BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (237 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_A7ZPS1 Phosphoribosylaminoimidazole-succinocarboxamide ...   484   e-135
UniRef50_C8PXT0 Phosphoribosylaminoimidazole-succinocarboxamide ...   321   1e-86
UniRef50_Q8D2M4 Phosphoribosylaminoimidazole-succinocarboxamide ...   248   8e-65
UniRef50_C2D8C6 Phosphoribosylaminoimidazolesuccinocarboxamide s...   208   1e-52
UniRef50_C9M8K7 Phosphoribosylaminoimidazole-succinocarboxamide ...   201   2e-50
UniRef50_Q049L4 Phosphoribosylaminoimidazole-succinocarboxamide ...   200   3e-50
UniRef50_Q2NCK7 Phosphoribosylaminoimidazole-succinocarboxamide ...   200   4e-50
UniRef50_B1YJ02 Phosphoribosylaminoimidazole-succinocarboxamide ...   199   5e-50
UniRef50_Q2GHH2 Phosphoribosylaminoimidazole-succinocarboxamide ...   198   1e-49
UniRef50_A9VRE8 Phosphoribosylaminoimidazole-succinocarboxamide ...   197   2e-49
UniRef50_Q38XX0 Phosphoribosylaminoimidazole-succinocarboxamide ...   197   3e-49
UniRef50_B9EAY5 Phosphoribosylaminoimidazole-succinocarboxamide ...   189   7e-47
UniRef50_B8DTV0 Phosphoribosylaminoimidazole-succinocarboxamide ...   189   7e-47
UniRef50_A7X0V7 Phosphoribosylaminoimidazole-succinocarboxamide ...   187   2e-46
UniRef50_A0AJM6 Phosphoribosylaminoimidazole-succinocarboxamide ...   186   6e-46
UniRef50_Q8TX83 Phosphoribosylaminoimidazole-succinocarboxamide ...   186   7e-46
UniRef50_B5IMM2 Phosphoribosylaminoimidazole-succinocarboxamide ...   186   8e-46
UniRef50_Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide ...   185   1e-45
UniRef50_O57978 Phosphoribosylaminoimidazole-succinocarboxamide ...   185   1e-45
UniRef50_A4SE69 Phosphoribosylaminoimidazole-succinocarboxamide ...   184   2e-45
UniRef50_A6Q3C7 Phosphoribosylaminoimidazole-succinocarboxamide ...   184   3e-45
UniRef50_O26272 Phosphoribosylaminoimidazole-succinocarboxamide ...   184   3e-45
UniRef50_C6I122 Phosphoribosylaminoimidazole-succinocarboxamide ...   181   3e-44
UniRef50_D0JBF3 Phosphoribosylaminoimidazole-succinocarboxamide ...   179   8e-44
UniRef50_A4FYT6 Phosphoribosylaminoimidazole-succinocarboxamide ...   178   1e-43
UniRef50_Q3AHS3 Phosphoribosylaminoimidazole-succinocarboxamide ...   175   9e-43
UniRef50_Q1AXB9 Phosphoribosylaminoimidazole-succinocarboxamide ...   174   3e-42
UniRef50_Q7V0C7 Phosphoribosylaminoimidazole-succinocarboxamide ...   172   1e-41
UniRef50_P73471 Phosphoribosylaminoimidazole-succinocarboxamide ...   169   1e-40
UniRef50_A9BIH1 Phosphoribosylaminoimidazole-succinocarboxamide ...   159   1e-37
UniRef50_B8D414 Phosphoribosylaminoimidazolesuccinocarboxamide s...   155   9e-37
UniRef50_Q03E76 Phosphoribosylaminoimidazole-succinocarboxamide ...   152   1e-35
UniRef50_D2EKX6 Phosphoribosylaminoimidazole-succinocarboxamide ...   151   1e-35
UniRef50_C6XGE3 Phosphoribosylaminoimidazole-succinocarboxamide ...   148   1e-34
UniRef50_Q4J8G0 Phosphoribosylaminoimidazole-succinocarboxamide ...   146   5e-34
UniRef50_Q03Y92 Phosphoribosylaminoimidazole-succinocarboxamide ...   145   1e-33
UniRef50_C2U7A6 Phosphoribosylaminoimidazole-succinocarboxamide ...   143   4e-33
UniRef50_A8AAS3 Phosphoribosylaminoimidazole-succinocarboxamide ...   141   2e-32
UniRef50_B1LCA5 Phosphoribosylaminoimidazole-succinocarboxamide ...   139   6e-32
UniRef50_A8MCJ8 Phosphoribosylaminoimidazole-succinocarboxamide ...   137   3e-31
UniRef50_A8GML2 Phosphoribosylaminoimidazole-succinocarboxamide ...   122   9e-27
UniRef50_A5CCM2 Phosphoribosylaminoimidazole-succinocarboxamides...   112   9e-24
UniRef50_P22234 Phosphoribosylaminoimidazole carboxylase n=88 Ta...   112   1e-23
UniRef50_Q648Z8 Phosphoribosylaminoimidazolesuccinocarboxamide s...   110   4e-23
UniRef50_A3MXE4 Phosphoribosylaminoimidazole-succinocarboxamide ...   109   8e-23
UniRef50_A9A5G9 Phosphoribosylaminoimidazole-succinocarboxamide ...   105   2e-21
UniRef50_B8GCM2 Phosphoribosylaminoimidazole-succinocarboxamide ...    99   1e-19
UniRef50_UPI00006A4774 PREDICTED: similar to phosphoribosylamino...    96   7e-19
UniRef50_A9VBB9 Phosphoribosylaminoimidazole-succinocarboxamide ...    92   1e-17
UniRef50_B3V647 Phosphoribosylaminoimidazole-succinocarboxamide ...    91   2e-17
UniRef50_B4Q3U0 GD23841 n=2 Tax=melanogaster subgroup RepID=B4Q3...    86   1e-15
UniRef50_Q9VK80 CG17024 n=4 Tax=melanogaster group RepID=Q9VK80_...    80   4e-14
UniRef50_B2A872 Phosphoribosylaminoimidazole-succinocarboxamide ...    80   5e-14
UniRef50_Q72UH8 Phosphoribosylaminoimidazole-succinocarboxamide ...    79   2e-13
UniRef50_C1A3U9 Phosphoribosylaminoimidazole-succinocarboxamide ...    76   1e-12
UniRef50_C7RD67 Phosphoribosylaminoimidazole-succinocarboxamide ...    75   2e-12
UniRef50_C5A6A8 Phosphoribosylaminoimidazole-succinocarboxamide ...    73   7e-12
UniRef50_C6CV28 Phosphoribosylaminoimidazolesuccinocarboxamide s...    73   8e-12
UniRef50_Q47KH4 Phosphoribosylaminoimidazole-succinocarboxamide ...    72   1e-11
UniRef50_Q9P9D8 SAICAR synthase n=1 Tax=uncultured marine group ...    72   2e-11
UniRef50_Q67KF6 Phosphoribosylaminoimidazole-succinocarboxamide ...    71   3e-11
UniRef50_B2KCE9 Phosphoribosylaminoimidazole-succinocarboxamide ...    69   1e-10
UniRef50_C6BVA6 Phosphoribosylaminoimidazole-succinocarboxamide ...    69   2e-10
UniRef50_B5GT63 Phosphoribosylaminoimidazole-succinocarboxamide ...    69   2e-10
UniRef50_UPI0001926A10 PREDICTED: similar to phosphoribosylamino...    69   2e-10
UniRef50_B3DVV2 Phosphoribosylaminoimidazolesuccinocarboxamide (...    67   5e-10
UniRef50_C4FB69 Phosphoribosylaminoimidazole-succinocarboxamide ...    67   5e-10
UniRef50_Q313T8 Phosphoribosylaminoimidazole-succinocarboxamide ...    66   8e-10
UniRef50_B0VH32 Phosphoribosylaminoimidazole-succinocarboxamide ...    63   7e-09
UniRef50_A8ZVI6 Phosphoribosylaminoimidazole-succinocarboxamide ...    62   2e-08
UniRef50_B8J393 Phosphoribosylaminoimidazolesuccinocarboxamide s...    61   3e-08
UniRef50_A7H9G3 Phosphoribosylaminoimidazolesuccinocarboxamide s...    61   3e-08
UniRef50_Q3Z881 Phosphoribosylaminoimidazole-succinocarboxamide ...    61   3e-08
UniRef50_Q895U7 Phosphoribosylaminoimidazole-succinocarboxamide ...    60   4e-08
UniRef50_A8M140 SAICAR synthetase n=1 Tax=Salinispora arenicola ...    59   1e-07
UniRef50_C7M1W2 Phosphoribosylaminoimidazolesuccinocarboxamide s...    59   2e-07
UniRef50_Q466M0 Phosphoribosylaminoimidazole-succinocarboxamide ...    58   2e-07
UniRef50_Q5X4M9 Phosphoribosylaminoimidazole-succinocarboxamide ...    58   2e-07
UniRef50_A1VU36 Phosphoribosylaminoimidazole-succinocarboxamide ...    57   4e-07
UniRef50_Q7UJ19 Phosphoribosylaminoimidazole-succinocarboxamide ...    57   4e-07
UniRef50_B5JQ22 Phosphoribosylaminoimidazole-succinocarboxamide ...    57   4e-07
UniRef50_Q3CXY3 Phosphoribosylaminoimidazole-succinocarboxamide ...    57   5e-07
UniRef50_P27616 Phosphoribosylaminoimidazole-succinocarboxamide ...    57   6e-07
UniRef50_Q9HLC0 Phosphoribosylaminoimidazole-succinocarboxamide ...    56   1e-06
UniRef50_C7NLA9 Phosphoribosylaminoimidazole-succinocarboxamide ...    55   2e-06
UniRef50_B3T553 Putative SAICAR synthetase n=2 Tax=prokaryotic e...    55   2e-06
UniRef50_B5GV74 Saicar synthetase n=1 Tax=Streptomyces clavulige...    54   3e-06
UniRef50_D0MIB5 Phosphoribosylaminoimidazolesuccinocarboxamidesy...    54   3e-06
UniRef50_A7BA15 Phosphoribosylaminoimidazole-succinocarboxamide ...    54   4e-06
UniRef50_Q9UUB4 Phosphoribosylaminoimidazole-succinocarboxamide ...    54   6e-06
UniRef50_Q83GX1 Phosphoribosylaminoimidazole-succinocarboxamide ...    53   8e-06
UniRef50_UPI000187DCD8 hypothetical protein MPER_11578 n=1 Tax=M...    53   9e-06
UniRef50_A6LDF8 Phosphoribosylamidoimidazole-succinocarboxamide ...    52   1e-05
UniRef50_C9KPE2 Phosphoribosylaminoimidazole-succinocarboxamide ...    52   1e-05
UniRef50_UPI00015FF598 UPI00015FF598 related cluster n=1 Tax=Dro...    52   2e-05
UniRef50_A8LCN0 Phosphoribosylaminoimidazole-succinocarboxamide ...    52   2e-05
UniRef50_UPI000038E095 phosphoribosylaminoimidazole-succinocarbo...    51   4e-05
UniRef50_Q5P7J7 Phosphoribosylaminoimidazole-succinocarboxamide ...    50   5e-05
UniRef50_A6GYJ4 Phosphoribosylaminoimidazole-succinocarboxamide ...    50   5e-05
UniRef50_Q11TT6 Phosphoribosylaminoimidazole-succinocarboxamide ...    50   7e-05
UniRef50_B7FS23 Phosphoribosylaminoimidazole-succinocarboxamide ...    50   8e-05
UniRef50_D0LZ80 Phosphoribosylaminoimidazolesuccinocarboxamidesy...    49   2e-04
UniRef50_B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide ...    48   2e-04
UniRef50_Q6NRP1 LOC431975 protein (Fragment) n=2 Tax=Xenopus Rep...    48   3e-04
UniRef50_Q73PW0 Phosphoribosylaminoimidazole-succinocarboxamide ...    46   0.001
UniRef50_Q978V1 Phosphoribosylaminoimidazole-succinocarboxamide ...    45   0.002
UniRef50_B3G3Y1 Saicars n=1 Tax=Adineta vaga RepID=B3G3Y1_ADIVA        45   0.002
UniRef50_B8IQA8 Phosphoribosylaminoimidazole-succinocarboxamide ...    44   0.005
UniRef50_Q8UCE7 Putative phosphoribosylaminoimidazole-succinocar...    43   0.007
UniRef50_Q94IQ2 Phosphoribosylaminoimidazole-succinocarboxamide ...    41   0.027
UniRef50_A4SAQ9 Phosphoribosylaminoimidazole-succinocarboxamide ...    41   0.030
UniRef50_Q46F31 Putative uncharacterized protein n=1 Tax=Methano...    40   0.046

>UniRef50_A7ZPS1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=182
           Tax=Gammaproteobacteria RepID=PUR7_ECO24
          Length = 237

 Score =  484 bits (1246), Expect = e-135,   Method: Compositional matrix adjust.
 Identities = 237/237 (100%), Positives = 237/237 (100%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK
Sbjct: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL
Sbjct: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF
Sbjct: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD 237
           GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
Sbjct: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD 237


>UniRef50_C8PXT0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Gammaproteobacteria RepID=C8PXT0_9GAMM
          Length = 242

 Score =  321 bits (823), Expect = 1e-86,   Method: Compositional matrix adjust.
 Identities = 152/236 (64%), Positives = 188/236 (79%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK   LY+GKAK+V+ T+NPD L+LEFR+DTSA +G RIEQ  RKG VNN+FN FIM K
Sbjct: 1   MQKLDLLYKGKAKSVFETDNPDYLILEFRDDTSAFNGERIEQLARKGKVNNRFNAFIMQK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L+EAGI T  E+ LSD E LVK+L M+PVECVVRN AAGSLV+RLG++EG  L PP F+L
Sbjct: 61  LSEAGIETHFEQQLSDEEVLVKRLTMIPVECVVRNYAAGSLVRRLGLQEGQALTPPTFEL 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DPMVN+S   + GW ++  L  MK LT+K NDVL K+FDD GL+LVDFKLEF
Sbjct: 121 FYKDDGLGDPMVNDSLAVSLGWATQAQLDEMKALTFKVNDVLSKMFDDGGLMLVDFKLEF 180

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQL 236
           G++K  +VLGDEFSPDG R+WDK+T +K+DKDRFRQSLG ++E YE VA+R+GV L
Sbjct: 181 GVFKDRIVLGDEFSPDGCRVWDKQTKKKLDKDRFRQSLGDVVEGYEEVAKRIGVSL 236


>UniRef50_Q8D2M4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=46
           Tax=Gammaproteobacteria RepID=PUR7_WIGBR
          Length = 240

 Score =  248 bits (634), Expect = 8e-65,   Method: Compositional matrix adjust.
 Identities = 118/238 (49%), Positives = 176/238 (73%), Gaps = 1/238 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           ++K+ ++Y+GK+K +YST N D+L+L+F+ D S  +G  I++FD K ++NNKFNY+IM+K
Sbjct: 3   IKKKNKIYQGKSKIIYSTNNSDVLILKFKKDMSRLNGKYIKKFDNKDIINNKFNYYIMNK 62

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           ++   I T +  LLSD + +VKKL M+P+E VVRN A GSL+KR  I+E   +NPP+ + 
Sbjct: 63  ISSFNIKTHILSLLSDNQVIVKKLKMIPIEFVVRNYAYGSLLKRFLIKERSFINPPILEF 122

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F KND + DPM+NE +C +F  +S+ ++ ++K++ YK N++LK +F  A LILVDFKLEF
Sbjct: 123 FFKNDGLKDPMINEYHCISFNLISENHIKKIKKILYKINNILKDIFYKAELILVDFKLEF 182

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLG-GLIEAYEAVARRLGVQLD 237
           GL+ G++ LGDEFS D SR+WDK + +KMDKD FR+ L   +IE+Y+ VA R+G  +D
Sbjct: 183 GLFNGDLFLGDEFSLDNSRVWDKNSFKKMDKDIFREQLNENVIESYKEVANRIGCLID 240


>UniRef50_C2D8C6 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Atopobium vaginae DSM 15829 RepID=C2D8C6_9ACTN
          Length = 238

 Score =  208 bits (529), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 112/233 (48%), Positives = 150/233 (64%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK    Y GKAK +Y T++P LL + +++  +AGDGA+ EQ   KG +N K    I + 
Sbjct: 1   MQKGKLSYVGKAKDMYETDDPRLLWMVYKDQATAGDGAKKEQIAGKGELNQKITRLIFAY 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           LA+ GI T +++++SDTE LV+KLDM  +E V+RN AAGS+V+RLGIE+G E    + + 
Sbjct: 61  LADHGIKTHLKKIISDTEELVEKLDMFELEVVLRNLAAGSIVRRLGIEKGTEFKGGMIEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D +HDP++ +         +   L  +K LT + N +L +LF  AGLILVDFKLEF
Sbjct: 121 YYKSDDLHDPLLTDDNLMFMHLATPAQLQEIKRLTLEVNTLLTELFKRAGLILVDFKLEF 180

Query: 181 GL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    GEVVLGDEFSPD  RLWD  T E  DKD FR S   +I  Y+AV  RL
Sbjct: 181 GTNADGEVVLGDEFSPDNCRLWDVHTHESFDKDIFRNSDEDMIPFYKAVYERL 233


>UniRef50_C9M8K7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Jonquetella anthropi E3_33 E1 RepID=C9M8K7_9BACT
          Length = 251

 Score =  201 bits (510), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 91/230 (39%), Positives = 156/230 (67%), Gaps = 1/230 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK ++ST++P++L++++++  +A +  + ++   KG +NN  + +I + LA+ G+
Sbjct: 18  LYEGKAKKIFSTDDPNVLLVQYKDSLTAFNAKKRDEKAGKGHLNNVISSWIFTWLAKKGV 77

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
            +   + + +T  L++K++++P+E +VRN   GSL +RLG+EEG +L+ P+ +   K+DA
Sbjct: 78  ESHFIKQVDETHQLIRKVEIIPLETIVRNVTTGSLCRRLGVEEGKKLSRPIIEFSYKSDA 137

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKG 185
           + DP++N+ +    GW ++E +A +K +  K N +L +LF   G++LVDFKLEFG   KG
Sbjct: 138 LDDPLINDDHAIVLGWATEEEVATIKSIALKVNKLLTELFASVGVLLVDFKLEFGRDEKG 197

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
            V+L DE SPD  R WD +T + +DKDRFR+ LG ++ AYE + RRL  +
Sbjct: 198 RVLLADEISPDTCRFWDSKTHDHLDKDRFRKDLGDVLGAYEEIWRRLSAR 247


>UniRef50_Q049L4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Lactobacillus delbrueckii subsp. bulgaricus
           RepID=Q049L4_LACDB
          Length = 240

 Score =  200 bits (509), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 103/228 (45%), Positives = 154/228 (67%), Gaps = 2/228 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY+GK K +++T++P++L   +++D +A DG + + F  KG ++ + +  +   L + G+
Sbjct: 5   LYQGKTKEMWTTDDPEVLRAVYKDDATALDGLKHDVFQNKGELDAEISSLVFEYLMKHGV 64

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFDLFLKND 125
            T   + LS  E LVKK+ M+ +E V RN AAGS  KR G+ EEG +L+ P+ +LF+K+D
Sbjct: 65  KTHFIKRLSKNEQLVKKVKMIDLEVVTRNIAAGSFCKRYGLKEEGEKLDTPVEELFMKSD 124

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG-LYK 184
           A+HDP++NES    F  ++ E   ++ E++ + N +L KLF DAG++LVDFK+EFG L  
Sbjct: 125 ALHDPLMNESDAIAFHLLTHEEHEQIWEISRQVNQLLTKLFADAGMLLVDFKVEFGTLPN 184

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           GEVVL DEFSPD  RLWD ET + MDKD +R+ +G LI+ YE V  RL
Sbjct: 185 GEVVLADEFSPDNCRLWDMETKDHMDKDVYRRQIGNLIDVYERVLARL 232


>UniRef50_Q2NCK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=346
           Tax=cellular organisms RepID=PUR7_ERYLH
          Length = 272

 Score =  200 bits (508), Expect = 4e-50,   Method: Compositional matrix adjust.
 Identities = 99/238 (41%), Positives = 150/238 (63%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M ++ ++Y GKAK +Y    P  ++  F++D +A +  +      KG++NN+ +  + ++
Sbjct: 1   MSRRRQIYEGKAKILYEGPEPGTIIQYFKDDATAFNAEKKGTISGKGVINNRISEHVFTR 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L+  GIPT   R L+  E LV++ +++P+E VVRN AAGS+ KRLGI EG  L   L + 
Sbjct: 61  LSHIGIPTHFIRRLNMREQLVRQCEIIPIEVVVRNVAAGSISKRLGIPEGEPLPHTLIEY 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D++ DP++ E +   F W S E +  +  +  + ND +  +F    + LVDFKLEF
Sbjct: 121 YYKDDSLGDPLIAEEHIACFNWASPEEMQDIASMAIRINDFMAGMFAAIDIRLVDFKLEF 180

Query: 181 G-LYKGE---VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G +Y G+   V+L DE SPDG RLWD  + EK+DKDRFR+ LGG  EAY+ VARRLG+
Sbjct: 181 GRIYDGDFSRVILADEISPDGCRLWDMNSGEKLDKDRFRRDLGGESEAYQEVARRLGL 238


>UniRef50_B1YJ02 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Bacteria RepID=PUR7_EXIS2
          Length = 235

 Score =  199 bits (507), Expect = 5e-50,   Method: Compositional matrix adjust.
 Identities = 97/228 (42%), Positives = 149/228 (65%), Gaps = 1/228 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK +Y+T++ D+L + ++++ +A +G +  +F  KG +NN+        LA AGI
Sbjct: 4   LYEGKAKRLYTTQDQDVLRIVYKDEATAFNGEKKAEFAGKGELNNRLTSHFFEVLAAAGI 63

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
           PT      S+ E LV+++ ++P+E VVRN  AGSL KRLGIEEG  L  P+ + + K+D+
Sbjct: 64  PTHFIEQTSEREQLVRRVTIIPLEVVVRNVVAGSLSKRLGIEEGTVLETPIVEFYYKDDS 123

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG-LYKG 185
           + DP+V  ++       + E L+ +++   + NDVL+  FD+ G+ L+DFKLE+G    G
Sbjct: 124 LGDPLVTPAHINLLKIATTEELSLLEQEANRVNDVLRPYFDEKGITLIDFKLEYGKTPAG 183

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           E++L DE SPD  RLWDKET E +DKD FR+++G LI+ Y+ +  RLG
Sbjct: 184 EILLADEISPDTCRLWDKETGEHLDKDVFRRNIGSLIDTYQTLFNRLG 231


>UniRef50_Q2GHH2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=Rickettsiales RepID=PUR7_EHRCR
          Length = 242

 Score =  198 bits (503), Expect = 1e-49,   Method: Compositional matrix adjust.
 Identities = 96/237 (40%), Positives = 151/237 (63%), Gaps = 4/237 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+ + ++Y GKAK +++T NP  ++  F+++ +A +  +      KG++NN  + F+M K
Sbjct: 1   MENKEKIYEGKAKIIFATLNPLEVIQHFKDEITAFNNKKAAIIHEKGILNNYISSFLMKK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L + GI T    LL+  E LVKK+ ++P+E V+RN AAG+  KR  I +G     P+ + 
Sbjct: 61  LIDKGIKTHFISLLNQREQLVKKITIIPIEVVIRNLAAGNFSKRFQIADGTPFKSPIIEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + KND + DPMV+E +  +F W++ + L ++K L+ K N++L +LF + G+ LVDFKLEF
Sbjct: 121 YYKNDELSDPMVSEGHILSFQWLTNQELEKIKILSLKINNILSELFFNVGIKLVDFKLEF 180

Query: 181 G-LYKGE---VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G L+  E   + L DE SPD  RLWD  T +++DKDR+R +LG +IE Y  VA +L 
Sbjct: 181 GKLHNDEQSDLFLADEISPDTCRLWDISTNKRLDKDRYRLNLGNVIEGYREVAHKLN 237


>UniRef50_A9VRE8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=155
           Tax=cellular organisms RepID=PUR7_BACWK
          Length = 239

 Score =  197 bits (502), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 101/234 (43%), Positives = 145/234 (61%), Gaps = 1/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK   LY GKAK +Y TE  D++ +E+++  +A +G +      KG +NN+    +  K
Sbjct: 1   MQKLELLYEGKAKRIYRTEAADMVWVEYKDSATAFNGEKKATITGKGRLNNEITTLLFRK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T     LSDTE LVKK+ ++P+E V RN  AGSL KRLG+EEG  L  P+ + 
Sbjct: 61  LQEVGIKTHFVEKLSDTEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTALTTPIVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D + DP+V E +       + E ++ +++   + N V+ + F    + LVDFKLEF
Sbjct: 121 YYKDDDLGDPLVTEDHIRLLNVATPEQVSVLRDAALQINQVMIEHFASCRVRLVDFKLEF 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G+  +GE++L DE SPD  RLWD+ + EK DKD FR+ LG L EAYE + +RLG
Sbjct: 181 GVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTEAYEEILKRLG 234


>UniRef50_Q38XX0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=27
           Tax=Lactobacillales RepID=PUR7_LACSS
          Length = 241

 Score =  197 bits (500), Expect = 3e-49,   Method: Compositional matrix adjust.
 Identities = 95/226 (42%), Positives = 148/226 (65%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK ++ST++P++L + +++  +A +G R EQ   KG VN + +  I + L++ GI
Sbjct: 6   LYSGKAKDLFSTDDPEVLKMIYKDQATALNGKRKEQITGKGEVNYEISKLIFAYLSQQGI 65

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
            T + + +S+TE LVKK+ ++P+E V+RN  AGS  ++ G   G  L  P+ + + KNDA
Sbjct: 66  ETHLIKNVSETEQLVKKVTIIPLEVVLRNVVAGSFARKFGQPLGQRLEQPIIEYYYKNDA 125

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE 186
           + DP +N S       V+   +A ++ +T + N +L KLF++ G+ L+DFKLEFG Y+G 
Sbjct: 126 LDDPAINISQATALKLVTPTEVATIEAMTKQINTLLIKLFNEIGIDLIDFKLEFGRYQGR 185

Query: 187 VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           ++L DEFSPD  RLWD++T   +DKD FRQ+ G L+  YE V +RL
Sbjct: 186 LILADEFSPDNCRLWDQKTHSSLDKDVFRQNKGDLVTVYETVLQRL 231


>UniRef50_B9EAY5 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Macrococcus caseolyticus JCSC5402 RepID=PUR7_MACCJ
          Length = 233

 Score =  189 bits (480), Expect = 7e-47,   Method: Compositional matrix adjust.
 Identities = 90/227 (39%), Positives = 144/227 (63%), Gaps = 1/227 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GKAK VYST+   +  +E++++ +AG+GA+ +    KG +NN    +   +LA  G+
Sbjct: 4   VYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLARQGL 63

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
            +   + LSDTE LVK + ++P+E VVRN AAGS+VKRLG ++G++   PL + + K DA
Sbjct: 64  ESHFIKKLSDTEQLVKAVTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYKEDA 123

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-G 185
           ++DP++ + + +  G    +++A +K      ND+L K+ D+  L L+DFK+EFG  + G
Sbjct: 124 LNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLVKMMDEMNLQLIDFKIEFGKDQDG 183

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            ++L DE SPD  R+WDK+T E  DKD +R+  G LI+ Y     +L
Sbjct: 184 NILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKL 230


>UniRef50_B8DTV0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=16
           Tax=Bacteria RepID=PUR7_BIFA0
          Length = 250

 Score =  189 bits (480), Expect = 7e-47,   Method: Compositional matrix adjust.
 Identities = 99/237 (41%), Positives = 143/237 (60%), Gaps = 5/237 (2%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK  +LY GKAK +Y+T++PD+L +E+ N  +AG+GA+  Q + KG +NN+    I   
Sbjct: 1   MQKLDKLYEGKAKKLYATDDPDVLWVEYMNQATAGNGAKKAQIEGKGELNNQITSVIFDL 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI +   + +SDTE LV+K+DM P+E ++RN AAGS  KR G+EEG  L+ P+ + 
Sbjct: 61  LKARGIDSHFVKRISDTEQLVRKMDMYPLEIIMRNTAAGSFAKRYGVEEGTALDKPILEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
            +K+D + DP +N+      G  S+E L  +       ND LK +F    + LVDFK+E 
Sbjct: 121 CVKSDELGDPFINDDGIVALGIASEEELDEISRQARAVNDALKDIFSKIDVQLVDFKIEE 180

Query: 181 G-LYKGEVVLGDEFSPDGSRLWD----KETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    G ++L DE +PD  RLWD       +E +DKD FR+ LG +I AYE +  RL
Sbjct: 181 GKTGDGRILLADEITPDTCRLWDLKDGSGQIEHLDKDLFRRDLGNIIPAYEEIYDRL 237


>UniRef50_A7X0V7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=58
           Tax=Bacilli RepID=PUR7_STAA1
          Length = 234

 Score =  187 bits (475), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 95/227 (41%), Positives = 141/227 (62%), Gaps = 1/227 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK ++ST   + L +E++++ +AG+GA+ +    KG +NN+    I   L E GI
Sbjct: 4   LYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQENGI 63

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
            +   + LS+TE LVK + ++P+E VVRN A+GS+ KRLG E G     PL + F KNDA
Sbjct: 64  ESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKNDA 123

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-G 185
           ++DP++ + + +     S E++  +K    K N+VLK+L D   L LVDFK+EFG  + G
Sbjct: 124 LNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTETG 183

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           +++L DE SPD  R+WDK T    DKD +R + G LIE Y+    +L
Sbjct: 184 QILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKL 230


>UniRef50_A0AJM6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=66
           Tax=Bacteria RepID=PUR7_LISW6
          Length = 237

 Score =  186 bits (472), Expect = 6e-46,   Method: Compositional matrix adjust.
 Identities = 95/227 (41%), Positives = 141/227 (62%), Gaps = 1/227 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GKAK ++ TE   +L + +++D +A +G R E F  KG +NN+    I S L EAGI
Sbjct: 6   VYEGKAKQLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITALIFSYLEEAGI 65

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
            +   R +S+TE LVK++ ++P+E VVRN  AGSL KRLG EEG E+   + + + K DA
Sbjct: 66  RSHFIRAISETEQLVKEVSIIPLEVVVRNVIAGSLAKRLGKEEGEEIPSAIVEFYYKEDA 125

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKG 185
           + DP +N+ +       +   +  +++     N+VL+ LF+   + L+DFKLEFG    G
Sbjct: 126 LDDPFINDDHVLYLEIATTNEMEVIRKAARSINEVLQVLFNQMNITLIDFKLEFGRDADG 185

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            ++L DE SPD  RLWDKET +K+DKD FR+++G L + Y  V  RL
Sbjct: 186 NILLADEISPDTCRLWDKETKQKLDKDVFRRNIGNLTDVYTEVLNRL 232


>UniRef50_Q8TX83 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=cellular organisms RepID=PUR7_METKA
          Length = 247

 Score =  186 bits (471), Expect = 7e-46,   Method: Compositional matrix adjust.
 Identities = 99/234 (42%), Positives = 146/234 (62%), Gaps = 2/234 (0%)

Query: 1   MQKQAELYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M++   +Y GKAK++Y   E+ +LLV+EFR+D +A +  +++  + KG+ N   +  +  
Sbjct: 1   MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFE 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L +AGIPT    L  +   +V++LDM  +E + RN A GSLV+RL  EEG +L+PP+ +
Sbjct: 61  VLEDAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVE 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K+D   DPMVN  +    G  ++E + RM+ELT + N+VL +   D  +ILVDFKLE
Sbjct: 121 FDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVNEVLSEFLKDCDIILVDFKLE 180

Query: 180 FGLYK-GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           FG+   GEVV+GDE SPD  R WD ET E +DKD FR+  G ++  Y   A R+
Sbjct: 181 FGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERI 234


>UniRef50_B5IMM2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Cyanobium sp. PCC 7001 RepID=B5IMM2_9CHRO
          Length = 255

 Score =  186 bits (471), Expect = 8e-46,   Method: Compositional matrix adjust.
 Identities = 98/236 (41%), Positives = 146/236 (61%), Gaps = 11/236 (4%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L+ GKAK V++T+ PDL+ +EF++D +A +  +  Q   KG  N + +  +  +LA   I
Sbjct: 10  LHEGKAKRVHATDRPDLVAVEFKDDATAFNALKKAQLSGKGWHNCQISALLFEQLASQDI 69

Query: 67  PTQMERLLSDTE-----CLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
           PT   R L++ E      LV+ + ++P+E V+RNRAAGSL +++ I  G  L PPL DL+
Sbjct: 70  PTHY-RGLAEAEHGGNWMLVRPVRIIPIEVVIRNRAAGSLCRQMPIHAGTPLEPPLLDLY 128

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
            K+D + DP++ E+  E    ++ E  A ++ L  + N  L K+FD  GLILVDFK+E G
Sbjct: 129 YKDDGLGDPLLTEARLERLALLTAEERADVERLAREVNTALVKVFDRVGLILVDFKIELG 188

Query: 182 LYK-GEVVLGDEFSPDGSRLWDKETLEK----MDKDRFRQSLGGLIEAYEAVARRL 232
               G++V+ DE SPD  RLWD+   +     +DKDRFRQ LGG++EAY  V +RL
Sbjct: 189 YTADGQLVVADEISPDTCRLWDRAVEDVNERILDKDRFRQDLGGVVEAYGQVLKRL 244


>UniRef50_Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Methanomicrobia RepID=PUR7_METBU
          Length = 238

 Score =  185 bits (469), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 99/230 (43%), Positives = 134/230 (58%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K  ELY GKAKT+Y TENP+ L+ EFR+  +A DG +  +   KG  N + +  I   L 
Sbjct: 2   KTEELYSGKAKTIYKTENPNELISEFRDSLTAFDGKKKSEATNKGYYNAQISKKIFEMLE 61

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
           E GI T    ++S  E LVKK+D++ +E + RN AAGS+ ++  +EEG     P+     
Sbjct: 62  EEGIKTHYLGMVSGNEMLVKKVDIILIEVIPRNIAAGSITRKYPVEEGTVFKEPVLVFDY 121

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           K+D   DPM+N+      G  ++E +  ++ +  K N +LK   +  G +L DFKLEFG 
Sbjct: 122 KSDEFGDPMINDDIAVVMGIATREEIDFIRSMALKINAILKSYLESNGFLLPDFKLEFGR 181

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             GE+VL DE S D  R WD ET E MDKD FR   G L +AYE VARRL
Sbjct: 182 VDGEIVLADEISCDTCRFWDVETGESMDKDLFRFDKGDLSKAYEKVARRL 231


>UniRef50_O57978 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=7
           Tax=cellular organisms RepID=PUR7_PYRHO
          Length = 238

 Score =  185 bits (469), Expect = 1e-45,   Method: Compositional matrix adjust.
 Identities = 100/233 (42%), Positives = 143/233 (61%), Gaps = 3/233 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M K  E+Y GKAK +   ++ D L++EF++D +A DG +  +F  KG +N + +      
Sbjct: 1   MVKLMEVYEGKAKKMIPIDD-DKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKL 59

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T    +      +V+KLDM P+E VVRN  AGSL KRL + EG EL  P+ +L
Sbjct: 60  LEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVEL 119

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + KND +HDPM+N  + +  G +S + + +++E+  K N++LK      G+ILVDFKLEF
Sbjct: 120 YYKNDELHDPMINYYHAKVLG-ISLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEF 178

Query: 181 GLYK-GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G  K G++VL DE SPD  R WD +T   +DKD FR   G LIEAY+ +  R+
Sbjct: 179 GKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERI 231


>UniRef50_A4SE69 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=25
           Tax=Bacteria RepID=PUR7_PROVI
          Length = 238

 Score =  184 bits (468), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 105/232 (45%), Positives = 146/232 (62%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M K   L+ GKAK V+ T++ DL++ EF++D +A +  +      KG+VNN  +  + + 
Sbjct: 3   MNKTTLLHEGKAKKVFLTDDADLVIQEFKDDATAFNNKKKGSIADKGVVNNAISCRLFTM 62

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E G+ T +   LSD + L ++LD++ VE VVRN AAGSLV+R G  EG  L  P+ + 
Sbjct: 63  LEEHGVNTHLVEKLSDRDMLCRRLDIIKVEVVVRNIAAGSLVRRYGFTEGTVLARPIVEF 122

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           +LK+D + DP++   +    G  + + L  +K      NDVLKK F D  L LVDFKLEF
Sbjct: 123 YLKDDDLDDPLMIAEHAVALGVATMDELEVLKSRAGAINDVLKKFFADRRLKLVDFKLEF 182

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G +KGE++LGDE SPD  R WD +T EKMDKDRFR  LGG+ +AY  V RR+
Sbjct: 183 GRHKGEILLGDEISPDTCRFWDLDTDEKMDKDRFRFDLGGVEDAYTEVQRRV 234


>UniRef50_A6Q3C7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=17
           Tax=Epsilonproteobacteria RepID=PUR7_NITSB
          Length = 239

 Score =  184 bits (466), Expect = 3e-45,   Method: Compositional matrix adjust.
 Identities = 99/234 (42%), Positives = 143/234 (61%), Gaps = 2/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   LY GKAK ++ T++ ++L+ EF++  +A D  +  +   KG +N K +  +   
Sbjct: 1   MKKTELLYEGKAKKIWKTDDENILIAEFKDSLTAFDAQKKSEEAGKGALNCKISANLFKL 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T     +S+ E ++KK +M+ +E VVRN A GSL KRLGI +G +L   L + 
Sbjct: 61  LEEQGIKTHFVECISENEMVIKKAEMIMIEVVVRNIATGSLTKRLGIPDGTKLPFALVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKEN-LARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
           + KNDA+HDP++N+ +      V  E+ L  +K L  + N VLK  FD A L LVDFK+E
Sbjct: 121 YYKNDALHDPLINDEHALILELVDHESELEELKRLGREINVVLKSFFDKANLNLVDFKVE 180

Query: 180 FGL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           FG   +G ++L DE SPD  R WDK + EK+DKD FR  LG +  AYE V +R+
Sbjct: 181 FGKDSEGNIILADEISPDSCRFWDKTSGEKLDKDLFRHDLGNVKVAYEEVLKRI 234


>UniRef50_O26272 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Euryarchaeota RepID=PUR7_METTH
          Length = 248

 Score =  184 bits (466), Expect = 3e-45,   Method: Compositional matrix adjust.
 Identities = 97/225 (43%), Positives = 134/225 (59%), Gaps = 1/225 (0%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK V  T++P+++ + FR+D +AGDG + +  + KG  N+  +  I   L EAG+
Sbjct: 9   LYSGKAKDVLLTDDPEIVAVRFRDDITAGDGEKKDTLEMKGYYNSVISAKIFEVLEEAGV 68

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
           PTQ   L      L +KL+M+P+E + RN AAGS+V+R    EG E  PPL  +  K+D 
Sbjct: 69  PTQYLELREPGCILARKLEMIPIEVITRNIAAGSIVRRFPFTEGQEFVPPLIQMDYKSDE 128

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKG 185
             DPM+N+      G  +++ L  ++ +T   N VL+      GLIL DFKLEFG    G
Sbjct: 129 HGDPMLNDDIILALGIATRDELEEIRRITLHINSVLRDFLKSRGLILPDFKLEFGRDSSG 188

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVAR 230
            + LGDE SPD  RLWD ET E +DKD FR+   G++ AY  VAR
Sbjct: 189 RIRLGDEVSPDTCRLWDMETGEPLDKDIFRRGEEGVVGAYRRVAR 233


>UniRef50_C6I122 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6I122_9BACT
          Length = 242

 Score =  181 bits (458), Expect = 3e-44,   Method: Compositional matrix adjust.
 Identities = 95/229 (41%), Positives = 140/229 (61%), Gaps = 1/229 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
           A+LY GKAK +Y+T +P +LV EF++D +A +  +   F  KG +N + +  +   LA  
Sbjct: 7   AKLYEGKAKILYATTDPRILVQEFKDDLTAFNAQKKGTFFGKGALNCQISAVLFELLASR 66

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+P     L +    L+ +L+MVP+E VVRNR AGSL KRLGI EG EL+ P+ + + K 
Sbjct: 67  GVPVHFRSLETPRRMLIDRLEMVPLEVVVRNRVAGSLAKRLGIPEGEELSFPVVEWYYKR 126

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           D + DPMVN  +       S   L +++E+  K N++L   + + G++LVD KLEFG   
Sbjct: 127 DDLGDPMVNRDHIRVLKLASDAVLDKIREIALKTNEILLPFYRERGILLVDMKLEFGWNP 186

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G++VLGDE   D SRLW+ ET  ++DKD FR  LG + E YE +  ++
Sbjct: 187 AGDLVLGDEIDGDTSRLWEAETGVRLDKDLFRMDLGSVKEGYEKIYEKV 235


>UniRef50_D0JBF3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Blattabacterium RepID=D0JBF3_BLASB
          Length = 242

 Score =  179 bits (453), Expect = 8e-44,   Method: Compositional matrix adjust.
 Identities = 90/237 (37%), Positives = 147/237 (62%), Gaps = 4/237 (1%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  L  GK K +Y+T N   +++ +++  +A DG++ +    KG++NN+ +  I   + 
Sbjct: 6   KKNLLSEGKTKKIYTTNNSLEVLIHYKDSITALDGSKNQFLQDKGILNNEISTLIFKFIN 65

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GI T   R +++ E L  K+D++P+E VVRN  AGS+ KRL I+EGI L  P+F++F 
Sbjct: 66  SCGIKTHFIRKINNREQLCYKVDIIPLEFVVRNIVAGSMSKRLNIQEGIRLLNPIFEIFY 125

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           KND + DP++N+ +    G +S E +  +  +    N++LKK F D  +ILVDFK+EFG 
Sbjct: 126 KNDKLKDPLINDHHAVFLGIISYEEINAIYRIVSNVNNILKKYFLDKNIILVDFKIEFGK 185

Query: 183 Y-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLG---GLIEAYEAVARRLGVQ 235
             + +++L DE SPD  R WDK+T++K+DKD FR  L     +++ Y  + +RL V+
Sbjct: 186 NDQNDILLSDEISPDTCRFWDKKTMKKLDKDPFRIGLKEKEEVLDIYMEILKRLNVR 242


>UniRef50_A4FYT6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=11
           Tax=cellular organisms RepID=A4FYT6_METM5
          Length = 245

 Score =  178 bits (451), Expect = 1e-43,   Method: Compositional matrix adjust.
 Identities = 93/229 (40%), Positives = 139/229 (60%), Gaps = 2/229 (0%)

Query: 7   LYRGKAKTVYSTE-NPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +Y GKAK++Y  E N   +++EFR+D +AG+GA+ +    KG +N   +  +   L +  
Sbjct: 14  IYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNTLISNELFKILEQNN 73

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           +PT +   +     + K + ++P+E +VRN AAGSL K+   E+G  L   +     KND
Sbjct: 74  VPTHLIEYIEPNHMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQVLKTAVTQFDYKND 133

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG-LYK 184
              DPM+N       G  ++E L  +K+L  K NDVLK  FD+ G+ILVDFK+E G    
Sbjct: 134 DYGDPMLNNEITIELGLATEEELVEIKKLALKVNDVLKGFFDEKGIILVDFKIEVGKTVD 193

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G++V+ DE SPD  RLWDKET + +DKD FR+ LG ++E Y+ VA+R+G
Sbjct: 194 GDIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKTVAKRIG 242


>UniRef50_Q3AHS3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=21
           Tax=Bacteria RepID=PUR7_SYNSC
          Length = 250

 Score =  175 bits (444), Expect = 9e-43,   Method: Compositional matrix adjust.
 Identities = 91/231 (39%), Positives = 141/231 (61%), Gaps = 5/231 (2%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK V+++ +PD +++EF+ND +A +  +  Q D KG +N + +  +   L   G+
Sbjct: 9   LYEGKAKRVFASTDPDRVLVEFKNDATAFNAQKKAQLDGKGRLNCQISARLFDLLEREGV 68

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
           PT    L  +T  LV+++ ++P+E V+RN A GSL ++  I EG  + P L DL+ K+D+
Sbjct: 69  PTHYCGLAGETWMLVRRVRIIPLEVVLRNIATGSLCRQTPIAEGTAIEPALLDLYYKDDS 128

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-G 185
           + DP++ E+  +  G      L+ +++L  + N VL   FD+  L LVDFKLE GL   G
Sbjct: 129 LGDPLLTEARVQLLGVADTAQLSAIEQLARRVNAVLLPFFDELDLQLVDFKLELGLASDG 188

Query: 186 EVVLGDEFSPDGSRLWDKETLEK----MDKDRFRQSLGGLIEAYEAVARRL 232
            ++L DE SPD  RLWD+         +DKDRFR+ LGG++EAY  V +R+
Sbjct: 189 TLLLADEISPDTCRLWDRRNSNAEDRILDKDRFRKDLGGVMEAYGEVLKRV 239


>UniRef50_Q1AXB9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacteria RepID=Q1AXB9_RUBXD
          Length = 237

 Score =  174 bits (440), Expect = 3e-42,   Method: Compositional matrix adjust.
 Identities = 94/231 (40%), Positives = 139/231 (60%), Gaps = 2/231 (0%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  LY GKAK V+ T    +L+  ++++ +A +  +   +  KG  N   +  + + L 
Sbjct: 2   KRTLLYEGKAKQVFETGEEGVLLHRYKDEATAFNARKRGSWAGKGRANASISAAVFAYLE 61

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GIPT     + +     ++L M+PVE +VRN AAGSL + LG EEG  L  P+ +L  
Sbjct: 62  RRGIPTHFIEQVDEVTLKTRRLRMLPVEIIVRNLAAGSLARLLGYEEGRPLKAPVVELCY 121

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           KNDA+ DPM+N  +    G ++ E L   +E   + N+ L+  F++ G++LVDFK+E G 
Sbjct: 122 KNDALGDPMLNWYHFRELG-LTDEELRACEEFGLRVNEALRPFFEERGMVLVDFKIEVGR 180

Query: 183 -YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
              G +VL DE SPD  RLWDKET +++DKDRFR+ LGG+ EAYE V RR+
Sbjct: 181 DAGGSLVLADEISPDTCRLWDKETGQRLDKDRFRRDLGGVEEAYEEVLRRV 231


>UniRef50_Q7V0C7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Prochlorococcus marinus RepID=PUR7_PROMP
          Length = 242

 Score =  172 bits (435), Expect = 1e-41,   Method: Compositional matrix adjust.
 Identities = 91/232 (39%), Positives = 138/232 (59%), Gaps = 5/232 (2%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GKAK +++ E+ D +++EF++D +A +  +  +F+ KG +N   +  I   L +  I
Sbjct: 8   IYEGKAKKIFAYEDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFEFLIKNNI 67

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
           PT    L ++   + +K+ ++P+E V+RN A GSL K+  I+ G  L  PL D +LKND 
Sbjct: 68  PTHYIGLKNNNSMIAQKIKIIPLEVVLRNTAYGSLCKQTTIKPGTVLESPLIDFYLKNDT 127

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKG 185
           ++DP++ +        V +E L  +  +T K N +LKK F +  L LVDFKLEFG    G
Sbjct: 128 LNDPLLTKDRINLLKIVDEEELDFISNMTLKINKLLKKFFYNIKLDLVDFKLEFGYNSNG 187

Query: 186 EVVLGDEFSPDGSRLWD----KETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           ++VLGDE SPD  RLWD       +  +DKDRFR  LGG IEAY  + +R+ 
Sbjct: 188 QIVLGDEISPDNCRLWDLNQKNGMIVSLDKDRFRNDLGGFIEAYSEINKRIN 239


>UniRef50_P73471 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=69
           Tax=Bacteria RepID=PUR7_SYNY3
          Length = 264

 Score =  169 bits (427), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 90/237 (37%), Positives = 139/237 (58%), Gaps = 5/237 (2%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +LY GKAK +Y TE+PD+L+  F++D +A +  +  Q   KG +N   +  +   L   G
Sbjct: 19  KLYEGKAKILYPTEDPDVLLTIFKDDATAFNAQKKGQIQGKGAINCAISAALFRWLETLG 78

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           IPT       + + LVK ++++P+E VVRN AAGSL K+ G++EG+ L  PL + + K+D
Sbjct: 79  IPTHYIDCPQNDQMLVKAVNIIPLEVVVRNIAAGSLCKQTGLKEGLVLPNPLVEFYFKDD 138

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YK 184
           A+ DP++        G   +  L  +K+L    N  L++ F    + LVDFKLEFG   +
Sbjct: 139 ALGDPLLTWERALLLGVTDEARLQTLKDLALNINQHLQRFFAQCDITLVDFKLEFGGDRQ 198

Query: 185 GEVVLGDEFSPDGSRLWDKETLEK----MDKDRFRQSLGGLIEAYEAVARRLGVQLD 237
           G+++L DE SPD  RLWD    +     +DKDRFR+ LG +  AY+ V +R+  Q++
Sbjct: 199 GKIILADEISPDTCRLWDNAQADPQARVLDKDRFRRDLGSIEAAYQTVEKRVLSQIE 255


>UniRef50_A9BIH1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Petrotoga mobilis SJ95 RepID=A9BIH1_PETMO
          Length = 238

 Score =  159 bits (401), Expect = 1e-37,   Method: Compositional matrix adjust.
 Identities = 85/230 (36%), Positives = 129/230 (56%), Gaps = 3/230 (1%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GKAK VY  +   LL+ EF++D +A +G + +Q   KG +N + + F    L   GI
Sbjct: 10  LYEGKAKKVYKFDEKKLLI-EFKDDVTAFNGLKKDQILNKGKINKEISKFFFEMLNNQGI 68

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDA 126
            T       +   + K  D++P+E ++RN  AG   KR G+++G+  + PL +  LKND 
Sbjct: 69  NTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLVEFSLKNDE 128

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE 186
           + DPM+ +         ++  L  +  ++ K N++L       G+ILVDFKLEFG+ K +
Sbjct: 129 LGDPMIAKDAILLLKITTENVLDEIASISKKVNNILSDYLKSKGIILVDFKLEFGISKND 188

Query: 187 --VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
             V L DE SPD  R WD  T+E +DKD +R++ G LI AYE +  RL +
Sbjct: 189 NKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI 238


>UniRef50_B8D414 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Desulfurococcus kamchatkensis 1221n
           RepID=B8D414_DESK1
          Length = 253

 Score =  155 bits (393), Expect = 9e-37,   Method: Compositional matrix adjust.
 Identities = 90/234 (38%), Positives = 142/234 (60%), Gaps = 6/234 (2%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY GK K VYS + P+LLVLEF++D +A DG   +    KG++N + + ++   + + GI
Sbjct: 16  LYEGKTKRVYS-KTPELLVLEFKDDVTAMDGLVKKTMPGKGVINARLSAYLFKHIEKQGI 74

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGI-ELNPPLFDLFLKND 125
            T +     D    V++L+M+P+E +VRN A GSL+KR+ + + + ELNPPL +   K+D
Sbjct: 75  ETHLVEYNGDRFLTVRRLEMLPIEVIVRNYAYGSLLKRMPLYKKMQELNPPLVEFHYKDD 134

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK- 184
           ++HDP++        G ++   L  + E T K N+VL +LF  AGL LVDFK+E+G  + 
Sbjct: 135 SLHDPLITPEDITYTGLLTSGELRWLIEATIKINNVLSELFSGAGLKLVDFKVEYGRNRN 194

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQS--LGGLIEAYEAVARRLGVQL 236
           G ++LGDE + D  R+ D +    +DK+ FR++  +  L  AY  +  RLGV +
Sbjct: 195 GRLILGDELTGDSIRVLDDKG-NHLDKEVFRKTGDIEALRTAYIELCNRLGVNV 247


>UniRef50_Q03E76 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=15
           Tax=Bacilli RepID=PUR7_PEDPA
          Length = 242

 Score =  152 bits (383), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 83/234 (35%), Positives = 132/234 (56%), Gaps = 1/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   +  GKAK +Y+T+  DL+ +E+ +  +A +G R +    KG +NN+ +  +  +
Sbjct: 1   MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQ 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI T   + LS+ E L +K+ ++P+E VVRN A+GS  ++  +      + P+ + 
Sbjct: 61  LVAKGIHTDFVQKLSNNEQLNRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DP +N +       +  E   R++++  + N +LK+ F  A L LVDFK+EF
Sbjct: 121 FYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQILKERFAKAHLQLVDFKVEF 180

Query: 181 G-LYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G     E+VL DE SPD  RL D  T E +DKD FR+  G L+  Y+ V  RL 
Sbjct: 181 GKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLN 234


>UniRef50_D2EKX6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Pediococcus acidilactici 7_4 RepID=D2EKX6_PEDAC
          Length = 244

 Score =  151 bits (382), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 85/233 (36%), Positives = 132/233 (56%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   +  GKAK +Y+T+  D++ +E+ +  +  +G R +Q   KG +NN+ +  +   
Sbjct: 1   MKKTTLIKEGKAKRLYNTDEADVVWVEYLDQATTLNGKRRDQVIGKGALNNQIDCILFEM 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI T   + +SDTE L  K+D++P+E VVRN AAGS  ++  +    E + P+ + 
Sbjct: 61  LGAKGIHTDFIKKISDTEQLNYKVDVIPLEVVVRNAAAGSFQRKFAVPYLREFDQPIVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DP +N +       +S      ++ L  + N +LK+ F  A L LVDFK+EF
Sbjct: 121 FYKSDELDDPFINTNQAVALKIISYAEGEILENLALQINRLLKEQFWQAHLQLVDFKVEF 180

Query: 181 G-LYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    G+++L DE SPD  RL D  T   +DKD FR+  G L+  Y+ V RRL
Sbjct: 181 GKTADGKIMLADEISPDSCRLVDLTTKTSLDKDVFRKKTGDLVTVYQEVLRRL 233


>UniRef50_C6XGE3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Alphaproteobacteria RepID=C6XGE3_LIBAP
          Length = 255

 Score =  148 bits (374), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 81/238 (34%), Positives = 129/238 (54%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+ +  +Y  K K +Y    P  L+  F++D    +  R    + KG++NN+ + ++ ++
Sbjct: 1   MRPRNPVYEEKTKIIYEGLEPGTLIQFFKDDNLLENNPRCATLNGKGVLNNRISEYMFTQ 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L + GIP    R ++  E LV+ ++M+P+   VRN AAGSL KRL I EG+ L   L + 
Sbjct: 61  LGKIGIPHYFIRRINMREQLVRDVEMIPLLITVRNTAAGSLAKRLNIPEGLSLPRSLVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           +   D+    +V+E +   F W ++  +  M  L+ + ND +  LF    + LVDF+++ 
Sbjct: 121 YYLPDSSEKTLVSEEHITAFNWANQSEVEEMTALSIRINDFMTGLFLGINIQLVDFRIKC 180

Query: 181 GLYKGE----VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G    +    +VL DE  PD  RLWD    E+ DK RF +S   L+E Y  VARRLG+
Sbjct: 181 GRLLDDDILRIVLADEIFPDCCRLWDLSKKEECDKKRFSKSNDQLLEGYSEVARRLGI 238


>UniRef50_Q4J8G0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=Sulfolobaceae RepID=PUR7_SULAC
          Length = 235

 Score =  146 bits (369), Expect = 5e-34,   Method: Compositional matrix adjust.
 Identities = 83/220 (37%), Positives = 133/220 (60%), Gaps = 4/220 (1%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           GK K VY   +P+  +L F++  +AGDGAR ++   KG +N + +      L +  I T 
Sbjct: 9   GKTKIVYEF-DPEHYLLRFKDSITAGDGARKDELPGKGTLNAQTSALFFRLLEKNDIRTH 67

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAMHD 129
              +  +   +V KL M+PVE V+RN A GS+VKRL I+EG   +PP+ + FLK+D  HD
Sbjct: 68  YVGMYDEKTMIVTKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFDPPIVEFFLKDDLRHD 127

Query: 130 PMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVV 188
           P++N S+ + F  ++++    ++E+  K N V+K    + GL+L D KLEFG  K   ++
Sbjct: 128 PLLNYSHLQYFNLLTRKEAEIVEEVIVKVNAVMKNFLKERGLVLYDLKLEFGKDKDNNLI 187

Query: 189 LGDEFSPDGSRLWDKETLEKMDKDRFR--QSLGGLIEAYE 226
           +GDE + D  R+ D++T + +DKD +R  +SL  + +AYE
Sbjct: 188 VGDEITLDSMRVRDEKTNKILDKDLYRKGESLEVVKKAYE 227


>UniRef50_Q03Y92 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=Leuconostocaceae RepID=Q03Y92_LEUMM
          Length = 249

 Score =  145 bits (365), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 76/226 (33%), Positives = 126/226 (55%), Gaps = 1/226 (0%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y+GKAK VY T+NP +L + + +  +A +G   E    KG +N+  ++ +   L   GI 
Sbjct: 19  YQGKAKQVYFTDNPTILWVHYMDQATALNGKVHENIPEKGQLNSAISHILFEHLTRQGIE 78

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAM 127
                 +S+T+ L   LD++P+E V RN A+G  V +       +L P + + + K+D +
Sbjct: 79  NHYLSSVSETDELDLALDILPIEVVTRNYASGHFVSKFNATPMQKLTPVVQEFYYKSDEL 138

Query: 128 HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKGE 186
            DP +N+S     G+ +   L +++    + N  L ++FD+  + LVDFKLE+G   +G+
Sbjct: 139 DDPFMNDSQILALGFATLSELTKLRAYAQEVNQALTEIFDEININLVDFKLEYGRDSEGK 198

Query: 187 VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           ++L DE SPD  RL D++T + +DKD FR+  G +   Y  V  RL
Sbjct: 199 LILADELSPDNMRLVDQKTGKSLDKDVFRKHAGDVTVGYRDVLSRL 244


>UniRef50_C2U7A6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Bacillus cereus RepID=C2U7A6_BACCE
          Length = 239

 Score =  143 bits (361), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 83/234 (35%), Positives = 129/234 (55%), Gaps = 4/234 (1%)

Query: 1   MQKQAELYR-GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M K   LY  GK+K++Y  E  D +++ F +  S+    +  +    G++  +F+  I  
Sbjct: 1   MTKNGLLYTCGKSKSMYYGEENDSIIMHFLDSVSSYTQNKNARIIGTGILRCEFSSHIFE 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L + G+P      +      V KLDM+ +E + RN AAGS+V+   I+ G   N P+  
Sbjct: 61  LLHKKGVPNHYISNIGMGRMKVNKLDMIKLEIIPRNIAAGSIVRNYPIQYGQVFNQPILK 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
           L LK    +DPM+N  Y    G  +K  +  ++E+ ++ N +LK    + G+ LVDFK E
Sbjct: 121 LDLKYS--NDPMMNSDYIVAMGIATKREIEVIREIAFELNAILKDFLLERGVKLVDFKFE 178

Query: 180 FGL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G    G++V+GDE SPDG RLWD ET + +DKD FR + G L+ AYE + +R+
Sbjct: 179 MGRNAAGDLVIGDEISPDGMRLWDIETNQSLDKDVFRYNKGDLVHAYEEILKRI 232


>UniRef50_A8AAS3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ignicoccus hospitalis KIN4/I RepID=A8AAS3_IGNH4
          Length = 235

 Score =  141 bits (355), Expect = 2e-32,   Method: Compositional matrix adjust.
 Identities = 92/238 (38%), Positives = 140/238 (58%), Gaps = 15/238 (6%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GK K VY  +  D ++L+F++  +A DG ++E+   KG VN +F   +M  L + G+
Sbjct: 4   IYEGKTKKVYDMD--DKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQHGV 61

Query: 67  PTQ-MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFDLFLKN 124
            T  + R  ++ E +  K   +P+E +VRN A GSL+KRL I E+G  L  P+F++  K+
Sbjct: 62  KTHFLSR--NEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYKS 119

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           D +HDP++ E      G VSK+ +  ++E T K N++L +LF+ AG  L+DFK+E+G+ +
Sbjct: 120 DELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDFKVEYGITE 179

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGG------LIEAYEAVARRLGVQ 235
            G VVL DE SPD  R    +  E  DKD FRQ   G       +E  EA+   LGV+
Sbjct: 180 DGRVVLIDELSPDSFRAH--KGGEAYDKDLFRQGASGEEVLKKYVELLEALREALGVE 235


>UniRef50_B1LCA5 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Thermotogaceae RepID=PUR7_THESQ
          Length = 230

 Score =  139 bits (351), Expect = 6e-32,   Method: Compositional matrix adjust.
 Identities = 90/222 (40%), Positives = 120/222 (54%), Gaps = 5/222 (2%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK K V  T   D  +LEF++D +AGDG + +    KG +  +    +M  L+E  I 
Sbjct: 3   YEGKTKIVKVT--GDYALLEFKDDITAGDGLKHDVLTGKGSICAETTAILMKYLSEKDIK 60

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAM 127
           T +   +      V  L M P+E VVR + AGS V+R G  EG +L  PL + F+K+D  
Sbjct: 61  THLVEYIPPRTLKVIPLKMFPLEVVVRLKKAGSFVRRYGGAEGEDLPVPLVEFFIKDDER 120

Query: 128 HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GE 186
           HDPMV   + E  G  +K+   +MKE   K    LK+ F+ A   L D K EFGL K G 
Sbjct: 121 HDPMVCVDHLEILGIATKKQAEKMKEAAVKITLALKEFFERANFELWDIKYEFGLDKDGN 180

Query: 187 VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAV 228
           VVLGDE SPD  RL +K   E  DKD +R+ LG  ++ Y  V
Sbjct: 181 VVLGDEISPDTFRLRNKG--EIFDKDVYRRDLGDPLKKYREV 220


>UniRef50_A8MCJ8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Caldivirga maquilingensis IC-167 RepID=PUR7_CALMQ
          Length = 241

 Score =  137 bits (345), Expect = 3e-31,   Method: Compositional matrix adjust.
 Identities = 90/234 (38%), Positives = 129/234 (55%), Gaps = 7/234 (2%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GKAK VY   N +L V+EF+++ +A DGAR E    KG +      F MS L E+G+
Sbjct: 9   IYEGKAKRVYLINNEEL-VMEFKDEVTALDGARKEYAPGKGKLAASQTAFFMSYLNESGV 67

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG-IEEGIELNPPLFDLFLKND 125
            T       D    V++L M+PVE +VRN A GS ++R+  I+   +   PL +  LKND
Sbjct: 68  RTHFINWDGDRRIHVRRLRMIPVEVIVRNYAYGSFIRRMPLIKPLTKFTTPLVEFHLKND 127

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YK 184
            +HDP++        G  S E +  ++ ++ K N +L +L    GL LVDFKLEFG+   
Sbjct: 128 ELHDPLILIEDIIEAGLTSMEQVMEIRSVSLKVNHLLSELLGKYGLTLVDFKLEFGVNSN 187

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQ--SLGGLIEAYEAVARRLGVQL 236
           G +VL DE S D  R+      + +DK+ FR   S+  LIEAY  +   LG+ L
Sbjct: 188 GALVLADELSGDTMRVLMNG--KHLDKELFRMGGSVKELIEAYSRLNSILGLGL 239


>UniRef50_A8GML2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=16
           Tax=Proteobacteria RepID=PUR7_RICAH
          Length = 236

 Score =  122 bits (306), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 71/233 (30%), Positives = 122/233 (52%), Gaps = 5/233 (2%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           + ++Y+G +K +YS E   LL++ F +D    +   I +   KG++NN  + F+M KL  
Sbjct: 2   KTQIYKGSSKILYSAEEDFLLIMAF-SDNGILESGEIIEVSGKGVLNNNISSFLMDKLEM 60

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
            GI       ++  E L++ +++ PV+ ++ + A G  VK  G++EG   + P+ D  ++
Sbjct: 61  IGIENHFIEKINMREQLIQYVEVFPVQVIISSVACGRFVKEFGMDEGYVFDKPIIDFKVR 120

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG-L 182
           +     P+VNE     F W++ + +  +KE   +    L  LF   G+ LV+ KLEFG +
Sbjct: 121 SREFKYPIVNEYQILNFSWLTLDEIKAVKEQALRIYAFLSGLFMGVGIRLVECKLEFGRV 180

Query: 183 YKGE---VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             GE   ++L DE SPD  RLW   + EK+  +          E+Y+ +A RL
Sbjct: 181 LNGEESIIMLTDEISPDNCRLWHIHSNEKLGFELLENKPNKAFESYQLIADRL 233


>UniRef50_A5CCM2 Phosphoribosylaminoimidazole-succinocarboxamidesynthase n=2
           Tax=Orientia tsutsugamushi RepID=A5CCM2_ORITB
          Length = 252

 Score =  112 bits (280), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 64/233 (27%), Positives = 119/233 (51%), Gaps = 6/233 (2%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +++ G +K +Y  +   L+  +F  D    +  ++ Q   KG++NN  + +I  +++  G
Sbjct: 16  KIFEGNSKIIYRIDEHTLI--QFFKDDMRINAEKVIQVSGKGVLNNVISNYIFKRVSMVG 73

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           I   + + ++  E L+  L+++PV+  + N A+G  V + GIE+G   + P+ D  +K+ 
Sbjct: 74  INHHLIQKINMREQLIYTLNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDFMVKHG 133

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG---- 181
           A + P++NE     F WV    L  +K L  K    L  +F    + LV+ +LEFG    
Sbjct: 134 ANNYPIINEDQMIKFNWVDYYELKNIKTLALKLYTFLVGMFASINIRLVECQLEFGRINN 193

Query: 182 LYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           L    ++L DE +PD  +LWD ++  K+  +R    L   I  Y+ + +R  +
Sbjct: 194 LSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNL 246


>UniRef50_P22234 Phosphoribosylaminoimidazole carboxylase n=88 Tax=Metazoa
           RepID=PUR6_HUMAN
          Length = 425

 Score =  112 bits (279), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 71/221 (32%), Positives = 113/221 (51%), Gaps = 11/221 (4%)

Query: 6   ELYRGKAKTVYST-ENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
           +LY GK K VY   ++P  ++L+ ++  +AG+ AR    + K  ++NK    I   L EA
Sbjct: 12  KLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEA 71

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFDLFLK 123
           GI T   R   +T  +  + +M+P+E V R  A GS +KR  G++EG +  PP  +LF K
Sbjct: 72  GIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFK 131

Query: 124 NDAMHDPMVNE------SYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFK 177
           +DA +DP  +E       +C     + +  +  M   T    ++L+K +      LVD K
Sbjct: 132 DDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMK 191

Query: 178 LEFG--LYKGEVVLGDEFSPDGSRLWDK-ETLEKMDKDRFR 215
           +EFG  +   E+VL D    D  RLW   +  ++ DK  +R
Sbjct: 192 IEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYR 232


>UniRef50_Q648Z8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=uncultured archaeon GZfos35D7 RepID=Q648Z8_9ARCH
          Length = 249

 Score =  110 bits (275), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 74/242 (30%), Positives = 123/242 (50%), Gaps = 22/242 (9%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           GK+K ++  +       EF + T+A DG + ++F  KG V  + + +    L EAGIPT 
Sbjct: 9   GKSKDIFEEDGKTFF--EFTDRTTAFDGVKEDEFSHKGEVCCRLSTYWFEILEEAGIPTH 66

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--GIEEGIELNPPL--------FD 119
               +      V+ LD++P+E + RN  AGS+++R   G    IE+ P L         +
Sbjct: 67  FRAFVPPNIMEVEPLDILPIEVIWRNFVAGSILRRHERGESLPIEIEPRLGARIPGGMVE 126

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K +A   P+  +   +  GW++   L  ++E T   N+++ +     G+IL DFK+E
Sbjct: 127 FTTKFEAKDRPIDEQEILDN-GWLTSAELDSIRECTRLTNEIMSERLLKRGIILADFKIE 185

Query: 180 FGLYKG---EVVLGDEF-SPDGSRLWDKE-----TLEKMDKDRFRQSLGGLIEAYEAVAR 230
           FG  K    +++L DE  +PDG R WD++      +E +DKD +R   G L + Y  + R
Sbjct: 186 FGRDKNAAEKILLADEVGTPDGCRFWDRDAYEQGVIESLDKDVYRYDKGDLSDVYLRIQR 245

Query: 231 RL 232
           R+
Sbjct: 246 RI 247


>UniRef50_A3MXE4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Thermoproteaceae RepID=PUR7_PYRCJ
          Length = 240

 Score =  109 bits (272), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 74/224 (33%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GKAK VY T    L+V  F+++ +AGDGAR ++   KG +  + +  +   L   G+
Sbjct: 7   VYEGKAKAVYKTREGLLMV--FKDEVTAGDGARRDKAPGKGALAAETSTLLFQYLQGRGV 64

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNP---PLFDLFLK 123
            T     +     LVK   + P+E +VR +A GS +KR+   +   L P   P+ +   K
Sbjct: 65  TTHYLMFVPPNAILVKPAQVPPLEVIVRFKAYGSYLKRM--PKAKPLTPFAKPIVEFHYK 122

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           +D++HDP++ E      G ++   LA +K++  +A   L++L+       VD K EFG  
Sbjct: 123 DDSLHDPLILEDDVVEAGLLTAGELAAVKDMALRAASALRELYASVDCDFVDVKFEFGRV 182

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQS--LGGLIEAY 225
            GE+VL DE S D  RL      E  DK+ +R++    GL+E Y
Sbjct: 183 GGELVLVDEVSGDTFRLLCGG--EHFDKEYYRKTGDAVGLVERY 224


>UniRef50_A9A5G9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Thaumarchaeota RepID=PUR7_NITMS
          Length = 274

 Score =  105 bits (261), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 76/231 (32%), Positives = 115/231 (49%), Gaps = 27/231 (11%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L  GK K +Y  +   LL  +F +  SA D    +   RKG V  KF  F  ++L    +
Sbjct: 4   LTSGKVKDLYDVDESTLL-FKFSDRVSAYDVKFKQDIPRKGEVLCKFAEFWFNEL---DV 59

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-----LGIEEGI------ELNP 115
           P    +  S+ E LVKK+ M+P+ECVVR    GSLV R     + + EG       +L  
Sbjct: 60  PNHFIKRESENEILVKKMKMLPIECVVRGYFYGSLVSRWKKGEVQVPEGTNTTLAAQLPE 119

Query: 116 PLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVD 175
           P+FD   K++  HD  ++++       VS+E    +++ + +    + K+ DD G IL D
Sbjct: 120 PIFDPTTKSE--HDIPIDKNKAIEMNLVSEEQYNWLEKTSIEIYKKMAKITDDVGFILAD 177

