E+A A+ G +A Sbjct: 123 EVLRAVVKNSKKPVTLKIRKGWDDNSVNAVEIAKIAEDCGISALA--------------- 167 Query: 214 KIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL- 272 ++G++ Y+GKA I +++ + P+ G G + T ED+ L Sbjct: 168 ------IHGRTREQFYTGKAD----WDIIAEIKKNL---SIPVIGNGDVFTIEDSINMLD 214 Query: 273 LLGAATLQVTTGIMQYGYRIVEDMASGL 300 G + + G I + + + Sbjct: 215 KTGCDAIMIGRGAQGN-PWIFKRINHYM 241 >UniRef50_C8W3U6 TIM-barrel protein, nifR3 family n=8 Tax=Clostridia RepID=C8W3U6_DESAS Length = 322 Score = 155 bits (391), Expect = 3e-36, Method: Composition-based stats. Identities = 50/269 (18%), Positives = 94/269 (34%), Gaps = 39/269 (14%) Query: 39 TGWGGVVFKT-IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKE 97 G V K + ++ R ++ ++ G G E I++ L L + Sbjct: 2 LRIGNVTIKNRVISAPMAGITDRAYRILAKEAG-CGLVCTEMISDQALLYGNPKTNILLD 60 Query: 98 DYPDKVLI-ASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPE 154 + I I G + + A + + GA +I+ N CP ++ + G+ + + PE Sbjct: 61 CTGETPPISMQIFGSSPEYMARAASITEARGASIIDINMGCPTPKIVKNGEGAALMRKPE 120 Query: 155 LVEKYCRAVKRGSTLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNID 210 L +K V + +P+ K+ + E+AL A+ GA + Sbjct: 121 LAQKIISDVVQSVRVPVTVKIRKGWDESFPNAVEMALLAEEAGAKAVT------------ 168 Query: 211 LNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAE 270 V+G++ YSGKA I +++ + P+ G G I DA Sbjct: 169 ---------VHGRTRSQFYSGKADWDI-------IKSVKKAVTIPVIGNGDIREPRDAVR 212 Query: 271 F-LLLGAATLQVTTGIMQYGYRIVEDMAS 298 + G + + + I Sbjct: 213 MLMHTGCDAVMIGRASLGN-PWIFSSTVH 240 >UniRef50_C0WDP2 Putative uncharacterized protein n=1 Tax=Acidaminococcus sp. D21 RepID=C0WDP2_9FIRM Length = 321 Score = 154 bits (389), Expect = 6e-36, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 88/257 (34%), Gaps = 36/257 (14%) Query: 49 IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI 108 + V+ ++ + G + A+ L +N L D + + Sbjct: 11 VVLAPMAGVTDLPFRVICRENGADYTVSEMVSAKALLYKNQKTFAMLTIDPKEHPTAIQL 70 Query: 109 MGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRG 166 G + ++V+ GADMI+ N CP ++ S+ GS + + P+ V A+ Sbjct: 71 FGSVPSELAAAGKIVESRGADMIDVNMGCPVHKIVSNGEGSALMKDPDKVYAILAALVDA 130 Query: 167 STLPMLAKMTPNIGDMCE----VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 ++P+ K + + +A A++ G + V+G Sbjct: 131 VSIPVTVKFRAGWDEAHKNAAVIAQMAEKAGVSAVC---------------------VHG 169 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL-LLGAATLQV 281 ++ Y GKA I +R E P+ G G I EDA G + + Sbjct: 170 RTRAQFYQGKADWDI-------IRAVKESVGIPVLGNGDIFHAEDALRMKEETGCDGVMI 222 Query: 282 TTGIMQYGYRIVEDMAS 298 G I D+ + Sbjct: 223 ARGAEGN-PWIFRDVKA 238 >UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5N0_THEAS Length = 316 Score = 154 bits (389), Expect = 6e-36, Method: Composition-based stats. Identities = 70/283 (24%), Positives = 124/283 (43%), Gaps = 22/283 (7%) Query: 7 SITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPRFDHLVK 66 ++ G+ +P ++S + E+ + G G + K I R + LV+ Sbjct: 17 NVDLNGLGLSSPVVVASGVLPMDGEVWSSME--GVGLICTKGITLEPRAG--NRGERLVE 72 Query: 67 EDTGFIGFKNMEQIA-EHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQE 125 +G + +E + LE L L R + L ++ + + EEL + + Sbjct: 73 TPSGLLNSIGLENPGIDRFLEAILPDLLRSRRS-----LGLNVAFSSLGELEELIGRIGD 127 Query: 126 AGAD--MIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGDMC 183 A ++E N SCP + G+ G+SPE + R + + AK+TP D+ Sbjct: 128 RAASVEVLELNLSCPNVD--REGAVWGESPERTFEAVRLARSLWPRSVWAKLTPQAPDVA 185 Query: 184 EVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQ 243 VA AA+ GA + NT +++ + G P+ K ++G SG AV P+ LR + Sbjct: 186 AVARAAEEAGAHCLVVANTWLG---AEVDLEAGAPVF--KRVVAGLSGPAVLPLTLRLLF 240 Query: 244 QMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIM 286 Q+ P+ GGI + +DA + ++ GA+ +QV T + Sbjct: 241 QLY---PKVSVPLVACGGICSPQDALKAMMAGASAVQVGTQLF 280 >UniRef50_D2RLJ7 TIM-barrel protein, nifR3 family n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RLJ7_ACIFE Length = 331 Score = 154 bits (388), Expect = 7e-36, Method: Composition-based stats. Identities = 50/257 (19%), Positives = 94/257 (36%), Gaps = 36/257 (14%) Query: 49 IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASI 108 I V+ ++ + G + A+ L +N L+ D + + + Sbjct: 19 IALAPMAGVTDLPFRVICRELGADYTVSEMVSAKALLFKNPKTFAMLEVDPREHPVAIQL 78 Query: 109 MGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRG 166 G ++ + A++V E GAD+I+ N CP ++ ++ GS + + PE A+ Sbjct: 79 FGSVPEELVKGAKIVAEHGADIIDFNMGCPVHKIVANGEGSALMKDPERAYACLAALVDA 138 Query: 167 STLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 P+ K + E+A A++ G +A V+G Sbjct: 139 VDRPVTVKFRAGWDEDHRNAVEIARLAEKAGVAAVA---------------------VHG 177 Query: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLL-GAATLQV 281 ++ YSGKA I +R E P+ G G + T +DA + L + + Sbjct: 178 RTRGQFYSGKADWDI-------IRQVKEAVSIPVLGNGDVFTAQDALDLLAATHCDGVMI 230 Query: 282 TTGIMQYGYRIVEDMAS 298 G I ++ + Sbjct: 231 ARGAQGN-PWIFREVQA 246 >UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rhodopseudomonas palustris HaA2 RepID=Q2IVE7_RHOP2 Length = 348 Score = 152 bits (385), Expect = 2e-35, Method: Composition-based stats. Identities = 50/299 (16%), Positives = 96/299 (32%), Gaps = 24/299 (8%) Query: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIA-NEVSPRFD 62 L F GV+ PNP L++ E+ A G+G V +I PR Sbjct: 48 PRLVTRFAGVELPNPVGLAAGFDK-DAELIAALSCLGFGFVCVGSIMPEPRVGNPFPRLV 106 Query: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMGENEQQWEELARL 122 G + + LRRL +IA+I G + Sbjct: 107 R----RRGTESIADSMGVPSKGRAYATERLRRLGPRA--VPVIANIGGFSADTIAAGVIE 160 Query: 123 VQEAGADMIECNFSCPQM-TSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD 181 V D++E + CP + + ++G ++ + G ++ ++ + Sbjct: 161 VAPH-VDLVELSLMCPNVLADGEVFDEIGMLRGVLARL-----DGRAGSIVVRVPNDTTR 214 Query: 182 MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRF 241 + + I + ++I P + + G+ + AL Sbjct: 215 LHDRFAELIE------VCIAAGVGGIKVGGGRRIAEPGLG--TGAGTLHGREIFDTALMN 266 Query: 242 IQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGIMQYGYRIVEDMASGL 300 +++ I G GGI + D GA+ + + + + G+ I D+ L Sbjct: 267 VERAAGFAR-GRLAIKGNGGISSAADVLAMRRAGASCVDLYSAFIYQGWTIARDINRAL 324 >UniRef50_A9KHE5 TIM-barrel protein, nifR3 family n=2 Tax=Clostridiales RepID=A9KHE5_CLOPH Length = 324 Score = 152 bits (383), Expect = 2e-35, Method: Composition-based stats. Identities = 44/262 (16%), Positives = 93/262 (35%), Gaps = 38/262 (14%) Query: 47 KTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLA-ALRRLKEDYPDKVLI 105 + V+ L+ ++ G E ++ + N L+ + ++ + Sbjct: 12 GNLVLGPMAGVTDLPFRLLCKEQGA-DLIYTEMVSAKGIYYNNKNTEVLLEVEEKERPVA 70 Query: 106 ASIMGENEQQWEELARLVQEAGADMIECNFSC--PQMTSHAMGSDVGQSPELVEKYCRAV 163 + GE+ E+A+ ++ D ++ N C P++ ++ GS + PE + + A+ Sbjct: 71 LQLFGEDPYIMSEMAKRIEHRNFDFLDINMGCPVPKVVNNGEGSALMLKPERIGEIVSAI 130 Query: 164 KRGSTLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 + P+ K+ + EVA ++ G IA Sbjct: 131 SKAIKKPVTVKIRKGFTKDNINAVEVAKVIEQSGGAAIA--------------------- 169 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL-LLGAAT 278 V+G++ YSG+A I ++ E P+ G G ++T ED + G Sbjct: 170 VHGRTREQYYSGEADWDI-------IKAVKEAVSIPVIGNGDVQTPEDVKRMMSYTGCDA 222 Query: 279 LQVTTGIMQYGYRIVEDMASGL 300 + + G ++ L Sbjct: 223 VMIARG-VRGNPWFFSQAKHYL 243 >UniRef50_B3QWF2 TIM-barrel protein, nifR3 family n=26 Tax=Bacteroidetes/Chlorobi group RepID=B3QWF2_CHLT3 Length = 402 Score = 151 bits (382), Expect = 4e-35, Method: Composition-based stats. Identities = 47/257 (18%), Positives = 94/257 (36%), Gaps = 36/257 (14%) Query: 42 GGVVF-KTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP 100 G + K + +V+ + + G ++ + + + R+L Sbjct: 48 GQIEIEKPVILAPMEDVTDPSFRRLCKHYGADIVFTEFISSDGLIRHAVKSKRKLDVFDD 107 Query: 101 DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEK 158 ++ + I G + E A++ + AG D I+ N+ CP ++ GS + P+L+EK Sbjct: 108 ERPVAIQIFGNQIEPMVEAAQMAEAAGPDFIDINYGCPAKKVAGKGAGSGLLCQPDLMEK 167 Query: 159 YCRAVKRGSTLPMLAKMTPNIGD----MCEVALAAKRGGADGIAAINTVKSITNIDLNQK 214 AV + LP+ AK + + + + G ++ Sbjct: 168 ITDAVVKAVRLPVTAKTRIGWDERSISILDTVRRLEGCGIQALS---------------- 211 Query: 215 IGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL-L 273 ++G++ Y G+A +I + + E+ PI G G I T EDA Sbjct: 212 -----IHGRTRAQMYKGRAD----WSWIARAK---EVATIPIIGNGDIWTAEDAKRMFDE 259 Query: 274 LGAATLQVTTGIMQYGY 290 G + + G + + Sbjct: 260 TGVDGVMIGRGAIGNPF 276 >UniRef50_Q1IVR5 Dihydrouridine synthase TIM-barrel protein nifR3 n=2 Tax=Acidobacteria RepID=Q1IVR5_ACIBL Length = 370 Score = 151 bits (380), Expect = 6e-35, Method: Composition-based stats. Identities = 54/307 (17%), Positives = 100/307 (32%), Gaps = 45/307 (14%) Query: 15 FPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIG-FFIANEVSPRFDHLVKEDTGFIG 73 F NP E A G V + V+ + G