BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (203 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac...   270   2e-71
UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac...   228   1e-58
UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact...   226   2e-58
UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos...   212   7e-54
UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba...   211   2e-53
UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ...   202   6e-51
UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   199   5e-50
UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   197   2e-49
UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p...   197   2e-49
UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   195   8e-49
UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero...   190   2e-47
UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   188   9e-47
UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ...   187   2e-46
UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman...   181   9e-45
UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His...   176   3e-43
UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos...   175   7e-43
UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri...   175   1e-42
UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana...   172   7e-42
UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul...   169   4e-41
UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   168   9e-41
UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero...   167   2e-40
UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm...   163   3e-39
UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm...   161   2e-38
UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri...   160   3e-38
UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His...   160   3e-38
UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr...   159   7e-38
UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific...   153   4e-36
UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob...   152   6e-36
UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy...   152   6e-36
UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   151   1e-35
UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   149   4e-35
UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte...   149   8e-35
UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   148   1e-34
UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI...   147   2e-34
UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5     147   2e-34
UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   147   3e-34
UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra...   146   4e-34
UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell...   145   1e-33
UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   142   5e-33
UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI...   141   1e-32
UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   138   9e-32
UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy...   137   2e-31
UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon...   136   4e-31
UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper...   136   4e-31
UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   135   9e-31
UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep...   133   3e-30
UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote...   133   4e-30
UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI...   133   4e-30
UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   133   5e-30
UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ...   132   5e-30
UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   131   1e-29
UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   131   2e-29
UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi...   130   3e-29
UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   130   4e-29
UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   125   1e-27
UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell...   120   3e-26
UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A...   119   4e-26
UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   113   3e-24
UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI...   112   6e-24
UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero...   112   7e-24
UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m...   112   1e-23
UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul...   108   1e-22
UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar...   107   3e-22
UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   105   7e-22
UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr...   105   7e-22
UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro...   105   1e-21
UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap...   104   2e-21
UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   104   2e-21
UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax...   103   2e-21
UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote...   103   3e-21
UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel...   102   5e-21
UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin...   102   7e-21
UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap...   102   1e-20
UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon...   102   1e-20
UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin...   101   1e-20
UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p...   101   2e-20
UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote...   101   2e-20
UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin...   100   2e-20
UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote...   100   3e-20
UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   100   3e-20
UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte...   100   3e-20
UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   100   4e-20
UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon...   100   5e-20
UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...    99   6e-20
UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu...    99   1e-19
UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...    99   1e-19
UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte...    98   1e-19
UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact...    98   2e-19
UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo...    98   2e-19
UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein...    98   2e-19
UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob...    97   3e-19
UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero...    97   3e-19
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...    97   3e-19
UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...    96   7e-19
UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...    96   8e-19
UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...    95   1e-18
UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm...    94   2e-18
UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros...    94   2e-18
UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu...    94   3e-18
UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo...    94   4e-18
UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte...    93   4e-18
UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom...    93   5e-18
UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid...    93   6e-18
UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact...    93   6e-18
UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob...    92   9e-18
UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin...    92   9e-18
UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte...    92   1e-17
UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote...    91   2e-17
UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte...    91   2e-17
UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell...    91   2e-17
UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...    91   2e-17
UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax...    91   2e-17
UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein...    90   4e-17
UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch...    90   5e-17
UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom...    90   5e-17
UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...    89   8e-17
UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...    88   2e-16
UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi...    88   2e-16
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...    88   2e-16
UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo...    87   3e-16
UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo...    87   3e-16
UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...    87   4e-16
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...    86   5e-16
UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote...    86   6e-16
UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu...    86   7e-16
UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob...    86   8e-16
UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl...    86   8e-16
UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz...    86   1e-15
UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter...    84   2e-15
UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=...    84   3e-15
UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo...    84   3e-15
UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...    84   4e-15
UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...    83   5e-15
UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T...    83   6e-15
UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob...    82   1e-14
UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ...    82   1e-14
UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph...    81   2e-14
UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu...    81   2e-14
UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing...    80   5e-14
UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    80   6e-14
UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo...    79   1e-13
UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros...    78   2e-13
UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan...    77   3e-13
UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph...    77   3e-13
UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax...    75   1e-12
UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico...    74   2e-12
UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha...    74   4e-12
UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor...    73   5e-12
UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo...    73   5e-12
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...    73   8e-12
UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri...    72   1e-11
UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin...    71   3e-11
UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...    71   3e-11
UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo...    70   4e-11
UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph...    68   2e-10
UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap...    67   4e-10
UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi...    66   7e-10
UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph...    65   1e-09
UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    65   2e-09
UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu...    64   2e-09
UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther...    64   2e-09
UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell...    64   2e-09
UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov...    64   3e-09
UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk...    64   3e-09
UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha...    64   4e-09
UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact...    62   2e-08
UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote...    62   2e-08
UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu...    61   2e-08
UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob...    61   2e-08
UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos...    61   2e-08
UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...    61   2e-08
UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl...    61   2e-08
UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta...    61   3e-08
UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=...    60   4e-08
UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos...    60   4e-08
UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot...    60   6e-08
UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu...    59   8e-08
UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury...    59   9e-08
UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta...    58   2e-07
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...    58   2e-07
UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm...    58   2e-07
UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost...    58   2e-07
UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo...    57   3e-07
UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto...    56   7e-07
UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C...    56   9e-07
UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...    55   2e-06
UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...    54   3e-06
UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    54   5e-06
UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo...    53   7e-06
UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot...    52   1e-05
UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo...    52   1e-05
UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul...    51   2e-05
UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins...    51   2e-05
UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto...    51   2e-05
UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob...    51   2e-05
UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha...    50   3e-05
UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh...    50   4e-05
UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br...    50   5e-05
UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost...    50   6e-05
UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    50   6e-05
UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot...    47   3e-04
UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph...    47   4e-04
UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re...    46   8e-04
UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom...    45   0.001
UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p...    45   0.002
UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha...    44   0.003
UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba...    43   0.007
UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc...    42   0.011

>UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria
           RepID=HIS2_VIBVY
          Length = 211

 Score =  270 bits (690), Expect = 2e-71,   Method: Compositional matrix adjust.
 Identities = 131/197 (66%), Positives = 161/197 (81%), Gaps = 3/197 (1%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           ++WEK DGL+P IVQ   S +VLM+GYMN +AL KT E+G+VTFFSRTK+RLWTKGETSG
Sbjct: 15  INWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERLWTKGETSG 74

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAH--QWLFLYQLEQLLAERK 126
           N L +V+++ DCDNDTLLV  NPIGPTCH GT++C+ GD     Q ++L+QLEQLLA RK
Sbjct: 75  NVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQLEQLLAARK 134

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           SADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT  D+ EL  E++DL+YHLLVLLQD
Sbjct: 135 SADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIYHLLVLLQD 194

Query: 187 QGLDLTTVIENLRKRHQ 203
           QGL +  VI  L++RH+
Sbjct: 195 QGLSMNDVINKLKERHK 211


>UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria
           RepID=HIS2_BLOFL
          Length = 213

 Score =  228 bits (581), Expect = 1e-58,   Method: Compositional matrix adjust.
 Identities = 110/206 (53%), Positives = 149/206 (72%), Gaps = 5/206 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT ++ + L+W K  GL+P I+QH++SGEVLMLGYMN E++  T ++G VTFFSR+K R
Sbjct: 1   MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGE+SGN L +++  PDCD D+LL+L  P G TCHK T+SCF      + FL+QLE 
Sbjct: 61  LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120

Query: 121 LLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +K+      + ++SYT+ LY SG +RIAQKVGEEG+ETALAA   +   L +EASD
Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           L+YHLLVLLQ + L+   VI+ LR R
Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVR 206


>UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria
           RepID=HIS2_XANCP
          Length = 206

 Score =  226 bits (577), Expect = 2e-58,   Method: Compositional matrix adjust.
 Identities = 116/194 (59%), Positives = 136/194 (70%), Gaps = 2/194 (1%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LDW K DGL+PVIVQ A +  VLMLGYMN EAL  T   G+VTFFSR+KQRLWTKGE+SG
Sbjct: 15  LDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGESSG 74

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           N L VV+I  DCD DTLLV A P GPTCH G +SCF     Q  FL  L+ L+AER+   
Sbjct: 75  NVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTAPSQ--FLGSLDALIAEREHER 132

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           P  SYT KL+  G +RIAQKVGEEGVETALA  V    EL  E++DL+YHL+VLL+ +GL
Sbjct: 133 PHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRARGL 192

Query: 190 DLTTVIENLRKRHQ 203
            L   +  L  RH+
Sbjct: 193 GLGDAVALLESRHK 206


>UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc
           (Cinara cedri) RepID=Q058A1_BUCCC
          Length = 205

 Score =  212 bits (539), Expect = 7e-54,   Method: Compositional matrix adjust.
 Identities = 95/203 (46%), Positives = 135/203 (66%), Gaps = 3/203 (1%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           ML +Q  + L+W K +GL+P I QH +SGE+LM GYMN +A DK + +   T +SR K+R
Sbjct: 1   MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ--WLFLYQL 118
           +W KGETS NFL V +I+ DCD D +LV  NP G TCH    SCF +++HQ  + FLY+L
Sbjct: 61  IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCF-ESSHQLPYTFLYKL 119

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E  +  +K     +SY + L++SG  RIAQK+GEE VE  +A   ++   + NE SDL++
Sbjct: 120 ENRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIF 179

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           HL +LLQ   ++L  +I+NL+KR
Sbjct: 180 HLFILLQSMNINLYKIIKNLQKR 202


>UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae
           RepID=C5SM65_9CAUL
          Length = 215

 Score =  211 bits (536), Expect = 2e-53,   Method: Compositional matrix adjust.
 Identities = 109/194 (56%), Positives = 135/194 (69%), Gaps = 1/194 (0%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LD+ K DGL+P IVQ A + +VLMLGYM+  AL +TL   +VTFFSR+K   W KGETSG
Sbjct: 19  LDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGRWRKGETSG 78

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-DTAHQWLFLYQLEQLLAERKSA 128
           +FLN+VS+  DCD D LLVLA P+GPTCH  T+SCFG DTA    F+  L  ++ +R  A
Sbjct: 79  DFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAAVVKDRAKA 138

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
            P  SYTA+L   G  +IAQKVGEEG+ETALA    D  EL NEA+DL+YHL VLL  + 
Sbjct: 139 PPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHLSVLLMARD 198

Query: 189 LDLTTVIENLRKRH 202
             L  V++ LR+RH
Sbjct: 199 TTLEAVLDILRERH 212


>UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT
          Length = 215

 Score =  202 bits (514), Expect = 6e-51,   Method: Compositional matrix adjust.
 Identities = 98/197 (49%), Positives = 135/197 (68%), Gaps = 2/197 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   +  VLMLGYMN EA  KT+E+ KVTF+SR++  LWTKGETS
Sbjct: 2   QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126
           GN+L++VSI  DCDNDTLLV  +P GPTCH GT +C+G+T   +  LFL +L+  +  R 
Sbjct: 62  GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P+ SYT  L+  G ++IAQKVGEE VET + A   +   L  EASD++YHL+VLL  
Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181

Query: 187 QGLDLTTVIENLRKRHQ 203
           +GL +  +   L +RH 
Sbjct: 182 KGLHIEDLARELARRHN 198


>UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=A9B1U1_HERA2
          Length = 212

 Score =  199 bits (506), Expect = 5e-50,   Method: Compositional matrix adjust.
 Identities = 103/197 (52%), Positives = 127/197 (64%), Gaps = 9/197 (4%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P +VQHA SGEVLM+GYMN EAL KT  SG VTF+SR++Q+LWTKGETSGN L  
Sbjct: 8   SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETSGNVLKF 67

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQLEQLLAER 125
           ++   DCDND LL+LA P GPTCH G+ SCF  T         A    F+ QL + L ER
Sbjct: 68  IAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLFEFLRER 127

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
           +   P  SYT  L   G  +I +K+GEE  E  +AA   +  EL NEASDL+YHL VLL 
Sbjct: 128 EQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYHLFVLLL 187

Query: 186 DQGLDLTTVIENLRKRH 202
           +QG+    V   LR+RH
Sbjct: 188 NQGVSPEDVWFTLRERH 204


>UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Legionella
           RepID=C6N0X1_9GAMM
          Length = 207

 Score =  197 bits (501), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 95/193 (49%), Positives = 131/193 (67%), Gaps = 1/193 (0%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LDW+K +GL+P I+Q+A +G VLMLGYMN EAL  T+ +G++T +SR+++RLW KGETSG
Sbjct: 9   LDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGETSG 68

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-FLYQLEQLLAERKSA 128
           N + V  I+ DCD+D+LL++  P GP CH G +SC+    H  + F+  L +++ ER   
Sbjct: 69  NTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINERAET 128

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
             E SYTA+L ASG  R AQKVGEE VET +AA      E  NE +DL++HLLVLL+   
Sbjct: 129 QAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLKASE 188

Query: 189 LDLTTVIENLRKR 201
           L    V++ L+ R
Sbjct: 189 LSFYDVLQCLQDR 201


>UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1
           Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL
          Length = 207

 Score =  197 bits (501), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 1/195 (0%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +D+EK +GL+PV+VQ A + +VL L YM+  ALD+T++SG+ TFFSR++   W KGETSG
Sbjct: 7   IDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGETSG 66

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-LYQLEQLLAERKSA 128
           + L+VV I  DCD+D L++  NP+G  CH   +SCFG      L  + +LEQ +AER +A
Sbjct: 67  DRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERAAA 126

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP  S+TAKL   G KRIAQKVGEEGVETALA       EL +EA+DL+YHLLVLL  + 
Sbjct: 127 DPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHARN 186

Query: 189 LDLTTVIENLRKRHQ 203
           +    V++ L  R +
Sbjct: 187 MVFQDVLDVLASRAE 201


>UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=2 Tax=Francisella philomiragia
           RepID=B0TY40_FRAP2
          Length = 207

 Score =  195 bits (495), Expect = 8e-49,   Method: Compositional matrix adjust.
 Identities = 102/194 (52%), Positives = 136/194 (70%), Gaps = 3/194 (1%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           W+K D L+P I+Q A+   VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTKGE SGNF
Sbjct: 11  WQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTKGEESGNF 70

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--GDTAHQWLFLYQLEQLLAERKSAD 129
           L +  IA DCDND++L+ A P GPTCH G+ SCF   +       + +LE+L+AE+K   
Sbjct: 71  LELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLIAEKKDYL 130

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD-RFELTNEASDLMYHLLVLLQDQG 188
           PE SY   L+  G  RIAQKVGEEGVE  +AA   D   EL +E +DL++HLLVLL+++G
Sbjct: 131 PENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLLVLLREKG 190

Query: 189 LDLTTVIENLRKRH 202
           + L  + + L  R+
Sbjct: 191 ISLEQICQKLVSRN 204


>UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes
           RepID=C6W0Y7_DYAFD
          Length = 213

 Score =  190 bits (483), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 106/206 (51%), Positives = 136/206 (66%), Gaps = 12/206 (5%)

Query: 10  LDWEKT-DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +D+ K+ DGL+P ++Q   +G+VLMLGYMN EALD T + G VTFFSR+KQRLWTKGETS
Sbjct: 8   IDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWTKGETS 67

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFL-YQ 117
           GNFL V  IA DCD DTLL+ A P GP CH G  +CFG+           A +  FL Y 
Sbjct: 68  GNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAAFLNYL 127

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
            ++++ ERK    + SYT+ L+  G  +IAQKVGEE VE  + +   D     NE SDL+
Sbjct: 128 QKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNEVSDLL 187

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +HLLVLL+ + +DL  VI+ LR RHQ
Sbjct: 188 FHLLVLLEQKNIDLDEVIDVLRSRHQ 213


>UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=4 Tax=Flavobacteriales
           RepID=A4CLC1_9FLAO
          Length = 206

 Score =  188 bits (478), Expect = 9e-47,   Method: Compositional matrix adjust.
 Identities = 98/203 (48%), Positives = 133/203 (65%), Gaps = 8/203 (3%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
           + +D+EKT GL+P I+Q + +  VLMLGYM+ EAL+ T  SGKVTF+SR+K+RLWTKGE+
Sbjct: 2   KSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGES 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW--LFLYQLEQLLAER 125
           SGNFL  V +  DCD D LL+ A P GP CH G+ +C+ D A+     FL +LE ++A R
Sbjct: 62  SGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCW-DEANPGDEDFLPELEAIIASR 120

Query: 126 KS-AD----PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           K  AD       SY A L   GT ++AQKVGEE VET + A   D     NE++DL++H 
Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           L+LLQ +G  +  +   L +RH+
Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203


>UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera
           aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR
          Length = 204

 Score =  187 bits (476), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 95/203 (46%), Positives = 130/203 (64%), Gaps = 1/203 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT  Q  +L+W+K + L+P+IVQ   S E+LM GY N ++L  TL+  K+TFFSRTK R
Sbjct: 1   MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-FLYQLE 119
           LWTKGETS N+L V+ I PDCD D+LL L   IG TCH    SCF    +  + F+ +LE
Sbjct: 61  LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           ++L   K  +  TSYT+ LY  G  +I+QKVGEE VE  +AA   D+  +  E +DL+YH
Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVL     +    +I+ L+KR+
Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203


>UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B858_THEAS
          Length = 205

 Score =  181 bits (460), Expect = 9e-45,   Method: Compositional matrix adjust.
 Identities = 95/199 (47%), Positives = 120/199 (60%), Gaps = 6/199 (3%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           ++W   D L+PV+VQ A SG VLML Y N EALD TL+ G+  FFSR++ RLW KGETSG
Sbjct: 5   IEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGETSG 63

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQLLAE 124
           N + V+ +  DCD D++L L    GP CH G  SCF     G      LFL++L +++ +
Sbjct: 64  NTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIVDQ 123

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R S   + SYT  L+  G  RIAQKVGEEGVE ALA    DR     EA+DL+YHL V L
Sbjct: 124 RISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTVAL 183

Query: 185 QDQGLDLTTVIENLRKRHQ 203
           +     L    + L  RHQ
Sbjct: 184 RRVDATLLDAEQVLMARHQ 202


>UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT
          Length = 233

 Score =  176 bits (447), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 88/190 (46%), Positives = 122/190 (64%), Gaps = 5/190 (2%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQH  +G+VLMLGYM  EA + T  +GKVTFFSR+++++W KGETSGN L+V+ I
Sbjct: 26  LIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSRKKIWVKGETSGNGLDVMDI 85

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLAERKSADPET 132
             DCD DT+LVLA P+GPTCH G+ SCF  +  Q     +    +L+  + ERK+ DP+ 
Sbjct: 86  RWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFEVWSELQSTVRERKTGDPDI 145

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA L  S    + +K+ EE  E +LA  V  R    +E +DL +H+ V L+  G+   
Sbjct: 146 SYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEWADLFFHIAVALEKTGVSWG 205

Query: 193 TVIENLRKRH 202
            V+E LRKR 
Sbjct: 206 EVMEILRKRQ 215


>UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP
           cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NG19_KYTSD
          Length = 244

 Score =  175 bits (444), Expect = 7e-43,   Method: Compositional matrix adjust.
 Identities = 100/229 (43%), Positives = 130/229 (56%), Gaps = 35/229 (15%)

Query: 9   ELDWEK-TD---GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           E+D+ + TD   GL+  +VQ A +  VLM+G+M+  AL+ T  +G+VTF+SR++   W K
Sbjct: 15  EVDFSRVTDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVK 74

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF------------------- 105
           GETSGN L+VVS+  DCD D +LV+A P GPTCH G +SCF                   
Sbjct: 75  GETSGNTLDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAA 134

Query: 106 ------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEE 153
                       G T      +  L + +AER    P  SYT  L+  GT+RIAQKVGEE
Sbjct: 135 SGAGGDAPASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEE 194

Query: 154 GVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           GVETALA       EL  E++DL+YHL+VLL D+GL L  V   LR R 
Sbjct: 195 GVETALAGVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243


>UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria
           RepID=C6J1M1_9BACL
          Length = 231

 Score =  175 bits (443), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 91/199 (45%), Positives = 124/199 (62%), Gaps = 12/199 (6%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ A S EVLML YMN E+L K++E+G+  F+SR++  LW KG TSGN   + +
Sbjct: 28  GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELWNKGATSGNTQQITA 87

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA------------HQWLFLYQLEQLLAE 124
           +  DCD DTLLV     GP CH G  +CF  TA             ++  L +LEQL+AE
Sbjct: 88  LKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADERFKVLAELEQLIAE 147

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R +  PE +YT  L+  G  +I +KVGEE  E+ +AA   D  EL  E SDL+YHLLVLL
Sbjct: 148 RYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELRYEVSDLIYHLLVLL 207

Query: 185 QDQGLDLTTVIENLRKRHQ 203
           +++ L L  +++ L +RH+
Sbjct: 208 RERNLPLDEIMQELERRHE 226


>UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius
           thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ
          Length = 211

 Score =  172 bits (436), Expect = 7e-42,   Method: Compositional matrix adjust.
 Identities = 90/201 (44%), Positives = 121/201 (60%), Gaps = 14/201 (6%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V 
Sbjct: 8   DGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVT 67

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF------GDTAHQWLF--------LYQLEQL 121
           S+  DCD DTLL L  P GP CH G +SCF       D +  + F        L  L QL
Sbjct: 68  SLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQL 127

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + +R    P+ SY  KL   G  ++ +KVGEE  E   A    D+ E+ +E++DL++H L
Sbjct: 128 IEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHTL 187

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
           + L+   +DL+ V++ L  RH
Sbjct: 188 LALKYFQVDLSEVLQELHNRH 208


>UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms
           RepID=C9RV77_GEOSY
          Length = 216

 Score =  169 bits (429), Expect = 4e-41,   Method: Compositional matrix adjust.
 Identities = 97/195 (49%), Positives = 125/195 (64%), Gaps = 9/195 (4%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ A S EVL L YMN E+L+KTLE+G+  F+SR++Q LW KG TSGN   VV 
Sbjct: 11  GLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGATSGNVQRVVD 70

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQLEQLLAERKS 127
           I  DCD D LLVL  P GP CH G+ SCF  +         A ++  L +LEQ++A+R +
Sbjct: 71  IRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNELEQIIAKRDA 130

Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
             PE SYT  L+  G  +I +KVGEE  E  +AA   +  EL  EA+DL+YHLLVLL++Q
Sbjct: 131 ERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLYHLLVLLREQ 190

Query: 188 GLDLTTVIENLRKRH 202
            L L  V+  L +RH
Sbjct: 191 KLPLDAVLATLAERH 205


>UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TLB5_9BACT
          Length = 188

 Score =  168 bits (426), Expect = 9e-41,   Method: Compositional matrix adjust.
 Identities = 88/188 (46%), Positives = 117/188 (62%), Gaps = 5/188 (2%)

Query: 21  VIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPD 80
           ++VQ A SGEVLML Y N E++  TLE G++ F+SR+++ +W KG TSGN L + S+  D
Sbjct: 1   MVVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQID 60

Query: 81  CDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQLLAERKSADPETSYT 135
           CD D +L   +P+GP CH G  SCF     G+     +FL +L   L +R    PE SYT
Sbjct: 61  CDCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYT 120

Query: 136 AKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI 195
           A+L A    R+AQK+GEEGVETALA    DR +   EA+DL+YHLLV L    L    + 
Sbjct: 121 ARLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIW 180

Query: 196 ENLRKRHQ 203
             L+KRH+
Sbjct: 181 RELKKRHK 188


>UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C4Y5_SPHTD
          Length = 228

 Score =  167 bits (424), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 88/195 (45%), Positives = 121/195 (62%), Gaps = 9/195 (4%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGETSGN   VV 
Sbjct: 23  GLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGETSGNVHEVVE 82

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF-------GDTA--HQWLFLYQLEQLLAERKS 127
           I PDCD D LLV   P GPTCH GT +CF       G+ A       + ++ +++AER++
Sbjct: 83  IRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDEVARVVAERRA 142

Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
              E SYT  L  +G  +I +K+GEE  E  +AA   D   L NEA+DL+YHLLVLL+  
Sbjct: 143 HPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLIYHLLVLLEAS 202

Query: 188 GLDLTTVIENLRKRH 202
            +    V   LR R 
Sbjct: 203 DVPTERVWAVLRTRR 217


>UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes
           RepID=HIS2_OCEIH
          Length = 215

 Score =  163 bits (413), Expect = 3e-39,   Method: Compositional matrix adjust.
 Identities = 82/191 (42%), Positives = 116/191 (60%), Gaps = 5/191 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   SG+VL L YMN +++ KT+E+ +  F+SR +Q LW KG TSGN   V  
Sbjct: 16  GLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQELWNKGATSGNKQTVKQ 75

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLAERKSADPE 131
           I+ DCD D +LVL +  GP CH G  SCF +  ++        + Q+   + ER     E
Sbjct: 76  ISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQIIPQVSAKIKERHEHPVE 135

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            +YT+ L+  G  +I +K+GEE  E  +AA   D+ ELT+E SDL+YH LVL++ QG+ L
Sbjct: 136 GAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSDLLYHSLVLMEQQGVTL 195

Query: 192 TTVIENLRKRH 202
             + + L KRH
Sbjct: 196 EDIKKELYKRH 206


>UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga
           RepID=HIS2_THEMA
          Length = 197

 Score =  161 bits (407), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+VQ   +GEVLML Y N EAL+ T ++G   FFSR +Q++W KGETSGN + VV I
Sbjct: 4   LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63

Query: 78  APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQW------LFLYQLEQLLAERKSAD 129
             DCD+D  L + +       CH G  SCF    H++       F  +L +L+ +RK   
Sbjct: 64  RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT KL+  G  +IA+K GEE VE       +DR  L  E +D+MYHL VL+ D G+
Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183

Query: 190 DLTTVIENLRKRHQ 203
            +  V+  L KR +
Sbjct: 184 TVQDVMRELEKRRK 197


>UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria
           RepID=C6PCK8_CLOTS
          Length = 228

 Score =  160 bits (404), Expect = 3e-38,   Method: Compositional matrix adjust.
 Identities = 79/194 (40%), Positives = 116/194 (59%), Gaps = 8/194 (4%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   + EVLM+ YMN E+L+K+LE+ +  FFSR++Q LW KGETSGN  ++ +
Sbjct: 18  GLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKGETSGNVQHIKA 77

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAERKSA 128
           I  DCD DTLLV   P GP CH G +SCF         +   +   L  L + +  RK  
Sbjct: 78  IKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSNLYRRIESRKEN 137

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
               SYT  L+  G  +I +K+GEE  E  +A+    + E+  E +D +YHL+VL+ ++G
Sbjct: 138 PVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYIYHLMVLMVEKG 197

Query: 189 LDLTTVIENLRKRH 202
           ++L  V + + KR+
Sbjct: 198 INLNDVYKEISKRY 211


>UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT
          Length = 230

 Score =  160 bits (404), Expect = 3e-38,   Method: Compositional matrix adjust.
 Identities = 87/192 (45%), Positives = 115/192 (59%), Gaps = 8/192 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+ Q    G+VLM+GYMN EA  +T+E G+VTFFSR+++RLWTKGE+SG+FL +VS+
Sbjct: 16  LRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWTKGESSGHFLRLVSL 75

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFG------DTAHQWLF--LYQLEQLLAERKSAD 129
             DCD DTLL L  P GPTCH GT SCF        T  +  F  L  L   +A R+  D
Sbjct: 76  RYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETLGDLAGTIALRRDGD 135

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PETSY A+L +     + +K+ EE  ET  A    D     +E +DL++HLLV ++    
Sbjct: 136 PETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMADLLFHLLVAMERTRT 195

Query: 190 DLTTVIENLRKR 201
               V+  L KR
Sbjct: 196 PWEEVVGVLEKR 207


>UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI0001910D6A
          Length = 157

 Score =  159 bits (401), Expect = 7e-38,   Method: Compositional matrix adjust.
 Identities = 74/81 (91%), Positives = 77/81 (95%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR
Sbjct: 77  MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136

Query: 61  LWTKGETSGNFLNVVSIAPDC 81
           LWTKGETSG+ LNVVSIAPDC
Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157


>UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae
           RepID=B4U8T9_HYDS0
          Length = 207

 Score =  153 bits (386), Expect = 4e-36,   Method: Compositional matrix adjust.
 Identities = 81/195 (41%), Positives = 115/195 (58%), Gaps = 8/195 (4%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PVI Q A SGE+ ML Y N EA+ KT+E+G   +FSR++  +W KGETSG    V+ 
Sbjct: 12  GLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGETSGELQEVLE 71

Query: 77  IAPDCDNDTLL-VLANPIGPTCHKGTSSCF---GDTAHQWLFLYQ----LEQLLAERKSA 128
           I  DCDNDTL+ ++       CH G  +CF    D     L  ++    LE+L+ +R S 
Sbjct: 72  IRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFLERLIKDRISN 131

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
             E+SYT+KL   G  RI QKVGEE +E+ +A    D+ E+  E +DL+YH+LV ++   
Sbjct: 132 PVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIYHILVGIKYSN 191

Query: 189 LDLTTVIENLRKRHQ 203
           +    V   L +RH+
Sbjct: 192 MSFEDVEFELIRRHK 206


>UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria
           RepID=B5EQF3_ACIF5
          Length = 230

 Score =  152 bits (385), Expect = 6e-36,   Method: Compositional matrix adjust.
 Identities = 84/198 (42%), Positives = 115/198 (58%), Gaps = 11/198 (5%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q A SG VLML +MN +AL  TL  G  T++SR++Q LW KGETSG+  ++
Sbjct: 19  ADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRKGETSGHIQHL 78

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--GDTAHQ-WL--------FLYQLEQLLA 123
           V +  DCD DTLL+     GP CH G  +CF  G    Q W          L  L+  L 
Sbjct: 79  VDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGSILDSLQVTLH 138

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R++ADP  SY A+L   G  RI +KVGEE  E  +A   H+   +  EA+DL++HL+V 
Sbjct: 139 NRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEAADLVFHLMVA 198

Query: 184 LQDQGLDLTTVIENLRKR 201
           L+++ L +  V+  L +R
Sbjct: 199 LEERDLHIDDVLGELARR 216


>UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae
           RepID=D0LRT4_HALO1
          Length = 241

 Score =  152 bits (385), Expect = 6e-36,   Method: Compositional matrix adjust.
 Identities = 85/201 (42%), Positives = 117/201 (58%), Gaps = 16/201 (7%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L V  
Sbjct: 24  GLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLAVRE 83

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF---------------GDTAHQWLFLYQLEQL 121
           +  DCD D ++V+A P GPTCH GT SCF               G +      L +LE +
Sbjct: 84  LRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKLEGV 143

Query: 122 LAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           +A R+ SAD E SYT  L   G  +I  K+ EE  E A      +R E+ +E +DL++H+
Sbjct: 144 IAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLLFHV 203

Query: 181 LVLLQDQGLDLTTVIENLRKR 201
           +V L  + + L  V   L +R
Sbjct: 204 MVGLAARDIALDEVWGELSRR 224


>UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI
          Length = 244

 Score =  151 bits (382), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 86/211 (40%), Positives = 112/211 (53%), Gaps = 26/211 (12%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q ++S EVLML YMN EAL+ TL++G   +FSR+KQR+W KGE SGN   V  
Sbjct: 12  GLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSGNIQEVCE 71

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF----------------------GDTAHQWLF 114
           I  DCD+D++L+  N  G  CH G  SCF                       D+    L 
Sbjct: 72  IKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKDSLTHSLN 131

Query: 115 LYQ----LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
            Y     L   L ERK+AD  TSYTA L+A GT  IA+K+ EE  E   A    D  E+ 
Sbjct: 132 TYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKDRDSKEII 191

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +D+ YH+LV L  + +    + + L KR
Sbjct: 192 YECADVFYHILVGLASENIHPDRIYQELIKR 222


>UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_PYRFU
          Length = 209

 Score =  149 bits (377), Expect = 4e-35,   Method: Compositional matrix adjust.
 Identities = 91/213 (42%), Positives = 126/213 (59%), Gaps = 14/213 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  E+   +++WEK +G++PVIVQ    GEVL L YMN EAL KTLE+G   ++SR+K R
Sbjct: 1   MEIEKLLEQVNWEKNNGIVPVIVQDE-KGEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF----GDTA------H 110
           +  KGE SGN   V  I  DCDND LL++ +P GP CH G  SCF    G+        +
Sbjct: 60  IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE+++  RK    E SYT+KL+  G ++I +K GEE +E  +A     R  + 
Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVA---EKRERII 176

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E +DL+YHLLVLL    + L  V+  LR+R +
Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209


>UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria
           RepID=HIS2_AQUAE
          Length = 205

 Score =  149 bits (375), Expect = 8e-35,   Method: Compositional matrix adjust.
 Identities = 77/197 (39%), Positives = 117/197 (59%), Gaps = 9/197 (4%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+PVI Q   +GEV ML Y N EA+ KTLE+G   ++SR+++++W KGETSG    V+
Sbjct: 9   EGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETSGELQKVI 68

Query: 76  SIAPDCDNDTLL-VLANPIGPTCHKGTSSCF-----GDTAHQWL---FLYQLEQLLAERK 126
            +  DCD D L+ V+       CH G  +CF     G+   + L    L +L+ ++ E+ 
Sbjct: 69  EVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQDVIREKI 128

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
               E SYTAKL + G +R+ QK GEE VET +A    ++ E+  E++D++Y  LV L  
Sbjct: 129 ERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYTFLVSLSV 188

Query: 187 QGLDLTTVIENLRKRHQ 203
            G+D+  V+E L +R +
Sbjct: 189 SGIDIKEVMEELIRRFK 205


>UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=10 Tax=Bacteria
           RepID=C0QVS5_BRAHW
          Length = 220

 Score =  148 bits (373), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 76/190 (40%), Positives = 110/190 (57%), Gaps = 5/190 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IV    + EVL L YMN E+L+ +++  K  F+SR++Q LW KGETSGN+ ++ S
Sbjct: 18  GLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQELWRKGETSGNYQHIQS 77

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-----HQWLFLYQLEQLLAERKSADPE 131
           I  DCDND L++     GP CH G+ SCF +       ++   + +L +L+  RK    E
Sbjct: 78  IKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSIDKLYKLIEGRKINQTE 137

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            SYT  L+ SG  +I +KVGEE  E  + A      E   E SDL+YH LVL+ ++G+ +
Sbjct: 138 GSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDLLYHSLVLMVEKGITI 197

Query: 192 TTVIENLRKR 201
             +   L  R
Sbjct: 198 NDIKNELASR 207


>UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3
           Tax=Chloroflexi RepID=B9KXC5_THERP
          Length = 218

 Score =  147 bits (372), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 88/200 (44%), Positives = 124/200 (62%), Gaps = 13/200 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KGETSG+ L +
Sbjct: 17  ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKGETSGHVLEL 76

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH---------QWLFLYQLEQLLAER 125
           V +  DCD D LL   +P GPTCH G  SCF DT               L +L  ++A R
Sbjct: 77  VELRTDCDGDALLARVHPHGPTCHTGRPSCF-DTEPLVGTSQDPVNATILDELASIIAAR 135

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
                  SYT+ L  +G  RIA+K+GEE  E  +AA   +   +  EA+DL+YHLLVLLQ
Sbjct: 136 AVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLLYHLLVLLQ 195

Query: 186 DQGL---DLTTVIENLRKRH 202
             G+   ++  V++  R RH
Sbjct: 196 ASGVPAGEVWRVLQARRGRH 215


>UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5
          Length = 229

 Score =  147 bits (372), Expect = 2e-34,   Method: Compositional matrix adjust.
 Identities = 85/199 (42%), Positives = 113/199 (56%), Gaps = 15/199 (7%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQ  ++G+V ML YM  E+L +TLE+G+ TFFSR++  LW KG TSGN L V S+
Sbjct: 10  LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF-------GDTAHQWLFLYQ--------LEQLL 122
             DCD D LL+LA P GPTCH G++SCF       GD   +     Q        LE+ L
Sbjct: 70  HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
             RK++    SYT KL   G   I  K+ EE  E A A        + +EA+D++YHLLV
Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L  +G+ L  V+  L  R
Sbjct: 190 GLASRGVPLRAVLSALASR 208


>UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=1 Tax=Candidatus Poribacteria
           sp. WGA-A3 RepID=D2MIV8_9BACT
          Length = 234

 Score =  147 bits (370), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 80/199 (40%), Positives = 116/199 (58%), Gaps = 15/199 (7%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P +VQ    G +LML YMN EALD+TL++G V F+SR++++LW KGETSG++L    
Sbjct: 22  GLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSGHYLLCKR 81

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------GDTAHQWLFLYQLEQLL 122
           +  DCD D LLV A P GPTCH    +CF              G+ A+  +F  +L +++
Sbjct: 82  VFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIF-DRLYEMV 140

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +RK+   E SY + L   G  RI +KV EE  E  LA     R E+ +E +DL++H +V
Sbjct: 141 LQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADLIFHSIV 200

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L    + +T + + L KR
Sbjct: 201 ALGHCEIPMTAIQQELGKR 219


>UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1
           Tax=Raoultella terrigena RepID=Q6U8A9_KLETE
          Length = 88

 Score =  146 bits (369), Expect = 4e-34,   Method: Compositional matrix adjust.
 Identities = 71/83 (85%), Positives = 75/83 (90%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL
Sbjct: 6   LLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHL 65

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +VLLQDQ L L  +I NL+ RHQ
Sbjct: 66  MVLLQDQELSLQDIIANLKSRHQ 88


>UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms
           RepID=HIS2_THEP3
          Length = 216

 Score =  145 bits (365), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 78/201 (38%), Positives = 111/201 (55%), Gaps = 21/201 (10%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PVI Q   + EVLM+ Y+    L K+LE+GKV +FSR++ +LW KGETSG+F  + S
Sbjct: 14  GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWLKGETSGHFQLIKS 73

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GD----------------TAHQWLFL 115
           I+ DCD DTLL+    +   CH G  SCF     G+                 A     L
Sbjct: 74  ISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFDEQKVYEAENAKIL 133

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            ++  ++ +R     E SYT  L+  G  +I +KVGEE  E  + A   D+ E+  E SD
Sbjct: 134 QEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAKNRDKGEIVYEISD 193

Query: 176 LMYHLLVLLQDQGLDLTTVIE 196
           L+YHLLVL+ ++G+ L  + E
Sbjct: 194 LIYHLLVLMVERGIKLEDIYE 214


>UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC
          Length = 251

 Score =  142 bits (359), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 82/237 (34%), Positives = 122/237 (51%), Gaps = 40/237 (16%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           + + ++DW+K  GL+PV++Q   +GEVLM+ YMN EAL+ T  +G   +FSR+K R+W K
Sbjct: 3   ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------GDTAHQ----- 111
           GE+SGN   V S   DCDNDTLL+     G  CH G  SCF        G+  H+     
Sbjct: 62  GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121

Query: 112 ----WLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
               +  L +L  +  +RK +ADP+ SY AKLY  G     +K+ EE  E A A     R
Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181

Query: 167 ---------------------FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                                +++  E +DL++H++V L   G+    ++  L +R+
Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238


>UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria
           RepID=Q2JWX9_SYNJA
          Length = 231

 Score =  141 bits (356), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 82/195 (42%), Positives = 110/195 (56%), Gaps = 11/195 (5%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ  + G VLM+ +MN E+L KTLE+G+  F+SR++Q LW KGETSG+   V  
Sbjct: 34  GLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQWVKQ 93

Query: 77  IAPDCDNDTLLVLANPIG-PTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAERKS 127
           I  DCD+D L++L   +G   CH G  SCF        GD       L Q+  ++  R+ 
Sbjct: 94  IRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKARQ- 152

Query: 128 ADPET-SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           ADP   SYT+ L A G   I +K+GEE  E  +AA   D+  L  E +DL YH LV L  
Sbjct: 153 ADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVALAH 212

Query: 187 QGLDLTTVIENLRKR 201
             +D+  V   L+ R
Sbjct: 213 HQVDIRDVYRQLQAR 227


>UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Picrophilus torridus
           RepID=Q6KZD6_PICTO
          Length = 204

 Score =  138 bits (348), Expect = 9e-32,   Method: Compositional matrix adjust.
 Identities = 74/199 (37%), Positives = 113/199 (56%), Gaps = 13/199 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DG++PV+VQ   +G+VL L YM+  AL+ T+++G   ++SR+ +R+  KGE SGN   V
Sbjct: 9   NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF----------GDTAHQWLFLYQLEQLLAE 124
           + I  DC++++LL+     GP CH G +SCF          G+  +    L +LE L+ +
Sbjct: 69  MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R       SYT  L  SG + I +KVGEE +ET LA+    R  +  E +DL+YHL+V L
Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILASG---RDRIVYETADLLYHLIVFL 185

Query: 185 QDQGLDLTTVIENLRKRHQ 203
               + L  V+  L +R +
Sbjct: 186 AFNNVSLFDVMNELNRRSK 204


>UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP
           pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN
          Length = 215

 Score =  137 bits (346), Expect = 2e-31,   Method: Compositional matrix adjust.
 Identities = 86/196 (43%), Positives = 114/196 (58%), Gaps = 7/196 (3%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++  LW KG  SGN   V
Sbjct: 10  ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKGAISGNTQEV 69

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL--FLYQLEQLLAERKS 127
           + +  DCD D +L    P GP CH G  +CF      +TA   L   L ++ + L  R  
Sbjct: 70  LEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKVYRTLRSRLR 129

Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
             PE SY  K++ +G  RI +K+GEE  E  +AA    R EL  EASDL++HLL  L + 
Sbjct: 130 ERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLFHLLFTLTEL 189

Query: 188 GLDLTTVIENLRKRHQ 203
           GL    +   L +R+Q
Sbjct: 190 GLSPQDLARVLWERNQ 205


>UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae
           RepID=C4V2J2_9FIRM
          Length = 235

 Score =  136 bits (343), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 78/204 (38%), Positives = 114/204 (55%), Gaps = 19/204 (9%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   + +VLML YMN E+L+KT+E+G   ++SR++Q+LW KGETSGN   +  
Sbjct: 15  GLVPAIVQEE-NNQVLMLAYMNRESLEKTIETGFAWYYSRSRQKLWKKGETSGNVQRIKE 73

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFG-----DTAHQWLF-------------LYQL 118
           I+ DCD DT+L+     G  CH GT SCF      D   + +              L  L
Sbjct: 74  ISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIPLIEKEEHPLTEVLASL 133

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            Q++  R+    E SYT  L+  G  +I +K+GEE  ET +A+  + R ++  E  DL Y
Sbjct: 134 YQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASKNNIREDVLYEMGDLWY 193

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           H LVLL    +    ++E L++R+
Sbjct: 194 HCLVLLAYHNMTPEDLLEELKRRN 217


>UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta
           RepID=HIS2_ARATH
          Length = 281

 Score =  136 bits (343), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 79/206 (38%), Positives = 117/206 (56%), Gaps = 24/206 (11%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL   I Q+  +G VLM G++N EAL  T+ S K TFFSR++  LWTKGETS NF+N++ 
Sbjct: 65  GLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTLWTKGETSNNFINILD 124

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-------------FLYQLEQLLA 123
           +  DCD D+++ L  P GPTCH G  +C+  +    L              LY LE +++
Sbjct: 125 VYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGNKLALTTLYSLESIIS 184

Query: 124 ERK--SADPE---TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT---NEASD 175
           +RK  S  P+    S+T +L       +  K+ EE  E  L  T+ D  E++   +E +D
Sbjct: 185 KRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADE--LCRTLEDNEEVSRTPSEMAD 241

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           ++YH +VLL  +G+ +  V+E LRKR
Sbjct: 242 VLYHAMVLLSKRGVKMEDVLEVLRKR 267


>UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_THET2
          Length = 214

 Score =  135 bits (340), Expect = 9e-31,   Method: Compositional matrix adjust.
 Identities = 73/168 (43%), Positives = 100/168 (59%), Gaps = 13/168 (7%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGETSG+   VV 
Sbjct: 12  GLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVE 71

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF---------LYQLEQLLAERKS 127
           +  DCD D ++    P GP CH G  +CF    H+ L          + Q+   + ER  
Sbjct: 72  VLLDCDGDAVVYRVLPQGPACHTGERTCF----HRALLEGEKDLGFVVGQVYATIKERLR 127

Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             PE SY A+++ +G  RI +K+GEE  E  LAA   +  EL +EA+D
Sbjct: 128 TLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAAD 175


>UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS
          Length = 257

 Score =  133 bits (335), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 82/227 (36%), Positives = 115/227 (50%), Gaps = 42/227 (18%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I QH  +G +LM+ +MN E+L  T E  +  +FSR++Q+LW KGE SG+F  V  
Sbjct: 16  GLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQKLWHKGEESGHFQTVYE 75

Query: 77  IAPDCDNDTLLV-LANPIGPTCHKGTSSCF-----------------------GDTA--- 109
           I  DCD D +++ +    G  CH G  SCF                       GD A   
Sbjct: 76  IRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDAQLKDPTAIYGDNAKTE 135

Query: 110 --------HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
                    Q   L  L QL+ ERK A+ +TSY + LY  G  +I +KVGEEGVET +AA
Sbjct: 136 SHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINKILEKVGEEGVETIIAA 195

Query: 162 -------TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                  T  +  +L  E +DL +H +V+L    L+   +I+ L +R
Sbjct: 196 KDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDELGRR 242


>UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria
           RepID=HIS2_HELHP
          Length = 231

 Score =  133 bits (335), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 73/213 (34%), Positives = 114/213 (53%), Gaps = 20/213 (9%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
           R++DWE+ + L+P IVQ   S ++LML Y + ++L+ +L++    +FSR+KQR+W KGE 
Sbjct: 6   RQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQKGEQ 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-----DTAHQ----------- 111
           SG+  ++  +  DCDND+L+ +   +G  CH G  SCF      D   Q           
Sbjct: 65  SGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMPQKYP 124

Query: 112 ---WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
              +  L  L  ++ +R+  + E SYTA L A G   I +K+ EE  E   A    D   
Sbjct: 125 IGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDKDEKA 184

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +  E +DL YH+LV L  + +    V++ LR+R
Sbjct: 185 IIYECADLFYHILVGLALEHITPERVLQELRRR 217


>UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2
           Tax=Campylobacter RepID=B9D5P8_WOLRE
          Length = 329

 Score =  133 bits (334), Expect = 4e-30,   Method: Compositional matrix adjust.
 Identities = 77/181 (42%), Positives = 102/181 (56%), Gaps = 29/181 (16%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P +VQ + SGEVLML YMN EAL+ +L++G   +FSRTK R+W KGE S
Sbjct: 2   KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLV-LANPIGPTCHKGTSSCF-------GDTAH------QWLF 114
           GN   +  I  DCDNDT+L+ +    G  CH G  SCF       GD ++      Q L 
Sbjct: 62  GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121

Query: 115 LYQLEQL--------------LAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
             QL Q               + +RK +ADP+TSY A L+  G   I +KVGEE  E  +
Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181

Query: 160 A 160
           A
Sbjct: 182 A 182


>UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4L5_GEMAT
          Length = 207

 Score =  133 bits (334), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 80/195 (41%), Positives = 112/195 (57%), Gaps = 5/195 (2%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++  LW KG TSG
Sbjct: 10  LDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG-LWHKGATSG 68

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA- 128
           +   V+S+A DCD D +L      GP CH GT+SCF DTA     +  L+  +A R+ + 
Sbjct: 69  HVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDTTIAARQQSL 128

Query: 129 --DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
             D   SYT +L      R+ +K+GEE VE A A    D    T E +DL+YH LV L+ 
Sbjct: 129 RDDERPSYTQRLLTDRNLRL-KKLGEEAVELATACVDGDVERATEETADLLYHALVALRA 187

Query: 187 QGLDLTTVIENLRKR 201
            G  L  V   L +R
Sbjct: 188 TGGTLDGVRGVLAQR 202


>UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KI1_SYMTH
          Length = 210

 Score =  132 bits (333), Expect = 5e-30,   Method: Compositional matrix adjust.
 Identities = 82/199 (41%), Positives = 106/199 (53%), Gaps = 25/199 (12%)

Query: 28  SGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLL 87
           +G+VLM  YMN EAL  TLE+G   ++SR++Q LW KG TSG+   V  I  DCD D+LL
Sbjct: 3   TGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSLL 62

Query: 88  VLANPIGPTCHKGTSSCFG-----------DTAHQWL------------FLYQLEQLLAE 124
           +L    G  CH+GT SCF            DTA   +             L +L  +LAE
Sbjct: 63  LLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLAE 122

Query: 125 RKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           R++  DPE SYT++L+  G     +K+GEE  E  LA    DR  L  E +DL +H LV 
Sbjct: 123 RRAHPDPE-SYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181

Query: 184 LQDQGLDLTTVIENLRKRH 202
           L DQGL    V + L  R 
Sbjct: 182 LVDQGLSPADVADQLASRR 200


>UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius LAA1 RepID=B7DRK3_9BACL
          Length = 254

 Score =  131 bits (330), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 80/239 (33%), Positives = 116/239 (48%), Gaps = 49/239 (20%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           ++   GL+PV+ Q A +GEVLM+ Y + EAL +TL +G   ++SR+++  W KG TSGN 
Sbjct: 15  YDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRREYWRKGATSGNA 74

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-------------------------- 105
             VV +  DCD D +L    P GP CH G  +CF                          
Sbjct: 75  QRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAADEGGAKDVGGGA 134

Query: 106 ----------GDTAHQ------W--LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIA 147
                      DT+ +      W    L +L  ++  R    P+ SYT  L+  G +R+ 
Sbjct: 135 DVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTTYLFTHGAERMG 194

Query: 148 QKVGEEGVETALAATVHDR-----FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+    V   L KR
Sbjct: 195 KKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHPVDVWRTLEKR 253


>UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WUY1_ALIAD
          Length = 256

 Score =  131 bits (329), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 79/244 (32%), Positives = 113/244 (46%), Gaps = 54/244 (22%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           ++   GL+PV+ Q A +G+VLML Y + EAL +TL +G   ++SR+++  W KG TSGN 
Sbjct: 12  YDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRAYWRKGATSGNV 71

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-------------------------- 105
             VV +  DCD D +L    P GP CH G   CF                          
Sbjct: 72  QRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAADESGPDPHGAAG 131

Query: 106 -----------------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASG 142
                                  G  A     L +L  ++  R    P+ SYT  L+  G
Sbjct: 132 AGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPDGSYTTYLFTHG 191

Query: 143 TKRIAQKVGEEGVETALAATVHDR-----FELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
            +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+    V + 
Sbjct: 192 AERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRHVGVQPADVWQV 251

Query: 198 LRKR 201
           L KR
Sbjct: 252 LEKR 255


>UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3
           Tax=Clostridiales RepID=C4Z9Z2_EUBR3
          Length = 427

 Score =  130 bits (326), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%)

Query: 1   MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           +L +    +L W      +DG++PVIVQ   + +VLML YMN EA + T+ SG++T++SR
Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108
           ++  LWTKG TSG+   V S+  DCD DT+L   + +G  CH    +CF +         
Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            +    L  +  ++ +R     E SYT  +   G   I +K+G E  E  LAA   D  +
Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           L  E SD MYH ++L+  + +    +   L +R
Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427


>UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
           n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD
          Length = 202

 Score =  130 bits (326), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 76/197 (38%), Positives = 110/197 (55%), Gaps = 9/197 (4%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+   W KG TSG
Sbjct: 7   LDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRG-PWHKGATSG 65

