Phyre 2 Results for P0ACV6

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Email | l.a.kelley@imperial.ac.uk
Description | P0ACV6
Date | Thu Jan 5 11:19:10 GMT 2012
Unique Job ID | 5f77e12444d7f585

Summary |

Top model
Image coloured by rainbow N → C terminus
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Model (left) based on template c3dgvB_
Top template information
PDB header:hydrolase Chain: B: PDB Molecule:carboxypeptidase b2; PDBTitle: crystal structure of thrombin activatable fibrinolysis inhibitor2 (tafi)
Confidence and coverage
Confidence: | 100.0% | Coverage: | 87%
210 residues ( 87% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | T | V | T | R | P | R | A | E | R | G | A | F | P | P | G | T | E | H | Y | G | R | S | L | L | G | A | P | L | I | W | F | P | A | P | A | A | S | R | E | S | G | L | I | L | A | G | T | H | G | D | E | N | S | S | V | V | T | L | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? |  |  |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | C | A | L | R | T | L | T | P | S | L | R | R | H | H | V | V | L | C | V | N | P | D | G | C | Q | L | G | L | R | A | N | A | N | G | V | D | L | N | R | N | F | P | A | A | N | W | K | E | G | E | T | V | Y | R | W | N | S | A | A | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  | ? |  |  |  |  | ? |  | ? | ? |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | E | R | D | V | V | L | L | T | G | D | K | P | G | S | E | P | E | T | Q | A | L | C | Q | L | I | H | R | I | Q | P | A | W | V | V | S | F | H | D | P | L | A | C | I | E | D | P | R | H | S | E | L | G | E | W | L | A | Q | A | F | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | L | P | L | V | T | S | V | G | Y | E | T | P | G | S | F | G | S | W | C | A | D | L | N | L | H | C | I | T | A | E | F | P | P | I | S | S | D | E | A | S | E | K | Y | L | F | A | M | A | N | L | L | R | W | H | P | K | D | A | I | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | .
Sequence |  | P | S
Secondary structure |  |  |
SS confidence |  |  |
Disorder |  | ? | ?
Disorder confidence |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c3dgvB_ |

### PDB 3dgv chain B

Region: 17 - 233
Aligned: 210
Modelled: 217
Confidence: 100.0%
Identity: 26%
PDB header:hydrolase
Chain: B: PDB Molecule:carboxypeptidase b2;
PDBTitle: crystal structure of thrombin activatable fibrinolysis inhibitor2 (tafi)

Phyre2
2 |
| c2nsmA_ |

### PDB 2nsm chain A

Region: 17 - 229
Aligned: 209
Modelled: 210
Confidence: 100.0%
Identity: 26%
PDB header:hydrolase
Chain: A: PDB Molecule:carboxypeptidase n catalytic chain;
PDBTitle: crystal structure of the human carboxypeptidase n (kininase i)2 catalytic domain

Phyre2
3 |
| c1ayeA_ |

### PDB 1aye chain A

Region: 17 - 233
Aligned: 209
Modelled: 217
Confidence: 100.0%
Identity: 18%
PDB header:serine protease
Chain: A: PDB Molecule:procarboxypeptidase a2;
PDBTitle: human procarboxypeptidase a2

Phyre2
4 |
| c2boaB_ |

### PDB 2boa chain B

Region: 17 - 233
Aligned: 209
Modelled: 217
Confidence: 100.0%
Identity: 20%
PDB header:hydrolase
Chain: B: PDB Molecule:carboxypeptidase a4;
PDBTitle: human procarboxypeptidase a4.

