BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (203 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero...   267   1e-70
UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri...   266   3e-70
UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ...   265   7e-70
UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac...   263   2e-69
UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob...   261   8e-69
UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon...   260   2e-68
UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell...   258   7e-68
UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI...   258   1e-67
UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri...   257   1e-67
UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   255   8e-67
UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm...   253   2e-66
UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   251   8e-66
UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   251   9e-66
UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific...   248   8e-65
UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi...   247   1e-64
UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell...   247   2e-64
UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   245   5e-64
UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact...   245   5e-64
UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba...   245   5e-64
UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac...   245   8e-64
UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   245   8e-64
UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   245   1e-63
UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana...   243   3e-63
UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   241   9e-63
UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul...   239   4e-62
UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm...   238   7e-62
UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p...   238   9e-62
UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ...   236   3e-61
UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   235   6e-61
UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy...   234   1e-60
UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote...   234   1e-60
UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   233   2e-60
UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman...   233   2e-60
UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy...   232   5e-60
UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   232   8e-60
UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI...   231   1e-59
UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos...   230   1e-59
UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   230   2e-59
UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   230   2e-59
UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5     230   2e-59
UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His...   230   3e-59
UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI...   228   6e-59
UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep...   228   7e-59
UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His...   228   9e-59
UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte...   228   1e-58
UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   226   3e-58
UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos...   225   7e-58
UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   225   8e-58
UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero...   225   9e-58
UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ...   225   1e-57
UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   222   9e-57
UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   216   3e-55
UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   215   8e-55
UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper...   208   1e-52
UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A...   207   1e-52
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   199   5e-50
UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI...   198   1e-49
UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel...   197   2e-49
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   189   4e-47
UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T...   188   8e-47
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   188   1e-46
UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros...   187   1e-46
UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz...   185   6e-46
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   182   6e-45
UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor...   175   6e-43
UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu...   174   2e-42
UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu...   174   2e-42
UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon...   171   1e-41
UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   168   9e-41
UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   168   1e-40
UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter...   167   2e-40
UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte...   167   2e-40
UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   167   2e-40
UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo...   166   3e-40
UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   166   4e-40
UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   166   4e-40
UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell...   164   2e-39
UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin...   164   2e-39
UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar...   163   3e-39
UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   163   3e-39
UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte...   163   4e-39
UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap...   163   4e-39
UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap...   162   7e-39
UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m...   162   7e-39
UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin...   162   8e-39
UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo...   161   1e-38
UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote...   161   1e-38
UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   161   2e-38
UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote...   161   2e-38
UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte...   160   2e-38
UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul...   160   2e-38
UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   160   3e-38
UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   160   3e-38
UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote...   160   4e-38
UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch...   159   5e-38
UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein...   159   5e-38
UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm...   159   5e-38
UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   159   5e-38
UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein...   159   7e-38
UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax...   158   7e-38
UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   158   9e-38
UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote...   157   2e-37
UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   156   3e-37
UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin...   156   3e-37
UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob...   156   3e-37
UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact...   156   4e-37
UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob...   156   4e-37
UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob...   156   4e-37
UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte...   155   6e-37
UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon...   155   8e-37
UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero...   155   1e-36
UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan...   154   1e-36
UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu...   154   2e-36
UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte...   153   5e-36
UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax...   153   5e-36
UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   152   5e-36
UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote...   152   6e-36
UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p...   152   6e-36
UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ...   152   7e-36
UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=...   150   4e-35
UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob...   150   4e-35
UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   150   4e-35
UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo...   149   5e-35
UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu...   149   5e-35
UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro...   149   6e-35
UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin...   148   8e-35
UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo...   148   9e-35
UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr...   148   9e-35
UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   147   2e-34
UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero...   147   2e-34
UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom...   146   5e-34
UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   145   1e-33
UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl...   144   1e-33
UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo...   141   2e-32
UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax...   139   6e-32
UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha...   135   7e-31
UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico...   134   2e-30
UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros...   131   1e-29
UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing...   130   2e-29
UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr...   129   6e-29
UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos...   127   2e-28
UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo...   124   1e-27
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   123   3e-27
UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos...   119   7e-26
UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid...   117   2e-25
UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   116   4e-25
UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu...   116   6e-25
UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact...   115   1e-24
UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=...   113   5e-24
UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact...   111   1e-23
UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost...   111   1e-23
UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm...   111   1e-23
UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C...   111   1e-23
UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph...   110   2e-23
UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh...   110   3e-23
UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo...   109   4e-23
UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap...   109   6e-23
UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta...   108   1e-22
UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto...   108   1e-22
UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph...   108   1e-22
UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi...   108   2e-22
UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell...   108   2e-22
UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk...   108   2e-22
UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri...   107   2e-22
UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins...   106   6e-22
UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto...   106   6e-22
UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul...   106   6e-22
UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote...   106   7e-22
UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot...   105   8e-22
UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot...   105   9e-22
UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha...   105   1e-21
UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra...   105   1e-21
UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl...   104   1e-21
UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...   104   2e-21
UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom...   104   2e-21
UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther...   104   2e-21
UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot...   104   3e-21
UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi...   103   4e-21
UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   103   5e-21
UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   102   8e-21
UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   102   8e-21
UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph...   101   1e-20
UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br...   100   5e-20
UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    99   7e-20
UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha...    99   1e-19
UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu...    99   1e-19
UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph...    98   1e-19
UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo...    98   1e-19
UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    97   3e-19
UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu...    97   3e-19
UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob...    97   3e-19
UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    96   5e-19
UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury...    95   1e-18
UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov...    93   4e-18
UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin...    93   6e-18
UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom...    92   1e-17
UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re...    91   2e-17
UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo...    90   7e-17
UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre...    89   1e-16
UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti...    88   1e-16
UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost...    87   4e-16
UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact...    85   1e-15
UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba...    84   3e-15
UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p...    84   3e-15
UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta...    82   9e-15
UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob...    82   1e-14
UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc...    82   1e-14
UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    82   1e-14
UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo...    81   1e-14
UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha...    81   3e-14
UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus...    80   4e-14
UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac...    79   1e-13
UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    78   2e-13
UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo...    77   3e-13
UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth...    76   5e-13
UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax...    71   2e-11
UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph...    64   4e-09
UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase...    59   9e-08
UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas...    59   1e-07
UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax...    59   1e-07
UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID...    54   3e-06
UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp....    53   4e-06
UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip...    51   2e-05
UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax...    51   2e-05
UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm...    51   2e-05
UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog...    48   2e-04
UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma...    48   3e-04
UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact...    47   4e-04
UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil...    47   4e-04
UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm...    46   7e-04
UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1...    46   7e-04
UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip...    46   9e-04
UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ...    46   9e-04
UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID...    46   0.001
UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus...    46   0.001
UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R...    45   0.001
UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ...    45   0.001
UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frank...    45   0.001
UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=A...    45   0.002
UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=...    45   0.002
UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC...    45   0.002
UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640...    45   0.002
UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX Re...    44   0.002
UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB...    44   0.004
UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str...    44   0.004
UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepI...    43   0.005
UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Str...    43   0.006
UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY...    43   0.006
UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC...    43   0.007
UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii K...    43   0.007
UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus...    43   0.007
UniRef50_B3DW98 Predicted pyrophosphatase n=1 Tax=Methylacidiphi...    43   0.008
UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber D...    43   0.010
UniRef50_C0QR38 MazG family protein n=4 Tax=Hydrogenothermaceae ...    42   0.010
UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermo...    42   0.010
UniRef50_C7MMP1 MazG family protein n=2 Tax=Coriobacteriaceae Re...    42   0.011
UniRef50_B8HTG9 MazG family protein n=2 Tax=Chroococcales RepID=...    42   0.013
UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax...    42   0.015
UniRef50_A8ZVD0 MazG family protein n=1 Tax=Desulfococcus oleovo...    42   0.015
UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus k...    42   0.016
UniRef50_Q0S4J7 Putative uncharacterized protein n=4 Tax=Nocardi...    41   0.018
UniRef50_D2RFM2 MazG nucleotide pyrophosphohydrolase n=3 Tax=Eur...    41   0.018
UniRef50_A9FF91 Putative uncharacterized protein mazG n=1 Tax=So...    41   0.019
UniRef50_C9XSA1 Putative bifunctional protein [include tetrapyrr...    41   0.020
UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Glucona...    41   0.022
UniRef50_B0CCR5 MazG family protein n=8 Tax=Cyanobacteria RepID=...    41   0.023
UniRef50_B2TI15 MazG family protein n=5 Tax=Clostridium RepID=B2...    41   0.023
UniRef50_B7JWE8 MazG nucleotide pyrophosphohydrolase n=2 Tax=Cya...    41   0.025
UniRef50_A2CDV8 MazG family protein n=11 Tax=Cyanobacteria RepID...    41   0.025
UniRef50_B5JET8 MazG family protein n=1 Tax=Verrucomicrobiae bac...    41   0.025
UniRef50_A6LPK0 MazG family protein n=10 Tax=Clostridia RepID=A6...    41   0.026
UniRef50_Q04VW6 Pyrophosphatase n=6 Tax=Leptospira RepID=Q04VW6_...    41   0.027
UniRef50_D2LXK4 MazG family protein n=2 Tax=Bacillus RepID=D2LXK...    41   0.029
UniRef50_A8L147 MazG family protein n=4 Tax=Frankia RepID=A8L147...    41   0.029
UniRef50_C8WFT9 MazG family protein n=3 Tax=Zymomonas mobilis Re...    41   0.031
UniRef50_B0K4Q4 MazG family protein n=10 Tax=Clostridia RepID=B0...    41   0.032
UniRef50_D0LI16 MazG family protein n=1 Tax=Haliangium ochraceum...    41   0.033
UniRef50_B5HJI9 Nucleoside triphosphate pyrophosphohydrolase n=2...    41   0.033
UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG fami...    41   0.034
UniRef50_Q0B0R5 MazG protein n=1 Tax=Syntrophomonas wolfei subsp...    41   0.035
UniRef50_Q2LVG8 MazG-like domain protein n=1 Tax=Syntrophus acid...    41   0.036
UniRef50_Q1K0K7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Des...    40   0.038
UniRef50_D1W9A9 MazG family protein n=5 Tax=Prevotella RepID=D1W...    40   0.039
UniRef50_B0VJQ1 Nucleoside triphosphate pyrophosphohydrolase n=1...    40   0.043
UniRef50_B1J1L8 MazG family protein n=14 Tax=Bacteria RepID=B1J1...    40   0.044
UniRef50_Q6AK03 Putative uncharacterized protein n=1 Tax=Desulfo...    40   0.045
UniRef50_Q7V9I6 Predicted pyrophosphatase n=1 Tax=Prochlorococcu...    40   0.048
UniRef50_Q3Z619 MazG family protein n=5 Tax=Dehalococcoides RepI...    40   0.048
UniRef50_Q2JT55 MazG family protein n=4 Tax=Bacteria RepID=Q2JT5...    40   0.048
UniRef50_C7RAH4 MazG family protein n=1 Tax=Kangiella koreensis ...    40   0.057
UniRef50_Q3AVT5 MazG n=4 Tax=Cyanobacteria RepID=Q3AVT5_SYNS9          40   0.059
UniRef50_Q7D8Z6 Transcriptional regulator, MazG family n=3 Tax=M...    40   0.059
UniRef50_B5YFB4 MazG n=2 Tax=Dictyoglomus RepID=B5YFB4_DICT6           40   0.059
UniRef50_B9CMC9 Tetrapyrrole methylase family protein, MazG fami...    40   0.059
UniRef50_B1XI42 MazG family protein n=22 Tax=Cyanobacteria RepID...    40   0.060
UniRef50_Q3JCR4 Tetrapyrrole methylase family protein / MazG fam...    39   0.063
UniRef50_Q6MDA8 Putative uncharacterized protein n=1 Tax=Candida...    39   0.064
UniRef50_Q6G3M6 MazG protein n=1 Tax=Bartonella henselae RepID=Q...    39   0.068
UniRef50_Q0A8N1 MazG family protein n=4 Tax=Proteobacteria RepID...    39   0.071
UniRef50_C0QWZ2 Nucleoside triphosphate pyrophosphohydrolase n=2...    39   0.071
UniRef50_A2BTR6 MazG family protein n=7 Tax=Prochlorococcus mari...    39   0.081
UniRef50_A8ATT3 Gp45 n=1 Tax=Listeria phage P35 RepID=A8ATT3_9CAUD     39   0.083
UniRef50_B2UPD1 MazG family protein n=1 Tax=Akkermansia muciniph...    39   0.084
UniRef50_Q30YJ6 MazG family protein n=6 Tax=Desulfovibrionales R...    39   0.086
UniRef50_C0Q9D5 Tetrapyrrole methylase family protein (MazG fami...    39   0.087
UniRef50_C0WDQ0 Putative uncharacterized protein n=1 Tax=Acidami...    39   0.093
UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferro...    39   0.095
UniRef50_C1TQS2 MazG family protein n=3 Tax=Synergistaceae RepID...    39   0.096

>UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C4Y5_SPHTD
          Length = 228

 Score =  267 bits (684), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 86/205 (41%), Positives = 121/205 (59%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGE
Sbjct: 14  VDAVRFD-ERGLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGE 72

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQ 117
           TSGN   VV I PDCD D LLV   P GPTCH GT +CF                  + +
Sbjct: 73  TSGNVHEVVEIRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDE 132

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           + +++AER++   E SYT  L  +G  +I +K+GEE  E  +AA   D   L NEA+DL+
Sbjct: 133 VARVVAERRAHPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLI 192

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLL+   +    V   LR R 
Sbjct: 193 YHLLVLLEASDVPTERVWAVLRTRR 217


>UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria
           RepID=C6PCK8_CLOTS
          Length = 228

 Score =  266 bits (681), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 80/204 (39%), Positives = 118/204 (57%), Gaps = 9/204 (4%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L ++   GL+P IVQ   + EVLM+ YMN E+L+K+LE+ +  FFSR++Q LW KG
Sbjct: 8   NIDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKG 66

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD--------TAHQWLFLYQ 117
           ETSGN  ++ +I  DCD DTLLV   P GP CH G +SCF             +   L  
Sbjct: 67  ETSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSN 126

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + +  RK      SYT  L+  G  +I +K+GEE  E  +A+    + E+  E +D +
Sbjct: 127 LYRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYI 186

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YHL+VL+ ++G++L  V + + KR
Sbjct: 187 YHLMVLMVEKGINLNDVYKEISKR 210


>UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT
          Length = 215

 Score =  265 bits (677), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 98/196 (50%), Positives = 135/196 (68%), Gaps = 2/196 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   +  VLMLGYMN EA  KT+E+ KVTF+SR++  LWTKGETS
Sbjct: 2   QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126
           GN+L++VSI  DCDNDTLLV  +P GPTCH GT +C+G+T   +  LFL +L+  +  R 
Sbjct: 62  GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P+ SYT  L+  G ++IAQKVGEE VET + A   +   L  EASD++YHL+VLL  
Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181

Query: 187 QGLDLTTVIENLRKRH 202
           +GL +  +   L +RH
Sbjct: 182 KGLHIEDLARELARRH 197


>UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria
           RepID=HIS2_VIBVY
          Length = 211

 Score =  263 bits (673), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 129/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
                   ++WEK DGL+P IVQ   S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL
Sbjct: 7   EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---GDTAHQWLFLYQL 118
           WTKGETSGN L +V+++ DCDNDTLLV  NPIGPTCH GT++C+        Q ++L+QL
Sbjct: 67  WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT  D+ EL  E++DL+Y
Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLLVLLQDQGL +  VI  L++RH+
Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211


>UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria
           RepID=B5EQF3_ACIF5
          Length = 230

 Score =  261 bits (668), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 80/209 (38%), Positives = 111/209 (53%), Gaps = 12/209 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W   DGL+P I Q A SG VLML +MN +AL  TL  G  T++SR++Q LW K
Sbjct: 10  AILAAVRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ---- 120
           GETSG+  ++V +  DCD DTLL+     GP CH G  +CF                   
Sbjct: 69  GETSGHIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGS 128

Query: 121 -------LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
                   L  R++ADP  SY A+L   G  RI +KVGEE  E  +A   H+   +  EA
Sbjct: 129 ILDSLQVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEA 188

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL+V L+++ L +  V+  L +R 
Sbjct: 189 ADLVFHLMVALEERDLHIDDVLGELARRE 217


>UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae
           RepID=C4V2J2_9FIRM
          Length = 235

 Score =  260 bits (665), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 79/220 (35%), Positives = 116/220 (52%), Gaps = 22/220 (10%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  +    + D     GL+P IVQ   + +VLML YMN E+L+KT+E+G   ++SR++Q+
Sbjct: 2   MNVDMSMIQFD---DRGLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQK 57

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105
           LW KGETSGN   +  I+ DCD DT+L+     G  CH GT SCF               
Sbjct: 58  LWKKGETSGNVQRIKEISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIP 117

Query: 106 ---GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
               +       L  L Q++  R+    E SYT  L+  G  +I +K+GEE  ET +A+ 
Sbjct: 118 LIEKEEHPLTEVLASLYQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASK 177

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + R ++  E  DL YH LVLL    +    ++E L++R+
Sbjct: 178 NNIREDVLYEMGDLWYHCLVLLAYHNMTPEDLLEELKRRN 217


>UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms
           RepID=HIS2_SYNPX
          Length = 222

 Score =  258 bits (660), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 72/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L+     +L +    GL+P I Q  + G VLM+ +MN E++ +TL SG+  ++SR++Q L
Sbjct: 4   LSPAFIDQLRF-NEAGLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLF------ 114
           W KG TSG+   + SI  DCD D LL+     G   CH G  SCF +   Q         
Sbjct: 63  WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122

Query: 115 ------LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                   +L +++  R+    E SYT KL   G  +I +K+GEE  E  +A    +  E
Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  EA+D+++H+ V L   G+    V E L  R 
Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216


>UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria
           RepID=Q2JWX9_SYNJA
          Length = 231

 Score =  258 bits (659), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 78/198 (39%), Positives = 107/198 (54%), Gaps = 9/198 (4%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P IVQ  + G VLM+ +MN E+L KTLE+G+  F+SR++Q LW KGETSG+   
Sbjct: 31  NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGETSGHVQW 90

Query: 74  VVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFG--------DTAHQWLFLYQLEQLLAE 124
           V  I  DCD+D L++L   +G   CH G  SCF         D       L Q+  ++  
Sbjct: 91  VKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQVFAVVKA 150

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R++     SYT+ L A G   I +K+GEE  E  +AA   D+  L  E +DL YH LV L
Sbjct: 151 RQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLWYHCLVAL 210

Query: 185 QDQGLDLTTVIENLRKRH 202
               +D+  V   L+ R 
Sbjct: 211 AHHQVDIRDVYRQLQARR 228


>UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria
           RepID=C6J1M1_9BACL
          Length = 231

 Score =  257 bits (658), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 92/213 (43%), Positives = 128/213 (60%), Gaps = 13/213 (6%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            E   + + W+   GL+P IVQ A S EVLML YMN E+L K++E+G+  F+SR++  LW
Sbjct: 15  IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------AH 110
            KG TSGN   + ++  DCD DTLLV     GP CH G  +CF  T              
Sbjct: 74  NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           ++  L +LEQL+AER +  PE +YT  L+  G  +I +KVGEE  E+ +AA   D  EL 
Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E SDL+YHLLVLL+++ L L  +++ L +RH+
Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226


>UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=A9B1U1_HERA2
          Length = 212

 Score =  255 bits (651), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 104/203 (51%), Positives = 130/203 (64%), Gaps = 10/203 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           EL ++ + GL+P +VQHA SGEVLM+GYMN EAL KT  SG VTF+SR++Q+LWTKGETS
Sbjct: 3   ELTYD-SQGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL---------FLYQLE 119
           GN L  ++   DCDND LL+LA P GPTCH G+ SCF  T              F+ QL 
Sbjct: 62  GNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQLF 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + L ER+   P  SYT  L   G  +I +K+GEE  E  +AA   +  EL NEASDL+YH
Sbjct: 122 EFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLIYH 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           L VLL +QG+    V   LR+RH
Sbjct: 182 LFVLLLNQGVSPEDVWFTLRERH 204


>UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes
           RepID=HIS2_OCEIH
          Length = 215

 Score =  253 bits (647), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 84/207 (40%), Positives = 120/207 (57%), Gaps = 6/207 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M        L ++   GL+P IVQ   SG+VL L YMN +++ KT+E+ +  F+SR +Q 
Sbjct: 1   MTKSISIEHLQFD-EKGLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQE 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----L 115
           LW KG TSGN   V  I+ DCD D +LVL +  GP CH G  SCF +  ++        +
Sbjct: 60  LWNKGATSGNKQTVKQISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQII 119

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            Q+   + ER     E +YT+ L+  G  +I +K+GEE  E  +AA   D+ ELT+E SD
Sbjct: 120 PQVSAKIKERHEHPVEGAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSD 179

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202
           L+YH LVL++ QG+ L  + + L KRH
Sbjct: 180 LLYHSLVLMEQQGVTLEDIKKELYKRH 206


>UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Legionella
           RepID=C6N0X1_9GAMM
          Length = 207

 Score =  251 bits (642), Expect = 8e-66,   Method: Composition-based stats.
 Identities = 95/198 (47%), Positives = 131/198 (66%), Gaps = 1/198 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW+K +GL+P I+Q+A +G VLMLGYMN EAL  T+ +G++T +SR+++RLW KGE
Sbjct: 6   ISALDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGE 65

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQLLAER 125
           TSGN + V  I+ DCD+D+LL++  P GP CH G +SC+    H    F+  L +++ ER
Sbjct: 66  TSGNTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINER 125

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
                E SYTA+L ASG  R AQKVGEE VET +AA      E  NE +DL++HLLVLL+
Sbjct: 126 AETQAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLK 185

Query: 186 DQGLDLTTVIENLRKRHQ 203
              L    V++ L+ R +
Sbjct: 186 ASELSFYDVLQCLQDRDR 203


>UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=10 Tax=Bacteria
           RepID=C0QVS5_BRAHW
          Length = 220

 Score =  251 bits (642), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 115/205 (56%), Gaps = 6/205 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + + +  +L ++   GL+P IV    + EVL L YMN E+L+ +++  K  F+SR++Q L
Sbjct: 4   INQNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL-----Y 116
           W KGETSGN+ ++ SI  DCDND L++     GP CH G+ SCF +  +           
Sbjct: 63  WRKGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSID 122

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +L+  RK    E SYT  L+ SG  +I +KVGEE  E  + A      E   E SDL
Sbjct: 123 KLYKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDL 182

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           +YH LVL+ ++G+ +  +   L  R
Sbjct: 183 LYHSLVLMVEKGITINDIKNELASR 207


>UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae
           RepID=B4U8T9_HYDS0
          Length = 207

 Score =  248 bits (634), Expect = 8e-65,   Method: Composition-based stats.
 Identities = 80/205 (39%), Positives = 117/205 (57%), Gaps = 9/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+PVI Q A SGE+ ML Y N EA+ KT+E+G   +FSR++  +W KGE
Sbjct: 3   IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG-------DTAHQWLFLYQL 118
           TSG    V+ I  DCDNDTL+ +        CH G  +CF         +   +  L  L
Sbjct: 62  TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E+L+ +R S   E+SYT+KL   G  RI QKVGEE +E+ +A    D+ E+  E +DL+Y
Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           H+LV ++   +    V   L +RH+
Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206


>UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3
           Tax=Clostridiales RepID=C4Z9Z2_EUBR3
          Length = 427

 Score =  247 bits (632), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%)

Query: 1   MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           +L +    +L W      +DG++PVIVQ   + +VLML YMN EA + T+ SG++T++SR
Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108
           ++  LWTKG TSG+   V S+  DCD DT+L   + +G  CH    +CF +         
Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            +    L  +  ++ +R     E SYT  +   G   I +K+G E  E  LAA   D  +
Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           L  E SD MYH ++L+  + +    +   L +R
Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427


>UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms
           RepID=HIS2_THEP3
          Length = 216

 Score =  247 bits (631), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 79/215 (36%), Positives = 114/215 (53%), Gaps = 22/215 (10%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E   +EL ++   GL+PVI Q   + EVLM+ Y+    L K+LE+GKV +FSR++ +LW 
Sbjct: 2   ENILKELKFDDR-GLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-------------- 109
           KGETSG+F  + SI+ DCD DTLL+    +   CH G  SCF                  
Sbjct: 61  KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120

Query: 110 -------HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
                       L ++  ++ +R     E SYT  L+  G  +I +KVGEE  E  + A 
Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             D+ E+  E SDL+YHLLVL+ ++G+ L  + E 
Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215


>UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI
          Length = 244

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 85/218 (38%), Positives = 115/218 (52%), Gaps = 27/218 (12%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + W+   GL+P I Q ++S EVLML YMN EAL+ TL++G   +FSR+KQR+W KGE SG
Sbjct: 6   IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------------- 106
           N   V  I  DCD+D++L+  N  G  CH G  SCF                        
Sbjct: 65  NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124

Query: 107 ---DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
               + + +  L  L   L ERK+AD  TSYTA L+A GT  IA+K+ EE  E   A   
Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            D  E+  E +D+ YH+LV L  + +    + + L KR
Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222


>UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria
           RepID=HIS2_XANCP
          Length = 206

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 115/197 (58%), Positives = 135/197 (68%), Gaps = 2/197 (1%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW K DGL+PVIVQ A +  VLMLGYMN EAL  T   G+VTFFSR+KQRLWTKGE
Sbjct: 12  LDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTKGE 71

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGN L VV+I  DCD DTLLV A P GPTCH G +SCF        FL  L+ L+AER+
Sbjct: 72  SSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTA--PSQFLGSLDALIAERE 129

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P  SYT KL+  G +RIAQKVGEEGVETALA  V    EL  E++DL+YHL+VLL+ 
Sbjct: 130 HERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLLRA 189

Query: 187 QGLDLTTVIENLRKRHQ 203
           +GL L   +  L  RH+
Sbjct: 190 RGLGLGDAVALLESRHK 206


>UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae
           RepID=C5SM65_9CAUL
          Length = 215

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 110/202 (54%), Positives = 136/202 (67%), Gaps = 1/202 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LT      LD+ K DGL+P IVQ A + +VLMLGYM+  AL +TL   +VTFFSR+K   
Sbjct: 11  LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLEQ 120
           W KGETSG+FLN+VS+  DCD D LLVLA P+GPTCH  T+SCF  DTA    F+  L  
Sbjct: 71  WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ +R  A P  SYTA+L   G  +IAQKVGEEG+ETALA    D  EL NEA+DL+YHL
Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
            VLL  +   L  V++ LR+RH
Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212


>UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria
           RepID=HIS2_BLOFL
          Length = 213

 Score =  245 bits (625), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT ++ + L+W K  GL+P I+QH++SGEVLMLGYMN E++  T ++G VTFFSR+K R
Sbjct: 1   MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGE+SGN L +++  PDCD D+LL+L  P G TCHK T+SCF      + FL+QLE 
Sbjct: 61  LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120

Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +K+      + ++SYT+ LY SG +RIAQKVGEEG+ETALAA   +   L +EASD
Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+YHLLVLLQ + L+   VI+ LR R +
Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208


>UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius LAA1 RepID=B7DRK3_9BACL
          Length = 254

 Score =  245 bits (625), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 77/250 (30%), Positives = 115/250 (46%), Gaps = 49/250 (19%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           +  + +   + ++   GL+PV+ Q A +GEVLM+ Y + EAL +TL +G   ++SR+++ 
Sbjct: 4   VKGDVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRRE 63

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G  +CF               
Sbjct: 64  YWRKGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAAD 123

Query: 109 --------------------------------AHQWLFLYQLEQLLAERKSADPETSYTA 136
                                                 L +L  ++  R    P+ SYT 
Sbjct: 124 EGGAKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTT 183

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDL 191
            L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+  
Sbjct: 184 YLFTHGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHP 243

Query: 192 TTVIENLRKR 201
             V   L KR
Sbjct: 244 VDVWRTLEKR 253


>UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=1 Tax=Candidatus Poribacteria
           sp. WGA-A3 RepID=D2MIV8_9BACT
          Length = 234

 Score =  245 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 113/205 (55%), Gaps = 14/205 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + ++   GL+P +VQ    G +LML YMN EALD+TL++G V F+SR++++LW KGETSG
Sbjct: 16  IQFD-ERGLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSG 74

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-------------LY 116
           ++L    +  DCD D LLV A P GPTCH    +CF                        
Sbjct: 75  HYLLCKRVFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFD 134

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +++ +RK+   E SY + L   G  RI +KV EE  E  LA     R E+ +E +DL
Sbjct: 135 RLYEMVLQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADL 194

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           ++H +V L    + +T + + L KR
Sbjct: 195 IFHSIVALGHCEIPMTAIQQELGKR 219


>UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius
           thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ
          Length = 211

 Score =  243 bits (620), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 87/202 (43%), Positives = 118/202 (58%), Gaps = 14/202 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L V
Sbjct: 7   QDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLIV 66

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ--------------LEQ 120
            S+  DCD DTLL L  P GP CH G +SCF +   +                    L Q
Sbjct: 67  TSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLNQ 126

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           L+ +R    P+ SY  KL   G  ++ +KVGEE  E   A    D+ E+ +E++DL++H 
Sbjct: 127 LIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFHT 186

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
           L+ L+   +DL+ V++ L  RH
Sbjct: 187 LLALKYFQVDLSEVLQELHNRH 208


>UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WUY1_ALIAD
          Length = 256

 Score =  241 bits (616), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 79/255 (30%), Positives = 116/255 (45%), Gaps = 54/255 (21%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +   + ++   GL+PV+ Q A +G+VLML Y + EAL +TL +G   ++SR+++ 
Sbjct: 1   MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G   CF               
Sbjct: 61  YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120

Query: 109 -------------------------------------AHQWLFLYQLEQLLAERKSADPE 131
                                                A     L +L  ++  R    P+
Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186
            SYT  L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL + 
Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240

Query: 187 QGLDLTTVIENLRKR 201
            G+    V + L KR
Sbjct: 241 VGVQPADVWQVLEKR 255


>UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms
           RepID=C9RV77_GEOSY
          Length = 216

 Score =  239 bits (611), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 97/204 (47%), Positives = 128/204 (62%), Gaps = 10/204 (4%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
            ++ ++   GL+P IVQ A S EVL L YMN E+L+KTLE+G+  F+SR++Q LW KG T
Sbjct: 3   ADIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGAT 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---------GDTAHQWLFLYQL 118
           SGN   VV I  DCD D LLVL  P GP CH G+ SCF            A ++  L +L
Sbjct: 62  SGNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNEL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQ++A+R +  PE SYT  L+  G  +I +KVGEE  E  +AA   +  EL  EA+DL+Y
Sbjct: 122 EQIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVLL++Q L L  V+  L +RH
Sbjct: 182 HLLVLLREQKLPLDAVLATLAERH 205


>UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga
           RepID=HIS2_THEMA
          Length = 197

 Score =  238 bits (608), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+VQ   +GEVLML Y N EAL+ T ++G   FFSR +Q++W KGETSGN + VV I
Sbjct: 4   LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63

Query: 78  APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQWL------FLYQLEQLLAERKSAD 129
             DCD+D  L + +       CH G  SCF    H++       F  +L +L+ +RK   
Sbjct: 64  RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT KL+  G  +IA+K GEE VE       +DR  L  E +D+MYHL VL+ D G+
Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183

Query: 190 DLTTVIENLRKRHQ 203
            +  V+  L KR +
Sbjct: 184 TVQDVMRELEKRRK 197


>UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1
           Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL
          Length = 207

 Score =  238 bits (608), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 99/197 (50%), Positives = 133/197 (67%), Gaps = 1/197 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             +D+EK +GL+PV+VQ A + +VL L YM+  ALD+T++SG+ TFFSR++   W KGET
Sbjct: 5   AAIDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGET 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLEQLLAERK 126
           SG+ L+VV I  DCD+D L++  NP+G  CH   +SCFG         + +LEQ +AER 
Sbjct: 65  SGDRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERA 124

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           +ADP  S+TAKL   G KRIAQKVGEEGVETALA       EL +EA+DL+YHLLVLL  
Sbjct: 125 AADPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHA 184

Query: 187 QGLDLTTVIENLRKRHQ 203
           + +    V++ L  R +
Sbjct: 185 RNMVFQDVLDVLASRAE 201


>UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KI1_SYMTH
          Length = 210

 Score =  236 bits (603), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%)

Query: 27  VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86
            +G+VLM  YMN EAL  TLE+G   ++SR++Q LW KG TSG+   V  I  DCD D+L
Sbjct: 2   RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61

Query: 87  LVLANPIGPTCHKGTSSCFGD-----------------------TAHQWLFLYQLEQLLA 123
           L+L    G  CH+GT SCF                                L +L  +LA
Sbjct: 62  LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ER++     SYT++L+  G     +K+GEE  E  LA    DR  L  E +DL +H LV 
Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181

Query: 184 LQDQGLDLTTVIENLRKRH 202
           L DQGL    V + L  R 
Sbjct: 182 LVDQGLSPADVADQLASRR 200


>UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC
          Length = 251

 Score =  235 bits (601), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 80/237 (33%), Positives = 119/237 (50%), Gaps = 40/237 (16%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           + + ++DW+K  GL+PV++Q   +GEVLM+ YMN EAL+ T  +G   +FSR+K R+W K
Sbjct: 3   ENKIKIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKK 61

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------------- 108
           GE+SGN   V S   DCDNDTLL+     G  CH G  SCF +                 
Sbjct: 62  GESSGNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKI 121

Query: 109 -AHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
              ++  L +L  +  +RK +ADP+ SY AKLY  G     +K+ EE  E A A     R
Sbjct: 122 SKPKYEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSR 181

Query: 167 F---------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                                 ++  E +DL++H++V L   G+    ++  L +R+
Sbjct: 182 AKNYRDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238


>UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae
           RepID=D0LRT4_HALO1
          Length = 241

 Score =  234 bits (598), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 83/204 (40%), Positives = 115/204 (56%), Gaps = 16/204 (7%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L 
Sbjct: 21  NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG---------------DTAHQWLFLYQL 118
           V  +  DCD D ++V+A P GPTCH GT SCF                 +      L +L
Sbjct: 81  VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140

Query: 119 EQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           E ++A R+  AD E SYT  L   G  +I  K+ EE  E A      +R E+ +E +DL+
Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           +H++V L  + + L  V   L +R
Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224


>UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria
           RepID=HIS2_HELHP
          Length = 231

 Score =  234 bits (598), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +   R++DWE+ + L+P IVQ   S ++LML Y + ++L+ +L++    +FSR+KQR+W 
Sbjct: 2   QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107
           KGE SG+  ++  +  DCDND+L+ +   +G  CH G  SCF                  
Sbjct: 61  KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120

Query: 108 ---TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                  +  L  L  ++ +R+  + E SYTA L A G   I +K+ EE  E   A    
Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D   +  E +DL YH+LV L  + +    V++ LR+R
Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217


>UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=4 Tax=Flavobacteriales
           RepID=A4CLC1_9FLAO
          Length = 206

 Score =  233 bits (596), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 88/203 (43%), Positives = 124/203 (61%), Gaps = 6/203 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            + +D+EKT GL+P I+Q + +  VLMLGYM+ EAL+ T  SGKVTF+SR+K+RLWTKGE
Sbjct: 1   MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGNFL  V +  DCD D LL+ A P GP CH G+ +C+ +            + +   +
Sbjct: 61  SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120

Query: 127 SADPET------SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
               +T      SY A L   GT ++AQKVGEE VET + A   D     NE++DL++H 
Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           L+LLQ +G  +  +   L +RH+
Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203


>UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B858_THEAS
          Length = 205

 Score =  233 bits (596), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 94/201 (46%), Positives = 119/201 (59%), Gaps = 6/201 (2%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             ++W   D L+PV+VQ A SG VLML Y N EALD TL+ G+  FFSR++ RLW KGET
Sbjct: 3   DRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGET 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQLL 122
           SGN + V+ +  DCD D++L L    GP CH G  SCF            LFL++L +++
Sbjct: 62  SGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIV 121

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +R S   + SYT  L+  G  RIAQKVGEEGVE ALA    DR     EA+DL+YHL V
Sbjct: 122 DQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTV 181

Query: 183 LLQDQGLDLTTVIENLRKRHQ 203
            L+     L    + L  RHQ
Sbjct: 182 ALRRVDATLLDAEQVLMARHQ 202


>UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP
           pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN
          Length = 215

 Score =  232 bits (592), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 83/205 (40%), Positives = 112/205 (54%), Gaps = 8/205 (3%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              E+ ++  +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++  LW KG
Sbjct: 2   NIEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKG 60

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ-------L 118
             SGN   V+ +  DCD D +L    P GP CH G  +CF                   +
Sbjct: 61  AISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKV 120

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + L  R    PE SY  K++ +G  RI +K+GEE  E  +AA    R EL  EASDL++
Sbjct: 121 YRTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLF 180

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLL  L + GL    +   L +R+Q
Sbjct: 181 HLLFTLTELGLSPQDLARVLWERNQ 205


>UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TLB5_9BACT
          Length = 188

 Score =  232 bits (591), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 87/187 (46%), Positives = 113/187 (60%), Gaps = 5/187 (2%)

Query: 22  IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81
           +VQ A SGEVLML Y N E++  TLE G++ F+SR+++ +W KG TSGN L + S+  DC
Sbjct: 2   VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61

Query: 82  DNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LYQLEQLLAERKSADPETSYTA 136
           D D +L   +P+GP CH G  SCF    H         L +L   L +R    PE SYTA
Sbjct: 62  DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +L A    R+AQK+GEEGVETALA    DR +   EA+DL+YHLLV L    L    +  
Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181

Query: 197 NLRKRHQ 203
            L+KRH+
Sbjct: 182 ELKKRHK 188


>UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3
           Tax=Chloroflexi RepID=B9KXC5_THERP
          Length = 218

 Score =  231 bits (590), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 82/205 (40%), Positives = 117/205 (57%), Gaps = 9/205 (4%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
               + +   DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KG
Sbjct: 9   LLGAIRFG-ADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKG 67

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE- 124
           ETSG+ L +V +  DCD D LL   +P GPTCH G  SCF            +   + + 
Sbjct: 68  ETSGHVLELVELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILDE 127

Query: 125 -------RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
                  R       SYT+ L  +G  RIA+K+GEE  E  +AA   +   +  EA+DL+
Sbjct: 128 LASIIAARAVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLL 187

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLLQ  G+    V   L+ R 
Sbjct: 188 YHLLVLLQASGVPAGEVWRVLQARR 212


>UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc
           (Cinara cedri) RepID=Q058A1_BUCCC
          Length = 205

 Score =  230 bits (588), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 93/204 (45%), Positives = 131/204 (64%), Gaps = 1/204 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           ML +Q  + L+W K +GL+P I QH +SGE+LM GYMN +A DK + +   T +SR K+R
Sbjct: 1   MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLE 119
           +W KGETS NFL V +I+ DCD D +LV  NP G TCH    SCF       + FLY+LE
Sbjct: 61  IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
             +  +K     +SY + L++SG  RIAQK+GEE VE  +A   ++   + NE SDL++H
Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           L +LLQ   ++L  +I+NL+KR +
Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204


>UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Picrophilus torridus
           RepID=Q6KZD6_PICTO
          Length = 204

 Score =  230 bits (588), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 73/199 (36%), Positives = 111/199 (55%), Gaps = 13/199 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DG++PV+VQ   +G+VL L YM+  AL+ T+++G   ++SR+ +R+  KGE SGN   V
Sbjct: 9   NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFLYQLEQLLAE 124
           + I  DC++++LL+     GP CH G +SCF              +    L +LE L+ +
Sbjct: 69  MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R       SYT  L  SG + I +KVGEE +ET LA+    R  +  E +DL+YHL+V L
Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILAS---GRDRIVYETADLLYHLIVFL 185

Query: 185 QDQGLDLTTVIENLRKRHQ 203
               + L  V+  L +R +
Sbjct: 186 AFNNVSLFDVMNELNRRSK 204


>UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_PYRFU
          Length = 209

 Score =  230 bits (587), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 90/213 (42%), Positives = 124/213 (58%), Gaps = 14/213 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  E+   +++WEK +G++PVIVQ    GEVL L YMN EAL KTLE+G   ++SR+K R
Sbjct: 1   MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AH 110
           +  KGE SGN   V  I  DCDND LL++ +P GP CH G  SCF              +
Sbjct: 60  IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE+++  RK    E SYT+KL+  G ++I +K GEE +E  +A     R  + 
Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E +DL+YHLLVLL    + L  V+  LR+R +
Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209


>UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5
          Length = 229

 Score =  230 bits (587), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 80/199 (40%), Positives = 107/199 (53%), Gaps = 15/199 (7%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQ  ++G+V ML YM  E+L +TLE+G+ TFFSR++  LW KG TSGN L V S+
Sbjct: 10  LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE---------------QLL 122
             DCD D LL+LA P GPTCH G++SCF                             + L
Sbjct: 70  HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
             RK++    SYT KL   G   I  K+ EE  E A A        + +EA+D++YHLLV
Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L  +G+ L  V+  L  R
Sbjct: 190 GLASRGVPLRAVLSALASR 208


>UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT
          Length = 233

 Score =  230 bits (586), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 91/209 (43%), Positives = 128/209 (61%), Gaps = 8/209 (3%)

Query: 2   LTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTK 58
           L+E++   +  E   G   L+P +VQH  +G+VLMLGYM  EA + T  +GKVTFFSR++
Sbjct: 7   LSEKEILSVAEENAFGKADLIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSR 66

Query: 59  QRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL 113
           +++W KGETSGN L+V+ I  DCD DT+LVLA P+GPTCH G+ SCF           + 
Sbjct: 67  KKIWVKGETSGNGLDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFE 126

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
              +L+  + ERK+ DP+ SYTA L  S    + +K+ EE  E +LA  V  R    +E 
Sbjct: 127 VWSELQSTVRERKTGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEW 186

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL +H+ V L+  G+    V+E LRKR 
Sbjct: 187 ADLFFHIAVALEKTGVSWGEVMEILRKRQ 215


>UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum
           sp. NBC37-1 RepID=A6Q6T8_SULNB
          Length = 222

 Score =  228 bits (583), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +DW K + L+P I Q A + +VLML YMN EA + TL +G   +FSR+KQR+W KGE+SG
Sbjct: 3   IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115
           +   V  +  DCD DT+++     G  CH G  SCF               DT   +  +
Sbjct: 62  HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121

Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
             L   + ERK+A  E  S+T KL     + +  K+ EE  E  +A       ++  E++
Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV L  + +    V + L +R
Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207


>UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS
          Length = 257

 Score =  228 bits (583), Expect = 7e-59,   Method: Composition-based stats.
 Identities = 79/244 (32%), Positives = 114/244 (46%), Gaps = 43/244 (17%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M   Q   E+ +    GL+P I QH  +G +LM+ +MN E+L  T E  +  +FSR++Q+
Sbjct: 1   MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFL---- 115
           LW KGE SG+F  V  I  DCD D +++     G   CH G  SCF        +     
Sbjct: 60  LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119

Query: 116 ------------------------------YQLEQLLAERKSADPETSYTAKLYASGTKR 145
                                           L QL+ ERK A+ +TSY + LY  G  +
Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179

Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           I +KVGEEGVET +AA          +  +L  E +DL +H +V+L    L+   +I+ L
Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239

Query: 199 RKRH 202
            +R 
Sbjct: 240 GRRQ 243


>UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT
          Length = 230

 Score =  228 bits (582), Expect = 9e-59,   Method: Composition-based stats.
 Identities = 85/206 (41%), Positives = 116/206 (56%), Gaps = 8/206 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +       +   + L PV+ Q    G+VLM+GYMN EA  +T+E G+VTFFSR+++RLWT
Sbjct: 2   DDAILRTLFPDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWT 61

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT--------AHQWLFL 115
           KGE+SG+FL +VS+  DCD DTLL L  P GPTCH GT SCF              +  L
Sbjct: 62  KGESSGHFLRLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETL 121

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             L   +A R+  DPETSY A+L +     + +K+ EE  ET  A    D     +E +D
Sbjct: 122 GDLAGTIALRRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMAD 181

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           L++HLLV ++        V+  L KR
Sbjct: 182 LLFHLLVAMERTRTPWEEVVGVLEKR 207


>UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria
           RepID=HIS2_AQUAE
          Length = 205

 Score =  228 bits (581), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 75/204 (36%), Positives = 116/204 (56%), Gaps = 10/204 (4%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +L +   +GL+PVI Q   +GEV ML Y N EA+ KTLE+G   ++SR+++++W KGETS
Sbjct: 3   KLKF-NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT--------AHQWLFLYQLE 119
           G    V+ +  DCD D L+ +        CH G  +CF              +  L +L+
Sbjct: 62  GELQKVIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPRLQ 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            ++ E+     E SYTAKL + G +R+ QK GEE VET +A    ++ E+  E++D++Y 
Sbjct: 122 DVIREKIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADMLYT 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
            LV L   G+D+  V+E L +R +
Sbjct: 182 FLVSLSVSGIDIKEVMEELIRRFK 205


>UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_THET2
          Length = 214

 Score =  226 bits (577), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 81/202 (40%), Positives = 118/202 (58%), Gaps = 6/202 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGE
Sbjct: 3   LSAVRFD-EKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQL 121
           TSG+   VV +  DCD D ++    P GP CH G  +CF              + Q+   
Sbjct: 62  TSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYAT 121

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + ER    PE SY A+++ +G  RI +K+GEE  E  LAA   +  EL +EA+DL++HLL
Sbjct: 122 IKERLRTLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLL 181

Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203
           + L + GL    + + L +RH+
Sbjct: 182 LTLAELGLTPEDLAKTLWERHR 203


>UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP
           cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NG19_KYTSD
          Length = 244