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA- 128
           N   VV++  DCD D +L      GP CH GT +CFG    +W  L  L+  LA R +  
Sbjct: 66  NVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFG--PGRWDALSALDDTLARRAAPA 123

Query: 129 ----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
               D   SYT +L      R+ +K+GEE  E   A    D      EA+D++YH+LV +
Sbjct: 124 ERPDDAPPSYTRRLLEDRNLRL-KKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVAV 182

Query: 185 QDQGLDLTTVIENLRKR 201
           +  GL L  V   L +R
Sbjct: 183 RPLGLSLDDVKAVLARR 199


>UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8HTA8_CHLRE
          Length = 308

 Score =  125 bits (314), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 75/222 (33%), Positives = 121/222 (54%), Gaps = 33/222 (14%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           L W+K + L+ VIVQH  +GEV+M  + +  A+ +TL++G  TF+SR++   W KGETSG
Sbjct: 72  LKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCKGETSG 130

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----------------------G 106
           +F+NV ++  DCD D+++ L++PIGP CH G  +C+                       G
Sbjct: 131 HFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGAHDDGG 190

Query: 107 DTAHQWLFLYQLEQLLAERKSA------DPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
           D   +   L  LE+ +A+R+ A        + S+TA+L  +  + + +K+ EE  E    
Sbjct: 191 DHVPRTTLLT-LERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGELCQT 248

Query: 161 ATVHD-RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               + R    +E +DL+YH +VL   QG+ +  V+  LRKR
Sbjct: 249 LEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290


>UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms
           RepID=HIS2_SYNPX
          Length = 222

 Score =  120 bits (301), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 70/198 (35%), Positives = 103/198 (52%), Gaps = 13/198 (6%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q  + G VLM+ +MN E++ +TL SG+  ++SR++Q LW KG TSG+   + S
Sbjct: 18  GLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQELWHKGATSGHTQTLRS 77

Query: 77  IAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWL------------FLYQLEQLLA 123
           I  DCD D LL+     G   CH G  SCF +   Q                 +L +++ 
Sbjct: 78  IRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNALSPPADACTELFRVIE 137

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R+    E SYT KL   G  +I +K+GEE  E  +A    +  E+  EA+D+++H+ V 
Sbjct: 138 SRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEEIAGEAADILFHMQVA 197

Query: 184 LQDQGLDLTTVIENLRKR 201
           L   G+    V E L  R
Sbjct: 198 LAHHGVSWRQVQEVLAAR 215


>UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU
          Length = 284

 Score =  119 bits (299), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 75/218 (34%), Positives = 114/218 (52%), Gaps = 44/218 (20%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  I Q   +G +LM G+ + +A+  TL + K TF+SR++  LW KGETSGNF+ V S
Sbjct: 56  GLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCKGETSGNFIGVES 115

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF----------------GDTAHQWLF--LYQL 118
           +  DCD D+L+ L  P GPTCH G  +C+                G  A +     LY+L
Sbjct: 116 VHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRHAAEEALTTLYEL 175

Query: 119 EQLLAERK----SADPETSYTAKLYASG---TKRIAQKVGE--------EGVETALAATV 163
           E  +  R+    + D + S+T +L  +     K+I ++ GE        EG E A     
Sbjct: 176 EATIEARRVEAVADDVKPSWTRRLLDNPELLCKKIREEAGELCQTWEENEGKEAA----- 230

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                 TNE +D++YH +V+L  QG+ ++ V+  LR+R
Sbjct: 231 ------TNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262


>UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=C4XTP1_DESMR
          Length = 124

 Score =  113 bits (283), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 54/96 (56%), Positives = 67/96 (69%), Gaps = 1/96 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           D+ K  GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+
Sbjct: 5   DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105
              V S+  DCD DT+LVL   I G  CH+G  SCF
Sbjct: 65  VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCF 100


>UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum
           sp. NBC37-1 RepID=A6Q6T8_SULNB
          Length = 222

 Score =  112 bits (281), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +DW K + L+P I Q A + +VLML YMN EA + TL +G   +FSR+KQR+W KGE+SG
Sbjct: 3   IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115
           +   V  +  DCD DT+++     G  CH G  SCF               DT   +  +
Sbjct: 62  HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121

Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
             L   + ERK+A  E  S+T KL     + +  K+ EE  E  +A       ++  E++
Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV L  + +    V + L +R
Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207


>UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P0M4_9BACE
          Length = 108

 Score =  112 bits (281), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 49/88 (55%), Positives = 66/88 (75%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+PVI+Q A + EVLMLG+ N EA++ TL++    F+SR++Q+LW KGETSG+FL+V  +
Sbjct: 13  LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHFLHVERM 72

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF 105
             DCD DTLL   +P+GPTCH G  SCF
Sbjct: 73  VTDCDTDTLLYFCHPVGPTCHTGAKSCF 100


>UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales
           RepID=C4Z0A8_EUBE2
          Length = 362

 Score =  112 bits (279), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 50/98 (51%), Positives = 66/98 (67%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GL+PV+VQ  V+ EVLML YMN EA +KTLE+G +T++SR++Q LW KG TSG+F  V
Sbjct: 263 ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQYV 322

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112
            S+  DCDNDT+L     +G  CH G  +CF      W
Sbjct: 323 GSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTW 360


>UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms
           RepID=HIS3_SOLUE
          Length = 126

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 57/129 (44%), Positives = 80/129 (62%), Gaps = 7/129 (5%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LD+ K+DGL+  ++Q   SG VLM+GYMN EA +KT+E+G  TF+SR++++LW KGE+SG
Sbjct: 3   LDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESSG 62

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           + L V  I+ DCD D +LV     GP  CH+G  SCF      +  L   E  +A+  + 
Sbjct: 63  HRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCF------FRRLDAGEWKVADNPTY 116

Query: 129 DPETSYTAK 137
           DP   Y  K
Sbjct: 117 DPGAVYGGK 125


>UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota
           RepID=HIS3_HALWD
          Length = 132

 Score =  107 bits (266), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 53/121 (43%), Positives = 71/121 (58%), Gaps = 9/121 (7%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+P I Q A SGEVLML Y++P AL +T E+G+  ++SR+++ LW KGETSG+  +
Sbjct: 20  NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWKKGETSGHTQH 79

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
           +  I  DCD DT+L L    G  CH G  SCF  T         L+      +  DPET 
Sbjct: 80  IREIRADCDADTILYLVEQTGGACHTGHQSCFYRT---------LDGTEVTERVFDPETV 130

Query: 134 Y 134
           Y
Sbjct: 131 Y 131


>UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales
           RepID=HIS3_ERYLH
          Length = 125

 Score =  105 bits (263), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 45/91 (49%), Positives = 61/91 (67%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+  +VQH  + EVLM+ +MN +ALD T ++G   FFSR++Q LW KG TSGN L V
Sbjct: 21  SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAV 80

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
             +  DCD D +++L  P GP CH G  +CF
Sbjct: 81  SQVLVDCDQDAVILLVEPAGPACHTGARTCF 111


>UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1
           RepID=A3WCC9_9SPHN
          Length = 143

 Score =  105 bits (263), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 47/89 (52%), Positives = 63/89 (70%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  +V  + + EVL++ +MN +AL KT E+GKV F+SR++  LW KGETSGN L+V  
Sbjct: 37  GLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGNVLSVDE 96

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           I  DCD D L++ A P GPTCH G +SCF
Sbjct: 97  IRVDCDQDALVIYATPAGPTCHTGETSCF 125


>UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G191_ABIDE
          Length = 295

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 48/92 (52%), Positives = 60/92 (65%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   +G VL + YMN E+L+ TL      F+SR+++ LW KGETSGN+ +VVS
Sbjct: 27  GLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGETSGNYQHVVS 86

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           I  DCD D LLV     G  CH+G  SCF DT
Sbjct: 87  IEADCDYDALLVRVVRDGAACHRGNESCFDDT 118


>UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria
           RepID=HIS3_DINSH
          Length = 119

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 44/89 (49%), Positives = 61/89 (68%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q  W KGE+SG+   +V 
Sbjct: 14  GLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGESSGHVQTLVE 73

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +  DCD D LL+     GP CH    +CF
Sbjct: 74  MRVDCDRDCLLLQVRQEGPACHTNRRTCF 102


>UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268
           RepID=C8PI34_9PROT
          Length = 336

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 51/98 (52%), Positives = 62/98 (63%), Gaps = 1/98 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P IVQ A  G VLML YMN EAL  TL +G   +FSR+K R+W KGE S
Sbjct: 2   KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLV-LANPIGPTCHKGTSSCF 105
           G+   V S   DCDND LL+ +    G  CH G  SCF
Sbjct: 62  GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCF 99


>UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F746
          Length = 123

 Score =  103 bits (258), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 48/103 (46%), Positives = 67/103 (65%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T +  REL    +DGL+PVIVQ   + EVLM+ +M+ EA+++TL +G   ++SR++Q  W
Sbjct: 13  TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            KGETSGN   V S++ DCD D LL+     GP CH  T +CF
Sbjct: 73  VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCF 115


>UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria
           RepID=HIS3_SILST
          Length = 129

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 43/89 (48%), Positives = 60/89 (67%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q   SGE+LM+ +MN E++ KTLE+G+VT++SR++Q  W KGE+SG+   +V 
Sbjct: 24  GLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQELVE 83

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +  DCD D LL +    GP CH    SCF
Sbjct: 84  LRVDCDRDALLAMVRQTGPACHTNRRSCF 112


>UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM
           16069 RepID=C7RAI7_KANKD
          Length = 412

 Score =  102 bits (255), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 69/194 (35%), Positives = 105/194 (54%), Gaps = 8/194 (4%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LD++K   L+P IVQ   +G VLML Y  PE+L   +   K  +FSR++  LW KG TSG
Sbjct: 224 LDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNELWEKGLTSG 282

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLEQLLAERKSA 128
           N   +++I  DCD DTL+      G  CH    SCF G +A+    L  L+++  +R  +
Sbjct: 283 NQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSAN--FDLDVLDRVFEQRMQS 340

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
              TS++ KL AS   +  +K+ EE  E   A    D+ E+  EA+DL++  L   + +G
Sbjct: 341 QEVTSFSQKLLASDDLQ-QEKLREECEELIEA---DDQDEVRWEAADLIFFALARAKSKG 396

Query: 189 LDLTTVIENLRKRH 202
           +  + +I  L  R+
Sbjct: 397 VAASDIINELGARN 410


>UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae
           RepID=HIS3_FRAAA
          Length = 132

 Score =  102 bits (254), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 46/89 (51%), Positives = 62/89 (69%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL P I Q   +GEVLMLG+M+ EAL +TL +G+ T++SR++   W KG+TSG+   V S
Sbjct: 22  GLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQWVRS 81

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +A DCD D +LV  + IGP CH GT +CF
Sbjct: 82  VALDCDGDAVLVRVDQIGPACHTGTRNCF 110


>UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria
           RepID=Q2SLC2_HAHCH
          Length = 139

 Score =  102 bits (253), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 43/89 (48%), Positives = 63/89 (70%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PVI Q A +  +LM  +MN EAL+KT+ + ++T++SR++QRLW KGETSG+   +VS
Sbjct: 33  GLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWVKGETSGHVQRLVS 92

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           ++ DCD D +L L +  G  CH G  +CF
Sbjct: 93  MSFDCDGDAILCLVDQQGAACHTGRQTCF 121


>UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides
           RepID=Q03VY1_LEUMM
          Length = 132

 Score =  102 bits (253), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 47/93 (50%), Positives = 60/93 (64%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+P ++  A +   LMLGYMN E+   T  +G+  F+SR +Q LW KGETSGN   VV
Sbjct: 14  NGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQELWHKGETSGNIQQVV 73

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           S+  DCD DTLL+  NP GP CH    SCF +T
Sbjct: 74  SMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNT 106


>UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class)
           RepID=HIS3_CLAMS
          Length = 138

 Score =  101 bits (252), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 52/114 (45%), Positives = 71/114 (62%), Gaps = 8/114 (7%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P ++Q   + EVLMLGYM+ EAL +TL +G+VTF+SR++   W KG+TSG+   V 
Sbjct: 28  DGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYWRKGDTSGHGQYVR 87

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
             A DCD DT+LV  + +G  CH GT +CF D  H       L  +   R +AD
Sbjct: 88  DAALDCDGDTVLVQVDQVGVACHTGTRTCF-DADH-------LHPVTGARPAAD 133


>UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13
           RepID=B6BVA2_9PROT
          Length = 129

 Score =  101 bits (251), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 47/90 (52%), Positives = 64/90 (71%), Gaps = 1/90 (1%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I+Q   S +V+M+ +MN EAL KT+E+ +  F+SR++ ++W KGE SGNF NVVS
Sbjct: 13  GLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLKGEESGNFHNVVS 72

Query: 77  IAPDCDNDTLLVLAN-PIGPTCHKGTSSCF 105
           I  DCD D+LLV  N   G +CH G +SCF
Sbjct: 73  ILVDCDIDSLLVKVNVKSGISCHTGRNSCF 102


>UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria
           RepID=HIS3_THICR
          Length = 147

 Score =  101 bits (251), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 48/114 (42%), Positives = 64/114 (56%), Gaps = 8/114 (7%)

Query: 5   QQRRELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           QQ    DWE          +GL+P I Q   S EVLM+ +MN  AL +TLE+G+V ++SR
Sbjct: 14  QQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSR 73

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH 110
           ++Q  W KGE SG    +  +  DCD D +L+L +  GP CH G  SCF    H
Sbjct: 74  SRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIH 127


>UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae
           RepID=HIS3_ACIC1
          Length = 142

 Score =  100 bits (250), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 45/89 (50%), Positives = 62/89 (69%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL P + Q   +GEVLM+G+M+ EAL +TL +G+ T++SR++Q  W KGETSG+   V S
Sbjct: 22  GLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQWVKS 81

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +A DCD DT+LV  + IG  CH G  +CF
Sbjct: 82  VALDCDGDTVLVKVDQIGAACHTGDRTCF 110


>UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria
           RepID=HIS3_CHRSD
          Length = 146

 Score =  100 bits (250), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 47/99 (47%), Positives = 64/99 (64%), Gaps = 5/99 (5%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q   SGEVLM+ +MN  AL++TL +G+V ++SR++ + W KGE+SG    +V+
Sbjct: 32  GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPWRKGESSGQVQQLVT 91

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAH 110
              DCD DTLL+  +  GP CH G  SCF      DTAH
Sbjct: 92  AHLDCDGDTLLLGVDQQGPACHTGRRSCFYVALGADTAH 130


>UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria
           RepID=A4GIE4_9BACT
          Length = 132

 Score =  100 bits (249), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 41/90 (45%), Positives = 64/90 (71%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P I Q   +GEVLM+ +MN  +L +TL +G++ ++SR+++ LW KG+TSG+   ++
Sbjct: 16  DGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKLI 75

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            +  DCD D++LVL +  G  CH+GT SCF
Sbjct: 76  ELRYDCDADSILVLVDQSGAACHEGTRSCF 105


>UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria
           RepID=HIS3_BIFLI
          Length = 136

 Score =  100 bits (249), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 44/89 (49%), Positives = 61/89 (68%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  ++Q   + EVLM+GYMN EAL +TL +G+VTF+SR++Q  W KG+TSG+   V  
Sbjct: 26  GLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQYVKG 85

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           ++ DCD D LLV  + +G  CH G  SCF
Sbjct: 86  VSLDCDGDALLVEVDQVGAACHTGKRSCF 114


>UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_STRTD
          Length = 112

 Score =  100 bits (248), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 47/97 (48%), Positives = 64/97 (65%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD++K  GL+PVIV    +G+VLML YMN  +   TLE+ ++ ++SR++  LW KG TS
Sbjct: 5   KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           G+F +V SI  DCD DTLL+     G  CH G  SCF
Sbjct: 65  GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCF 101


>UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4CVB3_9BACT
          Length = 128

 Score = 99.8 bits (247), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 53/125 (42%), Positives = 71/125 (56%), Gaps = 10/125 (8%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P IVQ   +  VLM+ +MN  +L+ TL++G + ++SR++Q+ W KGETSG+   VV
Sbjct: 11  DGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGETSGHTQKVV 70

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL---LAERKSADPET 132
             A DCD DTLL     IG  CH G  SCF          Y  E     + E K  DPE 
Sbjct: 71  RWAVDCDADTLLFEVEQIGGACHTGFESCFFQA-------YSPEGTPLEITEEKLFDPEK 123

Query: 133 SYTAK 137
           +Y +K
Sbjct: 124 TYASK 128


>UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_GEOSF
          Length = 126

 Score = 99.4 bits (246), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 45/98 (45%), Positives = 64/98 (65%), Gaps = 1/98 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   SGEVLM+ +M+ + LD TL+ GK  FFSRT+ + W KGE S
Sbjct: 3   KIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGEES 62

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105
           GN   V+ +  DCD DT+++     GP  CH G  SCF
Sbjct: 63  GNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCF 100


>UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms
           RepID=HIS3_PELLD
          Length = 137

 Score = 98.6 bits (244), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 44/89 (49%), Positives = 61/89 (68%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   +G+VLM+ +MN E+L+ TLE  K  ++SR++ +LW KGE+SGN  +V  
Sbjct: 21  GLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLKGESSGNMQDVYD 80

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           I  DCD DTL++  + IG  CH G  SCF
Sbjct: 81  ILIDCDGDTLILKVSQIGGACHVGYHSCF 109


>UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3
          Length = 140

 Score = 98.6 bits (244), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 44/90 (48%), Positives = 59/90 (65%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+P I Q   +G+VLML YMN E+L+ TL+  K  ++SR++Q LW KG TSGNF  V+
Sbjct: 20  NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLKGATSGNFQEVM 79

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            I+ DCD D +L+     G  CH G  SCF
Sbjct: 80  QISIDCDADAILLKVKQKGGACHVGYYSCF 109


>UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria
           RepID=HIS3_BACCN
          Length = 101

 Score = 98.2 bits (243), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 43/91 (47%), Positives = 61/91 (67%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P IV +  + EVLML YMN EA +KTL++ K  F+SR++Q LW KG TSG+  +V
Sbjct: 6   SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            S+  DCD D +++  N +G  CH G  +CF
Sbjct: 66  KSLYLDCDQDAIVITVNQVGVACHTGEKTCF 96


>UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria
           RepID=HIS3_ACIAC
          Length = 141

 Score = 97.8 bits (242), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 49/101 (48%), Positives = 63/101 (62%), Gaps = 5/101 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           E+ W+   GL+PVI Q A +G+VLM  +MN EAL KT E G+  +FSR++ RLW KGE S
Sbjct: 18  EVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGEES 76

Query: 69  GNFLNVVSIAPDCDNDTLLV----LANPIGPTCHKGTSSCF 105
           G+   V  I  DCDND +L+    L +  G  CH G  SCF
Sbjct: 77  GHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCF 117


>UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria
           RepID=B8J3P0_DESDA
          Length = 137

 Score = 97.8 bits (242), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 43/92 (46%), Positives = 64/92 (69%), Gaps = 1/92 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P I Q   SGEVLML YMN EA  KTLE+G+  ++SR+++++W KG TSG+   V
Sbjct: 21  SKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGHIQKV 80

Query: 75  VSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105
           +++  DCD+DT+L+  + + G  CH G  +CF
Sbjct: 81  LAVRLDCDSDTVLLFVDQVGGAACHTGRRTCF 112


>UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM
          Length = 151

 Score = 97.8 bits (242), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 46/102 (45%), Positives = 64/102 (62%), Gaps = 3/102 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P + Q A +G+VLML +MN  A++KTLE+G++T+FSR++  LW KG  SGN   +V 
Sbjct: 44  GLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVKGLASGNHQQLVE 103

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF---GDTAHQWLFL 115
              DCD D LL      G  CH G  SCF    + A+Q ++L
Sbjct: 104 ARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145


>UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RPU9_FIBSS
          Length = 116

 Score = 97.4 bits (241), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 46/96 (47%), Positives = 60/96 (62%), Gaps = 2/96 (2%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L P IVQ A  G+VLM+ +MN EAL +T E G++ F+SR+++  W KG+TSGN + VV  
Sbjct: 21  LAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRSRKEYWHKGDTSGNVMTVVEW 80

Query: 78  APDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111
           A DCD+D LL      GP   CH G  SCF  T  +
Sbjct: 81  AADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116


>UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii
           'Deep ecotype' RepID=B4RV64_ALTMD
          Length = 133

 Score = 97.1 bits (240), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 44/90 (48%), Positives = 60/90 (66%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+PVI Q   S +VLM  +M+ E+LD+TL +GK+ ++SR++Q LW KG +SG+   V 
Sbjct: 31  DGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWRKGSSSGHSQTVK 90

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           SIA DCD D LL   + +G  CH    SCF
Sbjct: 91  SIAADCDGDVLLAEVSQVGFACHTRRHSCF 120


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score = 97.1 bits (240), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 11/204 (5%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT++   E+  ++ DGL   +V        L L Y + +++ K ++ G+  ++SR++  
Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           +W KGETSGN   ++ I+ DCD+D L  +V    +G  CH  T SCFG+  H    L  L
Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVG-FCHLETMSCFGEFKHG---LVGL 248

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E LL +R    PE SYT +L+ + +  +  K+ EE  E   A     + EL+ EA+DL Y
Sbjct: 249 ESLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFY 304

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
             L  L    + L  V  NL  +H
Sbjct: 305 FALAKLVANDVSLKDVENNLNMKH 328


>UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_CHLP8
          Length = 137

 Score = 95.9 bits (237), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 44/89 (49%), Positives = 59/89 (66%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   +G+VLM+ +MN E+L  TLE  K  ++SR++ +LW KGE+SGN  +V  
Sbjct: 21  GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWLKGESSGNMQDVHD 80

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           I  DCD DTLL+  +  G  CH G  SCF
Sbjct: 81  IMIDCDGDTLLLKVSQKGGACHVGYHSCF 109


>UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured
           crenarchaeote RepID=Q702A1_9CREN
          Length = 115

 Score = 95.9 bits (237), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 42/97 (43%), Positives = 62/97 (63%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD+ K DGL+PV+VQ   + ++LML Y N  A++ T+++G   F+S ++ +LW KGE S
Sbjct: 12  KLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWMKGEES 71

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           GN   V  I  DCD D++L L +   P CH G  +CF
Sbjct: 72  GNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCF 108


>UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_RHOPS
          Length = 147

 Score = 95.1 bits (235), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 41/89 (46%), Positives = 59/89 (66%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  +   A SGEVLM+ +MN EAL+KT++SG+  ++SR+++RLW KGE+SG+   V+ 
Sbjct: 28  GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGHVQRVLE 87

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           I  DCD D + +     G  CH G  SCF
Sbjct: 88  IRVDCDQDAVWLRVEQAGAACHTGRQSCF 116


>UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca
           ATCC 27029 RepID=D1SGQ9_9ACTO
          Length = 444

 Score = 94.4 bits (233), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 43/90 (47%), Positives = 59/90 (65%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+  +V+   SGEVLM+ +M+ EAL +TL +G+ T++SR++   W KG TSGN   V 
Sbjct: 342 DGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQYVR 401

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           S+A DCD D LLV    +G  CH G  +CF
Sbjct: 402 SVALDCDGDALLVSVEQVGAACHTGQRTCF 431


>UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC
           23134 RepID=A1ZDC3_9SPHI
          Length = 130

 Score = 94.4 bits (233), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 46/101 (45%), Positives = 63/101 (62%), Gaps = 7/101 (6%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           +EK  GL+PV+VQ   SG+VLMLGY N  AL +TL++G  TF+S ++  LWTKG+TSG++
Sbjct: 15  FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74

Query: 72  LNVVSIAPDCDNDTLLVLANPIGP-TCH------KGTSSCF 105
           L +  I  DCD D L+     +G   CH      +   SCF
Sbjct: 75  LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCF 115


>UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms
           RepID=C7NRL7_HALUD
          Length = 138

 Score = 94.0 bits (232), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 42/87 (48%), Positives = 55/87 (63%)

Query: 19  MPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIA 78
           +P + Q A SG+VLML Y+  EALD+T E+G   ++SR++  LW KGETSGN  ++  I 
Sbjct: 31  LPAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETSGNVQHLKEIR 90

Query: 79  PDCDNDTLLVLANPIGPTCHKGTSSCF 105
            DCD D LL +    G  CH G  SCF
Sbjct: 91  VDCDGDALLYVIEQDGGACHTGFQSCF 117


>UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum
           ATCC BAA-798 RepID=D1CF76_THET1
          Length = 300

 Score = 93.6 bits (231), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 42/90 (46%), Positives = 66/90 (73%), Gaps = 1/90 (1%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W KGETSG  L+V  
Sbjct: 20  GLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLKGETSGRTLHVRE 79

Query: 77  IAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105
           + P+C+ ++LL+L +   P  CH G  SCF
Sbjct: 80  LRPNCELNSLLILVDQRLPGACHTGHFSCF 109


>UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria
           RepID=HIS3_SALRD
          Length = 127

 Score = 93.2 bits (230), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 42/90 (46%), Positives = 58/90 (64%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P IVQ A + +VLM+ YM  E L +TL++G++ ++SR++Q  W KG+TSG+   V 
Sbjct: 14  DGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQERWVKGQTSGHTQTVE 73

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
               DCD DTLL   +  G  CH G  SCF
Sbjct: 74  EARLDCDGDTLLFRVHQEGGACHTGFRSCF 103


>UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ
          Length = 149

 Score = 92.8 bits (229), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 44/93 (47%), Positives = 60/93 (64%), Gaps = 2/93 (2%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+P IV  A SG VLM  +MN +AL +T+ +G   F+SR++ +LW KGE SGN L+V
Sbjct: 29  SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88

Query: 75  VSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCF 105
             +  DCD D + +LA+    G  CH G  SCF
Sbjct: 89  KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCF 121


>UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7
           genomosp. GTL1 RepID=A5KSK8_9BACT
          Length = 125

 Score = 92.8 bits (229), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 46/83 (55%), Positives = 55/83 (66%), Gaps = 3/83 (3%)

Query: 26  AVSG--EVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS-IAPDCD 82
           AV G   + M GYMN  A++ TL  G VTFFSRT  +LW KGETSGN L +   I  DCD
Sbjct: 40  AVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWKKGETSGNILRLRGDIYVDCD 99

Query: 83  NDTLLVLANPIGPTCHKGTSSCF 105
            D+LL+ A P+G TCH G+ SCF
Sbjct: 100 GDSLLINAEPVGSTCHTGSQSCF 122


>UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria
           RepID=HIS2_LEPBJ
          Length = 92

 Score = 92.8 bits (229), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 48/89 (53%), Positives = 61/89 (68%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
           FL QLE +L +RK   P+ SYTA L+  G  RI +KVGEE  E  +AA   D+ ELT+EA
Sbjct: 3   FLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEA 62

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL VLL +Q L L  V+E LRKRH
Sbjct: 63  ADLLFHLQVLLVEQELSLQDVVEELRKRH 91


>UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium
           HTCC2255 RepID=Q0FGM5_9RHOB
          Length = 120

 Score = 92.4 bits (228), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 41/90 (45%), Positives = 58/90 (64%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+P +VQ   + EVLM+ +MN  +L+KT E+   TF+SR+++ LW KG TSGN   V 
Sbjct: 14  NGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGLTSGNTQKVD 73

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            +  DCD D +L+L  P GP CH    +CF
Sbjct: 74  KVRFDCDRDCILLLVTPEGPACHTNRRNCF 103


>UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales
           RepID=HIS3_MYCBP
          Length = 115

 Score = 92.4 bits (228), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 40/92 (43%), Positives = 60/92 (65%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             DGL+  +VQ   SG+VLM+ +MN EAL +TL++ + T++SR++   W KG TSG+  +
Sbjct: 14  NADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQH 73

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           V S+  DCD D +L+  + +G  CH G  SCF
Sbjct: 74  VHSVRLDCDGDAVLLTVDQVGGACHTGDHSCF 105


>UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria
           RepID=HIS3_CORJK
          Length = 127

 Score = 91.7 bits (226), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 42/90 (46%), Positives = 57/90 (63%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P IVQ   +G+VLM+ +MN  AL  TL + K T++SR++Q  W KGETSG+   V 
Sbjct: 32  DGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIKGETSGHTQRVE 91

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            +  DCD DT+L+     G  CH G  +CF
Sbjct: 92  EVRLDCDGDTVLLKIEQTGAACHTGNRTCF 121


>UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria
           RepID=HIS3_BURS3
          Length = 138

 Score = 91.3 bits (225), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 41/91 (45%), Positives = 60/91 (65%), Gaps = 1/91 (1%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+PVI Q A + +VLM  +MN EAL KT+E+ +  ++SR+++RLW KGE SG+  +V 
Sbjct: 20  NGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGEESGHVQHVH 79

Query: 76  SIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105
            +  DCD D +L+    + G  CH G  SCF
Sbjct: 80  EVRLDCDEDVVLLKVEQVSGIACHTGRHSCF 110


>UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria
           RepID=HIS3_RHOPT
          Length = 151

 Score = 91.3 bits (225), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 39/90 (43%), Positives = 61/90 (67%), Gaps = 1/90 (1%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+ V+   A +G+VLM+ +MN EALD+T+++G+  ++SR+++RLW KGETSG+   V+ 
Sbjct: 31  GLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGHIQKVLE 90

Query: 77  IAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105
           +  DCD D + +  +   G  CH G  SCF
Sbjct: 91  MRVDCDQDAVWIKVDQTGGAACHTGRHSCF 120


>UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R0U5_9PLAN
          Length = 310

 Score = 90.9 bits (224), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 37/88 (42%), Positives = 58/88 (65%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P I Q   +GEVLM+ +MN E+  +T+ +G+  ++SR++ +LW KGE SG+   V  +
Sbjct: 181 LLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESGHMQTVHGV 240

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF 105
             DCD DT+L+  + +G  CH+G  SCF
Sbjct: 241 YVDCDADTILLKVSQVGAACHEGFRSCF 268


>UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_MESSB
          Length = 139

 Score = 90.9 bits (224), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 45/92 (48%), Positives = 59/92 (64%), Gaps = 2/92 (2%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+  +V  A  G +LM+ +MN EAL KTLE+G   ++SR++  LW KGETSGN  +V 
Sbjct: 31  NGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGNLQHVE 90

Query: 76  SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105
           SI+ DCD D +L  V     G TCH G  SCF
Sbjct: 91  SISTDCDQDAVLLKVRVGGEGATCHTGRRSCF 122


>UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium
           amycolatum SK46 RepID=UPI000185C2AA
          Length = 132

 Score = 90.9 bits (224), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 41/90 (45%), Positives = 58/90 (64%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P IVQ   +G VLM+ +M+  AL  T+ + + T++SR++   W KG TSG+F  V 
Sbjct: 35  DGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWIKGLTSGHFQTVT 94

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           S+A DCD DT+L+     G  CH G+ SCF
Sbjct: 95  SLALDCDGDTVLMQVVQDGAACHTGSHSCF 124


>UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria
           RepID=B9QYY7_9RHOB
          Length = 159

 Score = 90.1 bits (222), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 43/92 (46%), Positives = 57/92 (61%), Gaps = 2/92 (2%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+  +V    + EVLM+GYMN EAL +T+E+G+  ++SR+++  W KGETSG    V 
Sbjct: 36  DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQIQKVQ 95

Query: 76  SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105
            I  DCD D L+  V     G TCH G  SCF
Sbjct: 96  EILTDCDQDALVVKVTVEGNGATCHVGYRSCF 127


>UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC
           49814 RepID=C6XNB8_HIRBI
          Length = 139

 Score = 89.7 bits (221), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 41/92 (44%), Positives = 57/92 (61%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+  I Q   S EVLML +MN +AL  T+E+G+  ++SR++ +LW KG+TSG +  
Sbjct: 30  NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           V SI  DCD D +L+        CH G  SCF
Sbjct: 90  VESIHTDCDQDAILLKVRQTDGACHTGRVSCF 121


>UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis
           RepID=HIS2_ZYMMO
          Length = 107

 Score = 89.7 bits (221), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 43/87 (49%), Positives = 57/87 (65%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L  +E ++AER+ A PE SY + L+  GT  IAQKVGEE VET +AA   D+  L +EA+
Sbjct: 6   LAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSLESEAA 65

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL++HL VLL D+G     V   LR+R
Sbjct: 66  DLIFHLAVLLADRGSSFENVFSELRRR 92


>UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA
          Length = 126

 Score = 89.4 bits (220), Expect = 8e-17,   Method: Compositional matrix adjust.
 Identities = 40/88 (45%), Positives = 55/88 (62%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P I Q A +G VLML +MN EA D+T+   +  +FSR++ +LW KG+TSG+   V  I
Sbjct: 21  LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF 105
             DCD DT+L+     G  CH+   SCF
Sbjct: 81  RVDCDADTILLSVEQTGAACHENYESCF 108


>UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae
           RepID=HIS3_ZYMMO
          Length = 124

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 35/89 (39%), Positives = 59/89 (66%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  ++  A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ + +  
Sbjct: 19  GLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHVMKIQE 78

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           I  DCD DTL +   P+GP CH G  SCF
Sbjct: 79  IRIDCDQDTLWLKVIPMGPACHTGAQSCF 107


>UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KWI3_HALNC
          Length = 124

 Score = 88.2 bits (217), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 43/88 (48%), Positives = 58/88 (65%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L QL  ++ +RK ADP +SY A+L+A G  +IAQKVGEEGVE ALAA   D   + +E 
Sbjct: 9   LLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDNVAIVSEM 68

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL +H +VLL D GL    V++ L +R
Sbjct: 69  ADLWFHSMVLLADAGLSHQAVLDELGER 96


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score = 87.8 bits (216), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 64/187 (34%), Positives = 100/187 (53%), Gaps = 11/187 (5%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           ++ DGL   +V     G  L L Y + E++ ++L +G+  + SR K+ LW KGE+SG+  
Sbjct: 202 DRPDGLYTTLVTDE-RGVALGLVYSSEESVAESLRTGRGVYQSR-KRGLWYKGESSGDIQ 259

Query: 73  NVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131
            +VS++ DCD+D L  +    G   CH  T +CFGD    +  L +L++ L  RK + P+
Sbjct: 260 ELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQKTLQSRKESAPQ 315

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            SYTA+L+ +  + +  K+ EE  E   A T   +  +  EA+DL Y  L      G+ L
Sbjct: 316 GSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFALTKCVAAGVSL 371

Query: 192 TTVIENL 198
             V  NL
Sbjct: 372 EDVERNL 378


>UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae
           RepID=HIS3_PYRCJ
          Length = 128

 Score = 87.4 bits (215), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 39/102 (38%), Positives = 61/102 (59%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
           + L++    G +  +VQ   +GEVLM+G+M+P A+  TL +G   ++S +++R+W KGET
Sbjct: 17  KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
           SG++  V     DCD D +++    IG  CH G  SCF   A
Sbjct: 77  SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSPA 118


>UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R0N1_9RHOB
          Length = 156

 Score = 87.0 bits (214), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 42/92 (45%), Positives = 57/92 (61%), Gaps = 2/92 (2%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+   V    SGE+LM+GYMN E+L +T+E+G+  ++SR++Q  W KG TSG    V+
Sbjct: 32  NGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEYWKKGGTSGQVQEVI 91

Query: 76  SIAPDCDNDT--LLVLANPIGPTCHKGTSSCF 105
            I  DCD D   L V  +  G TCH G  SCF
Sbjct: 92  EIRTDCDQDAIWLRVKVHGNGATCHVGYRSCF 123


>UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_RALEJ
          Length = 135

 Score = 86.7 bits (213), Expect = 4e-16,   Method: Compositional matrix adjust.
 Identities = 52/129 (40%), Positives = 71/129 (55%), Gaps = 15/129 (11%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+PVIVQ   + +VLM  +MN +AL KT E G+  F+SR+++RLW KGE SG+   V 
Sbjct: 14  NGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRLWHKGEESGHVQKVH 73

Query: 76  SIAPDCDNDTLLVLANPI-GPTCHKGTSSCF-----GDT-AHQWLFLYQLEQLLAERKSA 128
            +  DCD D +L+    +    CH G  SCF     GD  +  W     +E +L      
Sbjct: 74  EMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEGDAESGDW---QTVEPVL-----K 125

Query: 129 DPETSYTAK 137
           DP   YTAK
Sbjct: 126 DPSQIYTAK 134


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score = 86.3 bits (212), Expect = 5e-16,   Method: Compositional matrix adjust.
 Identities = 66/188 (35%), Positives = 98/188 (52%), Gaps = 14/188 (7%)

Query: 13  EKTDGLMPVIV--QHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           ++ DGL+P +V  +H  +   L L Y + E++ + L++    + SR K+ LW KG TSG+
Sbjct: 204 DRADGLIPTVVVDEHDTA---LGLVYSSEESVGEALKTQTGVYQSR-KRGLWYKGATSGD 259

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              +V I+ DCDND L  +    G  CH   S CFGD       L +LE  L  RK + P
Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDLKG----LAKLESTLLSRKQSAP 315

Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190
             SYTA+L+ S  K +  K+ EE  E   A T  +   +  EA+DL+Y  L      G+ 
Sbjct: 316 AGSYTARLF-SDEKLLRAKIMEEAEELCDANTPEN---VAFEAADLIYFALTKAVGAGVT 371

Query: 191 LTTVIENL 198
           L  + ++L
Sbjct: 372 LADIEKSL 379


>UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria
           RepID=C7RQA3_9PROT
          Length = 142

 Score = 86.3 bits (212), Expect = 6e-16,   Method: Compositional matrix adjust.
 Identities = 38/89 (42%), Positives = 57/89 (64%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  I Q   + E+LML +MN  A+++TL +G   ++SR+++ +W KGETSG    V+ 
Sbjct: 29  GLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRKGETSGCRQRVIE 88

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
              DCD D +L+L + +G  CH G SSCF
Sbjct: 89  TRFDCDGDAILLLVDQLGGACHTGRSSCF 117


>UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter
           necessarius RepID=B1XSV4_POLNS
          Length = 140

 Score = 85.9 bits (211), Expect = 7e-16,   Method: Compositional matrix adjust.
 Identities = 41/90 (45%), Positives = 58/90 (64%), Gaps = 1/90 (1%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PVI Q   S ++LM+ +MN +AL +TL  G+  +++R++Q+LW KGE SG+   V  
Sbjct: 32  GLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHKGEESGHTQKVKE 91

Query: 77  IAPDCDNDTLLVLA-NPIGPTCHKGTSSCF 105
           I  DCD DT+L+L     G  CH G  SCF
Sbjct: 92  IHLDCDGDTILLLVEQKDGIACHTGEHSCF 121


>UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae
           RepID=HIS3_GLUOX
          Length = 156

 Score = 85.9 bits (211), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 40/91 (43%), Positives = 59/91 (64%), Gaps = 1/91 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GL+  + Q A  G VLML +MN +AL +TL +G+V ++SR++Q+LW KGETSG    +
Sbjct: 42  ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKLWRKGETSGQQQKL 100

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +    DCD D +L++ +  G  CH G  SCF
Sbjct: 101 IEARLDCDMDAVLMIVDQTGVACHTGRRSCF 131


>UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris
           BL2 RepID=B8EQR3_METSB
          Length = 141

 Score = 85.9 bits (211), Expect = 8e-16,   Method: Compositional matrix adjust.
 Identities = 42/92 (45%), Positives = 55/92 (59%), Gaps = 2/92 (2%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+  + + A  GE+LM+ YMN EAL  TL +G+  ++SR++Q +W KG TSG    V 
Sbjct: 31  DGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKVR 90

Query: 76  SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105
            I  DCD D LL  + A   G  CH G  SCF
Sbjct: 91  EIRADCDQDALLLTIEAGGDGGACHTGRRSCF 122


>UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces
           RepID=HIS2_SCHPO
          Length = 417

 Score = 85.5 bits (210), Expect = 1e-15,   Method: Compositional matrix adjust.
 Identities = 64/192 (33%), Positives = 100/192 (52%), Gaps = 11/192 (5%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           ++ DGL   +V + + G  L L Y + E++ ++L++G   + SR K+ LW KG +SG   
Sbjct: 206 DREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSR-KRGLWYKGASSGAVQ 263

Query: 73  NVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131
           +++ I  DCD D L  +    G   CH  T  CFG  +     L QLE+ L +RK+  PE
Sbjct: 264 HLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASG----LCQLEKTLIDRKNNAPE 319

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            SYTA+L+ S  K +  K+ EE  E   A T  +   +  E +DLMY  +      G+ L
Sbjct: 320 GSYTARLF-SDPKLLRAKIMEEAEELCDATTKEN---VIWEMADLMYFAITRCVGSGVSL 375

Query: 192 TTVIENLRKRHQ 203
             +  +L  +H+
Sbjct: 376 NDISRHLDLKHR 387


>UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT
          Length = 116

 Score = 84.3 bits (207), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 39/89 (43%), Positives = 55/89 (61%), Gaps = 1/89 (1%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P I Q    G VLM+ +MN E++ KTL +G+  ++SR++ +LW KG TSG+   V  +
Sbjct: 18  LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKGATSGHIQKVKEL 77

Query: 78  APDCDNDTLLVLANPIGP-TCHKGTSSCF 105
             DCD DT+L+    IG   CH G  SCF
Sbjct: 78  FYDCDGDTILLKVEQIGDIACHTGARSCF 106


>UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41B27
          Length = 137

 Score = 84.0 bits (206), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 34/88 (38%), Positives = 57/88 (64%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+  + Q   + +VLM+ +MN EA+++TL++ K  ++S ++Q+ W KGE+SGN   V  +
Sbjct: 14  LVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKGESSGNVQTVKEM 73

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF 105
             DCD D +++  + IG  CH+G  SCF
Sbjct: 74  YIDCDADAIIMKVDQIGAACHEGYRSCF 101


>UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/
           phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus
           Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT
          Length = 127

 Score = 84.0 bits (206), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 43/119 (36%), Positives = 66/119 (55%), Gaps = 6/119 (5%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P ++  A  G+ L L YMN +A+ KT+E+GK+  F R++ RL  KGETSG+  +V  
Sbjct: 13  GLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLKGETSGHIQSVKR 72

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL-LAERKSADPETSY 134
           I  DC+ ++L+ +       CH G  SC+        ++ Q   + + E K  DPE  Y
Sbjct: 73  IYFDCEGNSLVFMVEQHVAACHAGYKSCYYRE-----YIPQTNSIQVVEEKVFDPENVY 126


>UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_PSEU2
          Length = 130

 Score = 83.6 bits (205), Expect = 4e-15,   Method: Compositional matrix adjust.
 Identities = 39/98 (39%), Positives = 58/98 (59%), Gaps = 2/98 (2%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           E+ W  +DGL+P I Q   +G VLM+ +MN EAL  T    +  ++SR++ +LW KGE S
Sbjct: 7   EIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGEES 65

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105
           G+   +  +  DCD D ++++   IG   CH G  SCF
Sbjct: 66  GHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCF 103


>UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_METTH
          Length = 138

 Score = 83.2 bits (204), Expect = 5e-15,   Method: Compositional matrix adjust.
 Identities = 37/88 (42%), Positives = 54/88 (61%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+  + Q   +GEVLM+ YMN EAL +TLE+G   ++S ++ +LW KGE+SG+   V  +
Sbjct: 23  LIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQRVKDV 82

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF 105
             DCD D +++     G  CH G  SCF
Sbjct: 83  LVDCDGDAVVLKVEQEGGACHTGYRSCF 110


>UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira
           pseudonana RepID=B8BUA9_THAPS
          Length = 272

 Score = 82.8 bits (203), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 59/193 (30%), Positives = 95/193 (49%), Gaps = 13/193 (6%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           ++ DGL   +V    SGE L L Y + E++   L+SG+  ++SR++  LW KG+TSG+F 
Sbjct: 62  DRGDGLYTTVVS-TRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSGHFQ 120

Query: 73  NVVSIAPDCDNDTLLVL----ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
            +  +  DCD D L        + I   CH  T +C+G+       L  LE  L +R   
Sbjct: 121 TLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEPRG----LRHLEGTLQQRLKD 176

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
            P  SYT +L+      +  K+ EE  E + A T   +  +  E +D++Y  +V     G
Sbjct: 177 APVGSYTKRLFEDEI-LLRDKLVEEAQELSEADT---KQHVAEELADVLYFAMVRAAKAG 232

Query: 189 LDLTTVIENLRKR 201
           + +   +E L +R
Sbjct: 233 VSIDDAVEELDRR 245


>UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales
           RepID=HIS3_RHISN
          Length = 152

 Score = 82.0 bits (201), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 40/91 (43%), Positives = 54/91 (59%), Gaps = 2/91 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  +V  A  GE+LM+ +MN EAL  T+E+G   ++SR++  LW KGE+SGN   V  
Sbjct: 29  GLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGNTQAVQE 88

Query: 77  IAPDCDNDTLLVLANPIG--PTCHKGTSSCF 105
           I  DCD D + +     G   TCH G  SCF
Sbjct: 89  IRTDCDQDAIWLKVTVAGHDATCHTGRRSCF 119


>UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI
          Length = 161

 Score = 82.0 bits (201), Expect = 1e-14,   Method: Compositional matrix adjust.
 Identities = 43/92 (46%), Positives = 59/92 (64%), Gaps = 2/92 (2%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+PV+   A +GEVLM  YMN EAL KT+E+G+  ++SR++Q+LW KG++SG    V 
Sbjct: 27  NGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGLVQKVQ 86

Query: 76  SIAPDCDNDTLL--VLANPIGPTCHKGTSSCF 105
            +A D D D L   V     G +CH G  SCF
Sbjct: 87  QLAIDDDQDCLWMQVEVAGSGASCHVGYRSCF 118


>UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria
           RepID=HIS2_MAGSA
          Length = 109

 Score = 81.3 bits (199), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 42/88 (47%), Positives = 56/88 (63%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L  ++A RK  DP+ SYTAKL+A G  +IAQK GEE VET +AA    + EL  E+
Sbjct: 7   ILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDELVGES 66

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +D +YHLLVL  D G++   V   L +R
Sbjct: 67  ADTLYHLLVLWADCGVEPAKVWAELARR 94


>UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN
          Length = 477

 Score = 80.9 bits (198), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 64/193 (33%), Positives = 95/193 (49%), Gaps = 10/193 (5%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           L  ++ D L   +V    +G  L L Y + E++   + SG+  ++SR++  LW KGE+SG
Sbjct: 249 LRTDRPDSLFTTVVADE-AGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKKGESSG 307

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           N   ++ I  DCD+D L    N  G   CH  T +C+G        L  LE +L  R   
Sbjct: 308 NAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHDGG----LRALESMLFSRHEN 363

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
            P  SYT +L+    + +  K+ EE  E A A +V D   +  EA+D+MY  +V     G
Sbjct: 364 APAESYTKRLF-DDAELLRNKLVEEAQELAEAESVPD---VAGEAADVMYFAMVRCVAAG 419

Query: 189 LDLTTVIENLRKR 201
             L+ V   L KR
Sbjct: 420 CKLSDVERMLDKR 432


>UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58
           RepID=Q1NG03_9SPHN
          Length = 157

 Score = 79.7 bits (195), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 42/92 (45%), Positives = 56/92 (60%), Gaps = 1/92 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GLMP IV +A    VLMLGYMN EAL +TL + +  F+SR+++ LW KGE SG    V
Sbjct: 25  AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGFRQRV 84

Query: 75  VSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF 105
             +  D D D L+++     P +CH G  SCF
Sbjct: 85  DHVLVDDDQDALILMVTIDAPGSCHVGFRSCF 116


>UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BVA1_9PROT
          Length = 104

 Score = 79.7 bits (195), Expect = 6e-14,   Method: Compositional matrix adjust.
 Identities = 36/87 (41%), Positives = 59/87 (67%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L +L+QL+  +K +DP  SYTAKL++ G + I +K GEE +E  +A+   ++  + NE++
Sbjct: 4   LDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVINESA 63

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D++YHLLVLL ++ + L  VI  L +R
Sbjct: 64  DVLYHLLVLLSEKSVTLKEVISELERR 90


>UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae
           RepID=HIS3_SULSO
          Length = 85

 Score = 78.6 bits (192), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 35/73 (47%), Positives = 47/73 (64%)

Query: 33  MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92
           M+G MN EAL KTL +G + F+S ++++LW KGETSGNF  +     DCD D +L     
Sbjct: 1   MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60

Query: 93  IGPTCHKGTSSCF 105
           +GP CH G  +CF
Sbjct: 61  LGPICHTGNYTCF 73


>UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira
           RepID=B5VZW9_SPIMA
          Length = 200

 Score = 77.8 bits (190), Expect = 2e-13,   Method: Compositional matrix adjust.
 Identities = 58/195 (29%), Positives = 89/195 (45%), Gaps = 32/195 (16%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW--------TKGETS 68
           GL+ + +Q  ++G VL LG MN EAL KTL + ++ +  +++  LW           +  
Sbjct: 30  GLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHPDIILESISYDYR 89

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           GNFL V  +A                  C    +   G T      L  L +++ +R+  
Sbjct: 90  GNFL-VAGVA-----------------YCPSELNGSGGHT------LAGLFRVICDRRDH 125

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
               SYT +L+A G  +I +K+GEE  E  +A    +   + +E +DL YH LV L    
Sbjct: 126 PNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAYHQ 185

Query: 189 LDLTTVIENLRKRHQ 203
           +DL  V E L  R Q
Sbjct: 186 VDLRKVYEQLEARRQ 200


>UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae
           RepID=HIS3_METS3
          Length = 132

 Score = 77.0 bits (188), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 37/99 (37%), Positives = 59/99 (59%), Gaps = 3/99 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
           R E++ +K   ++  I Q   +G++LM+  MN +AL KT+E+GK  ++S ++   W KGE
Sbjct: 6   RHEINGQK---VITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLKGE 62

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +SG+   V  I  DCD D +++     G  CH+G  SCF
Sbjct: 63  SSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCF 101


>UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria
           RepID=HIS2_BRUA1
          Length = 107

 Score = 77.0 bits (188), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 40/87 (45%), Positives = 57/87 (65%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L  LE+++AER S    TSYTA L A G  + AQK+GEE VET +AA   DR  + +E++
Sbjct: 6   LADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVVSESA 65

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YHL V+    G+ L  V++ L++R
Sbjct: 66  DLLYHLAVVWNIAGVALEDVLQELQRR 92


>UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001744401
          Length = 141

 Score = 75.5 bits (184), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 35/92 (38%), Positives = 52/92 (56%), Gaps = 1/92 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I     + E LM+ YMN E L  T+  G+  ++SR+++ +W KG+TSG F  V
Sbjct: 31  ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGEFQVV 90

Query: 75  VSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF 105
             I  DCD D +++    + G  CH    +CF
Sbjct: 91  KEIRVDCDQDAVILKVEQLGGGCCHTKAPTCF 122


>UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HIS3_IGNH4
          Length = 129

 Score = 74.3 bits (181), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 38/97 (39%), Positives = 57/97 (58%), Gaps = 1/97 (1%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           L++   D  +  + Q   SG+VLM+  MN EA+ KTL +G V ++S++++ LW KG TSG
Sbjct: 16  LNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGATSG 75

Query: 70  NFLNVVSIAPDCDNDT-LLVLANPIGPTCHKGTSSCF 105
           +   +     DCD D+ LLV+       CH+G  SCF
Sbjct: 76  HVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCF 112


>UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales
           RepID=HIS3_METVS
          Length = 136