Query: 176 FKLEFGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYE 226
            KLEFG+   ++ LGD   PD  RLW K++ E          +G + EAY+
Sbjct: 178 LKLEFGILDDQITLGDSIGPDEYRLWPKDSFE----------VGKIQEAYD 218


>UniRef50_B8GCM2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Chloroflexi (class) RepID=PUR7_CHLAD
          Length = 250

 Score = 98.6 bits (244), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 64/214 (29%), Positives = 100/214 (46%), Gaps = 3/214 (1%)

Query: 7   LYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           L  GK K VY+   +PDL +L  ++  +AGDGAR      KG +  +    +   L  AG
Sbjct: 7   LSEGKTKIVYAHPTDPDLAILFHKDGITAGDGARRHVIAGKGALAGQTTANVFRFLNRAG 66

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           I T           +V++  M+P+E V+R   AGS ++R     G   +PPL + FLK+D
Sbjct: 67  IATHFIEAPEPKLTVVRRCVMIPLEVVMRRLPAGSYLRRYPEAAGQRFDPPLVEFFLKDD 126

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-K 184
           A HDP +        G  +   + +M     +    L+  +    + LVD K+EFG    
Sbjct: 127 ARHDPQITPDEIVAQGIATPAEVEQMTMTGQQVFTTLEAAWAKLDVTLVDLKIEFGRAGD 186

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQS 217
           G +++ D    D  R+W      +M DK  +R +
Sbjct: 187 GSLLVADVIDNDSWRIWPGGDPNRMLDKQVYRNA 220


>UniRef50_UPI00006A4774 PREDICTED: similar to phosphoribosylaminoimidazole carboxylase,
           phosphoribosylaminoribosylaminoimidazole
           succinocarboxamide synthetase n=1 Tax=Ciona intestinalis
           RepID=UPI00006A4774
          Length = 471

 Score = 96.3 bits (238), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 71/244 (29%), Positives = 122/244 (50%), Gaps = 23/244 (9%)

Query: 10  GKAKTVY--STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           GK K VY  +T+ P   ++  ++  +AGDGA+    + K  +++  N  +M  L + G+ 
Sbjct: 59  GKTKVVYEINTKTPGRCLIVSKDIITAGDGAKRNVMEGKAELSSATNAAVMQMLNDFGLK 118

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFDLFLKNDA 126
           T   + ++    L  K DM+P+E V R  A GS ++R +G++EG   +PP  + F K+D 
Sbjct: 119 TAFIKGVNKKSFLAWKCDMIPIEWVARRVATGSFIRRHVGVKEGYRFSPPKLETFYKDDE 178

Query: 127 MHDPMVNESYCETFGW------VSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
            HDP  +    E          V+ + +  M+++T    +VL+K +    + L+D K+EF
Sbjct: 179 NHDPQWSREVLEEAKLKCGKIVVTPDLIDIMEKMTITIFEVLEKAWKSKNVSLIDMKIEF 238

Query: 181 GLYK--GEVVLGDEFSPDGSRLW---DKETLEKMDKDRFRQ-------SLGGLIEAYEAV 228
           G+ +   E+VL D    D  R+W   DK  ++  DK  +R         +  L E Y  V
Sbjct: 239 GVRQDTNEIVLADVIDNDSWRIWPSGDKRLMK--DKQVYRNLKEVTNGDMQNLKENYTWV 296

Query: 229 ARRL 232
           + +L
Sbjct: 297 SNQL 300


>UniRef50_A9VBB9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Monosiga brevicollis RepID=A9VBB9_MONBE
          Length = 368

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 65/233 (27%), Positives = 106/233 (45%), Gaps = 16/233 (6%)

Query: 7   LYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +  GK K V+    N D ++L  ++  +AGDGAR  +   K  V N     I   L   G
Sbjct: 8   IVEGKTKVVHQHARNFDQVILVSKDRITAGDGARAHEISGKAKVANDTTCTIFEFLNSVG 67

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR----LGIEEGIELNPPLFDLF 121
           IP+       D   + KK+ M+P+ECV R  A GS ++R      + E      P  + F
Sbjct: 68  IPSHFVARSGDM-MVAKKVHMIPIECVARRVAYGSYLRRFKTPFPVTEAYRFPTPCLEFF 126

Query: 122 LKNDAMHDPMVNESYCETFGW---------VSKENLARMKELTYKANDVLKKLFDDAGLI 172
            K+DA HDP V +    +            ++ + + +M+  T    + L++ +   G  
Sbjct: 127 YKDDANHDPQVTKEQLLSNPLLLDEAKQLRLTPKYVEQMELWTRAVFETLERAWAVQGCT 186

Query: 173 LVDFKLEFGL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEA 224
           LVD K+EFG+  +G ++L D    D  R+W +     M   +F + L  + +A
Sbjct: 187 LVDMKIEFGIDMQGRLILADVIDNDAWRVWPQGDRRLMKDKQFYRELKTVTDA 239


>UniRef50_B3V647 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=uncultured marine crenarchaeote KM3-153-F8
           RepID=B3V647_9ARCH
          Length = 282

 Score = 91.3 bits (225), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 68/207 (32%), Positives = 99/207 (47%), Gaps = 21/207 (10%)

Query: 9   RGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           +GK K  Y S  NPD ++ +F +  SA D         KG     F  F    L    +P
Sbjct: 13  QGKVKAAYESPSNPDTIMFDFSDRISAFDVVIPTDIPEKGKNLRDFAKFFFDNL---DVP 69

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEE---------GIELNPPLF 118
             + + +  T+ +VKKLD++PVEC+VR    G L  R+   E           +L+ P+F
Sbjct: 70  HHLIKTVGSTKMIVKKLDVIPVECIVRGYLYGGLFDRVNNGEIEIDCDNVLATKLSEPIF 129

Query: 119 DLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA---GLILVD 175
           D   K+D   +P + ES   +   VS+E L  +K  +    D+ KK+ D A   G ++ D
Sbjct: 130 DPTTKSDIKDEP-ITESEIISQKIVSEEELNYLKNTSI---DIYKKILDMASKSGFLIAD 185

Query: 176 FKLEFGL-YKGEVVLGDEFSPDGSRLW 201
            KLEFG    G ++L D   PD  RLW
Sbjct: 186 LKLEFGKDESGNILLADSIGPDEFRLW 212


>UniRef50_B4Q3U0 GD23841 n=2 Tax=melanogaster subgroup RepID=B4Q3U0_DROSI
          Length = 413

 Score = 85.9 bits (211), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 61/204 (29%), Positives = 97/204 (47%), Gaps = 9/204 (4%)

Query: 7   LYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           L  GK K VY   ++P L +L  ++  +A DG +  +   K  ++N  N  +   L EAG
Sbjct: 15  LIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLKAHELQGKAAISNTTNGLVFRLLNEAG 74

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-RLGIEEGIELNPPLFDLFLKN 124
           I T       D   + +K  MVP+E V R  A GS +K    + EG    PP  +   K+
Sbjct: 75  IRTAYVDQCGDNAFIARKCKMVPIEWVTRRLATGSFIKINPEVPEGYRFAPPKQETCFKD 134

Query: 125 DAMHDPM-----VNESYCETFGW-VSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL 178
           D+ HDP+     +  S  E  G  +  + +  M+  +    +VL++ +      LVD K+
Sbjct: 135 DSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRHTSLVVFEVLERAWKTRNCALVDMKV 194

Query: 179 EFGLYK-GEVVLGDEFSPDGSRLW 201
           EFG+ + G ++L D    D  R+W
Sbjct: 195 EFGVDEDGNILLADIIDSDTWRIW 218


>UniRef50_Q9VK80 CG17024 n=4 Tax=melanogaster group RepID=Q9VK80_DROME
          Length = 395

 Score = 80.5 bits (197), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 60/204 (29%), Positives = 95/204 (46%), Gaps = 9/204 (4%)

Query: 7   LYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           L  GK K VY   ++P L +L  ++  +A DG    +   K  ++N  N  +   L EAG
Sbjct: 15  LIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLMAHELQGKAAISNTTNGLVFRLLNEAG 74

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-RLGIEEGIELNPPLFDLFLKN 124
           I T       D   + +K  MV +E V R  A GS +K    + EG    PP  +   K+
Sbjct: 75  IRTAYVDQCGDNAFIARKCQMVHIEWVTRRLATGSFIKLNPEVPEGYRFAPPKQETCFKD 134

Query: 125 DAMHDPM-----VNESYCETFGW-VSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL 178
           D+ HDP+     +  S  E  G  +  + +  M+  +    +VL++ +      LVD K+
Sbjct: 135 DSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRRTSLVVFEVLERAWKTKNCALVDMKV 194

Query: 179 EFGLYK-GEVVLGDEFSPDGSRLW 201
           EFG+ + G ++L D    D  R+W
Sbjct: 195 EFGVDEDGNILLADIIDSDTWRIW 218


>UniRef50_B2A872 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=cellular organisms RepID=B2A872_NATTJ
          Length = 226

 Score = 80.1 bits (196), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 59/208 (28%), Positives = 105/208 (50%), Gaps = 13/208 (6%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRN-------DTSAGDGARIEQFDRKGMVNNKFNYFIM 58
           ++Y GK K V+  E  +L VL F++       D   G    + +   KG+ +     +  
Sbjct: 3   QIYEGKTKKVFLNEKGNL-VLYFKDEVTGTGEDIDPGGNEVVGEIPEKGLSSLAVTKYFF 61

Query: 59  SKLAEAGIPTQ-MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR---LGIEEGIELN 114
             L E GIPT  ++    +    V++ + + +E + R +A GS ++R       + +E  
Sbjct: 62  DMLKEKGIPTHFIDASPEEGYMEVQQCEALGLEVICRVKAYGSFLRRYPEFTQNKELEHL 121

Query: 115 PPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILV 174
             L ++ +K+D   DP++N+      G ++ E L  MKE+T     +++   +D GL L+
Sbjct: 122 NYLVEVTVKDDERGDPLINDEALIKLGILNNEELDSMKEITKSVAKIIETELNDKGLDLI 181

Query: 175 DFKLEFGLYK-GEVVLGDEFSPDGSRLW 201
           DFKLEFG  K G++++ DE S D  R++
Sbjct: 182 DFKLEFGRVKDGKIIIIDEISGDSMRVF 209


>UniRef50_Q72UH8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Leptospira RepID=PUR7_LEPIC
          Length = 285

 Score = 78.6 bits (192), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 68/224 (30%), Positives = 98/224 (43%), Gaps = 30/224 (13%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKF------------NY 55
           Y+GK + +Y     D L+L   +  SA D    +    KG V N+             N+
Sbjct: 5   YKGKVRDIYDLG--DKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKDVPNH 62

Query: 56  FIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
            + + +    IP Q    L     LVKK   +  ECVVR   +GS  K            
Sbjct: 63  ILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAGIK 122

Query: 106 ---GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
              G +E  +L  P+F   +KND  HD  ++E   E    + KE    +KE +       
Sbjct: 123 LPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEMENR--IGKELFNILKEKSISIFLRA 180

Query: 163 KKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKET 205
            ++ D AG+IL D K EFG+  G+V+L DE  +PD SR W  +T
Sbjct: 181 SEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDT 224


>UniRef50_C1A3U9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Bacteria RepID=C1A3U9_GEMAT
          Length = 314

 Score = 75.9 bits (185), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 59/228 (25%), Positives = 102/228 (44%), Gaps = 34/228 (14%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE----- 63
           RGK + VY+ ++ D L++   +  SA D    E    KG V  +   + +++LA      
Sbjct: 18  RGKVRDVYAVDD-DRLLMVTTDRISAFDVVMHEAIPYKGAVLTQVTAWWLAQLAGMVDHH 76

Query: 64  ----------AGIPT--QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-------- 103
                     A +P+       L+    L  + D+VP+ECV+R    GS  K        
Sbjct: 77  LITAETDEIIAAVPSLAPYRDALAGRSMLTVRADVVPIECVIRGYITGSAWKEYREHGTL 136

Query: 104 -----RLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                + G++E   L+PP+F    K +  HD   N +  +    V  +  A+++ L  + 
Sbjct: 137 AGEALKAGLQESDRLDPPIFSPATKAETGHD--ENITVSKVISEVGADTAAQLESLARRI 194

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKET 205
            +  +   +  G+I+ D K EFG   G+++L DE  +PD SR W  ++
Sbjct: 195 YEYGRATAEPRGIIVADTKFEFGWRDGKLLLIDEVLTPDSSRFWPADS 242


>UniRef50_C7RD67 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=18
           Tax=Bacteria RepID=C7RD67_ANAPD
          Length = 226

 Score = 75.1 bits (183), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 61/211 (28%), Positives = 103/211 (48%), Gaps = 21/211 (9%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGA----------RIEQFDRKGMVNNKFNYF 56
           +Y GK K VY   N +  +L+F++D +  DG            +E    + +   KF Y 
Sbjct: 4   VYTGKTKDVYKL-NEEEYLLKFKDDVTGNDGVFDPGANSVGLTMEGAGHQAVAMTKFFY- 61

Query: 57  IMSKLAEAGIPTQ-MERLLSDTECLVKKLDMVP--VECVVRNRAAGSLVKRLG--IEEGI 111
              KL + G+ T  +   L   E +VKK ++    VE +VR  A GS ++R G  IE G 
Sbjct: 62  --EKLNDKGLTTHFISADLDKNEAIVKKAEVFGQGVEVIVRYYAVGSFIRRYGKYIESGT 119

Query: 112 ELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGL 171
           +++P + ++ LK+D   DP++ +      G +++E    +K+L     +++++      L
Sbjct: 120 KIDPYV-EITLKDDEREDPLITKDALVLLGIMTEEEYEELKDLALNIGEIVREELGKKDL 178

Query: 172 ILVDFKLEFG-LYKGEVVLGDEFSPDGSRLW 201
            L D K EFG +  G+V L DE S    R +
Sbjct: 179 DLYDIKFEFGRIEDGKVALIDEISGGNMRAY 209


>UniRef50_C5A6A8 Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase
           (PurC) n=1 Tax=Thermococcus gammatolerans EJ3
           RepID=C5A6A8_THEGJ
          Length = 219

 Score = 73.2 bits (178), Expect = 7e-12,   Method: Compositional matrix adjust.
 Identities = 60/201 (29%), Positives = 93/201 (46%), Gaps = 9/201 (4%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGAR-------IEQFDRKGMVNNKFNYFIMS 59
           +Y GK K VY  E+   LV  F++     DG         I +   KG +  +   F   
Sbjct: 4   VYSGKTKDVY--EDGPYLVFHFKDTVLGRDGREDSGGNEVIGEKTGKGSLVLEQTEFFFR 61

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L   G+ T     +   +    + + +P+E + R  A GS ++R            + +
Sbjct: 62  LLEGNGVKTHFVERIDGRKARFLRAEKIPLEVIYRELAYGSFLRRYKGWAKPFQRLGIVE 121

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
             LK+D++ DP++ E      G  S+E +  MKE T K   +L++ F   GL LVDFKLE
Sbjct: 122 FTLKDDSLDDPLIAEEAIVVLGIASEEEVEVMKEKTRKVAGILREFFSSKGLQLVDFKLE 181

Query: 180 FGLYKGEVVLGDEFSPDGSRL 200
           FG   GE+++ DE S D  R+
Sbjct: 182 FGRLDGELIVIDELSRDTMRV 202


>UniRef50_C6CV28 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=4
           Tax=Bacillales RepID=C6CV28_PAESJ
          Length = 299

 Score = 73.2 bits (178), Expect = 8e-12,   Method: Compositional matrix adjust.
 Identities = 71/247 (28%), Positives = 109/247 (44%), Gaps = 37/247 (14%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG- 65
           LY+GK + +Y      L+V+  R   SA D        +KG V N+ + F   + A+   
Sbjct: 20  LYKGKVRELYDLGEHYLIVVTDR--ISAFDYVLDPAVPQKGNVLNRLSAFWFEQTADIQT 77

Query: 66  ---IPTQMERL---------LSDTECLVKKLDMVPVECVVRNRAAG---------SLVKR 104
              + T +E+L         L D   + KK + + +ECVVR    G         S +  
Sbjct: 78  NHVVHTDVEKLGDIVTAPELLKDRIMVTKKAERIDIECVVRGYITGGGWRQYQQTSAING 137

Query: 105 LGIEEGIELN----PPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
           + + EG+  N     P+F    KND  HD  +     +    V  E    +K  + K  +
Sbjct: 138 IQLPEGMRKNERFPQPIFTPAAKNDVGHDEDIPFERMQEM--VGAELAEELKGRSIKLYE 195

Query: 161 VLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKET------LEKMDKDR 213
              +     G+IL D K EFGL  G+V+L DE F+PD SR W +++      ++ MDK+ 
Sbjct: 196 FAHEYCAKHGIILADCKFEFGLIDGKVILIDEIFTPDSSRFWGEKSYAYDIEIDSMDKEP 255

Query: 214 FRQSLGG 220
            R  L G
Sbjct: 256 VRTYLLG 262


>UniRef50_Q47KH4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=226
           Tax=Bacteria RepID=PUR7_THEFY
          Length = 307

 Score = 72.4 bits (176), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 66/229 (28%), Positives = 110/229 (48%), Gaps = 37/229 (16%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L+ GK + +Y+TE+ +L+++   +  SA D     +   KG +  + + +   +L++ 
Sbjct: 17  THLHTGKVRDLYATESGELVMVA-SDRVSAFDWVLPTEIPDKGRLLTQLSLWWFDQLSD- 74

Query: 65  GIPTQMERLLSDTE------------CLVKKLDMVPVECVVRNRAAGSLVK--------- 103
                   ++SDT              + ++LDMVPVECV R    GS +          
Sbjct: 75  ---IIDNHVISDTPPPGAPDDWAGRTLVCRRLDMVPVECVARGYLTGSGLAEYTATGAVC 131

Query: 104 --RL--GIEEGIELNPPLFDLFLKND-AMHDPMVN-ESYCETFGWVSKENLARMKELTYK 157
             RL  G+ +G  L+PP+F    K +   HD  V+ E+  E  G    E   R++E+T  
Sbjct: 132 GVRLPEGLVDGSRLDPPIFTPATKAEVGEHDENVSLETVAERHGPALAE---RLREVTLA 188

Query: 158 ANDVLKKLFDDAGLILVDFKLEFGL-YKGEVVLGDE-FSPDGSRLWDKE 204
             +  +++ ++ G++L D K EFG    G +VL DE  +PD SR W KE
Sbjct: 189 LYERGREIAEERGILLADTKFEFGWDSDGSLVLADEVLTPDSSRFWPKE 237


>UniRef50_Q9P9D8 SAICAR synthase n=1 Tax=uncultured marine group II euryarchaeote
           37F11 RepID=Q9P9D8_9EURY
          Length = 301

 Score = 71.6 bits (174), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 64/231 (27%), Positives = 105/231 (45%), Gaps = 33/231 (14%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LY+GK K V+ST++PD+L   F N  S  D        RKG   N+        + + G+
Sbjct: 5   LYQGKVKQVWSTDDPDILEFRFTNQISVFDQIIPSLIPRKGESLNRTTAHWFKLVEQEGV 64

Query: 67  -PTQMERLLSDTECLVKKLDM---------------VPVECVVRNRAAGSLVKR------ 104
             T +  L +   CLV+K+++               VP+E +VR+  +GS  +R      
Sbjct: 65  CGTHLVELNAPDRCLVRKVEVVKEPGAIPRDAEWVFVPLEFIVRHYLSGSAWRRFQRGEL 124

Query: 105 ----LGI----EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTY 156
               LG+    E G++L+ P  ++  K +A  D  ++         ++ +    + +   
Sbjct: 125 TAESLGVSQDAEYGVKLSEPFVEVTTKFEAF-DRNIDREEALQISNITDQEFDSIVQAAL 183

Query: 157 KANDVLKKLFDDAGLILVDFKLEFGLYKG-EVVLGDEFSP-DGSRLWDKET 205
           K ++++++     GLI VD K EF L  G +VVL D F   D  R WD E 
Sbjct: 184 KVDEIIEREAAKNGLIHVDGKKEFALGPGRKVVLVDTFGTLDEDRWWDAEA 234


>UniRef50_Q67KF6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Symbiobacterium thermophilum RepID=Q67KF6_SYMTH
          Length = 299

 Score = 71.2 bits (173), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 72/244 (29%), Positives = 105/244 (43%), Gaps = 40/244 (16%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKF------------- 53
           L+RGK + ++  +  D L++   +  SA D    +    KG V  +              
Sbjct: 9   LHRGKVREMFELDA-DRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHIVA 67

Query: 54  NYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-------- 105
           N+ +   L   G+P  + RLL     +V++   + VECVVR   AGS  K          
Sbjct: 68  NHLVSDDLGGLGLPGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTVCG 127

Query: 106 -----GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELT-YK-A 158
                G+     L  P+F   LKND  HD  V E+        +  +  + K L  Y+ A
Sbjct: 128 IPLPAGLRLSSRLPEPIFTPALKNDRGHDENVPEAEVRRRLGDAVTDFIKEKSLALYRYA 187

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLW------DKETLEKMDK 211
             V +K    AG+IL D K EFG    E+VL DE F+PD SR W      + E ++ +DK
Sbjct: 188 AGVAEK----AGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDSLDK 243

Query: 212 DRFR 215
              R
Sbjct: 244 QPVR 247


>UniRef50_B2KCE9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Elusimicrobium minutum Pei191 RepID=PUR7_ELUMP
          Length = 292

 Score = 68.9 bits (167), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 68/235 (28%), Positives = 94/235 (40%), Gaps = 52/235 (22%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L +GK + VY      L+V   R   S  D     Q   KG +  + + F  +K     +
Sbjct: 11  LKKGKVRDVYDAGKMLLIVASDR--VSVFDCVLPSQIPDKGKILTQISNFWFAKTISI-V 67

Query: 67  PTQM-----------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
           P  M                  +  S    LVKK + +  ECVVR    GS  K      
Sbjct: 68  PNHMISSDINEINIILKLGLDPQYYSGRTVLVKKCERIDFECVVRGYITGSAWKEYQKSG 127

Query: 106 ---------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARM-KELT 155
                    G++E  +   P+F    K D  HD  V+ +Y           L+ M K L 
Sbjct: 128 TVCGEKIKEGLKEAQKFPEPIFTPASKADTGHDENVSFAYM----------LSHMDKNLA 177

Query: 156 YKANDVLKKLFD-------DAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWD 202
           YK  D   KL++       + G+IL D K EFGL  G+++L DE  +PD SR WD
Sbjct: 178 YKIKDTSIKLYNFAEEYLKNCGIILADTKFEFGLIDGDLILIDEILTPDSSRFWD 232


>UniRef50_C6BVA6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=23
           Tax=cellular organisms RepID=PUR7_DESAD
          Length = 299

 Score = 68.6 bits (166), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 67/232 (28%), Positives = 97/232 (41%), Gaps = 36/232 (15%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L RGK + +Y  ++ D L+L   +  SA D       D KG + N+   F M    +  I
Sbjct: 16  LSRGKVRDIYEVDD-DKLLLVTTDRISAYDVIMPNPIDDKGKILNQITLFWMDMFKDI-I 73

Query: 67  PTQM---------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------ 105
           P  +                  L     LVKK   +P+EC+VR    GS  K        
Sbjct: 74  PNHLIASKVDDYPEVLHKYRDQLEGRSVLVKKAKPLPIECIVRGYITGSGWKDYQKTGEV 133

Query: 106 -------GIEEGIELNPPLFDLFLKND-AMHDPMVN-ESYCETFGWVSKENLARMKELTY 156
                  G++E   L  PLF    K +   HD  ++ E   E  G   KE   +++E T 
Sbjct: 134 CGHKLPEGLKESEMLEQPLFTPSTKAELGEHDENISVEKATEMLG---KELFDKVQEATL 190

Query: 157 KANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE 207
                 +    + G+I+ D K EFG+Y GE+++ DE  +PD SR W  E  E
Sbjct: 191 SIYKRGRDYAREKGIIIADTKFEFGIYDGELIIIDEVLTPDSSRFWPVEGYE 242


>UniRef50_B5GT63 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Streptomyces clavuligerus ATCC 27064
           RepID=B5GT63_STRCL
          Length = 345

 Score = 68.6 bits (166), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 65/230 (28%), Positives = 98/230 (42%), Gaps = 35/230 (15%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA- 64
            L+ GK + +Y  E  DL+++   +  SA D     +   KG V  + + +   +LA+  
Sbjct: 18  HLHTGKVRDLYRNEAGDLIMVA-SDRISAYDWVLPSEIPDKGRVLTRLSLWWFDRLADLV 76

Query: 65  -----------GIPTQME-RLLSDTECLVKKLDMVPVECVVRNRAAGS------------ 100
                      G P   E R L     + + L MVPVECV R    GS            
Sbjct: 77  PHHVVSTDLPDGAPADWEGRTL-----VCRSLRMVPVECVARGYLTGSGLVEYDESRTVC 131

Query: 101 -LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAN 159
            +    G+ +G EL  P+F    K  A+ D   N +Y E    V  E  A +++ T    
Sbjct: 132 GITLPEGLSDGSELPAPIFTPATKA-AVGDHDENVTYEEVARQVGAETAAVLRQTTLAVY 190

Query: 160 DVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDKETLE 207
              + +  D G+IL D K EFG  + G +V+ DE  +PD SR W   + +
Sbjct: 191 GRARDIARDRGIILADTKFEFGHTEDGTLVIADEVLTPDSSRFWPAASWQ 240


>UniRef50_UPI0001926A10 PREDICTED: similar to phosphoribosylaminoimidazole carboxylase,
           phosphoribosylaminoimidazole succinocarboxamide
           synthetase isoform 2 n=1 Tax=Hydra magnipapillata
           RepID=UPI0001926A10
          Length = 391

 Score = 68.6 bits (166), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 51/161 (31%), Positives = 76/161 (47%), Gaps = 34/161 (21%)

Query: 78  ECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFDLFLKNDAMHDPMVNESY 136
           EC+V++  M+P+E V R  A GS +KR  G+ EG   + P  + F K+DA HDP      
Sbjct: 53  ECIVERCQMIPLEIVSRRLATGSYLKRNPGVNEGFRFSTPKMEYFFKDDANHDPQ----- 107

Query: 137 CETFGWVSKENLAR-------------MKELTYKAN---DVLKKLFDDAGLILVDFKLEF 180
                W S + L               + E+T  A    ++L+K +     +LVD K+EF
Sbjct: 108 -----WSSDQILENKLMIGGLTIGQFELDEITLVAKTCFEILEKAWASRNCVLVDMKVEF 162

Query: 181 G--LYKGEVVLGDEFSPDGSRLW---DKETLEKMDKDRFRQ 216
           G  +   E+VL D    D  R+W   DK  ++  DK  +R 
Sbjct: 163 GVTIKNKEIVLADVIDNDSWRIWPAGDKRLMK--DKQVYRN 201


>UniRef50_B3DVV2 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
           n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DVV2_METI4
          Length = 297

 Score = 67.0 bits (162), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 71/233 (30%), Positives = 99/233 (42%), Gaps = 41/233 (17%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKF--------NYFIMSKL 61
           GK + +Y  +N   +V   R   SA D    E+   KG+V N+         +    S L
Sbjct: 18  GKVRDLYHWKNELWMVTSDR--VSAFDCVLAEEIPSKGIVLNQIALGWFERTSVICPSAL 75

Query: 62  AEAGIPTQME------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
               +P +++      RL+    C     D +PVE + R    G   K            
Sbjct: 76  LSEELPLEIDLPEWEGRLMRVLPC-----DPLPVEFIARGYVVGGAWKEYLEKGTAGGYK 130

Query: 106 ---GIEEGIELNPPLFDLFLKNDAMHD-PMVNESYCETFGWVSKENLARMKELTYKANDV 161
              G+  G  L  PLF    K    HD P+  ES  E  G    EN   +K LT +    
Sbjct: 131 LPRGLTYGSPLPEPLFTPTTKAKQGHDLPLDEESAKEIIG----ENYELLKNLTLELYLH 186

Query: 162 LKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDR 213
            K    + GLIL+D K EFG+ +G++ L DE  +PD SR W +E  E+ DKDR
Sbjct: 187 GKSYAFNKGLILLDTKFEFGIREGKIFLIDELMTPDSSRFWLREDFER-DKDR 238


>UniRef50_C4FB69 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Collinsella intestinalis DSM 13280
           RepID=C4FB69_9ACTN
          Length = 322

 Score = 67.0 bits (162), Expect = 5e-10,   Method: Compositional matrix adjust.
 Identities = 66/232 (28%), Positives = 101/232 (43%), Gaps = 39/232 (16%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y   +  L+V   R   SA D    ++   KG V ++ + F   KLA+  +P 
Sbjct: 25  QGKVRDIYDAGDSLLMVASDR--ISAFDYILPDEIPYKGEVLSRISAFWFEKLADV-VPN 81

Query: 69  QM---------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-------- 105
            +               E  LS    LV+K + + +ECVVR    GS+ +          
Sbjct: 82  HLVSMDPRDFPAEFLPYEEYLSGRAMLVRKAEPIKIECVVRGYLTGSIKEAYDATGEVDG 141

Query: 106 -----GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYC-ETFGWVSKENLA-RMKELTYK 157
                G+ E   L  PLF    K D   HD  ++   C E  G    E+LA ++++L+  
Sbjct: 142 IALPAGLVEASPLPEPLFTPSTKADVGDHDENISYERCVELIG----EDLASQIRDLSIS 197

Query: 158 ANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEK 208
                 +     G+I+ D K EFG+  G V L DE  +PD SR WD  + E+
Sbjct: 198 LYTEAARYARTRGIIIADTKFEFGIIDGRVTLIDECLTPDSSRFWDAASYEE 249


>UniRef50_Q313T8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Desulfovibrionaceae RepID=Q313T8_DESDG
          Length = 298

 Score = 66.2 bits (160), Expect = 8e-10,   Method: Compositional matrix adjust.
 Identities = 60/224 (26%), Positives = 95/224 (42%), Gaps = 32/224 (14%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE--- 63
           L RGK + +Y  +   LL++   +  SA D    E    KG++ N    F M + A+   
Sbjct: 15  LSRGKVRDIYEVDAETLLIVT-TDRMSAFDVIMGEPIPYKGVILNSITLFWMERFADLVP 73

Query: 64  --------AGIPTQMER---LLSDTECLVKKLDMVPVECVVRNRAAGSLVK--------- 103
                      P  + +   +L     LV+K   +PVEC+VR    GS  K         
Sbjct: 74  NHLIASDVKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITGSGWKDYQKTGMVC 133

Query: 104 ----RLGIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                 G+ E  +L  PLF    K +   HD  ++         V  +  A+++ L+ + 
Sbjct: 134 GHSLPAGLVESAKLETPLFTPSTKAELGEHDENISVQRAREL--VGDDVAAQIERLSIEI 191

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLW 201
               ++  +  G+I+ D K EFG+  G V+L DE  +PD SR W
Sbjct: 192 FSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFW 235


>UniRef50_B0VH32 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Candidatus Cloacamonas acidaminovorans
           RepID=B0VH32_9BACT
          Length = 293

 Score = 63.2 bits (152), Expect = 7e-09,   Method: Compositional matrix adjust.
 Identities = 57/173 (32%), Positives = 79/173 (45%), Gaps = 25/173 (14%)

Query: 54  NYFIMSKLAEAGIPTQ-MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG------ 106
           N+FI + ++E  +  Q     L +   LVKK  ++P E +VR   +GS  K         
Sbjct: 72  NHFITANISEYPVELQPFGEYLEERSMLVKKTRVIPFEFIVRGYLSGSAWKEYKKSNTIG 131

Query: 107 -------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMK----ELT 155
                  ++E  +   PLF    K +  HD   N SY E    + +     +K    EL 
Sbjct: 132 GMLIAEEMQESQKFPHPLFTPSTKAENGHDE--NISYREFMSRMDESLAVYIKDKSLELY 189

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE 207
             A+D+L K     G+IL D K EFG    EV+L DE F+PD SRLW  E  E
Sbjct: 190 SYAHDLLLK----KGIILADTKFEFGTIGSEVLLIDELFTPDSSRLWSLEDYE 238


>UniRef50_A8ZVI6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=15
           Tax=Bacteria RepID=PUR7_DESOH
          Length = 293

 Score = 61.6 bits (148), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 65/227 (28%), Positives = 97/227 (42%), Gaps = 33/227 (14%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFR--------NDTSAGDGARIEQ-----FDR-KGMVNNK 52
           L RGK + VY   +  L+V   R         D   G G  + Q     FD+ K +V N 
Sbjct: 16  LKRGKVRDVYDFGDRLLIVATDRLSAFDVVMPDPIPGKGEILTQISLFWFDQVKDIVRNH 75

Query: 53  FNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------- 105
                ++   EA  P      L+    LV K + + +ECVVR   +GS  K         
Sbjct: 76  LISSDVNDYPEACRP--YAETLAGRSMLVTKTEPLAIECVVRGYLSGSGWKSYQKDRTVC 133

Query: 106 ------GIEEGIELNPPLFDLFLKNDA-MHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                 G+ E   L  P+F    K +A  HD  +N S+ E      +E   + ++L+   
Sbjct: 134 GISLPDGLRESDRLPEPIFTPSTKAEAGQHD--INISFDEAANIAGRETTEKARDLSLAI 191

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKE 204
                ++ D  G+I+ D K EFG   GE++L DE  +PD SR W ++
Sbjct: 192 YRRGVEVADARGIIIADTKFEFGFVDGELILIDEVLTPDSSRFWPRD 238


>UniRef50_B8J393 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=3
           Tax=Proteobacteria RepID=B8J393_DESDA
          Length = 234

 Score = 61.2 bits (147), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 64/232 (27%), Positives = 101/232 (43%), Gaps = 23/232 (9%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNK---------FNYFI 57
           +YRGK K VY     D L L F +  +      I+        N +             I
Sbjct: 4   VYRGKTKDVYDN-GEDGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMASAI 62

Query: 58  MSKLAEA-GIPTQMERL-LSDTECLVKKLDMV--PVECVVRNRAAGSLVKRLG----IEE 109
             +LAE  G+ T M    L      V++  M    +E + R    GS ++R G    + +
Sbjct: 63  FEELAEKNGVSTHMIAYDLPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGVYD 122

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
           G+    P+F++ LK+DA  DP+V  S     G V    +  + +   KA   ++ +F   
Sbjct: 123 GMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDARTMTALLDSNAKAMQAIQAMFAAR 182

Query: 170 GLILVDFKLEFGL-YKGEVVLGDEFSPDGSRLWDKETLEKMD----KDRFRQ 216
            L L D K+E+ L  KG  +L DE SP   R +D +T +++      +RFR+
Sbjct: 183 DLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR 234


>UniRef50_A7H9G3 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=5
           Tax=Myxococcaceae RepID=A7H9G3_ANADF
          Length = 320

 Score = 61.2 bits (147), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 68/247 (27%), Positives = 105/247 (42%), Gaps = 44/247 (17%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            ELYRGK +  YS    D +V+   +  SA D   +     KG V ++   F   K+ + 
Sbjct: 24  GELYRGKVRDNYS--RGDRIVMVTTDRVSAFDHV-LGTIPFKGEVLSRLTAFWFEKVKDV 80

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEG 110
             PT +  L   +  +VK+   +P+E V+R    GSL +                G+ + 
Sbjct: 81  A-PTHVVDLPDPSVMVVKRAKPLPIEIVIRGYITGSLWRDYQAGKAGAYGIEWPKGLRKD 139

Query: 111 IELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
              + P+     K +   HD  ++E    + G V+ E       L  +A  V ++LF   
Sbjct: 140 QRFDRPIITPSTKAEYGKHDEPISEQELLSQGLVAPE-------LWREATAVAERLFARG 192

Query: 170 -------GLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK----------MDK 211
                  GLILVD K E G+  G++V+ DE  +PD SR W  +  E           +DK
Sbjct: 193 QEWALSRGLILVDTKYEMGVVDGKLVVIDEIHTPDSSRYWVADGYEDRFARGAEQEMLDK 252

Query: 212 DRFRQSL 218
           +  RQ L
Sbjct: 253 ENIRQWL 259


>UniRef50_Q3Z881 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z881_DEHE1
          Length = 304

 Score = 60.8 bits (146), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 65/212 (30%), Positives = 87/212 (41%), Gaps = 49/212 (23%)

Query: 39  RIEQFD--------RKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLD----- 85
           RI  FD         KG V N+ + F   K A   IP  +  L+ D  CL K L      
Sbjct: 39  RISAFDVILPGGIPGKGRVLNRISSFWFEKTARI-IPNHVIELVEDVSCLDKYLPPEERF 97

Query: 86  -----------------MVPVECVVRNRAAGSL---VKRLGIEEGI----------ELNP 115
                             V VECVVR   AGS     K+ G   G+          EL  
Sbjct: 98  RYPEYLSGRSMVVKRVKRVSVECVVRGYIAGSAWSEYKKTGTVNGMPMPKGLLQSQELPE 157

Query: 116 PLFDLFLKNDAMHD-PMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILV 174
           P+F    K +  HD PM   +  E    V KE   ++ E +     + ++     G+I+ 
Sbjct: 158 PIFTPTTKGEGEHDHPM---TIAELEAMVGKELADKLAEKSLALYKLGREYARQRGIIIA 214

Query: 175 DFKLEFGLYKGEVVLGDE-FSPDGSRLWDKET 205
           D K EFGL   E++L DE  +PD SR WD++T
Sbjct: 215 DTKFEFGLDGSELILIDEALTPDSSRFWDEKT 246


>UniRef50_Q895U7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=cellular organisms RepID=PUR7_CLOTE
          Length = 227

 Score = 60.5 bits (145), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 60/225 (26%), Positives = 103/225 (45%), Gaps = 21/225 (9%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNN-------KFNYFIMS 59
           +Y+GK K V+  E+ + L L+F++D +  +G      +  G+          +       
Sbjct: 4   VYKGKTKDVFLLEDGNYL-LKFKDDVTGENGVFDPGANSVGLTMEGAGRAALRLTKLFFE 62

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPV-----ECVVRNRAAGSLVKRLGI--EEGIE 112
           +L E  IPT    + S+ E    K+    +     E + R RA GS ++R G+  +EG  
Sbjct: 63  RLKEEKIPTHY--IDSNVEEGTMKVKPAKIFGNGLEVICRYRAVGSFMRRYGMYAKEGQV 120

Query: 113 LNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLI 172
           L+    ++ LK+D   DP + +   +  G +S      +K+LT K + ++K      G+ 
Sbjct: 121 LDA-FVEVTLKDDERQDPPITKDALDMLGILSLREYDILKDLTKKISGIVKDELSKKGIE 179

Query: 173 LVDFKLEFGLY--KGEVVLGDEFSPDGSRLW-DKETLEKMDKDRF 214
           L D KLEFG       + L DE S    R + D E +E +D ++ 
Sbjct: 180 LYDIKLEFGRIDEDNHIALIDEISGGNMRAYKDGEYIEPLDLEKL 224


>UniRef50_A8M140 SAICAR synthetase n=1 Tax=Salinispora arenicola CNS-205
           RepID=A8M140_SALAI
          Length = 236

 Score = 58.9 bits (141), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 64/215 (29%), Positives = 88/215 (40%), Gaps = 22/215 (10%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           G++K V+  E P   V+E      +    R E  D    +   F  ++   LA+AG+PT 
Sbjct: 15  GRSKKVWFVE-PGRCVVEMIPSLRSFTHDRDELMDGTAELRLDFFEYVSGVLAKAGVPTV 73

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--IEEGIELNPPLFDLFLKNDAM 127
               L     L      VP E +V+NRA GS  ++     EEG    PP+     + D  
Sbjct: 74  FRERLGPITYLADYRPAVPFEVIVKNRATGSTTRKYPGLFEEGRVFAPPVVKFDYRTDPE 133

Query: 128 HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL------EFG 181
             P + E Y    G     ++   + L    N VL  L   + L L DF L      E G
Sbjct: 134 DQP-IGEDYLRRTG----VDVEAYRRLALACNTVLHTLV--SPLELWDFCLVIAPDEERG 186

Query: 182 LYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQ 216
           L     V+  E SPD  RL  +   E  DKD FR+
Sbjct: 187 L-----VINSEISPDCMRL-RRADGEPYDKDLFRR 215


>UniRef50_C7M1W2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Acidimicrobium ferrooxidans DSM 10331
           RepID=C7M1W2_ACIFD
          Length = 292

 Score = 58.5 bits (140), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 50/136 (36%), Positives = 65/136 (47%), Gaps = 20/136 (14%)

Query: 81  VKKLDMVPVECVVRNRAAGSL---VKRLGIEEGIELN----------PPLFDLFLKNDAM 127
           V++L M+PVECVVR R  GS     +R G   G EL            PLF    K    
Sbjct: 87  VRRLAMLPVECVVRGRLVGSAWESYQRDGTAFGRELPRDLDFGAPFPEPLFTPTTKAHVG 146

Query: 128 HD-PMVNESYCETFGWVSKENLAR-MKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKG 185
           HD P+  +   E  G    E  AR + + + +   +L   FD  GL LVD K EFGL   
Sbjct: 147 HDLPLGPDELGELVG----ERRARELADRSLEVFSLLASWFDAKGLTLVDAKFEFGLDGR 202

Query: 186 EVVLGDEF-SPDGSRL 200
            +VL DE  +PD +R+
Sbjct: 203 ALVLADEIATPDAARI 218


>UniRef50_Q466M0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Archaea RepID=Q466M0_METBF
          Length = 296

 Score = 58.2 bits (139), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 74/288 (25%), Positives = 112/288 (38%), Gaps = 65/288 (22%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           + +GK K +      + + LE RN  + GD AR E     G+        I S L   G+
Sbjct: 3   ISQGKTKVILPGPRKNTVFLETRNVLTGGDAARRETIAGIGIHKTTQAANIFSLLNRKGL 62

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR---LGIEEGI--ELNPPLFDLF 121
           PT      S    L  + +M+P+E VVR  A GS ++R    G +EG     + P++++F
Sbjct: 63  PTAFIERTSPNTLLCYQCEMLPLELVVRRYAWGSYLQRHPEYGNQEGTAYRFDEPVWEIF 122

Query: 122 LKNDAMHDPMVNESYC-------ETF---------------------GWV---SKENLAR 150
            K   +  P+ ++ Y        E F                      W+   SK+ L++
Sbjct: 123 HKLSVVGFPVTDKPYQIDEEAAREQFLHNGIWQEGVYTDPYIQVDKNQWLLYPSKKELSK 182

Query: 151 MK------------ELTYKAN-----------DVLKKLFDDAGLI-LVDFKLEFG--LYK 184
            K            EL Y              D  +K+    G + LVD K+E G  L  
Sbjct: 183 SKPILSMKPACSQEELDYIVQAIMLPTFLALEDAWRKIMTTYGPMELVDLKIEVGRRLDN 242

Query: 185 GEVVLGDEFSPDGSRLWDKETLEK-MDKDRFR--QSLGGLIEAYEAVA 229
             +V+ D    D  R+W     EK +DK  FR    L  + E Y  +A
Sbjct: 243 NRIVIADVIDNDSWRIWSGGNPEKQLDKQCFRDGNPLDQVAENYATLA 290


>UniRef50_Q5X4M9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=33
           Tax=cellular organisms RepID=PUR7_LEGPA
          Length = 312

 Score = 58.2 bits (139), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 59/215 (27%), Positives = 90/215 (41%), Gaps = 27/215 (12%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y+GK +  Y     D L+L   +  SA D   +     KG V N  + +   K  ++ +P
Sbjct: 16  YKGKVRDTYDLG--DQLILVTTDRQSAFDRC-LAAVPYKGQVLNLTSVWWF-KNTQSIVP 71

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------GIEEGIELNPPLFDLF 121
             +  +      + KK  + P+E VVR   +GS    L      G+ E   +  P  D  
Sbjct: 72  NHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFP--DGL 129

Query: 122 LKNDAMHDPMVNESYCETF-------------GWVSKENLARMKELTYKANDVLKKLFDD 168
            KN  +  P++  +  ET              GW+++E+         K      ++   
Sbjct: 130 RKNQKLESPVITPTTKETLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQ 189

Query: 169 AGLILVDFKLEFGL-YKGEVVLGDEF-SPDGSRLW 201
            GLILVD K EFG   +G +VL DE  +PD SR W
Sbjct: 190 HGLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYW 224


>UniRef50_A1VU36 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=19
           Tax=Bacteria RepID=PUR7_POLNA
          Length = 305

 Score = 57.4 bits (137), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 67/230 (29%), Positives = 95/230 (41%), Gaps = 33/230 (14%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L RGK +  Y+  N D L++   +  SA D    E    KG +  +   F   KL     
Sbjct: 19  LARGKVRDNYAVGN-DRLLMVASDRLSAFDVILGEPIPGKGALLTQMALFWFDKLGSI-C 76

Query: 67  PTQM-----ERLLSDTEC--------LVKKLDMVPVECVVRNRAAGS------------- 100
           P  +     E +++  E         LVK+L  +PVE VVR   AGS             
Sbjct: 77  PNHLTGEAPESVVTAAEIPQVAGRSMLVKRLKPIPVEAVVRGYLAGSGWVEYQQSQSVCG 136

Query: 101 LVKRLGIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKAN 159
           +    G++   +L  P+F    K +   HD   N SY +    V  E  A++K L+    
Sbjct: 137 VPLPAGLKNASKLPEPIFTPAAKAEVGEHD--ENISYEQVVKVVGPELAAQIKTLSIAIY 194

Query: 160 DVLKKLFDDAGLILVDFKLEFGL-YKGEVVLGDE-FSPDGSRLWDKETLE 207
           +         G+I+ D K EFGL   G + L DE  +PD SR W  E  E
Sbjct: 195 ETAAAFALTKGIIIADTKFEFGLDENGTLTLMDEVLTPDSSRYWPVEGYE 244


>UniRef50_Q7UJ19 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Rhodopirellula baltica RepID=PUR7_RHOBA
          Length = 320

 Score = 57.4 bits (137), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 44/149 (29%), Positives = 67/149 (44%), Gaps = 18/149 (12%)

Query: 80  LVKKLDMVPVECVVRNRAAGSLVKRL-------------GIEEGIELNPPLFDLFLKNDA 126
           + +K  +VP ECVVR    GS  K               G+++  +L+  +F    K + 
Sbjct: 125 VTRKASVVPFECVVRGYLEGSGWKEYQATGEVCGVSLPAGLKQCDQLSEAIFTPATKAEE 184

Query: 127 MHDPMVN-ESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKG 185
            HD  V+ E   ++ G      L RM    Y+      K+  + GL++ D K EFG+  G
Sbjct: 185 GHDENVSYEVMSQSLGEEQSSQLRRMSLAIYQD---ASKIAAERGLLIADTKFEFGVVDG 241

Query: 186 EVVLGDE-FSPDGSRLWDKETLEKMDKDR 213
           E++L DE  +PD SR W  +  E     R
Sbjct: 242 ELMLIDEVLTPDSSRFWAADEYEPGHSQR 270


>UniRef50_B5JQ22 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JQ22_9BACT
          Length = 308

 Score = 57.4 bits (137), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 59/225 (26%), Positives = 99/225 (44%), Gaps = 32/225 (14%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           ++  GK + +Y  ++  LLV   R   SA D         +G++  + ++F   +     
Sbjct: 27  KIASGKVREIYDLDDSVLLVATDR--ISAFDVVLPGGIPGRGLILTQLSHFWFEQTKHIA 84

Query: 66  ----IPTQME------RLLSDTEC---LVKKLDMVPVECVVRNRAAGS------------ 100
               +P + E      +L  D++     V+KL  + +ECVVR   AGS            
Sbjct: 85  PNHILPNEQEILAGRLQLSRDSQLRSMAVRKLQPLEIECVVRGYIAGSGWESYQKDRTVC 144

Query: 101 -LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAN 159
            +    G++   +L  P+F    K    HD  V+ S  E    V ++   ++K ++ +  
Sbjct: 145 GIELPAGLQLASQLPEPIFTPTTKASEGHDMPVSPS--EAAAIVGQDVFDQVKAISLELY 202

Query: 160 DVLKKLFDDAGLILVDFKLEFGL-YKGEVVLGDE-FSPDGSRLWD 202
           +   +L   AG+IL D K EFG    G++ L DE  +PD SR WD
Sbjct: 203 NFGSQLAAKAGIILADTKFEFGTDESGKIYLIDEVLTPDSSRYWD 247


>UniRef50_Q3CXY3 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Streptococcus agalactiae H36B RepID=Q3CXY3_STRAG
          Length = 92

 Score = 57.0 bits (136), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 26/75 (34%), Positives = 44/75 (58%)

Query: 103 KRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
           KR G+E G  L  P+ + + KND ++DP +N+ + +  G V+ E +A +K  T + N++L
Sbjct: 2   KRFGVEVGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELL 61

Query: 163 KKLFDDAGLILVDFK 177
           K  F   G+  +DF 
Sbjct: 62  KDWFAQIGITWIDFS 76


>UniRef50_P27616 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=32
           Tax=cellular organisms RepID=PUR7_YEAST
          Length = 306

 Score = 57.0 bits (136), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 49/164 (29%), Positives = 73/164 (44%), Gaps = 23/164 (14%)

Query: 56  FIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
           ++ +KL+E    TQ+E    D   LV K  ++P+E +VR    GS  K            
Sbjct: 88  YLPAKLSEPKYKTQLE----DRSLLVHKHKLIPLEVIVRGYITGSAWKEYVKTGTVHGLK 143

Query: 106 ---GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDV 161
              G++E  E   P+F    K +   HD   N S  +    V  +   R+ EL  K    
Sbjct: 144 QPQGLKESQEFPEPIFTPSTKAEQGEHDE--NISPAQAAELVGGDLSRRVAELAVKLYSK 201

Query: 162 LKKLFDDAGLILVDFKLEFGL--YKGEVVLGDE-FSPDGSRLWD 202
            K    + G+I+ D K EFG+     E++L DE  +PD SR W+
Sbjct: 202 CKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWN 245


>UniRef50_Q9HLC0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=Euryarchaeota RepID=PUR7_THEAC
          Length = 294

 Score = 55.8 bits (133), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 66/260 (25%), Positives = 113/260 (43%), Gaps = 39/260 (15%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           + +GK K VY  ++ D LV  F N  S  D     + + KG    + + F    + E GI
Sbjct: 4   IAKGKVKDVY--DDGDTLVFRFSNRISVFDKIIPTEIENKGESLCRTSSFWFRYIGERGI 61

Query: 67  PTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRL--------- 105
                 ++ +    V+K D            ++P+E + R+  AGSL  RL         
Sbjct: 62  KNHFIEMIDNRTMRVRKYDVPEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGSTKPAD 121

Query: 106 -GIEE----GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
            G+      G +L  P+F++  K +     +  +   E  G +++E  A ++E   K ++
Sbjct: 122 IGLNHFPDYGEKLPSPVFEVTTKREKTDRLLDIDEALEISG-LTREEYAEIRETILKIDE 180

Query: 161 VLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE-----KMDKDR 213
           ++++     GLI  D K E  L K  E ++ D F + D  R W+K+  +     ++ K+ 
Sbjct: 181 MMEQEVGKRGLIHADGKKEVALGKEREPIIVDTFGTADEDRFWEKKEYDAGRIVELSKEM 240

Query: 214 FRQ---SLGGLIEAYEAVAR 230
            RQ   S G     YEA +R
Sbjct: 241 VRQYYRSTGYHDRLYEARSR 260


>UniRef50_C7NLA9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Kytococcus sedentarius DSM 20547 RepID=C7NLA9_KYTSD
          Length = 336

 Score = 55.1 bits (131), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 72/259 (27%), Positives = 109/259 (42%), Gaps = 67/259 (25%)

Query: 7   LYRGKAKTVYSTENPD-----------LLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNY 55
           ++ GK + +Y+   PD           +L++   +  SA D       + KG V  + + 
Sbjct: 27  VHAGKVRELYA-PGPDAPLPGGFAADEVLLMVASDRISAYDHVLSTPIEDKGEVLTRMSL 85

Query: 56  FIMSKLAEAGIPTQM--------ERLLSDTECLVKKLDMVPVECVVRN----------RA 97
           +   +LA+  +P  +           ++    LVK+L M+PVECV R           R 
Sbjct: 86  WWFDQLADL-VPHHVLATEAPLVPEQVAGRAVLVKRLRMLPVECVARAHLTGGGLSEYRR 144

Query: 98  AGSLVK---RLGIEEGIELNPPLFDLFLKNDA-MHD-PMVNESYCETFGWVSKENLAR-M 151
           AG++     R G+ +G EL  P+F    K  A  HD P+  E    T G    E LAR  
Sbjct: 145 AGTVSGVRLREGLVDGDELPDPIFTPSTKAPAGEHDEPISYEQVVTTIG----EPLARAA 200

Query: 152 KELTYKANDVLKKLFDDA---GLILVDFKLEFGLYKGE-------------------VVL 189
           + LT     +L++  + A   G+I+ D K+EFGL   E                   +VL
Sbjct: 201 RNLTVA---ILRRGHEVAAGRGIIVADTKVEFGLEGVEAERDLRTVTQKELDAGSVRIVL 257

Query: 190 GDE-FSPDGSRLWDKETLE 207
            DE  +PD SR W  E  E
Sbjct: 258 ADEVLTPDSSRFWPAEGFE 276


>UniRef50_B3T553 Putative SAICAR synthetase n=2 Tax=prokaryotic environmental
           samples RepID=B3T553_9ZZZZ
          Length = 314

 Score = 54.7 bits (130), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 58/236 (24%), Positives = 98/236 (41%), Gaps = 35/236 (14%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           +Y GK K V+ST++PD++   + +  S  D        RKG   N+ +      + + G+
Sbjct: 16  IYHGKVKQVWSTDDPDIIEFRYTDQISVFDQIIPSLVPRKGESLNRTSCHWFELVEKEGV 75

Query: 67  -PTQMERLLSDTECLVKKLDM---------------VPVECVVRNRAAGSLVKR------ 104
             T +  + +      ++ D+               VP+E + R+  AGS  +R      
Sbjct: 76  CDTHVIEMNAPDRVRARRFDVIREAGAITPDAENVFVPLEVICRHYLAGSGWRRYARGDV 135

Query: 105 ----LGIE------EGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKEL 154
                G E      EG++L  P  ++  K +     +  E   E    +S E    + E+
Sbjct: 136 GAEEFGFEPGTVLTEGVKLPKPYLEVSTKFEKFDRLLGREEALEISN-LSDEEFDSILEI 194

Query: 155 TYKANDVLKKLFDDAGLILVDFKLEFGLYKG-EVVLGDEFSP-DGSRLWDKETLEK 208
             K ++++++    +GLI VD K EF L  G   VL D F   D  R WD    E+
Sbjct: 195 VLKVDEIIEREAAKSGLIHVDGKKEFALGVGRRPVLVDSFGTLDEDRWWDAAAYER 250


>UniRef50_B5GV74 Saicar synthetase n=1 Tax=Streptomyces clavuligerus ATCC 27064
           RepID=B5GV74_STRCL
          Length = 238

 Score = 54.3 bits (129), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 65/229 (28%), Positives = 100/229 (43%), Gaps = 14/229 (6%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           G++K ++      L V+E      +   +R E  +  G +  +F     ++LA+ G+ T 
Sbjct: 19  GRSKRIWLLSG-GLCVVEMIPSLRSFTYSRDELVEETGPLRLEFYDRAAARLAKGGVRTG 77

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAGS-LVKRLGI-EEGIELNPPLFDLFLKNDAM 127
             R L+ T  L +  +  P E VV+NRA GS LVK  G+     EL  P+     + D  
Sbjct: 78  FVRRLAPTVYLSEFHEAPPFEVVVKNRAVGSTLVKYPGLFPANSELPKPVVKFDYRIDPE 137

Query: 128 HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YKGE 186
             P + E Y        +E     + +    ND L      A L + DF +  GL  +GE
Sbjct: 138 DQP-IGEDYLRALDLPVEE----FRRIALAVNDTLISWL--APLEVWDFCIILGLDPQGE 190

Query: 187 VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGG--LIEAYEAVARRLG 233
            VL  E SPD  RL   +    +DKD FR       L+ A++ +   +G
Sbjct: 191 PVLISEVSPDCMRLRHPDG-SSLDKDLFRHGASSEELVTAWQRLLDEIG 238


>UniRef50_D0MIB5 Phosphoribosylaminoimidazolesuccinocarboxamidesy nthase n=18
           Tax=Bacteria RepID=D0MIB5_RHOM4
          Length = 328

 Score = 54.3 bits (129), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 61/227 (26%), Positives = 97/227 (42%), Gaps = 23/227 (10%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           YRGK + VY+ +    LV+   +  SA D    +    KG V N+   +     A+  +P
Sbjct: 27  YRGKVRDVYTVDG--HLVIVTTDRISAFDHILRQTIPFKGQVLNQLAAYFFRHTADL-VP 83

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSL--VKRLG--------IEEGI----EL 113
             +E +      + ++   +P+E VVR   AG    V R G        + EG+     L
Sbjct: 84  NHVEAVPDPNVTVARRCRPIPIEFVVRGYLAGHAWRVYRSGRRELCGKKLPEGLVQNARL 143

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
             P+     K    HD  ++       G +  E   R++ +T        ++    GLIL
Sbjct: 144 PEPILTPATKAKEGHDEDISREEIIARGLLDAETFDRIEVMTLALYRRGAEMAARRGLIL 203

Query: 174 VDFKLEFGL-YKGEVVLGDE-FSPDGSRLWDKETLEKMDKDRFRQSL 218
           VD K EFG+  +G + L DE  +PD SR +  +  E    +R R+ L
Sbjct: 204 VDTKYEFGIDDEGMIRLIDEVHTPDSSRYFYADEYE----ERLRKGL 246


>UniRef50_A7BA15 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Actinomyces odontolyticus ATCC 17982
           RepID=A7BA15_9ACTO
          Length = 333

 Score = 54.3 bits (129), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 53/230 (23%), Positives = 90/230 (39%), Gaps = 43/230 (18%)

Query: 16  YSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL----------AEAG 65
           ++   P+ L++   +  SA D         KG V N+   + M +L              
Sbjct: 42  HAKAGPEALLMVTSDRISAYDYVLPTLIPGKGAVLNQLAIWWMGQLRPLVENHLLAVGTK 101

Query: 66  IPTQMERLLSDTE--------------CLVKKLDMVPVECVVRNRAAGSLVKRL------ 105
            P +  R L   +               + + L M+P+ECVVR    GS +         
Sbjct: 102 APAEASRALEGAQPTRFTVPAEVDGRAVVCRSLHMIPIECVVRGYLTGSGLAEYRESGSV 161

Query: 106 -------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYK 157
                  G+ E   L  P+F    K +   HD   N ++ +T   + +E    +++L+  
Sbjct: 162 CGIKLPEGLTEASRLEEPIFTPAAKAELGEHD--ENITFEQTVERIGEELAVAIRDLSIA 219

Query: 158 ANDVLKKLFDDAGLILVDFKLEFGL--YKGEVVLGDE-FSPDGSRLWDKE 204
                + +  + G+I+ D K EFG+    G +VL DE  +PD SR W  +
Sbjct: 220 LYRAARDIAAERGIIIADTKFEFGIDVTTGALVLADEILTPDSSRFWPAD 269


>UniRef50_Q9UUB4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=59
           Tax=cellular organisms RepID=PUR7_SCHPO
          Length = 299

 Score = 53.5 bits (127), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 60/222 (27%), Positives = 86/222 (38%), Gaps = 32/222 (14%)

Query: 10  GKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYF------------ 56
           GK + +Y   E PD L+    +  SA D         KG V  K + F            
Sbjct: 18  GKVRDLYECVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKPHVQTH 77

Query: 57  -IMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
            I S+  E          L D   LVKK  ++P+E +VR    GS  K            
Sbjct: 78  LITSRWEELPPVITKHEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQGTVHGLN 137

Query: 106 ---GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
              G++E      PLF    K    HD  ++    E    V  E   ++ E + K   + 
Sbjct: 138 VPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPD--EVSKIVGPELAKQVAETSVKLYKIA 195

Query: 163 KKLFDDAGLILVDFKLEFGL--YKGEVVLGDE-FSPDGSRLW 201
           + +    G+I+ D K EFG+     ++VL DE  +PD SR W
Sbjct: 196 RDVALKKGIIIADTKFEFGVDETTNKIVLVDEVLTPDSSRFW 237


>UniRef50_Q83GX1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Tropheryma whipplei RepID=PUR7_TROWT
          Length = 305

 Score = 53.1 bits (126), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 44/161 (27%), Positives = 70/161 (43%), Gaps = 21/161 (13%)

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSL------------VKRLG-IEEG 110
           + IP+ +  L   T C  +K+D++P E V+R    GS             +K  G   +G
Sbjct: 94  SHIPSHI--LERSTIC--RKMDIIPFEFVIRGYLTGSAWADYLENNTVYGIKLKGKFRQG 149

Query: 111 IELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
             L  P+F    K+     P+  E      G    + L  M    Y   + + +   + G
Sbjct: 150 DRLPGPIFTPTTKSRTKDTPVRYEDLVNAIGLSHAQQLREMCTDYYTTAEQIAR---NKG 206

Query: 171 LILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEKMD 210
           LI+ D K EFG+ +G+V L DE  + D +R WD  +  + D
Sbjct: 207 LIIADAKFEFGIAEGKVYLADELLTADSARYWDINSWGQFD 247


>UniRef50_UPI000187DCD8 hypothetical protein MPER_11578 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DCD8
          Length = 297

 Score = 52.8 bits (125), Expect = 9e-06,   Method: Compositional matrix adjust.
 Identities = 63/229 (27%), Positives = 97/229 (42%), Gaps = 38/229 (16%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDG-------------ARIEQFDRKGMVNNKFNY 55
           +GK + +YST + D L+    +  SA D               +I  F  K + N   N+
Sbjct: 16  KGKVRNIYSTSSTDHLLFVATDRISAYDVILKNGIPDKGKLLTQISLFWFKKLGNIIPNH 75

Query: 56  FIMSKLAEAGIPTQMERL---LSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIE---- 108
           F+ + + E  +P Q+ +    L D   LV+K  ++ +E +VR    G +   LG E    
Sbjct: 76  FVTADIDE--MPEQVRKYKDQLKDRTMLVRKAKVIQIEAIVRGYLTGEIW--LGPEYQKD 131

Query: 109 EGIELNPPLFDLFLKNDAMHDPMVN-ESYCETFGWVSKENLARMK-ELTYKANDVLKKLF 166
            G  +  PL     ++   HD   + E   +  G V  + +++   EL  +A        
Sbjct: 132 RGQSMGSPLPTKHGRSKGAHDENFSPEQAVKLLGQVLYDKVSQASLELYSEAASYAH--- 188

Query: 167 DDAGLILVDFKLEFGLYKG-------EVVLGDE-FSPDGSRLWDKETLE 207
              GLIL D K EFGL          E++L DE  +PD SR W  E  E
Sbjct: 189 -SRGLILADTKFEFGLIPSTSKPGEEELILVDEVLTPDSSRYWPLEGYE 236


>UniRef50_A6LDF8 Phosphoribosylamidoimidazole-succinocarboxamide synthase n=19
           Tax=Bacteroidetes RepID=A6LDF8_PARD8
          Length = 316

 Score = 52.4 bits (124), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 64/231 (27%), Positives = 101/231 (43%), Gaps = 28/231 (12%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +Q  +Y GK + VY+  N ++LV+   +  SA D    E    KG + N+    I +K  
Sbjct: 14  RQKSVYHGKVRDVYNI-NDEVLVMVATDRISAFDVILPEGIPYKGQMLNQ----IAAKFL 68

Query: 63  EAGIPTQMERLLSDTECLVK---KLDMVPVECVVRN-------RAAGSLVKRL------- 105
           +A         ++  + +V    +    PVE +VR        RA  S V+ +       
Sbjct: 69  DATTDICPNWKMATPDPMVTVGVQCQGFPVEMIVRGYLCGSAWRAYKSGVREICGVKLPE 128

Query: 106 GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKK 164
           G+ E      P+     K +   HD  +++      G VSKE+   +++ T        +
Sbjct: 129 GMRENQRFPEPIITPTTKAEIGEHDQDISKEEILAKGLVSKEDYEVLEKYTMALFKRGTE 188

Query: 165 LFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDRF 214
           +  + GLILVD K EFG   G++ L DE  +PD SR +  E  E    DRF
Sbjct: 189 IAKERGLILVDTKYEFGHRDGKIYLIDEIHTPDSSRYFYSEGYE----DRF 235


>UniRef50_C9KPE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Mitsuokella multacida DSM 20544 RepID=C9KPE2_9FIRM
          Length = 290

 Score = 52.0 bits (123), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 66/244 (27%), Positives = 96/244 (39%), Gaps = 43/244 (17%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M++      GK + VY   +  ++V   R   SA D     Q  +KG V  + + F    
Sbjct: 1   MKEYKPFKSGKVREVYDAGDSIIMVATDR--ISAFDHILKNQITKKGKVLTQMSKFWFD- 57

Query: 61  LAEAGIPTQM---------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL 105
             +  IP  M               + L +  +C  KKL M+P+EC+VR    GS     
Sbjct: 58  FTKDIIPNHMISVDNNDMPEFFRQPQFLGNSMKC--KKLTMLPMECIVRGYITGSGWASY 115

Query: 106 -------------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMK 152
                        G++E  +L  P+F    K + + D   N S  +      KE      
Sbjct: 116 QENGTVCGIKLPEGLKESQKLPEPIFTPSTKAE-LGDHDENVSLEQGAAVFEKEFPGHGM 174

Query: 153 ELTYKANDVLKKLFDDA-------GLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDK 203
           E   K  D    ++          G+I+ D K EFGL + G +VLGDE  +PD SR W  
Sbjct: 175 EYAEKLRDYTIAIYKKCAAYALSRGIIIADTKFEFGLDEDGNIVLGDEVLTPDSSRFWPL 234

Query: 204 ETLE 207
           E  E
Sbjct: 235 EGYE 238


>UniRef50_UPI00015FF598 UPI00015FF598 related cluster n=1 Tax=Drosophila melanogaster
           RepID=UPI00015FF598
          Length = 183

 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 31/97 (31%), Positives = 47/97 (48%), Gaps = 1/97 (1%)

Query: 7   LYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +  GK K VY   E P L +L  ++  +AGDG +      K  ++N  N  ++  L EAG
Sbjct: 11  IIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVVRLLNEAG 70

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLV 102
           I T   +       + +K  M+P+E V R  A GS +
Sbjct: 71  IRTAYVKQCGAKSFIARKCQMIPIEWVTRRLATGSSI 107


>UniRef50_A8LCN0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacteria RepID=A8LCN0_FRASN
          Length = 354

 Score = 52.0 bits (123), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 45/138 (32%), Positives = 62/138 (44%), Gaps = 18/138 (13%)

Query: 80  LVKKLDMVPVECVVRNRAAGSLVK-------------RLGIEEGIELNPPLFDLFLKND- 125
           L ++LDMV +ECV R    GS +K               G+E+G  L  P++    K   
Sbjct: 151 LCRRLDMVQIECVARGYLTGSGLKDYRRSGTVSGHPLPAGLEDGSRLPNPIYTPSTKAPI 210

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL-YK 184
             HD   N S  +  G V  E  A ++ LT +       L  + G++L D K EFG    
Sbjct: 211 GEHD--ENISRDDAAGRVGAELAAELERLTLQIFGRASDLAAERGILLADTKFEFGHDAD 268

Query: 185 GEVVLGDE-FSPDGSRLW 201
           G + L DE  +PD SR W
Sbjct: 269 GVLRLADEVLTPDSSRFW 286


>UniRef50_UPI000038E095 phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E095
          Length = 296

 Score = 50.8 bits (120), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 60/229 (26%), Positives = 95/229 (41%), Gaps = 31/229 (13%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L +GK K VY  ++   LV +F +  S  D    +    KG    + + +  + ++  GI
Sbjct: 6   LRKGKVKDVY--DDGKDLVFKFSDRISVFDKIIPDSIPHKGESLCRTSTYWYNIVSSLGI 63

Query: 67  PTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRLGIEE----- 109
            T    L+SD+E  VKK              MVP+E + R   AGS   R+   E     
Sbjct: 64  DTDFIELVSDSEMKVKKFRQIDRGYKFLSNYMVPLEFITRYYLAGSAYDRVKSGEIDYHS 123

Query: 110 ---------GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
                    G +L  P F++  K +     +  +   E  G  + E L  ++E  +K + 
Sbjct: 124 LGFKNPPVYGEKLPDPFFEVSTKFEKFDRYLHTDEALEISGLDAGE-LCEIQETIFKIDR 182

Query: 161 VLKKLFDDAGLILVDFKLEF--GLYKGEVVLGDEFSPDGSRLWDKETLE 207
            +    +  GLI  D K EF  GL +  V++    + D  R WDK+  E
Sbjct: 183 RINSSVESRGLIHADGKKEFALGLERKPVIIDTFGTLDEDRFWDKKDYE 231


>UniRef50_Q5P7J7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=216
           Tax=cellular organisms RepID=PUR7_AZOSE
          Length = 311

 Score = 50.4 bits (119), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 68/243 (27%), Positives = 106/243 (43%), Gaps = 49/243 (20%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L RGK + +Y+ +   LL++   +  SA D    +    KG V      F  ++L    +
Sbjct: 16  LGRGKVRDIYAVDADKLLIVT-SDRLSAFDVILPDPIPDKGRVLTAMAAFWFARLGHI-V 73

Query: 67  PTQM-----ERLLSDTE--------CLVKKLDMVPVECVVRNRAAGSLVK---------- 103
           P Q+     E +++  E         +VK+L  +P+E VVR    GS  K          
Sbjct: 74  PNQLTGIDPESVVASDERDQVRGRSLVVKRLKPLPIEAVVRGYVIGSGWKDYQDTGAICG 133

Query: 104 -RL--GIEEGIELNPPLFDLFLKNDAM-HDPMVN----ESYC--ETFGWV--SKENLARM 151
            RL  G+ +  +L  P+F    K D   HD  ++    ++ C  E  G +  S  N AR 
Sbjct: 134 IRLPAGLAQAAKLPSPIFTPASKADVGDHDENISFAAAQTRCAAELTGLLAGSGTNGAR- 192

Query: 152 KELTYKANDVLKKLFDDA-------GLILVDFKLEFGL-YKGEVVLGDE-FSPDGSRLWD 202
             L  +A D    L+ +A       G+I+ D K EFG+   G + L DE  +PD SR W 
Sbjct: 193 --LATEARDAAITLYVEAANYAAGRGIIIADTKFEFGIDSAGTLHLIDEALTPDSSRFWP 250