 Score =  225 bits (574), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 95/222 (42%), Positives = 123/222 (55%), Gaps = 31/222 (13%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
            +   GL+  +VQ A +  VLM+G+M+  AL+ T  +G+VTF+SR++   W KGETSGN 
Sbjct: 22  TDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVKGETSGNT 81

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG------------------------- 106
           L+VVS+  DCD D +LV+A P GPTCH G +SCF                          
Sbjct: 82  LDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAASGAGGDA 141

Query: 107 ------DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
                  T      +  L + +AER    P  SYT  L+  GT+RIAQKVGEEGVETALA
Sbjct: 142 PASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEEGVETALA 201

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                  EL  E++DL+YHL+VLL D+GL L  V   LR R 
Sbjct: 202 GVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243


>UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4L5_GEMAT
          Length = 207

 Score =  225 bits (573), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 80/204 (39%), Positives = 111/204 (54%), Gaps = 5/204 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M +      LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++  
Sbjct: 1   MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG TSG+   V+S+A DCD D +L      GP CH GT+SCF DTA     +  L+ 
Sbjct: 60  LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119

Query: 121 LLAERKS---ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
            +A R+     D   SYT +L         +K+GEE VE A A    D    T E +DL+
Sbjct: 120 TIAARQQSLRDDERPSYTQRLLT-DRNLRLKKLGEEAVELATACVDGDVERATEETADLL 178

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YH LV L+  G  L  V   L +R
Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202


>UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes
           RepID=C6W0Y7_DYAFD
          Length = 213

 Score =  225 bits (573), Expect = 9e-58,   Method: Composition-based stats.
 Identities = 104/211 (49%), Positives = 133/211 (63%), Gaps = 12/211 (5%)

Query: 5   QQRRELDWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    +D+ K  DGL+P ++Q   +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT
Sbjct: 3   ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF--------- 114
           KGETSGNFL V  IA DCD DTLL+ A P GP CH G  +CFG+   Q            
Sbjct: 63  KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122

Query: 115 --LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
              Y  ++++ ERK    + SYT+ L+  G  +IAQKVGEE VE  + +   D     NE
Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            SDL++HLLVLL+ + +DL  VI+ LR RHQ
Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213


>UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera
           aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR
          Length = 204

 Score =  225 bits (573), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 91/203 (44%), Positives = 125/203 (61%), Gaps = 1/203 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT  Q  +L+W+K + L+P+IVQ   S E+LM GY N ++L  TL+  K+TFFSRTK R
Sbjct: 1   MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LWTKGETS N+L V+ I PDCD D+LL L   IG TCH    SCF    +  +      +
Sbjct: 61  LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120

Query: 121 LLAE-RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            + +  K  +  TSYT+ LY  G  +I+QKVGEE VE  +AA   D+  +  E +DL+YH
Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVL     +    +I+ L+KR+
Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203


>UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
           n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD
          Length = 202

 Score =  222 bits (565), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 70/198 (35%), Positives = 102/198 (51%), Gaps = 5/198 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+   W KG 
Sbjct: 4   LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSGN   VV++  DCD D +L      GP CH GT +CFG      L             
Sbjct: 63  TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAP 122

Query: 127 SADPET---SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +  P+    SYT +L         +K+GEE  E   A    D      EA+D++YH+LV 
Sbjct: 123 AERPDDAPPSYTRRLLE-DRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVA 181

Query: 184 LQDQGLDLTTVIENLRKR 201
           ++  GL L  V   L +R
Sbjct: 182 VRPLGLSLDDVKAVLARR 199


>UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=2 Tax=Francisella philomiragia
           RepID=B0TY40_FRAP2
          Length = 207

 Score =  216 bits (551), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 102/201 (50%), Positives = 136/201 (67%), Gaps = 3/201 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + W+K D L+P I+Q A+   VLMLGYM+ E+L+KTLE GKVTF+SR+K+RLWTK
Sbjct: 4   KIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRLWTK 63

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL--YQLEQLL 122
           GE SGNFL +  IA DCDND++L+ A P GPTCH G+ SCF             +LE+L+
Sbjct: 64  GEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLEKLI 123

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMYHLL 181
           AE+K   PE SY   L+  G  RIAQKVGEEGVE  +AA   D   EL +E +DL++HLL
Sbjct: 124 AEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLFHLL 183

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
           VLL+++G+ L  + + L  R+
Sbjct: 184 VLLREKGISLEQICQKLVSRN 204


>UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8HTA8_CHLRE
          Length = 308

 Score =  215 bits (548), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 73/226 (32%), Positives = 117/226 (51%), Gaps = 31/226 (13%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L W+K + L+ VIVQH  +GEV+M  + +  A+ +TL++G  TF+SR++   W K
Sbjct: 67  SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107
           GETSG+F+NV ++  DCD D+++ L++PIGP CH G  +C+                   
Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185

Query: 108 -----TAHQWLFLYQLEQLLAERKSA------DPETSYTAKLYASGTKRIAQKVGEEGVE 156
                       L  LE+ +A+R+ A        + S+TA+L  +  + + +K+ EE  E
Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLLGN-PELLCKKIREEAGE 244

Query: 157 TALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                     R    +E +DL+YH +VL   QG+ +  V+  LRKR
Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290


>UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta
           RepID=HIS2_ARATH
          Length = 281

 Score =  208 bits (530), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 74/219 (33%), Positives = 112/219 (51%), Gaps = 21/219 (9%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +     + W+   GL   I Q+  +G VLM G++N EAL  T+ S K TFFSR++  L
Sbjct: 51  KVDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTL 109

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL------ 115
           WTKGETS NF+N++ +  DCD D+++ L  P GPTCH G  +C+  +    L        
Sbjct: 110 WTKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGN 169

Query: 116 -------YQLEQLLAERKSA---DPET--SYTAKLYASGTKRIAQKVGEEGVETALAAT- 162
                  Y LE ++++RK       E   S+T +L       +  K+ EE  E       
Sbjct: 170 KLALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADELCRTLED 228

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             +     +E +D++YH +VLL  +G+ +  V+E LRKR
Sbjct: 229 NEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267


>UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU
          Length = 284

 Score =  207 bits (528), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 70/220 (31%), Positives = 112/220 (50%), Gaps = 25/220 (11%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+  I Q   +G +LM G+ + +A+  TL + K TF+SR++  LW K
Sbjct: 45  AFLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCK 103

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL----------- 113
           GETSGNF+ V S+  DCD D+L+ L  P GPTCH G  +C+                   
Sbjct: 104 GETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRH 163

Query: 114 -------FLYQLEQLLAERK----SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-A 161
                   LY+LE  +  R+    + D + S+T +L  +  + + +K+ EE  E      
Sbjct: 164 AAEEALTTLYELEATIEARRVEAVADDVKPSWTRRLLDN-PELLCKKIREEAGELCQTWE 222

Query: 162 TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +   TNE +D++YH +V+L  QG+ ++ V+  LR+R
Sbjct: 223 ENEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  199 bits (506), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 68/203 (33%), Positives = 104/203 (51%), Gaps = 9/203 (4%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT++   E+  ++ DGL   +V        L L Y + +++ K ++ G+  ++SR++  
Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLE 119
           +W KGETSGN   ++ I+ DCD+D L  +        CH  T SCFG+  H    L  LE
Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHG---LVGLE 249

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            LL +R    PE SYT +L+ + +  +  K+ EE  E   A     + EL+ EA+DL Y 
Sbjct: 250 SLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L  L    + L  V  NL  +H
Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328


>UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2
           Tax=Campylobacter RepID=B9D5P8_WOLRE
          Length = 329

 Score =  198 bits (504), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P +VQ + SGEVLML YMN EAL+ +L++G   +FSRTK R+W KGE S
Sbjct: 2   KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107
           GN   +  I  DCDNDT+L+     G   CH G  SCF                      
Sbjct: 62  GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121

Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
                      +  + ++   + +RK +ADP+TSY A L+  G   I +KVGEE  E  +
Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181

Query: 160 AATVHD 165
           A     
Sbjct: 182 ACKDAS 187



 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 13/35 (37%), Positives = 18/35 (51%)

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E+  EA+DL +H LV L   G+    V   L +R
Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315


>UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM
           16069 RepID=C7RAI7_KANKD
          Length = 412

 Score =  197 bits (500), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 69/201 (34%), Positives = 104/201 (51%), Gaps = 6/201 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L E     LD++K   L+P IVQ   +G VLML Y  PE+L   +   K  +FSR++  L
Sbjct: 216 LDEAVMACLDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNEL 274

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG TSGN   +++I  DCD DTL+      G  CH    SCF   +  +  L  L+++
Sbjct: 275 WEKGLTSGNQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANF-DLDVLDRV 333

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
             +R  +   TS++ KL AS      +K+ EE  E   A    D+ E+  EA+DL++  L
Sbjct: 334 FEQRMQSQEVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFAL 389

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
              + +G+  + +I  L  R+
Sbjct: 390 ARAKSKGVAASDIINELGARN 410


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  189 bits (481), Expect = 4e-47,   Method: Composition-based stats.
 Identities = 62/191 (32%), Positives = 94/191 (49%), Gaps = 10/191 (5%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
             ++ DGL+P +V        L L Y + E++ + L++    + SR +  LW KG TSG+
Sbjct: 202 KSDRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGD 259

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              +V I+ DCDND L  +    G  CH   S CFGD       L +LE  L  RK + P
Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFGDL----KGLAKLESTLLSRKQSAP 315

Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190
             SYTA+L++   K +  K+ EE  E   A   +    +  EA+DL+Y  L      G+ 
Sbjct: 316 AGSYTARLFS-DEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVT 371

Query: 191 LTTVIENLRKR 201
           L  + ++L  +
Sbjct: 372 LADIEKSLDAK 382


>UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira
           pseudonana RepID=B8BUA9_THAPS
          Length = 272

 Score =  188 bits (479), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 58/198 (29%), Positives = 95/198 (47%), Gaps = 13/198 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +  ++ DGL   +V    SGE L L Y + E++   L+SG+  ++SR++  LW KG+TSG
Sbjct: 59  VKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTSG 117

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
           +F  +  +  DCD D L       G      CH  T +C+G+       L  LE  L +R
Sbjct: 118 HFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEP----RGLRHLEGTLQQR 173

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
               P  SYT +L+      +  K+ EE  E + A     +  +  E +D++Y  +V   
Sbjct: 174 LKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRAA 229

Query: 186 DQGLDLTTVIENLRKRHQ 203
             G+ +   +E L +R +
Sbjct: 230 KAGVSIDDAVEELDRRTR 247


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  188 bits (477), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 66/209 (31%), Positives = 104/209 (49%), Gaps = 17/209 (8%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +        ++ DGL   +V     G  L L Y + E++ ++L +G+  + SR +  L
Sbjct: 191 VAKLVMANATSDRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-L 248

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE+SG+   +VS++ DCD+D L  +    G   CH  T +CFGD    +  L +L++
Sbjct: 249 WYKGESSGDIQELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFGD----YRGLSKLQK 304

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L  RK + P+ SYTA+L+ +  + +  K+ EE  E   A T   +  +  EA+DL Y  
Sbjct: 305 TLQSRKESAPQGSYTARLF-NDAQLLRAKILEEATELCDATT---KEHIAFEAADLFYFA 360

Query: 181 LVLLQDQGLDLTTVIENLR------KRHQ 203
           L      G+ L  V  NL       KR Q
Sbjct: 361 LTKCVAAGVSLEDVERNLDAKSIKVKRRQ 389


>UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira
           RepID=B5VZW9_SPIMA
          Length = 200

 Score =  187 bits (476), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 17/197 (8%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+ + +Q  ++G VL LG MN EAL KTL + ++ +  +++  LW    
Sbjct: 21  IDKIRYD-DQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHP-- 77

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
                + + SI+ D   + L+         C    +   G        L  L +++ +R+
Sbjct: 78  ----DIILESISYDYRGNFLVAGV----AYCPSELNGSGGH------TLAGLFRVICDRR 123

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
                 SYT +L+A G  +I +K+GEE  E  +A    +   + +E +DL YH LV L  
Sbjct: 124 DHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAY 183

Query: 187 QGLDLTTVIENLRKRHQ 203
             +DL  V E L  R Q
Sbjct: 184 HQVDLRKVYEQLEARRQ 200


>UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces
           RepID=HIS2_SCHPO
          Length = 417

 Score =  185 bits (471), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 63/203 (31%), Positives = 101/203 (49%), Gaps = 11/203 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L +      + ++ DGL   +V + + G  L L Y + E++ ++L++G   + SR +  L
Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KG +SG   +++ I  DCD D L  +    G   CH  T  CFG        L QLE+
Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQA----SGLCQLEK 308

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L +RK+  PE SYTA+L++   K +  K+ EE  E   A T   +  +  E +DLMY  
Sbjct: 309 TLIDRKNNAPEGSYTARLFS-DPKLLRAKIMEEAEELCDATT---KENVIWEMADLMYFA 364

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +      G+ L  +  +L  +H+
Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  182 bits (462), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 61/208 (29%), Positives = 93/208 (44%), Gaps = 13/208 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L  ++TDGL    V  +     L L Y +P ++ K++ +G   + SR +  L
Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CHKGTS-SCFGDTAHQWLFL 115
           W KGE+SG    VVSI  DCD+D +         T     CH      CF         L
Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENREGCFSSA----TGL 307

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            +LE  L  R    P  SYTA+L+ +    +  K+ EE  E A A   +D+  +  EA+D
Sbjct: 308 AKLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAAD 365

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+Y  L      G+ L  +  +L  + +
Sbjct: 366 LIYFALTKCVSAGIGLEEIEASLDAKAK 393


>UniRef50_A0YJX3 Phosphoribosyl-ATP
           pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase
           n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN
          Length = 198

 Score =  175 bits (445), Expect = 6e-43,   Method: Composition-based stats.
 Identities = 52/197 (26%), Positives = 88/197 (44%), Gaps = 13/197 (6%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ +    GL+P I+Q  + G VL L +M+ ++L KT E  +V     +   L +   
Sbjct: 15  IDKIRY-NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLL 73

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
            +G   +     P C +  +LV    I    ++               L ++ +++ +R+
Sbjct: 74  ITGWRYD-----PACQSLLILVECGSIAEPQNE-------FAQVSSNLLSEVFEVICDRR 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
               E SYT KL A G  +I +K+GEE  E  +A    D   + +E +DL YH LV +  
Sbjct: 122 DHPQEDSYTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAY 181

Query: 187 QGLDLTTVIENLRKRHQ 203
              DL  V   L +R +
Sbjct: 182 HRADLRQVYRKLAERRR 198


>UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN
          Length = 477

 Score =  174 bits (441), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 10/198 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
              + L  ++ D L   +V    +G  L L Y + E++   + SG+  ++SR++  LW K
Sbjct: 244 AFVKCLRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKK 302

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE+SGN   ++ I  DCD+D L    N  G   CH  T +C+G        L  LE +L 
Sbjct: 303 GESSGNAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHD----GGLRALESMLF 358

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R    P  SYT +L+    + +  K+     E    A      ++  EA+D+MY  +V 
Sbjct: 359 SRHENAPAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVR 414

Query: 184 LQDQGLDLTTVIENLRKR 201
               G  L+ V   L KR
Sbjct: 415 CVAAGCKLSDVERMLDKR 432


>UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms
           RepID=HIS3_PELLD
          Length = 137

 Score =  174 bits (441), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 49/133 (36%), Positives = 73/133 (54%), Gaps = 6/133 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + ++   GL+P IVQ   +G+VLM+ +MN E+L+ TLE  K  ++SR++ +LW K
Sbjct: 10  SFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKLWLK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SGN  +V  I  DCD DTL++  + IG  CH G  SCF     +   +      + +
Sbjct: 69  GESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYRRVLENGNM-----EICD 123

Query: 125 RKSADPETSYTAK 137
               DPE  Y  K
Sbjct: 124 TLMFDPEEVYGKK 136


>UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4CVB3_9BACT
          Length = 128

 Score =  171 bits (434), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 52/131 (39%), Positives = 71/131 (54%), Gaps = 5/131 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L +   DGL+P IVQ   +  VLM+ +MN  +L+ TL++G + ++SR++Q+ W KGE
Sbjct: 3   LPNLKY-TADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSG+   VV  A DCD DTLL     IG  CH G  SCF                + E K
Sbjct: 62  TSGHTQKVVRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSPEGTPL----EITEEK 117

Query: 127 SADPETSYTAK 137
             DPE +Y +K
Sbjct: 118 LFDPEKTYASK 128


>UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_CHLP8
          Length = 137

 Score =  168 bits (427), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +     + ++   GL+P IVQ   +G+VLM+ +MN E+L  TLE  K  ++SR++ +LW 
Sbjct: 9   KSFLETVKFDDR-GLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE+SGN  +V  I  DCD DTLL+  +  G  CH G  SCF         +      + 
Sbjct: 68  KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQM-----EIC 122

Query: 124 ERKSADPETSYTAK 137
           +    DPE  Y  K
Sbjct: 123 DTLMFDPEEVYGKK 136


>UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=C4XTP1_DESMR
          Length = 124

 Score =  168 bits (425), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 58/125 (46%), Positives = 73/125 (58%), Gaps = 7/125 (5%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
           D+ K  GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG TSG+
Sbjct: 5   DFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGGTSGH 64

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
              V S+  DCD DT+LVL   I G  CH+G  SCF              +     K  D
Sbjct: 65  VQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFFTEITSDG------ERTCSPKVFD 118

Query: 130 PETSY 134
           P+  Y
Sbjct: 119 PKEVY 123


>UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT
          Length = 116

 Score =  167 bits (424), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 2/108 (1%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L +   D L+P I Q    G VLM+ +MN E++ KTL +G+  ++SR++ +LW KG
Sbjct: 7   WFEKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKG 65

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112
            TSG+   V  +  DCD DT+L+    IG   CH G  SCF +    +
Sbjct: 66  ATSGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113


>UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria
           RepID=HIS3_RHOPT
          Length = 151

 Score =  167 bits (423), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 42/127 (33%), Positives = 70/127 (55%), Gaps = 2/127 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+ V+   A +G+VLM+ +MN EALD+T+++G+  ++SR+++RLW KGETSG+
Sbjct: 26  KFD-AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRLWKKGETSGH 84

Query: 71  FLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
              V+ +  DCD D + +  +   G  CH G  SCF     +      +       +  D
Sbjct: 85  IQKVLEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLIETDAERKFD 144

Query: 130 PETSYTA 136
           P+  Y  
Sbjct: 145 PDKVYGK 151


>UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_RHOPS
          Length = 147

 Score =  167 bits (423), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 1/124 (0%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +   A SGEVLM+ +MN EAL+KT++SG+  ++SR+++RLW KGE+SG+
Sbjct: 23  KFDAA-GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGH 81

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              V+ I  DCD D + +     G  CH G  SCF     +      L  ++   +  DP
Sbjct: 82  VQRVLEIRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTMVDADRLFDP 141

Query: 131 ETSY 134
              Y
Sbjct: 142 AKIY 145


>UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria
           RepID=B8J3P0_DESDA
          Length = 137

 Score =  166 bits (422), Expect = 3e-40,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 7/129 (5%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
                + + GL+P I Q   SGEVLML YMN EA  KTLE+G+  ++SR+++++W KG T
Sbjct: 14  EAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGT 73

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           SG+   V+++  DCD+DT+L+  + + G  CH G  +CF                     
Sbjct: 74  SGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE------WKDGAVSECAPM 127

Query: 127 SADPETSYT 135
             DP+  Y 
Sbjct: 128 VFDPQKVYG 136


>UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_STRTD
          Length = 112

 Score =  166 bits (421), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 47/106 (44%), Positives = 65/106 (61%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD++K  GL+PVIV    +G+VLML YMN  +   TLE+ ++ ++SR++  LW KG TS
Sbjct: 5   KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           G+F +V SI  DCD DTLL+     G  CH G  SCF    +    
Sbjct: 65  GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYDDNQ 110


>UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3
          Length = 140

 Score =  166 bits (421), Expect = 4e-40,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 70/133 (52%), Gaps = 5/133 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + ++K +GL+P I Q   +G+VLML YMN E+L+ TL+  K  ++SR++Q LW K
Sbjct: 10  KLMDIVRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           G TSGNF  V+ I+ DCD D +L+     G  CH G  SCF                + +
Sbjct: 69  GATSGNFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVENDNSSLS----ICD 124

Query: 125 RKSADPETSYTAK 137
           +   D E  Y   
Sbjct: 125 KLVFDAEEVYGKS 137


>UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R0U5_9PLAN
          Length = 310

 Score =  164 bits (415), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 41/128 (32%), Positives = 67/128 (52%), Gaps = 1/128 (0%)

Query: 11  DWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           D+ +    L+P I Q   +GEVLM+ +MN E+  +T+ +G+  ++SR++ +LW KGE SG
Sbjct: 173 DFSRGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESG 232

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           +   V  +  DCD DT+L+  + +G  CH+G  SCF             E+L+       
Sbjct: 233 HMQTVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYK 292

Query: 130 PETSYTAK 137
              S+   
Sbjct: 293 NPKSHAKS 300


>UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae
           RepID=HIS3_FRAAA
          Length = 132

 Score =  164 bits (415), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 46/108 (42%), Positives = 62/108 (57%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
               GL P I Q   +GEVLMLG+M+ EAL +TL +G+ T++SR++   W KG+TSG+  
Sbjct: 18  RNDAGLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEYWVKGDTSGHQQ 77

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
            V S+A DCD D +LV  + IGP CH GT +CF               
Sbjct: 78  WVRSVALDCDGDAVLVRVDQIGPACHTGTRNCFVADPLPTRVGDPGVT 125


>UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota
           RepID=HIS3_HALWD
          Length = 132

 Score =  163 bits (414), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 53/131 (40%), Positives = 73/131 (55%), Gaps = 10/131 (7%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ +  +DGL+P I Q A SGEVLML Y++P AL +T E+G+  ++SR+++ LW 
Sbjct: 11  DDAEIEIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWK 69

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGETSG+  ++  I  DCD DT+L L    G  CH G  SCF  T               
Sbjct: 70  KGETSGHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRTLDGTEVT-------- 121

Query: 124 ERKSADPETSY 134
             +  DPET Y
Sbjct: 122 -ERVFDPETVY 131


>UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_METTH
          Length = 138

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             + L+  + Q   +GEVLM+ YMN EAL +TLE+G   ++S ++ +LW KGE+SG+   
Sbjct: 19  NGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQR 78

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
           V  +  DCD D +++     G  CH G  SCF  +        + + +    K  DPE  
Sbjct: 79  VKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----KVFDPEEI 134

Query: 134 YT 135
           Y 
Sbjct: 135 YG 136


>UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria
           RepID=HIS3_SALRD
          Length = 127

 Score =  163 bits (412), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 7/133 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +++      D+   DGL+P IVQ A + +VLM+ YM  E L +TL++G++ ++SR++Q  
Sbjct: 1   MSDPLLDAADF-TDDGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQER 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG+TSG+   V     DCD DTLL   +  G  CH G  SCF   A            
Sbjct: 60  WVKGQTSGHTQTVEEARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAADDG------WT 113

Query: 122 LAERKSADPETSY 134
               K  DP+  Y
Sbjct: 114 TDGEKVFDPDAVY 126


>UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria
           RepID=Q2SLC2_HAHCH
          Length = 139

 Score =  163 bits (412), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 45/111 (40%), Positives = 66/111 (59%), Gaps = 1/111 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                EL +    GL+PVI Q A +  +LM  +MN EAL+KT+ + ++T++SR++QRLW 
Sbjct: 21  PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           KGETSG+   +VS++ DCD D +L L +  G  CH G  +CF         
Sbjct: 80  KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFYLQVEPDKQ 130


>UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria
           RepID=HIS3_DINSH
          Length = 119

 Score =  162 bits (410), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 45/115 (39%), Positives = 68/115 (59%), Gaps = 1/115 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             L ++   GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q  W KGE+
Sbjct: 6   ASLRYD-DQGLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGES 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           SG+   +V +  DCD D LL+     GP CH    +CF         +  +  ++
Sbjct: 65  SGHVQTLVEMRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119


>UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales
           RepID=C4Z0A8_EUBE2
          Length = 362

 Score =  162 bits (410), Expect = 7e-39,   Method: Composition-based stats.
 Identities = 51/112 (45%), Positives = 71/112 (63%), Gaps = 1/112 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +   ++L  +  +GL+PV+VQ  V+ EVLML YMN EA +KTLE+G +T++SR++Q L
Sbjct: 251 KADISFKDLKLD-ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQEL 309

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           W KG TSG+F  V S+  DCDNDT+L     +G  CH G  +CF      W 
Sbjct: 310 WVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWN 361


>UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae
           RepID=HIS3_ACIC1
          Length = 142

 Score =  162 bits (410), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 45/99 (45%), Positives = 62/99 (62%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
               GL P + Q   +GEVLM+G+M+ EAL +TL +G+ T++SR++Q  W KGETSG+  
Sbjct: 18  RDEHGLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEYWVKGETSGHQQ 77

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111
            V S+A DCD DT+LV  + IG  CH G  +CF      
Sbjct: 78  WVKSVALDCDGDTVLVKVDQIGAACHTGDRTCFDAGQLP 116


>UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R0N1_9RHOB
          Length = 156

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 47/138 (34%), Positives = 69/138 (50%), Gaps = 5/138 (3%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L ++   + D    +GL+   V    SGE+LM+GYMN E+L +T+E+G+  ++SR++Q  
Sbjct: 21  LGDELCPKFD---ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           W KG TSG    V+ I  DCD D +   V  +  G TCH G  SCF    +         
Sbjct: 78  WKKGGTSGQVQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWL 137

Query: 120 QLLAERKSADPETSYTAK 137
           +        DP+  Y  K
Sbjct: 138 EKTEVAPVYDPQEVYGKK 155


>UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria
           RepID=HIS3_BURS3
          Length = 138

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 47/132 (35%), Positives = 71/132 (53%), Gaps = 4/132 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                ++ W+  +GL+PVI Q A + +VLM  +MN EAL KT+E+ +  ++SR+++RLW 
Sbjct: 9   PAWLDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWF 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+  +V  +  DCD D +L+    + G  CH G  SCF       +       + 
Sbjct: 68  KGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVE 127

Query: 123 AERKSADPETSY 134
              K  DPE  Y
Sbjct: 128 PVLK--DPEHIY 137


>UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured
           crenarchaeote RepID=Q702A1_9CREN
          Length = 115

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 42/109 (38%), Positives = 66/109 (60%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   +LD+ K DGL+PV+VQ   + ++LML Y N  A++ T+++G   F+S ++ +LW 
Sbjct: 7   DEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKLWM 66

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112
           KGE SGN   V  I  DCD D++L L +   P CH G  +CF +  +  
Sbjct: 67  KGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHNRLYPN 115


>UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria
           RepID=HIS3_THICR
          Length = 147

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 48/131 (36%), Positives = 72/131 (54%), Gaps = 7/131 (5%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E  ++++ ++  +GL+P I Q   S EVLM+ +MN  AL +TLE+G+V ++SR++Q  W 
Sbjct: 22  EAVKKQVKYD-DNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR 80

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE SG    +  +  DCD D +L+L +  GP CH G  SCF    H          ++ 
Sbjct: 81  KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPII- 139

Query: 124 ERKSADPETSY 134
                DPE  Y
Sbjct: 140 -----DPEALY 145


>UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria
           RepID=HIS3_CORJK
          Length = 127

 Score =  160 bits (406), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 60/108 (55%), Gaps = 1/108 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       + +   DGL+P IVQ   +G+VLM+ +MN  AL  TL + K T++SR++Q  
Sbjct: 19  LDPAIAERVRF-NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
           W KGETSG+   V  +  DCD DT+L+     G  CH G  +CF    
Sbjct: 78  WIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADR 125


>UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms
           RepID=HIS3_SOLUE
          Length = 126

 Score =  160 bits (405), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 7/130 (5%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            LD+ K+DGL+  ++Q   SG VLM+GYMN EA +KT+E+G  TF+SR++++LW KGE+S
Sbjct: 2   NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           G+ L V  I+ DCD D +LV     GP  CH+G  SCF         L   E  +A+  +
Sbjct: 62  GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRR------LDAGEWKVADNPT 115

Query: 128 ADPETSYTAK 137
            DP   Y  K
Sbjct: 116 YDPGAVYGGK 125


>UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria
           RepID=A4GIE4_9BACT
          Length = 132

 Score =  160 bits (405), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 41/94 (43%), Positives = 64/94 (68%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q   +GEVLM+ +MN  +L +TL +G++ ++SR+++ LW KG+TSG+   +
Sbjct: 15  ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           + +  DCD D++LVL +  G  CH+GT SCF   
Sbjct: 75  IELRYDCDADSILVLVDQSGAACHEGTRSCFTRR 108


>UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_GEOSF
          Length = 126

 Score =  160 bits (405), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++D++K  GL+P ++Q   SGEVLM+ +M+ + LD TL+ GK  FFSRT+ + W KGE
Sbjct: 1   MIKIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
            SGN   V+ +  DCD DT+++     GP  CH G  SCF       +     + +    
Sbjct: 61  ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFY------VKWEDGQWVEHSN 114

Query: 126 KSADPETSY 134
              DP   Y
Sbjct: 115 PLFDPNEVY 123


>UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria
           RepID=HIS3_SILST
          Length = 129

 Score =  160 bits (404), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 62/108 (57%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P I Q   SGE+LM+ +MN E++ KTLE+G+VT++SR++Q  W KGE+SG+   
Sbjct: 21  NEAGLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQE 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           +V +  DCD D LL +    GP CH    SCF            +  +
Sbjct: 81  LVELRVDCDRDALLAMVRQTGPACHTNRRSCFYTAIRDGEEHEIMTPI 128


>UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC
           49814 RepID=C6XNB8_HIRBI
          Length = 139

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 59/108 (54%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+  I Q   S EVLML +MN +AL  T+E+G+  ++SR++ +LW KG+TSG +  
Sbjct: 30  NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           V SI  DCD D +L+        CH G  SCF         L   E  
Sbjct: 90  VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYRQITDLSTLNPTEDK 137


>UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM
          Length = 151

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 46/114 (40%), Positives = 63/114 (55%), Gaps = 1/114 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               +L +    GL+P + Q A +G+VLML +MN  A++KTLE+G++T+FSR++  LW K
Sbjct: 33  DVIEQLAY-NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVK 91

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           G  SGN   +V    DCD D LL      G  CH G  SCF   A+       L
Sbjct: 92  GLASGNHQQLVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVYL 145


>UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca
           ATCC 27029 RepID=D1SGQ9_9ACTO
          Length = 444

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 43/96 (44%), Positives = 59/96 (61%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
              DGL+  +V+   SGEVLM+ +M+ EAL +TL +G+ T++SR++   W KG TSGN  
Sbjct: 339 RTPDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEYWVKGATSGNHQ 398

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            V S+A DCD D LLV    +G  CH G  +CF   
Sbjct: 399 YVRSVALDCDGDALLVSVEQVGAACHTGQRTCFFTE 434


>UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268
           RepID=C8PI34_9PROT
          Length = 336

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 54/135 (40%), Positives = 65/135 (48%), Gaps = 3/135 (2%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P IVQ A  G VLML YMN EAL  TL +G   +FSR+K R+W KGE S
Sbjct: 2   KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWL-FLYQLEQLLAERK 126
           G+   V S   DCDND LL+     G   CH G  SCF                      
Sbjct: 62  GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKEISLQKCGENVGSSSTCGAI 121

Query: 127 SADPETSYTAKLYAS 141
           +     S T  L   
Sbjct: 122 NFAEHGS-TTSLAQK 135



 Score = 66.0 bits (160), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 28/132 (21%), Positives = 46/132 (34%), Gaps = 24/132 (18%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVG 151
                +             +  L ++  +  +RK    P  SY A LYA G     +K+ 
Sbjct: 194 DAAAQNSTL--ENSAEKGPYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251

Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190
           EE  E ALA     R EL  + +              D++Y        LL+ L    + 
Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311

Query: 191 LTTVIENLRKRH 202
              +++ L +R 
Sbjct: 312 PDALLDELARRQ 323


>UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria
           RepID=B9QYY7_9RHOB
          Length = 159

 Score =  159 bits (402), Expect = 7e-38,   Method: Composition-based stats.
 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            +++ DGL+  +V    + EVLM+GYMN EAL +T+E+G+  ++SR+++  W KGETSG 
Sbjct: 32  KFDQ-DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQ 90

Query: 71  FLNVVSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D L+V       G TCH G  SCF                + + K  
Sbjct: 91  IQKVQEILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANVEKEKVY 150

Query: 129 DPETSYTA 136
           DP+  Y  
Sbjct: 151 DPKKVYGK 158


>UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F746
          Length = 123

 Score =  158 bits (401), Expect = 7e-38,   Method: Composition-based stats.
 Identities = 48/111 (43%), Positives = 67/111 (60%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T +  REL    +DGL+PVIVQ   + EVLM+ +M+ EA+++TL +G   ++SR++Q  W
Sbjct: 13  TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
            KGETSGN   V S++ DCD D LL+     GP CH  T +CF        
Sbjct: 73  VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCFTGRTISAN 123


>UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_RALEJ
          Length = 135

 Score =  158 bits (401), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 49/137 (35%), Positives = 72/137 (52%), Gaps = 4/137 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   ++ W+  +GL+PVIVQ   + +VLM  +MN +AL KT E G+  F+SR+++RL
Sbjct: 1   MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE SG+   V  +  DCD D +L+    +    CH G  SCF             + 
Sbjct: 60  WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEG--DAESGDW 117

Query: 121 LLAERKSADPETSYTAK 137
              E    DP   YTAK
Sbjct: 118 QTVEPVLKDPSQIYTAK 134


>UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria
           RepID=HIS3_CHRSD
          Length = 146

 Score =  157 bits (397), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 45/104 (43%), Positives = 62/104 (59%), Gaps = 1/104 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T        W    GL+P I Q   SGEVLM+ +MN  AL++TL +G+V ++SR++ + W
Sbjct: 19  TRDLLDAARWNDA-GLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
            KGE+SG    +V+   DCD DTLL+  +  GP CH G  SCF 
Sbjct: 78  RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFY 121


>UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_PSEU2
          Length = 130

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 41/130 (31%), Positives = 68/130 (52%), Gaps = 3/130 (2%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ W  +DGL+P I Q   +G VLM+ +MN EAL  T    +  ++SR++ +LW 
Sbjct: 2   KDWLDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+   +  +  DCD D ++++   IG   CH G  SCF    ++      ++ +L
Sbjct: 61  KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYR-VYEKSGWKTVDPVL 119

Query: 123 AERKSADPET 132
            +  +  P  
Sbjct: 120 KDPDAIYPAG 129


>UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class)
           RepID=HIS3_CLAMS
          Length = 138

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 46/107 (42%), Positives = 65/107 (60%), Gaps = 1/107 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            +       +   DGL+P ++Q   + EVLMLGYM+ EAL +TL +G+VTF+SR++   W
Sbjct: 16  VDGILARASF-ADDGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYW 74

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
            KG+TSG+   V   A DCD DT+LV  + +G  CH GT +CF    
Sbjct: 75  RKGDTSGHGQYVRDAALDCDGDTVLVQVDQVGVACHTGTRTCFDADH 121


>UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium
           HTCC2255 RepID=Q0FGM5_9RHOB
          Length = 120

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 43/116 (37%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L ++  +GL+P +VQ   + EVLM+ +MN  +L+KT E+   TF+SR+++ LW KG 
Sbjct: 6   ISSLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCLWVKGL 64

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           TSGN   V  +  DCD D +L+L  P GP CH    +CF     +      L    
Sbjct: 65  TSGNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTELEEGSENIILNPET 120


>UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria
           RepID=HIS3_ACIAC
          Length = 141

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 53/134 (39%), Positives = 69/134 (51%), Gaps = 11/134 (8%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               E+ W+   GL+PVI Q A +G+VLM  +MN EAL KT E G+  +FSR++ RLW K
Sbjct: 14  SWLDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFK 72

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           GE SG+   V  I  DCDND +L+    +    G  CH G  SCF         L     
Sbjct: 73  GEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFS------VLKDGAW 126

Query: 121 LLAERKSADPETSY 134
              +    DPE+ Y
Sbjct: 127 QAVDPVLKDPESIY 140


>UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae
           RepID=HIS3_GLUOX
          Length = 156

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 2/124 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +    ++ ++  +GL+  + Q A  G VLML +MN +AL +TL +G+V ++SR++Q+L
Sbjct: 30  IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGETSG    ++    DCD D +L++ +  G  CH G  SCF             +  
Sbjct: 88  WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYHGVTPDGLRDTSQPE 147

Query: 122 LAER 125
           ++  
Sbjct: 148 ISAE 151


>UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales
           RepID=HIS3_RHISN
          Length = 152

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 66/129 (51%), Gaps = 4/129 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  A  GE+LM+ +MN EAL  T+E+G   ++SR++  LW KGE+SGN
Sbjct: 24  RFD-EKGLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGN 82

Query: 71  FLNVVSIAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D + +     G   TCH G  SCF  T        ++  +  E +  
Sbjct: 83  TQAVQEIRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARV-TITDEHRHF 141

Query: 129 DPETSYTAK 137
           DP   Y  K
Sbjct: 142 DPAQIYAEK 150


>UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria
           RepID=HIS3_BIFLI
          Length = 136

 Score =  155 bits (393), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 44/105 (41%), Positives = 63/105 (60%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
               GL+  ++Q   + EVLM+GYMN EAL +TL +G+VTF+SR++Q  W KG+TSG+  
Sbjct: 22  RDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEYWRKGDTSGHVQ 81

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
            V  ++ DCD D LLV  + +G  CH G  SCF +     +    
Sbjct: 82  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 126


>UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides
           RepID=Q03VY1_LEUMM
          Length = 132

 Score =  155 bits (392), Expect = 8e-37,   Method: Composition-based stats.
 Identities = 49/125 (39%), Positives = 70/125 (56%), Gaps = 2/125 (1%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M+  +   + + +  +GL+P ++  A +   LMLGYMN E+   T  +G+  F+SR +Q 
Sbjct: 1   MIGTE--PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQE 58

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGETSGN   VVS+  DCD DTLL+  NP GP CH    SCF +T          + 
Sbjct: 59  LWHKGETSGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQA 118

Query: 121 LLAER 125
            +A +
Sbjct: 119 TIANK 123


>UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii
           'Deep ecotype' RepID=B4RV64_ALTMD
          Length = 133

 Score =  155 bits (392), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 46/112 (41%), Positives = 68/112 (60%), Gaps = 1/112 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   EL+++  DGL+PVI Q   S +VLM  +M+ E+LD+TL +GK+ ++SR++Q LW 
Sbjct: 20  DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL 115
           KG +SG+   V SIA DCD D LL   + +G  CH    SCF     +    
Sbjct: 79  KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFYLRFWEDKVT 130


>UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae
           RepID=HIS3_METS3
          Length = 132

 Score =  154 bits (390), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 42/132 (31%), Positives = 67/132 (50%), Gaps = 5/132 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
             R E++ +K    +  I Q   +G++LM+  MN +AL KT+E+GK  ++S ++   W K
Sbjct: 4   NFRHEINGQKV---ITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SG+   V  I  DCD D +++     G  CH+G  SCF    +        E+ L  
Sbjct: 61  GESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLET 120

Query: 125 --RKSADPETSY 134
              K  +P+  Y
Sbjct: 121 ILEKVFNPDDVY 132


>UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms
           RepID=C7NRL7_HALUD
          Length = 138

 Score =  154 bits (390), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 49/126 (38%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +L +E  + L P + Q A SG+VLML Y+  EALD+T E+G   ++SR++  LW KGETS
Sbjct: 22  DLAFEDNEYL-PAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETS 80

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           GN  ++  I  DCD D LL +    G  CH G  SCF  T         ++  +   +  
Sbjct: 81  GNVQHLKEIRVDCDGDALLYVIEQDGGACHTGFQSCFHRT---------IDGEVVGERVF 131

Query: 129 DPETSY 134
           DP+  Y
Sbjct: 132 DPDDVY 137


>UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria
           RepID=HIS3_BACCN
          Length = 101

 Score =  153 bits (386), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 43/94 (45%), Positives = 61/94 (64%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P IV +  + EVLML YMN EA +KTL++ K  F+SR++Q LW KG TSG+  +V
Sbjct: 6   SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            S+  DCD D +++  N +G  CH G  +CF   
Sbjct: 66  KSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99


>UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium
           amycolatum SK46 RepID=UPI000185C2AA
          Length = 132

 Score =  153 bits (386), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 41/103 (39%), Positives = 59/103 (57%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                 +     DGL+P IVQ   +G VLM+ +M+  AL  T+ + + T++SR++   W 
Sbjct: 23  PADIANIAKFNADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWI 82

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           KG TSG+F  V S+A DCD DT+L+     G  CH G+ SCF 
Sbjct: 83  KGLTSGHFQTVTSLALDCDGDTVLMQVVQDGAACHTGSHSCFD 125


>UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA
          Length = 126

 Score =  152 bits (385), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 41/105 (39%), Positives = 59/105 (56%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P I Q A +G VLML +MN EA D+T+   +  +FSR++ +LW KG+TSG+   V  I
Sbjct: 21  LLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVREI 80

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
             DCD DT+L+     G  CH+   SCF          +  E+ +
Sbjct: 81  RVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERI 125


>UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria
           RepID=C7RQA3_9PROT
          Length = 142

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 40/110 (36%), Positives = 64/110 (58%), Gaps = 1/110 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +   EL +++  GL+  I Q   + E+LML +MN  A+++TL +G   ++SR+++ +W K
Sbjct: 18  EVLDELAFDQ-QGLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           GETSG    V+    DCD D +L+L + +G  CH G SSCF +       
Sbjct: 77  GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRNGRV 126


>UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13
           RepID=B6BVA2_9PROT
          Length = 129

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 51/131 (38%), Positives = 76/131 (58%), Gaps = 6/131 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               ++ W    GL+P I+Q   S +V+M+ +MN EAL KT+E+ +  F+SR++ ++W K
Sbjct: 2   NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE SGNF NVVSI  DCD D+LLV  N   G +CH G +SCF +          + + + 
Sbjct: 61  GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120

Query: 124 ERKSADPETSY 134
           +    DP+  Y
Sbjct: 121 K----DPKLIY 127


>UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI
          Length = 161

 Score =  152 bits (384), Expect = 7e-36,   Method: Composition-based stats.
 Identities = 47/133 (35%), Positives = 68/133 (51%), Gaps = 8/133 (6%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+PV+   A +GEVLM  YMN EAL KT+E+G+  ++SR++Q+LW KG++SG 
Sbjct: 23  KFD-CNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWHKGQSSGL 81

Query: 71  FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQ-----WLFLYQLEQLLA 123
              V  +A D D D L +       G +CH G  SCF                       
Sbjct: 82  VQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEPIQLTFTE 141

Query: 124 ERKSADPETSYTA 136
             K+ DP+T Y  
Sbjct: 142 TEKTFDPKTVYGN 154


>UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41B27
          Length = 137

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 9/136 (6%)

Query: 9   ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           EL++    G   L+  + Q   + +VLM+ +MN EA+++TL++ K  ++S ++Q+ W KG
Sbjct: 2   ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL---- 121
           E+SGN   V  +  DCD D +++  + IG  CH+G  SCF            L+ L    
Sbjct: 62  ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDED 121

Query: 122 --LAERKSADPETSYT 135
             +   +  DP+  Y 
Sbjct: 122 ISIISERLFDPKEMYG 137


>UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RPU9_FIBSS
          Length = 116

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 51/116 (43%), Positives = 68/116 (58%), Gaps = 5/116 (4%)

Query: 1   MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57
           M  E   +E+ +E   G   L P IVQ A  G+VLM+ +MN EAL +T E G++ F+SR+
Sbjct: 1   MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60

Query: 58  KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111
           ++  W KG+TSGN + VV  A DCD+D LL      GP   CH G  SCF  T  +
Sbjct: 61  RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116


>UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_MESSB
          Length = 139

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 44/100 (44%), Positives = 61/100 (61%), Gaps = 3/100 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+  +V  A  G +LM+ +MN EAL KTLE+G   ++SR++  LW KGETSGN
Sbjct: 27  RFD-ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGN 85

Query: 71  FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDT 108
             +V SI+ DCD D +L+       G TCH G  SCF   
Sbjct: 86  LQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRN 125


>UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae
           RepID=HIS3_PYRCJ
          Length = 128

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 38/101 (37%), Positives = 60/101 (59%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
           + L++    G +  +VQ   +GEVLM+G+M+P A+  TL +G   ++S +++R+W KGET
Sbjct: 17  KSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKGET 76

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           SG++  V     DCD D +++    IG  CH G  SCF   
Sbjct: 77  SGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSP 117


>UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter
           necessarius RepID=B1XSV4_POLNS
          Length = 140

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 2/103 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W    GL+PVI Q   S ++LM+ +MN +AL +TL  G+  +++R++Q+LW K
Sbjct: 21  SWLDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHK 79

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106
           GE SG+   V  I  DCD DT+L+L     G  CH G  SCF 
Sbjct: 80  GEESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122


>UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G191_ABIDE
          Length = 295

 Score =  149 bits (376), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 49/113 (43%), Positives = 66/113 (58%), Gaps = 1/113 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+P IVQ   +G VL + YMN E+L+ TL      F+SR+++ LW KGE
Sbjct: 18  IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           TSGN+ +VVSI  DCD D LLV     G  CH+G  SCF DT         +E
Sbjct: 77  TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDTMKIEFEENIME 129


>UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales
           RepID=HIS3_MYCBP
          Length = 115

 Score =  148 bits (375), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 41/107 (38%), Positives = 63/107 (58%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +         DGL+  +VQ   SG+VLM+ +MN EAL +TL++ + T++SR++  
Sbjct: 1   MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD 107
            W KG TSG+  +V S+  DCD D +L+  + +G  CH G  SCF  
Sbjct: 61  QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFDA 107


>UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/
           phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus
           Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT
          Length = 127

 Score =  148 bits (375), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 44/130 (33%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           Q   +L +    GL+P ++  A  G+ L L YMN +A+ KT+E+GK+  F R++ RL  K
Sbjct: 2   QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GETSG+  +V  I  DC+ ++L+ +       CH G  SC+                + E
Sbjct: 61  GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQTNSI----QVVE 116