 Score = 73.6 bits (179), Expect = 4e-12,   Method: Compositional matrix adjust.
 Identities = 31/75 (41%), Positives = 46/75 (61%)

Query: 31  VLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLA 90
           VLM  +M+ E+L  TL++G + +FS ++ ++W KGE S N   V+ +  DCD D LL + 
Sbjct: 43  VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWMKGEESKNVQKVLEVFKDCDGDALLFIV 102

Query: 91  NPIGPTCHKGTSSCF 105
              G  CH+G  SCF
Sbjct: 103 EQTGWACHEGYMSCF 117


>UniRef50_A0YJX3 Phosphoribosyl-ATP
           pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase
           n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN
          Length = 198

 Score = 73.2 bits (178), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 53/187 (28%), Positives = 87/187 (46%), Gaps = 12/187 (6%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I+Q  + G VL L +M+ ++L KT E  +V     +   L +    +G   +   
Sbjct: 24  GLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLLITGWRYD--- 80

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTA 136
             P C +  +LV    I    ++     F   +     L ++ +++ +R+    E SYT 
Sbjct: 81  --PACQSLLILVECGSIAEPQNE-----FAQVSSN--LLSEVFEVICDRRDHPQEDSYTC 131

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           KL A G  +I +K+GEE  E  +A    D   + +E +DL YH LV +     DL  V  
Sbjct: 132 KLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAYHRADLRQVYR 191

Query: 197 NLRKRHQ 203
            L +R +
Sbjct: 192 KLAERRR 198


>UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum
           ATCC 11170 RepID=HIS2_RHORT
          Length = 117

 Score = 73.2 bits (178), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 36/84 (42%), Positives = 51/84 (60%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L  ++A R+ ADP TSYTAKL+  G  +I QK GEE  E  +AA V    ++  E++D++
Sbjct: 20  LAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAESADVL 79

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YHL+VL  D G+    V   L +R
Sbjct: 80  YHLMVLWADVGVTPDRVWAELARR 103


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score = 72.8 bits (177), Expect = 8e-12,   Method: Compositional matrix adjust.
 Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 13/200 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           L  ++TDGL    V  +     L L Y +P ++ K++ +G   + SR +  LW KGE+SG
Sbjct: 201 LTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-LWHKGESSG 259

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPT-----CH-KGTSSCFGDTAHQWLFLYQLEQLLA 123
               VVSI  DCD+D +         T     CH +    CF         L +LE  L 
Sbjct: 260 ATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSATG----LAKLEATLK 315

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R    P  SYTA+L+ +    +  K+ EE  E A  A  +D+  +  EA+DL+Y  L  
Sbjct: 316 HRLQTAPAGSYTARLF-NDASLLGAKLREEAAELA-DANNNDKKHVAFEAADLIYFALTK 373

Query: 184 LQDQGLDLTTVIENLRKRHQ 203
               G+ L  +  +L  + +
Sbjct: 374 CVSAGIGLEEIEASLDAKAK 393


>UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales
           RepID=B0MMD1_9FIRM
          Length = 114

 Score = 72.4 bits (176), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 35/74 (47%), Positives = 49/74 (66%)

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT  L+  G  +I +KVGEE  ET +AA   D  EL NE +DL+YH++VL  D+GL
Sbjct: 26  PEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNADNDELKNEINDLLYHVMVLCADRGL 85

Query: 190 DLTTVIENLRKRHQ 203
           + + V E L +R++
Sbjct: 86  EWSEVEEVLSERNE 99


>UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis
           RepID=HIS2_SPHAL
          Length = 109

 Score = 70.9 bits (172), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 42/102 (41%), Positives = 59/102 (57%), Gaps = 7/102 (6%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
           S   G+T      L +LE ++ +R +A + E SY A L A G  +IAQK+GEE VE  +A
Sbjct: 2   SKAMGET------LGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIA 55

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A   D   L  EASDL++HL +LL ++GL    +   L +RH
Sbjct: 56  AVSEDDPALIGEASDLVFHLSILLAERGLTWDAIAAELDRRH 97


>UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD
          Length = 101

 Score = 70.9 bits (172), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 37/97 (38%), Positives = 54/97 (55%), Gaps = 6/97 (6%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           E +  L+PV+V    SG++LML Y +   L+ T  +G   ++SR++Q +W KG +SG   
Sbjct: 2   ETSTKLLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQ 61

Query: 73  NVVSIAPDCDNDTL----LVLANPIGPTCHKGTSSCF 105
            V ++  DCD D L    LVL +  G  CH    SCF
Sbjct: 62  LVQAVYRDCDGDALNFRVLVLGD--GRVCHTRQVSCF 96


>UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales
           RepID=HIS2_MESSB
          Length = 112

 Score = 70.1 bits (170), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 36/87 (41%), Positives = 57/87 (65%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L +LE ++AER ++    S+TA+L ++G  + A+K+GEE VET +AA   D+  L  E++
Sbjct: 6   LSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKALIAESA 65

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV+L+  G+ L  V+  L  R
Sbjct: 66  DLVYHWLVVLKIAGVRLDEVMLELESR 92


>UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria
           RepID=HIS2_GRABC
          Length = 160

 Score = 68.2 bits (165), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 37/96 (38%), Positives = 57/96 (59%), Gaps = 2/96 (2%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           D A Q   L +L +++ +R+ ADP  S++A+L + G  ++AQK GEE VE  + A   D+
Sbjct: 40  DNAVQ--VLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLVL    G++   V   L KR 
Sbjct: 98  EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133


>UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria
           RepID=HIS2_NITMU
          Length = 121

 Score = 67.0 bits (162), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 34/88 (38%), Positives = 49/88 (55%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L++L + +  RK +DP  SY AKL   G  +I +K+ EE  E  LA+   D   +  E 
Sbjct: 6   ILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVVRET 65

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL +H LVLL    L L  V++ LR+R
Sbjct: 66  ADLWFHCLVLLAHHNLKLGDVLDELRRR 93


>UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ
          Length = 127

 Score = 65.9 bits (159), Expect = 7e-10,   Method: Compositional matrix adjust.
 Identities = 37/87 (42%), Positives = 52/87 (59%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L +L  L+  R+S   + SYTA+L  +G +R A+K GEE VET +AA   D   L  EA+
Sbjct: 24  LTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSDASALRAEAA 83

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D +YHLLVLL+ + +    V+  L  R
Sbjct: 84  DTLYHLLVLLESRHVAFDDVLRVLEGR 110


>UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria
           RepID=HIS2_NITWN
          Length = 116

 Score = 65.1 bits (157), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 36/91 (39%), Positives = 51/91 (56%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           Q   ++ L  ++  R ++  + SYT KL   G    A+K+GEE VET +AA   DR  L 
Sbjct: 11  QRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKDRHHLI 70

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +DLM+H LVLL+  G+ L  V   L +R
Sbjct: 71  AEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101


>UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae
           RepID=Q2CDY7_9RHOB
          Length = 106

 Score = 64.7 bits (156), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 1/89 (1%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + L  L + +A RK ADP+ S+TA+L AS  +  A+K GEE VE  + A   DR  L +E
Sbjct: 1   MSLAALAETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           A+D++YHLLV+     + L  +   L +R
Sbjct: 60  AADVIYHLLVMCAVNDITLADIERELERR 88


>UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis
           HTCC2503 RepID=A3VQS9_9PROT
          Length = 109

 Score = 64.3 bits (155), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 36/77 (46%), Positives = 44/77 (57%)

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           RK AD   SYTA L   G  R A+K GEE VE ALA  +  R +L  E +D++YHL VLL
Sbjct: 18  RKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAETADVLYHLAVLL 77

Query: 185 QDQGLDLTTVIENLRKR 201
               LD + +   L KR
Sbjct: 78  AANELDWSDISAALTKR 94


>UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei
           RepID=HIS2_IGNH4
          Length = 102

 Score = 64.3 bits (155), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 34/90 (37%), Positives = 54/90 (60%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
           FL +L  ++ +R    P+ SYTA++   G    A+K GEE VE  +A+    R  +  EA
Sbjct: 4   FLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYEA 63

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +D++YHL+VLL  +G+D   VI+ L +R +
Sbjct: 64  ADVIYHLMVLLALRGVDWAEVIKELERRSR 93


>UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms
           RepID=HIS2_ALHEH
          Length = 109

 Score = 64.3 bits (155), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 38/90 (42%), Positives = 52/90 (57%), Gaps = 4/90 (4%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L  L ++L ER+ ADP TSY AKL+  G   I +KVGEE  E  +AA   DR ++  E 
Sbjct: 7   ILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVIYET 66

Query: 174 SDLMYHLLVLLQ--DQGLDLTTVIENLRKR 201
           +DL +H L++L   D G D   V+  L +R
Sbjct: 67  ADLWFHSLIMLSACDAGPD--DVLAELERR 94


>UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp.
          HTCC2601 RepID=Q0FX88_9RHOB
          Length = 164

 Score = 64.3 bits (155), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 30/60 (50%), Positives = 39/60 (65%)

Query: 16 DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
          DGLMP     A SGE+LMLG+M  EA   T+E+G+  +FSR +Q LW +G  SG  L +V
Sbjct: 13 DGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKLV 72


>UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZNB1_9GAMM
          Length = 125

 Score = 63.9 bits (154), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 33/88 (37%), Positives = 52/88 (59%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L  L +++ +R+ ADPE SY AKL+A G   + +K+GEE  ET +A    D   L +E 
Sbjct: 14  LLSALAEVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKNDDSDALVSEM 73

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL +H L++L  +G     V++ L +R
Sbjct: 74  ADLWFHSLIVLAARGRHPDDVLDELARR 101


>UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria
           RepID=HIS2_ACICJ
          Length = 133

 Score = 63.5 bits (153), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 33/88 (37%), Positives = 52/88 (59%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L   +  RK+ADP  S++A+L + G  ++AQK GEE VE  + A   +R  L  E+
Sbjct: 21  VLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNRTALIAES 80

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +D++YHLLV+    G+    V   L++R
Sbjct: 81  ADVLYHLLVMWVAAGVRPEDVWLELQRR 108


>UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria
           RepID=HIS2_CLOB1
          Length = 110

 Score = 61.6 bits (148), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 31/83 (37%), Positives = 47/83 (56%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   D  EL  E  DL YH+
Sbjct: 13  IIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEELIKEICDLTYHI 72

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +VL+ ++ + L  + + L KR +
Sbjct: 73  MVLMVEKQIKLDDIEKELEKRRE 95


>UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria
           RepID=HIS2_MAGSM
          Length = 252

 Score = 61.6 bits (148), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 39/90 (43%), Positives = 52/90 (57%), Gaps = 2/90 (2%)

Query: 114 FLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH-DRFELTN 171
            L Q+ Q++ +RKSA DPE SY AKL+  G   I +KVGEE  E  LA      R E+ +
Sbjct: 12  ILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKGRAARNEVAH 71

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           EA+DL++H LV L    +  T V+  L  R
Sbjct: 72  EAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101


>UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms
           RepID=HIS2_PELTS
          Length = 98

 Score = 61.2 bits (147), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 34/90 (37%), Positives = 49/90 (54%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +  L +++ +R+   P+ SYTA L+  G  +I +K+GEE  E  +AA       L  E 
Sbjct: 6   IIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAALVGEM 65

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +DL+YHLLVLL   GL    V+  L  R Q
Sbjct: 66  ADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95


>UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae
           RepID=HIS2_NATPD
          Length = 101

 Score = 61.2 bits (147), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 37/89 (41%), Positives = 54/89 (60%), Gaps = 2/89 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           L +L +++  RK   P+ SYTA L+    G   + +K+GEE  E  LAA   D  EL +E
Sbjct: 12  LDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDDDDEELAHE 71

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           A+D++YHLLVLL  + ++L  +   LRKR
Sbjct: 72  AADIVYHLLVLLSMKDMELADLRAELRKR 100


>UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa
           serovar Patoc RepID=B0SHA6_LEPBA
          Length = 202

 Score = 61.2 bits (147), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 32/88 (36%), Positives = 48/88 (54%), Gaps = 1/88 (1%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L P + Q  ++G+ LML +   E+L   +ESG  T+FSR++   W KGE SG+F  +  I
Sbjct: 94  LSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQI 152

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF 105
               +   +  + + IG  CH G  SCF
Sbjct: 153 YVHSNPFFVKYITDQIGAACHTGYYSCF 180


>UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae
           RepID=HIS2_METBF
          Length = 104

 Score = 61.2 bits (147), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 33/92 (35%), Positives = 53/92 (57%), Gaps = 2/92 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKL--YASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
            L ++ +++ +RK    E SY  KL  +  G  +I +KVGEE +ET LA    +  E+ +
Sbjct: 8   ILNRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNENHEEIVS 67

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           E+SDL++HLLV+L    + L  +   L  RH+
Sbjct: 68  ESSDLIFHLLVMLAANNVTLDEIAAELSARHE 99


>UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM
           10642 RepID=C8SBH0_FERPL
          Length = 92

 Score = 60.8 bits (146), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 34/91 (37%), Positives = 53/91 (58%), Gaps = 2/91 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKL--YASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           L +L++++ ERK      SYTAKL  +  G  ++ +K GEE VE  LA    D+  +  E
Sbjct: 2   LEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVYE 61

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+DL+YH +VLL    + +  V + LR+R +
Sbjct: 62  AADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92


>UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD
          Length = 253

 Score = 60.8 bits (146), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 30/80 (37%), Positives = 50/80 (62%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ + +S +   S+T K+ A G  +I +KVGEE VE  LA    D   + +EA+D++YH+
Sbjct: 56  IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115

Query: 181 LVLLQDQGLDLTTVIENLRK 200
           L+LL   GL L T+ + +R+
Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135


>UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=A6LT24_CLOB8
          Length = 108

 Score = 60.1 bits (144), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 32/85 (37%), Positives = 47/85 (55%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + + +RK+   E SYT  L+  GT +I +KVGEE  E  ++   +++ E  NE  DL 
Sbjct: 8   LYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINEICDLT 67

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVL+    + +  V   L KR 
Sbjct: 68  YHLLVLMAQMNISIEEVGAELEKRR 92


>UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira
           RepID=HIS3_LEPIN
          Length = 187

 Score = 60.1 bits (144), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 9/104 (8%)

Query: 10  LDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LD++KT          L+PV+    + G++LM  + N E+   +L++G   +FSR++ +L
Sbjct: 61  LDFQKTTELLLTGKKNLVPVVAID-LQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQL 119

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           W KG+TSG+   ++ I    D   L+         CH+G  SCF
Sbjct: 120 WKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCF 163


>UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria
           RepID=HIS2_HALHL
          Length = 114

 Score = 59.7 bits (143), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 31/87 (35%), Positives = 50/87 (57%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L  L + + +R+ A  +TSY A+L+  G   I +KVGEE  E  +AA   +R ++  E +
Sbjct: 14  LRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYETA 73

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL +H LV+L   G+ +  V+  L +R
Sbjct: 74  DLWFHTLVMLSASGVSVDEVLAELERR 100


>UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing
           symbionts RepID=HIS2_VESOH
          Length = 105

 Score = 59.3 bits (142), Expect = 8e-08,   Method: Compositional matrix adjust.
 Identities = 31/88 (35%), Positives = 49/88 (55%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +LEQ+L +RKSA  + SY + LY  GT  I +K+ EE  E  +A       ++  E 
Sbjct: 4   ILIKLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEI 63

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL +H LVLL+ + + +  +   L +R
Sbjct: 64  ADLWFHTLVLLRFKKIKVEQITNELSRR 91


>UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota
           RepID=HIS2_META3
          Length = 96

 Score = 58.9 bits (141), Expect = 9e-08,   Method: Compositional matrix adjust.
 Identities = 31/74 (41%), Positives = 46/74 (62%), Gaps = 4/74 (5%)

Query: 120 QLLAERKSADPETSYTAKLYASGTK----RIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +R    PE SY A L  +  K    +I +KVGEE  ET LAA   D+ EL  E++D
Sbjct: 9   EIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESAD 68

Query: 176 LMYHLLVLLQDQGL 189
           L++H+LVLL + G+
Sbjct: 69  LIFHILVLLANNGI 82


>UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria
           RepID=HIS2_NEIG1
          Length = 107

 Score = 58.2 bits (139), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 32/88 (36%), Positives = 48/88 (54%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L  ++Q + +RKSADP  SY A+L   G  +I +KV EE  E  +A+   D   L  E 
Sbjct: 5   VLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHLVYEV 64

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL +H ++LL    L    V++ L +R
Sbjct: 65  ADLWFHTMILLTHHDLKAEDVLDELSRR 92


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score = 58.2 bits (139), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 8/119 (6%)

Query: 80  DCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLY 139
           DCDND +  +    G  CH     CFG+       + +LE+ L  RK + PE SYTA+L+
Sbjct: 173 DCDNDAIKFVVRQKGRFCHLEQDGCFGNLTG----IARLEKTLKARKESAPEGSYTARLF 228

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
            +  K +  K+ EE  E   A T  D   +  EA+DL+Y  L      G+ +  + ++L
Sbjct: 229 -NDEKLLRAKIMEEAEELCDAKTKED---VAFEAADLIYFALTKAVSAGVSVADIEKSL 283


>UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes
           RepID=HIS2_BACC2
          Length = 107

 Score = 58.2 bits (139), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 28/85 (32%), Positives = 49/85 (57%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + + ERK +    SYT  L++ G  +I +K+GEE  E  +A   +D+ E+  E  D+ 
Sbjct: 8   LYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVF 67

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YH  VLL ++ + L  V+  +++R+
Sbjct: 68  YHCFVLLAEKNIALEDVMREVKERN 92


>UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium
           RepID=HIS2_CLONN
          Length = 110

 Score = 57.8 bits (138), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 29/90 (32%), Positives = 51/90 (56%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   ++ +L  E 
Sbjct: 6   VIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDDLIAEV 65

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            D++YH++VL+ ++ + L  +   L KR +
Sbjct: 66  CDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95


>UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales
           RepID=Q0F926_9RHOB
          Length = 105

 Score = 57.4 bits (137), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 33/89 (37%), Positives = 56/89 (62%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L Q +  RK+   E SY ++L  SG+++ A+K GEE VE  +AA   D+  LT E+
Sbjct: 4   ILIRLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEES 63

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +D+++H+LV+L    +D  +V++ L +R 
Sbjct: 64  ADVLFHMLVMLSSCDVDFKSVLKELERRE 92


>UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales
           RepID=HIS2_LEUMM
          Length = 114

 Score = 56.2 bits (134), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 33/78 (42%), Positives = 45/78 (57%), Gaps = 1/78 (1%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ERK      SYT  LY  G  +I +KVGEE  E  L A  ++  EL  E SDL++HL+VL
Sbjct: 15  ERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNNE-ELIYETSDLLFHLMVL 73

Query: 184 LQDQGLDLTTVIENLRKR 201
           L ++G+ L  + + L  R
Sbjct: 74  LVEKGVSLDDIKDELGSR 91


>UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5
          Length = 105

 Score = 55.8 bits (133), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 29/87 (33%), Positives = 50/87 (57%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L  ++ +RK    + SYT  L+  G  +I +KVGEE  E  +A+   ++ +   E  DL
Sbjct: 4   ELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEICDL 63

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +YH+LVL+ ++ + L  + + L KR Q
Sbjct: 64  IYHVLVLMANENITLEELRKELEKRRQ 90


>UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SM22_9BACT
          Length = 100

 Score = 54.7 bits (130), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 28/88 (31%), Positives = 51/88 (57%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L +++ ERK+   + SYT +L   G+ +I +K+GEE  E   A    D  ++  E 
Sbjct: 5   IIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDVAGET 64

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL+YHL+V L+ + +    V+  L++R
Sbjct: 65  ADLLYHLIVALEFRNVQFEDVLGVLQER 92


>UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales
           RepID=HIS2_METB6
          Length = 104

 Score = 53.9 bits (128), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 32/91 (35%), Positives = 49/91 (53%), Gaps = 2/91 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + +L  ++ ER     E SYT++L     G  ++ +KVGEE  E  LA         T E
Sbjct: 14  IRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEESTEFILAVKNGVPERTTEE 73

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+DL +H+LV L+   +DL+ VI  L +R +
Sbjct: 74  AADLFFHVLVALRAADVDLSGVIRELERRRK 104


>UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TJZ9_9PROT
          Length = 104

 Score = 53.5 bits (127), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 29/78 (37%), Positives = 45/78 (57%)

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
           ++  P  S TA+L   G  +IA+KV EE  E AL A V DR  +  E++DL+Y+L+VL  
Sbjct: 16  RAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRESADLLYNLMVLWV 75

Query: 186 DQGLDLTTVIENLRKRHQ 203
             G+  + V   + +R +
Sbjct: 76  WMGITPSEVWAEMEQREK 93


>UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae
           RepID=HIS2_METS5
          Length = 93

 Score = 52.8 bits (125), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 38/90 (42%), Positives = 55/90 (61%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L  ++A+R    PE SYTA L   G   +A+KVGEE VE  +A+    R  + +E 
Sbjct: 4   VLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSET 63

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +DL+YHLLVLL  +G+ L  V + LR+R +
Sbjct: 64  ADLIYHLLVLLAMEGISLDEVRDELRRRMK 93


>UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria
           RepID=HIS2_BURCC
          Length = 121

 Score = 52.4 bits (124), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 31/91 (34%), Positives = 46/91 (50%), Gaps = 4/91 (4%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR----FELT 170
           L +L  ++  RK  DP+ SY ++L+  G   + +K+GEE  E  LAA    +      L 
Sbjct: 9   LLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQGGAPTALV 68

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +DL +H LV+L    L    VI  L +R
Sbjct: 69  GEVADLWFHCLVMLSHFDLSPADVIAELERR 99


>UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae
           RepID=Q0C645_HYPNA
          Length = 120

 Score = 51.6 bits (122), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 29/74 (39%), Positives = 40/74 (54%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           D  +S+TAKL A G    A KV EEG E A A        + +EA+D++YH+ V L+ +G
Sbjct: 32  DASSSWTAKLLAKGPDAAAAKVAEEGGELADAVRRESDDRVASEAADVIYHVFVALRSRG 91

Query: 189 LDLTTVIENLRKRH 202
           + L  V   L  R 
Sbjct: 92  VALDAVAGALEARQ 105


>UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=HIS2_UNCMA
          Length = 95

 Score = 51.2 bits (121), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 28/91 (30%), Positives = 48/91 (52%), Gaps = 2/91 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           L ++  ++A+RK    E SYT  LY    G  ++ +K+GEE  E  +AA      E+ +E
Sbjct: 5   LDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIVSE 64

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            +DL +H +VLL  + +    + E   +R +
Sbjct: 65  CADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95


>UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=A4EBZ9_9ACTN
          Length = 105

 Score = 51.2 bits (121), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 30/87 (34%), Positives = 46/87 (52%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L  L +++  R+ A P+ SYTA+L       + +K+ EE  E  +A   +D   +  EA 
Sbjct: 17  LTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIMACKDNDHDHIRYEAG 76

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YHLLV L+  G+ L  +   L  R
Sbjct: 77  DLVYHLLVTLERYGITLDELAGELNAR 103


>UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei
           group RepID=HIS2_LACCB
          Length = 110

 Score = 51.2 bits (121), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 29/85 (34%), Positives = 44/85 (51%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L   + ER++     SYT  L+  G  +I +KVGEE  E  +AA   D      E +DL 
Sbjct: 11  LYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPAFILEVADLT 70

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YH+LVL+ ++G+ +  +   L  R 
Sbjct: 71  YHVLVLMVERGITVDQIATELASRE 95


>UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium
           RepID=C4L178_EXISA
          Length = 102

 Score = 50.8 bits (120), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 39/89 (43%), Positives = 55/89 (61%), Gaps = 2/89 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +++LEQL+  RK    E SYT  L+  G ++IA+K GEE  E  +AA   +  +L  E+
Sbjct: 1   MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTDE--DLVEES 58

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL+YHLLVLL  +G+ L  V   L KRH
Sbjct: 59  ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87


>UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum
           hungatei JF-1 RepID=Q2FUB9_METHJ
          Length = 91

 Score = 50.4 bits (119), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 25/83 (30%), Positives = 49/83 (59%), Gaps = 2/83 (2%)

Query: 121 LLAERKSADPETSYTAKL--YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           ++ ER +   E SYT+K+  ++ G  +  +K+GEE  E  +A    D+  ++ E +DL++
Sbjct: 7   VIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEEGADLLF 66

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H ++ L+  G+ L +V + L+ R
Sbjct: 67  HFMLALKRSGVTLQSVWDELQSR 89


>UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales
           RepID=HIS2_BORA1
          Length = 116

 Score = 50.4 bits (119), Expect = 4e-05,   Method: Compositional matrix adjust.
 Identities = 28/74 (37%), Positives = 38/74 (51%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP+TSY AKL A G     +K+GEE  E  +AA       + +E +DL +H LV L    
Sbjct: 29  DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88

Query: 189 LDLTTVIENLRKRH 202
           L    V+  L +R 
Sbjct: 89  LRPEDVLAELARRE 102


>UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae
           RepID=HIS22_BRAJA
          Length = 134

 Score = 49.7 bits (117), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 25/74 (33%), Positives = 41/74 (55%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP TS TA+L+  G  ++A+K+ EE +E  + A   D   +  E++DL+Y+L VL    G
Sbjct: 19  DPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRESADLLYNLTVLWASAG 78

Query: 189 LDLTTVIENLRKRH 202
           +    V   + +R 
Sbjct: 79  VRPEDVWREMTRRE 92


>UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani
           RepID=HIS2_CLOTE
          Length = 107

 Score = 49.7 bits (117), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 29/88 (32%), Positives = 52/88 (59%), Gaps = 4/88 (4%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L +++ +RK+ D   SY   L+   + +I +K+GE+  E  +A     + E  +E 
Sbjct: 6   LIEELVEVIKDRKN-DIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEI 61

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           SDL+Y+L+VL+  Q +++  VIE L KR
Sbjct: 62  SDLIYNLMVLMMKQNIEIENVIEELGKR 89


>UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae
           RepID=A4SV22_POLSQ
          Length = 133

 Score = 49.7 bits (117), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%)

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAA--------TVHDRFELTNEASDLMY 178
           SADP+TSYTA L++ G   I +K+GEE  E  +AA            +  L  E +DL +
Sbjct: 33  SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L+ L    L    VI  L +R
Sbjct: 93  HCLIALSQFNLRPEDVIAELDRR 115


>UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria
           RepID=HIS2_ACIAC
          Length = 137

 Score = 47.4 bits (111), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 33/111 (29%), Positives = 48/111 (43%), Gaps = 7/111 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSA---DPETSYTAKLYASGTKRIAQKVGEEG 154
           H   S       H    L +L  ++  RK A   D + SY A+L   G     +K+GEE 
Sbjct: 3   HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62

Query: 155 VETALAAT----VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E  +AA       D  +L  E +DL +H ++ L   GL    V+  L +R
Sbjct: 63  TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERR 113


>UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria
           RepID=HIS2_METS4
          Length = 107

 Score = 47.0 bits (110), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 40/87 (45%), Positives = 59/87 (67%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L  L++++  R +A P+ SYTAKL A+G  + A+K+GEE VE A+AA   DR  L +EA+
Sbjct: 6   LADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGLVSEAA 65

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D++YHLLV+L   G+ L  V+  L +R
Sbjct: 66  DVLYHLLVVLVGSGVALEDVMAELERR 92


>UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB
          Length = 101

 Score = 45.8 bits (107), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 2/89 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L  L   + +RK+ D + SYT+ L + G  +   K+ EE  E  L   ++D+  + +EA+
Sbjct: 5   LLNLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDE--LKEALNDKSNIVHEAA 62

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           D +YH+LV L+   +    V++ L  R +
Sbjct: 63  DTIYHILVTLEAADIKFEDVLKELEGRKK 91


>UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K
           RepID=B4UDK1_ANASK
          Length = 110

 Score = 45.1 bits (105), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 36/95 (37%), Positives = 49/95 (51%), Gaps = 7/95 (7%)

Query: 114 FLYQLEQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVET-----ALAATVHDRF 167
           FL +L   +  R++ A P  SYT KL A+   RI +K+ EE  E      AL      + 
Sbjct: 6   FLAKLWATIESRRADAAPAESYTKKLLAAPA-RIRRKIIEEAYEVNEAHQALLDGKDTKD 64

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            L +EA+DL+YHL VLL    +  T V   L +RH
Sbjct: 65  HLAHEAADLLYHLYVLLASADVTPTEVYGVLERRH 99


>UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium
           HIMB114 RepID=D0RQN9_9RICK
          Length = 103

 Score = 44.7 bits (104), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 28/80 (35%), Positives = 47/80 (58%), Gaps = 3/80 (3%)

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + ERK++    SYT KL  + +    +KV EE  E  L   ++++    +EA+D+MYH+L
Sbjct: 12  IRERKNSSEHESYTKKLLDNNS-LCREKVMEEIKE--LVEALNEKKNEVHEAADVMYHIL 68

Query: 182 VLLQDQGLDLTTVIENLRKR 201
           VLL+   + +  V+  L+KR
Sbjct: 69  VLLEANNVKVEDVMNELKKR 88


>UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae
           RepID=HIS2_METS3
          Length = 96

 Score = 43.9 bits (102), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 30/94 (31%), Positives = 53/94 (56%), Gaps = 8/94 (8%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKR----IAQKVGEEGVETALAATVHDRFEL 169
            + ++ ++L ER+  +P  SYT+K+     K+    I +KV EE  E  LAA   +   L
Sbjct: 6   IIREVYKVLEERRD-NPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKNDEN--L 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENL-RKRH 202
             E+ DL++H L++L  +G+++  + E   R+RH
Sbjct: 63  VYESVDLIFHTLLILVYKGIEIDEIFEEFARRRH 96


>UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RQ70_FIBSS
          Length = 86

 Score = 42.7 bits (99), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 25/82 (30%), Positives = 42/82 (51%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           ++  L  +RK   PE   T +L+  G   I +K+ EE  E+ +AA    R     E S +
Sbjct: 5   EMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLELSQV 64

Query: 177 MYHLLVLLQDQGLDLTTVIENL 198
           +Y++ V++ ++GL L  V   L
Sbjct: 65  LYYVAVMMAEKGLTLEEVYAKL 86


>UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae
           RepID=HIS2_RHOBA
          Length = 120

 Score = 42.0 bits (97), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 35/92 (38%), Positives = 47/92 (51%), Gaps = 3/92 (3%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFEL 169
           L L +L   L  R +  PE SYT KL   G + I +K+ EE  E   AA   D   R   
Sbjct: 6   LPLDRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHA 65

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             EA DL+YH +VL+  +G++L  V   L +R
Sbjct: 66  IYEAGDLIYHAMVLMAWRGIELDEVAAELARR 97


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ...   283   3e-75
UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero...   280   3e-74
UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri...   277   2e-73
UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac...   276   2e-73
UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri...   276   4e-73
UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon...   270   1e-71
UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   270   2e-71
UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell...   270   3e-71
UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob...   269   3e-71
UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   268   1e-70
UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI...   267   1e-70
UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba...   266   3e-70
UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm...   265   5e-70
UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac...   265   8e-70
UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi...   264   1e-69
UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact...   262   7e-69
UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   261   9e-69
UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p...   261   1e-68
UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific...   258   9e-68
UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana...   257   2e-67
UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   256   3e-67
UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell...   255   7e-67
UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul...   255   8e-67
UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm...   253   2e-66
UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   252   6e-66
UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   252   7e-66
UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   252   7e-66
UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   251   1e-65
UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   250   2e-65
UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos...   250   2e-65
UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote...   247   1e-64
UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   247   1e-64
UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy...   246   4e-64
UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   245   6e-64
UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   245   6e-64
UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ...   245   9e-64
UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman...   244   1e-63
UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos...   242   4e-63
UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy...   241   9e-63
UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero...   241   1e-62
UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI...   241   1e-62
UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI...   240   2e-62
UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His...   240   3e-62
UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ...   239   4e-62
UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte...   238   1e-61
UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   236   4e-61
UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep...   235   1e-60
UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His...   233   3e-60
UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   233   4e-60
UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   231   1e-59
UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5     229   4e-59
UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   229   5e-59
UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   223   3e-57
UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A...   213   2e-54
UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper...   211   1e-53
UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI...   210   2e-53
UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel...   209   4e-53
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   206   4e-52
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   194   1e-48
UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T...   193   4e-48
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   192   6e-48
UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros...   188   1e-46
UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor...   186   3e-46
UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz...   186   3e-46
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   184   2e-45
UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon...   173   3e-42
UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu...   173   5e-42
UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   170   2e-41
UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   167   2e-40
UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter...   166   3e-40
UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul...   166   4e-40
UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu...   166   5e-40
UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax...   166   6e-40
UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin...   164   1e-39
UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar...   164   1e-39
UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo...   164   2e-39
UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote...   164   2e-39
UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m...   164   2e-39
UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin...   163   3e-39
UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap...   163   3e-39
UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   163   3e-39
UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte...   163   4e-39
UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   163   4e-39
UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   162   5e-39
UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell...   162   6e-39
UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   161   1e-38
UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote...   161   1e-38
UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote...   161   1e-38
UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   161   2e-38
UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin...   161   2e-38
UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch...   161   2e-38
UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap...   160   2e-38
UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   160   3e-38
UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   159   4e-38
UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein...   159   5e-38
UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte...   159   5e-38
UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   159   6e-38
UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm...   159   6e-38
UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte...   159   6e-38
UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte...   159   7e-38
UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   158   8e-38
UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   157   2e-37
UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact...   157   2e-37
UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob...   157   2e-37
UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax...   157   2e-37
UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   157   2e-37
UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon...   156   3e-37
UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero...   156   5e-37
UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan...   156   5e-37
UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote...   155   7e-37
UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte...   153   3e-36
UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote...   153   4e-36
UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu...   152   6e-36
UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob...   152   6e-36
UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin...   152   9e-36
UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein...   151   1e-35
UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob...   151   1e-35
UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   150   2e-35
UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo...   150   3e-35
UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero...   150   3e-35
UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   150   3e-35
UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p...   150   3e-35
UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom...   149   4e-35
UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob...   149   6e-35
UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro...   149   7e-35
UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo...   148   8e-35
UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=...   148   9e-35
UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ...   148   2e-34
UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu...   147   2e-34
UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr...   145   7e-34
UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl...   144   1e-33
UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   143   3e-33
UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr...   141   2e-32
UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax...   141   2e-32
UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo...   140   3e-32
UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo...   138   1e-31
UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros...   134   2e-30
UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico...   133   3e-30
UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing...   132   9e-30
UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha...   131   1e-29
UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos...   129   5e-29
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   129   7e-29
UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu...   128   9e-29
UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact...   126   4e-28
UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact...   126   7e-28
UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C...   124   1e-27
UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost...   124   2e-27
UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo...   124   2e-27
UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm...   123   3e-27
UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=...   123   3e-27
UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos...   123   3e-27
UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph...   121   1e-26
UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap...   121   1e-26
UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi...   120   2e-26
UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha...   120   2e-26
UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk...   120   3e-26
UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph...   120   4e-26
UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo...   119   5e-26
UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri...   118   1e-25
UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot...   118   1e-25
UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell...   118   1e-25
UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl...   118   1e-25
UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto...   118   1e-25
UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   118   2e-25
UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot...   117   2e-25
UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul...   117   3e-25
UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid...   116   5e-25
UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote...   116   6e-25
UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   115   8e-25
UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther...   115   9e-25
UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh...   114   2e-24
UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta...   114   2e-24
UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph...   114   2e-24
UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   114   2e-24
UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...   114   2e-24
UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot...   114   2e-24
UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto...   113   4e-24
UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra...   112   7e-24
UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom...   111   1e-23
UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph...   111   2e-23
UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob...   111   2e-23
UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo...   111   2e-23
UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi...   110   2e-23
UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu...   110   4e-23
UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   109   4e-23
UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins...   108   9e-23
UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha...   108   9e-23
UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...   107   2e-22
UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...   105   9e-22
UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin...   104   2e-21
UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br...   104   2e-21
UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...   104   2e-21
UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury...   102   8e-21
UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu...   102   1e-20
UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost...   100   3e-20
UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom...    96   4e-19
UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov...    95   1e-18
UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re...    95   2e-18
UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob...    91   2e-17
UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo...    91   2e-17
UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta...    91   3e-17
UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo...    90   4e-17
UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo...    85   1e-15
UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph...    72   1e-11

Sequences not found previously or not previously below threshold:

UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha...    87   4e-16
UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p...    85   1e-15
UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc...    85   1e-15
UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus...    84   2e-15
UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth...    78   2e-13
UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    78   2e-13
UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre...    77   3e-13
UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti...    77   5e-13
UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact...    71   2e-11
UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba...    71   2e-11
UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac...    66   5e-10
UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase...    62   1e-08
UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax...    59   7e-08
UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    59   1e-07
UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas...    58   2e-07
UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm...    54   2e-06
UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax...    53   8e-06
UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID...    49   1e-04
UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip...    48   1e-04
UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax...    46   6e-04
UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp....    45   0.001
UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog...    44   0.003
UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma...    43   0.006
UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Glucona...    43   0.006
UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact...    43   0.008
UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1...    43   0.009
UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R...    42   0.012
UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ...    42   0.013
UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY...    42   0.013
UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferro...    41   0.023
UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC...    41   0.024
UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax...    41   0.024
UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm...    41   0.024
UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID...    41   0.025
UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str...    41   0.026
UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber D...    41   0.027
UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ...    41   0.028
UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus...    41   0.030
UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip...    41   0.033
UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil...    41   0.035
UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=...    41   0.036
UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB...    41   0.037
UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG fami...    40   0.039
UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus...    40   0.060
UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus k...    40   0.060
UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermo...    39   0.072

>UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT
          Length = 215

 Score =  283 bits (724), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 98/196 (50%), Positives = 135/196 (68%), Gaps = 2/196 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   +  VLMLGYMN EA  KT+E+ KVTF+SR++  LWTKGETS
Sbjct: 2   QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126
           GN+L++VSI  DCDNDTLLV  +P GPTCH GT +C+G+T   +  LFL +L+  +  R 
Sbjct: 62  GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P+ SYT  L+  G ++IAQKVGEE VET + A   +   L  EASD++YHL+VLL  
Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181

Query: 187 QGLDLTTVIENLRKRH 202
           +GL +  +   L +RH
Sbjct: 182 KGLHIEDLARELARRH 197


>UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C4Y5_SPHTD
          Length = 228

 Score =  280 bits (716), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 86/195 (44%), Positives = 118/195 (60%), Gaps = 9/195 (4%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGETSGN   VV 
Sbjct: 23  GLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGETSGNVHEVVE 82

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQLEQLLAERKS 127
           I PDCD D LLV   P GPTCH GT +CF                  + ++ +++AER++
Sbjct: 83  IRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDEVARVVAERRA 142

Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
              E SYT  L  +G  +I +K+GEE  E  +AA   D   L NEA+DL+YHLLVLL+  
Sbjct: 143 HPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLIYHLLVLLEAS 202

Query: 188 GLDLTTVIENLRKRH 202
            +    V   LR R 
Sbjct: 203 DVPTERVWAVLRTRR 217


>UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria
           RepID=C6J1M1_9BACL
          Length = 231

 Score =  277 bits (708), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 93/213 (43%), Positives = 129/213 (60%), Gaps = 13/213 (6%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            E   + + W+   GL+P IVQ A S EVLML YMN E+L K++E+G+  F+SR++  LW
Sbjct: 15  IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA------------H 110
            KG TSGN   + ++  DCD DTLLV     GP CH G  +CF  TA             
Sbjct: 74  NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           ++  L +LEQL+AER +  PE +YT  L+  G  +I +KVGEE  E+ +AA   D  EL 
Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E SDL+YHLLVLL+++ L L  +++ L +RH+
Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226


>UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria
           RepID=HIS2_VIBVY
          Length = 211

 Score =  276 bits (707), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 129/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
                   ++WEK DGL+P IVQ   S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL
Sbjct: 7   EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG---DTAHQWLFLYQL 118
           WTKGETSGN L +V+++ DCDNDTLLV  NPIGPTCH GT++C+        Q ++L+QL
Sbjct: 67  WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT  D+ EL  E++DL+Y
Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLLVLLQDQGL +  VI  L++RH+
Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211


>UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria
           RepID=C6PCK8_CLOTS
          Length = 228

 Score =  276 bits (706), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 80/204 (39%), Positives = 119/204 (58%), Gaps = 9/204 (4%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L ++   GL+P IVQ   + EVLM+ YMN E+L+K+LE+ +  FFSR++Q LW KG
Sbjct: 8   NIDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKG 66

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------DTAHQWLFLYQ 117
           ETSGN  ++ +I  DCD DTLLV   P GP CH G +SCF         +   +   L  
Sbjct: 67  ETSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSN 126

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + +  RK      SYT  L+  G  +I +K+GEE  E  +A+    + E+  E +D +
Sbjct: 127 LYRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYI 186

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YHL+VL+ ++G++L  V + + KR
Sbjct: 187 YHLMVLMVEKGINLNDVYKEISKR 210


>UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae
           RepID=C4V2J2_9FIRM
          Length = 235

 Score =  270 bits (692), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 77/204 (37%), Positives = 112/204 (54%), Gaps = 19/204 (9%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   + +VLML YMN E+L+KT+E+G   ++SR++Q+LW KGETSGN   +  
Sbjct: 15  GLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQKLWKKGETSGNVQRIKE 73

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFG------------------DTAHQWLFLYQL 118
           I+ DCD DT+L+     G  CH GT SCF                   +       L  L
Sbjct: 74  ISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIPLIEKEEHPLTEVLASL 133

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            Q++  R+    E SYT  L+  G  +I +K+GEE  ET +A+  + R ++  E  DL Y
Sbjct: 134 YQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASKNNIREDVLYEMGDLWY 193

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           H LVLL    +    ++E L++R+
Sbjct: 194 HCLVLLAYHNMTPEDLLEELKRRN 217


>UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=A9B1U1_HERA2
          Length = 212

 Score =  270 bits (691), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 104/203 (51%), Positives = 130/203 (64%), Gaps = 10/203 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           EL ++ + GL+P +VQHA SGEVLM+GYMN EAL KT  SG VTF+SR++Q+LWTKGETS
Sbjct: 3   ELTYD-SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH---------QWLFLYQLE 119
           GN L  ++   DCDND LL+LA P GPTCH G+ SCF  T              F+ QL 
Sbjct: 62  GNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLF 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + L ER+   P  SYT  L   G  +I +K+GEE  E  +AA   +  EL NEASDL+YH
Sbjct: 122 EFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYH 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           L VLL +QG+    V   LR+RH
Sbjct: 182 LFVLLLNQGVSPEDVWFTLRERH 204


>UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms
           RepID=HIS2_SYNPX
          Length = 222

 Score =  270 bits (690), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 71/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L+     +L + +  GL+P I Q  + G VLM+ +MN E++ +TL SG+  ++SR++Q L
Sbjct: 4   LSPAFIDQLRFNEA-GLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTA----------- 109
           W KG TSG+   + SI  DCD D LL+     G   CH G  SCF +             
Sbjct: 63  WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122

Query: 110 -HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                   +L +++  R+    E SYT KL   G  +I +K+GEE  E  +A    +  E
Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  EA+D+++H+ V L   G+    V E L  R 
Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216


>UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria
           RepID=B5EQF3_ACIF5
          Length = 230

 Score =  269 bits (689), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 82/204 (40%), Positives = 114/204 (55%), Gaps = 12/204 (5%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + W   DGL+P I Q A SG VLML +MN +AL  TL  G  T++SR++Q LW KGETSG
Sbjct: 15  VRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRKGETSG 73

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-----------DTAHQWLFLYQL 118
           +  ++V +  DCD DTLL+     GP CH G  +CF                    L  L
Sbjct: 74  HIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGSILDSL 133

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           +  L  R++ADP  SY A+L   G  RI +KVGEE  E  +A   H+   +  EA+DL++
Sbjct: 134 QVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEAADLVF 193

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HL+V L+++ L +  V+  L +R 
Sbjct: 194 HLMVALEERDLHIDDVLGELARRE 217


>UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Legionella
           RepID=C6N0X1_9GAMM
          Length = 207

 Score =  268 bits (685), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 95/195 (48%), Positives = 131/195 (67%), Gaps = 1/195 (0%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LDW+K +GL+P I+Q+A +G VLMLGYMN EAL  T+ +G++T +SR+++RLW KGETSG
Sbjct: 9   LDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGETSG 68

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLEQLLAERKSA 128
           N + V  I+ DCD+D+LL++  P GP CH G +SC+    H    F+  L +++ ER   
Sbjct: 69  NTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINERAET 128

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
             E SYTA+L ASG  R AQKVGEE VET +AA      E  NE +DL++HLLVLL+   
Sbjct: 129 QAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLKASE 188

Query: 189 LDLTTVIENLRKRHQ 203
           L    V++ L+ R +
Sbjct: 189 LSFYDVLQCLQDRDR 203


>UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria
           RepID=Q2JWX9_SYNJA
          Length = 231

 Score =  267 bits (684), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 79/198 (39%), Positives = 108/198 (54%), Gaps = 9/198 (4%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P IVQ  + G VLM+ +MN E+L KTLE+G+  F+SR++Q LW KGETSG+   
Sbjct: 31  NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQW 90

Query: 74  VVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAE 124
           V  I  DCD+D L++L   +G   CH G  SCF        GD       L Q+  ++  
Sbjct: 91  VKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKA 150

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R++     SYT+ L A G   I +K+GEE  E  +AA   D+  L  E +DL YH LV L
Sbjct: 151 RQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVAL 210

Query: 185 QDQGLDLTTVIENLRKRH 202
               +D+  V   L+ R 
Sbjct: 211 AHHQVDIRDVYRQLQARR 228


>UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae
           RepID=C5SM65_9CAUL
          Length = 215

 Score =  266 bits (681), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 111/202 (54%), Positives = 137/202 (67%), Gaps = 1/202 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LT      LD+ K DGL+P IVQ A + +VLMLGYM+  AL +TL   +VTFFSR+K   
Sbjct: 11  LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG-DTAHQWLFLYQLEQ 120
           W KGETSG+FLN+VS+  DCD D LLVLA P+GPTCH  T+SCFG DTA    F+  L  
Sbjct: 71  WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ +R  A P  SYTA+L   G  +IAQKVGEEG+ETALA    D  EL NEA+DL+YHL
Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
            VLL  +   L  V++ LR+RH
Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212


>UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes
           RepID=HIS2_OCEIH
          Length = 215

 Score =  265 bits (679), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 82/191 (42%), Positives = 116/191 (60%), Gaps = 5/191 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P IVQ   SG+VL L YMN +++ KT+E+ +  F+SR +Q LW KG TSGN   V  
Sbjct: 16  GLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQELWNKGATSGNKQTVKQ 75

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LYQLEQLLAERKSADPE 131
           I+ DCD D +LVL +  GP CH G  SCF +  ++        + Q+   + ER     E
Sbjct: 76  ISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQIIPQVSAKIKERHEHPVE 135

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            +YT+ L+  G  +I +K+GEE  E  +AA   D+ ELT+E SDL+YH LVL++ QG+ L
Sbjct: 136 GAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSDLLYHSLVLMEQQGVTL 195

Query: 192 TTVIENLRKRH 202
             + + L KRH
Sbjct: 196 EDIKKELYKRH 206


>UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria
           RepID=HIS2_BLOFL
          Length = 213

 Score =  265 bits (677), Expect = 8e-70,   Method: Composition-based stats.
 Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT ++ + L+W K  GL+P I+QH++SGEVLMLGYMN E++  T ++G VTFFSR+K R
Sbjct: 1   MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGE+SGN L +++  PDCD D+LL+L  P G TCHK T+SCF      + FL+QLE 
Sbjct: 61  LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120

Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +K+      + ++SYT+ LY SG +RIAQKVGEEG+ETALAA   +   L +EASD
Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+YHLLVLLQ + L+   VI+ LR R +
Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208


>UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3
           Tax=Clostridiales RepID=C4Z9Z2_EUBR3
          Length = 427

 Score =  264 bits (675), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%)

Query: 1   MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           +L +    +L W      +DG++PVIVQ   + +VLML YMN EA + T+ SG++T++SR
Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108
           ++  LWTKG TSG+   V S+  DCD DT+L   + +G  CH    +CF +         
Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            +    L  +  ++ +R     E SYT  +   G   I +K+G E  E  LAA   D  +
Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           L  E SD MYH ++L+  + +    +   L +R
Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427


>UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria
           RepID=HIS2_XANCP
          Length = 206

 Score =  262 bits (669), Expect = 7e-69,   Method: Composition-based stats.
 Identities = 115/197 (58%), Positives = 135/197 (68%), Gaps = 2/197 (1%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW K DGL+PVIVQ A +  VLMLGYMN EAL  T   G+VTFFSR+KQRLWTKGE
Sbjct: 12  LDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGE 71

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGN L VV+I  DCD DTLLV A P GPTCH G +SCF        FL  L+ L+AER+
Sbjct: 72  SSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCF--PTAPSQFLGSLDALIAERE 129

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P  SYT KL+  G +RIAQKVGEEGVETALA  V    EL  E++DL+YHL+VLL+ 
Sbjct: 130 HERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRA 189

Query: 187 QGLDLTTVIENLRKRHQ 203
           +GL L   +  L  RH+
Sbjct: 190 RGLGLGDAVALLESRHK 206


>UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=10 Tax=Bacteria
           RepID=C0QVS5_BRAHW
          Length = 220

 Score =  261 bits (668), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 77/203 (37%), Positives = 116/203 (57%), Gaps = 6/203 (2%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           + +  +L ++   GL+P IV    + EVL L YMN E+L+ +++  K  F+SR++Q LW 
Sbjct: 6   QNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQELWR 64

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQL 118
           KGETSGN+ ++ SI  DCDND L++     GP CH G+ SCF +       ++   + +L
Sbjct: 65  KGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSIDKL 124

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            +L+  RK    E SYT  L+ SG  +I +KVGEE  E  + A      E   E SDL+Y
Sbjct: 125 YKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDLLY 184

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H LVL+ ++G+ +  +   L  R
Sbjct: 185 HSLVLMVEKGITINDIKNELASR 207


>UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1
           Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL
          Length = 207

 Score =  261 bits (668), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 100/195 (51%), Positives = 134/195 (68%), Gaps = 1/195 (0%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +D+EK +GL+PV+VQ A + +VL L YM+  ALD+T++SG+ TFFSR++   W KGETSG
Sbjct: 7   IDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGETSG 66

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-FLYQLEQLLAERKSA 128
           + L+VV I  DCD+D L++  NP+G  CH   +SCFG      L  + +LEQ +AER +A
Sbjct: 67  DRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERAAA 126

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP  S+TAKL   G KRIAQKVGEEGVETALA       EL +EA+DL+YHLLVLL  + 
Sbjct: 127 DPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHARN 186

Query: 189 LDLTTVIENLRKRHQ 203
           +    V++ L  R +
Sbjct: 187 MVFQDVLDVLASRAE 201


>UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae
           RepID=B4U8T9_HYDS0
          Length = 207

