Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	H	K	A	T	E	I	L	T	G	K	V	M	Q	K	S	V	L	I	T	G	C	S	S	G	I	G	L	E	S	A	L	E	L	K	R	Q	G	F	H	V	L	A	G	C	R	K	P	D	D	V	E	R	M	N	S	M	G	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	G	V	L	I	D	L	D	S	P	E	S	V	D	R	A	A	D	E	V	I	A	L	T	D	N	C	L	Y	G	I	F	N	N	A	G	F	G	M	Y	G	P	L	S	T	I	S	R	A	Q	M	E	Q	Q	F	S	A	N	F	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	H	Q	L	T	M	R	L	L	P	A	M	L	P	H	G	E	G	R	I	V	M	T	S	S	V	M	G	L	I	S	T	P	G	R	G	A	Y	A	A	S	K	Y	A	L	E	A	W	S	D	A	L	R	M	E	L	R	H	S
Secondary structure
SS confidence
Disorder																													?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	I	K	V	S	L	I	E	P	G	P	I	R	T	R	F	T	D	N	V	N	Q	T	Q	S	D	K	P	V	E	N	P	G	I	A	A	R	F	T	L	G	P	E	A	V	V	D	K	V	R	H	A	F	I	S	E	K	P	K	M
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.
Sequence		R	Y	P	V	T	L	V	T	W	A	V	M	V	L	K	R	L	L	P	G	R	V	M	D	K	I	L	Q	G
Secondary structure
SS confidence
Disorder																													?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1xu9 chain A Region: 10 - 268 Aligned: 245 Modelled: 249 Confidence: 100.0% Identity: 21% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 1xse chain A Region: 9 - 268 Aligned: 246 Modelled: 260 Confidence: 100.0% Identity: 21% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 1y5m chain A domain 1 Region: 10 - 268 Aligned: 245 Modelled: 259 Confidence: 100.0% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 1fdv chain A Region: 14 - 259 Aligned: 246 Modelled: 246 Confidence: 100.0% Identity: 29% PDB header:dehydrogenase Chain: A: PDB Molecule:17-beta-hydroxysteroid dehydrogenase; PDBTitle: human 17-beta-hydroxysteroid-dehydrogenase type 1 mutant2 h221l complexed with nad+ Phyre2 PDB 3tjr chain A Region: 9 - 269 Aligned: 246 Modelled: 247 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:short chain dehydrogenase; PDBTitle: crystal structure of a rv0851c ortholog short chain dehydrogenase from2 mycobacterium paratuberculosis Phyre2 PDB 1jtv chain A Region: 14 - 268 Aligned: 255 Modelled: 255 Confidence: 100.0% Identity: 27% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 1iy8 chain A Region: 12 - 233 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 3svt chain A Region: 13 - 233 Aligned: 221 Modelled: 221 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:short-chain type dehydrogenase/reductase; PDBTitle: structure of a short-chain type dehydrogenase/reductase from2 mycobacterium ulcerans Phyre2 PDB 1gee chain A Region: 9 - 233 Aligned: 225 Modelled: 225 Confidence: 100.0% Identity: 19% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 3lf2 chain B Region: 10 - 233 Aligned: 224 Modelled: 224 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: B: PDB Molecule:short chain oxidoreductase q9hya2; PDBTitle: nadph bound structure of the short chain oxidoreductase q9hya2 from2 pseudomonas aeruginosa pao1 containing an atypical catalytic center Phyre2 PDB 2ae2 chain A Region: 10 - 233 Aligned: 224 Modelled: 224 Confidence: 100.0% Identity: 24% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 3rku chain C Region: 10 - 238 Aligned: 227 Modelled: 229 Confidence: 100.0% Identity: 24% PDB header:oxidoreductase Chain: C: PDB Molecule:oxidoreductase ymr226c; PDBTitle: substrate fingerprint and the structure of nadp+ dependent serine2 dehydrogenase from saccharomyces cerevisiae complexed with nadp+ Phyre2 PDB 2bel chain A Region: 10 - 251 Aligned: 231 Modelled: 242 Confidence: 100.0% Identity: 23% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 2zat chain C Region: 12 - 233 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: C: PDB Molecule:dehydrogenase/reductase sdr family member 4; PDBTitle: crystal structure of a mammalian reductase Phyre2 PDB 1xhl chain A Region: 12 - 233 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 20% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 3p19 chain A Region: 14 - 237 Aligned: 223 Modelled: 224 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:putative blue fluorescent protein; PDBTitle: improved nadph-dependent blue fluorescent protein Phyre2 PDB 1zem chain A domain 1 Region: 12 - 233 Aligned: 222 Modelled: 222 Confidence: 100.0% Identity: 23% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 3nug chain A Region: 10 - 233 Aligned: 223 Modelled: 224 Confidence: 100.0% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:3-oxoacyl-(acyl-carrier protein) reductase; PDBTitle: crystal structure of wild type tetrameric pyridoxal 4-dehydrogenase2 from mesorhizobium loti Phyre2 PDB 1yxm chain A domain 1 Region: 3 - 233 Aligned: 228 Modelled: 231 Confidence: 100.0% Identity: 18% Fold: NAD(P)-binding Rossmann-fold domains Superfamily: NAD(P)-binding Rossmann-fold domains Family: Tyrosine-dependent oxidoreductases Phyre2 PDB 2p68 chain A Region: 9 - 233 Aligned: 223 Modelled: 225 Confidence: 100.0% Identity: 25% PDB header:oxidoreductase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] reductase; PDBTitle: crystal structure of aq_1716 from aquifex aeolicus vf5 Phyre2 1 d1xu9a_ 2 d1xsea_ 3 d1y5ma1 4 c1fdvA_ 5 c3tjrA_ 6 d1jtva_ 7 d1iy8a_ 8 c3svtA_ 9 d1geea_ 10 c3lf2B_ 11 d2ae2a_ 12 c3rkuC_ 13 d2bela_ 14 c2zatC_ 15 d1xhla_ 16 c3p19A_ 17 d1zema1 18 c3nugA_ 19 d1yxma1 20 c2p68A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499