Phyre2
5 |
| c1nsaA_ |

### PDB 1nsa chain A

Region: 17 - 233
Aligned: 209
Modelled: 217
Confidence: 100.0%
Identity: 21%
PDB header:serine protease
Chain: A: PDB Molecule:procarboxypeptidase b;
PDBTitle: three-dimensional structure of porcine procarboxypeptidase2 b: a structural basis of its inactivity

Phyre2
6 |
| c1jqgA_ |

### PDB 1jqg chain A

Region: 17 - 232
Aligned: 207
Modelled: 215
Confidence: 100.0%
Identity: 23%
PDB header:hydrolase
Chain: A: PDB Molecule:carboxypeptidase a;
PDBTitle: crystal structure of the carboxypeptidase a from2 helicoverpa armigera

Phyre2
7 |
| c1uwyA_ |

### PDB 1uwy chain A

Region: 17 - 229
Aligned: 190
Modelled: 191
Confidence: 100.0%
Identity: 27%
PDB header:hydrolase
Chain: A: PDB Molecule:carboxypeptidase m;
PDBTitle: crystal structure of human carboxypeptidase m

Phyre2
8 |
| c1h8lA_ |

### PDB 1h8l chain A

Region: 17 - 229
Aligned: 190
Modelled: 191
Confidence: 100.0%
Identity: 23%
PDB header:carboxypeptidase
Chain: A: PDB Molecule:carboxypeptidase gp180 residues 503-882;
PDBTitle: duck carboxypeptidase d domain ii in complex with gemsa

Phyre2
9 |
| c3mn8A_ |

### PDB 3mn8 chain A

Region: 17 - 229
Aligned: 188
Modelled: 189
Confidence: 100.0%
Identity: 29%
PDB header:hydrolase
Chain: A: PDB Molecule:lp15968p;
PDBTitle: structure of drosophila melanogaster carboxypeptidase d isoform 1b2 short

Phyre2
10 |
| d1ayea1 |

### PDB 1aye chain A domain 1

Region: 17 - 235
Aligned: 211
Modelled: 219
Confidence: 100.0%
Identity: 21%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
11 |
| d1nsaa1 |

### PDB 1nsa chain A domain 1

Region: 17 - 232
Aligned: 208
Modelled: 216
Confidence: 100.0%
Identity: 18%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
12 |
| d1uwya2 |

### PDB 1uwy chain A domain 2

Region: 17 - 233
Aligned: 194
Modelled: 195
Confidence: 100.0%
Identity: 26%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
13 |
| d1obra_ |

### PDB 1obr chain A

Region: 17 - 233
Aligned: 210
Modelled: 217
Confidence: 100.0%
Identity: 23%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Carboxypeptidase T

Phyre2
14 |
| d1kwma1 |

### PDB 1kwm chain A domain 1

Region: 17 - 231
Aligned: 207
Modelled: 215
Confidence: 100.0%
Identity: 19%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
15 |
| d1jqga1 |

### PDB 1jqg chain A domain 1

Region: 17 - 232
Aligned: 207
Modelled: 215
Confidence: 100.0%
Identity: 24%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
16 |
| d1z5ra1 |

### PDB 1z5r chain A domain 1

Region: 17 - 231
Aligned: 207
Modelled: 207
Confidence: 100.0%
Identity: 19%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
17 |
| d1m4la_ |

### PDB 1m4l chain A

Region: 17 - 233
Aligned: 209
Modelled: 217
Confidence: 100.0%
Identity: 20%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
18 |
| d2bo9a1 |

### PDB 2bo9 chain A domain 1

Region: 17 - 232
Aligned: 208
Modelled: 216
Confidence: 100.0%
Identity: 20%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
19 |
| c3d4uA_ |

### PDB 3d4u chain A

Region: 17 - 231
Aligned: 206
Modelled: 213
Confidence: 100.0%
Identity: 25%
PDB header:hydrolase/hydrolase inhibitor
Chain: A: PDB Molecule:carboxypeptidase b2;
PDBTitle: bovine thrombin-activatable fibrinolysis inhibitor (tafia) in complex2 with tick-derived carboxypeptidase inhibitor.