 Score =  258 bits (660), Expect = 9e-68,   Method: Composition-based stats.
 Identities = 81/205 (39%), Positives = 118/205 (57%), Gaps = 9/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+PVI Q A SGE+ ML Y N EA+ KT+E+G   +FSR++  +W KGE
Sbjct: 3   IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCF---GDTAHQWLFLYQ----L 118
           TSG    V+ I  DCDNDTL+ +        CH G  +CF    D     L  ++    L
Sbjct: 62  TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E+L+ +R S   E+SYT+KL   G  RI QKVGEE +E+ +A    D+ E+  E +DL+Y
Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           H+LV ++   +    V   L +RH+
Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206


>UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius
           thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ
          Length = 211

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 89/201 (44%), Positives = 118/201 (58%), Gaps = 14/201 (6%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V 
Sbjct: 8   DGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIVT 67

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------GDTAHQWLFLYQLEQL 121
           S+  DCD DTLL L  P GP CH G +SCF               D       L  L QL
Sbjct: 68  SLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQL 127

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + +R    P+ SY  KL   G  ++ +KVGEE  E   A    D+ E+ +E++DL++H L
Sbjct: 128 IEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHTL 187

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
           + L+   +DL+ V++ L  RH
Sbjct: 188 LALKYFQVDLSEVLQELHNRH 208


>UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI
          Length = 244

 Score =  256 bits (655), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 85/218 (38%), Positives = 115/218 (52%), Gaps = 27/218 (12%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + W+   GL+P I Q ++S EVLML YMN EAL+ TL++G   +FSR+KQR+W KGE SG
Sbjct: 6   IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------------- 106
           N   V  I  DCD+D++L+  N  G  CH G  SCF                        
Sbjct: 65  NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124

Query: 107 ---DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
               + + +  L  L   L ERK+AD  TSYTA L+A GT  IA+K+ EE  E   A   
Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            D  E+  E +D+ YH+LV L  + +    + + L KR
Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222


>UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms
           RepID=HIS2_THEP3
          Length = 216

 Score =  255 bits (652), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 80/215 (37%), Positives = 115/215 (53%), Gaps = 22/215 (10%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E   +EL ++   GL+PVI Q   + EVLM+ Y+    L K+LE+GKV +FSR++ +LW 
Sbjct: 2   ENILKELKFDDR-GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107
           KGETSG+F  + SI+ DCD DTLL+    +   CH G  SCF                  
Sbjct: 61  KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120

Query: 108 -----TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
                 A     L ++  ++ +R     E SYT  L+  G  +I +KVGEE  E  + A 
Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             D+ E+  E SDL+YHLLVL+ ++G+ L  + E 
Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215


>UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms
           RepID=C9RV77_GEOSY
          Length = 216

 Score =  255 bits (651), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 97/203 (47%), Positives = 128/203 (63%), Gaps = 10/203 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++ ++   GL+P IVQ A S EVL L YMN E+L+KTLE+G+  F+SR++Q LW KG TS
Sbjct: 4   DIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGATS 62

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------TAHQWLFLYQLE 119
           GN   VV I  DCD D LLVL  P GP CH G+ SCF            A ++  L +LE
Sbjct: 63  GNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNELE 122

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           Q++A+R +  PE SYT  L+  G  +I +KVGEE  E  +AA   +  EL  EA+DL+YH
Sbjct: 123 QIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLYH 182

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           LLVLL++Q L L  V+  L +RH
Sbjct: 183 LLVLLREQKLPLDAVLATLAERH 205


>UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga
           RepID=HIS2_THEMA
          Length = 197

 Score =  253 bits (648), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 84/194 (43%), Positives = 112/194 (57%), Gaps = 8/194 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+VQ   +GEVLML Y N EAL+ T ++G   FFSR +Q++W KGETSGN + VV I
Sbjct: 4   LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63

Query: 78  APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQ------WLFLYQLEQLLAERKSAD 129
             DCD+D  L + +       CH G  SCF    H+        F  +L +L+ +RK   
Sbjct: 64  RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT KL+  G  +IA+K GEE VE       +DR  L  E +D+MYHL VL+ D G+
Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183

Query: 190 DLTTVIENLRKRHQ 203
            +  V+  L KR +
Sbjct: 184 TVQDVMRELEKRRK 197


>UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius LAA1 RepID=B7DRK3_9BACL
          Length = 254

 Score =  252 bits (644), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 78/247 (31%), Positives = 115/247 (46%), Gaps = 49/247 (19%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           + +   + ++   GL+PV+ Q A +GEVLM+ Y + EAL +TL +G   ++SR+++  W 
Sbjct: 7   DVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRREYWR 66

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF------------------ 105
           KG TSGN   VV +  DCD D +L    P GP CH G  +CF                  
Sbjct: 67  KGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAADEGG 126

Query: 106 --------------------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLY 139
                                     G        L +L  ++  R    P+ SYT  L+
Sbjct: 127 AKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTTYLF 186

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDLTTV 194
             G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+    V
Sbjct: 187 THGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHPVDV 246

Query: 195 IENLRKR 201
              L KR
Sbjct: 247 WRTLEKR 253


>UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC
          Length = 251

 Score =  252 bits (643), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 80/237 (33%), Positives = 120/237 (50%), Gaps = 40/237 (16%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           + + ++DW+K  GL+PV++Q   +GEVLM+ YMN EAL+ T  +G   +FSR+K R+W K
Sbjct: 3   ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107
           GE+SGN   V S   DCDNDTLL+     G  CH G  SCF +                 
Sbjct: 62  GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121

Query: 108 TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           +  ++  L +L  +  +RK +ADP+ SY AKLY  G     +K+ EE  E A A     R
Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181

Query: 167 F---------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                                 ++  E +DL++H++V L   G+    ++  L +R+
Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238


>UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=1 Tax=Candidatus Poribacteria
           sp. WGA-A3 RepID=D2MIV8_9BACT
          Length = 234

 Score =  252 bits (643), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 77/198 (38%), Positives = 110/198 (55%), Gaps = 13/198 (6%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P +VQ    G +LML YMN EALD+TL++G V F+SR++++LW KGETSG++L    
Sbjct: 22  GLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSGHYLLCKR 81

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFG-------------DTAHQWLFLYQLEQLLA 123
           +  DCD D LLV A P GPTCH    +CF                        +L +++ 
Sbjct: 82  VFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFDRLYEMVL 141

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +RK+   E SY + L   G  RI +KV EE  E  LA     R E+ +E +DL++H +V 
Sbjct: 142 QRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADLIFHSIVA 201

Query: 184 LQDQGLDLTTVIENLRKR 201
           L    + +T + + L KR
Sbjct: 202 LGHCEIPMTAIQQELGKR 219


>UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WUY1_ALIAD
          Length = 256

 Score =  251 bits (641), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 80/255 (31%), Positives = 117/255 (45%), Gaps = 54/255 (21%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +   + ++   GL+PV+ Q A +G+VLML Y + EAL +TL +G   ++SR+++ 
Sbjct: 1   MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105
            W KG TSGN   VV +  DCD D +L    P GP CH G   CF               
Sbjct: 61  YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120

Query: 106 ----------------------------------GDTAHQWLFLYQLEQLLAERKSADPE 131
                                             G  A     L +L  ++  R    P+
Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186
            SYT  L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL + 
Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240

Query: 187 QGLDLTTVIENLRKR 201
            G+    V + L KR
Sbjct: 241 VGVQPADVWQVLEKR 255


>UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=4 Tax=Flavobacteriales
           RepID=A4CLC1_9FLAO
          Length = 206

 Score =  250 bits (640), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 94/203 (46%), Positives = 129/203 (63%), Gaps = 6/203 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            + +D+EKT GL+P I+Q + +  VLMLGYM+ EAL+ T  SGKVTF+SR+K+RLWTKGE
Sbjct: 1   MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-AHQWLFLYQLEQLLAER 125
           +SGNFL  V +  DCD D LL+ A P GP CH G+ +C+ +       FL +LE ++A R
Sbjct: 61  SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120

Query: 126 KSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           K           SY A L   GT ++AQKVGEE VET + A   D     NE++DL++H 
Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           L+LLQ +G  +  +   L +RH+
Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203


>UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc
           (Cinara cedri) RepID=Q058A1_BUCCC
          Length = 205

 Score =  250 bits (639), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 93/204 (45%), Positives = 131/204 (64%), Gaps = 1/204 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           ML +Q  + L+W K +GL+P I QH +SGE+LM GYMN +A DK + +   T +SR K+R
Sbjct: 1   MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLE 119
           +W KGETS NFL V +I+ DCD D +LV  NP G TCH    SCF       + FLY+LE
Sbjct: 61  IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
             +  +K     +SY + L++SG  RIAQK+GEE VE  +A   ++   + NE SDL++H
Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           L +LLQ   ++L  +I+NL+KR +
Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204


>UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria
           RepID=HIS2_HELHP
          Length = 231

 Score =  247 bits (632), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +   R++DWE+ + L+P IVQ   S ++LML Y + ++L+ +L++    +FSR+KQR+W 
Sbjct: 2   QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107
           KGE SG+  ++  +  DCDND+L+ +   +G  CH G  SCF                  
Sbjct: 61  KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120

Query: 108 ---TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                  +  L  L  ++ +R+  + E SYTA L A G   I +K+ EE  E   A    
Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D   +  E +DL YH+LV L  + +    V++ LR+R
Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217


>UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Picrophilus torridus
           RepID=Q6KZD6_PICTO
          Length = 204

 Score =  247 bits (632), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 74/205 (36%), Positives = 116/205 (56%), Gaps = 15/205 (7%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            +++   DG++PV+VQ   +G+VL L YM+  AL+ T+++G   ++SR+ +R+  KGE S
Sbjct: 5   NINF--NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVS 62

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF----------GDTAHQWLFLYQL 118
           GN   V+ I  DC++++LL+     GP CH G +SCF          G+  +    L +L
Sbjct: 63  GNTQKVMEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRL 122

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E L+ +R       SYT  L  SG + I +KVGEE +ET LA+    R  +  E +DL+Y
Sbjct: 123 EDLVRKRMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILAS---GRDRIVYETADLLY 179

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HL+V L    + L  V+  L +R +
Sbjct: 180 HLIVFLAFNNVSLFDVMNELNRRSK 204


>UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae
           RepID=D0LRT4_HALO1
          Length = 241

 Score =  246 bits (628), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 85/204 (41%), Positives = 117/204 (57%), Gaps = 16/204 (7%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L 
Sbjct: 21  NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---------------GDTAHQWLFLYQL 118
           V  +  DCD D ++V+A P GPTCH GT SCF               G +      L +L
Sbjct: 81  VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140

Query: 119 EQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           E ++A R+ SAD E SYT  L   G  +I  K+ EE  E A      +R E+ +E +DL+
Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           +H++V L  + + L  V   L +R
Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224


>UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_PYRFU
          Length = 209

 Score =  245 bits (626), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 90/213 (42%), Positives = 124/213 (58%), Gaps = 14/213 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  E+   +++WEK +G++PVIVQ    GEVL L YMN EAL KTLE+G   ++SR+K R
Sbjct: 1   MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-------- 112
           +  KGE SGN   V  I  DCDND LL++ +P GP CH G  SCF     +         
Sbjct: 60  IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119

Query: 113 --LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE+++  RK    E SYT+KL+  G ++I +K GEE +E  +A     R  + 
Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E +DL+YHLLVLL    + L  V+  LR+R +
Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209


>UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TLB5_9BACT
          Length = 188

 Score =  245 bits (626), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 88/187 (47%), Positives = 116/187 (62%), Gaps = 5/187 (2%)

Query: 22  IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81
           +VQ A SGEVLML Y N E++  TLE G++ F+SR+++ +W KG TSGN L + S+  DC
Sbjct: 2   VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61

Query: 82  DNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQLLAERKSADPETSYTA 136
           D D +L   +P+GP CH G  SCF     G+     +FL +L   L +R    PE SYTA
Sbjct: 62  DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +L A    R+AQK+GEEGVETALA    DR +   EA+DL+YHLLV L    L    +  
Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181

Query: 197 NLRKRHQ 203
            L+KRH+
Sbjct: 182 ELKKRHK 188


>UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KI1_SYMTH
          Length = 210

 Score =  245 bits (625), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%)

Query: 27  VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86
            +G+VLM  YMN EAL  TLE+G   ++SR++Q LW KG TSG+   V  I  DCD D+L
Sbjct: 2   RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61

Query: 87  LVLANPIGPTCHKGTSSCFGDTAHQW-----------------------LFLYQLEQLLA 123
           L+L    G  CH+GT SCF                                L +L  +LA
Sbjct: 62  LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ER++     SYT++L+  G     +K+GEE  E  LA    DR  L  E +DL +H LV 
Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181

Query: 184 LQDQGLDLTTVIENLRKRH 202
           L DQGL    V + L  R 
Sbjct: 182 LVDQGLSPADVADQLASRR 200


>UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B858_THEAS
          Length = 205

 Score =  244 bits (624), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 95/202 (47%), Positives = 120/202 (59%), Gaps = 6/202 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              ++W   D L+PV+VQ A SG VLML Y N EALD TL+ G+  FFSR++ RLW KGE
Sbjct: 2   TDRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWLFLYQLEQL 121
           TSGN + V+ +  DCD D++L L    GP CH G  SCF     G      LFL++L ++
Sbjct: 61  TSGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEI 120

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + +R S   + SYT  L+  G  RIAQKVGEEGVE ALA    DR     EA+DL+YHL 
Sbjct: 121 VDQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLT 180

Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203
           V L+     L    + L  RHQ
Sbjct: 181 VALRRVDATLLDAEQVLMARHQ 202


>UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP
           cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NG19_KYTSD
          Length = 244

 Score =  242 bits (619), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 98/229 (42%), Positives = 128/229 (55%), Gaps = 35/229 (15%)

Query: 9   ELDWEKTD----GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           E+D+ +      GL+  +VQ A +  VLM+G+M+  AL+ T  +G+VTF+SR++   W K
Sbjct: 15  EVDFSRVTDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVK 74

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF------------------- 105
           GETSGN L+VVS+  DCD D +LV+A P GPTCH G +SCF                   
Sbjct: 75  GETSGNTLDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAA 134

Query: 106 ------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEE 153
                       G T      +  L + +AER    P  SYT  L+  GT+RIAQKVGEE
Sbjct: 135 SGAGGDAPASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEE 194

Query: 154 GVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           GVETALA       EL  E++DL+YHL+VLL D+GL L  V   LR R 
Sbjct: 195 GVETALAGVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243


>UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP
           pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN
          Length = 215

 Score =  241 bits (616), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 84/205 (40%), Positives = 112/205 (54%), Gaps = 8/205 (3%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              E+ ++  +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++  LW KG
Sbjct: 2   NIEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKG 60

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL------- 118
             SGN   V+ +  DCD D +L    P GP CH G  +CF            L       
Sbjct: 61  AISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKV 120

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + L  R    PE SY  K++ +G  RI +K+GEE  E  +AA    R EL  EASDL++
Sbjct: 121 YRTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLF 180

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLL  L + GL    +   L +R+Q
Sbjct: 181 HLLFTLTELGLSPQDLARVLWERNQ 205


>UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes
           RepID=C6W0Y7_DYAFD
          Length = 213

 Score =  241 bits (615), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 106/211 (50%), Positives = 137/211 (64%), Gaps = 12/211 (5%)

Query: 5   QQRRELDWEKT-DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    +D+ K+ DGL+P ++Q   +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT
Sbjct: 3   ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWL 113
           KGETSGNFL V  IA DCD DTLL+ A P GP CH G  +CFG+           A +  
Sbjct: 63  KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122

Query: 114 FLYQLE-QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           FL  L+ +++ ERK    + SYT+ L+  G  +IAQKVGEE VE  + +   D     NE
Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            SDL++HLLVLL+ + +DL  VI+ LR RHQ
Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213


>UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum
           sp. NBC37-1 RepID=A6Q6T8_SULNB
          Length = 222

 Score =  241 bits (615), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +DW K + L+P I Q A + +VLML YMN EA + TL +G   +FSR+KQR+W KGE+SG
Sbjct: 3   IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115
           +   V  +  DCD DT+++     G  CH G  SCF               DT   +  +
Sbjct: 62  HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121

Query: 116 YQLEQLLAERKSADPET-SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
             L   + ERK+A  E  S+T KL     + +  K+ EE  E  +A       ++  E++
Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV L  + +    V + L +R
Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207


>UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3
           Tax=Chloroflexi RepID=B9KXC5_THERP
          Length = 218

 Score =  240 bits (613), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 85/196 (43%), Positives = 118/196 (60%), Gaps = 8/196 (4%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KGETSG+ L +
Sbjct: 17  ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKGETSGHVLEL 76

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------GDTAHQWLFLYQLEQLLAERK 126
           V +  DCD D LL   +P GPTCH G  SCF                 L +L  ++A R 
Sbjct: 77  VELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILDELASIIAARA 136

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
                 SYT+ L  +G  RIA+K+GEE  E  +AA   +   +  EA+DL+YHLLVLLQ 
Sbjct: 137 VEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLLYHLLVLLQA 196

Query: 187 QGLDLTTVIENLRKRH 202
            G+    V   L+ R 
Sbjct: 197 SGVPAGEVWRVLQARR 212


>UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT
          Length = 233

 Score =  240 bits (612), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 89/196 (45%), Positives = 124/196 (63%), Gaps = 6/196 (3%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           + K D L+P +VQH  +G+VLMLGYM  EA + T  +GKVTFFSR+++++W KGETSGN 
Sbjct: 21  FGKAD-LIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSRKKIWVKGETSGNG 79

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-----HQWLFLYQLEQLLAERK 126
           L+V+ I  DCD DT+LVLA P+GPTCH G+ SCF  +        +    +L+  + ERK
Sbjct: 80  LDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFEVWSELQSTVRERK 139

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           + DP+ SYTA L  S    + +K+ EE  E +LA  V  R    +E +DL +H+ V L+ 
Sbjct: 140 TGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEWADLFFHIAVALEK 199

Query: 187 QGLDLTTVIENLRKRH 202
            G+    V+E LRKR 
Sbjct: 200 TGVSWGEVMEILRKRQ 215


>UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera
           aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR
          Length = 204

 Score =  239 bits (611), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 95/203 (46%), Positives = 129/203 (63%), Gaps = 1/203 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT  Q  +L+W+K + L+P+IVQ   S E+LM GY N ++L  TL+  K+TFFSRTK R
Sbjct: 1   MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH-QWLFLYQLE 119
           LWTKGETS N+L V+ I PDCD D+LL L   IG TCH    SCF    +    F+ +LE
Sbjct: 61  LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           ++L   K  +  TSYT+ LY  G  +I+QKVGEE VE  +AA   D+  +  E +DL+YH
Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVL     +    +I+ L+KR+
Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203


>UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria
           RepID=HIS2_AQUAE
          Length = 205

 Score =  238 bits (607), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 74/199 (37%), Positives = 113/199 (56%), Gaps = 9/199 (4%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             +GL+PVI Q   +GEV ML Y N EA+ KTLE+G   ++SR+++++W KGETSG    
Sbjct: 7   NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETSGELQK 66

Query: 74  VVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFGDTAH--------QWLFLYQLEQLLAE 124
           V+ +  DCD D L+ +        CH G  +CF              +  L +L+ ++ E
Sbjct: 67  VIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQDVIRE 126

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           +     E SYTAKL + G +R+ QK GEE VET +A    ++ E+  E++D++Y  LV L
Sbjct: 127 KIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYTFLVSL 186

Query: 185 QDQGLDLTTVIENLRKRHQ 203
              G+D+  V+E L +R +
Sbjct: 187 SVSGIDIKEVMEELIRRFK 205


>UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_THET2
          Length = 214

 Score =  236 bits (602), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 81/192 (42%), Positives = 115/192 (59%), Gaps = 5/192 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGETSG+   VV 
Sbjct: 12  GLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGETSGHTQEVVE 71

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-----AHQWLFLYQLEQLLAERKSADPE 131
           +  DCD D ++    P GP CH G  +CF              + Q+   + ER    PE
Sbjct: 72  VLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYATIKERLRTLPE 131

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            SY A+++ +G  RI +K+GEE  E  LAA   +  EL +EA+DL++HLL+ L + GL  
Sbjct: 132 GSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLLLTLAELGLTP 191

Query: 192 TTVIENLRKRHQ 203
             + + L +RH+
Sbjct: 192 EDLAKTLWERHR 203


>UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS
          Length = 257

 Score =  235 bits (599), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 82/244 (33%), Positives = 116/244 (47%), Gaps = 43/244 (17%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M   Q   E+ +    GL+P I QH  +G +LM+ +MN E+L  T E  +  +FSR++Q+
Sbjct: 1   MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCF-------------- 105
           LW KGE SG+F  V  I  DCD D +++     G   CH G  SCF              
Sbjct: 60  LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119

Query: 106 --------------------GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKR 145
                                 T  Q   L  L QL+ ERK A+ +TSY + LY  G  +
Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179

Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           I +KVGEEGVET +AA          +  +L  E +DL +H +V+L    L+   +I+ L
Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239

Query: 199 RKRH 202
            +R 
Sbjct: 240 GRRQ 243


>UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT
          Length = 230

 Score =  233 bits (594), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 87/197 (44%), Positives = 116/197 (58%), Gaps = 10/197 (5%)

Query: 15  TDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
            DG  L PV+ Q    G+VLM+GYMN EA  +T+E G+VTFFSR+++RLWTKGE+SG+FL
Sbjct: 11  PDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWTKGESSGHFL 70

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------DTAHQWLFLYQLEQLLAE 124
            +VS+  DCD DTLL L  P GPTCH GT SCF         +    +  L  L   +A 
Sbjct: 71  RLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETLGDLAGTIAL 130

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R+  DPETSY A+L +     + +K+ EE  ET  A    D     +E +DL++HLLV +
Sbjct: 131 RRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMADLLFHLLVAM 190

Query: 185 QDQGLDLTTVIENLRKR 201
           +        V+  L KR
Sbjct: 191 ERTRTPWEEVVGVLEKR 207


>UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4L5_GEMAT
          Length = 207

 Score =  233 bits (594), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 81/204 (39%), Positives = 112/204 (54%), Gaps = 5/204 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M +      LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++  
Sbjct: 1   MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG TSG+   V+S+A DCD D +L      GP CH GT+SCF DTA     +  L+ 
Sbjct: 60  LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119

Query: 121 LLAERKS---ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
            +A R+     D   SYT +L      R  +K+GEE VE A A    D    T E +DL+
Sbjct: 120 TIAARQQSLRDDERPSYTQRLLTDRNLR-LKKLGEEAVELATACVDGDVERATEETADLL 178

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YH LV L+  G  L  V   L +R
Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202


>UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=2 Tax=Francisella philomiragia
           RepID=B0TY40_FRAP2
          Length = 207

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 102/201 (50%), Positives = 137/201 (68%), Gaps = 3/201 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + W+K D L+P I+Q A+   VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTK
Sbjct: 4   KIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTK 63

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL--FLYQLEQLL 122
           GE SGNFL +  IA DCDND++L+ A P GPTCH G+ SCF           + +LE+L+
Sbjct: 64  GEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLI 123

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMYHLL 181
           AE+K   PE SY   L+  G  RIAQKVGEEGVE  +AA   D   EL +E +DL++HLL
Sbjct: 124 AEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLL 183

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
           VLL+++G+ L  + + L  R+
Sbjct: 184 VLLREKGISLEQICQKLVSRN 204


>UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5
          Length = 229

 Score =  229 bits (585), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 85/199 (42%), Positives = 113/199 (56%), Gaps = 15/199 (7%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQ  ++G+V ML YM  E+L +TLE+G+ TFFSR++  LW KG TSGN L V S+
Sbjct: 10  LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCF-------GDTAHQWLFLYQ--------LEQLL 122
             DCD D LL+LA P GPTCH G++SCF       GD   +     Q        LE+ L
Sbjct: 70  HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
             RK++    SYT KL   G   I  K+ EE  E A A        + +EA+D++YHLLV
Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L  +G+ L  V+  L  R
Sbjct: 190 GLASRGVPLRAVLSALASR 208


>UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
           n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD
          Length = 202

 Score =  229 bits (584), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 76/200 (38%), Positives = 109/200 (54%), Gaps = 9/200 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+   W KG 
Sbjct: 4   LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER- 125
           TSGN   VV++  DCD D +L      GP CH GT +CFG    +W  L  L+  LA R 
Sbjct: 63  TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFG--PGRWDALSALDDTLARRA 120

Query: 126 ----KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
               +  D   SYT +L      R  +K+GEE  E   A    D      EA+D++YH+L
Sbjct: 121 APAERPDDAPPSYTRRLLEDRNLR-LKKLGEEAAELVTACADVDPSRAAEEAADVLYHVL 179

Query: 182 VLLQDQGLDLTTVIENLRKR 201
           V ++  GL L  V   L +R
Sbjct: 180 VAVRPLGLSLDDVKAVLARR 199


>UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8HTA8_CHLRE
          Length = 308

 Score =  223 bits (569), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 73/226 (32%), Positives = 117/226 (51%), Gaps = 31/226 (13%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L W+K + L+ VIVQH  +GEV+M  + +  A+ +TL++G  TF+SR++   W K
Sbjct: 67  SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH-------------- 110
           GETSG+F+NV ++  DCD D+++ L++PIGP CH G  +C+                   
Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185

Query: 111 --------QWLFLYQLEQLLAERKSAD------PETSYTAKLYASGTKRIAQKVGEEGVE 156
                       L  LE+ +A+R+ A        + S+TA+L  +  + + +K+ EE  E
Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGE 244

Query: 157 TALAA-TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                     R    +E +DL+YH +VL   QG+ +  V+  LRKR
Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290


>UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU
          Length = 284

 Score =  213 bits (544), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 70/219 (31%), Positives = 112/219 (51%), Gaps = 25/219 (11%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
               L ++   GL+  I Q   +G +LM G+ + +A+  TL + K TF+SR++  LW KG
Sbjct: 46  FLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCKG 104

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD------------------ 107
           ETSGNF+ V S+  DCD D+L+ L  P GPTCH G  +C+                    
Sbjct: 105 ETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRHA 164

Query: 108 TAHQWLFLYQLEQLLAERK----SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-AT 162
                  LY+LE  +  R+    + D + S+T +L  +  + + +K+ EE  E       
Sbjct: 165 AEEALTTLYELEATIEARRVEAVADDVKPSWTRRLLDN-PELLCKKIREEAGELCQTWEE 223

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              +   TNE +D++YH +V+L  QG+ ++ V+  LR+R
Sbjct: 224 NEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262


>UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta
           RepID=HIS2_ARATH
          Length = 281

 Score =  211 bits (537), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 75/220 (34%), Positives = 117/220 (53%), Gaps = 25/220 (11%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            +     + W+   GL   I Q+  +G VLM G++N EAL  T+ S K TFFSR++  LW
Sbjct: 52  VDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTLW 110

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ----- 117
           TKGETS NF+N++ +  DCD D+++ L  P GPTCH G  +C+  +    L   +     
Sbjct: 111 TKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGNK 170

Query: 118 --------LEQLLAERKSADP-----ETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                   LE ++++RK         + S+T +L       +  K+ EE  E     T+ 
Sbjct: 171 LALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADELC--RTLE 227

Query: 165 DRFELT---NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D  E++   +E +D++YH +VLL  +G+ +  V+E LRKR
Sbjct: 228 DNEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267


>UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2
           Tax=Campylobacter RepID=B9D5P8_WOLRE
          Length = 329

 Score =  210 bits (535), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P +VQ + SGEVLML YMN EAL+ +L++G   +FSRTK R+W KGE S
Sbjct: 2   KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107
           GN   +  I  DCDNDT+L+     G   CH G  SCF                      
Sbjct: 62  GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121

Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
                      +  + ++   + +RK +ADP+TSY A L+  G   I +KVGEE  E  +
Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181

Query: 160 AATVHD 165
           A     
Sbjct: 182 ACKDAS 187



 Score = 54.4 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 13/35 (37%), Positives = 18/35 (51%)

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E+  EA+DL +H LV L   G+    V   L +R
Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315


>UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM
           16069 RepID=C7RAI7_KANKD
          Length = 412

 Score =  209 bits (533), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 67/193 (34%), Positives = 102/193 (52%), Gaps = 6/193 (3%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           LD++K   L+P IVQ   +G VLML Y  PE+L   +   K  +FSR++  LW KG TSG
Sbjct: 224 LDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNELWEKGLTSG 282

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           N   +++I  DCD DTL+      G  CH    SCF   +  +  L  L+++  +R  + 
Sbjct: 283 NQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANF-DLDVLDRVFEQRMQSQ 341

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
             TS++ KL AS      +K+ EE  E   A    D+ E+  EA+DL++  L   + +G+
Sbjct: 342 EVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFALARAKSKGV 397

Query: 190 DLTTVIENLRKRH 202
             + +I  L  R+
Sbjct: 398 AASDIINELGARN 410


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  206 bits (524), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 67/203 (33%), Positives = 104/203 (51%), Gaps = 9/203 (4%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT++   E+  ++ DGL   +V        L L Y + +++ K ++ G+  ++SR++  
Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLE 119
           +W KGETSGN   ++ I+ DCD+D L  +        CH  T SCFG+  H  +    LE
Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVG---LE 249

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            LL +R    PE SYT +L+ + +  +  K+ EE  E   A     + EL+ EA+DL Y 
Sbjct: 250 SLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L  L    + L  V  NL  +H
Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  194 bits (494), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 62/189 (32%), Positives = 94/189 (49%), Gaps = 10/189 (5%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           ++ DGL+P +V        L L Y + E++ + L++    + SR +  LW KG TSG+  
Sbjct: 204 DRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGDTQ 261

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            +V I+ DCDND L  +    G  CH   S CFGD       L +LE  L  RK + P  
Sbjct: 262 ELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDLKG----LAKLESTLLSRKQSAPAG 317

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA+L++   K +  K+ EE  E   A   +    +  EA+DL+Y  L      G+ L 
Sbjct: 318 SYTARLFS-DEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVTLA 373

Query: 193 TVIENLRKR 201
            + ++L  +
Sbjct: 374 DIEKSLDAK 382


>UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira
           pseudonana RepID=B8BUA9_THAPS
          Length = 272

 Score =  193 bits (490), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 13/198 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +  ++ DGL   +V    SGE L L Y + E++   L+SG+  ++SR++  LW KG+TSG
Sbjct: 59  VKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSG 117

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
           +F  +  +  DCD D L       G      CH  T +C+G+       L  LE  L +R
Sbjct: 118 HFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEPRG----LRHLEGTLQQR 173

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
               P  SYT +L+      +  K+ EE  E + A     +  +  E +D++Y  +V   
Sbjct: 174 LKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRAA 229

Query: 186 DQGLDLTTVIENLRKRHQ 203
             G+ +   +E L +R +
Sbjct: 230 KAGVSIDDAVEELDRRTR 247


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  192 bits (489), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 66/198 (33%), Positives = 102/198 (51%), Gaps = 17/198 (8%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           ++ DGL   +V     G  L L Y + E++ ++L +G+  + SR +  LW KGE+SG+  
Sbjct: 202 DRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-LWYKGESSGDIQ 259

Query: 73  NVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131
            +VS++ DCD+D L  +    G   CH  T +CFGD    +  L +L++ L  RK + P+
Sbjct: 260 ELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQKTLQSRKESAPQ 315

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            SYTA+L+ +  + +  K+ EE  E   A T   +  +  EA+DL Y  L      G+ L
Sbjct: 316 GSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFALTKCVAAGVSL 371

Query: 192 TTVIENLR------KRHQ 203
             V  NL       KR Q
Sbjct: 372 EDVERNLDAKSIKVKRRQ 389


>UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira
           RepID=B5VZW9_SPIMA
          Length = 200

 Score =  188 bits (478), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 58/200 (29%), Positives = 95/200 (47%), Gaps = 18/200 (9%)

Query: 6   QRRELDWEKTD--GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
              ++D  + D  GL+ + +Q  ++G VL LG MN EAL KTL + ++ +  +++  LW 
Sbjct: 17  NLIDIDKIRYDDQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWH 76

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
                   + + SI+ D   + L+         C    +   G T      L  L +++ 
Sbjct: 77  P------DIILESISYDYRGNFLVAGV----AYCPSELNGSGGHT------LAGLFRVIC 120

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +R+      SYT +L+A G  +I +K+GEE  E  +A    +   + +E +DL YH LV 
Sbjct: 121 DRRDHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVA 180

Query: 184 LQDQGLDLTTVIENLRKRHQ 203
           L    +DL  V E L  R Q
Sbjct: 181 LAYHQVDLRKVYEQLEARRQ 200


>UniRef50_A0YJX3 Phosphoribosyl-ATP
           pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase
           n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN
          Length = 198

 Score =  186 bits (474), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 53/190 (27%), Positives = 87/190 (45%), Gaps = 12/190 (6%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P I+Q  + G VL L +M+ ++L KT E  +V     +   L +    +G   +
Sbjct: 21  NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLLITGWRYD 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
                P C +  +LV    I    ++     F   +   L   ++ +++ +R+    E S
Sbjct: 81  -----PACQSLLILVECGSIAEPQNE-----FAQVSSNLL--SEVFEVICDRRDHPQEDS 128

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193
           YT KL A G  +I +K+GEE  E  +A    D   + +E +DL YH LV +     DL  
Sbjct: 129 YTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAYHRADLRQ 188

Query: 194 VIENLRKRHQ 203
           V   L +R +
Sbjct: 189 VYRKLAERRR 198


>UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces
           RepID=HIS2_SCHPO
          Length = 417

 Score =  186 bits (473), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 63/203 (31%), Positives = 102/203 (50%), Gaps = 11/203 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L +      + ++ DGL   +V + + G  L L Y + E++ ++L++G   + SR +  L
Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KG +SG   +++ I  DCD D L  +    G   CH  T  CFG  +     L QLE+
Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASG----LCQLEK 308

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L +RK+  PE SYTA+L++   K +  K+ EE  E   A T   +  +  E +DLMY  
Sbjct: 309 TLIDRKNNAPEGSYTARLFS-DPKLLRAKIMEEAEELCDATT---KENVIWEMADLMYFA 364

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +      G+ L  +  +L  +H+
Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  184 bits (467), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 61/208 (29%), Positives = 94/208 (45%), Gaps = 13/208 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L  ++TDGL    V  +     L L Y +P ++ K++ +G   + SR +  L
Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CH-KGTSSCFGDTAHQWLFL 115
           W KGE+SG    VVSI  DCD+D +         T     CH +    CF         L
Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSATG----L 307

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            +LE  L  R    P  SYTA+L+ +    +  K+ EE  E A A   +D+  +  EA+D
Sbjct: 308 AKLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAAD 365

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+Y  L      G+ L  +  +L  + +
Sbjct: 366 LIYFALTKCVSAGIGLEEIEASLDAKAK 393


>UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4CVB3_9BACT
          Length = 128

 Score =  173 bits (439), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 51/123 (41%), Positives = 70/123 (56%), Gaps = 4/123 (3%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P IVQ   +  VLM+ +MN  +L+ TL++G + ++SR++Q+ W KGETSG+   V
Sbjct: 10  ADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGETSGHTQKV 69

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134
           V  A DCD DTLL     IG  CH G  SCF           +    + E K  DPE +Y
Sbjct: 70  VRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSPEGTPLE----ITEEKLFDPEKTY 125

Query: 135 TAK 137
            +K
Sbjct: 126 ASK 128


>UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN
          Length = 477

 Score =  173 bits (438), Expect = 5e-42,   Method: Composition-based stats.
 Identities = 59/193 (30%), Positives = 90/193 (46%), Gaps = 10/193 (5%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           L  ++ D L   +V    +G  L L Y + E++   + SG+  ++SR++  LW KGE+SG
Sbjct: 249 LRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKKGESSG 307

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           N   ++ I  DCD+D L    N  G   CH  T +C+G        L  LE +L  R   
Sbjct: 308 NAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHDGG----LRALESMLFSRHEN 363

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
            P  SYT +L+    + +  K+     E    A      ++  EA+D+MY  +V     G
Sbjct: 364 APAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVRCVAAG 419

Query: 189 LDLTTVIENLRKR 201
             L+ V   L KR
Sbjct: 420 CKLSDVERMLDKR 432


>UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_STRTD
          Length = 112

 Score =  170 bits (432), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 47/103 (45%), Positives = 65/103 (63%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD++K  GL+PVIV    +G+VLML YMN  +   TLE+ ++ ++SR++  LW KG TS
Sbjct: 5   KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111
           G+F +V SI  DCD DTLL+     G  CH G  SCF    + 
Sbjct: 65  GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYD 107


>UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=C4XTP1_DESMR
          Length = 124

 Score =  167 bits (424), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 54/99 (54%), Positives = 67/99 (67%), Gaps = 1/99 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           D+ K  GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+
Sbjct: 5   DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT 108
              V S+  DCD DT+LVL   I G  CH+G  SCF   
Sbjct: 65  VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFFTE 103


>UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT
          Length = 116

 Score =  166 bits (422), Expect = 3e-40,   Method: Composition-based stats.
 Identities = 41/106 (38%), Positives = 61/106 (57%), Gaps = 2/106 (1%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
            +L +   D L+P I Q    G VLM+ +MN E++ KTL +G+  ++SR++ +LW KG T
Sbjct: 9   EKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKGAT 67

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112
           SG+   V  +  DCD DT+L+    IG   CH G  SCF +    +
Sbjct: 68  SGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113


>UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms
           RepID=HIS3_SOLUE
          Length = 126

 Score =  166 bits (421), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 7/130 (5%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            LD+ K+DGL+  ++Q   SG VLM+GYMN EA +KT+E+G  TF+SR++++LW KGE+S
Sbjct: 2   NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           G+ L V  I+ DCD D +LV     GP  CH+G  SCF         L   E  +A+  +
Sbjct: 62  GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFR------RLDAGEWKVADNPT 115

Query: 128 ADPETSYTAK 137
            DP   Y  K
Sbjct: 116 YDPGAVYGGK 125


>UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms
           RepID=HIS3_PELLD
          Length = 137

 Score =  166 bits (420), Expect = 5e-40,   Method: Composition-based stats.
 Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 6/133 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + ++   GL+P IVQ   +G+VLM+ +MN E+L+ TLE  K  ++SR++ +LW K
Sbjct: 10  SFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SGN  +V  I  DCD DTL++  + IG  CH G  SCF     +   +      + +
Sbjct: 69  GESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYRRVLENGNME-----ICD 123

Query: 125 RKSADPETSYTAK 137
               DPE  Y  K
Sbjct: 124 TLMFDPEEVYGKK 136


>UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F746
          Length = 123

 Score =  166 bits (420), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 48/103 (46%), Positives = 67/103 (65%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T +  REL    +DGL+PVIVQ   + EVLM+ +M+ EA+++TL +G   ++SR++Q  W
Sbjct: 13  TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            KGETSGN   V S++ DCD D LL+     GP CH  T +CF
Sbjct: 73  VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCF 115


>UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae
           RepID=HIS3_FRAAA
          Length = 132

 Score =  164 bits (417), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 46/89 (51%), Positives = 62/89 (69%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL P I Q   +GEVLMLG+M+ EAL +TL +G+ T++SR++   W KG+TSG+   V S
Sbjct: 22  GLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQWVRS 81

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +A DCD D +LV  + IGP CH GT +CF
Sbjct: 82  VALDCDGDAVLVRVDQIGPACHTGTRNCF 110


>UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota
           RepID=HIS3_HALWD
          Length = 132

 Score =  164 bits (417), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 54/126 (42%), Positives = 74/126 (58%), Gaps = 10/126 (7%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           E+ +  +DGL+P I Q A SGEVLML Y++P AL +T E+G+  ++SR+++ LW KGETS
Sbjct: 16  EIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWKKGETS 74

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           G+  ++  I  DCD DT+L L    G  CH G  SCF  T         L+      +  
Sbjct: 75  GHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRT---------LDGTEVTERVF 125

Query: 129 DPETSY 134
           DPET Y
Sbjct: 126 DPETVY 131


>UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria
           RepID=B8J3P0_DESDA
          Length = 137

 Score =  164 bits (416), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 45/99 (45%), Positives = 66/99 (66%), Gaps = 3/99 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           D+ K  GL+P I Q   SGEVLML YMN EA  KTLE+G+  ++SR+++++W KG TSG+
Sbjct: 19  DFSK--GLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGTSGH 76

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT 108
              V+++  DCD+DT+L+  + + G  CH G  +CF   
Sbjct: 77  IQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE 115


>UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria
           RepID=HIS3_THICR
          Length = 147

 Score =  164 bits (415), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 48/126 (38%), Positives = 66/126 (52%), Gaps = 8/126 (6%)

Query: 5   QQRRELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           QQ    DWE          +GL+P I Q   S EVLM+ +MN  AL +TLE+G+V ++SR
Sbjct: 14  QQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSR 73

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLY 116
           ++Q  W KGE SG    +  +  DCD D +L+L +  GP CH G  SCF    H      
Sbjct: 74  SRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKI 133

Query: 117 QLEQLL 122
               ++
Sbjct: 134 LTNPII 139


>UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales
           RepID=C4Z0A8_EUBE2
          Length = 362

 Score =  164 bits (415), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 50/98 (51%), Positives = 66/98 (67%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GL+PV+VQ  V+ EVLML YMN EA +KTLE+G +T++SR++Q LW KG TSG+F  V
Sbjct: 263 ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQELWVKGLTSGHFQYV 322

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112
            S+  DCDNDT+L     +G  CH G  +CF      W
Sbjct: 323 GSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTW 360


>UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae
           RepID=HIS3_ACIC1
          Length = 142

 Score =  163 bits (414), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 45/89 (50%), Positives = 62/89 (69%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL P + Q   +GEVLM+G+M+ EAL +TL +G+ T++SR++Q  W KGETSG+   V S
Sbjct: 22  GLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQWVKS 81

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +A DCD DT+LV  + IG  CH G  +CF
Sbjct: 82  VALDCDGDTVLVKVDQIGAACHTGDRTCF 110


>UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria
           RepID=HIS3_DINSH
          Length = 119

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 44/106 (41%), Positives = 65/106 (61%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q  W KGE+SG+   +V 
Sbjct: 14  GLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGESSGHVQTLVE 73

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           +  DCD D LL+     GP CH    +CF         +  +  ++
Sbjct: 74  MRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119


>UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria
           RepID=A4GIE4_9BACT
          Length = 132

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 42/105 (40%), Positives = 67/105 (63%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q   +GEVLM+ +MN  +L +TL +G++ ++SR+++ LW KG+TSG+   +
Sbjct: 15  ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           + +  DCD D++LVL +  G  CH+GT SCF         + + E
Sbjct: 75  IELRYDCDADSILVLVDQSGAACHEGTRSCFTRRLEIDGSISEAE 119


>UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria
           RepID=HIS3_CORJK
          Length = 127

 Score =  163 bits (413), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 42/92 (45%), Positives = 57/92 (61%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             DGL+P IVQ   +G+VLM+ +MN  AL  TL + K T++SR++Q  W KGETSG+   
Sbjct: 30  NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSYWIKGETSGHTQR 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           V  +  DCD DT+L+     G  CH G  +CF
Sbjct: 90  VEEVRLDCDGDTVLLKIEQTGAACHTGNRTCF 121


>UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured
           crenarchaeote RepID=Q702A1_9CREN
          Length = 115

 Score =  163 bits (412), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 42/104 (40%), Positives = 65/104 (62%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   +LD+ K DGL+PV+VQ   + ++LML Y N  A++ T+++G   F+S ++ +LW 
Sbjct: 7   DEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWM 66

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107
           KGE SGN   V  I  DCD D++L L +   P CH G  +CF +
Sbjct: 67  KGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHN 110


>UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3
          Length = 140

 Score =  162 bits (411), Expect = 5e-39,   Method: Composition-based stats.
 Identities = 48/125 (38%), Positives = 69/125 (55%), Gaps = 5/125 (4%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + ++K +GL+P I Q   +G+VLML YMN E+L+ TL+  K  ++SR++Q LW KG TSG
Sbjct: 15  VRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLKGATSG 73

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           NF  V+ I+ DCD D +L+     G  CH G  SCF                + ++   D
Sbjct: 74  NFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVENDNSSLS----ICDKLVFD 129

Query: 130 PETSY 134
            E  Y
Sbjct: 130 AEEVY 134


>UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R0U5_9PLAN
          Length = 310

 Score =  162 bits (411), Expect = 6e-39,   Method: Composition-based stats.
 Identities = 41/125 (32%), Positives = 68/125 (54%), Gaps = 1/125 (0%)

Query: 11  DWEKTD-GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           D+ + +  L+P I Q   +GEVLM+ +MN E+  +T+ +G+  ++SR++ +LW KGE SG
Sbjct: 173 DFSRGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESG 232

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           +   V  +  DCD DT+L+  + +G  CH+G  SCF             E+L+       
Sbjct: 233 HMQTVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYK 292

Query: 130 PETSY 134
              S+
Sbjct: 293 NPKSH 297


>UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268
           RepID=C8PI34_9PROT
          Length = 336

 Score =  161 bits (409), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 51/101 (50%), Positives = 61/101 (60%), Gaps = 1/101 (0%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P IVQ A  G VLML YMN EAL  TL +G   +FSR+K R+W KGE S
Sbjct: 2   KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDT 108
           G+   V S   DCDND LL+     G   CH G  SCF   
Sbjct: 62  GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKE 102



 Score = 69.1 bits (168), Expect = 8e-11,   Method: Composition-based stats.
 Identities = 28/132 (21%), Positives = 49/132 (37%), Gaps = 24/132 (18%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVG 151
                +    +        +  L ++  +  +RK + +P  SY A LYA G     +K+ 
Sbjct: 194 DAAAQNSTLENSA--EKGPYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251

Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190
           EE  E ALA     R EL  + +              D++Y        LL+ L    + 
Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311

Query: 191 LTTVIENLRKRH 202
              +++ L +R 
Sbjct: 312 PDALLDELARRQ 323


>UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria
           RepID=HIS3_BURS3
          Length = 138

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 47/132 (35%), Positives = 73/132 (55%), Gaps = 10/132 (7%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ W+  +GL+PVI Q A + +VLM  +MN EAL KT+E+ +  ++SR+++RLW KGE
Sbjct: 12  LDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWFKGE 70

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCF---GDTAHQWLFLYQLEQLL 122
            SG+  +V  +  DCD D +L+    + G  CH G  SCF    +          +E +L
Sbjct: 71  ESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVEPVL 130

Query: 123 AERKSADPETSY 134
            +     PE  Y
Sbjct: 131 KD-----PEHIY 137


>UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria
           RepID=HIS3_SILST
          Length = 129

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 43/92 (46%), Positives = 60/92 (65%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+P I Q   SGE+LM+ +MN E++ KTLE+G+VT++SR++Q  W KGE+SG+   +V 
Sbjct: 24  GLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQELVE 83

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           +  DCD D LL +    GP CH    SCF   
Sbjct: 84  LRVDCDRDALLAMVRQTGPACHTNRRSCFYTA 115


>UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_CHLP8
          Length = 137

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +     + ++   GL+P IVQ   +G+VLM+ +MN E+L  TLE  K  ++SR++ +LW 
Sbjct: 9   KSFLETVKFDDR-GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE+SGN  +V  I  DCD DTLL+  +  G  CH G  SCF         +      + 
Sbjct: 68  KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQME-----IC 122

Query: 124 ERKSADPETSYTAK 137
           +    DPE  Y  K
Sbjct: 123 DTLMFDPEEVYGKK 136


>UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class)
           RepID=HIS3_CLAMS
          Length = 138

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 50/118 (42%), Positives = 70/118 (59%), Gaps = 8/118 (6%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P ++Q   + EVLMLGYM+ EAL +TL +G+VTF+SR++   W KG+TSG+   V 
Sbjct: 28  DGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYWRKGDTSGHGQYVR 87

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
             A DCD DT+LV  + +G  CH GT +CF            L  +   R +AD   +
Sbjct: 88  DAALDCDGDTVLVQVDQVGVACHTGTRTCF--------DADHLHPVTGARPAADEGPT 137


>UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC
           49814 RepID=C6XNB8_HIRBI
          Length = 139

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 41/94 (43%), Positives = 57/94 (60%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+  I Q   S EVLML +MN +AL  T+E+G+  ++SR++ +LW KG+TSG +  
Sbjct: 30  NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107
           V SI  DCD D +L+        CH G  SCF  
Sbjct: 90  VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYR 123


>UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria
           RepID=Q2SLC2_HAHCH
          Length = 139

 Score =  160 bits (406), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 45/103 (43%), Positives = 66/103 (64%), Gaps = 1/103 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                EL +    GL+PVI Q A +  +LM  +MN EAL+KT+ + ++T++SR++QRLW 
Sbjct: 21  PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           KGETSG+   +VS++ DCD D +L L +  G  CH G  +CF 
Sbjct: 80  KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFY 122


>UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_RALEJ
          Length = 135

 Score =  160 bits (405), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 49/140 (35%), Positives = 76/140 (54%), Gaps = 10/140 (7%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   ++ W+  +GL+PVIVQ   + +VLM  +MN +AL KT E G+  F+SR+++RL
Sbjct: 1   MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCF---GDTAHQWLFLYQ 117
           W KGE SG+   V  +  DCD D +L+    +    CH G  SCF    +   +      
Sbjct: 60  WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEGDAESGDWQT 119

Query: 118 LEQLLAERKSADPETSYTAK 137
           +E +L +     P   YTAK
Sbjct: 120 VEPVLKD-----PSQIYTAK 134


>UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_GEOSF
          Length = 126

 Score =  159 bits (404), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 48/127 (37%), Positives = 71/127 (55%), Gaps = 7/127 (5%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   SGEVLM+ +M+ + LD TL+ GK  FFSRT+ + W KGE S
Sbjct: 3   KIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGEES 62

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           GN   V+ +  DCD DT+++     GP  CH G  SCF      ++     + +      
Sbjct: 63  GNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCF------YVKWEDGQWVEHSNPL 116

Query: 128 ADPETSY 134
            DP   Y
Sbjct: 117 FDPNEVY 123


>UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM
          Length = 151

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 45/105 (42%), Positives = 60/105 (57%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P + Q A +G+VLML +MN  A++KTLE+G++T+FSR++  LW KG  SGN   
Sbjct: 41  NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVKGLASGNHQQ 100

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           +V    DCD D LL      G  CH G  SCF   A+       L
Sbjct: 101 LVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145


>UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria
           RepID=HIS3_SALRD
          Length = 127

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 44/106 (41%), Positives = 63/106 (59%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+P IVQ A + +VLM+ YM  E L +TL++G++ ++SR++Q  W KG+TSG+   V 
Sbjct: 14  DGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQERWVKGQTSGHTQTVE 73

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
               DCD DTLL   +  G  CH G  SCF   A    +    E++
Sbjct: 74  EARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAADDGWTTDGEKV 119


>UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_RHOPS
          Length = 147

 Score =  159 bits (402), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 45/118 (38%), Positives = 67/118 (56%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  +   A SGEVLM+ +MN EAL+KT++SG+  ++SR+++RLW KGE+SG+   V+ 
Sbjct: 28  GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGHVQRVLE 87

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134
           I  DCD D + +     G  CH G  SCF     +      L  ++   +  DP   Y
Sbjct: 88  IRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTMVDADRLFDPAKIY 145


>UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca
           ATCC 27029 RepID=D1SGQ9_9ACTO
          Length = 444

 Score =  159 bits (402), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 43/96 (44%), Positives = 59/96 (61%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+  +V+   SGEVLM+ +M+ EAL +TL +G+ T++SR++   W KG TSGN   V
Sbjct: 341 PDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQYV 400

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH 110
            S+A DCD D LLV    +G  CH G  +CF     
Sbjct: 401 RSVALDCDGDALLVSVEQVGAACHTGQRTCFFTELP 436


>UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria
           RepID=HIS3_RHOPT
          Length = 151