G Sbjct: 5 FDNPI------QHQAPEGACVAVRFQIGSVEIRPATVLAPMAGVTDTVFRRFIRNLGGCG 58 Query: 74 FKNMEQIAEHPLEEN--LAALRRLKEDYPDKVLIASIMGENEQQWEELARLVQEAGADMI 131 E + L A R L ++ + A + G + + + A++VQ+ G D++ Sbjct: 59 LMMTEFTSADGLARMREAKARRYLTFYGNERPISAQLFGSDAETLADAAKVVQDLGFDLV 118 Query: 132 ECNFSCPQ--MTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMTPNIGD----MCEV 185 + N CP + GS + + ++ +V++ T+P K + E+ Sbjct: 119 DLNLGCPSKRVVKCNGGSGLLRDLPQIKVIFESVRKAVTIPFTVKFRAGWNEKELVFLEL 178 Query: 186 ALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKAVKPIALRFIQQM 245 A A+ G + +A + ++ GYSG+A +I + Sbjct: 179 AKLAENCGLNAVAM---------------------HARTREQGYSGQAN----WGWIADL 213 Query: 246 RTHPELRDFPISGIGGIETWEDAAEFL-LLGAATLQVTTGIMQYGYRIVEDMASGLSHYL 304 + + P+ G G I T EDAA + G + + I + + Sbjct: 214 KQVVK---IPVIGNGDIRTPEDAAAMVAKTGCDAVMIGRSAASN-PWIFRQIEQYTATGR 269 Query: 305 ADQGFDS 311 D + Sbjct: 270 YDLPTNE 276 >UniRef50_B8GCQ5 TIM-barrel protein, nifR3 family n=6 Tax=Chloroflexi (class) RepID=B8GCQ5_CHLAD Length = 351 Score = 151 bits (380), Expect = 6e-35, Method: Composition-based stats. Identities = 51/255 (20%), Positives = 91/255 (35%), Gaps = 31/255 (12%) Query: 49 IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLE-ENLAALRRLKEDYPDKVLIAS 107 I V+ + G G + E + + L R L ++ L Sbjct: 28 IVLAPMAGVTDSIFRRMILRLGGCGLVSTEMTNAASVSPKALRRHRLLDYLPEERPLTMQ 87 Query: 108 IMGENEQQWEELARLVQEAGADMIECNFSC--PQMTSHAMGSDVGQSPELVEKYCRAVKR 165 I G + AR+V++ GAD+I+ N C P++T GS + + +E+ RAV+ Sbjct: 88 ISGNDPDLVANAARVVEQLGADIIDINCGCPSPKVTGGGHGSALLRDLPKMERLLRAVRA 147 Query: 166 GSTLPMLAKMTPNIGDM-CEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKS 224 +P+ K+ + A +R A G+AA ++ ++ Sbjct: 148 AVQIPVTLKLRAGWDEASLNFIEAGQRAEAAGVAA------------------LTLHPRT 189 Query: 225 SISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDA-AEFLLLGAATLQVTT 283 GY G+A ++ P+ G G + T +DA GA + + Sbjct: 190 REQGYKGQADW-------SRVAALKRAVSIPVIGSGDVVTAQDALIRLRDSGADGVMIGR 242 Query: 284 GIMQYGYRIVEDMAS 298 G + I +A Sbjct: 243 GAIAN-PWIFRQVAD 256 >UniRef50_C3MBL4 tRNA-dihydrouridine synthase n=1 Tax=Rhizobium sp. NGR234 RepID=C3MBL4_RHISN Length = 342 Score = 149 bits (376), Expect = 2e-34, Method: Composition-based stats. Identities = 48/257 (18%), Positives = 91/257 (35%), Gaps = 37/257 (14%) Query: 42 GGVVFKT-IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYP 100 G V + + + V+ ++ G GF E +A L N A ++ Sbjct: 20 GNVEIRNRVALAPMSGVTDLPFRMLAWRFGA-GFVVTEMVASRELVGNAAESWARLKNSG 78 Query: 101 DKVLIASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEK 158 I + G E A++V+ GAD+++ N CP ++T GS + + P+ Sbjct: 79 IDPHIVQLAGREAHWMAEAAKIVEANGADIVDINMGCPAKKVTGGYSGSALMRDPDHALS 138 Query: 159 YCRAVKRGSTLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQK 214 A + +P+ KM + +A A+ G I Sbjct: 139 LIEATVKAVRVPVTLKMRLGWDENSINAPLIARRAEEAGVQAIT---------------- 182 Query: 215 IGMPIVNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEF-LL 273 ++G++ + Y+G A A+R ++ + P+ G ++T DA E Sbjct: 183 -----IHGRTRMQFYNGNADWD-AIRAVRDV------ISIPLIANGDVDTIADAMEILRR 230 Query: 274 LGAATLQVTTGIMQYGY 290 GA + + + Sbjct: 231 SGADAVMLGRSCQGRPW 247 >UniRef50_A0LJ96 Putative TIM-barrel protein, nifR3 family n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LJ96_SYNFM Length = 352 Score = 148 bits (373), Expect = 5e-34, Method: Composition-based stats. Identities = 46/294 (15%), Positives = 94/294 (31%), Gaps = 39/294 (13%) Query: 52 FIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRL--KEDYPDKVLIASIM 109 V+ + D G E ++ L N A L ++ L + Sbjct: 27 APMAGVTDSAYRALMADFGA-AMVTTEMVSIQGLVRNQRATLDLCRQQHPVGVPLAVQVF 85 Query: 110 GENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRGS 167 G + E ARLV++ GA +I+ N CP ++ G+ + + P+ + AVKR Sbjct: 86 GRDPAVMAEAARLVEQGGAALIDINAGCPVRKVVRQGAGAILLKDPDRLAAMVEAVKRAV 145 Query: 168 TLPMLAKMTPNIGDMCE----VALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGK 223 ++P+ K+ + +A G D I V+G+ Sbjct: 146 SVPVTVKIRVGWDNAANGVAGLARQLVSAGVDAIT---------------------VHGR 184 Query: 224 SSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL-LLGAATLQVT 282 ++ YSG+A ++ P+ G G + + E A + G + + Sbjct: 185 TAAQMYSGRADW-------SRIAEVKAAVAVPVIGNGDVTSPELAERMIHETGCDGVMIG 237 Query: 283 TGIMQYGYRIVEDMASGLSHYLADQGFDSLQEMVGLANNNIVPAEDLDRSYIVY 336 + + ++ + + A ++ + + Sbjct: 238 RASLGN-PWLFAVISRRWGRGARQGDCPGWNDFLRTAEAHLESFRTMRPRADGH 290 >UniRef50_Q31II6 Dihydrouridine synthase n=1 Tax=Thiomicrospira crunogena XCL-2 RepID=Q31II6_THICR Length = 320 Score = 147 bits (372), Expect = 5e-34, Method: Composition-based stats. Identities = 44/260 (16%), Positives = 93/260 (35%), Gaps = 36/260 (13%) Query: 46 FKTIGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLI 105 TI ++ R + ++G + ++ L E+ + R + I Sbjct: 9 TPTIALAPMAGITDRVYRDICRESGASYAVSEMVASKKQLRESAKSSTRHADKTETSPRI 68 Query: 106 ASIMGENEQQWEELARLVQEAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAV 163 ++G + ++ + A Q GAD+I+ N CP ++ A GS + PE V +++ Sbjct: 69 VQLLGTHPEELVDAALWQQSQGADIIDLNMGCPAKKVCDVAAGSALMGQPERVADIFKSL 128 Query: 164 KRGSTLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 LP+ K+ + E+A A+ G I Sbjct: 129 TEAIDLPVTVKIRTGTDVDNINAVEIAKLAQELGLKAIT--------------------- 167 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAE-FLLLGAAT 278 ++G++ ++G+A ++ + D P+ G I + ++A G+ Sbjct: 168 IHGRTRADKFNGQAEYD-------TIKAVKQAVDIPVIANGDICSPKEAQFVLKYTGSDG 220 Query: 279 LQVTTGIMQYGYRIVEDMAS 298 + + Y I ++A Sbjct: 221 IMIGRAAQGY-PWIFREIAH 239 >UniRef50_Q5M689 Possible transcriptional regulator n=25 Tax=Streptococcus RepID=Q5M689_STRT2 Length = 350 Score = 147 bits (371), Expect = 6e-34, Method: Composition-based stats. Identities = 56/309 (18%), Positives = 104/309 (33%), Gaps = 52/309 (16%) Query: 3 