Query: 203 KET 205
            ++
Sbjct: 251 ADS 253


>UniRef50_A6GYJ4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=22
           Tax=Bacteroidetes RepID=PUR7_FLAPJ
          Length = 316

 Score = 50.4 bits (119), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 61/218 (27%), Positives = 96/218 (44%), Gaps = 19/218 (8%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           Q  +YRGK + VY+  N +LLV+   +  SA D    E    KG + N+     M +L +
Sbjct: 14  QKSVYRGKVREVYNI-NDELLVMVATDRLSAFDVVLPEGIPYKGQILNQIATKFM-ELTQ 71

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAG------SLVKRL--------GIEE 109
             +P  +         +    +   VE V+R   +G      +L KR         G++E
Sbjct: 72  DIVPNWLIATPDPNVAVGHLCEPFKVEMVIRGYLSGHAAREYALGKRTICGVTMPEGLKE 131

Query: 110 GIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDD 168
             +   P+     K D   HD  ++ S       VS+++   +++ T        ++   
Sbjct: 132 NDQFPTPIITPTTKADNGSHDEDISRSAILAKNIVSEQDYLVLEKYTRDLYQRGTEIAAS 191

Query: 169 AGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKE 204
            GLILVD K EFG  K G++VL DE  +PD SR +  E
Sbjct: 192 RGLILVDTKYEFGKTKDGKIVLIDEIHTPDSSRYFYAE 229


>UniRef50_Q11TT6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=13
           Tax=Bacteria RepID=PUR7_CYTH3
          Length = 310

 Score = 50.1 bits (118), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 54/213 (25%), Positives = 90/213 (42%), Gaps = 18/213 (8%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           Q   Y+GK + VY     D LV+   +  SA D         KG V N+    ++++ A+
Sbjct: 14  QTGFYKGKVRDVYYVA--DKLVVVASDRISAFDVVLPRAIPFKGQVLNQIAAKMLAQTAD 71

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--------------IEE 109
             +P  +  +   +  +  K +   VE V+R   AG   +                 ++E
Sbjct: 72  V-VPNWILSVPDPSVSIGIKCEPFKVEMVIRGYLAGHAAREYKAGKRTLCGVALPEELKE 130

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +L  P+     K D  HD  ++       G VS+ +  ++++ T        +L +  
Sbjct: 131 NDKLPAPIITPTTKADEGHDEDISREDLLARGIVSEADYIQLEKYTQALFQRGTELAEKQ 190

Query: 170 GLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLW 201
           GLILVD K EFG    ++ L DE  +PD SR +
Sbjct: 191 GLILVDTKYEFGKVGDKIYLIDEIHTPDSSRYF 223


>UniRef50_B7FS23 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacillariophyta RepID=B7FS23_PHATR
          Length = 562

 Score = 49.7 bits (117), Expect = 8e-05,   Method: Compositional matrix adjust.
 Identities = 58/220 (26%), Positives = 88/220 (40%), Gaps = 24/220 (10%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           RGK +  Y       LV     D  +G    + +   KG V N  + F   + A   IP 
Sbjct: 268 RGKVRDRYPGTKSLALVT---TDRQSGFDRMLARVPYKGAVLNLTSAFWFEQTAHI-IPN 323

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--GIEEGIE--LNPPLFDLFLKN 124
            +  +      +VK     P+E VVR+   GS    +    +EG+       L D   KN
Sbjct: 324 HLVSVPHPYVSVVKPCQPFPIEFVVRSYMTGSTSTSIWRNYQEGVRSYCGHDLPDGMTKN 383

Query: 125 DAM-------------HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGL 171
             +             HD  ++        W+++ +L        K   + +++    GL
Sbjct: 384 QKLECNILTPTTKEEDHDRPISLVDIVAENWMTQSDLDVCAAAALKVFALGQQVAAAHGL 443

Query: 172 ILVDFKLEFGL--YKGEVVLGDE-FSPDGSRLWDKETLEK 208
           ILVD K EFG   + GE++L DE  +PD SR W   T E+
Sbjct: 444 ILVDTKYEFGKDEHTGEILLIDEVHTPDSSRYWLASTYEE 483


>UniRef50_D0LZ80 Phosphoribosylaminoimidazolesuccinocarboxamidesy nthase n=1
           Tax=Haliangium ochraceum DSM 14365 RepID=D0LZ80_HALO1
          Length = 331

 Score = 48.9 bits (115), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 50/201 (24%), Positives = 81/201 (40%), Gaps = 33/201 (16%)

Query: 39  RIEQFDR-------KGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVEC 91
           R+  FDR       KG V N+   +   + A+   P  + R+      +V+++  +  E 
Sbjct: 51  RLSAFDRVLGTIPYKGQVLNQLAAYWFEETADIA-PNHVVRVPDPNVMVVREVTPLRAEF 109

Query: 92  VVRNRAAGSLVKRL--------------GIEEGIELNPPLFDLFLKNDAM-----HDPMV 132
           VVR+   G     +               + EG+  N PL +  L          HD  V
Sbjct: 110 VVRSYLTGVTSTSIWRAYESGARTFCGHALPEGMHKNQPLPEPILTPSTKAPQGEHDISV 169

Query: 133 NESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKG-----EV 187
           +       G +++E+  R  E+  K     ++   + GLIL D K E G+ K      E+
Sbjct: 170 SREELLASGVITEEHFDRAGEIAMKLFAFGQQRAAERGLILADTKYEMGVAKNAAGEDEI 229

Query: 188 VLGDEF-SPDGSRLWDKETLE 207
           ++ DE  +PD SR W  E  E
Sbjct: 230 LVIDEIHTPDSSRYWHAEDFE 250


>UniRef50_B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=11
           Tax=Bacteroidales RepID=PUR7_AZOPC
          Length = 323

 Score = 48.1 bits (113), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 64/235 (27%), Positives = 98/235 (41%), Gaps = 29/235 (12%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           Q  LY GK + VY T   D+LV+   +  SA D         KG V N+    I +K  +
Sbjct: 14  QTHLYHGKVRDVY-TVGSDMLVIIATDRISAFDVVLSRGIPYKGQVLNQ----IAAKFLD 68

Query: 64  AGIPTQMERLLSDTECLVKK---LDMVPVECVVRNRAAGSLVKRL--------------G 106
           +         L++ + +V      +   VE V+R    GS  ++               G
Sbjct: 69  STSDILPNWKLAEPDPMVTIGLLCEPFKVEMVIRGYLTGSAWRKYKEGERTLCAVTLPEG 128

Query: 107 IEEGIELNPPLFDLFLKNDAMHDPMVN-ESYCETFGWVSKENLARMKELTYKANDVLKKL 165
           ++E  +   P+     K    HD  ++ E   E F  VSKE+  +++  T        ++
Sbjct: 129 MKENEKFPNPIITPTTKAYKGHDENISKEEIIERF-LVSKEDYEQLEYYTRALFQRGTEI 187

Query: 166 FDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDRFRQSLG 219
               GLILVD K EFG   G + L DE  +PD SR +  E  +    +RF +  G
Sbjct: 188 ASSKGLILVDTKYEFGKKDGRIYLIDEIHTPDSSRYFYSEDYQ----ERFEKGEG 238


>UniRef50_Q6NRP1 LOC431975 protein (Fragment) n=2 Tax=Xenopus RepID=Q6NRP1_XENLA
          Length = 371

 Score = 48.1 bits (113), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 44/195 (22%), Positives = 85/195 (43%), Gaps = 13/195 (6%)

Query: 6   ELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
           +L   +A  VY  +E P  ++++ ++  +A   A     D K  V+NK    +   L EA
Sbjct: 87  KLREDEATEVYELSEQPGCVLIQSKDHINAQYTAWDGHKDTKASVSNKATSRVFILLQEA 146

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GI T   +  S+   +  + +M+P+E   R    G   +    +EG   + P  +++  +
Sbjct: 147 GIKTAFVKRCSEAAFIATQCEMIPIEWFCRKIPTG---RNTETDEGYRFSQPKVEMYKVD 203

Query: 125 DAMHDPMVNES------YCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL 178
           D  +  +  E        C     + K  +  M   T    ++++K +      LVD ++
Sbjct: 204 DTSNHQLSKEQLMAVKLICAGL-LIGKMEVDVMTRSTIAIFEIIEKAWRAQDCTLVDMRI 262

Query: 179 EFG--LYKGEVVLGD 191
           +FG  + K E++L D
Sbjct: 263 KFGVDVTKKEILLTD 277


>UniRef50_Q73PW0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Treponema denticola RepID=Q73PW0_TREDE
          Length = 316

 Score = 45.8 bits (107), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 61/232 (26%), Positives = 97/232 (41%), Gaps = 40/232 (17%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDR-------KGMVNNKFNYFIMSKLA 62
           GK +  YS E    L++            RI  FDR       KG V N+ + +      
Sbjct: 21  GKVRDWYSPEEGKRLIV---------TTDRISAFDRVLTALPYKGQVLNQLSLWWFENTK 71

Query: 63  EAGIPTQMERLLSDTECL-VKKLDMVPVECVVRNRAAGSLVKRLGIEEGI-ELNPPLFDL 120
           +  I         D  C+ V ++  +P+E +VR    G     L     + E N   +D 
Sbjct: 72  D--IIKNHIISCPDPNCIIVTEVKPLPIEVIVRGYITGVTSTALWYRYSLGERNIYGYDF 129

Query: 121 ---FLKNDAMHDPMVNESY------------CE---TFGWVSKENLARMKELTYKANDVL 162
                KN A+  P++  +             C+   + G++SKE    +++      +  
Sbjct: 130 PEGLKKNQALPKPIITPTTKGGPTGHDERLTCDEVVSQGYLSKEQWDFVQKAALALFERG 189

Query: 163 KKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDKETLEKMDKD 212
           +K   +AGLILVD K EFG+ K   ++L DE  +PD SR W  +T E+  K+
Sbjct: 190 QKSAKEAGLILVDTKYEFGVDKNNNILLIDEVHTPDSSRYWKLDTYEQRLKE 241


>UniRef50_Q978V1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Thermoplasmatales RepID=PUR7_THEVO
          Length = 294

 Score = 45.4 bits (106), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 55/226 (24%), Positives = 93/226 (41%), Gaps = 31/226 (13%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L  GK K VY  ++ D LV +F N  S  D     + D KG    + + F    +   G+
Sbjct: 4   LTTGKVKDVY--DDGDTLVFKFSNRISVFDKIIPNEIDNKGESLCRTSAFWFQLIESYGM 61

Query: 67  PTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKR---------- 104
            +    L+ +    V+K              ++P+E + R   AGSL  R          
Sbjct: 62  KSHFIELIDNRTMRVRKFAVPNKVSLGSSNYVIPLEFITRYYVAGSLYDRIKEGKVKPMD 121

Query: 105 LGI----EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
           +G+    E G +L  P+F+   K +   D ++ +      G ++ E+   + E  +K + 
Sbjct: 122 IGLKHVPEYGEKLIDPIFEATTKREET-DRLLTKKEAMEIGGLTLEDYCEIMEAVFKIDR 180

Query: 161 VLKKLFDDAGLILVDFKLEFGL-YKGEVVLGDEF-SPDGSRLWDKE 204
            +       GLI  D K E  L  +  +V+ D F + D  R WD++
Sbjct: 181 RIDMEVSKRGLIHADGKKEIALDRERRIVVVDTFGTADEDRFWDEK 226


>UniRef50_B3G3Y1 Saicars n=1 Tax=Adineta vaga RepID=B3G3Y1_ADIVA
          Length = 531

 Score = 45.1 bits (105), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 38/147 (25%), Positives = 59/147 (40%), Gaps = 27/147 (18%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARI------------------EQFDR 45
             +L+ GK KT+YS  +   L+   R D     G+ +                  +Q +R
Sbjct: 11  HQKLFDGKTKTIYSIIDQPSLICIHRKDHHDSSGSILSIPGSRRSSVDSTIRLNNQQHNR 70

Query: 46  -------KGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTECLV-KKLDMVPVECVVRNRA 97
                  KGM+           L EA IPT      +  +  + KK  M+P+  ++R  A
Sbjct: 71  NHTDILSKGMLTTSITTCAYEILREASIPTFYVAPYNQPDMFIAKKCTMIPILWIIRRLA 130

Query: 98  AGSLVKR-LGIEEGIELNPPLFDLFLK 123
             + VKR  GI  G    PP+ ++F K
Sbjct: 131 NETCVKRNPGIINGHRFIPPMIEIFYK 157


>UniRef50_B8IQA8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Proteobacteria RepID=B8IQA8_METNO
          Length = 323

 Score = 43.9 bits (102), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 41/144 (28%), Positives = 60/144 (41%), Gaps = 21/144 (14%)

Query: 79  CLVKKLDMVPVECVVRNRAAGSLVK------RLGIEE--------GIELNPPLFDLFLK- 123
            + ++LD++PVE VVR   AG+         R G+ E        G+  N  L +  L  
Sbjct: 94  VVARRLDILPVEIVVRGYLAGTTATSILTQYRAGLREMYGHRLPDGMRPNERLPEAILTP 153

Query: 124 ----NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
                +  HD  +        G +++E    +           ++L    GLIL D K E
Sbjct: 154 TTKAGEGGHDTPLTPDAILAQGLLTQEQWETVSRAALALFARGQELAARRGLILADTKYE 213

Query: 180 FGL-YKGEVVLGDEF-SPDGSRLW 201
           FG    G +VL DE  +PD SR W
Sbjct: 214 FGTDADGRIVLADEIHTPDSSRYW 237


>UniRef50_Q8UCE7 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2
           n=32 Tax=Alphaproteobacteria RepID=PUR72_AGRT5
          Length = 316

 Score = 43.1 bits (100), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 49/184 (26%), Positives = 80/184 (43%), Gaps = 35/184 (19%)

Query: 82  KKLDMVPVECVVRNRAAGS------LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNES 135
           K+LD++PVE VVR   AG+       + + G  +   ++ P  D    N  + +P++  +
Sbjct: 87  KRLDILPVEVVVRGYLAGTTGTSILTLYKKGERQMYGMSLP--DGMKDNQILPEPVITPT 144

Query: 136 YCETFGW----VSKENLARMKELTYKANDVLKK----LFDDA-------GLILVDFKLEF 180
                G     ++   +   K LT +  D L +    LF          GLILVD K EF
Sbjct: 145 SKAFDGGHDEPLTPSEIVEKKLLTQEQWDTLSRYALALFRHGQEIAAKQGLILVDTKYEF 204

Query: 181 GL-YKGEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQSLGGLIEAYEAV 228
           G    G ++L DE  +PD SR W  ++ ++           DKD  R  +G   + Y+  
Sbjct: 205 GTDENGTIILADEIHTPDSSRYWMADSYDESFREGKRPASFDKDFVRAWVGERCDPYKDA 264

Query: 229 ARRL 232
             ++
Sbjct: 265 VPKI 268


>UniRef50_Q94IQ2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Alveolata RepID=Q94IQ2_CRYCO
          Length = 522

 Score = 41.2 bits (95), Expect = 0.027,   Method: Compositional matrix adjust.
 Identities = 42/158 (26%), Positives = 70/158 (44%), Gaps = 18/158 (11%)

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR----------LGIEEGI---- 111
           +P  +   +  +  + KK+  + VE +VR    GS+             L + +G+    
Sbjct: 92  VPNALIENVDSSVVVQKKMTNLNVEFIVRGYLWGSMAAAYEKGDRTFCGLKVPDGLNRFQ 151

Query: 112 ELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGL 171
           + + PLF    K +  HD   N +Y E    + K+   + K++  K      +L    GL
Sbjct: 152 KFDEPLFTPTTKAEVGHDE--NMTYAEVEKLIGKDMAKKAKDVAMKLYARGAELMRKRGL 209

Query: 172 ILVDFKLEFGLYKGEV--VLGDEFSPDGSRLWDKETLE 207
           IL+D K EFGL +  V  V+ +  +PD SR+   E  E
Sbjct: 210 ILIDTKYEFGLDEHGVLHVIDEVNTPDSSRMCTVEEWE 247


>UniRef50_A4SAQ9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ostreococcus lucimarinus CCE9901 RepID=A4SAQ9_OSTLU
          Length = 367

 Score = 41.2 bits (95), Expect = 0.030,   Method: Compositional matrix adjust.
 Identities = 53/213 (24%), Positives = 86/213 (40%), Gaps = 23/213 (10%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK +  Y T +  + V   R   SA D   +     KG V N+ + +   K  E  +P
Sbjct: 72  YEGKVRDTYVTGDTMIAVTTDRQ--SAFD-RHLAYIPFKGAVLNQTSQWWF-KQTEHIVP 127

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEGIEL 113
             +         ++++ ++ P+E VVR    GS    L               +++G+  
Sbjct: 128 NAVVATPDPNVTVMRRCEVFPIEFVVRGYLTGSTSTSLWTHYKTGGRNYCGNALDDGMVK 187

Query: 114 N---PPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
           N   P         +  HD  ++       GW+ +++L      T +     +++    G
Sbjct: 188 NQKLPANIVTPTTKEKEHDRPISLEDIVKEGWMKQDDLDYCVAKTLEVFAYAQEVAATRG 247

Query: 171 LILVDFKLEFGL-YKGEVVLGDEF-SPDGSRLW 201
           LILVD K EFG    G + L DE  +PD SR W
Sbjct: 248 LILVDTKYEFGRDADGTIRLIDEINTPDSSRYW 280


>UniRef50_Q46F31 Putative uncharacterized protein n=1 Tax=Methanosarcina barkeri
          str. Fusaro RepID=Q46F31_METBF
          Length = 47

 Score = 40.4 bits (93), Expect = 0.046,   Method: Composition-based stats.
 Identities = 16/27 (59%), Positives = 22/27 (81%)

Query: 4  QAELYRGKAKTVYSTENPDLLVLEFRN 30
          + +LY GKAKT+Y T++PD L+ EFRN
Sbjct: 3  REQLYSGKAKTIYKTDDPDTLITEFRN 29


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_A7ZPS1 Phosphoribosylaminoimidazole-succinocarboxamide ...   334   2e-90
UniRef50_C8PXT0 Phosphoribosylaminoimidazole-succinocarboxamide ...   320   3e-86
UniRef50_Q2NCK7 Phosphoribosylaminoimidazole-succinocarboxamide ...   309   4e-83
UniRef50_A9VRE8 Phosphoribosylaminoimidazole-succinocarboxamide ...   309   5e-83
UniRef50_C9M8K7 Phosphoribosylaminoimidazole-succinocarboxamide ...   301   1e-80
UniRef50_B1YJ02 Phosphoribosylaminoimidazole-succinocarboxamide ...   301   2e-80
UniRef50_A6Q3C7 Phosphoribosylaminoimidazole-succinocarboxamide ...   295   6e-79
UniRef50_P73471 Phosphoribosylaminoimidazole-succinocarboxamide ...   295   1e-78
UniRef50_Q8TX83 Phosphoribosylaminoimidazole-succinocarboxamide ...   292   6e-78
UniRef50_Q38XX0 Phosphoribosylaminoimidazole-succinocarboxamide ...   290   3e-77
UniRef50_B8DTV0 Phosphoribosylaminoimidazole-succinocarboxamide ...   289   6e-77
UniRef50_A0AJM6 Phosphoribosylaminoimidazole-succinocarboxamide ...   286   4e-76
UniRef50_Q2GHH2 Phosphoribosylaminoimidazole-succinocarboxamide ...   284   1e-75
UniRef50_A7X0V7 Phosphoribosylaminoimidazole-succinocarboxamide ...   283   3e-75
UniRef50_C2D8C6 Phosphoribosylaminoimidazolesuccinocarboxamide s...   282   6e-75
UniRef50_Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide ...   282   6e-75
UniRef50_O57978 Phosphoribosylaminoimidazole-succinocarboxamide ...   281   2e-74
UniRef50_Q03E76 Phosphoribosylaminoimidazole-succinocarboxamide ...   279   5e-74
UniRef50_Q049L4 Phosphoribosylaminoimidazole-succinocarboxamide ...   278   1e-73
UniRef50_A4SE69 Phosphoribosylaminoimidazole-succinocarboxamide ...   277   2e-73
UniRef50_Q1AXB9 Phosphoribosylaminoimidazole-succinocarboxamide ...   277   2e-73
UniRef50_C6I122 Phosphoribosylaminoimidazole-succinocarboxamide ...   276   5e-73
UniRef50_B9EAY5 Phosphoribosylaminoimidazole-succinocarboxamide ...   275   1e-72
UniRef50_D2EKX6 Phosphoribosylaminoimidazole-succinocarboxamide ...   273   4e-72
UniRef50_Q3AHS3 Phosphoribosylaminoimidazole-succinocarboxamide ...   273   4e-72
UniRef50_B5IMM2 Phosphoribosylaminoimidazole-succinocarboxamide ...   273   4e-72
UniRef50_D0JBF3 Phosphoribosylaminoimidazole-succinocarboxamide ...   268   7e-71
UniRef50_A4FYT6 Phosphoribosylaminoimidazole-succinocarboxamide ...   268   1e-70
UniRef50_Q7V0C7 Phosphoribosylaminoimidazole-succinocarboxamide ...   267   2e-70
UniRef50_A9BIH1 Phosphoribosylaminoimidazole-succinocarboxamide ...   267   2e-70
UniRef50_O26272 Phosphoribosylaminoimidazole-succinocarboxamide ...   267   4e-70
UniRef50_Q03Y92 Phosphoribosylaminoimidazole-succinocarboxamide ...   254   1e-66
UniRef50_B8D414 Phosphoribosylaminoimidazolesuccinocarboxamide s...   253   5e-66
UniRef50_Q8D2M4 Phosphoribosylaminoimidazole-succinocarboxamide ...   253   5e-66
UniRef50_C2U7A6 Phosphoribosylaminoimidazole-succinocarboxamide ...   251   1e-65
UniRef50_C6XGE3 Phosphoribosylaminoimidazole-succinocarboxamide ...   246   4e-64
UniRef50_A8MCJ8 Phosphoribosylaminoimidazole-succinocarboxamide ...   245   1e-63
UniRef50_P22234 Phosphoribosylaminoimidazole carboxylase n=88 Ta...   244   2e-63
UniRef50_B8GCM2 Phosphoribosylaminoimidazole-succinocarboxamide ...   240   2e-62
UniRef50_Q4J8G0 Phosphoribosylaminoimidazole-succinocarboxamide ...   236   4e-61
UniRef50_B1LCA5 Phosphoribosylaminoimidazole-succinocarboxamide ...   233   4e-60
UniRef50_UPI00006A4774 PREDICTED: similar to phosphoribosylamino...   231   1e-59
UniRef50_A3MXE4 Phosphoribosylaminoimidazole-succinocarboxamide ...   226   5e-58
UniRef50_Q648Z8 Phosphoribosylaminoimidazolesuccinocarboxamide s...   226   7e-58
UniRef50_A8ZVI6 Phosphoribosylaminoimidazole-succinocarboxamide ...   224   2e-57
UniRef50_A9VBB9 Phosphoribosylaminoimidazole-succinocarboxamide ...   224   2e-57
UniRef50_A8AAS3 Phosphoribosylaminoimidazole-succinocarboxamide ...   222   7e-57
UniRef50_B4Q3U0 GD23841 n=2 Tax=melanogaster subgroup RepID=B4Q3...   222   8e-57
UniRef50_C1A3U9 Phosphoribosylaminoimidazole-succinocarboxamide ...   222   8e-57
UniRef50_Q47KH4 Phosphoribosylaminoimidazole-succinocarboxamide ...   221   1e-56
UniRef50_A5CCM2 Phosphoribosylaminoimidazole-succinocarboxamides...   221   1e-56
UniRef50_D0MIB5 Phosphoribosylaminoimidazolesuccinocarboxamidesy...   220   2e-56
UniRef50_A8GML2 Phosphoribosylaminoimidazole-succinocarboxamide ...   220   4e-56
UniRef50_A6LDF8 Phosphoribosylamidoimidazole-succinocarboxamide ...   219   6e-56
UniRef50_C4FB69 Phosphoribosylaminoimidazole-succinocarboxamide ...   218   9e-56
UniRef50_Q9VK80 CG17024 n=4 Tax=melanogaster group RepID=Q9VK80_...   218   1e-55
UniRef50_A7H9G3 Phosphoribosylaminoimidazolesuccinocarboxamide s...   218   1e-55
UniRef50_B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide ...   218   2e-55
UniRef50_B2KCE9 Phosphoribosylaminoimidazole-succinocarboxamide ...   216   4e-55
UniRef50_Q72UH8 Phosphoribosylaminoimidazole-succinocarboxamide ...   216   7e-55
UniRef50_A1VU36 Phosphoribosylaminoimidazole-succinocarboxamide ...   216   7e-55
UniRef50_B5GT63 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   7e-55
UniRef50_A6GYJ4 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   8e-55
UniRef50_C6BVA6 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   1e-54
UniRef50_Q313T8 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   1e-54
UniRef50_Q5X4M9 Phosphoribosylaminoimidazole-succinocarboxamide ...   214   2e-54
UniRef50_C6CV28 Phosphoribosylaminoimidazolesuccinocarboxamide s...   213   6e-54
UniRef50_B5JQ22 Phosphoribosylaminoimidazole-succinocarboxamide ...   211   2e-53
UniRef50_A8LCN0 Phosphoribosylaminoimidazole-succinocarboxamide ...   210   4e-53
UniRef50_Q67KF6 Phosphoribosylaminoimidazole-succinocarboxamide ...   208   9e-53
UniRef50_Q9UUB4 Phosphoribosylaminoimidazole-succinocarboxamide ...   208   1e-52
UniRef50_C9KPE2 Phosphoribosylaminoimidazole-succinocarboxamide ...   208   1e-52
UniRef50_Q11TT6 Phosphoribosylaminoimidazole-succinocarboxamide ...   208   2e-52
UniRef50_B0VH32 Phosphoribosylaminoimidazole-succinocarboxamide ...   206   5e-52
UniRef50_A9A5G9 Phosphoribosylaminoimidazole-succinocarboxamide ...   205   1e-51
UniRef50_Q7UJ19 Phosphoribosylaminoimidazole-succinocarboxamide ...   204   3e-51
UniRef50_Q3Z881 Phosphoribosylaminoimidazole-succinocarboxamide ...   202   8e-51
UniRef50_Q73PW0 Phosphoribosylaminoimidazole-succinocarboxamide ...   200   2e-50
UniRef50_A7BA15 Phosphoribosylaminoimidazole-succinocarboxamide ...   200   3e-50
UniRef50_D0LZ80 Phosphoribosylaminoimidazolesuccinocarboxamidesy...   198   9e-50
UniRef50_UPI000187DCD8 hypothetical protein MPER_11578 n=1 Tax=M...   198   2e-49
UniRef50_P27616 Phosphoribosylaminoimidazole-succinocarboxamide ...   197   3e-49
UniRef50_B7FS23 Phosphoribosylaminoimidazole-succinocarboxamide ...   193   3e-48
UniRef50_B3DVV2 Phosphoribosylaminoimidazolesuccinocarboxamide (...   193   6e-48
UniRef50_Q5P7J7 Phosphoribosylaminoimidazole-succinocarboxamide ...   190   4e-47
UniRef50_C7NLA9 Phosphoribosylaminoimidazole-succinocarboxamide ...   189   5e-47
UniRef50_B3V647 Phosphoribosylaminoimidazole-succinocarboxamide ...   189   5e-47
UniRef50_Q9P9D8 SAICAR synthase n=1 Tax=uncultured marine group ...   186   4e-46
UniRef50_C5A6A8 Phosphoribosylaminoimidazole-succinocarboxamide ...   183   4e-45
UniRef50_B3T553 Putative SAICAR synthetase n=2 Tax=prokaryotic e...   180   3e-44
UniRef50_Q9HLC0 Phosphoribosylaminoimidazole-succinocarboxamide ...   175   9e-43
UniRef50_B2A872 Phosphoribosylaminoimidazole-succinocarboxamide ...   175   1e-42
UniRef50_C7M1W2 Phosphoribosylaminoimidazolesuccinocarboxamide s...   174   3e-42
UniRef50_Q83GX1 Phosphoribosylaminoimidazole-succinocarboxamide ...   172   8e-42
UniRef50_B8J393 Phosphoribosylaminoimidazolesuccinocarboxamide s...   172   1e-41
UniRef50_UPI000038E095 phosphoribosylaminoimidazole-succinocarbo...   169   6e-41
UniRef50_C7RD67 Phosphoribosylaminoimidazole-succinocarboxamide ...   167   2e-40
UniRef50_Q978V1 Phosphoribosylaminoimidazole-succinocarboxamide ...   165   9e-40
UniRef50_UPI0001926A10 PREDICTED: similar to phosphoribosylamino...   165   1e-39
UniRef50_Q895U7 Phosphoribosylaminoimidazole-succinocarboxamide ...   164   2e-39
UniRef50_Q466M0 Phosphoribosylaminoimidazole-succinocarboxamide ...   156   6e-37
UniRef50_B5GV74 Saicar synthetase n=1 Tax=Streptomyces clavulige...   153   5e-36
UniRef50_Q6NRP1 LOC431975 protein (Fragment) n=2 Tax=Xenopus Rep...   148   1e-34
UniRef50_A8M140 SAICAR synthetase n=1 Tax=Salinispora arenicola ...   146   6e-34
UniRef50_B3G3Y1 Saicars n=1 Tax=Adineta vaga RepID=B3G3Y1_ADIVA       111   2e-23
UniRef50_UPI00015FF598 UPI00015FF598 related cluster n=1 Tax=Dro...   107   3e-22
UniRef50_Q3CXY3 Phosphoribosylaminoimidazole-succinocarboxamide ...    84   3e-15

Sequences not found previously or not previously below threshold:

UniRef50_Q8UCE7 Putative phosphoribosylaminoimidazole-succinocar...   206   7e-52
UniRef50_B8IQA8 Phosphoribosylaminoimidazole-succinocarboxamide ...   204   1e-51
UniRef50_C0A6D3 Phosphoribosylaminoimidazolesuccinocarboxamide s...   204   2e-51
UniRef50_P38025 Phosphoribosylaminoimidazole-succinocarboxamide ...   196   6e-49
UniRef50_A4SAQ9 Phosphoribosylaminoimidazole-succinocarboxamide ...   195   1e-48
UniRef50_B0U1N3 Phosphoribosylaminoimidazole-succinocarboxamide ...   188   1e-46
UniRef50_Q94IQ2 Phosphoribosylaminoimidazole-succinocarboxamide ...   169   8e-41
UniRef50_Q7MLF9 Phosphoribosylaminoimidazole-succinocarboxamide ...   133   4e-30
UniRef50_A4NXH0 Phosphoribosylaminoimidazole-succinocarboxamide ...   128   1e-28
UniRef50_Q6MIY7 Phosphoribosylaminoimidazolesuccinocarboxamide s...   116   9e-25
UniRef50_D2RHF2 Phosphoribosylaminoimidazole-succinocarboxamide ...   114   3e-24
UniRef50_B2L3N2 Phosphoribosylaminoimidazole carboxylase n=3 Tax...   110   4e-23
UniRef50_O28996 Putative phosphoribosylaminoimidazole-succinocar...   107   2e-22
UniRef50_A8M136 SAICAR synthetase n=1 Tax=Salinispora arenicola ...   106   5e-22
UniRef50_A8EWL2 Phosphoribosylaminoimidazole-succinocarboxamide ...   106   8e-22
UniRef50_Q5IWX2 Plastid phosphoribosylaminoimidazole-succinocarb...   105   1e-21
UniRef50_D1JGB5 Putative phosphoribosylaminoimidazole-succinocar...   105   1e-21
UniRef50_Q3IMR8 Phosphoribosylaminoimidazolesuccinocarboxamide s...   103   5e-21
UniRef50_D0NC79 Phosphoribosylaminoimidazole-succinocarboxamide ...    97   5e-19
UniRef50_B5YAR6 Phosphoribosylaminoimidazole-succinocarboxamide ...    94   4e-18
UniRef50_Q9HNU7 Putative phosphoribosylaminoimidazole-succinocar...    93   6e-18
UniRef50_Q2GR92 Putative uncharacterized protein n=1 Tax=Chaetom...    89   1e-16
UniRef50_B2L3L7 Phosphoribosylaminoimidazole carboxylase n=1 Tax...    88   2e-16
UniRef50_UPI0001746899 phosphoribosylaminoimidazolesuccinocarbox...    67   3e-10
UniRef50_B4N726 GK23628 n=2 Tax=Drosophila willistoni RepID=B4N7...    58   3e-07
UniRef50_Q9F8W0 SAICAR synthetase (Fragment) n=2 Tax=Rhizobium/A...    52   1e-05
UniRef50_Q0PQG5 Phosphoribosylaminoimidazole-succinocarboxamide ...    52   2e-05
UniRef50_Q67KF5 Putative uncharacterized protein n=1 Tax=Symbiob...    52   2e-05
UniRef50_Q46F31 Putative uncharacterized protein n=1 Tax=Methano...    40   0.073

>UniRef50_A7ZPS1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=182
           Tax=Gammaproteobacteria RepID=PUR7_ECO24
          Length = 237

 Score =  334 bits (856), Expect = 2e-90,   Method: Composition-based stats.
 Identities = 237/237 (100%), Positives = 237/237 (100%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK
Sbjct: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL
Sbjct: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF
Sbjct: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD 237
           GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
Sbjct: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD 237


>UniRef50_C8PXT0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Gammaproteobacteria RepID=C8PXT0_9GAMM
          Length = 242

 Score =  320 bits (820), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 152/236 (64%), Positives = 188/236 (79%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK   LY+GKAK+V+ T+NPD L+LEFR+DTSA +G RIEQ  RKG VNN+FN FIM K
Sbjct: 1   MQKLDLLYKGKAKSVFETDNPDYLILEFRDDTSAFNGERIEQLARKGKVNNRFNAFIMQK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L+EAGI T  E+ LSD E LVK+L M+PVECVVRN AAGSLV+RLG++EG  L PP F+L
Sbjct: 61  LSEAGIETHFEQQLSDEEVLVKRLTMIPVECVVRNYAAGSLVRRLGLQEGQALTPPTFEL 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DPMVN+S   + GW ++  L  MK LT+K NDVL K+FDD GL+LVDFKLEF
Sbjct: 121 FYKDDGLGDPMVNDSLAVSLGWATQAQLDEMKALTFKVNDVLSKMFDDGGLMLVDFKLEF 180

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQL 236
           G++K  +VLGDEFSPDG R+WDK+T +K+DKDRFRQSLG ++E YE VA+R+GV L
Sbjct: 181 GVFKDRIVLGDEFSPDGCRVWDKQTKKKLDKDRFRQSLGDVVEGYEEVAKRIGVSL 236


>UniRef50_Q2NCK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=346
           Tax=cellular organisms RepID=PUR7_ERYLH
          Length = 272

 Score =  309 bits (793), Expect = 4e-83,   Method: Composition-based stats.
 Identities = 98/238 (41%), Positives = 147/238 (61%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M ++ ++Y GKAK +Y    P  ++  F++D +A +  +      KG++NN+ +  + ++
Sbjct: 1   MSRRRQIYEGKAKILYEGPEPGTIIQYFKDDATAFNAEKKGTISGKGVINNRISEHVFTR 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L+  GIPT   R L+  E LV++ +++P+E VVRN AAGS+ KRLGI EG  L   L + 
Sbjct: 61  LSHIGIPTHFIRRLNMREQLVRQCEIIPIEVVVRNVAAGSISKRLGIPEGEPLPHTLIEY 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D++ DP++ E +   F W S E +  +  +  + ND +  +F    + LVDFKLEF
Sbjct: 121 YYKDDSLGDPLIAEEHIACFNWASPEEMQDIASMAIRINDFMAGMFAAIDIRLVDFKLEF 180

Query: 181 GLY-KG---EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G    G    V+L DE SPDG RLWD  + EK+DKDRFR+ LGG  EAY+ VARRLG+
Sbjct: 181 GRIYDGDFSRVILADEISPDGCRLWDMNSGEKLDKDRFRRDLGGESEAYQEVARRLGL 238


>UniRef50_A9VRE8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=155
           Tax=cellular organisms RepID=PUR7_BACWK
          Length = 239

 Score =  309 bits (792), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 101/234 (43%), Positives = 145/234 (61%), Gaps = 1/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK   LY GKAK +Y TE  D++ +E+++  +A +G +      KG +NN+    +  K
Sbjct: 1   MQKLELLYEGKAKRIYRTEAADMVWVEYKDSATAFNGEKKATITGKGRLNNEITTLLFRK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T     LSDTE LVKK+ ++P+E V RN  AGSL KRLG+EEG  L  P+ + 
Sbjct: 61  LQEVGIKTHFVEKLSDTEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTALTTPIVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D + DP+V E +       + E ++ +++   + N V+ + F    + LVDFKLEF
Sbjct: 121 YYKDDDLGDPLVTEDHIRLLNVATPEQVSVLRDAALQINQVMIEHFASCRVRLVDFKLEF 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G+  +GE++L DE SPD  RLWD+ + EK DKD FR+ LG L EAYE + +RLG
Sbjct: 181 GVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTEAYEEILKRLG 234


>UniRef50_C9M8K7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Jonquetella anthropi E3_33 E1 RepID=C9M8K7_9BACT
          Length = 251

 Score =  301 bits (772), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 91/232 (39%), Positives = 156/232 (67%), Gaps = 1/232 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK ++ST++P++L++++++  +A +  + ++   KG +NN  + +I + LA+ 
Sbjct: 16  ELLYEGKAKKIFSTDDPNVLLVQYKDSLTAFNAKKRDEKAGKGHLNNVISSWIFTWLAKK 75

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+ +   + + +T  L++K++++P+E +VRN   GSL +RLG+EEG +L+ P+ +   K+
Sbjct: 76  GVESHFIKQVDETHQLIRKVEIIPLETIVRNVTTGSLCRRLGVEEGKKLSRPIIEFSYKS 135

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           DA+ DP++N+ +    GW ++E +A +K +  K N +L +LF   G++LVDFKLEFG   
Sbjct: 136 DALDDPLINDDHAIVLGWATEEEVATIKSIALKVNKLLTELFASVGVLLVDFKLEFGRDE 195

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
           KG V+L DE SPD  R WD +T + +DKDRFR+ LG ++ AYE + RRL  +
Sbjct: 196 KGRVLLADEISPDTCRFWDSKTHDHLDKDRFRKDLGDVLGAYEEIWRRLSAR 247


>UniRef50_B1YJ02 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Bacteria RepID=PUR7_EXIS2
          Length = 235

 Score =  301 bits (771), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 97/230 (42%), Positives = 149/230 (64%), Gaps = 1/230 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK +Y+T++ D+L + ++++ +A +G +  +F  KG +NN+        LA A
Sbjct: 2   QPLYEGKAKRLYTTQDQDVLRIVYKDEATAFNGEKKAEFAGKGELNNRLTSHFFEVLAAA 61

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GIPT      S+ E LV+++ ++P+E VVRN  AGSL KRLGIEEG  L  P+ + + K+
Sbjct: 62  GIPTHFIEQTSEREQLVRRVTIIPLEVVVRNVVAGSLSKRLGIEEGTVLETPIVEFYYKD 121

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           D++ DP+V  ++       + E L+ +++   + NDVL+  FD+ G+ L+DFKLE+G   
Sbjct: 122 DSLGDPLVTPAHINLLKIATTEELSLLEQEANRVNDVLRPYFDEKGITLIDFKLEYGKTP 181

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
            GE++L DE SPD  RLWDKET E +DKD FR+++G LI+ Y+ +  RLG
Sbjct: 182 AGEILLADEISPDTCRLWDKETGEHLDKDVFRRNIGSLIDTYQTLFNRLG 231


>UniRef50_A6Q3C7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=17
           Tax=Epsilonproteobacteria RepID=PUR7_NITSB
          Length = 239

 Score =  295 bits (757), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 99/234 (42%), Positives = 142/234 (60%), Gaps = 2/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   LY GKAK ++ T++ ++L+ EF++  +A D  +  +   KG +N K +  +   
Sbjct: 1   MKKTELLYEGKAKKIWKTDDENILIAEFKDSLTAFDAQKKSEEAGKGALNCKISANLFKL 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T     +S+ E ++KK +M+ +E VVRN A GSL KRLGI +G +L   L + 
Sbjct: 61  LEEQGIKTHFVECISENEMVIKKAEMIMIEVVVRNIATGSLTKRLGIPDGTKLPFALVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKE-NLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
           + KNDA+HDP++N+ +      V  E  L  +K L  + N VLK  FD A L LVDFK+E
Sbjct: 121 YYKNDALHDPLINDEHALILELVDHESELEELKRLGREINVVLKSFFDKANLNLVDFKVE 180

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           FG   +G ++L DE SPD  R WDK + EK+DKD FR  LG +  AYE V +R+
Sbjct: 181 FGKDSEGNIILADEISPDSCRFWDKTSGEKLDKDLFRHDLGNVKVAYEEVLKRI 234


>UniRef50_P73471 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=69
           Tax=Bacteria RepID=PUR7_SYNY3
          Length = 264

 Score =  295 bits (755), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 90/238 (37%), Positives = 139/238 (58%), Gaps = 5/238 (2%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            +LY GKAK +Y TE+PD+L+  F++D +A +  +  Q   KG +N   +  +   L   
Sbjct: 18  EKLYEGKAKILYPTEDPDVLLTIFKDDATAFNAQKKGQIQGKGAINCAISAALFRWLETL 77

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GIPT       + + LVK ++++P+E VVRN AAGSL K+ G++EG+ L  PL + + K+
Sbjct: 78  GIPTHYIDCPQNDQMLVKAVNIIPLEVVVRNIAAGSLCKQTGLKEGLVLPNPLVEFYFKD 137

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           DA+ DP++        G   +  L  +K+L    N  L++ F    + LVDFKLEFG   
Sbjct: 138 DALGDPLLTWERALLLGVTDEARLQTLKDLALNINQHLQRFFAQCDITLVDFKLEFGGDR 197

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEK----MDKDRFRQSLGGLIEAYEAVARRLGVQLD 237
           +G+++L DE SPD  RLWD    +     +DKDRFR+ LG +  AY+ V +R+  Q++
Sbjct: 198 QGKIILADEISPDTCRLWDNAQADPQARVLDKDRFRRDLGSIEAAYQTVEKRVLSQIE 255


>UniRef50_Q8TX83 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=cellular organisms RepID=PUR7_METKA
          Length = 247

 Score =  292 bits (748), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 99/234 (42%), Positives = 146/234 (62%), Gaps = 2/234 (0%)

Query: 1   MQKQAELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M++   +Y GKAK++Y   E+ +LLV+EFR+D +A +  +++  + KG+ N   +  +  
Sbjct: 1   MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFE 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L +AGIPT    L  +   +V++LDM  +E + RN A GSLV+RL  EEG +L+PP+ +
Sbjct: 61  VLEDAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVE 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K+D   DPMVN  +    G  ++E + RM+ELT + N+VL +   D  +ILVDFKLE
Sbjct: 121 FDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVNEVLSEFLKDCDIILVDFKLE 180

Query: 180 FGL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           FG+   GEVV+GDE SPD  R WD ET E +DKD FR+  G ++  Y   A R+
Sbjct: 181 FGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERI 234


>UniRef50_Q38XX0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=27
           Tax=Lactobacillales RepID=PUR7_LACSS
          Length = 241

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 95/228 (41%), Positives = 148/228 (64%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK ++ST++P++L + +++  +A +G R EQ   KG VN + +  I + L++ 
Sbjct: 4   TLLYSGKAKDLFSTDDPEVLKMIYKDQATALNGKRKEQITGKGEVNYEISKLIFAYLSQQ 63

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GI T + + +S+TE LVKK+ ++P+E V+RN  AGS  ++ G   G  L  P+ + + KN
Sbjct: 64  GIETHLIKNVSETEQLVKKVTIIPLEVVLRNVVAGSFARKFGQPLGQRLEQPIIEYYYKN 123

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           DA+ DP +N S       V+   +A ++ +T + N +L KLF++ G+ L+DFKLEFG Y+
Sbjct: 124 DALDDPAINISQATALKLVTPTEVATIEAMTKQINTLLIKLFNEIGIDLIDFKLEFGRYQ 183

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G ++L DEFSPD  RLWD++T   +DKD FRQ+ G L+  YE V +RL
Sbjct: 184 GRLILADEFSPDNCRLWDQKTHSSLDKDVFRQNKGDLVTVYETVLQRL 231


>UniRef50_B8DTV0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=16
           Tax=Bacteria RepID=PUR7_BIFA0
          Length = 250

 Score =  289 bits (740), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 99/237 (41%), Positives = 143/237 (60%), Gaps = 5/237 (2%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK  +LY GKAK +Y+T++PD+L +E+ N  +AG+GA+  Q + KG +NN+    I   
Sbjct: 1   MQKLDKLYEGKAKKLYATDDPDVLWVEYMNQATAGNGAKKAQIEGKGELNNQITSVIFDL 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI +   + +SDTE LV+K+DM P+E ++RN AAGS  KR G+EEG  L+ P+ + 
Sbjct: 61  LKARGIDSHFVKRISDTEQLVRKMDMYPLEIIMRNTAAGSFAKRYGVEEGTALDKPILEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
            +K+D + DP +N+      G  S+E L  +       ND LK +F    + LVDFK+E 
Sbjct: 121 CVKSDELGDPFINDDGIVALGIASEEELDEISRQARAVNDALKDIFSKIDVQLVDFKIEE 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETL----EKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    G ++L DE +PD  RLWD +      E +DKD FR+ LG +I AYE +  RL
Sbjct: 181 GKTGDGRILLADEITPDTCRLWDLKDGSGQIEHLDKDLFRRDLGNIIPAYEEIYDRL 237


>UniRef50_A0AJM6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=66
           Tax=Bacteria RepID=PUR7_LISW6
          Length = 237

 Score =  286 bits (732), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 95/230 (41%), Positives = 141/230 (61%), Gaps = 1/230 (0%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
              +Y GKAK ++ TE   +L + +++D +A +G R E F  KG +NN+    I S L E
Sbjct: 3   NELVYEGKAKQLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITALIFSYLEE 62

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
           AGI +   R +S+TE LVK++ ++P+E VVRN  AGSL KRLG EEG E+   + + + K
Sbjct: 63  AGIRSHFIRAISETEQLVKEVSIIPLEVVVRNVIAGSLAKRLGKEEGEEIPSAIVEFYYK 122

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
            DA+ DP +N+ +       +   +  +++     N+VL+ LF+   + L+DFKLEFG  
Sbjct: 123 EDALDDPFINDDHVLYLEIATTNEMEVIRKAARSINEVLQVLFNQMNITLIDFKLEFGRD 182

Query: 184 -KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             G ++L DE SPD  RLWDKET +K+DKD FR+++G L + Y  V  RL
Sbjct: 183 ADGNILLADEISPDTCRLWDKETKQKLDKDVFRRNIGNLTDVYTEVLNRL 232


>UniRef50_Q2GHH2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=Rickettsiales RepID=PUR7_EHRCR
          Length = 242

 Score =  284 bits (728), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 94/238 (39%), Positives = 150/238 (63%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+ + ++Y GKAK +++T NP  ++  F+++ +A +  +      KG++NN  + F+M K
Sbjct: 1   MENKEKIYEGKAKIIFATLNPLEVIQHFKDEITAFNNKKAAIIHEKGILNNYISSFLMKK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L + GI T    LL+  E LVKK+ ++P+E V+RN AAG+  KR  I +G     P+ + 
Sbjct: 61  LIDKGIKTHFISLLNQREQLVKKITIIPIEVVIRNLAAGNFSKRFQIADGTPFKSPIIEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + KND + DPMV+E +  +F W++ + L ++K L+ K N++L +LF + G+ LVDFKLEF
Sbjct: 121 YYKNDELSDPMVSEGHILSFQWLTNQELEKIKILSLKINNILSELFFNVGIKLVDFKLEF 180

Query: 181 GL----YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G      + ++ L DE SPD  RLWD  T +++DKDR+R +LG +IE Y  VA +L  
Sbjct: 181 GKLHNDEQSDLFLADEISPDTCRLWDISTNKRLDKDRYRLNLGNVIEGYREVAHKLNA 238


>UniRef50_A7X0V7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=58
           Tax=Bacilli RepID=PUR7_STAA1
          Length = 234

 Score =  283 bits (725), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 95/229 (41%), Positives = 141/229 (61%), Gaps = 1/229 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK ++ST   + L +E++++ +AG+GA+ +    KG +NN+    I   L E 
Sbjct: 2   TLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQEN 61

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GI +   + LS+TE LVK + ++P+E VVRN A+GS+ KRLG E G     PL + F KN
Sbjct: 62  GIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKN 121

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           DA++DP++ + + +     S E++  +K    K N+VLK+L D   L LVDFK+EFG  +
Sbjct: 122 DALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTE 181

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G+++L DE SPD  R+WDK T    DKD +R + G LIE Y+    +L
Sbjct: 182 TGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKL 230


>UniRef50_C2D8C6 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Atopobium vaginae DSM 15829 RepID=C2D8C6_9ACTN
          Length = 238

 Score =  282 bits (723), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 112/233 (48%), Positives = 150/233 (64%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK    Y GKAK +Y T++P LL + +++  +AGDGA+ EQ   KG +N K    I + 
Sbjct: 1   MQKGKLSYVGKAKDMYETDDPRLLWMVYKDQATAGDGAKKEQIAGKGELNQKITRLIFAY 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           LA+ GI T +++++SDTE LV+KLDM  +E V+RN AAGS+V+RLGIE+G E    + + 
Sbjct: 61  LADHGIKTHLKKIISDTEELVEKLDMFELEVVLRNLAAGSIVRRLGIEKGTEFKGGMIEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D +HDP++ +         +   L  +K LT + N +L +LF  AGLILVDFKLEF
Sbjct: 121 YYKSDDLHDPLLTDDNLMFMHLATPAQLQEIKRLTLEVNTLLTELFKRAGLILVDFKLEF 180

Query: 181 GL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    GEVVLGDEFSPD  RLWD  T E  DKD FR S   +I  Y+AV  RL
Sbjct: 181 GTNADGEVVLGDEFSPDNCRLWDVHTHESFDKDIFRNSDEDMIPFYKAVYERL 233


>UniRef50_Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Methanomicrobia RepID=PUR7_METBU
          Length = 238

 Score =  282 bits (722), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 99/230 (43%), Positives = 134/230 (58%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K  ELY GKAKT+Y TENP+ L+ EFR+  +A DG +  +   KG  N + +  I   L 
Sbjct: 2   KTEELYSGKAKTIYKTENPNELISEFRDSLTAFDGKKKSEATNKGYYNAQISKKIFEMLE 61

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
           E GI T    ++S  E LVKK+D++ +E + RN AAGS+ ++  +EEG     P+     
Sbjct: 62  EEGIKTHYLGMVSGNEMLVKKVDIILIEVIPRNIAAGSITRKYPVEEGTVFKEPVLVFDY 121

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           K+D   DPM+N+      G  ++E +  ++ +  K N +LK   +  G +L DFKLEFG 
Sbjct: 122 KSDEFGDPMINDDIAVVMGIATREEIDFIRSMALKINAILKSYLESNGFLLPDFKLEFGR 181

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             GE+VL DE S D  R WD ET E MDKD FR   G L +AYE VARRL
Sbjct: 182 VDGEIVLADEISCDTCRFWDVETGESMDKDLFRFDKGDLSKAYEKVARRL 231


>UniRef50_O57978 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=7
           Tax=cellular organisms RepID=PUR7_PYRHO
          Length = 238

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 100/233 (42%), Positives = 142/233 (60%), Gaps = 3/233 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M K  E+Y GKAK +   ++ D L++EF++D +A DG +  +F  KG +N + +      
Sbjct: 1   MVKLMEVYEGKAKKMIPIDD-DKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKL 59

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T    +      +V+KLDM P+E VVRN  AGSL KRL + EG EL  P+ +L
Sbjct: 60  LEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVEL 119

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + KND +HDPM+N  + +  G  S + + +++E+  K N++LK      G+ILVDFKLEF
Sbjct: 120 YYKNDELHDPMINYYHAKVLGI-SLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEF 178

Query: 181 GLYK-GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G  K G++VL DE SPD  R WD +T   +DKD FR   G LIEAY+ +  R+
Sbjct: 179 GKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERI 231


>UniRef50_Q03E76 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=15
           Tax=Bacilli RepID=PUR7_PEDPA
          Length = 242

 Score =  279 bits (715), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 83/234 (35%), Positives = 132/234 (56%), Gaps = 1/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   +  GKAK +Y+T+  DL+ +E+ +  +A +G R +    KG +NN+ +  +  +
Sbjct: 1   MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQ 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI T   + LS+ E L +K+ ++P+E VVRN A+GS  ++  +      + P+ + 
Sbjct: 61  LVAKGIHTDFVQKLSNNEQLNRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DP +N +       +  E   R++++  + N +LK+ F  A L LVDFK+EF
Sbjct: 121 FYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQILKERFAKAHLQLVDFKVEF 180

Query: 181 GL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G     E+VL DE SPD  RL D  T E +DKD FR+  G L+  Y+ V  RL 
Sbjct: 181 GKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLN 234


>UniRef50_Q049L4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Lactobacillus delbrueckii subsp. bulgaricus
           RepID=Q049L4_LACDB
          Length = 240

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 103/230 (44%), Positives = 154/230 (66%), Gaps = 2/230 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY+GK K +++T++P++L   +++D +A DG + + F  KG ++ + +  +   L + 
Sbjct: 3   ELLYQGKTKEMWTTDDPEVLRAVYKDDATALDGLKHDVFQNKGELDAEISSLVFEYLMKH 62

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFDLFLK 123
           G+ T   + LS  E LVKK+ M+ +E V RN AAGS  KR G+ EEG +L+ P+ +LF+K
Sbjct: 63  GVKTHFIKRLSKNEQLVKKVKMIDLEVVTRNIAAGSFCKRYGLKEEGEKLDTPVEELFMK 122

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG-L 182
           +DA+HDP++NES    F  ++ E   ++ E++ + N +L KLF DAG++LVDFK+EFG L
Sbjct: 123 SDALHDPLMNESDAIAFHLLTHEEHEQIWEISRQVNQLLTKLFADAGMLLVDFKVEFGTL 182

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             GEVVL DEFSPD  RLWD ET + MDKD +R+ +G LI+ YE V  RL
Sbjct: 183 PNGEVVLADEFSPDNCRLWDMETKDHMDKDVYRRQIGNLIDVYERVLARL 232


>UniRef50_A4SE69 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=25
           Tax=Bacteria RepID=PUR7_PROVI
          Length = 238

 Score =  277 bits (709), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 105/232 (45%), Positives = 146/232 (62%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M K   L+ GKAK V+ T++ DL++ EF++D +A +  +      KG+VNN  +  + + 
Sbjct: 3   MNKTTLLHEGKAKKVFLTDDADLVIQEFKDDATAFNNKKKGSIADKGVVNNAISCRLFTM 62

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E G+ T +   LSD + L ++LD++ VE VVRN AAGSLV+R G  EG  L  P+ + 
Sbjct: 63  LEEHGVNTHLVEKLSDRDMLCRRLDIIKVEVVVRNIAAGSLVRRYGFTEGTVLARPIVEF 122

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           +LK+D + DP++   +    G  + + L  +K      NDVLKK F D  L LVDFKLEF
Sbjct: 123 YLKDDDLDDPLMIAEHAVALGVATMDELEVLKSRAGAINDVLKKFFADRRLKLVDFKLEF 182

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G +KGE++LGDE SPD  R WD +T EKMDKDRFR  LGG+ +AY  V RR+
Sbjct: 183 GRHKGEILLGDEISPDTCRFWDLDTDEKMDKDRFRFDLGGVEDAYTEVQRRV 234


>UniRef50_Q1AXB9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacteria RepID=Q1AXB9_RUBXD
          Length = 237

 Score =  277 bits (709), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 94/231 (40%), Positives = 138/231 (59%), Gaps = 2/231 (0%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  LY GKAK V+ T    +L+  ++++ +A +  +   +  KG  N   +  + + L 
Sbjct: 2   KRTLLYEGKAKQVFETGEEGVLLHRYKDEATAFNARKRGSWAGKGRANASISAAVFAYLE 61

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GIPT     + +     ++L M+PVE +VRN AAGSL + LG EEG  L  P+ +L  
Sbjct: 62  RRGIPTHFIEQVDEVTLKTRRLRMLPVEIIVRNLAAGSLARLLGYEEGRPLKAPVVELCY 121

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           KNDA+ DPM+N  +    G  + E L   +E   + N+ L+  F++ G++LVDFK+E G 
Sbjct: 122 KNDALGDPMLNWYHFRELGL-TDEELRACEEFGLRVNEALRPFFEERGMVLVDFKIEVGR 180

Query: 183 Y-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
              G +VL DE SPD  RLWDKET +++DKDRFR+ LGG+ EAYE V RR+
Sbjct: 181 DAGGSLVLADEISPDTCRLWDKETGQRLDKDRFRRDLGGVEEAYEEVLRRV 231


>UniRef50_C6I122 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6I122_9BACT
          Length = 242

 Score =  276 bits (706), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 94/228 (41%), Positives = 139/228 (60%), Gaps = 1/228 (0%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +LY GKAK +Y+T +P +LV EF++D +A +  +   F  KG +N + +  +   LA  G
Sbjct: 8   KLYEGKAKILYATTDPRILVQEFKDDLTAFNAQKKGTFFGKGALNCQISAVLFELLASRG 67

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           +P     L +    L+ +L+MVP+E VVRNR AGSL KRLGI EG EL+ P+ + + K D
Sbjct: 68  VPVHFRSLETPRRMLIDRLEMVPLEVVVRNRVAGSLAKRLGIPEGEELSFPVVEWYYKRD 127

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK- 184
            + DPMVN  +       S   L +++E+  K N++L   + + G++LVD KLEFG    
Sbjct: 128 DLGDPMVNRDHIRVLKLASDAVLDKIREIALKTNEILLPFYRERGILLVDMKLEFGWNPA 187

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G++VLGDE   D SRLW+ ET  ++DKD FR  LG + E YE +  ++
Sbjct: 188 GDLVLGDEIDGDTSRLWEAETGVRLDKDLFRMDLGSVKEGYEKIYEKV 235


>UniRef50_B9EAY5 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Macrococcus caseolyticus JCSC5402 RepID=PUR7_MACCJ
          Length = 233

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 90/229 (39%), Positives = 143/229 (62%), Gaps = 1/229 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             +Y GKAK VYST+   +  +E++++ +AG+GA+ +    KG +NN    +   +LA  
Sbjct: 2   TLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLARQ 61

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+ +   + LSDTE LVK + ++P+E VVRN AAGS+VKRLG ++G++   PL + + K 
Sbjct: 62  GLESHFIKKLSDTEQLVKAVTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYKE 121

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           DA++DP++ + + +  G    +++A +K      ND+L K+ D+  L L+DFK+EFG   
Sbjct: 122 DALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLVKMMDEMNLQLIDFKIEFGKDQ 181

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G ++L DE SPD  R+WDK+T E  DKD +R+  G LI+ Y     +L
Sbjct: 182 DGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKL 230


>UniRef50_D2EKX6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Pediococcus acidilactici 7_4 RepID=D2EKX6_PEDAC
          Length = 244

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 85/233 (36%), Positives = 132/233 (56%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   +  GKAK +Y+T+  D++ +E+ +  +  +G R +Q   KG +NN+ +  +   
Sbjct: 1   MKKTTLIKEGKAKRLYNTDEADVVWVEYLDQATTLNGKRRDQVIGKGALNNQIDCILFEM 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI T   + +SDTE L  K+D++P+E VVRN AAGS  ++  +    E + P+ + 
Sbjct: 61  LGAKGIHTDFIKKISDTEQLNYKVDVIPLEVVVRNAAAGSFQRKFAVPYLREFDQPIVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DP +N +       +S      ++ L  + N +LK+ F  A L LVDFK+EF
Sbjct: 121 FYKSDELDDPFINTNQAVALKIISYAEGEILENLALQINRLLKEQFWQAHLQLVDFKVEF 180

Query: 181 GL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    G+++L DE SPD  RL D  T   +DKD FR+  G L+  Y+ V RRL
Sbjct: 181 GKTADGKIMLADEISPDSCRLVDLTTKTSLDKDVFRKKTGDLVTVYQEVLRRL 233


>UniRef50_Q3AHS3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=21
           Tax=Bacteria RepID=PUR7_SYNSC
          Length = 250

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 91/233 (39%), Positives = 141/233 (60%), Gaps = 5/233 (2%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK V+++ +PD +++EF+ND +A +  +  Q D KG +N + +  +   L   
Sbjct: 7   ELLYEGKAKRVFASTDPDRVLVEFKNDATAFNAQKKAQLDGKGRLNCQISARLFDLLERE 66

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+PT    L  +T  LV+++ ++P+E V+RN A GSL ++  I EG  + P L DL+ K+
Sbjct: 67  GVPTHYCGLAGETWMLVRRVRIIPLEVVLRNIATGSLCRQTPIAEGTAIEPALLDLYYKD 126

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           D++ DP++ E+  +  G      L+ +++L  + N VL   FD+  L LVDFKLE GL  
Sbjct: 127 DSLGDPLLTEARVQLLGVADTAQLSAIEQLARRVNAVLLPFFDELDLQLVDFKLELGLAS 186

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEK----MDKDRFRQSLGGLIEAYEAVARRL 232
            G ++L DE SPD  RLWD+         +DKDRFR+ LGG++EAY  V +R+
Sbjct: 187 DGTLLLADEISPDTCRLWDRRNSNAEDRILDKDRFRKDLGGVMEAYGEVLKRV 239


>UniRef50_B5IMM2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Cyanobium sp. PCC 7001 RepID=B5IMM2_9CHRO
          Length = 255

 Score =  273 bits (698), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 97/236 (41%), Positives = 144/236 (61%), Gaps = 9/236 (3%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L+ GKAK V++T+ PDL+ +EF++D +A +  +  Q   KG  N + +  +  +LA   
Sbjct: 9   LLHEGKAKRVHATDRPDLVAVEFKDDATAFNALKKAQLSGKGWHNCQISALLFEQLASQD 68

Query: 66  IPTQMERLLS----DTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
           IPT    L          LV+ + ++P+E V+RNRAAGSL +++ I  G  L PPL DL+
Sbjct: 69  IPTHYRGLAEAEHGGNWMLVRPVRIIPIEVVIRNRAAGSLCRQMPIHAGTPLEPPLLDLY 128

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
            K+D + DP++ E+  E    ++ E  A ++ L  + N  L K+FD  GLILVDFK+E G
Sbjct: 129 YKDDGLGDPLLTEARLERLALLTAEERADVERLAREVNTALVKVFDRVGLILVDFKIELG 188

Query: 182 -LYKGEVVLGDEFSPDGSRLWDK---ETLEK-MDKDRFRQSLGGLIEAYEAVARRL 232
               G++V+ DE SPD  RLWD+   +  E+ +DKDRFRQ LGG++EAY  V +RL
Sbjct: 189 YTADGQLVVADEISPDTCRLWDRAVEDVNERILDKDRFRQDLGGVVEAYGQVLKRL 244


>UniRef50_D0JBF3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Blattabacterium RepID=D0JBF3_BLASB
          Length = 242

 Score =  268 bits (687), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 89/237 (37%), Positives = 146/237 (61%), Gaps = 4/237 (1%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  L  GK K +Y+T N   +++ +++  +A DG++ +    KG++NN+ +  I   + 
Sbjct: 6   KKNLLSEGKTKKIYTTNNSLEVLIHYKDSITALDGSKNQFLQDKGILNNEISTLIFKFIN 65

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GI T   R +++ E L  K+D++P+E VVRN  AGS+ KRL I+EGI L  P+F++F 
Sbjct: 66  SCGIKTHFIRKINNREQLCYKVDIIPLEFVVRNIVAGSMSKRLNIQEGIRLLNPIFEIFY 125

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           KND + DP++N+ +    G +S E +  +  +    N++LKK F D  +ILVDFK+EFG 
Sbjct: 126 KNDKLKDPLINDHHAVFLGIISYEEINAIYRIVSNVNNILKKYFLDKNIILVDFKIEFGK 185

Query: 183 YK-GEVVLGDEFSPDGSRLWDKETLEKMDKDRFR---QSLGGLIEAYEAVARRLGVQ 235
               +++L DE SPD  R WDK+T++K+DKD FR   +    +++ Y  + +RL V+
Sbjct: 186 NDQNDILLSDEISPDTCRFWDKKTMKKLDKDPFRIGLKEKEEVLDIYMEILKRLNVR 242


>UniRef50_A4FYT6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=11
           Tax=cellular organisms RepID=A4FYT6_METM5
          Length = 245

 Score =  268 bits (685), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 93/236 (39%), Positives = 141/236 (59%), Gaps = 2/236 (0%)

Query: 1   MQKQAELYRGKAKTVYSTE-NPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           +  +  +Y GKAK++Y  E N   +++EFR+D +AG+GA+ +    KG +N   +  +  
Sbjct: 8   ITAKEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNTLISNELFK 67

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L +  +PT +   +     + K + ++P+E +VRN AAGSL K+   E+G  L   +  
Sbjct: 68  ILEQNNVPTHLIEYIEPNHMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQVLKTAVTQ 127

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              KND   DPM+N       G  ++E L  +K+L  K NDVLK  FD+ G+ILVDFK+E
Sbjct: 128 FDYKNDDYGDPMLNNEITIELGLATEEELVEIKKLALKVNDVLKGFFDEKGIILVDFKIE 187

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
            G    G++V+ DE SPD  RLWDKET + +DKD FR+ LG ++E Y+ VA+R+G 
Sbjct: 188 VGKTVDGDIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKTVAKRIGC 243


>UniRef50_Q7V0C7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Prochlorococcus marinus RepID=PUR7_PROMP
          Length = 242

 Score =  267 bits (683), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 92/237 (38%), Positives = 138/237 (58%), Gaps = 5/237 (2%)

Query: 2   QKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL 61
            K   +Y GKAK +++ E+ D +++EF++D +A +  +  +F+ KG +N   +  I   L
Sbjct: 3   SKLKFIYEGKAKKIFAYEDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFEFL 62

Query: 62  AEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
            +  IPT    L ++   + +K+ ++P+E V+RN A GSL K+  I+ G  L  PL D +
Sbjct: 63  IKNNIPTHYIGLKNNNSMIAQKIKIIPLEVVLRNTAYGSLCKQTTIKPGTVLESPLIDFY 122

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
           LKND ++DP++ +        V +E L  +  +T K N +LKK F +  L LVDFKLEFG
Sbjct: 123 LKNDTLNDPLLTKDRINLLKIVDEEELDFISNMTLKINKLLKKFFYNIKLDLVDFKLEFG 182

Query: 182 L-YKGEVVLGDEFSPDGSRLWDKETLE----KMDKDRFRQSLGGLIEAYEAVARRLG 233
               G++VLGDE SPD  RLWD          +DKDRFR  LGG IEAY  + +R+ 
Sbjct: 183 YNSNGQIVLGDEISPDNCRLWDLNQKNGMIVSLDKDRFRNDLGGFIEAYSEINKRIN 239


>UniRef50_A9BIH1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Petrotoga mobilis SJ95 RepID=A9BIH1_PETMO
          Length = 238

 Score =  267 bits (683), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 84/235 (35%), Positives = 129/235 (54%), Gaps = 3/235 (1%)

Query: 2   QKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL 61
           +    LY GKAK VY  +   LL+ EF++D +A +G + +Q   KG +N + + F    L
Sbjct: 5   KNFELLYEGKAKKVYKFDEKKLLI-EFKDDVTAFNGLKKDQILNKGKINKEISKFFFEML 63

Query: 62  AEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
              GI T       +   + K  D++P+E ++RN  AG   KR G+++G+  + PL +  
Sbjct: 64  NNQGINTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLVEFS 123

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
           LKND + DPM+ +         ++  L  +  ++ K N++L       G+ILVDFKLEFG
Sbjct: 124 LKNDELGDPMIAKDAILLLKITTENVLDEIASISKKVNNILSDYLKSKGIILVDFKLEFG 183

Query: 182 LY--KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           +     +V L DE SPD  R WD  T+E +DKD +R++ G LI AYE +  RL +
Sbjct: 184 ISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI 238


>UniRef50_O26272 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Euryarchaeota RepID=PUR7_METTH
          Length = 248

 Score =  267 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 97/229 (42%), Positives = 135/229 (58%), Gaps = 1/229 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK V  T++P+++ + FR+D +AGDG + +  + KG  N+  +  I   L EA
Sbjct: 7   GPLYSGKAKDVLLTDDPEIVAVRFRDDITAGDGEKKDTLEMKGYYNSVISAKIFEVLEEA 66

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+PTQ   L      L +KL+M+P+E + RN AAGS+V+R    EG E  PPL  +  K+
Sbjct: 67  GVPTQYLELREPGCILARKLEMIPIEVITRNIAAGSIVRRFPFTEGQEFVPPLIQMDYKS 126

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           D   DPM+N+      G  +++ L  ++ +T   N VL+      GLIL DFKLEFG   
Sbjct: 127 DEHGDPMLNDDIILALGIATRDELEEIRRITLHINSVLRDFLKSRGLILPDFKLEFGRDS 186

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G + LGDE SPD  RLWD ET E +DKD FR+   G++ AY  VAR +
Sbjct: 187 SGRIRLGDEVSPDTCRLWDMETGEPLDKDIFRRGEEGVVGAYRRVARMI 235


>UniRef50_Q03Y92 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=Leuconostocaceae RepID=Q03Y92_LEUMM
          Length = 249

 Score =  254 bits (650), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 76/232 (32%), Positives = 127/232 (54%), Gaps = 1/232 (0%)

Query: 2   QKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL 61
            +    Y+GKAK VY T+NP +L + + +  +A +G   E    KG +N+  ++ +   L
Sbjct: 13  TRGELKYQGKAKQVYFTDNPTILWVHYMDQATALNGKVHENIPEKGQLNSAISHILFEHL 72

Query: 62  AEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
              GI       +S+T+ L   LD++P+E V RN A+G  V +       +L P + + +
Sbjct: 73  TRQGIENHYLSSVSETDELDLALDILPIEVVTRNYASGHFVSKFNATPMQKLTPVVQEFY 132

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
            K+D + DP +N+S     G+ +   L +++    + N  L ++FD+  + LVDFKLE+G
Sbjct: 133 YKSDELDDPFMNDSQILALGFATLSELTKLRAYAQEVNQALTEIFDEININLVDFKLEYG 192

Query: 182 LY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
              +G+++L DE SPD  RL D++T + +DKD FR+  G +   Y  V  RL
Sbjct: 193 RDSEGKLILADELSPDNMRLVDQKTGKSLDKDVFRKHAGDVTVGYRDVLSRL 244