Query: 125 RKSADPETSY 134
            K  DPE  Y
Sbjct: 117 EKVFDPENVY 126


>UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1
           RepID=A3WCC9_9SPHN
          Length = 143

 Score =  148 bits (375), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 47/98 (47%), Positives = 65/98 (66%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  + + EVL++ +MN +AL KT E+GKV F+SR++  LW KGETSGN
Sbjct: 32  KFD-ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGN 90

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L+V  I  DCD D L++ A P GPTCH G +SCF   
Sbjct: 91  VLSVDEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128


>UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales
           RepID=HIS3_ERYLH
          Length = 125

 Score =  147 bits (372), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 45/98 (45%), Positives = 63/98 (64%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++ +DGL+  +VQH  + EVLM+ +MN +ALD T ++G   FFSR++Q LW KG TSGN
Sbjct: 18  KFD-SDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGN 76

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L V  +  DCD D +++L  P GP CH G  +CF   
Sbjct: 77  TLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE 114


>UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P0M4_9BACE
          Length = 108

 Score =  147 bits (371), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 50/97 (51%), Positives = 71/97 (73%), Gaps = 1/97 (1%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           ++K++ L+PVI+Q A + EVLMLG+ N EA++ TL++    F+SR++Q+LW KGETSG+F
Sbjct: 8   FQKSE-LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHF 66

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           L+V  +  DCD DTLL   +P+GPTCH G  SCF   
Sbjct: 67  LHVERMVTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103


>UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ
          Length = 149

 Score =  146 bits (369), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 50/133 (37%), Positives = 68/133 (51%), Gaps = 19/133 (14%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+P IV  A SG VLM  +MN +AL +T+ +G   F+SR++ +LW KGE SGN L+V
Sbjct: 29  SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88

Query: 75  VSIAPDCDNDT--LLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
             +  DCD D   LL      G  CH G  SCF                   R  A P++
Sbjct: 89  KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR-----------------RLIASPDS 131

Query: 133 SYTAKLYASGTKR 145
           S +  L ++G   
Sbjct: 132 SGSLSLESAGLPL 144


>UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae
           RepID=HIS3_ZYMMO
          Length = 124

 Score =  145 bits (365), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 36/102 (35%), Positives = 61/102 (59%), Gaps = 1/102 (0%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           W+   GL+  ++  A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ 
Sbjct: 15  WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           + +  I  DCD DTL +   P+GP CH G  SCF        
Sbjct: 74  MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVEDGH 115


>UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris
           BL2 RepID=B8EQR3_METSB
          Length = 141

 Score =  144 bits (364), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 42/106 (39%), Positives = 57/106 (53%), Gaps = 2/106 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+  + + A  GE+LM+ YMN EAL  TL +G+  ++SR++Q +W KG TSG    V
Sbjct: 30  PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89

Query: 75  VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
             I  DCD D LL  + A   G  CH G  SCF     +      +
Sbjct: 90  REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYRRLSETGDGETV 135


>UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum
           ATCC BAA-798 RepID=D1CF76_THET1
          Length = 300

 Score =  141 bits (355), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 48/132 (36%), Positives = 76/132 (57%), Gaps = 8/132 (6%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W K
Sbjct: 9   NLVDMLQYD-EHGLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLK 67

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GETSG  L+V  + P+C+ ++LL+L +   P  CH G  SCF         +        
Sbjct: 68  GETSGRTLHVRELRPNCELNSLLILVDQRLPGACHTGHFSCFYRRLEDGELVE------I 121

Query: 124 ERKSADPETSYT 135
           E    DPE  Y+
Sbjct: 122 EPPLFDPEDVYS 133


>UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001744401
          Length = 141

 Score =  139 bits (351), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 2/115 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  DGL+P I     + E LM+ YMN E L  T+  G+  ++SR+++ +W KG+TSG 
Sbjct: 28  KFD-ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGE 86

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           F  V  I  DCD D +++    +G   CH    +CF               L+  
Sbjct: 87  FQVVKEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRKVDLENVTAGPVPLVRA 141


>UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales
           RepID=HIS3_METVS
          Length = 136

 Score =  135 bits (341), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 37/105 (35%), Positives = 56/105 (53%), Gaps = 3/105 (2%)

Query: 6   QRRELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           Q  +L + K D   L+  I        VLM  +M+ E+L  TL++G + +FS ++ ++W 
Sbjct: 17  QNMDLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWM 75

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           KGE S N   V+ +  DCD D LL +    G  CH+G  SCF + 
Sbjct: 76  KGEESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNK 120


>UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HIS3_IGNH4
          Length = 129

 Score =  134 bits (337), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 36/106 (33%), Positives = 59/106 (55%), Gaps = 1/106 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             ++    L++   D  +  + Q   SG+VLM+  MN EA+ KTL +G V ++S++++ L
Sbjct: 8   EAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKEL 67

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFG 106
           W KG TSG+   +     DCD D++L++        CH+G  SCF 
Sbjct: 68  WVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFH 113


>UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC
           23134 RepID=A1ZDC3_9SPHI
          Length = 130

 Score =  131 bits (331), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 47/116 (40%), Positives = 66/116 (56%), Gaps = 7/116 (6%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           +EK  GL+PV+VQ   SG+VLMLGY N  AL +TL++G  TF+S ++  LWTKG+TSG++
Sbjct: 15  FEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGDY 74

Query: 72  LNVVSIAPDCDNDTLLVLANPIGP-TCHK------GTSSCFGDTAHQWLFLYQLEQ 120
           L +  I  DCD D L+     +G   CH          SCF         L  +++
Sbjct: 75  LKITHILTDCDQDALVYQVTMMGAGACHTKDENNQARVSCFYRKMASGKTLEFIDK 130


>UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58
           RepID=Q1NG03_9SPHN
          Length = 157

 Score =  130 bits (328), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 45/128 (35%), Positives = 67/128 (52%), Gaps = 5/128 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GLMP IV +A    VLMLGYMN EAL +TL + +  F+SR+++ LW KGE SG 
Sbjct: 22  RFD-AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGF 80

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQL---EQLLAERK 126
              V  +  D D D L+++     P +CH G  SCF       +   +     + +    
Sbjct: 81  RQRVDHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDKSPVRLRRIEREA 140

Query: 127 SADPETSY 134
           + D +T Y
Sbjct: 141 AFDAKTVY 148


>UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI0001910D6A
          Length = 157

 Score =  129 bits (325), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 74/81 (91%), Positives = 77/81 (95%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR
Sbjct: 77  MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136

Query: 61  LWTKGETSGNFLNVVSIAPDC 81
           LWTKGETSG+ LNVVSIAPDC
Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157


>UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira
           RepID=HIS3_LEPIN
          Length = 187

 Score =  127 bits (320), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 13/133 (9%)

Query: 9   ELDWEKT--------DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
            LD++KT          L+PV+      G++LM  + N E+   +L++G   +FSR++ +
Sbjct: 60  PLDFQKTTELLLTGKKNLVPVVAIDLQ-GQILMQAFGNEESQTLSLKTGYAHYFSRSRNQ 118

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG+TSG+   ++ I    D   L+         CH+G  SCF     +        +
Sbjct: 119 LWKKGDTSGHTQKILQILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERME----GVTWK 174

Query: 121 LLAERKSADPETS 133
           LL   ++  PE S
Sbjct: 175 LLPVPRNFLPEKS 187


>UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae
           RepID=HIS3_SULSO
          Length = 85

 Score =  124 bits (313), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 35/79 (44%), Positives = 49/79 (62%)

Query: 33  MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92
           M+G MN EAL KTL +G + F+S ++++LW KGETSGNF  +     DCD D +L     
Sbjct: 1   MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60

Query: 93  IGPTCHKGTSSCFGDTAHQ 111
           +GP CH G  +CF  +  +
Sbjct: 61  LGPICHTGNYTCFYRSYDE 79


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  123 bits (310), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 39/137 (28%), Positives = 66/137 (48%), Gaps = 14/137 (10%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            ++ ++ DCDND +  +    G  CH     CFG+       + +LE+ L  RK + PE 
Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNL----TGIARLEKTLKARKESAPEG 221

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA+L+ +  K +  K+ EE  E   A     + ++  EA+DL+Y  L      G+ + 
Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDA---KTKEDVAFEAADLIYFALTKAVSAGVSVA 277

Query: 193 TVIENLR------KRHQ 203
            + ++L       KR +
Sbjct: 278 DIEKSLDAKGWKVKRRK 294


>UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa
           serovar Patoc RepID=B0SHA6_LEPBA
          Length = 202

 Score =  119 bits (298), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 1/108 (0%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           +    L P + Q  ++G+ LML +   E+L   +ESG  T+FSR++   W KGE SG+F 
Sbjct: 89  DSMPPLSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQ 147

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
            +  I    +   +  + + IG  CH G  SCF     Q   +  +  
Sbjct: 148 KLKQIYVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYS 195


>UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7
           genomosp. GTL1 RepID=A5KSK8_9BACT
          Length = 125

 Score =  117 bits (294), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 47/103 (45%), Positives = 59/103 (57%), Gaps = 7/103 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +D +  + L+   V       V       M GYMN  A++ TL  G VTFFSRT  +LW 
Sbjct: 20  VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79

Query: 64  KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           KGETSGN L +   I  DCD D+LL+ A P+G TCH G+ SCF
Sbjct: 80  KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCF 122


>UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD
          Length = 101

 Score =  116 bits (291), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+PV+V    SG++LML Y +   L+ T  +G   ++SR++Q +W KG +SG    V ++
Sbjct: 7   LLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQLVQAV 66

Query: 78  APDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAH 110
             DCD D L   VL    G  CH    SCF     
Sbjct: 67  YRDCDGDALNFRVLVLGDGRVCHTRQVSCFHTRLW 101


>UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms
           RepID=HIS2_PELTS
          Length = 98

 Score =  116 bits (290), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 34/95 (35%), Positives = 50/95 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
             +   +  L +++ +R+   P+ SYTA L+  G  +I +K+GEE  E  +AA       
Sbjct: 1   MGEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAA 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E +DL+YHLLVLL   GL    V+  L  R Q
Sbjct: 61  LVGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95


>UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria
           RepID=HIS2_CLOB1
          Length = 110

 Score =  115 bits (288), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 32/95 (33%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            ++   +  L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   D  E
Sbjct: 1   MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  DL YH++VL+ ++ + L  + + L KR +
Sbjct: 61  LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95


>UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=A6LT24_CLOB8
          Length = 108

 Score =  113 bits (282), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 48/90 (53%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L + + +RK+   E SYT  L+  GT +I +KVGEE  E  ++   +++ E  NE
Sbjct: 3   ENIKALYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             DL YHLLVL+    + +  V   L KR 
Sbjct: 63  ICDLTYHLLVLMAQMNISIEEVGAELEKRR 92


>UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria
           RepID=HIS2_LEPBJ
          Length = 92

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 48/91 (52%), Positives = 61/91 (67%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             FL QLE +L +RK   P+ SYTA L+  G  RI +KVGEE  E  +AA   D+ ELT+
Sbjct: 1   MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+DL++HL VLL +Q L L  V+E LRKRH
Sbjct: 61  EAADLLFHLQVLLVEQELSLQDVVEELRKRH 91


>UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium
           RepID=HIS2_CLONN
          Length = 110

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/95 (30%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 + +L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   ++ +
Sbjct: 1   MDNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDD 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  D++YH++VL+ ++ + L  +   L KR +
Sbjct: 61  LIAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95


>UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes
           RepID=HIS2_BACC2
          Length = 107

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 28/90 (31%), Positives = 49/90 (54%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                L + + ERK +    SYT  L++ G  +I +K+GEE  E  +A   +D+ E+  E
Sbjct: 3   NAFKLLYKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             D+ YH  VLL ++ + L  V+  +++R+
Sbjct: 63  MVDVFYHCFVLLAEKNIALEDVMREVKERN 92


>UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5
          Length = 105

 Score =  111 bits (278), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 51/90 (56%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L  ++ +RK    + SYT  L+  G  +I +KVGEE  E  +A+   ++ +   E 
Sbjct: 1   MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            DL+YH+LVL+ ++ + L  + + L KR Q
Sbjct: 61  CDLIYHVLVLMANENITLEELRKELEKRRQ 90


>UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria
           RepID=HIS2_MAGSA
          Length = 109

 Score =  110 bits (276), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 42/92 (45%), Positives = 56/92 (60%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +L  ++A RK  DP+ SYTAKL+A G  +IAQK GEE VET +AA    + EL
Sbjct: 3   QDSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDEL 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++D +YHLLVL  D G++   V   L +R
Sbjct: 63  VGESADTLYHLLVLWADCGVEPAKVWAELARR 94


>UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales
           RepID=HIS2_BORA1
          Length = 116

 Score =  110 bits (275), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 28/74 (37%), Positives = 38/74 (51%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP+TSY AKL A G     +K+GEE  E  +AA       + +E +DL +H LV L    
Sbjct: 29  DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88

Query: 189 LDLTTVIENLRKRH 202
           L    V+  L +R 
Sbjct: 89  LRPEDVLAELARRE 102


>UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum
           ATCC 11170 RepID=HIS2_RHORT
          Length = 117

 Score =  109 bits (274), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 36/89 (40%), Positives = 52/89 (58%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L  ++A R+ ADP TSYTAKL+  G  +I QK GEE  E  +AA V    ++  E
Sbjct: 15  EIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAE 74

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           ++D++YHL+VL  D G+    V   L +R
Sbjct: 75  SADVLYHLMVLWADVGVTPDRVWAELARR 103


>UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria
           RepID=HIS2_NITMU
          Length = 121

 Score =  109 bits (273), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 34/94 (36%), Positives = 49/94 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 L++L + +  RK +DP  SY AKL   G  +I +K+ EE  E  LA+   D   
Sbjct: 1   MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  E +DL +H LVLL    L L  V++ LR+R 
Sbjct: 61  VVRETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94


>UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria
           RepID=HIS2_NEIG1
          Length = 107

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 32/93 (34%), Positives = 48/93 (51%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  ++Q + +RKSADP  SY A+L   G  +I +KV EE  E  +A+   D   L
Sbjct: 1   MGDSVLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             E +DL +H ++LL    L    V++ L +R 
Sbjct: 61  VYEVADLWFHTMILLTHHDLKAEDVLDELSRRQ 93


>UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei
           group RepID=HIS2_LACCB
          Length = 110

 Score =  108 bits (270), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 29/94 (30%), Positives = 45/94 (47%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 +  L   + ER++     SYT  L+  G  +I +KVGEE  E  +AA   D   
Sbjct: 2   TQAKQSIPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPA 61

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
              E +DL YH+LVL+ ++G+ +  +   L  R 
Sbjct: 62  FILEVADLTYHVLVLMVERGITVDQIATELASRE 95


>UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria
           RepID=HIS2_GRABC
          Length = 160

 Score =  108 bits (270), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 35/96 (36%), Positives = 56/96 (58%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           D  +    L +L +++ +R+ ADP  S++A+L + G  ++AQK GEE VE  + A   D+
Sbjct: 38  DPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLVL    G++   V   L KR 
Sbjct: 98  EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133


>UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KWI3_HALNC
          Length = 124

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 44/95 (46%), Positives = 60/95 (63%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
            T +    L QL  ++ +RK ADP +SY A+L+A G  +IAQKVGEEGVE ALAA   D 
Sbjct: 2   ATNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDN 61

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             + +E +DL +H +VLL D GL    V++ L +R
Sbjct: 62  VAIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96


>UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms
           RepID=HIS2_ALHEH
          Length = 109

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/91 (39%), Positives = 50/91 (54%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           Q   L  L ++L ER+ ADP TSY AKL+  G   I +KVGEE  E  +AA   DR ++ 
Sbjct: 4   QRDILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVI 63

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +DL +H L++L         V+  L +R
Sbjct: 64  YETADLWFHSLIMLSACDAGPDDVLAELERR 94


>UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZNB1_9GAMM
          Length = 125

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 31/82 (37%), Positives = 50/82 (60%)

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           +++ +R+ ADPE SY AKL+A G   + +K+GEE  ET +A    D   L +E +DL +H
Sbjct: 20  EVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKNDDSDALVSEMADLWFH 79

Query: 180 LLVLLQDQGLDLTTVIENLRKR 201
            L++L  +G     V++ L +R
Sbjct: 80  SLIVLAARGRHPDDVLDELARR 101


>UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales
           RepID=B0MMD1_9FIRM
          Length = 114

 Score =  107 bits (268), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 37/99 (37%), Positives = 58/99 (58%), Gaps = 5/99 (5%)

Query: 110 HQWLFLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
            +     ++ +++  RK+       PE SYT  L+  G  +I +KVGEE  ET +AA   
Sbjct: 1   MKMTVYEEIFEVIKARKAQYDAGNAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNA 60

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           D  EL NE +DL+YH++VL  D+GL+ + V E L +R++
Sbjct: 61  DNDELKNEINDLLYHVMVLCADRGLEWSEVEEVLSERNE 99


>UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=A4EBZ9_9ACTN
          Length = 105

 Score =  106 bits (264), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 31/103 (30%), Positives = 49/103 (47%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G  +      +    L  L +++  R+ A P+ SYTA+L       + +K+ EE  E  +
Sbjct: 2   GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61

Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A   +D   +  EA DL+YHLLV L+  G+ L  +   L  R 
Sbjct: 62  ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARR 104


>UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales
           RepID=HIS2_LEUMM
          Length = 114

 Score =  106 bits (264), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 1/92 (1%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +   ERK      SYT  LY  G  +I +KVGEE  E  L A  ++  EL
Sbjct: 1   MPQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EEL 59

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E SDL++HL+VLL ++G+ L  + + L  R
Sbjct: 60  IYETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91


>UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=HIS2_UNCMA
          Length = 95

 Score =  106 bits (264), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 2/93 (2%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELT 170
             L ++  ++A+RK    E SYT  LY    G  ++ +K+GEE  E  +AA      E+ 
Sbjct: 3   DVLDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIV 62

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +E +DL +H +VLL  + +    + E   +R +
Sbjct: 63  SECADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95


>UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria
           RepID=HIS2_MAGSM
          Length = 252

 Score =  106 bits (264), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 39/99 (39%), Positives = 52/99 (52%), Gaps = 2/99 (2%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
                     L Q+ Q++ +RKSA DPE SY AKL+  G   I +KVGEE  E  LA   
Sbjct: 3   NLSPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKG 62

Query: 164 H-DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              R E+ +EA+DL++H LV L    +  T V+  L  R
Sbjct: 63  RAARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101


>UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria
           RepID=HIS2_ACIAC
          Length = 137

 Score =  105 bits (263), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 33/112 (29%), Positives = 47/112 (41%), Gaps = 7/112 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSA---DPETSYTAKLYASGTKRIAQKVGEEG 154
           H   S       H    L +L  ++  RK A   D + SY A+L   G     +K+GEE 
Sbjct: 3   HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62

Query: 155 VETALAATVHDRFE----LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            E  +AA   D       L  E +DL +H ++ L   GL    V+  L +R 
Sbjct: 63  TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114


>UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria
           RepID=HIS2_HALHL
          Length = 114

 Score =  105 bits (262), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 31/97 (31%), Positives = 50/97 (51%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                     L  L + + +R+ A  +TSY A+L+  G   I +KVGEE  E  +AA   
Sbjct: 4   AASERTAADTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGG 63

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +R ++  E +DL +H LV+L   G+ +  V+  L +R
Sbjct: 64  EREQVVYETADLWFHTLVMLSASGVSVDEVLAELERR 100


>UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria
           RepID=HIS2_ACICJ
          Length = 133

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 34/96 (35%), Positives = 53/96 (55%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
             A     L +L   +  RK+ADP  S++A+L + G  ++AQK GEE VE  + A   +R
Sbjct: 14  PAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGEESVECLIEAVAGNR 73

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLV+    G+    V   L++R 
Sbjct: 74  TALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109


>UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1
           Tax=Raoultella terrigena RepID=Q6U8A9_KLETE
          Length = 88

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 71/83 (85%), Positives = 75/83 (90%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           LLAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL
Sbjct: 6   LLAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHL 65

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +VLLQDQ L L  +I NL+ RHQ
Sbjct: 66  MVLLQDQELSLQDIIANLKSRHQ 88


>UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM
           10642 RepID=C8SBH0_FERPL
          Length = 92

 Score =  104 bits (261), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
            L +L++++ ERK      SYTAKL     G  ++ +K GEE VE  LA    D+  +  
Sbjct: 1   MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EA+DL+YH +VLL    + +  V + LR+R +
Sbjct: 61  EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92


>UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BVA1_9PROT
          Length = 104

 Score =  104 bits (261), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 36/90 (40%), Positives = 59/90 (65%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
              L +L+QL+  +K +DP  SYTAKL++ G + I +K GEE +E  +A+   ++  + N
Sbjct: 1   MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           E++D++YHLLVLL ++ + L  VI  L +R
Sbjct: 61  ESADVLYHLLVLLSEKSVTLKEVISELERR 90


>UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis
           RepID=HIS2_ZYMMO
          Length = 107

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 43/93 (46%), Positives = 57/93 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  +E ++AER+ A PE SY + L+  GT  IAQKVGEE VET +AA   D+  L
Sbjct: 1   MSEETLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +EA+DL++HL VLL D+G     V   LR+R 
Sbjct: 61  ESEAADLIFHLAVLLADRGSSFENVFSELRRRE 93


>UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei
           RepID=HIS2_IGNH4
          Length = 102

 Score =  104 bits (259), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/91 (37%), Positives = 54/91 (59%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
            FL +L  ++ +R    P+ SYTA++   G    A+K GEE VE  +A+    R  +  E
Sbjct: 3   DFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D++YHL+VLL  +G+D   VI+ L +R +
Sbjct: 63  AADVIYHLMVLLALRGVDWAEVIKELERRSR 93


>UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria
           RepID=HIS2_BURCC
          Length = 121

 Score =  104 bits (259), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 4/99 (4%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV---- 163
           T      L +L  ++  RK  DP+ SY ++L+  G   + +K+GEE  E  LAA      
Sbjct: 2   TQSTEDTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQG 61

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                L  E +DL +H LV+L    L    VI  L +R 
Sbjct: 62  GAPTALVGEVADLWFHCLVMLSHFDLSPADVIAELERRE 100


>UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ
          Length = 127

 Score =  103 bits (257), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 37/96 (38%), Positives = 53/96 (55%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
            +       L +L  L+  R+S   + SYTA+L  +G +R A+K GEE VET +AA   D
Sbjct: 15  KEFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETVIAALGSD 74

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              L  EA+D +YHLLVLL+ + +    V+  L  R
Sbjct: 75  ASALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110


>UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SM22_9BACT
          Length = 100

 Score =  103 bits (256), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 28/92 (30%), Positives = 51/92 (55%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +++ ERK+   + SYT +L   G+ +I +K+GEE  E   A    D  ++
Sbjct: 1   MNVEIIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E +DL+YHL+V L+ + +    V+  L++R
Sbjct: 61  AGETADLLYHLIVALEFRNVQFEDVLGVLQER 92


>UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae
           RepID=HIS2_METBF
          Length = 104

 Score =  102 bits (254), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 51/90 (56%), Gaps = 2/90 (2%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            ++ +++ +RK    E SY  KL     G  +I +KVGEE +ET LA    +  E+ +E+
Sbjct: 10  NRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNENHEEIVSES 69

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           SDL++HLLV+L    + L  +   L  RH+
Sbjct: 70  SDLIFHLLVMLAANNVTLDEIAAELSARHE 99


>UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales
           RepID=HIS2_METB6
          Length = 104

 Score =  102 bits (254), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGV 155
           H+G              + +L  ++ ER     E SYT++L     G  ++ +KVGEE  
Sbjct: 3   HEGKEPV------DLRVIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEEST 56

Query: 156 ETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           E  LA         T EA+DL +H+LV L+   +DL+ VI  L +R +
Sbjct: 57  EFILAVKNGVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104


>UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria
           RepID=HIS2_NITWN
          Length = 116

 Score =  101 bits (253), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 36/96 (37%), Positives = 51/96 (53%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
                Q   ++ L  ++  R ++  + SYT KL   G    A+K+GEE VET +AA   D
Sbjct: 6   SRRIMQRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKD 65

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           R  L  E +DLM+H LVLL+  G+ L  V   L +R
Sbjct: 66  RHHLIAEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101


>UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae
           RepID=HIS22_BRAJA
          Length = 134

 Score = 99.5 bits (247), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 46/90 (51%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L   +   +  DP TS TA+L+  G  ++A+K+ EE +E  + A   D   +  E
Sbjct: 3   DSLERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++DL+Y+L VL    G+    V   + +R 
Sbjct: 63  SADLLYNLTVLWASAGVRPEDVWREMTRRE 92


>UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TJZ9_9PROT
          Length = 104

 Score = 99.2 bits (246), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 50/91 (54%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             + +L + +   ++  P  S TA+L   G  +IA+KV EE  E AL A V DR  +  E
Sbjct: 3   HPIDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           ++DL+Y+L+VL    G+  + V   + +R +
Sbjct: 63  SADLLYNLMVLWVWMGITPSEVWAEMEQREK 93


>UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum
           hungatei JF-1 RepID=Q2FUB9_METHJ
          Length = 91

 Score = 98.8 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 50/90 (55%), Gaps = 2/90 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + ++  ++ ER +   E SYT+K+     G  +  +K+GEE  E  +A    D+  ++ E
Sbjct: 1   MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL++H ++ L+  G+ L +V + L+ R 
Sbjct: 61  GADLLFHFMLALKRSGVTLQSVWDELQSRR 90


>UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing
           symbionts RepID=HIS2_VESOH
          Length = 105

 Score = 98.8 bits (245), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 30/85 (35%), Positives = 48/85 (56%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +LEQ+L +RKSA  + SY + LY  GT  I +K+ EE  E  +A       ++  E +DL
Sbjct: 7   KLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEIADL 66

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
            +H LVLL+ + + +  +   L +R
Sbjct: 67  WFHTLVLLRFKKIKVEQITNELSRR 91


>UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria
           RepID=HIS2_BRUA1
          Length = 107

 Score = 98.4 bits (244), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  LE+++AER S    TSYTA L A G  + AQK+GEE VET +AA   DR  +
Sbjct: 1   MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +E++DL+YHL V+    G+ L  V++ L++R
Sbjct: 61  VSESADLLYHLAVVWNIAGVALEDVLQELQRR 92


>UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales
           RepID=HIS2_MESSB
          Length = 112

 Score = 98.4 bits (244), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 36/92 (39%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE ++AER ++    S+TA+L ++G  + A+K+GEE VET +AA   D+  L
Sbjct: 1   MNEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKAL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++DL+YH LV+L+  G+ L  V+  L  R
Sbjct: 61  IAESADLVYHWLVVLKIAGVRLDEVMLELESR 92


>UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae
           RepID=Q2CDY7_9RHOB
          Length = 106

 Score = 97.2 bits (241), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 34/82 (41%), Positives = 50/82 (60%), Gaps = 1/82 (1%)

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + +A RK ADP+ S+TA+L AS  +  A+K GEE VE  + A   DR  L +EA+D++YH
Sbjct: 8   ETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSEAADVIYH 66

Query: 180 LLVLLQDQGLDLTTVIENLRKR 201
           LLV+     + L  +   L +R
Sbjct: 67  LLVMCAVNDITLADIERELERR 88


>UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis
           HTCC2503 RepID=A3VQS9_9PROT
          Length = 109

 Score = 97.2 bits (241), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 38/89 (42%), Positives = 48/89 (53%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L   +  RK AD   SYTA L   G  R A+K GEE VE ALA  +  R +L  E 
Sbjct: 7   TLERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAET 66

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +D++YHL VLL    LD + +   L KR 
Sbjct: 67  ADVLYHLAVLLAANELDWSDISAALTKRE 95


>UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae
           RepID=HIS2_NATPD
          Length = 101

 Score = 96.9 bits (240), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 38/98 (38%), Positives = 55/98 (56%), Gaps = 2/98 (2%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVH 164
           D       L +L +++  RK   P+ SYTA L+    G   + +K+GEE  E  LAA   
Sbjct: 4   DGHDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDD 63

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           D  EL +EA+D++YHLLVLL  + ++L  +   LRKR 
Sbjct: 64  DDEELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101


>UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae
           RepID=A4SV22_POLSQ
          Length = 133

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%)

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV--------HDRFELTNEASDLMY 178
           SADP+TSYTA L++ G   I +K+GEE  E  +AA            +  L  E +DL +
Sbjct: 33  SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L+ L    L    VI  L +R
Sbjct: 93  HCLIALSQFNLRPEDVIAELDRR 115


>UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota
           RepID=HIS2_META3
          Length = 96

 Score = 94.9 bits (235), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 4/96 (4%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRF 167
              L +  +++ +R    PE SY A L  +       +I +KVGEE  ET LAA   D+ 
Sbjct: 1   MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ 60

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EL  E++DL++H+LVLL + G++   ++E   +R +
Sbjct: 61  ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK 96


>UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp.
          HTCC2601 RepID=Q0FX88_9RHOB
          Length = 164

 Score = 93.4 bits (231), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 30/65 (46%), Positives = 39/65 (60%)

Query: 15 TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           DGLMP     A SGE+LMLG+M  EA   T+E+G+  +FSR +Q LW +G  SG  L +
Sbjct: 12 PDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKL 71

Query: 75 VSIAP 79
          V    
Sbjct: 72 VEARI 76


>UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis
           RepID=HIS2_SPHAL
          Length = 109

 Score = 93.0 bits (230), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 39/91 (42%), Positives = 54/91 (59%), Gaps = 1/91 (1%)

Query: 113 LFLYQLEQLLAERKSADP-ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             L +LE ++ +R +A   E SY A L A G  +IAQK+GEE VE  +AA   D   L  
Sbjct: 7   ETLGRLEAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIG 66

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EASDL++HL +LL ++GL    +   L +RH
Sbjct: 67  EASDLVFHLSILLAERGLTWDAIAAELDRRH 97


>UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K
           RepID=B4UDK1_ANASK
          Length = 110

 Score = 92.2 bits (228), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 6/90 (6%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNE 172
              + + R  A P  SYT KL A+   RI +K+ EE  E   A          +  L +E
Sbjct: 11  WATIESRRADAAPAESYTKKLLAA-PARIRRKIIEEAYEVNEAHQALLDGKDTKDHLAHE 69

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A+DL+YHL VLL    +  T V   L +RH
Sbjct: 70  AADLLYHLYVLLASADVTPTEVYGVLERRH 99


>UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB
          Length = 101

 Score = 90.7 bits (224), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
            L   + +RK+ D + SYT+ L + G  +   K+ EE  E   A   +D+  + +EA+D 
Sbjct: 7   NLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHEAADT 64

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +YH+LV L+   +    V++ L  R +
Sbjct: 65  IYHILVTLEAADIKFEDVLKELEGRKK 91


>UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae
           RepID=Q0C645_HYPNA
          Length = 120

 Score = 89.5 bits (221), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 31/104 (29%), Positives = 45/104 (43%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
              +             +  E + A     D  +S+TAKL A G    A KV EEG E A
Sbjct: 2   TAKAPLASPDRLAAALAHLAETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELA 61

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            A        + +EA+D++YH+ V L+ +G+ L  V   L  R 
Sbjct: 62  DAVRRESDDRVASEAADVIYHVFVALRSRGVALDAVAGALEARQ 105


>UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces
           RepID=HIS2_STRCO
          Length = 90

 Score = 88.8 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 26/76 (34%), Positives = 39/76 (51%)

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +  + DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V
Sbjct: 15  HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74

Query: 183 LLQDQGLDLTTVIENL 198
           ++  +G+ L  V  +L
Sbjct: 75  MMVARGISLDDVYAHL 90


>UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales
           RepID=HIS2_STRGG
          Length = 90

 Score = 88.4 bits (218), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 26/75 (34%), Positives = 38/75 (50%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +    DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V+
Sbjct: 16  KAAEGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVM 75

Query: 184 LQDQGLDLTTVIENL 198
           +  +G+ L  V  +L
Sbjct: 76  MVARGISLDDVYAHL 90


>UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani
           RepID=HIS2_CLOTE
          Length = 107

 Score = 86.8 bits (214), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
            +   L +    + + +  D   SY   L+   + +I +K+GE+  E  +A     + E 
Sbjct: 1   MEVNKLIEELVEVIKDRKNDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQ 57

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +E SDL+Y+L+VL+  Q +++  VIE L KR 
Sbjct: 58  VHEISDLIYNLMVLMMKQNIEIENVIEELGKRR 90


>UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria
           RepID=Q4JVP0_CORJK
          Length = 332

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 27/91 (29%), Positives = 38/91 (41%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
              +      L   L+ R    PE S T K   +G     +K+ EE  E  LAA      
Sbjct: 242 NEQELKTFDSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDE 301

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           EL  E S L+Y L V++  +GL    + + L
Sbjct: 302 ELAEEISQLLYWLQVVMVGRGLTPADIYKYL 332


>UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RQ70_FIBSS
          Length = 86

 Score = 84.1 bits (207), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           +   ++  L  +RK   PE   T +L+  G   I +K+ EE  E+ +AA    R     E
Sbjct: 1   MTFEEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S ++Y++ V++ ++GL L  V   L
Sbjct: 61  LSQVLYYVAVMMAEKGLTLEEVYAKL 86


>UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium
           HIMB114 RepID=D0RQN9_9RICK
          Length = 103

 Score = 83.8 bits (206), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
           +  L  L + + ERK++    SYT KL  +      +KV EE  E   A   +++    +
Sbjct: 2   FEVLEGLIKTIRERKNSSEHESYTKKLLDN-NSLCREKVMEEIKELVEAL--NEKKNEVH 58

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+D+MYH+LVLL+   + +  V+  L+KR 
Sbjct: 59  EAADVMYHILVLLEANNVKVEDVMNELKKRE 89


>UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD
          Length = 253

 Score = 82.2 bits (202), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 30/80 (37%), Positives = 50/80 (62%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ + +S +   S+T K+ A G  +I +KVGEE VE  LA    D   + +EA+D++YH+
Sbjct: 56  IITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHV 115

Query: 181 LVLLQDQGLDLTTVIENLRK 200
           L+LL   GL L T+ + +R+
Sbjct: 116 LLLLVAMGLSLNTLFDVIRR 135


>UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium
           RepID=C4L178_EXISA
          Length = 102

 Score = 82.2 bits (202), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +++LEQL+  RK    E SYT  L+  G ++IA+K GEE  E  +AA      +L  E+
Sbjct: 1   MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL+YHLLVLL  +G+ L  V   L KRH
Sbjct: 59  ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87


>UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae
           RepID=HIS2_RHOBA
          Length = 120

 Score = 81.8 bits (201), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 33/90 (36%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172
            +L   L  R +  PE SYT KL   G + I +K+ EE  E   AA   D   R     E
Sbjct: 9   DRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHAIYE 68

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A DL+YH +VL+  +G++L  V   L +R 
Sbjct: 69  AGDLIYHAMVLMAWRGIELDEVAAELARRE 98


>UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus
           Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK
          Length = 90

 Score = 81.8 bits (201), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  L +L  +RKS+  E SYT KL          KV EE  E   A   +      +E
Sbjct: 3   NTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--IHE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D+ YHLL+ L+   + +  V++ L  R +
Sbjct: 60  AADVFYHLLMYLEANDVKIEEVMQELENRKK 90


>UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae
           RepID=HIS2_METS5
          Length = 93

 Score = 81.4 bits (200), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 38/91 (41%), Positives = 55/91 (60%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L  ++A+R    PE SYTA L   G   +A+KVGEE VE  +A+    R  + +E
Sbjct: 3   DVLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            +DL+YHLLVLL  +G+ L  V + LR+R +
Sbjct: 63  TADLIYHLLVLLAMEGISLDEVRDELRRRMK 93


>UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae
           RepID=HIS2_METS3
          Length = 96

 Score = 80.7 bits (198), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 121 LLAERKSADPETSYTAKLYA----SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
            + E +  +P  SYT+K+          +I +KV EE  E  LAA       L  E+ DL
Sbjct: 12  KVLEERRDNPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND--ENLVYESVDL 69

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++H L++L  +G+++  + E   +R 
Sbjct: 70  IFHTLLILVYKGIEIDEIFEEFARRR 95


>UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis
           RepID=B9RGV5_RICCO
          Length = 193

 Score = 80.3 bits (197), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 24/105 (22%), Positives = 44/105 (41%), Gaps = 7/105 (6%)

Query: 103 SCFGDTAHQWLFLYQLEQLLAERKSADPET-----SYTAKLYASGTKRIAQKVGEEGVET 157
                       LY LE  +++RK+          S+T +L       +  K+ EE  E 
Sbjct: 74  GAVQGKRLALTTLYSLESTISQRKAELAAPQEGKPSWTRRLL-DDPNLLCSKIREEADEL 132

Query: 158 ALAATVHDRF-ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                 ++      +E  D++YH +VLL  + + +  V++ LR+R
Sbjct: 133 CRTLEENEHSIHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177


>UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria
           RepID=HIS2_MYCLB
          Length = 93

 Score = 78.7 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 27/86 (31%), Positives = 35/86 (40%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                L   L+ER    P  S T      G   + +K+ EE  E  LAA    +  L  E
Sbjct: 8   KTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEE 67

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S L+Y   VL+  +GL L  V   L
Sbjct: 68  ISQLLYWTQVLMISRGLSLDDVYRKL 93


>UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZIN5_PLALI
          Length = 98

 Score = 78.4 bits (192), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 24/89 (26%), Positives = 43/89 (48%), Gaps = 3/89 (3%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172
            +LE  L  R    P  SY  +L  +G   +A  + E+  +   A    D     ++   
Sbjct: 6   KRLEAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPAA 65

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           A+++++H ++LL+  G DL+TV   L +R
Sbjct: 66  AANVLFHWMLLLKAYGHDLSTVERELMQR 94


>UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales
           RepID=Q0F926_9RHOB
          Length = 105

 Score = 77.2 bits (189), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 32/86 (37%), Positives = 55/86 (63%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L Q +  RK+   E SY ++L  SG+++ A+K GEE VE  +AA   D+  LT E++D+
Sbjct: 7   RLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEESADV 66

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++H+LV+L    +D  +V++ L +R 
Sbjct: 67  LFHMLVMLSSCDVDFKSVLKELERRE 92


>UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WMR5_EGGLE
          Length = 163

 Score = 76.4 bits (187), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 34/134 (25%), Positives = 48/134 (35%), Gaps = 35/134 (26%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
           S     ++        L   +A R+ A  E SYT +L       + +KV EE  ETALAA
Sbjct: 9   SGEMPPSSQIGATFEALAATIAARREAG-EESYTYRLLTGSLDGVLKKVMEEAGETALAA 67

Query: 162 TVHDR----------------------------------FELTNEASDLMYHLLVLLQDQ 187
              +                                     L  EA+D++YHLLV+L+  
Sbjct: 68  KDVESWACSSLAASIAASGAVDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERY 127

Query: 188 GLDLTTVIENLRKR 201
           G+ L      L  R
Sbjct: 128 GIGLDEFAAELNNR 141


>UniRef50_C0GPL2 Type III restriction protein res subunit n=1
           Tax=Desulfonatronospira thiodismutans ASO3-1
           RepID=C0GPL2_9DELT
          Length = 978

 Score = 71.4 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 19/106 (17%), Positives = 40/106 (37%), Gaps = 7/106 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVET 157
           H  +   +     +         ++ E+      +S + + +        QK+ EE  E 
Sbjct: 4   HSNSHPIYYYKLVRDKIP----SIIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYEL 56

Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             A    D+  +  E+SD++   L +L+ Q      ++  L KR +
Sbjct: 57  FTAIANGDKESVLKESSDVLEITLTILKQQNYSFDDLLAELEKRRE 102


>UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria
           RepID=HIS2_METS4
          Length = 107

 Score = 63.7 bits (154), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 59/92 (64%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  L++++  R +A P+ SYTAKL A+G  + A+K+GEE VE A+AA   DR  L
Sbjct: 1   MTAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +EA+D++YHLLV+L   G+ L  V+  L +R
Sbjct: 61  VSEAADVLYHLLVVLVGSGVALEDVMAELERR 92


>UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1
           Tax=Streptococcus mutans RepID=Q8DTR6_STRMU
          Length = 61

 Score = 59.1 bits (142), Expect = 9e-08,   Method: Composition-based stats.
 Identities = 15/46 (32%), Positives = 25/46 (54%)

Query: 157 TALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             + A   D+ E+ +E +DL+YHL V+L + G+    V   L+ R 
Sbjct: 1   MVIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46


>UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium
           longum DJO10A RepID=UPI00003932E2
          Length = 68

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 15/45 (33%), Positives = 21/45 (46%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
            V  ++ DCD D LLV  + +G  CH G  SCF +     +    
Sbjct: 19  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCFLEGGPLPVVEGH 63


>UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X332_DESRD
          Length = 979

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 27/56 (48%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           QK+ EE  E      V ++  +  E++D++  +L +L+  G     +I  +  R +
Sbjct: 47  QKLLEEAYELFTEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102


>UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ
          Length = 303

 Score = 54.1 bits (129), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
               ++  KV EE  E A A    D   ++ E  DL++ +  L +  G+D  T +     
Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALRDGTA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264



 Score = 39.1 bits (90), Expect = 0.089,   Method: Composition-based stats.
 Identities = 15/59 (25%), Positives = 22/59 (37%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----NLRKRH 202
           EE  E A A    D  +L +E  DL+    +H  +  +        V       L +RH
Sbjct: 60  EEAYEVADAVARGDLRDLRDELGDLLLQVVFHARMAEEQGAFAFDDVARAIGDKLVRRH 118


>UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U6I7_HYDS0
          Length = 251

 Score = 53.3 bits (127), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 16/63 (25%), Positives = 30/63 (47%), Gaps = 4/63 (6%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENL 198
            + +A+ V EE  E   A    D+  +  E +DL+    +H  +  +++  D+  V E L
Sbjct: 27  HESLAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVFELL 86

Query: 199 RKR 201
            K+
Sbjct: 87  IKK 89


>UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SG07_9BACT
          Length = 257

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 15/65 (23%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVIEN---- 197
           I     EE  E   A    D   +  E  D+ +H++   V+ +++G   +  V+      
Sbjct: 32  IKNHFMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVLNEINEK 91

Query: 198 LRKRH 202
           L +RH
Sbjct: 92  LIRRH 96



 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 11/60 (18%), Positives = 21/60 (35%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                  K  EE  E   A     + E+ +E  D+ + L+ L +   ++    +     R
Sbjct: 160 DMHGCMDKFNEEINEFKEAVATGSKDEIEHEMGDVFFSLINLSRFLKINPDEALRRANSR 219


>UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699CB9
          Length = 128

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 5  QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39
          +   ++ W+  +GL+P I Q   +G++LM+ +MN 
Sbjct: 3  EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36


>UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae
           RepID=HIS2_PYRIL
          Length = 94

 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 39/94 (41%), Positives = 54/94 (57%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE+++  R       SYT +LY+SG   +A+KVGEE VE A+AA    +  +
Sbjct: 1   MSCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRI 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             EA+DL+YHLLVLL   GL L  V   L +R +
Sbjct: 61  VEEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94


>UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RLE1_FIBSS
          Length = 265

 Score = 47.5 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 15/67 (22%), Positives = 26/67 (38%), Gaps = 8/67 (11%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENL- 198
             +   + EE  E   AA   D+  +  E  D++    +H  V  +     +  VI+ L 
Sbjct: 30  HSLLPYLVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVIQGLC 89

Query: 199 ---RKRH 202
               +RH
Sbjct: 90  EKMVRRH 96


>UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide
           pyrophosphohydrolase domain fusion protein n=1
           Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT
          Length = 258

 Score = 47.5 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A    D  EL +E  DL+    +H  +  +++   +  V 
Sbjct: 27  EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 87  QNISEKMIRRH 97


>UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria
           RepID=A8I3U9_AZOC5
          Length = 283

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 11/56 (19%), Positives = 25/56 (44%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + +  K+ EE  E + A        + +E  DL++ ++ L +  G+D    + 
Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALR 230


>UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6
           Tax=Bacteria RepID=Q3AFK8_CARHZ
          Length = 479

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 17/65 (26%), Positives = 26/65 (40%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----EN 197
           +   V EE  E A A    D  +L  E  DL+    +H  +  ++       V+    E 
Sbjct: 258 LLPYVLEEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVVEGICEK 317

Query: 198 LRKRH 202
           L +RH
Sbjct: 318 LIRRH 322


>UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A3P2_NATTJ
          Length = 384

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 12/54 (22%), Positives = 20/54 (37%), Gaps = 4/54 (7%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR 199
           + EE  E   A    +   +  E  DL+    +H  V  +     L  V+  L+
Sbjct: 143 LIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVLTKLK 196


>UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D9Q9_9ACTN
          Length = 336

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 18/68 (26%), Positives = 26/68 (38%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTV---- 194
            + I + + EE  E   A    D   L  E  D++     H  + L +Q   L  V    
Sbjct: 58  HESITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVCHGL 117

Query: 195 IENLRKRH 202
            E L +RH
Sbjct: 118 AEKLIRRH 125


>UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GIZ4_9FIRM
          Length = 481

 Score = 45.6 bits (107), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D  +L  E  DL+    +H  +  ++Q      ++
Sbjct: 250 EQDHHSLKPYLLEEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIV 309

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 310 AGITEKLVRRH 320


>UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NET9_KYTSD
          Length = 144

 Score = 45.6 bits (107), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 15/61 (24%), Positives = 22/61 (36%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVIENLR----KR 201
           V EE  E   A    D   L  E  DL++    H  +  +     +  V+  L     +R
Sbjct: 42  VLEEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVVAELEAKLLRR 101

Query: 202 H 202
           H
Sbjct: 102 H 102


>UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD
          Length = 396

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 13/60 (21%), Positives = 24/60 (40%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +  K+ EE  E   A   +DR  + +E  D+++ L  L +  G      +    +R
Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234


>UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1PZU0_9BACT
          Length = 283

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A       +L  E +DL    ++H  +  + +  D+  V+    + + +R
Sbjct: 57  LVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVMKLCLDKMMRR 116

Query: 202 H 202
           H
Sbjct: 117 H 117


>UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM
          Length = 264

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 27/72 (37%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV 194
                  IA+   EE  E   +   +D   L  E  DL+YH+L    +  +        V
Sbjct: 28  LQQNFASIAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDV 87

Query: 195 IENLR----KRH 202
           I+ L     +RH
Sbjct: 88  IQQLAAKLIRRH 99


>UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9
          Length = 302

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
           +  + +  KV EE  E   A       E+  E  DL++ +  L +   +D    I     
Sbjct: 200 ADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIRSTNA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264


>UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frankia sp. CcI3
           RepID=Q2J4X9_FRASC
          Length = 116

 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 24/93 (25%), Positives = 34/93 (36%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
                      +L   LAE+       S T      G   + +K+ EE  E  +AA    
Sbjct: 24  SSNVSNLKTFDELFVELAEKWRRRTPGSGTVAALDQGVHHLGKKLVEEAAEAWMAAEHEG 83

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           R     E S L+Y   +L+   GL L  V  +L
Sbjct: 84  RGRAAEEISQLLYWSQLLMISLGLSLDDVYSHL 116


>UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=Actinomycetales
           RepID=A4F800_SACEN
          Length = 334

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 13/66 (19%), Positives = 21/66 (31%), Gaps = 8/66 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDL---T 192
                 + + + EE  E   A    DR  L  E  D    +++H  +   +   D     
Sbjct: 125 EQDHDTLRKYLVEETYELLDAIEQRDRDALREELGDVLLQVLFHARIA-AEHDADPFGVD 183

Query: 193 TVIENL 198
            V   L
Sbjct: 184 EVAAEL 189


>UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF
          Length = 289

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E A A    D  ++  E  D++    +H  +  + Q  DL  VI      L +RH
Sbjct: 59  EEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDVIYTLQSKLIRRH 117


>UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LC99_MAGSM
          Length = 277

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 16/55 (29%), Positives = 25/55 (45%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            T  I  K+ EE  E A A   +DR     E  DL++ L+ L +   ++  T + 
Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233


>UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640_PELTS
          Length = 582

 Score = 44.8 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D ++   E  DL+    +H  +  +++  D+  VI
Sbjct: 345 EQDHRTLKPYLLEEAYEVIEALDEEDMYKTCEELGDLLLQIVFHAQIAAENRHFDINDVI 404

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 405 AGISEKMIRRH 415


>UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX RepID=Q47SV3_THEFY
          Length = 246

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 17/70 (24%), Positives = 28/70 (40%), Gaps = 10/70 (14%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQD--QGLDLTTV-- 194
            + +A+ + EE  ET       D   L  E  D++    +H  V  +    G  +  V  
Sbjct: 35  HESLAKYLIEEAYETVETIERGDYDTLAEELGDVLLQVVFHARVAAERGPDGFTIDDVAD 94

Query: 195 --IENLRKRH 202
             I+ L +RH
Sbjct: 95  AIIDKLVRRH 104


>UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGC7_KOSOT
          Length = 256

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    +  E   E  DL+    +H  +  +     +  V+    + L +R
Sbjct: 38  LIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVVETLSDKLIRR 97

Query: 202 H 202
           H
Sbjct: 98  H 98


>UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces
           RepID=D1X3V9_9ACTO
          Length = 335

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 20/79 (25%), Positives = 31/79 (39%), Gaps = 13/79 (16%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG- 188
           +T++    G   +A+   EE  E   A    DR EL  E  D++    +H  +  +D   
Sbjct: 147 WTSRKTHRG---LAKYAIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEDPDE 203

Query: 189 -LDLTTVI----ENLRKRH 202
              +  V     E L  RH
Sbjct: 204 PFAVDDVAGGLVEKLIHRH 222


>UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepID=C8XKR8_NAKMY
          Length = 240

 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 15/69 (21%), Positives = 26/69 (37%), Gaps = 12/69 (17%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQ----DQGLDLTTVI-- 195
           + + + EE  E   A    DR  +  E  D    +++H  +  +      G D+  V   
Sbjct: 40  LVRYLLEECYELVEAVESGDRAAIREELGDVLLQVLFHARIAAETPRDQGGFDIDDVAGD 99

Query: 196 --ENLRKRH 202
               L +RH
Sbjct: 100 LVAKLVRRH 108


>UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=C9N950_9ACTO
          Length = 328

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTT 193
               + +A+   EE  E   A    DR EL  E  D++    +H  +  +DQ     +  
Sbjct: 140 QKTHQGLAKYAIEEAYELVEAIEDGDREELREELGDVLLQVVFHARIAQEDQEEPFGIDD 199

Query: 194 VIE----NLRKRH 202
           V       L  RH
Sbjct: 200 VAATIVEKLIHRH 212


>UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL
          Length = 180

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 12/51 (23%), Positives = 21/51 (41%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
           + EE  E +  A       L  E +D++Y         G+DL  V+  + +
Sbjct: 85  LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135


>UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC0_DESHD
          Length = 493

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 14/68 (20%), Positives = 24/68 (35%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI--- 195
              +   + EE  E   A    D + L  E  DL+    +H  V  +        V+   
Sbjct: 252 HDSLKPYLIEESYEVLEAIEAQDMYNLAEELGDLLLQVVFHAQVAQEAGEFQFQDVLKGI 311

Query: 196 -ENLRKRH 202
            + + +RH
Sbjct: 312 IDKMIRRH 319


>UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RA19_AMMDK
          Length = 495

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 12/62 (19%), Positives = 25/62 (40%), Gaps = 6/62 (9%)

Query: 146 IAQKVGEEGVETALAA--TVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR 199
           + + + EE  E   A      D   L  E  DL+    +H  +  +    +L  V+ ++ 
Sbjct: 262 LKKYLLEETYEVLEAIDRVEEDPHNLCEELGDLLLQIVFHCQIAAEAGRFNLDDVVRSIT 321

Query: 200 KR 201
           ++
Sbjct: 322 RK 323


>UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MG87_RHOM4
          Length = 283

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVI----ENLRKR 201
           + EE  E   A   +D  EL  E  DL+ H++   V+ +  G   L  VI    E L +R
Sbjct: 52  LIEEAYEVVSAIEENDWEELKRELGDLLLHVVFHSVMAEQAGRFTLKDVIETETEKLIRR 111

Query: 202 H 202
           H
Sbjct: 112 H 112


>UniRef50_B3DW98 Predicted pyrophosphatase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DW98_METI4
          Length = 269

 Score = 42.5 bits (99), Expect = 0.008,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVIENLR----KR 201
           + EE  E   A    D   +  E  D    +++H  +  +        +++NL     +R
Sbjct: 51  LIEECYELLEAIDQEDPSSIKEELGDILLHVLFHAQIAQEAGKFSFWDILDNLSAKLIRR 110

Query: 202 H 202
           H
Sbjct: 111 H 111



 Score = 41.4 bits (96), Expect = 0.018,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 23/57 (40%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
              +    K+ EE  E   A    +R ++  E  DL++  +   +  G+D    I+ 
Sbjct: 173 KDPQGPLSKMQEELDEIKEAYGEKNREKIKKEIGDLIFSAVNFSRMLGIDPEEAIKE 229


>UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3J2_SALRD
          Length = 281

 Score = 42.5 bits (99), Expect = 0.010,   Method: Composition-based stats.
 Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVI----ENLRKR 201
           + EE  E   A    D  EL  E  D++ H+L   V+ ++ G   L  VI    + L +R
Sbjct: 56  LIEEAYEVVAAIDHGDWDELAEELGDVLLHVLFHAVIAEEGGRFTLADVIEAETDKLVRR 115

Query: 202 H 202
           H
Sbjct: 116 H 116


>UniRef50_C0QR38 MazG family protein n=4 Tax=Hydrogenothermaceae RepID=C0QR38_PERMH
          Length = 261

 Score = 42.2 bits (98), Expect = 0.010,   Method: Composition-based stats.
 Identities = 17/65 (26%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLR-- 199
           I   + EE  E   A    D   +  E  DL+    +H  +   +   D+  V+ENL+  
Sbjct: 38  IKNNLIEEAYELFEAIESDDDKAMVEELGDLLLQVVFHSQIKKDEGSFDINDVLENLKEK 97

Query: 200 --KRH 202
             +RH
Sbjct: 98  LIRRH 102


>UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C338_SPHTD
          Length = 466

 Score = 42.2 bits (98), Expect = 0.010,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 21/59 (35%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM---Y-HLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E   A    D   L  E  DL+   Y H  +  +     L  VI      L +RH
Sbjct: 272 EEAYEVLEAIERDDAAALREELGDLLLQVYLHAQIAEEAGEFTLEDVIGDLSAKLVRRH 330


>UniRef50_C7MMP1 MazG family protein n=2 Tax=Coriobacteriaceae RepID=C7MMP1_CRYCD
          Length = 307

 Score = 42.2 bits (98), Expect = 0.011,   Method: Composition-based stats.
 Identities = 19/70 (27%), Positives = 29/70 (41%), Gaps = 12/70 (17%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLTTVIE 196
            + IA+ + EE  E   A    DR  L  E  D++  L V+LQ Q         +  V +
Sbjct: 49  HESIAKNMLEEAFEAVAAIEEADRDHLIEELGDVL--LQVVLQAQIAADAGEFTIDDVAQ 106

Query: 197 ----NLRKRH 202
                + +RH
Sbjct: 107 AVNEKIIRRH 116


>UniRef50_B8HTG9 MazG family protein n=2 Tax=Chroococcales RepID=B8HTG9_CYAP4
          Length = 388

 Score = 41.8 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 19/74 (25%), Positives = 26/74 (35%), Gaps = 12/74 (16%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLT 192
            A   + +   V EE  E   A    +   +  E  DL+  L V+LQ Q         L 
Sbjct: 128 LAQTPESLTPYVIEEAYEVVHAIREGEPAAIAEELGDLL--LQVVLQAQIASEQAHFSLR 185

Query: 193 TVI----ENLRKRH 202
            V       L +RH
Sbjct: 186 DVAQSISAKLIRRH 199


>UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax=Bacillales
           RepID=A7GLU0_BACCN
          Length = 108

 Score = 41.8 bits (97), Expect = 0.015,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 29/71 (40%), Gaps = 5/71 (7%)

Query: 129 DPETSYTAKLYASG--TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           +   ++T ++       + + +K  EE  E   A     +     E +DL+  +  L Q 
Sbjct: 18  NNGKTFTTRMLDEQEYIEEVCKKTQEELAEYVEA---ESKEHKVEELADLLELVNALAQH 74

Query: 187 QGLDLTTVIEN 197
           +G+ L  V + 
Sbjct: 75  EGVTLEDVEKV 85


>UniRef50_A8ZVD0 MazG family protein n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZVD0_DESOH
          Length = 269

 Score = 41.8 bits (97), Expect = 0.015,   Method: Composition-based stats.
 Identities = 15/64 (23%), Positives = 27/64 (42%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT----TVIEN 197
            T  +  K+ EE  E   A   +D+  +T E  DL++ L+ L +   +         ++ 
Sbjct: 171 DTAGVMDKIKEEFAELEAAMAENDKAHVTEEVGDLLFSLVNLARFLRVHPETALADTVKK 230

Query: 198 LRKR 201
             KR
Sbjct: 231 FEKR 234



 Score = 41.4 bits (96), Expect = 0.018,   Method: Composition-based stats.
 Identities = 16/61 (26%), Positives = 24/61 (39%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ----GLDLTTVIE----NLRKR 201
           + EE  E   A    D  ++  E  DL++H+L L          DL  V       + +R
Sbjct: 45  LVEEVHELVDAIMEADPAKICEELGDLLFHILFLESIFRGRGDFDLQDVARISAEKMIRR 104

Query: 202 H 202
           H
Sbjct: 105 H 105


>UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TY54_METKA
          Length = 103

 Score = 41.8 bits (97), Expect = 0.016,   Method: Composition-based stats.
 Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 2/54 (3%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           + EE +E   A    +R  L  E  DL+  +   L    +DL  ++E  R+R +
Sbjct: 43  LVEEAIEVRNAVRSGNREALIEELGDLLIEVEAFLTAHDIDLEEIVE--RQRTK 94


>UniRef50_Q0S4J7 Putative uncharacterized protein n=4 Tax=Nocardiaceae
           RepID=Q0S4J7_RHOSR
          Length = 288

 Score = 41.4 bits (96), Expect = 0.018,   Method: Composition-based stats.
 Identities = 22/131 (16%), Positives = 41/131 (31%), Gaps = 7/131 (5%)

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131
             V ++  +     +LV  +P  P            +          + L+   +  D  
Sbjct: 34  QGVRTLLTEAPGAAVLVSTDPDHP---TVREWVASGSRVIAAPKVPGDNLVEAAEVMDRL 90

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQ 187
            SY         + ++  + EE  E   A    +R +L  E  DL    ++H  +     
Sbjct: 91  WSYGGWEVTQTHRTLSHYLVEETYEVLDAIESSERADLREELGDLLLQVLFHSRIASASG 150

Query: 188 GLDLTTVIENL 198
             D+  V   L
Sbjct: 151 HFDVDDVAATL 161


>UniRef50_D2RFM2 MazG nucleotide pyrophosphohydrolase n=3 Tax=Euryarchaeota
           RepID=D2RFM2_ARCPR
          Length = 96

 Score = 41.4 bits (96), Expect = 0.018,   Method: Composition-based stats.
 Identities = 14/64 (21%), Positives = 27/64 (42%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193
           Y  +    G ++    + EE  E A A   +D   +  E +D+   L+ L     +DL +
Sbjct: 14  YYERDLKRGKEKTMLWLVEEIGELAEAVRKNDLNSIREEMADVFAWLVSLANLYDVDLES 73

Query: 194 VIEN 197
            ++ 
Sbjct: 74  AVKE 77


>UniRef50_A9FF91 Putative uncharacterized protein mazG n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9FF91_SORC5
          Length = 284

 Score = 41.4 bits (96), Expect = 0.019,   Method: Composition-based stats.
 Identities = 17/65 (26%), Positives = 24/65 (36%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----N 197
           + + V EE  E   A    DR EL  E  DL+    +   +   +       VI      
Sbjct: 48  LRRYVLEEACEVIDAIDGGDRKELCAELGDLLLQVVFQAELARAEGAFGPDDVIAAICEK 107

Query: 198 LRKRH 202
           L +RH
Sbjct: 108 LVRRH 112


>UniRef50_C9XSA1 Putative bifunctional protein [include tetrapyrrole
           (Corrin/Porphyrin) methylase and nucleoside triphosphate
           pyrophosphohydrolase] n=7 Tax=Clostridium
           RepID=C9XSA1_CLODC
          Length = 491

 Score = 41.4 bits (96), Expect = 0.020,   Method: Composition-based stats.
 Identities = 16/61 (26%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           V EE  E   A   +D  E+  E  D++    +H  +  ++   DL  V+    + L  R
Sbjct: 271 VIEEAYELCNAIDNNDIDEMVEELGDVLLQVIFHCQIGNEEGYFDLKEVVNGICKKLIHR 330

Query: 202 H 202
           H
Sbjct: 331 H 331


>UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Gluconacetobacter
           diazotrophicus PAl 5 RepID=A9H4J7_GLUDA
          Length = 148

 Score = 41.0 bits (95), Expect = 0.022,   Method: Composition-based stats.
 Identities = 13/59 (22%), Positives = 24/59 (40%)

Query: 145 RIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           RIA+  G       +     DR  L  E+++ +  L+ +   + +    V   L +R Q
Sbjct: 58  RIARAFGLHAEHCVMELIADDRAALIRESAETLTRLMQIWAARNVSADAVWTELDRRTQ 116


>UniRef50_B0CCR5 MazG family protein n=8 Tax=Cyanobacteria RepID=B0CCR5_ACAM1
          Length = 411

 Score = 41.0 bits (95), Expect = 0.023,   Method: Composition-based stats.
 Identities = 17/63 (26%), Positives = 24/63 (38%), Gaps = 12/63 (19%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLTTVIE----NLR 199
           + EE  ET  A        +  E  DL+  L V+LQ Q         L  + +     L 
Sbjct: 144 IIEEAYETIDAIQSGSTEAIAEELGDLL--LQVVLQAQIACEQDQFSLEEIAQGITKKLI 201

Query: 200 KRH 202
           +RH
Sbjct: 202 RRH 204


>UniRef50_B2TI15 MazG family protein n=5 Tax=Clostridium RepID=B2TI15_CLOBB
          Length = 488

 Score = 41.0 bits (95), Expect = 0.023,   Method: Composition-based stats.
 Identities = 9/36 (25%), Positives = 14/36 (38%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + I   + EE  E   A    D   L  E  D+++
Sbjct: 253 HESIKNSLIEESYEVVDAINNEDDDSLIEELGDVLF 288


>UniRef50_B7JWE8 MazG nucleotide pyrophosphohydrolase n=2 Tax=Cyanothece
           RepID=B7JWE8_CYAP8
          Length = 110

 Score = 41.0 bits (95), Expect = 0.025,   Method: Composition-based stats.
 Identities = 15/61 (24%), Positives = 24/61 (39%), Gaps = 4/61 (6%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + +  K+ EE  E   A    D   L  E  DL   +  +L    +   TVI   ++R 
Sbjct: 35  LEALKHKLLEEAQEVIEA----DPENLVKELGDLFEVIDNILIAYQISRETVINYQQQRR 90

Query: 203 Q 203
           +
Sbjct: 91  K 91


>UniRef50_A2CDV8 MazG family protein n=11 Tax=Cyanobacteria RepID=A2CDV8_PROM3
          Length = 332

 Score = 41.0 bits (95), Expect = 0.025,   Method: Composition-based stats.
 Identities = 15/61 (24%), Positives = 24/61 (39%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----NLRKR 201
           + EE  E A A    D   L+ E  DL+     H  +  ++   +L  +       L +R
Sbjct: 98  MLEEAHEVADAIRNGDDNHLSEELGDLLLQVVLHAQIANEEGRFNLEDIARSISAKLIRR 157

Query: 202 H 202
           H
Sbjct: 158 H 158



 Score = 39.1 bits (90), Expect = 0.096,   Method: Composition-based stats.
 Identities = 13/53 (24%), Positives = 23/53 (43%)

Query: 149 KVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           KV EE  E   A    D+     E  D+++ L+ + +  GL+    +    +R
Sbjct: 234 KVQEEFEELKEAVEHEDQAHAQTELGDVLFTLVNVARWCGLNPEEGLAGTNQR 286


>UniRef50_B5JET8 MazG family protein n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JET8_9BACT
          Length = 267

 Score = 41.0 bits (95), Expect = 0.025,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +AQ + +E  E        D   +  E  D++    +H  + ++    D   V 
Sbjct: 68  EQDHQSLAQCLVDECSELLETIDKLDMDHMREELGDVLLQVVFHAQLAMEAGHFDFDAVA 127

Query: 196 EN----LRKRH 202
                 L +RH
Sbjct: 128 AEINEKLVRRH 138


>UniRef50_A6LPK0 MazG family protein n=10 Tax=Clostridia RepID=A6LPK0_CLOB8
          Length = 483

 Score = 41.0 bits (95), Expect = 0.026,   Method: Composition-based stats.
 Identities = 17/68 (25%), Positives = 27/68 (39%), Gaps = 9/68 (13%)

Query: 144 KRIAQK-VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE-- 196
            +  +K + EE  E   A    D   L  E  D++    +H  +  +D   D+  VIE  
Sbjct: 253 HKSLKKALIEESYEVIDAIDQDDDNSLIEELGDVLLQVVFHASIGKEDGYFDIGDVIEGI 312

Query: 197 --NLRKRH 202
              +  RH
Sbjct: 313 CNKMISRH 320


>UniRef50_Q04VW6 Pyrophosphatase n=6 Tax=Leptospira RepID=Q04VW6_LEPBJ
          Length = 296

 Score = 41.0 bits (95), Expect = 0.027,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 22/61 (36%), Gaps = 4/61 (6%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A   +D   L  E  DL+    +H  +  +    DL  V 
Sbjct: 56  EQDHQTLIPYLIEESQEVIEAILKNDDELLKEELGDLLFQVVFHARLAEERHSFDLGDVA 115

Query: 196 E 196
           +
Sbjct: 116 K 116


>UniRef50_D2LXK4 MazG family protein n=2 Tax=Bacillus RepID=D2LXK4_BACS4
          Length = 494

 Score = 40.6 bits (94), Expect = 0.029,   Method: Composition-based stats.
 Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 12/70 (17%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL-----QDQGL-DLTTVIE 196
            + + + + EE  E   A    +  +L  E  D++  L V+L     +D G+  +  VIE
Sbjct: 257 HESLKKYLIEEAYEVLDAIDKGNEDDLVEELGDVL--LQVVLHSQIGEDNGIFSIDQVIE 314

Query: 197 NLR----KRH 202
            L     +RH
Sbjct: 315 TLTEKMIRRH 324


>UniRef50_A8L147 MazG family protein n=4 Tax=Frankia RepID=A8L147_FRASN
          Length = 436

 Score = 40.6 bits (94), Expect = 0.029,   Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 26/67 (38%), Gaps = 10/67 (14%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQD--QGLDLTTVI---- 195
           +A  + EE  E   A    D  EL  E  D    +++H  +  +    G D+  V     
Sbjct: 171 LAPYLLEEAYEAYQAIEDGDLAELREELGDVLMQVLFHARIAAESGGAGWDVDDVAAGLT 230

Query: 196 ENLRKRH 202
             L +RH
Sbjct: 231 AKLIRRH 237


>UniRef50_C8WFT9 MazG family protein n=3 Tax=Zymomonas mobilis RepID=C8WFT9_ZYMMN
          Length = 273

 Score = 40.6 bits (94), Expect = 0.031,   Method: Composition-based stats.
 Identities = 16/59 (27%), Positives = 23/59 (38%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKRH 202
           EE  E   A    D  EL NE  DL+    +H  +  +        V+    E + +RH
Sbjct: 50  EEAYEVVDAIEQQDMHELKNELGDLLLQVVFHSQMAAEKDLFTFDDVVTAICEKMIRRH 108


>UniRef50_B0K4Q4 MazG family protein n=10 Tax=Clostridia RepID=B0K4Q4_THEPX
          Length = 495

 Score = 40.6 bits (94), Expect = 0.032,   Method: Composition-based stats.
 Identities = 8/53 (15%), Positives = 20/53 (37%), Gaps = 4/53 (7%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE 196
           + + EE  E   A       ++  E  D++    +H  +  +    +   V++
Sbjct: 264 KYLVEESYELVDAIEKESEDKMVEELGDVLLQVVFHSQIAKERGTFNFGDVVD 316


>UniRef50_D0LI16 MazG family protein n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LI16_HALO1
          Length = 289

 Score = 40.6 bits (94), Expect = 0.033,   Method: Composition-based stats.
 Identities = 15/56 (26%), Positives = 24/56 (42%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
             T   + KV EE  E   AA   D+  +  E  DL++ ++ L +  G D    + 
Sbjct: 189 EDTAGCSAKVREELGEVEHAAASGDQAAVEAEIGDLLFAVVSLARKHGCDPEHALR 244


>UniRef50_B5HJI9 Nucleoside triphosphate pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=B5HJI9_STRPR
          Length = 293

 Score = 40.6 bits (94), Expect = 0.033,   Method: Composition-based stats.
 Identities = 13/51 (25%), Positives = 22/51 (43%), Gaps = 7/51 (13%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHL 180
           ++++    G   +A+   EE  E   A    DR EL  E  D++    +H 
Sbjct: 101 WSSQQTHKG---LAKYGIEEAYELVEAIEDGDRDELREELGDVLLQVVFHA 148


>UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG family protein n=15
           Tax=Bacteria RepID=A4IJD4_GEOTN
          Length = 486

 Score = 40.6 bits (94), Expect = 0.034,   Method: Composition-based stats.
 Identities = 16/56 (28%), Positives = 27/56 (48%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + I QKV EE  E     +   R EL +E  D+M+ L+ L +  G+     ++
Sbjct: 387 NDVEPIWQKVEEEMAEFRAETSSGRRAELVSEFGDVMFALINLARYYGIQPEEALQ 442


>UniRef50_Q0B0R5 MazG protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str.
           Goettingen RepID=Q0B0R5_SYNWW
          Length = 255

 Score = 40.6 bits (94), Expect = 0.035,   Method: Composition-based stats.
 Identities = 11/55 (20%), Positives = 23/55 (41%), Gaps = 3/55 (5%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           G +   +K  EE  E   A       E+  E  D+ + L+ + + + +D    ++
Sbjct: 160 GVEGALEKFKEEVEELVAATK---PEEIKEEMGDVFFALVNVARLKNIDPEEALQ 211


>UniRef50_Q2LVG8 MazG-like domain protein n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVG8_SYNAS
          Length = 273

 Score = 40.6 bits (94), Expect = 0.036,   Method: Composition-based stats.
 Identities = 14/51 (27%), Positives = 23/51 (45%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  K+ EE  E   A    DR  +T E  DL + L+ L +   +D    ++
Sbjct: 178 VIAKIEEELDELKAAIRTGDREHITEETGDLFFSLVNLCRFFSMDAEQTLQ 228



 Score = 39.8 bits (92), Expect = 0.054,   Method: Composition-based stats.
 Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ------DQGLD--LTTVIEN 197
           I + + +E  E   A       +L  E  DL++ +L L Q      + G+   L  V   
Sbjct: 44  IGRYLLDESYEVLDAVASGGSEDLKEELGDLLFQILFLAQIAEESGEFGIADVLEEVTAK 103

Query: 198 LRKRH 202
           + +RH
Sbjct: 104 MIRRH 108


>UniRef50_Q1K0K7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Desulfuromonas
           acetoxidans DSM 684 RepID=Q1K0K7_DESAC
          Length = 235

 Score = 40.2 bits (93), Expect = 0.038,   Method: Composition-based stats.
 Identities = 16/68 (23%), Positives = 28/68 (41%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM---YHLLVLLQDQG-LDLTTV---- 194
              I + + EE  E   A   +   ++ +E  DL+   Y L  + ++ G  +L  V    
Sbjct: 36  PDTIKKHLLEEAYEVLDAIDHNISEDICSELGDLLMQIYFLADIYEEAGQFELFDVSEAI 95

Query: 195 IENLRKRH 202
              L +RH
Sbjct: 96  QAKLIRRH 103


>UniRef50_D1W9A9 MazG family protein n=5 Tax=Prevotella RepID=D1W9A9_9BACT
          Length = 294

 Score = 40.2 bits (93), Expect = 0.039,   Method: Composition-based stats.
 Identities = 16/59 (27%), Positives = 23/59 (38%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV----IENLRKRH 202
           EE  E   A    D+  +  E  D+M H+L    +  +    DL  V     + L  RH
Sbjct: 53  EEVYELCDALLNDDKKNICKELGDVMEHVLFYSILGEETHDFDLADVCNKQADKLMFRH 111


>UniRef50_B0VJQ1 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VJQ1_9BACT
          Length = 255

 Score = 40.2 bits (93), Expect = 0.043,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 30/61 (49%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
              K I +K+ EE  E A A   +++  +  E  D+++ L+ + +   +D  + ++   +
Sbjct: 158 QDIKPILEKLDEERDELAEALNSNEQDAIKEELGDMIFTLVNMARKLHIDAESALKECIR 217

Query: 201 R 201
           +
Sbjct: 218 K 218



 Score = 39.5 bits (91), Expect = 0.075,   Method: Composition-based stats.
 Identities = 19/61 (31%), Positives = 29/61 (47%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLV---LLQDQGL-DLTTVIEN----LRKR 201
             EE  E   A    D   L  E  DLM H+++   + ++QGL ++  V+E     L +R
Sbjct: 36  FIEELYEVVEAIENKDYDALKEELGDLMLHIVMQAQISKEQGLWNIDDVLEEISSKLIRR 95

Query: 202 H 202
           H
Sbjct: 96  H 96


>UniRef50_B1J1L8 MazG family protein n=14 Tax=Bacteria RepID=B1J1L8_PSEPW
          Length = 277

 Score = 40.2 bits (93), Expect = 0.044,   Method: Composition-based stats.
 Identities = 22/111 (19%), Positives = 34/111 (30%), Gaps = 13/111 (11%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYAS---------GTKRIAQKVGEEGVE 156
                      +   LL +  +A P  S  AKL                +  KV EE  E
Sbjct: 128 KAQERAEKSEPEQLSLLDDVPAALPALSRAAKLQKRAATVGFDWPDALPVLDKVREELDE 187

Query: 157 TALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRKRHQ 203
              A    D   L +E  DL++  + L +    D    +        +R +
Sbjct: 188 VLQAMADGDAEALEDEVGDLLFAAVNLARHLKQDPENALRRANRKFERRFR 238


>UniRef50_Q6AK03 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AK03_DESPS
          Length = 145

 Score = 40.2 bits (93), Expect = 0.045,   Method: Composition-based stats.
 Identities = 15/69 (21%), Positives = 26/69 (37%), Gaps = 12/69 (17%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL------QDQGLDLTTVIEN 197
           + I + +  E  E   A    D   +  E  D++Y  +V+L      ++    L  V   
Sbjct: 34  ESIIKYLKSESQELIDALEKKDYPNICEELGDVLY--IVILISSINKKEGQFSLEDVFRE 91

Query: 198 ----LRKRH 202
               L +RH
Sbjct: 92  VNAKLVRRH 100


>UniRef50_Q7V9I6 Predicted pyrophosphatase n=1 Tax=Prochlorococcus marinus
           RepID=Q7V9I6_PROMA
          Length = 276

 Score = 39.8 bits (92), Expect = 0.048,   Method: Composition-based stats.
 Identities = 11/59 (18%), Positives = 22/59 (37%), Gaps = 8/59 (13%)

Query: 152 EEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----NLRKRH 202
           EE  E   A    +  +L  E  DL+     H  +  +++      + +     + +RH
Sbjct: 47  EEAYEVCDAIRYGNDSDLIEELGDLLLQVVLHAQIANEEKRFCFDDIAQTAAEKMIRRH 105


>UniRef50_Q3Z619 MazG family protein n=5 Tax=Dehalococcoides RepID=Q3Z619_DEHE1
          Length = 264

 Score = 39.8 bits (92), Expect = 0.048,   Method: Composition-based stats.
 Identities = 15/65 (23%), Positives = 25/65 (38%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----N 197
           +   + EE  E   A    D      E  DL+    +H  +  + +  ++  VIE     
Sbjct: 37  MRDSLLEETYEVLEALDAEDTGRFCGELGDLLLQIVFHAEIGAEAKEFNMGDVIEAINTK 96

Query: 198 LRKRH 202
           L +RH
Sbjct: 97  LIRRH 101


>UniRef50_Q2JT55 MazG family protein n=4 Tax=Bacteria RepID=Q2JT55_SYNJA
          Length = 364

 Score = 39.8 bits (92), Expect = 0.048,   Method: Composition-based stats.
 Identities = 21/63 (33%), Positives = 26/63 (41%), Gaps = 12/63 (19%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLTTVIE----NLR 199
           + EE  ET  A    D   +  E  DL+  L V+LQ Q        DL TV       L 
Sbjct: 126 ILEEAYETVAAIRAGDPAAIAEELGDLL--LQVVLQSQIFAERNHFDLETVAARIADKLI 183

Query: 200 KRH 202
           +RH
Sbjct: 184 RRH 186


>UniRef50_C7RAH4 MazG family protein n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAH4_KANKD
          Length = 266

 Score = 39.8 bits (92), Expect = 0.057,   Method: Composition-based stats.
 Identities = 12/58 (20%), Positives = 26/58 (44%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           + +KV EE  E   A   +D+  +  E  DL++  + L +   +D    +    ++ +
Sbjct: 176 VIEKVEEEIAELKQAIANNDQQNIEEEIGDLLFSCVNLSRHLKVDAEAALRKSSRKFE 233


>UniRef50_Q3AVT5 MazG n=4 Tax=Cyanobacteria RepID=Q3AVT5_SYNS9
          Length = 270

 Score = 39.8 bits (92), Expect = 0.059,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
                +  KV EE  E   A    D+     E  DL++ L+ + +  G+     +    +
Sbjct: 170 DDMAGVWAKVHEELDELKEAVISGDQSHAQEELGDLLFTLVNVARWCGIAPEEGLAGTNR 229

Query: 201 R 201
           R
Sbjct: 230 R 230



 Score = 39.5 bits (91), Expect = 0.073,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +   V EE  E A A    D   L  E  DL+     H  +  +     L+ V
Sbjct: 30  LEQTHASLVPYVLEEAHEVADAIRHGDDAHLKEELGDLLLQVVLHAQIAKEGNRFALSDV 89

Query: 195 I----ENLRKRH 202
                  L +RH
Sbjct: 90  ADGINAKLIRRH 101


>UniRef50_Q7D8Z6 Transcriptional regulator, MazG family n=3 Tax=Mycobacterium
           RepID=Q7D8Z6_MYCTU
          Length = 294

 Score = 39.8 bits (92), Expect = 0.059,   Method: Composition-based stats.
 Identities = 11/65 (16%), Positives = 22/65 (33%), Gaps = 6/65 (9%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVL--LQDQGLDLTTVIE 196
              + + + EE  E   A       +L  E  DL    ++H  +          +  V +
Sbjct: 78  HDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVAD 137

Query: 197 NLRKR 201
            L ++
Sbjct: 138 TLMRK 142


>UniRef50_B5YFB4 MazG n=2 Tax=Dictyoglomus RepID=B5YFB4_DICT6
          Length = 258

 Score = 39.8 bits (92), Expect = 0.059,   Method: Composition-based stats.
 Identities = 12/54 (22%), Positives = 26/54 (48%), Gaps = 4/54 (7%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVIENLR 199
             EE  E   A   +D+  +  E  D++ H+L   ++ +++   +   V +NL+
Sbjct: 40  FLEEAYELIDALEKNDQEMIKEELGDILLHVLMQSIMAEEKNRFNFEEVCKNLK 93



 Score = 39.1 bits (90), Expect = 0.093,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 29/61 (47%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
             +K I  K+ EE  E   A    ++ ++  E  DL++ ++ + +  G+D  + +    K
Sbjct: 161 KNSKEIIPKLYEELKELEKAIQEDNKEDMEEEIGDLLFTIVNIARHLGIDPESSLRKTNK 220

Query: 201 R 201
           +
Sbjct: 221 K 221


>UniRef50_B9CMC9 Tetrapyrrole methylase family protein, MazG family protein n=1
           Tax=Atopobium rimae ATCC 49626 RepID=B9CMC9_9ACTN
          Length = 298

 Score = 39.8 bits (92), Expect = 0.059,   Method: Composition-based stats.
 Identities = 16/68 (23%), Positives = 23/68 (33%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVIENL 198
              I + + EE  E   A        L  E  D++     H  +   D G D+  V   L
Sbjct: 62  HDSITKNMIEEAYEAVEAIKEGSSEHLQEELGDVLEQVLLHSQIESDDGGFDIDGVCRAL 121

Query: 199 R----KRH 202
                +RH
Sbjct: 122 NEKLVRRH 129


>UniRef50_B1XI42 MazG family protein n=22 Tax=Cyanobacteria RepID=B1XI42_SYNP2
          Length = 278

 Score = 39.8 bits (92), Expect = 0.060,   Method: Composition-based stats.
 Identities = 20/74 (27%), Positives = 27/74 (36%), Gaps = 12/74 (16%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLT 192
                + +   V EE  E   A    D+  +  E  DL+  L V+LQ Q         L 
Sbjct: 35  LEQTPQTLIPYVIEEAYEVVHALRQDDQQAIAEELGDLL--LQVVLQAQIAQEYGHFSLQ 92

Query: 193 TVI----ENLRKRH 202
            V     E L +RH
Sbjct: 93  EVAEGISEKLIRRH 106


>UniRef50_Q3JCR4 Tetrapyrrole methylase family protein / MazG family protein n=2
           Tax=Nitrosococcus oceani RepID=Q3JCR4_NITOC
          Length = 180

 Score = 39.5 bits (91), Expect = 0.063,   Method: Composition-based stats.
 Identities = 14/63 (22%), Positives = 26/63 (41%), Gaps = 5/63 (7%)

Query: 146 IAQKVGEEGVETALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRK 200
           I +K+ EE  E   A T   +   L  E  DL++  + L +  G+     +    +   +
Sbjct: 82  ILEKIEEELQEVRAALTSNENSSRLQEEIGDLLFACINLARHTGIMPEAALDSCSDKFER 141

Query: 201 RHQ 203
           R +
Sbjct: 142 RFR 144


>UniRef50_Q6MDA8 Putative uncharacterized protein n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MDA8_PARUW
          Length = 217

 Score = 39.5 bits (91), Expect = 0.064,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 29/65 (44%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL--LQDQG--LDLTTVIEN---- 197
           +   V EE  E   A  + +  ++  E  DL ++++ L  L ++     L  +++     
Sbjct: 31  MRSSVIEEVYELVEAIDLENNEKIKEELGDLCFNVIFLGKLAERDKKFSLHDMLKEINEK 90

Query: 198 LRKRH 202
           L +RH
Sbjct: 91  LIRRH 95


>UniRef50_Q6G3M6 MazG protein n=1 Tax=Bartonella henselae RepID=Q6G3M6_BARHE
          Length = 273

 Score = 39.5 bits (91), Expect = 0.068,   Method: Composition-based stats.
 Identities = 14/61 (22%), Positives = 25/61 (40%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    +R +L +E  DL+    YH  +  ++       V+      + +R
Sbjct: 39  MLEEVYEVIDAIERKNRTDLCDELGDLLLQVVYHATIAQEEGSFTFEDVVYAITSKMIRR 98

Query: 202 H 202
           H
Sbjct: 99  H 99


>UniRef50_Q0A8N1 MazG family protein n=4 Tax=Proteobacteria RepID=Q0A8N1_ALHEH
          Length = 292

 Score = 39.5 bits (91), Expect = 0.071,   Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
            A     IA    EE  E A A    D  +L +E  DL+    +H  +  ++       V
Sbjct: 51  LAQDFASIAPYTLEEAYEVAEAIRRGDMADLQDELGDLLLQVVFHARMAEEEGFFTFEDV 110

Query: 195 IE----NLRKRH 202
                  L +RH
Sbjct: 111 ARSISDKLVRRH 122


>UniRef50_C0QWZ2 Nucleoside triphosphate pyrophosphohydrolase n=2 Tax=Brachyspira
           RepID=C0QWZ2_BRAHW
          Length = 264

 Score = 39.5 bits (91), Expect = 0.071,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVI----ENLRKR 201
             EE  E   A    D   +  E  D++ H++    +   +   ++  V     E L +R
Sbjct: 35  FLEEAYEVVEAINNRDYENIKEELGDVLLHVVFFSELAKDENKFNIDDVCKNISEKLIRR 94

Query: 202 H 202
           H
Sbjct: 95  H 95


>UniRef50_A2BTR6 MazG family protein n=7 Tax=Prochlorococcus marinus
           RepID=A2BTR6_PROMS
          Length = 284

 Score = 39.5 bits (91), Expect = 0.081,   Method: Composition-based stats.
 Identities = 13/53 (24%), Positives = 24/53 (45%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
             I +K+ EE  E   A    +  E+ NE  D+ + LL L     ++  + ++
Sbjct: 184 DEIFKKLEEEINELKEAIKSKNDSEIKNEFGDIYFTLLNLSNFLKINPESALQ 236


>UniRef50_A8ATT3 Gp45 n=1 Tax=Listeria phage P35 RepID=A8ATT3_9CAUD
          Length = 104

 Score = 39.1 bits (90), Expect = 0.083,   Method: Composition-based stats.
 Identities = 15/50 (30%), Positives = 21/50 (42%), Gaps = 1/50 (2%)

Query: 138 LYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
           L     +    KV EE  ET  A    D+  L  E  D ++  +V+L  Q
Sbjct: 21  LDTKDPRNQMLKVVEEVGETTQALVKGDKDHLPEEIGD-IFVTIVILAQQ 69


>UniRef50_B2UPD1 MazG family protein n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UPD1_AKKM8
          Length = 269

 Score = 39.1 bits (90), Expect = 0.084,   Method: Composition-based stats.
 Identities = 13/68 (19%), Positives = 23/68 (33%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIEN- 197
              +   + EE  E       +D  +L  E  D++    +H  +  +    D   V    
Sbjct: 40  HHSLISNMIEEAYEVVDTIQRNDWTQLREELGDVLLQVVFHAEIAQEAGRFDFNDVAAEV 99

Query: 198 ---LRKRH 202
              L +RH
Sbjct: 100 SEKLVRRH 107


>UniRef50_Q30YJ6 MazG family protein n=6 Tax=Desulfovibrionales RepID=Q30YJ6_DESDG
          Length = 268

 Score = 39.1 bits (90), Expect = 0.086,   Method: Composition-based stats.
 Identities = 14/72 (19%), Positives = 24/72 (33%), Gaps = 16/72 (22%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ--------DQGLDLT-- 192
            + +   V EE  E   A    +  ++  E  D+M+    L+           G  L   
Sbjct: 34  PESLCDYVLEEAFELVDAIRSGNAADVREELGDVMF----LMAFIGRLYQDRAGFSLEDA 89

Query: 193 --TVIENLRKRH 202
              V   + +RH
Sbjct: 90  VADVAAKMVRRH 101


>UniRef50_C0Q9D5 Tetrapyrrole methylase family protein (MazG family protein) n=1
           Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0Q9D5_DESAH
          Length = 273

 Score = 39.1 bits (90), Expect = 0.087,   Method: Composition-based stats.
 Identities = 13/51 (25%), Positives = 24/51 (47%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           + +KV EE  E   A    D+ E+  E  D+++ L  + +  G+   T + 
Sbjct: 176 VIEKVEEEWKEFTQALATGDKDEIAMEFGDILFTLSNVARFAGIHPETALA 226


>UniRef50_C0WDQ0 Putative uncharacterized protein n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WDQ0_9FIRM
          Length = 264

 Score = 39.1 bits (90), Expect = 0.093,   Method: Composition-based stats.
 Identities = 14/54 (25%), Positives = 22/54 (40%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI 195
                 +KV EE  E   A    ++  +  E  DL + L V  +  GL+  T +
Sbjct: 166 DADCAYEKVKEEENELKEAILSKNKDHVEEELGDLFFALSVYARKLGLEPETAL 219


>UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HVH1_9BACT
          Length = 292

 Score = 39.1 bits (90), Expect = 0.095,   Method: Composition-based stats.
 Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 1/58 (1%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +  KV EE  E   AA       LT E  D+++ +    +  G+     +    K+ +
Sbjct: 194 VLDKVEEECAE-IRAALSEGSARLTEEIGDMLFAMAQFARLSGIRPEEALSEANKKFK 250


>UniRef50_C1TQS2 MazG family protein n=3 Tax=Synergistaceae RepID=C1TQS2_9BACT
          Length = 275

 Score = 39.1 bits (90), Expect = 0.096,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----NLRKR 201
           + EE  E   A    D   +  E+ DL+    +  ++  +     L  ++      L +R
Sbjct: 40  IIEEAYELVDAVDNGDIAGICEESGDLLLQVVFIGVIAEESGDFSLADIVRSISDKLIRR 99