Phyre2
20 |
| d2c1ca1 |

### PDB 2c1c chain A domain 1

Region: 17 - 232
Aligned: 208
Modelled: 216
Confidence: 100.0%
Identity: 23%
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Family: Pancreatic carboxypeptidases

Phyre2
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |
37 |
38 |
| c1cpbA_ |

### PDB 1cpb chain A

Region: 5 - 65
Aligned: 61
Modelled: 61
Confidence: 99.1%
Identity: 16%
PDB header:hydrolase (c-terminal peptidase)
Chain: A: PDB Molecule:carboxypeptidase b;
PDBTitle: structure of carboxypeptidase b at 2.8 angstroms resolution

Phyre2
39 |
40 |
41 |
42 |
43 |
44 |
45 |
46 |
47 |
48 |
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50 |
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53 |
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76 |
77 |
78 |
79 |
80 |
81 |
82 |
83 |

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c3dgvB_ |
|  | 100.0 | 26 | PDB header:hydrolase Chain: B: PDB Molecule:carboxypeptidase b2; PDBTitle: crystal structure of thrombin activatable fibrinolysis inhibitor2 (tafi)
2 | c2nsmA_ |
|  | 100.0 | 26 | PDB header:hydrolase Chain: A: PDB Molecule:carboxypeptidase n catalytic chain; PDBTitle: crystal structure of the human carboxypeptidase n (kininase i)2 catalytic domain
3 | c1ayeA_ |
|  | 100.0 | 18 | PDB header:serine protease Chain: A: PDB Molecule:procarboxypeptidase a2; PDBTitle: human procarboxypeptidase a2
4 | c2boaB_ |
|  | 100.0 | 20 | PDB header:hydrolase Chain: B: PDB Molecule:carboxypeptidase a4; PDBTitle: human procarboxypeptidase a4.
5 | c1nsaA_ |
|  | 100.0 | 21 | PDB header:serine protease Chain: A: PDB Molecule:procarboxypeptidase b; PDBTitle: three-dimensional structure of porcine procarboxypeptidase2 b: a structural basis of its inactivity
6 | c1jqgA_ |
|  | 100.0 | 23 | PDB header:hydrolase Chain: A: PDB Molecule:carboxypeptidase a; PDBTitle: crystal structure of the carboxypeptidase a from2 helicoverpa armigera
7 | c1uwyA_ |
|  | 100.0 | 27 | PDB header:hydrolase Chain: A: PDB Molecule:carboxypeptidase m; PDBTitle: crystal structure of human carboxypeptidase m
8 | c1h8lA_ |
|  | 100.0 | 23 | PDB header:carboxypeptidase Chain: A: PDB Molecule:carboxypeptidase gp180 residues 503-882; PDBTitle: duck carboxypeptidase d domain ii in complex with gemsa
9 | c3mn8A_ |
|  | 100.0 | 29 | PDB header:hydrolase Chain: A: PDB Molecule:lp15968p; PDBTitle: structure of drosophila melanogaster carboxypeptidase d isoform 1b2 short
10 | d1ayea1 |
|  | 100.0 | 21 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
11 | d1nsaa1 |
|  | 100.0 | 18 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
12 | d1uwya2 |
|  | 100.0 | 26 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
13 | d1obra_ |
|  | 100.0 | 23 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Carboxypeptidase T
14 | d1kwma1 |
|  | 100.0 | 19 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
15 | d1jqga1 |
|  | 100.0 | 24 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
16 | d1z5ra1 |
|  | 100.0 | 19 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
17 | d1m4la_ |
|  | 100.0 | 20 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
18 | d2bo9a1 |
|  | 100.0 | 20 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
19 | c3d4uA_ |
|  | 100.0 | 25 | PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:carboxypeptidase b2; PDBTitle: bovine thrombin-activatable fibrinolysis inhibitor (tafia) in complex2 with tick-derived carboxypeptidase inhibitor.
20 | d2c1ca1 |
|  | 100.0 | 23 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
21 | d1h8la2 |
| not modelled | 100.0 | 24 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:Pancreatic carboxypeptidases
