BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (203 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac... 270 2e-71 UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac... 228 1e-58 UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact... 226 2e-58 UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos... 212 7e-54 UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba... 211 2e-53 UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ... 202 6e-51 UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter... 199 5e-50 UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 197 2e-49 UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p... 197 2e-49 UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy... 195 8e-49 UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero... 190 2e-47 UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 188 9e-47 UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ... 187 2e-46 UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman... 181 9e-45 UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His... 176 3e-43 UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos... 175 7e-43 UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri... 175 1e-42 UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana... 172 7e-42 UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul... 169 4e-41 UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor... 168 9e-41 UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero... 167 2e-40 UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm... 163 3e-39 UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm... 161 2e-38 UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri... 160 3e-38 UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His... 160 3e-38 UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr... 159 7e-38 UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific... 153 4e-36 UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob... 152 6e-36 UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy... 152 6e-36 UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy... 151 1e-35 UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu... 149 4e-35 UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte... 149 8e-35 UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 148 1e-34 UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI... 147 2e-34 UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5 147 2e-34 UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 147 3e-34 UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra... 146 4e-34 UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell... 145 1e-33 UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy... 142 5e-33 UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI... 141 1e-32 UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 138 9e-32 UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy... 137 2e-31 UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon... 136 4e-31 UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper... 136 4e-31 UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu... 135 9e-31 UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep... 133 3e-30 UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote... 133 4e-30 UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI... 133 4e-30 UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 133 5e-30 UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ... 132 5e-30 UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl... 131 1e-29 UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl... 131 2e-29 UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi... 130 3e-29 UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 130 4e-29 UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 125 1e-27 UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell... 120 3e-26 UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A... 119 4e-26 UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter... 113 3e-24 UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI... 112 6e-24 UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero... 112 7e-24 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 112 1e-23 UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul... 108 1e-22 UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar... 107 3e-22 UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing... 105 7e-22 UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr... 105 7e-22 UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro... 105 1e-21 UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap... 104 2e-21 UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy... 104 2e-21 UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax... 103 2e-21 UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote... 103 3e-21 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 102 5e-21 UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin... 102 7e-21 UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap... 102 1e-20 UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon... 102 1e-20 UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin... 101 1e-20 UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p... 101 2e-20 UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote... 101 2e-20 UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin... 100 2e-20 UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote... 100 3e-20 UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 100 3e-20 UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte... 100 3e-20 UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu... 100 4e-20 UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon... 100 5e-20 UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul... 99 6e-20 UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu... 99 1e-19 UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 99 1e-19 UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte... 98 1e-19 UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact... 98 2e-19 UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo... 98 2e-19 UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein... 98 2e-19 UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob... 97 3e-19 UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero... 97 3e-19 UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ... 97 3e-19 UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte... 96 7e-19 UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T... 96 8e-19 UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap... 95 1e-18 UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm... 94 2e-18 UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros... 94 2e-18 UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu... 94 3e-18 UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo... 94 4e-18 UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte... 93 4e-18 UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom... 93 5e-18 UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid... 93 6e-18 UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact... 93 6e-18 UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob... 92 9e-18 UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin... 92 9e-18 UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte... 92 1e-17 UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote... 91 2e-17 UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte... 91 2e-17 UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell... 91 2e-17 UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap... 91 2e-17 UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax... 91 2e-17 UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein... 90 4e-17 UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch... 90 5e-17 UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom... 90 5e-17 UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 89 8e-17 UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing... 88 2e-16 UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi... 88 2e-16 UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1... 88 2e-16 UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo... 87 3e-16 UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo... 87 3e-16 UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte... 87 4e-16 UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom... 86 5e-16 UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote... 86 6e-16 UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu... 86 7e-16 UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob... 86 8e-16 UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl... 86 8e-16 UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz... 86 1e-15 UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter... 84 2e-15 UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=... 84 3e-15 UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo... 84 3e-15 UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu... 84 4e-15 UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul... 83 5e-15 UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T... 83 6e-15 UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob... 82 1e-14 UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ... 82 1e-14 UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph... 81 2e-14 UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu... 81 2e-14 UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing... 80 5e-14 UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 80 6e-14 UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo... 79 1e-13 UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros... 78 2e-13 UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan... 77 3e-13 UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph... 77 3e-13 UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax... 75 1e-12 UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico... 74 2e-12 UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha... 74 4e-12 UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor... 73 5e-12 UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo... 73 5e-12 UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo... 73 8e-12 UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri... 72 1e-11 UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin... 71 3e-11 UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T... 71 3e-11 UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo... 70 4e-11 UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph... 68 2e-10 UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap... 67 4e-10 UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi... 66 7e-10 UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph... 65 1e-09 UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=... 65 2e-09 UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu... 64 2e-09 UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther... 64 2e-09 UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell... 64 2e-09 UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov... 64 3e-09 UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk... 64 3e-09 UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha... 64 4e-09 UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact... 62 2e-08 UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote... 62 2e-08 UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu... 61 2e-08 UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob... 61 2e-08 UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos... 61 2e-08 UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha... 61 2e-08 UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl... 61 2e-08 UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta... 61 3e-08 UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=... 60 4e-08 UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos... 60 4e-08 UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot... 60 6e-08 UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu... 59 8e-08 UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury... 59 9e-08 UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta... 58 2e-07 UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1... 58 2e-07 UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm... 58 2e-07 UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost... 58 2e-07 UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo... 57 3e-07 UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto... 56 7e-07 UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C... 56 9e-07 UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor... 55 2e-06 UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha... 54 3e-06 UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 54 5e-06 UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo... 53 7e-06 UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot... 52 1e-05 UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo... 52 1e-05 UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul... 51 2e-05 UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins... 51 2e-05 UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto... 51 2e-05 UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob... 51 2e-05 UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha... 50 3e-05 UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh... 50 4e-05 UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br... 50 5e-05 UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost... 50 6e-05 UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=... 50 6e-05 UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot... 47 3e-04 UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph... 47 4e-04 UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re... 46 8e-04 UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom... 45 0.001 UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p... 45 0.002 UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha... 44 0.003 UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba... 43 0.007 UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc... 42 0.011 >UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria RepID=HIS2_VIBVY Length = 211 Score = 270 bits (690), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 131/197 (66%), Positives = 161/197 (81%), Gaps = 3/197 (1%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 ++WEK DGL+P IVQ S +VLM+GYMN +AL KT E+G+VTFFSRTK+RLWTKGETSG Sbjct: 15 INWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSG 74 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAH--QWLFLYQLEQLLAERK 126 N L +V+++ DCDNDTLLV NPIGPTCH GT++C+ GD Q ++L+QLEQLLA RK Sbjct: 75 NVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQLEQLLAARK 134 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 SADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT D+ EL E++DL+YHLLVLLQD Sbjct: 135 SADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIYHLLVLLQD 194 Query: 187 QGLDLTTVIENLRKRHQ 203 QGL + VI L++RH+ Sbjct: 195 QGLSMNDVINKLKERHK 211 >UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria RepID=HIS2_BLOFL Length = 213 Score = 228 bits (581), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 110/206 (53%), Positives = 149/206 (72%), Gaps = 5/206 (2%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT ++ + L+W K GL+P I+QH++SGEVLMLGYMN E++ T ++G VTFFSR+K R Sbjct: 1 MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KGE+SGN L +++ PDCD D+LL+L P G TCHK T+SCF + FL+QLE Sbjct: 61 LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120 Query: 121 LLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 +++ +K+ + ++SYT+ LY SG +RIAQKVGEEG+ETALAA + L +EASD Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201 L+YHLLVLLQ + L+ VI+ LR R Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVR 206 >UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria RepID=HIS2_XANCP Length = 206 Score = 226 bits (577), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 116/194 (59%), Positives = 136/194 (70%), Gaps = 2/194 (1%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LDW K DGL+PVIVQ A + VLMLGYMN EAL T G+VTFFSR+KQRLWTKGE+SG Sbjct: 15 LDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGESSG 74 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 N L VV+I DCD DTLLV A P GPTCH G +SCF Q FL L+ L+AER+ Sbjct: 75 NVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTAPSQ--FLGSLDALIAEREHER 132 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 P SYT KL+ G +RIAQKVGEEGVETALA V EL E++DL+YHL+VLL+ +GL Sbjct: 133 PHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRARGL 192 Query: 190 DLTTVIENLRKRHQ 203 L + L RH+ Sbjct: 193 GLGDAVALLESRHK 206 >UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=Q058A1_BUCCC Length = 205 Score = 212 bits (539), Expect = 7e-54, Method: Compositional matrix adjust. Identities = 95/203 (46%), Positives = 135/203 (66%), Gaps = 3/203 (1%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 ML +Q + L+W K +GL+P I QH +SGE+LM GYMN +A DK + + T +SR K+R Sbjct: 1 MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ--WLFLYQL 118 +W KGETS NFL V +I+ DCD D +LV NP G TCH SCF +++HQ + FLY+L Sbjct: 61 IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCF-ESSHQLPYTFLYKL 119 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 E + +K +SY + L++SG RIAQK+GEE VE +A ++ + NE SDL++ Sbjct: 120 ENRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIF 179 Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201 HL +LLQ ++L +I+NL+KR Sbjct: 180 HLFILLQSMNINLYKIIKNLQKR 202 >UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae RepID=C5SM65_9CAUL Length = 215 Score = 211 bits (536), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 109/194 (56%), Positives = 135/194 (69%), Gaps = 1/194 (0%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LD+ K DGL+P IVQ A + +VLMLGYM+ AL +TL +VTFFSR+K W KGETSG Sbjct: 19 LDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGRWRKGETSG 78 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-DTAHQWLFLYQLEQLLAERKSA 128 +FLN+VS+ DCD D LLVLA P+GPTCH T+SCFG DTA F+ L ++ +R A Sbjct: 79 DFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAAVVKDRAKA 138 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 P SYTA+L G +IAQKVGEEG+ETALA D EL NEA+DL+YHL VLL + Sbjct: 139 PPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHLSVLLMARD 198 Query: 189 LDLTTVIENLRKRH 202 L V++ LR+RH Sbjct: 199 TTLEAVLDILRERH 212 >UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT Length = 215 Score = 202 bits (514), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 98/197 (49%), Positives = 135/197 (68%), Gaps = 2/197 (1%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++D++K GL+P ++Q + VLMLGYMN EA KT+E+ KVTF+SR++ LWTKGETS Sbjct: 2 QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126 GN+L++VSI DCDNDTLLV +P GPTCH GT +C+G+T + LFL +L+ + R Sbjct: 62 GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 P+ SYT L+ G ++IAQKVGEE VET + A + L EASD++YHL+VLL Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181 Query: 187 QGLDLTTVIENLRKRHQ 203 +GL + + L +RH Sbjct: 182 KGLHIEDLARELARRHN 198 >UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria RepID=A9B1U1_HERA2 Length = 212 Score = 199 bits (506), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 103/197 (52%), Positives = 127/197 (64%), Gaps = 9/197 (4%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 + GL+P +VQHA SGEVLM+GYMN EAL KT SG VTF+SR++Q+LWTKGETSGN L Sbjct: 8 SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETSGNVLKF 67 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQLEQLLAER 125 ++ DCDND LL+LA P GPTCH G+ SCF T A F+ QL + L ER Sbjct: 68 IAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLFEFLRER 127 Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185 + P SYT L G +I +K+GEE E +AA + EL NEASDL+YHL VLL Sbjct: 128 EQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYHLFVLLL 187 Query: 186 DQGLDLTTVIENLRKRH 202 +QG+ V LR+RH Sbjct: 188 NQGVSPEDVWFTLRERH 204 >UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Legionella RepID=C6N0X1_9GAMM Length = 207 Score = 197 bits (501), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 95/193 (49%), Positives = 131/193 (67%), Gaps = 1/193 (0%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LDW+K +GL+P I+Q+A +G VLMLGYMN EAL T+ +G++T +SR+++RLW KGETSG Sbjct: 9 LDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGETSG 68 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-FLYQLEQLLAERKSA 128 N + V I+ DCD+D+LL++ P GP CH G +SC+ H + F+ L +++ ER Sbjct: 69 NTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINERAET 128 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 E SYTA+L ASG R AQKVGEE VET +AA E NE +DL++HLLVLL+ Sbjct: 129 QAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLKASE 188 Query: 189 LDLTTVIENLRKR 201 L V++ L+ R Sbjct: 189 LSFYDVLQCLQDR 201 >UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1 Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL Length = 207 Score = 197 bits (501), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 1/195 (0%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 +D+EK +GL+PV+VQ A + +VL L YM+ ALD+T++SG+ TFFSR++ W KGETSG Sbjct: 7 IDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGETSG 66 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-LYQLEQLLAERKSA 128 + L+VV I DCD+D L++ NP+G CH +SCFG L + +LEQ +AER +A Sbjct: 67 DRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERAAA 126 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 DP S+TAKL G KRIAQKVGEEGVETALA EL +EA+DL+YHLLVLL + Sbjct: 127 DPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHARN 186 Query: 189 LDLTTVIENLRKRHQ 203 + V++ L R + Sbjct: 187 MVFQDVLDVLASRAE 201 >UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase n=2 Tax=Francisella philomiragia RepID=B0TY40_FRAP2 Length = 207 Score = 195 bits (495), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 102/194 (52%), Positives = 136/194 (70%), Gaps = 3/194 (1%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 W+K D L+P I+Q A+ VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTKGE SGNF Sbjct: 11 WQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTKGEESGNF 70 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--GDTAHQWLFLYQLEQLLAERKSAD 129 L + IA DCDND++L+ A P GPTCH G+ SCF + + +LE+L+AE+K Sbjct: 71 LELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLIAEKKDYL 130 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD-RFELTNEASDLMYHLLVLLQDQG 188 PE SY L+ G RIAQKVGEEGVE +AA D EL +E +DL++HLLVLL+++G Sbjct: 131 PENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLLVLLREKG 190 Query: 189 LDLTTVIENLRKRH 202 + L + + L R+ Sbjct: 191 ISLEQICQKLVSRN 204 >UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes RepID=C6W0Y7_DYAFD Length = 213 Score = 190 bits (483), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 106/206 (51%), Positives = 136/206 (66%), Gaps = 12/206 (5%) Query: 10 LDWEKT-DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +D+ K+ DGL+P ++Q +G+VLMLGYMN EALD T + G VTFFSR+KQRLWTKGETS Sbjct: 8 IDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWTKGETS 67 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFL-YQ 117 GNFL V IA DCD DTLL+ A P GP CH G +CFG+ A + FL Y Sbjct: 68 GNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAAFLNYL 127 Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 ++++ ERK + SYT+ L+ G +IAQKVGEE VE + + D NE SDL+ Sbjct: 128 QKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNEVSDLL 187 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRHQ 203 +HLLVLL+ + +DL VI+ LR RHQ Sbjct: 188 FHLLVLLEQKNIDLDEVIDVLRSRHQ 213 >UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Flavobacteriales RepID=A4CLC1_9FLAO Length = 206 Score = 188 bits (478), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 98/203 (48%), Positives = 133/203 (65%), Gaps = 8/203 (3%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 + +D+EKT GL+P I+Q + + VLMLGYM+ EAL+ T SGKVTF+SR+K+RLWTKGE+ Sbjct: 2 KSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGES 61 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW--LFLYQLEQLLAER 125 SGNFL V + DCD D LL+ A P GP CH G+ +C+ D A+ FL +LE ++A R Sbjct: 62 SGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCW-DEANPGDEDFLPELEAIIASR 120 Query: 126 KS-AD----PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 K AD SY A L GT ++AQKVGEE VET + A D NE++DL++H Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 L+LLQ +G + + L +RH+ Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203 >UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR Length = 204 Score = 187 bits (476), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 95/203 (46%), Positives = 130/203 (64%), Gaps = 1/203 (0%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT Q +L+W+K + L+P+IVQ S E+LM GY N ++L TL+ K+TFFSRTK R Sbjct: 1 MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-FLYQLE 119 LWTKGETS N+L V+ I PDCD D+LL L IG TCH SCF + + F+ +LE Sbjct: 61 LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 ++L K + TSYT+ LY G +I+QKVGEE VE +AA D+ + E +DL+YH Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 +LVL + +I+ L+KR+ Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203 >UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B858_THEAS Length = 205 Score = 181 bits (460), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 95/199 (47%), Positives = 120/199 (60%), Gaps = 6/199 (3%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 ++W D L+PV+VQ A SG VLML Y N EALD TL+ G+ FFSR++ RLW KGETSG Sbjct: 5 IEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGETSG 63 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQLLAE 124 N + V+ + DCD D++L L GP CH G SCF G LFL++L +++ + Sbjct: 64 NTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIVDQ 123 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R S + SYT L+ G RIAQKVGEEGVE ALA DR EA+DL+YHL V L Sbjct: 124 RISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTVAL 183 Query: 185 QDQGLDLTTVIENLRKRHQ 203 + L + L RHQ Sbjct: 184 RRVDATLLDAEQVLMARHQ 202 >UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2 Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT Length = 233 Score = 176 bits (447), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 88/190 (46%), Positives = 122/190 (64%), Gaps = 5/190 (2%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P +VQH +G+VLMLGYM EA + T +GKVTFFSR+++++W KGETSGN L+V+ I Sbjct: 26 LIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSRKKIWVKGETSGNGLDVMDI 85 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLAERKSADPET 132 DCD DT+LVLA P+GPTCH G+ SCF + Q + +L+ + ERK+ DP+ Sbjct: 86 RWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFEVWSELQSTVRERKTGDPDI 145 Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192 SYTA L S + +K+ EE E +LA V R +E +DL +H+ V L+ G+ Sbjct: 146 SYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEWADLFFHIAVALEKTGVSWG 205 Query: 193 TVIENLRKRH 202 V+E LRKR Sbjct: 206 EVMEILRKRQ 215 >UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NG19_KYTSD Length = 244 Score = 175 bits (444), Expect = 7e-43, Method: Compositional matrix adjust. Identities = 100/229 (43%), Positives = 130/229 (56%), Gaps = 35/229 (15%) Query: 9 ELDWEK-TD---GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 E+D+ + TD GL+ +VQ A + VLM+G+M+ AL+ T +G+VTF+SR++ W K Sbjct: 15 EVDFSRVTDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVK 74 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF------------------- 105 GETSGN L+VVS+ DCD D +LV+A P GPTCH G +SCF Sbjct: 75 GETSGNTLDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAA 134 Query: 106 ------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEE 153 G T + L + +AER P SYT L+ GT+RIAQKVGEE Sbjct: 135 SGAGGDAPASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEE 194 Query: 154 GVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 GVETALA EL E++DL+YHL+VLL D+GL L V LR R Sbjct: 195 GVETALAGVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243 >UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria RepID=C6J1M1_9BACL Length = 231 Score = 175 bits (443), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 91/199 (45%), Positives = 124/199 (62%), Gaps = 12/199 (6%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ A S EVLML YMN E+L K++E+G+ F+SR++ LW KG TSGN + + Sbjct: 28 GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELWNKGATSGNTQQITA 87 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA------------HQWLFLYQLEQLLAE 124 + DCD DTLLV GP CH G +CF TA ++ L +LEQL+AE Sbjct: 88 LKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADERFKVLAELEQLIAE 147 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R + PE +YT L+ G +I +KVGEE E+ +AA D EL E SDL+YHLLVLL Sbjct: 148 RYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELRYEVSDLIYHLLVLL 207 Query: 185 QDQGLDLTTVIENLRKRHQ 203 +++ L L +++ L +RH+ Sbjct: 208 RERNLPLDEIMQELERRHE 226 >UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ Length = 211 Score = 172 bits (436), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 90/201 (44%), Positives = 121/201 (60%), Gaps = 14/201 (6%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V Sbjct: 8 DGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVT 67 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF------GDTAHQWLF--------LYQLEQL 121 S+ DCD DTLL L P GP CH G +SCF D + + F L L QL Sbjct: 68 SLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQL 127 Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 + +R P+ SY KL G ++ +KVGEE E A D+ E+ +E++DL++H L Sbjct: 128 IEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHTL 187 Query: 182 VLLQDQGLDLTTVIENLRKRH 202 + L+ +DL+ V++ L RH Sbjct: 188 LALKYFQVDLSEVLQELHNRH 208 >UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms RepID=C9RV77_GEOSY Length = 216 Score = 169 bits (429), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 97/195 (49%), Positives = 125/195 (64%), Gaps = 9/195 (4%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ A S EVL L YMN E+L+KTLE+G+ F+SR++Q LW KG TSGN VV Sbjct: 11 GLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGATSGNVQRVVD 70 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQLEQLLAERKS 127 I DCD D LLVL P GP CH G+ SCF + A ++ L +LEQ++A+R + Sbjct: 71 IRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNELEQIIAKRDA 130 Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187 PE SYT L+ G +I +KVGEE E +AA + EL EA+DL+YHLLVLL++Q Sbjct: 131 ERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLYHLLVLLREQ 190 Query: 188 GLDLTTVIENLRKRH 202 L L V+ L +RH Sbjct: 191 KLPLDAVLATLAERH 205 >UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB5_9BACT Length = 188 Score = 168 bits (426), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 88/188 (46%), Positives = 117/188 (62%), Gaps = 5/188 (2%) Query: 21 VIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPD 80 ++VQ A SGEVLML Y N E++ TLE G++ F+SR+++ +W KG TSGN L + S+ D Sbjct: 1 MVVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQID 60 Query: 81 CDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQLLAERKSADPETSYT 135 CD D +L +P+GP CH G SCF G+ +FL +L L +R PE SYT Sbjct: 61 CDCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYT 120 Query: 136 AKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI 195 A+L A R+AQK+GEEGVETALA DR + EA+DL+YHLLV L L + Sbjct: 121 ARLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIW 180 Query: 196 ENLRKRHQ 203 L+KRH+ Sbjct: 181 RELKKRHK 188 >UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4Y5_SPHTD Length = 228 Score = 167 bits (424), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 88/195 (45%), Positives = 121/195 (62%), Gaps = 9/195 (4%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGETSGN VV Sbjct: 23 GLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGETSGNVHEVVE 82 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF-------GDTA--HQWLFLYQLEQLLAERKS 127 I PDCD D LLV P GPTCH GT +CF G+ A + ++ +++AER++ Sbjct: 83 IRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDEVARVVAERRA 142 Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187 E SYT L +G +I +K+GEE E +AA D L NEA+DL+YHLLVLL+ Sbjct: 143 HPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLIYHLLVLLEAS 202 Query: 188 GLDLTTVIENLRKRH 202 + V LR R Sbjct: 203 DVPTERVWAVLRTRR 217 >UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes RepID=HIS2_OCEIH Length = 215 Score = 163 bits (413), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 82/191 (42%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ SG+VL L YMN +++ KT+E+ + F+SR +Q LW KG TSGN V Sbjct: 16 GLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQELWNKGATSGNKQTVKQ 75 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLAERKSADPE 131 I+ DCD D +LVL + GP CH G SCF + ++ + Q+ + ER E Sbjct: 76 ISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQIIPQVSAKIKERHEHPVE 135 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 +YT+ L+ G +I +K+GEE E +AA D+ ELT+E SDL+YH LVL++ QG+ L Sbjct: 136 GAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSDLLYHSLVLMEQQGVTL 195 Query: 192 TTVIENLRKRH 202 + + L KRH Sbjct: 196 EDIKKELYKRH 206 >UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga RepID=HIS2_THEMA Length = 197 Score = 161 bits (407), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L PV+VQ +GEVLML Y N EAL+ T ++G FFSR +Q++W KGETSGN + VV I Sbjct: 4 LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63 Query: 78 APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQW------LFLYQLEQLLAERKSAD 129 DCD+D L + + CH G SCF H++ F +L +L+ +RK Sbjct: 64 RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 PE SYT KL+ G +IA+K GEE VE +DR L E +D+MYHL VL+ D G+ Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183 Query: 190 DLTTVIENLRKRHQ 203 + V+ L KR + Sbjct: 184 TVQDVMRELEKRRK 197 >UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria RepID=C6PCK8_CLOTS Length = 228 Score = 160 bits (404), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 79/194 (40%), Positives = 116/194 (59%), Gaps = 8/194 (4%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ + EVLM+ YMN E+L+K+LE+ + FFSR++Q LW KGETSGN ++ + Sbjct: 18 GLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKGETSGNVQHIKA 77 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAERKSA 128 I DCD DTLLV P GP CH G +SCF + + L L + + RK Sbjct: 78 IKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSNLYRRIESRKEN 137 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 SYT L+ G +I +K+GEE E +A+ + E+ E +D +YHL+VL+ ++G Sbjct: 138 PVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYIYHLMVLMVEKG 197 Query: 189 LDLTTVIENLRKRH 202 ++L V + + KR+ Sbjct: 198 INLNDVYKEISKRY 211 >UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT Length = 230 Score = 160 bits (404), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 87/192 (45%), Positives = 115/192 (59%), Gaps = 8/192 (4%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L PV+ Q G+VLM+GYMN EA +T+E G+VTFFSR+++RLWTKGE+SG+FL +VS+ Sbjct: 16 LRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWTKGESSGHFLRLVSL 75 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCFG------DTAHQWLF--LYQLEQLLAERKSAD 129 DCD DTLL L P GPTCH GT SCF T + F L L +A R+ D Sbjct: 76 RYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETLGDLAGTIALRRDGD 135 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 PETSY A+L + + +K+ EE ET A D +E +DL++HLLV ++ Sbjct: 136 PETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMADLLFHLLVAMERTRT 195 Query: 190 DLTTVIENLRKR 201 V+ L KR Sbjct: 196 PWEEVVGVLEKR 207 >UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001910D6A Length = 157 Score = 159 bits (401), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 74/81 (91%), Positives = 77/81 (95%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR Sbjct: 77 MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136 Query: 61 LWTKGETSGNFLNVVSIAPDC 81 LWTKGETSG+ LNVVSIAPDC Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157 >UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae RepID=B4U8T9_HYDS0 Length = 207 Score = 153 bits (386), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 81/195 (41%), Positives = 115/195 (58%), Gaps = 8/195 (4%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PVI Q A SGE+ ML Y N EA+ KT+E+G +FSR++ +W KGETSG V+ Sbjct: 12 GLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGETSGELQEVLE 71 Query: 77 IAPDCDNDTLL-VLANPIGPTCHKGTSSCF---GDTAHQWLFLYQ----LEQLLAERKSA 128 I DCDNDTL+ ++ CH G +CF D L ++ LE+L+ +R S Sbjct: 72 IRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFLERLIKDRISN 131 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 E+SYT+KL G RI QKVGEE +E+ +A D+ E+ E +DL+YH+LV ++ Sbjct: 132 PVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIYHILVGIKYSN 191 Query: 189 LDLTTVIENLRKRHQ 203 + V L +RH+ Sbjct: 192 MSFEDVEFELIRRHK 206 >UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria RepID=B5EQF3_ACIF5 Length = 230 Score = 152 bits (385), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 84/198 (42%), Positives = 115/198 (58%), Gaps = 11/198 (5%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P I Q A SG VLML +MN +AL TL G T++SR++Q LW KGETSG+ ++ Sbjct: 19 ADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRKGETSGHIQHL 78 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--GDTAHQ-WL--------FLYQLEQLLA 123 V + DCD DTLL+ GP CH G +CF G Q W L L+ L Sbjct: 79 VDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGSILDSLQVTLH 138 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 R++ADP SY A+L G RI +KVGEE E +A H+ + EA+DL++HL+V Sbjct: 139 NRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEAADLVFHLMVA 198 Query: 184 LQDQGLDLTTVIENLRKR 201 L+++ L + V+ L +R Sbjct: 199 LEERDLHIDDVLGELARR 216 >UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae RepID=D0LRT4_HALO1 Length = 241 Score = 152 bits (385), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 85/201 (42%), Positives = 117/201 (58%), Gaps = 16/201 (7%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L V Sbjct: 24 GLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLAVRE 83 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF---------------GDTAHQWLFLYQLEQL 121 + DCD D ++V+A P GPTCH GT SCF G + L +LE + Sbjct: 84 LRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKLEGV 143 Query: 122 LAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 +A R+ SAD E SYT L G +I K+ EE E A +R E+ +E +DL++H+ Sbjct: 144 IAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLLFHV 203 Query: 181 LVLLQDQGLDLTTVIENLRKR 201 +V L + + L V L +R Sbjct: 204 MVGLAARDIALDEVWGELSRR 224 >UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI Length = 244 Score = 151 bits (382), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 86/211 (40%), Positives = 112/211 (53%), Gaps = 26/211 (12%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q ++S EVLML YMN EAL+ TL++G +FSR+KQR+W KGE SGN V Sbjct: 12 GLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSGNIQEVCE 71 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF----------------------GDTAHQWLF 114 I DCD+D++L+ N G CH G SCF D+ L Sbjct: 72 IKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKDSLTHSLN 131 Query: 115 LYQ----LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 Y L L ERK+AD TSYTA L+A GT IA+K+ EE E A D E+ Sbjct: 132 TYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKDRDSKEII 191 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +D+ YH+LV L + + + + L KR Sbjct: 192 YECADVFYHILVGLASENIHPDRIYQELIKR 222 >UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms RepID=HIS2_PYRFU Length = 209 Score = 149 bits (377), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 91/213 (42%), Positives = 126/213 (59%), Gaps = 14/213 (6%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M E+ +++WEK +G++PVIVQ GEVL L YMN EAL KTLE+G ++SR+K R Sbjct: 1 MEIEKLLEQVNWEKNNGIVPVIVQDE-KGEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF----GDTA------H 110 + KGE SGN V I DCDND LL++ +P GP CH G SCF G+ + Sbjct: 60 IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119 Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L +LE+++ RK E SYT+KL+ G ++I +K GEE +E +A R + Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVA---EKRERII 176 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E +DL+YHLLVLL + L V+ LR+R + Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209 >UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria RepID=HIS2_AQUAE Length = 205 Score = 149 bits (375), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 77/197 (39%), Positives = 117/197 (59%), Gaps = 9/197 (4%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+PVI Q +GEV ML Y N EA+ KTLE+G ++SR+++++W KGETSG V+ Sbjct: 9 EGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETSGELQKVI 68 Query: 76 SIAPDCDNDTLL-VLANPIGPTCHKGTSSCF-----GDTAHQWL---FLYQLEQLLAERK 126 + DCD D L+ V+ CH G +CF G+ + L L +L+ ++ E+ Sbjct: 69 EVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQDVIREKI 128 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 E SYTAKL + G +R+ QK GEE VET +A ++ E+ E++D++Y LV L Sbjct: 129 ERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYTFLVSLSV 188 Query: 187 QGLDLTTVIENLRKRHQ 203 G+D+ V+E L +R + Sbjct: 189 SGIDIKEVMEELIRRFK 205 >UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=10 Tax=Bacteria RepID=C0QVS5_BRAHW Length = 220 Score = 148 bits (373), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 76/190 (40%), Positives = 110/190 (57%), Gaps = 5/190 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IV + EVL L YMN E+L+ +++ K F+SR++Q LW KGETSGN+ ++ S Sbjct: 18 GLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQELWRKGETSGNYQHIQS 77 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-----HQWLFLYQLEQLLAERKSADPE 131 I DCDND L++ GP CH G+ SCF + ++ + +L +L+ RK E Sbjct: 78 IKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSIDKLYKLIEGRKINQTE 137 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 SYT L+ SG +I +KVGEE E + A E E SDL+YH LVL+ ++G+ + Sbjct: 138 GSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDLLYHSLVLMVEKGITI 197 Query: 192 TTVIENLRKR 201 + L R Sbjct: 198 NDIKNELASR 207 >UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3 Tax=Chloroflexi RepID=B9KXC5_THERP Length = 218 Score = 147 bits (372), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 88/200 (44%), Positives = 124/200 (62%), Gaps = 13/200 (6%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KGETSG+ L + Sbjct: 17 ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKGETSGHVLEL 76 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH---------QWLFLYQLEQLLAER 125 V + DCD D LL +P GPTCH G SCF DT L +L ++A R Sbjct: 77 VELRTDCDGDALLARVHPHGPTCHTGRPSCF-DTEPLVGTSQDPVNATILDELASIIAAR 135 Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185 SYT+ L +G RIA+K+GEE E +AA + + EA+DL+YHLLVLLQ Sbjct: 136 AVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLLYHLLVLLQ 195 Query: 186 DQGL---DLTTVIENLRKRH 202 G+ ++ V++ R RH Sbjct: 196 ASGVPAGEVWRVLQARRGRH 215 >UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5 Length = 229 Score = 147 bits (372), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 85/199 (42%), Positives = 113/199 (56%), Gaps = 15/199 (7%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P +VQ ++G+V ML YM E+L +TLE+G+ TFFSR++ LW KG TSGN L V S+ Sbjct: 10 LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF-------GDTAHQWLFLYQ--------LEQLL 122 DCD D LL+LA P GPTCH G++SCF GD + Q LE+ L Sbjct: 70 HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 RK++ SYT KL G I K+ EE E A A + +EA+D++YHLLV Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189 Query: 183 LLQDQGLDLTTVIENLRKR 201 L +G+ L V+ L R Sbjct: 190 GLASRGVPLRAVLSALASR 208 >UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIV8_9BACT Length = 234 Score = 147 bits (370), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 80/199 (40%), Positives = 116/199 (58%), Gaps = 15/199 (7%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P +VQ G +LML YMN EALD+TL++G V F+SR++++LW KGETSG++L Sbjct: 22 GLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSGHYLLCKR 81 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------GDTAHQWLFLYQLEQLL 122 + DCD D LLV A P GPTCH +CF G+ A+ +F +L +++ Sbjct: 82 VFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIF-DRLYEMV 140 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 +RK+ E SY + L G RI +KV EE E LA R E+ +E +DL++H +V Sbjct: 141 LQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADLIFHSIV 200 Query: 183 LLQDQGLDLTTVIENLRKR 201 L + +T + + L KR Sbjct: 201 ALGHCEIPMTAIQQELGKR 219 >UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1 Tax=Raoultella terrigena RepID=Q6U8A9_KLETE Length = 88 Score = 146 bits (369), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 71/83 (85%), Positives = 75/83 (90%) Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL Sbjct: 6 LLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHL 65 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 +VLLQDQ L L +I NL+ RHQ Sbjct: 66 MVLLQDQELSLQDIIANLKSRHQ 88 >UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms RepID=HIS2_THEP3 Length = 216 Score = 145 bits (365), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 78/201 (38%), Positives = 111/201 (55%), Gaps = 21/201 (10%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PVI Q + EVLM+ Y+ L K+LE+GKV +FSR++ +LW KGETSG+F + S Sbjct: 14 GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWLKGETSGHFQLIKS 73 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GD----------------TAHQWLFL 115 I+ DCD DTLL+ + CH G SCF G+ A L Sbjct: 74 ISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFDEQKVYEAENAKIL 133 Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 ++ ++ +R E SYT L+ G +I +KVGEE E + A D+ E+ E SD Sbjct: 134 QEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAKNRDKGEIVYEISD 193 Query: 176 LMYHLLVLLQDQGLDLTTVIE 196 L+YHLLVL+ ++G+ L + E Sbjct: 194 LIYHLLVLMVERGIKLEDIYE 214 >UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC Length = 251 Score = 142 bits (359), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 82/237 (34%), Positives = 122/237 (51%), Gaps = 40/237 (16%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + + ++DW+K GL+PV++Q +GEVLM+ YMN EAL+ T +G +FSR+K R+W K Sbjct: 3 ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------GDTAHQ----- 111 GE+SGN V S DCDNDTLL+ G CH G SCF G+ H+ Sbjct: 62 GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121 Query: 112 ----WLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 + L +L + +RK +ADP+ SY AKLY G +K+ EE E A A R Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181 Query: 167 ---------------------FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +++ E +DL++H++V L G+ ++ L +R+ Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238 >UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria RepID=Q2JWX9_SYNJA Length = 231 Score = 141 bits (356), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 82/195 (42%), Positives = 110/195 (56%), Gaps = 11/195 (5%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ + G VLM+ +MN E+L KTLE+G+ F+SR++Q LW KGETSG+ V Sbjct: 34 GLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQWVKQ 93 Query: 77 IAPDCDNDTLLVLANPIG-PTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAERKS 127 I DCD+D L++L +G CH G SCF GD L Q+ ++ R+ Sbjct: 94 IRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKARQ- 152 Query: 128 ADPET-SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 ADP SYT+ L A G I +K+GEE E +AA D+ L E +DL YH LV L Sbjct: 153 ADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVALAH 212 Query: 187 QGLDLTTVIENLRKR 201 +D+ V L+ R Sbjct: 213 HQVDIRDVYRQLQAR 227 >UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Picrophilus torridus RepID=Q6KZD6_PICTO Length = 204 Score = 138 bits (348), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 74/199 (37%), Positives = 113/199 (56%), Gaps = 13/199 (6%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DG++PV+VQ +G+VL L YM+ AL+ T+++G ++SR+ +R+ KGE SGN V Sbjct: 9 NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF----------GDTAHQWLFLYQLEQLLAE 124 + I DC++++LL+ GP CH G +SCF G+ + L +LE L+ + Sbjct: 69 MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R SYT L SG + I +KVGEE +ET LA+ R + E +DL+YHL+V L Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILASG---RDRIVYETADLLYHLIVFL 185 Query: 185 QDQGLDLTTVIENLRKRHQ 203 + L V+ L +R + Sbjct: 186 AFNNVSLFDVMNELNRRSK 204 >UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN Length = 215 Score = 137 bits (346), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 86/196 (43%), Positives = 114/196 (58%), Gaps = 7/196 (3%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++ LW KG SGN V Sbjct: 10 ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKGAISGNTQEV 69 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL--FLYQLEQLLAERKS 127 + + DCD D +L P GP CH G +CF +TA L L ++ + L R Sbjct: 70 LEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKVYRTLRSRLR 129 Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187 PE SY K++ +G RI +K+GEE E +AA R EL EASDL++HLL L + Sbjct: 130 ERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLFHLLFTLTEL 189 Query: 188 GLDLTTVIENLRKRHQ 203 GL + L +R+Q Sbjct: 190 GLSPQDLARVLWERNQ 205 >UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae RepID=C4V2J2_9FIRM Length = 235 Score = 136 bits (343), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 78/204 (38%), Positives = 114/204 (55%), Gaps = 19/204 (9%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ + +VLML YMN E+L+KT+E+G ++SR++Q+LW KGETSGN + Sbjct: 15 GLVPAIVQEE-NNQVLMLAYMNRESLEKTIETGFAWYYSRSRQKLWKKGETSGNVQRIKE 73 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFG-----DTAHQWLF-------------LYQL 118 I+ DCD DT+L+ G CH GT SCF D + + L L Sbjct: 74 ISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIPLIEKEEHPLTEVLASL 133 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 Q++ R+ E SYT L+ G +I +K+GEE ET +A+ + R ++ E DL Y Sbjct: 134 YQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASKNNIREDVLYEMGDLWY 193 Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202 H LVLL + ++E L++R+ Sbjct: 194 HCLVLLAYHNMTPEDLLEELKRRN 217 >UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta RepID=HIS2_ARATH Length = 281 Score = 136 bits (343), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 79/206 (38%), Positives = 117/206 (56%), Gaps = 24/206 (11%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL I Q+ +G VLM G++N EAL T+ S K TFFSR++ LWTKGETS NF+N++ Sbjct: 65 GLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTLWTKGETSNNFINILD 124 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-------------FLYQLEQLLA 123 + DCD D+++ L P GPTCH G +C+ + L LY LE +++ Sbjct: 125 VYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGNKLALTTLYSLESIIS 184 Query: 124 ERK--SADPE---TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT---NEASD 175 +RK S P+ S+T +L + K+ EE E L T+ D E++ +E +D Sbjct: 185 KRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADE--LCRTLEDNEEVSRTPSEMAD 241 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201 ++YH +VLL +G+ + V+E LRKR Sbjct: 242 VLYHAMVLLSKRGVKMEDVLEVLRKR 267 >UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms RepID=HIS2_THET2 Length = 214 Score = 135 bits (340), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 73/168 (43%), Positives = 100/168 (59%), Gaps = 13/168 (7%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGETSG+ VV Sbjct: 12 GLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVE 71 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF---------LYQLEQLLAERKS 127 + DCD D ++ P GP CH G +CF H+ L + Q+ + ER Sbjct: 72 VLLDCDGDAVVYRVLPQGPACHTGERTCF----HRALLEGEKDLGFVVGQVYATIKERLR 127 Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 PE SY A+++ +G RI +K+GEE E LAA + EL +EA+D Sbjct: 128 TLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAAD 175 >UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS Length = 257 Score = 133 bits (335), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 82/227 (36%), Positives = 115/227 (50%), Gaps = 42/227 (18%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I QH +G +LM+ +MN E+L T E + +FSR++Q+LW KGE SG+F V Sbjct: 16 GLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQKLWHKGEESGHFQTVYE 75 Query: 77 IAPDCDNDTLLV-LANPIGPTCHKGTSSCF-----------------------GDTA--- 109 I DCD D +++ + G CH G SCF GD A Sbjct: 76 IRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDAQLKDPTAIYGDNAKTE 135 Query: 110 --------HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161 Q L L QL+ ERK A+ +TSY + LY G +I +KVGEEGVET +AA Sbjct: 136 SHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINKILEKVGEEGVETIIAA 195 Query: 162 -------TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 T + +L E +DL +H +V+L L+ +I+ L +R Sbjct: 196 KDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDELGRR 242 >UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria RepID=HIS2_HELHP Length = 231 Score = 133 bits (335), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 73/213 (34%), Positives = 114/213 (53%), Gaps = 20/213 (9%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 R++DWE+ + L+P IVQ S ++LML Y + ++L+ +L++ +FSR+KQR+W KGE Sbjct: 6 RQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQKGEQ 64 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-----DTAHQ----------- 111 SG+ ++ + DCDND+L+ + +G CH G SCF D Q Sbjct: 65 SGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMPQKYP 124 Query: 112 ---WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + L L ++ +R+ + E SYTA L A G I +K+ EE E A D Sbjct: 125 IGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDKDEKA 184 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + E +DL YH+LV L + + V++ LR+R Sbjct: 185 IIYECADLFYHILVGLALEHITPERVLQELRRR 217 >UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2 Tax=Campylobacter RepID=B9D5P8_WOLRE Length = 329 Score = 133 bits (334), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 77/181 (42%), Positives = 102/181 (56%), Gaps = 29/181 (16%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++DW+K GL+P +VQ + SGEVLML YMN EAL+ +L++G +FSRTK R+W KGE S Sbjct: 2 KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61 Query: 69 GNFLNVVSIAPDCDNDTLLV-LANPIGPTCHKGTSSCF-------GDTAH------QWLF 114 GN + I DCDNDT+L+ + G CH G SCF GD ++ Q L Sbjct: 62 GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121 Query: 115 LYQLEQL--------------LAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159 QL Q + +RK +ADP+TSY A L+ G I +KVGEE E + Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181 Query: 160 A 160 A Sbjct: 182 A 182 >UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4L5_GEMAT Length = 207 Score = 133 bits (334), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 80/195 (41%), Positives = 112/195 (57%), Gaps = 5/195 (2%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++ LW KG TSG Sbjct: 10 LDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG-LWHKGATSG 68 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA- 128 + V+S+A DCD D +L GP CH GT+SCF DTA + L+ +A R+ + Sbjct: 69 HVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDTTIAARQQSL 128 Query: 129 --DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 D SYT +L R+ +K+GEE VE A A D T E +DL+YH LV L+ Sbjct: 129 RDDERPSYTQRLLTDRNLRL-KKLGEEAVELATACVDGDVERATEETADLLYHALVALRA 187 Query: 187 QGLDLTTVIENLRKR 201 G L V L +R Sbjct: 188 TGGTLDGVRGVLAQR 202 >UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium thermophilum RepID=Q67KI1_SYMTH Length = 210 Score = 132 bits (333), Expect = 5e-30, Method: Compositional matrix adjust. Identities = 82/199 (41%), Positives = 106/199 (53%), Gaps = 25/199 (12%) Query: 28 SGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLL 87 +G+VLM YMN EAL TLE+G ++SR++Q LW KG TSG+ V I DCD D+LL Sbjct: 3 TGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSLL 62 Query: 88 VLANPIGPTCHKGTSSCFG-----------DTAHQWL------------FLYQLEQLLAE 124 +L G CH+GT SCF DTA + L +L +LAE Sbjct: 63 LLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLAE 122 Query: 125 RKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 R++ DPE SYT++L+ G +K+GEE E LA DR L E +DL +H LV Sbjct: 123 RRAHPDPE-SYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181 Query: 184 LQDQGLDLTTVIENLRKRH 202 L DQGL V + L R Sbjct: 182 LVDQGLSPADVADQLASRR 200 >UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus acidocaldarius LAA1 RepID=B7DRK3_9BACL Length = 254 Score = 131 bits (330), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 80/239 (33%), Positives = 116/239 (48%), Gaps = 49/239 (20%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 ++ GL+PV+ Q A +GEVLM+ Y + EAL +TL +G ++SR+++ W KG TSGN Sbjct: 15 YDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRREYWRKGATSGNA 74 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-------------------------- 105 VV + DCD D +L P GP CH G +CF Sbjct: 75 QRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAADEGGAKDVGGGA 134 Query: 106 ----------GDTAHQ------W--LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIA 147 DT+ + W L +L ++ R P+ SYT L+ G +R+ Sbjct: 135 DVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTTYLFTHGAERMG 194 Query: 148 QKVGEEGVETALAATVHDR-----FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +K+GEE VE ALA +R E+ +E++DL+YHLLVL + G+ V L KR Sbjct: 195 KKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHPVDVWRTLEKR 253 >UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 RepID=C8WUY1_ALIAD Length = 256 Score = 131 bits (329), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 79/244 (32%), Positives = 113/244 (46%), Gaps = 54/244 (22%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 ++ GL+PV+ Q A +G+VLML Y + EAL +TL +G ++SR+++ W KG TSGN Sbjct: 12 YDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRAYWRKGATSGNV 71 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-------------------------- 105 VV + DCD D +L P GP CH G CF Sbjct: 72 QRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAADESGPDPHGAAG 131 Query: 106 -----------------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASG 142 G A L +L ++ R P+ SYT L+ G Sbjct: 132 AGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPDGSYTTYLFTHG 191 Query: 143 TKRIAQKVGEEGVETALAATVHDR-----FELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197 +R+ +K+GEE VE ALA +R E+ +E++DL+YHLLVL + G+ V + Sbjct: 192 AERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRHVGVQPADVWQV 251 Query: 198 LRKR 201 L KR Sbjct: 252 LEKR 255 >UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3 Tax=Clostridiales RepID=C4Z9Z2_EUBR3 Length = 427 Score = 130 bits (326), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%) Query: 1 MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56 +L + +L W +DG++PVIVQ + +VLML YMN EA + T+ SG++T++SR Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274 Query: 57 TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108 ++ LWTKG TSG+ V S+ DCD DT+L + +G CH +CF + Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334 Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + L + ++ +R E SYT + G I +K+G E E LAA D + Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 L E SD MYH ++L+ + + + L +R Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427 >UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD Length = 202 Score = 130 bits (326), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 76/197 (38%), Positives = 110/197 (55%), Gaps = 9/197 (4%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+ W KG TSG Sbjct: 7 LDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRG-PWHKGATSG 65 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA- 128 N VV++ DCD D +L GP CH GT +CFG +W L L+ LA R + Sbjct: 66 NVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFG--PGRWDALSALDDTLARRAAPA 123 Query: 129 ----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 D SYT +L R+ +K+GEE E A D EA+D++YH+LV + Sbjct: 124 ERPDDAPPSYTRRLLEDRNLRL-KKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVAV 182 Query: 185 QDQGLDLTTVIENLRKR 201 + GL L V L +R Sbjct: 183 RPLGLSLDDVKAVLARR 199 >UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii RepID=A8HTA8_CHLRE Length = 308 Score = 125 bits (314), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 75/222 (33%), Positives = 121/222 (54%), Gaps = 33/222 (14%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 L W+K + L+ VIVQH +GEV+M + + A+ +TL++G TF+SR++ W KGETSG Sbjct: 72 LKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCKGETSG 130 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----------------------G 106 +F+NV ++ DCD D+++ L++PIGP CH G +C+ G Sbjct: 131 HFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGAHDDGG 190 Query: 107 DTAHQWLFLYQLEQLLAERKSA------DPETSYTAKLYASGTKRIAQKVGEEGVETALA 160 D + L LE+ +A+R+ A + S+TA+L + + + +K+ EE E Sbjct: 191 DHVPRTTLLT-LERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGELCQT 248 Query: 161 ATVHD-RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + R +E +DL+YH +VL QG+ + V+ LRKR Sbjct: 249 LEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290 >UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms RepID=HIS2_SYNPX Length = 222 Score = 120 bits (301), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 70/198 (35%), Positives = 103/198 (52%), Gaps = 13/198 (6%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q + G VLM+ +MN E++ +TL SG+ ++SR++Q LW KG TSG+ + S Sbjct: 18 GLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQELWHKGATSGHTQTLRS 77 Query: 77 IAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWL------------FLYQLEQLLA 123 I DCD D LL+ G CH G SCF + Q +L +++ Sbjct: 78 IRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNALSPPADACTELFRVIE 137 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 R+ E SYT KL G +I +K+GEE E +A + E+ EA+D+++H+ V Sbjct: 138 SRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEEIAGEAADILFHMQVA 197 Query: 184 LQDQGLDLTTVIENLRKR 201 L G+ V E L R Sbjct: 198 LAHHGVSWRQVQEVLAAR 215 >UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU Length = 284 Score = 119 bits (299), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 75/218 (34%), Positives = 114/218 (52%), Gaps = 44/218 (20%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ I Q +G +LM G+ + +A+ TL + K TF+SR++ LW KGETSGNF+ V S Sbjct: 56 GLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCKGETSGNFIGVES 115 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF----------------GDTAHQWLF--LYQL 118 + DCD D+L+ L P GPTCH G +C+ G A + LY+L Sbjct: 116 VHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRHAAEEALTTLYEL 175 Query: 119 EQLLAERK----SADPETSYTAKLYASG---TKRIAQKVGE--------EGVETALAATV 163 E + R+ + D + S+T +L + K+I ++ GE EG E A Sbjct: 176 EATIEARRVEAVADDVKPSWTRRLLDNPELLCKKIREEAGELCQTWEENEGKEAA----- 230 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 TNE +D++YH +V+L QG+ ++ V+ LR+R Sbjct: 231 ------TNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262 >UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria RepID=C4XTP1_DESMR Length = 124 Score = 113 bits (283), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 54/96 (56%), Positives = 67/96 (69%), Gaps = 1/96 (1%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 D+ K GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+ Sbjct: 5 DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64 Query: 71 FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105 V S+ DCD DT+LVL I G CH+G SCF Sbjct: 65 VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCF 100 >UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum sp. NBC37-1 RepID=A6Q6T8_SULNB Length = 222 Score = 112 bits (281), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 +DW K + L+P I Q A + +VLML YMN EA + TL +G +FSR+KQR+W KGE+SG Sbjct: 3 IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115 + V + DCD DT+++ G CH G SCF DT + + Sbjct: 62 HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121 Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L + ERK+A E S+T KL + + K+ EE E +A ++ E++ Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL+YH LV L + + V + L +R Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207 >UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus ATCC 29799 RepID=A6P0M4_9BACE Length = 108 Score = 112 bits (281), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 49/88 (55%), Positives = 66/88 (75%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+PVI+Q A + EVLMLG+ N EA++ TL++ F+SR++Q+LW KGETSG+FL+V + Sbjct: 13 LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHFLHVERM 72 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD DTLL +P+GPTCH G SCF Sbjct: 73 VTDCDTDTLLYFCHPVGPTCHTGAKSCF 100 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 112 bits (279), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 50/98 (51%), Positives = 66/98 (67%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GL+PV+VQ V+ EVLML YMN EA +KTLE+G +T++SR++Q LW KG TSG+F V Sbjct: 263 ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQYV 322 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112 S+ DCDNDT+L +G CH G +CF W Sbjct: 323 GSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTW 360 >UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms RepID=HIS3_SOLUE Length = 126 Score = 108 bits (270), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 57/129 (44%), Positives = 80/129 (62%), Gaps = 7/129 (5%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LD+ K+DGL+ ++Q SG VLM+GYMN EA +KT+E+G TF+SR++++LW KGE+SG Sbjct: 3 LDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESSG 62 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 + L V I+ DCD D +LV GP CH+G SCF + L E +A+ + Sbjct: 63 HRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCF------FRRLDAGEWKVADNPTY 116 Query: 129 DPETSYTAK 137 DP Y K Sbjct: 117 DPGAVYGGK 125 >UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota RepID=HIS3_HALWD Length = 132 Score = 107 bits (266), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 53/121 (43%), Positives = 71/121 (58%), Gaps = 9/121 (7%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 +DGL+P I Q A SGEVLML Y++P AL +T E+G+ ++SR+++ LW KGETSG+ + Sbjct: 20 NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWKKGETSGHTQH 79 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133 + I DCD DT+L L G CH G SCF T L+ + DPET Sbjct: 80 IREIRADCDADTILYLVEQTGGACHTGHQSCFYRT---------LDGTEVTERVFDPETV 130 Query: 134 Y 134 Y Sbjct: 131 Y 131 >UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales RepID=HIS3_ERYLH Length = 125 Score = 105 bits (263), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 45/91 (49%), Positives = 61/91 (67%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +DGL+ +VQH + EVLM+ +MN +ALD T ++G FFSR++Q LW KG TSGN L V Sbjct: 21 SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAV 80 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD D +++L P GP CH G +CF Sbjct: 81 SQVLVDCDQDAVILLVEPAGPACHTGARTCF 111 >UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1 RepID=A3WCC9_9SPHN Length = 143 Score = 105 bits (263), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 47/89 (52%), Positives = 63/89 (70%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ +V + + EVL++ +MN +AL KT E+GKV F+SR++ LW KGETSGN L+V Sbjct: 37 GLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGNVLSVDE 96 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 I DCD D L++ A P GPTCH G +SCF Sbjct: 97 IRVDCDQDALVIYATPAGPTCHTGETSCF 125 >UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G191_ABIDE Length = 295 Score = 105 bits (261), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 48/92 (52%), Positives = 60/92 (65%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ +G VL + YMN E+L+ TL F+SR+++ LW KGETSGN+ +VVS Sbjct: 27 GLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGETSGNYQHVVS 86 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 I DCD D LLV G CH+G SCF DT Sbjct: 87 IEADCDYDALLVRVVRDGAACHRGNESCFDDT 118 >UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria RepID=HIS3_DINSH Length = 119 Score = 104 bits (259), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 44/89 (49%), Positives = 61/89 (68%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q W KGE+SG+ +V Sbjct: 14 GLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGESSGHVQTLVE 73 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD D LL+ GP CH +CF Sbjct: 74 MRVDCDRDCLLLQVRQEGPACHTNRRTCF 102 >UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268 RepID=C8PI34_9PROT Length = 336 Score = 104 bits (259), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 51/98 (52%), Positives = 62/98 (63%), Gaps = 1/98 (1%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++DW+K GL+P IVQ A G VLML YMN EAL TL +G +FSR+K R+W KGE S Sbjct: 2 KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61 Query: 69 GNFLNVVSIAPDCDNDTLLV-LANPIGPTCHKGTSSCF 105 G+ V S DCDND LL+ + G CH G SCF Sbjct: 62 GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCF 99 >UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050F746 Length = 123 Score = 103 bits (258), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 48/103 (46%), Positives = 67/103 (65%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 T + REL +DGL+PVIVQ + EVLM+ +M+ EA+++TL +G ++SR++Q W Sbjct: 13 TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 KGETSGN V S++ DCD D LL+ GP CH T +CF Sbjct: 73 VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCF 115 >UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria RepID=HIS3_SILST Length = 129 Score = 103 bits (258), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 43/89 (48%), Positives = 60/89 (67%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q SGE+LM+ +MN E++ KTLE+G+VT++SR++Q W KGE+SG+ +V Sbjct: 24 GLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQELVE 83 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD D LL + GP CH SCF Sbjct: 84 LRVDCDRDALLAMVRQTGPACHTNRRSCF 112 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 102 bits (255), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 69/194 (35%), Positives = 105/194 (54%), Gaps = 8/194 (4%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LD++K L+P IVQ +G VLML Y PE+L + K +FSR++ LW KG TSG Sbjct: 224 LDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNELWEKGLTSG 282 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLEQLLAERKSA 128 N +++I DCD DTL+ G CH SCF G +A+ L L+++ +R + Sbjct: 283 NQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSAN--FDLDVLDRVFEQRMQS 340 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 TS++ KL AS + +K+ EE E A D+ E+ EA+DL++ L + +G Sbjct: 341 QEVTSFSQKLLASDDLQ-QEKLREECEELIEA---DDQDEVRWEAADLIFFALARAKSKG 396 Query: 189 LDLTTVIENLRKRH 202 + + +I L R+ Sbjct: 397 VAASDIINELGARN 410 >UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae RepID=HIS3_FRAAA Length = 132 Score = 102 bits (254), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 46/89 (51%), Positives = 62/89 (69%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL P I Q +GEVLMLG+M+ EAL +TL +G+ T++SR++ W KG+TSG+ V S Sbjct: 22 GLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQWVRS 81 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 +A DCD D +LV + IGP CH GT +CF Sbjct: 82 VALDCDGDAVLVRVDQIGPACHTGTRNCF 110 >UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria RepID=Q2SLC2_HAHCH Length = 139 Score = 102 bits (253), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 43/89 (48%), Positives = 63/89 (70%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PVI Q A + +LM +MN EAL+KT+ + ++T++SR++QRLW KGETSG+ +VS Sbjct: 33 GLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWVKGETSGHVQRLVS 92 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 ++ DCD D +L L + G CH G +CF Sbjct: 93 MSFDCDGDAILCLVDQQGAACHTGRQTCF 121 >UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides RepID=Q03VY1_LEUMM Length = 132 Score = 102 bits (253), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 47/93 (50%), Positives = 60/93 (64%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+P ++ A + LMLGYMN E+ T +G+ F+SR +Q LW KGETSGN VV Sbjct: 14 NGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQELWHKGETSGNIQQVV 73 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 S+ DCD DTLL+ NP GP CH SCF +T Sbjct: 74 SMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNT 106 >UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class) RepID=HIS3_CLAMS Length = 138 Score = 101 bits (252), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 52/114 (45%), Positives = 71/114 (62%), Gaps = 8/114 (7%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P ++Q + EVLMLGYM+ EAL +TL +G+VTF+SR++ W KG+TSG+ V Sbjct: 28 DGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYWRKGDTSGHGQYVR 87 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 A DCD DT+LV + +G CH GT +CF D H L + R +AD Sbjct: 88 DAALDCDGDTVLVQVDQVGVACHTGTRTCF-DADH-------LHPVTGARPAAD 133 >UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13 RepID=B6BVA2_9PROT Length = 129 Score = 101 bits (251), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 47/90 (52%), Positives = 64/90 (71%), Gaps = 1/90 (1%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I+Q S +V+M+ +MN EAL KT+E+ + F+SR++ ++W KGE SGNF NVVS Sbjct: 13 GLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLKGEESGNFHNVVS 72 Query: 77 IAPDCDNDTLLVLAN-PIGPTCHKGTSSCF 105 I DCD D+LLV N G +CH G +SCF Sbjct: 73 ILVDCDIDSLLVKVNVKSGISCHTGRNSCF 102 >UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria RepID=HIS3_THICR Length = 147 Score = 101 bits (251), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 48/114 (42%), Positives = 64/114 (56%), Gaps = 8/114 (7%) Query: 5 QQRRELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56 QQ DWE +GL+P I Q S EVLM+ +MN AL +TLE+G+V ++SR Sbjct: 14 QQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSR 73 Query: 57 TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH 110 ++Q W KGE SG + + DCD D +L+L + GP CH G SCF H Sbjct: 74 SRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIH 127 >UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae RepID=HIS3_ACIC1 Length = 142 Score = 100 bits (250), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 45/89 (50%), Positives = 62/89 (69%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL P + Q +GEVLM+G+M+ EAL +TL +G+ T++SR++Q W KGETSG+ V S Sbjct: 22 GLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQWVKS 81 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 +A DCD DT+LV + IG CH G +CF Sbjct: 82 VALDCDGDTVLVKVDQIGAACHTGDRTCF 110 >UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria RepID=HIS3_CHRSD Length = 146 Score = 100 bits (250), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 47/99 (47%), Positives = 64/99 (64%), Gaps = 5/99 (5%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q SGEVLM+ +MN AL++TL +G+V ++SR++ + W KGE+SG +V+ Sbjct: 32 GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPWRKGESSGQVQQLVT 91 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAH 110 DCD DTLL+ + GP CH G SCF DTAH Sbjct: 92 AHLDCDGDTLLLGVDQQGPACHTGRRSCFYVALGADTAH 130 >UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=A4GIE4_9BACT Length = 132 Score = 100 bits (249), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 41/90 (45%), Positives = 64/90 (71%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P I Q +GEVLM+ +MN +L +TL +G++ ++SR+++ LW KG+TSG+ ++ Sbjct: 16 DGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKLI 75 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD D++LVL + G CH+GT SCF Sbjct: 76 ELRYDCDADSILVLVDQSGAACHEGTRSCF 105 >UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria RepID=HIS3_BIFLI Length = 136 Score = 100 bits (249), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 44/89 (49%), Positives = 61/89 (68%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ ++Q + EVLM+GYMN EAL +TL +G+VTF+SR++Q W KG+TSG+ V Sbjct: 26 GLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQYVKG 85 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 ++ DCD D LLV + +G CH G SCF Sbjct: 86 VSLDCDGDALLVEVDQVGAACHTGKRSCF 114 >UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms RepID=HIS3_STRTD Length = 112 Score = 100 bits (248), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 47/97 (48%), Positives = 64/97 (65%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +LD++K GL+PVIV +G+VLML YMN + TLE+ ++ ++SR++ LW KG TS Sbjct: 5 KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 G+F +V SI DCD DTLL+ G CH G SCF Sbjct: 65 GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCF 101 >UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4CVB3_9BACT Length = 128 Score = 99.8 bits (247), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 53/125 (42%), Positives = 71/125 (56%), Gaps = 10/125 (8%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P IVQ + VLM+ +MN +L+ TL++G + ++SR++Q+ W KGETSG+ VV Sbjct: 11 DGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGETSGHTQKVV 70 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL---LAERKSADPET 132 A DCD DTLL IG CH G SCF Y E + E K DPE Sbjct: 71 RWAVDCDADTLLFEVEQIGGACHTGFESCFFQA-------YSPEGTPLEITEEKLFDPEK 123 Query: 133 SYTAK 137 +Y +K Sbjct: 124 TYASK 128 >UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms RepID=HIS3_GEOSF Length = 126 Score = 99.4 bits (246), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 45/98 (45%), Positives = 64/98 (65%), Gaps = 1/98 (1%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++D++K GL+P ++Q SGEVLM+ +M+ + LD TL+ GK FFSRT+ + W KGE S Sbjct: 3 KIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGEES 62 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105 GN V+ + DCD DT+++ GP CH G SCF Sbjct: 63 GNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCF 100 >UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms RepID=HIS3_PELLD Length = 137 Score = 98.6 bits (244), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 44/89 (49%), Positives = 61/89 (68%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ +G+VLM+ +MN E+L+ TLE K ++SR++ +LW KGE+SGN +V Sbjct: 21 GLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLKGESSGNMQDVYD 80 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 I DCD DTL++ + IG CH G SCF Sbjct: 81 ILIDCDGDTLILKVSQIGGACHVGYHSCF 109 >UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3 Length = 140 Score = 98.6 bits (244), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 44/90 (48%), Positives = 59/90 (65%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+P I Q +G+VLML YMN E+L+ TL+ K ++SR++Q LW KG TSGNF V+ Sbjct: 20 NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLKGATSGNFQEVM 79 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 I+ DCD D +L+ G CH G SCF Sbjct: 80 QISIDCDADAILLKVKQKGGACHVGYYSCF 109 >UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria RepID=HIS3_BACCN Length = 101 Score = 98.2 bits (243), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 43/91 (47%), Positives = 61/91 (67%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 + GL+P IV + + EVLML YMN EA +KTL++ K F+SR++Q LW KG TSG+ +V Sbjct: 6 SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 S+ DCD D +++ N +G CH G +CF Sbjct: 66 KSLYLDCDQDAIVITVNQVGVACHTGEKTCF 96 >UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria RepID=HIS3_ACIAC Length = 141 Score = 97.8 bits (242), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 49/101 (48%), Positives = 63/101 (62%), Gaps = 5/101 (4%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 E+ W+ GL+PVI Q A +G+VLM +MN EAL KT E G+ +FSR++ RLW KGE S Sbjct: 18 EVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGEES 76 Query: 69 GNFLNVVSIAPDCDNDTLLV----LANPIGPTCHKGTSSCF 105 G+ V I DCDND +L+ L + G CH G SCF Sbjct: 77 GHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCF 117 >UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria RepID=B8J3P0_DESDA Length = 137 Score = 97.8 bits (242), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 43/92 (46%), Positives = 64/92 (69%), Gaps = 1/92 (1%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 + GL+P I Q SGEVLML YMN EA KTLE+G+ ++SR+++++W KG TSG+ V Sbjct: 21 SKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGHIQKV 80 Query: 75 VSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105 +++ DCD+DT+L+ + + G CH G +CF Sbjct: 81 LAVRLDCDSDTVLLFVDQVGGAACHTGRRTCF 112 >UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM Length = 151 Score = 97.8 bits (242), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 46/102 (45%), Positives = 64/102 (62%), Gaps = 3/102 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P + Q A +G+VLML +MN A++KTLE+G++T+FSR++ LW KG SGN +V Sbjct: 44 GLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVKGLASGNHQQLVE 103 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF---GDTAHQWLFL 115 DCD D LL G CH G SCF + A+Q ++L Sbjct: 104 ARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145 >UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPU9_FIBSS Length = 116 Score = 97.4 bits (241), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 46/96 (47%), Positives = 60/96 (62%), Gaps = 2/96 (2%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L P IVQ A G+VLM+ +MN EAL +T E G++ F+SR+++ W KG+TSGN + VV Sbjct: 21 LAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRSRKEYWHKGDTSGNVMTVVEW 80 Query: 78 APDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111 A DCD+D LL GP CH G SCF T + Sbjct: 81 AADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116 >UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii 'Deep ecotype' RepID=B4RV64_ALTMD Length = 133 Score = 97.1 bits (240), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 44/90 (48%), Positives = 60/90 (66%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+PVI Q S +VLM +M+ E+LD+TL +GK+ ++SR++Q LW KG +SG+ V Sbjct: 31 DGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWRKGSSSGHSQTVK 90 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 SIA DCD D LL + +G CH SCF Sbjct: 91 SIAADCDGDVLLAEVSQVGFACHTRRHSCF 120 >UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms RepID=HIS2_YEAST Length = 799 Score = 97.1 bits (240), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 11/204 (5%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT++ E+ ++ DGL +V L L Y + +++ K ++ G+ ++SR++ Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118 +W KGETSGN ++ I+ DCD+D L +V +G CH T SCFG+ H L L Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVG-FCHLETMSCFGEFKHG---LVGL 248 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 E LL +R PE SYT +L+ + + + K+ EE E A + EL+ EA+DL Y Sbjct: 249 ESLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFY 304 Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202 L L + L V NL +H Sbjct: 305 FALAKLVANDVSLKDVENNLNMKH 328 >UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria RepID=HIS3_CHLP8 Length = 137 Score = 95.9 bits (237), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 44/89 (49%), Positives = 59/89 (66%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ +G+VLM+ +MN E+L TLE K ++SR++ +LW KGE+SGN +V Sbjct: 21 GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWLKGESSGNMQDVHD 80 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 I DCD DTLL+ + G CH G SCF Sbjct: 81 IMIDCDGDTLLLKVSQKGGACHVGYHSCF 109 >UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured crenarchaeote RepID=Q702A1_9CREN Length = 115 Score = 95.9 bits (237), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 42/97 (43%), Positives = 62/97 (63%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +LD+ K DGL+PV+VQ + ++LML Y N A++ T+++G F+S ++ +LW KGE S Sbjct: 12 KLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWMKGEES 71 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 GN V I DCD D++L L + P CH G +CF Sbjct: 72 GNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCF 108 >UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria RepID=HIS3_RHOPS Length = 147 Score = 95.1 bits (235), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 41/89 (46%), Positives = 59/89 (66%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ + A SGEVLM+ +MN EAL+KT++SG+ ++SR+++RLW KGE+SG+ V+ Sbjct: 28 GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGHVQRVLE 87 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 I DCD D + + G CH G SCF Sbjct: 88 IRVDCDQDAVWLRVEQAGAACHTGRQSCF 116 >UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SGQ9_9ACTO Length = 444 Score = 94.4 bits (233), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 43/90 (47%), Positives = 59/90 (65%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+ +V+ SGEVLM+ +M+ EAL +TL +G+ T++SR++ W KG TSGN V Sbjct: 342 DGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQYVR 401 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 S+A DCD D LLV +G CH G +CF Sbjct: 402 SVALDCDGDALLVSVEQVGAACHTGQRTCF 431 >UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZDC3_9SPHI Length = 130 Score = 94.4 bits (233), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 46/101 (45%), Positives = 63/101 (62%), Gaps = 7/101 (6%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 +EK GL+PV+VQ SG+VLMLGY N AL +TL++G TF+S ++ LWTKG+TSG++ Sbjct: 15 FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74 Query: 72 LNVVSIAPDCDNDTLLVLANPIGP-TCH------KGTSSCF 105 L + I DCD D L+ +G CH + SCF Sbjct: 75 LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCF 115 >UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms RepID=C7NRL7_HALUD Length = 138 Score = 94.0 bits (232), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 42/87 (48%), Positives = 55/87 (63%) Query: 19 MPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIA 78 +P + Q A SG+VLML Y+ EALD+T E+G ++SR++ LW KGETSGN ++ I Sbjct: 31 LPAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETSGNVQHLKEIR 90 Query: 79 PDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD D LL + G CH G SCF Sbjct: 91 VDCDGDALLYVIEQDGGACHTGFQSCF 117 >UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF76_THET1 Length = 300 Score = 93.6 bits (231), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 42/90 (46%), Positives = 66/90 (73%), Gaps = 1/90 (1%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W KGETSG L+V Sbjct: 20 GLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLKGETSGRTLHVRE 79 Query: 77 IAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105 + P+C+ ++LL+L + P CH G SCF Sbjct: 80 LRPNCELNSLLILVDQRLPGACHTGHFSCF 109 >UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria RepID=HIS3_SALRD Length = 127 Score = 93.2 bits (230), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 42/90 (46%), Positives = 58/90 (64%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P IVQ A + +VLM+ YM E L +TL++G++ ++SR++Q W KG+TSG+ V Sbjct: 14 DGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQERWVKGQTSGHTQTVE 73 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD DTLL + G CH G SCF Sbjct: 74 EARLDCDGDTLLFRVHQEGGACHTGFRSCF 103 >UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ Length = 149 Score = 92.8 bits (229), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 44/93 (47%), Positives = 60/93 (64%), Gaps = 2/93 (2%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +DGL+P IV A SG VLM +MN +AL +T+ +G F+SR++ +LW KGE SGN L+V Sbjct: 29 SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88 Query: 75 VSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCF 105 + DCD D + +LA+ G CH G SCF Sbjct: 89 KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCF 121 >UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSK8_9BACT Length = 125 Score = 92.8 bits (229), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 46/83 (55%), Positives = 55/83 (66%), Gaps = 3/83 (3%) Query: 26 AVSG--EVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS-IAPDCD 82 AV G + M GYMN A++ TL G VTFFSRT +LW KGETSGN L + I DCD Sbjct: 40 AVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWKKGETSGNILRLRGDIYVDCD 99 Query: 83 NDTLLVLANPIGPTCHKGTSSCF 105 D+LL+ A P+G TCH G+ SCF Sbjct: 100 GDSLLINAEPVGSTCHTGSQSCF 122 >UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria RepID=HIS2_LEPBJ Length = 92 Score = 92.8 bits (229), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 48/89 (53%), Positives = 61/89 (68%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 FL QLE +L +RK P+ SYTA L+ G RI +KVGEE E +AA D+ ELT+EA Sbjct: 3 FLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEA 62 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL++HL VLL +Q L L V+E LRKRH Sbjct: 63 ADLLFHLQVLLVEQELSLQDVVEELRKRH 91 >UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FGM5_9RHOB Length = 120 Score = 92.4 bits (228), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 41/90 (45%), Positives = 58/90 (64%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+P +VQ + EVLM+ +MN +L+KT E+ TF+SR+++ LW KG TSGN V Sbjct: 14 NGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGLTSGNTQKVD 73 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD D +L+L P GP CH +CF Sbjct: 74 KVRFDCDRDCILLLVTPEGPACHTNRRNCF 103 >UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales RepID=HIS3_MYCBP Length = 115 Score = 92.4 bits (228), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 40/92 (43%), Positives = 60/92 (65%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 DGL+ +VQ SG+VLM+ +MN EAL +TL++ + T++SR++ W KG TSG+ + Sbjct: 14 NADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQH 73 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 V S+ DCD D +L+ + +G CH G SCF Sbjct: 74 VHSVRLDCDGDAVLLTVDQVGGACHTGDHSCF 105 >UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria RepID=HIS3_CORJK Length = 127 Score = 91.7 bits (226), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 42/90 (46%), Positives = 57/90 (63%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P IVQ +G+VLM+ +MN AL TL + K T++SR++Q W KGETSG+ V Sbjct: 32 DGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIKGETSGHTQRVE 91 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD DT+L+ G CH G +CF Sbjct: 92 EVRLDCDGDTVLLKIEQTGAACHTGNRTCF 121 >UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria RepID=HIS3_BURS3 Length = 138 Score = 91.3 bits (225), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 41/91 (45%), Positives = 60/91 (65%), Gaps = 1/91 (1%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+PVI Q A + +VLM +MN EAL KT+E+ + ++SR+++RLW KGE SG+ +V Sbjct: 20 NGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVH 79 Query: 76 SIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105 + DCD D +L+ + G CH G SCF Sbjct: 80 EVRLDCDEDVVLLKVEQVSGIACHTGRHSCF 110 >UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria RepID=HIS3_RHOPT Length = 151 Score = 91.3 bits (225), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 39/90 (43%), Positives = 61/90 (67%), Gaps = 1/90 (1%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ V+ A +G+VLM+ +MN EALD+T+++G+ ++SR+++RLW KGETSG+ V+ Sbjct: 31 GLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGHIQKVLE 90 Query: 77 IAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105 + DCD D + + + G CH G SCF Sbjct: 91 MRVDCDQDAVWIKVDQTGGAACHTGRHSCF 120 >UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R0U5_9PLAN Length = 310 Score = 90.9 bits (224), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 37/88 (42%), Positives = 58/88 (65%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P I Q +GEVLM+ +MN E+ +T+ +G+ ++SR++ +LW KGE SG+ V + Sbjct: 181 LLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESGHMQTVHGV 240 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD DT+L+ + +G CH+G SCF Sbjct: 241 YVDCDADTILLKVSQVGAACHEGFRSCF 268 >UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria RepID=HIS3_MESSB Length = 139 Score = 90.9 bits (224), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 45/92 (48%), Positives = 59/92 (64%), Gaps = 2/92 (2%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+ +V A G +LM+ +MN EAL KTLE+G ++SR++ LW KGETSGN +V Sbjct: 31 NGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGNLQHVE 90 Query: 76 SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105 SI+ DCD D +L V G TCH G SCF Sbjct: 91 SISTDCDQDAVLLKVRVGGEGATCHTGRRSCF 122 >UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C2AA Length = 132 Score = 90.9 bits (224), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 41/90 (45%), Positives = 58/90 (64%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P IVQ +G VLM+ +M+ AL T+ + + T++SR++ W KG TSG+F V Sbjct: 35 DGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWIKGLTSGHFQTVT 94 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 S+A DCD DT+L+ G CH G+ SCF Sbjct: 95 SLALDCDGDTVLMQVVQDGAACHTGSHSCF 124 >UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria RepID=B9QYY7_9RHOB Length = 159 Score = 90.1 bits (222), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 43/92 (46%), Positives = 57/92 (61%), Gaps = 2/92 (2%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+ +V + EVLM+GYMN EAL +T+E+G+ ++SR+++ W KGETSG V Sbjct: 36 DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQIQKVQ 95 Query: 76 SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105 I DCD D L+ V G TCH G SCF Sbjct: 96 EILTDCDQDALVVKVTVEGNGATCHVGYRSCF 127 >UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XNB8_HIRBI Length = 139 Score = 89.7 bits (221), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 41/92 (44%), Positives = 57/92 (61%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 +DGL+ I Q S EVLML +MN +AL T+E+G+ ++SR++ +LW KG+TSG + Sbjct: 30 NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 V SI DCD D +L+ CH G SCF Sbjct: 90 VESIHTDCDQDAILLKVRQTDGACHTGRVSCF 121 >UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis RepID=HIS2_ZYMMO Length = 107 Score = 89.7 bits (221), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 43/87 (49%), Positives = 57/87 (65%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L +E ++AER+ A PE SY + L+ GT IAQKVGEE VET +AA D+ L +EA+ Sbjct: 6 LAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSLESEAA 65 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL++HL VLL D+G V LR+R Sbjct: 66 DLIFHLAVLLADRGSSFENVFSELRRR 92 >UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA Length = 126 Score = 89.4 bits (220), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 40/88 (45%), Positives = 55/88 (62%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P I Q A +G VLML +MN EA D+T+ + +FSR++ +LW KG+TSG+ V I Sbjct: 21 LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD DT+L+ G CH+ SCF Sbjct: 81 RVDCDADTILLSVEQTGAACHENYESCF 108 >UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae RepID=HIS3_ZYMMO Length = 124 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 35/89 (39%), Positives = 59/89 (66%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ ++ A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ + + Sbjct: 19 GLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHVMKIQE 78 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 I DCD DTL + P+GP CH G SCF Sbjct: 79 IRIDCDQDTLWLKVIPMGPACHTGAQSCF 107 >UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KWI3_HALNC Length = 124 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 43/88 (48%), Positives = 58/88 (65%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L QL ++ +RK ADP +SY A+L+A G +IAQKVGEEGVE ALAA D + +E Sbjct: 9 LLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDNVAIVSEM 68 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL +H +VLL D GL V++ L +R Sbjct: 69 ADLWFHSMVLLADAGLSHQAVLDELGER 96 >UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria RepID=Q2PPB3_PHANO Length = 881 Score = 87.8 bits (216), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/187 (34%), Positives = 100/187 (53%), Gaps = 11/187 (5%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 ++ DGL +V G L L Y + E++ ++L +G+ + SR K+ LW KGE+SG+ Sbjct: 202 DRPDGLYTTLVTDE-RGVALGLVYSSEESVAESLRTGRGVYQSR-KRGLWYKGESSGDIQ 259 Query: 73 NVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131 +VS++ DCD+D L + G CH T +CFGD + L +L++ L RK + P+ Sbjct: 260 ELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQKTLQSRKESAPQ 315 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 SYTA+L+ + + + K+ EE E A T + + EA+DL Y L G+ L Sbjct: 316 GSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFALTKCVAAGVSL 371 Query: 192 TTVIENL 198 V NL Sbjct: 372 EDVERNL 378 >UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae RepID=HIS3_PYRCJ Length = 128 Score = 87.4 bits (215), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 39/102 (38%), Positives = 61/102 (59%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 + L++ G + +VQ +GEVLM+G+M+P A+ TL +G ++S +++R+W KGET Sbjct: 17 KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109 SG++ V DCD D +++ IG CH G SCF A Sbjct: 77 SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSPA 118 >UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R0N1_9RHOB Length = 156 Score = 87.0 bits (214), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 42/92 (45%), Positives = 57/92 (61%), Gaps = 2/92 (2%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+ V SGE+LM+GYMN E+L +T+E+G+ ++SR++Q W KG TSG V+ Sbjct: 32 NGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEYWKKGGTSGQVQEVI 91 Query: 76 SIAPDCDNDT--LLVLANPIGPTCHKGTSSCF 105 I DCD D L V + G TCH G SCF Sbjct: 92 EIRTDCDQDAIWLRVKVHGNGATCHVGYRSCF 123 >UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria RepID=HIS3_RALEJ Length = 135 Score = 86.7 bits (213), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 52/129 (40%), Positives = 71/129 (55%), Gaps = 15/129 (11%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+PVIVQ + +VLM +MN +AL KT E G+ F+SR+++RLW KGE SG+ V Sbjct: 14 NGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRLWHKGEESGHVQKVH 73 Query: 76 SIAPDCDNDTLLVLANPI-GPTCHKGTSSCF-----GDT-AHQWLFLYQLEQLLAERKSA 128 + DCD D +L+ + CH G SCF GD + W +E +L Sbjct: 74 EMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEGDAESGDW---QTVEPVL-----K 125 Query: 129 DPETSYTAK 137 DP YTAK Sbjct: 126 DPSQIYTAK 134 >UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HFX2_CHAGB Length = 817 Score = 86.3 bits (212), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 66/188 (35%), Positives = 98/188 (52%), Gaps = 14/188 (7%) Query: 13 EKTDGLMPVIV--QHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ DGL+P +V +H + L L Y + E++ + L++ + SR K+ LW KG TSG+ Sbjct: 204 DRADGLIPTVVVDEHDTA---LGLVYSSEESVGEALKTQTGVYQSR-KRGLWYKGATSGD 259 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130 +V I+ DCDND L + G CH S CFGD L +LE L RK + P Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDLKG----LAKLESTLLSRKQSAP 315 Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190 SYTA+L+ S K + K+ EE E A T + + EA+DL+Y L G+ Sbjct: 316 AGSYTARLF-SDEKLLRAKIMEEAEELCDANTPEN---VAFEAADLIYFALTKAVGAGVT 371 Query: 191 LTTVIENL 198 L + ++L Sbjct: 372 LADIEKSL 379 >UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria RepID=C7RQA3_9PROT Length = 142 Score = 86.3 bits (212), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 38/89 (42%), Positives = 57/89 (64%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ I Q + E+LML +MN A+++TL +G ++SR+++ +W KGETSG V+ Sbjct: 29 GLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRKGETSGCRQRVIE 88 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD D +L+L + +G CH G SSCF Sbjct: 89 TRFDCDGDAILLLVDQLGGACHTGRSSCF 117 >UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter necessarius RepID=B1XSV4_POLNS Length = 140 Score = 85.9 bits (211), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 41/90 (45%), Positives = 58/90 (64%), Gaps = 1/90 (1%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PVI Q S ++LM+ +MN +AL +TL G+ +++R++Q+LW KGE SG+ V Sbjct: 32 GLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHKGEESGHTQKVKE 91 Query: 77 IAPDCDNDTLLVLA-NPIGPTCHKGTSSCF 105 I DCD DT+L+L G CH G SCF Sbjct: 92 IHLDCDGDTILLLVEQKDGIACHTGEHSCF 121 >UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae RepID=HIS3_GLUOX Length = 156 Score = 85.9 bits (211), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 40/91 (43%), Positives = 59/91 (64%), Gaps = 1/91 (1%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GL+ + Q A G VLML +MN +AL +TL +G+V ++SR++Q+LW KGETSG + Sbjct: 42 ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKLWRKGETSGQQQKL 100 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 + DCD D +L++ + G CH G SCF Sbjct: 101 IEARLDCDMDAVLMIVDQTGVACHTGRRSCF 131 >UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris BL2 RepID=B8EQR3_METSB Length = 141 Score = 85.9 bits (211), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 42/92 (45%), Positives = 55/92 (59%), Gaps = 2/92 (2%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+ + + A GE+LM+ YMN EAL TL +G+ ++SR++Q +W KG TSG V Sbjct: 31 DGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKVR 90 Query: 76 SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105 I DCD D LL + A G CH G SCF Sbjct: 91 EIRADCDQDALLLTIEAGGDGGACHTGRRSCF 122 >UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces RepID=HIS2_SCHPO Length = 417 Score = 85.5 bits (210), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/192 (33%), Positives = 100/192 (52%), Gaps = 11/192 (5%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 ++ DGL +V + + G L L Y + E++ ++L++G + SR K+ LW KG +SG Sbjct: 206 DREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSR-KRGLWYKGASSGAVQ 263 Query: 73 NVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131 +++ I DCD D L + G CH T CFG + L QLE+ L +RK+ PE Sbjct: 264 HLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASG----LCQLEKTLIDRKNNAPE 319 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 SYTA+L+ S K + K+ EE E A T + + E +DLMY + G+ L Sbjct: 320 GSYTARLF-SDPKLLRAKIMEEAEELCDATTKEN---VIWEMADLMYFAITRCVGSGVSL 375 Query: 192 TTVIENLRKRHQ 203 + +L +H+ Sbjct: 376 NDISRHLDLKHR 387 >UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT Length = 116 Score = 84.3 bits (207), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 39/89 (43%), Positives = 55/89 (61%), Gaps = 1/89 (1%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P I Q G VLM+ +MN E++ KTL +G+ ++SR++ +LW KG TSG+ V + Sbjct: 18 LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKGATSGHIQKVKEL 77 Query: 78 APDCDNDTLLVLANPIGP-TCHKGTSSCF 105 DCD DT+L+ IG CH G SCF Sbjct: 78 FYDCDGDTILLKVEQIGDIACHTGARSCF 106 >UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41B27 Length = 137 Score = 84.0 bits (206), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 34/88 (38%), Positives = 57/88 (64%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+ + Q + +VLM+ +MN EA+++TL++ K ++S ++Q+ W KGE+SGN V + Sbjct: 14 LVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKGESSGNVQTVKEM 73 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD D +++ + IG CH+G SCF Sbjct: 74 YIDCDADAIIMKVDQIGAACHEGYRSCF 101 >UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT Length = 127 Score = 84.0 bits (206), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 43/119 (36%), Positives = 66/119 (55%), Gaps = 6/119 (5%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P ++ A G+ L L YMN +A+ KT+E+GK+ F R++ RL KGETSG+ +V Sbjct: 13 GLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLKGETSGHIQSVKR 72 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL-LAERKSADPETSY 134 I DC+ ++L+ + CH G SC+ ++ Q + + E K DPE Y Sbjct: 73 IYFDCEGNSLVFMVEQHVAACHAGYKSCYYRE-----YIPQTNSIQVVEEKVFDPENVY 126 >UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms RepID=HIS3_PSEU2 Length = 130 Score = 83.6 bits (205), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 39/98 (39%), Positives = 58/98 (59%), Gaps = 2/98 (2%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 E+ W +DGL+P I Q +G VLM+ +MN EAL T + ++SR++ +LW KGE S Sbjct: 7 EIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGEES 65 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105 G+ + + DCD D ++++ IG CH G SCF Sbjct: 66 GHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCF 103 >UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms RepID=HIS3_METTH Length = 138 Score = 83.2 bits (204), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 37/88 (42%), Positives = 54/88 (61%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+ + Q +GEVLM+ YMN EAL +TLE+G ++S ++ +LW KGE+SG+ V + Sbjct: 23 LIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQRVKDV 82 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF 105 DCD D +++ G CH G SCF Sbjct: 83 LVDCDGDAVVLKVEQEGGACHTGYRSCF 110 >UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira pseudonana RepID=B8BUA9_THAPS Length = 272 Score = 82.8 bits (203), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 59/193 (30%), Positives = 95/193 (49%), Gaps = 13/193 (6%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 ++ DGL +V SGE L L Y + E++ L+SG+ ++SR++ LW KG+TSG+F Sbjct: 62 DRGDGLYTTVVS-TRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSGHFQ 120 Query: 73 NVVSIAPDCDNDTLLVL----ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 + + DCD D L + I CH T +C+G+ L LE L +R Sbjct: 121 TLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEPRG----LRHLEGTLQQRLKD 176 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 P SYT +L+ + K+ EE E + A T + + E +D++Y +V G Sbjct: 177 APVGSYTKRLFEDEI-LLRDKLVEEAQELSEADT---KQHVAEELADVLYFAMVRAAKAG 232 Query: 189 LDLTTVIENLRKR 201 + + +E L +R Sbjct: 233 VSIDDAVEELDRR 245 >UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales RepID=HIS3_RHISN Length = 152 Score = 82.0 bits (201), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 40/91 (43%), Positives = 54/91 (59%), Gaps = 2/91 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ +V A GE+LM+ +MN EAL T+E+G ++SR++ LW KGE+SGN V Sbjct: 29 GLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGNTQAVQE 88 Query: 77 IAPDCDNDTLLVLANPIG--PTCHKGTSSCF 105 I DCD D + + G TCH G SCF Sbjct: 89 IRTDCDQDAIWLKVTVAGHDATCHTGRRSCF 119 >UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI Length = 161 Score = 82.0 bits (201), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 43/92 (46%), Positives = 59/92 (64%), Gaps = 2/92 (2%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+PV+ A +GEVLM YMN EAL KT+E+G+ ++SR++Q+LW KG++SG V Sbjct: 27 NGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGLVQKVQ 86 Query: 76 SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105 +A D D D L V G +CH G SCF Sbjct: 87 QLAIDDDQDCLWMQVEVAGSGASCHVGYRSCF 118 >UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria RepID=HIS2_MAGSA Length = 109 Score = 81.3 bits (199), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 42/88 (47%), Positives = 56/88 (63%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +L ++A RK DP+ SYTAKL+A G +IAQK GEE VET +AA + EL E+ Sbjct: 7 ILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDELVGES 66 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +D +YHLLVL D G++ V L +R Sbjct: 67 ADTLYHLLVLWADCGVEPAKVWAELARR 94 >UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN Length = 477 Score = 80.9 bits (198), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/193 (33%), Positives = 95/193 (49%), Gaps = 10/193 (5%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 L ++ D L +V +G L L Y + E++ + SG+ ++SR++ LW KGE+SG Sbjct: 249 LRTDRPDSLFTTVVADE-AGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKKGESSG 307 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 N ++ I DCD+D L N G CH T +C+G L LE +L R Sbjct: 308 NAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHDGG----LRALESMLFSRHEN 363 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 P SYT +L+ + + K+ EE E A A +V D + EA+D+MY +V G Sbjct: 364 APAESYTKRLF-DDAELLRNKLVEEAQELAEAESVPD---VAGEAADVMYFAMVRCVAAG 419 Query: 189 LDLTTVIENLRKR 201 L+ V L KR Sbjct: 420 CKLSDVERMLDKR 432 >UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58 RepID=Q1NG03_9SPHN Length = 157 Score = 79.7 bits (195), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 42/92 (45%), Positives = 56/92 (60%), Gaps = 1/92 (1%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GLMP IV +A VLMLGYMN EAL +TL + + F+SR+++ LW KGE SG V Sbjct: 25 AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGFRQRV 84 Query: 75 VSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105 + D D D L+++ P +CH G SCF Sbjct: 85 DHVLVDDDQDALILMVTIDAPGSCHVGFRSCF 116 >UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta proteobacterium KB13 RepID=B6BVA1_9PROT Length = 104 Score = 79.7 bits (195), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 36/87 (41%), Positives = 59/87 (67%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L +L+QL+ +K +DP SYTAKL++ G + I +K GEE +E +A+ ++ + NE++ Sbjct: 4 LDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVINESA 63 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 D++YHLLVLL ++ + L VI L +R Sbjct: 64 DVLYHLLVLLSEKSVTLKEVISELERR 90 >UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae RepID=HIS3_SULSO Length = 85 Score = 78.6 bits (192), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 35/73 (47%), Positives = 47/73 (64%) Query: 33 MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92 M+G MN EAL KTL +G + F+S ++++LW KGETSGNF + DCD D +L Sbjct: 1 MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60 Query: 93 IGPTCHKGTSSCF 105 +GP CH G +CF Sbjct: 61 LGPICHTGNYTCF 73 >UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira RepID=B5VZW9_SPIMA Length = 200 Score = 77.8 bits (190), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 58/195 (29%), Positives = 89/195 (45%), Gaps = 32/195 (16%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW--------TKGETS 68 GL+ + +Q ++G VL LG MN EAL KTL + ++ + +++ LW + Sbjct: 30 GLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHPDIILESISYDYR 89 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 GNFL V +A C + G T L L +++ +R+ Sbjct: 90 GNFL-VAGVA-----------------YCPSELNGSGGHT------LAGLFRVICDRRDH 125 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 SYT +L+A G +I +K+GEE E +A + + +E +DL YH LV L Sbjct: 126 PNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAYHQ 185 Query: 189 LDLTTVIENLRKRHQ 203 +DL V E L R Q Sbjct: 186 VDLRKVYEQLEARRQ 200 >UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae RepID=HIS3_METS3 Length = 132 Score = 77.0 bits (188), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 37/99 (37%), Positives = 59/99 (59%), Gaps = 3/99 (3%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 R E++ +K ++ I Q +G++LM+ MN +AL KT+E+GK ++S ++ W KGE Sbjct: 6 RHEINGQK---VITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLKGE 62 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 +SG+ V I DCD D +++ G CH+G SCF Sbjct: 63 SSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCF 101 >UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria RepID=HIS2_BRUA1 Length = 107 Score = 77.0 bits (188), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 40/87 (45%), Positives = 57/87 (65%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L LE+++AER S TSYTA L A G + AQK+GEE VET +AA DR + +E++ Sbjct: 6 LADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVVSESA 65 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL+YHL V+ G+ L V++ L++R Sbjct: 66 DLLYHLAVVWNIAGVALEDVLQELQRR 92 >UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001744401 Length = 141 Score = 75.5 bits (184), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 1/92 (1%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P I + E LM+ YMN E L T+ G+ ++SR+++ +W KG+TSG F V Sbjct: 31 ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGEFQVV 90 Query: 75 VSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105 I DCD D +++ + G CH +CF Sbjct: 91 KEIRVDCDQDAVILKVEQLGGGCCHTKAPTCF 122 >UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HIS3_IGNH4 Length = 129 Score = 74.3 bits (181), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 38/97 (39%), Positives = 57/97 (58%), Gaps = 1/97 (1%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 L++ D + + Q SG+VLM+ MN EA+ KTL +G V ++S++++ LW KG TSG Sbjct: 16 LNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGATSG 75 Query: 70 NFLNVVSIAPDCDNDT-LLVLANPIGPTCHKGTSSCF 105 + + DCD D+ LLV+ CH+G SCF Sbjct: 76 HVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCF 112 >UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales RepID=HIS3_METVS Length = 136 Score = 73.6 bits (179), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 31/75 (41%), Positives = 46/75 (61%) Query: 31 VLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLA 90 VLM +M+ E+L TL++G + +FS ++ ++W KGE S N V+ + DCD D LL + Sbjct: 43 VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWMKGEESKNVQKVLEVFKDCDGDALLFIV 102 Query: 91 NPIGPTCHKGTSSCF 105 G CH+G SCF Sbjct: 103 EQTGWACHEGYMSCF 117 >UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN Length = 198 Score = 73.2 bits (178), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 53/187 (28%), Positives = 87/187 (46%), Gaps = 12/187 (6%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I+Q + G VL L +M+ ++L KT E +V + L + +G + Sbjct: 24 GLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLLITGWRYD--- 80 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTA 136 P C + +LV I ++ F + L ++ +++ +R+ E SYT Sbjct: 81 --PACQSLLILVECGSIAEPQNE-----FAQVSSN--LLSEVFEVICDRRDHPQEDSYTC 131 Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 KL A G +I +K+GEE E +A D + +E +DL YH LV + DL V Sbjct: 132 KLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAYHRADLRQVYR 191 Query: 197 NLRKRHQ 203 L +R + Sbjct: 192 KLAERRR 198 >UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum ATCC 11170 RepID=HIS2_RHORT Length = 117 Score = 73.2 bits (178), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 36/84 (42%), Positives = 51/84 (60%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L ++A R+ ADP TSYTAKL+ G +I QK GEE E +AA V ++ E++D++ Sbjct: 20 LAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAESADVL 79 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 YHL+VL D G+ V L +R Sbjct: 80 YHLMVLWADVGVTPDRVWAELARR 103 >UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota RepID=Q4P7D9_USTMA Length = 896 Score = 72.8 bits (177), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 13/200 (6%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 L ++TDGL V + L L Y +P ++ K++ +G + SR + LW KGE+SG Sbjct: 201 LTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-LWHKGESSG 259 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPT-----CH-KGTSSCFGDTAHQWLFLYQLEQLLA 123 VVSI DCD+D + T CH + CF L +LE L Sbjct: 260 ATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSATG----LAKLEATLK 315 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 R P SYTA+L+ + + K+ EE E A A +D+ + EA+DL+Y L Sbjct: 316 HRLQTAPAGSYTARLF-NDASLLGAKLREEAAELA-DANNNDKKHVAFEAADLIYFALTK 373 Query: 184 LQDQGLDLTTVIENLRKRHQ 203 G+ L + +L + + Sbjct: 374 CVSAGIGLEEIEASLDAKAK 393 >UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=B0MMD1_9FIRM Length = 114 Score = 72.4 bits (176), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 35/74 (47%), Positives = 49/74 (66%) Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 PE SYT L+ G +I +KVGEE ET +AA D EL NE +DL+YH++VL D+GL Sbjct: 26 PEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNADNDELKNEINDLLYHVMVLCADRGL 85 Query: 190 DLTTVIENLRKRHQ 203 + + V E L +R++ Sbjct: 86 EWSEVEEVLSERNE 99 >UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis RepID=HIS2_SPHAL Length = 109 Score = 70.9 bits (172), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 42/102 (41%), Positives = 59/102 (57%), Gaps = 7/102 (6%) Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALA 160 S G+T L +LE ++ +R +A + E SY A L A G +IAQK+GEE VE +A Sbjct: 2 SKAMGET------LGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIA 55 Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 A D L EASDL++HL +LL ++GL + L +RH Sbjct: 56 AVSEDDPALIGEASDLVFHLSILLAERGLTWDAIAAELDRRH 97 >UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD Length = 101 Score = 70.9 bits (172), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 37/97 (38%), Positives = 54/97 (55%), Gaps = 6/97 (6%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 E + L+PV+V SG++LML Y + L+ T +G ++SR++Q +W KG +SG Sbjct: 2 ETSTKLLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQ 61 Query: 73 NVVSIAPDCDNDTL----LVLANPIGPTCHKGTSSCF 105 V ++ DCD D L LVL + G CH SCF Sbjct: 62 LVQAVYRDCDGDALNFRVLVLGD--GRVCHTRQVSCF 96 >UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales RepID=HIS2_MESSB Length = 112 Score = 70.1 bits (170), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 36/87 (41%), Positives = 57/87 (65%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L +LE ++AER ++ S+TA+L ++G + A+K+GEE VET +AA D+ L E++ Sbjct: 6 LSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKALIAESA 65 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL+YH LV+L+ G+ L V+ L R Sbjct: 66 DLVYHWLVVLKIAGVRLDEVMLELESR 92 >UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria RepID=HIS2_GRABC Length = 160 Score = 68.2 bits (165), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 37/96 (38%), Positives = 57/96 (59%), Gaps = 2/96 (2%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 D A Q L +L +++ +R+ ADP S++A+L + G ++AQK GEE VE + A D+ Sbjct: 40 DNAVQ--VLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E++D++YHLLVL G++ V L KR Sbjct: 98 EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133 >UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria RepID=HIS2_NITMU Length = 121 Score = 67.0 bits (162), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 34/88 (38%), Positives = 49/88 (55%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L++L + + RK +DP SY AKL G +I +K+ EE E LA+ D + E Sbjct: 6 ILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVVRET 65 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL +H LVLL L L V++ LR+R Sbjct: 66 ADLWFHCLVLLAHHNLKLGDVLDELRRR 93 >UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ Length = 127 Score = 65.9 bits (159), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 37/87 (42%), Positives = 52/87 (59%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L +L L+ R+S + SYTA+L +G +R A+K GEE VET +AA D L EA+ Sbjct: 24 LTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSDASALRAEAA 83 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 D +YHLLVLL+ + + V+ L R Sbjct: 84 DTLYHLLVLLESRHVAFDDVLRVLEGR 110 >UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria RepID=HIS2_NITWN Length = 116 Score = 65.1 bits (157), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 36/91 (39%), Positives = 51/91 (56%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 Q ++ L ++ R ++ + SYT KL G A+K+GEE VET +AA DR L Sbjct: 11 QRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKDRHHLI 70 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +DLM+H LVLL+ G+ L V L +R Sbjct: 71 AEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101 >UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae RepID=Q2CDY7_9RHOB Length = 106 Score = 64.7 bits (156), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 1/89 (1%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + L L + +A RK ADP+ S+TA+L AS + A+K GEE VE + A DR L +E Sbjct: 1 MSLAALAETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSE 59 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 A+D++YHLLV+ + L + L +R Sbjct: 60 AADVIYHLLVMCAVNDITLADIERELERR 88 >UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VQS9_9PROT Length = 109 Score = 64.3 bits (155), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 36/77 (46%), Positives = 44/77 (57%) Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 RK AD SYTA L G R A+K GEE VE ALA + R +L E +D++YHL VLL Sbjct: 18 RKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAETADVLYHLAVLL 77 Query: 185 QDQGLDLTTVIENLRKR 201 LD + + L KR Sbjct: 78 AANELDWSDISAALTKR 94 >UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei RepID=HIS2_IGNH4 Length = 102 Score = 64.3 bits (155), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 34/90 (37%), Positives = 54/90 (60%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 FL +L ++ +R P+ SYTA++ G A+K GEE VE +A+ R + EA Sbjct: 4 FLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYEA 63 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +D++YHL+VLL +G+D VI+ L +R + Sbjct: 64 ADVIYHLMVLLALRGVDWAEVIKELERRSR 93 >UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms RepID=HIS2_ALHEH Length = 109 Score = 64.3 bits (155), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 38/90 (42%), Positives = 52/90 (57%), Gaps = 4/90 (4%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L L ++L ER+ ADP TSY AKL+ G I +KVGEE E +AA DR ++ E Sbjct: 7 ILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVIYET 66 Query: 174 SDLMYHLLVLLQ--DQGLDLTTVIENLRKR 201 +DL +H L++L D G D V+ L +R Sbjct: 67 ADLWFHSLIMLSACDAGPD--DVLAELERR 94 >UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp. HTCC2601 RepID=Q0FX88_9RHOB Length = 164 Score = 64.3 bits (155), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 30/60 (50%), Positives = 39/60 (65%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGLMP A SGE+LMLG+M EA T+E+G+ +FSR +Q LW +G SG L +V Sbjct: 13 DGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKLV 72 >UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZNB1_9GAMM Length = 125 Score = 63.9 bits (154), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 33/88 (37%), Positives = 52/88 (59%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L L +++ +R+ ADPE SY AKL+A G + +K+GEE ET +A D L +E Sbjct: 14 LLSALAEVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKNDDSDALVSEM 73 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL +H L++L +G V++ L +R Sbjct: 74 ADLWFHSLIVLAARGRHPDDVLDELARR 101 >UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria RepID=HIS2_ACICJ Length = 133 Score = 63.5 bits (153), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 33/88 (37%), Positives = 52/88 (59%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +L + RK+ADP S++A+L + G ++AQK GEE VE + A +R L E+ Sbjct: 21 VLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNRTALIAES 80 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +D++YHLLV+ G+ V L++R Sbjct: 81 ADVLYHLLVMWVAAGVRPEDVWLELQRR 108 >UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria RepID=HIS2_CLOB1 Length = 110 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 31/83 (37%), Positives = 47/83 (56%) Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 ++ +RK E SYT L+ G +I +KVGEE E +AA D EL E DL YH+ Sbjct: 13 IIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEELIKEICDLTYHI 72 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 +VL+ ++ + L + + L KR + Sbjct: 73 MVLMVEKQIKLDDIEKELEKRRE 95 >UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria RepID=HIS2_MAGSM Length = 252 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/90 (43%), Positives = 52/90 (57%), Gaps = 2/90 (2%) Query: 114 FLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH-DRFELTN 171 L Q+ Q++ +RKSA DPE SY AKL+ G I +KVGEE E LA R E+ + Sbjct: 12 ILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKGRAARNEVAH 71 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 EA+DL++H LV L + T V+ L R Sbjct: 72 EAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101 >UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms RepID=HIS2_PELTS Length = 98 Score = 61.2 bits (147), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 34/90 (37%), Positives = 49/90 (54%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + L +++ +R+ P+ SYTA L+ G +I +K+GEE E +AA L E Sbjct: 6 IIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAALVGEM 65 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +DL+YHLLVLL GL V+ L R Q Sbjct: 66 ADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95 >UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae RepID=HIS2_NATPD Length = 101 Score = 61.2 bits (147), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 37/89 (41%), Positives = 54/89 (60%), Gaps = 2/89 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L +L +++ RK P+ SYTA L+ G + +K+GEE E LAA D EL +E Sbjct: 12 LDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDDDDEELAHE 71 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 A+D++YHLLVLL + ++L + LRKR Sbjct: 72 AADIVYHLLVLLSMKDMELADLRAELRKR 100 >UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SHA6_LEPBA Length = 202 Score = 61.2 bits (147), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 1/88 (1%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L P + Q ++G+ LML + E+L +ESG T+FSR++ W KGE SG+F + I Sbjct: 94 LSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQI 152 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF 105 + + + + IG CH G SCF Sbjct: 153 YVHSNPFFVKYITDQIGAACHTGYYSCF 180 >UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae RepID=HIS2_METBF Length = 104 Score = 61.2 bits (147), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 33/92 (35%), Positives = 53/92 (57%), Gaps = 2/92 (2%) Query: 114 FLYQLEQLLAERKSADPETSYTAKL--YASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 L ++ +++ +RK E SY KL + G +I +KVGEE +ET LA + E+ + Sbjct: 8 ILNRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNENHEEIVS 67 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E+SDL++HLLV+L + L + L RH+ Sbjct: 68 ESSDLIFHLLVMLAANNVTLDEIAAELSARHE 99 >UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM 10642 RepID=C8SBH0_FERPL Length = 92 Score = 60.8 bits (146), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 34/91 (37%), Positives = 53/91 (58%), Gaps = 2/91 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKL--YASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L +L++++ ERK SYTAKL + G ++ +K GEE VE LA D+ + E Sbjct: 2 LEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVYE 61 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 A+DL+YH +VLL + + V + LR+R + Sbjct: 62 AADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92 >UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD Length = 253 Score = 60.8 bits (146), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 30/80 (37%), Positives = 50/80 (62%) Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 ++ + +S + S+T K+ A G +I +KVGEE VE LA D + +EA+D++YH+ Sbjct: 56 IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115 Query: 181 LVLLQDQGLDLTTVIENLRK 200 L+LL GL L T+ + +R+ Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135 >UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria RepID=A6LT24_CLOB8 Length = 108 Score = 60.1 bits (144), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 32/85 (37%), Positives = 47/85 (55%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + + +RK+ E SYT L+ GT +I +KVGEE E ++ +++ E NE DL Sbjct: 8 LYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINEICDLT 67 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202 YHLLVL+ + + V L KR Sbjct: 68 YHLLVLMAQMNISIEEVGAELEKRR 92 >UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira RepID=HIS3_LEPIN Length = 187 Score = 60.1 bits (144), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 9/104 (8%) Query: 10 LDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 LD++KT L+PV+ + G++LM + N E+ +L++G +FSR++ +L Sbjct: 61 LDFQKTTELLLTGKKNLVPVVAID-LQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQL 119 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 W KG+TSG+ ++ I D L+ CH+G SCF Sbjct: 120 WKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCF 163 >UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria RepID=HIS2_HALHL Length = 114 Score = 59.7 bits (143), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 31/87 (35%), Positives = 50/87 (57%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L L + + +R+ A +TSY A+L+ G I +KVGEE E +AA +R ++ E + Sbjct: 14 LRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYETA 73 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL +H LV+L G+ + V+ L +R Sbjct: 74 DLWFHTLVMLSASGVSVDEVLAELERR 100 >UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing symbionts RepID=HIS2_VESOH Length = 105 Score = 59.3 bits (142), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 31/88 (35%), Positives = 49/88 (55%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +LEQ+L +RKSA + SY + LY GT I +K+ EE E +A ++ E Sbjct: 4 ILIKLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEI 63 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL +H LVLL+ + + + + L +R Sbjct: 64 ADLWFHTLVLLRFKKIKVEQITNELSRR 91 >UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota RepID=HIS2_META3 Length = 96 Score = 58.9 bits (141), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 31/74 (41%), Positives = 46/74 (62%), Gaps = 4/74 (5%) Query: 120 QLLAERKSADPETSYTAKLYASGTK----RIAQKVGEEGVETALAATVHDRFELTNEASD 175 +++ +R PE SY A L + K +I +KVGEE ET LAA D+ EL E++D Sbjct: 9 EIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESAD 68 Query: 176 LMYHLLVLLQDQGL 189 L++H+LVLL + G+ Sbjct: 69 LIFHILVLLANNGI 82 >UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria RepID=HIS2_NEIG1 Length = 107 Score = 58.2 bits (139), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 32/88 (36%), Positives = 48/88 (54%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L ++Q + +RKSADP SY A+L G +I +KV EE E +A+ D L E Sbjct: 5 VLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHLVYEV 64 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL +H ++LL L V++ L +R Sbjct: 65 ADLWFHTMILLTHHDLKAEDVLDELSRR 92 >UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SQK1_VERA1 Length = 699 Score = 58.2 bits (139), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 8/119 (6%) Query: 80 DCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLY 139 DCDND + + G CH CFG+ + +LE+ L RK + PE SYTA+L+ Sbjct: 173 DCDNDAIKFVVRQKGRFCHLEQDGCFGNLTG----IARLEKTLKARKESAPEGSYTARLF 228 Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198 + K + K+ EE E A T D + EA+DL+Y L G+ + + ++L Sbjct: 229 -NDEKLLRAKIMEEAEELCDAKTKED---VAFEAADLIYFALTKAVSAGVSVADIEKSL 283 >UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes RepID=HIS2_BACC2 Length = 107 Score = 58.2 bits (139), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 28/85 (32%), Positives = 49/85 (57%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + + ERK + SYT L++ G +I +K+GEE E +A +D+ E+ E D+ Sbjct: 8 LYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVF 67 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202 YH VLL ++ + L V+ +++R+ Sbjct: 68 YHCFVLLAEKNIALEDVMREVKERN 92 >UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium RepID=HIS2_CLONN Length = 110 Score = 57.8 bits (138), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 29/90 (32%), Positives = 51/90 (56%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + +L ++ +RK E SYT L+ G +I +KVGEE E +AA ++ +L E Sbjct: 6 VIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDDLIAEV 65 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 D++YH++VL+ ++ + L + L KR + Sbjct: 66 CDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95 >UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales RepID=Q0F926_9RHOB Length = 105 Score = 57.4 bits (137), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 33/89 (37%), Positives = 56/89 (62%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +L Q + RK+ E SY ++L SG+++ A+K GEE VE +AA D+ LT E+ Sbjct: 4 ILIRLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEES 63 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +D+++H+LV+L +D +V++ L +R Sbjct: 64 ADVLFHMLVMLSSCDVDFKSVLKELERRE 92 >UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales RepID=HIS2_LEUMM Length = 114 Score = 56.2 bits (134), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 33/78 (42%), Positives = 45/78 (57%), Gaps = 1/78 (1%) Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 ERK SYT LY G +I +KVGEE E L A ++ EL E SDL++HL+VL Sbjct: 15 ERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNNE-ELIYETSDLLFHLMVL 73 Query: 184 LQDQGLDLTTVIENLRKR 201 L ++G+ L + + L R Sbjct: 74 LVEKGVSLDDIKDELGSR 91 >UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5 Length = 105 Score = 55.8 bits (133), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 29/87 (33%), Positives = 50/87 (57%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +L ++ +RK + SYT L+ G +I +KVGEE E +A+ ++ + E DL Sbjct: 4 ELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEICDL 63 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +YH+LVL+ ++ + L + + L KR Q Sbjct: 64 IYHVLVLMANENITLEELRKELEKRRQ 90 >UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SM22_9BACT Length = 100 Score = 54.7 bits (130), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 28/88 (31%), Positives = 51/88 (57%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + +L +++ ERK+ + SYT +L G+ +I +K+GEE E A D ++ E Sbjct: 5 IIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDVAGET 64 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL+YHL+V L+ + + V+ L++R Sbjct: 65 ADLLYHLIVALEFRNVQFEDVLGVLQER 92 >UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales RepID=HIS2_METB6 Length = 104 Score = 53.9 bits (128), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 32/91 (35%), Positives = 49/91 (53%), Gaps = 2/91 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + +L ++ ER E SYT++L G ++ +KVGEE E LA T E Sbjct: 14 IRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEESTEFILAVKNGVPERTTEE 73 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 A+DL +H+LV L+ +DL+ VI L +R + Sbjct: 74 AADLFFHVLVALRAADVDLSGVIRELERRRK 104 >UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TJZ9_9PROT Length = 104 Score = 53.5 bits (127), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 29/78 (37%), Positives = 45/78 (57%) Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185 ++ P S TA+L G +IA+KV EE E AL A V DR + E++DL+Y+L+VL Sbjct: 16 RAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRESADLLYNLMVLWV 75 Query: 186 DQGLDLTTVIENLRKRHQ 203 G+ + V + +R + Sbjct: 76 WMGITPSEVWAEMEQREK 93 >UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae RepID=HIS2_METS5 Length = 93 Score = 52.8 bits (125), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 38/90 (42%), Positives = 55/90 (61%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +L ++A+R PE SYTA L G +A+KVGEE VE +A+ R + +E Sbjct: 4 VLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSET 63 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +DL+YHLLVLL +G+ L V + LR+R + Sbjct: 64 ADLIYHLLVLLAMEGISLDEVRDELRRRMK 93 >UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria RepID=HIS2_BURCC Length = 121 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 4/91 (4%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR----FELT 170 L +L ++ RK DP+ SY ++L+ G + +K+GEE E LAA + L Sbjct: 9 LLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQGGAPTALV 68 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +DL +H LV+L L VI L +R Sbjct: 69 GEVADLWFHCLVMLSHFDLSPADVIAELERR 99 >UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae RepID=Q0C645_HYPNA Length = 120 Score = 51.6 bits (122), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/74 (39%), Positives = 40/74 (54%) Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 D +S+TAKL A G A KV EEG E A A + +EA+D++YH+ V L+ +G Sbjct: 32 DASSSWTAKLLAKGPDAAAAKVAEEGGELADAVRRESDDRVASEAADVIYHVFVALRSRG 91 Query: 189 LDLTTVIENLRKRH 202 + L V L R Sbjct: 92 VALDAVAGALEARQ 105 >UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic archaeon RC-I RepID=HIS2_UNCMA Length = 95 Score = 51.2 bits (121), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 2/91 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L ++ ++A+RK E SYT LY G ++ +K+GEE E +AA E+ +E Sbjct: 5 LDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIVSE 64 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +DL +H +VLL + + + E +R + Sbjct: 65 CADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95 >UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ9_9ACTN Length = 105 Score = 51.2 bits (121), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/87 (34%), Positives = 46/87 (52%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L L +++ R+ A P+ SYTA+L + +K+ EE E +A +D + EA Sbjct: 17 LTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIMACKDNDHDHIRYEAG 76 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL+YHLLV L+ G+ L + L R Sbjct: 77 DLVYHLLVTLERYGITLDELAGELNAR 103 >UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei group RepID=HIS2_LACCB Length = 110 Score = 51.2 bits (121), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/85 (34%), Positives = 44/85 (51%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + ER++ SYT L+ G +I +KVGEE E +AA D E +DL Sbjct: 11 LYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPAFILEVADLT 70 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202 YH+LVL+ ++G+ + + L R Sbjct: 71 YHVLVLMVERGITVDQIATELASRE 95 >UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium RepID=C4L178_EXISA Length = 102 Score = 50.8 bits (120), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/89 (43%), Positives = 55/89 (61%), Gaps = 2/89 (2%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 +++LEQL+ RK E SYT L+ G ++IA+K GEE E +AA + +L E+ Sbjct: 1 MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTDE--DLVEES 58 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL+YHLLVLL +G+ L V L KRH Sbjct: 59 ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87 >UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FUB9_METHJ Length = 91 Score = 50.4 bits (119), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 25/83 (30%), Positives = 49/83 (59%), Gaps = 2/83 (2%) Query: 121 LLAERKSADPETSYTAKL--YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 ++ ER + E SYT+K+ ++ G + +K+GEE E +A D+ ++ E +DL++ Sbjct: 7 VIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEEGADLLF 66 Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201 H ++ L+ G+ L +V + L+ R Sbjct: 67 HFMLALKRSGVTLQSVWDELQSR 89 >UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales RepID=HIS2_BORA1 Length = 116 Score = 50.4 bits (119), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 28/74 (37%), Positives = 38/74 (51%) Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 DP+TSY AKL A G +K+GEE E +AA + +E +DL +H LV L Sbjct: 29 DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88 Query: 189 LDLTTVIENLRKRH 202 L V+ L +R Sbjct: 89 LRPEDVLAELARRE 102 >UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae RepID=HIS22_BRAJA Length = 134 Score = 49.7 bits (117), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 41/74 (55%) Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 DP TS TA+L+ G ++A+K+ EE +E + A D + E++DL+Y+L VL G Sbjct: 19 DPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRESADLLYNLTVLWASAG 78 Query: 189 LDLTTVIENLRKRH 202 + V + +R Sbjct: 79 VRPEDVWREMTRRE 92 >UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani RepID=HIS2_CLOTE Length = 107 Score = 49.7 bits (117), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 4/88 (4%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + +L +++ +RK+ D SY L+ + +I +K+GE+ E +A + E +E Sbjct: 6 LIEELVEVIKDRKN-DIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEI 61 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 SDL+Y+L+VL+ Q +++ VIE L KR Sbjct: 62 SDLIYNLMVLMMKQNIEIENVIEELGKR 89 >UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae RepID=A4SV22_POLSQ Length = 133 Score = 49.7 bits (117), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%) Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAA--------TVHDRFELTNEASDLMY 178 SADP+TSYTA L++ G I +K+GEE E +AA + L E +DL + Sbjct: 33 SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92 Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201 H L+ L L VI L +R Sbjct: 93 HCLIALSQFNLRPEDVIAELDRR 115 >UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria RepID=HIS2_ACIAC Length = 137 Score = 47.4 bits (111), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 33/111 (29%), Positives = 48/111 (43%), Gaps = 7/111 (6%) Query: 98 HKGTSSCFGDTAHQWLFLYQLEQLLAERKSA---DPETSYTAKLYASGTKRIAQKVGEEG 154 H S H L +L ++ RK A D + SY A+L G +K+GEE Sbjct: 3 HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62 Query: 155 VETALAAT----VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +AA D +L E +DL +H ++ L GL V+ L +R Sbjct: 63 TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERR 113 >UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria RepID=HIS2_METS4 Length = 107 Score = 47.0 bits (110), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 40/87 (45%), Positives = 59/87 (67%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L L++++ R +A P+ SYTAKL A+G + A+K+GEE VE A+AA DR L +EA+ Sbjct: 6 LADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGLVSEAA 65 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 D++YHLLV+L G+ L V+ L +R Sbjct: 66 DVLYHLLVVLVGSGVALEDVMAELERR 92 >UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB Length = 101 Score = 45.8 bits (107), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 2/89 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L L + +RK+ D + SYT+ L + G + K+ EE E L ++D+ + +EA+ Sbjct: 5 LLNLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDE--LKEALNDKSNIVHEAA 62 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 D +YH+LV L+ + V++ L R + Sbjct: 63 DTIYHILVTLEAADIKFEDVLKELEGRKK 91 >UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K RepID=B4UDK1_ANASK Length = 110 Score = 45.1 bits (105), Expect = 0.001, Method: Compositional matrix adjust. Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 7/95 (7%) Query: 114 FLYQLEQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVET-----ALAATVHDRF 167 FL +L + R++ A P SYT KL A+ RI +K+ EE E AL + Sbjct: 6 FLAKLWATIESRRADAAPAESYTKKLLAAPA-RIRRKIIEEAYEVNEAHQALLDGKDTKD 64 Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L +EA+DL+YHL VLL + T V L +RH Sbjct: 65 HLAHEAADLLYHLYVLLASADVTPTEVYGVLERRH 99 >UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQN9_9RICK Length = 103 Score = 44.7 bits (104), Expect = 0.002, Method: Compositional matrix adjust. Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 3/80 (3%) Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 + ERK++ SYT KL + + +KV EE E L ++++ +EA+D+MYH+L Sbjct: 12 IRERKNSSEHESYTKKLLDNNS-LCREKVMEEIKE--LVEALNEKKNEVHEAADVMYHIL 68 Query: 182 VLLQDQGLDLTTVIENLRKR 201 VLL+ + + V+ L+KR Sbjct: 69 VLLEANNVKVEDVMNELKKR 88 >UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae RepID=HIS2_METS3 Length = 96 Score = 43.9 bits (102), Expect = 0.003, Method: Compositional matrix adjust. Identities = 30/94 (31%), Positives = 53/94 (56%), Gaps = 8/94 (8%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKR----IAQKVGEEGVETALAATVHDRFEL 169 + ++ ++L ER+ +P SYT+K+ K+ I +KV EE E LAA + L Sbjct: 6 IIREVYKVLEERRD-NPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKNDEN--L 62 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENL-RKRH 202 E+ DL++H L++L +G+++ + E R+RH Sbjct: 63 VYESVDLIFHTLLILVYKGIEIDEIFEEFARRRH 96 >UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RQ70_FIBSS Length = 86 Score = 42.7 bits (99), Expect = 0.007, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 42/82 (51%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 ++ L +RK PE T +L+ G I +K+ EE E+ +AA R E S + Sbjct: 5 EMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLELSQV 64 Query: 177 MYHLLVLLQDQGLDLTTVIENL 198 +Y++ V++ ++GL L V L Sbjct: 65 LYYVAVMMAEKGLTLEEVYAKL 86 >UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae RepID=HIS2_RHOBA Length = 120 Score = 42.0 bits (97), Expect = 0.011, Method: Compositional matrix adjust. Identities = 35/92 (38%), Positives = 47/92 (51%), Gaps = 3/92 (3%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFEL 169 L L +L L R + PE SYT KL G + I +K+ EE E AA D R Sbjct: 6 LPLDRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHA 65 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 EA DL+YH +VL+ +G++L V L +R Sbjct: 66 IYEAGDLIYHAMVLMAWRGIELDEVAAELARR 97 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ... 283 3e-75 UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero... 280 3e-74 UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri... 277 2e-73 UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac... 276 2e-73 UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri... 276 4e-73 UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon... 270 1e-71 UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter... 270 2e-71 UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell... 270 3e-71 UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob... 269 3e-71 UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 268 1e-70 UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI... 267 1e-70 UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba... 266 3e-70 UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm... 265 5e-70 UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac... 265 8e-70 UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi... 264 1e-69 UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact... 262 7e-69 UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 261 9e-69 UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p... 261 1e-68 UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific... 258 9e-68 UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana... 257 2e-67 UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy... 256 3e-67 UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell... 255 7e-67 UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul... 255 8e-67 UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm... 253 2e-66 UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl... 252 6e-66 UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy... 252 7e-66 UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 252 7e-66 UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl... 251 1e-65 UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 250 2e-65 UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos... 250 2e-65 UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote... 247 1e-64 UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 247 1e-64 UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy... 246 4e-64 UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu... 245 6e-64 UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor... 245 6e-64 UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ... 245 9e-64 UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman... 244 1e-63 UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos... 242 4e-63 UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy... 241 9e-63 UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero... 241 1e-62 UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI... 241 1e-62 UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI... 240 2e-62 UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His... 240 3e-62 UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ... 239 4e-62 UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte... 238 1e-61 UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu... 236 4e-61 UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep... 235 1e-60 UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His... 233 3e-60 UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 233 4e-60 UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy... 231 1e-59 UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5 229 4e-59 UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 229 5e-59 UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 223 3e-57 UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A... 213 2e-54 UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper... 211 1e-53 UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI... 210 2e-53 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 209 4e-53 UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ... 206 4e-52 UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom... 194 1e-48 UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T... 193 4e-48 UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1... 192 6e-48 UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros... 188 1e-46 UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor... 186 3e-46 UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz... 186 3e-46 UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo... 184 2e-45 UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon... 173 3e-42 UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu... 173 5e-42 UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu... 170 2e-41 UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter... 167 2e-40 UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter... 166 3e-40 UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul... 166 4e-40 UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu... 166 5e-40 UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax... 166 6e-40 UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin... 164 1e-39 UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar... 164 1e-39 UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo... 164 2e-39 UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote... 164 2e-39 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 164 2e-39 UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin... 163 3e-39 UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap... 163 3e-39 UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 163 3e-39 UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte... 163 4e-39 UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T... 163 4e-39 UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 162 5e-39 UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell... 162 6e-39 UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy... 161 1e-38 UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote... 161 1e-38 UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote... 161 1e-38 UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte... 161 2e-38 UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin... 161 2e-38 UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch... 161 2e-38 UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap... 160 2e-38 UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte... 160 3e-38 UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul... 159 4e-38 UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein... 159 5e-38 UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte... 159 5e-38 UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap... 159 6e-38 UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm... 159 6e-38 UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte... 159 6e-38 UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte... 159 7e-38 UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul... 158 8e-38 UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 157 2e-37 UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact... 157 2e-37 UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob... 157 2e-37 UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax... 157 2e-37 UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu... 157 2e-37 UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon... 156 3e-37 UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero... 156 5e-37 UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan... 156 5e-37 UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote... 155 7e-37 UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte... 153 3e-36 UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote... 153 4e-36 UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu... 152 6e-36 UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob... 152 6e-36 UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin... 152 9e-36 UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein... 151 1e-35 UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob... 151 1e-35 UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing... 150 2e-35 UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo... 150 3e-35 UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero... 150 3e-35 UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap... 150 3e-35 UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p... 150 3e-35 UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom... 149 4e-35 UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob... 149 6e-35 UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro... 149 7e-35 UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo... 148 8e-35 UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=... 148 9e-35 UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ... 148 2e-34 UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu... 147 2e-34 UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr... 145 7e-34 UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl... 144 1e-33 UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing... 143 3e-33 UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr... 141 2e-32 UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax... 141 2e-32 UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo... 140 3e-32 UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo... 138 1e-31 UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros... 134 2e-30 UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico... 133 3e-30 UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing... 132 9e-30 UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha... 131 1e-29 UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos... 129 5e-29 UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1... 129 7e-29 UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu... 128 9e-29 UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact... 126 4e-28 UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact... 126 7e-28 UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C... 124 1e-27 UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost... 124 2e-27 UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo... 124 2e-27 UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm... 123 3e-27 UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=... 123 3e-27 UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos... 123 3e-27 UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph... 121 1e-26 UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap... 121 1e-26 UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi... 120 2e-26 UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha... 120 2e-26 UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk... 120 3e-26 UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph... 120 4e-26 UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo... 119 5e-26 UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri... 118 1e-25 UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot... 118 1e-25 UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell... 118 1e-25 UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl... 118 1e-25 UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto... 118 1e-25 UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T... 118 2e-25 UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot... 117 2e-25 UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul... 117 3e-25 UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid... 116 5e-25 UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote... 116 6e-25 UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha... 115 8e-25 UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther... 115 9e-25 UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh... 114 2e-24 UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta... 114 2e-24 UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph... 114 2e-24 UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha... 114 2e-24 UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 114 2e-24 UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot... 114 2e-24 UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto... 113 4e-24 UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra... 112 7e-24 UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom... 111 1e-23 UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph... 111 2e-23 UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob... 111 2e-23 UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo... 111 2e-23 UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi... 110 2e-23 UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu... 110 4e-23 UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor... 109 4e-23 UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins... 108 9e-23 UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha... 108 9e-23 UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=... 107 2e-22 UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=... 105 9e-22 UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin... 104 2e-21 UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br... 104 2e-21 UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 104 2e-21 UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury... 102 8e-21 UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu... 102 1e-20 UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost... 100 3e-20 UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom... 96 4e-19 UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov... 95 1e-18 UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re... 95 2e-18 UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob... 91 2e-17 UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo... 91 2e-17 UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta... 91 3e-17 UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo... 90 4e-17 UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo... 85 1e-15 UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph... 72 1e-11 Sequences not found previously or not previously below threshold: UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha... 87 4e-16 UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p... 85 1e-15 UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc... 85 1e-15 UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus... 84 2e-15 UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth... 78 2e-13 UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 78 2e-13 UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre... 77 3e-13 UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti... 77 5e-13 UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact... 71 2e-11 UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba... 71 2e-11 UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac... 66 5e-10 UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase... 62 1e-08 UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax... 59 7e-08 UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 59 1e-07 UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas... 58 2e-07 UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm... 54 2e-06 UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax... 53 8e-06 UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID... 49 1e-04 UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip... 48 1e-04 UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax... 46 6e-04 UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp.... 45 0.001 UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog... 44 0.003 UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma... 43 0.006 UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Glucona... 43 0.006 UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact... 43 0.008 UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1... 43 0.009 UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R... 42 0.012 UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ... 42 0.013 UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY... 42 0.013 UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferro... 41 0.023 UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC... 41 0.024 UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax... 41 0.024 UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm... 41 0.024 UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID... 41 0.025 UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str... 41 0.026 UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber D... 41 0.027 UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ... 41 0.028 UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus... 41 0.030 UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip... 41 0.033 UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil... 41 0.035 UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=... 41 0.036 UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB... 41 0.037 UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG fami... 40 0.039 UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus... 40 0.060 UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus k... 40 0.060 UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermo... 39 0.072 >UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT Length = 215 Score = 283 bits (724), Expect = 3e-75, Method: Composition-based stats. Identities = 98/196 (50%), Positives = 135/196 (68%), Gaps = 2/196 (1%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++D++K GL+P ++Q + VLMLGYMN EA KT+E+ KVTF+SR++ LWTKGETS Sbjct: 2 QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126 GN+L++VSI DCDNDTLLV +P GPTCH GT +C+G+T + LFL +L+ + R Sbjct: 62 GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 P+ SYT L+ G ++IAQKVGEE VET + A + L EASD++YHL+VLL Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181 Query: 187 QGLDLTTVIENLRKRH 202 +GL + + L +RH Sbjct: 182 KGLHIEDLARELARRH 197 >UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4Y5_SPHTD Length = 228 Score = 280 bits (716), Expect = 3e-74, Method: Composition-based stats. Identities = 86/195 (44%), Positives = 118/195 (60%), Gaps = 9/195 (4%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGETSGN VV Sbjct: 23 GLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGETSGNVHEVVE 82 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQLEQLLAERKS 127 I PDCD D LLV P GPTCH GT +CF + ++ +++AER++ Sbjct: 83 IRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDEVARVVAERRA 142 Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187 E SYT L +G +I +K+GEE E +AA D L NEA+DL+YHLLVLL+ Sbjct: 143 HPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLIYHLLVLLEAS 202 Query: 188 GLDLTTVIENLRKRH 202 + V LR R Sbjct: 203 DVPTERVWAVLRTRR 217 >UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria RepID=C6J1M1_9BACL Length = 231 Score = 277 bits (708), Expect = 2e-73, Method: Composition-based stats. Identities = 93/213 (43%), Positives = 129/213 (60%), Gaps = 13/213 (6%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 E + + W+ GL+P IVQ A S EVLML YMN E+L K++E+G+ F+SR++ LW Sbjct: 15 IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA------------H 110 KG TSGN + ++ DCD DTLLV GP CH G +CF TA Sbjct: 74 NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133 Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 ++ L +LEQL+AER + PE +YT L+ G +I +KVGEE E+ +AA D EL Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E SDL+YHLLVLL+++ L L +++ L +RH+ Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226 >UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria RepID=HIS2_VIBVY Length = 211 Score = 276 bits (707), Expect = 2e-73, Method: Composition-based stats. Identities = 129/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 ++WEK DGL+P IVQ S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL Sbjct: 7 EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG---DTAHQWLFLYQL 118 WTKGETSGN L +V+++ DCDNDTLLV NPIGPTCH GT++C+ Q ++L+QL Sbjct: 67 WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT D+ EL E++DL+Y Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 HLLVLLQDQGL + VI L++RH+ Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211 >UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria RepID=C6PCK8_CLOTS Length = 228 Score = 276 bits (706), Expect = 4e-73, Method: Composition-based stats. Identities = 80/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 +L ++ GL+P IVQ + EVLM+ YMN E+L+K+LE+ + FFSR++Q LW KG Sbjct: 8 NIDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKG 66 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------DTAHQWLFLYQ 117 ETSGN ++ +I DCD DTLLV P GP CH G +SCF + + L Sbjct: 67 ETSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSN 126 Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + + RK SYT L+ G +I +K+GEE E +A+ + E+ E +D + Sbjct: 127 LYRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYI 186 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 YHL+VL+ ++G++L V + + KR Sbjct: 187 YHLMVLMVEKGINLNDVYKEISKR 210 >UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae RepID=C4V2J2_9FIRM Length = 235 Score = 270 bits (692), Expect = 1e-71, Method: Composition-based stats. Identities = 77/204 (37%), Positives = 112/204 (54%), Gaps = 19/204 (9%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ + +VLML YMN E+L+KT+E+G ++SR++Q+LW KGETSGN + Sbjct: 15 GLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQKLWKKGETSGNVQRIKE 73 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFG------------------DTAHQWLFLYQL 118 I+ DCD DT+L+ G CH GT SCF + L L Sbjct: 74 ISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIPLIEKEEHPLTEVLASL 133 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 Q++ R+ E SYT L+ G +I +K+GEE ET +A+ + R ++ E DL Y Sbjct: 134 YQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASKNNIREDVLYEMGDLWY 193 Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202 H LVLL + ++E L++R+ Sbjct: 194 HCLVLLAYHNMTPEDLLEELKRRN 217 >UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria RepID=A9B1U1_HERA2 Length = 212 Score = 270 bits (691), Expect = 2e-71, Method: Composition-based stats. Identities = 104/203 (51%), Positives = 130/203 (64%), Gaps = 10/203 (4%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 EL ++ + GL+P +VQHA SGEVLM+GYMN EAL KT SG VTF+SR++Q+LWTKGETS Sbjct: 3 ELTYD-SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH---------QWLFLYQLE 119 GN L ++ DCDND LL+LA P GPTCH G+ SCF T F+ QL Sbjct: 62 GNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLF 121 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 + L ER+ P SYT L G +I +K+GEE E +AA + EL NEASDL+YH Sbjct: 122 EFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYH 181 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 L VLL +QG+ V LR+RH Sbjct: 182 LFVLLLNQGVSPEDVWFTLRERH 204 >UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms RepID=HIS2_SYNPX Length = 222 Score = 270 bits (690), Expect = 3e-71, Method: Composition-based stats. Identities = 71/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L+ +L + + GL+P I Q + G VLM+ +MN E++ +TL SG+ ++SR++Q L Sbjct: 4 LSPAFIDQLRFNEA-GLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTA----------- 109 W KG TSG+ + SI DCD D LL+ G CH G SCF + Sbjct: 63 WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122 Query: 110 -HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 +L +++ R+ E SYT KL G +I +K+GEE E +A + E Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + EA+D+++H+ V L G+ V E L R Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216 >UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria RepID=B5EQF3_ACIF5 Length = 230 Score = 269 bits (689), Expect = 3e-71, Method: Composition-based stats. Identities = 82/204 (40%), Positives = 114/204 (55%), Gaps = 12/204 (5%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + W DGL+P I Q A SG VLML +MN +AL TL G T++SR++Q LW KGETSG Sbjct: 15 VRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRKGETSG 73 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-----------DTAHQWLFLYQL 118 + ++V + DCD DTLL+ GP CH G +CF L L Sbjct: 74 HIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGSILDSL 133 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 + L R++ADP SY A+L G RI +KVGEE E +A H+ + EA+DL++ Sbjct: 134 QVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEAADLVF 193 Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202 HL+V L+++ L + V+ L +R Sbjct: 194 HLMVALEERDLHIDDVLGELARRE 217 >UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Legionella RepID=C6N0X1_9GAMM Length = 207 Score = 268 bits (685), Expect = 1e-70, Method: Composition-based stats. Identities = 95/195 (48%), Positives = 131/195 (67%), Gaps = 1/195 (0%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LDW+K +GL+P I+Q+A +G VLMLGYMN EAL T+ +G++T +SR+++RLW KGETSG Sbjct: 9 LDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGETSG 68 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLEQLLAERKSA 128 N + V I+ DCD+D+LL++ P GP CH G +SC+ H F+ L +++ ER Sbjct: 69 NTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINERAET 128 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 E SYTA+L ASG R AQKVGEE VET +AA E NE +DL++HLLVLL+ Sbjct: 129 QAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLKASE 188 Query: 189 LDLTTVIENLRKRHQ 203 L V++ L+ R + Sbjct: 189 LSFYDVLQCLQDRDR 203 >UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria RepID=Q2JWX9_SYNJA Length = 231 Score = 267 bits (684), Expect = 1e-70, Method: Composition-based stats. Identities = 79/198 (39%), Positives = 108/198 (54%), Gaps = 9/198 (4%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P IVQ + G VLM+ +MN E+L KTLE+G+ F+SR++Q LW KGETSG+ Sbjct: 31 NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQW 90 Query: 74 VVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAE 124 V I DCD+D L++L +G CH G SCF GD L Q+ ++ Sbjct: 91 VKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKA 150 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R++ SYT+ L A G I +K+GEE E +AA D+ L E +DL YH LV L Sbjct: 151 RQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVAL 210 Query: 185 QDQGLDLTTVIENLRKRH 202 +D+ V L+ R Sbjct: 211 AHHQVDIRDVYRQLQARR 228 >UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae RepID=C5SM65_9CAUL Length = 215 Score = 266 bits (681), Expect = 3e-70, Method: Composition-based stats. Identities = 111/202 (54%), Positives = 137/202 (67%), Gaps = 1/202 (0%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 LT LD+ K DGL+P IVQ A + +VLMLGYM+ AL +TL +VTFFSR+K Sbjct: 11 LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-DTAHQWLFLYQLEQ 120 W KGETSG+FLN+VS+ DCD D LLVLA P+GPTCH T+SCFG DTA F+ L Sbjct: 71 WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130 Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 ++ +R A P SYTA+L G +IAQKVGEEG+ETALA D EL NEA+DL+YHL Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190 Query: 181 LVLLQDQGLDLTTVIENLRKRH 202 VLL + L V++ LR+RH Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212 >UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes RepID=HIS2_OCEIH Length = 215 Score = 265 bits (679), Expect = 5e-70, Method: Composition-based stats. Identities = 82/191 (42%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P IVQ SG+VL L YMN +++ KT+E+ + F+SR +Q LW KG TSGN V Sbjct: 16 GLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQELWNKGATSGNKQTVKQ 75 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LYQLEQLLAERKSADPE 131 I+ DCD D +LVL + GP CH G SCF + ++ + Q+ + ER E Sbjct: 76 ISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQIIPQVSAKIKERHEHPVE 135 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 +YT+ L+ G +I +K+GEE E +AA D+ ELT+E SDL+YH LVL++ QG+ L Sbjct: 136 GAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSDLLYHSLVLMEQQGVTL 195 Query: 192 TTVIENLRKRH 202 + + L KRH Sbjct: 196 EDIKKELYKRH 206 >UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria RepID=HIS2_BLOFL Length = 213 Score = 265 bits (677), Expect = 8e-70, Method: Composition-based stats. Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT ++ + L+W K GL+P I+QH++SGEVLMLGYMN E++ T ++G VTFFSR+K R Sbjct: 1 MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KGE+SGN L +++ PDCD D+LL+L P G TCHK T+SCF + FL+QLE Sbjct: 61 LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120 Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 +++ +K+ + ++SYT+ LY SG +RIAQKVGEEG+ETALAA + L +EASD Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L+YHLLVLLQ + L+ VI+ LR R + Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208 >UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3 Tax=Clostridiales RepID=C4Z9Z2_EUBR3 Length = 427 Score = 264 bits (675), Expect = 1e-69, Method: Composition-based stats. Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%) Query: 1 MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56 +L + +L W +DG++PVIVQ + +VLML YMN EA + T+ SG++T++SR Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274 Query: 57 TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108 ++ LWTKG TSG+ V S+ DCD DT+L + +G CH +CF + Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334 Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + L + ++ +R E SYT + G I +K+G E E LAA D + Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 L E SD MYH ++L+ + + + L +R Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427 >UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria RepID=HIS2_XANCP Length = 206 Score = 262 bits (669), Expect = 7e-69, Method: Composition-based stats. Identities = 115/197 (58%), Positives = 135/197 (68%), Gaps = 2/197 (1%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 LDW K DGL+PVIVQ A + VLMLGYMN EAL T G+VTFFSR+KQRLWTKGE Sbjct: 12 LDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGE 71 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 +SGN L VV+I DCD DTLLV A P GPTCH G +SCF FL L+ L+AER+ Sbjct: 72 SSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCF--PTAPSQFLGSLDALIAERE 129 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 P SYT KL+ G +RIAQKVGEEGVETALA V EL E++DL+YHL+VLL+ Sbjct: 130 HERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRA 189 Query: 187 QGLDLTTVIENLRKRHQ 203 +GL L + L RH+ Sbjct: 190 RGLGLGDAVALLESRHK 206 >UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=10 Tax=Bacteria RepID=C0QVS5_BRAHW Length = 220 Score = 261 bits (668), Expect = 9e-69, Method: Composition-based stats. Identities = 77/203 (37%), Positives = 116/203 (57%), Gaps = 6/203 (2%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + + +L ++ GL+P IV + EVL L YMN E+L+ +++ K F+SR++Q LW Sbjct: 6 QNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQELWR 64 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQL 118 KGETSGN+ ++ SI DCDND L++ GP CH G+ SCF + ++ + +L Sbjct: 65 KGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSIDKL 124 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 +L+ RK E SYT L+ SG +I +KVGEE E + A E E SDL+Y Sbjct: 125 YKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDLLY 184 Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201 H LVL+ ++G+ + + L R Sbjct: 185 HSLVLMVEKGITINDIKNELASR 207 >UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1 Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL Length = 207 Score = 261 bits (668), Expect = 1e-68, Method: Composition-based stats. Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 1/195 (0%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 +D+EK +GL+PV+VQ A + +VL L YM+ ALD+T++SG+ TFFSR++ W KGETSG Sbjct: 7 IDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGETSG 66 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-FLYQLEQLLAERKSA 128 + L+VV I DCD+D L++ NP+G CH +SCFG L + +LEQ +AER +A Sbjct: 67 DRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERAAA 126 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 DP S+TAKL G KRIAQKVGEEGVETALA EL +EA+DL+YHLLVLL + Sbjct: 127 DPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHARN 186 Query: 189 LDLTTVIENLRKRHQ 203 + V++ L R + Sbjct: 187 MVFQDVLDVLASRAE 201 >UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae RepID=B4U8T9_HYDS0 Length = 207 Score = 258 bits (660), Expect = 9e-68, Method: Composition-based stats. Identities = 81/205 (39%), Positives = 118/205 (57%), Gaps = 9/205 (4%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ ++ GL+PVI Q A SGE+ ML Y N EA+ KT+E+G +FSR++ +W KGE Sbjct: 3 IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCF---GDTAHQWLFLYQ----L 118 TSG V+ I DCDNDTL+ + CH G +CF D L ++ L Sbjct: 62 TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 E+L+ +R S E+SYT+KL G RI QKVGEE +E+ +A D+ E+ E +DL+Y Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 H+LV ++ + V L +RH+ Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206 >UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ Length = 211 Score = 257 bits (657), Expect = 2e-67, Method: Composition-based stats. Identities = 89/201 (44%), Positives = 118/201 (58%), Gaps = 14/201 (6%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V Sbjct: 8 DGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVT 67 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------GDTAHQWLFLYQLEQL 121 S+ DCD DTLL L P GP CH G +SCF D L L QL Sbjct: 68 SLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQL 127 Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 + +R P+ SY KL G ++ +KVGEE E A D+ E+ +E++DL++H L Sbjct: 128 IEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHTL 187 Query: 182 VLLQDQGLDLTTVIENLRKRH 202 + L+ +DL+ V++ L RH Sbjct: 188 LALKYFQVDLSEVLQELHNRH 208 >UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI Length = 244 Score = 256 bits (655), Expect = 3e-67, Method: Composition-based stats. Identities = 85/218 (38%), Positives = 115/218 (52%), Gaps = 27/218 (12%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + W+ GL+P I Q ++S EVLML YMN EAL+ TL++G +FSR+KQR+W KGE SG Sbjct: 6 IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------------- 106 N V I DCD+D++L+ N G CH G SCF Sbjct: 65 NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124 Query: 107 ---DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163 + + + L L L ERK+AD TSYTA L+A GT IA+K+ EE E A Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 D E+ E +D+ YH+LV L + + + + L KR Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222 >UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms RepID=HIS2_THEP3 Length = 216 Score = 255 bits (652), Expect = 7e-67, Method: Composition-based stats. Identities = 80/215 (37%), Positives = 115/215 (53%), Gaps = 22/215 (10%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 E +EL ++ GL+PVI Q + EVLM+ Y+ L K+LE+GKV +FSR++ +LW Sbjct: 2 ENILKELKFDDR-GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107 KGETSG+F + SI+ DCD DTLL+ + CH G SCF Sbjct: 61 KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120 Query: 108 -----TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162 A L ++ ++ +R E SYT L+ G +I +KVGEE E + A Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180 Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197 D+ E+ E SDL+YHLLVL+ ++G+ L + E Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215 >UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms RepID=C9RV77_GEOSY Length = 216 Score = 255 bits (651), Expect = 8e-67, Method: Composition-based stats. Identities = 97/203 (47%), Positives = 128/203 (63%), Gaps = 10/203 (4%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++ ++ GL+P IVQ A S EVL L YMN E+L+KTLE+G+ F+SR++Q LW KG TS Sbjct: 4 DIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGATS 62 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------TAHQWLFLYQLE 119 GN VV I DCD D LLVL P GP CH G+ SCF A ++ L +LE Sbjct: 63 GNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNELE 122 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 Q++A+R + PE SYT L+ G +I +KVGEE E +AA + EL EA+DL+YH Sbjct: 123 QIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLYH 182 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 LLVLL++Q L L V+ L +RH Sbjct: 183 LLVLLREQKLPLDAVLATLAERH 205 >UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga RepID=HIS2_THEMA Length = 197 Score = 253 bits (648), Expect = 2e-66, Method: Composition-based stats. Identities = 84/194 (43%), Positives = 112/194 (57%), Gaps = 8/194 (4%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L PV+VQ +GEVLML Y N EAL+ T ++G FFSR +Q++W KGETSGN + VV I Sbjct: 4 LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63 Query: 78 APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQ------WLFLYQLEQLLAERKSAD 129 DCD+D L + + CH G SCF H+ F +L +L+ +RK Sbjct: 64 RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 PE SYT KL+ G +IA+K GEE VE +DR L E +D+MYHL VL+ D G+ Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183 Query: 190 DLTTVIENLRKRHQ 203 + V+ L KR + Sbjct: 184 TVQDVMRELEKRRK 197 >UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus acidocaldarius LAA1 RepID=B7DRK3_9BACL Length = 254 Score = 252 bits (644), Expect = 6e-66, Method: Composition-based stats. Identities = 78/247 (31%), Positives = 115/247 (46%), Gaps = 49/247 (19%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + + + ++ GL+PV+ Q A +GEVLM+ Y + EAL +TL +G ++SR+++ W Sbjct: 7 DVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRREYWR 66 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF------------------ 105 KG TSGN VV + DCD D +L P GP CH G +CF Sbjct: 67 KGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAADEGG 126 Query: 106 --------------------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLY 139 G L +L ++ R P+ SYT L+ Sbjct: 127 AKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTTYLF 186 Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDLTTV 194 G +R+ +K+GEE VE ALA +R E+ +E++DL+YHLLVL + G+ V Sbjct: 187 THGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHPVDV 246 Query: 195 IENLRKR 201 L KR Sbjct: 247 WRTLEKR 253 >UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC Length = 251 Score = 252 bits (643), Expect = 7e-66, Method: Composition-based stats. Identities = 80/237 (33%), Positives = 120/237 (50%), Gaps = 40/237 (16%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + + ++DW+K GL+PV++Q +GEVLM+ YMN EAL+ T +G +FSR+K R+W K Sbjct: 3 ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107 GE+SGN V S DCDNDTLL+ G CH G SCF + Sbjct: 62 GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121 Query: 108 TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 + ++ L +L + +RK +ADP+ SY AKLY G +K+ EE E A A R Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181 Query: 167 F---------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 ++ E +DL++H++V L G+ ++ L +R+ Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238 >UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIV8_9BACT Length = 234 Score = 252 bits (643), Expect = 7e-66, Method: Composition-based stats. Identities = 77/198 (38%), Positives = 110/198 (55%), Gaps = 13/198 (6%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P +VQ G +LML YMN EALD+TL++G V F+SR++++LW KGETSG++L Sbjct: 22 GLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSGHYLLCKR 81 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFG-------------DTAHQWLFLYQLEQLLA 123 + DCD D LLV A P GPTCH +CF +L +++ Sbjct: 82 VFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFDRLYEMVL 141 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 +RK+ E SY + L G RI +KV EE E LA R E+ +E +DL++H +V Sbjct: 142 QRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADLIFHSIVA 201 Query: 184 LQDQGLDLTTVIENLRKR 201 L + +T + + L KR Sbjct: 202 LGHCEIPMTAIQQELGKR 219 >UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 RepID=C8WUY1_ALIAD Length = 256 Score = 251 bits (641), Expect = 1e-65, Method: Composition-based stats. Identities = 80/255 (31%), Positives = 117/255 (45%), Gaps = 54/255 (21%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M + + + ++ GL+PV+ Q A +G+VLML Y + EAL +TL +G ++SR+++ Sbjct: 1 MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105 W KG TSGN VV + DCD D +L P GP CH G CF Sbjct: 61 YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120 Query: 106 ----------------------------------GDTAHQWLFLYQLEQLLAERKSADPE 131 G A L +L ++ R P+ Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186 SYT L+ G +R+ +K+GEE VE ALA +R E+ +E++DL+YHLLVL + Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240 Query: 187 QGLDLTTVIENLRKR 201 G+ V + L KR Sbjct: 241 VGVQPADVWQVLEKR 255 >UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Flavobacteriales RepID=A4CLC1_9FLAO Length = 206 Score = 250 bits (640), Expect = 2e-65, Method: Composition-based stats. Identities = 94/203 (46%), Positives = 129/203 (63%), Gaps = 6/203 (2%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 + +D+EKT GL+P I+Q + + VLMLGYM+ EAL+ T SGKVTF+SR+K+RLWTKGE Sbjct: 1 MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-AHQWLFLYQLEQLLAER 125 +SGNFL V + DCD D LL+ A P GP CH G+ +C+ + FL +LE ++A R Sbjct: 61 SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120 Query: 126 KSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 K SY A L GT ++AQKVGEE VET + A D NE++DL++H Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 L+LLQ +G + + L +RH+ Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203 >UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=Q058A1_BUCCC Length = 205 Score = 250 bits (639), Expect = 2e-65, Method: Composition-based stats. Identities = 93/204 (45%), Positives = 131/204 (64%), Gaps = 1/204 (0%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 ML +Q + L+W K +GL+P I QH +SGE+LM GYMN +A DK + + T +SR K+R Sbjct: 1 MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLE 119 +W KGETS NFL V +I+ DCD D +LV NP G TCH SCF + FLY+LE Sbjct: 61 IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 + +K +SY + L++SG RIAQK+GEE VE +A ++ + NE SDL++H Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180 Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203 L +LLQ ++L +I+NL+KR + Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204 >UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria RepID=HIS2_HELHP Length = 231 Score = 247 bits (632), Expect = 1e-64, Method: Composition-based stats. Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + R++DWE+ + L+P IVQ S ++LML Y + ++L+ +L++ +FSR+KQR+W Sbjct: 2 QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107 KGE SG+ ++ + DCDND+L+ + +G CH G SCF Sbjct: 61 KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120 Query: 108 ---TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 + L L ++ +R+ + E SYTA L A G I +K+ EE E A Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 D + E +DL YH+LV L + + V++ LR+R Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217 >UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Picrophilus torridus RepID=Q6KZD6_PICTO Length = 204 Score = 247 bits (632), Expect = 1e-64, Method: Composition-based stats. Identities = 74/205 (36%), Positives = 116/205 (56%), Gaps = 15/205 (7%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +++ DG++PV+VQ +G+VL L YM+ AL+ T+++G ++SR+ +R+ KGE S Sbjct: 5 NINF--NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVS 62 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF----------GDTAHQWLFLYQL 118 GN V+ I DC++++LL+ GP CH G +SCF G+ + L +L Sbjct: 63 GNTQKVMEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRL 122 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 E L+ +R SYT L SG + I +KVGEE +ET LA+ R + E +DL+Y Sbjct: 123 EDLVRKRMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILAS---GRDRIVYETADLLY 179 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 HL+V L + L V+ L +R + Sbjct: 180 HLIVFLAFNNVSLFDVMNELNRRSK 204 >UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae RepID=D0LRT4_HALO1 Length = 241 Score = 246 bits (628), Expect = 4e-64, Method: Composition-based stats. Identities = 85/204 (41%), Positives = 117/204 (57%), Gaps = 16/204 (7%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L Sbjct: 21 NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---------------GDTAHQWLFLYQL 118 V + DCD D ++V+A P GPTCH GT SCF G + L +L Sbjct: 81 VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140 Query: 119 EQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 E ++A R+ SAD E SYT L G +I K+ EE E A +R E+ +E +DL+ Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 +H++V L + + L V L +R Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224 >UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms RepID=HIS2_PYRFU Length = 209 Score = 245 bits (626), Expect = 6e-64, Method: Composition-based stats. Identities = 90/213 (42%), Positives = 124/213 (58%), Gaps = 14/213 (6%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M E+ +++WEK +G++PVIVQ GEVL L YMN EAL KTLE+G ++SR+K R Sbjct: 1 MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-------- 112 + KGE SGN V I DCDND LL++ +P GP CH G SCF + Sbjct: 60 IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119 Query: 113 --LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L +LE+++ RK E SYT+KL+ G ++I +K GEE +E +A R + Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E +DL+YHLLVLL + L V+ LR+R + Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209 >UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB5_9BACT Length = 188 Score = 245 bits (626), Expect = 6e-64, Method: Composition-based stats. Identities = 88/187 (47%), Positives = 116/187 (62%), Gaps = 5/187 (2%) Query: 22 IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81 +VQ A SGEVLML Y N E++ TLE G++ F+SR+++ +W KG TSGN L + S+ DC Sbjct: 2 VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61 Query: 82 DNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQLLAERKSADPETSYTA 136 D D +L +P+GP CH G SCF G+ +FL +L L +R PE SYTA Sbjct: 62 DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121 Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 +L A R+AQK+GEEGVETALA DR + EA+DL+YHLLV L L + Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181 Query: 197 NLRKRHQ 203 L+KRH+ Sbjct: 182 ELKKRHK 188 >UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium thermophilum RepID=Q67KI1_SYMTH Length = 210 Score = 245 bits (625), Expect = 9e-64, Method: Composition-based stats. Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%) Query: 27 VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86 +G+VLM YMN EAL TLE+G ++SR++Q LW KG TSG+ V I DCD D+L Sbjct: 2 RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61 Query: 87 LVLANPIGPTCHKGTSSCFGDTAHQW-----------------------LFLYQLEQLLA 123 L+L G CH+GT SCF L +L +LA Sbjct: 62 LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 ER++ SYT++L+ G +K+GEE E LA DR L E +DL +H LV Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181 Query: 184 LQDQGLDLTTVIENLRKRH 202 L DQGL V + L R Sbjct: 182 LVDQGLSPADVADQLASRR 200 >UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B858_THEAS Length = 205 Score = 244 bits (624), Expect = 1e-63, Method: Composition-based stats. Identities = 95/202 (47%), Positives = 120/202 (59%), Gaps = 6/202 (2%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++W D L+PV+VQ A SG VLML Y N EALD TL+ G+ FFSR++ RLW KGE Sbjct: 2 TDRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGE 60 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQL 121 TSGN + V+ + DCD D++L L GP CH G SCF G LFL++L ++ Sbjct: 61 TSGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEI 120 Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 + +R S + SYT L+ G RIAQKVGEEGVE ALA DR EA+DL+YHL Sbjct: 121 VDQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLT 180 Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203 V L+ L + L RHQ Sbjct: 181 VALRRVDATLLDAEQVLMARHQ 202 >UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NG19_KYTSD Length = 244 Score = 242 bits (619), Expect = 4e-63, Method: Composition-based stats. Identities = 98/229 (42%), Positives = 128/229 (55%), Gaps = 35/229 (15%) Query: 9 ELDWEKTD----GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 E+D+ + GL+ +VQ A + VLM+G+M+ AL+ T +G+VTF+SR++ W K Sbjct: 15 EVDFSRVTDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVK 74 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF------------------- 105 GETSGN L+VVS+ DCD D +LV+A P GPTCH G +SCF Sbjct: 75 GETSGNTLDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAA 134 Query: 106 ------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEE 153 G T + L + +AER P SYT L+ GT+RIAQKVGEE Sbjct: 135 SGAGGDAPASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEE 194 Query: 154 GVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 GVETALA EL E++DL+YHL+VLL D+GL L V LR R Sbjct: 195 GVETALAGVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243 >UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN Length = 215 Score = 241 bits (616), Expect = 9e-63, Method: Composition-based stats. Identities = 84/205 (40%), Positives = 112/205 (54%), Gaps = 8/205 (3%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 E+ ++ +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++ LW KG Sbjct: 2 NIEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKG 60 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL------- 118 SGN V+ + DCD D +L P GP CH G +CF L Sbjct: 61 AISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKV 120 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 + L R PE SY K++ +G RI +K+GEE E +AA R EL EASDL++ Sbjct: 121 YRTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLF 180 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 HLL L + GL + L +R+Q Sbjct: 181 HLLFTLTELGLSPQDLARVLWERNQ 205 >UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes RepID=C6W0Y7_DYAFD Length = 213 Score = 241 bits (615), Expect = 1e-62, Method: Composition-based stats. Identities = 106/211 (50%), Positives = 137/211 (64%), Gaps = 12/211 (5%) Query: 5 QQRRELDWEKT-DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + +D+ K+ DGL+P ++Q +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT Sbjct: 3 ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWL 113 KGETSGNFL V IA DCD DTLL+ A P GP CH G +CFG+ A + Sbjct: 63 KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122 Query: 114 FLYQLE-QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 FL L+ +++ ERK + SYT+ L+ G +IAQKVGEE VE + + D NE Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 SDL++HLLVLL+ + +DL VI+ LR RHQ Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213 >UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum sp. NBC37-1 RepID=A6Q6T8_SULNB Length = 222 Score = 241 bits (615), Expect = 1e-62, Method: Composition-based stats. Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 +DW K + L+P I Q A + +VLML YMN EA + TL +G +FSR+KQR+W KGE+SG Sbjct: 3 IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115 + V + DCD DT+++ G CH G SCF DT + + Sbjct: 62 HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121 Query: 116 YQLEQLLAERKSADPET-SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L + ERK+A E S+T KL + + K+ EE E +A ++ E++ Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL+YH LV L + + V + L +R Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207 >UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3 Tax=Chloroflexi RepID=B9KXC5_THERP Length = 218 Score = 240 bits (613), Expect = 2e-62, Method: Composition-based stats. Identities = 85/196 (43%), Positives = 118/196 (60%), Gaps = 8/196 (4%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KGETSG+ L + Sbjct: 17 ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKGETSGHVLEL 76 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAERK 126 V + DCD D LL +P GPTCH G SCF L +L ++A R Sbjct: 77 VELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILDELASIIAARA 136 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 SYT+ L +G RIA+K+GEE E +AA + + EA+DL+YHLLVLLQ Sbjct: 137 VEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLLYHLLVLLQA 196 Query: 187 QGLDLTTVIENLRKRH 202 G+ V L+ R Sbjct: 197 SGVPAGEVWRVLQARR 212 >UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2 Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT Length = 233 Score = 240 bits (612), Expect = 3e-62, Method: Composition-based stats. Identities = 89/196 (45%), Positives = 124/196 (63%), Gaps = 6/196 (3%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 + K D L+P +VQH +G+VLMLGYM EA + T +GKVTFFSR+++++W KGETSGN Sbjct: 21 FGKAD-LIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSRKKIWVKGETSGNG 79 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-----HQWLFLYQLEQLLAERK 126 L+V+ I DCD DT+LVLA P+GPTCH G+ SCF + + +L+ + ERK Sbjct: 80 LDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFEVWSELQSTVRERK 139 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 + DP+ SYTA L S + +K+ EE E +LA V R +E +DL +H+ V L+ Sbjct: 140 TGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEWADLFFHIAVALEK 199 Query: 187 QGLDLTTVIENLRKRH 202 G+ V+E LRKR Sbjct: 200 TGVSWGEVMEILRKRQ 215 >UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR Length = 204 Score = 239 bits (611), Expect = 4e-62, Method: Composition-based stats. Identities = 95/203 (46%), Positives = 129/203 (63%), Gaps = 1/203 (0%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT Q +L+W+K + L+P+IVQ S E+LM GY N ++L TL+ K+TFFSRTK R Sbjct: 1 MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH-QWLFLYQLE 119 LWTKGETS N+L V+ I PDCD D+LL L IG TCH SCF + F+ +LE Sbjct: 61 LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 ++L K + TSYT+ LY G +I+QKVGEE VE +AA D+ + E +DL+YH Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 +LVL + +I+ L+KR+ Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203 >UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria RepID=HIS2_AQUAE Length = 205 Score = 238 bits (607), Expect = 1e-61, Method: Composition-based stats. Identities = 74/199 (37%), Positives = 113/199 (56%), Gaps = 9/199 (4%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 +GL+PVI Q +GEV ML Y N EA+ KTLE+G ++SR+++++W KGETSG Sbjct: 7 NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETSGELQK 66 Query: 74 VVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFGDTAH--------QWLFLYQLEQLLAE 124 V+ + DCD D L+ + CH G +CF + L +L+ ++ E Sbjct: 67 VIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQDVIRE 126 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 + E SYTAKL + G +R+ QK GEE VET +A ++ E+ E++D++Y LV L Sbjct: 127 KIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYTFLVSL 186 Query: 185 QDQGLDLTTVIENLRKRHQ 203 G+D+ V+E L +R + Sbjct: 187 SVSGIDIKEVMEELIRRFK 205 >UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms RepID=HIS2_THET2 Length = 214 Score = 236 bits (602), Expect = 4e-61, Method: Composition-based stats. Identities = 81/192 (42%), Positives = 115/192 (59%), Gaps = 5/192 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGETSG+ VV Sbjct: 12 GLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVE 71 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-----AHQWLFLYQLEQLLAERKSADPE 131 + DCD D ++ P GP CH G +CF + Q+ + ER PE Sbjct: 72 VLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYATIKERLRTLPE 131 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 SY A+++ +G RI +K+GEE E LAA + EL +EA+DL++HLL+ L + GL Sbjct: 132 GSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLLLTLAELGLTP 191 Query: 192 TTVIENLRKRHQ 203 + + L +RH+ Sbjct: 192 EDLAKTLWERHR 203 >UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS Length = 257 Score = 235 bits (599), Expect = 1e-60, Method: Composition-based stats. Identities = 82/244 (33%), Positives = 116/244 (47%), Gaps = 43/244 (17%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M Q E+ + GL+P I QH +G +LM+ +MN E+L T E + +FSR++Q+ Sbjct: 1 MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF-------------- 105 LW KGE SG+F V I DCD D +++ G CH G SCF Sbjct: 60 LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119 Query: 106 --------------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKR 145 T Q L L QL+ ERK A+ +TSY + LY G + Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179 Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198 I +KVGEEGVET +AA + +L E +DL +H +V+L L+ +I+ L Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239 Query: 199 RKRH 202 +R Sbjct: 240 GRRQ 243 >UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT Length = 230 Score = 233 bits (594), Expect = 3e-60, Method: Composition-based stats. Identities = 87/197 (44%), Positives = 116/197 (58%), Gaps = 10/197 (5%) Query: 15 TDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 DG L PV+ Q G+VLM+GYMN EA +T+E G+VTFFSR+++RLWTKGE+SG+FL Sbjct: 11 PDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWTKGESSGHFL 70 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------DTAHQWLFLYQLEQLLAE 124 +VS+ DCD DTLL L P GPTCH GT SCF + + L L +A Sbjct: 71 RLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETLGDLAGTIAL 130 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R+ DPETSY A+L + + +K+ EE ET A D +E +DL++HLLV + Sbjct: 131 RRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMADLLFHLLVAM 190 Query: 185 QDQGLDLTTVIENLRKR 201 + V+ L KR Sbjct: 191 ERTRTPWEEVVGVLEKR 207 >UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4L5_GEMAT Length = 207 Score = 233 bits (594), Expect = 4e-60, Method: Composition-based stats. Identities = 81/204 (39%), Positives = 112/204 (54%), Gaps = 5/204 (2%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M + LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++ Sbjct: 1 MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KG TSG+ V+S+A DCD D +L GP CH GT+SCF DTA + L+ Sbjct: 60 LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119 Query: 121 LLAERKS---ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 +A R+ D SYT +L R +K+GEE VE A A D T E +DL+ Sbjct: 120 TIAARQQSLRDDERPSYTQRLLTDRNLR-LKKLGEEAVELATACVDGDVERATEETADLL 178 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 YH LV L+ G L V L +R Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202 >UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase n=2 Tax=Francisella philomiragia RepID=B0TY40_FRAP2 Length = 207 Score = 231 bits (590), Expect = 1e-59, Method: Composition-based stats. Identities = 102/201 (50%), Positives = 137/201 (68%), Gaps = 3/201 (1%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + + W+K D L+P I+Q A+ VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTK Sbjct: 4 KIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTK 63 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL--FLYQLEQLL 122 GE SGNFL + IA DCDND++L+ A P GPTCH G+ SCF + +LE+L+ Sbjct: 64 GEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLI 123 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMYHLL 181 AE+K PE SY L+ G RIAQKVGEEGVE +AA D EL +E +DL++HLL Sbjct: 124 AEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLL 183 Query: 182 VLLQDQGLDLTTVIENLRKRH 202 VLL+++G+ L + + L R+ Sbjct: 184 VLLREKGISLEQICQKLVSRN 204 >UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5 Length = 229 Score = 229 bits (585), Expect = 4e-59, Method: Composition-based stats. Identities = 85/199 (42%), Positives = 113/199 (56%), Gaps = 15/199 (7%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P +VQ ++G+V ML YM E+L +TLE+G+ TFFSR++ LW KG TSGN L V S+ Sbjct: 10 LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCF-------GDTAHQWLFLYQ--------LEQLL 122 DCD D LL+LA P GPTCH G++SCF GD + Q LE+ L Sbjct: 70 HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 RK++ SYT KL G I K+ EE E A A + +EA+D++YHLLV Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189 Query: 183 LLQDQGLDLTTVIENLRKR 201 L +G+ L V+ L R Sbjct: 190 GLASRGVPLRAVLSALASR 208 >UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD Length = 202 Score = 229 bits (584), Expect = 5e-59, Method: Composition-based stats. Identities = 76/200 (38%), Positives = 109/200 (54%), Gaps = 9/200 (4%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+ W KG Sbjct: 4 LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER- 125 TSGN VV++ DCD D +L GP CH GT +CFG +W L L+ LA R Sbjct: 63 TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFG--PGRWDALSALDDTLARRA 120 Query: 126 ----KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 + D SYT +L R +K+GEE E A D EA+D++YH+L Sbjct: 121 APAERPDDAPPSYTRRLLEDRNLR-LKKLGEEAAELVTACADVDPSRAAEEAADVLYHVL 179 Query: 182 VLLQDQGLDLTTVIENLRKR 201 V ++ GL L V L +R Sbjct: 180 VAVRPLGLSLDDVKAVLARR 199 >UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii RepID=A8HTA8_CHLRE Length = 308 Score = 223 bits (569), Expect = 3e-57, Method: Composition-based stats. Identities = 73/226 (32%), Positives = 117/226 (51%), Gaps = 31/226 (13%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 L W+K + L+ VIVQH +GEV+M + + A+ +TL++G TF+SR++ W K Sbjct: 67 SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH-------------- 110 GETSG+F+NV ++ DCD D+++ L++PIGP CH G +C+ Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185 Query: 111 --------QWLFLYQLEQLLAERKSAD------PETSYTAKLYASGTKRIAQKVGEEGVE 156 L LE+ +A+R+ A + S+TA+L + + + +K+ EE E Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGE 244 Query: 157 TALAA-TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 R +E +DL+YH +VL QG+ + V+ LRKR Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290 >UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU Length = 284 Score = 213 bits (544), Expect = 2e-54, Method: Composition-based stats. Identities = 70/219 (31%), Positives = 112/219 (51%), Gaps = 25/219 (11%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 L ++ GL+ I Q +G +LM G+ + +A+ TL + K TF+SR++ LW KG Sbjct: 46 FLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCKG 104 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD------------------ 107 ETSGNF+ V S+ DCD D+L+ L P GPTCH G +C+ Sbjct: 105 ETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRHA 164 Query: 108 TAHQWLFLYQLEQLLAERK----SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-AT 162 LY+LE + R+ + D + S+T +L + + + +K+ EE E Sbjct: 165 AEEALTTLYELEATIEARRVEAVADDVKPSWTRRLLDN-PELLCKKIREEAGELCQTWEE 223 Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + TNE +D++YH +V+L QG+ ++ V+ LR+R Sbjct: 224 NEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262 >UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta RepID=HIS2_ARATH Length = 281 Score = 211 bits (537), Expect = 1e-53, Method: Composition-based stats. Identities = 75/220 (34%), Positives = 117/220 (53%), Gaps = 25/220 (11%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 + + W+ GL I Q+ +G VLM G++N EAL T+ S K TFFSR++ LW Sbjct: 52 VDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTLW 110 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ----- 117 TKGETS NF+N++ + DCD D+++ L P GPTCH G +C+ + L + Sbjct: 111 TKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGNK 170 Query: 118 --------LEQLLAERKSADP-----ETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 LE ++++RK + S+T +L + K+ EE E T+ Sbjct: 171 LALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADELC--RTLE 227 Query: 165 DRFELT---NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 D E++ +E +D++YH +VLL +G+ + V+E LRKR Sbjct: 228 DNEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267 >UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2 Tax=Campylobacter RepID=B9D5P8_WOLRE Length = 329 Score = 210 bits (535), Expect = 2e-53, Method: Composition-based stats. Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++DW+K GL+P +VQ + SGEVLML YMN EAL+ +L++G +FSRTK R+W KGE S Sbjct: 2 KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107 GN + I DCDNDT+L+ G CH G SCF Sbjct: 62 GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121 Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159 + + ++ + +RK +ADP+TSY A L+ G I +KVGEE E + Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181 Query: 160 AATVHD 165 A Sbjct: 182 ACKDAS 187 Score = 54.4 bits (130), Expect = 2e-06, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 18/35 (51%) Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E+ EA+DL +H LV L G+ V L +R Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 209 bits (533), Expect = 4e-53, Method: Composition-based stats. Identities = 67/193 (34%), Positives = 102/193 (52%), Gaps = 6/193 (3%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 LD++K L+P IVQ +G VLML Y PE+L + K +FSR++ LW KG TSG Sbjct: 224 LDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNELWEKGLTSG 282 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 N +++I DCD DTL+ G CH SCF + + L L+++ +R + Sbjct: 283 NQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANF-DLDVLDRVFEQRMQSQ 341 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 TS++ KL AS +K+ EE E A D+ E+ EA+DL++ L + +G+ Sbjct: 342 EVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFALARAKSKGV 397 Query: 190 DLTTVIENLRKRH 202 + +I L R+ Sbjct: 398 AASDIINELGARN 410 >UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms RepID=HIS2_YEAST Length = 799 Score = 206 bits (524), Expect = 4e-52, Method: Composition-based stats. Identities = 67/203 (33%), Positives = 104/203 (51%), Gaps = 9/203 (4%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT++ E+ ++ DGL +V L L Y + +++ K ++ G+ ++SR++ Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLE 119 +W KGETSGN ++ I+ DCD+D L + CH T SCFG+ H + LE Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVG---LE 249 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 LL +R PE SYT +L+ + + + K+ EE E A + EL+ EA+DL Y Sbjct: 250 SLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 L L + L V NL +H Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328 >UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HFX2_CHAGB Length = 817 Score = 194 bits (494), Expect = 1e-48, Method: Composition-based stats. Identities = 62/189 (32%), Positives = 94/189 (49%), Gaps = 10/189 (5%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 ++ DGL+P +V L L Y + E++ + L++ + SR + LW KG TSG+ Sbjct: 204 DRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGDTQ 261 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132 +V I+ DCDND L + G CH S CFGD L +LE L RK + P Sbjct: 262 ELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDLKG----LAKLESTLLSRKQSAPAG 317 Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192 SYTA+L++ K + K+ EE E A + + EA+DL+Y L G+ L Sbjct: 318 SYTARLFS-DEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVTLA 373 Query: 193 TVIENLRKR 201 + ++L + Sbjct: 374 DIEKSLDAK 382 >UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira pseudonana RepID=B8BUA9_THAPS Length = 272 Score = 193 bits (490), Expect = 4e-48, Method: Composition-based stats. Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 13/198 (6%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + ++ DGL +V SGE L L Y + E++ L+SG+ ++SR++ LW KG+TSG Sbjct: 59 VKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSG 117 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125 +F + + DCD D L G CH T +C+G+ L LE L +R Sbjct: 118 HFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEPRG----LRHLEGTLQQR 173 Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185 P SYT +L+ + K+ EE E + A + + E +D++Y +V Sbjct: 174 LKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRAA 229 Query: 186 DQGLDLTTVIENLRKRHQ 203 G+ + +E L +R + Sbjct: 230 KAGVSIDDAVEELDRRTR 247 >UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria RepID=Q2PPB3_PHANO Length = 881 Score = 192 bits (489), Expect = 6e-48, Method: Composition-based stats. Identities = 66/198 (33%), Positives = 102/198 (51%), Gaps = 17/198 (8%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 ++ DGL +V G L L Y + E++ ++L +G+ + SR + LW KGE+SG+ Sbjct: 202 DRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-LWYKGESSGDIQ 259 Query: 73 NVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131 +VS++ DCD+D L + G CH T +CFGD + L +L++ L RK + P+ Sbjct: 260 ELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQKTLQSRKESAPQ 315 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 SYTA+L+ + + + K+ EE E A T + + EA+DL Y L G+ L Sbjct: 316 GSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFALTKCVAAGVSL 371 Query: 192 TTVIENLR------KRHQ 203 V NL KR Q Sbjct: 372 EDVERNLDAKSIKVKRRQ 389 >UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira RepID=B5VZW9_SPIMA Length = 200 Score = 188 bits (478), Expect = 1e-46, Method: Composition-based stats. Identities = 58/200 (29%), Positives = 95/200 (47%), Gaps = 18/200 (9%) Query: 6 QRRELDWEKTD--GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 ++D + D GL+ + +Q ++G VL LG MN EAL KTL + ++ + +++ LW Sbjct: 17 NLIDIDKIRYDDQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWH 76 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 + + SI+ D + L+ C + G T L L +++ Sbjct: 77 P------DIILESISYDYRGNFLVAGV----AYCPSELNGSGGHT------LAGLFRVIC 120 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 +R+ SYT +L+A G +I +K+GEE E +A + + +E +DL YH LV Sbjct: 121 DRRDHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVA 180 Query: 184 LQDQGLDLTTVIENLRKRHQ 203 L +DL V E L R Q Sbjct: 181 LAYHQVDLRKVYEQLEARRQ 200 >UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN Length = 198 Score = 186 bits (474), Expect = 3e-46, Method: Composition-based stats. Identities = 53/190 (27%), Positives = 87/190 (45%), Gaps = 12/190 (6%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P I+Q + G VL L +M+ ++L KT E +V + L + +G + Sbjct: 21 NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLLITGWRYD 80 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133 P C + +LV I ++ F + L ++ +++ +R+ E S Sbjct: 81 -----PACQSLLILVECGSIAEPQNE-----FAQVSSNLL--SEVFEVICDRRDHPQEDS 128 Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193 YT KL A G +I +K+GEE E +A D + +E +DL YH LV + DL Sbjct: 129 YTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAYHRADLRQ 188 Query: 194 VIENLRKRHQ 203 V L +R + Sbjct: 189 VYRKLAERRR 198 >UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces RepID=HIS2_SCHPO Length = 417 Score = 186 bits (473), Expect = 3e-46, Method: Composition-based stats. Identities = 63/203 (31%), Positives = 102/203 (50%), Gaps = 11/203 (5%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L + + ++ DGL +V + + G L L Y + E++ ++L++G + SR + L Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120 W KG +SG +++ I DCD D L + G CH T CFG + L QLE+ Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASG----LCQLEK 308 Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 L +RK+ PE SYTA+L++ K + K+ EE E A T + + E +DLMY Sbjct: 309 TLIDRKNNAPEGSYTARLFS-DPKLLRAKIMEEAEELCDATT---KENVIWEMADLMYFA 364 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 + G+ L + +L +H+ Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387 >UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota RepID=Q4P7D9_USTMA Length = 896 Score = 184 bits (467), Expect = 2e-45, Method: Composition-based stats. Identities = 61/208 (29%), Positives = 94/208 (45%), Gaps = 13/208 (6%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + L ++TDGL V + L L Y +P ++ K++ +G + SR + L Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CH-KGTSSCFGDTAHQWLFL 115 W KGE+SG VVSI DCD+D + T CH + CF L Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSATG----L 307 Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 +LE L R P SYTA+L+ + + K+ EE E A A +D+ + EA+D Sbjct: 308 AKLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAAD 365 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L+Y L G+ L + +L + + Sbjct: 366 LIYFALTKCVSAGIGLEEIEASLDAKAK 393 >UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4CVB3_9BACT Length = 128 Score = 173 bits (439), Expect = 3e-42, Method: Composition-based stats. Identities = 51/123 (41%), Positives = 70/123 (56%), Gaps = 4/123 (3%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P IVQ + VLM+ +MN +L+ TL++G + ++SR++Q+ W KGETSG+ V Sbjct: 10 ADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGETSGHTQKV 69 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134 V A DCD DTLL IG CH G SCF + + E K DPE +Y Sbjct: 70 VRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSPEGTPLE----ITEEKLFDPEKTY 125 Query: 135 TAK 137 +K Sbjct: 126 ASK 128 >UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN Length = 477 Score = 173 bits (438), Expect = 5e-42, Method: Composition-based stats. Identities = 59/193 (30%), Positives = 90/193 (46%), Gaps = 10/193 (5%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 L ++ D L +V +G L L Y + E++ + SG+ ++SR++ LW KGE+SG Sbjct: 249 LRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKKGESSG 307 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 N ++ I DCD+D L N G CH T +C+G L LE +L R Sbjct: 308 NAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHDGG----LRALESMLFSRHEN 363 Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 P SYT +L+ + + K+ E A ++ EA+D+MY +V G Sbjct: 364 APAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVRCVAAG 419 Query: 189 LDLTTVIENLRKR 201 L+ V L KR Sbjct: 420 CKLSDVERMLDKR 432 >UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms RepID=HIS3_STRTD Length = 112 Score = 170 bits (432), Expect = 2e-41, Method: Composition-based stats. Identities = 47/103 (45%), Positives = 65/103 (63%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +LD++K GL+PVIV +G+VLML YMN + TLE+ ++ ++SR++ LW KG TS Sbjct: 5 KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111 G+F +V SI DCD DTLL+ G CH G SCF + Sbjct: 65 GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYD 107 >UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria RepID=C4XTP1_DESMR Length = 124 Score = 167 bits (424), Expect = 2e-40, Method: Composition-based stats. Identities = 54/99 (54%), Positives = 67/99 (67%), Gaps = 1/99 (1%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 D+ K GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+ Sbjct: 5 DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64 Query: 71 FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT 108 V S+ DCD DT+LVL I G CH+G SCF Sbjct: 65 VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFFTE 103 >UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT Length = 116 Score = 166 bits (422), Expect = 3e-40, Method: Composition-based stats. Identities = 41/106 (38%), Positives = 61/106 (57%), Gaps = 2/106 (1%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 +L + D L+P I Q G VLM+ +MN E++ KTL +G+ ++SR++ +LW KG T Sbjct: 9 EKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKGAT 67 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112 SG+ V + DCD DT+L+ IG CH G SCF + + Sbjct: 68 SGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113 >UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms RepID=HIS3_SOLUE Length = 126 Score = 166 bits (421), Expect = 4e-40, Method: Composition-based stats. Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 7/130 (5%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 LD+ K+DGL+ ++Q SG VLM+GYMN EA +KT+E+G TF+SR++++LW KGE+S Sbjct: 2 NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127 G+ L V I+ DCD D +LV GP CH+G SCF L E +A+ + Sbjct: 62 GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFR------RLDAGEWKVADNPT 115 Query: 128 ADPETSYTAK 137 DP Y K Sbjct: 116 YDPGAVYGGK 125 >UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms RepID=HIS3_PELLD Length = 137 Score = 166 bits (420), Expect = 5e-40, Method: Composition-based stats. Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 6/133 (4%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + ++ GL+P IVQ +G+VLM+ +MN E+L+ TLE K ++SR++ +LW K Sbjct: 10 SFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLK 68 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 GE+SGN +V I DCD DTL++ + IG CH G SCF + + + + Sbjct: 69 GESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYRRVLENGNME-----ICD 123 Query: 125 RKSADPETSYTAK 137 DPE Y K Sbjct: 124 TLMFDPEEVYGKK 136 >UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050F746 Length = 123 Score = 166 bits (420), Expect = 6e-40, Method: Composition-based stats. Identities = 48/103 (46%), Positives = 67/103 (65%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 T + REL +DGL+PVIVQ + EVLM+ +M+ EA+++TL +G ++SR++Q W Sbjct: 13 TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 KGETSGN V S++ DCD D LL+ GP CH T +CF Sbjct: 73 VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCF 115 >UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae RepID=HIS3_FRAAA Length = 132 Score = 164 bits (417), Expect = 1e-39, Method: Composition-based stats. Identities = 46/89 (51%), Positives = 62/89 (69%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL P I Q +GEVLMLG+M+ EAL +TL +G+ T++SR++ W KG+TSG+ V S Sbjct: 22 GLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQWVRS 81 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 +A DCD D +LV + IGP CH GT +CF Sbjct: 82 VALDCDGDAVLVRVDQIGPACHTGTRNCF 110 >UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota RepID=HIS3_HALWD Length = 132 Score = 164 bits (417), Expect = 1e-39, Method: Composition-based stats. Identities = 54/126 (42%), Positives = 74/126 (58%), Gaps = 10/126 (7%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 E+ + +DGL+P I Q A SGEVLML Y++P AL +T E+G+ ++SR+++ LW KGETS Sbjct: 16 EIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWKKGETS 74 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 G+ ++ I DCD DT+L L G CH G SCF T L+ + Sbjct: 75 GHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRT---------LDGTEVTERVF 125 Query: 129 DPETSY 134 DPET Y Sbjct: 126 DPETVY 131 >UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria RepID=B8J3P0_DESDA Length = 137 Score = 164 bits (416), Expect = 2e-39, Method: Composition-based stats. Identities = 45/99 (45%), Positives = 66/99 (66%), Gaps = 3/99 (3%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 D+ K GL+P I Q SGEVLML YMN EA KTLE+G+ ++SR+++++W KG TSG+ Sbjct: 19 DFSK--GLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGH 76 Query: 71 FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT 108 V+++ DCD+DT+L+ + + G CH G +CF Sbjct: 77 IQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE 115 >UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria RepID=HIS3_THICR Length = 147 Score = 164 bits (415), Expect = 2e-39, Method: Composition-based stats. Identities = 48/126 (38%), Positives = 66/126 (52%), Gaps = 8/126 (6%) Query: 5 QQRRELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56 QQ DWE +GL+P I Q S EVLM+ +MN AL +TLE+G+V ++SR Sbjct: 14 QQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSR 73 Query: 57 TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLY 116 ++Q W KGE SG + + DCD D +L+L + GP CH G SCF H Sbjct: 74 SRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKI 133 Query: 117 QLEQLL 122 ++ Sbjct: 134 LTNPII 139 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 164 bits (415), Expect = 2e-39, Method: Composition-based stats. Identities = 50/98 (51%), Positives = 66/98 (67%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GL+PV+VQ V+ EVLML YMN EA +KTLE+G +T++SR++Q LW KG TSG+F V Sbjct: 263 ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQYV 322 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112 S+ DCDNDT+L +G CH G +CF W Sbjct: 323 GSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTW 360 >UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae RepID=HIS3_ACIC1 Length = 142 Score = 163 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 45/89 (50%), Positives = 62/89 (69%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL P + Q +GEVLM+G+M+ EAL +TL +G+ T++SR++Q W KGETSG+ V S Sbjct: 22 GLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQWVKS 81 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 +A DCD DT+LV + IG CH G +CF Sbjct: 82 VALDCDGDTVLVKVDQIGAACHTGDRTCF 110 >UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria RepID=HIS3_DINSH Length = 119 Score = 163 bits (413), Expect = 3e-39, Method: Composition-based stats. Identities = 44/106 (41%), Positives = 65/106 (61%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q W KGE+SG+ +V Sbjct: 14 GLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGESSGHVQTLVE 73 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122 + DCD D LL+ GP CH +CF + + ++ Sbjct: 74 MRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119 >UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=A4GIE4_9BACT Length = 132 Score = 163 bits (413), Expect = 3e-39, Method: Composition-based stats. Identities = 42/105 (40%), Positives = 67/105 (63%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P I Q +GEVLM+ +MN +L +TL +G++ ++SR+++ LW KG+TSG+ + Sbjct: 15 ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119 + + DCD D++LVL + G CH+GT SCF + + E Sbjct: 75 IELRYDCDADSILVLVDQSGAACHEGTRSCFTRRLEIDGSISEAE 119 >UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria RepID=HIS3_CORJK Length = 127 Score = 163 bits (413), Expect = 4e-39, Method: Composition-based stats. Identities = 42/92 (45%), Positives = 57/92 (61%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 DGL+P IVQ +G+VLM+ +MN AL TL + K T++SR++Q W KGETSG+ Sbjct: 30 NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIKGETSGHTQR 89 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 V + DCD DT+L+ G CH G +CF Sbjct: 90 VEEVRLDCDGDTVLLKIEQTGAACHTGNRTCF 121 >UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured crenarchaeote RepID=Q702A1_9CREN Length = 115 Score = 163 bits (412), Expect = 4e-39, Method: Composition-based stats. Identities = 42/104 (40%), Positives = 65/104 (62%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 ++ +LD+ K DGL+PV+VQ + ++LML Y N A++ T+++G F+S ++ +LW Sbjct: 7 DEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWM 66 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107 KGE SGN V I DCD D++L L + P CH G +CF + Sbjct: 67 KGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHN 110 >UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3 Length = 140 Score = 162 bits (411), Expect = 5e-39, Method: Composition-based stats. Identities = 48/125 (38%), Positives = 69/125 (55%), Gaps = 5/125 (4%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + ++K +GL+P I Q +G+VLML YMN E+L+ TL+ K ++SR++Q LW KG TSG Sbjct: 15 VRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLKGATSG 73 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 NF V+ I+ DCD D +L+ G CH G SCF + ++ D Sbjct: 74 NFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVENDNSSLS----ICDKLVFD 129 Query: 130 PETSY 134 E Y Sbjct: 130 AEEVY 134 >UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R0U5_9PLAN Length = 310 Score = 162 bits (411), Expect = 6e-39, Method: Composition-based stats. Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 1/125 (0%) Query: 11 DWEKTD-GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 D+ + + L+P I Q +GEVLM+ +MN E+ +T+ +G+ ++SR++ +LW KGE SG Sbjct: 173 DFSRGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESG 232 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 + V + DCD DT+L+ + +G CH+G SCF E+L+ Sbjct: 233 HMQTVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYK 292 Query: 130 PETSY 134 S+ Sbjct: 293 NPKSH 297 >UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268 RepID=C8PI34_9PROT Length = 336 Score = 161 bits (409), Expect = 1e-38, Method: Composition-based stats. Identities = 51/101 (50%), Positives = 61/101 (60%), Gaps = 1/101 (0%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++DW+K GL+P IVQ A G VLML YMN EAL TL +G +FSR+K R+W KGE S Sbjct: 2 KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDT 108 G+ V S DCDND LL+ G CH G SCF Sbjct: 62 GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKE 102 Score = 69.1 bits (168), Expect = 8e-11, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 49/132 (37%), Gaps = 24/132 (18%) Query: 93 IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVG 151 + + + L ++ + +RK + +P SY A LYA G +K+ Sbjct: 194 DAAAQNSTLENSA--EKGPYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251 Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190 EE E ALA R EL + + D++Y LL+ L + Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311 Query: 191 LTTVIENLRKRH 202 +++ L +R Sbjct: 312 PDALLDELARRQ 323 >UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria RepID=HIS3_BURS3 Length = 138 Score = 161 bits (408), Expect = 1e-38, Method: Composition-based stats. Identities = 47/132 (35%), Positives = 73/132 (55%), Gaps = 10/132 (7%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ W+ +GL+PVI Q A + +VLM +MN EAL KT+E+ + ++SR+++RLW KGE Sbjct: 12 LDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGE 70 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF---GDTAHQWLFLYQLEQLL 122 SG+ +V + DCD D +L+ + G CH G SCF + +E +L Sbjct: 71 ESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVEPVL 130 Query: 123 AERKSADPETSY 134 + PE Y Sbjct: 131 KD-----PEHIY 137 >UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria RepID=HIS3_SILST Length = 129 Score = 161 bits (408), Expect = 1e-38, Method: Composition-based stats. Identities = 43/92 (46%), Positives = 60/92 (65%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+P I Q SGE+LM+ +MN E++ KTLE+G+VT++SR++Q W KGE+SG+ +V Sbjct: 24 GLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQELVE 83 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 + DCD D LL + GP CH SCF Sbjct: 84 LRVDCDRDALLAMVRQTGPACHTNRRSCFYTA 115 >UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria RepID=HIS3_CHLP8 Length = 137 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + + ++ GL+P IVQ +G+VLM+ +MN E+L TLE K ++SR++ +LW Sbjct: 9 KSFLETVKFDDR-GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 KGE+SGN +V I DCD DTLL+ + G CH G SCF + + Sbjct: 68 KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQME-----IC 122 Query: 124 ERKSADPETSYTAK 137 + DPE Y K Sbjct: 123 DTLMFDPEEVYGKK 136 >UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class) RepID=HIS3_CLAMS Length = 138 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 50/118 (42%), Positives = 70/118 (59%), Gaps = 8/118 (6%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P ++Q + EVLMLGYM+ EAL +TL +G+VTF+SR++ W KG+TSG+ V Sbjct: 28 DGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYWRKGDTSGHGQYVR 87 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133 A DCD DT+LV + +G CH GT +CF L + R +AD + Sbjct: 88 DAALDCDGDTVLVQVDQVGVACHTGTRTCF--------DADHLHPVTGARPAADEGPT 137 >UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XNB8_HIRBI Length = 139 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 41/94 (43%), Positives = 57/94 (60%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 +DGL+ I Q S EVLML +MN +AL T+E+G+ ++SR++ +LW KG+TSG + Sbjct: 30 NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107 V SI DCD D +L+ CH G SCF Sbjct: 90 VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYR 123 >UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria RepID=Q2SLC2_HAHCH Length = 139 Score = 160 bits (406), Expect = 2e-38, Method: Composition-based stats. Identities = 45/103 (43%), Positives = 66/103 (64%), Gaps = 1/103 (0%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 EL + GL+PVI Q A + +LM +MN EAL+KT+ + ++T++SR++QRLW Sbjct: 21 PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106 KGETSG+ +VS++ DCD D +L L + G CH G +CF Sbjct: 80 KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFY 122 >UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria RepID=HIS3_RALEJ Length = 135 Score = 160 bits (405), Expect = 3e-38, Method: Composition-based stats. Identities = 49/140 (35%), Positives = 76/140 (54%), Gaps = 10/140 (7%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + ++ ++ W+ +GL+PVIVQ + +VLM +MN +AL KT E G+ F+SR+++RL Sbjct: 1 MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCF---GDTAHQWLFLYQ 117 W KGE SG+ V + DCD D +L+ + CH G SCF + + Sbjct: 60 WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEGDAESGDWQT 119 Query: 118 LEQLLAERKSADPETSYTAK 137 +E +L + P YTAK Sbjct: 120 VEPVLKD-----PSQIYTAK 134 >UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms RepID=HIS3_GEOSF Length = 126 Score = 159 bits (404), Expect = 4e-38, Method: Composition-based stats. Identities = 48/127 (37%), Positives = 71/127 (55%), Gaps = 7/127 (5%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++D++K GL+P ++Q SGEVLM+ +M+ + LD TL+ GK FFSRT+ + W KGE S Sbjct: 3 KIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGEES 62 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127 GN V+ + DCD DT+++ GP CH G SCF ++ + + Sbjct: 63 GNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCF------YVKWEDGQWVEHSNPL 116 Query: 128 ADPETSY 134 DP Y Sbjct: 117 FDPNEVY 123 >UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM Length = 151 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 45/105 (42%), Positives = 60/105 (57%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P + Q A +G+VLML +MN A++KTLE+G++T+FSR++ LW KG SGN Sbjct: 41 NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVKGLASGNHQQ 100 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118 +V DCD D LL G CH G SCF A+ L Sbjct: 101 LVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145 >UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria RepID=HIS3_SALRD Length = 127 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 44/106 (41%), Positives = 63/106 (59%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+P IVQ A + +VLM+ YM E L +TL++G++ ++SR++Q W KG+TSG+ V Sbjct: 14 DGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQERWVKGQTSGHTQTVE 73 Query: 76 SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 DCD DTLL + G CH G SCF A + E++ Sbjct: 74 EARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAADDGWTTDGEKV 119 >UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria RepID=HIS3_RHOPS Length = 147 Score = 159 bits (402), Expect = 6e-38, Method: Composition-based stats. Identities = 45/118 (38%), Positives = 67/118 (56%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ + A SGEVLM+ +MN EAL+KT++SG+ ++SR+++RLW KGE+SG+ V+ Sbjct: 28 GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGHVQRVLE 87 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134 I DCD D + + G CH G SCF + L ++ + DP Y Sbjct: 88 IRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTMVDADRLFDPAKIY 145 >UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SGQ9_9ACTO Length = 444 Score = 159 bits (402), Expect = 6e-38, Method: Composition-based stats. Identities = 43/96 (44%), Positives = 59/96 (61%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+ +V+ SGEVLM+ +M+ EAL +TL +G+ T++SR++ W KG TSGN V Sbjct: 341 PDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQYV 400 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH 110 S+A DCD D LLV +G CH G +CF Sbjct: 401 RSVALDCDGDALLVSVEQVGAACHTGQRTCFFTELP 436 >UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria RepID=HIS3_RHOPT Length = 151 Score = 159 bits (402), Expect = 6e-38, Method: Composition-based stats. Identities = 47/122 (38%), Positives = 72/122 (59%), Gaps = 3/122 (2%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 GL+ V+ A +G+VLM+ +MN EALD+T+++G+ ++SR+++RLW KGETSG+ V Sbjct: 29 AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGHIQKV 88 Query: 75 VSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLF-LYQLEQLLAERKSADPET 132 + + DCD D + + + G CH G SCF + L + AERK DP+ Sbjct: 89 LEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLIETDAERK-FDPDK 147 Query: 133 SY 134 Y Sbjct: 148 VY 149 >UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria RepID=HIS3_BIFLI Length = 136 Score = 159 bits (402), Expect = 7e-38, Method: Composition-based stats. Identities = 44/101 (43%), Positives = 63/101 (62%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ ++Q + EVLM+GYMN EAL +TL +G+VTF+SR++Q W KG+TSG+ V Sbjct: 26 GLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQYVKG 85 Query: 77 IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117 ++ DCD D LLV + +G CH G SCF + + Sbjct: 86 VSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 126 >UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms RepID=HIS3_METTH Length = 138 Score = 158 bits (401), Expect = 8e-38, Method: Composition-based stats. Identities = 44/128 (34%), Positives = 68/128 (53%), Gaps = 7/128 (5%) Query: 10 LDWEKT-DG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 L++ +G L+ + Q +GEVLM+ YMN EAL +TLE+G ++S ++ +LW KGE Sbjct: 12 LNFRHNINGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGE 71 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 +SG+ V + DCD D +++ G CH G SCF + + + + K Sbjct: 72 SSGHVQRVKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----K 127 Query: 127 SADPETSY 134 DPE Y Sbjct: 128 VFDPEEIY 135 >UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA Length = 126 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 42/106 (39%), Positives = 60/106 (56%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P I Q A +G VLML +MN EA D+T+ + +FSR++ +LW KG+TSG+ V I Sbjct: 21 LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 DCD DT+L+ G CH+ SCF + E+ +A Sbjct: 81 RVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERIA 126 >UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria RepID=HIS3_ACIAC Length = 141 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 11/132 (8%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 E+ W+ GL+PVI Q A +G+VLM +MN EAL KT E G+ +FSR++ RLW KGE Sbjct: 16 LDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGE 74 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122 SG+ V I DCDND +L+ + G CH G SCF ++ +L Sbjct: 75 ESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSVLKDGA-WQAVDPVL 133 Query: 123 AERKSADPETSY 134 + PE+ Y Sbjct: 134 KD-----PESIY 140 >UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FGM5_9RHOB Length = 120 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 42/105 (40%), Positives = 62/105 (59%), Gaps = 1/105 (0%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 L ++ +GL+P +VQ + EVLM+ +MN +L+KT E+ TF+SR+++ LW KG TS Sbjct: 8 SLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGLTS 66 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113 GN V + DCD D +L+L P GP CH +CF + Sbjct: 67 GNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTELEEGS 111 >UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C2AA Length = 132 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 41/92 (44%), Positives = 58/92 (63%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 DGL+P IVQ +G VLM+ +M+ AL T+ + + T++SR++ W KG TSG+F Sbjct: 33 NADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWIKGLTSGHFQT 92 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 V S+A DCD DT+L+ G CH G+ SCF Sbjct: 93 VTSLALDCDGDTVLMQVVQDGAACHTGSHSCF 124 >UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms RepID=HIS3_PSEU2 Length = 130 Score = 157 bits (398), Expect = 2e-37, Method: Composition-based stats. Identities = 41/127 (32%), Positives = 67/127 (52%), Gaps = 3/127 (2%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 E+ W +DGL+P I Q +G VLM+ +MN EAL T + ++SR++ +LW KGE Sbjct: 5 LDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGE 63 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125 SG+ + + DCD D ++++ IG CH G SCF ++ ++ +L + Sbjct: 64 ESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYR-VYEKSGWKTVDPVLKDP 122 Query: 126 KSADPET 132 + P Sbjct: 123 DAIYPAG 129 >UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides RepID=Q03VY1_LEUMM Length = 132 Score = 156 bits (396), Expect = 3e-37, Method: Composition-based stats. Identities = 48/118 (40%), Positives = 67/118 (56%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 + + + +GL+P ++ A + LMLGYMN E+ T +G+ F+SR +Q LW KGET Sbjct: 6 PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQELWHKGET 65 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125 SGN VVS+ DCD DTLL+ NP GP CH SCF +T + +A + Sbjct: 66 SGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQATIANK 123 >UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii 'Deep ecotype' RepID=B4RV64_ALTMD Length = 133 Score = 156 bits (394), Expect = 5e-37, Method: Composition-based stats. Identities = 46/103 (44%), Positives = 67/103 (65%), Gaps = 1/103 (0%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 ++ EL+++ DGL+PVI Q S +VLM +M+ E+LD+TL +GK+ ++SR++Q LW Sbjct: 20 DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106 KG +SG+ V SIA DCD D LL + +G CH SCF Sbjct: 79 KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFY 121 >UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae RepID=HIS3_METS3 Length = 132 Score = 156 bits (394), Expect = 5e-37, Method: Composition-based stats. Identities = 43/134 (32%), Positives = 69/134 (51%), Gaps = 9/134 (6%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 R E++ +K + I Q +G++LM+ MN +AL KT+E+GK ++S ++ W K Sbjct: 4 NFRHEINGQKV---ITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLK 60 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH----QWLFLYQLEQ 120 GE+SG+ V I DCD D +++ G CH+G SCF + + LE Sbjct: 61 GESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLET 120 Query: 121 LLAERKSADPETSY 134 +L K +P+ Y Sbjct: 121 ILE--KVFNPDDVY 132 >UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria RepID=HIS3_CHRSD Length = 146 Score = 155 bits (393), Expect = 7e-37, Method: Composition-based stats. Identities = 45/104 (43%), Positives = 62/104 (59%), Gaps = 1/104 (0%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 T W GL+P I Q SGEVLM+ +MN AL++TL +G+V ++SR++ + W Sbjct: 19 TRDLLDAARWNDA-GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106 KGE+SG +V+ DCD DTLL+ + GP CH G SCF Sbjct: 78 RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFY 121 >UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria RepID=HIS3_BACCN Length = 101 Score = 153 bits (387), Expect = 3e-36, Method: Composition-based stats. Identities = 44/98 (44%), Positives = 63/98 (64%), Gaps = 2/98 (2%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ K GL+P IV + + EVLML YMN EA +KTL++ K F+SR++Q LW KG TSG+ Sbjct: 4 NFSK--GLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGH 61 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 +V S+ DCD D +++ N +G CH G +CF Sbjct: 62 VQHVKSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99 >UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria RepID=C7RQA3_9PROT Length = 142 Score = 153 bits (387), Expect = 4e-36, Method: Composition-based stats. Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 1/111 (0%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + EL +++ GL+ I Q + E+LML +MN A+++TL +G ++SR+++ +W K Sbjct: 18 EVLDELAFDQQ-GLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL 115 GETSG V+ DCD D +L+L + +G CH G SSCF + Sbjct: 77 GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRNGRVE 127 >UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms RepID=C7NRL7_HALUD Length = 138 Score = 152 bits (385), Expect = 6e-36, Method: Composition-based stats. Identities = 43/102 (42%), Positives = 59/102 (57%) Query: 19 MPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIA 78 +P + Q A SG+VLML Y+ EALD+T E+G ++SR++ LW KGETSGN ++ I Sbjct: 31 LPAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETSGNVQHLKEIR 90 Query: 79 PDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 DCD D LL + G CH G SCF T + ++ Sbjct: 91 VDCDGDALLYVIEQDGGACHTGFQSCFHRTIDGEVVGERVFD 132 >UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae RepID=HIS3_GLUOX Length = 156 Score = 152 bits (385), Expect = 6e-36, Method: Composition-based stats. Identities = 40/106 (37%), Positives = 65/106 (61%), Gaps = 2/106 (1%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + ++ ++ +GL+ + Q A G VLML +MN +AL +TL +G+V ++SR++Q+L Sbjct: 30 IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107 W KGETSG ++ DCD D +L++ + G CH G SCF Sbjct: 88 WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYH 133 >UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales RepID=HIS3_MYCBP Length = 115 Score = 152 bits (384), Expect = 9e-36, Method: Composition-based stats. Identities = 40/93 (43%), Positives = 60/93 (64%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 DGL+ +VQ SG+VLM+ +MN EAL +TL++ + T++SR++ W KG TSG+ Sbjct: 13 RNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQ 72 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 +V S+ DCD D +L+ + +G CH G SCF Sbjct: 73 HVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCF 105 >UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria RepID=B9QYY7_9RHOB Length = 159 Score = 151 bits (383), Expect = 1e-35, Method: Composition-based stats. Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 4/122 (3%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 DGL+ +V + EVLM+GYMN EAL +T+E+G+ ++SR+++ W KGETSG V Sbjct: 36 DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQIQKVQ 95 Query: 76 SIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDT-AHQWLFLYQLEQLLAERKSADPET 132 I DCD D L+V G TCH G SCF + +L + + K DP+ Sbjct: 96 EILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANV-EKEKVYDPKK 154 Query: 133 SY 134 Y Sbjct: 155 VY 156 >UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales RepID=HIS3_RHISN Length = 152 Score = 151 bits (382), Expect = 1e-35, Method: Composition-based stats. Identities = 46/123 (37%), Positives = 64/123 (52%), Gaps = 3/123 (2%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+ +V A GE+LM+ +MN EAL T+E+G ++SR++ LW KGE+SGN V Sbjct: 29 GLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGNTQAVQE 88 Query: 77 IAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134 I DCD D + + G TCH G SCF T ++ + E + DP Y Sbjct: 89 IRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARV-TITDEHRHFDPAQIY 147 Query: 135 TAK 137 K Sbjct: 148 AEK 150 >UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales RepID=HIS3_ERYLH Length = 125 Score = 150 bits (380), Expect = 2e-35, Method: Composition-based stats. Identities = 47/107 (43%), Positives = 65/107 (60%), Gaps = 4/107 (3%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +DGL+ +VQH + EVLM+ +MN +ALD T ++G FFSR++Q LW KG TSGN L V Sbjct: 21 SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAV 80 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 + DCD D +++L P GP CH G +CF L L+ + Sbjct: 81 SQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE----LDCGALQDV 123 >UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae RepID=HIS3_PYRCJ Length = 128 Score = 150 bits (380), Expect = 3e-35, Method: Composition-based stats. Identities = 39/102 (38%), Positives = 61/102 (59%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 + L++ G + +VQ +GEVLM+G+M+P A+ TL +G ++S +++R+W KGET Sbjct: 17 KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109 SG++ V DCD D +++ IG CH G SCF A Sbjct: 77 SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSPA 118 >UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus ATCC 29799 RepID=A6P0M4_9BACE Length = 108 Score = 150 bits (380), Expect = 3e-35, Method: Composition-based stats. Identities = 50/97 (51%), Positives = 71/97 (73%), Gaps = 1/97 (1%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 ++K++ L+PVI+Q A + EVLMLG+ N EA++ TL++ F+SR++Q+LW KGETSG+F Sbjct: 8 FQKSE-LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHF 66 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 L+V + DCD DTLL +P+GPTCH G SCF Sbjct: 67 LHVERMVTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103 >UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria RepID=HIS3_MESSB Length = 139 Score = 150 bits (379), Expect = 3e-35, Method: Composition-based stats. Identities = 45/96 (46%), Positives = 59/96 (61%), Gaps = 2/96 (2%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GL+ +V A G +LM+ +MN EAL KTLE+G ++SR++ LW KGETSGN +V Sbjct: 30 ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGNLQHV 89 Query: 75 VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDT 108 SI+ DCD D +L V G TCH G SCF Sbjct: 90 ESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRN 125 >UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13 RepID=B6BVA2_9PROT Length = 129 Score = 150 bits (379), Expect = 3e-35, Method: Composition-based stats. Identities = 50/122 (40%), Positives = 76/122 (62%), Gaps = 3/122 (2%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 ++ W GL+P I+Q S +V+M+ +MN EAL KT+E+ + F+SR++ ++W K Sbjct: 2 NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDT-AHQWLFLYQLEQLL 122 GE SGNF NVVSI DCD D+LLV N G +CH G +SCF + + + +E++L Sbjct: 61 GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120 Query: 123 AE 124 + Sbjct: 121 KD 122 >UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ Length = 149 Score = 149 bits (378), Expect = 4e-35, Method: Composition-based stats. Identities = 43/95 (45%), Positives = 58/95 (61%), Gaps = 2/95 (2%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +DGL+P IV A SG VLM +MN +AL +T+ +G F+SR++ +LW KGE SGN L+V Sbjct: 29 SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88 Query: 75 VSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGD 107 + DCD D + +L G CH G SCF Sbjct: 89 KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR 123 >UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPU9_FIBSS Length = 116 Score = 149 bits (376), Expect = 6e-35, Method: Composition-based stats. Identities = 51/116 (43%), Positives = 68/116 (58%), Gaps = 5/116 (4%) Query: 1 MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57 M E +E+ +E G L P IVQ A G+VLM+ +MN EAL +T E G++ F+SR+ Sbjct: 1 MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60 Query: 58 KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111 ++ W KG+TSGN + VV A DCD+D LL GP CH G SCF T + Sbjct: 61 RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116 >UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G191_ABIDE Length = 295 Score = 149 bits (376), Expect = 7e-35, Method: Composition-based stats. Identities = 48/102 (47%), Positives = 64/102 (62%), Gaps = 1/102 (0%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ ++ GL+P IVQ +G VL + YMN E+L+ TL F+SR+++ LW KGE Sbjct: 18 IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 TSGN+ +VVSI DCD D LLV G CH+G SCF DT Sbjct: 77 TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDT 118 >UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R0N1_9RHOB Length = 156 Score = 148 bits (375), Expect = 8e-35, Method: Composition-based stats. Identities = 47/138 (34%), Positives = 69/138 (50%), Gaps = 5/138 (3%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L ++ + D +GL+ V SGE+LM+GYMN E+L +T+E+G+ ++SR++Q Sbjct: 21 LGDELCPKFD---ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEY 77 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119 W KG TSG V+ I DCD D + V + G TCH G SCF + Sbjct: 78 WKKGGTSGQVQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWL 137 Query: 120 QLLAERKSADPETSYTAK 137 + DP+ Y K Sbjct: 138 EKTEVAPVYDPQEVYGKK 155 >UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41B27 Length = 137 Score = 148 bits (375), Expect = 9e-35, Method: Composition-based stats. Identities = 40/119 (33%), Positives = 66/119 (55%), Gaps = 3/119 (2%) Query: 9 ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 EL++ G L+ + Q + +VLM+ +MN EA+++TL++ K ++S ++Q+ W KG Sbjct: 2 ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 E+SGN V + DCD D +++ + IG CH+G SCF L+ L E Sbjct: 62 ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDE 120 >UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI Length = 161 Score = 148 bits (373), Expect = 2e-34, Method: Composition-based stats. Identities = 48/128 (37%), Positives = 69/128 (53%), Gaps = 7/128 (5%) Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75 +GL+PV+ A +GEVLM YMN EAL KT+E+G+ ++SR++Q+LW KG++SG V Sbjct: 27 NGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGLVQKVQ 86 Query: 76 SIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQW-LFLYQLEQL----LAERKSA 128 +A D D D L + G +CH G SCF + E + K+ Sbjct: 87 QLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTETEKTF 146 Query: 129 DPETSYTA 136 DP+T Y Sbjct: 147 DPKTVYGN 154 >UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter necessarius RepID=B1XSV4_POLNS Length = 140 Score = 147 bits (372), Expect = 2e-34, Method: Composition-based stats. Identities = 42/101 (41%), Positives = 60/101 (59%), Gaps = 2/101 (1%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 + W GL+PVI Q S ++LM+ +MN +AL +TL G+ +++R++Q+LW KGE Sbjct: 23 LDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHKGE 81 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106 SG+ V I DCD DT+L+L G CH G SCF Sbjct: 82 ESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122 >UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1 RepID=A3WCC9_9SPHN Length = 143 Score = 145 bits (367), Expect = 7e-34, Method: Composition-based stats. Identities = 47/94 (50%), Positives = 63/94 (67%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 GL+ +V + + EVL++ +MN +AL KT E+GKV F+SR++ LW KGETSGN L+V Sbjct: 35 ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGNVLSV 94 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 I DCD D L++ A P GPTCH G +SCF Sbjct: 95 DEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128 >UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris BL2 RepID=B8EQR3_METSB Length = 141 Score = 144 bits (365), Expect = 1e-33, Method: Composition-based stats. Identities = 42/95 (44%), Positives = 55/95 (57%), Gaps = 2/95 (2%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+ + + A GE+LM+ YMN EAL TL +G+ ++SR++Q +W KG TSG V Sbjct: 30 PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89 Query: 75 VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGD 107 I DCD D LL + A G CH G SCF Sbjct: 90 REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYR 124 >UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae RepID=HIS3_ZYMMO Length = 124 Score = 143 bits (361), Expect = 3e-33, Method: Composition-based stats. Identities = 36/100 (36%), Positives = 61/100 (61%), Gaps = 1/100 (1%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 W+ GL+ ++ A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ Sbjct: 15 WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111 + + I DCD DTL + P+GP CH G SCF Sbjct: 74 MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVED 113 >UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001910D6A Length = 157 Score = 141 bits (355), Expect = 2e-32, Method: Composition-based stats. Identities = 74/81 (91%), Positives = 77/81 (95%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR Sbjct: 77 MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136 Query: 61 LWTKGETSGNFLNVVSIAPDC 81 LWTKGETSG+ LNVVSIAPDC Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157 >UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001744401 Length = 141 Score = 141 bits (355), Expect = 2e-32, Method: Composition-based stats. Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 1/97 (1%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P I + E LM+ YMN E L T+ G+ ++SR+++ +W KG+TSG F V Sbjct: 31 ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGEFQVV 90 Query: 75 VSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAH 110 I DCD D +++ +G CH +CF Sbjct: 91 KEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRKVD 127 >UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT Length = 127 Score = 140 bits (353), Expect = 3e-32, Method: Composition-based stats. Identities = 45/130 (34%), Positives = 67/130 (51%), Gaps = 5/130 (3%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 Q +L + GL+P ++ A G+ L L YMN +A+ KT+E+GK+ F R++ RL K Sbjct: 2 QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 GETSG+ +V I DC+ ++L+ + CH G SC+ Q + E Sbjct: 61 GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQTNSIQ----VVE 116 Query: 125 RKSADPETSY 134 K DPE Y Sbjct: 117 EKVFDPENVY 126 >UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF76_THET1 Length = 300 Score = 138 bits (347), Expect = 1e-31, Method: Composition-based stats. Identities = 42/92 (45%), Positives = 66/92 (71%), Gaps = 1/92 (1%) Query: 17 GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76 GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W KGETSG L+V Sbjct: 20 GLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLKGETSGRTLHVRE 79 Query: 77 IAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD 107 + P+C+ ++LL+L + P CH G SCF Sbjct: 80 LRPNCELNSLLILVDQRLPGACHTGHFSCFYR 111 >UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZDC3_9SPHI Length = 130 Score = 134 bits (337), Expect = 2e-30, Method: Composition-based stats. Identities = 47/112 (41%), Positives = 63/112 (56%), Gaps = 7/112 (6%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 +EK GL+PV+VQ SG+VLMLGY N AL +TL++G TF+S ++ LWTKG+TSG++ Sbjct: 15 FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74 Query: 72 LNVVSIAPDCDNDTLLVLANPIGP-TCHK------GTSSCFGDTAHQWLFLY 116 L + I DCD D L+ +G CH SCF L Sbjct: 75 LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCFYRKMASGKTLE 126 >UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HIS3_IGNH4 Length = 129 Score = 133 bits (336), Expect = 3e-30, Method: Composition-based stats. Identities = 36/99 (36%), Positives = 57/99 (57%), Gaps = 1/99 (1%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 L++ D + + Q SG+VLM+ MN EA+ KTL +G V ++S++++ LW KG T Sbjct: 14 ERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGAT 73 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCF 105 SG+ + DCD D++L++ CH+G SCF Sbjct: 74 SGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCF 112 >UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58 RepID=Q1NG03_9SPHN Length = 157 Score = 132 bits (332), Expect = 9e-30, Method: Composition-based stats. Identities = 42/104 (40%), Positives = 58/104 (55%), Gaps = 1/104 (0%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +GLMP IV +A VLMLGYMN EAL +TL + + F+SR+++ LW KGE SG V Sbjct: 25 AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGFRQRV 84 Query: 75 VSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQ 117 + D D D L+++ P +CH G SCF + + Sbjct: 85 DHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDK 128 >UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales RepID=HIS3_METVS Length = 136 Score = 131 bits (331), Expect = 1e-29, Method: Composition-based stats. Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%) Query: 6 QRRELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 Q +L + K D L+ I VLM +M+ E+L TL++G + +FS ++ ++W Sbjct: 17 QNMDLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWM 75 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH 110 KGE S N V+ + DCD D LL + G CH+G SCF + Sbjct: 76 KGEESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNKVD 122 >UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira RepID=HIS3_LEPIN Length = 187 Score = 129 bits (325), Expect = 5e-29, Method: Composition-based stats. Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 9/117 (7%) Query: 10 LDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 LD++KT L+PV+ + G++LM + N E+ +L++G +FSR++ +L Sbjct: 61 LDFQKTTELLLTGKKNLVPVVAID-LQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQL 119 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118 W KG+TSG+ ++ I D L+ CH+G SCF + + L Sbjct: 120 WKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERMEGVTWKLL 176 >UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SQK1_VERA1 Length = 699 Score = 129 bits (324), Expect = 7e-29, Method: Composition-based stats. Identities = 41/137 (29%), Positives = 66/137 (48%), Gaps = 14/137 (10%) Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132 ++ ++ DCDND + + G CH CFG+ + +LE+ L RK + PE Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNLTG----IARLEKTLKARKESAPEG 221 Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192 SYTA+L+ + K + K+ EE E A T D + EA+DL+Y L G+ + Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDAKTKED---VAFEAADLIYFALTKAVSAGVSVA 277 Query: 193 TVIENLR------KRHQ 203 + ++L KR + Sbjct: 278 DIEKSLDAKGWKVKRRK 294 >UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms RepID=HIS2_PELTS Length = 98 Score = 128 bits (323), Expect = 9e-29, Method: Composition-based stats. Identities = 34/94 (36%), Positives = 50/94 (53%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 + + L +++ +R+ P+ SYTA L+ G +I +K+GEE E +AA L Sbjct: 2 GEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAAL 61 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E +DL+YHLLVLL GL V+ L R Q Sbjct: 62 VGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95 >UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria RepID=HIS2_LEPBJ Length = 92 Score = 126 bits (317), Expect = 4e-28, Method: Composition-based stats. Identities = 48/89 (53%), Positives = 61/89 (68%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 FL QLE +L +RK P+ SYTA L+ G RI +KVGEE E +AA D+ ELT+EA Sbjct: 3 FLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEA 62 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL++HL VLL +Q L L V+E LRKRH Sbjct: 63 ADLLFHLQVLLVEQELSLQDVVEELRKRH 91 >UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria RepID=HIS2_CLOB1 Length = 110 Score = 126 bits (316), Expect = 7e-28, Method: Composition-based stats. Identities = 32/94 (34%), Positives = 51/94 (54%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 ++ + L ++ +RK E SYT L+ G +I +KVGEE E +AA D EL Sbjct: 2 NRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEEL 61 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E DL YH++VL+ ++ + L + + L KR + Sbjct: 62 IKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95 >UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5 Length = 105 Score = 124 bits (313), Expect = 1e-27, Method: Composition-based stats. Identities = 29/90 (32%), Positives = 51/90 (56%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + +L ++ +RK + SYT L+ G +I +KVGEE E +A+ ++ + E Sbjct: 1 MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 DL+YH+LVL+ ++ + L + + L KR Q Sbjct: 61 CDLIYHVLVLMANENITLEELRKELEKRRQ 90 >UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium RepID=HIS2_CLONN Length = 110 Score = 124 bits (312), Expect = 2e-27, Method: Composition-based stats. Identities = 29/94 (30%), Positives = 51/94 (54%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 + +L ++ +RK E SYT L+ G +I +KVGEE E +AA ++ +L Sbjct: 2 DNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDDL 61 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E D++YH++VL+ ++ + L + L KR + Sbjct: 62 IAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95 >UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae RepID=HIS3_SULSO Length = 85 Score = 124 bits (311), Expect = 2e-27, Method: Composition-based stats. Identities = 35/76 (46%), Positives = 48/76 (63%) Query: 33 MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92 M+G MN EAL KTL +G + F+S ++++LW KGETSGNF + DCD D +L Sbjct: 1 MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60 Query: 93 IGPTCHKGTSSCFGDT 108 +GP CH G +CF + Sbjct: 61 LGPICHTGNYTCFYRS 76 >UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes RepID=HIS2_BACC2 Length = 107 Score = 123 bits (310), Expect = 3e-27, Method: Composition-based stats. Identities = 28/85 (32%), Positives = 49/85 (57%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + + ERK + SYT L++ G +I +K+GEE E +A +D+ E+ E D+ Sbjct: 8 LYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVF 67 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202 YH VLL ++ + L V+ +++R+ Sbjct: 68 YHCFVLLAEKNIALEDVMREVKERN 92 >UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria RepID=A6LT24_CLOB8 Length = 108 Score = 123 bits (310), Expect = 3e-27, Method: Composition-based stats. Identities = 32/89 (35%), Positives = 48/89 (53%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + L + + +RK+ E SYT L+ GT +I +KVGEE E ++ +++ E NE Sbjct: 4 NIKALYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINEI 63 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 DL YHLLVL+ + + V L KR Sbjct: 64 CDLTYHLLVLMAQMNISIEEVGAELEKRR 92 >UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SHA6_LEPBA Length = 202 Score = 123 bits (310), Expect = 3e-27, Method: Composition-based stats. Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 1/103 (0%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L P + Q ++G+ LML + E+L +ESG T+FSR++ W KGE SG+F + I Sbjct: 94 LSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQI 152 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 + + + + IG CH G SCF Q + + Sbjct: 153 YVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYS 195 >UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria RepID=HIS2_MAGSA Length = 109 Score = 121 bits (305), Expect = 1e-26, Method: Composition-based stats. Identities = 42/91 (46%), Positives = 56/91 (61%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L +L ++A RK DP+ SYTAKL+A G +IAQK GEE VET +AA + EL Sbjct: 4 DSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDELV 63 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E++D +YHLLVL D G++ V L +R Sbjct: 64 GESADTLYHLLVLWADCGVEPAKVWAELARR 94 >UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria RepID=HIS2_NITMU Length = 121 Score = 121 bits (304), Expect = 1e-26, Method: Composition-based stats. Identities = 34/92 (36%), Positives = 49/92 (53%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L++L + + RK +DP SY AKL G +I +K+ EE E LA+ D + Sbjct: 3 DPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVV 62 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 E +DL +H LVLL L L V++ LR+R Sbjct: 63 RETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94 >UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KWI3_HALNC Length = 124 Score = 120 bits (302), Expect = 2e-26, Method: Composition-based stats. Identities = 44/94 (46%), Positives = 60/94 (63%) Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167 T + L QL ++ +RK ADP +SY A+L+A G +IAQKVGEEGVE ALAA D Sbjct: 3 TNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDNV 62 Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + +E +DL +H +VLL D GL V++ L +R Sbjct: 63 AIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96 >UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria RepID=HIS2_ACICJ Length = 133 Score = 120 bits (302), Expect = 2e-26, Method: Composition-based stats. Identities = 34/96 (35%), Positives = 53/96 (55%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 A L +L + RK+ADP S++A+L + G ++AQK GEE VE + A +R Sbjct: 14 PAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNR 73 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E++D++YHLLV+ G+ V L++R Sbjct: 74 TALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109 >UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZNB1_9GAMM Length = 125 Score = 120 bits (302), Expect = 3e-26, Method: Composition-based stats. Identities = 34/97 (35%), Positives = 53/97 (54%) Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 D L L +++ +R+ ADPE SY AKL+A G + +K+GEE ET +A Sbjct: 5 ASDARAGAELLSALAEVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKND 64 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 D L +E +DL +H L++L +G V++ L +R Sbjct: 65 DSDALVSEMADLWFHSLIVLAARGRHPDDVLDELARR 101 >UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria RepID=HIS2_GRABC Length = 160 Score = 120 bits (301), Expect = 4e-26, Method: Composition-based stats. Identities = 35/96 (36%), Positives = 56/96 (58%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 D + L +L +++ +R+ ADP S++A+L + G ++AQK GEE VE + A D+ Sbjct: 38 DPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E++D++YHLLVL G++ V L KR Sbjct: 98 EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133 >UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum ATCC 11170 RepID=HIS2_RHORT Length = 117 Score = 119 bits (300), Expect = 5e-26, Method: Composition-based stats. Identities = 36/88 (40%), Positives = 52/88 (59%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + L ++A R+ ADP TSYTAKL+ G +I QK GEE E +AA V ++ E+ Sbjct: 16 IIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAES 75 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +D++YHL+VL D G+ V L +R Sbjct: 76 ADVLYHLMVLWADVGVTPDRVWAELARR 103 >UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=B0MMD1_9FIRM Length = 114 Score = 118 bits (297), Expect = 1e-25, Method: Composition-based stats. Identities = 37/98 (37%), Positives = 58/98 (59%), Gaps = 5/98 (5%) Query: 111 QWLFLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165 + ++ +++ RK+ PE SYT L+ G +I +KVGEE ET +AA D Sbjct: 2 KMTVYEEIFEVIKARKAQYDAGNAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNAD 61 Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EL NE +DL+YH++VL D+GL+ + V E L +R++ Sbjct: 62 NDELKNEINDLLYHVMVLCADRGLEWSEVEEVLSERNE 99 >UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria RepID=HIS2_ACIAC Length = 137 Score = 118 bits (297), Expect = 1e-25, Method: Composition-based stats. Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 7/112 (6%) Query: 98 HKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD---PETSYTAKLYASGTKRIAQKVGEEG 154 H S H L +L ++ RK A+ + SY A+L G +K+GEE Sbjct: 3 HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62 Query: 155 VETALAATV----HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 E +AA D +L E +DL +H ++ L GL V+ L +R Sbjct: 63 TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114 >UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms RepID=HIS2_ALHEH Length = 109 Score = 118 bits (297), Expect = 1e-25, Method: Composition-based stats. Identities = 36/93 (38%), Positives = 51/93 (54%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + Q L L ++L ER+ ADP TSY AKL+ G I +KVGEE E +AA DR + Sbjct: 2 SEQRDILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQ 61 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + E +DL +H L++L V+ L +R Sbjct: 62 VIYETADLWFHSLIMLSACDAGPDDVLAELERR 94 >UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM 10642 RepID=C8SBH0_FERPL Length = 92 Score = 118 bits (296), Expect = 1e-25, Method: Composition-based stats. Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 L +L++++ ERK SYTAKL G ++ +K GEE VE LA D+ + Sbjct: 1 MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EA+DL+YH +VLL + + V + LR+R + Sbjct: 61 EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92 >UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei group RepID=HIS2_LACCB Length = 110 Score = 118 bits (296), Expect = 1e-25, Method: Composition-based stats. Identities = 29/88 (32%), Positives = 45/88 (51%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 + L + ER++ SYT L+ G +I +KVGEE E +AA D E + Sbjct: 8 IPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPAFILEVA 67 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRH 202 DL YH+LVL+ ++G+ + + L R Sbjct: 68 DLTYHVLVLMVERGITVDQIATELASRE 95 >UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD Length = 101 Score = 118 bits (295), Expect = 2e-25, Method: Composition-based stats. Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 2/95 (2%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 E + L+PV+V SG++LML Y + L+ T +G ++SR++Q +W KG +SG Sbjct: 2 ETSTKLLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQ 61 Query: 73 NVVSIAPDCDNDTL--LVLANPIGPTCHKGTSSCF 105 V ++ DCD D L VL G CH SCF Sbjct: 62 LVQAVYRDCDGDALNFRVLVLGDGRVCHTRQVSCF 96 >UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria RepID=HIS2_HALHL Length = 114 Score = 117 bits (294), Expect = 2e-25, Method: Composition-based stats. Identities = 31/97 (31%), Positives = 50/97 (51%) Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 L L + + +R+ A +TSY A+L+ G I +KVGEE E +AA Sbjct: 4 AASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGG 63 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +R ++ E +DL +H LV+L G+ + V+ L +R Sbjct: 64 EREQVVYETADLWFHTLVMLSASGVSVDEVLAELERR 100 >UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic archaeon RC-I RepID=HIS2_UNCMA Length = 95 Score = 117 bits (293), Expect = 3e-25, Method: Composition-based stats. Identities = 28/94 (29%), Positives = 48/94 (51%), Gaps = 2/94 (2%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFEL 169 L ++ ++A+RK E SYT LY G ++ +K+GEE E +AA E+ Sbjct: 2 ADVLDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEI 61 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +E +DL +H +VLL + + + E +R + Sbjct: 62 VSECADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95 >UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSK8_9BACT Length = 125 Score = 116 bits (290), Expect = 5e-25, Method: Composition-based stats. Identities = 47/103 (45%), Positives = 59/103 (57%), Gaps = 7/103 (6%) Query: 10 LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 +D + + L+ V V M GYMN A++ TL G VTFFSRT +LW Sbjct: 20 VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79 Query: 64 KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 KGETSGN L + I DCD D+LL+ A P+G TCH G+ SCF Sbjct: 80 KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCF 122 >UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria RepID=HIS2_MAGSM Length = 252 Score = 116 bits (290), Expect = 6e-25, Method: Composition-based stats. Identities = 38/97 (39%), Positives = 51/97 (52%), Gaps = 2/97 (2%) Query: 107 DTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVGEEGVETALAATVH- 164 L Q+ Q++ +RKSA PE SY AKL+ G I +KVGEE E LA Sbjct: 5 SPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKGRA 64 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 R E+ +EA+DL++H LV L + T V+ L R Sbjct: 65 ARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101 >UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae RepID=HIS2_METBF Length = 104 Score = 115 bits (289), Expect = 8e-25, Method: Composition-based stats. Identities = 33/98 (33%), Positives = 52/98 (53%), Gaps = 2/98 (2%) Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHD 165 L ++ +++ +RK E SY KL G +I +KVGEE +ET LA + Sbjct: 2 PDADLSILNRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEN 61 Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E+ +E+SDL++HLLV+L + L + L RH+ Sbjct: 62 HEEIVSESSDLIFHLLVMLAANNVTLDEIAAELSARHE 99 >UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei RepID=HIS2_IGNH4 Length = 102 Score = 115 bits (289), Expect = 9e-25, Method: Composition-based stats. Identities = 34/92 (36%), Positives = 54/92 (58%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 FL +L ++ +R P+ SYTA++ G A+K GEE VE +A+ R + Sbjct: 2 SDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIY 61 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EA+D++YHL+VLL +G+D VI+ L +R + Sbjct: 62 EAADVIYHLMVLLALRGVDWAEVIKELERRSR 93 >UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales RepID=HIS2_BORA1 Length = 116 Score = 114 bits (286), Expect = 2e-24, Method: Composition-based stats. Identities = 30/98 (30%), Positives = 43/98 (43%), Gaps = 3/98 (3%) Query: 108 TAHQWLFLYQLEQLLAERKSAD---PETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 L ++ L R + P+TSY AKL A G +K+GEE E +AA Sbjct: 5 PVFGADVLARVADTLETRLPQNGGDPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDG 64 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + +E +DL +H LV L L V+ L +R Sbjct: 65 RPERIVSETADLWFHCLVTLAHYNLRPEDVLAELARRE 102 >UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria RepID=HIS2_NEIG1 Length = 107 Score = 114 bits (286), Expect = 2e-24, Method: Composition-based stats. Identities = 32/90 (35%), Positives = 48/90 (53%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L ++Q + +RKSADP SY A+L G +I +KV EE E +A+ D L E Sbjct: 4 SVLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHLVYE 63 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL +H ++LL L V++ L +R Sbjct: 64 VADLWFHTMILLTHHDLKAEDVLDELSRRQ 93 >UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria RepID=HIS2_BRUA1 Length = 107 Score = 114 bits (286), Expect = 2e-24, Method: Composition-based stats. Identities = 40/91 (43%), Positives = 57/91 (62%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L LE+++AER S TSYTA L A G + AQK+GEE VET +AA DR + Sbjct: 2 SQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVV 61 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +E++DL+YHL V+ G+ L V++ L++R Sbjct: 62 SESADLLYHLAVVWNIAGVALEDVLQELQRR 92 >UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales RepID=HIS2_METB6 Length = 104 Score = 114 bits (285), Expect = 2e-24, Method: Composition-based stats. Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 2/100 (2%) Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATV 163 G + +L ++ ER E SYT++L G ++ +KVGEE E LA Sbjct: 5 GKEPVDLRVIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEESTEFILAVKN 64 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 T EA+DL +H+LV L+ +DL+ VI L +R + Sbjct: 65 GVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104 >UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta proteobacterium KB13 RepID=B6BVA1_9PROT Length = 104 Score = 114 bits (285), Expect = 2e-24, Method: Composition-based stats. Identities = 36/90 (40%), Positives = 59/90 (65%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 L +L+QL+ +K +DP SYTAKL++ G + I +K GEE +E +A+ ++ + N Sbjct: 1 MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E++D++YHLLVLL ++ + L VI L +R Sbjct: 61 ESADVLYHLLVLLSEKSVTLKEVISELERR 90 >UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria RepID=HIS2_BURCC Length = 121 Score = 114 bits (285), Expect = 2e-24, Method: Composition-based stats. Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%) Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV---- 163 T L +L ++ RK DP+ SY ++L+ G + +K+GEE E LAA Sbjct: 2 TQSTEDTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQG 61 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E +DL +H LV+L L VI L +R Sbjct: 62 GAPTALVGEVADLWFHCLVMLSHFDLSPADVIAELERRE 100 >UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales RepID=HIS2_LEUMM Length = 114 Score = 113 bits (283), Expect = 4e-24, Method: Composition-based stats. Identities = 34/91 (37%), Positives = 49/91 (53%), Gaps = 1/91 (1%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 + +L + ERK SYT LY G +I +KVGEE E L A ++ EL Sbjct: 2 PQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EELI 60 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E SDL++HL+VLL ++G+ L + + L R Sbjct: 61 YETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91 >UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1 Tax=Raoultella terrigena RepID=Q6U8A9_KLETE Length = 88 Score = 112 bits (281), Expect = 7e-24, Method: Composition-based stats. Identities = 71/85 (83%), Positives = 75/85 (88%) Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMY Sbjct: 4 AGLLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMY 63 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 HL+VLLQDQ L L +I NL+ RHQ Sbjct: 64 HLMVLLQDQELSLQDIIANLKSRHQ 88 >UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis RepID=HIS2_ZYMMO Length = 107 Score = 111 bits (279), Expect = 1e-23, Method: Composition-based stats. Identities = 43/89 (48%), Positives = 57/89 (64%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +E ++AER+ A PE SY + L+ GT IAQKVGEE VET +AA D+ L +EA Sbjct: 5 TLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSLESEA 64 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL++HL VLL D+G V LR+R Sbjct: 65 ADLIFHLAVLLADRGSSFENVFSELRRRE 93 >UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria RepID=HIS2_NITWN Length = 116 Score = 111 bits (278), Expect = 2e-23, Method: Composition-based stats. Identities = 36/91 (39%), Positives = 51/91 (56%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 Q ++ L ++ R ++ + SYT KL G A+K+GEE VET +AA DR L Sbjct: 11 QRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKDRHHLI 70 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +DLM+H LVLL+ G+ L V L +R Sbjct: 71 AEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101 >UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae RepID=HIS2_NATPD Length = 101 Score = 111 bits (277), Expect = 2e-23, Method: Composition-based stats. Identities = 39/99 (39%), Positives = 56/99 (56%), Gaps = 2/99 (2%) Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATV 163 GD L +L +++ RK P+ SYTA L+ G + +K+GEE E LAA Sbjct: 3 GDGHDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKD 62 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 D EL +EA+D++YHLLVLL + ++L + LRKR Sbjct: 63 DDDEELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101 >UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales RepID=HIS2_MESSB Length = 112 Score = 111 bits (277), Expect = 2e-23, Method: Composition-based stats. Identities = 36/91 (39%), Positives = 57/91 (62%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L +LE ++AER ++ S+TA+L ++G + A+K+GEE VET +AA D+ L Sbjct: 2 NEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKALI 61 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E++DL+YH LV+L+ G+ L V+ L R Sbjct: 62 AESADLVYHWLVVLKIAGVRLDEVMLELESR 92 >UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ Length = 127 Score = 110 bits (276), Expect = 2e-23, Method: Composition-based stats. Identities = 37/95 (38%), Positives = 53/95 (55%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 + L +L L+ R+S + SYTA+L +G +R A+K GEE VET +AA D Sbjct: 16 EFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSDA 75 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 L EA+D +YHLLVLL+ + + V+ L R Sbjct: 76 SALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110 >UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing symbionts RepID=HIS2_VESOH Length = 105 Score = 110 bits (275), Expect = 4e-23, Method: Composition-based stats. Identities = 30/85 (35%), Positives = 48/85 (56%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +LEQ+L +RKSA + SY + LY GT I +K+ EE E +A ++ E +DL Sbjct: 7 KLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEIADL 66 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201 +H LVLL+ + + + + L +R Sbjct: 67 WFHTLVLLRFKKIKVEQITNELSRR 91 >UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SM22_9BACT Length = 100 Score = 109 bits (274), Expect = 4e-23, Method: Composition-based stats. Identities = 28/88 (31%), Positives = 51/88 (57%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + +L +++ ERK+ + SYT +L G+ +I +K+GEE E A D ++ E Sbjct: 5 IIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDVAGET 64 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +DL+YHL+V L+ + + V+ L++R Sbjct: 65 ADLLYHLIVALEFRNVQFEDVLGVLQER 92 >UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ9_9ACTN Length = 105 Score = 108 bits (271), Expect = 9e-23, Method: Composition-based stats. Identities = 31/103 (30%), Positives = 49/103 (47%) Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159 G + + L L +++ R+ A P+ SYTA+L + +K+ EE E + Sbjct: 2 GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61 Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 A +D + EA DL+YHLLV L+ G+ L + L R Sbjct: 62 ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARR 104 >UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FUB9_METHJ Length = 91 Score = 108 bits (271), Expect = 9e-23, Method: Composition-based stats. Identities = 25/90 (27%), Positives = 51/90 (56%), Gaps = 2/90 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + ++ ++ ER + E SYT+K+ + G + +K+GEE E +A D+ ++ E Sbjct: 1 MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL++H ++ L+ G+ L +V + L+ R Sbjct: 61 GADLLFHFMLALKRSGVTLQSVWDELQSRR 90 >UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae RepID=Q2CDY7_9RHOB Length = 106 Score = 107 bits (268), Expect = 2e-22, Method: Composition-based stats. Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 1/89 (1%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + L L + +A RK ADP+ S+TA+L AS + A+K GEE VE + A DR L +E Sbjct: 1 MSLAALAETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSE 59 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 A+D++YHLLV+ + L + L +R Sbjct: 60 AADVIYHLLVMCAVNDITLADIERELERR 88 >UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae RepID=A4SV22_POLSQ Length = 133 Score = 105 bits (263), Expect = 9e-22, Method: Composition-based stats. Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 14/101 (13%) Query: 115 LYQLEQLLAERK------SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV----- 163 L L ++ +R+ SADP+TSYTA L++ G I +K+GEE E +AA Sbjct: 15 LAHLADVVDQRRDAFKAGSADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSN 74 Query: 164 ---HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + L E +DL +H L+ L L VI L +R Sbjct: 75 LAAEQQKLLIGEMADLWFHCLIALSQFNLRPEDVIAELDRR 115 >UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis RepID=HIS2_SPHAL Length = 109 Score = 104 bits (260), Expect = 2e-21, Method: Composition-based stats. Identities = 39/90 (43%), Positives = 54/90 (60%), Gaps = 1/90 (1%) Query: 114 FLYQLEQLLAERKSADP-ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L +LE ++ +R +A E SY A L A G +IAQK+GEE VE +AA D L E Sbjct: 8 TLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGE 67 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 ASDL++HL +LL ++GL + L +RH Sbjct: 68 ASDLVFHLSILLAERGLTWDAIAAELDRRH 97 >UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae RepID=HIS22_BRAJA Length = 134 Score = 104 bits (259), Expect = 2e-21, Method: Composition-based stats. Identities = 27/88 (30%), Positives = 46/88 (52%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L +L + + DP TS TA+L+ G ++A+K+ EE +E + A D + E++ Sbjct: 5 LERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRESA 64 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRH 202 DL+Y+L VL G+ V + +R Sbjct: 65 DLLYNLTVLWASAGVRPEDVWREMTRRE 92 >UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TJZ9_9PROT Length = 104 Score = 104 bits (259), Expect = 2e-21, Method: Composition-based stats. Identities = 30/89 (33%), Positives = 50/89 (56%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 + +L + + ++ P S TA+L G +IA+KV EE E AL A V DR + E++ Sbjct: 5 IDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRESA 64 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 DL+Y+L+VL G+ + V + +R + Sbjct: 65 DLLYNLMVLWVWMGITPSEVWAEMEQREK 93 >UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota RepID=HIS2_META3 Length = 96 Score = 102 bits (254), Expect = 8e-21, Method: Composition-based stats. Identities = 32/89 (35%), Positives = 52/89 (58%), Gaps = 4/89 (4%) Query: 119 EQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 +++ +R PE SY A L + +I +KVGEE ET LAA D+ EL E++ Sbjct: 8 FEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESA 67 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 DL++H+LVLL + G++ ++E +R + Sbjct: 68 DLIFHILVLLANNGIEYEELMEEFERRRK 96 >UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VQS9_9PROT Length = 109 Score = 102 bits (254), Expect = 1e-20, Method: Composition-based stats. Identities = 38/90 (42%), Positives = 48/90 (53%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L +L + RK AD SYTA L G R A+K GEE VE ALA + R +L E Sbjct: 6 ATLERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAE 65 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +D++YHL VLL LD + + L KR Sbjct: 66 TADVLYHLAVLLAANELDWSDISAALTKRE 95 >UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani RepID=HIS2_CLOTE Length = 107 Score = 100 bits (249), Expect = 3e-20, Method: Composition-based stats. Identities = 29/88 (32%), Positives = 51/88 (57%), Gaps = 4/88 (4%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 + +L +++ +RK D SY L+ + +I +K+GE+ E +A + E +E S Sbjct: 7 IEELVEVIKDRK-NDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEIS 62 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRH 202 DL+Y+L+VL+ Q +++ VIE L KR Sbjct: 63 DLIYNLMVLMMKQNIEIENVIEELGKRR 90 >UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K RepID=B4UDK1_ANASK Length = 110 Score = 96.4 bits (239), Expect = 4e-19, Method: Composition-based stats. Identities = 35/98 (35%), Positives = 47/98 (47%), Gaps = 7/98 (7%) Query: 111 QWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVH 164 FL +L + R+ A P SYT KL A+ RI +K+ EE E A Sbjct: 3 DERFLAKLWATIESRRADAAPAESYTKKLLAA-PARIRRKIIEEAYEVNEAHQALLDGKD 61 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + L +EA+DL+YHL VLL + T V L +RH Sbjct: 62 TKDHLAHEAADLLYHLYVLLASADVTPTEVYGVLERRH 99 >UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp. HTCC2601 RepID=Q0FX88_9RHOB Length = 164 Score = 95.3 bits (236), Expect = 1e-18, Method: Composition-based stats. Identities = 30/67 (44%), Positives = 40/67 (59%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGLMP A SGE+LMLG+M EA T+E+G+ +FSR +Q LW +G SG L + Sbjct: 12 PDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKL 71 Query: 75 VSIAPDC 81 V + Sbjct: 72 VEARIED 78 >UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB Length = 101 Score = 94.9 bits (235), Expect = 2e-18, Method: Composition-based stats. Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 2/86 (2%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + +RK+ D + SYT+ L + G + K+ EE E A +D+ + +EA+D + Sbjct: 8 LVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHEAADTI 65 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRHQ 203 YH+LV L+ + V++ L R + Sbjct: 66 YHILVTLEAADIKFEDVLKELEGRKK 91 >UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium RepID=C4L178_EXISA Length = 102 Score = 91.0 bits (225), Expect = 2e-17, Method: Composition-based stats. Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 +++LEQL+ RK E SYT L+ G ++IA+K GEE E +AA +L E+ Sbjct: 1 MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL+YHLLVLL +G+ L V L KRH Sbjct: 59 ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87 >UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae RepID=Q0C645_HYPNA Length = 120 Score = 90.7 bits (224), Expect = 2e-17, Method: Composition-based stats. Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 1/84 (1%) Query: 120 QLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 + + R D +S+TAKL A G A KV EEG E A A + +EA+D++Y Sbjct: 22 ETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELADAVRRESDDRVASEAADVIY 81 Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202 H+ V L+ +G+ L V L R Sbjct: 82 HVFVALRSRGVALDAVAGALEARQ 105 >UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD Length = 253 Score = 90.7 bits (224), Expect = 3e-17, Method: Composition-based stats. Identities = 30/80 (37%), Positives = 50/80 (62%) Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 ++ + +S + S+T K+ A G +I +KVGEE VE LA D + +EA+D++YH+ Sbjct: 56 IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115 Query: 181 LVLLQDQGLDLTTVIENLRK 200 L+LL GL L T+ + +R+ Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135 >UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae RepID=HIS2_METS5 Length = 93 Score = 90.3 bits (223), Expect = 4e-17, Method: Composition-based stats. Identities = 38/90 (42%), Positives = 55/90 (61%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +L ++A+R PE SYTA L G +A+KVGEE VE +A+ R + +E Sbjct: 4 VLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSET 63 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +DL+YHLLVLL +G+ L V + LR+R + Sbjct: 64 ADLIYHLLVLLAMEGISLDEVRDELRRRMK 93 >UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae RepID=HIS2_METS3 Length = 96 Score = 86.8 bits (214), Expect = 4e-16, Method: Composition-based stats. Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 7/93 (7%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLY----ASGTKRIAQKVGEEGVETALAATVHDRFEL 169 + ++ ++L ER+ P SYT+K+ +I +KV EE E LAA L Sbjct: 6 IIREVYKVLEERRDN-PIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND--ENL 62 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 E+ DL++H L++L +G+++ + E +R Sbjct: 63 VYESVDLIFHTLLILVYKGIEIDEIFEEFARRR 95 >UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales RepID=Q0F926_9RHOB Length = 105 Score = 85.3 bits (210), Expect = 1e-15, Method: Composition-based stats. Identities = 32/86 (37%), Positives = 55/86 (63%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +L Q + RK+ E SY ++L SG+++ A+K GEE VE +AA D+ LT E++D+ Sbjct: 7 RLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEESADV 66 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202 ++H+LV+L +D +V++ L +R Sbjct: 67 LFHMLVMLSSCDVDFKSVLKELERRE 92 >UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQN9_9RICK Length = 103 Score = 85.3 bits (210), Expect = 1e-15, Method: Composition-based stats. Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 + L L + + ERK++ SYT KL + +KV EE E A +++ + Sbjct: 2 FEVLEGLIKTIRERKNSSEHESYTKKLLDN-NSLCREKVMEEIKELVEAL--NEKKNEVH 58 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 EA+D+MYH+LVLL+ + + V+ L+KR Sbjct: 59 EAADVMYHILVLLEANNVKVEDVMNELKKRE 89 >UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae RepID=HIS2_RHOBA Length = 120 Score = 85.3 bits (210), Expect = 1e-15, Method: Composition-based stats. Identities = 35/97 (36%), Positives = 47/97 (48%), Gaps = 3/97 (3%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD--- 165 L L +L L R + PE SYT KL G + I +K+ EE E AA D Sbjct: 2 PESLLPLDRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAG 61 Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 R EA DL+YH +VL+ +G++L V L +R Sbjct: 62 RQHAIYEAGDLIYHAMVLMAWRGIELDEVAAELARRE 98 >UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis RepID=B9RGV5_RICCO Length = 193 Score = 84.5 bits (208), Expect = 2e-15, Method: Composition-based stats. Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 7/95 (7%) Query: 113 LFLYQLEQLLAERKSADPET-----SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167 LY LE +++RK+ S+T +L + K+ EE E ++ Sbjct: 84 TTLYSLESTISQRKAELAAPQEGKPSWTRRLL-DDPNLLCSKIREEADELCRTLEENEHS 142 Query: 168 -ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +E D++YH +VLL + + + V++ LR+R Sbjct: 143 IHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177 >UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WMR5_EGGLE Length = 163 Score = 77.9 bits (191), Expect = 2e-13, Method: Composition-based stats. Identities = 34/134 (25%), Positives = 48/134 (35%), Gaps = 35/134 (26%) Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161 S ++ L +A R+ A E SYT +L + +KV EE ETALAA Sbjct: 9 SGEMPPSSQIGATFEALAATIAARREAG-EESYTYRLLTGSLDGVLKKVMEEAGETALAA 67 Query: 162 TVHDR----------------------------------FELTNEASDLMYHLLVLLQDQ 187 + L EA+D++YHLLV+L+ Sbjct: 68 KDVESWACSSLAASIAASGAVDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERY 127 Query: 188 GLDLTTVIENLRKR 201 G+ L L R Sbjct: 128 GIGLDEFAAELNNR 141 >UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK Length = 90 Score = 77.6 bits (190), Expect = 2e-13, Method: Composition-based stats. Identities = 30/93 (32%), Positives = 44/93 (47%), Gaps = 6/93 (6%) Query: 114 FLYQLEQLLA---ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L LE L+ +RKS+ E SYT KL KV EE E A + Sbjct: 1 MLNTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--I 57 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +EA+D+ YHLL+ L+ + + V++ L R + Sbjct: 58 HEAADVFYHLLMYLEANDVKIEEVMQELENRKK 90 >UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces RepID=HIS2_STRCO Length = 90 Score = 77.2 bits (189), Expect = 3e-13, Method: Composition-based stats. Identities = 26/76 (34%), Positives = 39/76 (51%) Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 + + DP TS TA+L G I +KV EE E +AA + E S L+YH+ V Sbjct: 15 HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74 Query: 183 LLQDQGLDLTTVIENL 198 ++ +G+ L V +L Sbjct: 75 MMVARGISLDDVYAHL 90 >UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales RepID=HIS2_STRGG Length = 90 Score = 76.8 bits (188), Expect = 5e-13, Method: Composition-based stats. Identities = 26/75 (34%), Positives = 38/75 (50%) Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 + DP TS TA+L G I +KV EE E +AA + E S L+YH+ V+ Sbjct: 16 KAAEGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVM 75 Query: 184 LQDQGLDLTTVIENL 198 + +G+ L V +L Sbjct: 76 MVARGISLDDVYAHL 90 >UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria RepID=HIS2_METS4 Length = 107 Score = 72.2 bits (176), Expect = 1e-11, Method: Composition-based stats. Identities = 40/91 (43%), Positives = 59/91 (64%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L L++++ R +A P+ SYTAKL A+G + A+K+GEE VE A+AA DR L Sbjct: 2 TAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGLV 61 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +EA+D++YHLLV+L G+ L V+ L +R Sbjct: 62 SEAADVLYHLLVVLVGSGVALEDVMAELERR 92 >UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria RepID=Q4JVP0_CORJK Length = 332 Score = 71.4 bits (174), Expect = 2e-11, Method: Composition-based stats. Identities = 27/83 (32%), Positives = 37/83 (44%) Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 L L+ R PE S T K +G +K+ EE E LAA EL E S Sbjct: 250 DSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDEELAEEISQ 309 Query: 176 LMYHLLVLLQDQGLDLTTVIENL 198 L+Y L V++ +GL + + L Sbjct: 310 LLYWLQVVMVGRGLTPADIYKYL 332 >UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RQ70_FIBSS Length = 86 Score = 71.0 bits (173), Expect = 2e-11, Method: Composition-based stats. Identities = 25/83 (30%), Positives = 42/83 (50%) Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 ++ L +RK PE T +L+ G I +K+ EE E+ +AA R E S Sbjct: 4 EEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLELSQ 63 Query: 176 LMYHLLVLLQDQGLDLTTVIENL 198 ++Y++ V++ ++GL L V L Sbjct: 64 VLYYVAVMMAEKGLTLEEVYAKL 86 >UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria RepID=HIS2_MYCLB Length = 93 Score = 66.4 bits (161), Expect = 5e-10, Method: Composition-based stats. Identities = 27/83 (32%), Positives = 35/83 (42%) Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 L L+ER P S T G + +K+ EE E LAA + L E S Sbjct: 11 EDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEEISQ 70 Query: 176 LMYHLLVLLQDQGLDLTTVIENL 198 L+Y VL+ +GL L V L Sbjct: 71 LLYWTQVLMISRGLSLDDVYRKL 93 >UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Streptococcus mutans RepID=Q8DTR6_STRMU Length = 61 Score = 62.1 bits (150), Expect = 1e-08, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 25/45 (55%) Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + A D+ E+ +E +DL+YHL V+L + G+ V L+ R Sbjct: 2 VIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46 >UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GPL2_9DELT Length = 978 Score = 59.5 bits (143), Expect = 7e-08, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 36/84 (42%), Gaps = 3/84 (3%) Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 ++ E+ +S + + + QK+ EE E A D+ + E+SD++ Sbjct: 22 SIIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYELFTAIANGDKESVLKESSDVLEI 78 Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203 L +L+ Q ++ L KR + Sbjct: 79 TLTILKQQNYSFDDLLAELEKRRE 102 >UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZIN5_PLALI Length = 98 Score = 58.7 bits (141), Expect = 1e-07, Method: Composition-based stats. Identities = 24/88 (27%), Positives = 43/88 (48%), Gaps = 3/88 (3%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNEA 173 +LE L R P SY +L +G +A + E+ + A D ++ A Sbjct: 7 RLEAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPAAA 66 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +++++H ++LL+ G DL+TV L +R Sbjct: 67 ANVLFHWMLLLKAYGHDLSTVERELMQR 94 >UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium longum DJO10A RepID=UPI00003932E2 Length = 68 Score = 57.5 bits (138), Expect = 2e-07, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 21/45 (46%) Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117 V ++ DCD D LLV + +G CH G SCF + + Sbjct: 19 YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 63 >UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae RepID=HIS2_PYRIL Length = 94 Score = 54.4 bits (130), Expect = 2e-06, Method: Composition-based stats. Identities = 39/93 (41%), Positives = 54/93 (58%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L +LE+++ R SYT +LY+SG +A+KVGEE VE A+AA + + Sbjct: 2 SCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRIV 61 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EA+DL+YHLLVLL GL L V L +R + Sbjct: 62 EEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94 >UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001699CB9 Length = 128 Score = 52.5 bits (125), Expect = 8e-06, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39 + ++ W+ +GL+P I Q +G++LM+ +MN Sbjct: 3 EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36 >UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ Length = 303 Score = 48.7 bits (115), Expect = 1e-04, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 25/56 (44%) Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 ++ KV EE E A A D ++ E DL++ + L + G+D T + Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALR 255 >UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SG07_9BACT Length = 257 Score = 48.3 bits (114), Expect = 1e-04, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 26/61 (42%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVIEN----LRKR 201 EE E A D + E D+ +H++ V+ +++G + V+ L +R Sbjct: 36 FMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVLNEINEKLIRR 95 Query: 202 H 202 H Sbjct: 96 H 96 >UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium retbaense DSM 5692 RepID=C8X332_DESRD Length = 979 Score = 46.4 bits (109), Expect = 6e-04, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 27/56 (48%) Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 QK+ EE E V ++ + E++D++ +L +L+ G +I + R + Sbjct: 47 QKLLEEAYELFTEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102 >UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U6I7_HYDS0 Length = 251 Score = 45.2 bits (106), Expect = 0.001, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 4/60 (6%) Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLRKR 201 +A+ V EE E A D+ + E +DL+ +H + +++ D+ V E L K+ Sbjct: 30 LAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVFELLIKK 89 >UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RLE1_FIBSS Length = 265 Score = 44.0 bits (103), Expect = 0.003, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 25/61 (40%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVIENL----RKR 201 + EE E AA D+ + E D +++H V + + VI+ L +R Sbjct: 36 LVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVIQGLCEKMVRR 95 Query: 202 H 202 H Sbjct: 96 H 96 >UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide pyrophosphohydrolase domain fusion protein n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT Length = 258 Score = 43.3 bits (101), Expect = 0.006, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 29/71 (40%), Gaps = 8/71 (11%) Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195 + + + EE E A D EL +E DL+ +H + +++ + V Sbjct: 27 EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86 Query: 196 ENLR----KRH 202 +N+ +RH Sbjct: 87 QNISEKMIRRH 97 >UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Gluconacetobacter diazotrophicus PAl 5 RepID=A9H4J7_GLUDA Length = 148 Score = 42.9 bits (100), Expect = 0.006, Method: Composition-based stats. Identities = 13/59 (22%), Positives = 24/59 (40%) Query: 145 RIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 RIA+ G + DR L E+++ + L+ + + + V L +R Q Sbjct: 58 RIARAFGLHAEHCVMELIADDRAALIRESAETLTRLMQIWAARNVSADAVWTELDRRTQ 116 >UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria RepID=A8I3U9_AZOC5 Length = 283 Score = 42.5 bits (99), Expect = 0.008, Method: Composition-based stats. Identities = 11/56 (19%), Positives = 25/56 (44%) Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 + + + K+ EE E + A + +E DL++ ++ L + G+D + Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALR 230 >UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D9Q9_9ACTN Length = 336 Score = 42.5 bits (99), Expect = 0.009, Method: Composition-based stats. Identities = 18/65 (27%), Positives = 25/65 (38%), Gaps = 8/65 (12%) Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTV----IEN 197 I + + EE E A D L E D ++ H + L +Q L V E Sbjct: 61 ITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVCHGLAEK 120 Query: 198 LRKRH 202 L +RH Sbjct: 121 LIRRH 125 >UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM Length = 264 Score = 42.1 bits (98), Expect = 0.012, Method: Composition-based stats. Identities = 18/65 (27%), Positives = 27/65 (41%), Gaps = 8/65 (12%) Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVIENLR-- 199 IA+ EE E + +D L E DL+YH+L + + VI+ L Sbjct: 35 IAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDVIQQLAAK 94 Query: 200 --KRH 202 +RH Sbjct: 95 LIRRH 99 >UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase domains n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NET9_KYTSD Length = 144 Score = 41.7 bits (97), Expect = 0.013, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 21/59 (35%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVIENLR----KRH 202 EE E A D L E DL++ H + + + V+ L +RH Sbjct: 44 EEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVVAELEAKLLRRH 102 >UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL Length = 180 Score = 41.7 bits (97), Expect = 0.013, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 21/51 (41%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200 + EE E + A L E +D++Y G+DL V+ + + Sbjct: 85 LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135 >UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HVH1_9BACT Length = 292 Score = 41.0 bits (95), Expect = 0.023, Method: Composition-based stats. Identities = 33/192 (17%), Positives = 60/192 (31%), Gaps = 42/192 (21%) Query: 42 LDKTLESGKVTFFSR-----------TKQRLW----------TKGET----SGNFLNVVS 76 L+++LE G + SR ++ LW G + S + S Sbjct: 71 LEESLEDGDLHNLSREMGDVFIILFMARRILWEQTTVSLGEILDGASLKMVSRHPHVFES 130 Query: 77 IAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER---KSADPE 131 P+ + + H+ S + L+ A R K+ Sbjct: 131 PDPEKSLEAIWETWEEKKRAEAVHQDRRSV---LDGIPRTMPALQA--ASRLGQKAGRVG 185 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191 +T+ L + KV EE E AA LT E D+++ + + G+ Sbjct: 186 FDWTSNL------SVLDKVEEECAE-IRAALSEGSARLTEEIGDMLFAMAQFARLSGIRP 238 Query: 192 TTVIENLRKRHQ 203 + K+ + Sbjct: 239 EEALSEANKKFK 250 >UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LC99_MAGSM Length = 277 Score = 41.0 bits (95), Expect = 0.024, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 25/55 (45%) Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 T I K+ EE E A A +DR E DL++ L+ L + ++ T + Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233 >UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax=Bacillales RepID=A7GLU0_BACCN Length = 108 Score = 41.0 bits (95), Expect = 0.024, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 28/68 (41%), Gaps = 5/68 (7%) Query: 132 TSYTAKLYASG--TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 ++T ++ + + +K EE E A + E +DL+ + L Q +G+ Sbjct: 21 KTFTTRMLDEQEYIEEVCKKTQEELAEYVEA---ESKEHKVEELADLLELVNALAQHEGV 77 Query: 190 DLTTVIEN 197 L V + Sbjct: 78 TLEDVEKV 85 >UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A3P2_NATTJ Length = 384 Score = 41.0 bits (95), Expect = 0.024, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 4/54 (7%) Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIENLR 199 + EE E A + + E DL ++H V + L V+ L+ Sbjct: 143 LIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVLTKLK 196 >UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD Length = 396 Score = 41.0 bits (95), Expect = 0.025, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 24/60 (40%) Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + K+ EE E A +DR + +E D+++ L L + G + +R Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234 >UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces RepID=D1X3V9_9ACTO Length = 335 Score = 41.0 bits (95), Expect = 0.026, Method: Composition-based stats. Identities = 25/107 (23%), Positives = 38/107 (35%), Gaps = 16/107 (14%) Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165 G L L Q++ + P +T++ G + A EE E A D Sbjct: 122 GSYDLPGARLLDLVQVMDRIRRECP---WTSRKTHRGLAKYA---IEEAYELVEAIEDGD 175 Query: 166 RFELTNEASDLM----YHLLVLLQDQGLDL--TTV----IENLRKRH 202 R EL E D++ +H + +D V +E L RH Sbjct: 176 RDELREELGDVLLQVVFHARIAEEDPDEPFAVDDVAGGLVEKLIHRH 222 >UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S3J2_SALRD Length = 281 Score = 41.0 bits (95), Expect = 0.027, Method: Composition-based stats. Identities = 23/110 (20%), Positives = 39/110 (35%), Gaps = 14/110 (12%) Query: 101 TSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160 S F + A + L ++ + + P + + K + EE E A Sbjct: 13 YESQFAEPAERLEAYADLAAIVKQLRRDCP---WDREQTHESVKHLL---IEEAYEVVAA 66 Query: 161 ATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIE----NLRKRH 202 D EL E D+ ++H ++ + L VIE L +RH Sbjct: 67 IDHGDWDELAEELGDVLLHVLFHAVIAEEGGRFTLADVIEAETDKLVRRH 116 >UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9 Length = 302 Score = 41.0 bits (95), Expect = 0.028, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 21/55 (38%) Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 + + KV EE E A E+ E DL++ + L + +D I Sbjct: 201 DARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIR 255 >UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZU0_9BACT Length = 283 Score = 40.6 bits (94), Expect = 0.030, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 26/61 (42%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI----ENLRKR 201 + EE E A +L E +DL ++H + + + D+ V+ + + +R Sbjct: 57 LVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVMKLCLDKMMRR 116 Query: 202 H 202 H Sbjct: 117 H 117 >UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GIZ4_9FIRM Length = 481 Score = 40.6 bits (94), Expect = 0.033, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 24/59 (40%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202 EE E A D +L E DL+ +H + ++Q ++ E L +RH Sbjct: 262 EEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIVAGITEKLVRRH 320 >UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6 Tax=Bacteria RepID=Q3AFK8_CARHZ Length = 479 Score = 40.6 bits (94), Expect = 0.035, Method: Composition-based stats. Identities = 16/59 (27%), Positives = 24/59 (40%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202 EE E A A D +L E DL+ +H + ++ V+ E L +RH Sbjct: 264 EEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVVEGICEKLIRRH 322 >UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF Length = 289 Score = 40.6 bits (94), Expect = 0.036, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202 EE E A A D ++ E D++ +H + + Q DL VI L +RH Sbjct: 59 EEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRH 117 >UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CGC7_KOSOT Length = 256 Score = 40.6 bits (94), Expect = 0.037, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 23/61 (37%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIENLR----KR 201 + EE E A + E E DL ++H + + + V+E L +R Sbjct: 38 LIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVVETLSDKLIRR 97 Query: 202 H 202 H Sbjct: 98 H 98 >UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG family protein n=15 Tax=Bacteria RepID=A4IJD4_GEOTN Length = 486 Score = 40.2 bits (93), Expect = 0.039, Method: Composition-based stats. Identities = 16/56 (28%), Positives = 27/56 (48%) Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 + + I QKV EE E + R EL +E D+M+ L+ L + G+ ++ Sbjct: 387 NDVEPIWQKVEEEMAEFRAETSSGRRAELVSEFGDVMFALINLARYYGIQPEEALQ 442 >UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MG87_RHOM4 Length = 283 Score = 39.8 bits (92), Expect = 0.060, Method: Composition-based stats. Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVI----ENLRKR 201 + EE E A +D EL E DL+ H++ V+ + G L VI E L +R Sbjct: 52 LIEEAYEVVSAIEENDWEELKRELGDLLLHVVFHSVMAEQAGRFTLKDVIETETEKLIRR 111 Query: 202 H 202 H Sbjct: 112 H 112 >UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus kandleri RepID=Q8TY54_METKA Length = 103 Score = 39.8 bits (92), Expect = 0.060, Method: Composition-based stats. Identities = 21/79 (26%), Positives = 31/79 (39%), Gaps = 14/79 (17%) Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 RK E S A+L EE +E A +R L E DL+ + L Sbjct: 30 RKDRAVEVSTGARLV------------EEAIEVRNAVRSGNREALIEELGDLLIEVEAFL 77 Query: 185 QDQGLDLTTVIENLRKRHQ 203 +DL ++E R+R + Sbjct: 78 TAHDIDLEEIVE--RQRTK 94 >UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C338_SPHTD Length = 466 Score = 39.4 bits (91), Expect = 0.072, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 22/59 (37%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLM---Y-HLLVLLQDQGLDLTTVIENLR----KRH 202 EE E A D L E DL+ Y H + + L VI +L +RH Sbjct: 272 EEAYEVLEAIERDDAAALREELGDLLLQVYLHAQIAEEAGEFTLEDVIGDLSAKLVRRH 330 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero... 267 1e-70 UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri... 266 3e-70 UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ... 265 7e-70 UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac... 263 2e-69 UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob... 261 8e-69 UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon... 260 2e-68 UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell... 258 7e-68 UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI... 258 1e-67 UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri... 257 1e-67 UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter... 255 8e-67 UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm... 253 2e-66 UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 251 8e-66 UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 251 9e-66 UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific... 248 8e-65 UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi... 247 1e-64 UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell... 247 2e-64 UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy... 245 5e-64 UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact... 245 5e-64 UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba... 245 5e-64 UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac... 245 8e-64 UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl... 245 8e-64 UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 245 1e-63 UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana... 243 3e-63 UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl... 241 9e-63 UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul... 239 4e-62 UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm... 238 7e-62 UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p... 238 9e-62 UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ... 236 3e-61 UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy... 235 6e-61 UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy... 234 1e-60 UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote... 234 1e-60 UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 233 2e-60 UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman... 233 2e-60 UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy... 232 5e-60 UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor... 232 8e-60 UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI... 231 1e-59 UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos... 230 1e-59 UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 230 2e-59 UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu... 230 2e-59 UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5 230 2e-59 UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His... 230 3e-59 UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI... 228 6e-59 UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep... 228 7e-59 UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His... 228 9e-59 UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte... 228 1e-58 UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu... 226 3e-58 UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos... 225 7e-58 UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 225 8e-58 UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero... 225 9e-58 UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ... 225 1e-57 UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl... 222 9e-57 UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy... 216 3e-55 UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p... 215 8e-55 UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper... 208 1e-52 UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A... 207 1e-52 UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ... 199 5e-50 UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI... 198 1e-49 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 197 2e-49 UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom... 189 4e-47 UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T... 188 8e-47 UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1... 188 1e-46 UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros... 187 1e-46 UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz... 185 6e-46 UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo... 182 6e-45 UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor... 175 6e-43 UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu... 174 2e-42 UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu... 174 2e-42 UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon... 171 1e-41 UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte... 168 9e-41 UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter... 168 1e-40 UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter... 167 2e-40 UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte... 167 2e-40 UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap... 167 2e-40 UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo... 166 3e-40 UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu... 166 4e-40 UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 166 4e-40 UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell... 164 2e-39 UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin... 164 2e-39 UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar... 163 3e-39 UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul... 163 3e-39 UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte... 163 4e-39 UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap... 163 4e-39 UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap... 162 7e-39 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 162 7e-39 UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin... 162 8e-39 UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo... 161 1e-38 UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote... 161 1e-38 UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T... 161 2e-38 UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote... 161 2e-38 UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte... 160 2e-38 UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul... 160 2e-38 UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 160 3e-38 UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul... 160 3e-38 UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote... 160 4e-38 UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch... 159 5e-38 UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein... 159 5e-38 UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm... 159 5e-38 UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy... 159 5e-38 UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein... 159 7e-38 UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax... 158 7e-38 UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte... 158 9e-38 UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote... 157 2e-37 UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu... 156 3e-37 UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin... 156 3e-37 UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob... 156 3e-37 UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact... 156 4e-37 UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob... 156 4e-37 UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob... 156 4e-37 UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte... 155 6e-37 UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon... 155 8e-37 UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero... 155 1e-36 UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan... 154 1e-36 UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu... 154 2e-36 UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte... 153 5e-36 UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax... 153 5e-36 UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter... 152 5e-36 UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote... 152 6e-36 UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p... 152 6e-36 UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ... 152 7e-36 UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=... 150 4e-35 UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob... 150 4e-35 UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap... 150 4e-35 UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo... 149 5e-35 UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu... 149 5e-35 UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro... 149 6e-35 UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin... 148 8e-35 UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo... 148 9e-35 UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr... 148 9e-35 UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing... 147 2e-34 UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero... 147 2e-34 UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom... 146 5e-34 UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing... 145 1e-33 UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl... 144 1e-33 UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo... 141 2e-32 UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax... 139 6e-32 UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha... 135 7e-31 UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico... 134 2e-30 UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros... 131 1e-29 UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing... 130 2e-29 UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr... 129 6e-29 UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos... 127 2e-28 UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo... 124 1e-27 UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1... 123 3e-27 UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos... 119 7e-26 UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid... 117 2e-25 UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T... 116 4e-25 UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu... 116 6e-25 UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact... 115 1e-24 UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=... 113 5e-24 UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact... 111 1e-23 UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost... 111 1e-23 UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm... 111 1e-23 UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C... 111 1e-23 UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph... 110 2e-23 UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh... 110 3e-23 UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo... 109 4e-23 UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap... 109 6e-23 UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta... 108 1e-22 UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto... 108 1e-22 UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph... 108 1e-22 UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi... 108 2e-22 UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell... 108 2e-22 UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk... 108 2e-22 UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri... 107 2e-22 UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins... 106 6e-22 UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto... 106 6e-22 UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul... 106 6e-22 UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote... 106 7e-22 UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot... 105 8e-22 UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot... 105 9e-22 UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha... 105 1e-21 UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra... 105 1e-21 UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl... 104 1e-21 UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 104 2e-21 UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom... 104 2e-21 UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther... 104 2e-21 UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot... 104 3e-21 UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi... 103 4e-21 UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor... 103 5e-21 UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha... 102 8e-21 UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha... 102 8e-21 UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph... 101 1e-20 UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br... 100 5e-20 UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 99 7e-20 UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha... 99 1e-19 UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu... 99 1e-19 UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph... 98 1e-19 UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo... 98 1e-19 UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=... 97 3e-19 UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu... 97 3e-19 UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob... 97 3e-19 UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=... 96 5e-19 UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury... 95 1e-18 UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov... 93 4e-18 UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin... 93 6e-18 UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom... 92 1e-17 UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re... 91 2e-17 UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo... 90 7e-17 UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre... 89 1e-16 UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti... 88 1e-16 UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost... 87 4e-16 UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact... 85 1e-15 UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba... 84 3e-15 UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p... 84 3e-15 UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta... 82 9e-15 UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob... 82 1e-14 UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc... 82 1e-14 UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 82 1e-14 UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo... 81 1e-14 UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha... 81 3e-14 UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus... 80 4e-14 UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac... 79 1e-13 UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=... 78 2e-13 UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo... 77 3e-13 UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth... 76 5e-13 UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax... 71 2e-11 UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph... 64 4e-09 UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase... 59 9e-08 UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas... 59 1e-07 UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax... 59 1e-07 UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID... 54 3e-06 UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp.... 53 4e-06 UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip... 51 2e-05 UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax... 51 2e-05 UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm... 51 2e-05 Sequences not found previously or not previously below threshold: UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog... 48 2e-04 UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma... 48 3e-04 UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact... 47 4e-04 UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil... 47 4e-04 UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm... 46 7e-04 UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1... 46 7e-04 UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip... 46 9e-04 UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ... 46 9e-04 UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID... 46 0.001 UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus... 46 0.001 UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R... 45 0.001 UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ... 45 0.001 UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frank... 45 0.001 UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=A... 45 0.002 UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=... 45 0.002 UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC... 45 0.002 UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640... 45 0.002 UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX Re... 44 0.002 UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB... 44 0.004 UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str... 44 0.004 UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepI... 43 0.005 UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Str... 43 0.006 UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY... 43 0.006 UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC... 43 0.007 UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii K... 43 0.007 >UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C4Y5_SPHTD Length = 228 Score = 267 bits (684), Expect = 1e-70, Method: Composition-based stats. Identities = 86/205 (41%), Positives = 121/205 (59%), Gaps = 10/205 (4%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 + ++ GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGE Sbjct: 14 VDAVRFD-ERGLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGE 72 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQ 117 TSGN VV I PDCD D LLV P GPTCH GT +CF + + Sbjct: 73 TSGNVHEVVEIRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDE 132 Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 + +++AER++ E SYT L +G +I +K+GEE E +AA D L NEA+DL+ Sbjct: 133 VARVVAERRAHPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLI 192 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202 YHLLVLL+ + V LR R Sbjct: 193 YHLLVLLEASDVPTERVWAVLRTRR 217 >UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria RepID=C6PCK8_CLOTS Length = 228 Score = 266 bits (681), Expect = 3e-70, Method: Composition-based stats. Identities = 80/204 (39%), Positives = 118/204 (57%), Gaps = 9/204 (4%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 +L ++ GL+P IVQ + EVLM+ YMN E+L+K+LE+ + FFSR++Q LW KG Sbjct: 8 NIDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKG 66 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD--------TAHQWLFLYQ 117 ETSGN ++ +I DCD DTLLV P GP CH G +SCF + L Sbjct: 67 ETSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSN 126 Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 L + + RK SYT L+ G +I +K+GEE E +A+ + E+ E +D + Sbjct: 127 LYRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYI 186 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 YHL+VL+ ++G++L V + + KR Sbjct: 187 YHLMVLMVEKGINLNDVYKEISKR 210 >UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT Length = 215 Score = 265 bits (677), Expect = 7e-70, Method: Composition-based stats. Identities = 98/196 (50%), Positives = 135/196 (68%), Gaps = 2/196 (1%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++D++K GL+P ++Q + VLMLGYMN EA KT+E+ KVTF+SR++ LWTKGETS Sbjct: 2 QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126 GN+L++VSI DCDNDTLLV +P GPTCH GT +C+G+T + LFL +L+ + R Sbjct: 62 GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 P+ SYT L+ G ++IAQKVGEE VET + A + L EASD++YHL+VLL Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181 Query: 187 QGLDLTTVIENLRKRH 202 +GL + + L +RH Sbjct: 182 KGLHIEDLARELARRH 197 >UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria RepID=HIS2_VIBVY Length = 211 Score = 263 bits (673), Expect = 2e-69, Method: Composition-based stats. Identities = 129/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 ++WEK DGL+P IVQ S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL Sbjct: 7 EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---GDTAHQWLFLYQL 118 WTKGETSGN L +V+++ DCDNDTLLV NPIGPTCH GT++C+ Q ++L+QL Sbjct: 67 WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT D+ EL E++DL+Y Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 HLLVLLQDQGL + VI L++RH+ Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211 >UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria RepID=B5EQF3_ACIF5 Length = 230 Score = 261 bits (668), Expect = 8e-69, Method: Composition-based stats. Identities = 80/209 (38%), Positives = 111/209 (53%), Gaps = 12/209 (5%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + W DGL+P I Q A SG VLML +MN +AL TL G T++SR++Q LW K Sbjct: 10 AILAAVRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRK 68 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ---- 120 GETSG+ ++V + DCD DTLL+ GP CH G +CF Sbjct: 69 GETSGHIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGS 128 Query: 121 -------LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L R++ADP SY A+L G RI +KVGEE E +A H+ + EA Sbjct: 129 ILDSLQVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEA 188 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL++HL+V L+++ L + V+ L +R Sbjct: 189 ADLVFHLMVALEERDLHIDDVLGELARRE 217 >UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae RepID=C4V2J2_9FIRM Length = 235 Score = 260 bits (665), Expect = 2e-68, Method: Composition-based stats. Identities = 79/220 (35%), Positives = 116/220 (52%), Gaps = 22/220 (10%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M + + D GL+P IVQ + +VLML YMN E+L+KT+E+G ++SR++Q+ Sbjct: 2 MNVDMSMIQFD---DRGLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQK 57 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105 LW KGETSGN + I+ DCD DT+L+ G CH GT SCF Sbjct: 58 LWKKGETSGNVQRIKEISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIP 117 Query: 106 ---GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162 + L L Q++ R+ E SYT L+ G +I +K+GEE ET +A+ Sbjct: 118 LIEKEEHPLTEVLASLYQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASK 177 Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + R ++ E DL YH LVLL + ++E L++R+ Sbjct: 178 NNIREDVLYEMGDLWYHCLVLLAYHNMTPEDLLEELKRRN 217 >UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms RepID=HIS2_SYNPX Length = 222 Score = 258 bits (660), Expect = 7e-68, Method: Composition-based stats. Identities = 72/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L+ +L + GL+P I Q + G VLM+ +MN E++ +TL SG+ ++SR++Q L Sbjct: 4 LSPAFIDQLRF-NEAGLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLF------ 114 W KG TSG+ + SI DCD D LL+ G CH G SCF + Q Sbjct: 63 WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122 Query: 115 ------LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 +L +++ R+ E SYT KL G +I +K+GEE E +A + E Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + EA+D+++H+ V L G+ V E L R Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216 >UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria RepID=Q2JWX9_SYNJA Length = 231 Score = 258 bits (659), Expect = 1e-67, Method: Composition-based stats. Identities = 78/198 (39%), Positives = 107/198 (54%), Gaps = 9/198 (4%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P IVQ + G VLM+ +MN E+L KTLE+G+ F+SR++Q LW KGETSG+ Sbjct: 31 NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQW 90 Query: 74 VVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFG--------DTAHQWLFLYQLEQLLAE 124 V I DCD+D L++L +G CH G SCF D L Q+ ++ Sbjct: 91 VKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKA 150 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R++ SYT+ L A G I +K+GEE E +AA D+ L E +DL YH LV L Sbjct: 151 RQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVAL 210 Query: 185 QDQGLDLTTVIENLRKRH 202 +D+ V L+ R Sbjct: 211 AHHQVDIRDVYRQLQARR 228 >UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria RepID=C6J1M1_9BACL Length = 231 Score = 257 bits (658), Expect = 1e-67, Method: Composition-based stats. Identities = 92/213 (43%), Positives = 128/213 (60%), Gaps = 13/213 (6%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 E + + W+ GL+P IVQ A S EVLML YMN E+L K++E+G+ F+SR++ LW Sbjct: 15 IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------AH 110 KG TSGN + ++ DCD DTLLV GP CH G +CF T Sbjct: 74 NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133 Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 ++ L +LEQL+AER + PE +YT L+ G +I +KVGEE E+ +AA D EL Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E SDL+YHLLVLL+++ L L +++ L +RH+ Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226 >UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria RepID=A9B1U1_HERA2 Length = 212 Score = 255 bits (651), Expect = 8e-67, Method: Composition-based stats. Identities = 104/203 (51%), Positives = 130/203 (64%), Gaps = 10/203 (4%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 EL ++ + GL+P +VQHA SGEVLM+GYMN EAL KT SG VTF+SR++Q+LWTKGETS Sbjct: 3 ELTYD-SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL---------FLYQLE 119 GN L ++ DCDND LL+LA P GPTCH G+ SCF T F+ QL Sbjct: 62 GNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLF 121 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 + L ER+ P SYT L G +I +K+GEE E +AA + EL NEASDL+YH Sbjct: 122 EFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYH 181 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 L VLL +QG+ V LR+RH Sbjct: 182 LFVLLLNQGVSPEDVWFTLRERH 204 >UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes RepID=HIS2_OCEIH Length = 215 Score = 253 bits (647), Expect = 2e-66, Method: Composition-based stats. Identities = 84/207 (40%), Positives = 120/207 (57%), Gaps = 6/207 (2%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M L ++ GL+P IVQ SG+VL L YMN +++ KT+E+ + F+SR +Q Sbjct: 1 MTKSISIEHLQFD-EKGLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQE 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----L 115 LW KG TSGN V I+ DCD D +LVL + GP CH G SCF + ++ + Sbjct: 60 LWNKGATSGNKQTVKQISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQII 119 Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 Q+ + ER E +YT+ L+ G +I +K+GEE E +AA D+ ELT+E SD Sbjct: 120 PQVSAKIKERHEHPVEGAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSD 179 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202 L+YH LVL++ QG+ L + + L KRH Sbjct: 180 LLYHSLVLMEQQGVTLEDIKKELYKRH 206 >UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Legionella RepID=C6N0X1_9GAMM Length = 207 Score = 251 bits (642), Expect = 8e-66, Method: Composition-based stats. Identities = 95/198 (47%), Positives = 131/198 (66%), Gaps = 1/198 (0%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 LDW+K +GL+P I+Q+A +G VLMLGYMN EAL T+ +G++T +SR+++RLW KGE Sbjct: 6 ISALDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGE 65 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQLLAER 125 TSGN + V I+ DCD+D+LL++ P GP CH G +SC+ H F+ L +++ ER Sbjct: 66 TSGNTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINER 125 Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185 E SYTA+L ASG R AQKVGEE VET +AA E NE +DL++HLLVLL+ Sbjct: 126 AETQAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLK 185 Query: 186 DQGLDLTTVIENLRKRHQ 203 L V++ L+ R + Sbjct: 186 ASELSFYDVLQCLQDRDR 203 >UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=10 Tax=Bacteria RepID=C0QVS5_BRAHW Length = 220 Score = 251 bits (642), Expect = 9e-66, Method: Composition-based stats. Identities = 77/205 (37%), Positives = 115/205 (56%), Gaps = 6/205 (2%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + + +L ++ GL+P IV + EVL L YMN E+L+ +++ K F+SR++Q L Sbjct: 4 INQNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQEL 62 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL-----Y 116 W KGETSGN+ ++ SI DCDND L++ GP CH G+ SCF + + Sbjct: 63 WRKGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSID 122 Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +L +L+ RK E SYT L+ SG +I +KVGEE E + A E E SDL Sbjct: 123 KLYKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDL 182 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201 +YH LVL+ ++G+ + + L R Sbjct: 183 LYHSLVLMVEKGITINDIKNELASR 207 >UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae RepID=B4U8T9_HYDS0 Length = 207 Score = 248 bits (634), Expect = 8e-65, Method: Composition-based stats. Identities = 80/205 (39%), Positives = 117/205 (57%), Gaps = 9/205 (4%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ ++ GL+PVI Q A SGE+ ML Y N EA+ KT+E+G +FSR++ +W KGE Sbjct: 3 IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG-------DTAHQWLFLYQL 118 TSG V+ I DCDNDTL+ + CH G +CF + + L L Sbjct: 62 TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 E+L+ +R S E+SYT+KL G RI QKVGEE +E+ +A D+ E+ E +DL+Y Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 H+LV ++ + V L +RH+ Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206 >UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3 Tax=Clostridiales RepID=C4Z9Z2_EUBR3 Length = 427 Score = 247 bits (632), Expect = 1e-64, Method: Composition-based stats. Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%) Query: 1 MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56 +L + +L W +DG++PVIVQ + +VLML YMN EA + T+ SG++T++SR Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274 Query: 57 TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108 ++ LWTKG TSG+ V S+ DCD DT+L + +G CH +CF + Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334 Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + L + ++ +R E SYT + G I +K+G E E LAA D + Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 L E SD MYH ++L+ + + + L +R Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427 >UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms RepID=HIS2_THEP3 Length = 216 Score = 247 bits (631), Expect = 2e-64, Method: Composition-based stats. Identities = 79/215 (36%), Positives = 114/215 (53%), Gaps = 22/215 (10%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 E +EL ++ GL+PVI Q + EVLM+ Y+ L K+LE+GKV +FSR++ +LW Sbjct: 2 ENILKELKFDDR-GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-------------- 109 KGETSG+F + SI+ DCD DTLL+ + CH G SCF Sbjct: 61 KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120 Query: 110 -------HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162 L ++ ++ +R E SYT L+ G +I +KVGEE E + A Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180 Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197 D+ E+ E SDL+YHLLVL+ ++G+ L + E Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215 >UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI Length = 244 Score = 245 bits (627), Expect = 5e-64, Method: Composition-based stats. Identities = 85/218 (38%), Positives = 115/218 (52%), Gaps = 27/218 (12%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + W+ GL+P I Q ++S EVLML YMN EAL+ TL++G +FSR+KQR+W KGE SG Sbjct: 6 IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------------- 106 N V I DCD+D++L+ N G CH G SCF Sbjct: 65 NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124 Query: 107 ---DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163 + + + L L L ERK+AD TSYTA L+A GT IA+K+ EE E A Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 D E+ E +D+ YH+LV L + + + + L KR Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222 >UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria RepID=HIS2_XANCP Length = 206 Score = 245 bits (627), Expect = 5e-64, Method: Composition-based stats. Identities = 115/197 (58%), Positives = 135/197 (68%), Gaps = 2/197 (1%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 LDW K DGL+PVIVQ A + VLMLGYMN EAL T G+VTFFSR+KQRLWTKGE Sbjct: 12 LDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGE 71 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 +SGN L VV+I DCD DTLLV A P GPTCH G +SCF FL L+ L+AER+ Sbjct: 72 SSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTA--PSQFLGSLDALIAERE 129 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 P SYT KL+ G +RIAQKVGEEGVETALA V EL E++DL+YHL+VLL+ Sbjct: 130 HERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRA 189 Query: 187 QGLDLTTVIENLRKRHQ 203 +GL L + L RH+ Sbjct: 190 RGLGLGDAVALLESRHK 206 >UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae RepID=C5SM65_9CAUL Length = 215 Score = 245 bits (627), Expect = 5e-64, Method: Composition-based stats. Identities = 110/202 (54%), Positives = 136/202 (67%), Gaps = 1/202 (0%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 LT LD+ K DGL+P IVQ A + +VLMLGYM+ AL +TL +VTFFSR+K Sbjct: 11 LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLEQ 120 W KGETSG+FLN+VS+ DCD D LLVLA P+GPTCH T+SCF DTA F+ L Sbjct: 71 WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130 Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 ++ +R A P SYTA+L G +IAQKVGEEG+ETALA D EL NEA+DL+YHL Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190 Query: 181 LVLLQDQGLDLTTVIENLRKRH 202 VLL + L V++ LR+RH Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212 >UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria RepID=HIS2_BLOFL Length = 213 Score = 245 bits (625), Expect = 8e-64, Method: Composition-based stats. Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT ++ + L+W K GL+P I+QH++SGEVLMLGYMN E++ T ++G VTFFSR+K R Sbjct: 1 MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KGE+SGN L +++ PDCD D+LL+L P G TCHK T+SCF + FL+QLE Sbjct: 61 LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120 Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 +++ +K+ + ++SYT+ LY SG +RIAQKVGEEG+ETALAA + L +EASD Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L+YHLLVLLQ + L+ VI+ LR R + Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208 >UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus acidocaldarius LAA1 RepID=B7DRK3_9BACL Length = 254 Score = 245 bits (625), Expect = 8e-64, Method: Composition-based stats. Identities = 77/250 (30%), Positives = 115/250 (46%), Gaps = 49/250 (19%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 + + + + ++ GL+PV+ Q A +GEVLM+ Y + EAL +TL +G ++SR+++ Sbjct: 4 VKGDVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRRE 63 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108 W KG TSGN VV + DCD D +L P GP CH G +CF Sbjct: 64 YWRKGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAAD 123 Query: 109 --------------------------------AHQWLFLYQLEQLLAERKSADPETSYTA 136 L +L ++ R P+ SYT Sbjct: 124 EGGAKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTT 183 Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDL 191 L+ G +R+ +K+GEE VE ALA +R E+ +E++DL+YHLLVL + G+ Sbjct: 184 YLFTHGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHP 243 Query: 192 TTVIENLRKR 201 V L KR Sbjct: 244 VDVWRTLEKR 253 >UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIV8_9BACT Length = 234 Score = 245 bits (625), Expect = 1e-63, Method: Composition-based stats. Identities = 77/205 (37%), Positives = 113/205 (55%), Gaps = 14/205 (6%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + ++ GL+P +VQ G +LML YMN EALD+TL++G V F+SR++++LW KGETSG Sbjct: 16 IQFD-ERGLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSG 74 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-------------LY 116 ++L + DCD D LLV A P GPTCH +CF Sbjct: 75 HYLLCKRVFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFD 134 Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +L +++ +RK+ E SY + L G RI +KV EE E LA R E+ +E +DL Sbjct: 135 RLYEMVLQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADL 194 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201 ++H +V L + +T + + L KR Sbjct: 195 IFHSIVALGHCEIPMTAIQQELGKR 219 >UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ Length = 211 Score = 243 bits (620), Expect = 3e-63, Method: Composition-based stats. Identities = 87/202 (43%), Positives = 118/202 (58%), Gaps = 14/202 (6%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V Sbjct: 7 QDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIV 66 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ--------------LEQ 120 S+ DCD DTLL L P GP CH G +SCF + + L Q Sbjct: 67 TSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQ 126 Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 L+ +R P+ SY KL G ++ +KVGEE E A D+ E+ +E++DL++H Sbjct: 127 LIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHT 186 Query: 181 LVLLQDQGLDLTTVIENLRKRH 202 L+ L+ +DL+ V++ L RH Sbjct: 187 LLALKYFQVDLSEVLQELHNRH 208 >UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 RepID=C8WUY1_ALIAD Length = 256 Score = 241 bits (616), Expect = 9e-63, Method: Composition-based stats. Identities = 79/255 (30%), Positives = 116/255 (45%), Gaps = 54/255 (21%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M + + + ++ GL+PV+ Q A +G+VLML Y + EAL +TL +G ++SR+++ Sbjct: 1 MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108 W KG TSGN VV + DCD D +L P GP CH G CF Sbjct: 61 YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120 Query: 109 -------------------------------------AHQWLFLYQLEQLLAERKSADPE 131 A L +L ++ R P+ Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180 Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186 SYT L+ G +R+ +K+GEE VE ALA +R E+ +E++DL+YHLLVL + Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240 Query: 187 QGLDLTTVIENLRKR 201 G+ V + L KR Sbjct: 241 VGVQPADVWQVLEKR 255 >UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms RepID=C9RV77_GEOSY Length = 216 Score = 239 bits (611), Expect = 4e-62, Method: Composition-based stats. Identities = 97/204 (47%), Positives = 128/204 (62%), Gaps = 10/204 (4%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 ++ ++ GL+P IVQ A S EVL L YMN E+L+KTLE+G+ F+SR++Q LW KG T Sbjct: 3 ADIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGAT 61 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---------GDTAHQWLFLYQL 118 SGN VV I DCD D LLVL P GP CH G+ SCF A ++ L +L Sbjct: 62 SGNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNEL 121 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 EQ++A+R + PE SYT L+ G +I +KVGEE E +AA + EL EA+DL+Y Sbjct: 122 EQIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLY 181 Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202 HLLVLL++Q L L V+ L +RH Sbjct: 182 HLLVLLREQKLPLDAVLATLAERH 205 >UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga RepID=HIS2_THEMA Length = 197 Score = 238 bits (608), Expect = 7e-62, Method: Composition-based stats. Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L PV+VQ +GEVLML Y N EAL+ T ++G FFSR +Q++W KGETSGN + VV I Sbjct: 4 LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63 Query: 78 APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQWL------FLYQLEQLLAERKSAD 129 DCD+D L + + CH G SCF H++ F +L +L+ +RK Sbjct: 64 RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123 Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189 PE SYT KL+ G +IA+K GEE VE +DR L E +D+MYHL VL+ D G+ Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183 Query: 190 DLTTVIENLRKRHQ 203 + V+ L KR + Sbjct: 184 TVQDVMRELEKRRK 197 >UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1 Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL Length = 207 Score = 238 bits (608), Expect = 9e-62, Method: Composition-based stats. Identities = 99/197 (50%), Positives = 133/197 (67%), Gaps = 1/197 (0%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 +D+EK +GL+PV+VQ A + +VL L YM+ ALD+T++SG+ TFFSR++ W KGET Sbjct: 5 AAIDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGET 64 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLEQLLAERK 126 SG+ L+VV I DCD+D L++ NP+G CH +SCFG + +LEQ +AER Sbjct: 65 SGDRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERA 124 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 +ADP S+TAKL G KRIAQKVGEEGVETALA EL +EA+DL+YHLLVLL Sbjct: 125 AADPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHA 184 Query: 187 QGLDLTTVIENLRKRHQ 203 + + V++ L R + Sbjct: 185 RNMVFQDVLDVLASRAE 201 >UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium thermophilum RepID=Q67KI1_SYMTH Length = 210 Score = 236 bits (603), Expect = 3e-61, Method: Composition-based stats. Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%) Query: 27 VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86 +G+VLM YMN EAL TLE+G ++SR++Q LW KG TSG+ V I DCD D+L Sbjct: 2 RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61 Query: 87 LVLANPIGPTCHKGTSSCFGD-----------------------TAHQWLFLYQLEQLLA 123 L+L G CH+GT SCF L +L +LA Sbjct: 62 LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 ER++ SYT++L+ G +K+GEE E LA DR L E +DL +H LV Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181 Query: 184 LQDQGLDLTTVIENLRKRH 202 L DQGL V + L R Sbjct: 182 LVDQGLSPADVADQLASRR 200 >UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC Length = 251 Score = 235 bits (601), Expect = 6e-61, Method: Composition-based stats. Identities = 80/237 (33%), Positives = 119/237 (50%), Gaps = 40/237 (16%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + + ++DW+K GL+PV++Q +GEVLM+ YMN EAL+ T +G +FSR+K R+W K Sbjct: 3 ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------------- 108 GE+SGN V S DCDNDTLL+ G CH G SCF + Sbjct: 62 GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121 Query: 109 -AHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 ++ L +L + +RK +ADP+ SY AKLY G +K+ EE E A A R Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181 Query: 167 F---------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 ++ E +DL++H++V L G+ ++ L +R+ Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238 >UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae RepID=D0LRT4_HALO1 Length = 241 Score = 234 bits (598), Expect = 1e-60, Method: Composition-based stats. Identities = 83/204 (40%), Positives = 115/204 (56%), Gaps = 16/204 (7%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L Sbjct: 21 NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG---------------DTAHQWLFLYQL 118 V + DCD D ++V+A P GPTCH GT SCF + L +L Sbjct: 81 VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140 Query: 119 EQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 E ++A R+ AD E SYT L G +I K+ EE E A +R E+ +E +DL+ Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 +H++V L + + L V L +R Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224 >UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria RepID=HIS2_HELHP Length = 231 Score = 234 bits (598), Expect = 1e-60, Method: Composition-based stats. Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + R++DWE+ + L+P IVQ S ++LML Y + ++L+ +L++ +FSR+KQR+W Sbjct: 2 QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107 KGE SG+ ++ + DCDND+L+ + +G CH G SCF Sbjct: 61 KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120 Query: 108 ---TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 + L L ++ +R+ + E SYTA L A G I +K+ EE E A Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 D + E +DL YH+LV L + + V++ LR+R Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217 >UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Flavobacteriales RepID=A4CLC1_9FLAO Length = 206 Score = 233 bits (596), Expect = 2e-60, Method: Composition-based stats. Identities = 88/203 (43%), Positives = 124/203 (61%), Gaps = 6/203 (2%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 + +D+EKT GL+P I+Q + + VLMLGYM+ EAL+ T SGKVTF+SR+K+RLWTKGE Sbjct: 1 MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 +SGNFL V + DCD D LL+ A P GP CH G+ +C+ + + + + Sbjct: 61 SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120 Query: 127 SADPET------SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 +T SY A L GT ++AQKVGEE VET + A D NE++DL++H Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 L+LLQ +G + + L +RH+ Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203 >UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B858_THEAS Length = 205 Score = 233 bits (596), Expect = 2e-60, Method: Composition-based stats. Identities = 94/201 (46%), Positives = 119/201 (59%), Gaps = 6/201 (2%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 ++W D L+PV+VQ A SG VLML Y N EALD TL+ G+ FFSR++ RLW KGET Sbjct: 3 DRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGET 61 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQLL 122 SGN + V+ + DCD D++L L GP CH G SCF LFL++L +++ Sbjct: 62 SGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIV 121 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 +R S + SYT L+ G RIAQKVGEEGVE ALA DR EA+DL+YHL V Sbjct: 122 DQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTV 181 Query: 183 LLQDQGLDLTTVIENLRKRHQ 203 L+ L + L RHQ Sbjct: 182 ALRRVDATLLDAEQVLMARHQ 202 >UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN Length = 215 Score = 232 bits (592), Expect = 5e-60, Method: Composition-based stats. Identities = 83/205 (40%), Positives = 112/205 (54%), Gaps = 8/205 (3%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 E+ ++ +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++ LW KG Sbjct: 2 NIEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKG 60 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ-------L 118 SGN V+ + DCD D +L P GP CH G +CF + Sbjct: 61 AISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKV 120 Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178 + L R PE SY K++ +G RI +K+GEE E +AA R EL EASDL++ Sbjct: 121 YRTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLF 180 Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203 HLL L + GL + L +R+Q Sbjct: 181 HLLFTLTELGLSPQDLARVLWERNQ 205 >UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB5_9BACT Length = 188 Score = 232 bits (591), Expect = 8e-60, Method: Composition-based stats. Identities = 87/187 (46%), Positives = 113/187 (60%), Gaps = 5/187 (2%) Query: 22 IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81 +VQ A SGEVLML Y N E++ TLE G++ F+SR+++ +W KG TSGN L + S+ DC Sbjct: 2 VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61 Query: 82 DNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LYQLEQLLAERKSADPETSYTA 136 D D +L +P+GP CH G SCF H L +L L +R PE SYTA Sbjct: 62 DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121 Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 +L A R+AQK+GEEGVETALA DR + EA+DL+YHLLV L L + Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181 Query: 197 NLRKRHQ 203 L+KRH+ Sbjct: 182 ELKKRHK 188 >UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3 Tax=Chloroflexi RepID=B9KXC5_THERP Length = 218 Score = 231 bits (590), Expect = 1e-59, Method: Composition-based stats. Identities = 82/205 (40%), Positives = 117/205 (57%), Gaps = 9/205 (4%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 + + DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KG Sbjct: 9 LLGAIRFG-ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKG 67 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE- 124 ETSG+ L +V + DCD D LL +P GPTCH G SCF + + + Sbjct: 68 ETSGHVLELVELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILDE 127 Query: 125 -------RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 R SYT+ L +G RIA+K+GEE E +AA + + EA+DL+ Sbjct: 128 LASIIAARAVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLL 187 Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202 YHLLVLLQ G+ V L+ R Sbjct: 188 YHLLVLLQASGVPAGEVWRVLQARR 212 >UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=Q058A1_BUCCC Length = 205 Score = 230 bits (588), Expect = 1e-59, Method: Composition-based stats. Identities = 93/204 (45%), Positives = 131/204 (64%), Gaps = 1/204 (0%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 ML +Q + L+W K +GL+P I QH +SGE+LM GYMN +A DK + + T +SR K+R Sbjct: 1 MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLE 119 +W KGETS NFL V +I+ DCD D +LV NP G TCH SCF + FLY+LE Sbjct: 61 IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 + +K +SY + L++SG RIAQK+GEE VE +A ++ + NE SDL++H Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180 Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203 L +LLQ ++L +I+NL+KR + Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204 >UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Picrophilus torridus RepID=Q6KZD6_PICTO Length = 204 Score = 230 bits (588), Expect = 2e-59, Method: Composition-based stats. Identities = 73/199 (36%), Positives = 111/199 (55%), Gaps = 13/199 (6%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DG++PV+VQ +G+VL L YM+ AL+ T+++G ++SR+ +R+ KGE SGN V Sbjct: 9 NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFLYQLEQLLAE 124 + I DC++++LL+ GP CH G +SCF + L +LE L+ + Sbjct: 69 MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128 Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184 R SYT L SG + I +KVGEE +ET LA+ R + E +DL+YHL+V L Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILAS---GRDRIVYETADLLYHLIVFL 185 Query: 185 QDQGLDLTTVIENLRKRHQ 203 + L V+ L +R + Sbjct: 186 AFNNVSLFDVMNELNRRSK 204 >UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms RepID=HIS2_PYRFU Length = 209 Score = 230 bits (587), Expect = 2e-59, Method: Composition-based stats. Identities = 90/213 (42%), Positives = 124/213 (58%), Gaps = 14/213 (6%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M E+ +++WEK +G++PVIVQ GEVL L YMN EAL KTLE+G ++SR+K R Sbjct: 1 MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AH 110 + KGE SGN V I DCDND LL++ +P GP CH G SCF + Sbjct: 60 IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119 Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 L +LE+++ RK E SYT+KL+ G ++I +K GEE +E +A R + Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E +DL+YHLLVLL + L V+ LR+R + Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209 >UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5 Length = 229 Score = 230 bits (587), Expect = 2e-59, Method: Composition-based stats. Identities = 80/199 (40%), Positives = 107/199 (53%), Gaps = 15/199 (7%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P +VQ ++G+V ML YM E+L +TLE+G+ TFFSR++ LW KG TSGN L V S+ Sbjct: 10 LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE---------------QLL 122 DCD D LL+LA P GPTCH G++SCF + L Sbjct: 70 HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 RK++ SYT KL G I K+ EE E A A + +EA+D++YHLLV Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189 Query: 183 LLQDQGLDLTTVIENLRKR 201 L +G+ L V+ L R Sbjct: 190 GLASRGVPLRAVLSALASR 208 >UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2 Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT Length = 233 Score = 230 bits (586), Expect = 3e-59, Method: Composition-based stats. Identities = 91/209 (43%), Positives = 128/209 (61%), Gaps = 8/209 (3%) Query: 2 LTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTK 58 L+E++ + E G L+P +VQH +G+VLMLGYM EA + T +GKVTFFSR++ Sbjct: 7 LSEKEILSVAEENAFGKADLIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSR 66 Query: 59 QRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL 113 +++W KGETSGN L+V+ I DCD DT+LVLA P+GPTCH G+ SCF + Sbjct: 67 KKIWVKGETSGNGLDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFE 126 Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 +L+ + ERK+ DP+ SYTA L S + +K+ EE E +LA V R +E Sbjct: 127 VWSELQSTVRERKTGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEW 186 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL +H+ V L+ G+ V+E LRKR Sbjct: 187 ADLFFHIAVALEKTGVSWGEVMEILRKRQ 215 >UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum sp. NBC37-1 RepID=A6Q6T8_SULNB Length = 222 Score = 228 bits (583), Expect = 6e-59, Method: Composition-based stats. Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 +DW K + L+P I Q A + +VLML YMN EA + TL +G +FSR+KQR+W KGE+SG Sbjct: 3 IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115 + V + DCD DT+++ G CH G SCF DT + + Sbjct: 62 HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121 Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174 L + ERK+A E S+T KL + + K+ EE E +A ++ E++ Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180 Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201 DL+YH LV L + + V + L +R Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207 >UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS Length = 257 Score = 228 bits (583), Expect = 7e-59, Method: Composition-based stats. Identities = 79/244 (32%), Positives = 114/244 (46%), Gaps = 43/244 (17%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M Q E+ + GL+P I QH +G +LM+ +MN E+L T E + +FSR++Q+ Sbjct: 1 MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFL---- 115 LW KGE SG+F V I DCD D +++ G CH G SCF + Sbjct: 60 LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119 Query: 116 ------------------------------YQLEQLLAERKSADPETSYTAKLYASGTKR 145 L QL+ ERK A+ +TSY + LY G + Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179 Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198 I +KVGEEGVET +AA + +L E +DL +H +V+L L+ +I+ L Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239 Query: 199 RKRH 202 +R Sbjct: 240 GRRQ 243 >UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT Length = 230 Score = 228 bits (582), Expect = 9e-59, Method: Composition-based stats. Identities = 85/206 (41%), Positives = 116/206 (56%), Gaps = 8/206 (3%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + + + L PV+ Q G+VLM+GYMN EA +T+E G+VTFFSR+++RLWT Sbjct: 2 DDAILRTLFPDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWT 61 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT--------AHQWLFL 115 KGE+SG+FL +VS+ DCD DTLL L P GPTCH GT SCF + L Sbjct: 62 KGESSGHFLRLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETL 121 Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 L +A R+ DPETSY A+L + + +K+ EE ET A D +E +D Sbjct: 122 GDLAGTIALRRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMAD 181 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201 L++HLLV ++ V+ L KR Sbjct: 182 LLFHLLVAMERTRTPWEEVVGVLEKR 207 >UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria RepID=HIS2_AQUAE Length = 205 Score = 228 bits (581), Expect = 1e-58, Method: Composition-based stats. Identities = 75/204 (36%), Positives = 116/204 (56%), Gaps = 10/204 (4%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +L + +GL+PVI Q +GEV ML Y N EA+ KTLE+G ++SR+++++W KGETS Sbjct: 3 KLKF-NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT--------AHQWLFLYQLE 119 G V+ + DCD D L+ + CH G +CF + L +L+ Sbjct: 62 GELQKVIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQ 121 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 ++ E+ E SYTAKL + G +R+ QK GEE VET +A ++ E+ E++D++Y Sbjct: 122 DVIREKIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYT 181 Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203 LV L G+D+ V+E L +R + Sbjct: 182 FLVSLSVSGIDIKEVMEELIRRFK 205 >UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms RepID=HIS2_THET2 Length = 214 Score = 226 bits (577), Expect = 3e-58, Method: Composition-based stats. Identities = 81/202 (40%), Positives = 118/202 (58%), Gaps = 6/202 (2%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 + ++ GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGE Sbjct: 3 LSAVRFD-EKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGE 61 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQL 121 TSG+ VV + DCD D ++ P GP CH G +CF + Q+ Sbjct: 62 TSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYAT 121 Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 + ER PE SY A+++ +G RI +K+GEE E LAA + EL +EA+DL++HLL Sbjct: 122 IKERLRTLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLL 181 Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203 + L + GL + + L +RH+ Sbjct: 182 LTLAELGLTPEDLAKTLWERHR 203 >UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NG19_KYTSD Length = 244 Score = 225 bits (574), Expect = 7e-58, Method: Composition-based stats. Identities = 95/222 (42%), Positives = 123/222 (55%), Gaps = 31/222 (13%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 + GL+ +VQ A + VLM+G+M+ AL+ T +G+VTF+SR++ W KGETSGN Sbjct: 22 TDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVKGETSGNT 81 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG------------------------- 106 L+VVS+ DCD D +LV+A P GPTCH G +SCF Sbjct: 82 LDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAASGAGGDA 141 Query: 107 ------DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160 T + L + +AER P SYT L+ GT+RIAQKVGEEGVETALA Sbjct: 142 PASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEEGVETALA 201 Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 EL E++DL+YHL+VLL D+GL L V LR R Sbjct: 202 GVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243 >UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4L5_GEMAT Length = 207 Score = 225 bits (573), Expect = 8e-58, Method: Composition-based stats. Identities = 80/204 (39%), Positives = 111/204 (54%), Gaps = 5/204 (2%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M + LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++ Sbjct: 1 MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KG TSG+ V+S+A DCD D +L GP CH GT+SCF DTA + L+ Sbjct: 60 LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119 Query: 121 LLAERKS---ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177 +A R+ D SYT +L +K+GEE VE A A D T E +DL+ Sbjct: 120 TIAARQQSLRDDERPSYTQRLLT-DRNLRLKKLGEEAVELATACVDGDVERATEETADLL 178 Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201 YH LV L+ G L V L +R Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202 >UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes RepID=C6W0Y7_DYAFD Length = 213 Score = 225 bits (573), Expect = 9e-58, Method: Composition-based stats. Identities = 104/211 (49%), Positives = 133/211 (63%), Gaps = 12/211 (5%) Query: 5 QQRRELDWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + +D+ K DGL+P ++Q +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT Sbjct: 3 ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF--------- 114 KGETSGNFL V IA DCD DTLL+ A P GP CH G +CFG+ Q Sbjct: 63 KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122 Query: 115 --LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 Y ++++ ERK + SYT+ L+ G +IAQKVGEE VE + + D NE Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 SDL++HLLVLL+ + +DL VI+ LR RHQ Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213 >UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR Length = 204 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 91/203 (44%), Positives = 125/203 (61%), Gaps = 1/203 (0%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT Q +L+W+K + L+P+IVQ S E+LM GY N ++L TL+ K+TFFSRTK R Sbjct: 1 MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LWTKGETS N+L V+ I PDCD D+LL L IG TCH SCF + + + Sbjct: 61 LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120 Query: 121 LLAE-RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 + + K + TSYT+ LY G +I+QKVGEE VE +AA D+ + E +DL+YH Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 +LVL + +I+ L+KR+ Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203 >UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD Length = 202 Score = 222 bits (565), Expect = 9e-57, Method: Composition-based stats. Identities = 70/198 (35%), Positives = 102/198 (51%), Gaps = 5/198 (2%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+ W KG Sbjct: 4 LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 TSGN VV++ DCD D +L GP CH GT +CFG L Sbjct: 63 TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAP 122 Query: 127 SADPET---SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 + P+ SYT +L +K+GEE E A D EA+D++YH+LV Sbjct: 123 AERPDDAPPSYTRRLLE-DRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVA 181 Query: 184 LQDQGLDLTTVIENLRKR 201 ++ GL L V L +R Sbjct: 182 VRPLGLSLDDVKAVLARR 199 >UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase n=2 Tax=Francisella philomiragia RepID=B0TY40_FRAP2 Length = 207 Score = 216 bits (551), Expect = 3e-55, Method: Composition-based stats. Identities = 102/201 (50%), Positives = 136/201 (67%), Gaps = 3/201 (1%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + + W+K D L+P I+Q A+ VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTK Sbjct: 4 KIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTK 63 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL--YQLEQLL 122 GE SGNFL + IA DCDND++L+ A P GPTCH G+ SCF +LE+L+ Sbjct: 64 GEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLI 123 Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMYHLL 181 AE+K PE SY L+ G RIAQKVGEEGVE +AA D EL +E +DL++HLL Sbjct: 124 AEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLL 183 Query: 182 VLLQDQGLDLTTVIENLRKRH 202 VLL+++G+ L + + L R+ Sbjct: 184 VLLREKGISLEQICQKLVSRN 204 >UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii RepID=A8HTA8_CHLRE Length = 308 Score = 215 bits (548), Expect = 8e-55, Method: Composition-based stats. Identities = 73/226 (32%), Positives = 117/226 (51%), Gaps = 31/226 (13%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 L W+K + L+ VIVQH +GEV+M + + A+ +TL++G TF+SR++ W K Sbjct: 67 SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107 GETSG+F+NV ++ DCD D+++ L++PIGP CH G +C+ Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185 Query: 108 -----TAHQWLFLYQLEQLLAERKSA------DPETSYTAKLYASGTKRIAQKVGEEGVE 156 L LE+ +A+R+ A + S+TA+L + + + +K+ EE E Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGE 244 Query: 157 TALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 R +E +DL+YH +VL QG+ + V+ LRKR Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290 >UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta RepID=HIS2_ARATH Length = 281 Score = 208 bits (530), Expect = 1e-52, Method: Composition-based stats. Identities = 74/219 (33%), Positives = 112/219 (51%), Gaps = 21/219 (9%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + W+ GL I Q+ +G VLM G++N EAL T+ S K TFFSR++ L Sbjct: 51 KVDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTL 109 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL------ 115 WTKGETS NF+N++ + DCD D+++ L P GPTCH G +C+ + L Sbjct: 110 WTKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGN 169 Query: 116 -------YQLEQLLAERKSA---DPET--SYTAKLYASGTKRIAQKVGEEGVETALAAT- 162 Y LE ++++RK E S+T +L + K+ EE E Sbjct: 170 KLALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADELCRTLED 228 Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + +E +D++YH +VLL +G+ + V+E LRKR Sbjct: 229 NEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267 >UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU Length = 284 Score = 207 bits (528), Expect = 1e-52, Method: Composition-based stats. Identities = 70/220 (31%), Positives = 112/220 (50%), Gaps = 25/220 (11%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 L ++ GL+ I Q +G +LM G+ + +A+ TL + K TF+SR++ LW K Sbjct: 45 AFLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCK 103 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL----------- 113 GETSGNF+ V S+ DCD D+L+ L P GPTCH G +C+ Sbjct: 104 GETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRH 163 Query: 114 -------FLYQLEQLLAERK----SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-A 161 LY+LE + R+ + D + S+T +L + + + +K+ EE E Sbjct: 164 AAEEALTTLYELEATIEARRVEAVADDVKPSWTRRLLDN-PELLCKKIREEAGELCQTWE 222 Query: 162 TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + TNE +D++YH +V+L QG+ ++ V+ LR+R Sbjct: 223 ENEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262 >UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms RepID=HIS2_YEAST Length = 799 Score = 199 bits (506), Expect = 5e-50, Method: Composition-based stats. Identities = 68/203 (33%), Positives = 104/203 (51%), Gaps = 9/203 (4%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLT++ E+ ++ DGL +V L L Y + +++ K ++ G+ ++SR++ Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLE 119 +W KGETSGN ++ I+ DCD+D L + CH T SCFG+ H L LE Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHG---LVGLE 249 Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 LL +R PE SYT +L+ + + + K+ EE E A + EL+ EA+DL Y Sbjct: 250 SLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305 Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202 L L + L V NL +H Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328 >UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2 Tax=Campylobacter RepID=B9D5P8_WOLRE Length = 329 Score = 198 bits (504), Expect = 1e-49, Method: Composition-based stats. Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++DW+K GL+P +VQ + SGEVLML YMN EAL+ +L++G +FSRTK R+W KGE S Sbjct: 2 KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107 GN + I DCDNDT+L+ G CH G SCF Sbjct: 62 GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121 Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159 + + ++ + +RK +ADP+TSY A L+ G I +KVGEE E + Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181 Query: 160 AATVHD 165 A Sbjct: 182 ACKDAS 187 Score = 54.5 bits (130), Expect = 2e-06, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 18/35 (51%) Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E+ EA+DL +H LV L G+ V L +R Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 197 bits (500), Expect = 2e-49, Method: Composition-based stats. Identities = 69/201 (34%), Positives = 104/201 (51%), Gaps = 6/201 (2%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L E LD++K L+P IVQ +G VLML Y PE+L + K +FSR++ L Sbjct: 216 LDEAVMACLDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNEL 274 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 W KG TSGN +++I DCD DTL+ G CH SCF + + L L+++ Sbjct: 275 WEKGLTSGNQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANF-DLDVLDRV 333 Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181 +R + TS++ KL AS +K+ EE E A D+ E+ EA+DL++ L Sbjct: 334 FEQRMQSQEVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFAL 389 Query: 182 VLLQDQGLDLTTVIENLRKRH 202 + +G+ + +I L R+ Sbjct: 390 ARAKSKGVAASDIINELGARN 410 >UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2HFX2_CHAGB Length = 817 Score = 189 bits (481), Expect = 4e-47, Method: Composition-based stats. Identities = 62/191 (32%), Positives = 94/191 (49%), Gaps = 10/191 (5%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ DGL+P +V L L Y + E++ + L++ + SR + LW KG TSG+ Sbjct: 202 KSDRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGD 259 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130 +V I+ DCDND L + G CH S CFGD L +LE L RK + P Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDL----KGLAKLESTLLSRKQSAP 315 Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190 SYTA+L++ K + K+ EE E A + + EA+DL+Y L G+ Sbjct: 316 AGSYTARLFS-DEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVT 371 Query: 191 LTTVIENLRKR 201 L + ++L + Sbjct: 372 LADIEKSLDAK 382 >UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira pseudonana RepID=B8BUA9_THAPS Length = 272 Score = 188 bits (479), Expect = 8e-47, Method: Composition-based stats. Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 13/198 (6%) Query: 10 LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 + ++ DGL +V SGE L L Y + E++ L+SG+ ++SR++ LW KG+TSG Sbjct: 59 VKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSG 117 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125 +F + + DCD D L G CH T +C+G+ L LE L +R Sbjct: 118 HFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEP----RGLRHLEGTLQQR 173 Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185 P SYT +L+ + K+ EE E + A + + E +D++Y +V Sbjct: 174 LKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRAA 229 Query: 186 DQGLDLTTVIENLRKRHQ 203 G+ + +E L +R + Sbjct: 230 KAGVSIDDAVEELDRRTR 247 >UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria RepID=Q2PPB3_PHANO Length = 881 Score = 188 bits (477), Expect = 1e-46, Method: Composition-based stats. Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 17/209 (8%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + ++ DGL +V G L L Y + E++ ++L +G+ + SR + L Sbjct: 191 VAKLVMANATSDRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-L 248 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120 W KGE+SG+ +VS++ DCD+D L + G CH T +CFGD + L +L++ Sbjct: 249 WYKGESSGDIQELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQK 304 Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 L RK + P+ SYTA+L+ + + + K+ EE E A T + + EA+DL Y Sbjct: 305 TLQSRKESAPQGSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFA 360 Query: 181 LVLLQDQGLDLTTVIENLR------KRHQ 203 L G+ L V NL KR Q Sbjct: 361 LTKCVAAGVSLEDVERNLDAKSIKVKRRQ 389 >UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira RepID=B5VZW9_SPIMA Length = 200 Score = 187 bits (476), Expect = 1e-46, Method: Composition-based stats. Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 17/197 (8%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ ++ GL+ + +Q ++G VL LG MN EAL KTL + ++ + +++ LW Sbjct: 21 IDKIRYD-DQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHP-- 77 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 + + SI+ D + L+ C + G L L +++ +R+ Sbjct: 78 ----DIILESISYDYRGNFLVAGV----AYCPSELNGSGGH------TLAGLFRVICDRR 123 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 SYT +L+A G +I +K+GEE E +A + + +E +DL YH LV L Sbjct: 124 DHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAY 183 Query: 187 QGLDLTTVIENLRKRHQ 203 +DL V E L R Q Sbjct: 184 HQVDLRKVYEQLEARRQ 200 >UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces RepID=HIS2_SCHPO Length = 417 Score = 185 bits (471), Expect = 6e-46, Method: Composition-based stats. Identities = 63/203 (31%), Positives = 101/203 (49%), Gaps = 11/203 (5%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L + + ++ DGL +V + + G L L Y + E++ ++L++G + SR + L Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120 W KG +SG +++ I DCD D L + G CH T CFG L QLE+ Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQA----SGLCQLEK 308 Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 L +RK+ PE SYTA+L++ K + K+ EE E A T + + E +DLMY Sbjct: 309 TLIDRKNNAPEGSYTARLFS-DPKLLRAKIMEEAEELCDATT---KENVIWEMADLMYFA 364 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 + G+ L + +L +H+ Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387 >UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota RepID=Q4P7D9_USTMA Length = 896 Score = 182 bits (462), Expect = 6e-45, Method: Composition-based stats. Identities = 61/208 (29%), Positives = 93/208 (44%), Gaps = 13/208 (6%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + L ++TDGL V + L L Y +P ++ K++ +G + SR + L Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CHKGTS-SCFGDTAHQWLFL 115 W KGE+SG VVSI DCD+D + T CH CF L Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSA----TGL 307 Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175 +LE L R P SYTA+L+ + + K+ EE E A A +D+ + EA+D Sbjct: 308 AKLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAAD 365 Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L+Y L G+ L + +L + + Sbjct: 366 LIYFALTKCVSAGIGLEEIEASLDAKAK 393 >UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN Length = 198 Score = 175 bits (445), Expect = 6e-43, Method: Composition-based stats. Identities = 52/197 (26%), Positives = 88/197 (44%), Gaps = 13/197 (6%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ + GL+P I+Q + G VL L +M+ ++L KT E +V + L + Sbjct: 15 IDKIRY-NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLL 73 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 +G + P C + +LV I ++ L ++ +++ +R+ Sbjct: 74 ITGWRYD-----PACQSLLILVECGSIAEPQNE-------FAQVSSNLLSEVFEVICDRR 121 Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186 E SYT KL A G +I +K+GEE E +A D + +E +DL YH LV + Sbjct: 122 DHPQEDSYTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAY 181 Query: 187 QGLDLTTVIENLRKRHQ 203 DL V L +R + Sbjct: 182 HRADLRQVYRKLAERRR 198 >UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1 Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN Length = 477 Score = 174 bits (441), Expect = 2e-42, Method: Composition-based stats. Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 10/198 (5%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + L ++ D L +V +G L L Y + E++ + SG+ ++SR++ LW K Sbjct: 244 AFVKCLRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKK 302 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 GE+SGN ++ I DCD+D L N G CH T +C+G L LE +L Sbjct: 303 GESSGNAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHD----GGLRALESMLF 358 Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 R P SYT +L+ + + K+ E A ++ EA+D+MY +V Sbjct: 359 SRHENAPAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVR 414 Query: 184 LQDQGLDLTTVIENLRKR 201 G L+ V L KR Sbjct: 415 CVAAGCKLSDVERMLDKR 432 >UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms RepID=HIS3_PELLD Length = 137 Score = 174 bits (441), Expect = 2e-42, Method: Composition-based stats. Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 6/133 (4%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + ++ GL+P IVQ +G+VLM+ +MN E+L+ TLE K ++SR++ +LW K Sbjct: 10 SFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLK 68 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 GE+SGN +V I DCD DTL++ + IG CH G SCF + + + + Sbjct: 69 GESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYRRVLENGNM-----EICD 123 Query: 125 RKSADPETSYTAK 137 DPE Y K Sbjct: 124 TLMFDPEEVYGKK 136 >UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4CVB3_9BACT Length = 128 Score = 171 bits (434), Expect = 1e-41, Method: Composition-based stats. Identities = 52/131 (39%), Positives = 71/131 (54%), Gaps = 5/131 (3%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 L + DGL+P IVQ + VLM+ +MN +L+ TL++G + ++SR++Q+ W KGE Sbjct: 3 LPNLKY-TADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGE 61 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 TSG+ VV A DCD DTLL IG CH G SCF + E K Sbjct: 62 TSGHTQKVVRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSPEGTPL----EITEEK 117 Query: 127 SADPETSYTAK 137 DPE +Y +K Sbjct: 118 LFDPEKTYASK 128 >UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria RepID=HIS3_CHLP8 Length = 137 Score = 168 bits (427), Expect = 9e-41, Method: Composition-based stats. Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + + ++ GL+P IVQ +G+VLM+ +MN E+L TLE K ++SR++ +LW Sbjct: 9 KSFLETVKFDDR-GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 KGE+SGN +V I DCD DTLL+ + G CH G SCF + + Sbjct: 68 KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQM-----EIC 122 Query: 124 ERKSADPETSYTAK 137 + DPE Y K Sbjct: 123 DTLMFDPEEVYGKK 136 >UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria RepID=C4XTP1_DESMR Length = 124 Score = 168 bits (425), Expect = 1e-40, Method: Composition-based stats. Identities = 58/125 (46%), Positives = 73/125 (58%), Gaps = 7/125 (5%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 D+ K GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+ Sbjct: 5 DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64 Query: 71 FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 V S+ DCD DT+LVL I G CH+G SCF + K D Sbjct: 65 VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFFTEITSDG------ERTCSPKVFD 118 Query: 130 PETSY 134 P+ Y Sbjct: 119 PKEVY 123 >UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT Length = 116 Score = 167 bits (424), Expect = 2e-40, Method: Composition-based stats. Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 2/108 (1%) Query: 6 QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 +L + D L+P I Q G VLM+ +MN E++ KTL +G+ ++SR++ +LW KG Sbjct: 7 WFEKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKG 65 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112 TSG+ V + DCD DT+L+ IG CH G SCF + + Sbjct: 66 ATSGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113 >UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria RepID=HIS3_RHOPT Length = 151 Score = 167 bits (423), Expect = 2e-40, Method: Composition-based stats. Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 2/127 (1%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ GL+ V+ A +G+VLM+ +MN EALD+T+++G+ ++SR+++RLW KGETSG+ Sbjct: 26 KFD-AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGH 84 Query: 71 FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 V+ + DCD D + + + G CH G SCF + + + D Sbjct: 85 IQKVLEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLIETDAERKFD 144 Query: 130 PETSYTA 136 P+ Y Sbjct: 145 PDKVYGK 151 >UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria RepID=HIS3_RHOPS Length = 147 Score = 167 bits (423), Expect = 2e-40, Method: Composition-based stats. Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 1/124 (0%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ GL+ + A SGEVLM+ +MN EAL+KT++SG+ ++SR+++RLW KGE+SG+ Sbjct: 23 KFDAA-GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGH 81 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130 V+ I DCD D + + G CH G SCF + L ++ + DP Sbjct: 82 VQRVLEIRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTMVDADRLFDP 141 Query: 131 ETSY 134 Y Sbjct: 142 AKIY 145 >UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria RepID=B8J3P0_DESDA Length = 137 Score = 166 bits (422), Expect = 3e-40, Method: Composition-based stats. Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 7/129 (5%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 + + GL+P I Q SGEVLML YMN EA KTLE+G+ ++SR+++++W KG T Sbjct: 14 EAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGT 73 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126 SG+ V+++ DCD+DT+L+ + + G CH G +CF Sbjct: 74 SGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE------WKDGAVSECAPM 127 Query: 127 SADPETSYT 135 DP+ Y Sbjct: 128 VFDPQKVYG 136 >UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms RepID=HIS3_STRTD Length = 112 Score = 166 bits (421), Expect = 4e-40, Method: Composition-based stats. Identities = 47/106 (44%), Positives = 65/106 (61%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +LD++K GL+PVIV +G+VLML YMN + TLE+ ++ ++SR++ LW KG TS Sbjct: 5 KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114 G+F +V SI DCD DTLL+ G CH G SCF + Sbjct: 65 GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYDDNQ 110 >UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3 Length = 140 Score = 166 bits (421), Expect = 4e-40, Method: Composition-based stats. Identities = 48/133 (36%), Positives = 70/133 (52%), Gaps = 5/133 (3%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + + ++K +GL+P I Q +G+VLML YMN E+L+ TL+ K ++SR++Q LW K Sbjct: 10 KLMDIVRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLK 68 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 G TSGNF V+ I+ DCD D +L+ G CH G SCF + + Sbjct: 69 GATSGNFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVENDNSSLS----ICD 124 Query: 125 RKSADPETSYTAK 137 + D E Y Sbjct: 125 KLVFDAEEVYGKS 137 >UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R0U5_9PLAN Length = 310 Score = 164 bits (415), Expect = 2e-39, Method: Composition-based stats. Identities = 41/128 (32%), Positives = 67/128 (52%), Gaps = 1/128 (0%) Query: 11 DWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69 D+ + L+P I Q +GEVLM+ +MN E+ +T+ +G+ ++SR++ +LW KGE SG Sbjct: 173 DFSRGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESG 232 Query: 70 NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129 + V + DCD DT+L+ + +G CH+G SCF E+L+ Sbjct: 233 HMQTVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYK 292 Query: 130 PETSYTAK 137 S+ Sbjct: 293 NPKSHAKS 300 >UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae RepID=HIS3_FRAAA Length = 132 Score = 164 bits (415), Expect = 2e-39, Method: Composition-based stats. Identities = 46/108 (42%), Positives = 62/108 (57%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 GL P I Q +GEVLMLG+M+ EAL +TL +G+ T++SR++ W KG+TSG+ Sbjct: 18 RNDAGLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQ 77 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 V S+A DCD D +LV + IGP CH GT +CF Sbjct: 78 WVRSVALDCDGDAVLVRVDQIGPACHTGTRNCFVADPLPTRVGDPGVT 125 >UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota RepID=HIS3_HALWD Length = 132 Score = 163 bits (414), Expect = 3e-39, Method: Composition-based stats. Identities = 53/131 (40%), Positives = 73/131 (55%), Gaps = 10/131 (7%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + E+ + +DGL+P I Q A SGEVLML Y++P AL +T E+G+ ++SR+++ LW Sbjct: 11 DDAEIEIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWK 69 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 KGETSG+ ++ I DCD DT+L L G CH G SCF T Sbjct: 70 KGETSGHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRTLDGTEVT-------- 121 Query: 124 ERKSADPETSY 134 + DPET Y Sbjct: 122 -ERVFDPETVY 131 >UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms RepID=HIS3_METTH Length = 138 Score = 163 bits (413), Expect = 3e-39, Method: Composition-based stats. Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 4/122 (3%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 + L+ + Q +GEVLM+ YMN EAL +TLE+G ++S ++ +LW KGE+SG+ Sbjct: 19 NGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQR 78 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133 V + DCD D +++ G CH G SCF + + + + K DPE Sbjct: 79 VKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----KVFDPEEI 134 Query: 134 YT 135 Y Sbjct: 135 YG 136 >UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria RepID=HIS3_SALRD Length = 127 Score = 163 bits (412), Expect = 4e-39, Method: Composition-based stats. Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 7/133 (5%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 +++ D+ DGL+P IVQ A + +VLM+ YM E L +TL++G++ ++SR++Q Sbjct: 1 MSDPLLDAADF-TDDGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQER 59 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 W KG+TSG+ V DCD DTLL + G CH G SCF A Sbjct: 60 WVKGQTSGHTQTVEEARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAADDG------WT 113 Query: 122 LAERKSADPETSY 134 K DP+ Y Sbjct: 114 TDGEKVFDPDAVY 126 >UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria RepID=Q2SLC2_HAHCH Length = 139 Score = 163 bits (412), Expect = 4e-39, Method: Composition-based stats. Identities = 45/111 (40%), Positives = 66/111 (59%), Gaps = 1/111 (0%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 EL + GL+PVI Q A + +LM +MN EAL+KT+ + ++T++SR++QRLW Sbjct: 21 PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114 KGETSG+ +VS++ DCD D +L L + G CH G +CF Sbjct: 80 KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFYLQVEPDKQ 130 >UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria RepID=HIS3_DINSH Length = 119 Score = 162 bits (410), Expect = 7e-39, Method: Composition-based stats. Identities = 45/115 (39%), Positives = 68/115 (59%), Gaps = 1/115 (0%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 L ++ GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q W KGE+ Sbjct: 6 ASLRYD-DQGLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGES 64 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122 SG+ +V + DCD D LL+ GP CH +CF + + ++ Sbjct: 65 SGHVQTLVEMRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 162 bits (410), Expect = 7e-39, Method: Composition-based stats. Identities = 51/112 (45%), Positives = 71/112 (63%), Gaps = 1/112 (0%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + ++L + +GL+PV+VQ V+ EVLML YMN EA +KTLE+G +T++SR++Q L Sbjct: 251 KADISFKDLKLD-ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQEL 309 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113 W KG TSG+F V S+ DCDNDT+L +G CH G +CF W Sbjct: 310 WVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWN 361 >UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae RepID=HIS3_ACIC1 Length = 142 Score = 162 bits (410), Expect = 8e-39, Method: Composition-based stats. Identities = 45/99 (45%), Positives = 62/99 (62%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 GL P + Q +GEVLM+G+M+ EAL +TL +G+ T++SR++Q W KGETSG+ Sbjct: 18 RDEHGLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQ 77 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111 V S+A DCD DT+LV + IG CH G +CF Sbjct: 78 WVKSVALDCDGDTVLVKVDQIGAACHTGDRTCFDAGQLP 116 >UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R0N1_9RHOB Length = 156 Score = 161 bits (408), Expect = 1e-38, Method: Composition-based stats. Identities = 47/138 (34%), Positives = 69/138 (50%), Gaps = 5/138 (3%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L ++ + D +GL+ V SGE+LM+GYMN E+L +T+E+G+ ++SR++Q Sbjct: 21 LGDELCPKFD---ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEY 77 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119 W KG TSG V+ I DCD D + V + G TCH G SCF + Sbjct: 78 WKKGGTSGQVQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWL 137 Query: 120 QLLAERKSADPETSYTAK 137 + DP+ Y K Sbjct: 138 EKTEVAPVYDPQEVYGKK 155 >UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria RepID=HIS3_BURS3 Length = 138 Score = 161 bits (408), Expect = 1e-38, Method: Composition-based stats. Identities = 47/132 (35%), Positives = 71/132 (53%), Gaps = 4/132 (3%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 ++ W+ +GL+PVI Q A + +VLM +MN EAL KT+E+ + ++SR+++RLW Sbjct: 9 PAWLDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWF 67 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122 KGE SG+ +V + DCD D +L+ + G CH G SCF + + Sbjct: 68 KGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVE 127 Query: 123 AERKSADPETSY 134 K DPE Y Sbjct: 128 PVLK--DPEHIY 137 >UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured crenarchaeote RepID=Q702A1_9CREN Length = 115 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 42/109 (38%), Positives = 66/109 (60%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 ++ +LD+ K DGL+PV+VQ + ++LML Y N A++ T+++G F+S ++ +LW Sbjct: 7 DEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWM 66 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112 KGE SGN V I DCD D++L L + P CH G +CF + + Sbjct: 67 KGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHNRLYPN 115 >UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria RepID=HIS3_THICR Length = 147 Score = 161 bits (407), Expect = 2e-38, Method: Composition-based stats. Identities = 48/131 (36%), Positives = 72/131 (54%), Gaps = 7/131 (5%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 E ++++ ++ +GL+P I Q S EVLM+ +MN AL +TLE+G+V ++SR++Q W Sbjct: 22 EAVKKQVKYD-DNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR 80 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 KGE SG + + DCD D +L+L + GP CH G SCF H ++ Sbjct: 81 KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPII- 139 Query: 124 ERKSADPETSY 134 DPE Y Sbjct: 140 -----DPEALY 145 >UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria RepID=HIS3_CORJK Length = 127 Score = 160 bits (406), Expect = 2e-38, Method: Composition-based stats. Identities = 43/108 (39%), Positives = 60/108 (55%), Gaps = 1/108 (0%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 L + + DGL+P IVQ +G+VLM+ +MN AL TL + K T++SR++Q Sbjct: 19 LDPAIAERVRF-NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSY 77 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109 W KGETSG+ V + DCD DT+L+ G CH G +CF Sbjct: 78 WIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADR 125 >UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms RepID=HIS3_SOLUE Length = 126 Score = 160 bits (405), Expect = 2e-38, Method: Composition-based stats. Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 7/130 (5%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 LD+ K+DGL+ ++Q SG VLM+GYMN EA +KT+E+G TF+SR++++LW KGE+S Sbjct: 2 NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127 G+ L V I+ DCD D +LV GP CH+G SCF L E +A+ + Sbjct: 62 GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRR------LDAGEWKVADNPT 115 Query: 128 ADPETSYTAK 137 DP Y K Sbjct: 116 YDPGAVYGGK 125 >UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=A4GIE4_9BACT Length = 132 Score = 160 bits (405), Expect = 3e-38, Method: Composition-based stats. Identities = 41/94 (43%), Positives = 64/94 (68%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+P I Q +GEVLM+ +MN +L +TL +G++ ++SR+++ LW KG+TSG+ + Sbjct: 15 ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 + + DCD D++LVL + G CH+GT SCF Sbjct: 75 IELRYDCDADSILVLVDQSGAACHEGTRSCFTRR 108 >UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms RepID=HIS3_GEOSF Length = 126 Score = 160 bits (405), Expect = 3e-38, Method: Composition-based stats. Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++D++K GL+P ++Q SGEVLM+ +M+ + LD TL+ GK FFSRT+ + W KGE Sbjct: 1 MIKIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGE 60 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125 SGN V+ + DCD DT+++ GP CH G SCF + + + Sbjct: 61 ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFY------VKWEDGQWVEHSN 114 Query: 126 KSADPETSY 134 DP Y Sbjct: 115 PLFDPNEVY 123 >UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria RepID=HIS3_SILST Length = 129 Score = 160 bits (404), Expect = 4e-38, Method: Composition-based stats. Identities = 43/108 (39%), Positives = 62/108 (57%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 GL+P I Q SGE+LM+ +MN E++ KTLE+G+VT++SR++Q W KGE+SG+ Sbjct: 21 NEAGLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQE 80 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 +V + DCD D LL + GP CH SCF + + Sbjct: 81 LVELRVDCDRDALLAMVRQTGPACHTNRRSCFYTAIRDGEEHEIMTPI 128 >UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XNB8_HIRBI Length = 139 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 43/108 (39%), Positives = 59/108 (54%) Query: 14 KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73 +DGL+ I Q S EVLML +MN +AL T+E+G+ ++SR++ +LW KG+TSG + Sbjct: 30 NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89 Query: 74 VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 V SI DCD D +L+ CH G SCF L E Sbjct: 90 VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYRQITDLSTLNPTEDK 137 >UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM Length = 151 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 46/114 (40%), Positives = 63/114 (55%), Gaps = 1/114 (0%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 +L + GL+P + Q A +G+VLML +MN A++KTLE+G++T+FSR++ LW K Sbjct: 33 DVIEQLAY-NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVK 91 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118 G SGN +V DCD D LL G CH G SCF A+ L Sbjct: 92 GLASGNHQQLVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145 >UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SGQ9_9ACTO Length = 444 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 43/96 (44%), Positives = 59/96 (61%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 DGL+ +V+ SGEVLM+ +M+ EAL +TL +G+ T++SR++ W KG TSGN Sbjct: 339 RTPDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQ 398 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 V S+A DCD D LLV +G CH G +CF Sbjct: 399 YVRSVALDCDGDALLVSVEQVGAACHTGQRTCFFTE 434 >UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268 RepID=C8PI34_9PROT Length = 336 Score = 159 bits (403), Expect = 5e-38, Method: Composition-based stats. Identities = 54/135 (40%), Positives = 65/135 (48%), Gaps = 3/135 (2%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 ++DW+K GL+P IVQ A G VLML YMN EAL TL +G +FSR+K R+W KGE S Sbjct: 2 KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWL-FLYQLEQLLAERK 126 G+ V S DCDND LL+ G CH G SCF Sbjct: 62 GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKEISLQKCGENVGSSSTCGAI 121 Query: 127 SADPETSYTAKLYAS 141 + S T L Sbjct: 122 NFAEHGS-TTSLAQK 135 Score = 66.0 bits (160), Expect = 8e-10, Method: Composition-based stats. Identities = 28/132 (21%), Positives = 46/132 (34%), Gaps = 24/132 (18%) Query: 93 IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVG 151 + + L ++ + +RK P SY A LYA G +K+ Sbjct: 194 DAAAQNSTL--ENSAEKGPYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251 Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190 EE E ALA R EL + + D++Y LL+ L + Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311 Query: 191 LTTVIENLRKRH 202 +++ L +R Sbjct: 312 PDALLDELARRQ 323 >UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria RepID=B9QYY7_9RHOB Length = 159 Score = 159 bits (402), Expect = 7e-38, Method: Composition-based stats. Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 +++ DGL+ +V + EVLM+GYMN EAL +T+E+G+ ++SR+++ W KGETSG Sbjct: 32 KFDQ-DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQ 90 Query: 71 FLNVVSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 V I DCD D L+V G TCH G SCF + + K Sbjct: 91 IQKVQEILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANVEKEKVY 150 Query: 129 DPETSYTA 136 DP+ Y Sbjct: 151 DPKKVYGK 158 >UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2 RepID=UPI000050F746 Length = 123 Score = 158 bits (401), Expect = 7e-38, Method: Composition-based stats. Identities = 48/111 (43%), Positives = 67/111 (60%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 T + REL +DGL+PVIVQ + EVLM+ +M+ EA+++TL +G ++SR++Q W Sbjct: 13 TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113 KGETSGN V S++ DCD D LL+ GP CH T +CF Sbjct: 73 VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCFTGRTISAN 123 >UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria RepID=HIS3_RALEJ Length = 135 Score = 158 bits (401), Expect = 9e-38, Method: Composition-based stats. Identities = 49/137 (35%), Positives = 72/137 (52%), Gaps = 4/137 (2%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + ++ ++ W+ +GL+PVIVQ + +VLM +MN +AL KT E G+ F+SR+++RL Sbjct: 1 MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120 W KGE SG+ V + DCD D +L+ + CH G SCF + Sbjct: 60 WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEG--DAESGDW 117 Query: 121 LLAERKSADPETSYTAK 137 E DP YTAK Sbjct: 118 QTVEPVLKDPSQIYTAK 134 >UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria RepID=HIS3_CHRSD Length = 146 Score = 157 bits (397), Expect = 2e-37, Method: Composition-based stats. Identities = 45/104 (43%), Positives = 62/104 (59%), Gaps = 1/104 (0%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 T W GL+P I Q SGEVLM+ +MN AL++TL +G+V ++SR++ + W Sbjct: 19 TRDLLDAARWNDA-GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106 KGE+SG +V+ DCD DTLL+ + GP CH G SCF Sbjct: 78 RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFY 121 >UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms RepID=HIS3_PSEU2 Length = 130 Score = 156 bits (396), Expect = 3e-37, Method: Composition-based stats. Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 3/130 (2%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + E+ W +DGL+P I Q +G VLM+ +MN EAL T + ++SR++ +LW Sbjct: 2 KDWLDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR 60 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLL 122 KGE SG+ + + DCD D ++++ IG CH G SCF ++ ++ +L Sbjct: 61 KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYR-VYEKSGWKTVDPVL 119 Query: 123 AERKSADPET 132 + + P Sbjct: 120 KDPDAIYPAG 129 >UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class) RepID=HIS3_CLAMS Length = 138 Score = 156 bits (396), Expect = 3e-37, Method: Composition-based stats. Identities = 46/107 (42%), Positives = 65/107 (60%), Gaps = 1/107 (0%) Query: 3 TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62 + + DGL+P ++Q + EVLMLGYM+ EAL +TL +G+VTF+SR++ W Sbjct: 16 VDGILARASF-ADDGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYW 74 Query: 63 TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109 KG+TSG+ V A DCD DT+LV + +G CH GT +CF Sbjct: 75 RKGDTSGHGQYVRDAALDCDGDTVLVQVDQVGVACHTGTRTCFDADH 121 >UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium HTCC2255 RepID=Q0FGM5_9RHOB Length = 120 Score = 156 bits (396), Expect = 3e-37, Method: Composition-based stats. Identities = 43/116 (37%), Positives = 63/116 (54%), Gaps = 1/116 (0%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 L ++ +GL+P +VQ + EVLM+ +MN +L+KT E+ TF+SR+++ LW KG Sbjct: 6 ISSLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGL 64 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122 TSGN V + DCD D +L+L P GP CH +CF + L Sbjct: 65 TSGNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTELEEGSENIILNPET 120 >UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria RepID=HIS3_ACIAC Length = 141 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 53/134 (39%), Positives = 69/134 (51%), Gaps = 11/134 (8%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 E+ W+ GL+PVI Q A +G+VLM +MN EAL KT E G+ +FSR++ RLW K Sbjct: 14 SWLDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFK 72 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 GE SG+ V I DCDND +L+ + G CH G SCF L Sbjct: 73 GEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFS------VLKDGAW 126 Query: 121 LLAERKSADPETSY 134 + DPE+ Y Sbjct: 127 QAVDPVLKDPESIY 140 >UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae RepID=HIS3_GLUOX Length = 156 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 2/124 (1%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 + + ++ ++ +GL+ + Q A G VLML +MN +AL +TL +G+V ++SR++Q+L Sbjct: 30 IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121 W KGETSG ++ DCD D +L++ + G CH G SCF + Sbjct: 88 WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYHGVTPDGLRDTSQPE 147 Query: 122 LAER 125 ++ Sbjct: 148 ISAE 151 >UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales RepID=HIS3_RHISN Length = 152 Score = 156 bits (395), Expect = 4e-37, Method: Composition-based stats. Identities = 46/129 (35%), Positives = 66/129 (51%), Gaps = 4/129 (3%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ GL+ +V A GE+LM+ +MN EAL T+E+G ++SR++ LW KGE+SGN Sbjct: 24 RFD-EKGLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGN 82 Query: 71 FLNVVSIAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 V I DCD D + + G TCH G SCF T ++ + E + Sbjct: 83 TQAVQEIRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARV-TITDEHRHF 141 Query: 129 DPETSYTAK 137 DP Y K Sbjct: 142 DPAQIYAEK 150 >UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria RepID=HIS3_BIFLI Length = 136 Score = 155 bits (393), Expect = 6e-37, Method: Composition-based stats. Identities = 44/105 (41%), Positives = 63/105 (60%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 GL+ ++Q + EVLM+GYMN EAL +TL +G+VTF+SR++Q W KG+TSG+ Sbjct: 22 RDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQ 81 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117 V ++ DCD D LLV + +G CH G SCF + + Sbjct: 82 YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 126 >UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides RepID=Q03VY1_LEUMM Length = 132 Score = 155 bits (392), Expect = 8e-37, Method: Composition-based stats. Identities = 49/125 (39%), Positives = 70/125 (56%), Gaps = 2/125 (1%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M+ + + + + +GL+P ++ A + LMLGYMN E+ T +G+ F+SR +Q Sbjct: 1 MIGTE--PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQE 58 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KGETSGN VVS+ DCD DTLL+ NP GP CH SCF +T + Sbjct: 59 LWHKGETSGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQA 118 Query: 121 LLAER 125 +A + Sbjct: 119 TIANK 123 >UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii 'Deep ecotype' RepID=B4RV64_ALTMD Length = 133 Score = 155 bits (392), Expect = 1e-36, Method: Composition-based stats. Identities = 46/112 (41%), Positives = 68/112 (60%), Gaps = 1/112 (0%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 ++ EL+++ DGL+PVI Q S +VLM +M+ E+LD+TL +GK+ ++SR++Q LW Sbjct: 20 DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL 115 KG +SG+ V SIA DCD D LL + +G CH SCF + Sbjct: 79 KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFYLRFWEDKVT 130 >UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae RepID=HIS3_METS3 Length = 132 Score = 154 bits (390), Expect = 1e-36, Method: Composition-based stats. Identities = 42/132 (31%), Positives = 67/132 (50%), Gaps = 5/132 (3%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 R E++ +K + I Q +G++LM+ MN +AL KT+E+GK ++S ++ W K Sbjct: 4 NFRHEINGQKV---ITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLK 60 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 GE+SG+ V I DCD D +++ G CH+G SCF + E+ L Sbjct: 61 GESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLET 120 Query: 125 --RKSADPETSY 134 K +P+ Y Sbjct: 121 ILEKVFNPDDVY 132 >UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms RepID=C7NRL7_HALUD Length = 138 Score = 154 bits (390), Expect = 2e-36, Method: Composition-based stats. Identities = 49/126 (38%), Positives = 69/126 (54%), Gaps = 10/126 (7%) Query: 9 ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68 +L +E + L P + Q A SG+VLML Y+ EALD+T E+G ++SR++ LW KGETS Sbjct: 22 DLAFEDNEYL-PAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETS 80 Query: 69 GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128 GN ++ I DCD D LL + G CH G SCF T ++ + + Sbjct: 81 GNVQHLKEIRVDCDGDALLYVIEQDGGACHTGFQSCFHRT---------IDGEVVGERVF 131 Query: 129 DPETSY 134 DP+ Y Sbjct: 132 DPDDVY 137 >UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria RepID=HIS3_BACCN Length = 101 Score = 153 bits (386), Expect = 5e-36, Method: Composition-based stats. Identities = 43/94 (45%), Positives = 61/94 (64%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 + GL+P IV + + EVLML YMN EA +KTL++ K F+SR++Q LW KG TSG+ +V Sbjct: 6 SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65 Query: 75 VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 S+ DCD D +++ N +G CH G +CF Sbjct: 66 KSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99 >UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C2AA Length = 132 Score = 153 bits (386), Expect = 5e-36, Method: Composition-based stats. Identities = 41/103 (39%), Positives = 59/103 (57%) Query: 4 EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 + DGL+P IVQ +G VLM+ +M+ AL T+ + + T++SR++ W Sbjct: 23 PADIANIAKFNADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWI 82 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106 KG TSG+F V S+A DCD DT+L+ G CH G+ SCF Sbjct: 83 KGLTSGHFQTVTSLALDCDGDTVLMQVVQDGAACHTGSHSCFD 125 >UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA Length = 126 Score = 152 bits (385), Expect = 5e-36, Method: Composition-based stats. Identities = 41/105 (39%), Positives = 59/105 (56%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+P I Q A +G VLML +MN EA D+T+ + +FSR++ +LW KG+TSG+ V I Sbjct: 21 LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80 Query: 78 APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122 DCD DT+L+ G CH+ SCF + E+ + Sbjct: 81 RVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERI 125 >UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria RepID=C7RQA3_9PROT Length = 142 Score = 152 bits (385), Expect = 6e-36, Method: Composition-based stats. Identities = 40/110 (36%), Positives = 64/110 (58%), Gaps = 1/110 (0%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + EL +++ GL+ I Q + E+LML +MN A+++TL +G ++SR+++ +W K Sbjct: 18 EVLDELAFDQ-QGLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114 GETSG V+ DCD D +L+L + +G CH G SSCF + Sbjct: 77 GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRNGRV 126 >UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13 RepID=B6BVA2_9PROT Length = 129 Score = 152 bits (385), Expect = 6e-36, Method: Composition-based stats. Identities = 51/131 (38%), Positives = 76/131 (58%), Gaps = 6/131 (4%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 ++ W GL+P I+Q S +V+M+ +MN EAL KT+E+ + F+SR++ ++W K Sbjct: 2 NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 GE SGNF NVVSI DCD D+LLV N G +CH G +SCF + + + + Sbjct: 61 GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120 Query: 124 ERKSADPETSY 134 + DP+ Y Sbjct: 121 K----DPKLIY 127 >UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI Length = 161 Score = 152 bits (384), Expect = 7e-36, Method: Composition-based stats. Identities = 47/133 (35%), Positives = 68/133 (51%), Gaps = 8/133 (6%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ +GL+PV+ A +GEVLM YMN EAL KT+E+G+ ++SR++Q+LW KG++SG Sbjct: 23 KFD-CNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGL 81 Query: 71 FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLA 123 V +A D D D L + G +CH G SCF Sbjct: 82 VQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTE 141 Query: 124 ERKSADPETSYTA 136 K+ DP+T Y Sbjct: 142 TEKTFDPKTVYGN 154 >UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41B27 Length = 137 Score = 150 bits (378), Expect = 4e-35, Method: Composition-based stats. Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 9/136 (6%) Query: 9 ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65 EL++ G L+ + Q + +VLM+ +MN EA+++TL++ K ++S ++Q+ W KG Sbjct: 2 ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61 Query: 66 ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL---- 121 E+SGN V + DCD D +++ + IG CH+G SCF L+ L Sbjct: 62 ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDED 121 Query: 122 --LAERKSADPETSYT 135 + + DP+ Y Sbjct: 122 ISIISERLFDPKEMYG 137 >UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RPU9_FIBSS Length = 116 Score = 150 bits (378), Expect = 4e-35, Method: Composition-based stats. Identities = 51/116 (43%), Positives = 68/116 (58%), Gaps = 5/116 (4%) Query: 1 MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57 M E +E+ +E G L P IVQ A G+VLM+ +MN EAL +T E G++ F+SR+ Sbjct: 1 MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60 Query: 58 KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111 ++ W KG+TSGN + VV A DCD+D LL GP CH G SCF T + Sbjct: 61 RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116 >UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria RepID=HIS3_MESSB Length = 139 Score = 150 bits (378), Expect = 4e-35, Method: Composition-based stats. Identities = 44/100 (44%), Positives = 61/100 (61%), Gaps = 3/100 (3%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ +GL+ +V A G +LM+ +MN EAL KTLE+G ++SR++ LW KGETSGN Sbjct: 27 RFD-ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGN 85 Query: 71 FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDT 108 +V SI+ DCD D +L+ G TCH G SCF Sbjct: 86 LQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRN 125 >UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae RepID=HIS3_PYRCJ Length = 128 Score = 149 bits (377), Expect = 5e-35, Method: Composition-based stats. Identities = 38/101 (37%), Positives = 60/101 (59%) Query: 8 RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67 + L++ G + +VQ +GEVLM+G+M+P A+ TL +G ++S +++R+W KGET Sbjct: 17 KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76 Query: 68 SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 SG++ V DCD D +++ IG CH G SCF Sbjct: 77 SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSP 117 >UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter necessarius RepID=B1XSV4_POLNS Length = 140 Score = 149 bits (377), Expect = 5e-35, Method: Composition-based stats. Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 2/103 (1%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 + W GL+PVI Q S ++LM+ +MN +AL +TL G+ +++R++Q+LW K Sbjct: 21 SWLDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHK 79 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106 GE SG+ V I DCD DT+L+L G CH G SCF Sbjct: 80 GEESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122 >UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G191_ABIDE Length = 295 Score = 149 bits (376), Expect = 6e-35, Method: Composition-based stats. Identities = 49/113 (43%), Positives = 66/113 (58%), Gaps = 1/113 (0%) Query: 7 RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66 ++ ++ GL+P IVQ +G VL + YMN E+L+ TL F+SR+++ LW KGE Sbjct: 18 IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76 Query: 67 TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119 TSGN+ +VVSI DCD D LLV G CH+G SCF DT +E Sbjct: 77 TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDTMKIEFEENIME 129 >UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales RepID=HIS3_MYCBP Length = 115 Score = 148 bits (375), Expect = 8e-35, Method: Composition-based stats. Identities = 41/107 (38%), Positives = 63/107 (58%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 M + + DGL+ +VQ SG+VLM+ +MN EAL +TL++ + T++SR++ Sbjct: 1 MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE 60 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107 W KG TSG+ +V S+ DCD D +L+ + +G CH G SCF Sbjct: 61 QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDA 107 >UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/ phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT Length = 127 Score = 148 bits (375), Expect = 9e-35, Method: Composition-based stats. Identities = 44/130 (33%), Positives = 66/130 (50%), Gaps = 5/130 (3%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 Q +L + GL+P ++ A G+ L L YMN +A+ KT+E+GK+ F R++ RL K Sbjct: 2 QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 GETSG+ +V I DC+ ++L+ + CH G SC+ + E Sbjct: 61 GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQTNSI----QVVE 116 Query: 125 RKSADPETSY 134 K DPE Y Sbjct: 117 EKVFDPENVY 126 >UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1 RepID=A3WCC9_9SPHN Length = 143 Score = 148 bits (375), Expect = 9e-35, Method: Composition-based stats. Identities = 47/98 (47%), Positives = 65/98 (66%), Gaps = 1/98 (1%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ GL+ +V + + EVL++ +MN +AL KT E+GKV F+SR++ LW KGETSGN Sbjct: 32 KFD-ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGN 90 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 L+V I DCD D L++ A P GPTCH G +SCF Sbjct: 91 VLSVDEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128 >UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales RepID=HIS3_ERYLH Length = 125 Score = 147 bits (372), Expect = 2e-34, Method: Composition-based stats. Identities = 45/98 (45%), Positives = 63/98 (64%), Gaps = 1/98 (1%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ +DGL+ +VQH + EVLM+ +MN +ALD T ++G FFSR++Q LW KG TSGN Sbjct: 18 KFD-SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGN 76 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 L V + DCD D +++L P GP CH G +CF Sbjct: 77 TLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE 114 >UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus ATCC 29799 RepID=A6P0M4_9BACE Length = 108 Score = 147 bits (371), Expect = 2e-34, Method: Composition-based stats. Identities = 50/97 (51%), Positives = 71/97 (73%), Gaps = 1/97 (1%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 ++K++ L+PVI+Q A + EVLMLG+ N EA++ TL++ F+SR++Q+LW KGETSG+F Sbjct: 8 FQKSE-LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHF 66 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 L+V + DCD DTLL +P+GPTCH G SCF Sbjct: 67 LHVERMVTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103 >UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ Length = 149 Score = 146 bits (369), Expect = 5e-34, Method: Composition-based stats. Identities = 50/133 (37%), Positives = 68/133 (51%), Gaps = 19/133 (14%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 +DGL+P IV A SG VLM +MN +AL +T+ +G F+SR++ +LW KGE SGN L+V Sbjct: 29 SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88 Query: 75 VSIAPDCDNDT--LLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132 + DCD D LL G CH G SCF R A P++ Sbjct: 89 KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR-----------------RLIASPDS 131 Query: 133 SYTAKLYASGTKR 145 S + L ++G Sbjct: 132 SGSLSLESAGLPL 144 >UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae RepID=HIS3_ZYMMO Length = 124 Score = 145 bits (365), Expect = 1e-33, Method: Composition-based stats. Identities = 36/102 (35%), Positives = 61/102 (59%), Gaps = 1/102 (0%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 W+ GL+ ++ A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ Sbjct: 15 WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73 Query: 72 LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113 + + I DCD DTL + P+GP CH G SCF Sbjct: 74 MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVEDGH 115 >UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris BL2 RepID=B8EQR3_METSB Length = 141 Score = 144 bits (364), Expect = 1e-33, Method: Composition-based stats. Identities = 42/106 (39%), Positives = 57/106 (53%), Gaps = 2/106 (1%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGL+ + + A GE+LM+ YMN EAL TL +G+ ++SR++Q +W KG TSG V Sbjct: 30 PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89 Query: 75 VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118 I DCD D LL + A G CH G SCF + + Sbjct: 90 REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYRRLSETGDGETV 135 >UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF76_THET1 Length = 300 Score = 141 bits (355), Expect = 2e-32, Method: Composition-based stats. Identities = 48/132 (36%), Positives = 76/132 (57%), Gaps = 8/132 (6%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64 L ++ GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W K Sbjct: 9 NLVDMLQYD-EHGLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLK 67 Query: 65 GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123 GETSG L+V + P+C+ ++LL+L + P CH G SCF + Sbjct: 68 GETSGRTLHVRELRPNCELNSLLILVDQRLPGACHTGHFSCFYRRLEDGELVE------I 121 Query: 124 ERKSADPETSYT 135 E DPE Y+ Sbjct: 122 EPPLFDPEDVYS 133 >UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001744401 Length = 141 Score = 139 bits (351), Expect = 6e-32, Method: Composition-based stats. Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 2/115 (1%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ DGL+P I + E LM+ YMN E L T+ G+ ++SR+++ +W KG+TSG Sbjct: 28 KFD-ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGE 86 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAE 124 F V I DCD D +++ +G CH +CF L+ Sbjct: 87 FQVVKEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRKVDLENVTAGPVPLVRA 141 >UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales RepID=HIS3_METVS Length = 136 Score = 135 bits (341), Expect = 7e-31, Method: Composition-based stats. Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 3/105 (2%) Query: 6 QRRELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 Q +L + K D L+ I VLM +M+ E+L TL++G + +FS ++ ++W Sbjct: 17 QNMDLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWM 75 Query: 64 KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108 KGE S N V+ + DCD D LL + G CH+G SCF + Sbjct: 76 KGEESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNK 120 >UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=HIS3_IGNH4 Length = 129 Score = 134 bits (337), Expect = 2e-30, Method: Composition-based stats. Identities = 36/106 (33%), Positives = 59/106 (55%), Gaps = 1/106 (0%) Query: 2 LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61 ++ L++ D + + Q SG+VLM+ MN EA+ KTL +G V ++S++++ L Sbjct: 8 EAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKEL 67 Query: 62 WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFG 106 W KG TSG+ + DCD D++L++ CH+G SCF Sbjct: 68 WVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFH 113 >UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZDC3_9SPHI Length = 130 Score = 131 bits (331), Expect = 1e-29, Method: Composition-based stats. Identities = 47/116 (40%), Positives = 66/116 (56%), Gaps = 7/116 (6%) Query: 12 WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71 +EK GL+PV+VQ SG+VLMLGY N AL +TL++G TF+S ++ LWTKG+TSG++ Sbjct: 15 FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74 Query: 72 LNVVSIAPDCDNDTLLVLANPIGP-TCHK------GTSSCFGDTAHQWLFLYQLEQ 120 L + I DCD D L+ +G CH SCF L +++ Sbjct: 75 LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCFYRKMASGKTLEFIDK 130 >UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58 RepID=Q1NG03_9SPHN Length = 157 Score = 130 bits (328), Expect = 2e-29, Method: Composition-based stats. Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 5/128 (3%) Query: 11 DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70 ++ +GLMP IV +A VLMLGYMN EAL +TL + + F+SR+++ LW KGE SG Sbjct: 22 RFD-AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGF 80 Query: 71 FLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQL---EQLLAERK 126 V + D D D L+++ P +CH G SCF + + + + Sbjct: 81 RQRVDHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDKSPVRLRRIEREA 140 Query: 127 SADPETSY 134 + D +T Y Sbjct: 141 AFDAKTVY 148 >UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein n=2 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=UPI0001910D6A Length = 157 Score = 129 bits (325), Expect = 6e-29, Method: Composition-based stats. Identities = 74/81 (91%), Positives = 77/81 (95%) Query: 1 MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR Sbjct: 77 MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136 Query: 61 LWTKGETSGNFLNVVSIAPDC 81 LWTKGETSG+ LNVVSIAPDC Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157 >UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira RepID=HIS3_LEPIN Length = 187 Score = 127 bits (320), Expect = 2e-28, Method: Composition-based stats. Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 13/133 (9%) Query: 9 ELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60 LD++KT L+PV+ G++LM + N E+ +L++G +FSR++ + Sbjct: 60 PLDFQKTTELLLTGKKNLVPVVAIDLQ-GQILMQAFGNEESQTLSLKTGYAHYFSRSRNQ 118 Query: 61 LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 LW KG+TSG+ ++ I D L+ CH+G SCF + + Sbjct: 119 LWKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERME----GVTWK 174 Query: 121 LLAERKSADPETS 133 LL ++ PE S Sbjct: 175 LLPVPRNFLPEKS 187 >UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae RepID=HIS3_SULSO Length = 85 Score = 124 bits (313), Expect = 1e-27, Method: Composition-based stats. Identities = 35/79 (44%), Positives = 49/79 (62%) Query: 33 MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92 M+G MN EAL KTL +G + F+S ++++LW KGETSGNF + DCD D +L Sbjct: 1 MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60 Query: 93 IGPTCHKGTSSCFGDTAHQ 111 +GP CH G +CF + + Sbjct: 61 LGPICHTGNYTCFYRSYDE 79 >UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SQK1_VERA1 Length = 699 Score = 123 bits (310), Expect = 3e-27, Method: Composition-based stats. Identities = 39/137 (28%), Positives = 66/137 (48%), Gaps = 14/137 (10%) Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132 ++ ++ DCDND + + G CH CFG+ + +LE+ L RK + PE Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNL----TGIARLEKTLKARKESAPEG 221 Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192 SYTA+L+ + K + K+ EE E A + ++ EA+DL+Y L G+ + Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDA---KTKEDVAFEAADLIYFALTKAVSAGVSVA 277 Query: 193 TVIENLR------KRHQ 203 + ++L KR + Sbjct: 278 DIEKSLDAKGWKVKRRK 294 >UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SHA6_LEPBA Length = 202 Score = 119 bits (298), Expect = 7e-26, Method: Composition-based stats. Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 1/108 (0%) Query: 13 EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72 + L P + Q ++G+ LML + E+L +ESG T+FSR++ W KGE SG+F Sbjct: 89 DSMPPLSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQ 147 Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120 + I + + + + IG CH G SCF Q + + Sbjct: 148 KLKQIYVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYS 195 >UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSK8_9BACT Length = 125 Score = 117 bits (294), Expect = 2e-25, Method: Composition-based stats. Identities = 47/103 (45%), Positives = 59/103 (57%), Gaps = 7/103 (6%) Query: 10 LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63 +D + + L+ V V M GYMN A++ TL G VTFFSRT +LW Sbjct: 20 VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79 Query: 64 KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105 KGETSGN L + I DCD D+LL+ A P+G TCH G+ SCF Sbjct: 80 KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCF 122 >UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD Length = 101 Score = 116 bits (291), Expect = 4e-25, Method: Composition-based stats. Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%) Query: 18 LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77 L+PV+V SG++LML Y + L+ T +G ++SR++Q +W KG +SG V ++ Sbjct: 7 LLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQLVQAV 66 Query: 78 APDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAH 110 DCD D L VL G CH SCF Sbjct: 67 YRDCDGDALNFRVLVLGDGRVCHTRQVSCFHTRLW 101 >UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms RepID=HIS2_PELTS Length = 98 Score = 116 bits (290), Expect = 6e-25, Method: Composition-based stats. Identities = 34/95 (35%), Positives = 50/95 (52%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + + L +++ +R+ P+ SYTA L+ G +I +K+GEE E +AA Sbjct: 1 MGEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAA 60 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L E +DL+YHLLVLL GL V+ L R Q Sbjct: 61 LVGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95 >UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria RepID=HIS2_CLOB1 Length = 110 Score = 115 bits (288), Expect = 1e-24, Method: Composition-based stats. Identities = 32/95 (33%), Positives = 51/95 (53%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 ++ + L ++ +RK E SYT L+ G +I +KVGEE E +AA D E Sbjct: 1 MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE 60 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L E DL YH++VL+ ++ + L + + L KR + Sbjct: 61 LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95 >UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria RepID=A6LT24_CLOB8 Length = 108 Score = 113 bits (282), Expect = 5e-24, Method: Composition-based stats. Identities = 32/90 (35%), Positives = 48/90 (53%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + L + + +RK+ E SYT L+ GT +I +KVGEE E ++ +++ E NE Sbjct: 3 ENIKALYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINE 62 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 DL YHLLVL+ + + V L KR Sbjct: 63 ICDLTYHLLVLMAQMNISIEEVGAELEKRR 92 >UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria RepID=HIS2_LEPBJ Length = 92 Score = 111 bits (279), Expect = 1e-23, Method: Composition-based stats. Identities = 48/91 (52%), Positives = 61/91 (67%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 FL QLE +L +RK P+ SYTA L+ G RI +KVGEE E +AA D+ ELT+ Sbjct: 1 MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH 60 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 EA+DL++HL VLL +Q L L V+E LRKRH Sbjct: 61 EAADLLFHLQVLLVEQELSLQDVVEELRKRH 91 >UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium RepID=HIS2_CLONN Length = 110 Score = 111 bits (279), Expect = 1e-23, Method: Composition-based stats. Identities = 29/95 (30%), Positives = 51/95 (53%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + +L ++ +RK E SYT L+ G +I +KVGEE E +AA ++ + Sbjct: 1 MDNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDD 60 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 L E D++YH++VL+ ++ + L + L KR + Sbjct: 61 LIAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95 >UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes RepID=HIS2_BACC2 Length = 107 Score = 111 bits (279), Expect = 1e-23, Method: Composition-based stats. Identities = 28/90 (31%), Positives = 49/90 (54%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L + + ERK + SYT L++ G +I +K+GEE E +A +D+ E+ E Sbjct: 3 NAFKLLYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKE 62 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 D+ YH VLL ++ + L V+ +++R+ Sbjct: 63 MVDVFYHCFVLLAEKNIALEDVMREVKERN 92 >UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5 Length = 105 Score = 111 bits (278), Expect = 1e-23, Method: Composition-based stats. Identities = 29/90 (32%), Positives = 51/90 (56%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 + +L ++ +RK + SYT L+ G +I +KVGEE E +A+ ++ + E Sbjct: 1 MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 DL+YH+LVL+ ++ + L + + L KR Q Sbjct: 61 CDLIYHVLVLMANENITLEELRKELEKRRQ 90 >UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria RepID=HIS2_MAGSA Length = 109 Score = 110 bits (276), Expect = 2e-23, Method: Composition-based stats. Identities = 42/92 (45%), Positives = 56/92 (60%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L +L ++A RK DP+ SYTAKL+A G +IAQK GEE VET +AA + EL Sbjct: 3 QDSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDEL 62 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E++D +YHLLVL D G++ V L +R Sbjct: 63 VGESADTLYHLLVLWADCGVEPAKVWAELARR 94 >UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales RepID=HIS2_BORA1 Length = 116 Score = 110 bits (275), Expect = 3e-23, Method: Composition-based stats. Identities = 28/74 (37%), Positives = 38/74 (51%) Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188 DP+TSY AKL A G +K+GEE E +AA + +E +DL +H LV L Sbjct: 29 DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88 Query: 189 LDLTTVIENLRKRH 202 L V+ L +R Sbjct: 89 LRPEDVLAELARRE 102 >UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum ATCC 11170 RepID=HIS2_RHORT Length = 117 Score = 109 bits (274), Expect = 4e-23, Method: Composition-based stats. Identities = 36/89 (40%), Positives = 52/89 (58%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + L ++A R+ ADP TSYTAKL+ G +I QK GEE E +AA V ++ E Sbjct: 15 EIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAE 74 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 ++D++YHL+VL D G+ V L +R Sbjct: 75 SADVLYHLMVLWADVGVTPDRVWAELARR 103 >UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria RepID=HIS2_NITMU Length = 121 Score = 109 bits (273), Expect = 6e-23, Method: Composition-based stats. Identities = 34/94 (36%), Positives = 49/94 (52%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 L++L + + RK +DP SY AKL G +I +K+ EE E LA+ D Sbjct: 1 MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH 60 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + E +DL +H LVLL L L V++ LR+R Sbjct: 61 VVRETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94 >UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria RepID=HIS2_NEIG1 Length = 107 Score = 108 bits (271), Expect = 1e-22, Method: Composition-based stats. Identities = 32/93 (34%), Positives = 48/93 (51%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L ++Q + +RKSADP SY A+L G +I +KV EE E +A+ D L Sbjct: 1 MGDSVLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHL 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 E +DL +H ++LL L V++ L +R Sbjct: 61 VYEVADLWFHTMILLTHHDLKAEDVLDELSRRQ 93 >UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei group RepID=HIS2_LACCB Length = 110 Score = 108 bits (270), Expect = 1e-22, Method: Composition-based stats. Identities = 29/94 (30%), Positives = 45/94 (47%) Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168 + L + ER++ SYT L+ G +I +KVGEE E +AA D Sbjct: 2 TQAKQSIPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPA 61 Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 E +DL YH+LVL+ ++G+ + + L R Sbjct: 62 FILEVADLTYHVLVLMVERGITVDQIATELASRE 95 >UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria RepID=HIS2_GRABC Length = 160 Score = 108 bits (270), Expect = 1e-22, Method: Composition-based stats. Identities = 35/96 (36%), Positives = 56/96 (58%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 D + L +L +++ +R+ ADP S++A+L + G ++AQK GEE VE + A D+ Sbjct: 38 DPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E++D++YHLLVL G++ V L KR Sbjct: 98 EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133 >UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus neapolitanus c2 RepID=D0KWI3_HALNC Length = 124 Score = 108 bits (269), Expect = 2e-22, Method: Composition-based stats. Identities = 44/95 (46%), Positives = 60/95 (63%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 T + L QL ++ +RK ADP +SY A+L+A G +IAQKVGEEGVE ALAA D Sbjct: 2 ATNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDN 61 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + +E +DL +H +VLL D GL V++ L +R Sbjct: 62 VAIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96 >UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms RepID=HIS2_ALHEH Length = 109 Score = 108 bits (269), Expect = 2e-22, Method: Composition-based stats. Identities = 36/91 (39%), Positives = 50/91 (54%) Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170 Q L L ++L ER+ ADP TSY AKL+ G I +KVGEE E +AA DR ++ Sbjct: 4 QRDILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVI 63 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +DL +H L++L V+ L +R Sbjct: 64 YETADLWFHSLIMLSACDAGPDDVLAELERR 94 >UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZNB1_9GAMM Length = 125 Score = 108 bits (269), Expect = 2e-22, Method: Composition-based stats. Identities = 31/82 (37%), Positives = 50/82 (60%) Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 +++ +R+ ADPE SY AKL+A G + +K+GEE ET +A D L +E +DL +H Sbjct: 20 EVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKNDDSDALVSEMADLWFH 79 Query: 180 LLVLLQDQGLDLTTVIENLRKR 201 L++L +G V++ L +R Sbjct: 80 SLIVLAARGRHPDDVLDELARR 101 >UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=B0MMD1_9FIRM Length = 114 Score = 107 bits (268), Expect = 2e-22, Method: Composition-based stats. Identities = 37/99 (37%), Positives = 58/99 (58%), Gaps = 5/99 (5%) Query: 110 HQWLFLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 + ++ +++ RK+ PE SYT L+ G +I +KVGEE ET +AA Sbjct: 1 MKMTVYEEIFEVIKARKAQYDAGNAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNA 60 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 D EL NE +DL+YH++VL D+GL+ + V E L +R++ Sbjct: 61 DNDELKNEINDLLYHVMVLCADRGLEWSEVEEVLSERNE 99 >UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ9_9ACTN Length = 105 Score = 106 bits (264), Expect = 6e-22, Method: Composition-based stats. Identities = 31/103 (30%), Positives = 49/103 (47%) Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159 G + + L L +++ R+ A P+ SYTA+L + +K+ EE E + Sbjct: 2 GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61 Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 A +D + EA DL+YHLLV L+ G+ L + L R Sbjct: 62 ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARR 104 >UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales RepID=HIS2_LEUMM Length = 114 Score = 106 bits (264), Expect = 6e-22, Method: Composition-based stats. Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 1/92 (1%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 + +L + ERK SYT LY G +I +KVGEE E L A ++ EL Sbjct: 1 MPQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EEL 59 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E SDL++HL+VLL ++G+ L + + L R Sbjct: 60 IYETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91 >UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic archaeon RC-I RepID=HIS2_UNCMA Length = 95 Score = 106 bits (264), Expect = 6e-22, Method: Composition-based stats. Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 2/93 (2%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELT 170 L ++ ++A+RK E SYT LY G ++ +K+GEE E +AA E+ Sbjct: 3 DVLDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIV 62 Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +E +DL +H +VLL + + + E +R + Sbjct: 63 SECADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95 >UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria RepID=HIS2_MAGSM Length = 252 Score = 106 bits (264), Expect = 7e-22, Method: Composition-based stats. Identities = 39/99 (39%), Positives = 52/99 (52%), Gaps = 2/99 (2%) Query: 105 FGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163 L Q+ Q++ +RKSA DPE SY AKL+ G I +KVGEE E LA Sbjct: 3 NLSPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKG 62 Query: 164 H-DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 R E+ +EA+DL++H LV L + T V+ L R Sbjct: 63 RAARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101 >UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria RepID=HIS2_ACIAC Length = 137 Score = 105 bits (263), Expect = 8e-22, Method: Composition-based stats. Identities = 33/112 (29%), Positives = 47/112 (41%), Gaps = 7/112 (6%) Query: 98 HKGTSSCFGDTAHQWLFLYQLEQLLAERKSA---DPETSYTAKLYASGTKRIAQKVGEEG 154 H S H L +L ++ RK A D + SY A+L G +K+GEE Sbjct: 3 HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62 Query: 155 VETALAATVHDRFE----LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 E +AA D L E +DL +H ++ L GL V+ L +R Sbjct: 63 TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114 >UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria RepID=HIS2_HALHL Length = 114 Score = 105 bits (262), Expect = 9e-22, Method: Composition-based stats. Identities = 31/97 (31%), Positives = 50/97 (51%) Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164 L L + + +R+ A +TSY A+L+ G I +KVGEE E +AA Sbjct: 4 AASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGG 63 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +R ++ E +DL +H LV+L G+ + V+ L +R Sbjct: 64 EREQVVYETADLWFHTLVMLSASGVSVDEVLAELERR 100 >UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria RepID=HIS2_ACICJ Length = 133 Score = 105 bits (262), Expect = 1e-21, Method: Composition-based stats. Identities = 34/96 (35%), Positives = 53/96 (55%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166 A L +L + RK+ADP S++A+L + G ++AQK GEE VE + A +R Sbjct: 14 PAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNR 73 Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E++D++YHLLV+ G+ V L++R Sbjct: 74 TALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109 >UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1 Tax=Raoultella terrigena RepID=Q6U8A9_KLETE Length = 88 Score = 105 bits (262), Expect = 1e-21, Method: Composition-based stats. Identities = 71/83 (85%), Positives = 75/83 (90%) Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL Sbjct: 6 LLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHL 65 Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203 +VLLQDQ L L +I NL+ RHQ Sbjct: 66 MVLLQDQELSLQDIIANLKSRHQ 88 >UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM 10642 RepID=C8SBH0_FERPL Length = 92 Score = 104 bits (261), Expect = 1e-21, Method: Composition-based stats. Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 L +L++++ ERK SYTAKL G ++ +K GEE VE LA D+ + Sbjct: 1 MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EA+DL+YH +VLL + + V + LR+R + Sbjct: 61 EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92 >UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta proteobacterium KB13 RepID=B6BVA1_9PROT Length = 104 Score = 104 bits (261), Expect = 2e-21, Method: Composition-based stats. Identities = 36/90 (40%), Positives = 59/90 (65%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 L +L+QL+ +K +DP SYTAKL++ G + I +K GEE +E +A+ ++ + N Sbjct: 1 MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E++D++YHLLVLL ++ + L VI L +R Sbjct: 61 ESADVLYHLLVLLSEKSVTLKEVISELERR 90 >UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis RepID=HIS2_ZYMMO Length = 107 Score = 104 bits (260), Expect = 2e-21, Method: Composition-based stats. Identities = 43/93 (46%), Positives = 57/93 (61%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L +E ++AER+ A PE SY + L+ GT IAQKVGEE VET +AA D+ L Sbjct: 1 MSEETLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSL 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +EA+DL++HL VLL D+G V LR+R Sbjct: 61 ESEAADLIFHLAVLLADRGSSFENVFSELRRRE 93 >UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei RepID=HIS2_IGNH4 Length = 102 Score = 104 bits (259), Expect = 2e-21, Method: Composition-based stats. Identities = 34/91 (37%), Positives = 54/91 (59%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 FL +L ++ +R P+ SYTA++ G A+K GEE VE +A+ R + E Sbjct: 3 DFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYE 62 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 A+D++YHL+VLL +G+D VI+ L +R + Sbjct: 63 AADVIYHLMVLLALRGVDWAEVIKELERRSR 93 >UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria RepID=HIS2_BURCC Length = 121 Score = 104 bits (259), Expect = 3e-21, Method: Composition-based stats. Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%) Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV---- 163 T L +L ++ RK DP+ SY ++L+ G + +K+GEE E LAA Sbjct: 2 TQSTEDTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQG 61 Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 L E +DL +H LV+L L VI L +R Sbjct: 62 GAPTALVGEVADLWFHCLVMLSHFDLSPADVIAELERRE 100 >UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ Length = 127 Score = 103 bits (257), Expect = 4e-21, Method: Composition-based stats. Identities = 37/96 (38%), Positives = 53/96 (55%) Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165 + L +L L+ R+S + SYTA+L +G +R A+K GEE VET +AA D Sbjct: 15 KEFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSD 74 Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 L EA+D +YHLLVLL+ + + V+ L R Sbjct: 75 ASALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110 >UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SM22_9BACT Length = 100 Score = 103 bits (256), Expect = 5e-21, Method: Composition-based stats. Identities = 28/92 (30%), Positives = 51/92 (55%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 + +L +++ ERK+ + SYT +L G+ +I +K+GEE E A D ++ Sbjct: 1 MNVEIIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDV 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E +DL+YHL+V L+ + + V+ L++R Sbjct: 61 AGETADLLYHLIVALEFRNVQFEDVLGVLQER 92 >UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae RepID=HIS2_METBF Length = 104 Score = 102 bits (254), Expect = 8e-21, Method: Composition-based stats. Identities = 32/90 (35%), Positives = 51/90 (56%), Gaps = 2/90 (2%) Query: 116 YQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 ++ +++ +RK E SY KL G +I +KVGEE +ET LA + E+ +E+ Sbjct: 10 NRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNENHEEIVSES 69 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 SDL++HLLV+L + L + L RH+ Sbjct: 70 SDLIFHLLVMLAANNVTLDEIAAELSARHE 99 >UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales RepID=HIS2_METB6 Length = 104 Score = 102 bits (254), Expect = 8e-21, Method: Composition-based stats. Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 8/108 (7%) Query: 98 HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGV 155 H+G + +L ++ ER E SYT++L G ++ +KVGEE Sbjct: 3 HEGKEPV------DLRVIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEEST 56 Query: 156 ETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 E LA T EA+DL +H+LV L+ +DL+ VI L +R + Sbjct: 57 EFILAVKNGVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104 >UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria RepID=HIS2_NITWN Length = 116 Score = 101 bits (253), Expect = 1e-20, Method: Composition-based stats. Identities = 36/96 (37%), Positives = 51/96 (53%) Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165 Q ++ L ++ R ++ + SYT KL G A+K+GEE VET +AA D Sbjct: 6 SRRIMQRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKD 65 Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 R L E +DLM+H LVLL+ G+ L V L +R Sbjct: 66 RHHLIAEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101 >UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae RepID=HIS22_BRAJA Length = 134 Score = 99.5 bits (247), Expect = 5e-20, Method: Composition-based stats. Identities = 27/90 (30%), Positives = 46/90 (51%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L +L + + DP TS TA+L+ G ++A+K+ EE +E + A D + E Sbjct: 3 DSLERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRE 62 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 ++DL+Y+L VL G+ V + +R Sbjct: 63 SADLLYNLTVLWASAGVRPEDVWREMTRRE 92 >UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha proteobacterium BAL199 RepID=A8TJZ9_9PROT Length = 104 Score = 99.2 bits (246), Expect = 7e-20, Method: Composition-based stats. Identities = 30/91 (32%), Positives = 50/91 (54%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + +L + + ++ P S TA+L G +IA+KV EE E AL A V DR + E Sbjct: 3 HPIDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRE 62 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 ++DL+Y+L+VL G+ + V + +R + Sbjct: 63 SADLLYNLMVLWVWMGITPSEVWAEMEQREK 93 >UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FUB9_METHJ Length = 91 Score = 98.8 bits (245), Expect = 1e-19, Method: Composition-based stats. Identities = 25/90 (27%), Positives = 50/90 (55%), Gaps = 2/90 (2%) Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + ++ ++ ER + E SYT+K+ G + +K+GEE E +A D+ ++ E Sbjct: 1 MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL++H ++ L+ G+ L +V + L+ R Sbjct: 61 GADLLFHFMLALKRSGVTLQSVWDELQSRR 90 >UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing symbionts RepID=HIS2_VESOH Length = 105 Score = 98.8 bits (245), Expect = 1e-19, Method: Composition-based stats. Identities = 30/85 (35%), Positives = 48/85 (56%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +LEQ+L +RKSA + SY + LY GT I +K+ EE E +A ++ E +DL Sbjct: 7 KLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEIADL 66 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201 +H LVLL+ + + + + L +R Sbjct: 67 WFHTLVLLRFKKIKVEQITNELSRR 91 >UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria RepID=HIS2_BRUA1 Length = 107 Score = 98.4 bits (244), Expect = 1e-19, Method: Composition-based stats. Identities = 40/92 (43%), Positives = 57/92 (61%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L LE+++AER S TSYTA L A G + AQK+GEE VET +AA DR + Sbjct: 1 MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +E++DL+YHL V+ G+ L V++ L++R Sbjct: 61 VSESADLLYHLAVVWNIAGVALEDVLQELQRR 92 >UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales RepID=HIS2_MESSB Length = 112 Score = 98.4 bits (244), Expect = 1e-19, Method: Composition-based stats. Identities = 36/92 (39%), Positives = 57/92 (61%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L +LE ++AER ++ S+TA+L ++G + A+K+GEE VET +AA D+ L Sbjct: 1 MNEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKAL 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 E++DL+YH LV+L+ G+ L V+ L R Sbjct: 61 IAESADLVYHWLVVLKIAGVRLDEVMLELESR 92 >UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae RepID=Q2CDY7_9RHOB Length = 106 Score = 97.2 bits (241), Expect = 3e-19, Method: Composition-based stats. Identities = 34/82 (41%), Positives = 50/82 (60%), Gaps = 1/82 (1%) Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179 + +A RK ADP+ S+TA+L AS + A+K GEE VE + A DR L +EA+D++YH Sbjct: 8 ETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSEAADVIYH 66 Query: 180 LLVLLQDQGLDLTTVIENLRKR 201 LLV+ + L + L +R Sbjct: 67 LLVMCAVNDITLADIERELERR 88 >UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis HTCC2503 RepID=A3VQS9_9PROT Length = 109 Score = 97.2 bits (241), Expect = 3e-19, Method: Composition-based stats. Identities = 38/89 (42%), Positives = 48/89 (53%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 L +L + RK AD SYTA L G R A+K GEE VE ALA + R +L E Sbjct: 7 TLERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAET 66 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +D++YHL VLL LD + + L KR Sbjct: 67 ADVLYHLAVLLAANELDWSDISAALTKRE 95 >UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae RepID=HIS2_NATPD Length = 101 Score = 96.9 bits (240), Expect = 3e-19, Method: Composition-based stats. Identities = 38/98 (38%), Positives = 55/98 (56%), Gaps = 2/98 (2%) Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVH 164 D L +L +++ RK P+ SYTA L+ G + +K+GEE E LAA Sbjct: 4 DGHDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDD 63 Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 D EL +EA+D++YHLLVLL + ++L + LRKR Sbjct: 64 DDEELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101 >UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae RepID=A4SV22_POLSQ Length = 133 Score = 96.5 bits (239), Expect = 5e-19, Method: Composition-based stats. Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%) Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV--------HDRFELTNEASDLMY 178 SADP+TSYTA L++ G I +K+GEE E +AA + L E +DL + Sbjct: 33 SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92 Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201 H L+ L L VI L +R Sbjct: 93 HCLIALSQFNLRPEDVIAELDRR 115 >UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota RepID=HIS2_META3 Length = 96 Score = 94.9 bits (235), Expect = 1e-18, Method: Composition-based stats. Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 4/96 (4%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRF 167 L + +++ +R PE SY A L + +I +KVGEE ET LAA D+ Sbjct: 1 MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ 60 Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EL E++DL++H+LVLL + G++ ++E +R + Sbjct: 61 ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK 96 >UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp. HTCC2601 RepID=Q0FX88_9RHOB Length = 164 Score = 93.4 bits (231), Expect = 4e-18, Method: Composition-based stats. Identities = 30/65 (46%), Positives = 39/65 (60%) Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74 DGLMP A SGE+LMLG+M EA T+E+G+ +FSR +Q LW +G SG L + Sbjct: 12 PDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKL 71 Query: 75 VSIAP 79 V Sbjct: 72 VEARI 76 >UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis RepID=HIS2_SPHAL Length = 109 Score = 93.0 bits (230), Expect = 6e-18, Method: Composition-based stats. Identities = 39/91 (42%), Positives = 54/91 (59%), Gaps = 1/91 (1%) Query: 113 LFLYQLEQLLAERKSADP-ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 L +LE ++ +R +A E SY A L A G +IAQK+GEE VE +AA D L Sbjct: 7 ETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIG 66 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 EASDL++HL +LL ++GL + L +RH Sbjct: 67 EASDLVFHLSILLAERGLTWDAIAAELDRRH 97 >UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K RepID=B4UDK1_ANASK Length = 110 Score = 92.2 bits (228), Expect = 1e-17, Method: Composition-based stats. Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 6/90 (6%) Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNE 172 + + R A P SYT KL A+ RI +K+ EE E A + L +E Sbjct: 11 WATIESRRADAAPAESYTKKLLAA-PARIRRKIIEEAYEVNEAHQALLDGKDTKDHLAHE 69 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 A+DL+YHL VLL + T V L +RH Sbjct: 70 AADLLYHLYVLLASADVTPTEVYGVLERRH 99 >UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB Length = 101 Score = 90.7 bits (224), Expect = 2e-17, Method: Composition-based stats. Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 L + +RK+ D + SYT+ L + G + K+ EE E A +D+ + +EA+D Sbjct: 7 NLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHEAADT 64 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +YH+LV L+ + V++ L R + Sbjct: 65 IYHILVTLEAADIKFEDVLKELEGRKK 91 >UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae RepID=Q0C645_HYPNA Length = 120 Score = 89.5 bits (221), Expect = 7e-17, Method: Composition-based stats. Identities = 31/104 (29%), Positives = 45/104 (43%) Query: 99 KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158 + + E + A D +S+TAKL A G A KV EEG E A Sbjct: 2 TAKAPLASPDRLAAALAHLAETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELA 61 Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 A + +EA+D++YH+ V L+ +G+ L V L R Sbjct: 62 DAVRRESDDRVASEAADVIYHVFVALRSRGVALDAVAGALEARQ 105 >UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces RepID=HIS2_STRCO Length = 90 Score = 88.8 bits (219), Expect = 1e-16, Method: Composition-based stats. Identities = 26/76 (34%), Positives = 39/76 (51%) Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182 + + DP TS TA+L G I +KV EE E +AA + E S L+YH+ V Sbjct: 15 HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74 Query: 183 LLQDQGLDLTTVIENL 198 ++ +G+ L V +L Sbjct: 75 MMVARGISLDDVYAHL 90 >UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales RepID=HIS2_STRGG Length = 90 Score = 88.4 bits (218), Expect = 1e-16, Method: Composition-based stats. Identities = 26/75 (34%), Positives = 38/75 (50%) Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183 + DP TS TA+L G I +KV EE E +AA + E S L+YH+ V+ Sbjct: 16 KAAEGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVM 75 Query: 184 LQDQGLDLTTVIENL 198 + +G+ L V +L Sbjct: 76 MVARGISLDDVYAHL 90 >UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani RepID=HIS2_CLOTE Length = 107 Score = 86.8 bits (214), Expect = 4e-16, Method: Composition-based stats. Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 3/93 (3%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 + L + + + + D SY L+ + +I +K+GE+ E +A + E Sbjct: 1 MEVNKLIEELVEVIKDRKNDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQ 57 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +E SDL+Y+L+VL+ Q +++ VIE L KR Sbjct: 58 VHEISDLIYNLMVLMMKQNIEIENVIEELGKRR 90 >UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria RepID=Q4JVP0_CORJK Length = 332 Score = 85.3 bits (210), Expect = 1e-15, Method: Composition-based stats. Identities = 27/91 (29%), Positives = 38/91 (41%) Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167 + L L+ R PE S T K +G +K+ EE E LAA Sbjct: 242 NEQELKTFDSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDE 301 Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198 EL E S L+Y L V++ +GL + + L Sbjct: 302 ELAEEISQLLYWLQVVMVGRGLTPADIYKYL 332 >UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RQ70_FIBSS Length = 86 Score = 84.1 bits (207), Expect = 3e-15, Method: Composition-based stats. Identities = 25/86 (29%), Positives = 43/86 (50%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 + ++ L +RK PE T +L+ G I +K+ EE E+ +AA R E Sbjct: 1 MTFEEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLE 60 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198 S ++Y++ V++ ++GL L V L Sbjct: 61 LSQVLYYVAVMMAEKGLTLEEVYAKL 86 >UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQN9_9RICK Length = 103 Score = 83.8 bits (206), Expect = 3e-15, Method: Composition-based stats. Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%) Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171 + L L + + ERK++ SYT KL + +KV EE E A +++ + Sbjct: 2 FEVLEGLIKTIRERKNSSEHESYTKKLLDN-NSLCREKVMEEIKELVEAL--NEKKNEVH 58 Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 EA+D+MYH+LVLL+ + + V+ L+KR Sbjct: 59 EAADVMYHILVLLEANNVKVEDVMNELKKRE 89 >UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD Length = 253 Score = 82.2 bits (202), Expect = 9e-15, Method: Composition-based stats. Identities = 30/80 (37%), Positives = 50/80 (62%) Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180 ++ + +S + S+T K+ A G +I +KVGEE VE LA D + +EA+D++YH+ Sbjct: 56 IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115 Query: 181 LVLLQDQGLDLTTVIENLRK 200 L+LL GL L T+ + +R+ Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135 >UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium RepID=C4L178_EXISA Length = 102 Score = 82.2 bits (202), Expect = 1e-14, Method: Composition-based stats. Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%) Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173 +++LEQL+ RK E SYT L+ G ++IA+K GEE E +AA +L E+ Sbjct: 1 MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58 Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 +DL+YHLLVLL +G+ L V L KRH Sbjct: 59 ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87 >UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae RepID=HIS2_RHOBA Length = 120 Score = 81.8 bits (201), Expect = 1e-14, Method: Composition-based stats. Identities = 33/90 (36%), Positives = 45/90 (50%), Gaps = 3/90 (3%) Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172 +L L R + PE SYT KL G + I +K+ EE E AA D R E Sbjct: 9 DRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHAIYE 68 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 A DL+YH +VL+ +G++L V L +R Sbjct: 69 AGDLIYHAMVLMAWRGIELDEVAAELARRE 98 >UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK Length = 90 Score = 81.8 bits (201), Expect = 1e-14, Method: Composition-based stats. Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L L +L +RKS+ E SYT KL KV EE E A + +E Sbjct: 3 NTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--IHE 59 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 A+D+ YHLL+ L+ + + V++ L R + Sbjct: 60 AADVFYHLLMYLEANDVKIEEVMQELENRKK 90 >UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae RepID=HIS2_METS5 Length = 93 Score = 81.4 bits (200), Expect = 1e-14, Method: Composition-based stats. Identities = 38/91 (41%), Positives = 55/91 (60%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L +L ++A+R PE SYTA L G +A+KVGEE VE +A+ R + +E Sbjct: 3 DVLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSE 62 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 +DL+YHLLVLL +G+ L V + LR+R + Sbjct: 63 TADLIYHLLVLLAMEGISLDEVRDELRRRMK 93 >UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae RepID=HIS2_METS3 Length = 96 Score = 80.7 bits (198), Expect = 3e-14, Method: Composition-based stats. Identities = 25/86 (29%), Positives = 43/86 (50%), Gaps = 6/86 (6%) Query: 121 LLAERKSADPETSYTAKLYA----SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 + E + +P SYT+K+ +I +KV EE E LAA L E+ DL Sbjct: 12 KVLEERRDNPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND--ENLVYESVDL 69 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202 ++H L++L +G+++ + E +R Sbjct: 70 IFHTLLILVYKGIEIDEIFEEFARRR 95 >UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis RepID=B9RGV5_RICCO Length = 193 Score = 80.3 bits (197), Expect = 4e-14, Method: Composition-based stats. Identities = 24/105 (22%), Positives = 44/105 (41%), Gaps = 7/105 (6%) Query: 103 SCFGDTAHQWLFLYQLEQLLAERKSADPET-----SYTAKLYASGTKRIAQKVGEEGVET 157 LY LE +++RK+ S+T +L + K+ EE E Sbjct: 74 GAVQGKRLALTTLYSLESTISQRKAELAAPQEGKPSWTRRLL-DDPNLLCSKIREEADEL 132 Query: 158 ALAATVHDRF-ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 ++ +E D++YH +VLL + + + V++ LR+R Sbjct: 133 CRTLEENEHSIHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177 >UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria RepID=HIS2_MYCLB Length = 93 Score = 78.7 bits (193), Expect = 1e-13, Method: Composition-based stats. Identities = 27/86 (31%), Positives = 35/86 (40%) Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172 L L+ER P S T G + +K+ EE E LAA + L E Sbjct: 8 KTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEE 67 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198 S L+Y VL+ +GL L V L Sbjct: 68 ISQLLYWTQVLMISRGLSLDDVYRKL 93 >UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZIN5_PLALI Length = 98 Score = 78.4 bits (192), Expect = 2e-13, Method: Composition-based stats. Identities = 24/89 (26%), Positives = 43/89 (48%), Gaps = 3/89 (3%) Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172 +LE L R P SY +L +G +A + E+ + A D ++ Sbjct: 6 KRLEAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPAA 65 Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 A+++++H ++LL+ G DL+TV L +R Sbjct: 66 AANVLFHWMLLLKAYGHDLSTVERELMQR 94 >UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales RepID=Q0F926_9RHOB Length = 105 Score = 77.2 bits (189), Expect = 3e-13, Method: Composition-based stats. Identities = 32/86 (37%), Positives = 55/86 (63%) Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176 +L Q + RK+ E SY ++L SG+++ A+K GEE VE +AA D+ LT E++D+ Sbjct: 7 RLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEESADV 66 Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202 ++H+LV+L +D +V++ L +R Sbjct: 67 LFHMLVMLSSCDVDFKSVLKELERRE 92 >UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243 RepID=C8WMR5_EGGLE Length = 163 Score = 76.4 bits (187), Expect = 5e-13, Method: Composition-based stats. Identities = 34/134 (25%), Positives = 48/134 (35%), Gaps = 35/134 (26%) Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161 S ++ L +A R+ A E SYT +L + +KV EE ETALAA Sbjct: 9 SGEMPPSSQIGATFEALAATIAARREAG-EESYTYRLLTGSLDGVLKKVMEEAGETALAA 67 Query: 162 TVHDR----------------------------------FELTNEASDLMYHLLVLLQDQ 187 + L EA+D++YHLLV+L+ Sbjct: 68 KDVESWACSSLAASIAASGAVDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERY 127 Query: 188 GLDLTTVIENLRKR 201 G+ L L R Sbjct: 128 GIGLDEFAAELNNR 141 >UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GPL2_9DELT Length = 978 Score = 71.4 bits (174), Expect = 2e-11, Method: Composition-based stats. Identities = 19/106 (17%), Positives = 40/106 (37%), Gaps = 7/106 (6%) Query: 98 HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVET 157 H + + + ++ E+ +S + + + QK+ EE E Sbjct: 4 HSNSHPIYYYKLVRDKIP----SIIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYEL 56 Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 A D+ + E+SD++ L +L+ Q ++ L KR + Sbjct: 57 FTAIANGDKESVLKESSDVLEITLTILKQQNYSFDDLLAELEKRRE 102 >UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria RepID=HIS2_METS4 Length = 107 Score = 63.7 bits (154), Expect = 4e-09, Method: Composition-based stats. Identities = 40/92 (43%), Positives = 59/92 (64%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L L++++ R +A P+ SYTAKL A+G + A+K+GEE VE A+AA DR L Sbjct: 1 MTAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGL 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 +EA+D++YHLLV+L G+ L V+ L +R Sbjct: 61 VSEAADVLYHLLVVLVGSGVALEDVMAELERR 92 >UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Streptococcus mutans RepID=Q8DTR6_STRMU Length = 61 Score = 59.1 bits (142), Expect = 9e-08, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 25/46 (54%) Query: 157 TALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202 + A D+ E+ +E +DL+YHL V+L + G+ V L+ R Sbjct: 1 MVIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46 >UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium longum DJO10A RepID=UPI00003932E2 Length = 68 Score = 58.7 bits (141), Expect = 1e-07, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 21/45 (46%) Query: 73 NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117 V ++ DCD D LLV + +G CH G SCF + + Sbjct: 19 YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 63 >UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium retbaense DSM 5692 RepID=C8X332_DESRD Length = 979 Score = 58.7 bits (141), Expect = 1e-07, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 27/56 (48%) Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 QK+ EE E V ++ + E++D++ +L +L+ G +I + R + Sbjct: 47 QKLLEEAYELFTEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102 >UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ Length = 303 Score = 54.1 bits (129), Expect = 3e-06, Method: Composition-based stats. Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 4/65 (6%) Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196 ++ KV EE E A A D ++ E DL++ + L + G+D T + Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALRDGTA 259 Query: 197 NLRKR 201 +R Sbjct: 260 KFERR 264 Score = 39.1 bits (90), Expect = 0.089, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 22/59 (37%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----NLRKRH 202 EE E A A D +L +E DL+ +H + + V L +RH Sbjct: 60 EEAYEVADAVARGDLRDLRDELGDLLLQVVFHARMAEEQGAFAFDDVARAIGDKLVRRH 118 >UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U6I7_HYDS0 Length = 251 Score = 53.3 bits (127), Expect = 4e-06, Method: Composition-based stats. Identities = 16/63 (25%), Positives = 30/63 (47%), Gaps = 4/63 (6%) Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENL 198 + +A+ V EE E A D+ + E +DL+ +H + +++ D+ V E L Sbjct: 27 HESLAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVFELL 86 Query: 199 RKR 201 K+ Sbjct: 87 IKK 89 >UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SG07_9BACT Length = 257 Score = 51.4 bits (122), Expect = 2e-05, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 27/65 (41%), Gaps = 8/65 (12%) Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVIEN---- 197 I EE E A D + E D+ +H++ V+ +++G + V+ Sbjct: 32 IKNHFMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVLNEINEK 91 Query: 198 LRKRH 202 L +RH Sbjct: 92 LIRRH 96 Score = 42.9 bits (100), Expect = 0.006, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 21/60 (35%) Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 K EE E A + E+ +E D+ + L+ L + ++ + R Sbjct: 160 DMHGCMDKFNEEINEFKEAVATGSKDEIEHEMGDVFFSLINLSRFLKINPDEALRRANSR 219 >UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone 'Hot96_1+Hot96_2' RepID=UPI0001699CB9 Length = 128 Score = 51.4 bits (122), Expect = 2e-05, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 5 QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39 + ++ W+ +GL+P I Q +G++LM+ +MN Sbjct: 3 EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36 >UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae RepID=HIS2_PYRIL Length = 94 Score = 51.0 bits (121), Expect = 2e-05, Method: Composition-based stats. Identities = 39/94 (41%), Positives = 54/94 (57%) Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169 L +LE+++ R SYT +LY+SG +A+KVGEE VE A+AA + + Sbjct: 1 MSCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRI 60 Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203 EA+DL+YHLLVLL GL L V L +R + Sbjct: 61 VEEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94 >UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RLE1_FIBSS Length = 265 Score = 47.5 bits (112), Expect = 2e-04, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 26/67 (38%), Gaps = 8/67 (11%) Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENL- 198 + + EE E AA D+ + E D++ +H V + + VI+ L Sbjct: 30 HSLLPYLVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVIQGLC 89 Query: 199 ---RKRH 202 +RH Sbjct: 90 EKMVRRH 96 >UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide pyrophosphohydrolase domain fusion protein n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT Length = 258 Score = 47.5 bits (112), Expect = 3e-04, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%) Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195 + + + EE E A D EL +E DL+ +H + +++ + V Sbjct: 27 EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86 Query: 196 E----NLRKRH 202 + + +RH Sbjct: 87 QNISEKMIRRH 97 >UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria RepID=A8I3U9_AZOC5 Length = 283 Score = 47.2 bits (111), Expect = 4e-04, Method: Composition-based stats. Identities = 11/56 (19%), Positives = 25/56 (44%) Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 + + + K+ EE E + A + +E DL++ ++ L + G+D + Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALR 230 >UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6 Tax=Bacteria RepID=Q3AFK8_CARHZ Length = 479 Score = 47.2 bits (111), Expect = 4e-04, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 8/65 (12%) Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----EN 197 + V EE E A A D +L E DL+ +H + ++ V+ E Sbjct: 258 LLPYVLEEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVVEGICEK 317 Query: 198 LRKRH 202 L +RH Sbjct: 318 LIRRH 322 >UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A3P2_NATTJ Length = 384 Score = 46.0 bits (108), Expect = 7e-04, Method: Composition-based stats. Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 4/54 (7%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR 199 + EE E A + + E DL+ +H V + L V+ L+ Sbjct: 143 LIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVLTKLK 196 >UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D9Q9_9ACTN Length = 336 Score = 46.0 bits (108), Expect = 7e-04, Method: Composition-based stats. Identities = 18/68 (26%), Positives = 26/68 (38%), Gaps = 8/68 (11%) Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTV---- 194 + I + + EE E A D L E D++ H + L +Q L V Sbjct: 58 HESITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVCHGL 117 Query: 195 IENLRKRH 202 E L +RH Sbjct: 118 AEKLIRRH 125 >UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GIZ4_9FIRM Length = 481 Score = 45.6 bits (107), Expect = 9e-04, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%) Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195 + + EE E A D +L E DL+ +H + ++Q ++ Sbjct: 250 EQDHHSLKPYLLEEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIV 309 Query: 196 E----NLRKRH 202 L +RH Sbjct: 310 AGITEKLVRRH 320 >UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase domains n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NET9_KYTSD Length = 144 Score = 45.6 bits (107), Expect = 9e-04, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 22/61 (36%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVIENLR----KR 201 V EE E A D L E DL++ H + + + V+ L +R Sbjct: 42 VLEEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVVAELEAKLLRR 101 Query: 202 H 202 H Sbjct: 102 H 102 >UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD Length = 396 Score = 45.6 bits (107), Expect = 0.001, Method: Composition-based stats. Identities = 13/60 (21%), Positives = 24/60 (40%) Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201 + K+ EE E A +DR + +E D+++ L L + G + +R Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234 >UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PZU0_9BACT Length = 283 Score = 45.6 bits (107), Expect = 0.001, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 26/61 (42%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI----ENLRKR 201 + EE E A +L E +DL ++H + + + D+ V+ + + +R Sbjct: 57 LVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVMKLCLDKMMRR 116 Query: 202 H 202 H Sbjct: 117 H 117 >UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM Length = 264 Score = 45.2 bits (106), Expect = 0.001, Method: Composition-based stats. Identities = 18/72 (25%), Positives = 27/72 (37%), Gaps = 8/72 (11%) Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV 194 IA+ EE E + +D L E DL+YH+L + + V Sbjct: 28 LQQNFASIAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDV 87 Query: 195 IENLR----KRH 202 I+ L +RH Sbjct: 88 IQQLAAKLIRRH 99 >UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9 Length = 302 Score = 45.2 bits (106), Expect = 0.001, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 4/65 (6%) Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196 + + + KV EE E A E+ E DL++ + L + +D I Sbjct: 200 ADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIRSTNA 259 Query: 197 NLRKR 201 +R Sbjct: 260 KFERR 264 >UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frankia sp. CcI3 RepID=Q2J4X9_FRASC Length = 116 Score = 45.2 bits (106), Expect = 0.001, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 34/93 (36%) Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165 +L LAE+ S T G + +K+ EE E +AA Sbjct: 24 SSNVSNLKTFDELFVELAEKWRRRTPGSGTVAALDQGVHHLGKKLVEEAAEAWMAAEHEG 83 Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198 R E S L+Y +L+ GL L V +L Sbjct: 84 RGRAAEEISQLLYWSQLLMISLGLSLDDVYSHL 116 >UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=Actinomycetales RepID=A4F800_SACEN Length = 334 Score = 44.8 bits (105), Expect = 0.002, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 21/66 (31%), Gaps = 8/66 (12%) Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDL---T 192 + + + EE E A DR L E D +++H + + D Sbjct: 125 EQDHDTLRKYLVEETYELLDAIEQRDRDALREELGDVLLQVLFHARIA-AEHDADPFGVD 183 Query: 193 TVIENL 198 V L Sbjct: 184 EVAAEL 189 >UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF Length = 289 Score = 44.8 bits (105), Expect = 0.002, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 8/59 (13%) Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202 EE E A A D ++ E D++ +H + + Q DL VI L +RH Sbjct: 59 EEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRH 117 >UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LC99_MAGSM Length = 277 Score = 44.8 bits (105), Expect = 0.002, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 25/55 (45%) Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196 T I K+ EE E A A +DR E DL++ L+ L + ++ T + Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233 >UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640_PELTS Length = 582 Score = 44.8 bits (105), Expect = 0.002, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%) Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195 + + + EE E A D ++ E DL+ +H + +++ D+ VI Sbjct: 345 EQDHRTLKPYLLEEAYEVIEALDEEDMYKTCEELGDLLLQIVFHAQIAAENRHFDINDVI 404 Query: 196 E----NLRKRH 202 + +RH Sbjct: 405 AGISEKMIRRH 415 >UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX RepID=Q47SV3_THEFY Length = 246 Score = 44.5 bits (104), Expect = 0.002, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 28/70 (40%), Gaps = 10/70 (14%) Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQD--QGLDLTTV-- 194 + +A+ + EE ET D L E D++ +H V + G + V Sbjct: 35 HESLAKYLIEEAYETVETIERGDYDTLAEELGDVLLQVVFHARVAAERGPDGFTIDDVAD 94 Query: 195 --IENLRKRH 202 I+ L +RH Sbjct: 95 AIIDKLVRRH 104 >UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CGC7_KOSOT Length = 256 Score = 43.7 bits (102), Expect = 0.004, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 23/61 (37%), Gaps = 8/61 (13%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201 + EE E A + E E DL+ +H + + + V+ + L +R Sbjct: 38 LIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVVETLSDKLIRR 97 Query: 202 H 202 H Sbjct: 98 H 98 >UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces RepID=D1X3V9_9ACTO Length = 335 Score = 43.7 bits (102), Expect = 0.004, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 31/79 (39%), Gaps = 13/79 (16%) Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG- 188 +T++ G +A+ EE E A DR EL E D++ +H + +D Sbjct: 147 WTSRKTHRG---LAKYAIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEDPDE 203 Query: 189 -LDLTTVI----ENLRKRH 202 + V E L RH Sbjct: 204 PFAVDDVAGGLVEKLIHRH 222 >UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepID=C8XKR8_NAKMY Length = 240 Score = 43.3 bits (101), Expect = 0.005, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 26/69 (37%), Gaps = 12/69 (17%) Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQ----DQGLDLTTVI-- 195 + + + EE E A DR + E D +++H + + G D+ V Sbjct: 40 LVRYLLEECYELVEAVESGDRAAIREELGDVLLQVLFHARIAAETPRDQGGFDIDDVAGD 99 Query: 196 --ENLRKRH 202 L +RH Sbjct: 100 LVAKLVRRH 108 >UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Streptomyces RepID=C9N950_9ACTO Length = 328 Score = 42.9 bits (100), Expect = 0.006, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 10/73 (13%) Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTT 193 + +A+ EE E A DR EL E D++ +H + +DQ + Sbjct: 140 QKTHQGLAKYAIEEAYELVEAIEDGDREELREELGDVLLQVVFHARIAQEDQEEPFGIDD 199 Query: 194 VIE----NLRKRH 202 V L RH Sbjct: 200 VAATIVEKLIHRH 212 >UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL Length = 180 Score = 42.9 bits (100), Expect = 0.006, Method: Composition-based stats. Identities = 12/51 (23%), Positives = 21/51 (41%) Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200 + EE E + A L E +D++Y G+DL V+ + + Sbjct: 85 LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135 >UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC0_DESHD Length = 493 Score = 42.9 bits (100), Expect = 0.007, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 24/68 (35%), Gaps = 8/68 (11%) Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI--- 195 + + EE E A D + L E DL+ +H V + V+ Sbjct: 252 HDSLKPYLIEESYEVLEAIEAQDMYNLAEELGDLLLQVVFHAQVAQEAGEFQFQDVLKGI 311 Query: 196 -ENLRKRH 202 + + +RH Sbjct: 312 IDKMIRRH 319 >UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii KC4 RepID=C9RA19_AMMDK Length = 495 Score = 42.9 bits (100), Expect = 0.007, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 25/62 (40%), Gaps = 6/62 (9%) Query: 146 IAQKVGEEGVETALAA--TVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR 199 + + + EE E A D L E DL+ +H + + +L V+ ++ Sbjct: 262 LKKYLLEETYEVLEAIDRVEEDPHNLCEELGDLLLQIVFHCQIAAEAGRFNLDDVVRSIT 321 Query: 200 KR 201 ++ Sbjct: 322 RK 323 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.315 0.154 0.494 Lambda K H 0.267 0.0475 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,478,809,273 Number of Sequences: 3077464 Number of extensions: 69290161 Number of successful extensions: 173018 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 717 Number of HSP's successfully gapped in prelim test: 121 Number of HSP's that attempted gapping in prelim test: 171668 Number of HSP's gapped (non-prelim): 978 length of query: 203 length of database: 1,040,396,356 effective HSP length: 122 effective length of query: 81 effective length of database: 664,945,748 effective search space: 53860605588 effective search space used: 53860605588 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 90 (39.1 bits)