Query: 202 H 202
           H
Sbjct: 100 H 100


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero...   264   1e-69
UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri...   262   7e-69
UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac...   261   1e-68
UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ...   260   2e-68
UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob...   258   1e-67
UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon...   257   1e-67
UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI...   256   3e-67
UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell...   254   1e-66
UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri...   254   2e-66
UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm...   253   3e-66
UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   251   1e-65
UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   250   2e-65
UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific...   247   1e-64
UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   247   3e-64
UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi...   244   2e-63
UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   243   3e-63
UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   242   6e-63
UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell...   241   9e-63
UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact...   241   1e-62
UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana...   241   1e-62
UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   241   1e-62
UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba...   240   2e-62
UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac...   240   3e-62
UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   238   7e-62
UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul...   237   2e-61
UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p...   234   2e-60
UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm...   233   3e-60
UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   232   7e-60
UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ...   232   8e-60
UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman...   231   1e-59
UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy...   231   1e-59
UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   230   3e-59
UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote...   229   4e-59
UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His...   229   4e-59
UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   229   5e-59
UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His...   229   5e-59
UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy...   228   8e-59
UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   228   1e-58
UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5     227   1e-58
UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI...   227   2e-58
UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos...   226   3e-58
UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte...   226   3e-58
UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   225   6e-58
UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep...   225   8e-58
UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   224   2e-57
UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI...   223   2e-57
UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero...   222   5e-57
UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   222   8e-57
UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos...   221   1e-56
UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   219   3e-56
UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ...   217   3e-55
UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   216   5e-55
UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   211   9e-54
UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A...   205   5e-52
UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper...   205   7e-52
UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel...   199   5e-50
UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI...   193   4e-48
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   192   7e-48
UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T...   187   3e-46
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   184   1e-45
UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros...   184   2e-45
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   183   3e-45
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   178   7e-44
UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz...   178   8e-44
UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor...   176   4e-43
UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu...   172   7e-42
UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon...   169   6e-41
UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu...   168   1e-40
UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   167   2e-40
UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter...   166   3e-40
UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte...   166   3e-40
UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   165   6e-40
UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin...   165   6e-40
UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   165   7e-40
UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo...   165   8e-40
UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   165   1e-39
UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin...   164   1e-39
UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   163   2e-39
UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap...   163   3e-39
UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m...   163   3e-39
UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell...   163   3e-39
UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote...   163   4e-39
UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap...   162   5e-39
UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte...   161   1e-38
UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte...   161   1e-38
UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote...   161   1e-38
UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote...   160   3e-38
UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   160   4e-38
UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar...   160   4e-38
UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein...   159   4e-38
UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   159   4e-38
UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm...   159   4e-38
UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   159   5e-38
UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   159   6e-38
UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch...   158   8e-38
UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein...   158   9e-38
UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   158   9e-38
UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   158   1e-37
UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob...   158   1e-37
UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo...   158   1e-37
UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul...   157   2e-37
UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob...   157   2e-37
UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote...   157   2e-37
UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte...   156   3e-37
UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin...   156   4e-37
UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero...   156   5e-37
UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax...   156   6e-37
UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact...   155   1e-36
UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon...   155   1e-36
UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   154   1e-36
UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob...   153   3e-36
UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax...   153   3e-36
UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan...   153   4e-36
UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte...   152   6e-36
UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu...   151   9e-36
UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote...   151   1e-35
UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   151   1e-35
UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p...   151   2e-35
UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin...   151   2e-35
UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro...   150   3e-35
UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob...   150   3e-35
UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ...   150   4e-35
UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=...   149   4e-35
UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu...   149   5e-35
UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   149   6e-35
UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo...   148   1e-34
UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr...   148   1e-34
UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero...   146   4e-34
UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom...   146   5e-34
UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   145   6e-34
UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo...   145   1e-33
UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   144   2e-33
UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl...   142   7e-33
UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo...   140   2e-32
UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax...   140   4e-32
UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha...   134   2e-30
UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico...   133   3e-30
UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros...   131   2e-29
UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing...   129   6e-29
UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr...   126   4e-28
UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo...   124   2e-27
UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos...   123   3e-27
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   117   2e-25
UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos...   117   3e-25
UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   116   5e-25
UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid...   116   6e-25
UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu...   112   9e-24
UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact...   111   1e-23
UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact...   111   2e-23
UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=...   109   4e-23
UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm...   109   6e-23
UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C...   108   1e-22
UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost...   108   2e-22
UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh...   106   4e-22
UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph...   106   4e-22
UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap...   106   5e-22
UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk...   105   1e-21
UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell...   105   1e-21
UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta...   105   1e-21
UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo...   104   1e-21
UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi...   104   2e-21
UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph...   104   2e-21
UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto...   103   3e-21
UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri...   103   3e-21
UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins...   103   4e-21
UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha...   103   4e-21
UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom...   103   4e-21
UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto...   103   5e-21
UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...   103   5e-21
UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot...   102   7e-21
UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl...   102   7e-21
UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra...   102   7e-21
UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot...   102   9e-21
UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul...   102   9e-21
UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   101   2e-20
UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote...   101   2e-20
UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot...   101   2e-20
UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph...   100   3e-20
UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...   100   3e-20
UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther...   100   4e-20
UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi...    99   4e-20
UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...    99   8e-20
UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu...    98   2e-19
UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph...    97   3e-19
UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha...    96   5e-19
UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    96   5e-19
UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br...    96   9e-19
UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo...    96   9e-19
UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu...    96   9e-19
UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    95   1e-18
UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    93   4e-18
UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov...    93   5e-18
UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob...    93   6e-18
UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin...    92   1e-17
UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury...    91   2e-17
UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom...    90   6e-17
UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo...    89   1e-16
UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre...    87   3e-16
UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re...    87   3e-16
UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost...    86   5e-16
UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti...    86   5e-16
UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact...    85   2e-15
UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba...    84   3e-15
UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta...    83   8e-15
UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p...    81   2e-14
UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    81   3e-14
UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob...    80   5e-14
UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac...    79   7e-14
UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha...    79   1e-13
UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo...    79   1e-13
UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc...    78   1e-13
UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus...    78   1e-13
UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax...    76   5e-13
UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    76   6e-13
UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo...    75   1e-12
UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth...    75   2e-12
UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp....    63   8e-09
UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip...    62   1e-08
UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog...    61   2e-08
UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph...    61   3e-08
UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil...    61   3e-08
UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640...    61   3e-08
UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma...    60   4e-08
UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID...    60   7e-08
UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm...    59   9e-08
UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip...    59   1e-07
UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus...    59   1e-07
UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1...    58   1e-07
UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R...    58   2e-07
UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas...    58   2e-07
UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ...    58   2e-07
UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax...    58   2e-07
UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase...    58   3e-07
UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=...    56   9e-07
UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID...    54   2e-06
UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact...    53   6e-06
UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ...    53   7e-06
UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=A...    52   1e-05
UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax...    52   1e-05
UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frank...    51   2e-05
UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC...    50   5e-05
UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm...    50   5e-05

Sequences not found previously or not previously below threshold:

UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC...    57   3e-07
UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB...    55   1e-06
UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepI...    55   1e-06
UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii K...    55   2e-06
UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX Re...    54   2e-06
UniRef50_B3DW98 Predicted pyrophosphatase n=1 Tax=Methylacidiphi...    54   3e-06
UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Str...    54   4e-06
UniRef50_Q0S4J7 Putative uncharacterized protein n=4 Tax=Nocardi...    53   7e-06
UniRef50_Q0A8N1 MazG family protein n=4 Tax=Proteobacteria RepID...    53   7e-06
UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str...    53   8e-06
UniRef50_A8L147 MazG family protein n=4 Tax=Frankia RepID=A8L147...    53   9e-06
UniRef50_B8HTG9 MazG family protein n=2 Tax=Chroococcales RepID=...    52   1e-05
UniRef50_A9FF91 Putative uncharacterized protein mazG n=1 Tax=So...    52   1e-05
UniRef50_C8WFT9 MazG family protein n=3 Tax=Zymomonas mobilis Re...    52   1e-05
UniRef50_C6QD16 MazG family protein n=6 Tax=Proteobacteria RepID...    52   1e-05
UniRef50_C9XSA1 Putative bifunctional protein [include tetrapyrr...    52   1e-05
UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermo...    52   1e-05
UniRef50_B0CCR5 MazG family protein n=8 Tax=Cyanobacteria RepID=...    52   1e-05
UniRef50_C0QR38 MazG family protein n=4 Tax=Hydrogenothermaceae ...    52   1e-05
UniRef50_Q04VW6 Pyrophosphatase n=6 Tax=Leptospira RepID=Q04VW6_...    52   1e-05
UniRef50_B5JET8 MazG family protein n=1 Tax=Verrucomicrobiae bac...    51   2e-05
UniRef50_Q7V9I6 Predicted pyrophosphatase n=1 Tax=Prochlorococcu...    51   2e-05
UniRef50_Q6G3M6 MazG protein n=1 Tax=Bartonella henselae RepID=Q...    51   2e-05
UniRef50_A2CDV8 MazG family protein n=11 Tax=Cyanobacteria RepID...    51   2e-05
UniRef50_Q3AVT5 MazG n=4 Tax=Cyanobacteria RepID=Q3AVT5_SYNS9          51   2e-05
UniRef50_C7MMP1 MazG family protein n=2 Tax=Coriobacteriaceae Re...    51   3e-05
UniRef50_A8ZVD0 MazG family protein n=1 Tax=Desulfococcus oleovo...    51   3e-05
UniRef50_A4J0R1 MazG family protein n=4 Tax=Clostridia RepID=A4J...    51   3e-05
UniRef50_B0SCK2 Pyrophosphatase n=2 Tax=Leptospira biflexa serov...    51   3e-05
UniRef50_Q3Z619 MazG family protein n=5 Tax=Dehalococcoides RepI...    50   4e-05
UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber D...    50   4e-05
UniRef50_B2TI15 MazG family protein n=5 Tax=Clostridium RepID=B2...    50   4e-05
UniRef50_B9XJR1 MazG family protein n=1 Tax=bacterium Ellin514 R...    50   4e-05
UniRef50_B5HJI9 Nucleoside triphosphate pyrophosphohydrolase n=2...    50   4e-05
UniRef50_B0K4Q4 MazG family protein n=10 Tax=Clostridia RepID=B0...    50   4e-05
UniRef50_B9CMC9 Tetrapyrrole methylase family protein, MazG fami...    50   5e-05
UniRef50_A6LPK0 MazG family protein n=10 Tax=Clostridia RepID=A6...    50   5e-05
UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus...    49   6e-05
UniRef50_Q1K0K7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Des...    49   6e-05
UniRef50_Q28PV1 MazG family protein n=8 Tax=Bacteria RepID=Q28PV...    49   6e-05
UniRef50_Q7D8Z6 Transcriptional regulator, MazG family n=3 Tax=M...    49   7e-05
UniRef50_C1TQS2 MazG family protein n=3 Tax=Synergistaceae RepID...    49   7e-05
UniRef50_Q2JT55 MazG family protein n=4 Tax=Bacteria RepID=Q2JT5...    49   7e-05
UniRef50_D2LXK4 MazG family protein n=2 Tax=Bacillus RepID=D2LXK...    49   7e-05
UniRef50_B2UPD1 MazG family protein n=1 Tax=Akkermansia muciniph...    49   7e-05
UniRef50_P37556 Uncharacterized protein yabN n=95 Tax=Bacillacea...    49   1e-04
UniRef50_B1C9L0 Putative uncharacterized protein n=1 Tax=Anaerof...    49   1e-04
UniRef50_B0TBB1 Mazg family protein n=4 Tax=Bacteria RepID=B0TBB...    49   1e-04
UniRef50_D2PPA8 MazG family protein n=2 Tax=Actinomycetales RepI...    49   1e-04
UniRef50_B8KRH4 MazG family protein n=1 Tax=gamma proteobacteriu...    48   1e-04
UniRef50_B4RXM6 MazG protein n=3 Tax=Proteobacteria RepID=B4RXM6...    48   1e-04
UniRef50_B1XI42 MazG family protein n=22 Tax=Cyanobacteria RepID...    48   2e-04
UniRef50_D1PLC7 MazG protein n=3 Tax=Ruminococcaceae RepID=D1PLC...    48   2e-04
UniRef50_C0WDQ0 Putative uncharacterized protein n=1 Tax=Acidami...    48   2e-04
UniRef50_C1F8P3 MazG family protein n=1 Tax=Acidobacterium capsu...    48   2e-04
UniRef50_Q1IPL4 MazG family protein n=1 Tax=Candidatus Koribacte...    48   2e-04
UniRef50_B8D010 MazG family protein n=3 Tax=Bacteria RepID=B8D01...    48   2e-04
UniRef50_C9LLX3 MazG protein n=1 Tax=Dialister invisus DSM 15470...    48   3e-04
UniRef50_A4EC03 Putative uncharacterized protein n=1 Tax=Collins...    48   3e-04
UniRef50_C0QWZ2 Nucleoside triphosphate pyrophosphohydrolase n=2...    48   3e-04
UniRef50_C8W8X4 MazG family protein n=2 Tax=Coriobacteriaceae Re...    48   3e-04
UniRef50_A7VWY5 Putative uncharacterized protein n=4 Tax=Clostri...    48   3e-04
UniRef50_Q0B0R5 MazG protein n=1 Tax=Syntrophomonas wolfei subsp...    48   3e-04
UniRef50_Q8NRS5 Predicted pyrophosphatase n=4 Tax=Corynebacteriu...    47   4e-04
UniRef50_D0L751 MazG nucleotide pyrophosphohydrolase n=1 Tax=Gor...    47   4e-04
UniRef50_Q2LVG8 MazG-like domain protein n=1 Tax=Syntrophus acid...    47   4e-04
UniRef50_A0QBX2 Transcriptional regulator, MazG family protein n...    47   4e-04
UniRef50_B0VJQ1 Nucleoside triphosphate pyrophosphohydrolase n=1...    47   4e-04
UniRef50_B6GA15 Putative uncharacterized protein n=2 Tax=Collins...    47   5e-04
UniRef50_C7QJ07 MazG family protein n=7 Tax=Actinomycetales RepI...    47   5e-04
UniRef50_Q6AK03 Putative uncharacterized protein n=1 Tax=Desulfo...    47   5e-04
UniRef50_B2GM14 Putative uncharacterized protein n=1 Tax=Kocuria...    46   5e-04
UniRef50_C7R009 MazG family protein n=1 Tax=Jonesia denitrifican...    46   5e-04
UniRef50_Q30YJ6 MazG family protein n=6 Tax=Desulfovibrionales R...    46   5e-04
UniRef50_D1W9A9 MazG family protein n=5 Tax=Prevotella RepID=D1W...    46   6e-04
UniRef50_D1N5T1 MazG family protein n=1 Tax=Victivallis vadensis...    46   6e-04
UniRef50_A9KR53 MazG family protein n=1 Tax=Clostridium phytofer...    46   6e-04
UniRef50_D1YB63 MazG family protein n=2 Tax=Propionibacterium ac...    46   6e-04
UniRef50_B1YGQ0 MazG family protein n=5 Tax=Bacillales RepID=B1Y...    46   6e-04
UniRef50_C1XVA0 MazG family protein n=2 Tax=Deinococci RepID=C1X...    46   6e-04
UniRef50_UPI0001C36472 MazG family protein n=1 Tax=Clostridium h...    46   7e-04
UniRef50_A1SF64 MazG nucleotide pyrophosphohydrolase n=1 Tax=Noc...    46   7e-04
UniRef50_B1GYU5 Putative nucleotide pyrophosphohydrolase MazG n=...    46   7e-04
UniRef50_P0AEY4 Protein mazG n=179 Tax=Proteobacteria RepID=MAZG...    46   7e-04
UniRef50_P44723 Protein mazG homolog n=57 Tax=Gammaproteobacteri...    46   7e-04
UniRef50_C8WQS0 MazG family protein n=2 Tax=Alicyclobacillus aci...    46   7e-04
UniRef50_B1J1L8 MazG family protein n=14 Tax=Bacteria RepID=B1J1...    46   8e-04
UniRef50_B5YFB4 MazG n=2 Tax=Dictyoglomus RepID=B5YFB4_DICT6           46   8e-04
UniRef50_B0MPG5 Putative uncharacterized protein n=1 Tax=Eubacte...    46   0.001
UniRef50_A8UAP0 Putative uncharacterized protein n=1 Tax=Carnoba...    46   0.001
UniRef50_C0AEE9 MazG family protein (Fragment) n=1 Tax=Opitutace...    46   0.001
UniRef50_A6G509 MazG family protein n=1 Tax=Plesiocystis pacific...    46   0.001
UniRef50_D1A7M2 MazG family protein n=8 Tax=Actinomycetales RepI...    46   0.001
UniRef50_D0LI16 MazG family protein n=1 Tax=Haliangium ochraceum...    46   0.001
UniRef50_Q1J066 MazG family protein n=5 Tax=Deinococci RepID=Q1J...    46   0.001
UniRef50_Q1NJI5 MazG nucleotide pyrophosphohydrolase n=2 Tax=del...    45   0.001
UniRef50_C5VBE9 Nucleoside triphosphate pyrophosphohydrolase n=2...    45   0.001
UniRef50_C7RAH4 MazG family protein n=1 Tax=Kangiella koreensis ...    45   0.001
UniRef50_Q6MDA8 Putative uncharacterized protein n=1 Tax=Candida...    45   0.002
UniRef50_A2BTR6 MazG family protein n=7 Tax=Prochlorococcus mari...    45   0.002
UniRef50_UPI0001C317DB MazG family protein n=1 Tax=Conexibacter ...    45   0.002
UniRef50_C8WJX9 MazG family protein n=1 Tax=Eggerthella lenta DS...    44   0.002
UniRef50_C1A8D0 Putative nucleoside triphosphate pyrophosphohydr...    44   0.002
UniRef50_A4A3U0 MazG nucleotide pyrophosphohydrolase family prot...    44   0.002
UniRef50_A3WPS6 Predicted pyrophosphatase MazG n=2 Tax=Idiomarin...    44   0.002
UniRef50_D2S938 MazG family protein n=1 Tax=Geodermatophilus obs...    44   0.002
UniRef50_UPI000197392B MazG family protein n=1 Tax=Clostridium s...    44   0.002
UniRef50_Q6I858 Predicted MazG-family transcriptional regulator ...    44   0.003
UniRef50_P33653 Uncharacterized 26.1 kDa protein in blaB 3'regio...    44   0.003
UniRef50_C1YI03 MazG family protein n=1 Tax=Nocardiopsis dassonv...    44   0.003
UniRef50_Q3JCR4 Tetrapyrrole methylase family protein / MazG fam...    44   0.003
UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY...    44   0.003
UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus k...    44   0.003
UniRef50_Q5HIH0 Tetrapyrrole methylase family protein n=63 Tax=S...    44   0.003
UniRef50_Q3B1B2 MazG n=12 Tax=Chlorobiaceae RepID=Q3B1B2_PELLD         44   0.004
UniRef50_D2NPA3 Predicted pyrophosphatase n=2 Tax=Rothia mucilag...    44   0.004
UniRef50_Q2SL25 Predicted pyrophosphatase n=20 Tax=Proteobacteri...    44   0.004
UniRef50_A9AYB5 MazG family protein n=1 Tax=Herpetosiphon aurant...    43   0.004
UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG fami...    43   0.004
UniRef50_A0LK91 MazG family protein n=1 Tax=Syntrophobacter fuma...    43   0.005
UniRef50_Q65VQ2 MazG protein n=1 Tax=Mannheimia succiniciproduce...    43   0.005
UniRef50_A3YTK8 MazG n=1 Tax=Synechococcus sp. WH 5701 RepID=A3Y...    43   0.005
UniRef50_B7H015 MazG family protein n=18 Tax=Acinetobacter RepID...    43   0.006
UniRef50_B7JWE8 MazG nucleotide pyrophosphohydrolase n=2 Tax=Cya...    43   0.006
UniRef50_A5CTB1 Putative pyrophosphatase n=4 Tax=Actinobacteria ...    43   0.006
UniRef50_C6CRL2 MazG family protein n=6 Tax=Firmicutes RepID=C6C...    43   0.006
UniRef50_B1ZW78 MazG family protein n=1 Tax=Opitutus terrae PB90...    43   0.006
UniRef50_C7JCN1 Nucleotide pyrophosphohydrolase MazG n=8 Tax=Ace...    43   0.006
UniRef50_Q6MMY5 Tetrapyrrole methylase family protein/MazG famil...    43   0.006
UniRef50_B5Y801 MazG family protein n=1 Tax=Coprothermobacter pr...    43   0.007
UniRef50_A8ATT3 Gp45 n=1 Tax=Listeria phage P35 RepID=A8ATT3_9CAUD     43   0.007
UniRef50_B8FGV8 MazG family protein n=1 Tax=Desulfatibacillum al...    43   0.007
UniRef50_D1R6W2 Putative uncharacterized protein n=1 Tax=Parachl...    43   0.009
UniRef50_C3JX00 Nucleoside triphosphate pyrophosphohydrolase n=1...    42   0.012
UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax...    42   0.012
UniRef50_A5ZV93 Putative uncharacterized protein n=1 Tax=Ruminoc...    42   0.012
UniRef50_C0Q9D5 Tetrapyrrole methylase family protein (MazG fami...    42   0.013
UniRef50_A6TJN3 MazG family protein n=33 Tax=Bacteria RepID=A6TJ...    42   0.013
UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferro...    42   0.016
UniRef50_Q027H8 MazG family protein n=1 Tax=Candidatus Solibacte...    42   0.016
UniRef50_Q1QX16 MazG family protein n=12 Tax=Proteobacteria RepI...    41   0.017
UniRef50_C4B7S4 Putative MazG family protein n=1 Tax=Desulfotign...    41   0.017
UniRef50_D2RFM2 MazG nucleotide pyrophosphohydrolase n=3 Tax=Eur...    41   0.017
UniRef50_C7M0K4 MazG nucleotide pyrophosphohydrolase n=1 Tax=Aci...    41   0.019
UniRef50_C1ZK38 MazG family protein n=1 Tax=Planctomyces limnoph...    41   0.019
UniRef50_A9WKS6 MazG n=1 Tax=Renibacterium salmoninarum ATCC 332...    41   0.021
UniRef50_D2RLM3 MazG family protein n=1 Tax=Acidaminococcus ferm...    41   0.023
UniRef50_A8LHV5 MazG family protein n=9 Tax=Proteobacteria RepID...    41   0.029
UniRef50_C2CLU6 Nucleoside triphosphate pyrophosphohydrolase n=8...    41   0.034
UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Glucona...    41   0.034
UniRef50_A8V300 Putative uncharacterized protein (Fragment) n=1 ...    41   0.035
UniRef50_A6C1Y3 MazG family protein n=1 Tax=Planctomyces maris D...    40   0.038
UniRef50_B8DJD8 MazG family protein n=8 Tax=Desulfovibrionales R...    40   0.038
UniRef50_C8QYT7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Des...    40   0.038
UniRef50_C7RKB9 MazG nucleotide pyrophosphohydrolase n=1 Tax=Can...    40   0.044
UniRef50_C5ZZZ8 Beta-lactamase regulatory-like protein, mazg pro...    40   0.046
UniRef50_D1PFK2 MazG family protein n=3 Tax=Prevotella RepID=D1P...    40   0.056
UniRef50_A4X3B3 MazG nucleotide pyrophosphohydrolase n=4 Tax=Act...    40   0.061
UniRef50_B8G6I9 MazG family protein n=3 Tax=Chloroflexus RepID=B...    39   0.071
UniRef50_C2AVJ2 Protein with tetrapyrrole methyltransferase and ...    39   0.072
UniRef50_UPI000169915B nucleoside triphosphate pyrophosphohydrol...    39   0.073
UniRef50_A2BIS9 Mazg nucleotide pyrophosphohydrolase, chain A-co...    39   0.073
UniRef50_C8PQ63 MazG family protein n=1 Tax=Treponema vincentii ...    39   0.079
UniRef50_A0JU20 MazG family protein n=3 Tax=Arthrobacter RepID=A...    39   0.093

>UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C4Y5_SPHTD
          Length = 228

 Score =  264 bits (675), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 86/205 (41%), Positives = 121/205 (59%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGE
Sbjct: 14  VDAVRFD-ERGLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGE 72

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQ 117
           TSGN   VV I PDCD D LLV   P GPTCH GT +CF                  + +
Sbjct: 73  TSGNVHEVVEIRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDE 132

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           + +++AER++   E SYT  L  +G  +I +K+GEE  E  +AA   D   L NEA+DL+
Sbjct: 133 VARVVAERRAHPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLI 192

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLL+   +    V   LR R 
Sbjct: 193 YHLLVLLEASDVPTERVWAVLRTRR 217


>UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria
           RepID=C6PCK8_CLOTS
          Length = 228

 Score =  262 bits (669), Expect = 7e-69,   Method: Composition-based stats.
 Identities = 80/203 (39%), Positives = 118/203 (58%), Gaps = 9/203 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             +L ++   GL+P IVQ   + EVLM+ YMN E+L+K+LE+ +  FFSR++Q LW KGE
Sbjct: 9   IDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKGE 67

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD--------TAHQWLFLYQL 118
           TSGN  ++ +I  DCD DTLLV   P GP CH G +SCF             +   L  L
Sbjct: 68  TSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSNL 127

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + +  RK      SYT  L+  G  +I +K+GEE  E  +A+    + E+  E +D +Y
Sbjct: 128 YRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYIY 187

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           HL+VL+ ++G++L  V + + KR
Sbjct: 188 HLMVLMVEKGINLNDVYKEISKR 210


>UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria
           RepID=HIS2_VIBVY
          Length = 211

 Score =  261 bits (667), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 129/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
                   ++WEK DGL+P IVQ   S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL
Sbjct: 7   EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---GDTAHQWLFLYQL 118
           WTKGETSGN L +V+++ DCDNDTLLV  NPIGPTCH GT++C+        Q ++L+QL
Sbjct: 67  WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT  D+ EL  E++DL+Y
Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLLVLLQDQGL +  VI  L++RH+
Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211


>UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT
          Length = 215

 Score =  260 bits (665), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 98/196 (50%), Positives = 135/196 (68%), Gaps = 2/196 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   +  VLMLGYMN EA  KT+E+ KVTF+SR++  LWTKGETS
Sbjct: 2   QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA--HQWLFLYQLEQLLAERK 126
           GN+L++VSI  DCDNDTLLV  +P GPTCH GT +C+G+T   +  LFL +L+  +  R 
Sbjct: 62  GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P+ SYT  L+  G ++IAQKVGEE VET + A   +   L  EASD++YHL+VLL  
Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181

Query: 187 QGLDLTTVIENLRKRH 202
           +GL +  +   L +RH
Sbjct: 182 KGLHIEDLARELARRH 197


>UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria
           RepID=B5EQF3_ACIF5
          Length = 230

 Score =  258 bits (659), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 80/209 (38%), Positives = 111/209 (53%), Gaps = 12/209 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W   DGL+P I Q A SG VLML +MN +AL  TL  G  T++SR++Q LW K
Sbjct: 10  AILAAVRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ---- 120
           GETSG+  ++V +  DCD DTLL+     GP CH G  +CF                   
Sbjct: 69  GETSGHIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGS 128

Query: 121 -------LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
                   L  R++ADP  SY A+L   G  RI +KVGEE  E  +A   H+   +  EA
Sbjct: 129 ILDSLQVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEA 188

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL+V L+++ L +  V+  L +R 
Sbjct: 189 ADLVFHLMVALEERDLHIDDVLGELARRE 217


>UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae
           RepID=C4V2J2_9FIRM
          Length = 235

 Score =  257 bits (658), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 79/220 (35%), Positives = 116/220 (52%), Gaps = 22/220 (10%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  +    + D     GL+P IVQ   + +VLML YMN E+L+KT+E+G   ++SR++Q+
Sbjct: 2   MNVDMSMIQFD---DRGLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQK 57

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105
           LW KGETSGN   +  I+ DCD DT+L+     G  CH GT SCF               
Sbjct: 58  LWKKGETSGNVQRIKEISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIP 117

Query: 106 ---GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
               +       L  L Q++  R+    E SYT  L+  G  +I +K+GEE  ET +A+ 
Sbjct: 118 LIEKEEHPLTEVLASLYQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASK 177

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + R ++  E  DL YH LVLL    +    ++E L++R+
Sbjct: 178 NNIREDVLYEMGDLWYHCLVLLAYHNMTPEDLLEELKRRN 217


>UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria
           RepID=Q2JWX9_SYNJA
          Length = 231

 Score =  256 bits (655), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 78/205 (38%), Positives = 108/205 (52%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L +    GL+P IVQ  + G VLM+ +MN E+L KTLE+G+  F+SR++Q LW KGE
Sbjct: 25  LDNLSY-NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGE 83

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGD--------TAHQWLFLYQ 117
           TSG+   V  I  DCD+D L++L   +G   CH G  SCF                 L Q
Sbjct: 84  TSGHVQWVKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQ 143

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           +  ++  R++     SYT+ L A G   I +K+GEE  E  +AA   D+  L  E +DL 
Sbjct: 144 VFAVVKARQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLW 203

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YH LV L    +D+  V   L+ R 
Sbjct: 204 YHCLVALAHHQVDIRDVYRQLQARR 228


>UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms
           RepID=HIS2_SYNPX
          Length = 222

 Score =  254 bits (649), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 71/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L+     +L +    GL+P I Q  + G VLM+ +MN E++ +TL SG+  ++SR++Q L
Sbjct: 4   LSPAFIDQLRF-NEAGLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDT------------ 108
           W KG TSG+   + SI  DCD D LL+     G   CH G  SCF +             
Sbjct: 63  WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
           +       +L +++  R+    E SYT KL   G  +I +K+GEE  E  +A    +  E
Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  EA+D+++H+ V L   G+    V E L  R 
Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216


>UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria
           RepID=C6J1M1_9BACL
          Length = 231

 Score =  254 bits (649), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 92/213 (43%), Positives = 128/213 (60%), Gaps = 13/213 (6%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            E   + + W+   GL+P IVQ A S EVLML YMN E+L K++E+G+  F+SR++  LW
Sbjct: 15  IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------AH 110
            KG TSGN   + ++  DCD DTLLV     GP CH G  +CF  T              
Sbjct: 74  NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           ++  L +LEQL+AER +  PE +YT  L+  G  +I +KVGEE  E+ +AA   D  EL 
Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E SDL+YHLLVLL+++ L L  +++ L +RH+
Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226


>UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes
           RepID=HIS2_OCEIH
          Length = 215

 Score =  253 bits (646), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 84/207 (40%), Positives = 120/207 (57%), Gaps = 6/207 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M        L ++   GL+P IVQ   SG+VL L YMN +++ KT+E+ +  F+SR +Q 
Sbjct: 1   MTKSISIEHLQFD-EKGLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQE 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-----LFL 115
           LW KG TSGN   V  I+ DCD D +LVL +  GP CH G  SCF +  ++        +
Sbjct: 60  LWNKGATSGNKQTVKQISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQII 119

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            Q+   + ER     E +YT+ L+  G  +I +K+GEE  E  +AA   D+ ELT+E SD
Sbjct: 120 PQVSAKIKERHEHPVEGAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSD 179

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202
           L+YH LVL++ QG+ L  + + L KRH
Sbjct: 180 LLYHSLVLMEQQGVTLEDIKKELYKRH 206


>UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=A9B1U1_HERA2
          Length = 212

 Score =  251 bits (641), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 103/205 (50%), Positives = 127/205 (61%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             EL ++   GL+P +VQHA SGEVLM+GYMN EAL KT  SG VTF+SR++Q+LWTKGE
Sbjct: 1   MVELTYDS-QGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGE 59

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL---------YQ 117
           TSGN L  ++   DCDND LL+LA P GPTCH G+ SCF  T                 Q
Sbjct: 60  TSGNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQ 119

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + L ER+   P  SYT  L   G  +I +K+GEE  E  +AA   +  EL NEASDL+
Sbjct: 120 LFEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLI 179

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHL VLL +QG+    V   LR+RH
Sbjct: 180 YHLFVLLLNQGVSPEDVWFTLRERH 204


>UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=10 Tax=Bacteria
           RepID=C0QVS5_BRAHW
          Length = 220

 Score =  250 bits (639), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 115/205 (56%), Gaps = 6/205 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + + +  +L ++   GL+P IV    + EVL L YMN E+L+ +++  K  F+SR++Q L
Sbjct: 4   INQNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL-----Y 116
           W KGETSGN+ ++ SI  DCDND L++     GP CH G+ SCF +  +           
Sbjct: 63  WRKGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSID 122

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +L+  RK    E SYT  L+ SG  +I +KVGEE  E  + A      E   E SDL
Sbjct: 123 KLYKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDL 182

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           +YH LVL+ ++G+ +  +   L  R
Sbjct: 183 LYHSLVLMVEKGITINDIKNELASR 207


>UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae
           RepID=B4U8T9_HYDS0
          Length = 207

 Score =  247 bits (632), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 80/205 (39%), Positives = 116/205 (56%), Gaps = 9/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+PVI Q A SGE+ ML Y N EA+ KT+E+G   +FSR++  +W KGE
Sbjct: 3   IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFGDTA-------HQWLFLYQL 118
           TSG    V+ I  DCDNDTL+ +        CH G  +CF             +  L  L
Sbjct: 62  TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E+L+ +R S   E+SYT+KL   G  RI QKVGEE +E+ +A    D+ E+  E +DL+Y
Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           H+LV ++   +    V   L +RH+
Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206


>UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Legionella
           RepID=C6N0X1_9GAMM
          Length = 207

 Score =  247 bits (630), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 95/198 (47%), Positives = 131/198 (66%), Gaps = 1/198 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW+K +GL+P I+Q+A +G VLMLGYMN EAL  T+ +G++T +SR+++RLW KGE
Sbjct: 6   ISALDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGE 65

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQLLAER 125
           TSGN + V  I+ DCD+D+LL++  P GP CH G +SC+    H    F+  L +++ ER
Sbjct: 66  TSGNTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINER 125

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
                E SYTA+L ASG  R AQKVGEE VET +AA      E  NE +DL++HLLVLL+
Sbjct: 126 AETQAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLK 185

Query: 186 DQGLDLTTVIENLRKRHQ 203
              L    V++ L+ R +
Sbjct: 186 ASELSFYDVLQCLQDRDR 203


>UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3
           Tax=Clostridiales RepID=C4Z9Z2_EUBR3
          Length = 427

 Score =  244 bits (622), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%)

Query: 1   MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           +L +    +L W      +DG++PVIVQ   + +VLML YMN EA + T+ SG++T++SR
Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108
           ++  LWTKG TSG+   V S+  DCD DT+L   + +G  CH    +CF +         
Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            +    L  +  ++ +R     E SYT  +   G   I +K+G E  E  LAA   D  +
Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           L  E SD MYH ++L+  + +    +   L +R
Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427


>UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI
          Length = 244

 Score =  243 bits (620), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 85/218 (38%), Positives = 115/218 (52%), Gaps = 27/218 (12%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + W+   GL+P I Q ++S EVLML YMN EAL+ TL++G   +FSR+KQR+W KGE SG
Sbjct: 6   IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------------- 106
           N   V  I  DCD+D++L+  N  G  CH G  SCF                        
Sbjct: 65  NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124

Query: 107 ---DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
               + + +  L  L   L ERK+AD  TSYTA L+A GT  IA+K+ EE  E   A   
Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            D  E+  E +D+ YH+LV L  + +    + + L KR
Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222


>UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=1 Tax=Candidatus Poribacteria
           sp. WGA-A3 RepID=D2MIV8_9BACT
          Length = 234

 Score =  242 bits (618), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 113/205 (55%), Gaps = 14/205 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + ++   GL+P +VQ    G +LML YMN EALD+TL++G V F+SR++++LW KGETSG
Sbjct: 16  IQFD-ERGLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSG 74

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-------------LFLY 116
           ++L    +  DCD D LLV A P GPTCH    +CF                        
Sbjct: 75  HYLLCKRVFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFD 134

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +++ +RK+   E SY + L   G  RI +KV EE  E  LA     R E+ +E +DL
Sbjct: 135 RLYEMVLQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADL 194

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           ++H +V L    + +T + + L KR
Sbjct: 195 IFHSIVALGHCEIPMTAIQQELGKR 219


>UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms
           RepID=HIS2_THEP3
          Length = 216

 Score =  241 bits (616), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 78/215 (36%), Positives = 113/215 (52%), Gaps = 22/215 (10%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E   +EL ++   GL+PVI Q   + EVLM+ Y+    L K+LE+GKV +FSR++ +LW 
Sbjct: 2   ENILKELKFD-DRGLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLY------- 116
           KGETSG+F  + SI+ DCD DTLL+    +   CH G  SCF                  
Sbjct: 61  KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120

Query: 117 --------------QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
                         ++  ++ +R     E SYT  L+  G  +I +KVGEE  E  + A 
Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             D+ E+  E SDL+YHLLVL+ ++G+ L  + E 
Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215


>UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria
           RepID=HIS2_XANCP
          Length = 206

 Score =  241 bits (616), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 115/199 (57%), Positives = 135/199 (67%), Gaps = 2/199 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                LDW K DGL+PVIVQ A +  VLMLGYMN EAL  T   G+VTFFSR+KQRLWTK
Sbjct: 10  DALDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTK 69

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SGN L VV+I  DCD DTLLV A P GPTCH G +SCF        FL  L+ L+AE
Sbjct: 70  GESSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTA--PSQFLGSLDALIAE 127

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R+   P  SYT KL+  G +RIAQKVGEEGVETALA  V    EL  E++DL+YHL+VLL
Sbjct: 128 REHERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLL 187

Query: 185 QDQGLDLTTVIENLRKRHQ 203
           + +GL L   +  L  RH+
Sbjct: 188 RARGLGLGDAVALLESRHK 206


>UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius
           thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ
          Length = 211

 Score =  241 bits (615), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 87/203 (42%), Positives = 118/203 (58%), Gaps = 14/203 (6%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L 
Sbjct: 6   SQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLI 65

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ--------------LE 119
           V S+  DCD DTLL L  P GP CH G +SCF +   +                    L 
Sbjct: 66  VTSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLN 125

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           QL+ +R    P+ SY  KL   G  ++ +KVGEE  E   A    D+ E+ +E++DL++H
Sbjct: 126 QLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFH 185

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L+ L+   +DL+ V++ L  RH
Sbjct: 186 TLLALKYFQVDLSEVLQELHNRH 208


>UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius LAA1 RepID=B7DRK3_9BACL
          Length = 254

 Score =  241 bits (615), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 77/250 (30%), Positives = 115/250 (46%), Gaps = 49/250 (19%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           +  + +   + ++   GL+PV+ Q A +GEVLM+ Y + EAL +TL +G   ++SR+++ 
Sbjct: 4   VKGDVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRRE 63

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G  +CF               
Sbjct: 64  YWRKGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAAD 123

Query: 109 --------------------------------AHQWLFLYQLEQLLAERKSADPETSYTA 136
                                                 L +L  ++  R    P+ SYT 
Sbjct: 124 EGGAKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTT 183

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDL 191
            L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+  
Sbjct: 184 YLFTHGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHP 243

Query: 192 TTVIENLRKR 201
             V   L KR
Sbjct: 244 VDVWRTLEKR 253


>UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae
           RepID=C5SM65_9CAUL
          Length = 215

 Score =  240 bits (614), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 108/202 (53%), Positives = 134/202 (66%), Gaps = 1/202 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LT      LD+ K DGL+P IVQ A + +VLMLGYM+  AL +TL   +VTFFSR+K   
Sbjct: 11  LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQ 120
           W KGETSG+FLN+VS+  DCD D LLVLA P+GPTCH  T+SCFG        F+  L  
Sbjct: 71  WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ +R  A P  SYTA+L   G  +IAQKVGEEG+ETALA    D  EL NEA+DL+YHL
Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
            VLL  +   L  V++ LR+RH
Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212


>UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria
           RepID=HIS2_BLOFL
          Length = 213

 Score =  240 bits (612), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT ++ + L+W K  GL+P I+QH++SGEVLMLGYMN E++  T ++G VTFFSR+K R
Sbjct: 1   MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGE+SGN L +++  PDCD D+LL+L  P G TCHK T+SCF      + FL+QLE 
Sbjct: 61  LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120

Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +K+      + ++SYT+ LY SG +RIAQKVGEEG+ETALAA   +   L +EASD
Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+YHLLVLLQ + L+   VI+ LR R +
Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208


>UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WUY1_ALIAD
          Length = 256

 Score =  238 bits (608), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 79/255 (30%), Positives = 116/255 (45%), Gaps = 54/255 (21%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +   + ++   GL+PV+ Q A +G+VLML Y + EAL +TL +G   ++SR+++ 
Sbjct: 1   MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G   CF               
Sbjct: 61  YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120

Query: 109 -------------------------------------AHQWLFLYQLEQLLAERKSADPE 131
                                                A     L +L  ++  R    P+
Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186
            SYT  L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL + 
Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240

Query: 187 QGLDLTTVIENLRKR 201
            G+    V + L KR
Sbjct: 241 VGVQPADVWQVLEKR 255


>UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms
           RepID=C9RV77_GEOSY
          Length = 216

 Score =  237 bits (604), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 97/204 (47%), Positives = 128/204 (62%), Gaps = 10/204 (4%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
            ++ ++   GL+P IVQ A S EVL L YMN E+L+KTLE+G+  F+SR++Q LW KG T
Sbjct: 3   ADIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGAT 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF---------GDTAHQWLFLYQL 118
           SGN   VV I  DCD D LLVL  P GP CH G+ SCF            A ++  L +L
Sbjct: 62  SGNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNEL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQ++A+R +  PE SYT  L+  G  +I +KVGEE  E  +AA   +  EL  EA+DL+Y
Sbjct: 122 EQIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVLL++Q L L  V+  L +RH
Sbjct: 182 HLLVLLREQKLPLDAVLATLAERH 205


>UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1
           Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL
          Length = 207

 Score =  234 bits (596), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 99/197 (50%), Positives = 133/197 (67%), Gaps = 1/197 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             +D+EK +GL+PV+VQ A + +VL L YM+  ALD+T++SG+ TFFSR++   W KGET
Sbjct: 5   AAIDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGGRWRKGET 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLEQLLAERK 126
           SG+ L+VV I  DCD+D L++  NP+G  CH   +SCFG         + +LEQ +AER 
Sbjct: 65  SGDRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLEQTIAERA 124

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
           +ADP  S+TAKL   G KRIAQKVGEEGVETALA       EL +EA+DL+YHLLVLL  
Sbjct: 125 AADPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYHLLVLLHA 184

Query: 187 QGLDLTTVIENLRKRHQ 203
           + +    V++ L  R +
Sbjct: 185 RNMVFQDVLDVLASRAE 201


>UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga
           RepID=HIS2_THEMA
          Length = 197

 Score =  233 bits (595), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+VQ   +GEVLML Y N EAL+ T ++G   FFSR +Q++W KGETSGN + VV I
Sbjct: 4   LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63

Query: 78  APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQWL------FLYQLEQLLAERKSAD 129
             DCD+D  L + +       CH G  SCF    H++       F  +L +L+ +RK   
Sbjct: 64  RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT KL+  G  +IA+K GEE VE       +DR  L  E +D+MYHL VL+ D G+
Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183

Query: 190 DLTTVIENLRKRHQ 203
            +  V+  L KR +
Sbjct: 184 TVQDVMRELEKRRK 197


>UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=4 Tax=Flavobacteriales
           RepID=A4CLC1_9FLAO
          Length = 206

 Score =  232 bits (591), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 88/203 (43%), Positives = 124/203 (61%), Gaps = 6/203 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            + +D+EKT GL+P I+Q + +  VLMLGYM+ EAL+ T  SGKVTF+SR+K+RLWTKGE
Sbjct: 1   MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGNFL  V +  DCD D LL+ A P GP CH G+ +C+ +            + +   +
Sbjct: 61  SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120

Query: 127 SADPET------SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
               +T      SY A L   GT ++AQKVGEE VET + A   D     NE++DL++H 
Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           L+LLQ +G  +  +   L +RH+
Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203


>UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KI1_SYMTH
          Length = 210

 Score =  232 bits (591), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%)

Query: 27  VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86
            +G+VLM  YMN EAL  TLE+G   ++SR++Q LW KG TSG+   V  I  DCD D+L
Sbjct: 2   RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61

Query: 87  LVLANPIGPTCHKGTSSCFGD-----------------------TAHQWLFLYQLEQLLA 123
           L+L    G  CH+GT SCF                                L +L  +LA
Sbjct: 62  LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ER++     SYT++L+  G     +K+GEE  E  LA    DR  L  E +DL +H LV 
Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181

Query: 184 LQDQGLDLTTVIENLRKRH 202
           L DQGL    V + L  R 
Sbjct: 182 LVDQGLSPADVADQLASRR 200


>UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B858_THEAS
          Length = 205

 Score =  231 bits (589), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 94/201 (46%), Positives = 119/201 (59%), Gaps = 6/201 (2%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             ++W   D L+PV+VQ A SG VLML Y N EALD TL+ G+  FFSR++ RLW KGET
Sbjct: 3   DRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGET 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQLL 122
           SGN + V+ +  DCD D++L L    GP CH G  SCF            LFL++L +++
Sbjct: 62  SGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIV 121

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +R S   + SYT  L+  G  RIAQKVGEEGVE ALA    DR     EA+DL+YHL V
Sbjct: 122 DQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTV 181

Query: 183 LLQDQGLDLTTVIENLRKRHQ 203
            L+     L    + L  RHQ
Sbjct: 182 ALRRVDATLLDAEQVLMARHQ 202


>UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae
           RepID=D0LRT4_HALO1
          Length = 241

 Score =  231 bits (589), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 83/204 (40%), Positives = 115/204 (56%), Gaps = 16/204 (7%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L 
Sbjct: 21  NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG---------------DTAHQWLFLYQL 118
           V  +  DCD D ++V+A P GPTCH GT SCF                 +      L +L
Sbjct: 81  VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140

Query: 119 EQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           E ++A R+  AD E SYT  L   G  +I  K+ EE  E A      +R E+ +E +DL+
Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           +H++V L  + + L  V   L +R
Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224


>UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC
          Length = 251

 Score =  230 bits (586), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 80/233 (34%), Positives = 117/233 (50%), Gaps = 40/233 (17%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+PV++Q   +GEVLM+ YMN EAL+ T  +G   +FSR+K R+W KGE+S
Sbjct: 7   KIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKKGESS 65

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-----------------AHQ 111
           GN   V S   DCDNDTLL+     G  CH G  SCF +                    +
Sbjct: 66  GNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKISKPK 125

Query: 112 WLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF--- 167
           +  L +L  +  +RK +ADP+ SY AKLY  G     +K+ EE  E A A     R    
Sbjct: 126 YEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSRAKNY 185

Query: 168 ------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                             ++  E +DL++H++V L   G+    ++  L +R+
Sbjct: 186 RDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238


>UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria
           RepID=HIS2_HELHP
          Length = 231

 Score =  229 bits (585), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +   R++DWE+ + L+P IVQ   S ++LML Y + ++L+ +L++    +FSR+KQR+W 
Sbjct: 2   QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG----------------- 106
           KGE SG+  ++  +  DCDND+L+ +   +G  CH G  SCF                  
Sbjct: 61  KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120

Query: 107 --DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                  +  L  L  ++ +R+  + E SYTA L A G   I +K+ EE  E   A    
Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D   +  E +DL YH+LV L  + +    V++ LR+R
Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217


>UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT
          Length = 233

 Score =  229 bits (585), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 91/209 (43%), Positives = 128/209 (61%), Gaps = 8/209 (3%)

Query: 2   LTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTK 58
           L+E++   +  E   G   L+P +VQH  +G+VLMLGYM  EA + T  +GKVTFFSR++
Sbjct: 7   LSEKEILSVAEENAFGKADLIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSR 66

Query: 59  QRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL 113
           +++W KGETSGN L+V+ I  DCD DT+LVLA P+GPTCH G+ SCF           + 
Sbjct: 67  KKIWVKGETSGNGLDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFE 126

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
              +L+  + ERK+ DP+ SYTA L  S    + +K+ EE  E +LA  V  R    +E 
Sbjct: 127 VWSELQSTVRERKTGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEW 186

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL +H+ V L+  G+    V+E LRKR 
Sbjct: 187 ADLFFHIAVALEKTGVSWGEVMEILRKRQ 215


>UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Picrophilus torridus
           RepID=Q6KZD6_PICTO
          Length = 204