>UniRef50_B8D414 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Desulfurococcus kamchatkensis 1221n
           RepID=B8D414_DESK1
          Length = 253

 Score =  253 bits (646), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 90/238 (37%), Positives = 141/238 (59%), Gaps = 6/238 (2%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +   LY GK K VYS + P+LLVLEF++D +A DG   +    KG++N + + ++   + 
Sbjct: 12  ELKLLYEGKTKRVYS-KTPELLVLEFKDDVTAMDGLVKKTMPGKGVINARLSAYLFKHIE 70

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFDLF 121
           + GI T +     D    V++L+M+P+E +VRN A GSL+KR+ + ++  ELNPPL +  
Sbjct: 71  KQGIETHLVEYNGDRFLTVRRLEMLPIEVIVRNYAYGSLLKRMPLYKKMQELNPPLVEFH 130

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
            K+D++HDP++        G ++   L  + E T K N+VL +LF  AGL LVDFK+E+G
Sbjct: 131 YKDDSLHDPLITPEDITYTGLLTSGELRWLIEATIKINNVLSELFSGAGLKLVDFKVEYG 190

Query: 182 L-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQ--SLGGLIEAYEAVARRLGVQL 236
               G ++LGDE + D  R+ D +    +DK+ FR+   +  L  AY  +  RLGV +
Sbjct: 191 RNRNGRLILGDELTGDSIRVLDDKGN-HLDKEVFRKTGDIEALRTAYIELCNRLGVNV 247


>UniRef50_Q8D2M4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=46
           Tax=Gammaproteobacteria RepID=PUR7_WIGBR
          Length = 240

 Score =  253 bits (646), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 118/238 (49%), Positives = 176/238 (73%), Gaps = 1/238 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           ++K+ ++Y+GK+K +YST N D+L+L+F+ D S  +G  I++FD K ++NNKFNY+IM+K
Sbjct: 3   IKKKNKIYQGKSKIIYSTNNSDVLILKFKKDMSRLNGKYIKKFDNKDIINNKFNYYIMNK 62

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           ++   I T +  LLSD + +VKKL M+P+E VVRN A GSL+KR  I+E   +NPP+ + 
Sbjct: 63  ISSFNIKTHILSLLSDNQVIVKKLKMIPIEFVVRNYAYGSLLKRFLIKERSFINPPILEF 122

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F KND + DPM+NE +C +F  +S+ ++ ++K++ YK N++LK +F  A LILVDFKLEF
Sbjct: 123 FFKNDGLKDPMINEYHCISFNLISENHIKKIKKILYKINNILKDIFYKAELILVDFKLEF 182

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLG-GLIEAYEAVARRLGVQLD 237
           GL+ G++ LGDEFS D SR+WDK + +KMDKD FR+ L   +IE+Y+ VA R+G  +D
Sbjct: 183 GLFNGDLFLGDEFSLDNSRVWDKNSFKKMDKDIFREQLNENVIESYKEVANRIGCLID 240


>UniRef50_C2U7A6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Bacillus cereus RepID=C2U7A6_BACCE
          Length = 239

 Score =  251 bits (642), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 83/234 (35%), Positives = 129/234 (55%), Gaps = 4/234 (1%)

Query: 1   MQKQAELYR-GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M K   LY  GK+K++Y  E  D +++ F +  S+    +  +    G++  +F+  I  
Sbjct: 1   MTKNGLLYTCGKSKSMYYGEENDSIIMHFLDSVSSYTQNKNARIIGTGILRCEFSSHIFE 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L + G+P      +      V KLDM+ +E + RN AAGS+V+   I+ G   N P+  
Sbjct: 61  LLHKKGVPNHYISNIGMGRMKVNKLDMIKLEIIPRNIAAGSIVRNYPIQYGQVFNQPILK 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
           L LK    +DPM+N  Y    G  +K  +  ++E+ ++ N +LK    + G+ LVDFK E
Sbjct: 121 LDLKYS--NDPMMNSDYIVAMGIATKREIEVIREIAFELNAILKDFLLERGVKLVDFKFE 178

Query: 180 FGL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G    G++V+GDE SPDG RLWD ET + +DKD FR + G L+ AYE + +R+
Sbjct: 179 MGRNAAGDLVIGDEISPDGMRLWDIETNQSLDKDVFRYNKGDLVHAYEEILKRI 232


>UniRef50_C6XGE3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Alphaproteobacteria RepID=C6XGE3_LIBAP
          Length = 255

 Score =  246 bits (630), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 81/238 (34%), Positives = 128/238 (53%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+ +  +Y  K K +Y    P  L+  F++D    +  R    + KG++NN+ + ++ ++
Sbjct: 1   MRPRNPVYEEKTKIIYEGLEPGTLIQFFKDDNLLENNPRCATLNGKGVLNNRISEYMFTQ 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L + GIP    R ++  E LV+ ++M+P+   VRN AAGSL KRL I EG+ L   L + 
Sbjct: 61  LGKIGIPHYFIRRINMREQLVRDVEMIPLLITVRNTAAGSLAKRLNIPEGLSLPRSLVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           +   D+    +V+E +   F W ++  +  M  L+ + ND +  LF    + LVDF+++ 
Sbjct: 121 YYLPDSSEKTLVSEEHITAFNWANQSEVEEMTALSIRINDFMTGLFLGINIQLVDFRIKC 180

Query: 181 GLYKG----EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G         +VL DE  PD  RLWD    E+ DK RF +S   L+E Y  VARRLG+
Sbjct: 181 GRLLDDDILRIVLADEIFPDCCRLWDLSKKEECDKKRFSKSNDQLLEGYSEVARRLGI 238


>UniRef50_A8MCJ8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Caldivirga maquilingensis IC-167 RepID=PUR7_CALMQ
          Length = 241

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 89/238 (37%), Positives = 129/238 (54%), Gaps = 7/238 (2%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +   +Y GKAK VY   N + LV+EF+++ +A DGAR E    KG +      F MS L 
Sbjct: 5   EGKLIYEGKAKRVYLINNEE-LVMEFKDEVTALDGARKEYAPGKGKLAASQTAFFMSYLN 63

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG-IEEGIELNPPLFDLF 121
           E+G+ T       D    V++L M+PVE +VRN A GS ++R+  I+   +   PL +  
Sbjct: 64  ESGVRTHFINWDGDRRIHVRRLRMIPVEVIVRNYAYGSFIRRMPLIKPLTKFTTPLVEFH 123

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
           LKND +HDP++        G  S E +  ++ ++ K N +L +L    GL LVDFKLEFG
Sbjct: 124 LKNDELHDPLILIEDIIEAGLTSMEQVMEIRSVSLKVNHLLSELLGKYGLTLVDFKLEFG 183

Query: 182 L-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQS--LGGLIEAYEAVARRLGVQL 236
           +   G +VL DE S D  R+      + +DK+ FR    +  LIEAY  +   LG+ L
Sbjct: 184 VNSNGALVLADELSGDTMRV--LMNGKHLDKELFRMGGSVKELIEAYSRLNSILGLGL 239


>UniRef50_P22234 Phosphoribosylaminoimidazole carboxylase n=88 Tax=Metazoa
           RepID=PUR6_HUMAN
          Length = 425

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 18/250 (7%)

Query: 5   AELYRGKAKTVYST-ENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
            +LY GK K VY   ++P  ++L+ ++  +AG+ AR    + K  ++NK    I   L E
Sbjct: 11  KKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQE 70

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFDLFL 122
           AGI T   R   +T  +  + +M+P+E V R  A GS +KR  G++EG +  PP  +LF 
Sbjct: 71  AGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFF 130

Query: 123 KNDAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLILVDF 176
           K+DA +DP  +E              + +  +  M   T    ++L+K +      LVD 
Sbjct: 131 KDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDM 190

Query: 177 KLEFGLY--KGEVVLGDEFSPDGSRLWDKETL-EKMDKDRFR-------QSLGGLIEAYE 226
           K+EFG+     E+VL D    D  RLW      ++ DK  +R       + L  + + +E
Sbjct: 191 KIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFE 250

Query: 227 AVARRLGVQL 236
            VA R+ + L
Sbjct: 251 WVAERVELLL 260


>UniRef50_B8GCM2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Chloroflexi (class) RepID=PUR7_CHLAD
          Length = 250

 Score =  240 bits (614), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 105/237 (44%), Gaps = 7/237 (2%)

Query: 1   MQKQAELYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M+    L  GK K VY    +PDL +L  ++  +AGDGAR      KG +  +    +  
Sbjct: 1   MELGHVLSEGKTKIVYAHPTDPDLAILFHKDGITAGDGARRHVIAGKGALAGQTTANVFR 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L  AGI T           +V++  M+P+E V+R   AGS ++R     G   +PPL +
Sbjct: 61  FLNRAGIATHFIEAPEPKLTVVRRCVMIPLEVVMRRLPAGSYLRRYPEAAGQRFDPPLVE 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
            FLK+DA HDP +        G  +   + +M     +    L+  +    + LVD K+E
Sbjct: 121 FFLKDDARHDPQITPDEIVAQGIATPAEVEQMTMTGQQVFTTLEAAWAKLDVTLVDLKIE 180

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEK-MDKDRFRQ----SLGGLIEAYEAVAR 230
           FG    G +++ D    D  R+W      + +DK  +R         L + Y   A+
Sbjct: 181 FGRAGDGSLLVADVIDNDSWRIWPGGDPNRMLDKQVYRNAQVVDEDVLADVYARYAQ 237


>UniRef50_Q4J8G0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=Sulfolobaceae RepID=PUR7_SULAC
          Length = 235

 Score =  236 bits (604), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 81/229 (35%), Positives = 132/229 (57%), Gaps = 4/229 (1%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             +  GK K VY   +P+  +L F++  +AGDGAR ++   KG +N + +      L + 
Sbjct: 4   KRVAEGKTKIVYEF-DPEHYLLRFKDSITAGDGARKDELPGKGTLNAQTSALFFRLLEKN 62

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
            I T    +  +   +V KL M+PVE V+RN A GS+VKRL I+EG   +PP+ + FLK+
Sbjct: 63  DIRTHYVGMYDEKTMIVTKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFDPPIVEFFLKD 122

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           D  HDP++N S+ + F  ++++    ++E+  K N V+K    + GL+L D KLEFG   
Sbjct: 123 DLRHDPLLNYSHLQYFNLLTRKEAEIVEEVIVKVNAVMKNFLKERGLVLYDLKLEFGKDK 182

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQS--LGGLIEAYEAVAR 230
              +++GDE + D  R+ D++T + +DKD +R+   L  + +AYE    
Sbjct: 183 DNNLIVGDEITLDSMRVRDEKTNKILDKDLYRKGESLEVVKKAYEDFFN 231


>UniRef50_B1LCA5 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Thermotogaceae RepID=PUR7_THESQ
          Length = 230

 Score =  233 bits (595), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 89/224 (39%), Positives = 119/224 (53%), Gaps = 5/224 (2%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK K V  T   D  +LEF++D +AGDG + +    KG +  +    +M  L+E  I 
Sbjct: 3   YEGKTKIVKVT--GDYALLEFKDDITAGDGLKHDVLTGKGSICAETTAILMKYLSEKDIK 60

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAM 127
           T +   +      V  L M P+E VVR + AGS V+R G  EG +L  PL + F+K+D  
Sbjct: 61  THLVEYIPPRTLKVIPLKMFPLEVVVRLKKAGSFVRRYGGAEGEDLPVPLVEFFIKDDER 120

Query: 128 HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGE 186
           HDPMV   + E  G  +K+   +MKE   K    LK+ F+ A   L D K EFGL   G 
Sbjct: 121 HDPMVCVDHLEILGIATKKQAEKMKEAAVKITLALKEFFERANFELWDIKYEFGLDKDGN 180

Query: 187 VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVAR 230
           VVLGDE SPD  RL +K   E  DKD +R+ LG  ++ Y  V  
Sbjct: 181 VVLGDEISPDTFRLRNK--GEIFDKDVYRRDLGDPLKKYREVLE 222


>UniRef50_UPI00006A4774 PREDICTED: similar to phosphoribosylaminoimidazole carboxylase,
           phosphoribosylaminoribosylaminoimidazole
           succinocarboxamide synthetase n=1 Tax=Ciona intestinalis
           RepID=UPI00006A4774
          Length = 471

 Score =  231 bits (591), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 70/243 (28%), Positives = 117/243 (48%), Gaps = 19/243 (7%)

Query: 9   RGKAKTVYS--TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
            GK K VY   T+ P   ++  ++  +AGDGA+    + K  +++  N  +M  L + G+
Sbjct: 58  EGKTKVVYEINTKTPGRCLIVSKDIITAGDGAKRNVMEGKAELSSATNAAVMQMLNDFGL 117

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-GIEEGIELNPPLFDLFLKND 125
            T   + ++    L  K DM+P+E V R  A GS ++R  G++EG   +PP  + F K+D
Sbjct: 118 KTAFIKGVNKKSFLAWKCDMIPIEWVARRVATGSFIRRHVGVKEGYRFSPPKLETFYKDD 177

Query: 126 AMHDPMVNESYCETFGW------VSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
             HDP  +    E          V+ + +  M+++T    +VL+K +    + L+D K+E
Sbjct: 178 ENHDPQWSREVLEEAKLKCGKIVVTPDLIDIMEKMTITIFEVLEKAWKSKNVSLIDMKIE 237

Query: 180 FGLYK--GEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIEAYEAVA 229
           FG+ +   E+VL D    D  R+W       M DK  +R         +  L E Y  V+
Sbjct: 238 FGVRQDTNEIVLADVIDNDSWRIWPSGDKRLMKDKQVYRNLKEVTNGDMQNLKENYTWVS 297

Query: 230 RRL 232
            +L
Sbjct: 298 NQL 300


>UniRef50_A3MXE4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Thermoproteaceae RepID=PUR7_PYRCJ
          Length = 240

 Score =  226 bits (577), Expect = 5e-58,   Method: Composition-based stats.
 Identities = 72/233 (30%), Positives = 116/233 (49%), Gaps = 7/233 (3%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M     +Y GKAK VY T     L++ F+++ +AGDGAR ++   KG +  + +  +   
Sbjct: 1   MGFMELVYEGKAKAVYKTREG--LLMVFKDEVTAGDGARRDKAPGKGALAAETSTLLFQY 58

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG-IEEGIELNPPLFD 119
           L   G+ T     +     LVK   + P+E +VR +A GS +KR+   +       P+ +
Sbjct: 59  LQGRGVTTHYLMFVPPNAILVKPAQVPPLEVIVRFKAYGSYLKRMPKAKPLTPFAKPIVE 118

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K+D++HDP++ E      G ++   LA +K++  +A   L++L+       VD K E
Sbjct: 119 FHYKDDSLHDPLILEDDVVEAGLLTAGELAAVKDMALRAASALRELYASVDCDFVDVKFE 178

Query: 180 FGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQ--SLGGLIEAYEAVAR 230
           FG   GE+VL DE S D  RL      E  DK+ +R+     GL+E Y  +  
Sbjct: 179 FGRVGGELVLVDEVSGDTFRLLC--GGEHFDKEYYRKTGDAVGLVERYAKLLE 229


>UniRef50_Q648Z8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=uncultured archaeon GZfos35D7 RepID=Q648Z8_9ARCH
          Length = 249

 Score =  226 bits (576), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 73/242 (30%), Positives = 120/242 (49%), Gaps = 22/242 (9%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           GK+K ++  E       EF + T+A DG + ++F  KG V  + + +    L EAGIPT 
Sbjct: 9   GKSKDIF--EEDGKTFFEFTDRTTAFDGVKEDEFSHKGEVCCRLSTYWFEILEEAGIPTH 66

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEE----------GIELNPPLFD 119
               +      V+ LD++P+E + RN  AGS+++R    E          G  +   + +
Sbjct: 67  FRAFVPPNIMEVEPLDILPIEVIWRNFVAGSILRRHERGESLPIEIEPRLGARIPGGMVE 126

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K +A   P ++E      GW++   L  ++E T   N+++ +     G+IL DFK+E
Sbjct: 127 FTTKFEAKDRP-IDEQEILDNGWLTSAELDSIRECTRLTNEIMSERLLKRGIILADFKIE 185

Query: 180 FGLYKG---EVVLGDEF-SPDGSRLWDKETL-----EKMDKDRFRQSLGGLIEAYEAVAR 230
           FG  K    +++L DE  +PDG R WD++       E +DKD +R   G L + Y  + R
Sbjct: 186 FGRDKNAAEKILLADEVGTPDGCRFWDRDAYEQGVIESLDKDVYRYDKGDLSDVYLRIQR 245

Query: 231 RL 232
           R+
Sbjct: 246 RI 247


>UniRef50_A8ZVI6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=15
           Tax=Bacteria RepID=PUR7_DESOH
          Length = 293

 Score =  224 bits (572), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 61/253 (24%), Positives = 99/253 (39%), Gaps = 41/253 (16%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L RGK + VY     D L++   +  SA D    +    KG +  + + F   ++ + 
Sbjct: 14  NLLKRGKVRDVYDF--GDRLLIVATDRLSAFDVVMPDPIPGKGEILTQISLFWFDQVKDI 71

Query: 65  GIPTQME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
            +   +                  L+    LV K + + +ECVVR   +GS  K      
Sbjct: 72  -VRNHLISSDVNDYPEACRPYAETLAGRSMLVTKTEPLAIECVVRGYLSGSGWKSYQKDR 130

Query: 106 ---------GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMKELT 155
                    G+ E   L  P+F    K +A  HD  ++    E      +E   + ++L+
Sbjct: 131 TVCGISLPDGLRESDRLPEPIFTPSTKAEAGQHDINISFD--EAANIAGRETTEKARDLS 188

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL------EK 208
                   ++ D  G+I+ D K EFG   GE++L DE  +PD SR W ++        + 
Sbjct: 189 LAIYRRGVEVADARGIIIADTKFEFGFVDGELILIDEVLTPDSSRFWPRDGYAPGGPQQS 248

Query: 209 MDKDRFRQSLGGL 221
            DK   R  L  L
Sbjct: 249 FDKQYVRDYLLSL 261


>UniRef50_A9VBB9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Monosiga brevicollis RepID=A9VBB9_MONBE
          Length = 368

 Score =  224 bits (571), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 70/251 (27%), Positives = 113/251 (45%), Gaps = 24/251 (9%)

Query: 5   AELYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
             +  GK K V+    N D ++L  ++  +AGDGAR  +   K  V N     I   L  
Sbjct: 6   KTIVEGKTKVVHQHARNFDQVILVSKDRITAGDGARAHEISGKAKVANDTTCTIFEFLNS 65

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR----LGIEEGIELNPPLFD 119
            GIP+       D   + KK+ M+P+ECV R  A GS ++R      + E      P  +
Sbjct: 66  VGIPSHFVARSGDM-MVAKKVHMIPIECVARRVAYGSYLRRFKTPFPVTEAYRFPTPCLE 124

Query: 120 LFLKNDAMHDPMVNESYCETFGW---------VSKENLARMKELTYKANDVLKKLFDDAG 170
            F K+DA HDP V +    +            ++ + + +M+  T    + L++ +   G
Sbjct: 125 FFYKDDANHDPQVTKEQLLSNPLLLDEAKQLRLTPKYVEQMELWTRAVFETLERAWAVQG 184

Query: 171 LILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGL 221
             LVD K+EFG+  +G ++L D    D  R+W +     M DK  +R+        L  +
Sbjct: 185 CTLVDMKIEFGIDMQGRLILADVIDNDAWRVWPQGDRRLMKDKQFYRELKTVTDADLTEV 244

Query: 222 IEAYEAVARRL 232
           ++ YE VA  +
Sbjct: 245 LKKYEWVADAV 255


>UniRef50_A8AAS3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ignicoccus hospitalis KIN4/I RepID=A8AAS3_IGNH4
          Length = 235

 Score =  222 bits (567), Expect = 7e-57,   Method: Composition-based stats.
 Identities = 87/232 (37%), Positives = 134/232 (57%), Gaps = 9/232 (3%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             +Y GK K VY  +  D ++L+F++  +A DG ++E+   KG VN +F   +M  L + 
Sbjct: 2   KLIYEGKTKKVYDMD--DKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQH 59

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFDLFLK 123
           G+ T      ++ E +  K   +P+E +VRN A GSL+KRL I E+G  L  P+F++  K
Sbjct: 60  GVKTHFLSR-NEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYK 118

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           +D +HDP++ E      G VSK+ +  ++E T K N++L +LF+ AG  L+DFK+E+G+ 
Sbjct: 119 SDELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDFKVEYGIT 178

Query: 184 -KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGG--LIEAYEAVARRL 232
             G VVL DE SPD  R    +  E  DKD FRQ   G  +++ Y  +   L
Sbjct: 179 EDGRVVLIDELSPDSFRA--HKGGEAYDKDLFRQGASGEEVLKKYVELLEAL 228


>UniRef50_B4Q3U0 GD23841 n=2 Tax=melanogaster subgroup RepID=B4Q3U0_DROSI
          Length = 413

 Score =  222 bits (566), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 65/243 (26%), Positives = 103/243 (42%), Gaps = 17/243 (6%)

Query: 7   LYRGKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           L  GK K VY   + P L +L  ++  +A DG +  +   K  ++N  N  +   L EAG
Sbjct: 15  LIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLKAHELQGKAAISNTTNGLVFRLLNEAG 74

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-RLGIEEGIELNPPLFDLFLKN 124
           I T       D   + +K  MVP+E V R  A GS +K    + EG    PP  +   K+
Sbjct: 75  IRTAYVDQCGDNAFIARKCKMVPIEWVTRRLATGSFIKINPEVPEGYRFAPPKQETCFKD 134

Query: 125 DAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL 178
           D+ HDP+  +    +         +  + +  M+  +    +VL++ +      LVD K+
Sbjct: 135 DSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRHTSLVVFEVLERAWKTRNCALVDMKV 194

Query: 179 EFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIEAYEAVA 229
           EFG+   G ++L D    D  R+W       M DK  +          L  +   Y  V 
Sbjct: 195 EFGVDEDGNILLADIIDSDTWRIWPAGDKRLMVDKTVYINLDTVTDGDLNTVKRNYFWVI 254

Query: 230 RRL 232
            +L
Sbjct: 255 EQL 257


>UniRef50_C1A3U9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Bacteria RepID=C1A3U9_GEMAT
          Length = 314

 Score =  222 bits (566), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 61/252 (24%), Positives = 104/252 (41%), Gaps = 42/252 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            + RGK + VY+ ++ D L++   +  SA D    E    KG V  +   + +++LA   
Sbjct: 15  LVRRGKVRDVYAVDD-DRLLMVTTDRISAFDVVMHEAIPYKGAVLTQVTAWWLAQLAGM- 72

Query: 66  IPTQME------------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
           +   +                     L+    L  + D+VP+ECV+R    GS  K    
Sbjct: 73  VDHHLITAETDEIIAAVPSLAPYRDALAGRSMLTVRADVVPIECVIRGYITGSAWKEYRE 132

Query: 106 -----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKEL 154
                      G++E   L+PP+F    K +  HD  +  S   +   V  +  A+++ L
Sbjct: 133 HGTLAGEALKAGLQESDRLDPPIFSPATKAETGHDENITVSKVISE--VGADTAAQLESL 190

Query: 155 TYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE------ 207
             +  +  +   +  G+I+ D K EFG   G+++L DE  +PD SR W  ++        
Sbjct: 191 ARRIYEYGRATAEPRGIIVADTKFEFGWRDGKLLLIDEVLTPDSSRFWPADSYAPGRGQP 250

Query: 208 KMDKDRFRQSLG 219
             DK   R  L 
Sbjct: 251 SFDKQPLRDWLD 262


>UniRef50_Q47KH4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=226
           Tax=Bacteria RepID=PUR7_THEFY
          Length = 307

 Score =  221 bits (565), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 63/257 (24%), Positives = 106/257 (41%), Gaps = 35/257 (13%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L+ GK + +Y+TE+ + LV+   +  SA D     +   KG +  + + +   +L++ 
Sbjct: 17  THLHTGKVRDLYATESGE-LVMVASDRVSAFDWVLPTEIPDKGRLLTQLSLWWFDQLSDI 75

Query: 65  GIPTQMERLLSD---------TECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
            I   +                  + ++LDMVPVECV R    GS +             
Sbjct: 76  -IDNHVISDTPPPGAPDDWAGRTLVCRRLDMVPVECVARGYLTGSGLAEYTATGAVCGVR 134

Query: 106 ---GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDV 161
              G+ +G  L+PP+F    K +   HD  V+                R++E+T    + 
Sbjct: 135 LPEGLVDGSRLDPPIFTPATKAEVGEHDENVSLETVAERH--GPALAERLREVTLALYER 192

Query: 162 LKKLFDDAGLILVDFKLEFGLY-KGEVVLGDE-FSPDGSRLWDKETLE------KMDKDR 213
            +++ ++ G++L D K EFG    G +VL DE  +PD SR W KE           DK  
Sbjct: 193 GREIAEERGILLADTKFEFGWDSDGSLVLADEVLTPDSSRFWPKEEWRPGRPQPSFDKQI 252

Query: 214 FRQSLGGLIEAYEAVAR 230
            R  L      ++  + 
Sbjct: 253 IRDWLSSAESGWDRTSE 269


>UniRef50_A5CCM2 Phosphoribosylaminoimidazole-succinocarboxamidesynthase n=2
           Tax=Orientia tsutsugamushi RepID=A5CCM2_ORITB
          Length = 252

 Score =  221 bits (564), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 63/235 (26%), Positives = 120/235 (51%), Gaps = 6/235 (2%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           + +++ G +K +Y  +    L+  F++D    +  ++ Q   KG++NN  + +I  +++ 
Sbjct: 14  KEKIFEGNSKIIYRIDEH-TLIQFFKDDMR-INAEKVIQVSGKGVLNNVISNYIFKRVSM 71

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
            GI   + + ++  E L+  L+++PV+  + N A+G  V + GIE+G   + P+ D  +K
Sbjct: 72  VGINHHLIQKINMREQLIYTLNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDFMVK 131

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           + A + P++NE     F WV    L  +K L  K    L  +F    + LV+ +LEFG  
Sbjct: 132 HGANNYPIINEDQMIKFNWVDYYELKNIKTLALKLYTFLVGMFASINIRLVECQLEFGRI 191

Query: 184 KG----EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
                  ++L DE +PD  +LWD ++  K+  +R    L   I  Y+ + +R  +
Sbjct: 192 NNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNL 246


>UniRef50_D0MIB5 Phosphoribosylaminoimidazolesuccinocarboxamidesy nthase n=18
           Tax=Bacteria RepID=D0MIB5_RHOM4
          Length = 328

 Score =  220 bits (562), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 57/227 (25%), Positives = 93/227 (40%), Gaps = 23/227 (10%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           YRGK + VY+ +    LV+   +  SA D    +    KG V N+   +     A+  +P
Sbjct: 27  YRGKVRDVYTVD--GHLVIVTTDRISAFDHILRQTIPFKGQVLNQLAAYFFRHTADL-VP 83

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEGIEL 113
             +E +      + ++   +P+E VVR   AG   +                G+ +   L
Sbjct: 84  NHVEAVPDPNVTVARRCRPIPIEFVVRGYLAGHAWRVYRSGRRELCGKKLPEGLVQNARL 143

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
             P+     K    HD  ++       G +  E   R++ +T        ++    GLIL
Sbjct: 144 PEPILTPATKAKEGHDEDISREEIIARGLLDAETFDRIEVMTLALYRRGAEMAARRGLIL 203

Query: 174 VDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLEKMDKDRFRQSL 218
           VD K EFG+   G + L DE  +PD SR +  +  E    +R R+ L
Sbjct: 204 VDTKYEFGIDDEGMIRLIDEVHTPDSSRYFYADEYE----ERLRKGL 246


>UniRef50_A8GML2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=16
           Tax=Proteobacteria RepID=PUR7_RICAH
          Length = 236

 Score =  220 bits (560), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 72/233 (30%), Positives = 121/233 (51%), Gaps = 5/233 (2%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           + ++Y+G +K +YS E   LL++ F ++     G  IE    KG++NN  + F+M KL  
Sbjct: 2   KTQIYKGSSKILYSAEEDFLLIMAFSDNGILESGEIIE-VSGKGVLNNNISSFLMDKLEM 60

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
            GI       ++  E L++ +++ PV+ ++ + A G  VK  G++EG   + P+ D  ++
Sbjct: 61  IGIENHFIEKINMREQLIQYVEVFPVQVIISSVACGRFVKEFGMDEGYVFDKPIIDFKVR 120

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           +     P+VNE     F W++ + +  +KE   +    L  LF   G+ LV+ KLEFG  
Sbjct: 121 SREFKYPIVNEYQILNFSWLTLDEIKAVKEQALRIYAFLSGLFMGVGIRLVECKLEFGRV 180

Query: 184 -KGE---VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             GE   ++L DE SPD  RLW   + EK+  +          E+Y+ +A RL
Sbjct: 181 LNGEESIIMLTDEISPDNCRLWHIHSNEKLGFELLENKPNKAFESYQLIADRL 233


>UniRef50_A6LDF8 Phosphoribosylamidoimidazole-succinocarboxamide synthase n=19
           Tax=Bacteroidetes RepID=A6LDF8_PARD8
          Length = 316

 Score =  219 bits (559), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 58/242 (23%), Positives = 96/242 (39%), Gaps = 28/242 (11%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +Q  +Y GK + VY+  + ++LV+   +  SA D    E    KG + N+     +    
Sbjct: 14  RQKSVYHGKVRDVYNIND-EVLVMVATDRISAFDVILPEGIPYKGQMLNQIAAKFLDATT 72

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIE 108
           +   P            +  +    PVE +VR    GS  +                G+ 
Sbjct: 73  DIC-PNWKMATPDPMVTVGVQCQGFPVEMIVRGYLCGSAWRAYKSGVREICGVKLPEGMR 131

Query: 109 EGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
           E      P+     K +   HD  +++      G VSKE+   +++ T        ++  
Sbjct: 132 ENQRFPEPIITPTTKAEIGEHDQDISKEEILAKGLVSKEDYEVLEKYTMALFKRGTEIAK 191

Query: 168 DAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQ 216
           + GLILVD K EFG   G++ L DE  +PD SR +  E  E          ++ K+  R+
Sbjct: 192 ERGLILVDTKYEFGHRDGKIYLIDEIHTPDSSRYFYSEGYEDRFAKGEPQKQLSKEFVRE 251

Query: 217 SL 218
            L
Sbjct: 252 WL 253


>UniRef50_C4FB69 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Collinsella intestinalis DSM 13280
           RepID=C4FB69_9ACTN
          Length = 322

 Score =  218 bits (557), Expect = 9e-56,   Method: Composition-based stats.
 Identities = 64/248 (25%), Positives = 103/248 (41%), Gaps = 41/248 (16%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y  +  D L++   +  SA D    ++   KG V ++ + F   KLA+  +P 
Sbjct: 25  QGKVRDIY--DAGDSLLMVASDRISAFDYILPDEIPYKGEVLSRISAFWFEKLADV-VPN 81

Query: 69  Q---------------MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-------- 105
                            E  LS    LV+K + + +ECVVR    GS+ +          
Sbjct: 82  HLVSMDPRDFPAEFLPYEEYLSGRAMLVRKAEPIKIECVVRGYLTGSIKEAYDATGEVDG 141

Query: 106 -----GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMKELTYKAN 159
                G+ E   L  PLF    K D   HD  ++   C     + ++  +++++L+    
Sbjct: 142 IALPAGLVEASPLPEPLFTPSTKADVGDHDENISYERCVEL--IGEDLASQIRDLSISLY 199

Query: 160 DVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEK------MDKD 212
               +     G+I+ D K EFG+  G V L DE  +PD SR WD  + E+       DK 
Sbjct: 200 TEAARYARTRGIIIADTKFEFGIIDGRVTLIDECLTPDSSRFWDAASYEEGKVQPGYDKQ 259

Query: 213 RFRQSLGG 220
             R  L  
Sbjct: 260 YVRDWLKD 267


>UniRef50_Q9VK80 CG17024 n=4 Tax=melanogaster group RepID=Q9VK80_DROME
          Length = 395

 Score =  218 bits (557), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 64/243 (26%), Positives = 101/243 (41%), Gaps = 17/243 (6%)

Query: 7   LYRGKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           L  GK K VY   + P L +L  ++  +A DG    +   K  ++N  N  +   L EAG
Sbjct: 15  LIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLMAHELQGKAAISNTTNGLVFRLLNEAG 74

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-RLGIEEGIELNPPLFDLFLKN 124
           I T       D   + +K  MV +E V R  A GS +K    + EG    PP  +   K+
Sbjct: 75  IRTAYVDQCGDNAFIARKCQMVHIEWVTRRLATGSFIKLNPEVPEGYRFAPPKQETCFKD 134

Query: 125 DAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKL 178
           D+ HDP+  +    +         +  + +  M+  +    +VL++ +      LVD K+
Sbjct: 135 DSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRRTSLVVFEVLERAWKTKNCALVDMKV 194

Query: 179 EFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIEAYEAVA 229
           EFG+   G ++L D    D  R+W       M DK  +          L  +   Y  V 
Sbjct: 195 EFGVDEDGNILLADIIDSDTWRIWPAGDKRLMVDKTVYINLDTVTDSDLNTVKRNYSWVI 254

Query: 230 RRL 232
            +L
Sbjct: 255 EQL 257


>UniRef50_A7H9G3 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=5
           Tax=Myxococcaceae RepID=A7H9G3_ANADF
          Length = 320

 Score =  218 bits (556), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 63/240 (26%), Positives = 100/240 (41%), Gaps = 30/240 (12%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            ELYRGK +  YS    D +V+   +  SA D         KG V ++   F   K+ + 
Sbjct: 24  GELYRGKVRDNYS--RGDRIVMVTTDRVSAFDHVL-GTIPFKGEVLSRLTAFWFEKVKDV 80

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEG 110
             PT +  L   +  +VK+   +P+E V+R    GSL +                G+ + 
Sbjct: 81  A-PTHVVDLPDPSVMVVKRAKPLPIEIVIRGYITGSLWRDYQAGKAGAYGIEWPKGLRKD 139

Query: 111 IELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
              + P+     K +   HD  ++E    + G V+ E       +  +     ++     
Sbjct: 140 QRFDRPIITPSTKAEYGKHDEPISEQELLSQGLVAPELWREATAVAERLFARGQEWALSR 199

Query: 170 GLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQSL 218
           GLILVD K E G+  G++V+ DE  +PD SR W  +  E           +DK+  RQ L
Sbjct: 200 GLILVDTKYEMGVVDGKLVVIDEIHTPDSSRYWVADGYEDRFARGAEQEMLDKENIRQWL 259


>UniRef50_B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=11
           Tax=Bacteroidales RepID=PUR7_AZOPC
          Length = 323

 Score =  218 bits (555), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 58/232 (25%), Positives = 91/232 (39%), Gaps = 21/232 (9%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           Q  LY GK + VY T   D+LV+   +  SA D         KG V N+     +   ++
Sbjct: 14  QTHLYHGKVRDVY-TVGSDMLVIIATDRISAFDVVLSRGIPYKGQVLNQIAAKFLDSTSD 72

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEE 109
             +P            +    +   VE V+R    GS  ++               G++E
Sbjct: 73  I-LPNWKLAEPDPMVTIGLLCEPFKVEMVIRGYLTGSAWRKYKEGERTLCAVTLPEGMKE 131

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +   P+     K    HD  +++        VSKE+  +++  T        ++    
Sbjct: 132 NEKFPNPIITPTTKAYKGHDENISKEEIIERFLVSKEDYEQLEYYTRALFQRGTEIASSK 191

Query: 170 GLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDRFRQSLGG 220
           GLILVD K EFG   G + L DE  +PD SR +  E  +    +RF +  G 
Sbjct: 192 GLILVDTKYEFGKKDGRIYLIDEIHTPDSSRYFYSEDYQ----ERFEKGEGQ 239


>UniRef50_B2KCE9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Elusimicrobium minutum Pei191 RepID=PUR7_ELUMP
          Length = 292

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 63/252 (25%), Positives = 101/252 (40%), Gaps = 42/252 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L +GK + VY  +   +L++   +  S  D     Q   KG +  + + F  +K     
Sbjct: 10  LLKKGKVRDVY--DAGKMLLIVASDRVSVFDCVLPSQIPDKGKILTQISNFWFAKTISI- 66

Query: 66  IPTQME-----------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--- 105
           +P  M                  +  S    LVKK + +  ECVVR    GS  K     
Sbjct: 67  VPNHMISSDINEINIILKLGLDPQYYSGRTVLVKKCERIDFECVVRGYITGSAWKEYQKS 126

Query: 106 ----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELT 155
                     G++E  +   P+F    K D  HD  V+ +Y  +   + K    ++K+ +
Sbjct: 127 GTVCGEKIKEGLKEAQKFPEPIFTPASKADTGHDENVSFAYMLSH--MDKNLAYKIKDTS 184

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK------ 208
            K  +  ++   + G+IL D K EFGL  G+++L DE  +PD SR WD    +       
Sbjct: 185 IKLYNFAEEYLKNCGIILADTKFEFGLIDGDLILIDEILTPDSSRFWDAALYKTGTNPPG 244

Query: 209 MDKDRFRQSLGG 220
            DK   R  +  
Sbjct: 245 FDKQFVRDYMEQ 256


>UniRef50_Q72UH8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Leptospira RepID=PUR7_LEPIC
          Length = 285

 Score =  216 bits (550), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 69/246 (28%), Positives = 100/246 (40%), Gaps = 40/246 (16%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y+GK + +Y     D L+L   +  SA D    +    KG V N+ +        +  +P
Sbjct: 5   YKGKVRDIYDL--GDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKD--VP 60

Query: 68  TQMERL--------------LSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-------- 105
             +                 L     LVKK   +  ECVVR   +GS  K          
Sbjct: 61  NHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAG 120

Query: 106 -----GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
                G +E  +L  P+F   +KND  HD  ++E   E    + KE    +KE +     
Sbjct: 121 IKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEME--NRIGKELFNILKEKSISIFL 178

Query: 161 VLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE------KMDKDR 213
              ++ D AG+IL D K EFG+  G+V+L DE  +PD SR W  +T         +DK  
Sbjct: 179 RASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQI 238

Query: 214 FRQSLG 219
            R  L 
Sbjct: 239 LRNYLE 244


>UniRef50_A1VU36 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=19
           Tax=Bacteria RepID=PUR7_POLNA
          Length = 305

 Score =  216 bits (550), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 66/255 (25%), Positives = 94/255 (36%), Gaps = 43/255 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L RGK +  Y+  N D L++   +  SA D    E    KG +  +   F   KL    
Sbjct: 18  LLARGKVRDNYAVGN-DRLLMVASDRLSAFDVILGEPIPGKGALLTQMALFWFDKLGSIC 76

Query: 66  IPTQM-------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------- 105
            P  +                ++    LVK+L  +PVE VVR   AGS            
Sbjct: 77  -PNHLTGEAPESVVTAAEIPQVAGRSMLVKRLKPIPVEAVVRGYLAGSGWVEYQQSQSVC 135

Query: 106 ------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                 G++   +L  P+F    K +   HD  ++         V  E  A++K L+   
Sbjct: 136 GVPLPAGLKNASKLPEPIFTPAAKAEVGEHDENISYEQVV--KVVGPELAAQIKTLSIAI 193

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDE-FSPDGSRLWDKETLE--------- 207
            +         G+I+ D K EFGL   G + L DE  +PD SR W  E  E         
Sbjct: 194 YETAAAFALTKGIIIADTKFEFGLDENGTLTLMDEVLTPDSSRYWPVEGYEAAFAAGQNP 253

Query: 208 -KMDKDRFRQSLGGL 221
              DK   R  L  +
Sbjct: 254 PSYDKQFVRDWLEAV 268


>UniRef50_B5GT63 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Streptomyces clavuligerus ATCC 27064
           RepID=B5GT63_STRCL
          Length = 345

 Score =  215 bits (549), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 65/252 (25%), Positives = 100/252 (39%), Gaps = 33/252 (13%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L+ GK + +Y  E  D L++   +  SA D     +   KG V  + + +   +LA+  
Sbjct: 18  HLHTGKVRDLYRNEAGD-LIMVASDRISAYDWVLPSEIPDKGRVLTRLSLWWFDRLADL- 75

Query: 66  IPTQMERLL---------SDTECLVKKLDMVPVECVVRNRAAGSLVKRL----------- 105
           +P  +                  + + L MVPVECV R    GS +              
Sbjct: 76  VPHHVVSTDLPDGAPADWEGRTLVCRSLRMVPVECVARGYLTGSGLVEYDESRTVCGITL 135

Query: 106 --GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLK 163
             G+ +G EL  P+F    K  A+ D   N +Y E    V  E  A +++ T       +
Sbjct: 136 PEGLSDGSELPAPIFTPATKA-AVGDHDENVTYEEVARQVGAETAAVLRQTTLAVYGRAR 194

Query: 164 KLFDDAGLILVDFKLEFGLY-KGEVVLGDE-FSPDGSRLWDKETLE------KMDKDRFR 215
            +  D G+IL D K EFG    G +V+ DE  +PD SR W   + +        DK   R
Sbjct: 195 DIARDRGIILADTKFEFGHTEDGTLVIADEVLTPDSSRFWPAASWQPGRPQPSYDKQYVR 254

Query: 216 QSLGGLIEAYEA 227
             L      ++ 
Sbjct: 255 DWLTSPASGWDR 266


>UniRef50_A6GYJ4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=22
           Tax=Bacteroidetes RepID=PUR7_FLAPJ
          Length = 316

 Score =  215 bits (549), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 58/243 (23%), Positives = 98/243 (40%), Gaps = 29/243 (11%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
            Q  +YRGK + VY+  + +LLV+   +  SA D    E    KG + N+     M    
Sbjct: 13  NQKSVYRGKVREVYNIND-ELLVMVATDRLSAFDVVLPEGIPYKGQILNQIATKFMELTQ 71

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIE 108
           +  +P  +         +    +   VE V+R   +G   +                G++
Sbjct: 72  DI-VPNWLIATPDPNVAVGHLCEPFKVEMVIRGYLSGHAAREYALGKRTICGVTMPEGLK 130

Query: 109 EGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
           E  +   P+     K D   HD  ++ S       VS+++   +++ T        ++  
Sbjct: 131 ENDQFPTPIITPTTKADNGSHDEDISRSAILAKNIVSEQDYLVLEKYTRDLYQRGTEIAA 190

Query: 168 DAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFR 215
             GLILVD K EFG    G++VL DE  +PD SR +  E            +++ K+  R
Sbjct: 191 SRGLILVDTKYEFGKTKDGKIVLIDEIHTPDSSRYFYAEGYQDRQNNEEEQKQLSKEFVR 250

Query: 216 QSL 218
           + L
Sbjct: 251 RWL 253


>UniRef50_C6BVA6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=23
           Tax=cellular organisms RepID=PUR7_DESAD
          Length = 299

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 68/254 (26%), Positives = 102/254 (40%), Gaps = 40/254 (15%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           +++   L RGK + +Y  ++ D L+L   +  SA D       D KG + N+   F M  
Sbjct: 10  IKELKLLSRGKVRDIYEVDD-DKLLLVTTDRISAYDVIMPNPIDDKGKILNQITLFWMDM 68

Query: 61  LAEAGIPTQMER---------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL 105
             +  IP  +                  L     LVKK   +P+EC+VR    GS  K  
Sbjct: 69  FKDI-IPNHLIASKVDDYPEVLHKYRDQLEGRSVLVKKAKPLPIECIVRGYITGSGWKDY 127

Query: 106 -------------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARM 151
                        G++E   L  PLF    K +   HD  ++         + KE   ++
Sbjct: 128 QKTGEVCGHKLPEGLKESEMLEQPLFTPSTKAELGEHDENISVEKATEM--LGKELFDKV 185

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE--- 207
           +E T       +    + G+I+ D K EFG+Y GE+++ DE  +PD SR W  E  E   
Sbjct: 186 QEATLSIYKRGRDYAREKGIIIADTKFEFGIYDGELIIIDEVLTPDSSRFWPVEGYEAGK 245

Query: 208 ---KMDKDRFRQSL 218
                DK   R  L
Sbjct: 246 SQPSFDKQFLRDWL 259


>UniRef50_Q313T8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Desulfovibrionaceae RepID=Q313T8_DESDG
          Length = 298

 Score =  215 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 64/255 (25%), Positives = 103/255 (40%), Gaps = 40/255 (15%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           + +   L RGK + +Y  +   LL++   +  SA D    E    KG++ N    F M +
Sbjct: 9   IAEYKLLSRGKVRDIYEVDAETLLIVT-TDRMSAFDVIMGEPIPYKGVILNSITLFWMER 67

Query: 61  LAEAGIPTQMER---------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL 105
            A+  +P  +                 +L     LV+K   +PVEC+VR    GS  K  
Sbjct: 68  FADL-VPNHLIASDVKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITGSGWKDY 126

Query: 106 -------------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARM 151
                        G+ E  +L  PLF    K +   HD  ++         V  +  A++
Sbjct: 127 QKTGMVCGHSLPAGLVESAKLETPLFTPSTKAELGEHDENISVQRAREL--VGDDVAAQI 184

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE--- 207
           + L+ +     ++  +  G+I+ D K EFG+  G V+L DE  +PD SR W  +  +   
Sbjct: 185 ERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGYQPGK 244

Query: 208 ---KMDKDRFRQSLG 219
                DK   R  L 
Sbjct: 245 SQPSFDKQYLRDWLS 259


>UniRef50_Q5X4M9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=33
           Tax=cellular organisms RepID=PUR7_LEGPA
          Length = 312

 Score =  214 bits (546), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 60/249 (24%), Positives = 94/249 (37%), Gaps = 35/249 (14%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y+GK +  Y     D L+L   +  SA D         KG V N  + +         +P
Sbjct: 16  YKGKVRDTYDL--GDQLILVTTDRQSAFDRCL-AAVPYKGQVLNLTSVWWFKNTQSI-VP 71

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------------------GIEE 109
             +  +      + KK  + P+E VVR   +GS    L                  G+ +
Sbjct: 72  NHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRK 131

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +L  P+     K + +HD  ++       GW+++E+         K      ++    
Sbjct: 132 NQKLESPVITPTTK-ETLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQH 190

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQS 217
           GLILVD K EFG   +G +VL DE  +PD SR W               E +DK+  R  
Sbjct: 191 GLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPENIDKEFLRLW 250

Query: 218 LGGLIEAYE 226
                + Y+
Sbjct: 251 FVDHCDPYK 259


>UniRef50_C6CV28 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=4
           Tax=Bacillales RepID=C6CV28_PAESJ
          Length = 299

 Score =  213 bits (542), Expect = 6e-54,   Method: Composition-based stats.
 Identities = 64/250 (25%), Positives = 100/250 (40%), Gaps = 39/250 (15%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K   LY+GK + +Y      L+V+   +  SA D        +KG V N+ + F   + A
Sbjct: 16  KAPLLYKGKVRELYDLGEHYLIVV--TDRISAFDYVLDPAVPQKGNVLNRLSAFWFEQTA 73

Query: 63  EAGIPTQME--------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--- 105
           +      +                LL D   + KK + + +ECVVR    G   ++    
Sbjct: 74  DIQT-NHVVHTDVEKLGDIVTAPELLKDRIMVTKKAERIDIECVVRGYITGGGWRQYQQT 132

Query: 106 ----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELT 155
                     G+ +      P+F    KND  HD  +     +    V  E    +K  +
Sbjct: 133 SAINGIQLPEGMRKNERFPQPIFTPAAKNDVGHDEDIPFERMQEM--VGAELAEELKGRS 190

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETL------EK 208
            K  +   +     G+IL D K EFGL  G+V+L DE  +PD SR W +++       + 
Sbjct: 191 IKLYEFAHEYCAKHGIILADCKFEFGLIDGKVILIDEIFTPDSSRFWGEKSYAYDIEIDS 250

Query: 209 MDKDRFRQSL 218
           MDK+  R  L
Sbjct: 251 MDKEPVRTYL 260


>UniRef50_B5JQ22 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JQ22_9BACT
          Length = 308

 Score =  211 bits (538), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 58/254 (22%), Positives = 100/254 (39%), Gaps = 40/254 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            ++  GK + +Y  ++   ++L   +  SA D         +G++  + ++F   +    
Sbjct: 26  QKIASGKVREIYDLDDS--VLLVATDRISAFDVVLPGGIPGRGLILTQLSHFWFEQTKHI 83

Query: 65  GIPTQMERLLSD--------------TECLVKKLDMVPVECVVRNRAAGSLVKRL----- 105
             P  +     +                  V+KL  + +ECVVR   AGS  +       
Sbjct: 84  A-PNHILPNEQEILAGRLQLSRDSQLRSMAVRKLQPLEIECVVRGYIAGSGWESYQKDRT 142

Query: 106 --------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYK 157
                   G++   +L  P+F    K    HD  V+ S  E    V ++   ++K ++ +
Sbjct: 143 VCGIELPAGLQLASQLPEPIFTPTTKASEGHDMPVSPS--EAAAIVGQDVFDQVKAISLE 200

Query: 158 ANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDKETLE------KM 209
             +   +L   AG+IL D K EFG  + G++ L DE  +PD SR WD             
Sbjct: 201 LYNFGSQLAAKAGIILADTKFEFGTDESGKIYLIDEVLTPDSSRYWDAAEYRVGSSPASY 260

Query: 210 DKDRFRQSLGGLIE 223
           DK   R  L  L +
Sbjct: 261 DKQIIRDYLETLKD 274


>UniRef50_A8LCN0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacteria RepID=A8LCN0_FRASN
          Length = 354

 Score =  210 bits (534), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 61/251 (24%), Positives = 96/251 (38%), Gaps = 41/251 (16%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L  GK + +++  + D ++L   +  SA D     +   KG V    + +   +L + 
Sbjct: 63  THLGSGKVRELFAIGD-DAVLLVASDRISAFDVVLPTEIPDKGAVLTGLSLWWFDQLGDL 121

Query: 65  GIPTQME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
            +P+ +                  L     L ++LDMV +ECV R    GS +K      
Sbjct: 122 -VPSHVISSSVDEYPAELAPYAEQLRGRSMLCRRLDMVQIECVARGYLTGSGLKDYRRSG 180

Query: 106 ---------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELT 155
                    G+E+G  L  P++    K     HD  ++       G V  E  A ++ LT
Sbjct: 181 TVSGHPLPAGLEDGSRLPNPIYTPSTKAPIGEHDENISRDD--AAGRVGAELAAELERLT 238

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDE-FSPDGSRLWDKETLE------ 207
            +       L  + G++L D K EFG    G + L DE  +PD SR W  +         
Sbjct: 239 LQIFGRASDLAAERGILLADTKFEFGHDADGVLRLADEVLTPDSSRFWPADAWTPGGTQP 298

Query: 208 KMDKDRFRQSL 218
             DK   R  L
Sbjct: 299 SYDKQFIRDYL 309


>UniRef50_Q67KF6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Symbiobacterium thermophilum RepID=Q67KF6_SYMTH
          Length = 299

 Score =  208 bits (531), Expect = 9e-53,   Method: Composition-based stats.
 Identities = 74/280 (26%), Positives = 105/280 (37%), Gaps = 55/280 (19%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIM------ 58
             L+RGK + ++   + D L++   +  SA D    +    KG V  + +          
Sbjct: 7   RRLHRGKVREMFEL-DADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHI 65

Query: 59  -------SKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------ 105
                    L   G+P  + RLL     +V++   + VECVVR   AGS  K        
Sbjct: 66  VANHLVSDDLGGLGLPGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTV 125

Query: 106 -------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                  G+     L  P+F   LKND  HD  V E+       +       +KE +   
Sbjct: 126 CGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVPEAEVRRR--LGDAVTDFIKEKSLAL 183

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL------EKMDK 211
                 + + AG+IL D K EFG    E+VL DE F+PD SR W  +        + +DK
Sbjct: 184 YRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDSLDK 243

Query: 212 DRFRQSL---------------GGLIE----AYEAVARRL 232
              R                  G LIE     Y  V  RL
Sbjct: 244 QPVRDWAERTGWNKQPPAPELPGELIEETARRYADVLDRL 283


>UniRef50_Q9UUB4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=59
           Tax=cellular organisms RepID=PUR7_SCHPO
          Length = 299

 Score =  208 bits (531), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 63/251 (25%), Positives = 95/251 (37%), Gaps = 40/251 (15%)

Query: 5   AELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
            ++  GK + +Y   E PD L+    +  SA D         KG V  K + F    L +
Sbjct: 13  TKIATGKVRDLYECVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVL-K 71

Query: 64  AGIPTQME--------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
             + T +                 L D   LVKK  ++P+E +VR    GS  K      
Sbjct: 72  PHVQTHLITSRWEELPPVITKHEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQG 131

Query: 106 ---------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTY 156
                    G++E      PLF    K    HD  ++    E    V  E   ++ E + 
Sbjct: 132 TVHGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPD--EVSKIVGPELAKQVAETSV 189

Query: 157 KANDVLKKLFDDAGLILVDFKLEFGLYK--GEVVLGDE-FSPDGSRLWDKETL------E 207
           K   + + +    G+I+ D K EFG+ +   ++VL DE  +PD SR W           +
Sbjct: 190 KLYKIARDVALKKGIIIADTKFEFGVDETTNKIVLVDEVLTPDSSRFWLASDYTVGKSPD 249

Query: 208 KMDKDRFRQSL 218
             DK   R  L
Sbjct: 250 SFDKQYLRNWL 260


>UniRef50_C9KPE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Mitsuokella multacida DSM 20544 RepID=C9KPE2_9FIRM
          Length = 290

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 65/258 (25%), Positives = 97/258 (37%), Gaps = 43/258 (16%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M++      GK + VY  +  D +++   +  SA D     Q  +KG V  + + F    
Sbjct: 1   MKEYKPFKSGKVREVY--DAGDSIIMVATDRISAFDHILKNQITKKGKVLTQMSKFWFDF 58

Query: 61  LAEAGIPTQMERLLS-------------DTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
             +  IP  M  + +                   KKL M+P+EC+VR    GS       
Sbjct: 59  TKDI-IPNHMISVDNNDMPEFFRQPQFLGNSMKCKKLTMLPMECIVRGYITGSGWASYQE 117

Query: 106 -----------GIEEGIELNPPLFDLFLKND-AMHDPMVNESY-----CETFGWVSKENL 148
                      G++E  +L  P+F    K +   HD  V+         + F     E  
Sbjct: 118 NGTVCGIKLPEGLKESQKLPEPIFTPSTKAELGDHDENVSLEQGAAVFEKEFPGHGMEYA 177

Query: 149 ARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDE-FSPDGSRLWDKETL 206
            ++++ T              G+I+ D K EFGL   G +VLGDE  +PD SR W  E  
Sbjct: 178 EKLRDYTIAIYKKCAAYALSRGIIIADTKFEFGLDEDGNIVLGDEVLTPDSSRFWPLEGY 237

Query: 207 E------KMDKDRFRQSL 218
           E        DK   R  L
Sbjct: 238 EAGKPQPSYDKQFVRDWL 255


>UniRef50_Q11TT6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=13
           Tax=Bacteria RepID=PUR7_CYTH3
          Length = 310

 Score =  208 bits (529), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 58/240 (24%), Positives = 99/240 (41%), Gaps = 28/240 (11%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           Q   Y+GK + VY     D LV+   +  SA D         KG V N+    ++++ A+
Sbjct: 14  QTGFYKGKVRDVYYV--ADKLVVVASDRISAFDVVLPRAIPFKGQVLNQIAAKMLAQTAD 71

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--------------IEE 109
             +P  +  +   +  +  K +   VE V+R   AG   +                 ++E
Sbjct: 72  V-VPNWILSVPDPSVSIGIKCEPFKVEMVIRGYLAGHAAREYKAGKRTLCGVALPEELKE 130

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +L  P+     K D  HD  ++       G VS+ +  ++++ T        +L +  
Sbjct: 131 NDKLPAPIITPTTKADEGHDEDISREDLLARGIVSEADYIQLEKYTQALFQRGTELAEKQ 190

Query: 170 GLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQSL 218
           GLILVD K EFG    ++ L DE  +PD SR +  +            +++ K+  RQ L
Sbjct: 191 GLILVDTKYEFGKVGDKIYLIDEIHTPDSSRYFYIDGYAERQAKGEAQKQLSKEFVRQWL 250


>UniRef50_B0VH32 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Candidatus Cloacamonas acidaminovorans
           RepID=B0VH32_9BACT
          Length = 293

 Score =  206 bits (525), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 60/247 (24%), Positives = 92/247 (37%), Gaps = 40/247 (16%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y       L++   +  SA D         KG + N  + +  +   +  +P 
Sbjct: 16  QGKVRDIYDLGE--TLLIVSTDRISAFDVVFPTLIPDKGKILNAISVYFFNATKDI-VPN 72

Query: 69  QME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG------- 106
                               L +   LVKK  ++P E +VR   +GS  K          
Sbjct: 73  HFITANISEYPVELQPFGEYLEERSMLVKKTRVIPFEFIVRGYLSGSAWKEYKKSNTIGG 132

Query: 107 ------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
                 ++E  +   PLF    K +  HD  ++  Y E    + +     +K+ + +   
Sbjct: 133 MLIAEEMQESQKFPHPLFTPSTKAENGHDENIS--YREFMSRMDESLAVYIKDKSLELYS 190

Query: 161 VLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE------KMDKDR 213
               L    G+IL D K EFG    EV+L DE F+PD SRLW  E  E        DK  
Sbjct: 191 YAHDLLLKKGIILADTKFEFGTIGSEVLLIDELFTPDSSRLWSLEDYEMGKSPKSYDKQF 250

Query: 214 FRQSLGG 220
            R  L  
Sbjct: 251 IRDYLEN 257


>UniRef50_Q8UCE7 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2
           n=32 Tax=Alphaproteobacteria RepID=PUR72_AGRT5
          Length = 316

 Score =  206 bits (524), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 57/256 (22%), Positives = 98/256 (38%), Gaps = 34/256 (13%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           YRGK +  Y   + + +++   +  SA D         KG V  +   +   +  +   P
Sbjct: 16  YRGKVRENYDLPDGNRIII-STDRLSAFDQIL-TCIPYKGQVLTQTARYWFEQTKDIC-P 72

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------------------GIEE 109
             +         + K+LD++PVE VVR   AG+    +                  G+++
Sbjct: 73  NHVVSYPDPNVVIGKRLDILPVEVVVRGYLAGTTGTSILTLYKKGERQMYGMSLPDGMKD 132

Query: 110 GIELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDD 168
              L  P+     K  D  HD  +  S       +++E    +           +++   
Sbjct: 133 NQILPEPVITPTSKAFDGGHDEPLTPSEIVEKKLLTQEQWDTLSRYALALFRHGQEIAAK 192

Query: 169 AGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQ 216
            GLILVD K EFG    G ++L DE  +PD SR W  ++ +            DKD  R 
Sbjct: 193 QGLILVDTKYEFGTDENGTIILADEIHTPDSSRYWMADSYDESFREGKRPASFDKDFVRA 252

Query: 217 SLGGLIEAYEAVARRL 232
            +G   + Y+    ++
Sbjct: 253 WVGERCDPYKDAVPKI 268


>UniRef50_A9A5G9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Thaumarchaeota RepID=PUR7_NITMS
          Length = 274

 Score =  205 bits (523), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 75/229 (32%), Positives = 112/229 (48%), Gaps = 23/229 (10%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           L  GK K +Y  +    L+ +F +  SA D    +   RKG V  KF  F  ++L    +
Sbjct: 4   LTSGKVKDLYDVDES-TLLFKFSDRVSAYDVKFKQDIPRKGEVLCKFAEFWFNEL---DV 59

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-----LGIEEGI------ELNP 115
           P    +  S+ E LVKK+ M+P+ECVVR    GSLV R     + + EG       +L  
Sbjct: 60  PNHFIKRESENEILVKKMKMLPIECVVRGYFYGSLVSRWKKGEVQVPEGTNTTLAAQLPE 119

Query: 116 PLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVD 175
           P+FD   K++  HD  ++++       VS+E    +++ + +    + K+ DD G IL D
Sbjct: 120 PIFDPTTKSE--HDIPIDKNKAIEMNLVSEEQYNWLEKTSIEIYKKMAKITDDVGFILAD 177

Query: 176 FKLEFGLYKGEVVLGDEFSPDGSRLWDKETL------EKMDKDRFRQSL 218
            KLEFG+   ++ LGD   PD  RLW K++       E  DK   R  L
Sbjct: 178 LKLEFGILDDQITLGDSIGPDEYRLWPKDSFEVGKIQEAYDKQLLRDWL 226


>UniRef50_B8IQA8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Proteobacteria RepID=B8IQA8_METNO
          Length = 323

 Score =  204 bits (521), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 56/249 (22%), Positives = 87/249 (34%), Gaps = 34/249 (13%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           RGK +  Y   +    +L   +  SA D         KG V  +   +      +   P 
Sbjct: 27  RGKVRDNYDLPDGRR-ILISSDRISAFDRIL-AAIPFKGQVLTQTARYWFEATRDLC-PN 83

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEEG 110
            +         + ++LD++PVE VVR   AG    S++ +               G+   
Sbjct: 84  HVLDYPDPNVVVARRLDILPVEIVVRGYLAGTTATSILTQYRAGLREMYGHRLPDGMRPN 143

Query: 111 IELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             L   +     K  +  HD  +        G +++E    +           ++L    
Sbjct: 144 ERLPEAILTPTTKAGEGGHDTPLTPDAILAQGLLTQEQWETVSRAALALFARGQELAARR 203

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQS 217
           GLIL D K EFG    G +VL DE  +PD SR W   +           E  DKD  R  
Sbjct: 204 GLILADTKYEFGTDADGRIVLADEIHTPDSSRYWFAASYPERFAAGTAPESFDKDFIRNW 263

Query: 218 LGGLIEAYE 226
           +    + Y 
Sbjct: 264 VVARCDPYR 272


>UniRef50_C0A6D3 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Opitutaceae bacterium TAV2 RepID=C0A6D3_9BACT
          Length = 306

 Score =  204 bits (520), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 57/251 (22%), Positives = 91/251 (36%), Gaps = 42/251 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           ++  GK +  +     D L++   +  SA D    +    KG++  + + +  ++   AG
Sbjct: 25  KIATGKVRENFDL--GDALLIAATDRLSAFDVILPDGIPGKGIILTQISNWWFAQAERAG 82

Query: 66  I--PTQME--------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
           I  P  +               R +     +V+KL  + +EC+VR    GS         
Sbjct: 83  ISLPNHLLPDQAGEFARRGITDRDIQLRSMIVRKLKPLAIECIVRGYLVGSGWSSYQKTG 142

Query: 106 ---------GIEEGIELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELT 155
                    G+ +   L  PLF    K     HD  +N+   +    V      ++K  +
Sbjct: 143 EVCGHRLPAGLRQADRLPAPLFTPTTKAPKGEHDAPIND--AQGAAIVGPALYEQVKAAS 200

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE------ 207
                +       AG+IL D K EFG    G +VL DE  +PD SR W            
Sbjct: 201 LALYSLGHDKAARAGMILADTKFEFGTDAAGNLVLIDEILTPDSSRYWPAGQYAPDQSPP 260

Query: 208 KMDKDRFRQSL 218
             DK   R  L
Sbjct: 261 SYDKQYVRDHL 271


>UniRef50_Q7UJ19 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Rhodopirellula baltica RepID=PUR7_RHOBA
          Length = 320

 Score =  204 bits (519), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 56/262 (21%), Positives = 96/262 (36%), Gaps = 56/262 (21%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL------- 61
           +GK + VY     D L++   +  SA D         KG +    + F   ++       
Sbjct: 24  QGKVRDVYDL--GDRLLIVSSDRISAFDYILPTGIPDKGRLLTAMSRFWFEQMDAGRIGQ 81

Query: 62  -----------AEAGIPTQME--------------RLLSDTECLVKKLDMVPVECVVRNR 96
                          I   +               + L     + +K  +VP ECVVR  
Sbjct: 82  NVGSAGGDGSSNPRSISHHLISTDVPEDVAAVVDPKPLEGRVMVTRKASVVPFECVVRGY 141

Query: 97  AAGSLVKRL-------------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWV 143
             GS  K               G+++  +L+  +F    K +  HD  V+         +
Sbjct: 142 LEGSGWKEYQATGEVCGVSLPAGLKQCDQLSEAIFTPATKAEEGHDENVSYEVMSQS--L 199

Query: 144 SKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWD 202
            +E  ++++ ++        K+  + GL++ D K EFG+  GE++L DE  +PD SR W 
Sbjct: 200 GEEQSSQLRRMSLAIYQDASKIAAERGLLIADTKFEFGVVDGELMLIDEVLTPDSSRFWA 259

Query: 203 KETLE------KMDKDRFRQSL 218
            +  E        DK   R+ L
Sbjct: 260 ADEYEPGHSQRSFDKQFVREYL 281


>UniRef50_Q3Z881 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z881_DEHE1
          Length = 304

 Score =  202 bits (515), Expect = 8e-51,   Method: Composition-based stats.
 Identities = 69/255 (27%), Positives = 99/255 (38%), Gaps = 47/255 (18%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK +  Y     D L++   +  SA D         KG V N+ + F   K A   IP 
Sbjct: 19  KGKVRDTYLL--GDKLLIIASDRISAFDVILPGGIPGKGRVLNRISSFWFEKTARI-IPN 75

Query: 69  QMERLLSDTECLVKKLDM-----VP-----------------VECVVRNRAAGSLVKRL- 105
            +  L+ D  CL K L        P                 VECVVR   AGS      
Sbjct: 76  HVIELVEDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVECVVRGYIAGSAWSEYK 135

Query: 106 ------------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKE 153
                       G+ +  EL  P+F    K +  HD  +  +  E    V KE   ++ E
Sbjct: 136 KTGTVNGMPMPKGLLQSQELPEPIFTPTTKGEGEHDHPMTIAELEAM--VGKELADKLAE 193

Query: 154 LTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL------ 206
            +     + ++     G+I+ D K EFGL   E++L DE  +PD SR WD++T       
Sbjct: 194 KSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSRFWDEKTYRVGEAQ 253

Query: 207 EKMDKDRFRQSLGGL 221
           +  DK   R  L  +
Sbjct: 254 DSYDKQPVRDYLEAI 268


>UniRef50_Q73PW0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Treponema denticola RepID=Q73PW0_TREDE
          Length = 316

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 56/225 (24%), Positives = 93/225 (41%), Gaps = 24/225 (10%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            GK +  YS E    L++   +  SA D         KG V N+ + +      +  I  
Sbjct: 20  TGKVRDWYSPEEGKRLIVT-TDRISAFDRVL-TALPYKGQVLNQLSLWWFENTKDI-IKN 76

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEEG 110
            +         +V ++  +P+E +VR    G    +L  R               G+++ 
Sbjct: 77  HIISCPDPNCIIVTEVKPLPIEVIVRGYITGVTSTALWYRYSLGERNIYGYDFPEGLKKN 136

Query: 111 IELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             L  P+     K     HD  +      + G++SKE    +++      +  +K   +A
Sbjct: 137 QALPKPIITPTTKGGPTGHDERLTCDEVVSQGYLSKEQWDFVQKAALALFERGQKSAKEA 196

Query: 170 GLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLEKMDKD 212
           GLILVD K EFG+ K   ++L DE  +PD SR W  +T E+  K+
Sbjct: 197 GLILVDTKYEFGVDKNNNILLIDEVHTPDSSRYWKLDTYEQRLKE 241


>UniRef50_A7BA15 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Actinomyces odontolyticus ATCC 17982
           RepID=A7BA15_9ACTO
          Length = 333

 Score =  200 bits (510), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 56/293 (19%), Positives = 97/293 (33%), Gaps = 73/293 (24%)

Query: 5   AELYRGKAKTVYSTEN----------------------PDLLVLEFRNDTSAGDGARIEQ 42
             L  GK + +Y+ +                       P+ L++   +  SA D      
Sbjct: 9   TPLSAGKVRDIYAPDEAVVGPAPQTATQAGCPRHAKAGPEALLMVTSDRISAYDYVLPTL 68

Query: 43  FDRKGMVNNKFNYFIMSKLAEAGIPTQMERL-------------------------LSDT 77
              KG V N+   + M +L    +   +  +                         +   
Sbjct: 69  IPGKGAVLNQLAIWWMGQLRPL-VENHLLAVGTKAPAEASRALEGAQPTRFTVPAEVDGR 127

Query: 78  ECLVKKLDMVPVECVVRNRAAGSLVKRL-------------GIEEGIELNPPLFDLFLKN 124
             + + L M+P+ECVVR    GS +                G+ E   L  P+F    K 
Sbjct: 128 AVVCRSLHMIPIECVVRGYLTGSGLAEYRESGSVCGIKLPEGLTEASRLEEPIFTPAAKA 187

Query: 125 D-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           +   HD  +          + +E    +++L+       + +  + G+I+ D K EFG+ 
Sbjct: 188 ELGEHDENITFEQTVER--IGEELAVAIRDLSIALYRAARDIAAERGIIIADTKFEFGID 245

Query: 184 --KGEVVLGDEF-SPDGSRLWDKETLE------KMDKDRFRQSLGGLIEAYEA 227
              G +VL DE  +PD SR W  +           DK   R  L      ++ 
Sbjct: 246 VTTGALVLADEILTPDSSRFWPADQWVEGQVAPSFDKQYLRDWLVSEQSGWDR 298


>UniRef50_D0LZ80 Phosphoribosylaminoimidazolesuccinocarboxamidesy nthase n=1
           Tax=Haliangium ochraceum DSM 14365 RepID=D0LZ80_HALO1
          Length = 331

 Score =  198 bits (505), Expect = 9e-50,   Method: Composition-based stats.
 Identities = 56/244 (22%), Positives = 95/244 (38%), Gaps = 39/244 (15%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           GK +  Y   +   +V+   +  SA D         KG V N+   +   + A+   P  
Sbjct: 32  GKVRDSYVRGDQRTIVV--TDRLSAFDRVL-GTIPYKGQVLNQLAAYWFEETADIA-PNH 87

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEEGI 111
           + R+      +V+++  +  E VVR+   G    S+ +                G+ +  
Sbjct: 88  VVRVPDPNVMVVREVTPLRAEFVVRSYLTGVTSTSIWRAYESGARTFCGHALPEGMHKNQ 147

Query: 112 ELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
            L  P+     K     HD  V+       G +++E+  R  E+  K     ++   + G
Sbjct: 148 PLPEPILTPSTKAPQGEHDISVSREELLASGVITEEHFDRAGEIAMKLFAFGQQRAAERG 207