22 | c3k2kA_ |
| not modelled | 100.0 | 23 | PDB header:hydrolase Chain: A: PDB Molecule:putative carboxypeptidase; PDBTitle: crystal structure of putative carboxypeptidase (yp_103406.1) from2 burkholderia mallei atcc 23344 at 2.49 a resolution
23 | c3l2nA_ |
| not modelled | 100.0 | 23 | PDB header:hydrolase Chain: A: PDB Molecule:peptidase m14, carboxypeptidase a; PDBTitle: crystal structure of putative carboxypeptidase a (yp_562911.1) from2 shewanella denitrificans os-217 at 2.39 a resolution
24 | c1cpbB_ |
| not modelled | 100.0 | 18 | PDB header:hydrolase (c-terminal peptidase) Chain: B: PDB Molecule:carboxypeptidase b; PDBTitle: structure of carboxypeptidase b at 2.8 angstroms resolution
25 | c3cdxB_ |
| not modelled | 100.0 | 23 | PDB header:hydrolase Chain: B: PDB Molecule:succinylglutamatedesuccinylase/aspartoacylase; PDBTitle: crystal structure of2 succinylglutamatedesuccinylase/aspartoacylase from3 rhodobacter sphaeroides
26 | c3b2yB_ |
| not modelled | 99.9 | 24 | PDB header:hydrolase Chain: B: PDB Molecule:metallopeptidase containing co-catalytic metalloactive PDBTitle: crystal structure of a putative metallopeptidase (sden_2526) from2 shewanella denitrificans os217 at 1.74 a resolution
27 | c3na6A_ |
| not modelled | 99.9 | 21 | PDB header:hydrolase Chain: A: PDB Molecule:succinylglutamate desuccinylase/aspartoacylase; PDBTitle: crystal structure of a succinylglutamate desuccinylase (tm1040_2694)2 from silicibacter sp. tm1040 at 2.00 a resolution
28 | c2qvpC_ |
| not modelled | 99.9 | 23 | PDB header:hydrolase Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative metallopeptidase (sama_0725) from2 shewanella amazonensis sb2b at 2.00 a resolution
29 | c3fmcC_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: C: PDB Molecule:putative succinylglutamate desuccinylase / aspartoacylase; PDBTitle: crystal structure of a putative succinylglutamate desuccinylase /2 aspartoacylase family protein (sama_0604) from shewanella amazonensis3 sb2b at 1.80 a resolution
30 | c2qj8B_ |
| not modelled | 99.9 | 22 | PDB header:hydrolase Chain: B: PDB Molecule:mlr6093 protein; PDBTitle: crystal structure of an aspartoacylase family protein (mlr6093) from2 mesorhizobium loti maff303099 at 2.00 a resolution
31 | d1yw4a1 |
| not modelled | 99.8 | 21 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:AstE/AspA-like
32 | d2gu2a1 |
| not modelled | 99.8 | 17 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:AstE/AspA-like
33 | d2i3ca1 |
| not modelled | 99.8 | 18 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:AstE/AspA-like
34 | c3nh8A_ |
| not modelled | 99.8 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:aspartoacylase-2; PDBTitle: crystal structure of murine aminoacylase 3 in complex with n-acetyl-s-2 1,2-dichlorovinyl-l-cysteine
35 | d1yw6a1 |
| not modelled | 99.8 | 25 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:AstE/AspA-like
36 | d2g9da1 |
| not modelled | 99.8 | 18 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:AstE/AspA-like
37 | d2bcoa1 |
| not modelled | 99.7 | 16 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:AstE/AspA-like
38 | c1cpbA_ |
|  | 99.1 | 16 | PDB header:hydrolase (c-terminal peptidase) Chain: A: PDB Molecule:carboxypeptidase b; PDBTitle: structure of carboxypeptidase b at 2.8 angstroms resolution
39 | d2odfa1 |
| not modelled | 93.2 | 18 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:FGase-like
40 | c1xovA_ |
| not modelled | 86.1 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:ply protein; PDBTitle: the crystal structure of the listeria monocytogenes bacteriophage psa2 endolysin plypsa