 Score =  159 bits (402), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 47/122 (38%), Positives = 72/122 (59%), Gaps = 3/122 (2%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
             GL+ V+   A +G+VLM+ +MN EALD+T+++G+  ++SR+++RLW KGETSG+   V
Sbjct: 29  AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGHIQKV 88

Query: 75  VSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLF-LYQLEQLLAERKSADPET 132
           + +  DCD D + +  +   G  CH G  SCF     +       L +  AERK  DP+ 
Sbjct: 89  LEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLIETDAERK-FDPDK 147

Query: 133 SY 134
            Y
Sbjct: 148 VY 149


>UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria
           RepID=HIS3_BIFLI
          Length = 136

 Score =  159 bits (402), Expect = 7e-38,   Method: Composition-based stats.
 Identities = 44/101 (43%), Positives = 63/101 (62%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  ++Q   + EVLM+GYMN EAL +TL +G+VTF+SR++Q  W KG+TSG+   V  
Sbjct: 26  GLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQYVKG 85

Query: 77  IAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
           ++ DCD D LLV  + +G  CH G  SCF +     +    
Sbjct: 86  VSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 126


>UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_METTH
          Length = 138

 Score =  158 bits (401), Expect = 8e-38,   Method: Composition-based stats.
 Identities = 44/128 (34%), Positives = 68/128 (53%), Gaps = 7/128 (5%)

Query: 10  LDWEKT-DG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
           L++    +G  L+  + Q   +GEVLM+ YMN EAL +TLE+G   ++S ++ +LW KGE
Sbjct: 12  LNFRHNINGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGE 71

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SG+   V  +  DCD D +++     G  CH G  SCF  +        + + +    K
Sbjct: 72  SSGHVQRVKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----K 127

Query: 127 SADPETSY 134
             DPE  Y
Sbjct: 128 VFDPEEIY 135


>UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA
          Length = 126

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 42/106 (39%), Positives = 60/106 (56%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P I Q A +G VLML +MN EA D+T+   +  +FSR++ +LW KG+TSG+   V  I
Sbjct: 21  LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
             DCD DT+L+     G  CH+   SCF          +  E+ +A
Sbjct: 81  RVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERIA 126


>UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria
           RepID=HIS3_ACIAC
          Length = 141

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 52/132 (39%), Positives = 71/132 (53%), Gaps = 11/132 (8%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             E+ W+   GL+PVI Q A +G+VLM  +MN EAL KT E G+  +FSR++ RLW KGE
Sbjct: 16  LDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFKGE 74

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
            SG+   V  I  DCDND +L+    +    G  CH G  SCF            ++ +L
Sbjct: 75  ESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSVLKDGA-WQAVDPVL 133

Query: 123 AERKSADPETSY 134
            +     PE+ Y
Sbjct: 134 KD-----PESIY 140


>UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium
           HTCC2255 RepID=Q0FGM5_9RHOB
          Length = 120

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 42/105 (40%), Positives = 62/105 (59%), Gaps = 1/105 (0%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            L ++  +GL+P +VQ   + EVLM+ +MN  +L+KT E+   TF+SR+++ LW KG TS
Sbjct: 8   SLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGLTS 66

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           GN   V  +  DCD D +L+L  P GP CH    +CF     +  
Sbjct: 67  GNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTELEEGS 111


>UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium
           amycolatum SK46 RepID=UPI000185C2AA
          Length = 132

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 41/92 (44%), Positives = 58/92 (63%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             DGL+P IVQ   +G VLM+ +M+  AL  T+ + + T++SR++   W KG TSG+F  
Sbjct: 33  NADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWIKGLTSGHFQT 92

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           V S+A DCD DT+L+     G  CH G+ SCF
Sbjct: 93  VTSLALDCDGDTVLMQVVQDGAACHTGSHSCF 124


>UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_PSEU2
          Length = 130

 Score =  157 bits (398), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 41/127 (32%), Positives = 67/127 (52%), Gaps = 3/127 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             E+ W  +DGL+P I Q   +G VLM+ +MN EAL  T    +  ++SR++ +LW KGE
Sbjct: 5   LDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWRKGE 63

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
            SG+   +  +  DCD D ++++   IG   CH G  SCF    ++      ++ +L + 
Sbjct: 64  ESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYR-VYEKSGWKTVDPVLKDP 122

Query: 126 KSADPET 132
            +  P  
Sbjct: 123 DAIYPAG 129


>UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides
           RepID=Q03VY1_LEUMM
          Length = 132

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 48/118 (40%), Positives = 67/118 (56%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
            + + +  +GL+P ++  A +   LMLGYMN E+   T  +G+  F+SR +Q LW KGET
Sbjct: 6   PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQELWHKGET 65

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
           SGN   VVS+  DCD DTLL+  NP GP CH    SCF +T          +  +A +
Sbjct: 66  SGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQATIANK 123


>UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii
           'Deep ecotype' RepID=B4RV64_ALTMD
          Length = 133

 Score =  156 bits (394), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 46/103 (44%), Positives = 67/103 (65%), Gaps = 1/103 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   EL+++  DGL+PVI Q   S +VLM  +M+ E+LD+TL +GK+ ++SR++Q LW 
Sbjct: 20  DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           KG +SG+   V SIA DCD D LL   + +G  CH    SCF 
Sbjct: 79  KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFY 121


>UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae
           RepID=HIS3_METS3
          Length = 132

 Score =  156 bits (394), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 43/134 (32%), Positives = 69/134 (51%), Gaps = 9/134 (6%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
             R E++ +K    +  I Q   +G++LM+  MN +AL KT+E+GK  ++S ++   W K
Sbjct: 4   NFRHEINGQKV---ITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH----QWLFLYQLEQ 120
           GE+SG+   V  I  DCD D +++     G  CH+G  SCF    +    +      LE 
Sbjct: 61  GESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLET 120

Query: 121 LLAERKSADPETSY 134
           +L   K  +P+  Y
Sbjct: 121 ILE--KVFNPDDVY 132


>UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria
           RepID=HIS3_CHRSD
          Length = 146

 Score =  155 bits (393), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 45/104 (43%), Positives = 62/104 (59%), Gaps = 1/104 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T        W    GL+P I Q   SGEVLM+ +MN  AL++TL +G+V ++SR++ + W
Sbjct: 19  TRDLLDAARWNDA-GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
            KGE+SG    +V+   DCD DTLL+  +  GP CH G  SCF 
Sbjct: 78  RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFY 121


>UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria
           RepID=HIS3_BACCN
          Length = 101

 Score =  153 bits (387), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 44/98 (44%), Positives = 63/98 (64%), Gaps = 2/98 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           ++ K  GL+P IV +  + EVLML YMN EA +KTL++ K  F+SR++Q LW KG TSG+
Sbjct: 4   NFSK--GLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGH 61

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
             +V S+  DCD D +++  N +G  CH G  +CF   
Sbjct: 62  VQHVKSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99


>UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria
           RepID=C7RQA3_9PROT
          Length = 142

 Score =  153 bits (387), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 1/111 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +   EL +++  GL+  I Q   + E+LML +MN  A+++TL +G   ++SR+++ +W K
Sbjct: 18  EVLDELAFDQQ-GLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL 115
           GETSG    V+    DCD D +L+L + +G  CH G SSCF +        
Sbjct: 77  GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRNGRVE 127


>UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms
           RepID=C7NRL7_HALUD
          Length = 138

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 43/102 (42%), Positives = 59/102 (57%)

Query: 19  MPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIA 78
           +P + Q A SG+VLML Y+  EALD+T E+G   ++SR++  LW KGETSGN  ++  I 
Sbjct: 31  LPAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETSGNVQHLKEIR 90

Query: 79  PDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
            DCD D LL +    G  CH G  SCF  T    +   ++  
Sbjct: 91  VDCDGDALLYVIEQDGGACHTGFQSCFHRTIDGEVVGERVFD 132


>UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae
           RepID=HIS3_GLUOX
          Length = 156

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 40/106 (37%), Positives = 65/106 (61%), Gaps = 2/106 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +    ++ ++  +GL+  + Q A  G VLML +MN +AL +TL +G+V ++SR++Q+L
Sbjct: 30  IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107
           W KGETSG    ++    DCD D +L++ +  G  CH G  SCF  
Sbjct: 88  WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYH 133


>UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales
           RepID=HIS3_MYCBP
          Length = 115

 Score =  152 bits (384), Expect = 9e-36,   Method: Composition-based stats.
 Identities = 40/93 (43%), Positives = 60/93 (64%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
              DGL+  +VQ   SG+VLM+ +MN EAL +TL++ + T++SR++   W KG TSG+  
Sbjct: 13  RNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQWVKGATSGHTQ 72

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           +V S+  DCD D +L+  + +G  CH G  SCF
Sbjct: 73  HVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCF 105


>UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria
           RepID=B9QYY7_9RHOB
          Length = 159

 Score =  151 bits (383), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 48/122 (39%), Positives = 67/122 (54%), Gaps = 4/122 (3%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           DGL+  +V    + EVLM+GYMN EAL +T+E+G+  ++SR+++  W KGETSG    V 
Sbjct: 36  DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQIQKVQ 95

Query: 76  SIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDT-AHQWLFLYQLEQLLAERKSADPET 132
            I  DCD D L+V       G TCH G  SCF     +      +L  +  + K  DP+ 
Sbjct: 96  EILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANV-EKEKVYDPKK 154

Query: 133 SY 134
            Y
Sbjct: 155 VY 156


>UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales
           RepID=HIS3_RHISN
          Length = 152

 Score =  151 bits (382), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 46/123 (37%), Positives = 64/123 (52%), Gaps = 3/123 (2%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+  +V  A  GE+LM+ +MN EAL  T+E+G   ++SR++  LW KGE+SGN   V  
Sbjct: 29  GLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGNTQAVQE 88

Query: 77  IAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134
           I  DCD D + +     G   TCH G  SCF  T        ++  +  E +  DP   Y
Sbjct: 89  IRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARV-TITDEHRHFDPAQIY 147

Query: 135 TAK 137
             K
Sbjct: 148 AEK 150


>UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales
           RepID=HIS3_ERYLH
          Length = 125

 Score =  150 bits (380), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 47/107 (43%), Positives = 65/107 (60%), Gaps = 4/107 (3%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+  +VQH  + EVLM+ +MN +ALD T ++G   FFSR++Q LW KG TSGN L V
Sbjct: 21  SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAV 80

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
             +  DCD D +++L  P GP CH G  +CF       L    L+ +
Sbjct: 81  SQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE----LDCGALQDV 123


>UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae
           RepID=HIS3_PYRCJ
          Length = 128

 Score =  150 bits (380), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 39/102 (38%), Positives = 61/102 (59%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
           + L++    G +  +VQ   +GEVLM+G+M+P A+  TL +G   ++S +++R+W KGET
Sbjct: 17  KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
           SG++  V     DCD D +++    IG  CH G  SCF   A
Sbjct: 77  SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSPA 118


>UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P0M4_9BACE
          Length = 108

 Score =  150 bits (380), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 50/97 (51%), Positives = 71/97 (73%), Gaps = 1/97 (1%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           ++K++ L+PVI+Q A + EVLMLG+ N EA++ TL++    F+SR++Q+LW KGETSG+F
Sbjct: 8   FQKSE-LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHF 66

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           L+V  +  DCD DTLL   +P+GPTCH G  SCF   
Sbjct: 67  LHVERMVTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103


>UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_MESSB
          Length = 139

 Score =  150 bits (379), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 45/96 (46%), Positives = 59/96 (61%), Gaps = 2/96 (2%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GL+  +V  A  G +LM+ +MN EAL KTLE+G   ++SR++  LW KGETSGN  +V
Sbjct: 30  ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGNLQHV 89

Query: 75  VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDT 108
            SI+ DCD D +L  V     G TCH G  SCF   
Sbjct: 90  ESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRN 125


>UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13
           RepID=B6BVA2_9PROT
          Length = 129

 Score =  150 bits (379), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 50/122 (40%), Positives = 76/122 (62%), Gaps = 3/122 (2%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               ++ W    GL+P I+Q   S +V+M+ +MN EAL KT+E+ +  F+SR++ ++W K
Sbjct: 2   NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDT-AHQWLFLYQLEQLL 122
           GE SGNF NVVSI  DCD D+LLV  N   G +CH G +SCF +  +     +  +E++L
Sbjct: 61  GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120

Query: 123 AE 124
            +
Sbjct: 121 KD 122


>UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ
          Length = 149

 Score =  149 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 43/95 (45%), Positives = 58/95 (61%), Gaps = 2/95 (2%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+P IV  A SG VLM  +MN +AL +T+ +G   F+SR++ +LW KGE SGN L+V
Sbjct: 29  SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88

Query: 75  VSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGD 107
             +  DCD D + +L      G  CH G  SCF  
Sbjct: 89  KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR 123


>UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RPU9_FIBSS
          Length = 116

 Score =  149 bits (376), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 51/116 (43%), Positives = 68/116 (58%), Gaps = 5/116 (4%)

Query: 1   MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57
           M  E   +E+ +E   G   L P IVQ A  G+VLM+ +MN EAL +T E G++ F+SR+
Sbjct: 1   MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60

Query: 58  KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111
           ++  W KG+TSGN + VV  A DCD+D LL      GP   CH G  SCF  T  +
Sbjct: 61  RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116


>UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G191_ABIDE
          Length = 295

 Score =  149 bits (376), Expect = 7e-35,   Method: Composition-based stats.
 Identities = 48/102 (47%), Positives = 64/102 (62%), Gaps = 1/102 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+P IVQ   +G VL + YMN E+L+ TL      F+SR+++ LW KGE
Sbjct: 18  IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           TSGN+ +VVSI  DCD D LLV     G  CH+G  SCF DT
Sbjct: 77  TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDT 118


>UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R0N1_9RHOB
          Length = 156

 Score =  148 bits (375), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 47/138 (34%), Positives = 69/138 (50%), Gaps = 5/138 (3%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L ++   + D    +GL+   V    SGE+LM+GYMN E+L +T+E+G+  ++SR++Q  
Sbjct: 21  LGDELCPKFD---ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           W KG TSG    V+ I  DCD D +   V  +  G TCH G  SCF    +         
Sbjct: 78  WKKGGTSGQVQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWL 137

Query: 120 QLLAERKSADPETSYTAK 137
           +        DP+  Y  K
Sbjct: 138 EKTEVAPVYDPQEVYGKK 155


>UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41B27
          Length = 137

 Score =  148 bits (375), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 40/119 (33%), Positives = 66/119 (55%), Gaps = 3/119 (2%)

Query: 9   ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           EL++    G   L+  + Q   + +VLM+ +MN EA+++TL++ K  ++S ++Q+ W KG
Sbjct: 2   ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           E+SGN   V  +  DCD D +++  + IG  CH+G  SCF            L+ L  E
Sbjct: 62  ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDE 120


>UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI
          Length = 161

 Score =  148 bits (373), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 48/128 (37%), Positives = 69/128 (53%), Gaps = 7/128 (5%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
           +GL+PV+   A +GEVLM  YMN EAL KT+E+G+  ++SR++Q+LW KG++SG    V 
Sbjct: 27  NGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGLVQKVQ 86

Query: 76  SIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQW-LFLYQLEQL----LAERKSA 128
            +A D D D L +       G +CH G  SCF          +   E +        K+ 
Sbjct: 87  QLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTETEKTF 146

Query: 129 DPETSYTA 136
           DP+T Y  
Sbjct: 147 DPKTVYGN 154


>UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter
           necessarius RepID=B1XSV4_POLNS
          Length = 140

 Score =  147 bits (372), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 42/101 (41%), Positives = 60/101 (59%), Gaps = 2/101 (1%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + W    GL+PVI Q   S ++LM+ +MN +AL +TL  G+  +++R++Q+LW KGE
Sbjct: 23  LDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHKGE 81

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106
            SG+   V  I  DCD DT+L+L     G  CH G  SCF 
Sbjct: 82  ESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122


>UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1
           RepID=A3WCC9_9SPHN
          Length = 143

 Score =  145 bits (367), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 47/94 (50%), Positives = 63/94 (67%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
             GL+  +V  + + EVL++ +MN +AL KT E+GKV F+SR++  LW KGETSGN L+V
Sbjct: 35  ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGNVLSV 94

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
             I  DCD D L++ A P GPTCH G +SCF   
Sbjct: 95  DEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128


>UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris
           BL2 RepID=B8EQR3_METSB
          Length = 141

 Score =  144 bits (365), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 42/95 (44%), Positives = 55/95 (57%), Gaps = 2/95 (2%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+  + + A  GE+LM+ YMN EAL  TL +G+  ++SR++Q +W KG TSG    V
Sbjct: 30  PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89

Query: 75  VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGD 107
             I  DCD D LL  + A   G  CH G  SCF  
Sbjct: 90  REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYR 124


>UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae
           RepID=HIS3_ZYMMO
          Length = 124

 Score =  143 bits (361), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 36/100 (36%), Positives = 61/100 (61%), Gaps = 1/100 (1%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           W+   GL+  ++  A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ 
Sbjct: 15  WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111
           + +  I  DCD DTL +   P+GP CH G  SCF      
Sbjct: 74  MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVED 113


>UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI0001910D6A
          Length = 157

 Score =  141 bits (355), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 74/81 (91%), Positives = 77/81 (95%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR
Sbjct: 77  MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136

Query: 61  LWTKGETSGNFLNVVSIAPDC 81
           LWTKGETSG+ LNVVSIAPDC
Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157


>UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001744401
          Length = 141

 Score =  141 bits (355), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 35/97 (36%), Positives = 52/97 (53%), Gaps = 1/97 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I     + E LM+ YMN E L  T+  G+  ++SR+++ +W KG+TSG F  V
Sbjct: 31  ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGEFQVV 90

Query: 75  VSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAH 110
             I  DCD D +++    +G   CH    +CF     
Sbjct: 91  KEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRKVD 127


>UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/
           phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus
           Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT
          Length = 127

 Score =  140 bits (353), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 45/130 (34%), Positives = 67/130 (51%), Gaps = 5/130 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           Q   +L +    GL+P ++  A  G+ L L YMN +A+ KT+E+GK+  F R++ RL  K
Sbjct: 2   QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GETSG+  +V  I  DC+ ++L+ +       CH G  SC+           Q    + E
Sbjct: 61  GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQTNSIQ----VVE 116

Query: 125 RKSADPETSY 134
            K  DPE  Y
Sbjct: 117 EKVFDPENVY 126


>UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum
           ATCC BAA-798 RepID=D1CF76_THET1
          Length = 300

 Score =  138 bits (347), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 42/92 (45%), Positives = 66/92 (71%), Gaps = 1/92 (1%)

Query: 17  GLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVS 76
           GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W KGETSG  L+V  
Sbjct: 20  GLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLKGETSGRTLHVRE 79

Query: 77  IAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD 107
           + P+C+ ++LL+L +   P  CH G  SCF  
Sbjct: 80  LRPNCELNSLLILVDQRLPGACHTGHFSCFYR 111


>UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC
           23134 RepID=A1ZDC3_9SPHI
          Length = 130

 Score =  134 bits (337), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 47/112 (41%), Positives = 63/112 (56%), Gaps = 7/112 (6%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           +EK  GL+PV+VQ   SG+VLMLGY N  AL +TL++G  TF+S ++  LWTKG+TSG++
Sbjct: 15  FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74

Query: 72  LNVVSIAPDCDNDTLLVLANPIGP-TCHK------GTSSCFGDTAHQWLFLY 116
           L +  I  DCD D L+     +G   CH          SCF         L 
Sbjct: 75  LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCFYRKMASGKTLE 126


>UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HIS3_IGNH4
          Length = 129

 Score =  133 bits (336), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 36/99 (36%), Positives = 57/99 (57%), Gaps = 1/99 (1%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             L++   D  +  + Q   SG+VLM+  MN EA+ KTL +G V ++S++++ LW KG T
Sbjct: 14  ERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKELWVKGAT 73

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCF 105
           SG+   +     DCD D++L++        CH+G  SCF
Sbjct: 74  SGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCF 112


>UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58
           RepID=Q1NG03_9SPHN
          Length = 157

 Score =  132 bits (332), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 42/104 (40%), Positives = 58/104 (55%), Gaps = 1/104 (0%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            +GLMP IV +A    VLMLGYMN EAL +TL + +  F+SR+++ LW KGE SG    V
Sbjct: 25  AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGFRQRV 84

Query: 75  VSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQ 117
             +  D D D L+++     P +CH G  SCF       +   +
Sbjct: 85  DHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDK 128


>UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales
           RepID=HIS3_METVS
          Length = 136

 Score =  131 bits (331), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 37/107 (34%), Positives = 56/107 (52%), Gaps = 3/107 (2%)

Query: 6   QRRELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           Q  +L + K D   L+  I        VLM  +M+ E+L  TL++G + +FS ++ ++W 
Sbjct: 17  QNMDLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWM 75

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH 110
           KGE S N   V+ +  DCD D LL +    G  CH+G  SCF +   
Sbjct: 76  KGEESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNKVD 122


>UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira
           RepID=HIS3_LEPIN
          Length = 187

 Score =  129 bits (325), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 34/117 (29%), Positives = 58/117 (49%), Gaps = 9/117 (7%)

Query: 10  LDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LD++KT          L+PV+    + G++LM  + N E+   +L++G   +FSR++ +L
Sbjct: 61  LDFQKTTELLLTGKKNLVPVVAID-LQGQILMQAFGNEESQTLSLKTGYAHYFSRSRNQL 119

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           W KG+TSG+   ++ I    D   L+         CH+G  SCF     + +    L
Sbjct: 120 WKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERMEGVTWKLL 176


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  129 bits (324), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 41/137 (29%), Positives = 66/137 (48%), Gaps = 14/137 (10%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            ++ ++ DCDND +  +    G  CH     CFG+       + +LE+ L  RK + PE 
Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNLTG----IARLEKTLKARKESAPEG 221

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA+L+ +  K +  K+ EE  E   A T  D   +  EA+DL+Y  L      G+ + 
Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDAKTKED---VAFEAADLIYFALTKAVSAGVSVA 277

Query: 193 TVIENLR------KRHQ 203
            + ++L       KR +
Sbjct: 278 DIEKSLDAKGWKVKRRK 294


>UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms
           RepID=HIS2_PELTS
          Length = 98

 Score =  128 bits (323), Expect = 9e-29,   Method: Composition-based stats.
 Identities = 34/94 (36%), Positives = 50/94 (53%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
            +   +  L +++ +R+   P+ SYTA L+  G  +I +K+GEE  E  +AA       L
Sbjct: 2   GEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAAL 61

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             E +DL+YHLLVLL   GL    V+  L  R Q
Sbjct: 62  VGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95


>UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria
           RepID=HIS2_LEPBJ
          Length = 92

 Score =  126 bits (317), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 48/89 (53%), Positives = 61/89 (68%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
           FL QLE +L +RK   P+ SYTA L+  G  RI +KVGEE  E  +AA   D+ ELT+EA
Sbjct: 3   FLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTHEA 62

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL VLL +Q L L  V+E LRKRH
Sbjct: 63  ADLLFHLQVLLVEQELSLQDVVEELRKRH 91


>UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria
           RepID=HIS2_CLOB1
          Length = 110

 Score =  126 bits (316), Expect = 7e-28,   Method: Composition-based stats.
 Identities = 32/94 (34%), Positives = 51/94 (54%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
           ++   +  L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   D  EL
Sbjct: 2   NRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEEL 61

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             E  DL YH++VL+ ++ + L  + + L KR +
Sbjct: 62  IKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95


>UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5
          Length = 105

 Score =  124 bits (313), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 51/90 (56%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L  ++ +RK    + SYT  L+  G  +I +KVGEE  E  +A+   ++ +   E 
Sbjct: 1   MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            DL+YH+LVL+ ++ + L  + + L KR Q
Sbjct: 61  CDLIYHVLVLMANENITLEELRKELEKRRQ 90


>UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium
           RepID=HIS2_CLONN
          Length = 110

 Score =  124 bits (312), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 29/94 (30%), Positives = 51/94 (54%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   ++ +L
Sbjct: 2   DNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDDL 61

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             E  D++YH++VL+ ++ + L  +   L KR +
Sbjct: 62  IAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95


>UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae
           RepID=HIS3_SULSO
          Length = 85

 Score =  124 bits (311), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 35/76 (46%), Positives = 48/76 (63%)

Query: 33  MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92
           M+G MN EAL KTL +G + F+S ++++LW KGETSGNF  +     DCD D +L     
Sbjct: 1   MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60

Query: 93  IGPTCHKGTSSCFGDT 108
           +GP CH G  +CF  +
Sbjct: 61  LGPICHTGNYTCFYRS 76


>UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes
           RepID=HIS2_BACC2
          Length = 107

 Score =  123 bits (310), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 28/85 (32%), Positives = 49/85 (57%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + + ERK +    SYT  L++ G  +I +K+GEE  E  +A   +D+ E+  E  D+ 
Sbjct: 8   LYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVF 67

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YH  VLL ++ + L  V+  +++R+
Sbjct: 68  YHCFVLLAEKNIALEDVMREVKERN 92


>UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=A6LT24_CLOB8
          Length = 108

 Score =  123 bits (310), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 32/89 (35%), Positives = 48/89 (53%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +  L + + +RK+   E SYT  L+  GT +I +KVGEE  E  ++   +++ E  NE 
Sbjct: 4   NIKALYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINEI 63

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            DL YHLLVL+    + +  V   L KR 
Sbjct: 64  CDLTYHLLVLMAQMNISIEEVGAELEKRR 92


>UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa
           serovar Patoc RepID=B0SHA6_LEPBA
          Length = 202

 Score =  123 bits (310), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 1/103 (0%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L P + Q  ++G+ LML +   E+L   +ESG  T+FSR++   W KGE SG+F  +  I
Sbjct: 94  LSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQKLKQI 152

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
               +   +  + + IG  CH G  SCF     Q   +  +  
Sbjct: 153 YVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYS 195


>UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria
           RepID=HIS2_MAGSA
          Length = 109

 Score =  121 bits (305), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 42/91 (46%), Positives = 56/91 (61%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +L  ++A RK  DP+ SYTAKL+A G  +IAQK GEE VET +AA    + EL 
Sbjct: 4   DSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDELV 63

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E++D +YHLLVL  D G++   V   L +R
Sbjct: 64  GESADTLYHLLVLWADCGVEPAKVWAELARR 94


>UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria
           RepID=HIS2_NITMU
          Length = 121

 Score =  121 bits (304), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 49/92 (53%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L++L + +  RK +DP  SY AKL   G  +I +K+ EE  E  LA+   D   + 
Sbjct: 3   DPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTHVV 62

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            E +DL +H LVLL    L L  V++ LR+R 
Sbjct: 63  RETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94


>UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KWI3_HALNC
          Length = 124

 Score =  120 bits (302), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 44/94 (46%), Positives = 60/94 (63%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
           T +    L QL  ++ +RK ADP +SY A+L+A G  +IAQKVGEEGVE ALAA   D  
Sbjct: 3   TNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDNV 62

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            + +E +DL +H +VLL D GL    V++ L +R
Sbjct: 63  AIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96


>UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria
           RepID=HIS2_ACICJ
          Length = 133

 Score =  120 bits (302), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 34/96 (35%), Positives = 53/96 (55%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
             A     L +L   +  RK+ADP  S++A+L + G  ++AQK GEE VE  + A   +R
Sbjct: 14  PAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNR 73

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLV+    G+    V   L++R 
Sbjct: 74  TALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109


>UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZNB1_9GAMM
          Length = 125

 Score =  120 bits (302), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 34/97 (35%), Positives = 53/97 (54%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
             D       L  L +++ +R+ ADPE SY AKL+A G   + +K+GEE  ET +A    
Sbjct: 5   ASDARAGAELLSALAEVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKND 64

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D   L +E +DL +H L++L  +G     V++ L +R
Sbjct: 65  DSDALVSEMADLWFHSLIVLAARGRHPDDVLDELARR 101


>UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria
           RepID=HIS2_GRABC
          Length = 160

 Score =  120 bits (301), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 35/96 (36%), Positives = 56/96 (58%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           D  +    L +L +++ +R+ ADP  S++A+L + G  ++AQK GEE VE  + A   D+
Sbjct: 38  DPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLVL    G++   V   L KR 
Sbjct: 98  EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133


>UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum
           ATCC 11170 RepID=HIS2_RHORT
          Length = 117

 Score =  119 bits (300), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 36/88 (40%), Positives = 52/88 (59%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +  L  ++A R+ ADP TSYTAKL+  G  +I QK GEE  E  +AA V    ++  E+
Sbjct: 16  IIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAES 75

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +D++YHL+VL  D G+    V   L +R
Sbjct: 76  ADVLYHLMVLWADVGVTPDRVWAELARR 103


>UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales
           RepID=B0MMD1_9FIRM
          Length = 114

 Score =  118 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 37/98 (37%), Positives = 58/98 (59%), Gaps = 5/98 (5%)

Query: 111 QWLFLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
           +     ++ +++  RK+       PE SYT  L+  G  +I +KVGEE  ET +AA   D
Sbjct: 2   KMTVYEEIFEVIKARKAQYDAGNAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNAD 61

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             EL NE +DL+YH++VL  D+GL+ + V E L +R++
Sbjct: 62  NDELKNEINDLLYHVMVLCADRGLEWSEVEEVLSERNE 99


>UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria
           RepID=HIS2_ACIAC
          Length = 137

 Score =  118 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 7/112 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD---PETSYTAKLYASGTKRIAQKVGEEG 154
           H   S       H    L +L  ++  RK A+    + SY A+L   G     +K+GEE 
Sbjct: 3   HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62

Query: 155 VETALAATV----HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            E  +AA       D  +L  E +DL +H ++ L   GL    V+  L +R 
Sbjct: 63  TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114


>UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms
           RepID=HIS2_ALHEH
          Length = 109

 Score =  118 bits (297), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 36/93 (38%), Positives = 51/93 (54%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
           + Q   L  L ++L ER+ ADP TSY AKL+  G   I +KVGEE  E  +AA   DR +
Sbjct: 2   SEQRDILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQ 61

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +  E +DL +H L++L         V+  L +R
Sbjct: 62  VIYETADLWFHSLIMLSACDAGPDDVLAELERR 94


>UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM
           10642 RepID=C8SBH0_FERPL
          Length = 92

 Score =  118 bits (296), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
            L +L++++ ERK      SYTAKL     G  ++ +K GEE VE  LA    D+  +  
Sbjct: 1   MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EA+DL+YH +VLL    + +  V + LR+R +
Sbjct: 61  EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92


>UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei
           group RepID=HIS2_LACCB
          Length = 110

 Score =  118 bits (296), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 29/88 (32%), Positives = 45/88 (51%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           +  L   + ER++     SYT  L+  G  +I +KVGEE  E  +AA   D      E +
Sbjct: 8   IPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPAFILEVA 67

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           DL YH+LVL+ ++G+ +  +   L  R 
Sbjct: 68  DLTYHVLVLMVERGITVDQIATELASRE 95


>UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD
          Length = 101

 Score =  118 bits (295), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 36/95 (37%), Positives = 52/95 (54%), Gaps = 2/95 (2%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           E +  L+PV+V    SG++LML Y +   L+ T  +G   ++SR++Q +W KG +SG   
Sbjct: 2   ETSTKLLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQ 61

Query: 73  NVVSIAPDCDNDTL--LVLANPIGPTCHKGTSSCF 105
            V ++  DCD D L   VL    G  CH    SCF
Sbjct: 62  LVQAVYRDCDGDALNFRVLVLGDGRVCHTRQVSCF 96


>UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria
           RepID=HIS2_HALHL
          Length = 114

 Score =  117 bits (294), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 31/97 (31%), Positives = 50/97 (51%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                     L  L + + +R+ A  +TSY A+L+  G   I +KVGEE  E  +AA   
Sbjct: 4   AASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGG 63

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +R ++  E +DL +H LV+L   G+ +  V+  L +R
Sbjct: 64  EREQVVYETADLWFHTLVMLSASGVSVDEVLAELERR 100


>UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=HIS2_UNCMA
          Length = 95

 Score =  117 bits (293), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 28/94 (29%), Positives = 48/94 (51%), Gaps = 2/94 (2%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFEL 169
              L ++  ++A+RK    E SYT  LY    G  ++ +K+GEE  E  +AA      E+
Sbjct: 2   ADVLDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEI 61

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            +E +DL +H +VLL  + +    + E   +R +
Sbjct: 62  VSECADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95


>UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7
           genomosp. GTL1 RepID=A5KSK8_9BACT
          Length = 125

 Score =  116 bits (290), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 47/103 (45%), Positives = 59/103 (57%), Gaps = 7/103 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +D +  + L+   V       V       M GYMN  A++ TL  G VTFFSRT  +LW 
Sbjct: 20  VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79

Query: 64  KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           KGETSGN L +   I  DCD D+LL+ A P+G TCH G+ SCF
Sbjct: 80  KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCF 122


>UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria
           RepID=HIS2_MAGSM
          Length = 252

 Score =  116 bits (290), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 38/97 (39%), Positives = 51/97 (52%), Gaps = 2/97 (2%)

Query: 107 DTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVGEEGVETALAATVH- 164
                   L Q+ Q++ +RKSA  PE SY AKL+  G   I +KVGEE  E  LA     
Sbjct: 5   SPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKGRA 64

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            R E+ +EA+DL++H LV L    +  T V+  L  R
Sbjct: 65  ARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101


>UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae
           RepID=HIS2_METBF
          Length = 104

 Score =  115 bits (289), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 33/98 (33%), Positives = 52/98 (53%), Gaps = 2/98 (2%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHD 165
                  L ++ +++ +RK    E SY  KL     G  +I +KVGEE +ET LA    +
Sbjct: 2   PDADLSILNRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEN 61

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             E+ +E+SDL++HLLV+L    + L  +   L  RH+
Sbjct: 62  HEEIVSESSDLIFHLLVMLAANNVTLDEIAAELSARHE 99


>UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei
           RepID=HIS2_IGNH4
          Length = 102

 Score =  115 bits (289), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 54/92 (58%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             FL +L  ++ +R    P+ SYTA++   G    A+K GEE VE  +A+    R  +  
Sbjct: 2   SDFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIY 61

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EA+D++YHL+VLL  +G+D   VI+ L +R +
Sbjct: 62  EAADVIYHLMVLLALRGVDWAEVIKELERRSR 93


>UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales
           RepID=HIS2_BORA1
          Length = 116

 Score =  114 bits (286), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 30/98 (30%), Positives = 43/98 (43%), Gaps = 3/98 (3%)

Query: 108 TAHQWLFLYQLEQLLAERKSAD---PETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                  L ++   L  R   +   P+TSY AKL A G     +K+GEE  E  +AA   
Sbjct: 5   PVFGADVLARVADTLETRLPQNGGDPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDG 64

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
               + +E +DL +H LV L    L    V+  L +R 
Sbjct: 65  RPERIVSETADLWFHCLVTLAHYNLRPEDVLAELARRE 102


>UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria
           RepID=HIS2_NEIG1
          Length = 107

 Score =  114 bits (286), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 48/90 (53%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  ++Q + +RKSADP  SY A+L   G  +I +KV EE  E  +A+   D   L  E
Sbjct: 4   SVLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHLVYE 63

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL +H ++LL    L    V++ L +R 
Sbjct: 64  VADLWFHTMILLTHHDLKAEDVLDELSRRQ 93


>UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria
           RepID=HIS2_BRUA1
          Length = 107

 Score =  114 bits (286), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 40/91 (43%), Positives = 57/91 (62%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L  LE+++AER S    TSYTA L A G  + AQK+GEE VET +AA   DR  + 
Sbjct: 2   SQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGVV 61

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +E++DL+YHL V+    G+ L  V++ L++R
Sbjct: 62  SESADLLYHLAVVWNIAGVALEDVLQELQRR 92


>UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales
           RepID=HIS2_METB6
          Length = 104

 Score =  114 bits (285), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 2/100 (2%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATV 163
           G        + +L  ++ ER     E SYT++L     G  ++ +KVGEE  E  LA   
Sbjct: 5   GKEPVDLRVIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEESTEFILAVKN 64

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
                 T EA+DL +H+LV L+   +DL+ VI  L +R +
Sbjct: 65  GVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104


>UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BVA1_9PROT
          Length = 104

 Score =  114 bits (285), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 36/90 (40%), Positives = 59/90 (65%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
              L +L+QL+  +K +DP  SYTAKL++ G + I +K GEE +E  +A+   ++  + N
Sbjct: 1   MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           E++D++YHLLVLL ++ + L  VI  L +R
Sbjct: 61  ESADVLYHLLVLLSEKSVTLKEVISELERR 90


>UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria
           RepID=HIS2_BURCC
          Length = 121

 Score =  114 bits (285), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV---- 163
           T      L +L  ++  RK  DP+ SY ++L+  G   + +K+GEE  E  LAA      
Sbjct: 2   TQSTEDTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQG 61

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                L  E +DL +H LV+L    L    VI  L +R 
Sbjct: 62  GAPTALVGEVADLWFHCLVMLSHFDLSPADVIAELERRE 100


>UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales
           RepID=HIS2_LEUMM
          Length = 114

 Score =  113 bits (283), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 34/91 (37%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               + +L +   ERK      SYT  LY  G  +I +KVGEE  E  L A  ++  EL 
Sbjct: 2   PQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EELI 60

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E SDL++HL+VLL ++G+ L  + + L  R
Sbjct: 61  YETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91


>UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1
           Tax=Raoultella terrigena RepID=Q6U8A9_KLETE
          Length = 88

 Score =  112 bits (281), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 71/85 (83%), Positives = 75/85 (88%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
             LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMY
Sbjct: 4   AGLLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMY 63

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HL+VLLQDQ L L  +I NL+ RHQ
Sbjct: 64  HLMVLLQDQELSLQDIIANLKSRHQ 88


>UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis
           RepID=HIS2_ZYMMO
          Length = 107

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 43/89 (48%), Positives = 57/89 (64%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L  +E ++AER+ A PE SY + L+  GT  IAQKVGEE VET +AA   D+  L +EA
Sbjct: 5   TLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSLESEA 64

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL VLL D+G     V   LR+R 
Sbjct: 65  ADLIFHLAVLLADRGSSFENVFSELRRRE 93


>UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria
           RepID=HIS2_NITWN
          Length = 116

 Score =  111 bits (278), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 36/91 (39%), Positives = 51/91 (56%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           Q   ++ L  ++  R ++  + SYT KL   G    A+K+GEE VET +AA   DR  L 
Sbjct: 11  QRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKDRHHLI 70

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +DLM+H LVLL+  G+ L  V   L +R
Sbjct: 71  AEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101


>UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae
           RepID=HIS2_NATPD
          Length = 101

 Score =  111 bits (277), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 39/99 (39%), Positives = 56/99 (56%), Gaps = 2/99 (2%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATV 163
           GD       L +L +++  RK   P+ SYTA L+    G   + +K+GEE  E  LAA  
Sbjct: 3   GDGHDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKD 62

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            D  EL +EA+D++YHLLVLL  + ++L  +   LRKR 
Sbjct: 63  DDDEELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101


>UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales
           RepID=HIS2_MESSB
          Length = 112

 Score =  111 bits (277), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 36/91 (39%), Positives = 57/91 (62%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE ++AER ++    S+TA+L ++G  + A+K+GEE VET +AA   D+  L 
Sbjct: 2   NEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKALI 61

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E++DL+YH LV+L+  G+ L  V+  L  R
Sbjct: 62  AESADLVYHWLVVLKIAGVRLDEVMLELESR 92


>UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ
          Length = 127

 Score =  110 bits (276), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 37/95 (38%), Positives = 53/95 (55%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           +       L +L  L+  R+S   + SYTA+L  +G +R A+K GEE VET +AA   D 
Sbjct: 16  EFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSDA 75

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             L  EA+D +YHLLVLL+ + +    V+  L  R
Sbjct: 76  SALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110


>UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing
           symbionts RepID=HIS2_VESOH
          Length = 105

 Score =  110 bits (275), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 30/85 (35%), Positives = 48/85 (56%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +LEQ+L +RKSA  + SY + LY  GT  I +K+ EE  E  +A       ++  E +DL
Sbjct: 7   KLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEIADL 66

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
            +H LVLL+ + + +  +   L +R
Sbjct: 67  WFHTLVLLRFKKIKVEQITNELSRR 91


>UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SM22_9BACT
          Length = 100

 Score =  109 bits (274), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 28/88 (31%), Positives = 51/88 (57%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L +++ ERK+   + SYT +L   G+ +I +K+GEE  E   A    D  ++  E 
Sbjct: 5   IIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDVAGET 64

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +DL+YHL+V L+ + +    V+  L++R
Sbjct: 65  ADLLYHLIVALEFRNVQFEDVLGVLQER 92


>UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=A4EBZ9_9ACTN
          Length = 105

 Score =  108 bits (271), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 31/103 (30%), Positives = 49/103 (47%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G  +      +    L  L +++  R+ A P+ SYTA+L       + +K+ EE  E  +
Sbjct: 2   GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61

Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A   +D   +  EA DL+YHLLV L+  G+ L  +   L  R 
Sbjct: 62  ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARR 104


>UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum
           hungatei JF-1 RepID=Q2FUB9_METHJ
          Length = 91

 Score =  108 bits (271), Expect = 9e-23,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 51/90 (56%), Gaps = 2/90 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + ++  ++ ER +   E SYT+K+   + G  +  +K+GEE  E  +A    D+  ++ E
Sbjct: 1   MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL++H ++ L+  G+ L +V + L+ R 
Sbjct: 61  GADLLFHFMLALKRSGVTLQSVWDELQSRR 90


>UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae
           RepID=Q2CDY7_9RHOB
          Length = 106

 Score =  107 bits (268), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 1/89 (1%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + L  L + +A RK ADP+ S+TA+L AS  +  A+K GEE VE  + A   DR  L +E
Sbjct: 1   MSLAALAETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           A+D++YHLLV+     + L  +   L +R
Sbjct: 60  AADVIYHLLVMCAVNDITLADIERELERR 88


>UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae
           RepID=A4SV22_POLSQ
          Length = 133

 Score =  105 bits (263), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 14/101 (13%)

Query: 115 LYQLEQLLAERK------SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV----- 163
           L  L  ++ +R+      SADP+TSYTA L++ G   I +K+GEE  E  +AA       
Sbjct: 15  LAHLADVVDQRRDAFKAGSADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSN 74

Query: 164 ---HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                +  L  E +DL +H L+ L    L    VI  L +R
Sbjct: 75  LAAEQQKLLIGEMADLWFHCLIALSQFNLRPEDVIAELDRR 115


>UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis
           RepID=HIS2_SPHAL
          Length = 109

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 39/90 (43%), Positives = 54/90 (60%), Gaps = 1/90 (1%)

Query: 114 FLYQLEQLLAERKSADP-ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
            L +LE ++ +R +A   E SY A L A G  +IAQK+GEE VE  +AA   D   L  E
Sbjct: 8   TLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGE 67

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           ASDL++HL +LL ++GL    +   L +RH
Sbjct: 68  ASDLVFHLSILLAERGLTWDAIAAELDRRH 97


>UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae
           RepID=HIS22_BRAJA
          Length = 134

 Score =  104 bits (259), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 27/88 (30%), Positives = 46/88 (52%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           L +L   +   +  DP TS TA+L+  G  ++A+K+ EE +E  + A   D   +  E++
Sbjct: 5   LERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRESA 64

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           DL+Y+L VL    G+    V   + +R 
Sbjct: 65  DLLYNLTVLWASAGVRPEDVWREMTRRE 92


>UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TJZ9_9PROT
          Length = 104

 Score =  104 bits (259), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 30/89 (33%), Positives = 50/89 (56%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           + +L + +   ++  P  S TA+L   G  +IA+KV EE  E AL A V DR  +  E++
Sbjct: 5   IDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRESA 64

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           DL+Y+L+VL    G+  + V   + +R +
Sbjct: 65  DLLYNLMVLWVWMGITPSEVWAEMEQREK 93


>UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota
           RepID=HIS2_META3
          Length = 96

 Score =  102 bits (254), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 32/89 (35%), Positives = 52/89 (58%), Gaps = 4/89 (4%)

Query: 119 EQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
            +++ +R    PE SY A L  +       +I +KVGEE  ET LAA   D+ EL  E++
Sbjct: 8   FEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQELIYESA 67

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           DL++H+LVLL + G++   ++E   +R +
Sbjct: 68  DLIFHILVLLANNGIEYEELMEEFERRRK 96


>UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis
           HTCC2503 RepID=A3VQS9_9PROT
          Length = 109

 Score =  102 bits (254), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 38/90 (42%), Positives = 48/90 (53%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L   +  RK AD   SYTA L   G  R A+K GEE VE ALA  +  R +L  E
Sbjct: 6   ATLERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAE 65

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +D++YHL VLL    LD + +   L KR 
Sbjct: 66  TADVLYHLAVLLAANELDWSDISAALTKRE 95


>UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani
           RepID=HIS2_CLOTE
          Length = 107

 Score =  100 bits (249), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 29/88 (32%), Positives = 51/88 (57%), Gaps = 4/88 (4%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
           + +L +++ +RK  D   SY   L+   + +I +K+GE+  E  +A     + E  +E S
Sbjct: 7   IEELVEVIKDRK-NDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQVHEIS 62

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           DL+Y+L+VL+  Q +++  VIE L KR 
Sbjct: 63  DLIYNLMVLMMKQNIEIENVIEELGKRR 90


>UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K
           RepID=B4UDK1_ANASK
          Length = 110

 Score = 96.4 bits (239), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 35/98 (35%), Positives = 47/98 (47%), Gaps = 7/98 (7%)

Query: 111 QWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVH 164
              FL +L   +  R+  A P  SYT KL A+   RI +K+ EE  E   A         
Sbjct: 3   DERFLAKLWATIESRRADAAPAESYTKKLLAA-PARIRRKIIEEAYEVNEAHQALLDGKD 61

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +  L +EA+DL+YHL VLL    +  T V   L +RH
Sbjct: 62  TKDHLAHEAADLLYHLYVLLASADVTPTEVYGVLERRH 99


>UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp.
          HTCC2601 RepID=Q0FX88_9RHOB
          Length = 164

 Score = 95.3 bits (236), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 30/67 (44%), Positives = 40/67 (59%)

Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           DGLMP     A SGE+LMLG+M  EA   T+E+G+  +FSR +Q LW +G  SG  L +
Sbjct: 12 PDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKL 71

Query: 75 VSIAPDC 81
          V    + 
Sbjct: 72 VEARIED 78


>UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB
          Length = 101

 Score = 94.9 bits (235), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 26/86 (30%), Positives = 46/86 (53%), Gaps = 2/86 (2%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L   + +RK+ D + SYT+ L + G  +   K+ EE  E   A   +D+  + +EA+D +
Sbjct: 8   LVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHEAADTI 65

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRHQ 203
           YH+LV L+   +    V++ L  R +
Sbjct: 66  YHILVTLEAADIKFEDVLKELEGRKK 91


>UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium
           RepID=C4L178_EXISA
          Length = 102

 Score = 91.0 bits (225), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +++LEQL+  RK    E SYT  L+  G ++IA+K GEE  E  +AA      +L  E+
Sbjct: 1   MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL+YHLLVLL  +G+ L  V   L KRH
Sbjct: 59  ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87


>UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae
           RepID=Q0C645_HYPNA
          Length = 120

 Score = 90.7 bits (224), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 1/84 (1%)

Query: 120 QLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           + +  R    D  +S+TAKL A G    A KV EEG E A A        + +EA+D++Y
Sbjct: 22  ETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELADAVRRESDDRVASEAADVIY 81

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           H+ V L+ +G+ L  V   L  R 
Sbjct: 82  HVFVALRSRGVALDAVAGALEARQ 105


>UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD
          Length = 253

 Score = 90.7 bits (224), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 30/80 (37%), Positives = 50/80 (62%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ + +S +   S+T K+ A G  +I +KVGEE VE  LA    D   + +EA+D++YH+
Sbjct: 56  IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115

Query: 181 LVLLQDQGLDLTTVIENLRK 200
           L+LL   GL L T+ + +R+
Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135


>UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae
           RepID=HIS2_METS5
          Length = 93

 Score = 90.3 bits (223), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 38/90 (42%), Positives = 55/90 (61%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L  ++A+R    PE SYTA L   G   +A+KVGEE VE  +A+    R  + +E 
Sbjct: 4   VLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSET 63

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +DL+YHLLVLL  +G+ L  V + LR+R +
Sbjct: 64  ADLIYHLLVLLAMEGISLDEVRDELRRRMK 93


>UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae
           RepID=HIS2_METS3
          Length = 96

 Score = 86.8 bits (214), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 7/93 (7%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLY----ASGTKRIAQKVGEEGVETALAATVHDRFEL 169
            + ++ ++L ER+   P  SYT+K+          +I +KV EE  E  LAA       L
Sbjct: 6   IIREVYKVLEERRDN-PIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND--ENL 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             E+ DL++H L++L  +G+++  + E   +R 
Sbjct: 63  VYESVDLIFHTLLILVYKGIEIDEIFEEFARRR 95


>UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales
           RepID=Q0F926_9RHOB
          Length = 105

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 32/86 (37%), Positives = 55/86 (63%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L Q +  RK+   E SY ++L  SG+++ A+K GEE VE  +AA   D+  LT E++D+
Sbjct: 7   RLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEESADV 66

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++H+LV+L    +D  +V++ L +R 
Sbjct: 67  LFHMLVMLSSCDVDFKSVLKELERRE 92


>UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium
           HIMB114 RepID=D0RQN9_9RICK
          Length = 103

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
           +  L  L + + ERK++    SYT KL  +      +KV EE  E   A   +++    +
Sbjct: 2   FEVLEGLIKTIRERKNSSEHESYTKKLLDN-NSLCREKVMEEIKELVEAL--NEKKNEVH 58

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+D+MYH+LVLL+   + +  V+  L+KR 
Sbjct: 59  EAADVMYHILVLLEANNVKVEDVMNELKKRE 89


>UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae
           RepID=HIS2_RHOBA
          Length = 120

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 35/97 (36%), Positives = 47/97 (48%), Gaps = 3/97 (3%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD--- 165
               L L +L   L  R +  PE SYT KL   G + I +K+ EE  E   AA   D   
Sbjct: 2   PESLLPLDRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAG 61

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           R     EA DL+YH +VL+  +G++L  V   L +R 
Sbjct: 62  RQHAIYEAGDLIYHAMVLMAWRGIELDEVAAELARRE 98


>UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis
           RepID=B9RGV5_RICCO
          Length = 193

 Score = 84.5 bits (208), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 24/95 (25%), Positives = 44/95 (46%), Gaps = 7/95 (7%)

Query: 113 LFLYQLEQLLAERKSADPET-----SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
             LY LE  +++RK+          S+T +L       +  K+ EE  E       ++  
Sbjct: 84  TTLYSLESTISQRKAELAAPQEGKPSWTRRLL-DDPNLLCSKIREEADELCRTLEENEHS 142

Query: 168 -ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +E  D++YH +VLL  + + +  V++ LR+R
Sbjct: 143 IHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177


>UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WMR5_EGGLE
          Length = 163

 Score = 77.9 bits (191), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 34/134 (25%), Positives = 48/134 (35%), Gaps = 35/134 (26%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
           S     ++        L   +A R+ A  E SYT +L       + +KV EE  ETALAA
Sbjct: 9   SGEMPPSSQIGATFEALAATIAARREAG-EESYTYRLLTGSLDGVLKKVMEEAGETALAA 67