Query: 171 LILVDFKLEFGLYKG-----EVVLGDEF-SPDGSRLWDKETLE----------KMDKDRF 214
           LIL D K E G+ K      E+++ DE  +PD SR W  E  E           +DK+  
Sbjct: 208 LILADTKYEMGVAKNAAGEDEILVIDEIHTPDSSRYWHAEDFETRVKAGQEPRSLDKEYV 267

Query: 215 RQSL 218
           R+ L
Sbjct: 268 RRWL 271


>UniRef50_UPI000187DCD8 hypothetical protein MPER_11578 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DCD8
          Length = 297

 Score =  198 bits (503), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 56/245 (22%), Positives = 87/245 (35%), Gaps = 34/245 (13%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             + +GK + +YST + D L+    +  SA D         KG +  + + F   KL   
Sbjct: 12  TLVSKGKVRNIYSTSSTDHLLFVATDRISAYDVILKNGIPDKGKLLTQISLFWFKKLGNI 71

Query: 65  GIPTQME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVK--RLGI 107
            IP                     L D   LV+K  ++ +E +VR    G +        
Sbjct: 72  -IPNHFVTADIDEMPEQVRKYKDQLKDRTMLVRKAKVIQIEAIVRGYLTGEIWLGPEYQK 130

Query: 108 EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
           + G  +  PL     ++   HD   +         + +    ++ + + +          
Sbjct: 131 DRGQSMGSPLPTKHGRSKGAHDENFSPEQAV--KLLGQVLYDKVSQASLELYSEAASYAH 188

Query: 168 DAGLILVDFKLEFGLYKG-------EVVLGDE-FSPDGSRLWDKETLE------KMDKDR 213
             GLIL D K EFGL          E++L DE  +PD SR W  E  E        DK  
Sbjct: 189 SRGLILADTKFEFGLIPSTSKPGEEELILVDEVLTPDSSRYWPLEGYEPGKTQPSFDKQY 248

Query: 214 FRQSL 218
            R  L
Sbjct: 249 LRNWL 253


>UniRef50_P27616 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=32
           Tax=cellular organisms RepID=PUR7_YEAST
          Length = 306

 Score =  197 bits (501), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 49/258 (18%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            + RGK + +Y  +    L+    +  SA D         KG++  K + F    L+   
Sbjct: 14  LVARGKVRDIYEVDAG-TLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-ND 71

Query: 66  IPTQMER----------------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVK 103
           +   +                         L D   LV K  ++P+E +VR    GS  K
Sbjct: 72  VRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWK 131

Query: 104 RL-------------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLA 149
                          G++E  E   P+F    K +   HD  ++    +    V  +   
Sbjct: 132 EYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISP--AQAAELVGGDLSR 189

Query: 150 RMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK--GEVVLGDE-FSPDGSRLWDKETL 206
           R+ EL  K     K    + G+I+ D K EFG+ +   E++L DE  +PD SR W+  + 
Sbjct: 190 RVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASY 249

Query: 207 E------KMDKDRFRQSL 218
           +        DK   R  L
Sbjct: 250 KVGESQDSYDKQFLRDWL 267


>UniRef50_P38025 Phosphoribosylaminoimidazole-succinocarboxamide synthase,
           chloroplastic n=17 Tax=cellular organisms
           RepID=PUR7_ARATH
          Length = 411

 Score =  196 bits (498), Expect = 6e-49,   Method: Composition-based stats.
 Identities = 55/231 (23%), Positives = 90/231 (38%), Gaps = 29/231 (12%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y  +  D LVL   +  SA D         KG V N+ + +  +       P 
Sbjct: 111 KGKVRDIY--DAGDYLVLITTDRLSAFDRNLAS-IPFKGQVLNETSLWWFNNTQHIT-PN 166

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGS-----------LVKRL-------GIEEG 110
            +         + KK  + P+E VVR    GS            V+         G+ + 
Sbjct: 167 AIVSSPDRNVVIAKKCSVFPIEFVVRGYVTGSTDTSLWTVYNKGVRNYCGNELSDGLVKN 226

Query: 111 IELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
            +L   +     K  A HD  ++ +     G++++              +  + +    G
Sbjct: 227 QKLPANILTPTTKA-ADHDVPISPNEIVEGGFMTQAEFDEASMKALSLFEFGQGVAKKHG 285

Query: 171 LILVDFKLEFGL-YKGEVVLGDEF-SPDGSRLWDKETLEKMDKDRFRQSLG 219
           LILVD K EFG    G ++L DE  +PD SR W   + E    +RF++ L 
Sbjct: 286 LILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYE----ERFQKGLE 332


>UniRef50_A4SAQ9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ostreococcus lucimarinus CCE9901 RepID=A4SAQ9_OSTLU
          Length = 367

 Score =  195 bits (496), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 54/249 (21%), Positives = 94/249 (37%), Gaps = 35/249 (14%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK +  Y T   D ++    +  SA D         KG V N+ + +   +     +P
Sbjct: 72  YEGKVRDTYVT--GDTMIAVTTDRQSAFDRHL-AYIPFKGAVLNQTSQWWFKQTEHI-VP 127

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------------------GIEE 109
             +         ++++ ++ P+E VVR    GS    L                  G+ +
Sbjct: 128 NAVVATPDPNVTVMRRCEVFPIEFVVRGYLTGSTSTSLWTHYKTGGRNYCGNALDDGMVK 187

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +L   +     K +  HD  ++       GW+ +++L      T +     +++    
Sbjct: 188 NQKLPANIVTPTTK-EKEHDRPISLEDIVKEGWMKQDDLDYCVAKTLEVFAYAQEVAATR 246

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQS 217
           GLILVD K EFG    G + L DE  +PD SR W   +           + +DK+  R  
Sbjct: 247 GLILVDTKYEFGRDADGTIRLIDEINTPDSSRYWLSNSYVERHAAGMEPDMIDKEFLRLW 306

Query: 218 LGGLIEAYE 226
                + Y+
Sbjct: 307 FAERCDPYK 315


>UniRef50_B7FS23 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacillariophyta RepID=B7FS23_PHATR
          Length = 562

 Score =  193 bits (492), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 59/248 (23%), Positives = 95/248 (38%), Gaps = 36/248 (14%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           RGK +  Y       LV    +  S  D   + +   KG V N  + F   + A   IP 
Sbjct: 268 RGKVRDRYPGTKSLALV--TTDRQSGFD-RMLARVPYKGAVLNLTSAFWFEQTAHI-IPN 323

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGS----LVKRL--------------GIEEG 110
            +  +      +VK     P+E VVR+   GS    + +                G+ + 
Sbjct: 324 HLVSVPHPYVSVVKPCQPFPIEFVVRSYMTGSTSTSIWRNYQEGVRSYCGHDLPDGMTKN 383

Query: 111 IELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
            +L   +     K +  HD  ++        W+++ +L        K   + +++    G
Sbjct: 384 QKLECNILTPTTK-EEDHDRPISLVDIVAENWMTQSDLDVCAAAALKVFALGQQVAAAHG 442

Query: 171 LILVDFKLEFGLYK--GEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQS 217
           LILVD K EFG  +  GE++L DE  +PD SR W   T E+          +DK+  R  
Sbjct: 443 LILVDTKYEFGKDEHTGEILLIDEVHTPDSSRYWLASTYEERIAAGEEPDNIDKEFLRLW 502

Query: 218 LGGLIEAY 225
                + Y
Sbjct: 503 FRSQCDPY 510


>UniRef50_B3DVV2 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
           n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DVV2_METI4
          Length = 297

 Score =  193 bits (490), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 67/248 (27%), Positives = 97/248 (39%), Gaps = 33/248 (13%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL--- 61
            ++  GK + +Y  +N   L +   +  SA D    E+   KG+V N+       +    
Sbjct: 13  RKVRSGKVRDLYHWKNE--LWMVTSDRVSAFDCVLAEEIPSKGIVLNQIALGWFERTSVI 70

Query: 62  -------AEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------- 105
                   E  +   +          V   D +PVE + R    G   K           
Sbjct: 71  CPSALLSEELPLEIDLPEW-EGRLMRVLPCDPLPVEFIARGYVVGGAWKEYLEKGTAGGY 129

Query: 106 ----GIEEGIELNPPLFDLFLKNDAMHD-PMVNESYCETFGWVSKENLARMKELTYKAND 160
               G+  G  L  PLF    K    HD P+  ES  E  G    EN   +K LT +   
Sbjct: 130 KLPRGLTYGSPLPEPLFTPTTKAKQGHDLPLDEESAKEIIG----ENYELLKNLTLELYL 185

Query: 161 VLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDRFRQSLG 219
             K    + GLIL+D K EFG+ +G++ L DE  +PD SR W +E  E+ DKDR      
Sbjct: 186 HGKSYAFNKGLILLDTKFEFGIREGKIFLIDELMTPDSSRFWLREDFER-DKDRCPHYDK 244

Query: 220 GLIEAYEA 227
            ++  Y  
Sbjct: 245 QILRHYLE 252


>UniRef50_Q5P7J7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=216
           Tax=cellular organisms RepID=PUR7_AZOSE
          Length = 311

 Score =  190 bits (483), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 59/269 (21%), Positives = 95/269 (35%), Gaps = 49/269 (18%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           ++    L RGK + +Y+  + D L++   +  SA D    +    KG V      F  ++
Sbjct: 10  IKSLPLLGRGKVRDIYAV-DADKLLIVTSDRLSAFDVILPDPIPDKGRVLTAMAAFWFAR 68

Query: 61  LAEAGIPTQM-------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
           L    +P Q+                +     +VK+L  +P+E VVR    GS  K    
Sbjct: 69  LGHI-VPNQLTGIDPESVVASDERDQVRGRSLVVKRLKPLPIEAVVRGYVIGSGWKDYQD 127

Query: 106 -----------GIEEGIELNPPLFDLFLKNDAM-HDPMVNES------YCETFGWV---- 143
                      G+ +  +L  P+F    K D   HD  ++ +        E  G +    
Sbjct: 128 TGAICGIRLPAGLAQAAKLPSPIFTPASKADVGDHDENISFAAAQTRCAAELTGLLAGSG 187

Query: 144 --SKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSR 199
                     ++                G+I+ D K EFG+   G + L DE  +PD SR
Sbjct: 188 TNGARLATEARDAAITLYVEAANYAAGRGIIIADTKFEFGIDSAGTLHLIDEALTPDSSR 247

Query: 200 LWDKETLE------KMDKDRFRQSLGGLI 222
            W  ++          DK   R  L  L 
Sbjct: 248 FWPADSYREGISPPSYDKQYVRDYLETLT 276


>UniRef50_C7NLA9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Kytococcus sedentarius DSM 20547 RepID=C7NLA9_KYTSD
          Length = 336

 Score =  189 bits (482), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 65/282 (23%), Positives = 105/282 (37%), Gaps = 61/282 (21%)

Query: 4   QAELYRGKAKTVYSTE----------NPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKF 53
              ++ GK + +Y+              ++L++   +  SA D       + KG V  + 
Sbjct: 24  YELVHAGKVRELYAPGPDAPLPGGFAADEVLLMVASDRISAYDHVLSTPIEDKGEVLTRM 83

Query: 54  NYFIMSKLAEAGIPTQME--------RLLSDTECLVKKLDMVPVECVVRNRAAG------ 99
           + +   +LA+  +P  +           ++    LVK+L M+PVECV R    G      
Sbjct: 84  SLWWFDQLADL-VPHHVLATEAPLVPEQVAGRAVLVKRLRMLPVECVARAHLTGGGLSEY 142

Query: 100 ------SLVK-RLGIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARM 151
                 S V+ R G+ +G EL  P+F    K  A  HD  ++     T   + +      
Sbjct: 143 RRAGTVSGVRLREGLVDGDELPDPIFTPSTKAPAGEHDEPISYEQVVTT--IGEPLARAA 200

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE-------------------VVLGDE 192
           + LT        ++    G+I+ D K+EFGL   E                   +VL DE
Sbjct: 201 RNLTVAILRRGHEVAAGRGIIVADTKVEFGLEGVEAERDLRTVTQKELDAGSVRIVLADE 260

Query: 193 -FSPDGSRLWDKETLE------KMDKDRFRQSLGGLIEAYEA 227
             +PD SR W  E  E        DK   R  L      ++ 
Sbjct: 261 VLTPDSSRFWPAEGFEAGRQQPSFDKQYVRDWLTSPASGWDK 302


>UniRef50_B3V647 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=uncultured marine crenarchaeote KM3-153-F8
           RepID=B3V647_9ARCH
          Length = 282

 Score =  189 bits (482), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 68/232 (29%), Positives = 102/232 (43%), Gaps = 21/232 (9%)

Query: 4   QAELYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
            + + +GK K  Y S  NPD ++ +F +  SA D         KG     F  F    L 
Sbjct: 8   YSLIKQGKVKAAYESPSNPDTIMFDFSDRISAFDVVIPTDIPEKGKNLRDFAKFFFDNL- 66

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEE---------GIEL 113
              +P  + + +  T+ +VKKLD++PVEC+VR    G L  R+   E           +L
Sbjct: 67  --DVPHHLIKTVGSTKMIVKKLDVIPVECIVRGYLYGGLFDRVNNGEIEIDCDNVLATKL 124

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
           + P+FD   K+D   D  + ES   +   VS+E L  +K  +      +  +   +G ++
Sbjct: 125 SEPIFDPTTKSDIK-DEPITESEIISQKIVSEEELNYLKNTSIDIYKKILDMASKSGFLI 183

Query: 174 VDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETL------EKMDKDRFRQSL 218
            D KLEFG  + G ++L D   PD  RLW           E  DK   R  L
Sbjct: 184 ADLKLEFGKDESGNILLADSIGPDEFRLWSLAKYEVGKIQESYDKQILRDWL 235


>UniRef50_B0U1N3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=21
           Tax=Proteobacteria RepID=PUR7_XYLFM
          Length = 308

 Score =  188 bits (478), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 55/257 (21%), Positives = 91/257 (35%), Gaps = 48/257 (18%)

Query: 10  GKAKTVYS---------TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           GK + V+          T + + L++   +  SA D    +    KG +  + + F   K
Sbjct: 19  GKVRDVFDIPRKRLPVDTRSGEYLLIVATDRLSAFDVVLPDPIPGKGEILCQISNFWFQK 78

Query: 61  LAEAGIPTQMER--------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL- 105
                +P  +                L +    + KKL  V +E + R    GS  K   
Sbjct: 79  TEHL-MPNHLTGINVASVLPDGIDKTLYTQRAVVTKKLKPVGIEAIARGYLIGSGWKDYQ 137

Query: 106 ------------GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMK 152
                       G++E  +L  P+F    K     HD  ++         +  E   R++
Sbjct: 138 RTGKVSGIQLPDGLQEAEKLPDPIFTPSTKAAVGHHDENIDFDTTVKM--IGAELAERVR 195

Query: 153 ELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDE-FSPDGSRLWDKETLE--- 207
           + T +      K   + G++L D K EFG    G + + DE  +PD SR W  +  +   
Sbjct: 196 DATLRIYHFAAKYAAECGILLADTKFEFGTDIDGRLYVMDEMLTPDSSRYWPIDEYQVGT 255

Query: 208 ---KMDKDRFRQSLGGL 221
                DK   R  L  L
Sbjct: 256 SPPSYDKQFVRNYLETL 272


>UniRef50_Q9P9D8 SAICAR synthase n=1 Tax=uncultured marine group II euryarchaeote
           37F11 RepID=Q9P9D8_9EURY
          Length = 301

 Score =  186 bits (474), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 64/248 (25%), Positives = 108/248 (43%), Gaps = 38/248 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY+GK K V+ST++PD+L   F N  S  D        RKG   N+        + + 
Sbjct: 3   EMLYQGKVKQVWSTDDPDILEFRFTNQISVFDQIIPSLIPRKGESLNRTTAHWFKLVEQE 62

Query: 65  GI-PTQMERLLSDTECLVKKLDM---------------VPVECVVRNRAAGSLVKRLG-- 106
           G+  T +  L +   CLV+K+++               VP+E +VR+  +GS  +R    
Sbjct: 63  GVCGTHLVELNAPDRCLVRKVEVVKEPGAIPRDAEWVFVPLEFIVRHYLSGSAWRRFQRG 122

Query: 107 ------------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKEL 154
                        E G++L+ P  ++  K +A  D  ++         ++ +    + + 
Sbjct: 123 ELTAESLGVSQDAEYGVKLSEPFVEVTTKFEAF-DRNIDREEALQISNITDQEFDSIVQA 181

Query: 155 TYKANDVLKKLFDDAGLILVDFKLEFGLYKG-EVVLGDEF-SPDGSRLWDKETLE----- 207
             K ++++++     GLI VD K EF L  G +VVL D F + D  R WD E        
Sbjct: 182 ALKVDEIIEREAAKNGLIHVDGKKEFALGPGRKVVLVDTFGTLDEDRWWDAEAYSNGECI 241

Query: 208 KMDKDRFR 215
           ++ K+  R
Sbjct: 242 ELSKEFVR 249


>UniRef50_C5A6A8 Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase
           (PurC) n=1 Tax=Thermococcus gammatolerans EJ3
           RepID=C5A6A8_THEGJ
          Length = 219

 Score =  183 bits (466), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 60/203 (29%), Positives = 93/203 (45%), Gaps = 9/203 (4%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDG-------ARIEQFDRKGMVNNKFNYFI 57
             +Y GK K VY  E+   LV  F++     DG         I +   KG +  +   F 
Sbjct: 2   RLVYSGKTKDVY--EDGPYLVFHFKDTVLGRDGREDSGGNEVIGEKTGKGSLVLEQTEFF 59

Query: 58  MSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPL 117
              L   G+ T     +   +    + + +P+E + R  A GS ++R            +
Sbjct: 60  FRLLEGNGVKTHFVERIDGRKARFLRAEKIPLEVIYRELAYGSFLRRYKGWAKPFQRLGI 119

Query: 118 FDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFK 177
            +  LK+D++ DP++ E      G  S+E +  MKE T K   +L++ F   GL LVDFK
Sbjct: 120 VEFTLKDDSLDDPLIAEEAIVVLGIASEEEVEVMKEKTRKVAGILREFFSSKGLQLVDFK 179

Query: 178 LEFGLYKGEVVLGDEFSPDGSRL 200
           LEFG   GE+++ DE S D  R+
Sbjct: 180 LEFGRLDGELIVIDELSRDTMRV 202


>UniRef50_B3T553 Putative SAICAR synthetase n=2 Tax=prokaryotic environmental
           samples RepID=B3T553_9ZZZZ
          Length = 314

 Score =  180 bits (458), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 57/254 (22%), Positives = 103/254 (40%), Gaps = 40/254 (15%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M     +Y GK K V+ST++PD++   + +  S  D        RKG   N+ +      
Sbjct: 10  MCMGEMIYHGKVKQVWSTDDPDIIEFRYTDQISVFDQIIPSLVPRKGESLNRTSCHWFEL 69

Query: 61  LAEAGI-PTQMERLLSDTECLVKKLDMV---------------PVECVVRNRAAGSLVKR 104
           + + G+  T +  + +      ++ D++               P+E + R+  AGS  +R
Sbjct: 70  VEKEGVCDTHVIEMNAPDRVRARRFDVIREAGAITPDAENVFVPLEVICRHYLAGSGWRR 129

Query: 105 LG----------------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENL 148
                             + EG++L  P  ++  K +   D ++          +S E  
Sbjct: 130 YARGDVGAEEFGFEPGTVLTEGVKLPKPYLEVSTKFEKF-DRLLGREEALEISNLSDEEF 188

Query: 149 ARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKG-EVVLGDEF-SPDGSRLWDKETL 206
             + E+  K ++++++    +GLI VD K EF L  G   VL D F + D  R WD    
Sbjct: 189 DSILEIVLKVDEIIEREAAKSGLIHVDGKKEFALGVGRRPVLVDSFGTLDEDRWWDAAAY 248

Query: 207 EK-----MDKDRFR 215
           E+     + K+  R
Sbjct: 249 ERGEIVQLSKEFVR 262


>UniRef50_Q9HLC0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=Euryarchaeota RepID=PUR7_THEAC
          Length = 294

 Score =  175 bits (445), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 63/260 (24%), Positives = 112/260 (43%), Gaps = 39/260 (15%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           + +GK K VY  ++ D LV  F N  S  D     + + KG    + + F    + E GI
Sbjct: 4   IAKGKVKDVY--DDGDTLVFRFSNRISVFDKIIPTEIENKGESLCRTSSFWFRYIGERGI 61

Query: 67  PTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRLG-------- 106
                 ++ +    V+K D            ++P+E + R+  AGSL  RL         
Sbjct: 62  KNHFIEMIDNRTMRVRKYDVPEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGSTKPAD 121

Query: 107 ------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
                  + G +L  P+F++  K +   D +++         +++E  A ++E   K ++
Sbjct: 122 IGLNHFPDYGEKLPSPVFEVTTKREKT-DRLLDIDEALEISGLTREEYAEIRETILKIDE 180

Query: 161 VLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE-----KMDKDR 213
           ++++     GLI  D K E  L K  E ++ D F + D  R W+K+  +     ++ K+ 
Sbjct: 181 MMEQEVGKRGLIHADGKKEVALGKEREPIIVDTFGTADEDRFWEKKEYDAGRIVELSKEM 240

Query: 214 FR---QSLGGLIEAYEAVAR 230
            R   +S G     YEA +R
Sbjct: 241 VRQYYRSTGYHDRLYEARSR 260


>UniRef50_B2A872 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=cellular organisms RepID=B2A872_NATTJ
          Length = 226

 Score =  175 bits (444), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 57/209 (27%), Positives = 103/209 (49%), Gaps = 13/209 (6%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSA-------GDGARIEQFDRKGMVNNKFNYFI 57
            ++Y GK K V+  E  + LVL F+++ +        G    + +   KG+ +     + 
Sbjct: 2   KQIYEGKTKKVFLNEKGN-LVLYFKDEVTGTGEDIDPGGNEVVGEIPEKGLSSLAVTKYF 60

Query: 58  MSKLAEAGIPTQME-RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG---IEEGIEL 113
              L E GIPT        +    V++ + + +E + R +A GS ++R       + +E 
Sbjct: 61  FDMLKEKGIPTHFIDASPEEGYMEVQQCEALGLEVICRVKAYGSFLRRYPEFTQNKELEH 120

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
              L ++ +K+D   DP++N+      G ++ E L  MKE+T     +++   +D GL L
Sbjct: 121 LNYLVEVTVKDDERGDPLINDEALIKLGILNNEELDSMKEITKSVAKIIETELNDKGLDL 180

Query: 174 VDFKLEFGLY-KGEVVLGDEFSPDGSRLW 201
           +DFKLEFG    G++++ DE S D  R++
Sbjct: 181 IDFKLEFGRVKDGKIIIIDEISGDSMRVF 209


>UniRef50_C7M1W2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Acidimicrobium ferrooxidans DSM 10331
           RepID=C7M1W2_ACIFD
          Length = 292

 Score =  174 bits (441), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 57/234 (24%), Positives = 90/234 (38%), Gaps = 28/234 (11%)

Query: 10  GKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           GK +  +    +   L++   +  SA D    E    KG +          ++A   + T
Sbjct: 9   GKVRETWVDPRDEAALLVVATDRVSAFDVVLPELVPDKGRLLTAIAAAAFERVAS-DVAT 67

Query: 69  QMERLLSD-------TECLVKKLDMVPVECVVRNRAAGSLVKRLG-------------IE 108
            +  + +D           V++L M+PVECVVR R  GS  +                ++
Sbjct: 68  HLLEVATDVPDVWLGRTLRVRRLAMLPVECVVRGRLVGSAWESYQRDGTAFGRELPRDLD 127

Query: 109 EGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDD 168
            G     PLF    K    HD  +          V +     + + + +   +L   FD 
Sbjct: 128 FGAPFPEPLFTPTTKAHVGHDLPLGPDELGEL--VGERRARELADRSLEVFSLLASWFDA 185

Query: 169 AGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK---MDKDRFRQSL 218
            GL LVD K EFGL    +VL DE  +PD +R+   +  +    +DK   R  L
Sbjct: 186 KGLTLVDAKFEFGLDGRALVLADEIATPDAARIVAGDLGQNPQWLDKQLLRDWL 239


>UniRef50_Q83GX1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Tropheryma whipplei RepID=PUR7_TROWT
          Length = 305

 Score =  172 bits (437), Expect = 8e-42,   Method: Composition-based stats.
 Identities = 49/235 (20%), Positives = 89/235 (37%), Gaps = 31/235 (13%)

Query: 10  GKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA---- 64
           GK + +Y      ++L++   N  SA D     +   KG +  + + +   KL       
Sbjct: 22  GKVRELYVHRQYKNILLMFASNRVSAFDFVLEPEIPEKGRMLTQMSNWWFRKLPAENHLL 81

Query: 65  ---------GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
                     + + +   + +   + +K+D++P E V+R    GS               
Sbjct: 82  ENYDQELYRDLASHIPSHILERSTICRKMDIIPFEFVIRGYLTGSAWADYLENNTVYGIK 141

Query: 106 ---GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
                 +G  L  P+F    K+     P+  E      G    + L  M           
Sbjct: 142 LKGKFRQGDRLPGPIFTPTTKSRTKDTPVRYEDLVNAIGLSHAQQLREMCTDY---YTTA 198

Query: 163 KKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEKMDKDRFRQ 216
           +++  + GLI+ D K EFG+ +G+V L DE  + D +R WD  +  + D    R+
Sbjct: 199 EQIARNKGLIIADAKFEFGIAEGKVYLADELLTADSARYWDINSWGQFDLPIERR 253


>UniRef50_B8J393 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=3
           Tax=Proteobacteria RepID=B8J393_DESDA
          Length = 234

 Score =  172 bits (436), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 64/234 (27%), Positives = 101/234 (43%), Gaps = 23/234 (9%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTS---------AGDGARIEQFDRKGMVNNKFNY 55
             +YRGK K VY     D L L F +  +          G+         +G        
Sbjct: 2   NLVYRGKTKDVYDNGE-DGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMAS 60

Query: 56  FIMSKLAEA-GIPTQMERL-LSDTECLVKKLDMV--PVECVVRNRAAGSLVKRLG----I 107
            I  +LAE  G+ T M    L      V++  M    +E + R    GS ++R G    +
Sbjct: 61  AIFEELAEKNGVSTHMIAYDLPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGV 120

Query: 108 EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
            +G+    P+F++ LK+DA  DP+V  S     G V    +  + +   KA   ++ +F 
Sbjct: 121 YDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDARTMTALLDSNAKAMQAIQAMFA 180

Query: 168 DAGLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKMD----KDRFRQ 216
              L L D K+E+ L  KG  +L DE SP   R +D +T +++      +RFR+
Sbjct: 181 ARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR 234


>UniRef50_UPI000038E095 phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E095
          Length = 296

 Score =  169 bits (429), Expect = 6e-41,   Method: Composition-based stats.
 Identities = 64/259 (24%), Positives = 104/259 (40%), Gaps = 39/259 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L +GK K VY  ++   LV +F +  S  D    +    KG    + + +  + ++  
Sbjct: 4   ELLRKGKVKDVY--DDGKDLVFKFSDRISVFDKIIPDSIPHKGESLCRTSTYWYNIVSSL 61

Query: 65  GIPTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRL------- 105
           GI T    L+SD+E  VKK              MVP+E + R   AGS   R+       
Sbjct: 62  GIDTDFIELVSDSEMKVKKFRQIDRGYKFLSNYMVPLEFITRYYLAGSAYDRVKSGEIDY 121

Query: 106 -------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                      G +L  P F++  K +     +  +   E  G      L  ++E  +K 
Sbjct: 122 HSLGFKNPPVYGEKLPDPFFEVSTKFEKFDRYLHTDEALEISGL-DAGELCEIQETIFKI 180

Query: 159 NDVLKKLFDDAGLILVDFKLEFGL-YKGEVVLGDEF-SPDGSRLWDKETLE-----KMDK 211
           +  +    +  GLI  D K EF L  + + V+ D F + D  R WDK+  E     ++ K
Sbjct: 181 DRRINSSVESRGLIHADGKKEFALGLERKPVIIDTFGTLDEDRFWDKKDYENGQVNELSK 240

Query: 212 DRFR---QSLGGLIEAYEA 227
           +  R   +  G   + Y+A
Sbjct: 241 EMVRQYYRKTGYHQKLYDA 259


>UniRef50_Q94IQ2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Alveolata RepID=Q94IQ2_CRYCO
          Length = 522

 Score =  169 bits (428), Expect = 8e-41,   Method: Composition-based stats.
 Identities = 51/216 (23%), Positives = 86/216 (39%), Gaps = 21/216 (9%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
             GK + +Y       +V+   +  SA D         KG V    + +   +  +  +P
Sbjct: 37  KSGKVRDIYFAGKN--VVMVTNDRVSAFDFILPNLIPFKGQVLCGISEWAFQETKDI-VP 93

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEGIEL 113
             +   +  +  + KK+  + VE +VR    GS+                  G+    + 
Sbjct: 94  NALIENVDSSVVVQKKMTNLNVEFIVRGYLWGSMAAAYEKGDRTFCGLKVPDGLNRFQKF 153

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
           + PLF    K +  HD  +   Y E    + K+   + K++  K      +L    GLIL
Sbjct: 154 DEPLFTPTTKAEVGHDENMT--YAEVEKLIGKDMAKKAKDVAMKLYARGAELMRKRGLIL 211

Query: 174 VDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE 207
           +D K EFGL + G + + DE  +PD SR+   E  E
Sbjct: 212 IDTKYEFGLDEHGVLHVIDEVNTPDSSRMCTVEEWE 247


>UniRef50_C7RD67 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=18
           Tax=Bacteria RepID=C7RD67_ANAPD
          Length = 226

 Score =  167 bits (424), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 58/215 (26%), Positives = 98/215 (45%), Gaps = 15/215 (6%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNN-------KFNYFI 57
            ++Y GK K VY     + L+ +F++D +  DG      +  G+              F 
Sbjct: 2   EKVYTGKTKDVYKLNEEEYLL-KFKDDVTGNDGVFDPGANSVGLTMEGAGHQAVAMTKFF 60

Query: 58  MSKLAEAGIPTQME-RLLSDTECLVKKLDMVP--VECVVRNRAAGSLVKRLG--IEEGIE 112
             KL + G+ T      L   E +VKK ++    VE +VR  A GS ++R G  IE G +
Sbjct: 61  YEKLNDKGLTTHFISADLDKNEAIVKKAEVFGQGVEVIVRYYAVGSFIRRYGKYIESGTK 120

Query: 113 LNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLI 172
           ++ P  ++ LK+D   DP++ +      G +++E    +K+L     +++++      L 
Sbjct: 121 ID-PYVEITLKDDEREDPLITKDALVLLGIMTEEEYEELKDLALNIGEIVREELGKKDLD 179

Query: 173 LVDFKLEFGL-YKGEVVLGDEFSPDGSRLWDKETL 206
           L D K EFG    G+V L DE S    R +  +  
Sbjct: 180 LYDIKFEFGRIEDGKVALIDEISGGNMRAYKGDKY 214


>UniRef50_Q978V1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Thermoplasmatales RepID=PUR7_THEVO
          Length = 294

 Score =  165 bits (419), Expect = 9e-40,   Method: Composition-based stats.
 Identities = 59/257 (22%), Positives = 103/257 (40%), Gaps = 39/257 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L  GK K VY  ++ D LV +F N  S  D     + D KG    + + F    +   
Sbjct: 2   KLLTTGKVKDVY--DDGDTLVFKFSNRISVFDKIIPNEIDNKGESLCRTSAFWFQLIESY 59

Query: 65  GIPTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRLG------ 106
           G+ +    L+ +    V+K              ++P+E + R   AGSL  R+       
Sbjct: 60  GMKSHFIELIDNRTMRVRKFAVPNKVSLGSSNYVIPLEFITRYYVAGSLYDRIKEGKVKP 119

Query: 107 --------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                    E G +L  P+F+   K +   D ++ +      G ++ E+   + E  +K 
Sbjct: 120 MDIGLKHVPEYGEKLIDPIFEATTKREET-DRLLTKKEAMEIGGLTLEDYCEIMEAVFKI 178

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE-----KMDK 211
           +  +       GLI  D K E  L  +  +V+ D F + D  R WD++  +     ++ K
Sbjct: 179 DRRIDMEVSKRGLIHADGKKEIALDRERRIVVVDTFGTADEDRFWDEKEYDNGRVVELSK 238

Query: 212 DRFR---QSLGGLIEAY 225
           +  R   +S+G   + Y
Sbjct: 239 EMVRQYYRSIGYHDKLY 255


>UniRef50_UPI0001926A10 PREDICTED: similar to phosphoribosylaminoimidazole carboxylase,
           phosphoribosylaminoimidazole succinocarboxamide
           synthetase isoform 2 n=1 Tax=Hydra magnipapillata
           RepID=UPI0001926A10
          Length = 391

 Score =  165 bits (419), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 56/251 (22%), Positives = 99/251 (39%), Gaps = 53/251 (21%)

Query: 4   QAELYRGKAKTVYSTE---NPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
              +  GK K +Y+     +   ++++  +  + GDGAR +                   
Sbjct: 9   NDLIIEGKTKAIYALPEYLDGQYVIMKSHDQITCGDGARKDIL----------------- 51

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFD 119
                            EC+V++  M+P+E V R  A GS +KR  G+ EG   + P  +
Sbjct: 52  ----------------IECIVERCQMIPLEIVSRRLATGSYLKRNPGVNEGFRFSTPKME 95

Query: 120 LFLKNDAMHDPMVNESYCETFGW------VSKENLARMKELTYKANDVLKKLFDDAGLIL 173
            F K+DA HDP  +               + +  L  +  +     ++L+K +     +L
Sbjct: 96  YFFKDDANHDPQWSSDQILENKLMIGGLTIGQFELDEITLVAKTCFEILEKAWASRNCVL 155

Query: 174 VDFKLEFGLY--KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIE 223
           VD K+EFG+     E+VL D    D  R+W       M DK  +R        ++  + +
Sbjct: 156 VDMKVEFGVTIKNKEIVLADVIDNDSWRIWPAGDKRLMKDKQVYRNLSVVTTEAMSEIRK 215

Query: 224 AYEAVARRLGV 234
            Y  V+  + +
Sbjct: 216 NYTWVSNEVKL 226


>UniRef50_Q895U7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=cellular organisms RepID=PUR7_CLOTE
          Length = 227

 Score =  164 bits (416), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 58/221 (26%), Positives = 100/221 (45%), Gaps = 17/221 (7%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQ-------FDRKGMVNNKFNYFIMS 59
           +Y+GK K V+  E+ + L+ +F++D +  +G             +  G    +       
Sbjct: 4   VYKGKTKDVFLLEDGNYLL-KFKDDVTGENGVFDPGANSVGLTMEGAGRAALRLTKLFFE 62

Query: 60  KLAEAGIPTQMERL-LSDTECLVKKLDMVP--VECVVRNRAAGSLVKRLGI--EEGIELN 114
           +L E  IPT      + +    VK   +    +E + R RA GS ++R G+  +EG  L+
Sbjct: 63  RLKEEKIPTHYIDSNVEEGTMKVKPAKIFGNGLEVICRYRAVGSFMRRYGMYAKEGQVLD 122

Query: 115 PPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILV 174
               ++ LK+D   DP + +   +  G +S      +K+LT K + ++K      G+ L 
Sbjct: 123 A-FVEVTLKDDERQDPPITKDALDMLGILSLREYDILKDLTKKISGIVKDELSKKGIELY 181

Query: 175 DFKLEFGL--YKGEVVLGDEFSPDGSRLW-DKETLEKMDKD 212
           D KLEFG       + L DE S    R + D E +E +D +
Sbjct: 182 DIKLEFGRIDEDNHIALIDEISGGNMRAYKDGEYIEPLDLE 222


>UniRef50_Q466M0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Archaea RepID=Q466M0_METBF
          Length = 296

 Score =  156 bits (395), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 68/288 (23%), Positives = 106/288 (36%), Gaps = 65/288 (22%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           + +GK K +      + + LE RN  + GD AR E     G+        I S L   G+
Sbjct: 3   ISQGKTKVILPGPRKNTVFLETRNVLTGGDAARRETIAGIGIHKTTQAANIFSLLNRKGL 62

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR---LGIEEG--IELNPPLFDLF 121
           PT      S    L  + +M+P+E VVR  A GS ++R    G +EG     + P++++F
Sbjct: 63  PTAFIERTSPNTLLCYQCEMLPLELVVRRYAWGSYLQRHPEYGNQEGTAYRFDEPVWEIF 122

Query: 122 LKNDAMHDPM------VNESYCETF----------------------GWV---------- 143
            K   +  P+      ++E                             W+          
Sbjct: 123 HKLSVVGFPVTDKPYQIDEEAAREQFLHNGIWQEGVYTDPYIQVDKNQWLLYPSKKELSK 182

Query: 144 -----------SKENLARMKELT-----YKANDVLKKLFDDAG-LILVDFKLEFG--LYK 184
                      S+E L  + +           D  +K+    G + LVD K+E G  L  
Sbjct: 183 SKPILSMKPACSQEELDYIVQAIMLPTFLALEDAWRKIMTTYGPMELVDLKIEVGRRLDN 242

Query: 185 GEVVLGDEFSPDGSRLWDKETLEK-MDKDRFR--QSLGGLIEAYEAVA 229
             +V+ D    D  R+W     EK +DK  FR    L  + E Y  +A
Sbjct: 243 NRIVIADVIDNDSWRIWSGGNPEKQLDKQCFRDGNPLDQVAENYATLA 290


>UniRef50_B5GV74 Saicar synthetase n=1 Tax=Streptomyces clavuligerus ATCC 27064
           RepID=B5GV74_STRCL
          Length = 238

 Score =  153 bits (387), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 59/230 (25%), Positives = 95/230 (41%), Gaps = 14/230 (6%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            G++K ++      L V+E      +   +R E  +  G +  +F     ++LA+ G+ T
Sbjct: 18  EGRSKRIWLLS-GGLCVVEMIPSLRSFTYSRDELVEETGPLRLEFYDRAAARLAKGGVRT 76

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--IEEGIELNPPLFDLFLKNDA 126
              R L+ T  L +  +  P E VV+NRA GS + +         EL  P+     + D 
Sbjct: 77  GFVRRLAPTVYLSEFHEAPPFEVVVKNRAVGSTLVKYPGLFPANSELPKPVVKFDYRIDP 136

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KG 185
              P + E Y           +   + +    ND L        L + DF +  GL  +G
Sbjct: 137 EDQP-IGEDYLRALDLP----VEEFRRIALAVNDTLISWLAP--LEVWDFCIILGLDPQG 189

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGG--LIEAYEAVARRLG 233
           E VL  E SPD  RL   +    +DKD FR       L+ A++ +   +G
Sbjct: 190 EPVLISEVSPDCMRLRHPDG-SSLDKDLFRHGASSEELVTAWQRLLDEIG 238


>UniRef50_Q6NRP1 LOC431975 protein (Fragment) n=2 Tax=Xenopus RepID=Q6NRP1_XENLA
          Length = 371

 Score =  148 bits (375), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 44/218 (20%), Positives = 90/218 (41%), Gaps = 14/218 (6%)

Query: 1   MQKQAELYRGKAKTVYST-ENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           ++   +L   +A  VY   E P  ++++ ++  +A   A     D K  V+NK    +  
Sbjct: 82  LKLGKKLREDEATEVYELSEQPGCVLIQSKDHINAQYTAWDGHKDTKASVSNKATSRVFI 141

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L EAGI T   +  S+   +  + +M+P+E   R    G   +    +EG   + P  +
Sbjct: 142 LLQEAGIKTAFVKRCSEAAFIATQCEMIPIEWFCRKIPTG---RNTETDEGYRFSQPKVE 198

Query: 120 LFLKNDAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
           ++  +D  +   +++              + K  +  M   T    ++++K +      L
Sbjct: 199 MYKVDDTSN-HQLSKEQLMAVKLICAGLLIGKMEVDVMTRSTIAIFEIIEKAWRAQDCTL 257

Query: 174 VDFKLEFGLY--KGEVVLGDEFSPDGSRLWDKETLEKM 209
           VD +++FG+   K E++L D        LW      ++
Sbjct: 258 VDMRIKFGVDVTKKEILLTD-IKCGSQALWPLGNKSQL 294


>UniRef50_A8M140 SAICAR synthetase n=1 Tax=Salinispora arenicola CNS-205
           RepID=A8M140_SALAI
          Length = 236

 Score =  146 bits (369), Expect = 6e-34,   Method: Composition-based stats.
 Identities = 63/225 (28%), Positives = 91/225 (40%), Gaps = 14/225 (6%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            G++K V+  E P   V+E      +    R E  D    +   F  ++   LA+AG+PT
Sbjct: 14  TGRSKKVWFVE-PGRCVVEMIPSLRSFTHDRDELMDGTAELRLDFFEYVSGVLAKAGVPT 72

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--IEEGIELNPPLFDLFLKNDA 126
                L     L      VP E +V+NRA GS  ++     EEG    PP+     + D 
Sbjct: 73  VFRERLGPITYLADYRPAVPFEVIVKNRATGSTTRKYPGLFEEGRVFAPPVVKFDYRTDP 132

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE 186
              P + E Y    G     ++   + L    N VL  L     L L DF L     +  
Sbjct: 133 EDQP-IGEDYLRRTGV----DVEAYRRLALACNTVLHTLVSP--LELWDFCLVIAPDEER 185

Query: 187 -VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSL--GGLIEAYEAV 228
            +V+  E SPD  RL   +  E  DKD FR+      +IE +  +
Sbjct: 186 GLVINSEISPDCMRLRRADG-EPYDKDLFRRGASREQIIERWTEL 229


>UniRef50_Q7MLF9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=112
           Tax=cellular organisms RepID=PUR7_VIBVY
          Length = 367

 Score =  133 bits (336), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 53/280 (18%), Positives = 95/280 (33%), Gaps = 60/280 (21%)

Query: 1   MQKQAELYRGKAKTVYSTENPD-----------------LLVLEFRNDTSAGDGARIEQ- 42
           ++    ++ GK ++VY     D                 L ++   +  SA D     + 
Sbjct: 16  IRTDKPVHSGKVRSVYWLTEEDSARLIKEKGYNVAPDAPLAIMVISDRISAFDCIWHGEH 75

Query: 43  ----FDRKGMVNNKFNYFIMSKLAEAGI-PTQMERLLSDTECLVKKLDMVPVECVVRNRA 97
                  KG   N  +        E G+  + +  +      +V+K   V +E + R   
Sbjct: 76  GLNGVPGKGAALNAISNHWFGLFKENGLADSHILDIPHPFVWIVQKAKPVKIEAICRKYI 135

Query: 98  AGSLVKRL--------------GIEEGIELNPPLFDLFLKN--------DAMHDPMVNES 135
            GS+ +                G+E+   L   L     K             D  +   
Sbjct: 136 TGSMWRAYEKGEREFCGIQLPEGLEKDKALPDLLMTPSTKGILKGIPGVPEADDVNITRQ 195

Query: 136 YC----ETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKG-----E 186
                   F + S +++A  ++L      V+ +   + G I VD K EFG         +
Sbjct: 196 NIADNFAAFNFSSADDIALYEKLLKDGFGVISEALANVGQIFVDTKFEFGYVTDAAGNEK 255

Query: 187 VVLGDEF-SPDGSRLWDKETLE-----KMDKDRFRQSLGG 220
           ++  DE  +PD SR+WD +  +     +  K+ FRQ L  
Sbjct: 256 LIYMDEVGTPDSSRIWDAQEYQAGKIVENSKEGFRQFLLN 295


>UniRef50_A4NXH0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Haemophilus influenzae RepID=A4NXH0_HAEIN
          Length = 210

 Score =  128 bits (323), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 42/197 (21%), Positives = 78/197 (39%), Gaps = 31/197 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            ++Y GK + +Y  ++   +++   +  SA D    +   RKG +  + + F  +KLA  
Sbjct: 11  KKIYSGKVRDLYEIDDK-RMLMVASDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHI 69

Query: 65  GIPTQME-------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------ 105
            +P                  L+ D   + K+L  + +E +VR    GS +K        
Sbjct: 70  -MPNHFTGESVYDVLPKEEADLIKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYKQTGTI 128

Query: 106 -------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYK 157
                  G+ E  +L   +F    K +   HD  +N SY E    +  +  A++K+    
Sbjct: 129 CGLKLPEGLVEASKLPEAIFTPSSKEEVGNHD--INISYAECEKLIGSDLAAQVKKKLSH 186

Query: 158 ANDVLKKLFDDAGLILV 174
               L+ +    GL+ V
Sbjct: 187 FIPWLQNMHSLKGLLFV 203


>UniRef50_Q6MIY7 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Bdellovibrio bacteriovorus RepID=Q6MIY7_BDEBA
          Length = 344

 Score =  116 bits (290), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 60/259 (23%), Positives = 94/259 (36%), Gaps = 54/259 (20%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
             +YRG  K +Y  +N D +V E+ N  S  D G   ++   KG             L+ 
Sbjct: 2   NLIYRGSVKDLY--QNNDKIVFEYSNRYSIFDWGEMPDEIPHKGEALAAMASMFFEHLSA 59

Query: 64  AGIPTQMERLLSDTECLVKKLDMV-----------------------PVECVVR------ 94
            G  +      S T   V+ + ++                       P+E + R      
Sbjct: 60  RGFSSHYLSGRSRTSIEVQPVKVLRPEWKGEAYDYSMYASRPTQCLVPLEVIFRRHLGQG 119

Query: 95  NRAAGSLVKRLGIEEGIELN----------PPLFDLFLKNDAMHDPMVNESYCETFGWVS 144
           N   G L K       +EL+          P L ++  K +   D  ++++       V+
Sbjct: 120 NSLEGRLKKNPAYLADLELSKMPTSADSFMPALVEVSTKLETT-DRYLSKADVAAMNVVN 178

Query: 145 KENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY---KGE--VVLGDEFSPDGSR 199
               A +++ T      L+KLF   G+ L D KLEF       G+  +VL D   PD  R
Sbjct: 179 DAEYAALRKNTQDVAAELEKLFASFGVKLWDGKLEFAFTHENNGQRGLVLVDSIGPDELR 238

Query: 200 LWDKETLE--KMDKDRFRQ 216
           L    T E   + K+  RQ
Sbjct: 239 L----TYEGLPLSKEFLRQ 253


>UniRef50_D2RHF2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Archaeoglobaceae RepID=D2RHF2_ARCPR
          Length = 335

 Score =  114 bits (285), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 58/279 (20%), Positives = 97/279 (34%), Gaps = 66/279 (23%)

Query: 10  GKAKTVYSTENP-----DLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
           G  K +   E P           F +  S  D G   +  + KG      + +   KL +
Sbjct: 2   GSVKDLIVIEEPKEDKMGFADFVFSDRYSVFDYGVMPDLIEHKGESLCLISAYFFEKLED 61

Query: 64  AGIPTQMERLLSD-------------TECLVKKLDM----------------------VP 88
            GI T    L+ +                 VK   +                      +P
Sbjct: 62  YGIKTHYIGLVENGKVKRFDEISKPTNVMRVKLARVVKPEKKNGYDYSVFRKLKGNFLIP 121

Query: 89  VECVVRN-RAAGSLVKR-----------LGIE---EGIELNPPLFDLFLKNDAMHDPMVN 133
           +E + RN    GS + R            G++   EG++L  P+ D   K + +   + +
Sbjct: 122 LEVIYRNSIPKGSSLLRRIKEGKVKPEDFGLKEIVEGMKLEKPIIDFSTKLEDVDRYLSH 181

Query: 134 ESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE 192
               E  G  S E   R+KE+  K ++++       GL   D K+EF L +   +++ D 
Sbjct: 182 GEAKEISGL-SDEEFERLKEIALKVDEIITSEVSKVGLENEDGKIEFALDEFRNIIVVDA 240

Query: 193 F-SPDGSRLWDKETLEKMD--KDRFRQSLGGLIEAYEAV 228
             +PD  R     + E  D  K+  R+      E YE +
Sbjct: 241 VGTPDECRF----SYEGFDVSKELLREYYRK-TEWYERL 274


>UniRef50_B3G3Y1 Saicars n=1 Tax=Adineta vaga RepID=B3G3Y1_ADIVA
          Length = 531

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 51/256 (19%), Positives = 90/256 (35%), Gaps = 71/256 (27%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDR------------------ 45
             +L+ GK KT+YS  +   L+   R D     G+ +                       
Sbjct: 11  HQKLFDGKTKTIYSIIDQPSLICIHRKDHHDSSGSILS-IPGSRRSSVDSTIRLNNQQHN 69

Query: 46  --------KGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEC-LVKKLDMVPVECVVRNR 96
                   KGM+           L EA IPT      +  +  + KK  M+P+  ++R  
Sbjct: 70  RNHTDILSKGMLTTSITTCAYEILREASIPTFYVAPYNQPDMFIAKKCTMIPILWIIRRL 129

Query: 97  AAGSLVKR-LGIEEGIELNPPLFDLFLK---------------------------NDAMH 128
           A  + VKR  GI  G    PP+ ++F K                           +D   
Sbjct: 130 ANETCVKRNPGIINGHRFIPPMIEIFYKRHPFLYKQSTIDIGDDNLEYDRESQFDDDESD 189

Query: 129 -DPMVNE---------SYCETFGW-VSKENLARMKELTYKANDVLKKLFD-DAGLILVDF 176
            D  ++          ++  T    +S +++  M E+     D+L+ ++       L+D 
Sbjct: 190 LDECISSIWSYEQLLNTHINTENLKISHKDIEYMYEICCTIFDILEHVWMVKKNCQLIDL 249

Query: 177 KLEFGLY---KGEVVL 189
           K+EFG+      E+++
Sbjct: 250 KIEFGITTTSPKEIIV 265


>UniRef50_B2L3N2 Phosphoribosylaminoimidazole carboxylase n=3 Tax=Bdelloidea
           RepID=B2L3N2_9BILA
          Length = 572

 Score =  110 bits (276), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 47/262 (17%), Positives = 86/262 (32%), Gaps = 76/262 (29%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRND--------------------------------T 32
            +L+ G+ KT+YS  +   L+  FR D                                 
Sbjct: 11  QKLFDGRTKTIYSMIDQPGLICIFRKDFYQPAGSTLSIPGSRRSSIDSSIFFLQQQQQQK 70

Query: 33  SAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEC-LVKKLDMVPVEC 91
              +G    +   KG++       +   L EA IPT            + +K  M+P+  
Sbjct: 71  QNNNGTTNMEIPGKGVLITSITTCVYEILREASIPTFYVAPHPQPAMFIARKCTMIPILW 130

Query: 92  VVRNRAAGSLVKRLG-IEEGIELNPPLFDLFLKNDAM----------------------- 127
           +VR  A  + +KR   +  G    PP+ +++ K   +                       
Sbjct: 131 IVRRLATETYIKRNPSVVNGHRFVPPIVEIYHKRHPLIYRRLTLSSLDENVVSSHESLLD 190

Query: 128 ---------------HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD-DAGL 171
                          +D ++N  +      +++  +  M E      D+L+ ++      
Sbjct: 191 DDDSDVDECLSSIWSYDQLLNAQFDIEDLKITQTEIEYMYETCCTIFDILEHIWMVKKNC 250

Query: 172 ILVDFKLEFGL---YKGEVVLG 190
            L+D KLEFG+      E+VL 
Sbjct: 251 QLIDLKLEFGITTTTTKEIVLA 272


>UniRef50_O28996 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
           n=1 Tax=Archaeoglobus fulgidus RepID=PUR7_ARCFU
          Length = 331

 Score =  107 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 61/263 (23%), Positives = 100/263 (38%), Gaps = 57/263 (21%)

Query: 10  GKAKTVY----STENPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEA 64
           G  K +       E P L    F N  S  D G   ++ + KG        +   KL EA
Sbjct: 2   GSVKDLVVLKEPAEKPGLGRFIFSNRYSVFDYGEMPDKIEDKGRALCMVTAYFFEKLEEA 61

Query: 65  GIPTQMERLLSD-------------TECLVKKLDMV-------------------PVECV 92
           GI T    L+                E  VK + ++                   P+E +
Sbjct: 62  GIATHYLGLVEGGKVRRFDEVENAVNEMEVKLVRVIKPKNGDYSIFKTLKGNFLVPLEII 121

Query: 93  VRN-RAAG-SLVKRL-------------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYC 137
            RN    G SL++R+              IE G+ L  P+ D   K + +   + +    
Sbjct: 122 YRNSIPEGSSLLRRIERGEAKPEDFGLTKIEAGMRLERPIVDFSTKLEDVDRYLSHSEAK 181

Query: 138 ETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SP 195
           E  G  S E    +KEL  K ++++ +    AGLI  D K+E  L     +++ D   +P
Sbjct: 182 EISGL-SDEEFEALKELVVKVDEIITREVSKAGLINEDGKIEVALDDERNLMVVDAVGTP 240

Query: 196 DGSRL-WDK-ETLEKMDKDRFRQ 216
           D  R  +D  E  +++ ++ +R+
Sbjct: 241 DECRFSFDGFEVSKELLREYYRK 263


>UniRef50_UPI00015FF598 UPI00015FF598 related cluster n=1 Tax=Drosophila melanogaster
           RepID=UPI00015FF598
          Length = 183

 Score =  107 bits (269), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 31/95 (32%), Positives = 46/95 (48%), Gaps = 1/95 (1%)

Query: 7   LYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +  GK K VY   E P L +L  ++  +AGDG +      K  ++N  N  ++  L EAG
Sbjct: 11  IIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVVRLLNEAG 70

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGS 100
           I T   +       + +K  M+P+E V R  A GS
Sbjct: 71  IRTAYVKQCGAKSFIARKCQMIPIEWVTRRLATGS 105


>UniRef50_A8M136 SAICAR synthetase n=1 Tax=Salinispora arenicola CNS-205
           RepID=A8M136_SALAI
          Length = 322

 Score =  106 bits (266), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 48/256 (18%), Positives = 91/256 (35%), Gaps = 45/256 (17%)

Query: 12  AKTVYSTE-----NPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            K ++  E          VL F +  S  D G   +    KG                AG
Sbjct: 6   TKDLHVLEPATGGRAGDAVLTFTDRYSVFDHGVMPDLIPGKGRATCAMAVLSFGLFERAG 65

Query: 66  IPTQMERLLSDTECLVK-------------KLDMVPVECVVRN--RAAGSLVKRLGI--- 107
           I T     +++    ++                ++P++ V R   R   S+ +R+     
Sbjct: 66  ITTHFVEQVAEDAIRIRLLGLDLTGSRRTGPAQLIPLQIVYRRQLRPESSVHRRVATGAV 125

Query: 108 ---------EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                     E   L+P + +   K +   D  ++ +     G +S  +L  + E   + 
Sbjct: 126 DPASIPPMEPETGRLDPVMVEFTSKFEET-DRFLDPAAATRVGHISPADLTGLTEQARRV 184

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDKETLEKMDKDRFRQ 216
              + +     GL LVD K E+G  + G+++L D   +PD +R + ++T   + K+  R 
Sbjct: 185 CAAVDEHCVRVGLTLVDGKTEYGFDEHGDLMLVDHAGTPDENRFYFEDT--PVCKELLR- 241

Query: 217 SLGGLIEAYEAVARRL 232
                   Y  +  R+
Sbjct: 242 ------ALYPELRERV 251


>UniRef50_A8EWL2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Arcobacter butzleri RM4018 RepID=A8EWL2_ARCB4
          Length = 317

 Score =  106 bits (265), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 61/266 (22%), Positives = 92/266 (34%), Gaps = 48/266 (18%)

Query: 4   QAELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
               Y GK   +YS       ++L   +  S  D     + + KG+     + F      
Sbjct: 32  YNLFYIGKNADLYSCPGEEPKVLLVRSDRCSVFDIPLNLEINGKGVSQTAISNFGADFAK 91

Query: 63  EAGIPTQMER-------LLSDTECLVKKLDMV---------PVECVVRNRAAGSLV---- 102
           +AGI T +          ++    +++    +           E + RN   GSL     
Sbjct: 92  KAGIRTAILSENVDSSLSIAPRCQMMELCKPLEAQIDGEVVQFELIFRNYLTGSLFEATQ 151

Query: 103 ---KRLG------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKE 153
                 G      ++E  +   PLF    K   + D  +N            E    +  
Sbjct: 152 KGQDPYGLNLSSDLKEWSKFETPLFTPTTK--GVKDIPLNSQKVR-------ETFPEIVS 202

Query: 154 LTYKANDVLKKLFDDAGLILVDFKLE-FGLYKGEVVLGDE-FSPDGSRL-----WDKETL 206
              K      K   D G+I+VD KLE F   KGE VLGDE  +P+ SR      +D    
Sbjct: 203 SLEKLFKDFTKFAQDNGIIVVDTKLEVFVNSKGEWVLGDEVLTPESSRFISKEDFDAGNY 262

Query: 207 EKMDKDRFRQSLGGLIEAYEAVARRL 232
             MDK   R   G   E ++  A+ L
Sbjct: 263 ISMDKQILR-DFGK-SENWKEKAKDL 286


>UniRef50_Q5IWX2 Plastid phosphoribosylaminoimidazole-succinocarboxamide synthase
           (Fragment) n=1 Tax=Prototheca wickerhamii
           RepID=Q5IWX2_PROWI
          Length = 245

 Score =  105 bits (263), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 31/145 (21%), Positives = 50/145 (34%), Gaps = 23/145 (15%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK +  Y     D L++   +  SA D         KG + N+ + + M       +P
Sbjct: 106 YVGKVRDTYDL--GDKLLIVTTDRQSAFDRHLAS-IPFKGQILNQTSAWWMEATRSI-VP 161

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGS-----------LVKRL-------GIEE 109
             +  L      L+ K  + PVE V R    GS             +R        G+ +
Sbjct: 162 NALLGLPDPNASLMTKCTVFPVEFVCRGYMTGSTDTSLWTHYAAGERRYCGNDFPDGMVK 221

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNE 134
              L   +     K+ A HD  ++ 
Sbjct: 222 NARLPVNVITPTTKS-AEHDVPISP 245


>UniRef50_D1JGB5 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
           n=2 Tax=uncultured archaeon RepID=D1JGB5_9ARCH
          Length = 346

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 54/251 (21%), Positives = 89/251 (35%), Gaps = 61/251 (24%)

Query: 10  GKAKTVY-----STENPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
           G  K +      S   P      F +  S  D G   +    KG        +   KL E
Sbjct: 2   GSVKDLLVIAQPSKNKPGTAQFVFSDRYSVFDWGEMPDLIQDKGAAICITTAYFFEKLEE 61

Query: 64  AGIPTQMERLLSDTEC----------------LVKKLDM--------------------V 87
            GIPT    L+ + +                 L++ L                      +
Sbjct: 62  MGIPTHYRGLVEEDKIKRLAALNSPQSRMELNLLRVLKPRIIGDTYDYSIYKEERTNILI 121

Query: 88  PVECVVRN-----------RAAGSL-VKRLGIEE----GIELNPPLFDLFLKNDAMHDPM 131
           P+E + RN             AGSL ++ +G+++    G  L  P+ D+  K +A  D  
Sbjct: 122 PLEIIYRNSLPEGSSVFRRLKAGSLSLEDIGLDKMPYPGQVLERPVLDVSTKLEAS-DRY 180

Query: 132 VNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLG 190
           +N +  +    +S+  L  +   T + N+++ +    AGL   D KLEFG  +   + L 
Sbjct: 181 INWNDAKELAGLSEAELEEITSATLRINELITREARMAGLTNEDGKLEFGFDEARNLTLV 240

Query: 191 DEF-SPDGSRL 200
           D   + D  R 
Sbjct: 241 DTLGTLDECRF 251


>UniRef50_Q3IMR8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=3
           Tax=Halobacteriaceae RepID=Q3IMR8_NATPD
          Length = 339

 Score =  103 bits (257), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 43/243 (17%), Positives = 82/243 (33%), Gaps = 57/243 (23%)

Query: 26  LEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLS--------- 75
             F +D S  D G   +    KG            +L   GIPT    ++S         
Sbjct: 23  FVFTDDYSVFDWGKMPDSIPNKGASLCAMGAANFERLEAEGIPTHYRGVVSGGEVVALSE 82

Query: 76  ----DTECLVKKLDM------------------------VPVECVVRN-RAAGSLVKR-- 104
                 E  ++   +                        +P+E V RN    GS ++   
Sbjct: 83  AVSPPREMAIELTQVPDLPHDGREYDYEAFHADAGENYLIPLEIVFRNTVPVGSSLRSRA 142

Query: 105 ----LGIE------EGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKEL 154
                G++      E ++L  P+ +   K +     +   S         K ++  ++ +
Sbjct: 143 DPEAFGLDYEEWPDEPVDLPEPVVEFSTKFEESDRYL---SRSNADYIAGKADIDDLESV 199

Query: 155 TYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDR 213
               N ++ +   +AGL   D K+E   + GE+ + D   + D +R       +++ K+ 
Sbjct: 200 ARDVNTIVTETAAEAGLKHEDGKIECLYFDGEIRVADVVGTFDENRF--SHDGQQLSKEV 257

Query: 214 FRQ 216
            RQ
Sbjct: 258 VRQ 260


>UniRef50_D0NC79 Phosphoribosylaminoimidazole-succinocarboxamide synthase, putative
           n=1 Tax=Phytophthora infestans T30-4 RepID=D0NC79_PHYIN
          Length = 143

 Score = 96.8 bits (240), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 38/104 (36%), Gaps = 4/104 (3%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            GK + VY  E  D ++L   +  SA D A       K  V    + +  ++     +  
Sbjct: 44  TGKVRDVYVFE--DRVLLVSTDRQSAFDRALAS-VPFKSRVLTLTSVWWFNQTKHI-VAN 99

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIE 112
            +  +   +  L KK  + PVE VVR    GS    +       
Sbjct: 100 HLLGVPHPSAMLCKKCTVFPVEFVVRGYITGSTSTSMWTNYKKR 143


>UniRef50_B5YAR6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Dictyoglomus RepID=B5YAR6_DICT6
          Length = 338

 Score = 94.1 bits (233), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 59/285 (20%), Positives = 89/285 (31%), Gaps = 81/285 (28%)

Query: 10  GKAKTVYSTENP-----DLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
           G  K +   E P           F +  S  D G   +  D KG        +   KL  
Sbjct: 2   GSVKDLIVIEKPTEKKLGRGRFLFSDRYSVFDYGEMPDLIDDKGKAICIATAYFFEKLEN 61

Query: 64  AGIPTQMERLLSDTEC----------------LVKKLDM--------------------V 87
            GI T    L+ D +                 +V+ L                      +
Sbjct: 62  LGIKTHYIGLVEDDKIKTLYELKEPTNVMEFKMVRVLKPELQENIYNYSIFKKERSNFLI 121

Query: 88  PVECVVRN-RAAGSLV-KRLG--------------IEEGIELNPPLFDLFLKNDAMHDPM 131
           P+E + RN    GS V KRL                E G +L  P+ D   K +     +
Sbjct: 122 PLEVIYRNALPEGSSVFKRLKEGSLNLEEIGLDKMPEPGQKLEKPIVDFSTKLEVNDRYL 181

Query: 132 VNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLG 190
             +   E  G  S+    +++ LT   +D++ +      L   D K+E+ L  +  ++L 
Sbjct: 182 SKKEALEISGL-SETEFEKLRNLTLFIDDLITEETRKINLNNEDGKVEYALDLERNIMLV 240

Query: 191 DEF-SPDGSRL--------------------WDKETLEKMDKDRF 214
           D   + D  R                     W KE  E   KDRF
Sbjct: 241 DALGTLDECRFTFEGIPVSKEIARIYYRKTDWYKEVEEAKKKDRF 285


>UniRef50_Q9HNU7 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
           n=8 Tax=Halobacteriaceae RepID=PUR7_HALSA
          Length = 347

 Score = 93.3 bits (231), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 48/245 (19%), Positives = 82/245 (33%), Gaps = 58/245 (23%)

Query: 25  VLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQM------------- 70
           V EF +  S  D G   +    KG        +   +LA AG+PT               
Sbjct: 31  VFEFSDRYSVFDWGEMPDHVPGKGASLCTMGAYTFEQLAAAGVPTHYQGVRTPDGETVRL 90

Query: 71  -ERLLSDTECLVKKLDM------------------------VPVECVVRN-RAAGSLVK- 103
            +   + T+ ++    +                        VP+E V RN    GS ++ 
Sbjct: 91  ADAPEAPTQMVIDLTQVPTLPFEDGSYDYDRYHDAGGSNYLVPLEVVFRNAVPVGSSLRT 150

Query: 104 -----RLGIEEGI------ELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMK 152
                 +GI+         EL   + +   K +     +   S           ++A + 
Sbjct: 151 RCAPADVGIDADEWPQGPVELPETIVEFSTKYEEQDRYL---SRSMADEIAGDADIAELD 207

Query: 153 ELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEKMDK 211
            L  + N+ +     DAG +  D KLE     GEV + D   + D +R   +    ++ K
Sbjct: 208 ALARRVNETITDCAADAGFVHDDGKLECVYVDGEVRVADVAGTFDENRF--RFDGREVSK 265

Query: 212 DRFRQ 216
           +  RQ
Sbjct: 266 EAVRQ 270


>UniRef50_Q2GR92 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2GR92_CHAGB
          Length = 220

 Score = 88.7 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 27/151 (17%), Positives = 53/151 (35%), Gaps = 9/151 (5%)

Query: 32  TSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA--GIPTQMERLLSDTECLVKKLDMVPV 89
            SA D         KG +    +      L+    G+      L       + + +   +
Sbjct: 21  VSAYDVILKNGIPTKGAILTLLSAKWFEVLSSRVPGLKHHFLHLGPPPASGLSQEEQQML 80

Query: 90  E---CVVRNRAAGS---LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWV 143
                 VR +   +   L +  G++    L  P++    K + + D  +N S  E  G V
Sbjct: 81  RGRSMTVRYKETQTIHGLPQPAGLKRCERLPKPIYTPSTKAE-LGDKDINISPDEARGIV 139

Query: 144 SKENLARMKELTYKANDVLKKLFDDAGLILV 174
             +   R++EL     +      ++ G+I+V
Sbjct: 140 GDKYAGRLEELALACYNAGAAYAEERGIIIV 170


>UniRef50_B2L3L7 Phosphoribosylaminoimidazole carboxylase n=1 Tax=Philodina roseola
           RepID=B2L3L7_9BILA
          Length = 490

 Score = 88.3 bits (218), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 45/269 (16%), Positives = 85/269 (31%), Gaps = 75/269 (27%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEF---------------RNDTSAGD---------GARI 40
            +L+ GK +T+YS  +   L+                   N  ++ D          +  
Sbjct: 13  QKLFEGKTQTIYSVIDQSNLICIHQRDADDSTEILSTTSSNRRTSFDAGFRGRSRSHSLA 72

Query: 41  EQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEC-LVKKLDMVPVECVVRNRAAG 99
           E    +       N  +   L EA IP         ++  + +K  M+P+   +R  A  
Sbjct: 73  ENISTRATWITSINICVYEILREASIPNYFIAPHPQSDMFIAQKCTMIPLIWFIRRVANE 132

Query: 100 SLVKRL-GIEEGIELNPPLFDLFL-----------------------KNDAMHDPMVNES 135
           + VK+   +  G    PP+ +L                         + + + D   ++ 
Sbjct: 133 NYVKQHSNVPLGQRFVPPIVELCSQRRPIVYRRLTLSNLEETILNSDRTNVIDDENDDDV 192

Query: 136 YCETFGW------------------------VSKENLARMKELTYKANDVLKKLF-DDAG 170
             +                            +S  +L  M E+     D+L+ ++     
Sbjct: 193 EKKQLNDDDSSISIFSSDQLAHLPFDISSMKISTNDLELMYEICLTLFDILEHVWMTTKK 252

Query: 171 LILVDFKLEFGL-YKGEVVLGDEFSPDGS 198
             L+D KLEFGL    ++V+   F  D  
Sbjct: 253 YQLIDLKLEFGLTTTKDIVVAHVFDVDSW 281


>UniRef50_Q3CXY3 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Streptococcus agalactiae H36B RepID=Q3CXY3_STRAG
          Length = 92

 Score = 84.4 bits (208), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 26/74 (35%), Positives = 44/74 (59%)

Query: 103 KRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
           KR G+E G  L  P+ + + KND ++DP +N+ + +  G V+ E +A +K  T + N++L
Sbjct: 2   KRFGVEVGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELL 61

Query: 163 KKLFDDAGLILVDF 176
           K  F   G+  +DF
Sbjct: 62  KDWFAQIGITWIDF 75


>UniRef50_UPI0001746899 phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI0001746899
          Length = 440

 Score = 67.5 bits (164), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 22/135 (16%)

Query: 86  MVPVECVVRNRAAG--SLVKRL---------------GIEEG----IELNPPLFDLFLKN 124
           ++P+E +VR    G  S++++                G+ +       L  P+FDL  K+
Sbjct: 180 VIPLEYIVRFGITGGSSVLRKYASLSDADKKTYENELGLSQAMQAWQFLPRPIFDLTSKH 239

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           +   D  V +        +  +      +L+      +++L D+ GL+L D K EF + +
Sbjct: 240 EPE-DRNVTKQEAALMSGMEADAFVSTIKLSLLGAWAVRQLLDEIGLLLWDIKWEFAVDE 298

Query: 185 GEVVLGDEFSPDGSR 199
           GE    D    D  R
Sbjct: 299 GEFFFVDTIDTDSFR 313


>UniRef50_B4N726 GK23628 n=2 Tax=Drosophila willistoni RepID=B4N726_DROWI
          Length = 233

 Score = 57.9 bits (139), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 20/86 (23%), Positives = 32/86 (37%), Gaps = 9/86 (10%)

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDR 213
                VL + +      L+D K+E G+   G +VL D       RLW       M DK  
Sbjct: 1   MSCYMVLDRAWQIENCALIDMKVENGIDTDGNIVLADIIDSVSWRLWPPGDKRLMVDKQL 60

Query: 214 FRQ-------SLGGLIEAYEAVARRL 232
           +R         +  +   +  V+ +L
Sbjct: 61  YRNLTSVTSSDMDTVKRNFIWVSEQL 86


>UniRef50_Q9F8W0 SAICAR synthetase (Fragment) n=2 Tax=Rhizobium/Agrobacterium group
           RepID=Q9F8W0_RHIRD
          Length = 114

 Score = 52.5 bits (125), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 12/66 (18%)