TKDLSITFCGVKFPNPFC--LSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANEVSPR 60 + LS+ F + + N L+SS + E+ + T+ V+ Sbjct: 9 SAKLSMNFQKLTWRNSSMTKLNSSFMIGNVEIPHR------------TV-LAPMAGVTNS 55 Query: 61 FDHLVKEDTGFIGFKNMEQIAEHPLEEN-LAALRRLKEDYPDKVLIASIMGENEQQWEEL 119 + ++ G ME I+E L N L L D + + + G + + + Sbjct: 56 AFRTIAKEFSA-GLVVMEMISEKGLLYNNEKTLHMLHIDENEHPMSIQLFGGDAEGLKRA 114 Query: 120 ARLVQ-EAGADMIECNFSCP--QMTSHAMGSDVGQSPELVEKYCRAVKRGSTLPMLAKMT 176 A +Q AD+++ N CP ++ + G+ + P+ + + V +P+ KM Sbjct: 115 ADFIQTNTKADIVDINMGCPVNKVVKNEAGAKWLKDPDKIYHIVKEVTSVLDIPLTVKMR 174 Query: 177 PNIGD---MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSSISGYSGKA 233 D E ALAA+ G +A +G++ Y+G Sbjct: 175 TGWSDSDLAVENALAAESAGVSALAM---------------------HGRTREQMYTGHC 213 Query: 234 VKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFL-LLGAATLQVTTGIMQYGYRI 292 + ++ P G G + +DA + LG + V M Y I Sbjct: 214 DHET----LARVAKAI--TKIPFIGNGDVRNVQDAKLMIEELGVDAVMVGRAAMNNPY-I 266 Query: 293 VEDMASGLS 301 + Sbjct: 267 FTQINHFFE 275 >UniRef50_A9NE09 tRNA-dihydrouridine synthase n=2 Tax=Mollicutes RepID=A9NE09_ACHLI Length = 336 Score = 147 bits (370), Expect = 1e-33, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 87/262 (33%), Gaps = 40/262 (15%) Query: 49 IGFFIANEVSPRFDHLVKEDTGFIGFKNMEQIAEHPLE-ENLAALRRLKEDYPDKVLIAS 107 + VS L+ G G E +++ + +N L+ L +K Sbjct: 14 LILAPMAGVSNHPFRLMARQLGA-GVVFAEMVSDKAIFFQNPKTLQMLYMTVEEKPAAQQ 72 Query: 108 IMGENEQQWEELARLVQ-EAGADMIECNFSCPQMT---SHAMGSDVGQSPELVEKYCRAV 163 I G + + E A + + D I+ N CP G+ + + P+ + +A+ Sbjct: 73 IFGSDLETMVEAAMFIDKNSNCDFIDINMGCPVPKVAIGAQAGASLMKDPQKIYDIVKAI 132 Query: 164 KRGSTLPMLAKMTPNIG----DMCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPI 219 K + P+ K+ + EVA ++ GA I Sbjct: 133 KEKVSKPVTVKIRSGWDSESVNAVEVAKMIEKAGASLIT--------------------- 171 Query: 220 VNGKSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEF-LLLGAAT 278 V+ ++ GYSG+ + ++ E P+ G G I + A G Sbjct: 172 VHARTRAQGYSGEPDLDV-------IKAVKEAVSIPVIGNGNIVDGKSAKHMLEYTGCDA 224 Query: 279 LQVTTGIMQYGYRIVEDMASGL 300 + + + I ++ + L Sbjct: 225 VMIGRASLGN-PWIFREINAYL 245 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.313 0.132 0.384 Lambda K H 0.267 0.0401 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,280,553,035 Number of Sequences: 3077464 Number of extensions: 91045890 Number of successful extensions: 397418 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 3757 Number of HSP's successfully gapped in prelim test: 6490 Number of HSP's that attempted gapping in prelim test: 360384 Number of HSP's gapped (non-prelim): 24973 length of query: 411 length of database: 1,040,396,356 effective HSP length: 131 effective length of query: 280 effective length of database: 637,248,572 effective search space: 178429600160 effective search space used: 178429600160 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 94 (40.9 bits)