Query: 162 TVHDR----------------------------------FELTNEASDLMYHLLVLLQDQ 187
              +                                     L  EA+D++YHLLV+L+  
Sbjct: 68  KDVESWACSSLAASIAASGAVDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERY 127

Query: 188 GLDLTTVIENLRKR 201
           G+ L      L  R
Sbjct: 128 GIGLDEFAAELNNR 141


>UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus
           Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK
          Length = 90

 Score = 77.6 bits (190), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 30/93 (32%), Positives = 44/93 (47%), Gaps = 6/93 (6%)

Query: 114 FLYQLEQLLA---ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
            L  LE L+    +RKS+  E SYT KL          KV EE  E   A   +      
Sbjct: 1   MLNTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--I 57

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +EA+D+ YHLL+ L+   + +  V++ L  R +
Sbjct: 58  HEAADVFYHLLMYLEANDVKIEEVMQELENRKK 90


>UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces
           RepID=HIS2_STRCO
          Length = 90

 Score = 77.2 bits (189), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 26/76 (34%), Positives = 39/76 (51%)

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +  + DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V
Sbjct: 15  HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74

Query: 183 LLQDQGLDLTTVIENL 198
           ++  +G+ L  V  +L
Sbjct: 75  MMVARGISLDDVYAHL 90


>UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales
           RepID=HIS2_STRGG
          Length = 90

 Score = 76.8 bits (188), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 26/75 (34%), Positives = 38/75 (50%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +    DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V+
Sbjct: 16  KAAEGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVM 75

Query: 184 LQDQGLDLTTVIENL 198
           +  +G+ L  V  +L
Sbjct: 76  MVARGISLDDVYAHL 90


>UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria
           RepID=HIS2_METS4
          Length = 107

 Score = 72.2 bits (176), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 40/91 (43%), Positives = 59/91 (64%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L  L++++  R +A P+ SYTAKL A+G  + A+K+GEE VE A+AA   DR  L 
Sbjct: 2   TAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGLV 61

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +EA+D++YHLLV+L   G+ L  V+  L +R
Sbjct: 62  SEAADVLYHLLVVLVGSGVALEDVMAELERR 92


>UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria
           RepID=Q4JVP0_CORJK
          Length = 332

 Score = 71.4 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 27/83 (32%), Positives = 37/83 (44%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             L   L+ R    PE S T K   +G     +K+ EE  E  LAA      EL  E S 
Sbjct: 250 DSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDEELAEEISQ 309

Query: 176 LMYHLLVLLQDQGLDLTTVIENL 198
           L+Y L V++  +GL    + + L
Sbjct: 310 LLYWLQVVMVGRGLTPADIYKYL 332


>UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RQ70_FIBSS
          Length = 86

 Score = 71.0 bits (173), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 25/83 (30%), Positives = 42/83 (50%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            ++  L  +RK   PE   T +L+  G   I +K+ EE  E+ +AA    R     E S 
Sbjct: 4   EEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLELSQ 63

Query: 176 LMYHLLVLLQDQGLDLTTVIENL 198
           ++Y++ V++ ++GL L  V   L
Sbjct: 64  VLYYVAVMMAEKGLTLEEVYAKL 86


>UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria
           RepID=HIS2_MYCLB
          Length = 93

 Score = 66.4 bits (161), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 27/83 (32%), Positives = 35/83 (42%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             L   L+ER    P  S T      G   + +K+ EE  E  LAA    +  L  E S 
Sbjct: 11  EDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEEISQ 70

Query: 176 LMYHLLVLLQDQGLDLTTVIENL 198
           L+Y   VL+  +GL L  V   L
Sbjct: 71  LLYWTQVLMISRGLSLDDVYRKL 93


>UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1
           Tax=Streptococcus mutans RepID=Q8DTR6_STRMU
          Length = 61

 Score = 62.1 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 15/45 (33%), Positives = 25/45 (55%)

Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + A   D+ E+ +E +DL+YHL V+L + G+    V   L+ R 
Sbjct: 2   VIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46


>UniRef50_C0GPL2 Type III restriction protein res subunit n=1
           Tax=Desulfonatronospira thiodismutans ASO3-1
           RepID=C0GPL2_9DELT
          Length = 978

 Score = 59.5 bits (143), Expect = 7e-08,   Method: Composition-based stats.
 Identities = 18/84 (21%), Positives = 36/84 (42%), Gaps = 3/84 (3%)

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            ++ E+      +S + + +        QK+ EE  E   A    D+  +  E+SD++  
Sbjct: 22  SIIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYELFTAIANGDKESVLKESSDVLEI 78

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
            L +L+ Q      ++  L KR +
Sbjct: 79  TLTILKQQNYSFDDLLAELEKRRE 102


>UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZIN5_PLALI
          Length = 98

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 24/88 (27%), Positives = 43/88 (48%), Gaps = 3/88 (3%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNEA 173
           +LE  L  R    P  SY  +L  +G   +A  + E+  +   A    D     ++   A
Sbjct: 7   RLEAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPAAA 66

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +++++H ++LL+  G DL+TV   L +R
Sbjct: 67  ANVLFHWMLLLKAYGHDLSTVERELMQR 94


>UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium
           longum DJO10A RepID=UPI00003932E2
          Length = 68

 Score = 57.5 bits (138), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 15/45 (33%), Positives = 21/45 (46%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
            V  ++ DCD D LLV  + +G  CH G  SCF +     +    
Sbjct: 19  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 63


>UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae
           RepID=HIS2_PYRIL
          Length = 94

 Score = 54.4 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 39/93 (41%), Positives = 54/93 (58%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE+++  R       SYT +LY+SG   +A+KVGEE VE A+AA    +  + 
Sbjct: 2   SCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRIV 61

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            EA+DL+YHLLVLL   GL L  V   L +R +
Sbjct: 62  EEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94


>UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699CB9
          Length = 128

 Score = 52.5 bits (125), Expect = 8e-06,   Method: Composition-based stats.
 Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 5  QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39
          +   ++ W+  +GL+P I Q   +G++LM+ +MN 
Sbjct: 3  EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36


>UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ
          Length = 303

 Score = 48.7 bits (115), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 15/56 (26%), Positives = 25/56 (44%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
               ++  KV EE  E A A    D   ++ E  DL++ +  L +  G+D  T + 
Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALR 255


>UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SG07_9BACT
          Length = 257

 Score = 48.3 bits (114), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 14/61 (22%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVIEN----LRKR 201
             EE  E   A    D   +  E  D+ +H++   V+ +++G   +  V+      L +R
Sbjct: 36  FMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVLNEINEKLIRR 95

Query: 202 H 202
           H
Sbjct: 96  H 96


>UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X332_DESRD
          Length = 979

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 27/56 (48%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           QK+ EE  E      V ++  +  E++D++  +L +L+  G     +I  +  R +
Sbjct: 47  QKLLEEAYELFTEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102


>UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U6I7_HYDS0
          Length = 251

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 16/60 (26%), Positives = 29/60 (48%), Gaps = 4/60 (6%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLRKR 201
           +A+ V EE  E   A    D+  +  E +DL+    +H  +  +++  D+  V E L K+
Sbjct: 30  LAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVFELLIKK 89


>UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RLE1_FIBSS
          Length = 265

 Score = 44.0 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 15/61 (24%), Positives = 25/61 (40%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVIENL----RKR 201
           + EE  E   AA   D+  +  E  D    +++H  V  +     +  VI+ L     +R
Sbjct: 36  LVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVIQGLCEKMVRR 95

Query: 202 H 202
           H
Sbjct: 96  H 96


>UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide
           pyrophosphohydrolase domain fusion protein n=1
           Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT
          Length = 258

 Score = 43.3 bits (101), Expect = 0.006,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A    D  EL +E  DL+    +H  +  +++   +  V 
Sbjct: 27  EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86

Query: 196 ENLR----KRH 202
           +N+     +RH
Sbjct: 87  QNISEKMIRRH 97


>UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Gluconacetobacter
           diazotrophicus PAl 5 RepID=A9H4J7_GLUDA
          Length = 148

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 13/59 (22%), Positives = 24/59 (40%)

Query: 145 RIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           RIA+  G       +     DR  L  E+++ +  L+ +   + +    V   L +R Q
Sbjct: 58  RIARAFGLHAEHCVMELIADDRAALIRESAETLTRLMQIWAARNVSADAVWTELDRRTQ 116


>UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria
           RepID=A8I3U9_AZOC5
          Length = 283

 Score = 42.5 bits (99), Expect = 0.008,   Method: Composition-based stats.
 Identities = 11/56 (19%), Positives = 25/56 (44%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + +  K+ EE  E + A        + +E  DL++ ++ L +  G+D    + 
Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALR 230


>UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D9Q9_9ACTN
          Length = 336

 Score = 42.5 bits (99), Expect = 0.009,   Method: Composition-based stats.
 Identities = 18/65 (27%), Positives = 25/65 (38%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTV----IEN 197
           I + + EE  E   A    D   L  E  D    ++ H  + L +Q   L  V     E 
Sbjct: 61  ITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVCHGLAEK 120

Query: 198 LRKRH 202
           L +RH
Sbjct: 121 LIRRH 125


>UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM
          Length = 264

 Score = 42.1 bits (98), Expect = 0.012,   Method: Composition-based stats.
 Identities = 18/65 (27%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVIENLR-- 199
           IA+   EE  E   +   +D   L  E  DL+YH+L    +  +        VI+ L   
Sbjct: 35  IAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDVIQQLAAK 94

Query: 200 --KRH 202
             +RH
Sbjct: 95  LIRRH 99


>UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NET9_KYTSD
          Length = 144

 Score = 41.7 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 14/59 (23%), Positives = 21/59 (35%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVIENLR----KRH 202
           EE  E   A    D   L  E  DL++    H  +  +     +  V+  L     +RH
Sbjct: 44  EEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVVAELEAKLLRRH 102


>UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL
          Length = 180

 Score = 41.7 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 12/51 (23%), Positives = 21/51 (41%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
           + EE  E +  A       L  E +D++Y         G+DL  V+  + +
Sbjct: 85  LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135


>UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HVH1_9BACT
          Length = 292

 Score = 41.0 bits (95), Expect = 0.023,   Method: Composition-based stats.
 Identities = 33/192 (17%), Positives = 60/192 (31%), Gaps = 42/192 (21%)

Query: 42  LDKTLESGKVTFFSR-----------TKQRLW----------TKGET----SGNFLNVVS 76
           L+++LE G +   SR            ++ LW            G +    S +     S
Sbjct: 71  LEESLEDGDLHNLSREMGDVFIILFMARRILWEQTTVSLGEILDGASLKMVSRHPHVFES 130

Query: 77  IAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER---KSADPE 131
             P+   + +             H+   S           +  L+   A R   K+    
Sbjct: 131 PDPEKSLEAIWETWEEKKRAEAVHQDRRSV---LDGIPRTMPALQA--ASRLGQKAGRVG 185

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
             +T+ L       +  KV EE  E   AA       LT E  D+++ +    +  G+  
Sbjct: 186 FDWTSNL------SVLDKVEEECAE-IRAALSEGSARLTEEIGDMLFAMAQFARLSGIRP 238

Query: 192 TTVIENLRKRHQ 203
              +    K+ +
Sbjct: 239 EEALSEANKKFK 250


>UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LC99_MAGSM
          Length = 277

 Score = 41.0 bits (95), Expect = 0.024,   Method: Composition-based stats.
 Identities = 16/55 (29%), Positives = 25/55 (45%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            T  I  K+ EE  E A A   +DR     E  DL++ L+ L +   ++  T + 
Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233


>UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax=Bacillales
           RepID=A7GLU0_BACCN
          Length = 108

 Score = 41.0 bits (95), Expect = 0.024,   Method: Composition-based stats.
 Identities = 14/68 (20%), Positives = 28/68 (41%), Gaps = 5/68 (7%)

Query: 132 TSYTAKLYASG--TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
            ++T ++       + + +K  EE  E   A     +     E +DL+  +  L Q +G+
Sbjct: 21  KTFTTRMLDEQEYIEEVCKKTQEELAEYVEA---ESKEHKVEELADLLELVNALAQHEGV 77

Query: 190 DLTTVIEN 197
            L  V + 
Sbjct: 78  TLEDVEKV 85


>UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A3P2_NATTJ
          Length = 384

 Score = 41.0 bits (95), Expect = 0.024,   Method: Composition-based stats.
 Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 4/54 (7%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIENLR 199
           + EE  E   A    +   +  E  DL    ++H  V  +     L  V+  L+
Sbjct: 143 LIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVLTKLK 196


>UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD
          Length = 396

 Score = 41.0 bits (95), Expect = 0.025,   Method: Composition-based stats.
 Identities = 13/60 (21%), Positives = 24/60 (40%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +  K+ EE  E   A   +DR  + +E  D+++ L  L +  G      +    +R
Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234


>UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces
           RepID=D1X3V9_9ACTO
          Length = 335

 Score = 41.0 bits (95), Expect = 0.026,   Method: Composition-based stats.
 Identities = 25/107 (23%), Positives = 38/107 (35%), Gaps = 16/107 (14%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
           G        L  L Q++   +   P   +T++    G  + A    EE  E   A    D
Sbjct: 122 GSYDLPGARLLDLVQVMDRIRRECP---WTSRKTHRGLAKYA---IEEAYELVEAIEDGD 175

Query: 166 RFELTNEASDLM----YHLLVLLQDQGLDL--TTV----IENLRKRH 202
           R EL  E  D++    +H  +  +D         V    +E L  RH
Sbjct: 176 RDELREELGDVLLQVVFHARIAEEDPDEPFAVDDVAGGLVEKLIHRH 222


>UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3J2_SALRD
          Length = 281

 Score = 41.0 bits (95), Expect = 0.027,   Method: Composition-based stats.
 Identities = 23/110 (20%), Positives = 39/110 (35%), Gaps = 14/110 (12%)

Query: 101 TSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
             S F + A +      L  ++ + +   P   +  +      K +     EE  E   A
Sbjct: 13  YESQFAEPAERLEAYADLAAIVKQLRRDCP---WDREQTHESVKHLL---IEEAYEVVAA 66

Query: 161 ATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIE----NLRKRH 202
               D  EL  E  D+    ++H ++  +     L  VIE     L +RH
Sbjct: 67  IDHGDWDELAEELGDVLLHVLFHAVIAEEGGRFTLADVIEAETDKLVRRH 116


>UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9
          Length = 302

 Score = 41.0 bits (95), Expect = 0.028,   Method: Composition-based stats.
 Identities = 13/55 (23%), Positives = 21/55 (38%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
             + +  KV EE  E   A       E+  E  DL++ +  L +   +D    I 
Sbjct: 201 DARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIR 255


>UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1PZU0_9BACT
          Length = 283

 Score = 40.6 bits (94), Expect = 0.030,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A       +L  E +DL    ++H  +  + +  D+  V+    + + +R
Sbjct: 57  LVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVMKLCLDKMMRR 116

Query: 202 H 202
           H
Sbjct: 117 H 117


>UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GIZ4_9FIRM
          Length = 481

 Score = 40.6 bits (94), Expect = 0.033,   Method: Composition-based stats.
 Identities = 15/59 (25%), Positives = 24/59 (40%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E   A    D  +L  E  DL+    +H  +  ++Q      ++    E L +RH
Sbjct: 262 EEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIVAGITEKLVRRH 320


>UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6
           Tax=Bacteria RepID=Q3AFK8_CARHZ
          Length = 479

 Score = 40.6 bits (94), Expect = 0.035,   Method: Composition-based stats.
 Identities = 16/59 (27%), Positives = 24/59 (40%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E A A    D  +L  E  DL+    +H  +  ++       V+    E L +RH
Sbjct: 264 EEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVVEGICEKLIRRH 322


>UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF
          Length = 289

 Score = 40.6 bits (94), Expect = 0.036,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E A A    D  ++  E  D++    +H  +  + Q  DL  VI      L +RH
Sbjct: 59  EEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRH 117


>UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGC7_KOSOT
          Length = 256

 Score = 40.6 bits (94), Expect = 0.037,   Method: Composition-based stats.
 Identities = 14/61 (22%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIENLR----KR 201
           + EE  E   A    +  E   E  DL    ++H  +  +     +  V+E L     +R
Sbjct: 38  LIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVVETLSDKLIRR 97

Query: 202 H 202
           H
Sbjct: 98  H 98


>UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG family protein n=15
           Tax=Bacteria RepID=A4IJD4_GEOTN
          Length = 486

 Score = 40.2 bits (93), Expect = 0.039,   Method: Composition-based stats.
 Identities = 16/56 (28%), Positives = 27/56 (48%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + I QKV EE  E     +   R EL +E  D+M+ L+ L +  G+     ++
Sbjct: 387 NDVEPIWQKVEEEMAEFRAETSSGRRAELVSEFGDVMFALINLARYYGIQPEEALQ 442


>UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MG87_RHOM4
          Length = 283

 Score = 39.8 bits (92), Expect = 0.060,   Method: Composition-based stats.
 Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVI----ENLRKR 201
           + EE  E   A   +D  EL  E  DL+ H++   V+ +  G   L  VI    E L +R
Sbjct: 52  LIEEAYEVVSAIEENDWEELKRELGDLLLHVVFHSVMAEQAGRFTLKDVIETETEKLIRR 111

Query: 202 H 202
           H
Sbjct: 112 H 112


>UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TY54_METKA
          Length = 103

 Score = 39.8 bits (92), Expect = 0.060,   Method: Composition-based stats.
 Identities = 21/79 (26%), Positives = 31/79 (39%), Gaps = 14/79 (17%)

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           RK    E S  A+L             EE +E   A    +R  L  E  DL+  +   L
Sbjct: 30  RKDRAVEVSTGARLV------------EEAIEVRNAVRSGNREALIEELGDLLIEVEAFL 77

Query: 185 QDQGLDLTTVIENLRKRHQ 203
               +DL  ++E  R+R +
Sbjct: 78  TAHDIDLEEIVE--RQRTK 94


>UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C338_SPHTD
          Length = 466

 Score = 39.4 bits (91), Expect = 0.072,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 22/59 (37%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM---Y-HLLVLLQDQGLDLTTVIENLR----KRH 202
           EE  E   A    D   L  E  DL+   Y H  +  +     L  VI +L     +RH
Sbjct: 272 EEAYEVLEAIERDDAAALREELGDLLLQVYLHAQIAEEAGEFTLEDVIGDLSAKLVRRH 330


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero...   267   1e-70
UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri...   266   3e-70
UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ...   265   7e-70
UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac...   263   2e-69
UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob...   261   8e-69
UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon...   260   2e-68
UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell...   258   7e-68
UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI...   258   1e-67
UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri...   257   1e-67
UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   255   8e-67
UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm...   253   2e-66
UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   251   8e-66
UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   251   9e-66
UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific...   248   8e-65
UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi...   247   1e-64
UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell...   247   2e-64
UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   245   5e-64
UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact...   245   5e-64
UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba...   245   5e-64
UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac...   245   8e-64
UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   245   8e-64
UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   245   1e-63
UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana...   243   3e-63
UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   241   9e-63
UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul...   239   4e-62
UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm...   238   7e-62
UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p...   238   9e-62
UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ...   236   3e-61
UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   235   6e-61
UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy...   234   1e-60
UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote...   234   1e-60
UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   233   2e-60
UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman...   233   2e-60
UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy...   232   5e-60
UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   232   8e-60
UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI...   231   1e-59
UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos...   230   1e-59
UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   230   2e-59
UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   230   2e-59
UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5     230   2e-59
UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His...   230   3e-59
UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI...   228   6e-59
UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep...   228   7e-59
UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His...   228   9e-59
UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte...   228   1e-58
UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   226   3e-58
UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos...   225   7e-58
UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   225   8e-58
UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero...   225   9e-58
UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ...   225   1e-57
UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   222   9e-57
UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   216   3e-55
UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   215   8e-55
UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper...   208   1e-52
UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A...   207   1e-52
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   199   5e-50
UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI...   198   1e-49
UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel...   197   2e-49
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   189   4e-47
UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T...   188   8e-47
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   188   1e-46
UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros...   187   1e-46
UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz...   185   6e-46
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   182   6e-45
UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor...   175   6e-43
UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu...   174   2e-42
UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu...   174   2e-42
UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon...   171   1e-41
UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   168   9e-41
UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   168   1e-40
UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter...   167   2e-40
UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte...   167   2e-40
UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   167   2e-40
UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo...   166   3e-40
UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   166   4e-40
UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   166   4e-40
UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell...   164   2e-39
UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin...   164   2e-39
UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar...   163   3e-39
UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   163   3e-39
UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte...   163   4e-39
UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap...   163   4e-39
UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap...   162   7e-39
UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m...   162   7e-39
UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin...   162   8e-39
UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo...   161   1e-38
UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote...   161   1e-38
UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   161   2e-38
UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote...   161   2e-38
UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte...   160   2e-38
UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul...   160   2e-38
UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   160   3e-38
UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   160   3e-38
UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote...   160   4e-38
UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch...   159   5e-38
UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein...   159   5e-38
UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm...   159   5e-38
UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   159   5e-38
UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein...   159   7e-38
UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax...   158   7e-38
UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   158   9e-38
UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote...   157   2e-37
UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   156   3e-37
UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin...   156   3e-37
UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob...   156   3e-37
UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact...   156   4e-37
UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob...   156   4e-37
UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob...   156   4e-37
UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte...   155   6e-37
UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon...   155   8e-37
UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero...   155   1e-36
UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan...   154   1e-36
UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu...   154   2e-36
UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte...   153   5e-36
UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax...   153   5e-36
UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   152   5e-36
UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote...   152   6e-36
UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p...   152   6e-36
UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ...   152   7e-36
UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=...   150   4e-35
UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob...   150   4e-35
UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   150   4e-35
UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo...   149   5e-35
UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu...   149   5e-35
UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro...   149   6e-35
UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin...   148   8e-35
UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo...   148   9e-35
UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr...   148   9e-35
UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   147   2e-34
UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero...   147   2e-34
UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom...   146   5e-34
UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   145   1e-33
UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl...   144   1e-33
UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo...   141   2e-32
UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax...   139   6e-32
UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha...   135   7e-31
UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico...   134   2e-30
UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros...   131   1e-29
UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing...   130   2e-29
UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr...   129   6e-29
UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos...   127   2e-28
UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo...   124   1e-27
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   123   3e-27
UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos...   119   7e-26
UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid...   117   2e-25
UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   116   4e-25
UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu...   116   6e-25
UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact...   115   1e-24
UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=...   113   5e-24
UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact...   111   1e-23
UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost...   111   1e-23
UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm...   111   1e-23
UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C...   111   1e-23
UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph...   110   2e-23
UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh...   110   3e-23
UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo...   109   4e-23
UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap...   109   6e-23
UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta...   108   1e-22
UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto...   108   1e-22
UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph...   108   1e-22
UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi...   108   2e-22
UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell...   108   2e-22
UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk...   108   2e-22
UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri...   107   2e-22
UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins...   106   6e-22
UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto...   106   6e-22
UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul...   106   6e-22
UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote...   106   7e-22
UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot...   105   8e-22
UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot...   105   9e-22
UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha...   105   1e-21
UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra...   105   1e-21
UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl...   104   1e-21
UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...   104   2e-21
UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom...   104   2e-21
UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther...   104   2e-21
UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot...   104   3e-21
UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi...   103   4e-21
UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   103   5e-21
UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   102   8e-21
UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   102   8e-21
UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph...   101   1e-20
UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br...   100   5e-20
UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    99   7e-20
UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha...    99   1e-19
UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu...    99   1e-19
UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph...    98   1e-19
UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo...    98   1e-19
UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    97   3e-19
UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu...    97   3e-19
UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob...    97   3e-19
UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    96   5e-19
UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury...    95   1e-18
UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov...    93   4e-18
UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin...    93   6e-18
UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom...    92   1e-17
UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re...    91   2e-17
UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo...    90   7e-17
UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre...    89   1e-16
UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti...    88   1e-16
UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost...    87   4e-16
UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact...    85   1e-15
UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba...    84   3e-15
UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p...    84   3e-15
UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta...    82   9e-15
UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob...    82   1e-14
UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc...    82   1e-14
UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    82   1e-14
UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo...    81   1e-14
UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha...    81   3e-14
UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus...    80   4e-14
UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac...    79   1e-13
UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    78   2e-13
UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo...    77   3e-13
UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth...    76   5e-13
UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax...    71   2e-11
UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph...    64   4e-09
UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase...    59   9e-08
UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas...    59   1e-07
UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax...    59   1e-07
UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID...    54   3e-06
UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp....    53   4e-06
UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip...    51   2e-05
UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax...    51   2e-05
UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm...    51   2e-05

Sequences not found previously or not previously below threshold:

UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog...    48   2e-04
UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma...    48   3e-04
UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact...    47   4e-04
UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil...    47   4e-04
UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm...    46   7e-04
UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1...    46   7e-04
UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip...    46   9e-04
UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ...    46   9e-04
UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID...    46   0.001
UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus...    46   0.001
UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R...    45   0.001
UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ...    45   0.001
UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frank...    45   0.001
UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=A...    45   0.002
UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=...    45   0.002
UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC...    45   0.002
UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640...    45   0.002
UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX Re...    44   0.002
UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB...    44   0.004
UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str...    44   0.004
UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepI...    43   0.005
UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Str...    43   0.006
UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY...    43   0.006
UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC...    43   0.007
UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii K...    43   0.007

>UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C4Y5_SPHTD
          Length = 228

 Score =  267 bits (684), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 86/205 (41%), Positives = 121/205 (59%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGE
Sbjct: 14  VDAVRFD-ERGLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGE 72

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQ 117
           TSGN   VV I PDCD D LLV   P GPTCH GT +CF                  + +
Sbjct: 73  TSGNVHEVVEIRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDE 132

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           + +++AER++   E SYT  L  +G  +I +K+GEE  E  +AA   D   L NEA+DL+
Sbjct: 133 VARVVAERRAHPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLI 192

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLL+   +    V   LR R 
Sbjct: 193 YHLLVLLEASDVPTERVWAVLRTRR 217


>UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria
           RepID=C6PCK8_CLOTS
          Length = 228

 Score =  266 bits (681), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 80/204 (39%), Positives = 118/204 (57%), Gaps = 9/204 (4%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L ++   GL+P IVQ   + EVLM+ YMN E+L+K+LE+ +  FFSR++Q LW KG
Sbjct: 8   NIDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKG 66

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD--------TAHQWLFLYQ 117
           ETSGN  ++ +I  DCD DTLLV   P GP CH G +SCF             +   L  
Sbjct: 67  ETSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSN 126

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + +  RK      SYT  L+  G  +I +K+GEE  E  +A+    + E+  E +D +
Sbjct: 127 LYRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYI 186

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YHL+VL+ ++G++L  V + + KR
Sbjct: 187 YHLMVLMVEKGINLNDVYKEISKR 210


>UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT
          Length = 215

 Score =  265 bits (677), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 98/196 (50%), Positives = 135/196 (68%), Gaps = 2/196 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   +  VLMLGYMN EA  KT+E+ KVTF+SR++  LWTKGETS
Sbjct: 2   QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126
           GN+L++VSI  DCDNDTLLV  +P GPTCH GT +C+G+T   +  LFL +L+  +  R 
Sbjct: 62  GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P+ SYT  L+  G ++IAQKVGEE VET + A   +   L  EASD++YHL+VLL  
Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181

Query: 187 QGLDLTTVIENLRKRH 202
           +GL +  +   L +RH
Sbjct: 182 KGLHIEDLARELARRH 197


>UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria
           RepID=HIS2_VIBVY
          Length = 211

 Score =  263 bits (673), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 129/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
                   ++WEK DGL+P IVQ   S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL
Sbjct: 7   EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---GDTAHQWLFLYQL 118
           WTKGETSGN L +V+++ DCDNDTLLV  NPIGPTCH GT++C+        Q ++L+QL
Sbjct: 67  WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT  D+ EL  E++DL+Y
Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLLVLLQDQGL +  VI  L++RH+
Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211


>UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria
           RepID=B5EQF3_ACIF5
          Length = 230

 Score =  261 bits (668), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 80/209 (38%), Positives = 111/209 (53%), Gaps = 12/209 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W   DGL+P I Q A SG VLML +MN +AL  TL  G  T++SR++Q LW K
Sbjct: 10  AILAAVRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ---- 120
           GETSG+  ++V +  DCD DTLL+     GP CH G  +CF                   
Sbjct: 69  GETSGHIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGS 128

Query: 121 -------LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
                   L  R++ADP  SY A+L   G  RI +KVGEE  E  +A   H+   +  EA
Sbjct: 129 ILDSLQVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEA 188

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL+V L+++ L +  V+  L +R 
Sbjct: 189 ADLVFHLMVALEERDLHIDDVLGELARRE 217


>UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae
           RepID=C4V2J2_9FIRM
          Length = 235

 Score =  260 bits (665), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 79/220 (35%), Positives = 116/220 (52%), Gaps = 22/220 (10%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  +    + D     GL+P IVQ   + +VLML YMN E+L+KT+E+G   ++SR++Q+
Sbjct: 2   MNVDMSMIQFD---DRGLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQK 57

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105
           LW KGETSGN   +  I+ DCD DT+L+     G  CH GT SCF               
Sbjct: 58  LWKKGETSGNVQRIKEISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIP 117

Query: 106 ---GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
               +       L  L Q++  R+    E SYT  L+  G  +I +K+GEE  ET +A+ 
Sbjct: 118 LIEKEEHPLTEVLASLYQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASK 177

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + R ++  E  DL YH LVLL    +    ++E L++R+
Sbjct: 178 NNIREDVLYEMGDLWYHCLVLLAYHNMTPEDLLEELKRRN 217


>UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms
           RepID=HIS2_SYNPX
          Length = 222

 Score =  258 bits (660), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 72/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L+     +L +    GL+P I Q  + G VLM+ +MN E++ +TL SG+  ++SR++Q L
Sbjct: 4   LSPAFIDQLRF-NEAGLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLF------ 114
           W KG TSG+   + SI  DCD D LL+     G   CH G  SCF +   Q         
Sbjct: 63  WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122

Query: 115 ------LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                   +L +++  R+    E SYT KL   G  +I +K+GEE  E  +A    +  E
Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  EA+D+++H+ V L   G+    V E L  R 
Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216


>UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria
           RepID=Q2JWX9_SYNJA
          Length = 231

 Score =  258 bits (659), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 78/198 (39%), Positives = 107/198 (54%), Gaps = 9/198 (4%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P IVQ  + G VLM+ +MN E+L KTLE+G+  F+SR++Q LW KGETSG+   
Sbjct: 31  NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQW 90

Query: 74  VVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFG--------DTAHQWLFLYQLEQLLAE 124
           V  I  DCD+D L++L   +G   CH G  SCF         D       L Q+  ++  
Sbjct: 91  VKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKA 150

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R++     SYT+ L A G   I +K+GEE  E  +AA   D+  L  E +DL YH LV L
Sbjct: 151 RQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVAL 210

Query: 185 QDQGLDLTTVIENLRKRH 202
               +D+  V   L+ R 
Sbjct: 211 AHHQVDIRDVYRQLQARR 228


>UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria
           RepID=C6J1M1_9BACL
          Length = 231

 Score =  257 bits (658), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 92/213 (43%), Positives = 128/213 (60%), Gaps = 13/213 (6%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            E   + + W+   GL+P IVQ A S EVLML YMN E+L K++E+G+  F+SR++  LW
Sbjct: 15  IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------AH 110
            KG TSGN   + ++  DCD DTLLV     GP CH G  +CF  T              
Sbjct: 74  NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           ++  L +LEQL+AER +  PE +YT  L+  G  +I +KVGEE  E+ +AA   D  EL 
Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E SDL+YHLLVLL+++ L L  +++ L +RH+
Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226


>UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=A9B1U1_HERA2
          Length = 212

 Score =  255 bits (651), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 104/203 (51%), Positives = 130/203 (64%), Gaps = 10/203 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           EL ++ + GL+P +VQHA SGEVLM+GYMN EAL KT  SG VTF+SR++Q+LWTKGETS
Sbjct: 3   ELTYD-SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL---------FLYQLE 119
           GN L  ++   DCDND LL+LA P GPTCH G+ SCF  T              F+ QL 
Sbjct: 62  GNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLF 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + L ER+   P  SYT  L   G  +I +K+GEE  E  +AA   +  EL NEASDL+YH
Sbjct: 122 EFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYH 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           L VLL +QG+    V   LR+RH
Sbjct: 182 LFVLLLNQGVSPEDVWFTLRERH 204


>UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes
           RepID=HIS2_OCEIH
          Length = 215

 Score =  253 bits (647), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 84/207 (40%), Positives = 120/207 (57%), Gaps = 6/207 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M        L ++   GL+P IVQ   SG+VL L YMN +++ KT+E+ +  F+SR +Q 
Sbjct: 1   MTKSISIEHLQFD-EKGLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQE 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----L 115
           LW KG TSGN   V  I+ DCD D +LVL +  GP CH G  SCF +  ++        +
Sbjct: 60  LWNKGATSGNKQTVKQISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQII 119

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            Q+   + ER     E +YT+ L+  G  +I +K+GEE  E  +AA   D+ ELT+E SD
Sbjct: 120 PQVSAKIKERHEHPVEGAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSD 179

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202
           L+YH LVL++ QG+ L  + + L KRH
Sbjct: 180 LLYHSLVLMEQQGVTLEDIKKELYKRH 206


>UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Legionella
           RepID=C6N0X1_9GAMM
          Length = 207

 Score =  251 bits (642), Expect = 8e-66,   Method: Composition-based stats.
 Identities = 95/198 (47%), Positives = 131/198 (66%), Gaps = 1/198 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW+K +GL+P I+Q+A +G VLMLGYMN EAL  T+ +G++T +SR+++RLW KGE
Sbjct: 6   ISALDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGE 65

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQLLAER 125
           TSGN + V  I+ DCD+D+LL++  P GP CH G +SC+    H    F+  L +++ ER
Sbjct: 66  TSGNTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINER 125

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
                E SYTA+L ASG  R AQKVGEE VET +AA      E  NE +DL++HLLVLL+
Sbjct: 126 AETQAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLK 185

Query: 186 DQGLDLTTVIENLRKRHQ 203
              L    V++ L+ R +
Sbjct: 186 ASELSFYDVLQCLQDRDR 203


>UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=10 Tax=Bacteria
           RepID=C0QVS5_BRAHW
          Length = 220

 Score =  251 bits (642), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 115/205 (56%), Gaps = 6/205 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + + +  +L ++   GL+P IV    + EVL L YMN E+L+ +++  K  F+SR++Q L
Sbjct: 4   INQNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL-----Y 116
           W KGETSGN+ ++ SI  DCDND L++     GP CH G+ SCF +  +           
Sbjct: 63  WRKGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSID 122

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +L+  RK    E SYT  L+ SG  +I +KVGEE  E  + A      E   E SDL
Sbjct: 123 KLYKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDL 182

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           +YH LVL+ ++G+ +  +   L  R
Sbjct: 183 LYHSLVLMVEKGITINDIKNELASR 207


>UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae
           RepID=B4U8T9_HYDS0
          Length = 207

 Score =  248 bits (634), Expect = 8e-65,   Method: Composition-based stats.
 Identities = 80/205 (39%), Positives = 117/205 (57%), Gaps = 9/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+PVI Q A SGE+ ML Y N EA+ KT+E+G   +FSR++  +W KGE
Sbjct: 3   IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG-------DTAHQWLFLYQL 118
           TSG    V+ I  DCDNDTL+ +        CH G  +CF         +   +  L  L
Sbjct: 62  TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E+L+ +R S   E+SYT+KL   G  RI QKVGEE +E+ +A    D+ E+  E +DL+Y
Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           H+LV ++   +    V   L +RH+
Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206


>UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3
           Tax=Clostridiales RepID=C4Z9Z2_EUBR3
          Length = 427

 Score =  247 bits (632), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%)

Query: 1   MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           +L +    +L W      +DG++PVIVQ   + +VLML YMN EA + T+ SG++T++SR
Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108
           ++  LWTKG TSG+   V S+  DCD DT+L   + +G  CH    +CF +         
Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            +    L  +  ++ +R     E SYT  +   G   I +K+G E  E  LAA   D  +
Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           L  E SD MYH ++L+  + +    +   L +R
Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427


>UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms
           RepID=HIS2_THEP3
          Length = 216

 Score =  247 bits (631), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 79/215 (36%), Positives = 114/215 (53%), Gaps = 22/215 (10%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E   +EL ++   GL+PVI Q   + EVLM+ Y+    L K+LE+GKV +FSR++ +LW 
Sbjct: 2   ENILKELKFDDR-GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-------------- 109
           KGETSG+F  + SI+ DCD DTLL+    +   CH G  SCF                  
Sbjct: 61  KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120

Query: 110 -------HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
                       L ++  ++ +R     E SYT  L+  G  +I +KVGEE  E  + A 
Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             D+ E+  E SDL+YHLLVL+ ++G+ L  + E 
Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215


>UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI
          Length = 244

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 85/218 (38%), Positives = 115/218 (52%), Gaps = 27/218 (12%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + W+   GL+P I Q ++S EVLML YMN EAL+ TL++G   +FSR+KQR+W KGE SG
Sbjct: 6   IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------------- 106
           N   V  I  DCD+D++L+  N  G  CH G  SCF                        
Sbjct: 65  NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124

Query: 107 ---DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
               + + +  L  L   L ERK+AD  TSYTA L+A GT  IA+K+ EE  E   A   
Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            D  E+  E +D+ YH+LV L  + +    + + L KR
Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222


>UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria
           RepID=HIS2_XANCP
          Length = 206

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 115/197 (58%), Positives = 135/197 (68%), Gaps = 2/197 (1%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW K DGL+PVIVQ A +  VLMLGYMN EAL  T   G+VTFFSR+KQRLWTKGE
Sbjct: 12  LDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGE 71

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGN L VV+I  DCD DTLLV A P GPTCH G +SCF        FL  L+ L+AER+
Sbjct: 72  SSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTA--PSQFLGSLDALIAERE 129

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P  SYT KL+  G +RIAQKVGEEGVETALA  V    EL  E++DL+YHL+VLL+ 
Sbjct: 130 HERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRA 189

Query: 187 QGLDLTTVIENLRKRHQ 203
           +GL L   +  L  RH+
Sbjct: 190 RGLGLGDAVALLESRHK 206


>UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae
           RepID=C5SM65_9CAUL
          Length = 215

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 110/202 (54%), Positives = 136/202 (67%), Gaps = 1/202 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LT      LD+ K DGL+P IVQ A + +VLMLGYM+  AL +TL   +VTFFSR+K   
Sbjct: 11  LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLEQ 120
           W KGETSG+FLN+VS+  DCD D LLVLA P+GPTCH  T+SCF  DTA    F+  L  
Sbjct: 71  WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ +R  A P  SYTA+L   G  +IAQKVGEEG+ETALA    D  EL NEA+DL+YHL
Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
            VLL  +   L  V++ LR+RH
Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212


>UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria
           RepID=HIS2_BLOFL
          Length = 213

 Score =  245 bits (625), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT ++ + L+W K  GL+P I+QH++SGEVLMLGYMN E++  T ++G VTFFSR+K R
Sbjct: 1   MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGE+SGN L +++  PDCD D+LL+L  P G TCHK T+SCF      + FL+QLE 
Sbjct: 61  LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120

Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +K+      + ++SYT+ LY SG +RIAQKVGEEG+ETALAA   +   L +EASD
Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+YHLLVLLQ + L+   VI+ LR R +
Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208


>UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius LAA1 RepID=B7DRK3_9BACL
          Length = 254

 Score =  245 bits (625), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 77/250 (30%), Positives = 115/250 (46%), Gaps = 49/250 (19%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           +  + +   + ++   GL+PV+ Q A +GEVLM+ Y + EAL +TL +G   ++SR+++ 
Sbjct: 4   VKGDVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRRE 63

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G  +CF               
Sbjct: 64  YWRKGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAAD 123

Query: 109 --------------------------------AHQWLFLYQLEQLLAERKSADPETSYTA 136
                                                 L +L  ++  R    P+ SYT 
Sbjct: 124 EGGAKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTT 183

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDL 191
            L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+  
Sbjct: 184 YLFTHGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHP 243

Query: 192 TTVIENLRKR 201
             V   L KR
Sbjct: 244 VDVWRTLEKR 253


>UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=1 Tax=Candidatus Poribacteria
           sp. WGA-A3 RepID=D2MIV8_9BACT
          Length = 234

 Score =  245 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 113/205 (55%), Gaps = 14/205 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + ++   GL+P +VQ    G +LML YMN EALD+TL++G V F+SR++++LW KGETSG
Sbjct: 16  IQFD-ERGLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSG 74

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-------------LY 116
           ++L    +  DCD D LLV A P GPTCH    +CF                        
Sbjct: 75  HYLLCKRVFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFD 134

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +++ +RK+   E SY + L   G  RI +KV EE  E  LA     R E+ +E +DL
Sbjct: 135 RLYEMVLQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADL 194

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           ++H +V L    + +T + + L KR
Sbjct: 195 IFHSIVALGHCEIPMTAIQQELGKR 219


>UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius
           thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ
          Length = 211

 Score =  243 bits (620), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 87/202 (43%), Positives = 118/202 (58%), Gaps = 14/202 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V
Sbjct: 7   QDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIV 66

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ--------------LEQ 120
            S+  DCD DTLL L  P GP CH G +SCF +   +                    L Q
Sbjct: 67  TSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQ 126

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           L+ +R    P+ SY  KL   G  ++ +KVGEE  E   A    D+ E+ +E++DL++H 
Sbjct: 127 LIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHT 186

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
           L+ L+   +DL+ V++ L  RH
Sbjct: 187 LLALKYFQVDLSEVLQELHNRH 208


>UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WUY1_ALIAD
          Length = 256

 Score =  241 bits (616), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 79/255 (30%), Positives = 116/255 (45%), Gaps = 54/255 (21%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +   + ++   GL+PV+ Q A +G+VLML Y + EAL +TL +G   ++SR+++ 
Sbjct: 1   MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G   CF               
Sbjct: 61  YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120

Query: 109 -------------------------------------AHQWLFLYQLEQLLAERKSADPE 131
                                                A     L +L  ++  R    P+
Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186
            SYT  L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL + 
Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240

Query: 187 QGLDLTTVIENLRKR 201
            G+    V + L KR
Sbjct: 241 VGVQPADVWQVLEKR 255


>UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms
           RepID=C9RV77_GEOSY
          Length = 216

 Score =  239 bits (611), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 97/204 (47%), Positives = 128/204 (62%), Gaps = 10/204 (4%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
            ++ ++   GL+P IVQ A S EVL L YMN E+L+KTLE+G+  F+SR++Q LW KG T
Sbjct: 3   ADIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGAT 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---------GDTAHQWLFLYQL 118
           SGN   VV I  DCD D LLVL  P GP CH G+ SCF            A ++  L +L
Sbjct: 62  SGNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNEL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQ++A+R +  PE SYT  L+  G  +I +KVGEE  E  +AA   +  EL  EA+DL+Y
Sbjct: 122 EQIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVLL++Q L L  V+  L +RH
Sbjct: 182 HLLVLLREQKLPLDAVLATLAERH 205


>UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga
           RepID=HIS2_THEMA
          Length = 197

 Score =  238 bits (608), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+VQ   +GEVLML Y N EAL+ T ++G   FFSR +Q++W KGETSGN + VV I
Sbjct: 4   LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63

Query: 78  APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQWL------FLYQLEQLLAERKSAD 129
             DCD+D  L + +       CH G  SCF    H++       F  +L +L+ +RK   
Sbjct: 64  RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT KL+  G  +IA+K GEE VE       +DR  L  E +D+MYHL VL+ D G+
Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183

Query: 190 DLTTVIENLRKRHQ 203
            +  V+  L KR +
Sbjct: 184 TVQDVMRELEKRRK 197


>UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1
           Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL
          Length = 207

 Score =  238 bits (608), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 99/197 (50%), Positives = 133/197 (67%), Gaps = 1/197 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             +D+EK +GL+PV+VQ A + +VL L YM+  ALD+T++SG+ TFFSR++   W KGET
Sbjct: 5   AAIDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGET 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLEQLLAERK 126
           SG+ L+VV I  DCD+D L++  NP+G  CH   +SCFG         + +LEQ +AER 
Sbjct: 65  SGDRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERA 124

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           +ADP  S+TAKL   G KRIAQKVGEEGVETALA       EL +EA+DL+YHLLVLL  
Sbjct: 125 AADPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHA 184

Query: 187 QGLDLTTVIENLRKRHQ 203
           + +    V++ L  R +
Sbjct: 185 RNMVFQDVLDVLASRAE 201


>UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KI1_SYMTH
          Length = 210

 Score =  236 bits (603), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%)

Query: 27  VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86
            +G+VLM  YMN EAL  TLE+G   ++SR++Q LW KG TSG+   V  I  DCD D+L
Sbjct: 2   RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61

Query: 87  LVLANPIGPTCHKGTSSCFGD-----------------------TAHQWLFLYQLEQLLA 123
           L+L    G  CH+GT SCF                                L +L  +LA
Sbjct: 62  LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ER++     SYT++L+  G     +K+GEE  E  LA    DR  L  E +DL +H LV 
Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181

Query: 184 LQDQGLDLTTVIENLRKRH 202
           L DQGL    V + L  R 
Sbjct: 182 LVDQGLSPADVADQLASRR 200


>UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC
          Length = 251

 Score =  235 bits (601), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 80/237 (33%), Positives = 119/237 (50%), Gaps = 40/237 (16%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           + + ++DW+K  GL+PV++Q   +GEVLM+ YMN EAL+ T  +G   +FSR+K R+W K
Sbjct: 3   ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------------- 108
           GE+SGN   V S   DCDNDTLL+     G  CH G  SCF +                 
Sbjct: 62  GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121

Query: 109 -AHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
              ++  L +L  +  +RK +ADP+ SY AKLY  G     +K+ EE  E A A     R
Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181

Query: 167 F---------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                                 ++  E +DL++H++V L   G+    ++  L +R+
Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238


>UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae
           RepID=D0LRT4_HALO1
          Length = 241

 Score =  234 bits (598), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 83/204 (40%), Positives = 115/204 (56%), Gaps = 16/204 (7%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L 
Sbjct: 21  NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG---------------DTAHQWLFLYQL 118
           V  +  DCD D ++V+A P GPTCH GT SCF                 +      L +L
Sbjct: 81  VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140

Query: 119 EQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           E ++A R+  AD E SYT  L   G  +I  K+ EE  E A      +R E+ +E +DL+
Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           +H++V L  + + L  V   L +R
Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224


>UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria
           RepID=HIS2_HELHP
          Length = 231

 Score =  234 bits (598), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +   R++DWE+ + L+P IVQ   S ++LML Y + ++L+ +L++    +FSR+KQR+W 
Sbjct: 2   QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107
           KGE SG+  ++  +  DCDND+L+ +   +G  CH G  SCF                  
Sbjct: 61  KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120

Query: 108 ---TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                  +  L  L  ++ +R+  + E SYTA L A G   I +K+ EE  E   A    
Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D   +  E +DL YH+LV L  + +    V++ LR+R
Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217


>UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=4 Tax=Flavobacteriales
           RepID=A4CLC1_9FLAO
          Length = 206

 Score =  233 bits (596), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 88/203 (43%), Positives = 124/203 (61%), Gaps = 6/203 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            + +D+EKT GL+P I+Q + +  VLMLGYM+ EAL+ T  SGKVTF+SR+K+RLWTKGE
Sbjct: 1   MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGNFL  V +  DCD D LL+ A P GP CH G+ +C+ +            + +   +
Sbjct: 61  SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120

Query: 127 SADPET------SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
               +T      SY A L   GT ++AQKVGEE VET + A   D     NE++DL++H 
Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           L+LLQ +G  +  +   L +RH+
Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203


>UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B858_THEAS
          Length = 205

 Score =  233 bits (596), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 94/201 (46%), Positives = 119/201 (59%), Gaps = 6/201 (2%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             ++W   D L+PV+VQ A SG VLML Y N EALD TL+ G+  FFSR++ RLW KGET
Sbjct: 3   DRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGET 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQLL 122
           SGN + V+ +  DCD D++L L    GP CH G  SCF            LFL++L +++
Sbjct: 62  SGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIV 121

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +R S   + SYT  L+  G  RIAQKVGEEGVE ALA    DR     EA+DL+YHL V
Sbjct: 122 DQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTV 181

Query: 183 LLQDQGLDLTTVIENLRKRHQ 203
            L+     L    + L  RHQ
Sbjct: 182 ALRRVDATLLDAEQVLMARHQ 202


>UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP
           pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN
          Length = 215

 Score =  232 bits (592), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 83/205 (40%), Positives = 112/205 (54%), Gaps = 8/205 (3%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              E+ ++  +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++  LW KG
Sbjct: 2   NIEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKG 60

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ-------L 118
             SGN   V+ +  DCD D +L    P GP CH G  +CF                   +
Sbjct: 61  AISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKV 120

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + L  R    PE SY  K++ +G  RI +K+GEE  E  +AA    R EL  EASDL++
Sbjct: 121 YRTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLF 180

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLL  L + GL    +   L +R+Q
Sbjct: 181 HLLFTLTELGLSPQDLARVLWERNQ 205


>UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TLB5_9BACT
          Length = 188

 Score =  232 bits (591), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 87/187 (46%), Positives = 113/187 (60%), Gaps = 5/187 (2%)

Query: 22  IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81
           +VQ A SGEVLML Y N E++  TLE G++ F+SR+++ +W KG TSGN L + S+  DC
Sbjct: 2   VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61

Query: 82  DNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LYQLEQLLAERKSADPETSYTA 136
           D D +L   +P+GP CH G  SCF    H         L +L   L +R    PE SYTA
Sbjct: 62  DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +L A    R+AQK+GEEGVETALA    DR +   EA+DL+YHLLV L    L    +  
Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181

Query: 197 NLRKRHQ 203
            L+KRH+
Sbjct: 182 ELKKRHK 188


>UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3
           Tax=Chloroflexi RepID=B9KXC5_THERP
          Length = 218

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 82/205 (40%), Positives = 117/205 (57%), Gaps = 9/205 (4%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
               + +   DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KG
Sbjct: 9   LLGAIRFG-ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKG 67

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE- 124
           ETSG+ L +V +  DCD D LL   +P GPTCH G  SCF            +   + + 
Sbjct: 68  ETSGHVLELVELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILDE 127

Query: 125 -------RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
                  R       SYT+ L  +G  RIA+K+GEE  E  +AA   +   +  EA+DL+
Sbjct: 128 LASIIAARAVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLL 187

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLLQ  G+    V   L+ R 
Sbjct: 188 YHLLVLLQASGVPAGEVWRVLQARR 212


>UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc
           (Cinara cedri) RepID=Q058A1_BUCCC
          Length = 205

 Score =  230 bits (588), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 93/204 (45%), Positives = 131/204 (64%), Gaps = 1/204 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           ML +Q  + L+W K +GL+P I QH +SGE+LM GYMN +A DK + +   T +SR K+R
Sbjct: 1   MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLE 119
           +W KGETS NFL V +I+ DCD D +LV  NP G TCH    SCF       + FLY+LE
Sbjct: 61  IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
             +  +K     +SY + L++SG  RIAQK+GEE VE  +A   ++   + NE SDL++H
Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           L +LLQ   ++L  +I+NL+KR +
Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204


>UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Picrophilus torridus
           RepID=Q6KZD6_PICTO
          Length = 204

 Score =  230 bits (588), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 73/199 (36%), Positives = 111/199 (55%), Gaps = 13/199 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DG++PV+VQ   +G+VL L YM+  AL+ T+++G   ++SR+ +R+  KGE SGN   V
Sbjct: 9   NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFLYQLEQLLAE 124
           + I  DC++++LL+     GP CH G +SCF              +    L +LE L+ +
Sbjct: 69  MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R       SYT  L  SG + I +KVGEE +ET LA+    R  +  E +DL+YHL+V L
Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILAS---GRDRIVYETADLLYHLIVFL 185

Query: 185 QDQGLDLTTVIENLRKRHQ 203
               + L  V+  L +R +
Sbjct: 186 AFNNVSLFDVMNELNRRSK 204


>UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_PYRFU
          Length = 209

 Score =  230 bits (587), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 90/213 (42%), Positives = 124/213 (58%), Gaps = 14/213 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  E+   +++WEK +G++PVIVQ    GEVL L YMN EAL KTLE+G   ++SR+K R
Sbjct: 1   MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AH 110
           +  KGE SGN   V  I  DCDND LL++ +P GP CH G  SCF              +
Sbjct: 60  IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE+++  RK    E SYT+KL+  G ++I +K GEE +E  +A     R  + 
Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E +DL+YHLLVLL    + L  V+  LR+R +
Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209


>UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5
          Length = 229

 Score =  230 bits (587), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 80/199 (40%), Positives = 107/199 (53%), Gaps = 15/199 (7%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQ  ++G+V ML YM  E+L +TLE+G+ TFFSR++  LW KG TSGN L V S+
Sbjct: 10  LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE---------------QLL 122
             DCD D LL+LA P GPTCH G++SCF                             + L
Sbjct: 70  HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
             RK++    SYT KL   G   I  K+ EE  E A A        + +EA+D++YHLLV
Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L  +G+ L  V+  L  R
Sbjct: 190 GLASRGVPLRAVLSALASR 208


>UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT
          Length = 233

 Score =  230 bits (586), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 91/209 (43%), Positives = 128/209 (61%), Gaps = 8/209 (3%)

Query: 2   LTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTK 58
           L+E++   +  E   G   L+P +VQH  +G+VLMLGYM  EA + T  +GKVTFFSR++
Sbjct: 7   LSEKEILSVAEENAFGKADLIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSR 66

Query: 59  QRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL 113
           +++W KGETSGN L+V+ I  DCD DT+LVLA P+GPTCH G+ SCF           + 
Sbjct: 67  KKIWVKGETSGNGLDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFE 126

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
              +L+  + ERK+ DP+ SYTA L  S    + +K+ EE  E +LA  V  R    +E 
Sbjct: 127 VWSELQSTVRERKTGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEW 186

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL +H+ V L+  G+    V+E LRKR 
Sbjct: 187 ADLFFHIAVALEKTGVSWGEVMEILRKRQ 215


>UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum
           sp. NBC37-1 RepID=A6Q6T8_SULNB
          Length = 222

 Score =  228 bits (583), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +DW K + L+P I Q A + +VLML YMN EA + TL +G   +FSR+KQR+W KGE+SG
Sbjct: 3   IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115
           +   V  +  DCD DT+++     G  CH G  SCF               DT   +  +
Sbjct: 62  HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121

Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
             L   + ERK+A  E  S+T KL     + +  K+ EE  E  +A       ++  E++
Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV L  + +    V + L +R
Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207


>UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS
          Length = 257

 Score =  228 bits (583), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 79/244 (32%), Positives = 114/244 (46%), Gaps = 43/244 (17%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M   Q   E+ +    GL+P I QH  +G +LM+ +MN E+L  T E  +  +FSR++Q+
Sbjct: 1   MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFL---- 115
           LW KGE SG+F  V  I  DCD D +++     G   CH G  SCF        +     
Sbjct: 60  LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119

Query: 116 ------------------------------YQLEQLLAERKSADPETSYTAKLYASGTKR 145
                                           L QL+ ERK A+ +TSY + LY  G  +
Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179

Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           I +KVGEEGVET +AA          +  +L  E +DL +H +V+L    L+   +I+ L
Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239

Query: 199 RKRH 202
            +R 
Sbjct: 240 GRRQ 243


>UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT
          Length = 230

 Score =  228 bits (582), Expect = 9e-59,   Method: Composition-based stats.
 Identities = 85/206 (41%), Positives = 116/206 (56%), Gaps = 8/206 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +       +   + L PV+ Q    G+VLM+GYMN EA  +T+E G+VTFFSR+++RLWT
Sbjct: 2   DDAILRTLFPDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWT 61

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT--------AHQWLFL 115
           KGE+SG+FL +VS+  DCD DTLL L  P GPTCH GT SCF              +  L
Sbjct: 62  KGESSGHFLRLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETL 121

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             L   +A R+  DPETSY A+L +     + +K+ EE  ET  A    D     +E +D
Sbjct: 122 GDLAGTIALRRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMAD 181

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           L++HLLV ++        V+  L KR
Sbjct: 182 LLFHLLVAMERTRTPWEEVVGVLEKR 207


>UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria
           RepID=HIS2_AQUAE
          Length = 205

 Score =  228 bits (581), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 75/204 (36%), Positives = 116/204 (56%), Gaps = 10/204 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +L +   +GL+PVI Q   +GEV ML Y N EA+ KTLE+G   ++SR+++++W KGETS
Sbjct: 3   KLKF-NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT--------AHQWLFLYQLE 119
           G    V+ +  DCD D L+ +        CH G  +CF              +  L +L+
Sbjct: 62  GELQKVIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQ 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            ++ E+     E SYTAKL + G +R+ QK GEE VET +A    ++ E+  E++D++Y 
Sbjct: 122 DVIREKIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYT 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
            LV L   G+D+  V+E L +R +
Sbjct: 182 FLVSLSVSGIDIKEVMEELIRRFK 205


>UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_THET2
          Length = 214

 Score =  226 bits (577), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 81/202 (40%), Positives = 118/202 (58%), Gaps = 6/202 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGE
Sbjct: 3   LSAVRFD-EKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQL 121
           TSG+   VV +  DCD D ++    P GP CH G  +CF              + Q+   
Sbjct: 62  TSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYAT 121

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + ER    PE SY A+++ +G  RI +K+GEE  E  LAA   +  EL +EA+DL++HLL
Sbjct: 122 IKERLRTLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLL 181

Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203
           + L + GL    + + L +RH+
Sbjct: 182 LTLAELGLTPEDLAKTLWERHR 203


>UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP
           cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NG19_KYTSD
          Length = 244

 Score =  225 bits (574), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 95/222 (42%), Positives = 123/222 (55%), Gaps = 31/222 (13%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
            +   GL+  +VQ A +  VLM+G+M+  AL+ T  +G+VTF+SR++   W KGETSGN 
Sbjct: 22  TDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVKGETSGNT 81

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG------------------------- 106
           L+VVS+  DCD D +LV+A P GPTCH G +SCF                          
Sbjct: 82  LDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAASGAGGDA 141

Query: 107 ------DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
                  T      +  L + +AER    P  SYT  L+  GT+RIAQKVGEEGVETALA
Sbjct: 142 PASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEEGVETALA 201

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                  EL  E++DL+YHL+VLL D+GL L  V   LR R 
Sbjct: 202 GVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243


>UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4L5_GEMAT
          Length = 207

 Score =  225 bits (573), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 80/204 (39%), Positives = 111/204 (54%), Gaps = 5/204 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M +      LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++  
Sbjct: 1   MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG TSG+   V+S+A DCD D +L      GP CH GT+SCF DTA     +  L+ 
Sbjct: 60  LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119

Query: 121 LLAERKS---ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
            +A R+     D   SYT +L         +K+GEE VE A A    D    T E +DL+
Sbjct: 120 TIAARQQSLRDDERPSYTQRLLT-DRNLRLKKLGEEAVELATACVDGDVERATEETADLL 178

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YH LV L+  G  L  V   L +R
Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202


>UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes
           RepID=C6W0Y7_DYAFD
          Length = 213

 Score =  225 bits (573), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 104/211 (49%), Positives = 133/211 (63%), Gaps = 12/211 (5%)

Query: 5   QQRRELDWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    +D+ K  DGL+P ++Q   +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT
Sbjct: 3   ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF--------- 114
           KGETSGNFL V  IA DCD DTLL+ A P GP CH G  +CFG+   Q            
Sbjct: 63  KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122

Query: 115 --LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
              Y  ++++ ERK    + SYT+ L+  G  +IAQKVGEE VE  + +   D     NE
Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            SDL++HLLVLL+ + +DL  VI+ LR RHQ
Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213


>UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera
           aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR
          Length = 204

 Score =  225 bits (573), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 91/203 (44%), Positives = 125/203 (61%), Gaps = 1/203 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT  Q  +L+W+K + L+P+IVQ   S E+LM GY N ++L  TL+  K+TFFSRTK R
Sbjct: 1   MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LWTKGETS N+L V+ I PDCD D+LL L   IG TCH    SCF    +  +      +
Sbjct: 61  LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120

Query: 121 LLAE-RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            + +  K  +  TSYT+ LY  G  +I+QKVGEE VE  +AA   D+  +  E +DL+YH
Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVL     +    +I+ L+KR+
Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203


>UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
           n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD
          Length = 202

 Score =  222 bits (565), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 70/198 (35%), Positives = 102/198 (51%), Gaps = 5/198 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+   W KG 
Sbjct: 4   LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSGN   VV++  DCD D +L      GP CH GT +CFG      L             
Sbjct: 63  TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAP 122

Query: 127 SADPET---SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +  P+    SYT +L         +K+GEE  E   A    D      EA+D++YH+LV 
Sbjct: 123 AERPDDAPPSYTRRLLE-DRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVA 181

Query: 184 LQDQGLDLTTVIENLRKR 201
           ++  GL L  V   L +R
Sbjct: 182 VRPLGLSLDDVKAVLARR 199


>UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=2 Tax=Francisella philomiragia
           RepID=B0TY40_FRAP2
          Length = 207

 Score =  216 bits (551), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 102/201 (50%), Positives = 136/201 (67%), Gaps = 3/201 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + W+K D L+P I+Q A+   VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTK
Sbjct: 4   KIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTK 63

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL--YQLEQLL 122
           GE SGNFL +  IA DCDND++L+ A P GPTCH G+ SCF             +LE+L+
Sbjct: 64  GEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLI 123

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMYHLL 181
           AE+K   PE SY   L+  G  RIAQKVGEEGVE  +AA   D   EL +E +DL++HLL
Sbjct: 124 AEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLL 183

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
           VLL+++G+ L  + + L  R+
Sbjct: 184 VLLREKGISLEQICQKLVSRN 204


>UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8HTA8_CHLRE
          Length = 308

 Score =  215 bits (548), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 73/226 (32%), Positives = 117/226 (51%), Gaps = 31/226 (13%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L W+K + L+ VIVQH  +GEV+M  + +  A+ +TL++G  TF+SR++   W K
Sbjct: 67  SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107
           GETSG+F+NV ++  DCD D+++ L++PIGP CH G  +C+                   
Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185

Query: 108 -----TAHQWLFLYQLEQLLAERKSA------DPETSYTAKLYASGTKRIAQKVGEEGVE 156
                       L  LE+ +A+R+ A        + S+TA+L  +  + + +K+ EE  E
Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGE 244

Query: 157 TALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                     R    +E +DL+YH +VL   QG+ +  V+  LRKR
Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290


>UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta
           RepID=HIS2_ARATH
          Length = 281

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 74/219 (33%), Positives = 112/219 (51%), Gaps = 21/219 (9%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +     + W+   GL   I Q+  +G VLM G++N EAL  T+ S K TFFSR++  L
Sbjct: 51  KVDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTL 109

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL------ 115
           WTKGETS NF+N++ +  DCD D+++ L  P GPTCH G  +C+  +    L        
Sbjct: 110 WTKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGN 169

Query: 116 -------YQLEQLLAERKSA---DPET--SYTAKLYASGTKRIAQKVGEEGVETALAAT- 162
                  Y LE ++++RK       E   S+T +L       +  K+ EE  E       
Sbjct: 170 KLALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADELCRTLED 228

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             +     +E +D++YH +VLL  +G+ +  V+E LRKR
Sbjct: 229 NEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267


>UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU
          Length = 284

 Score =  207 bits (528), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 70/220 (31%), Positives = 112/220 (50%), Gaps = 25/220 (11%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+  I Q   +G +LM G+ + +A+  TL + K TF+SR++  LW K
Sbjct: 45  AFLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCK 103

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL----------- 113
           GETSGNF+ V S+  DCD D+L+ L  P GPTCH G  +C+                   
Sbjct: 104 GETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRH 163

Query: 114 -------FLYQLEQLLAERK----SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-A 161
                   LY+LE  +  R+    + D + S+T +L  +  + + +K+ EE  E      
Sbjct: 164 AAEEALTTLYELEATIEARRVEAVADDVKPSWTRRLLDN-PELLCKKIREEAGELCQTWE 222

Query: 162 TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +   TNE +D++YH +V+L  QG+ ++ V+  LR+R
Sbjct: 223 ENEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  199 bits (506), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 68/203 (33%), Positives = 104/203 (51%), Gaps = 9/203 (4%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT++   E+  ++ DGL   +V        L L Y + +++ K ++ G+  ++SR++  
Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLE 119
           +W KGETSGN   ++ I+ DCD+D L  +        CH  T SCFG+  H    L  LE
Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHG---LVGLE 249

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            LL +R    PE SYT +L+ + +  +  K+ EE  E   A     + EL+ EA+DL Y 
Sbjct: 250 SLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L  L    + L  V  NL  +H
Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328


>UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2
           Tax=Campylobacter RepID=B9D5P8_WOLRE
          Length = 329

 Score =  198 bits (504), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P +VQ + SGEVLML YMN EAL+ +L++G   +FSRTK R+W KGE S
Sbjct: 2   KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107
           GN   +  I  DCDNDT+L+     G   CH G  SCF                      
Sbjct: 62  GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121

Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
                      +  + ++   + +RK +ADP+TSY A L+  G   I +KVGEE  E  +
Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181

Query: 160 AATVHD 165
           A     
Sbjct: 182 ACKDAS 187



 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 13/35 (37%), Positives = 18/35 (51%)

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E+  EA+DL +H LV L   G+    V   L +R
Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315


>UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM
           16069 RepID=C7RAI7_KANKD
          Length = 412

 Score =  197 bits (500), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 69/201 (34%), Positives = 104/201 (51%), Gaps = 6/201 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L E     LD++K   L+P IVQ   +G VLML Y  PE+L   +   K  +FSR++  L
Sbjct: 216 LDEAVMACLDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNEL 274

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG TSGN   +++I  DCD DTL+      G  CH    SCF   +  +  L  L+++
Sbjct: 275 WEKGLTSGNQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANF-DLDVLDRV 333

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
             +R  +   TS++ KL AS      +K+ EE  E   A    D+ E+  EA+DL++  L
Sbjct: 334 FEQRMQSQEVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFAL 389

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
              + +G+  + +I  L  R+
Sbjct: 390 ARAKSKGVAASDIINELGARN 410


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  189 bits (481), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 62/191 (32%), Positives = 94/191 (49%), Gaps = 10/191 (5%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
             ++ DGL+P +V        L L Y + E++ + L++    + SR +  LW KG TSG+
Sbjct: 202 KSDRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGD 259

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              +V I+ DCDND L  +    G  CH   S CFGD       L +LE  L  RK + P
Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDL----KGLAKLESTLLSRKQSAP 315

Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190
             SYTA+L++   K +  K+ EE  E   A   +    +  EA+DL+Y  L      G+ 
Sbjct: 316 AGSYTARLFS-DEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVT 371

Query: 191 LTTVIENLRKR 201
           L  + ++L  +
Sbjct: 372 LADIEKSLDAK 382


>UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira
           pseudonana RepID=B8BUA9_THAPS
          Length = 272

 Score =  188 bits (479), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 13/198 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +  ++ DGL   +V    SGE L L Y + E++   L+SG+  ++SR++  LW KG+TSG
Sbjct: 59  VKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSG 117

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
           +F  +  +  DCD D L       G      CH  T +C+G+       L  LE  L +R
Sbjct: 118 HFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEP----RGLRHLEGTLQQR 173

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
               P  SYT +L+      +  K+ EE  E + A     +  +  E +D++Y  +V   
Sbjct: 174 LKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRAA 229

Query: 186 DQGLDLTTVIENLRKRHQ 203
             G+ +   +E L +R +
Sbjct: 230 KAGVSIDDAVEELDRRTR 247


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  188 bits (477), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 17/209 (8%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +        ++ DGL   +V     G  L L Y + E++ ++L +G+  + SR +  L
Sbjct: 191 VAKLVMANATSDRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-L 248

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE+SG+   +VS++ DCD+D L  +    G   CH  T +CFGD    +  L +L++
Sbjct: 249 WYKGESSGDIQELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQK 304

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L  RK + P+ SYTA+L+ +  + +  K+ EE  E   A T   +  +  EA+DL Y  
Sbjct: 305 TLQSRKESAPQGSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFA 360

Query: 181 LVLLQDQGLDLTTVIENLR------KRHQ 203
           L      G+ L  V  NL       KR Q
Sbjct: 361 LTKCVAAGVSLEDVERNLDAKSIKVKRRQ 389


>UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira
           RepID=B5VZW9_SPIMA
          Length = 200

 Score =  187 bits (476), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 17/197 (8%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+ + +Q  ++G VL LG MN EAL KTL + ++ +  +++  LW    
Sbjct: 21  IDKIRYD-DQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHP-- 77

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
                + + SI+ D   + L+         C    +   G        L  L +++ +R+
Sbjct: 78  ----DIILESISYDYRGNFLVAGV----AYCPSELNGSGGH------TLAGLFRVICDRR 123

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
                 SYT +L+A G  +I +K+GEE  E  +A    +   + +E +DL YH LV L  
Sbjct: 124 DHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAY 183

Query: 187 QGLDLTTVIENLRKRHQ 203
             +DL  V E L  R Q
Sbjct: 184 HQVDLRKVYEQLEARRQ 200


>UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces
           RepID=HIS2_SCHPO
          Length = 417

 Score =  185 bits (471), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 63/203 (31%), Positives = 101/203 (49%), Gaps = 11/203 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L +      + ++ DGL   +V + + G  L L Y + E++ ++L++G   + SR +  L
Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KG +SG   +++ I  DCD D L  +    G   CH  T  CFG        L QLE+
Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQA----SGLCQLEK 308

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L +RK+  PE SYTA+L++   K +  K+ EE  E   A T   +  +  E +DLMY  
Sbjct: 309 TLIDRKNNAPEGSYTARLFS-DPKLLRAKIMEEAEELCDATT---KENVIWEMADLMYFA 364

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +      G+ L  +  +L  +H+
Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  182 bits (462), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 61/208 (29%), Positives = 93/208 (44%), Gaps = 13/208 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L  ++TDGL    V  +     L L Y +P ++ K++ +G   + SR +  L
Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CHKGTS-SCFGDTAHQWLFL 115
           W KGE+SG    VVSI  DCD+D +         T     CH      CF         L
Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSA----TGL 307

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            +LE  L  R    P  SYTA+L+ +    +  K+ EE  E A A   +D+  +  EA+D
Sbjct: 308 AKLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAAD 365

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+Y  L      G+ L  +  +L  + +
Sbjct: 366 LIYFALTKCVSAGIGLEEIEASLDAKAK 393


>UniRef50_A0YJX3 Phosphoribosyl-ATP
           pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase
           n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN
          Length = 198

 Score =  175 bits (445), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 52/197 (26%), Positives = 88/197 (44%), Gaps = 13/197 (6%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ +    GL+P I+Q  + G VL L +M+ ++L KT E  +V     +   L +   
Sbjct: 15  IDKIRY-NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLL 73

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
            +G   +     P C +  +LV    I    ++               L ++ +++ +R+
Sbjct: 74  ITGWRYD-----PACQSLLILVECGSIAEPQNE-------FAQVSSNLLSEVFEVICDRR 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
               E SYT KL A G  +I +K+GEE  E  +A    D   + +E +DL YH LV +  
Sbjct: 122 DHPQEDSYTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAY 181

Query: 187 QGLDLTTVIENLRKRHQ 203
              DL  V   L +R +
Sbjct: 182 HRADLRQVYRKLAERRR 198


>UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN
          Length = 477

 Score =  174 bits (441), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 10/198 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
              + L  ++ D L   +V    +G  L L Y + E++   + SG+  ++SR++  LW K
Sbjct: 244 AFVKCLRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKK 302

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE+SGN   ++ I  DCD+D L    N  G   CH  T +C+G        L  LE +L 
Sbjct: 303 GESSGNAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHD----GGLRALESMLF 358

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R    P  SYT +L+    + +  K+     E    A      ++  EA+D+MY  +V 
Sbjct: 359 SRHENAPAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVR 414

Query: 184 LQDQGLDLTTVIENLRKR 201
               G  L+ V   L KR
Sbjct: 415 CVAAGCKLSDVERMLDKR 432


>UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms
           RepID=HIS3_PELLD
          Length = 137

 Score =  174 bits (441), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 6/133 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + ++   GL+P IVQ   +G+VLM+ +MN E+L+ TLE  K  ++SR++ +LW K
Sbjct: 10  SFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SGN  +V  I  DCD DTL++  + IG  CH G  SCF     +   +      + +
Sbjct: 69  GESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYRRVLENGNM-----EICD 123

Query: 125 RKSADPETSYTAK 137
               DPE  Y  K
Sbjct: 124 TLMFDPEEVYGKK 136


>UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4CVB3_9BACT
          Length = 128

 Score =  171 bits (434), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 52/131 (39%), Positives = 71/131 (54%), Gaps = 5/131 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L +   DGL+P IVQ   +  VLM+ +MN  +L+ TL++G + ++SR++Q+ W KGE
Sbjct: 3   LPNLKY-TADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSG+   VV  A DCD DTLL     IG  CH G  SCF                + E K
Sbjct: 62  TSGHTQKVVRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSPEGTPL----EITEEK 117

Query: 127 SADPETSYTAK 137
             DPE +Y +K
Sbjct: 118 LFDPEKTYASK 128


>UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_CHLP8
          Length = 137

 Score =  168 bits (427), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +     + ++   GL+P IVQ   +G+VLM+ +MN E+L  TLE  K  ++SR++ +LW 
Sbjct: 9   KSFLETVKFDDR-GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE+SGN  +V  I  DCD DTLL+  +  G  CH G  SCF         +      + 
Sbjct: 68  KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQM-----EIC 122

Query: 124 ERKSADPETSYTAK 137
           +    DPE  Y  K
Sbjct: 123 DTLMFDPEEVYGKK 136


>UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=C4XTP1_DESMR
          Length = 124

 Score =  168 bits (425), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 58/125 (46%), Positives = 73/125 (58%), Gaps = 7/125 (5%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           D+ K  GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+
Sbjct: 5   DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
              V S+  DCD DT+LVL   I G  CH+G  SCF              +     K  D
Sbjct: 65  VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFFTEITSDG------ERTCSPKVFD 118

Query: 130 PETSY 134
           P+  Y
Sbjct: 119 PKEVY 123


>UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT
          Length = 116

 Score =  167 bits (424), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 2/108 (1%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L +   D L+P I Q    G VLM+ +MN E++ KTL +G+  ++SR++ +LW KG
Sbjct: 7   WFEKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKG 65

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112
            TSG+   V  +  DCD DT+L+    IG   CH G  SCF +    +
Sbjct: 66  ATSGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113


>UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria
           RepID=HIS3_RHOPT
          Length = 151

 Score =  167 bits (423), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 2/127 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+ V+   A +G+VLM+ +MN EALD+T+++G+  ++SR+++RLW KGETSG+
Sbjct: 26  KFD-AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGH 84

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
              V+ +  DCD D + +  +   G  CH G  SCF     +      +       +  D
Sbjct: 85  IQKVLEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLIETDAERKFD 144

Query: 130 PETSYTA 136
           P+  Y  
Sbjct: 145 PDKVYGK 151


>UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_RHOPS
          Length = 147

 Score =  167 bits (423), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 1/124 (0%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +   A SGEVLM+ +MN EAL+KT++SG+  ++SR+++RLW KGE+SG+
Sbjct: 23  KFDAA-GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGH 81

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              V+ I  DCD D + +     G  CH G  SCF     +      L  ++   +  DP
Sbjct: 82  VQRVLEIRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTMVDADRLFDP 141

Query: 131 ETSY 134
              Y
Sbjct: 142 AKIY 145


>UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria
           RepID=B8J3P0_DESDA
          Length = 137

 Score =  166 bits (422), Expect = 3e-40,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 7/129 (5%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
                + + GL+P I Q   SGEVLML YMN EA  KTLE+G+  ++SR+++++W KG T
Sbjct: 14  EAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGT 73

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           SG+   V+++  DCD+DT+L+  + + G  CH G  +CF                     
Sbjct: 74  SGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE------WKDGAVSECAPM 127

Query: 127 SADPETSYT 135
             DP+  Y 
Sbjct: 128 VFDPQKVYG 136


>UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_STRTD
          Length = 112

 Score =  166 bits (421), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 47/106 (44%), Positives = 65/106 (61%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD++K  GL+PVIV    +G+VLML YMN  +   TLE+ ++ ++SR++  LW KG TS
Sbjct: 5   KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           G+F +V SI  DCD DTLL+     G  CH G  SCF    +    
Sbjct: 65  GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYDDNQ 110


>UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3
          Length = 140

 Score =  166 bits (421), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 70/133 (52%), Gaps = 5/133 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + ++K +GL+P I Q   +G+VLML YMN E+L+ TL+  K  ++SR++Q LW K
Sbjct: 10  KLMDIVRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           G TSGNF  V+ I+ DCD D +L+     G  CH G  SCF                + +
Sbjct: 69  GATSGNFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVENDNSSLS----ICD 124

Query: 125 RKSADPETSYTAK 137
           +   D E  Y   
Sbjct: 125 KLVFDAEEVYGKS 137


>UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R0U5_9PLAN
          Length = 310

 Score =  164 bits (415), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 41/128 (32%), Positives = 67/128 (52%), Gaps = 1/128 (0%)

Query: 11  DWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           D+ +    L+P I Q   +GEVLM+ +MN E+  +T+ +G+  ++SR++ +LW KGE SG
Sbjct: 173 DFSRGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESG 232

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           +   V  +  DCD DT+L+  + +G  CH+G  SCF             E+L+       
Sbjct: 233 HMQTVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYK 292

Query: 130 PETSYTAK 137
              S+   
Sbjct: 293 NPKSHAKS 300


>UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae
           RepID=HIS3_FRAAA
          Length = 132

 Score =  164 bits (415), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 46/108 (42%), Positives = 62/108 (57%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
               GL P I Q   +GEVLMLG+M+ EAL +TL +G+ T++SR++   W KG+TSG+  
Sbjct: 18  RNDAGLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQ 77

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
            V S+A DCD D +LV  + IGP CH GT +CF               
Sbjct: 78  WVRSVALDCDGDAVLVRVDQIGPACHTGTRNCFVADPLPTRVGDPGVT 125


>UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota
           RepID=HIS3_HALWD
          Length = 132

 Score =  163 bits (414), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 53/131 (40%), Positives = 73/131 (55%), Gaps = 10/131 (7%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ +  +DGL+P I Q A SGEVLML Y++P AL +T E+G+  ++SR+++ LW 
Sbjct: 11  DDAEIEIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWK 69

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGETSG+  ++  I  DCD DT+L L    G  CH G  SCF  T               
Sbjct: 70  KGETSGHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRTLDGTEVT-------- 121

Query: 124 ERKSADPETSY 134
             +  DPET Y
Sbjct: 122 -ERVFDPETVY 131


>UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_METTH
          Length = 138

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             + L+  + Q   +GEVLM+ YMN EAL +TLE+G   ++S ++ +LW KGE+SG+   
Sbjct: 19  NGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQR 78

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
           V  +  DCD D +++     G  CH G  SCF  +        + + +    K  DPE  
Sbjct: 79  VKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----KVFDPEEI 134

Query: 134 YT 135
           Y 
Sbjct: 135 YG 136


>UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria
           RepID=HIS3_SALRD
          Length = 127

 Score =  163 bits (412), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 7/133 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +++      D+   DGL+P IVQ A + +VLM+ YM  E L +TL++G++ ++SR++Q  
Sbjct: 1   MSDPLLDAADF-TDDGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQER 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG+TSG+   V     DCD DTLL   +  G  CH G  SCF   A            
Sbjct: 60  WVKGQTSGHTQTVEEARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAADDG------WT 113

Query: 122 LAERKSADPETSY 134
               K  DP+  Y
Sbjct: 114 TDGEKVFDPDAVY 126


>UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria
           RepID=Q2SLC2_HAHCH
          Length = 139

 Score =  163 bits (412), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 45/111 (40%), Positives = 66/111 (59%), Gaps = 1/111 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                EL +    GL+PVI Q A +  +LM  +MN EAL+KT+ + ++T++SR++QRLW 
Sbjct: 21  PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           KGETSG+   +VS++ DCD D +L L +  G  CH G  +CF         
Sbjct: 80  KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFYLQVEPDKQ 130


>UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria
           RepID=HIS3_DINSH
          Length = 119

 Score =  162 bits (410), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 45/115 (39%), Positives = 68/115 (59%), Gaps = 1/115 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             L ++   GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q  W KGE+
Sbjct: 6   ASLRYD-DQGLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGES 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           SG+   +V +  DCD D LL+     GP CH    +CF         +  +  ++
Sbjct: 65  SGHVQTLVEMRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119


>UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales
           RepID=C4Z0A8_EUBE2
          Length = 362

 Score =  162 bits (410), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 51/112 (45%), Positives = 71/112 (63%), Gaps = 1/112 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +   ++L  +  +GL+PV+VQ  V+ EVLML YMN EA +KTLE+G +T++SR++Q L
Sbjct: 251 KADISFKDLKLD-ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQEL 309

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           W KG TSG+F  V S+  DCDNDT+L     +G  CH G  +CF      W 
Sbjct: 310 WVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWN 361


>UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae
           RepID=HIS3_ACIC1
          Length = 142

 Score =  162 bits (410), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 45/99 (45%), Positives = 62/99 (62%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
               GL P + Q   +GEVLM+G+M+ EAL +TL +G+ T++SR++Q  W KGETSG+  
Sbjct: 18  RDEHGLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQ 77

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111
            V S+A DCD DT+LV  + IG  CH G  +CF      
Sbjct: 78  WVKSVALDCDGDTVLVKVDQIGAACHTGDRTCFDAGQLP 116


>UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R0N1_9RHOB
          Length = 156

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 47/138 (34%), Positives = 69/138 (50%), Gaps = 5/138 (3%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L ++   + D    +GL+   V    SGE+LM+GYMN E+L +T+E+G+  ++SR++Q  
Sbjct: 21  LGDELCPKFD---ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           W KG TSG    V+ I  DCD D +   V  +  G TCH G  SCF    +         
Sbjct: 78  WKKGGTSGQVQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWL 137

Query: 120 QLLAERKSADPETSYTAK 137
           +        DP+  Y  K
Sbjct: 138 EKTEVAPVYDPQEVYGKK 155


>UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria
           RepID=HIS3_BURS3
          Length = 138

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 47/132 (35%), Positives = 71/132 (53%), Gaps = 4/132 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                ++ W+  +GL+PVI Q A + +VLM  +MN EAL KT+E+ +  ++SR+++RLW 
Sbjct: 9   PAWLDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWF 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+  +V  +  DCD D +L+    + G  CH G  SCF       +       + 
Sbjct: 68  KGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVE 127

Query: 123 AERKSADPETSY 134
              K  DPE  Y
Sbjct: 128 PVLK--DPEHIY 137


>UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured
           crenarchaeote RepID=Q702A1_9CREN
          Length = 115

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 42/109 (38%), Positives = 66/109 (60%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   +LD+ K DGL+PV+VQ   + ++LML Y N  A++ T+++G   F+S ++ +LW 
Sbjct: 7   DEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWM 66

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112
           KGE SGN   V  I  DCD D++L L +   P CH G  +CF +  +  
Sbjct: 67  KGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHNRLYPN 115


>UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria
           RepID=HIS3_THICR
          Length = 147

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 48/131 (36%), Positives = 72/131 (54%), Gaps = 7/131 (5%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E  ++++ ++  +GL+P I Q   S EVLM+ +MN  AL +TLE+G+V ++SR++Q  W 
Sbjct: 22  EAVKKQVKYD-DNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR 80

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE SG    +  +  DCD D +L+L +  GP CH G  SCF    H          ++ 
Sbjct: 81  KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPII- 139

Query: 124 ERKSADPETSY 134
                DPE  Y
Sbjct: 140 -----DPEALY 145


>UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria
           RepID=HIS3_CORJK
          Length = 127

 Score =  160 bits (406), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 60/108 (55%), Gaps = 1/108 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       + +   DGL+P IVQ   +G+VLM+ +MN  AL  TL + K T++SR++Q  
Sbjct: 19  LDPAIAERVRF-NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
           W KGETSG+   V  +  DCD DT+L+     G  CH G  +CF    
Sbjct: 78  WIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADR 125


>UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms
           RepID=HIS3_SOLUE
          Length = 126

 Score =  160 bits (405), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 7/130 (5%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            LD+ K+DGL+  ++Q   SG VLM+GYMN EA +KT+E+G  TF+SR++++LW KGE+S
Sbjct: 2   NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           G+ L V  I+ DCD D +LV     GP  CH+G  SCF         L   E  +A+  +
Sbjct: 62  GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRR------LDAGEWKVADNPT 115

Query: 128 ADPETSYTAK 137
            DP   Y  K
Sbjct: 116 YDPGAVYGGK 125


>UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria
           RepID=A4GIE4_9BACT
          Length = 132

 Score =  160 bits (405), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 41/94 (43%), Positives = 64/94 (68%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q   +GEVLM+ +MN  +L +TL +G++ ++SR+++ LW KG+TSG+   +
Sbjct: 15  ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           + +  DCD D++LVL +  G  CH+GT SCF   
Sbjct: 75  IELRYDCDADSILVLVDQSGAACHEGTRSCFTRR 108


>UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_GEOSF
          Length = 126

 Score =  160 bits (405), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++D++K  GL+P ++Q   SGEVLM+ +M+ + LD TL+ GK  FFSRT+ + W KGE
Sbjct: 1   MIKIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
            SGN   V+ +  DCD DT+++     GP  CH G  SCF       +     + +    
Sbjct: 61  ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFY------VKWEDGQWVEHSN 114

Query: 126 KSADPETSY 134
              DP   Y
Sbjct: 115 PLFDPNEVY 123


>UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria
           RepID=HIS3_SILST
          Length = 129

 Score =  160 bits (404), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 62/108 (57%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P I Q   SGE+LM+ +MN E++ KTLE+G+VT++SR++Q  W KGE+SG+   
Sbjct: 21  NEAGLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQE 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           +V +  DCD D LL +    GP CH    SCF            +  +
Sbjct: 81  LVELRVDCDRDALLAMVRQTGPACHTNRRSCFYTAIRDGEEHEIMTPI 128


>UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC
           49814 RepID=C6XNB8_HIRBI
          Length = 139

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 59/108 (54%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+  I Q   S EVLML +MN +AL  T+E+G+  ++SR++ +LW KG+TSG +  
Sbjct: 30  NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           V SI  DCD D +L+        CH G  SCF         L   E  
Sbjct: 90  VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYRQITDLSTLNPTEDK 137


>UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM
          Length = 151

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 46/114 (40%), Positives = 63/114 (55%), Gaps = 1/114 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               +L +    GL+P + Q A +G+VLML +MN  A++KTLE+G++T+FSR++  LW K
Sbjct: 33  DVIEQLAY-NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVK 91

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           G  SGN   +V    DCD D LL      G  CH G  SCF   A+       L
Sbjct: 92  GLASGNHQQLVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145


>UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca
           ATCC 27029 RepID=D1SGQ9_9ACTO
          Length = 444

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 43/96 (44%), Positives = 59/96 (61%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
              DGL+  +V+   SGEVLM+ +M+ EAL +TL +G+ T++SR++   W KG TSGN  
Sbjct: 339 RTPDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQ 398

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            V S+A DCD D LLV    +G  CH G  +CF   
Sbjct: 399 YVRSVALDCDGDALLVSVEQVGAACHTGQRTCFFTE 434


>UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268
           RepID=C8PI34_9PROT
          Length = 336

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 54/135 (40%), Positives = 65/135 (48%), Gaps = 3/135 (2%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P IVQ A  G VLML YMN EAL  TL +G   +FSR+K R+W KGE S
Sbjct: 2   KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWL-FLYQLEQLLAERK 126
           G+   V S   DCDND LL+     G   CH G  SCF                      
Sbjct: 62  GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKEISLQKCGENVGSSSTCGAI 121

Query: 127 SADPETSYTAKLYAS 141
           +     S T  L   
Sbjct: 122 NFAEHGS-TTSLAQK 135



 Score = 66.0 bits (160), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 28/132 (21%), Positives = 46/132 (34%), Gaps = 24/132 (18%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVG 151
                +             +  L ++  +  +RK    P  SY A LYA G     +K+ 
Sbjct: 194 DAAAQNSTL--ENSAEKGPYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251

Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190
           EE  E ALA     R EL  + +              D++Y        LL+ L    + 
Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311

Query: 191 LTTVIENLRKRH 202
              +++ L +R 
Sbjct: 312 PDALLDELARRQ 323


>UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria
           RepID=B9QYY7_9RHOB
          Length = 159

 Score =  159 bits (402), Expect = 7e-38,   Method: Composition-based stats.
 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            +++ DGL+  +V    + EVLM+GYMN EAL +T+E+G+  ++SR+++  W KGETSG 
Sbjct: 32  KFDQ-DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQ 90

Query: 71  FLNVVSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D L+V       G TCH G  SCF                + + K  
Sbjct: 91  IQKVQEILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANVEKEKVY 150

Query: 129 DPETSYTA 136
           DP+  Y  
Sbjct: 151 DPKKVYGK 158


>UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F746
          Length = 123

 Score =  158 bits (401), Expect = 7e-38,   Method: Composition-based stats.
 Identities = 48/111 (43%), Positives = 67/111 (60%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T +  REL    +DGL+PVIVQ   + EVLM+ +M+ EA+++TL +G   ++SR++Q  W
Sbjct: 13  TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
            KGETSGN   V S++ DCD D LL+     GP CH  T +CF        
Sbjct: 73  VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCFTGRTISAN 123


>UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_RALEJ
          Length = 135

 Score =  158 bits (401), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 49/137 (35%), Positives = 72/137 (52%), Gaps = 4/137 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   ++ W+  +GL+PVIVQ   + +VLM  +MN +AL KT E G+  F+SR+++RL
Sbjct: 1   MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE SG+   V  +  DCD D +L+    +    CH G  SCF             + 
Sbjct: 60  WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEG--DAESGDW 117

Query: 121 LLAERKSADPETSYTAK 137
              E    DP   YTAK
Sbjct: 118 QTVEPVLKDPSQIYTAK 134


>UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria
           RepID=HIS3_CHRSD
          Length = 146

 Score =  157 bits (397), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 45/104 (43%), Positives = 62/104 (59%), Gaps = 1/104 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T        W    GL+P I Q   SGEVLM+ +MN  AL++TL +G+V ++SR++ + W
Sbjct: 19  TRDLLDAARWNDA-GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
            KGE+SG    +V+   DCD DTLL+  +  GP CH G  SCF 
Sbjct: 78  RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFY 121


>UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_PSEU2
          Length = 130

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 3/130 (2%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ W  +DGL+P I Q   +G VLM+ +MN EAL  T    +  ++SR++ +LW 
Sbjct: 2   KDWLDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+   +  +  DCD D ++++   IG   CH G  SCF    ++      ++ +L
Sbjct: 61  KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYR-VYEKSGWKTVDPVL 119

Query: 123 AERKSADPET 132
            +  +  P  
Sbjct: 120 KDPDAIYPAG 129


>UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class)
           RepID=HIS3_CLAMS
          Length = 138

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 46/107 (42%), Positives = 65/107 (60%), Gaps = 1/107 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            +       +   DGL+P ++Q   + EVLMLGYM+ EAL +TL +G+VTF+SR++   W
Sbjct: 16  VDGILARASF-ADDGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYW 74

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
            KG+TSG+   V   A DCD DT+LV  + +G  CH GT +CF    
Sbjct: 75  RKGDTSGHGQYVRDAALDCDGDTVLVQVDQVGVACHTGTRTCFDADH 121


>UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium
           HTCC2255 RepID=Q0FGM5_9RHOB
          Length = 120

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 43/116 (37%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L ++  +GL+P +VQ   + EVLM+ +MN  +L+KT E+   TF+SR+++ LW KG 
Sbjct: 6   ISSLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGL 64

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           TSGN   V  +  DCD D +L+L  P GP CH    +CF     +      L    
Sbjct: 65  TSGNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTELEEGSENIILNPET 120


>UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria
           RepID=HIS3_ACIAC
          Length = 141

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 53/134 (39%), Positives = 69/134 (51%), Gaps = 11/134 (8%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               E+ W+   GL+PVI Q A +G+VLM  +MN EAL KT E G+  +FSR++ RLW K
Sbjct: 14  SWLDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFK 72

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           GE SG+   V  I  DCDND +L+    +    G  CH G  SCF         L     
Sbjct: 73  GEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFS------VLKDGAW 126

Query: 121 LLAERKSADPETSY 134
              +    DPE+ Y
Sbjct: 127 QAVDPVLKDPESIY 140


>UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae
           RepID=HIS3_GLUOX
          Length = 156

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 2/124 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +    ++ ++  +GL+  + Q A  G VLML +MN +AL +TL +G+V ++SR++Q+L
Sbjct: 30  IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGETSG    ++    DCD D +L++ +  G  CH G  SCF             +  
Sbjct: 88  WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYHGVTPDGLRDTSQPE 147

Query: 122 LAER 125
           ++  
Sbjct: 148 ISAE 151


>UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales
           RepID=HIS3_RHISN
          Length = 152

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  A  GE+LM+ +MN EAL  T+E+G   ++SR++  LW KGE+SGN
Sbjct: 24  RFD-EKGLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGN 82

Query: 71  FLNVVSIAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D + +     G   TCH G  SCF  T        ++  +  E +  
Sbjct: 83  TQAVQEIRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARV-TITDEHRHF 141

Query: 129 DPETSYTAK 137
           DP   Y  K
Sbjct: 142 DPAQIYAEK 150


>UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria
           RepID=HIS3_BIFLI
          Length = 136

 Score =  155 bits (393), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 44/105 (41%), Positives = 63/105 (60%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
               GL+  ++Q   + EVLM+GYMN EAL +TL +G+VTF+SR++Q  W KG+TSG+  
Sbjct: 22  RDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQ 81

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
            V  ++ DCD D LLV  + +G  CH G  SCF +     +    
Sbjct: 82  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 126


>UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides
           RepID=Q03VY1_LEUMM
          Length = 132

 Score =  155 bits (392), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 49/125 (39%), Positives = 70/125 (56%), Gaps = 2/125 (1%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M+  +   + + +  +GL+P ++  A +   LMLGYMN E+   T  +G+  F+SR +Q 
Sbjct: 1   MIGTE--PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQE 58

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGETSGN   VVS+  DCD DTLL+  NP GP CH    SCF +T          + 
Sbjct: 59  LWHKGETSGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQA 118

Query: 121 LLAER 125
            +A +
Sbjct: 119 TIANK 123


>UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii
           'Deep ecotype' RepID=B4RV64_ALTMD
          Length = 133

 Score =  155 bits (392), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 46/112 (41%), Positives = 68/112 (60%), Gaps = 1/112 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   EL+++  DGL+PVI Q   S +VLM  +M+ E+LD+TL +GK+ ++SR++Q LW 
Sbjct: 20  DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL 115
           KG +SG+   V SIA DCD D LL   + +G  CH    SCF     +    
Sbjct: 79  KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFYLRFWEDKVT 130


>UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae
           RepID=HIS3_METS3
          Length = 132

 Score =  154 bits (390), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 42/132 (31%), Positives = 67/132 (50%), Gaps = 5/132 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
             R E++ +K    +  I Q   +G++LM+  MN +AL KT+E+GK  ++S ++   W K
Sbjct: 4   NFRHEINGQKV---ITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SG+   V  I  DCD D +++     G  CH+G  SCF    +        E+ L  
Sbjct: 61  GESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLET 120

Query: 125 --RKSADPETSY 134
              K  +P+  Y
Sbjct: 121 ILEKVFNPDDVY 132


>UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms
           RepID=C7NRL7_HALUD
          Length = 138

 Score =  154 bits (390), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 49/126 (38%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +L +E  + L P + Q A SG+VLML Y+  EALD+T E+G   ++SR++  LW KGETS
Sbjct: 22  DLAFEDNEYL-PAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETS 80

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           GN  ++  I  DCD D LL +    G  CH G  SCF  T         ++  +   +  
Sbjct: 81  GNVQHLKEIRVDCDGDALLYVIEQDGGACHTGFQSCFHRT---------IDGEVVGERVF 131

Query: 129 DPETSY 134
           DP+  Y
Sbjct: 132 DPDDVY 137


>UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria
           RepID=HIS3_BACCN
          Length = 101

 Score =  153 bits (386), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 43/94 (45%), Positives = 61/94 (64%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P IV +  + EVLML YMN EA +KTL++ K  F+SR++Q LW KG TSG+  +V
Sbjct: 6   SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            S+  DCD D +++  N +G  CH G  +CF   
Sbjct: 66  KSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99


>UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium
           amycolatum SK46 RepID=UPI000185C2AA
          Length = 132

 Score =  153 bits (386), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 41/103 (39%), Positives = 59/103 (57%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                 +     DGL+P IVQ   +G VLM+ +M+  AL  T+ + + T++SR++   W 
Sbjct: 23  PADIANIAKFNADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWI 82

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           KG TSG+F  V S+A DCD DT+L+     G  CH G+ SCF 
Sbjct: 83  KGLTSGHFQTVTSLALDCDGDTVLMQVVQDGAACHTGSHSCFD 125


>UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA
          Length = 126

 Score =  152 bits (385), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 41/105 (39%), Positives = 59/105 (56%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P I Q A +G VLML +MN EA D+T+   +  +FSR++ +LW KG+TSG+   V  I
Sbjct: 21  LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
             DCD DT+L+     G  CH+   SCF          +  E+ +
Sbjct: 81  RVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERI 125


>UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria
           RepID=C7RQA3_9PROT
          Length = 142

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 40/110 (36%), Positives = 64/110 (58%), Gaps = 1/110 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +   EL +++  GL+  I Q   + E+LML +MN  A+++TL +G   ++SR+++ +W K
Sbjct: 18  EVLDELAFDQ-QGLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           GETSG    V+    DCD D +L+L + +G  CH G SSCF +       
Sbjct: 77  GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRNGRV 126


>UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13
           RepID=B6BVA2_9PROT
          Length = 129

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 51/131 (38%), Positives = 76/131 (58%), Gaps = 6/131 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               ++ W    GL+P I+Q   S +V+M+ +MN EAL KT+E+ +  F+SR++ ++W K
Sbjct: 2   NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE SGNF NVVSI  DCD D+LLV  N   G +CH G +SCF +          + + + 
Sbjct: 61  GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120

Query: 124 ERKSADPETSY 134
           +    DP+  Y
Sbjct: 121 K----DPKLIY 127


>UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI
          Length = 161

 Score =  152 bits (384), Expect = 7e-36,   Method: Composition-based stats.
 Identities = 47/133 (35%), Positives = 68/133 (51%), Gaps = 8/133 (6%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+PV+   A +GEVLM  YMN EAL KT+E+G+  ++SR++Q+LW KG++SG 
Sbjct: 23  KFD-CNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGL 81

Query: 71  FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLA 123
              V  +A D D D L +       G +CH G  SCF                       
Sbjct: 82  VQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTE 141

Query: 124 ERKSADPETSYTA 136
             K+ DP+T Y  
Sbjct: 142 TEKTFDPKTVYGN 154


>UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41B27
          Length = 137

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 9/136 (6%)

Query: 9   ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           EL++    G   L+  + Q   + +VLM+ +MN EA+++TL++ K  ++S ++Q+ W KG
Sbjct: 2   ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL---- 121
           E+SGN   V  +  DCD D +++  + IG  CH+G  SCF            L+ L    
Sbjct: 62  ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDED 121

Query: 122 --LAERKSADPETSYT 135
             +   +  DP+  Y 
Sbjct: 122 ISIISERLFDPKEMYG 137


>UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RPU9_FIBSS
          Length = 116

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 51/116 (43%), Positives = 68/116 (58%), Gaps = 5/116 (4%)

Query: 1   MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57
           M  E   +E+ +E   G   L P IVQ A  G+VLM+ +MN EAL +T E G++ F+SR+
Sbjct: 1   MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60

Query: 58  KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111
           ++  W KG+TSGN + VV  A DCD+D LL      GP   CH G  SCF  T  +
Sbjct: 61  RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116


>UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_MESSB
          Length = 139

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 44/100 (44%), Positives = 61/100 (61%), Gaps = 3/100 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+  +V  A  G +LM+ +MN EAL KTLE+G   ++SR++  LW KGETSGN
Sbjct: 27  RFD-ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGN 85

Query: 71  FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDT 108
             +V SI+ DCD D +L+       G TCH G  SCF   
Sbjct: 86  LQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRN 125


>UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae
           RepID=HIS3_PYRCJ
          Length = 128

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 38/101 (37%), Positives = 60/101 (59%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
           + L++    G +  +VQ   +GEVLM+G+M+P A+  TL +G   ++S +++R+W KGET
Sbjct: 17  KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           SG++  V     DCD D +++    IG  CH G  SCF   
Sbjct: 77  SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSP 117


>UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter
           necessarius RepID=B1XSV4_POLNS
          Length = 140

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 2/103 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W    GL+PVI Q   S ++LM+ +MN +AL +TL  G+  +++R++Q+LW K
Sbjct: 21  SWLDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHK 79

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106
           GE SG+   V  I  DCD DT+L+L     G  CH G  SCF 
Sbjct: 80  GEESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122


>UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G191_ABIDE
          Length = 295

 Score =  149 bits (376), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 49/113 (43%), Positives = 66/113 (58%), Gaps = 1/113 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+P IVQ   +G VL + YMN E+L+ TL      F+SR+++ LW KGE
Sbjct: 18  IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           TSGN+ +VVSI  DCD D LLV     G  CH+G  SCF DT         +E
Sbjct: 77  TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDTMKIEFEENIME 129


>UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales
           RepID=HIS3_MYCBP
          Length = 115

 Score =  148 bits (375), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 41/107 (38%), Positives = 63/107 (58%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +         DGL+  +VQ   SG+VLM+ +MN EAL +TL++ + T++SR++  
Sbjct: 1   MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107
            W KG TSG+  +V S+  DCD D +L+  + +G  CH G  SCF  
Sbjct: 61  QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDA 107


>UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/
           phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus
           Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT
          Length = 127

 Score =  148 bits (375), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 44/130 (33%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           Q   +L +    GL+P ++  A  G+ L L YMN +A+ KT+E+GK+  F R++ RL  K
Sbjct: 2   QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GETSG+  +V  I  DC+ ++L+ +       CH G  SC+                + E
Sbjct: 61  GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQTNSI----QVVE 116

Query: 125 RKSADPETSY 134
            K  DPE  Y
Sbjct: 117 EKVFDPENVY 126


>UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1
           RepID=A3WCC9_9SPHN
          Length = 143