Query: 179 EFGLY-KGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQSLGGLIEAYE 226
           EFG    G ++L DE  +PD SR W  ++ +            DKD  R  +G   + Y+
Sbjct: 1   EFGTDENGTIILADEIHTPDSSRYWMADSYDESFREGKRPASFDKDFVRAWVGERCDPYK 60

Query: 227 AVARRL 232
               ++
Sbjct: 61  DAVPKI 66


>UniRef50_Q0PQG5 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2'
           RepID=Q0PQG5_9GAMM
          Length = 184

 Score = 52.1 bits (124), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 9/39 (23%), Positives = 17/39 (43%)

Query: 148 LARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE 186
             ++++L+        +     G+I+ D K EFGL    
Sbjct: 140 AEQVRDLSLHIYTEAAEYARSKGIIIADTKFEFGLDDNR 178


>UniRef50_Q67KF5 Putative uncharacterized protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KF5_SYMTH
          Length = 179

 Score = 51.7 bits (123), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 40/207 (19%), Positives = 71/207 (34%), Gaps = 40/207 (19%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  L+ G    V++T+  D L+LEF +                          I   L 
Sbjct: 7   KRERLWAGDGLAVHATDRADRLILEFED-----------------ETVCAAALRIQEILV 49

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             G+ T      +    L++K+  +PVE       AG    RL   +G            
Sbjct: 50  GHGLATSFAARFTSRSFLIRKVQPLPVEVAAE---AGPGEVRLAFRDG------------ 94

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
                 D  ++    E    ++ E L R+++    A   L+      G+  +  ++ FGL
Sbjct: 95  ------DRELSREEAEAA--LTPERLERIEDAALHAARTLRAHLSLRGVERLQLRMRFGL 146

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKM 209
            +    L    +P   RL  ++  E +
Sbjct: 147 TEEGACLMQVMNPLECRLGSEDMKEVL 173


>UniRef50_Q46F31 Putative uncharacterized protein n=1 Tax=Methanosarcina barkeri
          str. Fusaro RepID=Q46F31_METBF
          Length = 47

 Score = 39.7 bits (92), Expect = 0.073,   Method: Composition-based stats.
 Identities = 16/27 (59%), Positives = 22/27 (81%)

Query: 4  QAELYRGKAKTVYSTENPDLLVLEFRN 30
          + +LY GKAKT+Y T++PD L+ EFRN
Sbjct: 3  REQLYSGKAKTIYKTDDPDTLITEFRN 29


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_C8PXT0 Phosphoribosylaminoimidazole-succinocarboxamide ...   301   1e-80
UniRef50_Q2NCK7 Phosphoribosylaminoimidazole-succinocarboxamide ...   297   2e-79
UniRef50_A9VRE8 Phosphoribosylaminoimidazole-succinocarboxamide ...   297   3e-79
UniRef50_A7ZPS1 Phosphoribosylaminoimidazole-succinocarboxamide ...   293   4e-78
UniRef50_C9M8K7 Phosphoribosylaminoimidazole-succinocarboxamide ...   293   4e-78
UniRef50_B1YJ02 Phosphoribosylaminoimidazole-succinocarboxamide ...   293   4e-78
UniRef50_A6Q3C7 Phosphoribosylaminoimidazole-succinocarboxamide ...   289   6e-77
UniRef50_P73471 Phosphoribosylaminoimidazole-succinocarboxamide ...   287   2e-76
UniRef50_Q8TX83 Phosphoribosylaminoimidazole-succinocarboxamide ...   287   3e-76
UniRef50_B8DTV0 Phosphoribosylaminoimidazole-succinocarboxamide ...   282   8e-75
UniRef50_Q38XX0 Phosphoribosylaminoimidazole-succinocarboxamide ...   280   3e-74
UniRef50_A0AJM6 Phosphoribosylaminoimidazole-succinocarboxamide ...   277   2e-73
UniRef50_Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide ...   275   8e-73
UniRef50_C2D8C6 Phosphoribosylaminoimidazolesuccinocarboxamide s...   274   1e-72
UniRef50_Q2GHH2 Phosphoribosylaminoimidazole-succinocarboxamide ...   273   2e-72
UniRef50_O57978 Phosphoribosylaminoimidazole-succinocarboxamide ...   273   3e-72
UniRef50_A7X0V7 Phosphoribosylaminoimidazole-succinocarboxamide ...   273   3e-72
UniRef50_Q03E76 Phosphoribosylaminoimidazole-succinocarboxamide ...   270   2e-71
UniRef50_B9EAY5 Phosphoribosylaminoimidazole-succinocarboxamide ...   268   7e-71
UniRef50_Q049L4 Phosphoribosylaminoimidazole-succinocarboxamide ...   268   9e-71
UniRef50_A4SE69 Phosphoribosylaminoimidazole-succinocarboxamide ...   268   1e-70
UniRef50_C6I122 Phosphoribosylaminoimidazole-succinocarboxamide ...   268   1e-70
UniRef50_Q1AXB9 Phosphoribosylaminoimidazole-succinocarboxamide ...   267   3e-70
UniRef50_A4FYT6 Phosphoribosylaminoimidazole-succinocarboxamide ...   266   4e-70
UniRef50_B5IMM2 Phosphoribosylaminoimidazole-succinocarboxamide ...   265   9e-70
UniRef50_D2EKX6 Phosphoribosylaminoimidazole-succinocarboxamide ...   265   1e-69
UniRef50_Q3AHS3 Phosphoribosylaminoimidazole-succinocarboxamide ...   264   1e-69
UniRef50_Q7V0C7 Phosphoribosylaminoimidazole-succinocarboxamide ...   263   2e-69
UniRef50_O26272 Phosphoribosylaminoimidazole-succinocarboxamide ...   263   2e-69
UniRef50_A9BIH1 Phosphoribosylaminoimidazole-succinocarboxamide ...   260   4e-68
UniRef50_D0JBF3 Phosphoribosylaminoimidazole-succinocarboxamide ...   256   5e-67
UniRef50_P22234 Phosphoribosylaminoimidazole carboxylase n=88 Ta...   253   3e-66
UniRef50_B8GCM2 Phosphoribosylaminoimidazole-succinocarboxamide ...   252   6e-66
UniRef50_B8D414 Phosphoribosylaminoimidazolesuccinocarboxamide s...   249   5e-65
UniRef50_Q03Y92 Phosphoribosylaminoimidazole-succinocarboxamide ...   246   5e-64
UniRef50_C2U7A6 Phosphoribosylaminoimidazole-succinocarboxamide ...   245   1e-63
UniRef50_A8MCJ8 Phosphoribosylaminoimidazole-succinocarboxamide ...   243   4e-63
UniRef50_UPI00006A4774 PREDICTED: similar to phosphoribosylamino...   243   5e-63
UniRef50_Q47KH4 Phosphoribosylaminoimidazole-succinocarboxamide ...   241   1e-62
UniRef50_Q8D2M4 Phosphoribosylaminoimidazole-succinocarboxamide ...   241   2e-62
UniRef50_C6XGE3 Phosphoribosylaminoimidazole-succinocarboxamide ...   240   3e-62
UniRef50_A8ZVI6 Phosphoribosylaminoimidazole-succinocarboxamide ...   238   9e-62
UniRef50_A1VU36 Phosphoribosylaminoimidazole-succinocarboxamide ...   238   1e-61
UniRef50_Q5X4M9 Phosphoribosylaminoimidazole-succinocarboxamide ...   238   1e-61
UniRef50_D0MIB5 Phosphoribosylaminoimidazolesuccinocarboxamidesy...   238   1e-61
UniRef50_Q4J8G0 Phosphoribosylaminoimidazole-succinocarboxamide ...   238   1e-61
UniRef50_A3MXE4 Phosphoribosylaminoimidazole-succinocarboxamide ...   238   1e-61
UniRef50_B4Q3U0 GD23841 n=2 Tax=melanogaster subgroup RepID=B4Q3...   237   2e-61
UniRef50_A9VBB9 Phosphoribosylaminoimidazole-succinocarboxamide ...   237   3e-61
UniRef50_Q9VK80 CG17024 n=4 Tax=melanogaster group RepID=Q9VK80_...   234   2e-60
UniRef50_B1LCA5 Phosphoribosylaminoimidazole-succinocarboxamide ...   234   2e-60
UniRef50_A6LDF8 Phosphoribosylamidoimidazole-succinocarboxamide ...   233   3e-60
UniRef50_C4FB69 Phosphoribosylaminoimidazole-succinocarboxamide ...   233   4e-60
UniRef50_B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide ...   232   8e-60
UniRef50_C6BVA6 Phosphoribosylaminoimidazole-succinocarboxamide ...   232   8e-60
UniRef50_Q313T8 Phosphoribosylaminoimidazole-succinocarboxamide ...   232   1e-59
UniRef50_B8IQA8 Phosphoribosylaminoimidazole-succinocarboxamide ...   232   1e-59
UniRef50_C1A3U9 Phosphoribosylaminoimidazole-succinocarboxamide ...   231   1e-59
UniRef50_A7H9G3 Phosphoribosylaminoimidazolesuccinocarboxamide s...   231   1e-59
UniRef50_B5GT63 Phosphoribosylaminoimidazole-succinocarboxamide ...   231   1e-59
UniRef50_Q8UCE7 Putative phosphoribosylaminoimidazole-succinocar...   231   2e-59
UniRef50_C9KPE2 Phosphoribosylaminoimidazole-succinocarboxamide ...   231   2e-59
UniRef50_B2KCE9 Phosphoribosylaminoimidazole-succinocarboxamide ...   230   4e-59
UniRef50_A6GYJ4 Phosphoribosylaminoimidazole-succinocarboxamide ...   230   4e-59
UniRef50_B5JQ22 Phosphoribosylaminoimidazole-succinocarboxamide ...   229   5e-59
UniRef50_A8LCN0 Phosphoribosylaminoimidazole-succinocarboxamide ...   229   8e-59
UniRef50_Q648Z8 Phosphoribosylaminoimidazolesuccinocarboxamide s...   227   2e-58
UniRef50_Q9UUB4 Phosphoribosylaminoimidazole-succinocarboxamide ...   225   8e-58
UniRef50_A8AAS3 Phosphoribosylaminoimidazole-succinocarboxamide ...   225   9e-58
UniRef50_A4SAQ9 Phosphoribosylaminoimidazole-succinocarboxamide ...   225   1e-57
UniRef50_Q72UH8 Phosphoribosylaminoimidazole-succinocarboxamide ...   224   2e-57
UniRef50_Q7UJ19 Phosphoribosylaminoimidazole-succinocarboxamide ...   224   2e-57
UniRef50_C0A6D3 Phosphoribosylaminoimidazolesuccinocarboxamide s...   221   2e-56
UniRef50_Q11TT6 Phosphoribosylaminoimidazole-succinocarboxamide ...   220   4e-56
UniRef50_P38025 Phosphoribosylaminoimidazole-succinocarboxamide ...   220   4e-56
UniRef50_B0VH32 Phosphoribosylaminoimidazole-succinocarboxamide ...   219   6e-56
UniRef50_A7BA15 Phosphoribosylaminoimidazole-succinocarboxamide ...   218   1e-55
UniRef50_A9A5G9 Phosphoribosylaminoimidazole-succinocarboxamide ...   218   1e-55
UniRef50_C6CV28 Phosphoribosylaminoimidazolesuccinocarboxamide s...   216   3e-55
UniRef50_B7FS23 Phosphoribosylaminoimidazole-succinocarboxamide ...   216   4e-55
UniRef50_Q3Z881 Phosphoribosylaminoimidazole-succinocarboxamide ...   216   7e-55
UniRef50_Q67KF6 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   8e-55
UniRef50_Q5P7J7 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   8e-55
UniRef50_P27616 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   1e-54
UniRef50_Q73PW0 Phosphoribosylaminoimidazole-succinocarboxamide ...   215   1e-54
UniRef50_B0U1N3 Phosphoribosylaminoimidazole-succinocarboxamide ...   213   3e-54
UniRef50_UPI000187DCD8 hypothetical protein MPER_11578 n=1 Tax=M...   213   4e-54
UniRef50_C7NLA9 Phosphoribosylaminoimidazole-succinocarboxamide ...   210   3e-53
UniRef50_D0LZ80 Phosphoribosylaminoimidazolesuccinocarboxamidesy...   209   5e-53
UniRef50_A8GML2 Phosphoribosylaminoimidazole-succinocarboxamide ...   209   8e-53
UniRef50_B3V647 Phosphoribosylaminoimidazole-succinocarboxamide ...   207   2e-52
UniRef50_A5CCM2 Phosphoribosylaminoimidazole-succinocarboxamides...   207   2e-52
UniRef50_Q9P9D8 SAICAR synthase n=1 Tax=uncultured marine group ...   206   6e-52
UniRef50_B3T553 Putative SAICAR synthetase n=2 Tax=prokaryotic e...   201   2e-50
UniRef50_B3DVV2 Phosphoribosylaminoimidazolesuccinocarboxamide (...   198   1e-49
UniRef50_C7M1W2 Phosphoribosylaminoimidazolesuccinocarboxamide s...   195   9e-49
UniRef50_Q9HLC0 Phosphoribosylaminoimidazole-succinocarboxamide ...   193   5e-48
UniRef50_Q94IQ2 Phosphoribosylaminoimidazole-succinocarboxamide ...   192   8e-48
UniRef50_UPI0001926A10 PREDICTED: similar to phosphoribosylamino...   190   4e-47
UniRef50_Q978V1 Phosphoribosylaminoimidazole-succinocarboxamide ...   187   2e-46
UniRef50_Q83GX1 Phosphoribosylaminoimidazole-succinocarboxamide ...   185   1e-45
UniRef50_UPI000038E095 phosphoribosylaminoimidazole-succinocarbo...   185   1e-45
UniRef50_C5A6A8 Phosphoribosylaminoimidazole-succinocarboxamide ...   184   2e-45
UniRef50_B8J393 Phosphoribosylaminoimidazolesuccinocarboxamide s...   184   3e-45
UniRef50_B2A872 Phosphoribosylaminoimidazole-succinocarboxamide ...   179   6e-44
UniRef50_C7RD67 Phosphoribosylaminoimidazole-succinocarboxamide ...   176   6e-43
UniRef50_Q895U7 Phosphoribosylaminoimidazole-succinocarboxamide ...   169   6e-41
UniRef50_Q7MLF9 Phosphoribosylaminoimidazole-succinocarboxamide ...   168   2e-40
UniRef50_Q466M0 Phosphoribosylaminoimidazole-succinocarboxamide ...   165   1e-39
UniRef50_Q6NRP1 LOC431975 protein (Fragment) n=2 Tax=Xenopus Rep...   162   8e-39
UniRef50_A8M140 SAICAR synthetase n=1 Tax=Salinispora arenicola ...   157   3e-37
UniRef50_A4NXH0 Phosphoribosylaminoimidazole-succinocarboxamide ...   156   4e-37
UniRef50_A8M136 SAICAR synthetase n=1 Tax=Salinispora arenicola ...   156   6e-37
UniRef50_B5GV74 Saicar synthetase n=1 Tax=Streptomyces clavulige...   153   3e-36
UniRef50_Q6MIY7 Phosphoribosylaminoimidazolesuccinocarboxamide s...   151   1e-35
UniRef50_D2RHF2 Phosphoribosylaminoimidazole-succinocarboxamide ...   150   4e-35
UniRef50_A8EWL2 Phosphoribosylaminoimidazole-succinocarboxamide ...   149   7e-35
UniRef50_O28996 Putative phosphoribosylaminoimidazole-succinocar...   146   5e-34
UniRef50_Q3IMR8 Phosphoribosylaminoimidazolesuccinocarboxamide s...   145   9e-34
UniRef50_B2L3N2 Phosphoribosylaminoimidazole carboxylase n=3 Tax...   139   6e-32
UniRef50_D1JGB5 Putative phosphoribosylaminoimidazole-succinocar...   139   7e-32
UniRef50_Q9HNU7 Putative phosphoribosylaminoimidazole-succinocar...   138   1e-31
UniRef50_B3G3Y1 Saicars n=1 Tax=Adineta vaga RepID=B3G3Y1_ADIVA       129   6e-29
UniRef50_B5YAR6 Phosphoribosylaminoimidazole-succinocarboxamide ...   129   1e-28
UniRef50_Q5IWX2 Plastid phosphoribosylaminoimidazole-succinocarb...   126   6e-28
UniRef50_B2L3L7 Phosphoribosylaminoimidazole carboxylase n=1 Tax...   124   2e-27
UniRef50_Q2GR92 Putative uncharacterized protein n=1 Tax=Chaetom...   117   2e-25
UniRef50_Q67KF5 Putative uncharacterized protein n=1 Tax=Symbiob...   114   3e-24
UniRef50_UPI00015FF598 UPI00015FF598 related cluster n=1 Tax=Dro...   111   2e-23
UniRef50_D0NC79 Phosphoribosylaminoimidazole-succinocarboxamide ...   110   5e-23
UniRef50_UPI0001746899 phosphoribosylaminoimidazolesuccinocarbox...    92   1e-17
UniRef50_Q3CXY3 Phosphoribosylaminoimidazole-succinocarboxamide ...    85   2e-15
UniRef50_B4N726 GK23628 n=2 Tax=Drosophila willistoni RepID=B4N7...    75   2e-12
UniRef50_Q9F8W0 SAICAR synthetase (Fragment) n=2 Tax=Rhizobium/A...    59   1e-07
UniRef50_Q0PQG5 Phosphoribosylaminoimidazole-succinocarboxamide ...    55   2e-06

Sequences not found previously or not previously below threshold:

UniRef50_Q5B800 Predicted protein n=3 Tax=Leotiomyceta RepID=Q5B...    54   5e-06
UniRef50_Q46F31 Putative uncharacterized protein n=1 Tax=Methano...    40   0.066

>UniRef50_C8PXT0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Gammaproteobacteria RepID=C8PXT0_9GAMM
          Length = 242

 Score =  301 bits (771), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 152/236 (64%), Positives = 188/236 (79%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK   LY+GKAK+V+ T+NPD L+LEFR+DTSA +G RIEQ  RKG VNN+FN FIM K
Sbjct: 1   MQKLDLLYKGKAKSVFETDNPDYLILEFRDDTSAFNGERIEQLARKGKVNNRFNAFIMQK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L+EAGI T  E+ LSD E LVK+L M+PVECVVRN AAGSLV+RLG++EG  L PP F+L
Sbjct: 61  LSEAGIETHFEQQLSDEEVLVKRLTMIPVECVVRNYAAGSLVRRLGLQEGQALTPPTFEL 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DPMVN+S   + GW ++  L  MK LT+K NDVL K+FDD GL+LVDFKLEF
Sbjct: 121 FYKDDGLGDPMVNDSLAVSLGWATQAQLDEMKALTFKVNDVLSKMFDDGGLMLVDFKLEF 180

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQL 236
           G++K  +VLGDEFSPDG R+WDK+T +K+DKDRFRQSLG ++E YE VA+R+GV L
Sbjct: 181 GVFKDRIVLGDEFSPDGCRVWDKQTKKKLDKDRFRQSLGDVVEGYEEVAKRIGVSL 236


>UniRef50_Q2NCK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=346
           Tax=cellular organisms RepID=PUR7_ERYLH
          Length = 272

 Score =  297 bits (761), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 97/239 (40%), Positives = 146/239 (61%), Gaps = 4/239 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M ++ ++Y GKAK +Y    P  ++  F++D +A +  +      KG++NN+ +  + ++
Sbjct: 1   MSRRRQIYEGKAKILYEGPEPGTIIQYFKDDATAFNAEKKGTISGKGVINNRISEHVFTR 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L+  GIPT   R L+  E LV++ +++P+E VVRN AAGS+ KRLGI EG  L   L + 
Sbjct: 61  LSHIGIPTHFIRRLNMREQLVRQCEIIPIEVVVRNVAAGSISKRLGIPEGEPLPHTLIEY 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D++ DP++ E +   F W S E +  +  +  + ND +  +F    + LVDFKLEF
Sbjct: 121 YYKDDSLGDPLIAEEHIACFNWASPEEMQDIASMAIRINDFMAGMFAAIDIRLVDFKLEF 180

Query: 181 GL----YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
           G         V+L DE SPDG RLWD  + EK+DKDRFR+ LGG  EAY+ VARRLG+ 
Sbjct: 181 GRIYDGDFSRVILADEISPDGCRLWDMNSGEKLDKDRFRRDLGGESEAYQEVARRLGLL 239


>UniRef50_A9VRE8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=155
           Tax=cellular organisms RepID=PUR7_BACWK
          Length = 239

 Score =  297 bits (760), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 101/234 (43%), Positives = 145/234 (61%), Gaps = 1/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK   LY GKAK +Y TE  D++ +E+++  +A +G +      KG +NN+    +  K
Sbjct: 1   MQKLELLYEGKAKRIYRTEAADMVWVEYKDSATAFNGEKKATITGKGRLNNEITTLLFRK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T     LSDTE LVKK+ ++P+E V RN  AGSL KRLG+EEG  L  P+ + 
Sbjct: 61  LQEVGIKTHFVEKLSDTEQLVKKVSIIPLEVVTRNVIAGSLSKRLGMEEGTALTTPIVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D + DP+V E +       + E ++ +++   + N V+ + F    + LVDFKLEF
Sbjct: 121 YYKDDDLGDPLVTEDHIRLLNVATPEQVSVLRDAALQINQVMIEHFASCRVRLVDFKLEF 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G+  +GE++L DE SPD  RLWD+ + EK DKD FR+ LG L EAYE + +RLG
Sbjct: 181 GVTEEGEIILADEISPDTCRLWDETSNEKFDKDVFRRDLGNLTEAYEEILKRLG 234


>UniRef50_A7ZPS1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=182
           Tax=Gammaproteobacteria RepID=PUR7_ECO24
          Length = 237

 Score =  293 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 237/237 (100%), Positives = 237/237 (100%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK
Sbjct: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL
Sbjct: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF
Sbjct: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD 237
           GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD
Sbjct: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQLD 237


>UniRef50_C9M8K7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Jonquetella anthropi E3_33 E1 RepID=C9M8K7_9BACT
          Length = 251

 Score =  293 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 90/232 (38%), Positives = 156/232 (67%), Gaps = 1/232 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK ++ST++P++L++++++  +A +  + ++   KG +NN  + +I + LA+ 
Sbjct: 16  ELLYEGKAKKIFSTDDPNVLLVQYKDSLTAFNAKKRDEKAGKGHLNNVISSWIFTWLAKK 75

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+ +   + + +T  L++K++++P+E +VRN   GSL +RLG+EEG +L+ P+ +   K+
Sbjct: 76  GVESHFIKQVDETHQLIRKVEIIPLETIVRNVTTGSLCRRLGVEEGKKLSRPIIEFSYKS 135

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           DA+ DP++N+ +    GW ++E +A +K +  K N +L +LF   G++LVDFKLEFG  +
Sbjct: 136 DALDDPLINDDHAIVLGWATEEEVATIKSIALKVNKLLTELFASVGVLLVDFKLEFGRDE 195

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
            G V+L DE SPD  R WD +T + +DKDRFR+ LG ++ AYE + RRL  +
Sbjct: 196 KGRVLLADEISPDTCRFWDSKTHDHLDKDRFRKDLGDVLGAYEEIWRRLSAR 247


>UniRef50_B1YJ02 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Bacteria RepID=PUR7_EXIS2
          Length = 235

 Score =  293 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 97/230 (42%), Positives = 149/230 (64%), Gaps = 1/230 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK +Y+T++ D+L + ++++ +A +G +  +F  KG +NN+        LA A
Sbjct: 2   QPLYEGKAKRLYTTQDQDVLRIVYKDEATAFNGEKKAEFAGKGELNNRLTSHFFEVLAAA 61

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GIPT      S+ E LV+++ ++P+E VVRN  AGSL KRLGIEEG  L  P+ + + K+
Sbjct: 62  GIPTHFIEQTSEREQLVRRVTIIPLEVVVRNVVAGSLSKRLGIEEGTVLETPIVEFYYKD 121

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           D++ DP+V  ++       + E L+ +++   + NDVL+  FD+ G+ L+DFKLE+G   
Sbjct: 122 DSLGDPLVTPAHINLLKIATTEELSLLEQEANRVNDVLRPYFDEKGITLIDFKLEYGKTP 181

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
            GE++L DE SPD  RLWDKET E +DKD FR+++G LI+ Y+ +  RLG
Sbjct: 182 AGEILLADEISPDTCRLWDKETGEHLDKDVFRRNIGSLIDTYQTLFNRLG 231


>UniRef50_A6Q3C7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=17
           Tax=Epsilonproteobacteria RepID=PUR7_NITSB
          Length = 239

 Score =  289 bits (740), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 99/234 (42%), Positives = 142/234 (60%), Gaps = 2/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   LY GKAK ++ T++ ++L+ EF++  +A D  +  +   KG +N K +  +   
Sbjct: 1   MKKTELLYEGKAKKIWKTDDENILIAEFKDSLTAFDAQKKSEEAGKGALNCKISANLFKL 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T     +S+ E ++KK +M+ +E VVRN A GSL KRLGI +G +L   L + 
Sbjct: 61  LEEQGIKTHFVECISENEMVIKKAEMIMIEVVVRNIATGSLTKRLGIPDGTKLPFALVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKE-NLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
           + KNDA+HDP++N+ +      V  E  L  +K L  + N VLK  FD A L LVDFK+E
Sbjct: 121 YYKNDALHDPLINDEHALILELVDHESELEELKRLGREINVVLKSFFDKANLNLVDFKVE 180

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           FG   +G ++L DE SPD  R WDK + EK+DKD FR  LG +  AYE V +R+
Sbjct: 181 FGKDSEGNIILADEISPDSCRFWDKTSGEKLDKDLFRHDLGNVKVAYEEVLKRI 234


>UniRef50_P73471 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=69
           Tax=Bacteria RepID=PUR7_SYNY3
          Length = 264

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 90/238 (37%), Positives = 139/238 (58%), Gaps = 5/238 (2%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            +LY GKAK +Y TE+PD+L+  F++D +A +  +  Q   KG +N   +  +   L   
Sbjct: 18  EKLYEGKAKILYPTEDPDVLLTIFKDDATAFNAQKKGQIQGKGAINCAISAALFRWLETL 77

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GIPT       + + LVK ++++P+E VVRN AAGSL K+ G++EG+ L  PL + + K+
Sbjct: 78  GIPTHYIDCPQNDQMLVKAVNIIPLEVVVRNIAAGSLCKQTGLKEGLVLPNPLVEFYFKD 137

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           DA+ DP++        G   +  L  +K+L    N  L++ F    + LVDFKLEFG   
Sbjct: 138 DALGDPLLTWERALLLGVTDEARLQTLKDLALNINQHLQRFFAQCDITLVDFKLEFGGDR 197

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEK----MDKDRFRQSLGGLIEAYEAVARRLGVQLD 237
           +G+++L DE SPD  RLWD    +     +DKDRFR+ LG +  AY+ V +R+  Q++
Sbjct: 198 QGKIILADEISPDTCRLWDNAQADPQARVLDKDRFRRDLGSIEAAYQTVEKRVLSQIE 255


>UniRef50_Q8TX83 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=cellular organisms RepID=PUR7_METKA
          Length = 247

 Score =  287 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 99/234 (42%), Positives = 146/234 (62%), Gaps = 2/234 (0%)

Query: 1   MQKQAELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M++   +Y GKAK++Y   E+ +LLV+EFR+D +A +  +++  + KG+ N   +  +  
Sbjct: 1   MERGRLVYEGKAKSLYEHPEDENLLVMEFRDDITAFNMEKMDTVEGKGVYNCLISARLFE 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L +AGIPT    L  +   +V++LDM  +E + RN A GSLV+RL  EEG +L+PP+ +
Sbjct: 61  VLEDAGIPTHYVELADERRMVVERLDMFNLEVICRNMATGSLVERLPFEEGEKLDPPIVE 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K+D   DPMVN  +    G  ++E + RM+ELT + N+VL +   D  +ILVDFKLE
Sbjct: 121 FDYKSDEYGDPMVNMDHIRALGLATEEEVERMRELTLQVNEVLSEFLKDCDIILVDFKLE 180

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           FG+   GEVV+GDE SPD  R WD ET E +DKD FR+  G ++  Y   A R+
Sbjct: 181 FGVNPDGEVVVGDEISPDTCRFWDAETEESLDKDIFRKDEGDVLAGYREAAERI 234


>UniRef50_B8DTV0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=16
           Tax=Bacteria RepID=PUR7_BIFA0
          Length = 250

 Score =  282 bits (721), Expect = 8e-75,   Method: Composition-based stats.
 Identities = 99/237 (41%), Positives = 143/237 (60%), Gaps = 5/237 (2%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK  +LY GKAK +Y+T++PD+L +E+ N  +AG+GA+  Q + KG +NN+    I   
Sbjct: 1   MQKLDKLYEGKAKKLYATDDPDVLWVEYMNQATAGNGAKKAQIEGKGELNNQITSVIFDL 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI +   + +SDTE LV+K+DM P+E ++RN AAGS  KR G+EEG  L+ P+ + 
Sbjct: 61  LKARGIDSHFVKRISDTEQLVRKMDMYPLEIIMRNTAAGSFAKRYGVEEGTALDKPILEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
            +K+D + DP +N+      G  S+E L  +       ND LK +F    + LVDFK+E 
Sbjct: 121 CVKSDELGDPFINDDGIVALGIASEEELDEISRQARAVNDALKDIFSKIDVQLVDFKIEE 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETL----EKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    G ++L DE +PD  RLWD +      E +DKD FR+ LG +I AYE +  RL
Sbjct: 181 GKTGDGRILLADEITPDTCRLWDLKDGSGQIEHLDKDLFRRDLGNIIPAYEEIYDRL 237


>UniRef50_Q38XX0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=27
           Tax=Lactobacillales RepID=PUR7_LACSS
          Length = 241

 Score =  280 bits (716), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 95/228 (41%), Positives = 148/228 (64%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK ++ST++P++L + +++  +A +G R EQ   KG VN + +  I + L++ 
Sbjct: 4   TLLYSGKAKDLFSTDDPEVLKMIYKDQATALNGKRKEQITGKGEVNYEISKLIFAYLSQQ 63

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GI T + + +S+TE LVKK+ ++P+E V+RN  AGS  ++ G   G  L  P+ + + KN
Sbjct: 64  GIETHLIKNVSETEQLVKKVTIIPLEVVLRNVVAGSFARKFGQPLGQRLEQPIIEYYYKN 123

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           DA+ DP +N S       V+   +A ++ +T + N +L KLF++ G+ L+DFKLEFG Y+
Sbjct: 124 DALDDPAINISQATALKLVTPTEVATIEAMTKQINTLLIKLFNEIGIDLIDFKLEFGRYQ 183

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G ++L DEFSPD  RLWD++T   +DKD FRQ+ G L+  YE V +RL
Sbjct: 184 GRLILADEFSPDNCRLWDQKTHSSLDKDVFRQNKGDLVTVYETVLQRL 231


>UniRef50_A0AJM6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=66
           Tax=Bacteria RepID=PUR7_LISW6
          Length = 237

 Score =  277 bits (709), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 95/231 (41%), Positives = 141/231 (61%), Gaps = 1/231 (0%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
              +Y GKAK ++ TE   +L + +++D +A +G R E F  KG +NN+    I S L E
Sbjct: 3   NELVYEGKAKQLFKTEEAGVLRVAYKDDATALNGVRKESFAGKGELNNQITALIFSYLEE 62

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
           AGI +   R +S+TE LVK++ ++P+E VVRN  AGSL KRLG EEG E+   + + + K
Sbjct: 63  AGIRSHFIRAISETEQLVKEVSIIPLEVVVRNVIAGSLAKRLGKEEGEEIPSAIVEFYYK 122

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
            DA+ DP +N+ +       +   +  +++     N+VL+ LF+   + L+DFKLEFG  
Sbjct: 123 EDALDDPFINDDHVLYLEIATTNEMEVIRKAARSINEVLQVLFNQMNITLIDFKLEFGRD 182

Query: 184 -KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
             G ++L DE SPD  RLWDKET +K+DKD FR+++G L + Y  V  RL 
Sbjct: 183 ADGNILLADEISPDTCRLWDKETKQKLDKDVFRRNIGNLTDVYTEVLNRLK 233


>UniRef50_Q12UF8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Methanomicrobia RepID=PUR7_METBU
          Length = 238

 Score =  275 bits (704), Expect = 8e-73,   Method: Composition-based stats.
 Identities = 99/230 (43%), Positives = 134/230 (58%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K  ELY GKAKT+Y TENP+ L+ EFR+  +A DG +  +   KG  N + +  I   L 
Sbjct: 2   KTEELYSGKAKTIYKTENPNELISEFRDSLTAFDGKKKSEATNKGYYNAQISKKIFEMLE 61

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
           E GI T    ++S  E LVKK+D++ +E + RN AAGS+ ++  +EEG     P+     
Sbjct: 62  EEGIKTHYLGMVSGNEMLVKKVDIILIEVIPRNIAAGSITRKYPVEEGTVFKEPVLVFDY 121

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           K+D   DPM+N+      G  ++E +  ++ +  K N +LK   +  G +L DFKLEFG 
Sbjct: 122 KSDEFGDPMINDDIAVVMGIATREEIDFIRSMALKINAILKSYLESNGFLLPDFKLEFGR 181

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
             GE+VL DE S D  R WD ET E MDKD FR   G L +AYE VARRL
Sbjct: 182 VDGEIVLADEISCDTCRFWDVETGESMDKDLFRFDKGDLSKAYEKVARRL 231


>UniRef50_C2D8C6 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Atopobium vaginae DSM 15829 RepID=C2D8C6_9ACTN
          Length = 238

 Score =  274 bits (702), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 112/233 (48%), Positives = 150/233 (64%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           MQK    Y GKAK +Y T++P LL + +++  +AGDGA+ EQ   KG +N K    I + 
Sbjct: 1   MQKGKLSYVGKAKDMYETDDPRLLWMVYKDQATAGDGAKKEQIAGKGELNQKITRLIFAY 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           LA+ GI T +++++SDTE LV+KLDM  +E V+RN AAGS+V+RLGIE+G E    + + 
Sbjct: 61  LADHGIKTHLKKIISDTEELVEKLDMFELEVVLRNLAAGSIVRRLGIEKGTEFKGGMIEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D +HDP++ +         +   L  +K LT + N +L +LF  AGLILVDFKLEF
Sbjct: 121 YYKSDDLHDPLLTDDNLMFMHLATPAQLQEIKRLTLEVNTLLTELFKRAGLILVDFKLEF 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    GEVVLGDEFSPD  RLWD  T E  DKD FR S   +I  Y+AV  RL
Sbjct: 181 GTNADGEVVLGDEFSPDNCRLWDVHTHESFDKDIFRNSDEDMIPFYKAVYERL 233


>UniRef50_Q2GHH2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=Rickettsiales RepID=PUR7_EHRCR
          Length = 242

 Score =  273 bits (700), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 94/238 (39%), Positives = 150/238 (63%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+ + ++Y GKAK +++T NP  ++  F+++ +A +  +      KG++NN  + F+M K
Sbjct: 1   MENKEKIYEGKAKIIFATLNPLEVIQHFKDEITAFNNKKAAIIHEKGILNNYISSFLMKK 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L + GI T    LL+  E LVKK+ ++P+E V+RN AAG+  KR  I +G     P+ + 
Sbjct: 61  LIDKGIKTHFISLLNQREQLVKKITIIPIEVVIRNLAAGNFSKRFQIADGTPFKSPIIEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + KND + DPMV+E +  +F W++ + L ++K L+ K N++L +LF + G+ LVDFKLEF
Sbjct: 121 YYKNDELSDPMVSEGHILSFQWLTNQELEKIKILSLKINNILSELFFNVGIKLVDFKLEF 180

Query: 181 GL----YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G      + ++ L DE SPD  RLWD  T +++DKDR+R +LG +IE Y  VA +L  
Sbjct: 181 GKLHNDEQSDLFLADEISPDTCRLWDISTNKRLDKDRYRLNLGNVIEGYREVAHKLNA 238


>UniRef50_O57978 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=7
           Tax=cellular organisms RepID=PUR7_PYRHO
          Length = 238

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 100/233 (42%), Positives = 142/233 (60%), Gaps = 3/233 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M K  E+Y GKAK +   ++ D L++EF++D +A DG +  +F  KG +N + +      
Sbjct: 1   MVKLMEVYEGKAKKMIPIDD-DKLIMEFKDDATAFDGTKKARFKGKGWLNAQLSVIFFKL 59

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E GI T    +      +V+KLDM P+E VVRN  AGSL KRL + EG EL  P+ +L
Sbjct: 60  LEEHGIKTHFIGVAGGNRLIVEKLDMYPLEVVVRNVVAGSLKKRLPLPEGYELPEPIVEL 119

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + KND +HDPM+N  + +  G  S + + +++E+  K N++LK      G+ILVDFKLEF
Sbjct: 120 YYKNDELHDPMINYYHAKVLGI-SLDEIKKIEEIALKVNEILKDYLAKKGIILVDFKLEF 178

Query: 181 GLYK-GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G  K G++VL DE SPD  R WD +T   +DKD FR   G LIEAY+ +  R+
Sbjct: 179 GKDKNGDIVLADEISPDTCRFWDAKTKRSLDKDVFRFDKGDLIEAYKEIYERI 231


>UniRef50_A7X0V7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=58
           Tax=Bacilli RepID=PUR7_STAA1
          Length = 234

 Score =  273 bits (699), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 95/229 (41%), Positives = 141/229 (61%), Gaps = 1/229 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY GKAK ++ST   + L +E++++ +AG+GA+ +    KG +NN+    I   L E 
Sbjct: 2   TLLYEGKAKRIFSTNQENELRVEYKDEVTAGNGAKKDTMAGKGRLNNQITSIIFKYLQEN 61

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           GI +   + LS+TE LVK + ++P+E VVRN A+GS+ KRLG E G     PL + F KN
Sbjct: 62  GIESHFIKQLSETEQLVKPVKIIPLEVVVRNIASGSITKRLGFENGEVFREPLVEFFYKN 121

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           DA++DP++ + + +     S E++  +K    K N+VLK+L D   L LVDFK+EFG  +
Sbjct: 122 DALNDPLITDDHVKLLNIASDEDIEILKSKALKINNVLKQLMDAMNLKLVDFKIEFGKTE 181

Query: 185 -GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G+++L DE SPD  R+WDK T    DKD +R + G LIE Y+    +L
Sbjct: 182 TGQILLADEISPDTCRIWDKATNANFDKDVYRNNTGSLIETYQIFLNKL 230


>UniRef50_Q03E76 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=15
           Tax=Bacilli RepID=PUR7_PEDPA
          Length = 242

 Score =  270 bits (692), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 83/234 (35%), Positives = 132/234 (56%), Gaps = 1/234 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   +  GKAK +Y+T+  DL+ +E+ +  +A +G R +    KG +NN+ +  +  +
Sbjct: 1   MKKTTLIKEGKAKRLYNTDEKDLVWVEYMDQATALNGKRKDHIAGKGELNNQIDCILFEQ 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI T   + LS+ E L +K+ ++P+E VVRN A+GS  ++  +      + P+ + 
Sbjct: 61  LVAKGIHTDFVQKLSNNEQLNRKVKIIPLEVVVRNAASGSFQRKFDVSYLQAFDQPVVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DP +N +       +  E   R++++  + N +LK+ F  A L LVDFK+EF
Sbjct: 121 FYKSDELDDPFINTNKAIALKIIDLEESQRLEKMALEINQILKERFAKAHLQLVDFKVEF 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
           G     E+VL DE SPD  RL D  T E +DKD FR+  G L+  Y+ V  RL 
Sbjct: 181 GKTADDEIVLADEISPDSCRLVDLTTKESLDKDVFRKKTGDLVTVYQEVLNRLN 234


>UniRef50_B9EAY5 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Macrococcus caseolyticus JCSC5402 RepID=PUR7_MACCJ
          Length = 233

 Score =  268 bits (687), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 90/232 (38%), Positives = 143/232 (61%), Gaps = 1/232 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             +Y GKAK VYST+   +  +E++++ +AG+GA+ +    KG +NN    +   +LA  
Sbjct: 2   TLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLARQ 61

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
           G+ +   + LSDTE LVK + ++P+E VVRN AAGS+VKRLG ++G++   PL + + K 
Sbjct: 62  GLESHFIKKLSDTEQLVKAVTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYKE 121

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           DA++DP++ + + +  G    +++A +K      ND+L K+ D+  L L+DFK+EFG   
Sbjct: 122 DALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLVKMMDEMNLQLIDFKIEFGKDQ 181

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
            G ++L DE SPD  R+WDK+T E  DKD +R+  G LI+ Y     +L   
Sbjct: 182 DGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKLEAL 233


>UniRef50_Q049L4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Lactobacillus delbrueckii subsp. bulgaricus
           RepID=Q049L4_LACDB
          Length = 240

 Score =  268 bits (686), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 102/231 (44%), Positives = 154/231 (66%), Gaps = 2/231 (0%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             LY+GK K +++T++P++L   +++D +A DG + + F  KG ++ + +  +   L + 
Sbjct: 3   ELLYQGKTKEMWTTDDPEVLRAVYKDDATALDGLKHDVFQNKGELDAEISSLVFEYLMKH 62

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIE-EGIELNPPLFDLFLK 123
           G+ T   + LS  E LVKK+ M+ +E V RN AAGS  KR G++ EG +L+ P+ +LF+K
Sbjct: 63  GVKTHFIKRLSKNEQLVKKVKMIDLEVVTRNIAAGSFCKRYGLKEEGEKLDTPVEELFMK 122

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG-L 182
           +DA+HDP++NES    F  ++ E   ++ E++ + N +L KLF DAG++LVDFK+EFG L
Sbjct: 123 SDALHDPLMNESDAIAFHLLTHEEHEQIWEISRQVNQLLTKLFADAGMLLVDFKVEFGTL 182

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
             GEVVL DEFSPD  RLWD ET + MDKD +R+ +G LI+ YE V  RL 
Sbjct: 183 PNGEVVLADEFSPDNCRLWDMETKDHMDKDVYRRQIGNLIDVYERVLARLK 233


>UniRef50_A4SE69 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=25
           Tax=Bacteria RepID=PUR7_PROVI
          Length = 238

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 105/232 (45%), Positives = 146/232 (62%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M K   L+ GKAK V+ T++ DL++ EF++D +A +  +      KG+VNN  +  + + 
Sbjct: 3   MNKTTLLHEGKAKKVFLTDDADLVIQEFKDDATAFNNKKKGSIADKGVVNNAISCRLFTM 62

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L E G+ T +   LSD + L ++LD++ VE VVRN AAGSLV+R G  EG  L  P+ + 
Sbjct: 63  LEEHGVNTHLVEKLSDRDMLCRRLDIIKVEVVVRNIAAGSLVRRYGFTEGTVLARPIVEF 122

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           +LK+D + DP++   +    G  + + L  +K      NDVLKK F D  L LVDFKLEF
Sbjct: 123 YLKDDDLDDPLMIAEHAVALGVATMDELEVLKSRAGAINDVLKKFFADRRLKLVDFKLEF 182

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G +KGE++LGDE SPD  R WD +T EKMDKDRFR  LGG+ +AY  V RR+
Sbjct: 183 GRHKGEILLGDEISPDTCRFWDLDTDEKMDKDRFRFDLGGVEDAYTEVQRRV 234


>UniRef50_C6I122 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6I122_9BACT
          Length = 242

 Score =  268 bits (685), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 94/228 (41%), Positives = 139/228 (60%), Gaps = 1/228 (0%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           +LY GKAK +Y+T +P +LV EF++D +A +  +   F  KG +N + +  +   LA  G
Sbjct: 8   KLYEGKAKILYATTDPRILVQEFKDDLTAFNAQKKGTFFGKGALNCQISAVLFELLASRG 67

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           +P     L +    L+ +L+MVP+E VVRNR AGSL KRLGI EG EL+ P+ + + K D
Sbjct: 68  VPVHFRSLETPRRMLIDRLEMVPLEVVVRNRVAGSLAKRLGIPEGEELSFPVVEWYYKRD 127

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK- 184
            + DPMVN  +       S   L +++E+  K N++L   + + G++LVD KLEFG    
Sbjct: 128 DLGDPMVNRDHIRVLKLASDAVLDKIREIALKTNEILLPFYRERGILLVDMKLEFGWNPA 187

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G++VLGDE   D SRLW+ ET  ++DKD FR  LG + E YE +  ++
Sbjct: 188 GDLVLGDEIDGDTSRLWEAETGVRLDKDLFRMDLGSVKEGYEKIYEKV 235


>UniRef50_Q1AXB9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacteria RepID=Q1AXB9_RUBXD
          Length = 237

 Score =  267 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 94/231 (40%), Positives = 138/231 (59%), Gaps = 2/231 (0%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  LY GKAK V+ T    +L+  ++++ +A +  +   +  KG  N   +  + + L 
Sbjct: 2   KRTLLYEGKAKQVFETGEEGVLLHRYKDEATAFNARKRGSWAGKGRANASISAAVFAYLE 61

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GIPT     + +     ++L M+PVE +VRN AAGSL + LG EEG  L  P+ +L  
Sbjct: 62  RRGIPTHFIEQVDEVTLKTRRLRMLPVEIIVRNLAAGSLARLLGYEEGRPLKAPVVELCY 121

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           KNDA+ DPM+N  +    G  + E L   +E   + N+ L+  F++ G++LVDFK+E G 
Sbjct: 122 KNDALGDPMLNWYHFRELGL-TDEELRACEEFGLRVNEALRPFFEERGMVLVDFKIEVGR 180

Query: 183 Y-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
              G +VL DE SPD  RLWDKET +++DKDRFR+ LGG+ EAYE V RR+
Sbjct: 181 DAGGSLVLADEISPDTCRLWDKETGQRLDKDRFRRDLGGVEEAYEEVLRRV 231


>UniRef50_A4FYT6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=11
           Tax=cellular organisms RepID=A4FYT6_METM5
          Length = 245

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 92/237 (38%), Positives = 141/237 (59%), Gaps = 2/237 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDL-LVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           +  +  +Y GKAK++Y  E  +  +++EFR+D +AG+GA+ +    KG +N   +  +  
Sbjct: 8   ITAKEPIYAGKAKSIYKIEENEKEVLVEFRDDITAGNGAKHDVKSGKGYLNTLISNELFK 67

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L +  +PT +   +     + K + ++P+E +VRN AAGSL K+   E+G  L   +  
Sbjct: 68  ILEQNNVPTHLIEYIEPNHMIAKNVKIIPLEVIVRNIAAGSLCKKYPFEQGQVLKTAVTQ 127

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              KND   DPM+N       G  ++E L  +K+L  K NDVLK  FD+ G+ILVDFK+E
Sbjct: 128 FDYKNDDYGDPMLNNEITIELGLATEEELVEIKKLALKVNDVLKGFFDEKGIILVDFKIE 187

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
            G    G++V+ DE SPD  RLWDKET + +DKD FR+ LG ++E Y+ VA+R+G  
Sbjct: 188 VGKTVDGDIVVADEISPDTMRLWDKETKDVLDKDVFRKDLGDVLEKYKTVAKRIGCL 244


>UniRef50_B5IMM2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Cyanobium sp. PCC 7001 RepID=B5IMM2_9CHRO
          Length = 255

 Score =  265 bits (678), Expect = 9e-70,   Method: Composition-based stats.
 Identities = 96/236 (40%), Positives = 141/236 (59%), Gaps = 9/236 (3%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L+ GKAK V++T+ PDL+ +EF++D +A +  +  Q   KG  N + +  +  +LA   
Sbjct: 9   LLHEGKAKRVHATDRPDLVAVEFKDDATAFNALKKAQLSGKGWHNCQISALLFEQLASQD 68

Query: 66  IPTQMERL----LSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
           IPT    L          LV+ + ++P+E V+RNRAAGSL +++ I  G  L PPL DL+
Sbjct: 69  IPTHYRGLAEAEHGGNWMLVRPVRIIPIEVVIRNRAAGSLCRQMPIHAGTPLEPPLLDLY 128

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
            K+D + DP++ E+  E    ++ E  A ++ L  + N  L K+FD  GLILVDFK+E G
Sbjct: 129 YKDDGLGDPLLTEARLERLALLTAEERADVERLAREVNTALVKVFDRVGLILVDFKIELG 188

Query: 182 LY-KGEVVLGDEFSPDGSRLWDKE----TLEKMDKDRFRQSLGGLIEAYEAVARRL 232
               G++V+ DE SPD  RLWD+         +DKDRFRQ LGG++EAY  V +RL
Sbjct: 189 YTADGQLVVADEISPDTCRLWDRAVEDVNERILDKDRFRQDLGGVVEAYGQVLKRL 244


>UniRef50_D2EKX6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Pediococcus acidilactici 7_4 RepID=D2EKX6_PEDAC
          Length = 244

 Score =  265 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 85/233 (36%), Positives = 132/233 (56%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+K   +  GKAK +Y+T+  D++ +E+ +  +  +G R +Q   KG +NN+ +  +   
Sbjct: 1   MKKTTLIKEGKAKRLYNTDEADVVWVEYLDQATTLNGKRRDQVIGKGALNNQIDCILFEM 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI T   + +SDTE L  K+D++P+E VVRN AAGS  ++  +    E + P+ + 
Sbjct: 61  LGAKGIHTDFIKKISDTEQLNYKVDVIPLEVVVRNAAAGSFQRKFAVPYLREFDQPIVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F K+D + DP +N +       +S      ++ L  + N +LK+ F  A L LVDFK+EF
Sbjct: 121 FYKSDELDDPFINTNQAVALKIISYAEGEILENLALQINRLLKEQFWQAHLQLVDFKVEF 180

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G    G+++L DE SPD  RL D  T   +DKD FR+  G L+  Y+ V RRL
Sbjct: 181 GKTADGKIMLADEISPDSCRLVDLTTKTSLDKDVFRKKTGDLVTVYQEVLRRL 233


>UniRef50_Q3AHS3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=21
           Tax=Bacteria RepID=PUR7_SYNSC
          Length = 250

 Score =  264 bits (676), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 91/234 (38%), Positives = 141/234 (60%), Gaps = 5/234 (2%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
              LY GKAK V+++ +PD +++EF+ND +A +  +  Q D KG +N + +  +   L  
Sbjct: 6   GELLYEGKAKRVFASTDPDRVLVEFKNDATAFNAQKKAQLDGKGRLNCQISARLFDLLER 65

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
            G+PT    L  +T  LV+++ ++P+E V+RN A GSL ++  I EG  + P L DL+ K
Sbjct: 66  EGVPTHYCGLAGETWMLVRRVRIIPLEVVLRNIATGSLCRQTPIAEGTAIEPALLDLYYK 125

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL- 182
           +D++ DP++ E+  +  G      L+ +++L  + N VL   FD+  L LVDFKLE GL 
Sbjct: 126 DDSLGDPLLTEARVQLLGVADTAQLSAIEQLARRVNAVLLPFFDELDLQLVDFKLELGLA 185

Query: 183 YKGEVVLGDEFSPDGSRLWDKETL----EKMDKDRFRQSLGGLIEAYEAVARRL 232
             G ++L DE SPD  RLWD+         +DKDRFR+ LGG++EAY  V +R+
Sbjct: 186 SDGTLLLADEISPDTCRLWDRRNSNAEDRILDKDRFRKDLGGVMEAYGEVLKRV 239


>UniRef50_Q7V0C7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Prochlorococcus marinus RepID=PUR7_PROMP
          Length = 242

 Score =  263 bits (674), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 92/237 (38%), Positives = 138/237 (58%), Gaps = 5/237 (2%)

Query: 2   QKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL 61
            K   +Y GKAK +++ E+ D +++EF++D +A +  +  +F+ KG +N   +  I   L
Sbjct: 3   SKLKFIYEGKAKKIFAYEDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFEFL 62

Query: 62  AEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
            +  IPT    L ++   + +K+ ++P+E V+RN A GSL K+  I+ G  L  PL D +
Sbjct: 63  IKNNIPTHYIGLKNNNSMIAQKIKIIPLEVVLRNTAYGSLCKQTTIKPGTVLESPLIDFY 122

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
           LKND ++DP++ +        V +E L  +  +T K N +LKK F +  L LVDFKLEFG
Sbjct: 123 LKNDTLNDPLLTKDRINLLKIVDEEELDFISNMTLKINKLLKKFFYNIKLDLVDFKLEFG 182

Query: 182 L-YKGEVVLGDEFSPDGSRLWDKETLE----KMDKDRFRQSLGGLIEAYEAVARRLG 233
               G++VLGDE SPD  RLWD          +DKDRFR  LGG IEAY  + +R+ 
Sbjct: 183 YNSNGQIVLGDEISPDNCRLWDLNQKNGMIVSLDKDRFRNDLGGFIEAYSEINKRIN 239


>UniRef50_O26272 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Euryarchaeota RepID=PUR7_METTH
          Length = 248

 Score =  263 bits (674), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 97/228 (42%), Positives = 135/228 (59%), Gaps = 1/228 (0%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            LY GKAK V  T++P+++ + FR+D +AGDG + +  + KG  N+  +  I   L EAG
Sbjct: 8   PLYSGKAKDVLLTDDPEIVAVRFRDDITAGDGEKKDTLEMKGYYNSVISAKIFEVLEEAG 67

Query: 66  IPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKND 125
           +PTQ   L      L +KL+M+P+E + RN AAGS+V+R    EG E  PPL  +  K+D
Sbjct: 68  VPTQYLELREPGCILARKLEMIPIEVITRNIAAGSIVRRFPFTEGQEFVPPLIQMDYKSD 127

Query: 126 AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-K 184
              DPM+N+      G  +++ L  ++ +T   N VL+      GLIL DFKLEFG    
Sbjct: 128 EHGDPMLNDDIILALGIATRDELEEIRRITLHINSVLRDFLKSRGLILPDFKLEFGRDSS 187

Query: 185 GEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G + LGDE SPD  RLWD ET E +DKD FR+   G++ AY  VAR +
Sbjct: 188 GRIRLGDEVSPDTCRLWDMETGEPLDKDIFRRGEEGVVGAYRRVARMI 235


>UniRef50_A9BIH1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Petrotoga mobilis SJ95 RepID=A9BIH1_PETMO
          Length = 238

 Score =  260 bits (664), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 83/235 (35%), Positives = 129/235 (54%), Gaps = 3/235 (1%)

Query: 2   QKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL 61
           +    LY GKAK VY  +    L++EF++D +A +G + +Q   KG +N + + F    L
Sbjct: 5   KNFELLYEGKAKKVYKFDEK-KLLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFFEML 63

Query: 62  AEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLF 121
              GI T       +   + K  D++P+E ++RN  AG   KR G+++G+  + PL +  
Sbjct: 64  NNQGINTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLVEFS 123

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
           LKND + DPM+ +         ++  L  +  ++ K N++L       G+ILVDFKLEFG
Sbjct: 124 LKNDELGDPMIAKDAILLLKITTENVLDEIASISKKVNNILSDYLKSKGIILVDFKLEFG 183

Query: 182 LY--KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           +     +V L DE SPD  R WD  T+E +DKD +R++ G LI AYE +  RL +
Sbjct: 184 ISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI 238


>UniRef50_D0JBF3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Blattabacterium RepID=D0JBF3_BLASB
          Length = 242

 Score =  256 bits (654), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 90/237 (37%), Positives = 147/237 (62%), Gaps = 4/237 (1%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  L  GK K +Y+T N   +++ +++  +A DG++ +    KG++NN+ +  I   + 
Sbjct: 6   KKNLLSEGKTKKIYTTNNSLEVLIHYKDSITALDGSKNQFLQDKGILNNEISTLIFKFIN 65

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GI T   R +++ E L  K+D++P+E VVRN  AGS+ KRL I+EGI L  P+F++F 
Sbjct: 66  SCGIKTHFIRKINNREQLCYKVDIIPLEFVVRNIVAGSMSKRLNIQEGIRLLNPIFEIFY 125

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           KND + DP++N+ +    G +S E +  +  +    N++LKK F D  +ILVDFK+EFG 
Sbjct: 126 KNDKLKDPLINDHHAVFLGIISYEEINAIYRIVSNVNNILKKYFLDKNIILVDFKIEFGK 185

Query: 183 -YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSL---GGLIEAYEAVARRLGVQ 235
             + +++L DE SPD  R WDK+T++K+DKD FR  L     +++ Y  + +RL V+
Sbjct: 186 NDQNDILLSDEISPDTCRFWDKKTMKKLDKDPFRIGLKEKEEVLDIYMEILKRLNVR 242


>UniRef50_P22234 Phosphoribosylaminoimidazole carboxylase n=88 Tax=Metazoa
           RepID=PUR6_HUMAN
          Length = 425

 Score =  253 bits (648), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 76/251 (30%), Positives = 121/251 (48%), Gaps = 18/251 (7%)

Query: 4   QAELYRGKAKTVYST-ENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
             +LY GK K VY   ++P  ++L+ ++  +AG+ AR    + K  ++NK    I   L 
Sbjct: 10  GKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQ 69

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFDLF 121
           EAGI T   R   +T  +  + +M+P+E V R  A GS +KR  G++EG +  PP  +LF
Sbjct: 70  EAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELF 129

Query: 122 LKNDAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLILVD 175
            K+DA +DP  +E              + +  +  M   T    ++L+K +      LVD
Sbjct: 130 FKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVD 189

Query: 176 FKLEFGLY--KGEVVLGDEFSPDGSRLWDKETL-EKMDKDRFRQ-------SLGGLIEAY 225
            K+EFG+     E+VL D    D  RLW      ++ DK  +R         L  + + +
Sbjct: 190 MKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNF 249

Query: 226 EAVARRLGVQL 236
           E VA R+ + L
Sbjct: 250 EWVAERVELLL 260


>UniRef50_B8GCM2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Chloroflexi (class) RepID=PUR7_CHLAD
          Length = 250

 Score =  252 bits (645), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 105/237 (44%), Gaps = 7/237 (2%)

Query: 1   MQKQAELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M+    L  GK K VY+   +PDL +L  ++  +AGDGAR      KG +  +    +  
Sbjct: 1   MELGHVLSEGKTKIVYAHPTDPDLAILFHKDGITAGDGARRHVIAGKGALAGQTTANVFR 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L  AGI T           +V++  M+P+E V+R   AGS ++R     G   +PPL +
Sbjct: 61  FLNRAGIATHFIEAPEPKLTVVRRCVMIPLEVVMRRLPAGSYLRRYPEAAGQRFDPPLVE 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
            FLK+DA HDP +        G  +   + +M     +    L+  +    + LVD K+E
Sbjct: 121 FFLKDDARHDPQITPDEIVAQGIATPAEVEQMTMTGQQVFTTLEAAWAKLDVTLVDLKIE 180

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKET-LEKMDKDRFRQ----SLGGLIEAYEAVAR 230
           FG    G +++ D    D  R+W        +DK  +R         L + Y   A+
Sbjct: 181 FGRAGDGSLLVADVIDNDSWRIWPGGDPNRMLDKQVYRNAQVVDEDVLADVYARYAQ 237


>UniRef50_B8D414 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Desulfurococcus kamchatkensis 1221n
           RepID=B8D414_DESK1
          Length = 253

 Score =  249 bits (637), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 90/238 (37%), Positives = 141/238 (59%), Gaps = 6/238 (2%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +   LY GK K VYS + P+LLVLEF++D +A DG   +    KG++N + + ++   + 
Sbjct: 12  ELKLLYEGKTKRVYS-KTPELLVLEFKDDVTAMDGLVKKTMPGKGVINARLSAYLFKHIE 70

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFDLF 121
           + GI T +     D    V++L+M+P+E +VRN A GSL+KR+ + ++  ELNPPL +  
Sbjct: 71  KQGIETHLVEYNGDRFLTVRRLEMLPIEVIVRNYAYGSLLKRMPLYKKMQELNPPLVEFH 130

Query: 122 LKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFG 181
            K+D++HDP++        G ++   L  + E T K N+VL +LF  AGL LVDFK+E+G
Sbjct: 131 YKDDSLHDPLITPEDITYTGLLTSGELRWLIEATIKINNVLSELFSGAGLKLVDFKVEYG 190

Query: 182 LY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQ--SLGGLIEAYEAVARRLGVQL 236
               G ++LGDE + D  R+ D +    +DK+ FR+   +  L  AY  +  RLGV +
Sbjct: 191 RNRNGRLILGDELTGDSIRVLD-DKGNHLDKEVFRKTGDIEALRTAYIELCNRLGVNV 247


>UniRef50_Q03Y92 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=Leuconostocaceae RepID=Q03Y92_LEUMM
          Length = 249

 Score =  246 bits (628), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 76/233 (32%), Positives = 128/233 (54%), Gaps = 1/233 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           + +    Y+GKAK VY T+NP +L + + +  +A +G   E    KG +N+  ++ +   
Sbjct: 12  VTRGELKYQGKAKQVYFTDNPTILWVHYMDQATALNGKVHENIPEKGQLNSAISHILFEH 71

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L   GI       +S+T+ L   LD++P+E V RN A+G  V +       +L P + + 
Sbjct: 72  LTRQGIENHYLSSVSETDELDLALDILPIEVVTRNYASGHFVSKFNATPMQKLTPVVQEF 131

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           + K+D + DP +N+S     G+ +   L +++    + N  L ++FD+  + LVDFKLE+
Sbjct: 132 YYKSDELDDPFMNDSQILALGFATLSELTKLRAYAQEVNQALTEIFDEININLVDFKLEY 191

Query: 181 GLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
           G   +G+++L DE SPD  RL D++T + +DKD FR+  G +   Y  V  RL
Sbjct: 192 GRDSEGKLILADELSPDNMRLVDQKTGKSLDKDVFRKHAGDVTVGYRDVLSRL 244


>UniRef50_C2U7A6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Bacillus cereus RepID=C2U7A6_BACCE
          Length = 239

 Score =  245 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 83/234 (35%), Positives = 129/234 (55%), Gaps = 4/234 (1%)

Query: 1   MQKQAELYR-GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           M K   LY  GK+K++Y  E  D +++ F +  S+    +  +    G++  +F+  I  
Sbjct: 1   MTKNGLLYTCGKSKSMYYGEENDSIIMHFLDSVSSYTQNKNARIIGTGILRCEFSSHIFE 60

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L + G+P      +      V KLDM+ +E + RN AAGS+V+   I+ G   N P+  
Sbjct: 61  LLHKKGVPNHYISNIGMGRMKVNKLDMIKLEIIPRNIAAGSIVRNYPIQYGQVFNQPILK 120

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
           L LK    +DPM+N  Y    G  +K  +  ++E+ ++ N +LK    + G+ LVDFK E
Sbjct: 121 LDLKY--SNDPMMNSDYIVAMGIATKREIEVIREIAFELNAILKDFLLERGVKLVDFKFE 178

Query: 180 FGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRL 232
            G    G++V+GDE SPDG RLWD ET + +DKD FR + G L+ AYE + +R+
Sbjct: 179 MGRNAAGDLVIGDEISPDGMRLWDIETNQSLDKDVFRYNKGDLVHAYEEILKRI 232


>UniRef50_A8MCJ8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Caldivirga maquilingensis IC-167 RepID=PUR7_CALMQ
          Length = 241

 Score =  243 bits (620), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 88/240 (36%), Positives = 130/240 (54%), Gaps = 7/240 (2%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           + +   +Y GKAK VY   N + LV+EF+++ +A DGAR E    KG +      F MS 
Sbjct: 3   LGEGKLIYEGKAKRVYLINNEE-LVMEFKDEVTALDGARKEYAPGKGKLAASQTAFFMSY 61

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGI-EEGIELNPPLFD 119
           L E+G+ T       D    V++L M+PVE +VRN A GS ++R+ + +   +   PL +
Sbjct: 62  LNESGVRTHFINWDGDRRIHVRRLRMIPVEVIVRNYAYGSFIRRMPLIKPLTKFTTPLVE 121

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
             LKND +HDP++        G  S E +  ++ ++ K N +L +L    GL LVDFKLE
Sbjct: 122 FHLKNDELHDPLILIEDIIEAGLTSMEQVMEIRSVSLKVNHLLSELLGKYGLTLVDFKLE 181

Query: 180 FGL-YKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQS--LGGLIEAYEAVARRLGVQL 236
           FG+   G +VL DE S D  R+      + +DK+ FR    +  LIEAY  +   LG+ L
Sbjct: 182 FGVNSNGALVLADELSGDTMRV--LMNGKHLDKELFRMGGSVKELIEAYSRLNSILGLGL 239


>UniRef50_UPI00006A4774 PREDICTED: similar to phosphoribosylaminoimidazole carboxylase,
           phosphoribosylaminoribosylaminoimidazole
           succinocarboxamide synthetase n=1 Tax=Ciona intestinalis
           RepID=UPI00006A4774
          Length = 471

 Score =  243 bits (620), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 70/250 (28%), Positives = 116/250 (46%), Gaps = 19/250 (7%)

Query: 2   QKQAELYRGKAKTVYS--TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
                   GK K VY   T+ P   ++  ++  +AGDGA+    + K  +++  N  +M 
Sbjct: 51  TLGKMFCEGKTKVVYEINTKTPGRCLIVSKDIITAGDGAKRNVMEGKAELSSATNAAVMQ 110

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-GIEEGIELNPPLF 118
            L + G+ T   + ++    L  K DM+P+E V R  A GS ++R  G++EG   +PP  
Sbjct: 111 MLNDFGLKTAFIKGVNKKSFLAWKCDMIPIEWVARRVATGSFIRRHVGVKEGYRFSPPKL 170

Query: 119 DLFLKNDAMHDPMVNESYCETFGW------VSKENLARMKELTYKANDVLKKLFDDAGLI 172
           + F K+D  HDP  +    E          V+ + +  M+++T    +VL+K +    + 
Sbjct: 171 ETFYKDDENHDPQWSREVLEEAKLKCGKIVVTPDLIDIMEKMTITIFEVLEKAWKSKNVS 230

Query: 173 LVDFKLEFGL--YKGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLI 222
           L+D K+EFG+     E+VL D    D  R+W       M DK  +R         +  L 
Sbjct: 231 LIDMKIEFGVRQDTNEIVLADVIDNDSWRIWPSGDKRLMKDKQVYRNLKEVTNGDMQNLK 290

Query: 223 EAYEAVARRL 232
           E Y  V+ +L
Sbjct: 291 ENYTWVSNQL 300


>UniRef50_Q47KH4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=226
           Tax=Bacteria RepID=PUR7_THEFY
          Length = 307

 Score =  241 bits (616), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 63/257 (24%), Positives = 106/257 (41%), Gaps = 35/257 (13%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L+ GK + +Y+TE+ + LV+   +  SA D     +   KG +  + + +   +L++ 
Sbjct: 17  THLHTGKVRDLYATESGE-LVMVASDRVSAFDWVLPTEIPDKGRLLTQLSLWWFDQLSDI 75

Query: 65  GIPTQMERLLSD---------TECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
            I   +                  + ++LDMVPVECV R    GS +             
Sbjct: 76  -IDNHVISDTPPPGAPDDWAGRTLVCRRLDMVPVECVARGYLTGSGLAEYTATGAVCGVR 134

Query: 106 ---GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDV 161
              G+ +G  L+PP+F    K +   HD  V+                R++E+T    + 
Sbjct: 135 LPEGLVDGSRLDPPIFTPATKAEVGEHDENVSLETVAERH--GPALAERLREVTLALYER 192

Query: 162 LKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE------KMDKDR 213
            +++ ++ G++L D K EFG    G +VL DE  +PD SR W KE           DK  
Sbjct: 193 GREIAEERGILLADTKFEFGWDSDGSLVLADEVLTPDSSRFWPKEEWRPGRPQPSFDKQI 252

Query: 214 FRQSLGGLIEAYEAVAR 230
            R  L      ++  + 
Sbjct: 253 IRDWLSSAESGWDRTSE 269


>UniRef50_Q8D2M4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=46
           Tax=Gammaproteobacteria RepID=PUR7_WIGBR
          Length = 240

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 118/238 (49%), Positives = 176/238 (73%), Gaps = 1/238 (0%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           ++K+ ++Y+GK+K +YST N D+L+L+F+ D S  +G  I++FD K ++NNKFNY+IM+K
Sbjct: 3   IKKKNKIYQGKSKIIYSTNNSDVLILKFKKDMSRLNGKYIKKFDNKDIINNKFNYYIMNK 62

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           ++   I T +  LLSD + +VKKL M+P+E VVRN A GSL+KR  I+E   +NPP+ + 
Sbjct: 63  ISSFNIKTHILSLLSDNQVIVKKLKMIPIEFVVRNYAYGSLLKRFLIKERSFINPPILEF 122

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           F KND + DPM+NE +C +F  +S+ ++ ++K++ YK N++LK +F  A LILVDFKLEF
Sbjct: 123 FFKNDGLKDPMINEYHCISFNLISENHIKKIKKILYKINNILKDIFYKAELILVDFKLEF 182

Query: 181 GLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSL-GGLIEAYEAVARRLGVQLD 237
           GL+ G++ LGDEFS D SR+WDK + +KMDKD FR+ L   +IE+Y+ VA R+G  +D
Sbjct: 183 GLFNGDLFLGDEFSLDNSRVWDKNSFKKMDKDIFREQLNENVIESYKEVANRIGCLID 240


>UniRef50_C6XGE3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Alphaproteobacteria RepID=C6XGE3_LIBAP
          Length = 255

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 82/238 (34%), Positives = 129/238 (54%), Gaps = 4/238 (1%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M+ +  +Y  K K +Y    P  L+  F++D    +  R    + KG++NN+ + ++ ++
Sbjct: 1   MRPRNPVYEEKTKIIYEGLEPGTLIQFFKDDNLLENNPRCATLNGKGVLNNRISEYMFTQ 60

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDL 120
           L + GIP    R ++  E LV+ ++M+P+   VRN AAGSL KRL I EG+ L   L + 
Sbjct: 61  LGKIGIPHYFIRRINMREQLVRDVEMIPLLITVRNTAAGSLAKRLNIPEGLSLPRSLVEF 120

Query: 121 FLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEF 180
           +   D+    +V+E +   F W ++  +  M  L+ + ND +  LF    + LVDF+++ 
Sbjct: 121 YYLPDSSEKTLVSEEHITAFNWANQSEVEEMTALSIRINDFMTGLFLGINIQLVDFRIKC 180

Query: 181 G--LYKG--EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
           G  L      +VL DE  PD  RLWD    E+ DK RF +S   L+E Y  VARRLG+
Sbjct: 181 GRLLDDDILRIVLADEIFPDCCRLWDLSKKEECDKKRFSKSNDQLLEGYSEVARRLGI 238


>UniRef50_A8ZVI6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=15
           Tax=Bacteria RepID=PUR7_DESOH
          Length = 293