41 | d1jwqa_ |
| not modelled | 82.2 | 10 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:N-acetylmuramoyl-L-alanine amidase-like
42 | d1xova2 |
| not modelled | 82.0 | 14 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:N-acetylmuramoyl-L-alanine amidase-like
43 | d2q7sa1 |
| not modelled | 80.5 | 13 | Fold:Phosphorylase/hydrolase-like Superfamily:Zn-dependent exopeptidases Family:FGase-like
44 | c3czxA_ |
| not modelled | 78.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:putative n-acetylmuramoyl-l-alanine amidase; PDBTitle: the crystal structure of the putative n-acetylmuramoyl-l-2 alanine amidase from neisseria meningitidis
45 | c1jd7A_ |
| not modelled | 76.5 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:alpha-amylase; PDBTitle: crystal structure analysis of the mutant k300r of2 pseudoalteromonas haloplanctis alpha-amylase
46 | c3qayC_ |
| not modelled | 69.1 | 6 | PDB header:lyase Chain: C: PDB Molecule:endolysin; PDBTitle: catalytic domain of cd27l endolysin targeting clostridia difficile
47 | c1jaeA_ |
| not modelled | 50.2 | 17 | PDB header:glycosidase Chain: A: PDB Molecule:alpha-amylase; PDBTitle: structure of tenebrio molitor larval alpha-amylase
48 | c1bdeA_ |
| not modelled | 36.0 | 26 | PDB header:aids Chain: A: PDB Molecule:vpr protein; PDBTitle: helical structure of polypeptides from the c-terminal half2 of hiv-1 vpr, nmr, 20 structures
49 | d1g94a2 |
| not modelled | 34.3 | 17 | Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain
50 | c1dsjA_ |
| not modelled | 31.0 | 28 | PDB header:viral peptide Chain: A: PDB Molecule:vpr protein; PDBTitle: nmr solution structure of vpr50_75, 20 structures
51 | c3gaaB_ |
| not modelled | 30.9 | 10 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein ta1441; PDBTitle: the crystal structure of the protein with unknown function from2 thermoplasma acidophilum
52 | d1jaea2 |
| not modelled | 23.0 | 17 | Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain
53 | d1g5ba_ |
| not modelled | 19.4 | 15 | Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:Protein serine/threonine phosphatase
54 | c2wamB_ |
| not modelled | 17.3 | 13 | PDB header:unknown function Chain: B: PDB Molecule:conserved hypothetical alanine and leucine rich PDBTitle: crystal structure of mycobacterium tuberculosis unknown2 function protein rv2714
55 | d1mtza_ |
| not modelled | 17.0 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Proline iminopeptidase-like
56 | c3ne8A_ |
| not modelled | 14.7 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:n-acetylmuramoyl-l-alanine amidase; PDBTitle: the crystal structure of a domain from n-acetylmuramoyl-l-alanine2 amidase of bartonella henselae str. houston-1
57 | c2xt0A_ |
| not modelled | 14.3 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:haloalkane dehalogenase; PDBTitle: dehalogenase dppa from plesiocystis pacifica sir-i
58 | c3mnfA_ |
| not modelled | 14.0 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pac2 family protein; PDBTitle: crystal structure of pac2 family protein from streptomyces avermitilis2 ma
59 | d2p90a1 |
| not modelled | 13.0 | 11 | Fold:Phosphorylase/hydrolase-like Superfamily:Cgl1923-like Family:Cgl1923-like
60 | c3blpX_ |
| not modelled | 11.6 | 19 | PDB header:hydrolase Chain: X: PDB Molecule:alpha-amylase 1; PDBTitle: role of aromatic residues in human salivary alpha-amylase
61 | d1b6ga_ |
| not modelled | 11.4 | 14 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Haloalkane dehalogenase
62 | c1tjnA_ |
| not modelled | 10.5 | 33 | PDB header:lyase Chain: A: PDB Molecule:sirohydrochlorin cobaltochelatase; PDBTitle: crystal structure of hypothetical protein af0721 from archaeoglobus2 fulgidus