 Score =  148 bits (375), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 47/98 (47%), Positives = 65/98 (66%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  + + EVL++ +MN +AL KT E+GKV F+SR++  LW KGETSGN
Sbjct: 32  KFD-ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGN 90

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L+V  I  DCD D L++ A P GPTCH G +SCF   
Sbjct: 91  VLSVDEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128


>UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales
           RepID=HIS3_ERYLH
          Length = 125

 Score =  147 bits (372), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 45/98 (45%), Positives = 63/98 (64%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++ +DGL+  +VQH  + EVLM+ +MN +ALD T ++G   FFSR++Q LW KG TSGN
Sbjct: 18  KFD-SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGN 76

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L V  +  DCD D +++L  P GP CH G  +CF   
Sbjct: 77  TLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE 114


>UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P0M4_9BACE
          Length = 108

 Score =  147 bits (371), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 50/97 (51%), Positives = 71/97 (73%), Gaps = 1/97 (1%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           ++K++ L+PVI+Q A + EVLMLG+ N EA++ TL++    F+SR++Q+LW KGETSG+F
Sbjct: 8   FQKSE-LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHF 66

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           L+V  +  DCD DTLL   +P+GPTCH G  SCF   
Sbjct: 67  LHVERMVTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103


>UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ
          Length = 149

 Score =  146 bits (369), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 50/133 (37%), Positives = 68/133 (51%), Gaps = 19/133 (14%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+P IV  A SG VLM  +MN +AL +T+ +G   F+SR++ +LW KGE SGN L+V
Sbjct: 29  SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88

Query: 75  VSIAPDCDNDT--LLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
             +  DCD D   LL      G  CH G  SCF                   R  A P++
Sbjct: 89  KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR-----------------RLIASPDS 131

Query: 133 SYTAKLYASGTKR 145
           S +  L ++G   
Sbjct: 132 SGSLSLESAGLPL 144


>UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae
           RepID=HIS3_ZYMMO
          Length = 124

 Score =  145 bits (365), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 36/102 (35%), Positives = 61/102 (59%), Gaps = 1/102 (0%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           W+   GL+  ++  A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ 
Sbjct: 15  WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           + +  I  DCD DTL +   P+GP CH G  SCF        
Sbjct: 74  MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVEDGH 115


>UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris
           BL2 RepID=B8EQR3_METSB
          Length = 141

 Score =  144 bits (364), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 42/106 (39%), Positives = 57/106 (53%), Gaps = 2/106 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+  + + A  GE+LM+ YMN EAL  TL +G+  ++SR++Q +W KG TSG    V
Sbjct: 30  PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89

Query: 75  VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
             I  DCD D LL  + A   G  CH G  SCF     +      +
Sbjct: 90  REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYRRLSETGDGETV 135


>UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum
           ATCC BAA-798 RepID=D1CF76_THET1
          Length = 300

 Score =  141 bits (355), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 48/132 (36%), Positives = 76/132 (57%), Gaps = 8/132 (6%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W K
Sbjct: 9   NLVDMLQYD-EHGLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLK 67

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GETSG  L+V  + P+C+ ++LL+L +   P  CH G  SCF         +        
Sbjct: 68  GETSGRTLHVRELRPNCELNSLLILVDQRLPGACHTGHFSCFYRRLEDGELVE------I 121

Query: 124 ERKSADPETSYT 135
           E    DPE  Y+
Sbjct: 122 EPPLFDPEDVYS 133


>UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001744401
          Length = 141

 Score =  139 bits (351), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 2/115 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  DGL+P I     + E LM+ YMN E L  T+  G+  ++SR+++ +W KG+TSG 
Sbjct: 28  KFD-ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGE 86

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           F  V  I  DCD D +++    +G   CH    +CF               L+  
Sbjct: 87  FQVVKEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRKVDLENVTAGPVPLVRA 141


>UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales
           RepID=HIS3_METVS
          Length = 136

 Score =  135 bits (341), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 3/105 (2%)

Query: 6   QRRELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           Q  +L + K D   L+  I        VLM  +M+ E+L  TL++G + +FS ++ ++W 
Sbjct: 17  QNMDLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWM 75

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           KGE S N   V+ +  DCD D LL +    G  CH+G  SCF + 
Sbjct: 76  KGEESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNK 120


>UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HIS3_IGNH4
          Length = 129

 Score =  134 bits (337), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 36/106 (33%), Positives = 59/106 (55%), Gaps = 1/106 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             ++    L++   D  +  + Q   SG+VLM+  MN EA+ KTL +G V ++S++++ L
Sbjct: 8   EAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKEL 67

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFG 106
           W KG TSG+   +     DCD D++L++        CH+G  SCF 
Sbjct: 68  WVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFH 113


>UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC
           23134 RepID=A1ZDC3_9SPHI
          Length = 130

 Score =  131 bits (331), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 47/116 (40%), Positives = 66/116 (56%), Gaps = 7/116 (6%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           +EK  GL+PV+VQ   SG+VLMLGY N  AL +TL++G  TF+S ++  LWTKG+TSG++
Sbjct: 15  FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74

Query: 72  LNVVSIAPDCDNDTLLVLANPIGP-TCHK------GTSSCFGDTAHQWLFLYQLEQ 120
           L +  I  DCD D L+     +G   CH          SCF         L  +++
Sbjct: 75  LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCFYRKMASGKTLEFIDK 130


>UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58
           RepID=Q1NG03_9SPHN
          Length = 157

 Score =  130 bits (328), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 5/128 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GLMP IV +A    VLMLGYMN EAL +TL + +  F+SR+++ LW KGE SG 
Sbjct: 22  RFD-AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGF 80

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQL---EQLLAERK 126
              V  +  D D D L+++     P +CH G  SCF       +   +     + +    
Sbjct: 81  RQRVDHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDKSPVRLRRIEREA 140

Query: 127 SADPETSY 134
           + D +T Y
Sbjct: 141 AFDAKTVY 148


>UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI0001910D6A
          Length = 157

 Score =  129 bits (325), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 74/81 (91%), Positives = 77/81 (95%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR
Sbjct: 77  MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136

Query: 61  LWTKGETSGNFLNVVSIAPDC 81
           LWTKGETSG+ LNVVSIAPDC
Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157


>UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira
           RepID=HIS3_LEPIN
          Length = 187

 Score =  127 bits (320), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 13/133 (9%)

Query: 9   ELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
            LD++KT          L+PV+      G++LM  + N E+   +L++G   +FSR++ +
Sbjct: 60  PLDFQKTTELLLTGKKNLVPVVAIDLQ-GQILMQAFGNEESQTLSLKTGYAHYFSRSRNQ 118

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG+TSG+   ++ I    D   L+         CH+G  SCF     +        +
Sbjct: 119 LWKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERME----GVTWK 174

Query: 121 LLAERKSADPETS 133
           LL   ++  PE S
Sbjct: 175 LLPVPRNFLPEKS 187


>UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae
           RepID=HIS3_SULSO
          Length = 85

 Score =  124 bits (313), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 35/79 (44%), Positives = 49/79 (62%)

Query: 33  MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92
           M+G MN EAL KTL +G + F+S ++++LW KGETSGNF  +     DCD D +L     
Sbjct: 1   MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60

Query: 93  IGPTCHKGTSSCFGDTAHQ 111
           +GP CH G  +CF  +  +
Sbjct: 61  LGPICHTGNYTCFYRSYDE 79


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  123 bits (310), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 39/137 (28%), Positives = 66/137 (48%), Gaps = 14/137 (10%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            ++ ++ DCDND +  +    G  CH     CFG+       + +LE+ L  RK + PE 
Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNL----TGIARLEKTLKARKESAPEG 221

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA+L+ +  K +  K+ EE  E   A     + ++  EA+DL+Y  L      G+ + 
Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDA---KTKEDVAFEAADLIYFALTKAVSAGVSVA 277

Query: 193 TVIENLR------KRHQ 203
            + ++L       KR +
Sbjct: 278 DIEKSLDAKGWKVKRRK 294


>UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa
           serovar Patoc RepID=B0SHA6_LEPBA
          Length = 202

 Score =  119 bits (298), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 1/108 (0%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           +    L P + Q  ++G+ LML +   E+L   +ESG  T+FSR++   W KGE SG+F 
Sbjct: 89  DSMPPLSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQ 147

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
            +  I    +   +  + + IG  CH G  SCF     Q   +  +  
Sbjct: 148 KLKQIYVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYS 195


>UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7
           genomosp. GTL1 RepID=A5KSK8_9BACT
          Length = 125

 Score =  117 bits (294), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 47/103 (45%), Positives = 59/103 (57%), Gaps = 7/103 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +D +  + L+   V       V       M GYMN  A++ TL  G VTFFSRT  +LW 
Sbjct: 20  VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79

Query: 64  KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           KGETSGN L +   I  DCD D+LL+ A P+G TCH G+ SCF
Sbjct: 80  KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCF 122


>UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD
          Length = 101

 Score =  116 bits (291), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+PV+V    SG++LML Y +   L+ T  +G   ++SR++Q +W KG +SG    V ++
Sbjct: 7   LLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQLVQAV 66

Query: 78  APDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAH 110
             DCD D L   VL    G  CH    SCF     
Sbjct: 67  YRDCDGDALNFRVLVLGDGRVCHTRQVSCFHTRLW 101


>UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms
           RepID=HIS2_PELTS
          Length = 98

 Score =  116 bits (290), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 34/95 (35%), Positives = 50/95 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
             +   +  L +++ +R+   P+ SYTA L+  G  +I +K+GEE  E  +AA       
Sbjct: 1   MGEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAA 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E +DL+YHLLVLL   GL    V+  L  R Q
Sbjct: 61  LVGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95


>UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria
           RepID=HIS2_CLOB1
          Length = 110

 Score =  115 bits (288), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 32/95 (33%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            ++   +  L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   D  E
Sbjct: 1   MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  DL YH++VL+ ++ + L  + + L KR +
Sbjct: 61  LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95


>UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=A6LT24_CLOB8
          Length = 108

 Score =  113 bits (282), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 48/90 (53%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L + + +RK+   E SYT  L+  GT +I +KVGEE  E  ++   +++ E  NE
Sbjct: 3   ENIKALYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             DL YHLLVL+    + +  V   L KR 
Sbjct: 63  ICDLTYHLLVLMAQMNISIEEVGAELEKRR 92


>UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria
           RepID=HIS2_LEPBJ
          Length = 92

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 48/91 (52%), Positives = 61/91 (67%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             FL QLE +L +RK   P+ SYTA L+  G  RI +KVGEE  E  +AA   D+ ELT+
Sbjct: 1   MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+DL++HL VLL +Q L L  V+E LRKRH
Sbjct: 61  EAADLLFHLQVLLVEQELSLQDVVEELRKRH 91


>UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium
           RepID=HIS2_CLONN
          Length = 110

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/95 (30%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 + +L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   ++ +
Sbjct: 1   MDNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDD 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  D++YH++VL+ ++ + L  +   L KR +
Sbjct: 61  LIAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95


>UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes
           RepID=HIS2_BACC2
          Length = 107

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 28/90 (31%), Positives = 49/90 (54%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                L + + ERK +    SYT  L++ G  +I +K+GEE  E  +A   +D+ E+  E
Sbjct: 3   NAFKLLYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             D+ YH  VLL ++ + L  V+  +++R+
Sbjct: 63  MVDVFYHCFVLLAEKNIALEDVMREVKERN 92


>UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5
          Length = 105

 Score =  111 bits (278), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 51/90 (56%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L  ++ +RK    + SYT  L+  G  +I +KVGEE  E  +A+   ++ +   E 
Sbjct: 1   MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            DL+YH+LVL+ ++ + L  + + L KR Q
Sbjct: 61  CDLIYHVLVLMANENITLEELRKELEKRRQ 90


>UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria
           RepID=HIS2_MAGSA
          Length = 109

 Score =  110 bits (276), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 42/92 (45%), Positives = 56/92 (60%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +L  ++A RK  DP+ SYTAKL+A G  +IAQK GEE VET +AA    + EL
Sbjct: 3   QDSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDEL 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++D +YHLLVL  D G++   V   L +R
Sbjct: 63  VGESADTLYHLLVLWADCGVEPAKVWAELARR 94


>UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales
           RepID=HIS2_BORA1
          Length = 116

 Score =  110 bits (275), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 28/74 (37%), Positives = 38/74 (51%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP+TSY AKL A G     +K+GEE  E  +AA       + +E +DL +H LV L    
Sbjct: 29  DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88

Query: 189 LDLTTVIENLRKRH 202
           L    V+  L +R 
Sbjct: 89  LRPEDVLAELARRE 102


>UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum
           ATCC 11170 RepID=HIS2_RHORT
          Length = 117

 Score =  109 bits (274), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 36/89 (40%), Positives = 52/89 (58%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L  ++A R+ ADP TSYTAKL+  G  +I QK GEE  E  +AA V    ++  E
Sbjct: 15  EIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAE 74

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           ++D++YHL+VL  D G+    V   L +R
Sbjct: 75  SADVLYHLMVLWADVGVTPDRVWAELARR 103


>UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria
           RepID=HIS2_NITMU
          Length = 121

 Score =  109 bits (273), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 34/94 (36%), Positives = 49/94 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 L++L + +  RK +DP  SY AKL   G  +I +K+ EE  E  LA+   D   
Sbjct: 1   MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  E +DL +H LVLL    L L  V++ LR+R 
Sbjct: 61  VVRETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94


>UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria
           RepID=HIS2_NEIG1
          Length = 107

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 32/93 (34%), Positives = 48/93 (51%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  ++Q + +RKSADP  SY A+L   G  +I +KV EE  E  +A+   D   L
Sbjct: 1   MGDSVLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             E +DL +H ++LL    L    V++ L +R 
Sbjct: 61  VYEVADLWFHTMILLTHHDLKAEDVLDELSRRQ 93


>UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei
           group RepID=HIS2_LACCB
          Length = 110

 Score =  108 bits (270), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 29/94 (30%), Positives = 45/94 (47%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 +  L   + ER++     SYT  L+  G  +I +KVGEE  E  +AA   D   
Sbjct: 2   TQAKQSIPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPA 61

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
              E +DL YH+LVL+ ++G+ +  +   L  R 
Sbjct: 62  FILEVADLTYHVLVLMVERGITVDQIATELASRE 95


>UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria
           RepID=HIS2_GRABC
          Length = 160

 Score =  108 bits (270), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 35/96 (36%), Positives = 56/96 (58%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           D  +    L +L +++ +R+ ADP  S++A+L + G  ++AQK GEE VE  + A   D+
Sbjct: 38  DPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLVL    G++   V   L KR 
Sbjct: 98  EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133


>UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KWI3_HALNC
          Length = 124

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 44/95 (46%), Positives = 60/95 (63%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
            T +    L QL  ++ +RK ADP +SY A+L+A G  +IAQKVGEEGVE ALAA   D 
Sbjct: 2   ATNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDN 61

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             + +E +DL +H +VLL D GL    V++ L +R
Sbjct: 62  VAIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96


>UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms
           RepID=HIS2_ALHEH
          Length = 109

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/91 (39%), Positives = 50/91 (54%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           Q   L  L ++L ER+ ADP TSY AKL+  G   I +KVGEE  E  +AA   DR ++ 
Sbjct: 4   QRDILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVI 63

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +DL +H L++L         V+  L +R
Sbjct: 64  YETADLWFHSLIMLSACDAGPDDVLAELERR 94


>UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZNB1_9GAMM
          Length = 125

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 31/82 (37%), Positives = 50/82 (60%)

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           +++ +R+ ADPE SY AKL+A G   + +K+GEE  ET +A    D   L +E +DL +H
Sbjct: 20  EVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKNDDSDALVSEMADLWFH 79

Query: 180 LLVLLQDQGLDLTTVIENLRKR 201
            L++L  +G     V++ L +R
Sbjct: 80  SLIVLAARGRHPDDVLDELARR 101


>UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales
           RepID=B0MMD1_9FIRM
          Length = 114

 Score =  107 bits (268), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 37/99 (37%), Positives = 58/99 (58%), Gaps = 5/99 (5%)

Query: 110 HQWLFLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
            +     ++ +++  RK+       PE SYT  L+  G  +I +KVGEE  ET +AA   
Sbjct: 1   MKMTVYEEIFEVIKARKAQYDAGNAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNA 60

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           D  EL NE +DL+YH++VL  D+GL+ + V E L +R++
Sbjct: 61  DNDELKNEINDLLYHVMVLCADRGLEWSEVEEVLSERNE 99


>UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=A4EBZ9_9ACTN
          Length = 105

 Score =  106 bits (264), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 31/103 (30%), Positives = 49/103 (47%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G  +      +    L  L +++  R+ A P+ SYTA+L       + +K+ EE  E  +
Sbjct: 2   GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61

Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A   +D   +  EA DL+YHLLV L+  G+ L  +   L  R 
Sbjct: 62  ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARR 104


>UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales
           RepID=HIS2_LEUMM
          Length = 114

 Score =  106 bits (264), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 1/92 (1%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +   ERK      SYT  LY  G  +I +KVGEE  E  L A  ++  EL
Sbjct: 1   MPQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EEL 59

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E SDL++HL+VLL ++G+ L  + + L  R
Sbjct: 60  IYETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91


>UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=HIS2_UNCMA
          Length = 95

 Score =  106 bits (264), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 2/93 (2%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELT 170
             L ++  ++A+RK    E SYT  LY    G  ++ +K+GEE  E  +AA      E+ 
Sbjct: 3   DVLDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIV 62

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +E +DL +H +VLL  + +    + E   +R +
Sbjct: 63  SECADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95


>UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria
           RepID=HIS2_MAGSM
          Length = 252

 Score =  106 bits (264), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 39/99 (39%), Positives = 52/99 (52%), Gaps = 2/99 (2%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
                     L Q+ Q++ +RKSA DPE SY AKL+  G   I +KVGEE  E  LA   
Sbjct: 3   NLSPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKG 62

Query: 164 H-DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              R E+ +EA+DL++H LV L    +  T V+  L  R
Sbjct: 63  RAARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101


>UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria
           RepID=HIS2_ACIAC
          Length = 137

 Score =  105 bits (263), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 33/112 (29%), Positives = 47/112 (41%), Gaps = 7/112 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSA---DPETSYTAKLYASGTKRIAQKVGEEG 154
           H   S       H    L +L  ++  RK A   D + SY A+L   G     +K+GEE 
Sbjct: 3   HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62

Query: 155 VETALAATVHDRFE----LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            E  +AA   D       L  E +DL +H ++ L   GL    V+  L +R 
Sbjct: 63  TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114


>UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria
           RepID=HIS2_HALHL
          Length = 114

 Score =  105 bits (262), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 31/97 (31%), Positives = 50/97 (51%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                     L  L + + +R+ A  +TSY A+L+  G   I +KVGEE  E  +AA   
Sbjct: 4   AASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGG 63

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +R ++  E +DL +H LV+L   G+ +  V+  L +R
Sbjct: 64  EREQVVYETADLWFHTLVMLSASGVSVDEVLAELERR 100


>UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria
           RepID=HIS2_ACICJ
          Length = 133

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 34/96 (35%), Positives = 53/96 (55%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
             A     L +L   +  RK+ADP  S++A+L + G  ++AQK GEE VE  + A   +R
Sbjct: 14  PAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNR 73

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLV+    G+    V   L++R 
Sbjct: 74  TALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109


>UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1
           Tax=Raoultella terrigena RepID=Q6U8A9_KLETE
          Length = 88

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 71/83 (85%), Positives = 75/83 (90%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL
Sbjct: 6   LLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHL 65

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +VLLQDQ L L  +I NL+ RHQ
Sbjct: 66  MVLLQDQELSLQDIIANLKSRHQ 88


>UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM
           10642 RepID=C8SBH0_FERPL
          Length = 92

 Score =  104 bits (261), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
            L +L++++ ERK      SYTAKL     G  ++ +K GEE VE  LA    D+  +  
Sbjct: 1   MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EA+DL+YH +VLL    + +  V + LR+R +
Sbjct: 61  EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92


>UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BVA1_9PROT
          Length = 104

 Score =  104 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 36/90 (40%), Positives = 59/90 (65%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
              L +L+QL+  +K +DP  SYTAKL++ G + I +K GEE +E  +A+   ++  + N
Sbjct: 1   MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           E++D++YHLLVLL ++ + L  VI  L +R
Sbjct: 61  ESADVLYHLLVLLSEKSVTLKEVISELERR 90


>UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis
           RepID=HIS2_ZYMMO
          Length = 107

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 43/93 (46%), Positives = 57/93 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  +E ++AER+ A PE SY + L+  GT  IAQKVGEE VET +AA   D+  L
Sbjct: 1   MSEETLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +EA+DL++HL VLL D+G     V   LR+R 
Sbjct: 61  ESEAADLIFHLAVLLADRGSSFENVFSELRRRE 93


>UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei
           RepID=HIS2_IGNH4
          Length = 102

 Score =  104 bits (259), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/91 (37%), Positives = 54/91 (59%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
            FL +L  ++ +R    P+ SYTA++   G    A+K GEE VE  +A+    R  +  E
Sbjct: 3   DFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D++YHL+VLL  +G+D   VI+ L +R +
Sbjct: 63  AADVIYHLMVLLALRGVDWAEVIKELERRSR 93


>UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria
           RepID=HIS2_BURCC
          Length = 121

 Score =  104 bits (259), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV---- 163
           T      L +L  ++  RK  DP+ SY ++L+  G   + +K+GEE  E  LAA      
Sbjct: 2   TQSTEDTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQG 61

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                L  E +DL +H LV+L    L    VI  L +R 
Sbjct: 62  GAPTALVGEVADLWFHCLVMLSHFDLSPADVIAELERRE 100


>UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ
          Length = 127

 Score =  103 bits (257), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 37/96 (38%), Positives = 53/96 (55%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
            +       L +L  L+  R+S   + SYTA+L  +G +R A+K GEE VET +AA   D
Sbjct: 15  KEFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSD 74

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              L  EA+D +YHLLVLL+ + +    V+  L  R
Sbjct: 75  ASALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110


>UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SM22_9BACT
          Length = 100

 Score =  103 bits (256), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 28/92 (30%), Positives = 51/92 (55%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +++ ERK+   + SYT +L   G+ +I +K+GEE  E   A    D  ++
Sbjct: 1   MNVEIIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E +DL+YHL+V L+ + +    V+  L++R
Sbjct: 61  AGETADLLYHLIVALEFRNVQFEDVLGVLQER 92


>UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae
           RepID=HIS2_METBF
          Length = 104

 Score =  102 bits (254), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 51/90 (56%), Gaps = 2/90 (2%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            ++ +++ +RK    E SY  KL     G  +I +KVGEE +ET LA    +  E+ +E+
Sbjct: 10  NRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNENHEEIVSES 69

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           SDL++HLLV+L    + L  +   L  RH+
Sbjct: 70  SDLIFHLLVMLAANNVTLDEIAAELSARHE 99


>UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales
           RepID=HIS2_METB6
          Length = 104

 Score =  102 bits (254), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGV 155
           H+G              + +L  ++ ER     E SYT++L     G  ++ +KVGEE  
Sbjct: 3   HEGKEPV------DLRVIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEEST 56

Query: 156 ETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           E  LA         T EA+DL +H+LV L+   +DL+ VI  L +R +
Sbjct: 57  EFILAVKNGVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104


>UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria
           RepID=HIS2_NITWN
          Length = 116

 Score =  101 bits (253), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 36/96 (37%), Positives = 51/96 (53%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
                Q   ++ L  ++  R ++  + SYT KL   G    A+K+GEE VET +AA   D
Sbjct: 6   SRRIMQRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKD 65

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           R  L  E +DLM+H LVLL+  G+ L  V   L +R
Sbjct: 66  RHHLIAEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101


>UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae
           RepID=HIS22_BRAJA
          Length = 134

 Score = 99.5 bits (247), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 46/90 (51%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L   +   +  DP TS TA+L+  G  ++A+K+ EE +E  + A   D   +  E
Sbjct: 3   DSLERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++DL+Y+L VL    G+    V   + +R 
Sbjct: 63  SADLLYNLTVLWASAGVRPEDVWREMTRRE 92


>UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TJZ9_9PROT
          Length = 104

 Score = 99.2 bits (246), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 50/91 (54%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             + +L + +   ++  P  S TA+L   G  +IA+KV EE  E AL A V DR  +  E
Sbjct: 3   HPIDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           ++DL+Y+L+VL    G+  + V   + +R +
Sbjct: 63  SADLLYNLMVLWVWMGITPSEVWAEMEQREK 93


>UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum
           hungatei JF-1 RepID=Q2FUB9_METHJ
          Length = 91

 Score = 98.8 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 50/90 (55%), Gaps = 2/90 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + ++  ++ ER +   E SYT+K+     G  +  +K+GEE  E  +A    D+  ++ E
Sbjct: 1   MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL++H ++ L+  G+ L +V + L+ R 
Sbjct: 61  GADLLFHFMLALKRSGVTLQSVWDELQSRR 90


>UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing
           symbionts RepID=HIS2_VESOH
          Length = 105

 Score = 98.8 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 30/85 (35%), Positives = 48/85 (56%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +LEQ+L +RKSA  + SY + LY  GT  I +K+ EE  E  +A       ++  E +DL
Sbjct: 7   KLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEIADL 66

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
            +H LVLL+ + + +  +   L +R
Sbjct: 67  WFHTLVLLRFKKIKVEQITNELSRR 91


>UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria
           RepID=HIS2_BRUA1
          Length = 107

 Score = 98.4 bits (244), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  LE+++AER S    TSYTA L A G  + AQK+GEE VET +AA   DR  +
Sbjct: 1   MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +E++DL+YHL V+    G+ L  V++ L++R
Sbjct: 61  VSESADLLYHLAVVWNIAGVALEDVLQELQRR 92


>UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales
           RepID=HIS2_MESSB
          Length = 112

 Score = 98.4 bits (244), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 36/92 (39%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE ++AER ++    S+TA+L ++G  + A+K+GEE VET +AA   D+  L
Sbjct: 1   MNEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKAL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++DL+YH LV+L+  G+ L  V+  L  R
Sbjct: 61  IAESADLVYHWLVVLKIAGVRLDEVMLELESR 92


>UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae
           RepID=Q2CDY7_9RHOB
          Length = 106

 Score = 97.2 bits (241), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 34/82 (41%), Positives = 50/82 (60%), Gaps = 1/82 (1%)

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + +A RK ADP+ S+TA+L AS  +  A+K GEE VE  + A   DR  L +EA+D++YH
Sbjct: 8   ETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSEAADVIYH 66

Query: 180 LLVLLQDQGLDLTTVIENLRKR 201
           LLV+     + L  +   L +R
Sbjct: 67  LLVMCAVNDITLADIERELERR 88


>UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis
           HTCC2503 RepID=A3VQS9_9PROT
          Length = 109

 Score = 97.2 bits (241), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 38/89 (42%), Positives = 48/89 (53%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L   +  RK AD   SYTA L   G  R A+K GEE VE ALA  +  R +L  E 
Sbjct: 7   TLERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAET 66

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +D++YHL VLL    LD + +   L KR 
Sbjct: 67  ADVLYHLAVLLAANELDWSDISAALTKRE 95


>UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae
           RepID=HIS2_NATPD
          Length = 101

 Score = 96.9 bits (240), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 38/98 (38%), Positives = 55/98 (56%), Gaps = 2/98 (2%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVH 164
           D       L +L +++  RK   P+ SYTA L+    G   + +K+GEE  E  LAA   
Sbjct: 4   DGHDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDD 63

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           D  EL +EA+D++YHLLVLL  + ++L  +   LRKR 
Sbjct: 64  DDEELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101


>UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae
           RepID=A4SV22_POLSQ
          Length = 133

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%)

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV--------HDRFELTNEASDLMY 178
           SADP+TSYTA L++ G   I +K+GEE  E  +AA            +  L  E +DL +
Sbjct: 33  SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L+ L    L    VI  L +R
Sbjct: 93  HCLIALSQFNLRPEDVIAELDRR 115


>UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota
           RepID=HIS2_META3
          Length = 96

 Score = 94.9 bits (235), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 4/96 (4%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRF 167
              L +  +++ +R    PE SY A L  +       +I +KVGEE  ET LAA   D+ 
Sbjct: 1   MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ 60

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EL  E++DL++H+LVLL + G++   ++E   +R +
Sbjct: 61  ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK 96


>UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp.
          HTCC2601 RepID=Q0FX88_9RHOB
          Length = 164

 Score = 93.4 bits (231), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 30/65 (46%), Positives = 39/65 (60%)

Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           DGLMP     A SGE+LMLG+M  EA   T+E+G+  +FSR +Q LW +G  SG  L +
Sbjct: 12 PDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKL 71

Query: 75 VSIAP 79
          V    
Sbjct: 72 VEARI 76


>UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis
           RepID=HIS2_SPHAL
          Length = 109

 Score = 93.0 bits (230), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 39/91 (42%), Positives = 54/91 (59%), Gaps = 1/91 (1%)

Query: 113 LFLYQLEQLLAERKSADP-ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             L +LE ++ +R +A   E SY A L A G  +IAQK+GEE VE  +AA   D   L  
Sbjct: 7   ETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIG 66

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EASDL++HL +LL ++GL    +   L +RH
Sbjct: 67  EASDLVFHLSILLAERGLTWDAIAAELDRRH 97


>UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K
           RepID=B4UDK1_ANASK
          Length = 110

 Score = 92.2 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 6/90 (6%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNE 172
              + + R  A P  SYT KL A+   RI +K+ EE  E   A          +  L +E
Sbjct: 11  WATIESRRADAAPAESYTKKLLAA-PARIRRKIIEEAYEVNEAHQALLDGKDTKDHLAHE 69

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A+DL+YHL VLL    +  T V   L +RH
Sbjct: 70  AADLLYHLYVLLASADVTPTEVYGVLERRH 99


>UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB
          Length = 101

 Score = 90.7 bits (224), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
            L   + +RK+ D + SYT+ L + G  +   K+ EE  E   A   +D+  + +EA+D 
Sbjct: 7   NLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHEAADT 64

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +YH+LV L+   +    V++ L  R +
Sbjct: 65  IYHILVTLEAADIKFEDVLKELEGRKK 91


>UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae
           RepID=Q0C645_HYPNA
          Length = 120

 Score = 89.5 bits (221), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 31/104 (29%), Positives = 45/104 (43%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
              +             +  E + A     D  +S+TAKL A G    A KV EEG E A
Sbjct: 2   TAKAPLASPDRLAAALAHLAETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELA 61

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            A        + +EA+D++YH+ V L+ +G+ L  V   L  R 
Sbjct: 62  DAVRRESDDRVASEAADVIYHVFVALRSRGVALDAVAGALEARQ 105


>UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces
           RepID=HIS2_STRCO
          Length = 90

 Score = 88.8 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 26/76 (34%), Positives = 39/76 (51%)

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +  + DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V
Sbjct: 15  HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74

Query: 183 LLQDQGLDLTTVIENL 198
           ++  +G+ L  V  +L
Sbjct: 75  MMVARGISLDDVYAHL 90


>UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales
           RepID=HIS2_STRGG
          Length = 90

 Score = 88.4 bits (218), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 26/75 (34%), Positives = 38/75 (50%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +    DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V+
Sbjct: 16  KAAEGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVM 75

Query: 184 LQDQGLDLTTVIENL 198
           +  +G+ L  V  +L
Sbjct: 76  MVARGISLDDVYAHL 90


>UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani
           RepID=HIS2_CLOTE
          Length = 107

 Score = 86.8 bits (214), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
            +   L +    + + +  D   SY   L+   + +I +K+GE+  E  +A     + E 
Sbjct: 1   MEVNKLIEELVEVIKDRKNDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQ 57

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +E SDL+Y+L+VL+  Q +++  VIE L KR 
Sbjct: 58  VHEISDLIYNLMVLMMKQNIEIENVIEELGKRR 90


>UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria
           RepID=Q4JVP0_CORJK
          Length = 332

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 27/91 (29%), Positives = 38/91 (41%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
              +      L   L+ R    PE S T K   +G     +K+ EE  E  LAA      
Sbjct: 242 NEQELKTFDSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDE 301

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           EL  E S L+Y L V++  +GL    + + L
Sbjct: 302 ELAEEISQLLYWLQVVMVGRGLTPADIYKYL 332


>UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RQ70_FIBSS
          Length = 86

 Score = 84.1 bits (207), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           +   ++  L  +RK   PE   T +L+  G   I +K+ EE  E+ +AA    R     E
Sbjct: 1   MTFEEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S ++Y++ V++ ++GL L  V   L
Sbjct: 61  LSQVLYYVAVMMAEKGLTLEEVYAKL 86


>UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium
           HIMB114 RepID=D0RQN9_9RICK
          Length = 103

 Score = 83.8 bits (206), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
           +  L  L + + ERK++    SYT KL  +      +KV EE  E   A   +++    +
Sbjct: 2   FEVLEGLIKTIRERKNSSEHESYTKKLLDN-NSLCREKVMEEIKELVEAL--NEKKNEVH 58

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+D+MYH+LVLL+   + +  V+  L+KR 
Sbjct: 59  EAADVMYHILVLLEANNVKVEDVMNELKKRE 89


>UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD
          Length = 253

 Score = 82.2 bits (202), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 30/80 (37%), Positives = 50/80 (62%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ + +S +   S+T K+ A G  +I +KVGEE VE  LA    D   + +EA+D++YH+
Sbjct: 56  IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115

Query: 181 LVLLQDQGLDLTTVIENLRK 200
           L+LL   GL L T+ + +R+
Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135


>UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium
           RepID=C4L178_EXISA
          Length = 102

 Score = 82.2 bits (202), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +++LEQL+  RK    E SYT  L+  G ++IA+K GEE  E  +AA      +L  E+
Sbjct: 1   MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL+YHLLVLL  +G+ L  V   L KRH
Sbjct: 59  ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87


>UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae
           RepID=HIS2_RHOBA
          Length = 120

 Score = 81.8 bits (201), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 33/90 (36%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172
            +L   L  R +  PE SYT KL   G + I +K+ EE  E   AA   D   R     E
Sbjct: 9   DRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHAIYE 68

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A DL+YH +VL+  +G++L  V   L +R 
Sbjct: 69  AGDLIYHAMVLMAWRGIELDEVAAELARRE 98


>UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus
           Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK
          Length = 90

 Score = 81.8 bits (201), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  L +L  +RKS+  E SYT KL          KV EE  E   A   +      +E
Sbjct: 3   NTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--IHE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D+ YHLL+ L+   + +  V++ L  R +
Sbjct: 60  AADVFYHLLMYLEANDVKIEEVMQELENRKK 90


>UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae
           RepID=HIS2_METS5
          Length = 93

 Score = 81.4 bits (200), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 38/91 (41%), Positives = 55/91 (60%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L  ++A+R    PE SYTA L   G   +A+KVGEE VE  +A+    R  + +E
Sbjct: 3   DVLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            +DL+YHLLVLL  +G+ L  V + LR+R +
Sbjct: 63  TADLIYHLLVLLAMEGISLDEVRDELRRRMK 93


>UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae
           RepID=HIS2_METS3
          Length = 96

 Score = 80.7 bits (198), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 121 LLAERKSADPETSYTAKLYA----SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
            + E +  +P  SYT+K+          +I +KV EE  E  LAA       L  E+ DL
Sbjct: 12  KVLEERRDNPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND--ENLVYESVDL 69

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++H L++L  +G+++  + E   +R 
Sbjct: 70  IFHTLLILVYKGIEIDEIFEEFARRR 95


>UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis
           RepID=B9RGV5_RICCO
          Length = 193

 Score = 80.3 bits (197), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 44/105 (41%), Gaps = 7/105 (6%)

Query: 103 SCFGDTAHQWLFLYQLEQLLAERKSADPET-----SYTAKLYASGTKRIAQKVGEEGVET 157
                       LY LE  +++RK+          S+T +L       +  K+ EE  E 
Sbjct: 74  GAVQGKRLALTTLYSLESTISQRKAELAAPQEGKPSWTRRLL-DDPNLLCSKIREEADEL 132

Query: 158 ALAATVHDRF-ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                 ++      +E  D++YH +VLL  + + +  V++ LR+R
Sbjct: 133 CRTLEENEHSIHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177


>UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria
           RepID=HIS2_MYCLB
          Length = 93

 Score = 78.7 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 27/86 (31%), Positives = 35/86 (40%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                L   L+ER    P  S T      G   + +K+ EE  E  LAA    +  L  E
Sbjct: 8   KTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEE 67

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S L+Y   VL+  +GL L  V   L
Sbjct: 68  ISQLLYWTQVLMISRGLSLDDVYRKL 93


>UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZIN5_PLALI
          Length = 98

 Score = 78.4 bits (192), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 24/89 (26%), Positives = 43/89 (48%), Gaps = 3/89 (3%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172
            +LE  L  R    P  SY  +L  +G   +A  + E+  +   A    D     ++   
Sbjct: 6   KRLEAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPAA 65

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           A+++++H ++LL+  G DL+TV   L +R
Sbjct: 66  AANVLFHWMLLLKAYGHDLSTVERELMQR 94


>UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales
           RepID=Q0F926_9RHOB
          Length = 105

 Score = 77.2 bits (189), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 32/86 (37%), Positives = 55/86 (63%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L Q +  RK+   E SY ++L  SG+++ A+K GEE VE  +AA   D+  LT E++D+
Sbjct: 7   RLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEESADV 66

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++H+LV+L    +D  +V++ L +R 
Sbjct: 67  LFHMLVMLSSCDVDFKSVLKELERRE 92


>UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WMR5_EGGLE
          Length = 163

 Score = 76.4 bits (187), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 34/134 (25%), Positives = 48/134 (35%), Gaps = 35/134 (26%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
           S     ++        L   +A R+ A  E SYT +L       + +KV EE  ETALAA
Sbjct: 9   SGEMPPSSQIGATFEALAATIAARREAG-EESYTYRLLTGSLDGVLKKVMEEAGETALAA 67

Query: 162 TVHDR----------------------------------FELTNEASDLMYHLLVLLQDQ 187
              +                                     L  EA+D++YHLLV+L+  
Sbjct: 68  KDVESWACSSLAASIAASGAVDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERY 127

Query: 188 GLDLTTVIENLRKR 201
           G+ L      L  R
Sbjct: 128 GIGLDEFAAELNNR 141


>UniRef50_C0GPL2 Type III restriction protein res subunit n=1
           Tax=Desulfonatronospira thiodismutans ASO3-1
           RepID=C0GPL2_9DELT
          Length = 978

 Score = 71.4 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 19/106 (17%), Positives = 40/106 (37%), Gaps = 7/106 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVET 157
           H  +   +     +         ++ E+      +S + + +        QK+ EE  E 
Sbjct: 4   HSNSHPIYYYKLVRDKIP----SIIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYEL 56

Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             A    D+  +  E+SD++   L +L+ Q      ++  L KR +
Sbjct: 57  FTAIANGDKESVLKESSDVLEITLTILKQQNYSFDDLLAELEKRRE 102


>UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria
           RepID=HIS2_METS4
          Length = 107

 Score = 63.7 bits (154), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 59/92 (64%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  L++++  R +A P+ SYTAKL A+G  + A+K+GEE VE A+AA   DR  L
Sbjct: 1   MTAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +EA+D++YHLLV+L   G+ L  V+  L +R
Sbjct: 61  VSEAADVLYHLLVVLVGSGVALEDVMAELERR 92


>UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1
           Tax=Streptococcus mutans RepID=Q8DTR6_STRMU
          Length = 61

 Score = 59.1 bits (142), Expect = 9e-08,   Method: Composition-based stats.
 Identities = 15/46 (32%), Positives = 25/46 (54%)

Query: 157 TALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             + A   D+ E+ +E +DL+YHL V+L + G+    V   L+ R 
Sbjct: 1   MVIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46


>UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium
           longum DJO10A RepID=UPI00003932E2
          Length = 68

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 15/45 (33%), Positives = 21/45 (46%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
            V  ++ DCD D LLV  + +G  CH G  SCF +     +    
Sbjct: 19  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 63


>UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X332_DESRD
          Length = 979

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 27/56 (48%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           QK+ EE  E      V ++  +  E++D++  +L +L+  G     +I  +  R +
Sbjct: 47  QKLLEEAYELFTEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102


>UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ
          Length = 303

 Score = 54.1 bits (129), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
               ++  KV EE  E A A    D   ++ E  DL++ +  L +  G+D  T +     
Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALRDGTA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264



 Score = 39.1 bits (90), Expect = 0.089,   Method: Composition-based stats.
 Identities = 15/59 (25%), Positives = 22/59 (37%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----NLRKRH 202
           EE  E A A    D  +L +E  DL+    +H  +  +        V       L +RH
Sbjct: 60  EEAYEVADAVARGDLRDLRDELGDLLLQVVFHARMAEEQGAFAFDDVARAIGDKLVRRH 118


>UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U6I7_HYDS0
          Length = 251

 Score = 53.3 bits (127), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 16/63 (25%), Positives = 30/63 (47%), Gaps = 4/63 (6%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENL 198
            + +A+ V EE  E   A    D+  +  E +DL+    +H  +  +++  D+  V E L
Sbjct: 27  HESLAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVFELL 86

Query: 199 RKR 201
            K+
Sbjct: 87  IKK 89


>UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SG07_9BACT
          Length = 257

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 15/65 (23%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVIEN---- 197
           I     EE  E   A    D   +  E  D+ +H++   V+ +++G   +  V+      
Sbjct: 32  IKNHFMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVLNEINEK 91

Query: 198 LRKRH 202
           L +RH
Sbjct: 92  LIRRH 96



 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 11/60 (18%), Positives = 21/60 (35%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                  K  EE  E   A     + E+ +E  D+ + L+ L +   ++    +     R
Sbjct: 160 DMHGCMDKFNEEINEFKEAVATGSKDEIEHEMGDVFFSLINLSRFLKINPDEALRRANSR 219


>UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699CB9
          Length = 128

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 5  QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39
          +   ++ W+  +GL+P I Q   +G++LM+ +MN 
Sbjct: 3  EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36


>UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae
           RepID=HIS2_PYRIL
          Length = 94

 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 39/94 (41%), Positives = 54/94 (57%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE+++  R       SYT +LY+SG   +A+KVGEE VE A+AA    +  +
Sbjct: 1   MSCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRI 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             EA+DL+YHLLVLL   GL L  V   L +R +
Sbjct: 61  VEEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94


>UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RLE1_FIBSS
          Length = 265

 Score = 47.5 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 15/67 (22%), Positives = 26/67 (38%), Gaps = 8/67 (11%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENL- 198
             +   + EE  E   AA   D+  +  E  D++    +H  V  +     +  VI+ L 
Sbjct: 30  HSLLPYLVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVIQGLC 89

Query: 199 ---RKRH 202
               +RH
Sbjct: 90  EKMVRRH 96


>UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide
           pyrophosphohydrolase domain fusion protein n=1
           Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT
          Length = 258

 Score = 47.5 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A    D  EL +E  DL+    +H  +  +++   +  V 
Sbjct: 27  EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 87  QNISEKMIRRH 97


>UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria
           RepID=A8I3U9_AZOC5
          Length = 283

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 11/56 (19%), Positives = 25/56 (44%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + +  K+ EE  E + A        + +E  DL++ ++ L +  G+D    + 
Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALR 230


>UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6
           Tax=Bacteria RepID=Q3AFK8_CARHZ
          Length = 479

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----EN 197
           +   V EE  E A A    D  +L  E  DL+    +H  +  ++       V+    E 
Sbjct: 258 LLPYVLEEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVVEGICEK 317

Query: 198 LRKRH 202
           L +RH
Sbjct: 318 LIRRH 322


>UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A3P2_NATTJ
          Length = 384

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 4/54 (7%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR 199
           + EE  E   A    +   +  E  DL+    +H  V  +     L  V+  L+
Sbjct: 143 LIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVLTKLK 196


>UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D9Q9_9ACTN
          Length = 336

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 18/68 (26%), Positives = 26/68 (38%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTV---- 194
            + I + + EE  E   A    D   L  E  D++     H  + L +Q   L  V    
Sbjct: 58  HESITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVCHGL 117

Query: 195 IENLRKRH 202
            E L +RH
Sbjct: 118 AEKLIRRH 125


>UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GIZ4_9FIRM
          Length = 481

 Score = 45.6 bits (107), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D  +L  E  DL+    +H  +  ++Q      ++
Sbjct: 250 EQDHHSLKPYLLEEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIV 309

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 310 AGITEKLVRRH 320


>UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NET9_KYTSD
          Length = 144

 Score = 45.6 bits (107), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 15/61 (24%), Positives = 22/61 (36%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVIENLR----KR 201
           V EE  E   A    D   L  E  DL++    H  +  +     +  V+  L     +R
Sbjct: 42  VLEEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVVAELEAKLLRR 101

Query: 202 H 202
           H
Sbjct: 102 H 102


>UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD
          Length = 396

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 13/60 (21%), Positives = 24/60 (40%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +  K+ EE  E   A   +DR  + +E  D+++ L  L +  G      +    +R
Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234


>UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1PZU0_9BACT
          Length = 283

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A       +L  E +DL    ++H  +  + +  D+  V+    + + +R
Sbjct: 57  LVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVMKLCLDKMMRR 116

Query: 202 H 202
           H
Sbjct: 117 H 117


>UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM
          Length = 264

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 27/72 (37%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV 194
                  IA+   EE  E   +   +D   L  E  DL+YH+L    +  +        V
Sbjct: 28  LQQNFASIAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDV 87

Query: 195 IENLR----KRH 202
           I+ L     +RH
Sbjct: 88  IQQLAAKLIRRH 99


>UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9
          Length = 302

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
           +  + +  KV EE  E   A       E+  E  DL++ +  L +   +D    I     
Sbjct: 200 ADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIRSTNA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264


>UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frankia sp. CcI3
           RepID=Q2J4X9_FRASC
          Length = 116

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 24/93 (25%), Positives = 34/93 (36%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
                      +L   LAE+       S T      G   + +K+ EE  E  +AA    
Sbjct: 24  SSNVSNLKTFDELFVELAEKWRRRTPGSGTVAALDQGVHHLGKKLVEEAAEAWMAAEHEG 83

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           R     E S L+Y   +L+   GL L  V  +L
Sbjct: 84  RGRAAEEISQLLYWSQLLMISLGLSLDDVYSHL 116


>UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=Actinomycetales
           RepID=A4F800_SACEN
          Length = 334

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 13/66 (19%), Positives = 21/66 (31%), Gaps = 8/66 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDL---T 192
                 + + + EE  E   A    DR  L  E  D    +++H  +   +   D     
Sbjct: 125 EQDHDTLRKYLVEETYELLDAIEQRDRDALREELGDVLLQVLFHARIA-AEHDADPFGVD 183

Query: 193 TVIENL 198
            V   L
Sbjct: 184 EVAAEL 189


>UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF
          Length = 289

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E A A    D  ++  E  D++    +H  +  + Q  DL  VI      L +RH
Sbjct: 59  EEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRH 117


>UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LC99_MAGSM
          Length = 277

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 16/55 (29%), Positives = 25/55 (45%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            T  I  K+ EE  E A A   +DR     E  DL++ L+ L +   ++  T + 
Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233


>UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640_PELTS
          Length = 582

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D ++   E  DL+    +H  +  +++  D+  VI
Sbjct: 345 EQDHRTLKPYLLEEAYEVIEALDEEDMYKTCEELGDLLLQIVFHAQIAAENRHFDINDVI 404

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 405 AGISEKMIRRH 415


>UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX RepID=Q47SV3_THEFY
          Length = 246

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 17/70 (24%), Positives = 28/70 (40%), Gaps = 10/70 (14%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQD--QGLDLTTV-- 194
            + +A+ + EE  ET       D   L  E  D++    +H  V  +    G  +  V  
Sbjct: 35  HESLAKYLIEEAYETVETIERGDYDTLAEELGDVLLQVVFHARVAAERGPDGFTIDDVAD 94

Query: 195 --IENLRKRH 202
             I+ L +RH
Sbjct: 95  AIIDKLVRRH 104


>UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGC7_KOSOT
          Length = 256

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    +  E   E  DL+    +H  +  +     +  V+    + L +R
Sbjct: 38  LIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVVETLSDKLIRR 97

Query: 202 H 202
           H
Sbjct: 98  H 98


>UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces
           RepID=D1X3V9_9ACTO
          Length = 335

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 20/79 (25%), Positives = 31/79 (39%), Gaps = 13/79 (16%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG- 188
           +T++    G   +A+   EE  E   A    DR EL  E  D++    +H  +  +D   
Sbjct: 147 WTSRKTHRG---LAKYAIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEDPDE 203

Query: 189 -LDLTTVI----ENLRKRH 202
              +  V     E L  RH
Sbjct: 204 PFAVDDVAGGLVEKLIHRH 222


>UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepID=C8XKR8_NAKMY
          Length = 240

 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 15/69 (21%), Positives = 26/69 (37%), Gaps = 12/69 (17%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQ----DQGLDLTTVI-- 195
           + + + EE  E   A    DR  +  E  D    +++H  +  +      G D+  V   
Sbjct: 40  LVRYLLEECYELVEAVESGDRAAIREELGDVLLQVLFHARIAAETPRDQGGFDIDDVAGD 99

Query: 196 --ENLRKRH 202
               L +RH
Sbjct: 100 LVAKLVRRH 108


>UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=C9N950_9ACTO
          Length = 328

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTT 193
               + +A+   EE  E   A    DR EL  E  D++    +H  +  +DQ     +  
Sbjct: 140 QKTHQGLAKYAIEEAYELVEAIEDGDREELREELGDVLLQVVFHARIAQEDQEEPFGIDD 199

Query: 194 VIE----NLRKRH 202
           V       L  RH
Sbjct: 200 VAATIVEKLIHRH 212


>UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL
          Length = 180

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 12/51 (23%), Positives = 21/51 (41%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
           + EE  E +  A       L  E +D++Y         G+DL  V+  + +
Sbjct: 85  LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135


>UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC0_DESHD
          Length = 493

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 14/68 (20%), Positives = 24/68 (35%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI--- 195
              +   + EE  E   A    D + L  E  DL+    +H  V  +        V+   
Sbjct: 252 HDSLKPYLIEESYEVLEAIEAQDMYNLAEELGDLLLQVVFHAQVAQEAGEFQFQDVLKGI 311

Query: 196 -ENLRKRH 202
            + + +RH
Sbjct: 312 IDKMIRRH 319


>UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RA19_AMMDK
          Length = 495

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 12/62 (19%), Positives = 25/62 (40%), Gaps = 6/62 (9%)

Query: 146 IAQKVGEEGVETALAA--TVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR 199
           + + + EE  E   A      D   L  E  DL+    +H  +  +    +L  V+ ++ 
Sbjct: 262 LKKYLLEETYEVLEAIDRVEEDPHNLCEELGDLLLQIVFHCQIAAEAGRFNLDDVVRSIT 321

Query: 200 KR 201
           ++
Sbjct: 322 RK 323


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.315    0.154    0.494 

Lambda     K      H
   0.267   0.0475    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,478,809,273
Number of Sequences: 3077464
Number of extensions: 69290161
Number of successful extensions: 173018
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 717
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 171668
Number of HSP's gapped (non-prelim): 978
length of query: 203
length of database: 1,040,396,356
effective HSP length: 122
effective length of query: 81
effective length of database: 664,945,748
effective search space: 53860605588
effective search space used: 53860605588
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.3 bits)
S2: 90 (39.1 bits)