 Score =  238 bits (609), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 60/253 (23%), Positives = 98/253 (38%), Gaps = 41/253 (16%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L RGK + VY     D L++   +  SA D    +    KG +  + + F   ++ + 
Sbjct: 14  NLLKRGKVRDVYDF--GDRLLIVATDRLSAFDVVMPDPIPGKGEILTQISLFWFDQVKDI 71

Query: 65  GIPTQME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
            +   +                  L+    LV K + + +ECVVR   +GS  K      
Sbjct: 72  -VRNHLISSDVNDYPEACRPYAETLAGRSMLVTKTEPLAIECVVRGYLSGSGWKSYQKDR 130

Query: 106 ---------GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMKELT 155
                    G+ E   L  P+F    K +A  HD  ++           +E   + ++L+
Sbjct: 131 TVCGISLPDGLRESDRLPEPIFTPSTKAEAGQHDINISFDE--AANIAGRETTEKARDLS 188

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETL------EK 208
                   ++ D  G+I+ D K EFG   GE++L DE  +PD SR W ++        + 
Sbjct: 189 LAIYRRGVEVADARGIIIADTKFEFGFVDGELILIDEVLTPDSSRFWPRDGYAPGGPQQS 248

Query: 209 MDKDRFRQSLGGL 221
            DK   R  L  L
Sbjct: 249 FDKQYVRDYLLSL 261


>UniRef50_A1VU36 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=19
           Tax=Bacteria RepID=PUR7_POLNA
          Length = 305

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 66/260 (25%), Positives = 96/260 (36%), Gaps = 43/260 (16%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           +     L RGK +  Y+  N D L++   +  SA D    E    KG +  +   F   K
Sbjct: 13  LTSLPLLARGKVRDNYAVGN-DRLLMVASDRLSAFDVILGEPIPGKGALLTQMALFWFDK 71

Query: 61  LAEAGIPTQM-------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
           L     P  +                ++    LVK+L  +PVE VVR   AGS       
Sbjct: 72  LGSIC-PNHLTGEAPESVVTAAEIPQVAGRSMLVKRLKPIPVEAVVRGYLAGSGWVEYQQ 130

Query: 106 -----------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKE 153
                      G++   +L  P+F    K +   HD  ++         V  E  A++K 
Sbjct: 131 SQSVCGVPLPAGLKNASKLPEPIFTPAAKAEVGEHDENISYEQVV--KVVGPELAAQIKT 188

Query: 154 LTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE---- 207
           L+    +         G+I+ D K EFGL + G + L DE  +PD SR W  E  E    
Sbjct: 189 LSIAIYETAAAFALTKGIIIADTKFEFGLDENGTLTLMDEVLTPDSSRYWPVEGYEAAFA 248

Query: 208 ------KMDKDRFRQSLGGL 221
                   DK   R  L  +
Sbjct: 249 AGQNPPSYDKQFVRDWLEAV 268


>UniRef50_Q5X4M9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=33
           Tax=cellular organisms RepID=PUR7_LEGPA
          Length = 312

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 60/250 (24%), Positives = 95/250 (38%), Gaps = 35/250 (14%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y+GK +  Y     D L+L   +  SA D         KG V N  + +         +P
Sbjct: 16  YKGKVRDTYDL--GDQLILVTTDRQSAFDRCLAA-VPYKGQVLNLTSVWWFKNTQSI-VP 71

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGS----LVKRL--------------GIEE 109
             +  +      + KK  + P+E VVR   +GS    L  +               G+ +
Sbjct: 72  NHLIAVPDPNVAIAKKCKIFPIEFVVRGYISGSTSTSLWTQYQKGVREYCGITFPDGLRK 131

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +L  P+     K + +HD  ++       GW+++E+         K      ++    
Sbjct: 132 NQKLESPVITPTTK-ETLHDRPISPHEIVAEGWMTQEDWDETSSYALKLFQHGMEVAQQH 190

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQS 217
           GLILVD K EFG   +G +VL DE  +PD SR W               E +DK+  R  
Sbjct: 191 GLILVDTKYEFGRDAEGRIVLVDEIHTPDSSRYWLFNGYQERFDAGKEPENIDKEFLRLW 250

Query: 218 LGGLIEAYEA 227
                + Y+ 
Sbjct: 251 FVDHCDPYKD 260


>UniRef50_D0MIB5 Phosphoribosylaminoimidazolesuccinocarboxamidesy nthase n=18
           Tax=Bacteria RepID=D0MIB5_RHOM4
          Length = 328

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 57/240 (23%), Positives = 95/240 (39%), Gaps = 29/240 (12%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           YRGK + VY+ +    LV+   +  SA D    +    KG V N+   +     A+  +P
Sbjct: 27  YRGKVRDVYTVD--GHLVIVTTDRISAFDHILRQTIPFKGQVLNQLAAYFFRHTADL-VP 83

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEGIEL 113
             +E +      + ++   +P+E VVR   AG   +                G+ +   L
Sbjct: 84  NHVEAVPDPNVTVARRCRPIPIEFVVRGYLAGHAWRVYRSGRRELCGKKLPEGLVQNARL 143

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
             P+     K    HD  ++       G +  E   R++ +T        ++    GLIL
Sbjct: 144 PEPILTPATKAKEGHDEDISREEIIARGLLDAETFDRIEVMTLALYRRGAEMAARRGLIL 203

Query: 174 VDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQSLGGL 221
           VD K EFG+   G + L DE  +PD SR +  +  E          ++ K+  R+ L   
Sbjct: 204 VDTKYEFGIDDEGMIRLIDEVHTPDSSRYFYADEYEERLRKGLPQRQLSKEFVREWLMEH 263


>UniRef50_Q4J8G0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=Sulfolobaceae RepID=PUR7_SULAC
          Length = 235

 Score =  238 bits (607), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 81/229 (35%), Positives = 132/229 (57%), Gaps = 4/229 (1%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             +  GK K VY   +P+  +L F++  +AGDGAR ++   KG +N + +      L + 
Sbjct: 4   KRVAEGKTKIVYEF-DPEHYLLRFKDSITAGDGARKDELPGKGTLNAQTSALFFRLLEKN 62

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKN 124
            I T    +  +   +V KL M+PVE V+RN A GS+VKRL I+EG   +PP+ + FLK+
Sbjct: 63  DIRTHYVGMYDEKTMIVTKLKMIPVEVVLRNIATGSIVKRLPIKEGEVFDPPIVEFFLKD 122

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY- 183
           D  HDP++N S+ + F  ++++    ++E+  K N V+K    + GL+L D KLEFG   
Sbjct: 123 DLRHDPLLNYSHLQYFNLLTRKEAEIVEEVIVKVNAVMKNFLKERGLVLYDLKLEFGKDK 182

Query: 184 KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQS--LGGLIEAYEAVAR 230
              +++GDE + D  R+ D++T + +DKD +R+   L  + +AYE    
Sbjct: 183 DNNLIVGDEITLDSMRVRDEKTNKILDKDLYRKGESLEVVKKAYEDFFN 231


>UniRef50_A3MXE4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=5
           Tax=Thermoproteaceae RepID=PUR7_PYRCJ
          Length = 240

 Score =  238 bits (607), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 72/233 (30%), Positives = 116/233 (49%), Gaps = 7/233 (3%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M     +Y GKAK VY T     L++ F+++ +AGDGAR ++   KG +  + +  +   
Sbjct: 1   MGFMELVYEGKAKAVYKTREG--LLMVFKDEVTAGDGARRDKAPGKGALAAETSTLLFQY 58

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG-IEEGIELNPPLFD 119
           L   G+ T     +     LVK   + P+E +VR +A GS +KR+   +       P+ +
Sbjct: 59  LQGRGVTTHYLMFVPPNAILVKPAQVPPLEVIVRFKAYGSYLKRMPKAKPLTPFAKPIVE 118

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K+D++HDP++ E      G ++   LA +K++  +A   L++L+       VD K E
Sbjct: 119 FHYKDDSLHDPLILEDDVVEAGLLTAGELAAVKDMALRAASALRELYASVDCDFVDVKFE 178

Query: 180 FGLYKGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQ--SLGGLIEAYEAVAR 230
           FG   GE+VL DE S D  RL      E  DK+ +R+     GL+E Y  +  
Sbjct: 179 FGRVGGELVLVDEVSGDTFRL--LCGGEHFDKEYYRKTGDAVGLVERYAKLLE 229


>UniRef50_B4Q3U0 GD23841 n=2 Tax=melanogaster subgroup RepID=B4Q3U0_DROSI
          Length = 413

 Score =  237 bits (606), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 66/252 (26%), Positives = 105/252 (41%), Gaps = 17/252 (6%)

Query: 2   QKQAELYRGKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           Q    L  GK K VY   + P L +L  ++  +A DG +  +   K  ++N  N  +   
Sbjct: 10  QLGKILIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLKAHELQGKAAISNTTNGLVFRL 69

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-RLGIEEGIELNPPLFD 119
           L EAGI T       D   + +K  MVP+E V R  A GS +K    + EG    PP  +
Sbjct: 70  LNEAGIRTAYVDQCGDNAFIARKCKMVPIEWVTRRLATGSFIKINPEVPEGYRFAPPKQE 129

Query: 120 LFLKNDAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
              K+D+ HDP+  +    +         +  + +  M+  +    +VL++ +      L
Sbjct: 130 TCFKDDSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRHTSLVVFEVLERAWKTRNCAL 189

Query: 174 VDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIEA 224
           VD K+EFG+   G ++L D    D  R+W       M DK  +          L  +   
Sbjct: 190 VDMKVEFGVDEDGNILLADIIDSDTWRIWPAGDKRLMVDKTVYINLDTVTDGDLNTVKRN 249

Query: 225 YEAVARRLGVQL 236
           Y  V  +L   +
Sbjct: 250 YFWVIEQLSSIV 261


>UniRef50_A9VBB9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Monosiga brevicollis RepID=A9VBB9_MONBE
          Length = 368

 Score =  237 bits (605), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 70/252 (27%), Positives = 113/252 (44%), Gaps = 24/252 (9%)

Query: 4   QAELYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
              +  GK K V+    N D ++L  ++  +AGDGAR  +   K  V N     I   L 
Sbjct: 5   GKTIVEGKTKVVHQHARNFDQVILVSKDRITAGDGARAHEISGKAKVANDTTCTIFEFLN 64

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR----LGIEEGIELNPPLF 118
             GIP+       D   + KK+ M+P+ECV R  A GS ++R      + E      P  
Sbjct: 65  SVGIPSHFVARSGDM-MVAKKVHMIPIECVARRVAYGSYLRRFKTPFPVTEAYRFPTPCL 123

Query: 119 DLFLKNDAMHDPMVNESYCETFGW---------VSKENLARMKELTYKANDVLKKLFDDA 169
           + F K+DA HDP V +    +            ++ + + +M+  T    + L++ +   
Sbjct: 124 EFFYKDDANHDPQVTKEQLLSNPLLLDEAKQLRLTPKYVEQMELWTRAVFETLERAWAVQ 183

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGG 220
           G  LVD K+EFG+  +G ++L D    D  R+W +     M DK  +R+        L  
Sbjct: 184 GCTLVDMKIEFGIDMQGRLILADVIDNDAWRVWPQGDRRLMKDKQFYRELKTVTDADLTE 243

Query: 221 LIEAYEAVARRL 232
           +++ YE VA  +
Sbjct: 244 VLKKYEWVADAV 255


>UniRef50_Q9VK80 CG17024 n=4 Tax=melanogaster group RepID=Q9VK80_DROME
          Length = 395

 Score =  234 bits (598), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 65/248 (26%), Positives = 102/248 (41%), Gaps = 17/248 (6%)

Query: 2   QKQAELYRGKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           Q    L  GK K VY   + P L +L  ++  +A DG    +   K  ++N  N  +   
Sbjct: 10  QLGKILIEGKTKKVYDLPDHPGLCLLLSKDRITAFDGLMAHELQGKAAISNTTNGLVFRL 69

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVK-RLGIEEGIELNPPLFD 119
           L EAGI T       D   + +K  MV +E V R  A GS +K    + EG    PP  +
Sbjct: 70  LNEAGIRTAYVDQCGDNAFIARKCQMVHIEWVTRRLATGSFIKLNPEVPEGYRFAPPKQE 129

Query: 120 LFLKNDAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
              K+D+ HDP+  +    +         +  + +  M+  +    +VL++ +      L
Sbjct: 130 TCFKDDSSHDPLWCDEQILSSNFECNGLIIGADEVQIMRRTSLVVFEVLERAWKTKNCAL 189

Query: 174 VDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIEA 224
           VD K+EFG+   G ++L D    D  R+W       M DK  +          L  +   
Sbjct: 190 VDMKVEFGVDEDGNILLADIIDSDTWRIWPAGDKRLMVDKTVYINLDTVTDSDLNTVKRN 249

Query: 225 YEAVARRL 232
           Y  V  +L
Sbjct: 250 YSWVIEQL 257


>UniRef50_B1LCA5 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=9
           Tax=Thermotogaceae RepID=PUR7_THESQ
          Length = 230

 Score =  234 bits (597), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 89/224 (39%), Positives = 119/224 (53%), Gaps = 5/224 (2%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK K V  T   D  +LEF++D +AGDG + +    KG +  +    +M  L+E  I 
Sbjct: 3   YEGKTKIVKVT--GDYALLEFKDDITAGDGLKHDVLTGKGSICAETTAILMKYLSEKDIK 60

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLKNDAM 127
           T +   +      V  L M P+E VVR + AGS V+R G  EG +L  PL + F+K+D  
Sbjct: 61  THLVEYIPPRTLKVIPLKMFPLEVVVRLKKAGSFVRRYGGAEGEDLPVPLVEFFIKDDER 120

Query: 128 HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGE 186
           HDPMV   + E  G  +K+   +MKE   K    LK+ F+ A   L D K EFGL   G 
Sbjct: 121 HDPMVCVDHLEILGIATKKQAEKMKEAAVKITLALKEFFERANFELWDIKYEFGLDKDGN 180

Query: 187 VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVAR 230
           VVLGDE SPD  RL +K   E  DKD +R+ LG  ++ Y  V  
Sbjct: 181 VVLGDEISPDTFRLRNKG--EIFDKDVYRRDLGDPLKKYREVLE 222


>UniRef50_A6LDF8 Phosphoribosylamidoimidazole-succinocarboxamide synthase n=19
           Tax=Bacteroidetes RepID=A6LDF8_PARD8
          Length = 316

 Score =  233 bits (595), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 58/242 (23%), Positives = 96/242 (39%), Gaps = 28/242 (11%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +Q  +Y GK + VY+  + ++LV+   +  SA D    E    KG + N+     +    
Sbjct: 14  RQKSVYHGKVRDVYNIND-EVLVMVATDRISAFDVILPEGIPYKGQMLNQIAAKFLDATT 72

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIE 108
           +   P            +  +    PVE +VR    GS  +                G+ 
Sbjct: 73  DIC-PNWKMATPDPMVTVGVQCQGFPVEMIVRGYLCGSAWRAYKSGVREICGVKLPEGMR 131

Query: 109 EGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
           E      P+     K +   HD  +++      G VSKE+   +++ T        ++  
Sbjct: 132 ENQRFPEPIITPTTKAEIGEHDQDISKEEILAKGLVSKEDYEVLEKYTMALFKRGTEIAK 191

Query: 168 DAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQ 216
           + GLILVD K EFG   G++ L DE  +PD SR +  E  E          ++ K+  R+
Sbjct: 192 ERGLILVDTKYEFGHRDGKIYLIDEIHTPDSSRYFYSEGYEDRFAKGEPQKQLSKEFVRE 251

Query: 217 SL 218
            L
Sbjct: 252 WL 253


>UniRef50_C4FB69 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Collinsella intestinalis DSM 13280
           RepID=C4FB69_9ACTN
          Length = 322

 Score =  233 bits (594), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 63/248 (25%), Positives = 103/248 (41%), Gaps = 41/248 (16%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y  +  D L++   +  SA D    ++   KG V ++ + F   KLA+  +P 
Sbjct: 25  QGKVRDIY--DAGDSLLMVASDRISAFDYILPDEIPYKGEVLSRISAFWFEKLADV-VPN 81

Query: 69  QME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-------- 105
            +                  LS    LV+K + + +ECVVR    GS+ +          
Sbjct: 82  HLVSMDPRDFPAEFLPYEEYLSGRAMLVRKAEPIKIECVVRGYLTGSIKEAYDATGEVDG 141

Query: 106 -----GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMKELTYKAN 159
                G+ E   L  PLF    K D   HD  ++   C     + ++  +++++L+    
Sbjct: 142 IALPAGLVEASPLPEPLFTPSTKADVGDHDENISYERCVE--LIGEDLASQIRDLSISLY 199

Query: 160 DVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEK------MDKD 212
               +     G+I+ D K EFG+  G V L DE  +PD SR WD  + E+       DK 
Sbjct: 200 TEAARYARTRGIIIADTKFEFGIIDGRVTLIDECLTPDSSRFWDAASYEEGKVQPGYDKQ 259

Query: 213 RFRQSLGG 220
             R  L  
Sbjct: 260 YVRDWLKD 267


>UniRef50_B6YRK7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=11
           Tax=Bacteroidales RepID=PUR7_AZOPC
          Length = 323

 Score =  232 bits (592), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 58/240 (24%), Positives = 93/240 (38%), Gaps = 27/240 (11%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           Q  LY GK + VY+    D+LV+   +  SA D         KG V N+     +   ++
Sbjct: 14  QTHLYHGKVRDVYTVG-SDMLVIIATDRISAFDVVLSRGIPYKGQVLNQIAAKFLDSTSD 72

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEE 109
             +P            +    +   VE V+R    GS  ++               G++E
Sbjct: 73  I-LPNWKLAEPDPMVTIGLLCEPFKVEMVIRGYLTGSAWRKYKEGERTLCAVTLPEGMKE 131

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +   P+     K    HD  +++        VSKE+  +++  T        ++    
Sbjct: 132 NEKFPNPIITPTTKAYKGHDENISKEEIIERFLVSKEDYEQLEYYTRALFQRGTEIASSK 191

Query: 170 GLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQSL 218
           GLILVD K EFG   G + L DE  +PD SR +  E  +          ++ K+  RQ L
Sbjct: 192 GLILVDTKYEFGKKDGRIYLIDEIHTPDSSRYFYSEDYQERFEKGEGQKQLSKEFVRQWL 251


>UniRef50_C6BVA6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=23
           Tax=cellular organisms RepID=PUR7_DESAD
          Length = 299

 Score =  232 bits (592), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 68/257 (26%), Positives = 103/257 (40%), Gaps = 40/257 (15%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           +++   L RGK + +Y  ++ D L+L   +  SA D       D KG + N+   F M  
Sbjct: 10  IKELKLLSRGKVRDIYEVDD-DKLLLVTTDRISAYDVIMPNPIDDKGKILNQITLFWMDM 68

Query: 61  LAEAGIPTQMER---------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL 105
             +  IP  +                  L     LVKK   +P+EC+VR    GS  K  
Sbjct: 69  FKDI-IPNHLIASKVDDYPEVLHKYRDQLEGRSVLVKKAKPLPIECIVRGYITGSGWKDY 127

Query: 106 -------------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARM 151
                        G++E   L  PLF    K +   HD  ++         + KE   ++
Sbjct: 128 QKTGEVCGHKLPEGLKESEMLEQPLFTPSTKAELGEHDENISVEKATEM--LGKELFDKV 185

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLE--- 207
           +E T       +    + G+I+ D K EFG+Y GE+++ DE  +PD SR W  E  E   
Sbjct: 186 QEATLSIYKRGRDYAREKGIIIADTKFEFGIYDGELIIIDEVLTPDSSRFWPVEGYEAGK 245

Query: 208 ---KMDKDRFRQSLGGL 221
                DK   R  L  +
Sbjct: 246 SQPSFDKQFLRDWLTEI 262


>UniRef50_Q313T8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Desulfovibrionaceae RepID=Q313T8_DESDG
          Length = 298

 Score =  232 bits (591), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 63/255 (24%), Positives = 103/255 (40%), Gaps = 40/255 (15%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           + +   L RGK + +Y   + + L++   +  SA D    E    KG++ N    F M +
Sbjct: 9   IAEYKLLSRGKVRDIYEV-DAETLLIVTTDRMSAFDVIMGEPIPYKGVILNSITLFWMER 67

Query: 61  LAEAGIPTQMER---------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL 105
            A+  +P  +                 +L     LV+K   +PVEC+VR    GS  K  
Sbjct: 68  FADL-VPNHLIASDVKDFPQALHKYADMLEGRAVLVRKAAPLPVECIVRGHITGSGWKDY 126

Query: 106 -------------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARM 151
                        G+ E  +L  PLF    K +   HD  ++         V  +  A++
Sbjct: 127 QKTGMVCGHSLPAGLVESAKLETPLFTPSTKAELGEHDENISVQRARE--LVGDDVAAQI 184

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLE--- 207
           + L+ +     ++  +  G+I+ D K EFG+  G V+L DE  +PD SR W  +  +   
Sbjct: 185 ERLSIEIFSKGREYAESRGIIIADTKFEFGIIDGAVILIDEVLTPDSSRFWPVQGYQPGK 244

Query: 208 ---KMDKDRFRQSLG 219
                DK   R  L 
Sbjct: 245 SQPSFDKQYLRDWLS 259


>UniRef50_B8IQA8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Proteobacteria RepID=B8IQA8_METNO
          Length = 323

 Score =  232 bits (591), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 56/255 (21%), Positives = 88/255 (34%), Gaps = 34/255 (13%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           RGK +  Y   +    +L   +  SA D         KG V  +   +      +   P 
Sbjct: 27  RGKVRDNYDLPDGRR-ILISSDRISAFDRILAA-IPFKGQVLTQTARYWFEATRDLC-PN 83

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEEG 110
            +         + ++LD++PVE VVR   AG    S++ +               G+   
Sbjct: 84  HVLDYPDPNVVVARRLDILPVEIVVRGYLAGTTATSILTQYRAGLREMYGHRLPDGMRPN 143

Query: 111 IELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             L   +     K  +  HD  +        G +++E    +           ++L    
Sbjct: 144 ERLPEAILTPTTKAGEGGHDTPLTPDAILAQGLLTQEQWETVSRAALALFARGQELAARR 203

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQS 217
           GLIL D K EFG    G +VL DE  +PD SR W   +           E  DKD  R  
Sbjct: 204 GLILADTKYEFGTDADGRIVLADEIHTPDSSRYWFAASYPERFAAGTAPESFDKDFIRNW 263

Query: 218 LGGLIEAYEAVARRL 232
           +    + Y      +
Sbjct: 264 VVARCDPYRDAIPAI 278


>UniRef50_C1A3U9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Bacteria RepID=C1A3U9_GEMAT
          Length = 314

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 61/252 (24%), Positives = 104/252 (41%), Gaps = 42/252 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            + RGK + VY+ ++ D L++   +  SA D    E    KG V  +   + +++LA   
Sbjct: 15  LVRRGKVRDVYAVDD-DRLLMVTTDRISAFDVVMHEAIPYKGAVLTQVTAWWLAQLAGM- 72

Query: 66  IPTQME------------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
           +   +                     L+    L  + D+VP+ECV+R    GS  K    
Sbjct: 73  VDHHLITAETDEIIAAVPSLAPYRDALAGRSMLTVRADVVPIECVIRGYITGSAWKEYRE 132

Query: 106 -----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKEL 154
                      G++E   L+PP+F    K +  HD  +  S   +   V  +  A+++ L
Sbjct: 133 HGTLAGEALKAGLQESDRLDPPIFSPATKAETGHDENITVSKVISE--VGADTAAQLESL 190

Query: 155 TYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLE------ 207
             +  +  +   +  G+I+ D K EFG   G+++L DE  +PD SR W  ++        
Sbjct: 191 ARRIYEYGRATAEPRGIIVADTKFEFGWRDGKLLLIDEVLTPDSSRFWPADSYAPGRGQP 250

Query: 208 KMDKDRFRQSLG 219
             DK   R  L 
Sbjct: 251 SFDKQPLRDWLD 262


>UniRef50_A7H9G3 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=5
           Tax=Myxococcaceae RepID=A7H9G3_ANADF
          Length = 320

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 62/238 (26%), Positives = 99/238 (41%), Gaps = 30/238 (12%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           LYRGK +  YS    D +V+   +  SA D         KG V ++   F   K+ +   
Sbjct: 26  LYRGKVRDNYS--RGDRIVMVTTDRVSAFDHVL-GTIPFKGEVLSRLTAFWFEKVKDVA- 81

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEGIE 112
           PT +  L   +  +VK+   +P+E V+R    GSL +                G+ +   
Sbjct: 82  PTHVVDLPDPSVMVVKRAKPLPIEIVIRGYITGSLWRDYQAGKAGAYGIEWPKGLRKDQR 141

Query: 113 LNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGL 171
            + P+     K +   HD  ++E    + G V+ E       +  +     ++     GL
Sbjct: 142 FDRPIITPSTKAEYGKHDEPISEQELLSQGLVAPELWREATAVAERLFARGQEWALSRGL 201

Query: 172 ILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQSL 218
           ILVD K E G+  G++V+ DE  +PD SR W  +  E           +DK+  RQ L
Sbjct: 202 ILVDTKYEMGVVDGKLVVIDEIHTPDSSRYWVADGYEDRFARGAEQEMLDKENIRQWL 259


>UniRef50_B5GT63 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Streptomyces clavuligerus ATCC 27064
           RepID=B5GT63_STRCL
          Length = 345

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 63/257 (24%), Positives = 97/257 (37%), Gaps = 35/257 (13%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L+ GK + +Y  E  D L++   +  SA D     +   KG V  + + +   +LA+  
Sbjct: 18  HLHTGKVRDLYRNEAGD-LIMVASDRISAYDWVLPSEIPDKGRVLTRLSLWWFDRLADL- 75

Query: 66  IPTQMERLL---------SDTECLVKKLDMVPVECVVRNRAAGSLVKRL----------- 105
           +P  +                  + + L MVPVECV R    GS +              
Sbjct: 76  VPHHVVSTDLPDGAPADWEGRTLVCRSLRMVPVECVARGYLTGSGLVEYDESRTVCGITL 135

Query: 106 --GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
             G+ +G EL  P+F    K     HD  V          V  E  A +++ T       
Sbjct: 136 PEGLSDGSELPAPIFTPATKAAVGDHDENVTYEEVARQ--VGAETAAVLRQTTLAVYGRA 193

Query: 163 KKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE------KMDKDRF 214
           + +  D G+IL D K EFG    G +V+ DE  +PD SR W   + +        DK   
Sbjct: 194 RDIARDRGIILADTKFEFGHTEDGTLVIADEVLTPDSSRFWPAASWQPGRPQPSYDKQYV 253

Query: 215 RQSLGGLIEAYEAVARR 231
           R  L      ++    +
Sbjct: 254 RDWLTSPASGWDRRGEQ 270


>UniRef50_Q8UCE7 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2
           n=32 Tax=Alphaproteobacteria RepID=PUR72_AGRT5
          Length = 316

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 58/256 (22%), Positives = 100/256 (39%), Gaps = 34/256 (13%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           YRGK +  Y   + + +++   +  SA D         KG V  +   +   +  +   P
Sbjct: 16  YRGKVRENYDLPDGNRIII-STDRLSAFDQIL-TCIPYKGQVLTQTARYWFEQTKDIC-P 72

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEE 109
             +         + K+LD++PVE VVR   AG    S++                 G+++
Sbjct: 73  NHVVSYPDPNVVIGKRLDILPVEVVVRGYLAGTTGTSILTLYKKGERQMYGMSLPDGMKD 132

Query: 110 GIELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDD 168
              L  P+     K  D  HD  +  S       +++E    +           +++   
Sbjct: 133 NQILPEPVITPTSKAFDGGHDEPLTPSEIVEKKLLTQEQWDTLSRYALALFRHGQEIAAK 192

Query: 169 AGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQ 216
            GLILVD K EFG  + G ++L DE  +PD SR W  ++ +            DKD  R 
Sbjct: 193 QGLILVDTKYEFGTDENGTIILADEIHTPDSSRYWMADSYDESFREGKRPASFDKDFVRA 252

Query: 217 SLGGLIEAYEAVARRL 232
            +G   + Y+    ++
Sbjct: 253 WVGERCDPYKDAVPKI 268


>UniRef50_C9KPE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Mitsuokella multacida DSM 20544 RepID=C9KPE2_9FIRM
          Length = 290

 Score =  231 bits (589), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 65/258 (25%), Positives = 97/258 (37%), Gaps = 43/258 (16%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M++      GK + VY  +  D +++   +  SA D     Q  +KG V  + + F    
Sbjct: 1   MKEYKPFKSGKVREVY--DAGDSIIMVATDRISAFDHILKNQITKKGKVLTQMSKFWFDF 58

Query: 61  LAEAGIPTQMERLLS-------------DTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
             +  IP  M  + +                   KKL M+P+EC+VR    GS       
Sbjct: 59  TKDI-IPNHMISVDNNDMPEFFRQPQFLGNSMKCKKLTMLPMECIVRGYITGSGWASYQE 117

Query: 106 -----------GIEEGIELNPPLFDLFLKND-AMHDPMVNESY-----CETFGWVSKENL 148
                      G++E  +L  P+F    K +   HD  V+         + F     E  
Sbjct: 118 NGTVCGIKLPEGLKESQKLPEPIFTPSTKAELGDHDENVSLEQGAAVFEKEFPGHGMEYA 177

Query: 149 ARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL 206
            ++++ T              G+I+ D K EFGL   G +VLGDE  +PD SR W  E  
Sbjct: 178 EKLRDYTIAIYKKCAAYALSRGIIIADTKFEFGLDEDGNIVLGDEVLTPDSSRFWPLEGY 237

Query: 207 E------KMDKDRFRQSL 218
           E        DK   R  L
Sbjct: 238 EAGKPQPSYDKQFVRDWL 255


>UniRef50_B2KCE9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Elusimicrobium minutum Pei191 RepID=PUR7_ELUMP
          Length = 292

 Score =  230 bits (586), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 63/252 (25%), Positives = 99/252 (39%), Gaps = 42/252 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            L +GK + VY  +   +L++   +  S  D     Q   KG +  + + F  +K     
Sbjct: 10  LLKKGKVRDVY--DAGKMLLIVASDRVSVFDCVLPSQIPDKGKILTQISNFWFAKTISI- 66

Query: 66  IPTQMER-----------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--- 105
           +P  M                     S    LVKK + +  ECVVR    GS  K     
Sbjct: 67  VPNHMISSDINEINIILKLGLDPQYYSGRTVLVKKCERIDFECVVRGYITGSAWKEYQKS 126

Query: 106 ----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELT 155
                     G++E  +   P+F    K D  HD  V+ +Y      + K    ++K+ +
Sbjct: 127 GTVCGEKIKEGLKEAQKFPEPIFTPASKADTGHDENVSFAYM--LSHMDKNLAYKIKDTS 184

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK------ 208
            K  +  ++   + G+IL D K EFGL  G+++L DE  +PD SR WD    +       
Sbjct: 185 IKLYNFAEEYLKNCGIILADTKFEFGLIDGDLILIDEILTPDSSRFWDAALYKTGTNPPG 244

Query: 209 MDKDRFRQSLGG 220
            DK   R  +  
Sbjct: 245 FDKQFVRDYMEQ 256


>UniRef50_A6GYJ4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=22
           Tax=Bacteroidetes RepID=PUR7_FLAPJ
          Length = 316

 Score =  230 bits (586), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 58/243 (23%), Positives = 98/243 (40%), Gaps = 29/243 (11%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
            Q  +YRGK + VY+  + +LLV+   +  SA D    E    KG + N+     M    
Sbjct: 13  NQKSVYRGKVREVYNIND-ELLVMVATDRLSAFDVVLPEGIPYKGQILNQIATKFMELTQ 71

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIE 108
           +  +P  +         +    +   VE V+R   +G   +                G++
Sbjct: 72  DI-VPNWLIATPDPNVAVGHLCEPFKVEMVIRGYLSGHAAREYALGKRTICGVTMPEGLK 130

Query: 109 EGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
           E  +   P+     K D   HD  ++ S       VS+++   +++ T        ++  
Sbjct: 131 ENDQFPTPIITPTTKADNGSHDEDISRSAILAKNIVSEQDYLVLEKYTRDLYQRGTEIAA 190

Query: 168 DAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFR 215
             GLILVD K EFG    G++VL DE  +PD SR +  E  +          ++ K+  R
Sbjct: 191 SRGLILVDTKYEFGKTKDGKIVLIDEIHTPDSSRYFYAEGYQDRQNNEEEQKQLSKEFVR 250

Query: 216 QSL 218
           + L
Sbjct: 251 RWL 253


>UniRef50_B5JQ22 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JQ22_9BACT
          Length = 308

 Score =  229 bits (585), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 57/257 (22%), Positives = 100/257 (38%), Gaps = 40/257 (15%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           +  ++  GK + +Y  ++   ++L   +  SA D         +G++  + ++F   +  
Sbjct: 24  EAQKIASGKVREIYDLDDS--VLLVATDRISAFDVVLPGGIPGRGLILTQLSHFWFEQTK 81

Query: 63  EAGIPTQMERLLSD--------------TECLVKKLDMVPVECVVRNRAAGSLVKRL--- 105
               P  +     +                  V+KL  + +ECVVR   AGS  +     
Sbjct: 82  HIA-PNHILPNEQEILAGRLQLSRDSQLRSMAVRKLQPLEIECVVRGYIAGSGWESYQKD 140

Query: 106 ----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELT 155
                     G++   +L  P+F    K    HD  V+ S       V ++   ++K ++
Sbjct: 141 RTVCGIELPAGLQLASQLPEPIFTPTTKASEGHDMPVSPSEAAA--IVGQDVFDQVKAIS 198

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE------ 207
            +  +   +L   AG+IL D K EFG  + G++ L DE  +PD SR WD           
Sbjct: 199 LELYNFGSQLAAKAGIILADTKFEFGTDESGKIYLIDEVLTPDSSRYWDAAEYRVGSSPA 258

Query: 208 KMDKDRFRQSLGGLIEA 224
             DK   R  L  L + 
Sbjct: 259 SYDKQIIRDYLETLKDW 275


>UniRef50_A8LCN0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacteria RepID=A8LCN0_FRASN
          Length = 354

 Score =  229 bits (584), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 61/260 (23%), Positives = 99/260 (38%), Gaps = 43/260 (16%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L  GK + +++  + D ++L   +  SA D     +   KG V    + +   +L + 
Sbjct: 63  THLGSGKVRELFAIGD-DAVLLVASDRISAFDVVLPTEIPDKGAVLTGLSLWWFDQLGDL 121

Query: 65  GIPTQME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
            +P+ +                  L     L ++LDMV +ECV R    GS +K      
Sbjct: 122 -VPSHVISSSVDEYPAELAPYAEQLRGRSMLCRRLDMVQIECVARGYLTGSGLKDYRRSG 180

Query: 106 ---------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELT 155
                    G+E+G  L  P++    K     HD  ++       G V  E  A ++ LT
Sbjct: 181 TVSGHPLPAGLEDGSRLPNPIYTPSTKAPIGEHDENISRDD--AAGRVGAELAAELERLT 238

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE------ 207
            +       L  + G++L D K EFG    G + L DE  +PD SR W  +         
Sbjct: 239 LQIFGRASDLAAERGILLADTKFEFGHDADGVLRLADEVLTPDSSRFWPADAWTPGGTQP 298

Query: 208 KMDKDRFRQSLGGLIEAYEA 227
             DK   R  L  +   ++ 
Sbjct: 299 SYDKQFIRDYL--VSTGWDR 316


>UniRef50_Q648Z8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=uncultured archaeon GZfos35D7 RepID=Q648Z8_9ARCH
          Length = 249

 Score =  227 bits (579), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 73/242 (30%), Positives = 120/242 (49%), Gaps = 22/242 (9%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           GK+K ++  E       EF + T+A DG + ++F  KG V  + + +    L EAGIPT 
Sbjct: 9   GKSKDIF--EEDGKTFFEFTDRTTAFDGVKEDEFSHKGEVCCRLSTYWFEILEEAGIPTH 66

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEE----------GIELNPPLFD 119
               +      V+ LD++P+E + RN  AGS+++R    E          G  +   + +
Sbjct: 67  FRAFVPPNIMEVEPLDILPIEVIWRNFVAGSILRRHERGESLPIEIEPRLGARIPGGMVE 126

Query: 120 LFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLE 179
              K +A  D  ++E      GW++   L  ++E T   N+++ +     G+IL DFK+E
Sbjct: 127 FTTKFEAK-DRPIDEQEILDNGWLTSAELDSIRECTRLTNEIMSERLLKRGIILADFKIE 185

Query: 180 FGLYKG---EVVLGDEF-SPDGSRLWDKETL-----EKMDKDRFRQSLGGLIEAYEAVAR 230
           FG  K    +++L DE  +PDG R WD++       E +DKD +R   G L + Y  + R
Sbjct: 186 FGRDKNAAEKILLADEVGTPDGCRFWDRDAYEQGVIESLDKDVYRYDKGDLSDVYLRIQR 245

Query: 231 RL 232
           R+
Sbjct: 246 RI 247


>UniRef50_Q9UUB4 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=59
           Tax=cellular organisms RepID=PUR7_SCHPO
          Length = 299

 Score =  225 bits (575), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 62/251 (24%), Positives = 93/251 (37%), Gaps = 40/251 (15%)

Query: 5   AELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
            ++  GK + +Y   E PD L+    +  SA D         KG V  K + F    L  
Sbjct: 13  TKIATGKVRDLYECVEFPDDLLFVATDRISAYDFIMENGIPEKGKVLTKISEFWFDVLKP 72

Query: 64  AGIPTQME--------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
             + T +                 L D   LVKK  ++P+E +VR    GS  K      
Sbjct: 73  H-VQTHLITSRWEELPPVITKHEELKDRSMLVKKYKILPIEAIVRGYITGSAWKEYQKQG 131

Query: 106 ---------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTY 156
                    G++E      PLF    K    HD  ++         V  E   ++ E + 
Sbjct: 132 TVHGLNVPTGMKEAEAFPEPLFTPSTKAAEGHDENIHPDEV--SKIVGPELAKQVAETSV 189

Query: 157 KANDVLKKLFDDAGLILVDFKLEFGLYK--GEVVLGDEF-SPDGSRLWDKETL------E 207
           K   + + +    G+I+ D K EFG+ +   ++VL DE  +PD SR W           +
Sbjct: 190 KLYKIARDVALKKGIIIADTKFEFGVDETTNKIVLVDEVLTPDSSRFWLASDYTVGKSPD 249

Query: 208 KMDKDRFRQSL 218
             DK   R  L
Sbjct: 250 SFDKQYLRNWL 260


>UniRef50_A8AAS3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ignicoccus hospitalis KIN4/I RepID=A8AAS3_IGNH4
          Length = 235

 Score =  225 bits (575), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 85/232 (36%), Positives = 133/232 (57%), Gaps = 9/232 (3%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             +Y GK K VY  +  D ++L+F++  +A DG ++E+   KG VN +F   +M  L + 
Sbjct: 2   KLIYEGKTKKVYDMD--DKVLLKFKDVFTAFDGKKVEEVKGKGKVNAEFTELLMKYLEQH 59

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG-IEEGIELNPPLFDLFLK 123
           G+ T      ++ E +  K   +P+E +VRN A GSL+KRL  +E+G  L  P+F++  K
Sbjct: 60  GVKTHFLSR-NEDEIVAIKTKPLPLEFIVRNYAYGSLLKRLPILEKGQRLLTPVFEVHYK 118

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           +D +HDP++ E      G VSK+ +  ++E T K N++L +LF+ AG  L+DFK+E+G+ 
Sbjct: 119 SDELHDPLLAEDDPVAAGIVSKDVMKTIRETTLKVNELLTELFEKAGFKLIDFKVEYGIT 178

Query: 184 -KGEVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSL--GGLIEAYEAVARRL 232
             G VVL DE SPD  R    +  E  DKD FRQ      +++ Y  +   L
Sbjct: 179 EDGRVVLIDELSPDSFRA--HKGGEAYDKDLFRQGASGEEVLKKYVELLEAL 228


>UniRef50_A4SAQ9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ostreococcus lucimarinus CCE9901 RepID=A4SAQ9_OSTLU
          Length = 367

 Score =  225 bits (574), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 54/250 (21%), Positives = 94/250 (37%), Gaps = 35/250 (14%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK +  Y T   D ++    +  SA D         KG V N+ + +   +     +P
Sbjct: 72  YEGKVRDTYVT--GDTMIAVTTDRQSAFDRHL-AYIPFKGAVLNQTSQWWFKQTEHI-VP 127

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGS----LVKRL--------------GIEE 109
             +         ++++ ++ P+E VVR    GS    L                  G+ +
Sbjct: 128 NAVVATPDPNVTVMRRCEVFPIEFVVRGYLTGSTSTSLWTHYKTGGRNYCGNALDDGMVK 187

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             +L   +     K +  HD  ++       GW+ +++L      T +     +++    
Sbjct: 188 NQKLPANIVTPTTK-EKEHDRPISLEDIVKEGWMKQDDLDYCVAKTLEVFAYAQEVAATR 246

Query: 170 GLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQS 217
           GLILVD K EFG    G + L DE  +PD SR W   +           + +DK+  R  
Sbjct: 247 GLILVDTKYEFGRDADGTIRLIDEINTPDSSRYWLSNSYVERHAAGMEPDMIDKEFLRLW 306

Query: 218 LGGLIEAYEA 227
                + Y+ 
Sbjct: 307 FAERCDPYKD 316


>UniRef50_Q72UH8 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=6
           Tax=Leptospira RepID=PUR7_LEPIC
          Length = 285

 Score =  224 bits (572), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 69/247 (27%), Positives = 100/247 (40%), Gaps = 40/247 (16%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y+GK + +Y     D L+L   +  SA D    +    KG V N+ +        +  +P
Sbjct: 5   YKGKVRDIYDL--GDKLILSSSDRISAFDVVFPQLVPDKGKVLNRISVSWFEFFKD--VP 60

Query: 68  TQMERL--------------LSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-------- 105
             +                 L     LVKK   +  ECVVR   +GS  K          
Sbjct: 61  NHILETDVKYFPIPFQNHPDLEGRSVLVKKCKRIDYECVVRGYISGSGWKEYKNDGTLAG 120

Query: 106 -----GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
                G +E  +L  P+F   +KND  HD  ++E   E    + KE    +KE +     
Sbjct: 121 IKLPSGFKESQKLPEPVFTPAVKNDQGHDENISEKEME--NRIGKELFNILKEKSISIFL 178

Query: 161 VLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE------KMDKDR 213
              ++ D AG+IL D K EFG+  G+V+L DE  +PD SR W  +T         +DK  
Sbjct: 179 RASEVVDKAGIILCDTKFEFGILDGQVILIDELLTPDSSRYWSTDTYSVGISPPSLDKQI 238

Query: 214 FRQSLGG 220
            R  L  
Sbjct: 239 LRNYLET 245


>UniRef50_Q7UJ19 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Rhodopirellula baltica RepID=PUR7_RHOBA
          Length = 320

 Score =  224 bits (572), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 56/264 (21%), Positives = 95/264 (35%), Gaps = 56/264 (21%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKL------- 61
           +GK + VY     D L++   +  SA D         KG +    + F   ++       
Sbjct: 24  QGKVRDVYDL--GDRLLIVSSDRISAFDYILPTGIPDKGRLLTAMSRFWFEQMDAGRIGQ 81

Query: 62  -----------AEAGIPTQMER--------------LLSDTECLVKKLDMVPVECVVRNR 96
                          I   +                 L     + +K  +VP ECVVR  
Sbjct: 82  NVGSAGGDGSSNPRSISHHLISTDVPEDVAAVVDPKPLEGRVMVTRKASVVPFECVVRGY 141

Query: 97  AAGSLVKRL-------------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWV 143
             GS  K               G+++  +L+  +F    K +  HD  V+         +
Sbjct: 142 LEGSGWKEYQATGEVCGVSLPAGLKQCDQLSEAIFTPATKAEEGHDENVSYE--VMSQSL 199

Query: 144 SKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWD 202
            +E  ++++ ++        K+  + GL++ D K EFG+  GE++L DE  +PD SR W 
Sbjct: 200 GEEQSSQLRRMSLAIYQDASKIAAERGLLIADTKFEFGVVDGELMLIDEVLTPDSSRFWA 259

Query: 203 KETLE------KMDKDRFRQSLGG 220
            +  E        DK   R+ L  
Sbjct: 260 ADEYEPGHSQRSFDKQFVREYLQE 283


>UniRef50_C0A6D3 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Opitutaceae bacterium TAV2 RepID=C0A6D3_9BACT
          Length = 306

 Score =  221 bits (563), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 57/251 (22%), Positives = 91/251 (36%), Gaps = 42/251 (16%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
           ++  GK +  +     D L++   +  SA D    +    KG++  + + +  ++   AG
Sbjct: 25  KIATGKVRENFDL--GDALLIAATDRLSAFDVILPDGIPGKGIILTQISNWWFAQAERAG 82

Query: 66  I--PTQME--------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---- 105
           I  P  +               R +     +V+KL  + +EC+VR    GS         
Sbjct: 83  ISLPNHLLPDQAGEFARRGITDRDIQLRSMIVRKLKPLAIECIVRGYLVGSGWSSYQKTG 142

Query: 106 ---------GIEEGIELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELT 155
                    G+ +   L  PLF    K     HD  +N++       V      ++K  +
Sbjct: 143 EVCGHRLPAGLRQADRLPAPLFTPTTKAPKGEHDAPINDAQGAA--IVGPALYEQVKAAS 200

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE------ 207
                +       AG+IL D K EFG    G +VL DE  +PD SR W            
Sbjct: 201 LALYSLGHDKAARAGMILADTKFEFGTDAAGNLVLIDEILTPDSSRYWPAGQYAPDQSPP 260

Query: 208 KMDKDRFRQSL 218
             DK   R  L
Sbjct: 261 SYDKQYVRDHL 271


>UniRef50_Q11TT6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=13
           Tax=Bacteria RepID=PUR7_CYTH3
          Length = 310

 Score =  220 bits (560), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 57/237 (24%), Positives = 98/237 (41%), Gaps = 28/237 (11%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
            Y+GK + VY     D LV+   +  SA D         KG V N+    ++++ A+  +
Sbjct: 17  FYKGKVRDVYYV--ADKLVVVASDRISAFDVVLPRAIPFKGQVLNQIAAKMLAQTADV-V 73

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--------------IEEGIE 112
           P  +  +   +  +  K +   VE V+R   AG   +                 ++E  +
Sbjct: 74  PNWILSVPDPSVSIGIKCEPFKVEMVIRGYLAGHAAREYKAGKRTLCGVALPEELKENDK 133

Query: 113 LNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLI 172
           L  P+     K D  HD  ++       G VS+ +  ++++ T        +L +  GLI
Sbjct: 134 LPAPIITPTTKADEGHDEDISREDLLARGIVSEADYIQLEKYTQALFQRGTELAEKQGLI 193

Query: 173 LVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETL----------EKMDKDRFRQSL 218
           LVD K EFG    ++ L DE  +PD SR +  +            +++ K+  RQ L
Sbjct: 194 LVDTKYEFGKVGDKIYLIDEIHTPDSSRYFYIDGYAERQAKGEAQKQLSKEFVRQWL 250


>UniRef50_P38025 Phosphoribosylaminoimidazole-succinocarboxamide synthase,
           chloroplastic n=17 Tax=cellular organisms
           RepID=PUR7_ARATH
          Length = 411

 Score =  220 bits (560), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 57/249 (22%), Positives = 92/249 (36%), Gaps = 35/249 (14%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y  +  D LVL   +  SA D         KG V N+ + +  +       P 
Sbjct: 111 KGKVRDIY--DAGDYLVLITTDRLSAFDRNLAS-IPFKGQVLNETSLWWFNNTQHI-TPN 166

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGS-----------LVKRL-------GIEEG 110
            +         + KK  + P+E VVR    GS            V+         G+ + 
Sbjct: 167 AIVSSPDRNVVIAKKCSVFPIEFVVRGYVTGSTDTSLWTVYNKGVRNYCGNELSDGLVKN 226

Query: 111 IELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
            +L   +     K  A HD  ++ +     G++++              +  + +    G
Sbjct: 227 QKLPANILTPTTKA-ADHDVPISPNEIVEGGFMTQAEFDEASMKALSLFEFGQGVAKKHG 285

Query: 171 LILVDFKLEFGL-YKGEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQSL 218
           LILVD K EFG    G ++L DE  +PD SR W   + E+          +DK+  R   
Sbjct: 286 LILVDTKYEFGRSSDGSILLIDEIHTPDSSRYWLAGSYEERFQKGLEPENVDKEFLRLWF 345

Query: 219 GGLIEAYEA 227
                 YE 
Sbjct: 346 KENCNPYED 354


>UniRef50_B0VH32 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Candidatus Cloacamonas acidaminovorans
           RepID=B0VH32_9BACT
          Length = 293

 Score =  219 bits (559), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 60/247 (24%), Positives = 93/247 (37%), Gaps = 40/247 (16%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           +GK + +Y     + L++   +  SA D         KG + N  + +  +   +  +P 
Sbjct: 16  QGKVRDIYDL--GETLLIVSTDRISAFDVVFPTLIPDKGKILNAISVYFFNATKDI-VPN 72

Query: 69  QME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG------- 106
                               L +   LVKK  ++P E +VR   +GS  K          
Sbjct: 73  HFITANISEYPVELQPFGEYLEERSMLVKKTRVIPFEFIVRGYLSGSAWKEYKKSNTIGG 132

Query: 107 ------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKAND 160
                 ++E  +   PLF    K +  HD  ++  Y E    + +     +K+ + +   
Sbjct: 133 MLIAEEMQESQKFPHPLFTPSTKAENGHDENIS--YREFMSRMDESLAVYIKDKSLELYS 190

Query: 161 VLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLE------KMDKDR 213
               L    G+IL D K EFG    EV+L DE F+PD SRLW  E  E        DK  
Sbjct: 191 YAHDLLLKKGIILADTKFEFGTIGSEVLLIDELFTPDSSRLWSLEDYEMGKSPKSYDKQF 250

Query: 214 FRQSLGG 220
            R  L  
Sbjct: 251 IRDYLEN 257


>UniRef50_A7BA15 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Actinomyces odontolyticus ATCC 17982
           RepID=A7BA15_9ACTO
          Length = 333

 Score =  218 bits (556), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 56/293 (19%), Positives = 97/293 (33%), Gaps = 73/293 (24%)

Query: 5   AELYRGKAKTVYSTEN----------------------PDLLVLEFRNDTSAGDGARIEQ 42
             L  GK + +Y+ +                       P+ L++   +  SA D      
Sbjct: 9   TPLSAGKVRDIYAPDEAVVGPAPQTATQAGCPRHAKAGPEALLMVTSDRISAYDYVLPTL 68

Query: 43  FDRKGMVNNKFNYFIMSKLAEAGIPTQMERL-------------------------LSDT 77
              KG V N+   + M +L    +   +  +                         +   
Sbjct: 69  IPGKGAVLNQLAIWWMGQLRPL-VENHLLAVGTKAPAEASRALEGAQPTRFTVPAEVDGR 127

Query: 78  ECLVKKLDMVPVECVVRNRAAGSLVKRL-------------GIEEGIELNPPLFDLFLKN 124
             + + L M+P+ECVVR    GS +                G+ E   L  P+F    K 
Sbjct: 128 AVVCRSLHMIPIECVVRGYLTGSGLAEYRESGSVCGIKLPEGLTEASRLEEPIFTPAAKA 187

Query: 125 D-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           +   HD  +          + +E    +++L+       + +  + G+I+ D K EFG+ 
Sbjct: 188 ELGEHDENITFEQTVER--IGEELAVAIRDLSIALYRAARDIAAERGIIIADTKFEFGID 245

Query: 184 --KGEVVLGDEF-SPDGSRLWDKETLE------KMDKDRFRQSLGGLIEAYEA 227
              G +VL DE  +PD SR W  +           DK   R  L      ++ 
Sbjct: 246 VTTGALVLADEILTPDSSRFWPADQWVEGQVAPSFDKQYLRDWLVSEQSGWDR 298


>UniRef50_A9A5G9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Thaumarchaeota RepID=PUR7_NITMS
          Length = 274

 Score =  218 bits (556), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 75/231 (32%), Positives = 112/231 (48%), Gaps = 23/231 (9%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L  GK K +Y  +    L+ +F +  SA D    +   RKG V  KF  F  ++L   
Sbjct: 2   EFLTSGKVKDLYDVDES-TLLFKFSDRVSAYDVKFKQDIPRKGEVLCKFAEFWFNEL--- 57

Query: 65  GIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-----LGIEEGI------EL 113
            +P    +  S+ E LVKK+ M+P+ECVVR    GSLV R     + + EG       +L
Sbjct: 58  DVPNHFIKRESENEILVKKMKMLPIECVVRGYFYGSLVSRWKKGEVQVPEGTNTTLAAQL 117

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
             P+FD   K++  HD  ++++       VS+E    +++ + +    + K+ DD G IL
Sbjct: 118 PEPIFDPTTKSE--HDIPIDKNKAIEMNLVSEEQYNWLEKTSIEIYKKMAKITDDVGFIL 175

Query: 174 VDFKLEFGLYKGEVVLGDEFSPDGSRLWDKETL------EKMDKDRFRQSL 218
            D KLEFG+   ++ LGD   PD  RLW K++       E  DK   R  L
Sbjct: 176 ADLKLEFGILDDQITLGDSIGPDEYRLWPKDSFEVGKIQEAYDKQLLRDWL 226


>UniRef50_C6CV28 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=4
           Tax=Bacillales RepID=C6CV28_PAESJ
          Length = 299

 Score =  216 bits (552), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 64/250 (25%), Positives = 100/250 (40%), Gaps = 39/250 (15%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K   LY+GK + +Y      L+V+   +  SA D        +KG V N+ + F   + A
Sbjct: 16  KAPLLYKGKVRELYDLGEHYLIVV--TDRISAFDYVLDPAVPQKGNVLNRLSAFWFEQTA 73

Query: 63  EAGIPTQME--------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--- 105
           +      +                LL D   + KK + + +ECVVR    G   ++    
Sbjct: 74  DIQ-TNHVVHTDVEKLGDIVTAPELLKDRIMVTKKAERIDIECVVRGYITGGGWRQYQQT 132

Query: 106 ----------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELT 155
                     G+ +      P+F    KND  HD  +     +    V  E    +K  +
Sbjct: 133 SAINGIQLPEGMRKNERFPQPIFTPAAKNDVGHDEDIPFERMQEM--VGAELAEELKGRS 190

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETL------EK 208
            K  +   +     G+IL D K EFGL  G+V+L DE  +PD SR W +++       + 
Sbjct: 191 IKLYEFAHEYCAKHGIILADCKFEFGLIDGKVILIDEIFTPDSSRFWGEKSYAYDIEIDS 250

Query: 209 MDKDRFRQSL 218
           MDK+  R  L
Sbjct: 251 MDKEPVRTYL 260


>UniRef50_B7FS23 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Bacillariophyta RepID=B7FS23_PHATR
          Length = 562

 Score =  216 bits (552), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 59/248 (23%), Positives = 94/248 (37%), Gaps = 36/248 (14%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           RGK +  Y       L L   +  S  D     +   KG V N  + F   + A   IP 
Sbjct: 268 RGKVRDRYPGTKS--LALVTTDRQSGFDRML-ARVPYKGAVLNLTSAFWFEQTAHI-IPN 323

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGS----LVKRL--------------GIEEG 110
            +  +      +VK     P+E VVR+   GS    + +                G+ + 
Sbjct: 324 HLVSVPHPYVSVVKPCQPFPIEFVVRSYMTGSTSTSIWRNYQEGVRSYCGHDLPDGMTKN 383

Query: 111 IELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
            +L   +     K +  HD  ++        W+++ +L        K   + +++    G
Sbjct: 384 QKLECNILTPTTK-EEDHDRPISLVDIVAENWMTQSDLDVCAAAALKVFALGQQVAAAHG 442

Query: 171 LILVDFKLEFGLYK--GEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQS 217
           LILVD K EFG  +  GE++L DE  +PD SR W   T E+          +DK+  R  
Sbjct: 443 LILVDTKYEFGKDEHTGEILLIDEVHTPDSSRYWLASTYEERIAAGEEPDNIDKEFLRLW 502

Query: 218 LGGLIEAY 225
                + Y
Sbjct: 503 FRSQCDPY 510


>UniRef50_Q3Z881 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Dehalococcoides ethenogenes 195 RepID=Q3Z881_DEHE1
          Length = 304

 Score =  216 bits (550), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 69/257 (26%), Positives = 99/257 (38%), Gaps = 47/257 (18%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
             +GK +  Y     D L++   +  SA D         KG V N+ + F   K A   I
Sbjct: 17  FIKGKVRDTYLL--GDKLLIIASDRISAFDVILPGGIPGKGRVLNRISSFWFEKTARI-I 73

Query: 67  PTQMERLLSDTECLVKKLDM----------------------VPVECVVRNRAAGSLVKR 104
           P  +  L+ D  CL K L                        V VECVVR   AGS    
Sbjct: 74  PNHVIELVEDVSCLDKYLPPEERFRYPEYLSGRSMVVKRVKRVSVECVVRGYIAGSAWSE 133

Query: 105 L-------------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARM 151
                         G+ +  EL  P+F    K +  HD  +  +  E    V KE   ++
Sbjct: 134 YKKTGTVNGMPMPKGLLQSQELPEPIFTPTTKGEGEHDHPMTIAELEAM--VGKELADKL 191

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL---- 206
            E +     + ++     G+I+ D K EFGL   E++L DE  +PD SR WD++T     
Sbjct: 192 AEKSLALYKLGREYARQRGIIIADTKFEFGLDGSELILIDEALTPDSSRFWDEKTYRVGE 251

Query: 207 --EKMDKDRFRQSLGGL 221
             +  DK   R  L  +
Sbjct: 252 AQDSYDKQPVRDYLEAI 268


>UniRef50_Q67KF6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Symbiobacterium thermophilum RepID=Q67KF6_SYMTH
          Length = 299

 Score =  215 bits (549), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 66/248 (26%), Positives = 97/248 (39%), Gaps = 36/248 (14%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIM------ 58
             L+RGK + ++   + D L++   +  SA D    +    KG V  + +          
Sbjct: 7   RRLHRGKVREMFEL-DADRLLMVATDRLSAFDVVFPQGIPGKGRVLTQLSALWFGATRHI 65

Query: 59  -------SKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------ 105
                    L   G+P  + RLL     +V++   + VECVVR   AGS  K        
Sbjct: 66  VANHLVSDDLGGLGLPGDVRRLLEGRSLVVRRARRIDVECVVRGYLAGSGWKEYQASGTV 125

Query: 106 -------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                  G+     L  P+F   LKND  HD  V E+       +       +KE +   
Sbjct: 126 CGIPLPAGLRLSSRLPEPIFTPALKNDRGHDENVPEAEVRRR--LGDAVTDFIKEKSLAL 183

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL------EKMDK 211
                 + + AG+IL D K EFG    E+VL DE F+PD SR W  +        + +DK
Sbjct: 184 YRYAAGVAEKAGMILADTKFEFGFVGDEIVLIDEAFTPDSSRYWPADRYREGEPVDSLDK 243

Query: 212 DRFRQSLG 219
              R    
Sbjct: 244 QPVRDWAE 251


>UniRef50_Q5P7J7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=216
           Tax=cellular organisms RepID=PUR7_AZOSE
          Length = 311

 Score =  215 bits (549), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 59/269 (21%), Positives = 95/269 (35%), Gaps = 49/269 (18%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           ++    L RGK + +Y+  + D L++   +  SA D    +    KG V      F  ++
Sbjct: 10  IKSLPLLGRGKVRDIYAV-DADKLLIVTSDRLSAFDVILPDPIPDKGRVLTAMAAFWFAR 68

Query: 61  LAEAGIPTQM-------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL-- 105
           L    +P Q+                +     +VK+L  +P+E VVR    GS  K    
Sbjct: 69  LGHI-VPNQLTGIDPESVVASDERDQVRGRSLVVKRLKPLPIEAVVRGYVIGSGWKDYQD 127

Query: 106 -----------GIEEGIELNPPLFDLFLKNDAM-HDPMVNES------YCETFGWV---- 143
                      G+ +  +L  P+F    K D   HD  ++ +        E  G +    
Sbjct: 128 TGAICGIRLPAGLAQAAKLPSPIFTPASKADVGDHDENISFAAAQTRCAAELTGLLAGSG 187

Query: 144 --SKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSR 199
                     ++                G+I+ D K EFG+   G + L DE  +PD SR
Sbjct: 188 TNGARLATEARDAAITLYVEAANYAAGRGIIIADTKFEFGIDSAGTLHLIDEALTPDSSR 247

Query: 200 LWDKETLE------KMDKDRFRQSLGGLI 222
            W  ++          DK   R  L  L 
Sbjct: 248 FWPADSYREGISPPSYDKQYVRDYLETLT 276


>UniRef50_P27616 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=32
           Tax=cellular organisms RepID=PUR7_YEAST
          Length = 306

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 49/258 (18%)

Query: 6   ELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            + RGK + +Y   +   L+    +  SA D         KG++  K + F    L+   
Sbjct: 14  LVARGKVRDIYEV-DAGTLLFVATDRISAYDVIMENSIPEKGILLTKLSEFWFKFLS-ND 71

Query: 66  IPTQMER----------------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVK 103
           +   +                         L D   LV K  ++P+E +VR    GS  K
Sbjct: 72  VRNHLVDIAPGKTIFDYLPAKLSEPKYKTQLEDRSLLVHKHKLIPLEVIVRGYITGSAWK 131

Query: 104 RL-------------GIEEGIELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLA 149
                          G++E  E   P+F    K +   HD  ++ +       V  +   
Sbjct: 132 EYVKTGTVHGLKQPQGLKESQEFPEPIFTPSTKAEQGEHDENISPAQAAE--LVGGDLSR 189

Query: 150 RMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK--GEVVLGDEF-SPDGSRLWDKETL 206
           R+ EL  K     K    + G+I+ D K EFG+ +   E++L DE  +PD SR W+  + 
Sbjct: 190 RVAELAVKLYSKCKDYAKEKGIIIADTKFEFGIDEKTNEIILVDEVLTPDSSRFWNGASY 249

Query: 207 ------EKMDKDRFRQSL 218
                 +  DK   R  L
Sbjct: 250 KVGESQDSYDKQFLRDWL 267


>UniRef50_Q73PW0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Treponema denticola RepID=Q73PW0_TREDE
          Length = 316

 Score =  215 bits (548), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 59/249 (23%), Positives = 97/249 (38%), Gaps = 36/249 (14%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            GK +  YS E    L+    +  SA D         KG V N+ + +      +  I  
Sbjct: 20  TGKVRDWYSPEEGKRLI-VTTDRISAFDRVL-TALPYKGQVLNQLSLWWFENTKDI-IKN 76

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEEG 110
            +         +V ++  +P+E +VR    G    +L  R               G+++ 
Sbjct: 77  HIISCPDPNCIIVTEVKPLPIEVIVRGYITGVTSTALWYRYSLGERNIYGYDFPEGLKKN 136

Query: 111 IELNPPLFDLFLKN-DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDA 169
             L  P+     K     HD  +      + G++SKE    +++      +  +K   +A
Sbjct: 137 QALPKPIITPTTKGGPTGHDERLTCDEVVSQGYLSKEQWDFVQKAALALFERGQKSAKEA 196

Query: 170 GLILVDFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLEK----------MDKDRFRQS 217
           GLILVD K EFG+ K   ++L DE  +PD SR W  +T E+           DK+  R  
Sbjct: 197 GLILVDTKYEFGVDKNNNILLIDEVHTPDSSRYWKLDTYEQRLKEGKEPENFDKEFVR-- 254

Query: 218 LGGLIEAYE 226
           +    + Y 
Sbjct: 255 MAYAAKGYR 263


>UniRef50_B0U1N3 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=21
           Tax=Proteobacteria RepID=PUR7_XYLFM
          Length = 308

 Score =  213 bits (544), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 54/257 (21%), Positives = 89/257 (34%), Gaps = 48/257 (18%)

Query: 10  GKAKTVYSTEN---------PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           GK + V+              + L++   +  SA D    +    KG +  + + F   K
Sbjct: 19  GKVRDVFDIPRKRLPVDTRSGEYLLIVATDRLSAFDVVLPDPIPGKGEILCQISNFWFQK 78

Query: 61  LAEAGIPTQMER--------------LLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL- 105
                +P  +                L +    + KKL  V +E + R    GS  K   
Sbjct: 79  TEHL-MPNHLTGINVASVLPDGIDKTLYTQRAVVTKKLKPVGIEAIARGYLIGSGWKDYQ 137

Query: 106 ------------GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARMK 152
                       G++E  +L  P+F    K     HD  ++         +  E   R++
Sbjct: 138 RTGKVSGIQLPDGLQEAEKLPDPIFTPSTKAAVGHHDENIDFDTTVKM--IGAELAERVR 195

Query: 153 ELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE--- 207
           + T +      K   + G++L D K EFG    G + + DE  +PD SR W  +  +   
Sbjct: 196 DATLRIYHFAAKYAAECGILLADTKFEFGTDIDGRLYVMDEMLTPDSSRYWPIDEYQVGT 255

Query: 208 ---KMDKDRFRQSLGGL 221
                DK   R  L  L
Sbjct: 256 SPPSYDKQFVRNYLETL 272


>UniRef50_UPI000187DCD8 hypothetical protein MPER_11578 n=1 Tax=Moniliophthora perniciosa
           FA553 RepID=UPI000187DCD8
          Length = 297

 Score =  213 bits (543), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 56/245 (22%), Positives = 88/245 (35%), Gaps = 34/245 (13%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             + +GK + +YST + D L+    +  SA D         KG +  + + F   KL   
Sbjct: 12  TLVSKGKVRNIYSTSSTDHLLFVATDRISAYDVILKNGIPDKGKLLTQISLFWFKKLGNI 71

Query: 65  GIPTQME---------------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVK--RLGI 107
            IP                     L D   LV+K  ++ +E +VR    G +        
Sbjct: 72  -IPNHFVTADIDEMPEQVRKYKDQLKDRTMLVRKAKVIQIEAIVRGYLTGEIWLGPEYQK 130

Query: 108 EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
           + G  +  PL     ++   HD   +         + +    ++ + + +          
Sbjct: 131 DRGQSMGSPLPTKHGRSKGAHDENFSPEQAV--KLLGQVLYDKVSQASLELYSEAASYAH 188

Query: 168 DAGLILVDFKLEFGLY-------KGEVVLGDEF-SPDGSRLWDKETLE------KMDKDR 213
             GLIL D K EFGL        + E++L DE  +PD SR W  E  E        DK  
Sbjct: 189 SRGLILADTKFEFGLIPSTSKPGEEELILVDEVLTPDSSRYWPLEGYEPGKTQPSFDKQY 248

Query: 214 FRQSL 218
            R  L
Sbjct: 249 LRNWL 253


>UniRef50_C7NLA9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Kytococcus sedentarius DSM 20547 RepID=C7NLA9_KYTSD
          Length = 336

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 62/282 (21%), Positives = 102/282 (36%), Gaps = 61/282 (21%)

Query: 4   QAELYRGKAKTVYSTE----------NPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKF 53
              ++ GK + +Y+              ++L++   +  SA D       + KG V  + 
Sbjct: 24  YELVHAGKVRELYAPGPDAPLPGGFAADEVLLMVASDRISAYDHVLSTPIEDKGEVLTRM 83

Query: 54  NYFIMSKLAEAGIPTQME--------RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL 105
           + +   +LA+  +P  +           ++    LVK+L M+PVECV R    G  +   
Sbjct: 84  SLWWFDQLADL-VPHHVLATEAPLVPEQVAGRAVLVKRLRMLPVECVARAHLTGGGLSEY 142

Query: 106 -------------GIEEGIELNPPLFDLFLKNDAM-HDPMVNESYCETFGWVSKENLARM 151
                        G+ +G EL  P+F    K  A  HD  ++     T   + +      
Sbjct: 143 RRAGTVSGVRLREGLVDGDELPDPIFTPSTKAPAGEHDEPISYEQVVTT--IGEPLARAA 200

Query: 152 KELTYKANDVLKKLFDDAGLILVDFKLEFG-----------------LYKG--EVVLGDE 192
           + LT        ++    G+I+ D K+EFG                 L  G   +VL DE
Sbjct: 201 RNLTVAILRRGHEVAAGRGIIVADTKVEFGLEGVEAERDLRTVTQKELDAGSVRIVLADE 260

Query: 193 F-SPDGSRLWDKETLE------KMDKDRFRQSLGGLIEAYEA 227
             +PD SR W  E  E        DK   R  L      ++ 
Sbjct: 261 VLTPDSSRFWPAEGFEAGRQQPSFDKQYVRDWLTSPASGWDK 302


>UniRef50_D0LZ80 Phosphoribosylaminoimidazolesuccinocarboxamidesy nthase n=1
           Tax=Haliangium ochraceum DSM 14365 RepID=D0LZ80_HALO1
          Length = 331

 Score =  209 bits (533), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 55/249 (22%), Positives = 96/249 (38%), Gaps = 39/249 (15%)

Query: 10  GKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQ 69
           GK +  Y   +   +V+   +  SA D         KG V N+   +   + A+   P  
Sbjct: 32  GKVRDSYVRGDQRTIVV--TDRLSAFDRVL-GTIPYKGQVLNQLAAYWFEETADIA-PNH 87

Query: 70  MERLLSDTECLVKKLDMVPVECVVRNRAAG----SLVKRL--------------GIEEGI 111
           + R+      +V+++  +  E VVR+   G    S+ +                G+ +  
Sbjct: 88  VVRVPDPNVMVVREVTPLRAEFVVRSYLTGVTSTSIWRAYESGARTFCGHALPEGMHKNQ 147

Query: 112 ELNPPLFDLFLKND-AMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAG 170
            L  P+     K     HD  V+       G +++E+  R  E+  K     ++   + G
Sbjct: 148 PLPEPILTPSTKAPQGEHDISVSREELLASGVITEEHFDRAGEIAMKLFAFGQQRAAERG 207

Query: 171 LILVDFKLEFGLY-----KGEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRF 214
           LIL D K E G+      + E+++ DE  +PD SR W  E  E           +DK+  
Sbjct: 208 LILADTKYEMGVAKNAAGEDEILVIDEIHTPDSSRYWHAEDFETRVKAGQEPRSLDKEYV 267