 Score =  229 bits (584), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 73/199 (36%), Positives = 111/199 (55%), Gaps = 13/199 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DG++PV+VQ   +G+VL L YM+  AL+ T+++G   ++SR+ +R+  KGE SGN   V
Sbjct: 9   NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFLYQLEQLLAE 124
           + I  DC++++LL+     GP CH G +SCF              +    L +LE L+ +
Sbjct: 69  MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R       SYT  L  SG + I +KVGEE +ET LA+    R  +  E +DL+YHL+V L
Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILAS---GRDRIVYETADLLYHLIVFL 185

Query: 185 QDQGLDLTTVIENLRKRHQ 203
               + L  V+  L +R +
Sbjct: 186 AFNNVSLFDVMNELNRRSK 204


>UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT
          Length = 230

 Score =  229 bits (584), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 85/206 (41%), Positives = 116/206 (56%), Gaps = 8/206 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +       +   + L PV+ Q    G+VLM+GYMN EA  +T+E G+VTFFSR+++RLWT
Sbjct: 2   DDAILRTLFPDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWT 61

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT--------AHQWLFL 115
           KGE+SG+FL +VS+  DCD DTLL L  P GPTCH GT SCF              +  L
Sbjct: 62  KGESSGHFLRLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETL 121

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             L   +A R+  DPETSY A+L +     + +K+ EE  ET  A    D     +E +D
Sbjct: 122 GDLAGTIALRRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMAD 181

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           L++HLLV ++        V+  L KR
Sbjct: 182 LLFHLLVAMERTRTPWEEVVGVLEKR 207


>UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP
           pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN
          Length = 215

 Score =  228 bits (582), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 83/204 (40%), Positives = 112/204 (54%), Gaps = 8/204 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             E+ ++  +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++  LW KG 
Sbjct: 3   IEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKGA 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ-------LE 119
            SGN   V+ +  DCD D +L    P GP CH G  +CF                   + 
Sbjct: 62  ISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKVY 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + L  R    PE SY  K++ +G  RI +K+GEE  E  +AA    R EL  EASDL++H
Sbjct: 122 RTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLFH 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           LL  L + GL    +   L +R+Q
Sbjct: 182 LLFTLTELGLSPQDLARVLWERNQ 205


>UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TLB5_9BACT
          Length = 188

 Score =  228 bits (581), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 88/187 (47%), Positives = 114/187 (60%), Gaps = 5/187 (2%)

Query: 22  IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81
           +VQ A SGEVLML Y N E++  TLE G++ F+SR+++ +W KG TSGN L + S+  DC
Sbjct: 2   VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61

Query: 82  DNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-----FLYQLEQLLAERKSADPETSYTA 136
           D D +L   +P+GP CH G  SCF    H        FL +L   L +R    PE SYTA
Sbjct: 62  DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +L A    R+AQK+GEEGVETALA    DR +   EA+DL+YHLLV L    L    +  
Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181

Query: 197 NLRKRHQ 203
            L+KRH+
Sbjct: 182 ELKKRHK 188


>UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5
          Length = 229

 Score =  227 bits (580), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 79/199 (39%), Positives = 105/199 (52%), Gaps = 15/199 (7%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQ  ++G+V ML YM  E+L +TLE+G+ TFFSR++  LW KG TSGN L V S+
Sbjct: 10  LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL--------------- 122
             DCD D LL+LA P GPTCH G++SCF                                
Sbjct: 70  HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
             RK++    SYT KL   G   I  K+ EE  E A A        + +EA+D++YHLLV
Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L  +G+ L  V+  L  R
Sbjct: 190 GLASRGVPLRAVLSALASR 208


>UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3
           Tax=Chloroflexi RepID=B9KXC5_THERP
          Length = 218

 Score =  227 bits (578), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 82/205 (40%), Positives = 117/205 (57%), Gaps = 9/205 (4%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
               + +   DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW KG
Sbjct: 9   LLGAIRF-GADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMKG 67

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE- 124
           ETSG+ L +V +  DCD D LL   +P GPTCH G  SCF            +   + + 
Sbjct: 68  ETSGHVLELVELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILDE 127

Query: 125 -------RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
                  R       SYT+ L  +G  RIA+K+GEE  E  +AA   +   +  EA+DL+
Sbjct: 128 LASIIAARAVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADLL 187

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLLQ  G+    V   L+ R 
Sbjct: 188 YHLLVLLQASGVPAGEVWRVLQARR 212


>UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc
           (Cinara cedri) RepID=Q058A1_BUCCC
          Length = 205

 Score =  226 bits (577), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 93/204 (45%), Positives = 131/204 (64%), Gaps = 1/204 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           ML +Q  + L+W K +GL+P I QH +SGE+LM GYMN +A DK + +   T +SR K+R
Sbjct: 1   MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-GDTAHQWLFLYQLE 119
           +W KGETS NFL V +I+ DCD D +LV  NP G TCH    SCF       + FLY+LE
Sbjct: 61  IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
             +  +K     +SY + L++SG  RIAQK+GEE VE  +A   ++   + NE SDL++H
Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           L +LLQ   ++L  +I+NL+KR +
Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204


>UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria
           RepID=HIS2_AQUAE
          Length = 205

 Score =  226 bits (577), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 75/206 (36%), Positives = 116/206 (56%), Gaps = 10/206 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             +L +   +GL+PVI Q   +GEV ML Y N EA+ KTLE+G   ++SR+++++W KGE
Sbjct: 1   MLKLKF-NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGE 59

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDT--------AHQWLFLYQ 117
           TSG    V+ +  DCD D L+ +        CH G  +CF              +  L +
Sbjct: 60  TSGELQKVIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPR 119

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L+ ++ E+     E SYTAKL + G +R+ QK GEE VET +A    ++ E+  E++D++
Sbjct: 120 LQDVIREKIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADML 179

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRHQ 203
           Y  LV L   G+D+  V+E L +R +
Sbjct: 180 YTFLVSLSVSGIDIKEVMEELIRRFK 205


>UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_PYRFU
          Length = 209

 Score =  225 bits (574), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 89/213 (41%), Positives = 124/213 (58%), Gaps = 14/213 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  E+   +++WEK +G++PVIVQ    GEVL L YMN EAL KTLE+G   ++SR+K R
Sbjct: 1   MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL----- 115
           +  KGE SGN   V  I  DCDND LL++ +P GP CH G  SCF     +   +     
Sbjct: 60  IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119

Query: 116 -----YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
                 +LE+++  RK    E SYT+KL+  G ++I +K GEE +E  +A     R  + 
Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E +DL+YHLLVLL    + L  V+  LR+R +
Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209


>UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS
          Length = 257

 Score =  225 bits (574), Expect = 8e-58,   Method: Composition-based stats.
 Identities = 79/244 (32%), Positives = 114/244 (46%), Gaps = 43/244 (17%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M   Q   E+ +    GL+P I QH  +G +LM+ +MN E+L  T E  +  +FSR++Q+
Sbjct: 1   MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFL---- 115
           LW KGE SG+F  V  I  DCD D +++     G   CH G  SCF        +     
Sbjct: 60  LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119

Query: 116 ------------------------------YQLEQLLAERKSADPETSYTAKLYASGTKR 145
                                           L QL+ ERK A+ +TSY + LY  G  +
Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179

Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           I +KVGEEGVET +AA          +  +L  E +DL +H +V+L    L+   +I+ L
Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239

Query: 199 RKRH 202
            +R 
Sbjct: 240 GRRQ 243


>UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_THET2
          Length = 214

 Score =  224 bits (571), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 81/202 (40%), Positives = 118/202 (58%), Gaps = 6/202 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGE
Sbjct: 3   LSAVRFD-EKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQL 121
           TSG+   VV +  DCD D ++    P GP CH G  +CF              + Q+   
Sbjct: 62  TSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYAT 121

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + ER    PE SY A+++ +G  RI +K+GEE  E  LAA   +  EL +EA+DL++HLL
Sbjct: 122 IKERLRTLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLL 181

Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203
           + L + GL    + + L +RH+
Sbjct: 182 LTLAELGLTPEDLAKTLWERHR 203


>UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum
           sp. NBC37-1 RepID=A6Q6T8_SULNB
          Length = 222

 Score =  223 bits (570), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +DW K + L+P I Q A + +VLML YMN EA + TL +G   +FSR+KQR+W KGE+SG
Sbjct: 3   IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115
           +   V  +  DCD DT+++     G  CH G  SCF               DT   +  +
Sbjct: 62  HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121

Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
             L   + ERK+A  E  S+T KL     + +  K+ EE  E  +A       ++  E++
Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV L  + +    V + L +R
Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207


>UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes
           RepID=C6W0Y7_DYAFD
          Length = 213

 Score =  222 bits (566), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 103/211 (48%), Positives = 132/211 (62%), Gaps = 12/211 (5%)

Query: 5   QQRRELDWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    +D+ K  DGL+P ++Q   +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT
Sbjct: 3   ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ------ 117
           KGETSGNFL V  IA DCD DTLL+ A P GP CH G  +CFG+   Q            
Sbjct: 63  KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122

Query: 118 -----LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                 ++++ ERK    + SYT+ L+  G  +IAQKVGEE VE  + +   D     NE
Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            SDL++HLLVLL+ + +DL  VI+ LR RHQ
Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213


>UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4L5_GEMAT
          Length = 207

 Score =  222 bits (565), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 80/204 (39%), Positives = 111/204 (54%), Gaps = 5/204 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M +      LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++  
Sbjct: 1   MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG TSG+   V+S+A DCD D +L      GP CH GT+SCF DTA     +  L+ 
Sbjct: 60  LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119

Query: 121 LLAERKS---ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
            +A R+     D   SYT +L         +K+GEE VE A A    D    T E +DL+
Sbjct: 120 TIAARQQSLRDDERPSYTQRLLT-DRNLRLKKLGEEAVELATACVDGDVERATEETADLL 178

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YH LV L+  G  L  V   L +R
Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202


>UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP
           cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NG19_KYTSD
          Length = 244

 Score =  221 bits (564), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 95/222 (42%), Positives = 123/222 (55%), Gaps = 31/222 (13%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
            +   GL+  +VQ A +  VLM+G+M+  AL+ T  +G+VTF+SR++   W KGETSGN 
Sbjct: 22  TDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVKGETSGNT 81

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG------------------------- 106
           L+VVS+  DCD D +LV+A P GPTCH G +SCF                          
Sbjct: 82  LDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAASGAGGDA 141

Query: 107 ------DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
                  T      +  L + +AER    P  SYT  L+  GT+RIAQKVGEEGVETALA
Sbjct: 142 PASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEEGVETALA 201

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                  EL  E++DL+YHL+VLL D+GL L  V   LR R 
Sbjct: 202 GVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243


>UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
           n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD
          Length = 202

 Score =  219 bits (559), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 70/198 (35%), Positives = 102/198 (51%), Gaps = 5/198 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+   W KG 
Sbjct: 4   LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSGN   VV++  DCD D +L      GP CH GT +CFG      L             
Sbjct: 63  TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAP 122

Query: 127 SADPET---SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +  P+    SYT +L         +K+GEE  E   A    D      EA+D++YH+LV 
Sbjct: 123 AERPDDAPPSYTRRLLE-DRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVA 181

Query: 184 LQDQGLDLTTVIENLRKR 201
           ++  GL L  V   L +R
Sbjct: 182 VRPLGLSLDDVKAVLARR 199


>UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera
           aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR
          Length = 204

 Score =  217 bits (552), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 91/203 (44%), Positives = 125/203 (61%), Gaps = 1/203 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT  Q  +L+W+K + L+P+IVQ   S E+LM GY N ++L  TL+  K+TFFSRTK R
Sbjct: 1   MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LWTKGETS N+L V+ I PDCD D+LL L   IG TCH    SCF    +  +      +
Sbjct: 61  LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120

Query: 121 LLAE-RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            + +  K  +  TSYT+ LY  G  +I+QKVGEE VE  +AA   D+  +  E +DL+YH
Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVL     +    +I+ L+KR+
Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203


>UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=2 Tax=Francisella philomiragia
           RepID=B0TY40_FRAP2
          Length = 207

 Score =  216 bits (550), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 102/204 (50%), Positives = 137/204 (67%), Gaps = 3/204 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +  +    + W+K D L+P I+Q A+   VLMLGYM+ E+L+KTLE GKVTF+SR+K+RL
Sbjct: 1   MDNKIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRL 60

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL--YQLE 119
           WTKGE SGNFL +  IA DCDND++L+ A P GPTCH G+ SCF             +LE
Sbjct: 61  WTKGEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMY 178
           +L+AE+K   PE SY   L+  G  RIAQKVGEEGVE  +AA   D   EL +E +DL++
Sbjct: 121 KLIAEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLF 180

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVLL+++G+ L  + + L  R+
Sbjct: 181 HLLVLLREKGISLEQICQKLVSRN 204


>UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8HTA8_CHLRE
          Length = 308

 Score =  211 bits (538), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 73/226 (32%), Positives = 116/226 (51%), Gaps = 31/226 (13%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L W+K + L+ VIVQH  +GEV+M  + +  A+ +TL++G  TF+SR++   W K
Sbjct: 67  SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107
           GETSG+F+NV ++  DCD D+++ L++PIGP CH G  +C+                   
Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185

Query: 108 -----TAHQWLFLYQLEQLLAERKSA------DPETSYTAKLYASGTKRIAQKVGEEGVE 156
                       L  LE+ +A+R+ A        + S+TA+L     + + +K+ EE  E
Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLL-GNPELLCKKIREEAGE 244

Query: 157 TALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                     R    +E +DL+YH +VL   QG+ +  V+  LRKR
Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290


>UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU
          Length = 284

 Score =  205 bits (523), Expect = 5e-52,   Method: Composition-based stats.
 Identities = 70/220 (31%), Positives = 112/220 (50%), Gaps = 25/220 (11%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+  I Q   +G +LM G+ + +A+  TL + K TF+SR++  LW K
Sbjct: 45  AFLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWCK 103

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL----------- 113
           GETSGNF+ V S+  DCD D+L+ L  P GPTCH G  +C+                   
Sbjct: 104 GETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGRH 163

Query: 114 -------FLYQLEQLLAERK----SADPETSYTAKLYASGTKRIAQKVGEEGVETALA-A 161
                   LY+LE  +  R+    + D + S+T +L  +  + + +K+ EE  E      
Sbjct: 164 AAEEALTTLYELEATIEARRVEAVADDVKPSWTRRLLDN-PELLCKKIREEAGELCQTWE 222

Query: 162 TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +   TNE +D++YH +V+L  QG+ ++ V+  LR+R
Sbjct: 223 ENEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262


>UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta
           RepID=HIS2_ARATH
          Length = 281

 Score =  205 bits (522), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 71/219 (32%), Positives = 111/219 (50%), Gaps = 21/219 (9%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +     + W+   GL   I Q+  +G VLM G++N EAL  T+ S K TFFSR++  L
Sbjct: 51  KVDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTL 109

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL--- 118
           WTKGETS NF+N++ +  DCD D+++ L  P GPTCH G  +C+  +    L   +    
Sbjct: 110 WTKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGN 169

Query: 119 ----------EQLLAERKSADP-----ETSYTAKLYASGTKRIAQKVGEEGVETALAAT- 162
                     E ++++RK         + S+T +L       +  K+ EE  E       
Sbjct: 170 KLALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDDA-LLCSKIREEADELCRTLED 228

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             +     +E +D++YH +VLL  +G+ +  V+E LRKR
Sbjct: 229 NEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267


>UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM
           16069 RepID=C7RAI7_KANKD
          Length = 412

 Score =  199 bits (506), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 68/201 (33%), Positives = 103/201 (51%), Gaps = 6/201 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L E     LD++K   L+P IVQ   +G VLML Y  PE+L   +   K  +FSR++  L
Sbjct: 216 LDEAVMACLDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNEL 274

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG TSGN   +++I  DCD DTL+      G  CH    SCF   +  +     L+++
Sbjct: 275 WEKGLTSGNQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANFDL-DVLDRV 333

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
             +R  +   TS++ KL AS      +K+ EE  E   A    D+ E+  EA+DL++  L
Sbjct: 334 FEQRMQSQEVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFAL 389

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
              + +G+  + +I  L  R+
Sbjct: 390 ARAKSKGVAASDIINELGARN 410


>UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2
           Tax=Campylobacter RepID=B9D5P8_WOLRE
          Length = 329

 Score =  193 bits (490), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P +VQ + SGEVLML YMN EAL+ +L++G   +FSRTK R+W KGE S
Sbjct: 2   KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107
           GN   +  I  DCDNDT+L+     G   CH G  SCF                      
Sbjct: 62  GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121

Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
                      +  + ++   + +RK +ADP+TSY A L+  G   I +KVGEE  E  +
Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181

Query: 160 AATVHD 165
           A     
Sbjct: 182 ACKDAS 187



 Score = 53.7 bits (128), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 13/35 (37%), Positives = 18/35 (51%)

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E+  EA+DL +H LV L   G+    V   L +R
Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  192 bits (487), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 68/203 (33%), Positives = 104/203 (51%), Gaps = 9/203 (4%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT++   E+  ++ DGL   +V        L L Y + +++ K ++ G+  ++SR++  
Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLE 119
           +W KGETSGN   ++ I+ DCD+D L  +        CH  T SCFG+  H    L  LE
Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHG---LVGLE 249

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            LL +R    PE SYT +L+ + +  +  K+ EE  E   A     + EL+ EA+DL Y 
Sbjct: 250 SLLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L  L    + L  V  NL  +H
Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328


>UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira
           pseudonana RepID=B8BUA9_THAPS
          Length = 272

 Score =  187 bits (474), Expect = 3e-46,   Method: Composition-based stats.
 Identities = 58/199 (29%), Positives = 95/199 (47%), Gaps = 13/199 (6%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            +  ++ DGL   +V    SGE L L Y + E++   L+SG+  ++SR++  LW KG+TS
Sbjct: 58  CVKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTS 116

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           G+F  +  +  DCD D L       G      CH  T +C+G+       L  LE  L +
Sbjct: 117 GHFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEP----RGLRHLEGTLQQ 172

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R    P  SYT +L+      +  K+ EE  E + A     +  +  E +D++Y  +V  
Sbjct: 173 RLKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRA 228

Query: 185 QDQGLDLTTVIENLRKRHQ 203
              G+ +   +E L +R +
Sbjct: 229 AKAGVSIDDAVEELDRRTR 247


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  184 bits (468), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 64/209 (30%), Positives = 102/209 (48%), Gaps = 17/209 (8%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +        ++ DGL   +V     G  L L Y + E++ ++L +G+  + SR +  L
Sbjct: 191 VAKLVMANATSDRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-L 248

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE+SG+   +VS++ DCD+D L  +    G   CH  T +CFG     +  L +L++
Sbjct: 249 WYKGESSGDIQELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFG----DYRGLSKLQK 304

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L  RK + P+ SYTA+L+ +  + +  K+ EE  E   A     +  +  EA+DL Y  
Sbjct: 305 TLQSRKESAPQGSYTARLF-NDAQLLRAKILEEATELCDAT---TKEHIAFEAADLFYFA 360

Query: 181 LVLLQDQGLDLTTVIENLR------KRHQ 203
           L      G+ L  V  NL       KR Q
Sbjct: 361 LTKCVAAGVSLEDVERNLDAKSIKVKRRQ 389


>UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira
           RepID=B5VZW9_SPIMA
          Length = 200

 Score =  184 bits (467), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 17/197 (8%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+ + +Q  ++G VL LG MN EAL KTL + ++ +  +++  LW    
Sbjct: 21  IDKIRYD-DQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHP-- 77

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
                + + SI+ D   + L+         C    +   G T         L +++ +R+
Sbjct: 78  ----DIILESISYDYRGNFLVAGV----AYCPSELNGSGGHTL------AGLFRVICDRR 123

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
                 SYT +L+A G  +I +K+GEE  E  +A    +   + +E +DL YH LV L  
Sbjct: 124 DHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAY 183

Query: 187 QGLDLTTVIENLRKRHQ 203
             +DL  V E L  R Q
Sbjct: 184 HQVDLRKVYEQLEARRQ 200


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  183 bits (465), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 62/191 (32%), Positives = 93/191 (48%), Gaps = 10/191 (5%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
             ++ DGL+P +V        L L Y + E++ + L++    + SR +  LW KG TSG+
Sbjct: 202 KSDRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGD 259

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              +V I+ DCDND L  +    G  CH   S CFG        L +LE  L  RK + P
Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFG----DLKGLAKLESTLLSRKQSAP 315

Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190
             SYTA+L+ S  K +  K+ EE  E   A   +    +  EA+DL+Y  L      G+ 
Sbjct: 316 AGSYTARLF-SDEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVT 371

Query: 191 LTTVIENLRKR 201
           L  + ++L  +
Sbjct: 372 LADIEKSLDAK 382


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  178 bits (453), Expect = 7e-44,   Method: Composition-based stats.
 Identities = 59/207 (28%), Positives = 91/207 (43%), Gaps = 11/207 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L  ++TDGL    V  +     L L Y +P ++ K++ +G   + SR +  L
Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CHKGTSSCFGDTAHQWLFLY 116
           W KGE+SG    VVSI  DCD+D +         T     CH                L 
Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENR---EGCFSSATGLA 308

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +LE  L  R    P  SYTA+L+ +    +  K+ EE  E A A   +D+  +  EA+DL
Sbjct: 309 KLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAADL 366

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +Y  L      G+ L  +  +L  + +
Sbjct: 367 IYFALTKCVSAGIGLEEIEASLDAKAK 393


>UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces
           RepID=HIS2_SCHPO
          Length = 417

 Score =  178 bits (453), Expect = 8e-44,   Method: Composition-based stats.
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 11/203 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L +      + ++ DGL   +V + + G  L L Y + E++ ++L++G   + SR +  L
Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KG +SG   +++ I  DCD D L  +    G   CH  T  CFG  +        LE+
Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASGLCQ----LEK 308

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L +RK+  PE SYTA+L+ S  K +  K+ EE  E   A     +  +  E +DLMY  
Sbjct: 309 TLIDRKNNAPEGSYTARLF-SDPKLLRAKIMEEAEELCDAT---TKENVIWEMADLMYFA 364

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +      G+ L  +  +L  +H+
Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387


>UniRef50_A0YJX3 Phosphoribosyl-ATP
           pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase
           n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN
          Length = 198

 Score =  176 bits (446), Expect = 4e-43,   Method: Composition-based stats.
 Identities = 52/197 (26%), Positives = 88/197 (44%), Gaps = 13/197 (6%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ +    GL+P I+Q  + G VL L +M+ ++L KT E  +V     +   L +   
Sbjct: 15  IDKIRY-NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLL 73

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
            +G   +     P C +  +LV    I    ++               L ++ +++ +R+
Sbjct: 74  ITGWRYD-----PACQSLLILVECGSIAEPQNE-------FAQVSSNLLSEVFEVICDRR 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
               E SYT KL A G  +I +K+GEE  E  +A    D   + +E +DL YH LV +  
Sbjct: 122 DHPQEDSYTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAY 181

Query: 187 QGLDLTTVIENLRKRHQ 203
              DL  V   L +R +
Sbjct: 182 HRADLRQVYRKLAERRR 198


>UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms
           RepID=HIS3_PELLD
          Length = 137

 Score =  172 bits (436), Expect = 7e-42,   Method: Composition-based stats.
 Identities = 49/136 (36%), Positives = 74/136 (54%), Gaps = 6/136 (4%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +       + ++   GL+P IVQ   +G+VLM+ +MN E+L+ TLE  K  ++SR++ +L
Sbjct: 7   IDNSFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKL 65

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGE+SGN  +V  I  DCD DTL++  + IG  CH G  SCF     +   +      
Sbjct: 66  WLKGESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYRRVLENGNME----- 120

Query: 122 LAERKSADPETSYTAK 137
           + +    DPE  Y  K
Sbjct: 121 ICDTLMFDPEEVYGKK 136


>UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4CVB3_9BACT
          Length = 128

 Score =  169 bits (428), Expect = 6e-41,   Method: Composition-based stats.
 Identities = 52/131 (39%), Positives = 71/131 (54%), Gaps = 5/131 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L +   DGL+P IVQ   +  VLM+ +MN  +L+ TL++G + ++SR++Q+ W KGE
Sbjct: 3   LPNLKY-TADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSG+   VV  A DCD DTLL     IG  CH G  SCF                + E K
Sbjct: 62  TSGHTQKVVRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSPEGTP----LEITEEK 117

Query: 127 SADPETSYTAK 137
             DPE +Y +K
Sbjct: 118 LFDPEKTYASK 128


>UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN
          Length = 477

 Score =  168 bits (425), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 10/198 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
              + L  ++ D L   +V    +G  L L Y + E++   + SG+  ++SR++  LW K
Sbjct: 244 AFVKCLRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKK 302

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE+SGN   ++ I  DCD+D L    N  G   CH  T +C+G        L  LE +L 
Sbjct: 303 GESSGNAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHD----GGLRALESMLF 358

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R    P  SYT +L+    + +  K+     E    A      ++  EA+D+MY  +V 
Sbjct: 359 SRHENAPAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVR 414

Query: 184 LQDQGLDLTTVIENLRKR 201
               G  L+ V   L KR
Sbjct: 415 CVAAGCKLSDVERMLDKR 432


>UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_CHLP8
          Length = 137

 Score =  167 bits (424), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +     + ++   GL+P IVQ   +G+VLM+ +MN E+L  TLE  K  ++SR++ +LW 
Sbjct: 9   KSFLETVKFD-DRGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE+SGN  +V  I  DCD DTLL+  +  G  CH G  SCF         +      + 
Sbjct: 68  KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQME-----IC 122

Query: 124 ERKSADPETSYTAK 137
           +    DPE  Y  K
Sbjct: 123 DTLMFDPEEVYGKK 136


>UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT
          Length = 116

 Score =  166 bits (422), Expect = 3e-40,   Method: Composition-based stats.
 Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 2/108 (1%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L +   D L+P I Q    G VLM+ +MN E++ KTL +G+  ++SR++ +LW KG
Sbjct: 7   WFEKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKG 65

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112
            TSG+   V  +  DCD DT+L+    IG   CH G  SCF +    +
Sbjct: 66  ATSGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113


>UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria
           RepID=HIS3_RHOPT
          Length = 151

 Score =  166 bits (422), Expect = 3e-40,   Method: Composition-based stats.
 Identities = 43/136 (31%), Positives = 72/136 (52%), Gaps = 2/136 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + E       ++   GL+ V+   A +G+VLM+ +MN EALD+T+++G+  ++SR+++RL
Sbjct: 17  IEEGVVLRPKFD-AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRL 75

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGETSG+   V+ +  DCD D + +  +   G  CH G  SCF     +      +  
Sbjct: 76  WKKGETSGHIQKVLEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLI 135

Query: 121 LLAERKSADPETSYTA 136
                +  DP+  Y  
Sbjct: 136 ETDAERKFDPDKVYGK 151


>UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=C4XTP1_DESMR
          Length = 124

 Score =  165 bits (419), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 58/129 (44%), Positives = 74/129 (57%), Gaps = 7/129 (5%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            +  D+ K  GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG 
Sbjct: 1   MKRPDFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGG 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
           TSG+   V S+  DCD DT+LVL   I G  CH+G  SCF              +     
Sbjct: 61  TSGHVQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFFTEITSDG------ERTCSP 114

Query: 126 KSADPETSY 134
           K  DP+  Y
Sbjct: 115 KVFDPKEVY 123


>UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae
           RepID=HIS3_ACIC1
          Length = 142

 Score =  165 bits (419), Expect = 6e-40,   Method: Composition-based stats.
 Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 4/135 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       L      GL P + Q   +GEVLM+G+M+ EAL +TL +G+ T++SR++Q  
Sbjct: 8   LDPAIAARLK-RDEHGLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEY 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGETSG+   V S+A DCD DT+LV  + IG  CH G  +CF       +       +
Sbjct: 67  WVKGETSGHQQWVKSVALDCDGDTVLVKVDQIGAACHTGDRTCFDAGQLPAVVGEPPTPV 126

Query: 122 LAERKSADPETSYTA 136
            A  +      S TA
Sbjct: 127 GAGERQ---PASGTA 138


>UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_STRTD
          Length = 112

 Score =  165 bits (419), Expect = 7e-40,   Method: Composition-based stats.
 Identities = 47/106 (44%), Positives = 65/106 (61%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD++K  GL+PVIV    +G+VLML YMN  +   TLE+ ++ ++SR++  LW KG TS
Sbjct: 5   KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           G+F +V SI  DCD DTLL+     G  CH G  SCF    +    
Sbjct: 65  GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYDDNQ 110


>UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria
           RepID=B8J3P0_DESDA
          Length = 137

 Score =  165 bits (418), Expect = 8e-40,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 7/129 (5%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
                + + GL+P I Q   SGEVLML YMN EA  KTLE+G+  ++SR+++++W KG T
Sbjct: 14  EAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGT 73

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           SG+   V+++  DCD+DT+L+  + + G  CH G  +CF                     
Sbjct: 74  SGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE------WKDGAVSECAPM 127

Query: 127 SADPETSYT 135
             DP+  Y 
Sbjct: 128 VFDPQKVYG 136


>UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3
          Length = 140

 Score =  165 bits (418), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 70/133 (52%), Gaps = 5/133 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + ++K +GL+P I Q   +G+VLML YMN E+L+ TL+  K  ++SR++Q LW K
Sbjct: 10  KLMDIVRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQELWLK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           G TSGNF  V+ I+ DCD D +L+     G  CH G  SCF                + +
Sbjct: 69  GATSGNFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVEN----DNSSLSICD 124

Query: 125 RKSADPETSYTAK 137
           +   D E  Y   
Sbjct: 125 KLVFDAEEVYGKS 137


>UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae
           RepID=HIS3_FRAAA
          Length = 132

 Score =  164 bits (416), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 49/126 (38%), Positives = 65/126 (51%), Gaps = 1/126 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       L      GL P I Q   +GEVLMLG+M+ EAL +TL +G+ T++SR++   
Sbjct: 8   LDPAIASRLR-RNDAGLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEY 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG+TSG+   V S+A DCD D +LV  + IGP CH GT +CF                
Sbjct: 67  WVKGDTSGHQQWVRSVALDCDGDAVLVRVDQIGPACHTGTRNCFVADPLPTRVGDPGVTA 126

Query: 122 LAERKS 127
            A    
Sbjct: 127 DAGPAR 132


>UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_RHOPS
          Length = 147

 Score =  163 bits (414), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 45/124 (36%), Positives = 69/124 (55%), Gaps = 1/124 (0%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +   A SGEVLM+ +MN EAL+KT++SG+  ++SR+++RLW KGE+SG+
Sbjct: 23  KFDAA-GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRLWKKGESSGH 81

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              V+ I  DCD D + +     G  CH G  SCF     +      L  ++   +  DP
Sbjct: 82  VQRVLEIRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTMVDADRLFDP 141

Query: 131 ETSY 134
              Y
Sbjct: 142 AKIY 145


>UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria
           RepID=Q2SLC2_HAHCH
          Length = 139

 Score =  163 bits (414), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 45/111 (40%), Positives = 66/111 (59%), Gaps = 1/111 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                EL +    GL+PVI Q A +  +LM  +MN EAL+KT+ + ++T++SR++QRLW 
Sbjct: 21  PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           KGETSG+   +VS++ DCD D +L L +  G  CH G  +CF         
Sbjct: 80  KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFYLQVEPDKQ 130


>UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales
           RepID=C4Z0A8_EUBE2
          Length = 362

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 51/113 (45%), Positives = 71/113 (62%), Gaps = 1/113 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +   ++L  +  +GL+PV+VQ  V+ EVLML YMN EA +KTLE+G +T++SR++Q L
Sbjct: 251 KADISFKDLKLD-ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQEL 309

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           W KG TSG+F  V S+  DCDNDT+L     +G  CH G  +CF      W  
Sbjct: 310 WVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWNR 362


>UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R0U5_9PLAN
          Length = 310

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 40/125 (32%), Positives = 64/125 (51%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
                L+P I Q   +GEVLM+ +MN E+  +T+ +G+  ++SR++ +LW KGE SG+  
Sbjct: 176 RGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESGHMQ 235

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            V  +  DCD DT+L+  + +G  CH+G  SCF             E+L+          
Sbjct: 236 TVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYKNPK 295

Query: 133 SYTAK 137
           S+   
Sbjct: 296 SHAKS 300


>UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria
           RepID=HIS3_BURS3
          Length = 138

 Score =  163 bits (413), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 47/132 (35%), Positives = 71/132 (53%), Gaps = 4/132 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                ++ W+  +GL+PVI Q A + +VLM  +MN EAL KT+E+ +  ++SR+++RLW 
Sbjct: 9   PAWLDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWF 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+  +V  +  DCD D +L+    + G  CH G  SCF       +       + 
Sbjct: 68  KGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFEGTVDNGDWVAVE 127

Query: 123 AERKSADPETSY 134
              K  DPE  Y
Sbjct: 128 PVLK--DPEHIY 137


>UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria
           RepID=HIS3_DINSH
          Length = 119

 Score =  162 bits (411), Expect = 5e-39,   Method: Composition-based stats.
 Identities = 45/115 (39%), Positives = 68/115 (59%), Gaps = 1/115 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             L ++   GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q  W KGE+
Sbjct: 6   ASLRYD-DQGLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGES 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           SG+   +V +  DCD D LL+     GP CH    +CF         +  +  ++
Sbjct: 65  SGHVQTLVEMRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119


>UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria
           RepID=HIS3_SALRD
          Length = 127

 Score =  161 bits (409), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 7/133 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +++      D+   DGL+P IVQ A + +VLM+ YM  E L +TL++G++ ++SR++Q  
Sbjct: 1   MSDPLLDAADF-TDDGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQER 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG+TSG+   V     DCD DTLL   +  G  CH G  SCF   A            
Sbjct: 60  WVKGQTSGHTQTVEEARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAADDG------WT 113

Query: 122 LAERKSADPETSY 134
               K  DP+  Y
Sbjct: 114 TDGEKVFDPDAVY 126


>UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria
           RepID=HIS3_CORJK
          Length = 127

 Score =  161 bits (408), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 60/108 (55%), Gaps = 1/108 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       + +   DGL+P IVQ   +G+VLM+ +MN  AL  TL + K T++SR++Q  
Sbjct: 19  LDPAIAERVRF-NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
           W KGETSG+   V  +  DCD DT+L+     G  CH G  +CF    
Sbjct: 78  WIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFDADR 125


>UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria
           RepID=HIS3_THICR
          Length = 147

 Score =  161 bits (407), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 48/131 (36%), Positives = 72/131 (54%), Gaps = 7/131 (5%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E  ++++ ++  +GL+P I Q   S EVLM+ +MN  AL +TLE+G+V ++SR++Q  W 
Sbjct: 22  EAVKKQVKYD-DNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR 80

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE SG    +  +  DCD D +L+L +  GP CH G  SCF    H          ++ 
Sbjct: 81  KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPII- 139

Query: 124 ERKSADPETSY 134
                DPE  Y
Sbjct: 140 -----DPEALY 145


>UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria
           RepID=HIS3_SILST
          Length = 129

 Score =  160 bits (405), Expect = 3e-38,   Method: Composition-based stats.
 Identities = 43/107 (40%), Positives = 61/107 (57%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P I Q   SGE+LM+ +MN E++ KTLE+G+VT++SR++Q  W KGE+SG+   
Sbjct: 21  NEAGLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQE 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           +V +  DCD D LL +    GP CH    SCF            +  
Sbjct: 81  LVELRVDCDRDALLAMVRQTGPACHTNRRSCFYTAIRDGEEHEIMTP 127


>UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_RALEJ
          Length = 135

 Score =  160 bits (404), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 49/137 (35%), Positives = 73/137 (53%), Gaps = 4/137 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   ++ W+  +GL+PVIVQ   + +VLM  +MN +AL KT E G+  F+SR+++RL
Sbjct: 1   MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE SG+   V  +  DCD D +L+    +    CH G  SCF             + 
Sbjct: 60  WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEGDAESGDWQT 119

Query: 121 LLAERKSADPETSYTAK 137
           +    K  DP   YTAK
Sbjct: 120 VEPVLK--DPSQIYTAK 134


>UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota
           RepID=HIS3_HALWD
          Length = 132

 Score =  160 bits (404), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 53/131 (40%), Positives = 73/131 (55%), Gaps = 10/131 (7%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ +  +DGL+P I Q A SGEVLML Y++P AL +T E+G+  ++SR+++ LW 
Sbjct: 11  DDAEIEIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWK 69

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGETSG+  ++  I  DCD DT+L L    G  CH G  SCF  T               
Sbjct: 70  KGETSGHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRTLDGTEVT-------- 121

Query: 124 ERKSADPETSY 134
             +  DPET Y
Sbjct: 122 -ERVFDPETVY 131


>UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM
          Length = 151

 Score =  159 bits (403), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 45/113 (39%), Positives = 62/113 (54%), Gaps = 1/113 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               +L +    GL+P + Q A +G+VLML +MN  A++KTLE+G++T+FSR++  LW K
Sbjct: 33  DVIEQLAY-NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVK 91

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
           G  SGN   +V    DCD D LL      G  CH G  SCF   A+       
Sbjct: 92  GLASGNHQQLVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVY 144


>UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_METTH
          Length = 138

 Score =  159 bits (403), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             + L+  + Q   +GEVLM+ YMN EAL +TLE+G   ++S ++ +LW KGE+SG+   
Sbjct: 19  NGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQR 78

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
           V  +  DCD D +++     G  CH G  SCF  +        + + +    K  DPE  
Sbjct: 79  VKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----KVFDPEEI 134

Query: 134 YT 135
           Y 
Sbjct: 135 YG 136


>UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca
           ATCC 27029 RepID=D1SGQ9_9ACTO
          Length = 444

 Score =  159 bits (403), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 45/117 (38%), Positives = 62/117 (52%), Gaps = 1/117 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L      +L     DGL+  +V+   SGEVLM+ +M+ EAL +TL +G+ T++SR++   
Sbjct: 329 LDPAVAAKLR-RTPDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEY 387

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           W KG TSGN   V S+A DCD D LLV    +G  CH G  +CF             
Sbjct: 388 WVKGATSGNHQYVRSVALDCDGDALLVSVEQVGAACHTGQRTCFFTELPVSTPEATP 444


>UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured
           crenarchaeote RepID=Q702A1_9CREN
          Length = 115

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 42/111 (37%), Positives = 67/111 (60%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   +LD+ K DGL+PV+VQ   + ++LML Y N  A++ T+++G   F+S ++ +L
Sbjct: 5   IQDEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKL 64

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112
           W KGE SGN   V  I  DCD D++L L +   P CH G  +CF +  +  
Sbjct: 65  WMKGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHNRLYPN 115


>UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_GEOSF
          Length = 126

 Score =  159 bits (402), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++D++K  GL+P ++Q   SGEVLM+ +M+ + LD TL+ GK  FFSRT+ + W KGE
Sbjct: 1   MIKIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
            SGN   V+ +  DCD DT+++     GP  CH G  SCF       +     + +    
Sbjct: 61  ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFY------VKWEDGQWVEHSN 114

Query: 126 KSADPETSY 134
              DP   Y
Sbjct: 115 PLFDPNEVY 123


>UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC
           49814 RepID=C6XNB8_HIRBI
          Length = 139

 Score =  158 bits (401), Expect = 8e-38,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 59/108 (54%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+  I Q   S EVLML +MN +AL  T+E+G+  ++SR++ +LW KG+TSG +  
Sbjct: 30  NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           V SI  DCD D +L+        CH G  SCF         L   E  
Sbjct: 90  VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYRQITDLSTLNPTEDK 137


>UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria
           RepID=B9QYY7_9RHOB
          Length = 159

 Score =  158 bits (401), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            +++ DGL+  +V    + EVLM+GYMN EAL +T+E+G+  ++SR+++  W KGETSG 
Sbjct: 32  KFDQ-DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQ 90

Query: 71  FLNVVSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D L+V       G TCH G  SCF                + + K  
Sbjct: 91  IQKVQEILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANVEKEKVY 150

Query: 129 DPETSYTA 136
           DP+  Y  
Sbjct: 151 DPKKVYGK 158


>UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268
           RepID=C8PI34_9PROT
          Length = 336

 Score =  158 bits (401), Expect = 9e-38,   Method: Composition-based stats.
 Identities = 54/142 (38%), Positives = 67/142 (47%), Gaps = 3/142 (2%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P IVQ A  G VLML YMN EAL  TL +G   +FSR+K R+W KGE S
Sbjct: 2   KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWL-FLYQLEQLLAERK 126
           G+   V S   DCDND LL+     G   CH G  SCF                      
Sbjct: 62  GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKEISLQKCGENVGSSSTCGAI 121

Query: 127 SADPETSYTAKLYASGTKRIAQ 148
           +     S T  L    ++    
Sbjct: 122 NFAEHGS-TTSLAQKNSENSRA 142



 Score = 62.6 bits (151), Expect = 8e-09,   Method: Composition-based stats.
 Identities = 28/132 (21%), Positives = 46/132 (34%), Gaps = 24/132 (18%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVG 151
                +             +  L ++  +  +RK    P  SY A LYA G     +K+ 
Sbjct: 194 DAAAQNSTLE--NSAEKGPYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251

Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190
           EE  E ALA     R EL  + +              D++Y        LL+ L    + 
Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311

Query: 191 LTTVIENLRKRH 202
              +++ L +R 
Sbjct: 312 PDALLDELARRQ 323


>UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria
           RepID=A4GIE4_9BACT
          Length = 132

 Score =  158 bits (400), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 42/118 (35%), Positives = 68/118 (57%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q   +GEVLM+ +MN  +L +TL +G++ ++SR+++ LW KG+TSG+   +
Sbjct: 15  ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
           + +  DCD D++LVL +  G  CH+GT SCF         + + E     +       
Sbjct: 75  IELRYDCDADSILVLVDQSGAACHEGTRSCFTRRLEIDGSISEAETAYPTKIDESARQ 132


>UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium
           HTCC2255 RepID=Q0FGM5_9RHOB
          Length = 120

 Score =  158 bits (400), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 43/121 (35%), Positives = 65/121 (53%), Gaps = 1/121 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L ++  +GL+P +VQ   + EVLM+ +MN  +L+KT E+   TF+SR+++ L
Sbjct: 1   MAKFDISSLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG TSGN   V  +  DCD D +L+L  P GP CH    +CF     +      L   
Sbjct: 60  WVKGLTSGNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTELEEGSENIILNPE 119

Query: 122 L 122
            
Sbjct: 120 T 120


>UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R0N1_9RHOB
          Length = 156

 Score =  158 bits (400), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 47/138 (34%), Positives = 69/138 (50%), Gaps = 5/138 (3%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L ++   + D    +GL+   V    SGE+LM+GYMN E+L +T+E+G+  ++SR++Q  
Sbjct: 21  LGDELCPKFD---ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           W KG TSG    V+ I  DCD D +   V  +  G TCH G  SCF    +         
Sbjct: 78  WKKGGTSGQVQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWL 137

Query: 120 QLLAERKSADPETSYTAK 137
           +        DP+  Y  K
Sbjct: 138 EKTEVAPVYDPQEVYGKK 155


>UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms
           RepID=HIS3_SOLUE
          Length = 126

 Score =  157 bits (397), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 56/130 (43%), Positives = 78/130 (60%), Gaps = 7/130 (5%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            LD+ K+DGL+  ++Q   SG VLM+GYMN EA +KT+E+G  TF+SR++++LW KGE+S
Sbjct: 2   NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           G+ L V  I+ DCD D +LV     GP  CH+G  SCF             E  +A+  +
Sbjct: 62  GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRRL------DAGEWKVADNPT 115

Query: 128 ADPETSYTAK 137
            DP   Y  K
Sbjct: 116 YDPGAVYGGK 125


>UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae
           RepID=HIS3_GLUOX
          Length = 156

 Score =  157 bits (397), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 2/124 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +    ++ ++  +GL+  + Q A  G VLML +MN +AL +TL +G+V ++SR++Q+L
Sbjct: 30  IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGETSG    ++    DCD D +L++ +  G  CH G  SCF             +  
Sbjct: 88  WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYHGVTPDGLRDTSQPE 147

Query: 122 LAER 125
           ++  
Sbjct: 148 ISAE 151


>UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria
           RepID=HIS3_CHRSD
          Length = 146

 Score =  157 bits (397), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 49/135 (36%), Positives = 68/135 (50%), Gaps = 7/135 (5%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T        W    GL+P I Q   SGEVLM+ +MN  AL++TL +G+V ++SR++ + W
Sbjct: 19  TRDLLDAARW-NDAGLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
            KGE+SG    +V+   DCD DTLL+  +  GP CH G  SCF               L+
Sbjct: 78  RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFYVALGADTAHVDSAPLV 137

Query: 123 AERKSADPETSYTAK 137
                 DP   Y  +
Sbjct: 138 ------DPHELYGER 146


>UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria
           RepID=HIS3_BIFLI
          Length = 136

 Score =  156 bits (396), Expect = 3e-37,   Method: Composition-based stats.
 Identities = 46/104 (44%), Positives = 64/104 (61%), Gaps = 1/104 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L  +    L      GL+  ++Q   + EVLM+GYMN EAL +TL +G+VTF+SR++Q  
Sbjct: 12  LDPRIAARLK-RDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEY 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           W KG+TSG+   V  ++ DCD D LLV  + +G  CH G  SCF
Sbjct: 71  WRKGDTSGHVQYVKGVSLDCDGDALLVEVDQVGAACHTGKRSCF 114


>UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class)
           RepID=HIS3_CLAMS
          Length = 138

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 46/107 (42%), Positives = 65/107 (60%), Gaps = 1/107 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            +       +   DGL+P ++Q   + EVLMLGYM+ EAL +TL +G+VTF+SR++   W
Sbjct: 16  VDGILARASF-ADDGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYW 74

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
            KG+TSG+   V   A DCD DT+LV  + +G  CH GT +CF    
Sbjct: 75  RKGDTSGHGQYVRDAALDCDGDTVLVQVDQVGVACHTGTRTCFDADH 121


>UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii
           'Deep ecotype' RepID=B4RV64_ALTMD
          Length = 133