63 | d1tjna_ |
| not modelled | 10.5 | 33 | Fold:Chelatase-like Superfamily:Chelatase Family:CbiX-like
64 | d1v6ta_ |
| not modelled | 9.5 | 22 | Fold:7-stranded beta/alpha barrel Superfamily:Glycoside hydrolase/deacetylase Family:LamB/YcsF-like
65 | d2b3ya2 |
| not modelled | 8.4 | 16 | Fold:Aconitase iron-sulfur domain Superfamily:Aconitase iron-sulfur domain Family:Aconitase iron-sulfur domain
66 | c3dddA_ |
| not modelled | 8.4 | 13 | PDB header:transferase Chain: A: PDB Molecule:putative acetyltransferase; PDBTitle: crystal structure of a putative acetyltransferase (np_142035.1) from2 pyrococcus horikoshii at 2.25 a resolution
67 | c2xnsC_ |
| not modelled | 8.3 | 31 | PDB header:hydrolase/peptide Chain: C: PDB Molecule:regulator of g-protein signaling 14; PDBTitle: crystal structure of human g alpha i1 bound to a designed helical2 peptide derived from the goloco motif of rgs14
68 | d1uf3a_ |
| not modelled | 8.2 | 12 | Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:TT1561-like
69 | c1m8lA_ |
| not modelled | 7.8 | 32 | PDB header:viral protein Chain: A: PDB Molecule:vpr protein; PDBTitle: nmr structure of the hiv-1 regulatory protein vpr
70 | d3ck2a1 |
| not modelled | 7.5 | 9 | Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:YfcE-like
71 | c3d3kD_ |
| not modelled | 7.1 | 13 | PDB header:protein binding Chain: D: PDB Molecule:enhancer of mrna-decapping protein 3; PDBTitle: crystal structure of human edc3p
72 | d1e6ua_ |
| not modelled | 6.8 | 22 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases
73 | c2e2xA_ |
| not modelled | 6.6 | 29 | PDB header:signaling protein Chain: A: PDB Molecule:neurofibromin; PDBTitle: sec14 homology module of neurofibromin in complex with2 phosphatitylethanolamine
74 | c3qfnA_ |
| not modelled | 6.4 | 19 | PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of streptococcal asymmetric ap4a hydrolase and2 phosphodiesterase spr1479/saph in complex with inorganic phosphate
75 | d1z6za1 |
| not modelled | 6.1 | 11 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases
76 | c1n7gB_ |
| not modelled | 6.1 | 26 | PDB header:lyase Chain: B: PDB Molecule:gdp-d-mannose-4,6-dehydratase; PDBTitle: crystal structure of the gdp-mannose 4,6-dehydratase2 ternary complex with nadph and gdp-rhamnose.
77 | c3e35A_ |
| not modelled | 6.1 | 19 | PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein sco1997; PDBTitle: actinobacteria-specific protein of unknown function, sco1997
78 | c1zoiC_ |
| not modelled | 5.8 | 9 | PDB header:hydrolase Chain: C: PDB Molecule:esterase; PDBTitle: crystal structure of a stereoselective esterase from2 pseudomonas putida ifo12996
79 | c2x0dA_ |
| not modelled | 5.8 | 6 | PDB header:transferase Chain: A: PDB Molecule:wsaf; PDBTitle: apo structure of wsaf
80 | c2p90B_ |
| not modelled | 5.6 | 11 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein cgl1923; PDBTitle: the crystal structure of a protein of unknown function from2 corynebacterium glutamicum atcc 13032
81 | d1n7ha_ |
| not modelled | 5.6 | 21 | Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Tyrosine-dependent oxidoreductases
82 | c2qjcA_ |
| not modelled | 5.6 | 20 | PDB header:hydrolase Chain: A: PDB Molecule:diadenosine tetraphosphatase, putative; PDBTitle: crystal structure of a putative diadenosine tetraphosphatase
83 | c2ockA_ |
| not modelled | 5.3 | 12 | PDB header:hydrolase Chain: A: PDB Molecule:valacyclovir hydrolase; PDBTitle: crystal structure of valacyclovir hydrolase d123n mutant

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0