Query: 215 RQSLGGLIE 223
           R+ L    +
Sbjct: 268 RRWLAEERD 276


>UniRef50_A8GML2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=16
           Tax=Proteobacteria RepID=PUR7_RICAH
          Length = 236

 Score =  209 bits (532), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 72/235 (30%), Positives = 121/235 (51%), Gaps = 5/235 (2%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
            + ++Y+G +K +YS E   LL++ F ++     G  IE    KG++NN  + F+M KL 
Sbjct: 1   MKTQIYKGSSKILYSAEEDFLLIMAFSDNGILESGEIIE-VSGKGVLNNNISSFLMDKLE 59

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             GI       ++  E L++ +++ PV+ ++ + A G  VK  G++EG   + P+ D  +
Sbjct: 60  MIGIENHFIEKINMREQLIQYVEVFPVQVIISSVACGRFVKEFGMDEGYVFDKPIIDFKV 119

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
           ++     P+VNE     F W++ + +  +KE   +    L  LF   G+ LV+ KLEFG 
Sbjct: 120 RSREFKYPIVNEYQILNFSWLTLDEIKAVKEQALRIYAFLSGLFMGVGIRLVECKLEFGR 179

Query: 183 Y-KGE---VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLG 233
              GE   ++L DE SPD  RLW   + EK+  +          E+Y+ +A RL 
Sbjct: 180 VLNGEESIIMLTDEISPDNCRLWHIHSNEKLGFELLENKPNKAFESYQLIADRLK 234


>UniRef50_B3V647 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=uncultured marine crenarchaeote KM3-153-F8
           RepID=B3V647_9ARCH
          Length = 282

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 69/244 (28%), Positives = 106/244 (43%), Gaps = 23/244 (9%)

Query: 4   QAELYRGKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
            + + +GK K  Y S  NPD ++ +F +  SA D         KG     F  F    L 
Sbjct: 8   YSLIKQGKVKAAYESPSNPDTIMFDFSDRISAFDVVIPTDIPEKGKNLRDFAKFFFDNL- 66

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEE---------GIEL 113
              +P  + + +  T+ +VKKLD++PVEC+VR    G L  R+   E           +L
Sbjct: 67  --DVPHHLIKTVGSTKMIVKKLDVIPVECIVRGYLYGGLFDRVNNGEIEIDCDNVLATKL 124

Query: 114 NPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
           + P+FD   K+D + D  + ES   +   VS+E L  +K  +      +  +   +G ++
Sbjct: 125 SEPIFDPTTKSD-IKDEPITESEIISQKIVSEEELNYLKNTSIDIYKKILDMASKSGFLI 183

Query: 174 VDFKLEFGLYK-GEVVLGDEFSPDGSRLWDKETL------EKMDKDRFRQSLGGLIEAYE 226
            D KLEFG  + G ++L D   PD  RLW           E  DK   R  L  +   Y+
Sbjct: 184 ADLKLEFGKDESGNILLADSIGPDEFRLWSLAKYEVGKIQESYDKQILRDWL--IDSGYK 241

Query: 227 AVAR 230
               
Sbjct: 242 KQLD 245


>UniRef50_A5CCM2 Phosphoribosylaminoimidazole-succinocarboxamidesynthase n=2
           Tax=Orientia tsutsugamushi RepID=A5CCM2_ORITB
          Length = 252

 Score =  207 bits (528), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 63/235 (26%), Positives = 120/235 (51%), Gaps = 6/235 (2%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE 63
           + +++ G +K +Y  +    L+  F++D    +  ++ Q   KG++NN  + +I  +++ 
Sbjct: 14  KEKIFEGNSKIIYRIDEH-TLIQFFKDDMR-INAEKVIQVSGKGVLNNVISNYIFKRVSM 71

Query: 64  AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFLK 123
            GI   + + ++  E L+  L+++PV+  + N A+G  V + GIE+G   + P+ D  +K
Sbjct: 72  VGINHHLIQKINMREQLIYTLNIIPVKVCITNIASGRYVSQFGIEDGYVFDTPIIDFMVK 131

Query: 124 NDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY 183
           + A + P++NE     F WV    L  +K L  K    L  +F    + LV+ +LEFG  
Sbjct: 132 HGANNYPIINEDQMIKFNWVDYYELKNIKTLALKLYTFLVGMFASINIRLVECQLEFGRI 191

Query: 184 KG----EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVARRLGV 234
                  ++L DE +PD  +LWD ++  K+  +R    L   I  Y+ + +R  +
Sbjct: 192 NNLSGDIILLADEITPDTCKLWDLQSNCKLGYERACAELDNAIMFYKEIIKRFNL 246


>UniRef50_Q9P9D8 SAICAR synthase n=1 Tax=uncultured marine group II euryarchaeote
           37F11 RepID=Q9P9D8_9EURY
          Length = 301

 Score =  206 bits (524), Expect = 6e-52,   Method: Composition-based stats.
 Identities = 64/250 (25%), Positives = 107/250 (42%), Gaps = 38/250 (15%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
               LY+GK K V+ST++PD+L   F N  S  D        RKG   N+        + 
Sbjct: 1   MGEMLYQGKVKQVWSTDDPDILEFRFTNQISVFDQIIPSLIPRKGESLNRTTAHWFKLVE 60

Query: 63  EAGI-PTQMERLLSDTECLVKKLDM---------------VPVECVVRNRAAGSLVKRLG 106
           + G+  T +  L +   CLV+K+++               VP+E +VR+  +GS  +R  
Sbjct: 61  QEGVCGTHLVELNAPDRCLVRKVEVVKEPGAIPRDAEWVFVPLEFIVRHYLSGSAWRRFQ 120

Query: 107 --------------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMK 152
                          E G++L+ P  ++  K +A  D  ++         ++ +    + 
Sbjct: 121 RGELTAESLGVSQDAEYGVKLSEPFVEVTTKFEAF-DRNIDREEALQISNITDQEFDSIV 179

Query: 153 ELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE-VVLGDEF-SPDGSRLWDKETLE--- 207
           +   K ++++++     GLI VD K EF L  G  VVL D F + D  R WD E      
Sbjct: 180 QAALKVDEIIEREAAKNGLIHVDGKKEFALGPGRKVVLVDTFGTLDEDRWWDAEAYSNGE 239

Query: 208 --KMDKDRFR 215
             ++ K+  R
Sbjct: 240 CIELSKEFVR 249


>UniRef50_B3T553 Putative SAICAR synthetase n=2 Tax=prokaryotic environmental
           samples RepID=B3T553_9ZZZZ
          Length = 314

 Score =  201 bits (512), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 57/254 (22%), Positives = 103/254 (40%), Gaps = 40/254 (15%)

Query: 1   MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           M     +Y GK K V+ST++PD++   + +  S  D        RKG   N+ +      
Sbjct: 10  MCMGEMIYHGKVKQVWSTDDPDIIEFRYTDQISVFDQIIPSLVPRKGESLNRTSCHWFEL 69

Query: 61  LAEAGI-PTQMERLLSDTECLVKKLDMV---------------PVECVVRNRAAGSLVKR 104
           + + G+  T +  + +      ++ D++               P+E + R+  AGS  +R
Sbjct: 70  VEKEGVCDTHVIEMNAPDRVRARRFDVIREAGAITPDAENVFVPLEVICRHYLAGSGWRR 129

Query: 105 LG----------------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENL 148
                             + EG++L  P  ++  K +   D ++          +S E  
Sbjct: 130 YARGDVGAEEFGFEPGTVLTEGVKLPKPYLEVSTKFEKF-DRLLGREEALEISNLSDEEF 188

Query: 149 ARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKG-EVVLGDEF-SPDGSRLWDKETL 206
             + E+  K ++++++    +GLI VD K EF L  G   VL D F + D  R WD    
Sbjct: 189 DSILEIVLKVDEIIEREAAKSGLIHVDGKKEFALGVGRRPVLVDSFGTLDEDRWWDAAAY 248

Query: 207 E-----KMDKDRFR 215
           E     ++ K+  R
Sbjct: 249 ERGEIVQLSKEFVR 262


>UniRef50_B3DVV2 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase
           n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DVV2_METI4
          Length = 297

 Score =  198 bits (505), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 63/247 (25%), Positives = 97/247 (39%), Gaps = 31/247 (12%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            ++  GK + +Y  +N   L +   +  SA D    E+   KG+V N+       + +  
Sbjct: 13  RKVRSGKVRDLYHWKNE--LWMVTSDRVSAFDCVLAEEIPSKGIVLNQIALGWFERTSVI 70

Query: 65  GIPTQMERLL----------SDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------- 105
             P+ +                    V   D +PVE + R    G   K           
Sbjct: 71  C-PSALLSEELPLEIDLPEWEGRLMRVLPCDPLPVEFIARGYVVGGAWKEYLEKGTAGGY 129

Query: 106 ----GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDV 161
               G+  G  L  PLF    K    HD  ++E   +    +  EN   +K LT +    
Sbjct: 130 KLPRGLTYGSPLPEPLFTPTTKAKQGHDLPLDEESAKE--IIG-ENYELLKNLTLELYLH 186

Query: 162 LKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETLEKMDKDRFRQSLGG 220
            K    + GLIL+D K EFG+ +G++ L DE  +PD SR W +E  E+ DKDR       
Sbjct: 187 GKSYAFNKGLILLDTKFEFGIREGKIFLIDELMTPDSSRFWLREDFER-DKDRCPHYDKQ 245

Query: 221 LIEAYEA 227
           ++  Y  
Sbjct: 246 ILRHYLE 252


>UniRef50_C7M1W2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Acidimicrobium ferrooxidans DSM 10331
           RepID=C7M1W2_ACIFD
          Length = 292

 Score =  195 bits (497), Expect = 9e-49,   Method: Composition-based stats.
 Identities = 57/234 (24%), Positives = 90/234 (38%), Gaps = 28/234 (11%)

Query: 10  GKAKTVY-STENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
           GK +  +    +   L++   +  SA D    E    KG +          ++A   + T
Sbjct: 9   GKVRETWVDPRDEAALLVVATDRVSAFDVVLPELVPDKGRLLTAIAAAAFERVAS-DVAT 67

Query: 69  QMERLLSD-------TECLVKKLDMVPVECVVRNRAAGSLVKRLG-------------IE 108
            +  + +D           V++L M+PVECVVR R  GS  +                ++
Sbjct: 68  HLLEVATDVPDVWLGRTLRVRRLAMLPVECVVRGRLVGSAWESYQRDGTAFGRELPRDLD 127

Query: 109 EGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDD 168
            G     PLF    K    HD  +          V +     + + + +   +L   FD 
Sbjct: 128 FGAPFPEPLFTPTTKAHVGHDLPLGPDELGE--LVGERRARELADRSLEVFSLLASWFDA 185

Query: 169 AGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEK---MDKDRFRQSL 218
            GL LVD K EFGL    +VL DE  +PD +R+   +  +    +DK   R  L
Sbjct: 186 KGLTLVDAKFEFGLDGRALVLADEIATPDAARIVAGDLGQNPQWLDKQLLRDWL 239


>UniRef50_Q9HLC0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=Euryarchaeota RepID=PUR7_THEAC
          Length = 294

 Score =  193 bits (490), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 62/262 (23%), Positives = 111/262 (42%), Gaps = 39/262 (14%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             + +GK K VY  ++ D LV  F N  S  D     + + KG    + + F    + E 
Sbjct: 2   KIIAKGKVKDVY--DDGDTLVFRFSNRISVFDKIIPTEIENKGESLCRTSSFWFRYIGER 59

Query: 65  GIPTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRLG------ 106
           GI      ++ +    V+K D            ++P+E + R+  AGSL  RL       
Sbjct: 60  GIKNHFIEMIDNRTMRVRKYDVPEKVSPGSSGYVIPLEFITRHYVAGSLYDRLKAGSTKP 119

Query: 107 --------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                    + G +L  P+F++  K +   D +++         +++E  A ++E   K 
Sbjct: 120 ADIGLNHFPDYGEKLPSPVFEVTTKREKT-DRLLDIDEALEISGLTREEYAEIRETILKI 178

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE-----KMDK 211
           ++++++     GLI  D K E  L  + E ++ D F + D  R W+K+  +     ++ K
Sbjct: 179 DEMMEQEVGKRGLIHADGKKEVALGKEREPIIVDTFGTADEDRFWEKKEYDAGRIVELSK 238

Query: 212 DRFRQS---LGGLIEAYEAVAR 230
           +  RQ     G     YEA +R
Sbjct: 239 EMVRQYYRSTGYHDRLYEARSR 260


>UniRef50_Q94IQ2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Alveolata RepID=Q94IQ2_CRYCO
          Length = 522

 Score =  192 bits (488), Expect = 8e-48,   Method: Composition-based stats.
 Identities = 51/215 (23%), Positives = 86/215 (40%), Gaps = 21/215 (9%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            GK + +Y       +V+   +  SA D         KG V    + +   +  +  +P 
Sbjct: 38  SGKVRDIYFA--GKNVVMVTNDRVSAFDFILPNLIPFKGQVLCGISEWAFQETKDI-VPN 94

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL--------------GIEEGIELN 114
            +   +  +  + KK+  + VE +VR    GS+                  G+    + +
Sbjct: 95  ALIENVDSSVVVQKKMTNLNVEFIVRGYLWGSMAAAYEKGDRTFCGLKVPDGLNRFQKFD 154

Query: 115 PPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILV 174
            PLF    K +  HD  +   Y E    + K+   + K++  K      +L    GLIL+
Sbjct: 155 EPLFTPTTKAEVGHDENMT--YAEVEKLIGKDMAKKAKDVAMKLYARGAELMRKRGLILI 212

Query: 175 DFKLEFGLYK-GEVVLGDEF-SPDGSRLWDKETLE 207
           D K EFGL + G + + DE  +PD SR+   E  E
Sbjct: 213 DTKYEFGLDEHGVLHVIDEVNTPDSSRMCTVEEWE 247


>UniRef50_UPI0001926A10 PREDICTED: similar to phosphoribosylaminoimidazole carboxylase,
           phosphoribosylaminoimidazole succinocarboxamide
           synthetase isoform 2 n=1 Tax=Hydra magnipapillata
           RepID=UPI0001926A10
          Length = 391

 Score =  190 bits (482), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 56/251 (22%), Positives = 99/251 (39%), Gaps = 53/251 (21%)

Query: 4   QAELYRGKAKTVYSTE---NPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
              +  GK K +Y+     +   ++++  +  + GDGAR +                   
Sbjct: 9   NDLIIEGKTKAIYALPEYLDGQYVIMKSHDQITCGDGARKDIL----------------- 51

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR-LGIEEGIELNPPLFD 119
                            EC+V++  M+P+E V R  A GS +KR  G+ EG   + P  +
Sbjct: 52  ----------------IECIVERCQMIPLEIVSRRLATGSYLKRNPGVNEGFRFSTPKME 95

Query: 120 LFLKNDAMHDPMVNESYCETFGW------VSKENLARMKELTYKANDVLKKLFDDAGLIL 173
            F K+DA HDP  +               + +  L  +  +     ++L+K +     +L
Sbjct: 96  YFFKDDANHDPQWSSDQILENKLMIGGLTIGQFELDEITLVAKTCFEILEKAWASRNCVL 155

Query: 174 VDFKLEFGLY--KGEVVLGDEFSPDGSRLWDKETLEKM-DKDRFRQ-------SLGGLIE 223
           VD K+EFG+     E+VL D    D  R+W       M DK  +R        ++  + +
Sbjct: 156 VDMKVEFGVTIKNKEIVLADVIDNDSWRIWPAGDKRLMKDKQVYRNLSVVTTEAMSEIRK 215

Query: 224 AYEAVARRLGV 234
            Y  V+  + +
Sbjct: 216 NYTWVSNEVKL 226


>UniRef50_Q978V1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Thermoplasmatales RepID=PUR7_THEVO
          Length = 294

 Score =  187 bits (476), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 59/257 (22%), Positives = 102/257 (39%), Gaps = 39/257 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L  GK K VY  ++ D LV +F N  S  D     + D KG    + + F    +   
Sbjct: 2   KLLTTGKVKDVY--DDGDTLVFKFSNRISVFDKIIPNEIDNKGESLCRTSAFWFQLIESY 59

Query: 65  GIPTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRLG------ 106
           G+ +    L+ +    V+K              ++P+E + R   AGSL  R+       
Sbjct: 60  GMKSHFIELIDNRTMRVRKFAVPNKVSLGSSNYVIPLEFITRYYVAGSLYDRIKEGKVKP 119

Query: 107 --------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                    E G +L  P+F+   K +   D ++ +      G ++ E+   + E  +K 
Sbjct: 120 MDIGLKHVPEYGEKLIDPIFEATTKREET-DRLLTKKEAMEIGGLTLEDYCEIMEAVFKI 178

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE-----KMDK 211
           +  +       GLI  D K E  L  +  +V+ D F + D  R WD++  +     ++ K
Sbjct: 179 DRRIDMEVSKRGLIHADGKKEIALDRERRIVVVDTFGTADEDRFWDEKEYDNGRVVELSK 238

Query: 212 DRFRQS---LGGLIEAY 225
           +  RQ    +G   + Y
Sbjct: 239 EMVRQYYRSIGYHDKLY 255


>UniRef50_Q83GX1 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Tropheryma whipplei RepID=PUR7_TROWT
          Length = 305

 Score =  185 bits (469), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 49/247 (19%), Positives = 92/247 (37%), Gaps = 42/247 (17%)

Query: 10  GKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAE----- 63
           GK + +Y      ++L++   N  SA D     +   KG +  + + +   KL       
Sbjct: 22  GKVRELYVHRQYKNILLMFASNRVSAFDFVLEPEIPEKGRMLTQMSNWWFRKLPAENHLL 81

Query: 64  --------AGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------- 105
                     + + +   + +   + +K+D++P E V+R    GS               
Sbjct: 82  ENYDQELYRDLASHIPSHILERSTICRKMDIIPFEFVIRGYLTGSAWADYLENNTVYGIK 141

Query: 106 ---GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
                 +G  L  P+F    K+     P+  E      G     +  +++E+        
Sbjct: 142 LKGKFRQGDRLPGPIFTPTTKSRTKDTPVRYEDLVNAIGL---SHAQQLREMCTDYYTTA 198

Query: 163 KKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL-----------EKMD 210
           +++  + GLI+ D K EFG+ +G+V L DE  + D +R WD  +            +  D
Sbjct: 199 EQIARNKGLIIADAKFEFGIAEGKVYLADELLTADSARYWDINSWGQFDLPIERRLDSFD 258

Query: 211 KDRFRQS 217
           K   R  
Sbjct: 259 KQAVRDW 265


>UniRef50_UPI000038E095 phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E095
          Length = 296

 Score =  185 bits (469), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 64/258 (24%), Positives = 103/258 (39%), Gaps = 39/258 (15%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
             L +GK K VY  ++   LV +F +  S  D    +    KG    + + +  + ++  
Sbjct: 4   ELLRKGKVKDVY--DDGKDLVFKFSDRISVFDKIIPDSIPHKGESLCRTSTYWYNIVSSL 61

Query: 65  GIPTQMERLLSDTECLVKKLD------------MVPVECVVRNRAAGSLVKRL------- 105
           GI T    L+SD+E  VKK              MVP+E + R   AGS   R+       
Sbjct: 62  GIDTDFIELVSDSEMKVKKFRQIDRGYKFLSNYMVPLEFITRYYLAGSAYDRVKSGEIDY 121

Query: 106 -------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                      G +L  P F++  K +     +  +   E  G      L  ++E  +K 
Sbjct: 122 HSLGFKNPPVYGEKLPDPFFEVSTKFEKFDRYLHTDEALEISGL-DAGELCEIQETIFKI 180

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEF-SPDGSRLWDKETLE-----KMDK 211
           +  +    +  GLI  D K EF L  + + V+ D F + D  R WDK+  E     ++ K
Sbjct: 181 DRRINSSVESRGLIHADGKKEFALGLERKPVIIDTFGTLDEDRFWDKKDYENGQVNELSK 240

Query: 212 DRFRQS---LGGLIEAYE 226
           +  RQ     G   + Y+
Sbjct: 241 EMVRQYYRKTGYHQKLYD 258


>UniRef50_C5A6A8 Phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase
           (PurC) n=1 Tax=Thermococcus gammatolerans EJ3
           RepID=C5A6A8_THEGJ
          Length = 219

 Score =  184 bits (468), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 60/203 (29%), Positives = 93/203 (45%), Gaps = 9/203 (4%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDG-------ARIEQFDRKGMVNNKFNYFI 57
             +Y GK K VY  E+   LV  F++     DG         I +   KG +  +   F 
Sbjct: 2   RLVYSGKTKDVY--EDGPYLVFHFKDTVLGRDGREDSGGNEVIGEKTGKGSLVLEQTEFF 59

Query: 58  MSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPL 117
              L   G+ T     +   +    + + +P+E + R  A GS ++R            +
Sbjct: 60  FRLLEGNGVKTHFVERIDGRKARFLRAEKIPLEVIYRELAYGSFLRRYKGWAKPFQRLGI 119

Query: 118 FDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFK 177
            +  LK+D++ DP++ E      G  S+E +  MKE T K   +L++ F   GL LVDFK
Sbjct: 120 VEFTLKDDSLDDPLIAEEAIVVLGIASEEEVEVMKEKTRKVAGILREFFSSKGLQLVDFK 179

Query: 178 LEFGLYKGEVVLGDEFSPDGSRL 200
           LEFG   GE+++ DE S D  R+
Sbjct: 180 LEFGRLDGELIVIDELSRDTMRV 202


>UniRef50_B8J393 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=3
           Tax=Proteobacteria RepID=B8J393_DESDA
          Length = 234

 Score =  184 bits (467), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 64/234 (27%), Positives = 101/234 (43%), Gaps = 23/234 (9%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTS---------AGDGARIEQFDRKGMVNNKFNY 55
             +YRGK K VY     D L L F +  +          G+         +G        
Sbjct: 2   NLVYRGKTKDVYDNGE-DGLRLIFSDRVTKNAAGEIDPGGNTVAENTEPGQGEACLLMAS 60

Query: 56  FIMSKLAEA-GIPTQMERL-LSDTECLVKKLDMV--PVECVVRNRAAGSLVKRLGIE--- 108
            I  +LAE  G+ T M    L      V++  M    +E + R    GS ++R G+    
Sbjct: 61  AIFEELAEKNGVSTHMIAYDLPSLSMDVRRGTMFNPGIEWIARWVCTGSFLRRYGMVPGV 120

Query: 109 -EGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD 167
            +G+    P+F++ LK+DA  DP+V  S     G V    +  + +   KA   ++ +F 
Sbjct: 121 YDGMRFADPVFEITLKDDAAGDPLVVPSALVALGVVDARTMTALLDSNAKAMQAIQAMFA 180

Query: 168 DAGLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKMD----KDRFRQ 216
              L L D K+E+ L  KG  +L DE SP   R +D +T +++      +RFR+
Sbjct: 181 ARDLDLWDIKIEWALDAKGAPMLIDEVSPGCCRAFDMKTKKRVSGIALAERFRR 234


>UniRef50_B2A872 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=4
           Tax=cellular organisms RepID=B2A872_NATTJ
          Length = 226

 Score =  179 bits (455), Expect = 6e-44,   Method: Composition-based stats.
 Identities = 59/222 (26%), Positives = 105/222 (47%), Gaps = 14/222 (6%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSA-------GDGARIEQFDRKGMVNNKFNYFI 57
            ++Y GK K V+       LVL F+++ +        G    + +   KG+ +     + 
Sbjct: 2   KQIYEGKTKKVF-LNEKGNLVLYFKDEVTGTGEDIDPGGNEVVGEIPEKGLSSLAVTKYF 60

Query: 58  MSKLAEAGIPTQME-RLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG-IEEGIELN- 114
              L E GIPT        +    V++ + + +E + R +A GS ++R     +  EL  
Sbjct: 61  FDMLKEKGIPTHFIDASPEEGYMEVQQCEALGLEVICRVKAYGSFLRRYPEFTQNKELEH 120

Query: 115 -PPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
              L ++ +K+D   DP++N+      G ++ E L  MKE+T     +++   +D GL L
Sbjct: 121 LNYLVEVTVKDDERGDPLINDEALIKLGILNNEELDSMKEITKSVAKIIETELNDKGLDL 180

Query: 174 VDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKMDKDRF 214
           +DFKLEFG    G++++ DE S D  R++ K+      K+  
Sbjct: 181 IDFKLEFGRVKDGKIIIIDEISGDSMRVF-KDDKTVTQKELV 221


>UniRef50_C7RD67 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=18
           Tax=Bacteria RepID=C7RD67_ANAPD
          Length = 226

 Score =  176 bits (446), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 58/215 (26%), Positives = 97/215 (45%), Gaps = 15/215 (6%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQ-------FDRKGMVNNKFNYFI 57
            ++Y GK K VY     + L+ +F++D +  DG             +  G        F 
Sbjct: 2   EKVYTGKTKDVYKLNEEEYLL-KFKDDVTGNDGVFDPGANSVGLTMEGAGHQAVAMTKFF 60

Query: 58  MSKLAEAGIPTQME-RLLSDTECLVKKLDMVP--VECVVRNRAAGSLVKRLG--IEEGIE 112
             KL + G+ T      L   E +VKK ++    VE +VR  A GS ++R G  IE G +
Sbjct: 61  YEKLNDKGLTTHFISADLDKNEAIVKKAEVFGQGVEVIVRYYAVGSFIRRYGKYIESGTK 120

Query: 113 LNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLI 172
           ++ P  ++ LK+D   DP++ +      G +++E    +K+L     +++++      L 
Sbjct: 121 ID-PYVEITLKDDEREDPLITKDALVLLGIMTEEEYEELKDLALNIGEIVREELGKKDLD 179

Query: 173 LVDFKLEFGL-YKGEVVLGDEFSPDGSRLWDKETL 206
           L D K EFG    G+V L DE S    R +  +  
Sbjct: 180 LYDIKFEFGRIEDGKVALIDEISGGNMRAYKGDKY 214


>UniRef50_Q895U7 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=12
           Tax=cellular organisms RepID=PUR7_CLOTE
          Length = 227

 Score =  169 bits (429), Expect = 6e-41,   Method: Composition-based stats.
 Identities = 56/225 (24%), Positives = 99/225 (44%), Gaps = 17/225 (7%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQ-------FDRKGMVNNKFNYFI 57
             +Y+GK K V+  E+ + L+ +F++D +  +G             +  G    +     
Sbjct: 2   NVVYKGKTKDVFLLEDGNYLL-KFKDDVTGENGVFDPGANSVGLTMEGAGRAALRLTKLF 60

Query: 58  MSKLAEAGIPTQME-RLLSDTECLVKKLDMVP--VECVVRNRAAGSLVKRLGI--EEGIE 112
             +L E  IPT      + +    VK   +    +E + R RA GS ++R G+  +EG  
Sbjct: 61  FERLKEEKIPTHYIDSNVEEGTMKVKPAKIFGNGLEVICRYRAVGSFMRRYGMYAKEGQV 120

Query: 113 LNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLI 172
           L+    ++ LK+D   DP + +   +  G +S      +K+LT K + ++K      G+ 
Sbjct: 121 LDA-FVEVTLKDDERQDPPITKDALDMLGILSLREYDILKDLTKKISGIVKDELSKKGIE 179

Query: 173 LVDFKLEFGLYKGE--VVLGDEFSPDGSRLWDKETL-EKMDKDRF 214
           L D KLEFG    +  + L DE S    R +      E +D ++ 
Sbjct: 180 LYDIKLEFGRIDEDNHIALIDEISGGNMRAYKDGEYIEPLDLEKL 224


>UniRef50_Q7MLF9 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=112
           Tax=cellular organisms RepID=PUR7_VIBVY
          Length = 367

 Score =  168 bits (426), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 53/278 (19%), Positives = 95/278 (34%), Gaps = 60/278 (21%)

Query: 1   MQKQAELYRGKAKTVYSTENPD-----------------LLVLEFRNDTSAGDGARIEQ- 42
           ++    ++ GK ++VY     D                 L ++   +  SA D     + 
Sbjct: 16  IRTDKPVHSGKVRSVYWLTEEDSARLIKEKGYNVAPDAPLAIMVISDRISAFDCIWHGEH 75

Query: 43  ----FDRKGMVNNKFNYFIMSKLAEAGIP-TQMERLLSDTECLVKKLDMVPVECVVRNRA 97
                  KG   N  +        E G+  + +  +      +V+K   V +E + R   
Sbjct: 76  GLNGVPGKGAALNAISNHWFGLFKENGLADSHILDIPHPFVWIVQKAKPVKIEAICRKYI 135

Query: 98  AGSLVKRL--------------GIEEGIELNPPLFDLFLKN--------DAMHDPMVNES 135
            GS+ +                G+E+   L   L     K             D  +   
Sbjct: 136 TGSMWRAYEKGEREFCGIQLPEGLEKDKALPDLLMTPSTKGILKGIPGVPEADDVNITRQ 195

Query: 136 YC----ETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-----KGE 186
                   F + S +++A  ++L      V+ +   + G I VD K EFG         +
Sbjct: 196 NIADNFAAFNFSSADDIALYEKLLKDGFGVISEALANVGQIFVDTKFEFGYVTDAAGNEK 255

Query: 187 VVLGDEF-SPDGSRLWDKETLE-----KMDKDRFRQSL 218
           ++  DE  +PD SR+WD +  +     +  K+ FRQ L
Sbjct: 256 LIYMDEVGTPDSSRIWDAQEYQAGKIVENSKEGFRQFL 293


>UniRef50_Q466M0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=3
           Tax=Archaea RepID=Q466M0_METBF
          Length = 296

 Score =  165 bits (419), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 66/288 (22%), Positives = 103/288 (35%), Gaps = 65/288 (22%)

Query: 7   LYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGI 66
           + +GK K +      + + LE RN  + GD AR E     G+        I S L   G+
Sbjct: 3   ISQGKTKVILPGPRKNTVFLETRNVLTGGDAARRETIAGIGIHKTTQAANIFSLLNRKGL 62

Query: 67  PTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKR---LGIEEGI--ELNPPLFDLF 121
           PT      S    L  + +M+P+E VVR  A GS ++R    G +EG     + P++++F
Sbjct: 63  PTAFIERTSPNTLLCYQCEMLPLELVVRRYAWGSYLQRHPEYGNQEGTAYRFDEPVWEIF 122

Query: 122 LKNDAMHDP------MVNESYCETFGWV-------------------------------- 143
            K   +  P       ++E                                         
Sbjct: 123 HKLSVVGFPVTDKPYQIDEEAAREQFLHNGIWQEGVYTDPYIQVDKNQWLLYPSKKELSK 182

Query: 144 -----------SKENLARMKELT-----YKANDVLKKLFDDAG-LILVDFKLEFG--LYK 184
                      S+E L  + +           D  +K+    G + LVD K+E G  L  
Sbjct: 183 SKPILSMKPACSQEELDYIVQAIMLPTFLALEDAWRKIMTTYGPMELVDLKIEVGRRLDN 242

Query: 185 GEVVLGDEFSPDGSRLWDKETLE-KMDKDRFRQS--LGGLIEAYEAVA 229
             +V+ D    D  R+W     E ++DK  FR    L  + E Y  +A
Sbjct: 243 NRIVIADVIDNDSWRIWSGGNPEKQLDKQCFRDGNPLDQVAENYATLA 290


>UniRef50_Q6NRP1 LOC431975 protein (Fragment) n=2 Tax=Xenopus RepID=Q6NRP1_XENLA
          Length = 371

 Score =  162 bits (411), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 45/218 (20%), Positives = 89/218 (40%), Gaps = 14/218 (6%)

Query: 1   MQKQAELYRGKAKTVYST-ENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMS 59
           ++   +L   +A  VY   E P  ++++ ++  +A   A     D K  V+NK    +  
Sbjct: 82  LKLGKKLREDEATEVYELSEQPGCVLIQSKDHINAQYTAWDGHKDTKASVSNKATSRVFI 141

Query: 60  KLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFD 119
            L EAGI T   +  S+   +  + +M+P+E   R    G   +    +EG   + P  +
Sbjct: 142 LLQEAGIKTAFVKRCSEAAFIATQCEMIPIEWFCRKIPTG---RNTETDEGYRFSQPKVE 198

Query: 120 LFLKNDAMHDPMVNESYCETFG------WVSKENLARMKELTYKANDVLKKLFDDAGLIL 173
           +  K D   +  +++              + K  +  M   T    ++++K +      L
Sbjct: 199 M-YKVDDTSNHQLSKEQLMAVKLICAGLLIGKMEVDVMTRSTIAIFEIIEKAWRAQDCTL 257

Query: 174 VDFKLEFGLY--KGEVVLGDEFSPDGSRLWDKETLEKM 209
           VD +++FG+   K E++L D        LW      ++
Sbjct: 258 VDMRIKFGVDVTKKEILLTD-IKCGSQALWPLGNKSQL 294


>UniRef50_A8M140 SAICAR synthetase n=1 Tax=Salinispora arenicola CNS-205
           RepID=A8M140_SALAI
          Length = 236

 Score =  157 bits (397), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 62/225 (27%), Positives = 90/225 (40%), Gaps = 14/225 (6%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            G++K V+    P   V+E      +    R E  D    +   F  ++   LA+AG+PT
Sbjct: 14  TGRSKKVWFV-EPGRCVVEMIPSLRSFTHDRDELMDGTAELRLDFFEYVSGVLAKAGVPT 72

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--IEEGIELNPPLFDLFLKNDA 126
                L     L      VP E +V+NRA GS  ++     EEG    PP+     + D 
Sbjct: 73  VFRERLGPITYLADYRPAVPFEVIVKNRATGSTTRKYPGLFEEGRVFAPPVVKFDYRTDP 132

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE 186
             D  + E Y    G     ++   + L    N VL  L     L L DF L     +  
Sbjct: 133 E-DQPIGEDYLRRTGV----DVEAYRRLALACNTVLHTLVSP--LELWDFCLVIAPDEER 185

Query: 187 -VVLGDEFSPDGSRLWDKETLEKMDKDRFRQSL--GGLIEAYEAV 228
            +V+  E SPD  RL   +  E  DKD FR+      +IE +  +
Sbjct: 186 GLVINSEISPDCMRLRRADG-EPYDKDLFRRGASREQIIERWTEL 229


>UniRef50_A4NXH0 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Haemophilus influenzae RepID=A4NXH0_HAEIN
          Length = 210

 Score =  156 bits (396), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 40/196 (20%), Positives = 78/196 (39%), Gaps = 29/196 (14%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA 64
            ++Y GK + +Y  ++   +++   +  SA D    +   RKG +  + + F  +KLA  
Sbjct: 11  KKIYSGKVRDLYEIDDK-RMLMVASDRLSAFDVILDDPIPRKGEILTQISNFWFNKLAHI 69

Query: 65  GIPTQM-------------ERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL------ 105
            +P                  L+ D   + K+L  + +E +VR    GS +K        
Sbjct: 70  -MPNHFTGESVYDVLPKEEADLIKDRAVVCKRLTPIKIESIVRGYLTGSGLKDYKQTGTI 128

Query: 106 -------GIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                  G+ E  +L   +F    K + + +  +N SY E    +  +  A++K+     
Sbjct: 129 CGLKLPEGLVEASKLPEAIFTPSSK-EEVGNHDINISYAECEKLIGSDLAAQVKKKLSHF 187

Query: 159 NDVLKKLFDDAGLILV 174
              L+ +    GL+ V
Sbjct: 188 IPWLQNMHSLKGLLFV 203


>UniRef50_A8M136 SAICAR synthetase n=1 Tax=Salinispora arenicola CNS-205
           RepID=A8M136_SALAI
          Length = 322

 Score =  156 bits (395), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 48/256 (18%), Positives = 91/256 (35%), Gaps = 45/256 (17%)

Query: 12  AKTVYSTE-----NPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEAG 65
            K ++  E          VL F +  S  D G   +    KG                AG
Sbjct: 6   TKDLHVLEPATGGRAGDAVLTFTDRYSVFDHGVMPDLIPGKGRATCAMAVLSFGLFERAG 65

Query: 66  IPTQMERLLSDTECLVK-------------KLDMVPVECVVRN--RAAGSLVKRLGI--- 107
           I T     +++    ++                ++P++ V R   R   S+ +R+     
Sbjct: 66  ITTHFVEQVAEDAIRIRLLGLDLTGSRRTGPAQLIPLQIVYRRQLRPESSVHRRVATGAV 125

Query: 108 ---------EEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKA 158
                     E   L+P + +   K +   D  ++ +     G +S  +L  + E   + 
Sbjct: 126 DPASIPPMEPETGRLDPVMVEFTSKFEET-DRFLDPAAATRVGHISPADLTGLTEQARRV 184

Query: 159 NDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE-FSPDGSRLWDKETLEKMDKDRFRQ 216
              + +     GL LVD K E+G  + G+++L D   +PD +R + ++T   + K+  R 
Sbjct: 185 CAAVDEHCVRVGLTLVDGKTEYGFDEHGDLMLVDHAGTPDENRFYFEDT--PVCKELLR- 241

Query: 217 SLGGLIEAYEAVARRL 232
                   Y  +  R+
Sbjct: 242 ------ALYPELRERV 251


>UniRef50_B5GV74 Saicar synthetase n=1 Tax=Streptomyces clavuligerus ATCC 27064
           RepID=B5GV74_STRCL
          Length = 238

 Score =  153 bits (388), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 59/230 (25%), Positives = 95/230 (41%), Gaps = 14/230 (6%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            G++K ++      L V+E      +   +R E  +  G +  +F     ++LA+ G+ T
Sbjct: 18  EGRSKRIWLLS-GGLCVVEMIPSLRSFTYSRDELVEETGPLRLEFYDRAAARLAKGGVRT 76

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLG--IEEGIELNPPLFDLFLKNDA 126
              R L+ T  L +  +  P E VV+NRA GS + +         EL  P+     + D 
Sbjct: 77  GFVRRLAPTVYLSEFHEAPPFEVVVKNRAVGSTLVKYPGLFPANSELPKPVVKFDYRIDP 136

Query: 127 MHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KG 185
             D  + E Y           +   + +    ND L        L + DF +  GL  +G
Sbjct: 137 E-DQPIGEDYLRALDLP----VEEFRRIALAVNDTLISWLAP--LEVWDFCIILGLDPQG 189

Query: 186 EVVLGDEFSPDGSRLWDKETLEKMDKDRFRQSL--GGLIEAYEAVARRLG 233
           E VL  E SPD  RL   +    +DKD FR       L+ A++ +   +G
Sbjct: 190 EPVLISEVSPDCMRLRHPDG-SSLDKDLFRHGASSEELVTAWQRLLDEIG 238


>UniRef50_Q6MIY7 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Bdellovibrio bacteriovorus RepID=Q6MIY7_BDEBA
          Length = 344

 Score =  151 bits (383), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 59/259 (22%), Positives = 93/259 (35%), Gaps = 54/259 (20%)

Query: 5   AELYRGKAKTVYSTENPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
             +YRG  K +Y  +N D +V E+ N  S  D G   ++   KG             L+ 
Sbjct: 2   NLIYRGSVKDLY--QNNDKIVFEYSNRYSIFDWGEMPDEIPHKGEALAAMASMFFEHLSA 59

Query: 64  AGIPTQMERLLSDTECLVKKLDMV-----------------------PVECVVR------ 94
            G  +      S T   V+ + ++                       P+E + R      
Sbjct: 60  RGFSSHYLSGRSRTSIEVQPVKVLRPEWKGEAYDYSMYASRPTQCLVPLEVIFRRHLGQG 119

Query: 95  NRAAGSLVKRLGIEEGIELN----------PPLFDLFLKNDAMHDPMVNESYCETFGWVS 144
           N   G L K       +EL+          P L ++  K +   D  ++++       V+
Sbjct: 120 NSLEGRLKKNPAYLADLELSKMPTSADSFMPALVEVSTKLETT-DRYLSKADVAAMNVVN 178

Query: 145 KENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-----KGEVVLGDEFSPDGSR 199
               A +++ T      L+KLF   G+ L D KLEF        +  +VL D   PD  R
Sbjct: 179 DAEYAALRKNTQDVAAELEKLFASFGVKLWDGKLEFAFTHENNGQRGLVLVDSIGPDELR 238

Query: 200 LWDKETLE--KMDKDRFRQ 216
           L    T E   + K+  RQ
Sbjct: 239 L----TYEGLPLSKEFLRQ 253


>UniRef50_D2RHF2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Archaeoglobaceae RepID=D2RHF2_ARCPR
          Length = 335

 Score =  150 bits (379), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 57/281 (20%), Positives = 98/281 (34%), Gaps = 66/281 (23%)

Query: 10  GKAKTVYSTENP-----DLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
           G  K +   E P           F +  S  D G   +  + KG      + +   KL +
Sbjct: 2   GSVKDLIVIEEPKEDKMGFADFVFSDRYSVFDYGVMPDLIEHKGESLCLISAYFFEKLED 61

Query: 64  AGIPTQMERLLSD-------------TECLVKKLDM----------------------VP 88
            GI T    L+ +                 VK   +                      +P
Sbjct: 62  YGIKTHYIGLVENGKVKRFDEISKPTNVMRVKLARVVKPEKKNGYDYSVFRKLKGNFLIP 121

Query: 89  VECVVRN-RAAGSLVKR-----------LGIE---EGIELNPPLFDLFLKNDAMHDPMVN 133
           +E + RN    GS + R            G++   EG++L  P+ D   K + + D  ++
Sbjct: 122 LEVIYRNSIPKGSSLLRRIKEGKVKPEDFGLKEIVEGMKLEKPIIDFSTKLEDV-DRYLS 180

Query: 134 ESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLGDE 192
               +    +S E   R+KE+  K ++++       GL   D K+EF L +   +++ D 
Sbjct: 181 HGEAKEISGLSDEEFERLKEIALKVDEIITSEVSKVGLENEDGKIEFALDEFRNIIVVDA 240

Query: 193 F-SPDGSRLWDKETLEKMD--KDRFRQSLGGLIEAYEAVAR 230
             +PD  R     + E  D  K+  R+      E YE +  
Sbjct: 241 VGTPDECRF----SYEGFDVSKELLREYYRK-TEWYERLKE 276


>UniRef50_A8EWL2 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=1
           Tax=Arcobacter butzleri RM4018 RepID=A8EWL2_ARCB4
          Length = 317

 Score =  149 bits (377), Expect = 7e-35,   Method: Composition-based stats.
 Identities = 61/269 (22%), Positives = 92/269 (34%), Gaps = 48/269 (17%)

Query: 4   QAELYRGKAKTVYS-TENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
               Y GK   +YS       ++L   +  S  D     + + KG+     + F      
Sbjct: 32  YNLFYIGKNADLYSCPGEEPKVLLVRSDRCSVFDIPLNLEINGKGVSQTAISNFGADFAK 91

Query: 63  EAGIPTQMER-------LLSDTECLVKKLDMV---------PVECVVRNRAAGSLV---- 102
           +AGI T +          ++    +++    +           E + RN   GSL     
Sbjct: 92  KAGIRTAILSENVDSSLSIAPRCQMMELCKPLEAQIDGEVVQFELIFRNYLTGSLFEATQ 151

Query: 103 ---KRLG------IEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKE 153
                 G      ++E  +   PLF    K   + D  +N            E    +  
Sbjct: 152 KGQDPYGLNLSSDLKEWSKFETPLFTPTTK--GVKDIPLNSQKVR-------ETFPEIVS 202

Query: 154 LTYKANDVLKKLFDDAGLILVDFKLE-FGLYKGEVVLGDEF-SPDGSRL-----WDKETL 206
              K      K   D G+I+VD KLE F   KGE VLGDE  +P+ SR      +D    
Sbjct: 203 SLEKLFKDFTKFAQDNGIIVVDTKLEVFVNSKGEWVLGDEVLTPESSRFISKEDFDAGNY 262

Query: 207 EKMDKDRFRQSLGGLIEAYEAVARRLGVQ 235
             MDK   R    G  E ++  A+ L   
Sbjct: 263 ISMDKQILRDF--GKSENWKEKAKDLKAG 289


>UniRef50_O28996 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
           n=1 Tax=Archaeoglobus fulgidus RepID=PUR7_ARCFU
          Length = 331

 Score =  146 bits (370), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 62/275 (22%), Positives = 99/275 (36%), Gaps = 58/275 (21%)

Query: 10  GKAKTVYST----ENPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEA 64
           G  K +       E P L    F N  S  D G   ++ + KG        +   KL EA
Sbjct: 2   GSVKDLVVLKEPAEKPGLGRFIFSNRYSVFDYGEMPDKIEDKGRALCMVTAYFFEKLEEA 61

Query: 65  GIPTQMERLLSD-------------TECLVKKLDMV-------------------PVECV 92
           GI T    L+                E  VK + ++                   P+E +
Sbjct: 62  GIATHYLGLVEGGKVRRFDEVENAVNEMEVKLVRVIKPKNGDYSIFKTLKGNFLVPLEII 121

Query: 93  VRN-RAAGSLVKR--------------LGIEEGIELNPPLFDLFLKNDAMHDPMVNESYC 137
            RN    GS + R                IE G+ L  P+ D   K + + D  ++ S  
Sbjct: 122 YRNSIPEGSSLLRRIERGEAKPEDFGLTKIEAGMRLERPIVDFSTKLEDV-DRYLSHSEA 180

Query: 138 ETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE-VVLGDEF-SP 195
           +    +S E    +KEL  K ++++ +    AGLI  D K+E  L     +++ D   +P
Sbjct: 181 KEISGLSDEEFEALKELVVKVDEIITREVSKAGLINEDGKIEVALDDERNLMVVDAVGTP 240

Query: 196 DGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVAR 230
           D  R        ++ K+  R+      E Y+ V +
Sbjct: 241 DECRF--SFDGFEVSKELLREYYRK-TEWYDKVRQ 272


>UniRef50_Q3IMR8 Phosphoribosylaminoimidazolesuccinocarboxamide synthase n=3
           Tax=Halobacteriaceae RepID=Q3IMR8_NATPD
          Length = 339

 Score =  145 bits (367), Expect = 9e-34,   Method: Composition-based stats.
 Identities = 41/254 (16%), Positives = 80/254 (31%), Gaps = 57/254 (22%)

Query: 26  LEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLL---------- 74
             F +D S  D G   +    KG            +L   GIPT    ++          
Sbjct: 23  FVFTDDYSVFDWGKMPDSIPNKGASLCAMGAANFERLEAEGIPTHYRGVVSGGEVVALSE 82

Query: 75  ---SDTECLVKKLDM------------------------VPVECVVRN-RAAGSLVKR-- 104
                 E  ++   +                        +P+E V RN    GS ++   
Sbjct: 83  AVSPPREMAIELTQVPDLPHDGREYDYEAFHADAGENYLIPLEIVFRNTVPVGSSLRSRA 142

Query: 105 ----LGIEEGI------ELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKEL 154
                G++         +L  P+ +   K +     +   S         K ++  ++ +
Sbjct: 143 DPEAFGLDYEEWPDEPVDLPEPVVEFSTKFEESDRYL---SRSNADYIAGKADIDDLESV 199

Query: 155 TYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEF-SPDGSRLWDKETLEKMDKDR 213
               N ++ +   +AGL   D K+E   + GE+ + D   + D +R       +++ K+ 
Sbjct: 200 ARDVNTIVTETAAEAGLKHEDGKIECLYFDGEIRVADVVGTFDENRF--SHDGQQLSKEV 257

Query: 214 FRQSLGGLIEAYEA 227
            RQ        +  
Sbjct: 258 VRQYHKRTQSEWVE 271


>UniRef50_B2L3N2 Phosphoribosylaminoimidazole carboxylase n=3 Tax=Bdelloidea
           RepID=B2L3N2_9BILA
          Length = 572

 Score =  139 bits (351), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 48/279 (17%), Positives = 90/279 (32%), Gaps = 76/279 (27%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRND-------------------------------- 31
             +L+ G+ KT+YS  +   L+  FR D                                
Sbjct: 10  GQKLFDGRTKTIYSMIDQPGLICIFRKDFYQPAGSTLSIPGSRRSSIDSSIFFLQQQQQQ 69

Query: 32  TSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEC-LVKKLDMVPVE 90
               +G    +   KG++       +   L EA IPT            + +K  M+P+ 
Sbjct: 70  KQNNNGTTNMEIPGKGVLITSITTCVYEILREASIPTFYVAPHPQPAMFIARKCTMIPIL 129

Query: 91  CVVRNRAAGSLVKRLG-IEEGIELNPPLFDLFLKNDAM---------------------- 127
            +VR  A  + +KR   +  G    PP+ +++ K   +                      
Sbjct: 130 WIVRRLATETYIKRNPSVVNGHRFVPPIVEIYHKRHPLIYRRLTLSSLDENVVSSHESLL 189

Query: 128 ----------------HDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFD-DAG 170
                           +D ++N  +      +++  +  M E      D+L+ ++     
Sbjct: 190 DDDDSDVDECLSSIWSYDQLLNAQFDIEDLKITQTEIEYMYETCCTIFDILEHIWMVKKN 249

Query: 171 LILVDFKLEFGL---YKGEVVLGDEFSPDGSRLWDKETL 206
             L+D KLEFG+      E+VL + F  +   +      
Sbjct: 250 CQLIDLKLEFGITTTTTKEIVLANAFDIEAWHILRATEK 288


>UniRef50_D1JGB5 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
           n=2 Tax=uncultured archaeon RepID=D1JGB5_9ARCH
          Length = 346

 Score =  139 bits (351), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 55/266 (20%), Positives = 92/266 (34%), Gaps = 63/266 (23%)

Query: 10  GKAKTVYST-----ENPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
           G  K +          P      F +  S  D G   +    KG        +   KL E
Sbjct: 2   GSVKDLLVIAQPSKNKPGTAQFVFSDRYSVFDWGEMPDLIQDKGAAICITTAYFFEKLEE 61

Query: 64  AGIPTQMERLLSDTEC----------------LVKKLDM--------------------V 87
            GIPT    L+ + +                 L++ L                      +
Sbjct: 62  MGIPTHYRGLVEEDKIKRLAALNSPQSRMELNLLRVLKPRIIGDTYDYSIYKEERTNILI 121

Query: 88  PVECVVRNRA-----------AGSL-VKRLGIEE----GIELNPPLFDLFLKNDAMHDPM 131
           P+E + RN             AGSL ++ +G+++    G  L  P+ D+  K +A  D  
Sbjct: 122 PLEIIYRNSLPEGSSVFRRLKAGSLSLEDIGLDKMPYPGQVLERPVLDVSTKLEAS-DRY 180

Query: 132 VNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK-GEVVLG 190
           +N +  +    +S+  L  +   T + N+++ +    AGL   D KLEFG  +   + L 
Sbjct: 181 INWNDAKELAGLSEAELEEITSATLRINELITREARMAGLTNEDGKLEFGFDEARNLTLV 240

Query: 191 DEF-SPDGSRLWDKETLEKMDKDRFR 215
           D   + D  R         + K+  R
Sbjct: 241 DTLGTLDECRFTY--DGLPVSKEIAR 264


>UniRef50_Q9HNU7 Putative phosphoribosylaminoimidazole-succinocarboxamide synthase
           n=8 Tax=Halobacteriaceae RepID=PUR7_HALSA
          Length = 347

 Score =  138 bits (348), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 52/273 (19%), Positives = 89/273 (32%), Gaps = 66/273 (24%)

Query: 20  NPDLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAEAGIPTQM-------- 70
           +    V EF +  S  D G   +    KG        +   +LA AG+PT          
Sbjct: 26  DLGRGVFEFSDRYSVFDWGEMPDHVPGKGASLCTMGAYTFEQLAAAGVPTHYQGVRTPDG 85

Query: 71  ------ERLLSDTECLVKKLDM------------------------VPVECVVRN-RAAG 99
                 +   + T+ ++    +                        VP+E V RN    G
Sbjct: 86  ETVRLADAPEAPTQMVIDLTQVPTLPFEDGSYDYDRYHDAGGSNYLVPLEVVFRNAVPVG 145

Query: 100 SLVK------RLGIEEGI------ELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKEN 147
           S ++       +GI+         EL   + +   K +     +   S           +
Sbjct: 146 SSLRTRCAPADVGIDADEWPQGPVELPETIVEFSTKYEEQDRYL---SRSMADEIAGDAD 202

Query: 148 LARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDE-FSPDGSRLWDKETL 206
           +A +  L  + N+ +     DAG +  D KLE     GEV + D   + D +R       
Sbjct: 203 IAELDALARRVNETITDCAADAGFVHDDGKLECVYVDGEVRVADVAGTFDENRFRF--DG 260

Query: 207 EKMDKDRFRQ--------SLGGLIEAYEAVARR 231
            ++ K+  RQ         +G + +A  A   R
Sbjct: 261 REVSKEAVRQFYKRSDPEWVGAVKDAKRAADER 293


>UniRef50_B3G3Y1 Saicars n=1 Tax=Adineta vaga RepID=B3G3Y1_ADIVA
          Length = 531

 Score =  129 bits (326), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 51/264 (19%), Positives = 92/264 (34%), Gaps = 69/264 (26%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGAR------------------------ 39
             +L+ GK KT+YS  +   L+   R D     G+                         
Sbjct: 11  HQKLFDGKTKTIYSIIDQPSLICIHRKDHHDSSGSILSIPGSRRSSVDSTIRLNNQQHNR 70

Query: 40  -IEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEC-LVKKLDMVPVECVVRNRA 97
                  KGM+           L EA IPT      +  +  + KK  M+P+  ++R  A
Sbjct: 71  NHTDILSKGMLTTSITTCAYEILREASIPTFYVAPYNQPDMFIAKKCTMIPILWIIRRLA 130

Query: 98  AGSLVKR-LGIEEGIELNPPLFDLFLK---------------------------NDAMH- 128
             + VKR  GI  G    PP+ ++F K                           +D    
Sbjct: 131 NETCVKRNPGIINGHRFIPPMIEIFYKRHPFLYKQSTIDIGDDNLEYDRESQFDDDESDL 190

Query: 129 DPMVNE---------SYCETFGW-VSKENLARMKELTYKANDVLKKLFD-DAGLILVDFK 177
           D  ++          ++  T    +S +++  M E+     D+L+ ++       L+D K
Sbjct: 191 DECISSIWSYEQLLNTHINTENLKISHKDIEYMYEICCTIFDILEHVWMVKKNCQLIDLK 250

Query: 178 LEFGLY---KGEVVLGDEFSPDGS 198
           +EFG+      E+++ + +  +  
Sbjct: 251 IEFGITTTSPKEIIVSNVYDVETW 274


>UniRef50_B5YAR6 Phosphoribosylaminoimidazole-succinocarboxamide synthase n=2
           Tax=Dictyoglomus RepID=B5YAR6_DICT6
          Length = 338

 Score =  129 bits (324), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 54/281 (19%), Positives = 91/281 (32%), Gaps = 64/281 (22%)

Query: 10  GKAKTVYSTENP-----DLLVLEFRNDTSAGD-GARIEQFDRKGMVNNKFNYFIMSKLAE 63
           G  K +   E P           F +  S  D G   +  D KG        +   KL  
Sbjct: 2   GSVKDLIVIEKPTEKKLGRGRFLFSDRYSVFDYGEMPDLIDDKGKAICIATAYFFEKLEN 61

Query: 64  AGIPTQMERLLSDTEC----------------LVKKLDM--------------------V 87
            GI T    L+ D +                 +V+ L                      +
Sbjct: 62  LGIKTHYIGLVEDDKIKTLYELKEPTNVMEFKMVRVLKPELQENIYNYSIFKKERSNFLI 121

Query: 88  PVECVVRN-RAAGSLV-KRLG--------------IEEGIELNPPLFDLFLKNDAMHDPM 131
           P+E + RN    GS V KRL                E G +L  P+ D   K +  +D  
Sbjct: 122 PLEVIYRNALPEGSSVFKRLKEGSLNLEEIGLDKMPEPGQKLEKPIVDFSTKLEV-NDRY 180

Query: 132 VNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLG 190
           +++        +S+    +++ LT   +D++ +      L   D K+E+ L  +  ++L 
Sbjct: 181 LSKKEALEISGLSETEFEKLRNLTLFIDDLITEETRKINLNNEDGKVEYALDLERNIMLV 240

Query: 191 DEF-SPDGSRLWDKETLEKMDKDRFRQSLGGLIEAYEAVAR 230
           D   + D  R         + K+  R       + Y+ V  
Sbjct: 241 DALGTLDECRF--TFEGIPVSKEIARIYYRK-TDWYKEVEE 278


>UniRef50_Q5IWX2 Plastid phosphoribosylaminoimidazole-succinocarboxamide synthase
           (Fragment) n=1 Tax=Prototheca wickerhamii
           RepID=Q5IWX2_PROWI
          Length = 245

 Score =  126 bits (317), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 31/145 (21%), Positives = 50/145 (34%), Gaps = 23/145 (15%)

Query: 8   YRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIP 67
           Y GK +  Y     D L++   +  SA D         KG + N+ + + M       +P
Sbjct: 106 YVGKVRDTYDL--GDKLLIVTTDRQSAFDRHLAS-IPFKGQILNQTSAWWMEATRSI-VP 161

Query: 68  TQMERLLSDTECLVKKLDMVPVECVVRNRAAGS-----------LVKRL-------GIEE 109
             +  L      L+ K  + PVE V R    GS             +R        G+ +
Sbjct: 162 NALLGLPDPNASLMTKCTVFPVEFVCRGYMTGSTDTSLWTHYAAGERRYCGNDFPDGMVK 221

Query: 110 GIELNPPLFDLFLKNDAMHDPMVNE 134
              L   +     K+ A HD  ++ 
Sbjct: 222 NARLPVNVITPTTKS-AEHDVPISP 245


>UniRef50_B2L3L7 Phosphoribosylaminoimidazole carboxylase n=1 Tax=Philodina roseola
           RepID=B2L3L7_9BILA
          Length = 490

 Score =  124 bits (313), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 45/270 (16%), Positives = 85/270 (31%), Gaps = 75/270 (27%)

Query: 4   QAELYRGKAKTVYSTENPDLLVLEF---------------RNDTSAGD---------GAR 39
             +L+ GK +T+YS  +   L+                   N  ++ D          + 
Sbjct: 12  GQKLFEGKTQTIYSVIDQSNLICIHQRDADDSTEILSTTSSNRRTSFDAGFRGRSRSHSL 71

Query: 40  IEQFDRKGMVNNKFNYFIMSKLAEAGIPTQMERLLSDTEC-LVKKLDMVPVECVVRNRAA 98
            E    +       N  +   L EA IP         ++  + +K  M+P+   +R  A 
Sbjct: 72  AENISTRATWITSINICVYEILREASIPNYFIAPHPQSDMFIAQKCTMIPLIWFIRRVAN 131

Query: 99  GSLVKRL-GIEEGIELNPPLFDLFL-----------------------KNDAMHDPMVNE 134
            + VK+   +  G    PP+ +L                         + + + D   ++
Sbjct: 132 ENYVKQHSNVPLGQRFVPPIVELCSQRRPIVYRRLTLSNLEETILNSDRTNVIDDENDDD 191

Query: 135 SYCETFGW------------------------VSKENLARMKELTYKANDVLKKLF-DDA 169
              +                            +S  +L  M E+     D+L+ ++    
Sbjct: 192 VEKKQLNDDDSSISIFSSDQLAHLPFDISSMKISTNDLELMYEICLTLFDILEHVWMTTK 251

Query: 170 GLILVDFKLEFGL-YKGEVVLGDEFSPDGS 198
              L+D KLEFGL    ++V+   F  D  
Sbjct: 252 KYQLIDLKLEFGLTTTKDIVVAHVFDVDSW 281


>UniRef50_Q2GR92 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2GR92_CHAGB
          Length = 220

 Score =  117 bits (295), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 27/151 (17%), Positives = 53/151 (35%), Gaps = 9/151 (5%)

Query: 32  TSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEA--GIPTQMERLLSDTECLVKKLDMVPV 89
            SA D         KG +    +      L+    G+      L       + + +   +
Sbjct: 21  VSAYDVILKNGIPTKGAILTLLSAKWFEVLSSRVPGLKHHFLHLGPPPASGLSQEEQQML 80

Query: 90  E---CVVRNRAAGS---LVKRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWV 143
                 VR +   +   L +  G++    L  P++    K + + D  +N S  E  G V
Sbjct: 81  RGRSMTVRYKETQTIHGLPQPAGLKRCERLPKPIYTPSTKAE-LGDKDINISPDEARGIV 139

Query: 144 SKENLARMKELTYKANDVLKKLFDDAGLILV 174
             +   R++EL     +      ++ G+I+V
Sbjct: 140 GDKYAGRLEELALACYNAGAAYAEERGIIIV 170


>UniRef50_Q67KF5 Putative uncharacterized protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KF5_SYMTH
          Length = 179

 Score =  114 bits (285), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 40/207 (19%), Positives = 71/207 (34%), Gaps = 40/207 (19%)

Query: 3   KQAELYRGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLA 62
           K+  L+ G    V++T+  D L+LEF +                          I   L 
Sbjct: 7   KRERLWAGDGLAVHATDRADRLILEFED-----------------ETVCAAALRIQEILV 49

Query: 63  EAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIELNPPLFDLFL 122
             G+ T      +    L++K+  +PVE       AG    RL   +G            
Sbjct: 50  GHGLATSFAARFTSRSFLIRKVQPLPVEVAAE---AGPGEVRLAFRDG------------ 94

Query: 123 KNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGL 182
                 D  ++    E    ++ E L R+++    A   L+      G+  +  ++ FGL
Sbjct: 95  ------DRELSREEAEAA--LTPERLERIEDAALHAARTLRAHLSLRGVERLQLRMRFGL 146

Query: 183 YKGEVVLGDEFSPDGSRLWDKETLEKM 209
            +    L    +P   RL  ++  E +
Sbjct: 147 TEEGACLMQVMNPLECRLGSEDMKEVL 173


>UniRef50_UPI00015FF598 UPI00015FF598 related cluster n=1 Tax=Drosophila melanogaster
           RepID=UPI00015FF598
          Length = 183

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 1/100 (1%)

Query: 2   QKQAELYRGKAKTVYSTEN-PDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSK 60
           +    +  GK K VY     P L +L  ++  +AGDG +      K  ++N  N  ++  
Sbjct: 6   KLGKVIIEGKTKQVYDLPEQPGLCLLLSKDRITAGDGVKAHDLAGKAEISNTTNGQVVRL 65

Query: 61  LAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGS 100
           L EAGI T   +       + +K  M+P+E V R  A GS
Sbjct: 66  LNEAGIRTAYVKQCGAKSFIARKCQMIPIEWVTRRLATGS 105


>UniRef50_D0NC79 Phosphoribosylaminoimidazole-succinocarboxamide synthase, putative
           n=1 Tax=Phytophthora infestans T30-4 RepID=D0NC79_PHYIN
          Length = 143

 Score =  110 bits (275), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 24/104 (23%), Positives = 38/104 (36%), Gaps = 4/104 (3%)

Query: 9   RGKAKTVYSTENPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYFIMSKLAEAGIPT 68
            GK + VY  E  D ++L   +  SA D A       K  V    + +  ++     +  
Sbjct: 44  TGKVRDVYVFE--DRVLLVSTDRQSAFDRALAS-VPFKSRVLTLTSVWWFNQTKHI-VAN 99

Query: 69  QMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRLGIEEGIE 112
            +  +   +  L KK  + PVE VVR    GS    +       
Sbjct: 100 HLLGVPHPSAMLCKKCTVFPVEFVVRGYITGSTSTSMWTNYKKR 143


>UniRef50_UPI0001746899 phosphoribosylaminoimidazolesuccinocarboxamide synthase n=1
           Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI0001746899
          Length = 440

 Score = 92.2 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 32/167 (19%), Positives = 61/167 (36%), Gaps = 28/167 (16%)

Query: 86  MVPVECVVRNRAAG--SLVKRLG-------------------IEEGIELNPPLFDLFLKN 124
           ++P+E +VR    G  S++++                     ++    L  P+FDL  K+
Sbjct: 180 VIPLEYIVRFGITGGSSVLRKYASLSDADKKTYENELGLSQAMQAWQFLPRPIFDLTSKH 239

Query: 125 DAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYK 184
           +   D  V +        +  +      +L+      +++L D+ GL+L D K EF + +
Sbjct: 240 EPE-DRNVTKQEAALMSGMEADAFVSTIKLSLLGAWAVRQLLDEIGLLLWDIKWEFAVDE 298

Query: 185 GEVVLGDEFSPDGSR---LWDKETLE---KMDKDRFRQSLGGLIEAY 225
           GE    D    D  R     + E  +     +K   R         +
Sbjct: 299 GEFFFVDTIDTDSFRATAFLETEGKKIVLHYNKQSMRDYYKIAEATW 345


>UniRef50_Q3CXY3 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Streptococcus agalactiae H36B RepID=Q3CXY3_STRAG
          Length = 92

 Score = 84.9 bits (209), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 26/74 (35%), Positives = 44/74 (59%)

Query: 103 KRLGIEEGIELNPPLFDLFLKNDAMHDPMVNESYCETFGWVSKENLARMKELTYKANDVL 162
           KR G+E G  L  P+ + + KND ++DP +N+ + +  G V+ E +A +K  T + N++L
Sbjct: 2   KRFGVEVGRVLETPIVEFYYKNDDLNDPFINDEHVKFLGIVNDEEIAYLKGETRRINELL 61

Query: 163 KKLFDDAGLILVDF 176
           K  F   G+  +DF
Sbjct: 62  KDWFAQIGITWIDF 75


>UniRef50_B4N726 GK23628 n=2 Tax=Drosophila willistoni RepID=B4N726_DROWI
          Length = 233

 Score = 74.8 bits (183), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 20/86 (23%), Positives = 32/86 (37%), Gaps = 9/86 (10%)

Query: 156 YKANDVLKKLFDDAGLILVDFKLEFGLY-KGEVVLGDEFSPDGSRLWDKETLEKM-DKDR 213
                VL + +      L+D K+E G+   G +VL D       RLW       M DK  
Sbjct: 1   MSCYMVLDRAWQIENCALIDMKVENGIDTDGNIVLADIIDSVSWRLWPPGDKRLMVDKQL 60

Query: 214 FRQ-------SLGGLIEAYEAVARRL 232
           +R         +  +   +  V+ +L
Sbjct: 61  YRNLTSVTSSDMDTVKRNFIWVSEQL 86


>UniRef50_Q9F8W0 SAICAR synthetase (Fragment) n=2 Tax=Rhizobium/Agrobacterium group
           RepID=Q9F8W0_RHIRD
          Length = 114

 Score = 59.0 bits (142), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 18/66 (27%), Positives = 30/66 (45%), Gaps = 12/66 (18%)

Query: 179 EFGLYK-GEVVLGDEF-SPDGSRLWDKETLE----------KMDKDRFRQSLGGLIEAYE 226
           EFG  + G ++L DE  +PD SR W  ++ +            DKD  R  +G   + Y+
Sbjct: 1   EFGTDENGTIILADEIHTPDSSRYWMADSYDESFREGKRPASFDKDFVRAWVGERCDPYK 60

Query: 227 AVARRL 232
               ++
Sbjct: 61  DAVPKI 66


>UniRef50_Q0PQG5 Phosphoribosylaminoimidazole-succinocarboxamide synthase (Fragment)
           n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2'
           RepID=Q0PQG5_9GAMM
          Length = 184

 Score = 54.8 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 9/39 (23%), Positives = 17/39 (43%)

Query: 148 LARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGE 186
             ++++L+        +     G+I+ D K EFGL    
Sbjct: 140 AEQVRDLSLHIYTEAAEYARSKGIIIADTKFEFGLDDNR 178


>UniRef50_Q5B800 Predicted protein n=3 Tax=Leotiomyceta RepID=Q5B800_EMENI
          Length = 852

 Score = 53.7 bits (128), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 37/286 (12%), Positives = 79/286 (27%), Gaps = 54/286 (18%)

Query: 3   KQAELYRGKAKTVYSTENP------DLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNYF 56
           +   +  G++K +Y  E P      + +++  +    +       +    G +    +  
Sbjct: 237 RLRLVVEGESKQIYKVETPLTRHFDNRILVFLKPTIYSHSKQATAEIAGLGAIRAAGSRL 296

Query: 57  IMSKLAEAGIPTQMERLLSDTECLVKKLDMVPVECVVRNRAAGSLVKRL---------GI 107
            +  L  AGI    + L        +  ++  +E V +   AG+               +
Sbjct: 297 FLEMLHRAGISHTYDGLNVHGLIWARSTEITQIETVYKGLCAGTDRHSFFGMVTDPKVTL 356

Query: 108 EEGIELNPPLFDL-------FLKN------------------DAMHD-------PMVNES 135
             G     P             K                   D  +D         + + 
Sbjct: 357 PTGQYKRGPYVRFDWRNPNHTYKGINPATHPFYHLMEASVGKDVFYDNYLTGRAKPLGDK 416

Query: 136 YCETFGWVSKENLARMKELTYKANDVLKKLFDDAGLILVDFKLEFGLYKGEVVLGDEFSP 195
                     +++    + T +    ++      GL + D  +   L      +  E + 
Sbjct: 417 CVPEELVHGVQDVEASVDWTMRIFFTIQYYLHQIGLEVQDGCV--MLDPTGRTMWSEINQ 474

Query: 196 DGSRL-W----DKETLEKMDKDRFRQSLGGLIEAYEAVARRLGVQL 236
           D  R+ W    +    +  DKD +R       EA      +L   L
Sbjct: 475 DCMRIKWREVTNANGQDAFDKDVWRAGGSSAEEAILDKWTQLNSLL 520


>UniRef50_Q46F31 Putative uncharacterized protein n=1 Tax=Methanosarcina barkeri
          str. Fusaro RepID=Q46F31_METBF
          Length = 47

 Score = 40.2 bits (93), Expect = 0.066,   Method: Composition-based stats.
 Identities = 16/27 (59%), Positives = 22/27 (81%)

Query: 4  QAELYRGKAKTVYSTENPDLLVLEFRN 30
          + +LY GKAKT+Y T++PD L+ EFRN
Sbjct: 3  REQLYSGKAKTIYKTDDPDTLITEFRN 29


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.311    0.160    0.455 

Lambda     K      H
   0.267   0.0493    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,638,427,345
Number of Sequences: 3077464
Number of extensions: 76351669
Number of successful extensions: 190313
Number of sequences better than 1.0e-01: 137
Number of HSP's better than  0.1 without gapping: 320
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 188841
Number of HSP's gapped (non-prelim): 414
length of query: 237
length of database: 1,040,396,356
effective HSP length: 125
effective length of query: 112
effective length of database: 655,713,356
effective search space: 73439895872
effective search space used: 73439895872
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 92 (39.8 bits)