 Score =  156 bits (394), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 46/110 (41%), Positives = 68/110 (61%), Gaps = 1/110 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   EL+++  DGL+PVI Q   S +VLM  +M+ E+LD+TL +GK+ ++SR++Q LW 
Sbjct: 20  DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           KG +SG+   V SIA DCD D LL   + +G  CH    SCF     +  
Sbjct: 79  KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFYLRFWEDK 128


>UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F746
          Length = 123

 Score =  156 bits (394), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 48/111 (43%), Positives = 67/111 (60%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T +  REL    +DGL+PVIVQ   + EVLM+ +M+ EA+++TL +G   ++SR++Q  W
Sbjct: 13  TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
            KGETSGN   V S++ DCD D LL+     GP CH  T +CF        
Sbjct: 73  VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCFTGRTISAN 123


>UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria
           RepID=HIS3_ACIAC
          Length = 141

 Score =  155 bits (392), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 52/134 (38%), Positives = 68/134 (50%), Gaps = 11/134 (8%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               E+ W+   GL+PVI Q A +G+VLM  +MN EAL KT E G+  +FSR++ RLW K
Sbjct: 14  SWLDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFK 72

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           GE SG+   V  I  DCDND +L+    +    G  CH G  SCF               
Sbjct: 73  GEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFSVLKD------GAW 126

Query: 121 LLAERKSADPETSY 134
              +    DPE+ Y
Sbjct: 127 QAVDPVLKDPESIY 140


>UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides
           RepID=Q03VY1_LEUMM
          Length = 132

 Score =  155 bits (392), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 49/129 (37%), Positives = 71/129 (55%), Gaps = 2/129 (1%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M+  +   + + +  +GL+P ++  A +   LMLGYMN E+   T  +G+  F+SR +Q 
Sbjct: 1   MIGTE--PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQE 58

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGETSGN   VVS+  DCD DTLL+  NP GP CH    SCF +T          + 
Sbjct: 59  LWHKGETSGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQA 118

Query: 121 LLAERKSAD 129
            +A + +  
Sbjct: 119 TIANKWTDG 127


>UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_PSEU2
          Length = 130

 Score =  154 bits (390), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 8/132 (6%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ W  +DGL+P I Q   +G VLM+ +MN EAL  T    +  ++SR++ +LW 
Sbjct: 2   KDWLDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+   +  +  DCD D ++++   IG   CH G  SCF           +     
Sbjct: 61  KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFY------RVYEKSGWKT 114

Query: 123 AERKSADPETSY 134
            +    DP+  Y
Sbjct: 115 VDPVLKDPDAIY 126


>UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales
           RepID=HIS3_RHISN
          Length = 152

 Score =  153 bits (387), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 64/129 (49%), Gaps = 4/129 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  A  GE+LM+ +MN EAL  T+E+G   ++SR++  LW KGE+SGN
Sbjct: 24  RFD-EKGLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGN 82

Query: 71  FLNVVSIAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D + +     G   TCH G  SCF  T        ++      R   
Sbjct: 83  TQAVQEIRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARVTITDEHR-HF 141

Query: 129 DPETSYTAK 137
           DP   Y  K
Sbjct: 142 DPAQIYAEK 150


>UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium
           amycolatum SK46 RepID=UPI000185C2AA
          Length = 132

 Score =  153 bits (387), Expect = 3e-36,   Method: Composition-based stats.
 Identities = 41/103 (39%), Positives = 59/103 (57%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                 +     DGL+P IVQ   +G VLM+ +M+  AL  T+ + + T++SR++   W 
Sbjct: 23  PADIANIAKFNADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWI 82

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           KG TSG+F  V S+A DCD DT+L+     G  CH G+ SCF 
Sbjct: 83  KGLTSGHFQTVTSLALDCDGDTVLMQVVQDGAACHTGSHSCFD 125


>UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae
           RepID=HIS3_METS3
          Length = 132

 Score =  153 bits (387), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 5/131 (3%)

Query: 9   ELDWE---KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           E+++        ++  I Q   +G++LM+  MN +AL KT+E+GK  ++S ++   W KG
Sbjct: 2   EINFRHEINGQKVITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE- 124
           E+SG+   V  I  DCD D +++     G  CH+G  SCF    +        E+ L   
Sbjct: 62  ESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLETI 121

Query: 125 -RKSADPETSY 134
             K  +P+  Y
Sbjct: 122 LEKVFNPDDVY 132


>UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria
           RepID=HIS3_BACCN
          Length = 101

 Score =  152 bits (385), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 43/94 (45%), Positives = 61/94 (64%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P IV +  + EVLML YMN EA +KTL++ K  F+SR++Q LW KG TSG+  +V
Sbjct: 6   SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            S+  DCD D +++  N +G  CH G  +CF   
Sbjct: 66  KSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99


>UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms
           RepID=C7NRL7_HALUD
          Length = 138

 Score =  151 bits (383), Expect = 9e-36,   Method: Composition-based stats.
 Identities = 49/126 (38%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +L +E  + L P + Q A SG+VLML Y+  EALD+T E+G   ++SR++  LW KGETS
Sbjct: 22  DLAFEDNEYL-PAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETS 80

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           GN  ++  I  DCD D LL +    G  CH G  SCF  T         ++  +   +  
Sbjct: 81  GNVQHLKEIRVDCDGDALLYVIEQDGGACHTGFQSCFHRT---------IDGEVVGERVF 131

Query: 129 DPETSY 134
           DP+  Y
Sbjct: 132 DPDDVY 137


>UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria
           RepID=C7RQA3_9PROT
          Length = 142

 Score =  151 bits (382), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 40/107 (37%), Positives = 64/107 (59%), Gaps = 1/107 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +   EL +++  GL+  I Q   + E+LML +MN  A+++TL +G   ++SR+++ +W K
Sbjct: 18  EVLDELAFDQ-QGLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111
           GETSG    V+    DCD D +L+L + +G  CH G SSCF +    
Sbjct: 77  GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRN 123


>UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA
          Length = 126

 Score =  151 bits (382), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 42/108 (38%), Positives = 60/108 (55%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
             L+P I Q A +G VLML +MN EA D+T+   +  +FSR++ +LW KG+TSG+   V 
Sbjct: 19  QPLLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVVR 78

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
            I  DCD DT+L+     G  CH+   SCF          +  E+ +A
Sbjct: 79  EIRVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERIA 126


>UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13
           RepID=B6BVA2_9PROT
          Length = 129

 Score =  151 bits (381), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 51/131 (38%), Positives = 76/131 (58%), Gaps = 6/131 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               ++ W    GL+P I+Q   S +V+M+ +MN EAL KT+E+ +  F+SR++ ++W K
Sbjct: 2   NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE SGNF NVVSI  DCD D+LLV  N   G +CH G +SCF +          + + + 
Sbjct: 61  GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120

Query: 124 ERKSADPETSY 134
           +    DP+  Y
Sbjct: 121 K----DPKLIY 127


>UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales
           RepID=HIS3_MYCBP
          Length = 115

 Score =  151 bits (381), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 41/106 (38%), Positives = 63/106 (59%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +         DGL+  +VQ   SG+VLM+ +MN EAL +TL++ + T++SR++  
Sbjct: 1   MTLDPKIAARLKRNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAE 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
            W KG TSG+  +V S+  DCD D +L+  + +G  CH G  SCF 
Sbjct: 61  QWVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFD 106


>UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G191_ABIDE
          Length = 295

 Score =  150 bits (378), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 49/113 (43%), Positives = 66/113 (58%), Gaps = 1/113 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+P IVQ   +G VL + YMN E+L+ TL      F+SR+++ LW KGE
Sbjct: 18  IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           TSGN+ +VVSI  DCD D LLV     G  CH+G  SCF DT         +E
Sbjct: 77  TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDTMKIEFEENIME 129


>UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RPU9_FIBSS
          Length = 116

 Score =  150 bits (378), Expect = 3e-35,   Method: Composition-based stats.
 Identities = 51/116 (43%), Positives = 68/116 (58%), Gaps = 5/116 (4%)

Query: 1   MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57
           M  E   +E+ +E   G   L P IVQ A  G+VLM+ +MN EAL +T E G++ F+SR+
Sbjct: 1   MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60

Query: 58  KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTAHQ 111
           ++  W KG+TSGN + VV  A DCD+D LL      GP   CH G  SCF  T  +
Sbjct: 61  RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTCDK 116


>UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI
          Length = 161

 Score =  150 bits (378), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 48/140 (34%), Positives = 69/140 (49%), Gaps = 8/140 (5%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E       ++  +GL+PV+   A +GEVLM  YMN EAL KT+E+G+  ++SR++Q+LW 
Sbjct: 16  EGLLLAPKFD-CNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWH 74

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQ-----WLFLY 116
           KG++SG    V  +A D D D L +       G +CH G  SCF                
Sbjct: 75  KGQSSGLVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEP 134

Query: 117 QLEQLLAERKSADPETSYTA 136
                    K+ DP+T Y  
Sbjct: 135 IQLTFTETEKTFDPKTVYGN 154


>UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41B27
          Length = 137

 Score =  149 bits (377), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 40/136 (29%), Positives = 69/136 (50%), Gaps = 9/136 (6%)

Query: 9   ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           EL++    G   L+  + Q   + +VLM+ +MN EA+++TL++ K  ++S ++Q+ W KG
Sbjct: 2   ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFL------YQLE 119
           E+SGN   V  +  DCD D +++  + IG  CH+G  SCF                   +
Sbjct: 62  ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDED 121

Query: 120 QLLAERKSADPETSYT 135
             +   +  DP+  Y 
Sbjct: 122 ISIISERLFDPKEMYG 137


>UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter
           necessarius RepID=B1XSV4_POLNS
          Length = 140

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 2/103 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W    GL+PVI Q   S ++LM+ +MN +AL +TL  G+  +++R++Q+LW K
Sbjct: 21  SWLDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHK 79

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106
           GE SG+   V  I  DCD DT+L+L     G  CH G  SCF 
Sbjct: 80  GEESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122


>UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_MESSB
          Length = 139

 Score =  149 bits (376), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 45/113 (39%), Positives = 63/113 (55%), Gaps = 3/113 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+  +V  A  G +LM+ +MN EAL KTLE+G   ++SR++  LW KGETSGN
Sbjct: 27  RFD-ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGN 85

Query: 71  FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
             +V SI+ DCD D +L+       G TCH G  SCF            L + 
Sbjct: 86  LQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRNVKVEDGRPILTEN 138


>UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae
           RepID=HIS3_PYRCJ
          Length = 128

 Score =  148 bits (374), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 38/103 (36%), Positives = 60/103 (58%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
             + L++    G +  +VQ   +GEVLM+G+M+P A+  TL +G   ++S +++R+W KG
Sbjct: 15  IAKSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLKG 74

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           ETSG++  V     DCD D +++    IG  CH G  SCF   
Sbjct: 75  ETSGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSP 117


>UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1
           RepID=A3WCC9_9SPHN
          Length = 143

 Score =  148 bits (373), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 47/98 (47%), Positives = 65/98 (66%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  + + EVL++ +MN +AL KT E+GKV F+SR++  LW KGETSGN
Sbjct: 32  KFD-ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGN 90

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L+V  I  DCD D L++ A P GPTCH G +SCF   
Sbjct: 91  VLSVDEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128


>UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P0M4_9BACE
          Length = 108

 Score =  146 bits (369), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 50/97 (51%), Positives = 71/97 (73%), Gaps = 1/97 (1%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           ++K++ L+PVI+Q A + EVLMLG+ N EA++ TL++    F+SR++Q+LW KGETSG+F
Sbjct: 8   FQKSE-LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHF 66

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           L+V  +  DCD DTLL   +P+GPTCH G  SCF   
Sbjct: 67  LHVERMVTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103


>UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ
          Length = 149

 Score =  146 bits (369), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 50/133 (37%), Positives = 68/133 (51%), Gaps = 19/133 (14%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+P IV  A SG VLM  +MN +AL +T+ +G   F+SR++ +LW KGE SGN L+V
Sbjct: 29  SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88

Query: 75  VSIAPDCDNDT--LLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
             +  DCD D   LL      G  CH G  SCF                   R  A P++
Sbjct: 89  KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR-----------------RLIASPDS 131

Query: 133 SYTAKLYASGTKR 145
           S +  L ++G   
Sbjct: 132 SGSLSLESAGLPL 144


>UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales
           RepID=HIS3_ERYLH
          Length = 125

 Score =  145 bits (367), Expect = 6e-34,   Method: Composition-based stats.
 Identities = 45/98 (45%), Positives = 62/98 (63%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  DGL+  +VQH  + EVLM+ +MN +ALD T ++G   FFSR++Q LW KG TSGN
Sbjct: 18  KFDS-DGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGN 76

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L V  +  DCD D +++L  P GP CH G  +CF   
Sbjct: 77  TLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE 114


>UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/
           phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus
           Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT
          Length = 127

 Score =  145 bits (365), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 44/130 (33%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           Q   +L +    GL+P ++  A  G+ L L YMN +A+ KT+E+GK+  F R++ RL  K
Sbjct: 2   QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GETSG+  +V  I  DC+ ++L+ +       CH G  SC+                + E
Sbjct: 61  GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQT----NSIQVVE 116

Query: 125 RKSADPETSY 134
            K  DPE  Y
Sbjct: 117 EKVFDPENVY 126


>UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae
           RepID=HIS3_ZYMMO
          Length = 124

 Score =  144 bits (363), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 36/111 (32%), Positives = 64/111 (57%), Gaps = 1/111 (0%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           W+   GL+  ++  A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ 
Sbjct: 15  WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           + +  I  DCD DTL +   P+GP CH G  SCF         +   +  +
Sbjct: 74  MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVEDGHLVTIPKDKI 124


>UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris
           BL2 RepID=B8EQR3_METSB
          Length = 141

 Score =  142 bits (358), Expect = 7e-33,   Method: Composition-based stats.
 Identities = 42/107 (39%), Positives = 57/107 (53%), Gaps = 2/107 (1%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+  + + A  GE+LM+ YMN EAL  TL +G+  ++SR++Q +W KG TSG    V
Sbjct: 30  PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89

Query: 75  VSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
             I  DCD D LL  + A   G  CH G  SCF     +      + 
Sbjct: 90  REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYRRLSETGDGETVL 136


>UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum
           ATCC BAA-798 RepID=D1CF76_THET1
          Length = 300

 Score =  140 bits (354), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 58/210 (27%), Positives = 96/210 (45%), Gaps = 29/210 (13%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W K
Sbjct: 9   NLVDMLQYD-EHGLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLK 67

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GETSG  L+V  + P+C+ ++LL+L +   P  CH G  SCF         +     L  
Sbjct: 68  GETSGRTLHVRELRPNCELNSLLILVDQRLPGACHTGHFSCFYRRLEDGELVEIEPPLFD 127

Query: 124 ER-----------------KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
                              +    ++S T+K+          ++ EE  E  L       
Sbjct: 128 PEDVYSDLSVLLGAYDWLSRQPTIDSSSTSKILHGAGPDPWARLLEEWQEL-LGVLEGTH 186

Query: 167 ------FELTNEASDLMYH---LLVLLQDQ 187
                  +   EA  ++Y      VLL D+
Sbjct: 187 VHKGYYEDAKLEAYQVLYWTCLCYVLLDDR 216


>UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001744401
          Length = 141

 Score =  140 bits (352), Expect = 4e-32,   Method: Composition-based stats.
 Identities = 36/115 (31%), Positives = 56/115 (48%), Gaps = 2/115 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  DGL+P I     + E LM+ YMN E L  T+  G+  ++SR+++ +W KG+TSG 
Sbjct: 28  KFD-ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEIWHKGKTSGE 86

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           F  V  I  DCD D +++    +G   CH    +CF               L+  
Sbjct: 87  FQVVKEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRKVDLENVTAGPVPLVRA 141


>UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales
           RepID=HIS3_METVS
          Length = 136

 Score =  134 bits (338), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 3/102 (2%)

Query: 9   ELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
           +L + K D   L+  I        VLM  +M+ E+L  TL++G + +FS ++ ++W KGE
Sbjct: 20  DLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWMKGE 78

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            S N   V+ +  DCD D LL +    G  CH+G  SCF + 
Sbjct: 79  ESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNK 120


>UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HIS3_IGNH4
          Length = 129

 Score =  133 bits (336), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 1/111 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             ++    L++   D  +  + Q   SG+VLM+  MN EA+ KTL +G V ++S++++ L
Sbjct: 8   EAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKEL 67

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQ 111
           W KG TSG+   +     DCD D++L++        CH+G  SCF     +
Sbjct: 68  WVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEE 118


>UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC
           23134 RepID=A1ZDC3_9SPHI
          Length = 130

 Score =  131 bits (330), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 43/90 (47%), Positives = 59/90 (65%), Gaps = 1/90 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            +EK  GL+PV+VQ   SG+VLMLGY N  AL +TL++G  TF+S ++  LWTKG+TSG+
Sbjct: 14  QFEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGD 73

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGP-TCHK 99
           +L +  I  DCD D L+     +G   CH 
Sbjct: 74  YLKITHILTDCDQDALVYQVTMMGAGACHT 103


>UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58
           RepID=Q1NG03_9SPHN
          Length = 157

 Score =  129 bits (325), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 45/128 (35%), Positives = 65/128 (50%), Gaps = 5/128 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GLMP IV +A    VLMLGYMN EAL +TL + +  F+SR+++ LW KGE SG 
Sbjct: 22  RFD-AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGF 80

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDT---AHQWLFLYQLEQLLAERK 126
              V  +  D D D L+++     P +CH G  SCF                 + +    
Sbjct: 81  RQRVDHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDKSPVRLRRIEREA 140

Query: 127 SADPETSY 134
           + D +T Y
Sbjct: 141 AFDAKTVY 148


>UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI0001910D6A
          Length = 157

 Score =  126 bits (318), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 74/81 (91%), Positives = 77/81 (95%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR
Sbjct: 77  MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136

Query: 61  LWTKGETSGNFLNVVSIAPDC 81
           LWTKGETSG+ LNVVSIAPDC
Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157


>UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae
           RepID=HIS3_SULSO
          Length = 85

 Score =  124 bits (312), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 35/79 (44%), Positives = 49/79 (62%)

Query: 33  MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92
           M+G MN EAL KTL +G + F+S ++++LW KGETSGNF  +     DCD D +L     
Sbjct: 1   MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60

Query: 93  IGPTCHKGTSSCFGDTAHQ 111
           +GP CH G  +CF  +  +
Sbjct: 61  LGPICHTGNYTCFYRSYDE 79


>UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira
           RepID=HIS3_LEPIN
          Length = 187

 Score =  123 bits (310), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 34/118 (28%), Positives = 57/118 (48%), Gaps = 5/118 (4%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
             L+PV+      G++LM  + N E+   +L++G   +FSR++ +LW KG+TSG+   ++
Sbjct: 75  KNLVPVVAIDLQ-GQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLWKKGDTSGHTQKIL 133

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
            I    D   L+         CH+G  SCF     +        +LL   ++  PE S
Sbjct: 134 QILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERME----GVTWKLLPVPRNFLPEKS 187


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  117 bits (293), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 39/137 (28%), Positives = 66/137 (48%), Gaps = 14/137 (10%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            ++ ++ DCDND +  +    G  CH     CFG+       + +LE+ L  RK + PE 
Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNL----TGIARLEKTLKARKESAPEG 221

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA+L+ +  K +  K+ EE  E   A     + ++  EA+DL+Y  L      G+ + 
Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDA---KTKEDVAFEAADLIYFALTKAVSAGVSVA 277

Query: 193 TVIENLR------KRHQ 203
            + ++L       KR +
Sbjct: 278 DIEKSLDAKGWKVKRRK 294


>UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa
           serovar Patoc RepID=B0SHA6_LEPBA
          Length = 202

 Score =  117 bits (293), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           +    L P + Q  ++G+ LML +   E+L   +ESG  T+FSR++   W KGE SG+F 
Sbjct: 89  DSMPPLSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQ 147

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
            +  I    +   +  + + IG  CH G  SCF     Q   +  +   
Sbjct: 148 KLKQIYVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYSN 196


>UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD
          Length = 101

 Score =  116 bits (290), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+PV+V    SG++LML Y +   L+ T  +G   ++SR++Q +W KG +SG    V ++
Sbjct: 7   LLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQLVQAV 66

Query: 78  APDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAH 110
             DCD D L   VL    G  CH    SCF     
Sbjct: 67  YRDCDGDALNFRVLVLGDGRVCHTRQVSCFHTRLW 101


>UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7
           genomosp. GTL1 RepID=A5KSK8_9BACT
          Length = 125

 Score =  116 bits (290), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 47/103 (45%), Positives = 59/103 (57%), Gaps = 7/103 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +D +  + L+   V       V       M GYMN  A++ TL  G VTFFSRT  +LW 
Sbjct: 20  VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79

Query: 64  KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           KGETSGN L +   I  DCD D+LL+ A P+G TCH G+ SCF
Sbjct: 80  KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCF 122


>UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms
           RepID=HIS2_PELTS
          Length = 98

 Score =  112 bits (280), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 34/95 (35%), Positives = 50/95 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
             +   +  L +++ +R+   P+ SYTA L+  G  +I +K+GEE  E  +AA       
Sbjct: 1   MGEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAA 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E +DL+YHLLVLL   GL    V+  L  R Q
Sbjct: 61  LVGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95


>UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria
           RepID=HIS2_CLOB1
          Length = 110

 Score =  111 bits (279), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 32/95 (33%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            ++   +  L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   D  E
Sbjct: 1   MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  DL YH++VL+ ++ + L  + + L KR +
Sbjct: 61  LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95


>UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria
           RepID=HIS2_LEPBJ
          Length = 92

 Score =  111 bits (277), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 48/91 (52%), Positives = 61/91 (67%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             FL QLE +L +RK   P+ SYTA L+  G  RI +KVGEE  E  +AA   D+ ELT+
Sbjct: 1   MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+DL++HL VLL +Q L L  V+E LRKRH
Sbjct: 61  EAADLLFHLQVLLVEQELSLQDVVEELRKRH 91


>UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=A6LT24_CLOB8
          Length = 108

 Score =  109 bits (274), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 31/84 (36%), Positives = 46/84 (54%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + + +RK+   E SYT  L+  GT +I +KVGEE  E  ++   +++ E  NE  DL Y
Sbjct: 9   YETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINEICDLTY 68

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVL+    + +  V   L KR 
Sbjct: 69  HLLVLMAQMNISIEEVGAELEKRR 92


>UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes
           RepID=HIS2_BACC2
          Length = 107

 Score =  109 bits (273), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 27/84 (32%), Positives = 48/84 (57%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + + ERK +    SYT  L++ G  +I +K+GEE  E  +A   +D+ E+  E  D+ Y
Sbjct: 9   YKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVFY 68

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           H  VLL ++ + L  V+  +++R+
Sbjct: 69  HCFVLLAEKNIALEDVMREVKERN 92


>UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5
          Length = 105

 Score =  108 bits (271), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 51/90 (56%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L  ++ +RK    + SYT  L+  G  +I +KVGEE  E  +A+   ++ +   E 
Sbjct: 1   MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            DL+YH+LVL+ ++ + L  + + L KR Q
Sbjct: 61  CDLIYHVLVLMANENITLEELRKELEKRRQ 90


>UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium
           RepID=HIS2_CLONN
          Length = 110

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 29/95 (30%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 + +L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   ++ +
Sbjct: 1   MDNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDD 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  D++YH++VL+ ++ + L  +   L KR +
Sbjct: 61  LIAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95


>UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales
           RepID=HIS2_BORA1
          Length = 116

 Score =  106 bits (266), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 28/74 (37%), Positives = 38/74 (51%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP+TSY AKL A G     +K+GEE  E  +AA       + +E +DL +H LV L    
Sbjct: 29  DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88

Query: 189 LDLTTVIENLRKRH 202
           L    V+  L +R 
Sbjct: 89  LRPEDVLAELARRE 102


>UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria
           RepID=HIS2_MAGSA
          Length = 109

 Score =  106 bits (265), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 42/92 (45%), Positives = 56/92 (60%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +L  ++A RK  DP+ SYTAKL+A G  +IAQK GEE VET +AA    + EL
Sbjct: 3   QDSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDEL 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++D +YHLLVL  D G++   V   L +R
Sbjct: 63  VGESADTLYHLLVLWADCGVEPAKVWAELARR 94


>UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria
           RepID=HIS2_NITMU
          Length = 121

 Score =  106 bits (265), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 34/94 (36%), Positives = 49/94 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 L++L + +  RK +DP  SY AKL   G  +I +K+ EE  E  LA+   D   
Sbjct: 1   MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  E +DL +H LVLL    L L  V++ LR+R 
Sbjct: 61  VVRETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94


>UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZNB1_9GAMM
          Length = 125

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 31/83 (37%), Positives = 50/83 (60%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            +++ +R+ ADPE SY AKL+A G   + +K+GEE  ET +A    D   L +E +DL +
Sbjct: 19  AEVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGKNDDSDALVSEMADLWF 78

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L++L  +G     V++ L +R
Sbjct: 79  HSLIVLAARGRHPDDVLDELARR 101


>UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms
           RepID=HIS2_ALHEH
          Length = 109

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 33/83 (39%), Positives = 47/83 (56%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            ++L ER+ ADP TSY AKL+  G   I +KVGEE  E  +AA   DR ++  E +DL +
Sbjct: 12  AEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVIYETADLWF 71

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L++L         V+  L +R
Sbjct: 72  HSLIMLSACDAGPDDVLAELERR 94


>UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria
           RepID=HIS2_NEIG1
          Length = 107

 Score =  105 bits (262), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 31/85 (36%), Positives = 47/85 (55%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           ++Q + +RKSADP  SY A+L   G  +I +KV EE  E  +A+   D   L  E +DL 
Sbjct: 9   IQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHLVYEVADLW 68

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           +H ++LL    L    V++ L +R 
Sbjct: 69  FHTMILLTHHDLKAEDVLDELSRRQ 93


>UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum
           ATCC 11170 RepID=HIS2_RHORT
          Length = 117

 Score =  104 bits (261), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 36/89 (40%), Positives = 52/89 (58%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L  ++A R+ ADP TSYTAKL+  G  +I QK GEE  E  +AA V    ++  E
Sbjct: 15  EIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAE 74

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           ++D++YHL+VL  D G+    V   L +R
Sbjct: 75  SADVLYHLMVLWADVGVTPDRVWAELARR 103


>UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KWI3_HALNC
          Length = 124

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 44/94 (46%), Positives = 60/94 (63%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
           T +    L QL  ++ +RK ADP +SY A+L+A G  +IAQKVGEEGVE ALAA   D  
Sbjct: 3   TNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDNV 62

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            + +E +DL +H +VLL D GL    V++ L +R
Sbjct: 63  AIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96


>UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria
           RepID=HIS2_GRABC
          Length = 160

 Score =  104 bits (259), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 35/96 (36%), Positives = 56/96 (58%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR 166
           D  +    L +L +++ +R+ ADP  S++A+L + G  ++AQK GEE VE  + A   D+
Sbjct: 38  DPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIEAVSGDK 97

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             L  E++D++YHLLVL    G++   V   L KR 
Sbjct: 98  EALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133


>UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei
           group RepID=HIS2_LACCB
          Length = 110

 Score =  103 bits (258), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 29/93 (31%), Positives = 45/93 (48%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                +  L   + ER++     SYT  L+  G  +I +KVGEE  E  +AA   D    
Sbjct: 3   QAKQSIPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPAF 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             E +DL YH+LVL+ ++G+ +  +   L  R 
Sbjct: 63  ILEVADLTYHVLVLMVERGITVDQIATELASRE 95


>UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales
           RepID=B0MMD1_9FIRM
          Length = 114

 Score =  103 bits (258), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 37/99 (37%), Positives = 58/99 (58%), Gaps = 5/99 (5%)

Query: 110 HQWLFLYQLEQLLAERKS-----ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
            +     ++ +++  RK+       PE SYT  L+  G  +I +KVGEE  ET +AA   
Sbjct: 1   MKMTVYEEIFEVIKARKAQYDAGNAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNA 60

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           D  EL NE +DL+YH++VL  D+GL+ + V E L +R++
Sbjct: 61  DNDELKNEINDLLYHVMVLCADRGLEWSEVEEVLSERNE 99


>UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=A4EBZ9_9ACTN
          Length = 105

 Score =  103 bits (257), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 31/103 (30%), Positives = 49/103 (47%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G  +      +    L  L +++  R+ A P+ SYTA+L       + +K+ EE  E  +
Sbjct: 2   GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61

Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A   +D   +  EA DL+YHLLV L+  G+ L  +   L  R 
Sbjct: 62  ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARR 104


>UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria
           RepID=HIS2_ACICJ
          Length = 133

 Score =  103 bits (257), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 36/110 (32%), Positives = 56/110 (50%), Gaps = 1/110 (0%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGE 152
           +G   H          A     L +L   +  RK+ADP  S++A+L + G  ++AQK GE
Sbjct: 1   MGAASHPPV-PLLNPAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGE 59

Query: 153 EGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           E VE  + A   +R  L  E++D++YHLLV+    G+    V   L++R 
Sbjct: 60  ESVECLIEAVAGNRTALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109


>UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis
           RepID=HIS2_ZYMMO
          Length = 107

 Score =  103 bits (257), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 43/93 (46%), Positives = 57/93 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  +E ++AER+ A PE SY + L+  GT  IAQKVGEE VET +AA   D+  L
Sbjct: 1   MSEETLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +EA+DL++HL VLL D+G     V   LR+R 
Sbjct: 61  ESEAADLIFHLAVLLADRGSSFENVFSELRRRE 93


>UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales
           RepID=HIS2_LEUMM
          Length = 114

 Score =  103 bits (257), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 1/92 (1%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +   ERK      SYT  LY  G  +I +KVGEE  E  L A  ++  EL
Sbjct: 1   MPQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EEL 59

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E SDL++HL+VLL ++G+ L  + + L  R
Sbjct: 60  IYETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91


>UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BVA1_9PROT
          Length = 104

 Score =  103 bits (256), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 36/90 (40%), Positives = 59/90 (65%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
              L +L+QL+  +K +DP  SYTAKL++ G + I +K GEE +E  +A+   ++  + N
Sbjct: 1   MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           E++D++YHLLVLL ++ + L  VI  L +R
Sbjct: 61  ESADVLYHLLVLLSEKSVTLKEVISELERR 90


>UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria
           RepID=HIS2_HALHL
          Length = 114

 Score =  102 bits (255), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 29/83 (34%), Positives = 48/83 (57%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + + +R+ A  +TSY A+L+  G   I +KVGEE  E  +AA   +R ++  E +DL +
Sbjct: 18  AETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYETADLWF 77

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H LV+L   G+ +  V+  L +R
Sbjct: 78  HTLVMLSASGVSVDEVLAELERR 100


>UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM
           10642 RepID=C8SBH0_FERPL
          Length = 92

 Score =  102 bits (255), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
            L +L++++ ERK      SYTAKL     G  ++ +K GEE VE  LA    D+  +  
Sbjct: 1   MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EA+DL+YH +VLL    + +  V + LR+R +
Sbjct: 61  EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92


>UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1
           Tax=Raoultella terrigena RepID=Q6U8A9_KLETE
          Length = 88

 Score =  102 bits (255), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 70/82 (85%), Positives = 74/82 (90%)

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           LAERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL+
Sbjct: 7   LAERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHLM 66

Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203
           VLLQDQ L L  +I NL+ RHQ
Sbjct: 67  VLLQDQELSLQDIIANLKSRHQ 88


>UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria
           RepID=HIS2_ACIAC
          Length = 137

 Score =  102 bits (254), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 33/112 (29%), Positives = 47/112 (41%), Gaps = 7/112 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSA---DPETSYTAKLYASGTKRIAQKVGEEG 154
           H   S       H    L +L  ++  RK A   D + SY A+L   G     +K+GEE 
Sbjct: 3   HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62

Query: 155 VETALAATVHDRFE----LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            E  +AA   D       L  E +DL +H ++ L   GL    V+  L +R 
Sbjct: 63  TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114


>UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=HIS2_UNCMA
          Length = 95

 Score =  102 bits (254), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            ++  ++A+RK    E SYT  LY    G  ++ +K+GEE  E  +AA      E+ +E 
Sbjct: 6   DEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIVSEC 65

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +DL +H +VLL  + +    + E   +R +
Sbjct: 66  ADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95


>UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SM22_9BACT
          Length = 100

 Score =  101 bits (252), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 28/92 (30%), Positives = 51/92 (55%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +++ ERK+   + SYT +L   G+ +I +K+GEE  E   A    D  ++
Sbjct: 1   MNVEIIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E +DL+YHL+V L+ + +    V+  L++R
Sbjct: 61  AGETADLLYHLIVALEFRNVQFEDVLGVLQER 92


>UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria
           RepID=HIS2_MAGSM
          Length = 252

 Score =  101 bits (251), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 39/99 (39%), Positives = 52/99 (52%), Gaps = 2/99 (2%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
                     L Q+ Q++ +RKSA DPE SY AKL+  G   I +KVGEE  E  LA   
Sbjct: 3   NLSPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKG 62

Query: 164 H-DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              R E+ +EA+DL++H LV L    +  T V+  L  R
Sbjct: 63  RAARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101


>UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria
           RepID=HIS2_BURCC
          Length = 121

 Score =  101 bits (251), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 29/85 (34%), Positives = 41/85 (48%), Gaps = 4/85 (4%)

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV----HDRFELTNEASDLM 177
           +  RK  DP+ SY ++L+  G   + +K+GEE  E  LAA           L  E +DL 
Sbjct: 16  IDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQGGAPTALVGEVADLW 75

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           +H LV+L    L    VI  L +R 
Sbjct: 76  FHCLVMLSHFDLSPADVIAELERRE 100


>UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria
           RepID=HIS2_NITWN
          Length = 116

 Score =  100 bits (249), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 36/96 (37%), Positives = 51/96 (53%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
                Q   ++ L  ++  R ++  + SYT KL   G    A+K+GEE VET +AA   D
Sbjct: 6   SRRIMQRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAAVEKD 65

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           R  L  E +DLM+H LVLL+  G+ L  V   L +R
Sbjct: 66  RHHLIAEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101


>UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales
           RepID=HIS2_METB6
          Length = 104

 Score =  100 bits (249), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGV 155
           H+G              + +L  ++ ER     E SYT++L     G  ++ +KVGEE  
Sbjct: 3   HEGKEPV------DLRVIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEEST 56

Query: 156 ETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           E  LA         T EA+DL +H+LV L+   +DL+ VI  L +R +
Sbjct: 57  EFILAVKNGVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104


>UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei
           RepID=HIS2_IGNH4
          Length = 102

 Score =  100 bits (249), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 34/91 (37%), Positives = 54/91 (59%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
            FL +L  ++ +R    P+ SYTA++   G    A+K GEE VE  +A+    R  +  E
Sbjct: 3   DFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D++YHL+VLL  +G+D   VI+ L +R +
Sbjct: 63  AADVIYHLMVLLALRGVDWAEVIKELERRSR 93


>UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ
          Length = 127

 Score =   99 bits (248), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 37/103 (35%), Positives = 53/103 (51%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
                   +       L +L  L+  R+S   + SYTA+L  +G +R A+K GEE VET 
Sbjct: 8   SSAPPRDKEFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETV 67

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +AA   D   L  EA+D +YHLLVLL+ + +    V+  L  R
Sbjct: 68  IAALGSDASALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110


>UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae
           RepID=HIS2_METBF
          Length = 104

 Score = 99.2 bits (246), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 51/90 (56%), Gaps = 2/90 (2%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            ++ +++ +RK    E SY  KL     G  +I +KVGEE +ET LA    +  E+ +E+
Sbjct: 10  NRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNENHEEIVSES 69

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           SDL++HLLV+L    + L  +   L  RH+
Sbjct: 70  SDLIFHLLVMLAANNVTLDEIAAELSARHE 99


>UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing
           symbionts RepID=HIS2_VESOH
          Length = 105

 Score = 97.6 bits (242), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 29/83 (34%), Positives = 46/83 (55%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQ+L +RKSA  + SY + LY  GT  I +K+ EE  E  +A       ++  E +DL +
Sbjct: 9   EQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYEIADLWF 68

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H LVLL+ + + +  +   L +R
Sbjct: 69  HTLVLLRFKKIKVEQITNELSRR 91


>UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria
           RepID=HIS2_BRUA1
          Length = 107

 Score = 97.3 bits (241), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  LE+++AER S    TSYTA L A G  + AQK+GEE VET +AA   DR  +
Sbjct: 1   MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +E++DL+YHL V+    G+ L  V++ L++R
Sbjct: 61  VSESADLLYHLAVVWNIAGVALEDVLQELQRR 92


>UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum
           hungatei JF-1 RepID=Q2FUB9_METHJ
          Length = 91

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 50/90 (55%), Gaps = 2/90 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + ++  ++ ER +   E SYT+K+     G  +  +K+GEE  E  +A    D+  ++ E
Sbjct: 1   MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL++H ++ L+  G+ L +V + L+ R 
Sbjct: 61  GADLLFHFMLALKRSGVTLQSVWDELQSRR 90


>UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TJZ9_9PROT
          Length = 104

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 50/91 (54%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             + +L + +   ++  P  S TA+L   G  +IA+KV EE  E AL A V DR  +  E
Sbjct: 3   HPIDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           ++DL+Y+L+VL    G+  + V   + +R +
Sbjct: 63  SADLLYNLMVLWVWMGITPSEVWAEMEQREK 93


>UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae
           RepID=HIS22_BRAJA
          Length = 134

 Score = 95.7 bits (237), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 26/87 (29%), Positives = 45/87 (51%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            +L   +   +  DP TS TA+L+  G  ++A+K+ EE +E  + A   D   +  E++D
Sbjct: 6   ERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRESAD 65

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202
           L+Y+L VL    G+    V   + +R 
Sbjct: 66  LLYNLTVLWASAGVRPEDVWREMTRRE 92


>UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales
           RepID=HIS2_MESSB
          Length = 112

 Score = 95.7 bits (237), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 36/92 (39%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE ++AER ++    S+TA+L ++G  + A+K+GEE VET +AA   D+  L
Sbjct: 1   MNEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKAL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++DL+YH LV+L+  G+ L  V+  L  R
Sbjct: 61  IAESADLVYHWLVVLKIAGVRLDEVMLELESR 92


>UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis
           HTCC2503 RepID=A3VQS9_9PROT
          Length = 109

 Score = 95.7 bits (237), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 37/87 (42%), Positives = 47/87 (54%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            +L   +  RK AD   SYTA L   G  R A+K GEE VE ALA  +  R +L  E +D
Sbjct: 9   ERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAETAD 68

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++YHL VLL    LD + +   L KR 
Sbjct: 69  VLYHLAVLLAANELDWSDISAALTKRE 95


>UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae
           RepID=A4SV22_POLSQ
          Length = 133

 Score = 94.9 bits (235), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%)

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV--------HDRFELTNEASDLMY 178
           SADP+TSYTA L++ G   I +K+GEE  E  +AA            +  L  E +DL +
Sbjct: 33  SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L+ L    L    VI  L +R
Sbjct: 93  HCLIALSQFNLRPEDVIAELDRR 115


>UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae
           RepID=Q2CDY7_9RHOB
          Length = 106

 Score = 93.4 bits (231), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 34/83 (40%), Positives = 50/83 (60%), Gaps = 1/83 (1%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + +A RK ADP+ S+TA+L AS  +  A+K GEE VE  + A   DR  L +EA+D++Y
Sbjct: 7   AETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSEAADVIY 65

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           HLLV+     + L  +   L +R
Sbjct: 66  HLLVMCAVNDITLADIERELERR 88


>UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp. HTCC2601
           RepID=Q0FX88_9RHOB
          Length = 164

 Score = 93.0 bits (230), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 39/135 (28%), Positives = 54/135 (40%), Gaps = 6/135 (4%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGLMP     A SGE+LMLG+M  EA   T+E+G+  +FSR +Q LW +G  SG  L +
Sbjct: 12  PDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQVLWHEGAASGLVLKL 71

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSY 134
           V        D  L      G   H  + +       +             R    P  S 
Sbjct: 72  VEARI---EDAQLRANRSRGR--HSKSDNHMYYKRRRAAGCPPSYFDRTGRDMKAP-NST 125

Query: 135 TAKLYASGTKRIAQK 149
           +       +  I+ K
Sbjct: 126 SGPAMKKASPGISAK 140


>UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae
           RepID=HIS2_NATPD
          Length = 101

 Score = 93.0 bits (230), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 38/98 (38%), Positives = 55/98 (56%), Gaps = 2/98 (2%)

Query: 107 DTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVH 164
           D       L +L +++  RK   P+ SYTA L+    G   + +K+GEE  E  LAA   
Sbjct: 4   DGHDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDD 63

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           D  EL +EA+D++YHLLVLL  + ++L  +   LRKR 
Sbjct: 64  DDEELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101


>UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis
           RepID=HIS2_SPHAL
          Length = 109

 Score = 91.9 bits (227), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 37/85 (43%), Positives = 51/85 (60%), Gaps = 1/85 (1%)

Query: 119 EQLLAERKSADP-ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           E ++ +R +A   E SY A L A G  +IAQK+GEE VE  +AA   D   L  EASDL+
Sbjct: 13  EAVIHDRLAAGEAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGEASDLV 72

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           +HL +LL ++GL    +   L +RH
Sbjct: 73  FHLSILLAERGLTWDAIAAELDRRH 97


>UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota
           RepID=HIS2_META3
          Length = 96

 Score = 91.5 bits (226), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 4/96 (4%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRF 167
              L +  +++ +R    PE SY A L  +       +I +KVGEE  ET LAA   D+ 
Sbjct: 1   MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ 60

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EL  E++DL++H+LVLL + G++   ++E   +R +
Sbjct: 61  ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK 96


>UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K
           RepID=B4UDK1_ANASK
          Length = 110

 Score = 89.6 bits (221), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 43/90 (47%), Gaps = 6/90 (6%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNE 172
              + + R  A P  SYT KL A+   RI +K+ EE  E   A          +  L +E
Sbjct: 11  WATIESRRADAAPAESYTKKLLAA-PARIRRKIIEEAYEVNEAHQALLDGKDTKDHLAHE 69

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A+DL+YHL VLL    +  T V   L +RH
Sbjct: 70  AADLLYHLYVLLASADVTPTEVYGVLERRH 99


>UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae
           RepID=Q0C645_HYPNA
          Length = 120

 Score = 88.8 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 31/104 (29%), Positives = 45/104 (43%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
              +             +  E + A     D  +S+TAKL A G    A KV EEG E A
Sbjct: 2   TAKAPLASPDRLAAALAHLAETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELA 61

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            A        + +EA+D++YH+ V L+ +G+ L  V   L  R 
Sbjct: 62  DAVRRESDDRVASEAADVIYHVFVALRSRGVALDAVAGALEARQ 105


>UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces
           RepID=HIS2_STRCO
          Length = 90

 Score = 87.2 bits (215), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 26/76 (34%), Positives = 39/76 (51%)

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +  + DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V
Sbjct: 15  HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74

Query: 183 LLQDQGLDLTTVIENL 198
           ++  +G+ L  V  +L
Sbjct: 75  MMVARGISLDDVYAHL 90


>UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB
          Length = 101

 Score = 87.2 bits (215), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
            L   + +RK+ D + SYT+ L + G  +   K+ EE  E   A   +D+  + +EA+D 
Sbjct: 7   NLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHEAADT 64

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +YH+LV L+   +    V++ L  R +
Sbjct: 65  IYHILVTLEAADIKFEDVLKELEGRKK 91


>UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani
           RepID=HIS2_CLOTE
          Length = 107

 Score = 86.5 bits (213), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
            +   L +    + + +  D   SY   L+   + +I +K+GE+  E  +A     + E 
Sbjct: 1   MEVNKLIEELVEVIKDRKNDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQ 57

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +E SDL+Y+L+VL+  Q +++  VIE L KR 
Sbjct: 58  VHEISDLIYNLMVLMMKQNIEIENVIEELGKRR 90


>UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales
           RepID=HIS2_STRGG
          Length = 90

 Score = 86.5 bits (213), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 26/75 (34%), Positives = 38/75 (50%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +    DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V+
Sbjct: 16  KAAEGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVM 75

Query: 184 LQDQGLDLTTVIENL 198
           +  +G+ L  V  +L
Sbjct: 76  MVARGISLDDVYAHL 90


>UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria
           RepID=Q4JVP0_CORJK
          Length = 332

 Score = 84.5 bits (208), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 27/91 (29%), Positives = 38/91 (41%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
              +      L   L+ R    PE S T K   +G     +K+ EE  E  LAA      
Sbjct: 242 NEQELKTFDSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDE 301

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           EL  E S L+Y L V++  +GL    + + L
Sbjct: 302 ELAEEISQLLYWLQVVMVGRGLTPADIYKYL 332


>UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RQ70_FIBSS
          Length = 86

 Score = 83.8 bits (206), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           +   ++  L  +RK   PE   T +L+  G   I +K+ EE  E+ +AA    R     E
Sbjct: 1   MTFEEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S ++Y++ V++ ++GL L  V   L
Sbjct: 61  LSQVLYYVAVMMAEKGLTLEEVYAKL 86


>UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD
          Length = 253

 Score = 82.6 bits (203), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 30/79 (37%), Positives = 49/79 (62%)

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + + +S +   S+T K+ A G  +I +KVGEE VE  LA    D   + +EA+D++YH+L
Sbjct: 57  ITKAQSLETAKSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHVL 116

Query: 182 VLLQDQGLDLTTVIENLRK 200
           +LL   GL L T+ + +R+
Sbjct: 117 LLLVAMGLSLNTLFDVIRR 135


>UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium
           HIMB114 RepID=D0RQN9_9RICK
          Length = 103

 Score = 81.5 bits (200), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 28/83 (33%), Positives = 46/83 (55%), Gaps = 3/83 (3%)

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + + ERK++    SYT KL  +      +KV EE  E   A   +++    +EA+D+MYH
Sbjct: 10  KTIRERKNSSEHESYTKKLLDNN-SLCREKVMEEIKELVEAL--NEKKNEVHEAADVMYH 66

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVLL+   + +  V+  L+KR 
Sbjct: 67  ILVLLEANNVKVEDVMNELKKRE 89


>UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus
           Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK
          Length = 90

 Score = 80.7 bits (198), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  L +L  +RKS+  E SYT KL          KV EE  E   A   +      +E
Sbjct: 3   NTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--IHE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D+ YHLL+ L+   + +  V++ L  R +
Sbjct: 60  AADVFYHLLMYLEANDVKIEEVMQELENRKK 90


>UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium
           RepID=C4L178_EXISA
          Length = 102

 Score = 79.9 bits (196), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +++LEQL+  RK    E SYT  L+  G ++IA+K GEE  E  +AA      +L  E+
Sbjct: 1   MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL+YHLLVLL  +G+ L  V   L KRH
Sbjct: 59  ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87


>UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria
           RepID=HIS2_MYCLB
          Length = 93

 Score = 79.2 bits (194), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 27/86 (31%), Positives = 35/86 (40%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                L   L+ER    P  S T      G   + +K+ EE  E  LAA    +  L  E
Sbjct: 8   KTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEE 67

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S L+Y   VL+  +GL L  V   L
Sbjct: 68  ISQLLYWTQVLMISRGLSLDDVYRKL 93


>UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae
           RepID=HIS2_METS3
          Length = 96

 Score = 78.8 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%), Gaps = 6/86 (6%)

Query: 121 LLAERKSADPETSYTAKLYA----SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
            + E +  +P  SYT+K+          +I +KV EE  E  LAA       L  E+ DL
Sbjct: 12  KVLEERRDNPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND--ENLVYESVDL 69

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++H L++L  +G+++  + E   +R 
Sbjct: 70  IFHTLLILVYKGIEIDEIFEEFARRR 95


>UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae
           RepID=HIS2_METS5
          Length = 93

 Score = 78.8 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 37/88 (42%), Positives = 54/88 (61%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            +L  ++A+R    PE SYTA L   G   +A+KVGEE VE  +A+    R  + +E +D
Sbjct: 6   EELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSETAD 65

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+YHLLVLL  +G+ L  V + LR+R +
Sbjct: 66  LIYHLLVLLAMEGISLDEVRDELRRRMK 93


>UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae
           RepID=HIS2_RHOBA
          Length = 120

 Score = 78.4 bits (192), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 33/90 (36%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNE 172
            +L   L  R +  PE SYT KL   G + I +K+ EE  E   AA   D   R     E
Sbjct: 9   DRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHAIYE 68

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A DL+YH +VL+  +G++L  V   L +R 
Sbjct: 69  AGDLIYHAMVLMAWRGIELDEVAAELARRE 98


>UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis
           RepID=B9RGV5_RICCO
          Length = 193

 Score = 78.4 bits (192), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 26/105 (24%), Positives = 46/105 (43%), Gaps = 7/105 (6%)

Query: 103 SCFGDTAHQWLFLYQLEQLLAERKS---ADPET--SYTAKLYASGTKRIAQKVGEEGVET 157
                       LY LE  +++RK+   A  E   S+T +L       +  K+ EE  E 
Sbjct: 74  GAVQGKRLALTTLYSLESTISQRKAELAAPQEGKPSWTRRLL-DDPNLLCSKIREEADEL 132

Query: 158 ALAATVHDRF-ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                 ++      +E  D++YH +VLL  + + +  V++ LR+R
Sbjct: 133 CRTLEENEHSIHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177


>UniRef50_C0GPL2 Type III restriction protein res subunit n=1
           Tax=Desulfonatronospira thiodismutans ASO3-1
           RepID=C0GPL2_9DELT
          Length = 978

 Score = 76.5 bits (187), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 19/106 (17%), Positives = 40/106 (37%), Gaps = 7/106 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVET 157
           H  +   +     +         ++ E+      +S + + +        QK+ EE  E 
Sbjct: 4   HSNSHPIYYYKLVRDKIPS----IIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYEL 56

Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             A    D+  +  E+SD++   L +L+ Q      ++  L KR +
Sbjct: 57  FTAIANGDKESVLKESSDVLEITLTILKQQNYSFDDLLAELEKRRE 102


>UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZIN5_PLALI
          Length = 98

 Score = 76.1 bits (186), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 3/86 (3%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTNEASD 175
           E  L  R    P  SY  +L  +G   +A  + E+  +   A    D     ++   A++
Sbjct: 9   EAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPAAAAN 68

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           +++H ++LL+  G DL+TV   L +R
Sbjct: 69  VLFHWMLLLKAYGHDLSTVERELMQR 94


>UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales
           RepID=Q0F926_9RHOB
          Length = 105

 Score = 75.3 bits (184), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 31/84 (36%), Positives = 53/84 (63%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            Q +  RK+   E SY ++L  SG+++ A+K GEE VE  +AA   D+  LT E++D+++
Sbjct: 9   AQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEESADVLF 68

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           H+LV+L    +D  +V++ L +R 
Sbjct: 69  HMLVMLSSCDVDFKSVLKELERRE 92


>UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WMR5_EGGLE
          Length = 163

 Score = 74.9 bits (183), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 34/134 (25%), Positives = 48/134 (35%), Gaps = 35/134 (26%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
           S     ++        L   +A R+ A  E SYT +L       + +KV EE  ETALAA
Sbjct: 9   SGEMPPSSQIGATFEALAATIAARREAG-EESYTYRLLTGSLDGVLKKVMEEAGETALAA 67

Query: 162 TVHDR----------------------------------FELTNEASDLMYHLLVLLQDQ 187
              +                                     L  EA+D++YHLLV+L+  
Sbjct: 68  KDVESWACSSLAASIAASGAVDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERY 127

Query: 188 GLDLTTVIENLRKR 201
           G+ L      L  R
Sbjct: 128 GIGLDEFAAELNNR 141


>UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U6I7_HYDS0
          Length = 251

 Score = 62.6 bits (151), Expect = 8e-09,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 32/71 (45%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
               + +A+ V EE  E   A    D+  +  E +DL+    +H  +  +++  D+  V 
Sbjct: 24  KQTHESLAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVF 83

Query: 195 ---IENLRKRH 202
              I+ L +RH
Sbjct: 84  ELLIKKLVERH 94


>UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GIZ4_9FIRM
          Length = 481

 Score = 61.8 bits (149), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D  +L  E  DL+    +H  +  ++Q      ++
Sbjct: 250 EQDHHSLKPYLLEEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIV 309

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 310 AGITEKLVRRH 320



 Score = 40.2 bits (93), Expect = 0.044,   Method: Composition-based stats.
 Identities = 10/49 (20%), Positives = 20/49 (40%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            K+ EE  E   A    D  ++  E  DL++  + + +   +D    + 
Sbjct: 388 DKLAEELKELKDAYKEQDGAKIKEEMGDLLFAAVNVARFLDVDAEQALA 436


>UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RLE1_FIBSS
          Length = 265

 Score = 61.0 bits (147), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
              T  +   + EE  E   AA   D+  +  E  D++    +H  V  +     +  VI
Sbjct: 26  QQTTHSLLPYLVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVI 85

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 86  QGLCEKMVRRH 96


>UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria
           RepID=HIS2_METS4
          Length = 107

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 59/92 (64%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  L++++  R +A P+ SYTAKL A+G  + A+K+GEE VE A+AA   DR  L
Sbjct: 1   MTAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +EA+D++YHLLV+L   G+ L  V+  L +R
Sbjct: 61  VSEAADVLYHLLVVLVGSGVALEDVMAELERR 92


>UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6
           Tax=Bacteria RepID=Q3AFK8_CARHZ
          Length = 479

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   V EE  E A A    D  +L  E  DL+    +H  +  ++       V+
Sbjct: 252 EQTHRSLLPYVLEEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVV 311

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 312 EGICEKLIRRH 322


>UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640_PELTS
          Length = 582

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D ++   E  DL+    +H  +  +++  D+  VI
Sbjct: 345 EQDHRTLKPYLLEEAYEVIEALDEEDMYKTCEELGDLLLQIVFHAQIAAENRHFDINDVI 404

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 405 AGISEKMIRRH 415


>UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide
           pyrophosphohydrolase domain fusion protein n=1
           Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT
          Length = 258

 Score = 60.3 bits (145), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A    D  EL +E  DL+    +H  +  +++   +  V 
Sbjct: 27  EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 87  QNISEKMIRRH 97


>UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ
          Length = 303

 Score = 59.5 bits (143), Expect = 7e-08,   Method: Composition-based stats.
 Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
               ++  KV EE  E A A    D   ++ E  DL++ +  L +  G+D  T +     
Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALRDGTA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264



 Score = 49.9 bits (118), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A     I     EE  E A A    D  +L +E  DL+    +H  +  +        V 
Sbjct: 48  AQSFATIVPYTIEEAYEVADAVARGDLRDLRDELGDLLLQVVFHARMAEEQGAFAFDDVA 107

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 108 RAIGDKLVRRH 118


>UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A3P2_NATTJ
          Length = 384

 Score = 59.1 bits (142), Expect = 9e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    +   +  E  DL+    +H  V  +     L  V+
Sbjct: 133 KQTHQTLKPYLIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVL 192

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 193 TKLKDKLITRH 203



 Score = 41.0 bits (95), Expect = 0.027,   Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 26/60 (43%), Gaps = 4/60 (6%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL----DLTTVIENLRKRHQ 203
           +KV EE  E   A    +  +L  E  D+++ L+ L +   +     L    E  R+R +
Sbjct: 292 EKVNEEFTELQDAYQQENWEKLEEEIGDIIFSLVNLARFFNISTEVSLERTNEKFRRRFR 351


>UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SG07_9BACT
          Length = 257

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVI 195
                 I     EE  E   A    D   +  E  D+ +H++   V+ +++G   +  V+
Sbjct: 26  EQNLLSIKNHFMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVL 85

Query: 196 EN----LRKRH 202
                 L +RH
Sbjct: 86  NEINEKLIRRH 96



 Score = 46.8 bits (110), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 11/60 (18%), Positives = 21/60 (35%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                  K  EE  E   A     + E+ +E  D+ + L+ L +   ++    +     R
Sbjct: 160 DMHGCMDKFNEEINEFKEAVATGSKDEIEHEMGDVFFSLINLSRFLKINPDEALRRANSR 219


>UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1PZU0_9BACT
          Length = 283

 Score = 58.7 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A       +L  E +DL    ++H  +  + +  D+  V+
Sbjct: 47  EQNHVTLKPYLVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVM 106

Query: 196 ----ENLRKRH 202
               + + +RH
Sbjct: 107 KLCLDKMMRRH 117


>UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D9Q9_9ACTN
          Length = 336

 Score = 58.3 bits (140), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 19/71 (26%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTV- 194
           A   + I + + EE  E   A    D   L  E  D++     H  + L +Q   L  V 
Sbjct: 55  AQTHESITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVC 114

Query: 195 ---IENLRKRH 202
               E L +RH
Sbjct: 115 HGLAEKLIRRH 125


>UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM
          Length = 264

 Score = 58.3 bits (140), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV 194
                  IA+   EE  E   +   +D   L  E  DL+YH+L    +  +        V
Sbjct: 28  LQQNFASIAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDV 87

Query: 195 I----ENLRKRH 202
           I      L +RH
Sbjct: 88  IQQLAAKLIRRH 99


>UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium
           longum DJO10A RepID=UPI00003932E2
          Length = 68

 Score = 58.0 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 15/33 (45%), Positives = 19/33 (57%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            V  ++ DCD D LLV  + +G  CH G  SCF
Sbjct: 19  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCF 51


>UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NET9_KYTSD
          Length = 144

 Score = 58.0 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVI 195
                 +A  V EE  E   A    D   L  E  DL++    H  +  +     +  V+
Sbjct: 32  EQTHASLAPFVLEEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVV 91

Query: 196 ENLR----KRH 202
             L     +RH
Sbjct: 92  AELEAKLLRRH 102


>UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X332_DESRD
          Length = 979

 Score = 58.0 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 15/105 (14%), Positives = 37/105 (35%), Gaps = 7/105 (6%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
            G+   +     +         ++ +        S + +          QK+ EE  E  
Sbjct: 5   SGSHPIYYHKLVRDKIPS----IIRDNDHQPTVLSLSGQDLTQAAS---QKLLEEAYELF 57

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
               V ++  +  E++D++  +L +L+  G     +I  +  R +
Sbjct: 58  TEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102


>UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1
           Tax=Streptococcus mutans RepID=Q8DTR6_STRMU
          Length = 61

 Score = 57.6 bits (138), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 15/46 (32%), Positives = 25/46 (54%)

Query: 157 TALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             + A   D+ E+ +E +DL+YHL V+L + G+    V   L+ R 
Sbjct: 1   MVIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46


>UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC0_DESHD
          Length = 493

 Score = 57.2 bits (137), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
                 +   + EE  E   A    D + L  E  DL+    +H  V  +        V 
Sbjct: 249 EQTHDSLKPYLIEESYEVLEAIEAQDMYNLAEELGDLLLQVVFHAQVAQEAGEFQFQDVL 308

Query: 195 ---IENLRKRH 202
              I+ + +RH
Sbjct: 309 KGIIDKMIRRH 319


>UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF
          Length = 289

 Score = 55.7 bits (133), Expect = 9e-07,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +     EE  E A A    D  ++  E  D++    +H  +  + Q  DL  V
Sbjct: 46  IKQTNHSLIPYAIEEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDV 105

Query: 195 I----ENLRKRH 202
           I      L +RH
Sbjct: 106 IYTLQSKLIRRH 117


>UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGC7_KOSOT
          Length = 256

 Score = 55.3 bits (132), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    +  E   E  DL+    +H  +  +     +  V+
Sbjct: 28  EQTHESLKPYLIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVV 87

Query: 196 ----ENLRKRH 202
               + L +RH
Sbjct: 88  ETLSDKLIRRH 98



 Score = 40.6 bits (94), Expect = 0.035,   Method: Composition-based stats.
 Identities = 12/52 (23%), Positives = 24/52 (46%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
              + + +KV EE  E   A    D+ ++  E  DL++ ++ L +   +D  
Sbjct: 157 ENLEDVTEKVEEEWSELMNAIKSGDKKKINEEFGDLLFSMVNLSRFIEVDPE 208


>UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepID=C8XKR8_NAKMY
          Length = 240

 Score = 55.3 bits (132), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 15/75 (20%), Positives = 27/75 (36%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQ----DQGLDL 191
                 + + + EE  E   A    DR  +  E  D    +++H  +  +      G D+
Sbjct: 34  EQTHASLVRYLLEECYELVEAVESGDRAAIREELGDVLLQVLFHARIAAETPRDQGGFDI 93

Query: 192 TTV----IENLRKRH 202
             V    +  L +RH
Sbjct: 94  DDVAGDLVAKLVRRH 108


>UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RA19_AMMDK
          Length = 495

 Score = 54.9 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 14/73 (19%), Positives = 25/73 (34%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAA--TVHDRFELTNEASDLM----YHLLVLLQDQGLDLTT 193
               + + + + EE  E   A      D   L  E  DL+    +H  +  +    +L  
Sbjct: 256 EQTHQSLKKYLLEETYEVLEAIDRVEEDPHNLCEELGDLLLQIVFHCQIAAEAGRFNLDD 315

Query: 194 VI----ENLRKRH 202
           V+      +  RH
Sbjct: 316 VVRSITRKMIARH 328


>UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX RepID=Q47SV3_THEFY
          Length = 246

 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 17/73 (23%), Positives = 28/73 (38%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQ--GLDLTT 193
               + +A+ + EE  ET       D   L  E  D++    +H  V  +    G  +  
Sbjct: 32  EQTHESLAKYLIEEAYETVETIERGDYDTLAEELGDVLLQVVFHARVAAERGPDGFTIDD 91

Query: 194 V----IENLRKRH 202
           V    I+ L +RH
Sbjct: 92  VADAIIDKLVRRH 104


>UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD
          Length = 396

 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 13/60 (21%), Positives = 24/60 (40%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +  K+ EE  E   A   +DR  + +E  D+++ L  L +  G      +    +R
Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234



 Score = 40.2 bits (93), Expect = 0.040,   Method: Composition-based stats.
 Identities = 13/75 (17%), Positives = 21/75 (28%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALA----ATVHDRFELTNEASDLM----YHLLVLLQDQGLDL 191
               + +   + EE  E        A          E  DL+    +H  +  +     L
Sbjct: 33  EQDLRSLRPYLLEEAFEVLEEMDRVAYGGSWRTFCEELGDLLFQIVFHAQLASELGEFSL 92

Query: 192 TTVI----ENLRKRH 202
             V     + L  RH
Sbjct: 93  ADVAKAIGDKLVSRH 107


>UniRef50_B3DW98 Predicted pyrophosphatase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DW98_METI4
          Length = 269

 Score = 54.1 bits (129), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               K +  ++ EE  E   A    D   +  E  D    +++H  +  +        ++
Sbjct: 41  EQTHKSLKSQLIEECYELLEAIDQEDPSSIKEELGDILLHVLFHAQIAQEAGKFSFWDIL 100

Query: 196 ----ENLRKRH 202
                 L +RH
Sbjct: 101 DNLSAKLIRRH 111



 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 23/57 (40%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
              +    K+ EE  E   A    +R ++  E  DL++  +   +  G+D    I+ 
Sbjct: 173 KDPQGPLSKMQEELDEIKEAYGEKNREKIKKEIGDLIFSAVNFSRMLGIDPEEAIKE 229


>UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=C9N950_9ACTO
          Length = 328

 Score = 53.7 bits (128), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTT 193
               + +A+   EE  E   A    DR EL  E  D++    +H  +  +DQ     +  
Sbjct: 140 QKTHQGLAKYAIEEAYELVEAIEDGDREELREELGDVLLQVVFHARIAQEDQEEPFGIDD 199

Query: 194 VIE----NLRKRH 202
           V       L  RH
Sbjct: 200 VAATIVEKLIHRH 212


>UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria
           RepID=A8I3U9_AZOC5
          Length = 283

 Score = 53.0 bits (126), Expect = 6e-06,   Method: Composition-based stats.
 Identities = 11/56 (19%), Positives = 25/56 (44%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + +  K+ EE  E + A        + +E  DL++ ++ L +  G+D    + 
Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALR 230



 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 27/72 (37%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +A    EE  E   A    D  +L +E  DL+    +H  +  +    ++  V
Sbjct: 28  LEQNFSTVAPYTIEEAYEVVDAIERGDLADLKDELGDLLLQVVFHARLAQEQGLFEMGDV 87

Query: 195 IE----NLRKRH 202
           +E     L +RH
Sbjct: 88  VEAITTKLIRRH 99


>UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9
          Length = 302

 Score = 53.0 bits (126), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
           +  + +  KV EE  E   A       E+  E  DL++ +  L +   +D    I     
Sbjct: 200 ADARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIRSTNA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264



 Score = 49.1 bits (116), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL----TTVIEN 197
           IA    EE  E A A T  DR +L +E  DL+    +H  +  ++   D       +   
Sbjct: 63  IAPYTIEEAYEVADAITREDRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVVEAITAK 122

Query: 198 LRKRH 202
           + +RH
Sbjct: 123 MIRRH 127


>UniRef50_Q0S4J7 Putative uncharacterized protein n=4 Tax=Nocardiaceae
           RepID=Q0S4J7_RHOSR
          Length = 288

 Score = 53.0 bits (126), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 22/131 (16%), Positives = 41/131 (31%), Gaps = 7/131 (5%)

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131
             V ++  +     +LV  +P  P            +          + L+   +  D  
Sbjct: 34  QGVRTLLTEAPGAAVLVSTDPDHP---TVREWVASGSRVIAAPKVPGDNLVEAAEVMDRL 90

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQ 187
            SY         + ++  + EE  E   A    +R +L  E  DL    ++H  +     
Sbjct: 91  WSYGGWEVTQTHRTLSHYLVEETYEVLDAIESSERADLREELGDLLLQVLFHSRIASASG 150

Query: 188 GLDLTTVIENL 198
             D+  V   L
Sbjct: 151 HFDVDDVAATL 161


>UniRef50_Q0A8N1 MazG family protein n=4 Tax=Proteobacteria RepID=Q0A8N1_ALHEH
          Length = 292

 Score = 52.6 bits (125), Expect = 7e-06,   Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
            A     IA    EE  E A A    D  +L +E  DL+    +H  +  ++       V
Sbjct: 51  LAQDFASIAPYTLEEAYEVAEAIRRGDMADLQDELGDLLLQVVFHARMAEEEGFFTFEDV 110

Query: 195 IE----NLRKRH 202
                  L +RH
Sbjct: 111 ARSISDKLVRRH 122



 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 13/68 (19%), Positives = 22/68 (32%), Gaps = 5/68 (7%)

Query: 141 SGTKRIAQKVGEEGVETALAATVH-DRFELTNEASDLMYHLLVLLQDQGLDLTTVIE--- 196
                   KV EE  E A              E  DL++  + L +   +D  T ++   
Sbjct: 189 DDPAGPLAKVREEADELAEEMAQGAGPERFEEELGDLLFATVNLARHLKVDPETAVQKAG 248

Query: 197 -NLRKRHQ 203
               +R +
Sbjct: 249 DKFERRFR 256


>UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces
           RepID=D1X3V9_9ACTO
          Length = 335

 Score = 52.6 bits (125), Expect = 8e-06,   Method: Composition-based stats.
 Identities = 22/108 (20%), Positives = 38/108 (35%), Gaps = 17/108 (15%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                     L  ++ +   R+       +T++    G   +A+   EE  E   A    
Sbjct: 122 GSYDLPGARLLDLVQVMDRIRRECP----WTSRKTHRG---LAKYAIEEAYELVEAIEDG 174

Query: 165 DRFELTNEASDLM----YHLLVLLQDQG--LDLTTV----IENLRKRH 202
           DR EL  E  D++    +H  +  +D      +  V    +E L  RH
Sbjct: 175 DRDELREELGDVLLQVVFHARIAEEDPDEPFAVDDVAGGLVEKLIHRH 222


>UniRef50_A8L147 MazG family protein n=4 Tax=Frankia RepID=A8L147_FRASN
          Length = 436

 Score = 52.6 bits (125), Expect = 9e-06,   Method: Composition-based stats.
 Identities = 16/73 (21%), Positives = 24/73 (32%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDL--TT 193
                 +A  + EE  E   A    D  EL  E  D    +++H  +  +  G       
Sbjct: 165 EQNHVSLAPYLLEEAYEAYQAIEDGDLAELREELGDVLMQVLFHARIAAESGGAGWDVDD 224

Query: 194 VI----ENLRKRH 202
           V       L +RH
Sbjct: 225 VAAGLTAKLIRRH 237


>UniRef50_B8HTG9 MazG family protein n=2 Tax=Chroococcales RepID=B8HTG9_CYAP4
          Length = 388

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 17/74 (22%), Positives = 25/74 (33%), Gaps = 12/74 (16%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL------QDQGLDLT 192
            A   + +   V EE  E   A    +   +  E  DL+  L V+L      +     L 
Sbjct: 128 LAQTPESLTPYVIEEAYEVVHAIREGEPAAIAEELGDLL--LQVVLQAQIASEQAHFSLR 185

Query: 193 TVI----ENLRKRH 202
            V       L +RH
Sbjct: 186 DVAQSISAKLIRRH 199



 Score = 42.6 bits (99), Expect = 0.008,   Method: Composition-based stats.
 Identities = 19/72 (26%), Positives = 31/72 (43%)

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
            E + TA L  +    +  K  EE  E   A   +D  +   E  DL++ L+ L +   L
Sbjct: 257 AEKAGTAGLDWTDISGVWDKFYEEFHEFQEALLQNDPVQQQAELGDLIFTLINLARWCQL 316

Query: 190 DLTTVIENLRKR 201
           +  T +E   +R
Sbjct: 317 NPITALEETYQR 328


>UniRef50_A9FF91 Putative uncharacterized protein mazG n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9FF91_SORC5
          Length = 284

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + V EE  E   A    DR EL  E  DL+    +   +   +       VI
Sbjct: 42  EQSFATLRRYVLEEACEVIDAIDGGDRKELCAELGDLLLQVVFQAELARAEGAFGPDDVI 101

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 102 AAICEKLVRRH 112



 Score = 41.0 bits (95), Expect = 0.022,   Method: Composition-based stats.
 Identities = 13/55 (23%), Positives = 21/55 (38%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
             +    KV EE  E   A    D   +  E  D+++ L  L +  G+D    + 
Sbjct: 178 DARGSRAKVDEELGELDRALDGGDSAAIEEELGDVLFALGNLARHAGVDAEGALR 232


>UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=Actinomycetales
           RepID=A4F800_SACEN
          Length = 334

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 12/68 (17%), Positives = 22/68 (32%), Gaps = 6/68 (8%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQG--LDLTT 193
                 + + + EE  E   A    DR  L  E  D    +++H  +  +       +  
Sbjct: 125 EQDHDTLRKYLVEETYELLDAIEQRDRDALREELGDVLLQVLFHARIAAEHDADPFGVDE 184

Query: 194 VIENLRKR 201
           V   L  +
Sbjct: 185 VAAELVSK 192


>UniRef50_C8WFT9 MazG family protein n=3 Tax=Zymomonas mobilis RepID=C8WFT9_ZYMMN
          Length = 273

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 19/71 (26%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A     IA    EE  E   A    D  EL NE  DL+    +H  +  +        V+
Sbjct: 38  AQNFLSIAPYAIEEAYEVVDAIEQQDMHELKNELGDLLLQVVFHSQMAAEKDLFTFDDVV 97

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 98  TAICEKMIRRH 108



 Score = 40.6 bits (94), Expect = 0.032,   Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 23/57 (40%), Gaps = 3/57 (5%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
           S T     K+ EE  E   A    DR  L  E  D+++ +    +  G+D    ++ 
Sbjct: 175 SDTAGPRAKIDEELAEVDNAT---DRENLIEEIGDVLFTVTTFARHHGIDAEQALKK 228


>UniRef50_C6QD16 MazG family protein n=6 Tax=Proteobacteria RepID=C6QD16_9RHIZ
          Length = 335

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + IA    EE  E A A    D  +L +E  DL+    YH  +  +        V
Sbjct: 32  LEQNFETIAPYAIEEAYEVADAIARRDLPDLKDELGDLLLQVVYHARLAEEQGAFAFGDV 91

Query: 195 I----ENLRKRH 202
           +      + +RH
Sbjct: 92  VEAITRKMIRRH 103


>UniRef50_C9XSA1 Putative bifunctional protein [include tetrapyrrole
           (Corrin/Porphyrin) methylase and nucleoside triphosphate
           pyrophosphohydrolase] n=7 Tax=Clostridium
           RepID=C9XSA1_CLODC
          Length = 491

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   V EE  E   A   +D  E+  E  D++    +H  +  ++   DL  V+
Sbjct: 261 KQTHQSLKNSVIEEAYELCNAIDNNDIDEMVEELGDVLLQVIFHCQIGNEEGYFDLKEVV 320

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 321 NGICKKLIHRH 331


>UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C338_SPHTD
          Length = 466

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 17/60 (28%), Positives = 21/60 (35%), Gaps = 8/60 (13%)

Query: 151 GEEGVETALAATVHDRFELTNEASDLM---Y-HLLVLLQDQGLDLTTVI----ENLRKRH 202
            EE  E   A    D   L  E  DL+   Y H  +  +     L  VI      L +RH
Sbjct: 271 IEEAYEVLEAIERDDAAALREELGDLLLQVYLHAQIAEEAGEFTLEDVIGDLSAKLVRRH 330


>UniRef50_B0CCR5 MazG family protein n=8 Tax=Cyanobacteria RepID=B0CCR5_ACAM1
          Length = 411

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 12/72 (16%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTV 194
                + +   + EE  ET  A        +  E  DL+  +     +  +     L  +
Sbjct: 133 LEQTPQSLTPYIIEEAYETIDAIQSGSTEAIAEELGDLLLQVVLQAQIACEQDQFSLEEI 192

Query: 195 IE----NLRKRH 202
            +     L +RH
Sbjct: 193 AQGITKKLIRRH 204


>UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699CB9
          Length = 128

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 5  QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39
          +   ++ W+  +GL+P I Q   +G++LM+ +MN 
Sbjct: 3  EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36


>UniRef50_C0QR38 MazG family protein n=4 Tax=Hydrogenothermaceae RepID=C0QR38_PERMH
          Length = 261

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I   + EE  E   A    D   +  E  DL+    +H  +   +   D+  V+
Sbjct: 32  EQTNQSIKNNLIEEAYELFEAIESDDDKAMVEELGDLLLQVVFHSQIKKDEGSFDINDVL 91

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 92  ENLKEKLIRRH 102


>UniRef50_Q04VW6 Pyrophosphatase n=6 Tax=Leptospira RepID=Q04VW6_LEPBJ
          Length = 296

 Score = 51.8 bits (123), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A   +D   L  E  DL+    +H  +  +    DL  V 
Sbjct: 56  EQDHQTLIPYLIEESQEVIEAILKNDDELLKEELGDLLFQVVFHARLAEERHSFDLGDVA 115

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 116 KSVSDKLIFRH 126


>UniRef50_B5JET8 MazG family protein n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JET8_9BACT
          Length = 267

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 13/72 (18%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +AQ + +E  E        D   +  E  D++    +H  + ++    D   V
Sbjct: 67  IEQDHQSLAQCLVDECSELLETIDKLDMDHMREELGDVLLQVVFHAQLAMEAGHFDFDAV 126

Query: 195 IEN----LRKRH 202
                  L +RH
Sbjct: 127 AAEINEKLVRRH 138


>UniRef50_Q7V9I6 Predicted pyrophosphatase n=1 Tax=Prochlorococcus marinus
           RepID=Q7V9I6_PROMA
          Length = 276

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 11/72 (15%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +     EE  E   A    +  +L  E  DL+     H  +  +++      +
Sbjct: 34  LKQNHTSLIPYAIEEAYEVCDAIRYGNDSDLIEELGDLLLQVVLHAQIANEEKRFCFDDI 93

Query: 195 IE----NLRKRH 202
            +     + +RH
Sbjct: 94  AQTAAEKMIRRH 105


>UniRef50_Q6G3M6 MazG protein n=1 Tax=Bartonella henselae RepID=Q6G3M6_BARHE
          Length = 273

 Score = 51.4 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 14/72 (19%), Positives = 27/72 (37%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +   + EE  E   A    +R +L +E  DL+    YH  +  ++       V
Sbjct: 28  IKQTFESLIPYMLEEVYEVIDAIERKNRTDLCDELGDLLLQVVYHATIAQEEGSFTFEDV 87

Query: 195 I----ENLRKRH 202
           +      + +RH
Sbjct: 88  VYAITSKMIRRH 99



 Score = 39.5 bits (91), Expect = 0.068,   Method: Composition-based stats.
 Identities = 12/54 (22%), Positives = 20/54 (37%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
            +   K+ EE  E   A       ++  E  DL + LL L     +D    ++ 
Sbjct: 178 HKFFAKIEEEINELKDAIKNDKTSDIEAEFGDLYFSLLNLALHLNIDSQKALKK 231


>UniRef50_A2CDV8 MazG family protein n=11 Tax=Cyanobacteria RepID=A2CDV8_PROM3
          Length = 332

 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +   + EE  E A A    D   L+ E  DL+     H  +  ++   +L  +
Sbjct: 87  LEQTHTSLIPCMLEEAHEVADAIRNGDDNHLSEELGDLLLQVVLHAQIANEEGRFNLEDI 146

Query: 195 IE----NLRKRH 202
                  L +RH
Sbjct: 147 ARSISAKLIRRH 158



 Score = 42.2 bits (98), Expect = 0.010,   Method: Composition-based stats.
 Identities = 13/53 (24%), Positives = 23/53 (43%)

Query: 149 KVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           KV EE  E   A    D+     E  D+++ L+ + +  GL+    +    +R
Sbjct: 234 KVQEEFEELKEAVEHEDQAHAQTELGDVLFTLVNVARWCGLNPEEGLAGTNQR 286


>UniRef50_Q3AVT5 MazG n=4 Tax=Cyanobacteria RepID=Q3AVT5_SYNS9
          Length = 270

 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +   V EE  E A A    D   L  E  DL+     H  +  +     L+ V
Sbjct: 30  LEQTHASLVPYVLEEAHEVADAIRHGDDAHLKEELGDLLLQVVLHAQIAKEGNRFALSDV 89

Query: 195 I----ENLRKRH 202
                  L +RH
Sbjct: 90  ADGINAKLIRRH 101



 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
                +  KV EE  E   A    D+     E  DL++ L+ + +  G+     +    +
Sbjct: 170 DDMAGVWAKVHEELDELKEAVISGDQSHAQEELGDLLFTLVNVARWCGIAPEEGLAGTNR 229

Query: 201 R 201
           R
Sbjct: 230 R 230


>UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frankia sp. CcI3
           RepID=Q2J4X9_FRASC
          Length = 116

 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 24/93 (25%), Positives = 34/93 (36%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
                      +L   LAE+       S T      G   + +K+ EE  E  +AA    
Sbjct: 24  SSNVSNLKTFDELFVELAEKWRRRTPGSGTVAALDQGVHHLGKKLVEEAAEAWMAAEHEG 83

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           R     E S L+Y   +L+   GL L  V  +L
Sbjct: 84  RGRAAEEISQLLYWSQLLMISLGLSLDDVYSHL 116


>UniRef50_C7MMP1 MazG family protein n=2 Tax=Coriobacteriaceae RepID=C7MMP1_CRYCD
          Length = 307

 Score = 51.0 bits (121), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 19/73 (26%), Positives = 29/73 (39%), Gaps = 12/73 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLTT 193
               + IA+ + EE  E   A    DR  L  E  D++  L V+LQ Q         +  
Sbjct: 46  KQTHESIAKNMLEEAFEAVAAIEEADRDHLIEELGDVL--LQVVLQAQIAADAGEFTIDD 103

Query: 194 VIE----NLRKRH 202
           V +     + +RH
Sbjct: 104 VAQAVNEKIIRRH 116


>UniRef50_A8ZVD0 MazG family protein n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZVD0_DESOH
          Length = 269

 Score = 50.6 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ----DQGLDLTTVI 195
               + +   + EE  E   A    D  ++  E  DL++H+L L          DL  V 
Sbjct: 35  EQTPRSMTVYLVEEVHELVDAIMEADPAKICEELGDLLFHILFLESIFRGRGDFDLQDVA 94

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 95  RISAEKMIRRH 105



 Score = 46.0 bits (108), Expect = 8e-04,   Method: Composition-based stats.
 Identities = 15/64 (23%), Positives = 27/64 (42%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT----TVIEN 197
            T  +  K+ EE  E   A   +D+  +T E  DL++ L+ L +   +         ++ 
Sbjct: 171 DTAGVMDKIKEEFAELEAAMAENDKAHVTEEVGDLLFSLVNLARFLRVHPETALADTVKK 230

Query: 198 LRKR 201
             KR
Sbjct: 231 FEKR 234


>UniRef50_A4J0R1 MazG family protein n=4 Tax=Clostridia RepID=A4J0R1_DESRM
          Length = 505

 Score = 50.6 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               K +   + EE  E   A      +++  E  DL+    +H  +  +++  ++  V+
Sbjct: 268 EQTHKSLKPYLIEETYEVLEALEQGQMYKICEELGDLLLQIVFHAQIASENKQFNMNDVV 327

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 328 QSITEKMIRRH 338


>UniRef50_B0SCK2 Pyrophosphatase n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SCK2_LEPBA
          Length = 290

 Score = 50.6 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E        D   L  E  DL+    +H  +  +    D   V 
Sbjct: 31  EQTHRSVIPHLLEETYEVVDTIEKGDDNHLKEELGDLLFQITFHSQLAKERGAFDFQDVA 90

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 91  SGVFQKLVYRH 101


>UniRef50_Q3Z619 MazG family protein n=5 Tax=Dehalococcoides RepID=Q3Z619_DEHE1
          Length = 264

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   K +   + EE  E   A    D      E  DL+    +H  +  + +  ++  VI
Sbjct: 31  AQTHKSMRDSLLEETYEVLEALDAEDTGRFCGELGDLLLQIVFHAEIGAEAKEFNMGDVI 90

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 91  EAINTKLIRRH 101


>UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3J2_SALRD
          Length = 281

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 16/61 (26%), Positives = 25/61 (40%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    D  EL  E  D    +++H ++  +     L  VI    + L +R
Sbjct: 56  LIEEAYEVVAAIDHGDWDELAEELGDVLLHVLFHAVIAEEGGRFTLADVIEAETDKLVRR 115

Query: 202 H 202
           H
Sbjct: 116 H 116


>UniRef50_B2TI15 MazG family protein n=5 Tax=Clostridium RepID=B2TI15_CLOBB
          Length = 488

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I   + EE  E   A    D   L  E  D++    +H  +  +D   ++  V+
Sbjct: 250 EQTHESIKNSLIEESYEVVDAINNEDDDSLIEELGDVLFQVVFHSSIGQEDGYFNINDVV 309

Query: 196 ----ENLRKRH 202
               + +  RH
Sbjct: 310 KAICDKMIYRH 320



 Score = 42.6 bits (99), Expect = 0.010,   Method: Composition-based stats.
 Identities = 11/56 (19%), Positives = 24/56 (42%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
                  +KV EE  E   A    ++ ++ +E  DL++  + + +  G+D    + 
Sbjct: 385 DDVSFAFEKVNEELKEVKDAYISENKEKIEDEIGDLLFSCVNVARFLGIDGEEALN 440


>UniRef50_B9XJR1 MazG family protein n=1 Tax=bacterium Ellin514 RepID=B9XJR1_9BACT
          Length = 223

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               K +     EE  E   A    D  E+  E  DL+    +H  +  +    +   V 
Sbjct: 28  EQDHKSLRWHAVEEVYELMDAIEAGDDHEMAEELGDLLLQVVFHCQMAQERGAFNFEKVA 87

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 88  RHLVDKLIRRH 98


>UniRef50_B5HJI9 Nucleoside triphosphate pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=B5HJI9_STRPR
          Length = 293

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 19/77 (24%), Positives = 29/77 (37%), Gaps = 14/77 (18%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVL------LQDQGL 189
               K +A+   EE  E   A    DR EL  E  D++    +H  +        +D+  
Sbjct: 104 QQTHKGLAKYGIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEGGPGEEDEPF 163

Query: 190 DLTTV----IENLRKRH 202
            +  V    +E L  RH
Sbjct: 164 SIDDVAGTIVEKLIHRH 180


>UniRef50_B0K4Q4 MazG family protein n=10 Tax=Clostridia RepID=B0K4Q4_THEPX
          Length = 495

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 8/61 (13%), Positives = 22/61 (36%), Gaps = 4/61 (6%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + + EE  E   A       ++  E  D++    +H  +  +    +   V+
Sbjct: 256 EQTHQSLEKYLVEESYELVDAIEKESEDKMVEELGDVLLQVVFHSQIAKERGTFNFGDVV 315

Query: 196 E 196
           +
Sbjct: 316 D 316



 Score = 41.8 bits (97), Expect = 0.016,   Method: Composition-based stats.
 Identities = 9/46 (19%), Positives = 20/46 (43%)

Query: 147 AQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
             KV EE  E        D+ ++  E  DL++ ++ + +   ++  
Sbjct: 396 LSKVYEELEELKEVYKGKDKEKIIEEVGDLIFAVVNVARFLDVEPE 441


>UniRef50_B9CMC9 Tetrapyrrole methylase family protein, MazG family protein n=1
           Tax=Atopobium rimae ATCC 49626 RepID=B9CMC9_9ACTN
          Length = 298

 Score = 49.9 bits (118), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVI 195
           A     I + + EE  E   A        L  E  D++     H  +   D G D+  V 
Sbjct: 59  AQTHDSITKNMIEEAYEAVEAIKEGSSEHLQEELGDVLEQVLLHSQIESDDGGFDIDGVC 118

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 119 RALNEKLVRRH 129


>UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LC99_MAGSM
          Length = 277

 Score = 49.9 bits (118), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 16/55 (29%), Positives = 25/55 (45%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            T  I  K+ EE  E A A   +DR     E  DL++ L+ L +   ++  T + 
Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233



 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 21/61 (34%), Gaps = 4/61 (6%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTVI 195
               + +     EE  E   A    D  EL  E  DL++H+     +  +     L  V+
Sbjct: 40  EQSFQSLLPYTLEEVYEVLHAVETQDHQELKKELGDLLFHIVFYSQIAAEANQFTLEQVV 99

Query: 196 E 196
            
Sbjct: 100 N 100


>UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae
           RepID=HIS2_PYRIL
          Length = 94

 Score = 49.9 bits (118), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 39/94 (41%), Positives = 54/94 (57%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE+++  R       SYT +LY+SG   +A+KVGEE VE A+AA    +  +
Sbjct: 1   MSCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRI 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             EA+DL+YHLLVLL   GL L  V   L +R +
Sbjct: 61  VEEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94


>UniRef50_A6LPK0 MazG family protein n=10 Tax=Clostridia RepID=A6LPK0_CLOB8
          Length = 483

 Score = 49.9 bits (118), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               K + + + EE  E   A    D   L  E  D++    +H  +  +D   D+  VI
Sbjct: 250 EQTHKSLKKALIEESYEVIDAIDQDDDNSLIEELGDVLLQVVFHASIGKEDGYFDIGDVI 309

Query: 196 E----NLRKRH 202
           E     +  RH
Sbjct: 310 EGICNKMISRH 320


>UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MG87_RHOM4
          Length = 283

 Score = 49.5 bits (117), Expect = 6e-05,   Method: Composition-based stats.
 Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A   +D  EL  E  DL+    +H ++  Q     L  VI    E L +R
Sbjct: 52  LIEEAYEVVSAIEENDWEELKRELGDLLLHVVFHSVMAEQAGRFTLKDVIETETEKLIRR 111

Query: 202 H 202
           H
Sbjct: 112 H 112


>UniRef50_Q1K0K7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Desulfuromonas
           acetoxidans DSM 684 RepID=Q1K0K7_DESAC
          Length = 235

 Score = 49.5 bits (117), Expect = 6e-05,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM---YHLLVLLQDQG-LDLTTV- 194
                 I + + EE  E   A   +   ++ +E  DL+   Y L  + ++ G  +L  V 
Sbjct: 33  KQTPDTIKKHLLEEAYEVLDAIDHNISEDICSELGDLLMQIYFLADIYEEAGQFELFDVS 92

Query: 195 ---IENLRKRH 202
                 L +RH
Sbjct: 93  EAIQAKLIRRH 103


>UniRef50_Q28PV1 MazG family protein n=8 Tax=Bacteria RepID=Q28PV1_JANSC
          Length = 265

 Score = 49.5 bits (117), Expect = 6e-05,   Method: Composition-based stats.
 Identities = 18/71 (25%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA    EE  E A A    D  EL  E  DL+    +H  +       D   V 
Sbjct: 31  EQTFASIAPYTIEEAYEVADAIERGDMAELQGELGDLLFQSVFHAQMAEDGGHFDFDDVA 90

Query: 196 E----NLRKRH 202
                 +  RH
Sbjct: 91  RAIGDKMIARH 101


>UniRef50_Q7D8Z6 Transcriptional regulator, MazG family n=3 Tax=Mycobacterium
           RepID=Q7D8Z6_MYCTU
          Length = 294

 Score = 49.5 bits (117), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 16/108 (14%), Positives = 34/108 (31%), Gaps = 12/108 (11%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G        + +   L     ++ + ++A P  S            + + + EE  E   
Sbjct: 41  GARLISAPDSQRGERLVDAVAMMDKLRTAGPWES------EQTHDSLRRYLLEETYELLD 94

Query: 160 AATVHDRFELTNEASDL----MYHLLVL--LQDQGLDLTTVIENLRKR 201
           A       +L  E  DL    ++H  +          +  V + L ++
Sbjct: 95  AVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRK 142


>UniRef50_C1TQS2 MazG family protein n=3 Tax=Synergistaceae RepID=C1TQS2_9BACT
          Length = 275

 Score = 49.5 bits (117), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 12/65 (18%), Positives = 24/65 (36%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE----N 197
           +   + EE  E   A    D   +  E+ DL+    +  ++  +     L  ++      
Sbjct: 36  LRPHIIEEAYELVDAVDNGDIAGICEESGDLLLQVVFIGVIAEESGDFSLADIVRSISDK 95

Query: 198 LRKRH 202
           L +RH
Sbjct: 96  LIRRH 100



 Score = 41.0 bits (95), Expect = 0.022,   Method: Composition-based stats.
 Identities = 12/45 (26%), Positives = 21/45 (46%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
            K+ EE  E   A    DR  +  E  D+++ ++ L +  G+D  
Sbjct: 174 DKIDEEIDEVKTAMESEDRLSMEEEIGDVLFSIVNLARRLGVDPH 218


>UniRef50_Q2JT55 MazG family protein n=4 Tax=Bacteria RepID=Q2JT55_SYNJA
          Length = 364

 Score = 49.5 bits (117), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 20/73 (27%), Positives = 28/73 (38%), Gaps = 12/73 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL------QDQGLDLTT 193
           A   + +   + EE  ET  A    D   +  E  DL+  L V+L      +    DL T
Sbjct: 116 AQTPESLTPYILEEAYETVAAIRAGDPAAIAEELGDLL--LQVVLQSQIFAERNHFDLET 173

Query: 194 VIE----NLRKRH 202
           V       L +RH
Sbjct: 174 VAARIADKLIRRH 186


>UniRef50_D2LXK4 MazG family protein n=2 Tax=Bacillus RepID=D2LXK4_BACS4
          Length = 494

 Score = 49.5 bits (117), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + + EE  E   A    +  +L  E  D++     H  +   +    +  VI
Sbjct: 254 EQTHESLKKYLIEEAYEVLDAIDKGNEDDLVEELGDVLLQVVLHSQIGEDNGIFSIDQVI 313

Query: 196 ENL----RKRH 202
           E L     +RH
Sbjct: 314 ETLTEKMIRRH 324



 Score = 40.2 bits (93), Expect = 0.038,   Method: Composition-based stats.
 Identities = 8/49 (16%), Positives = 20/49 (40%)

Query: 149 KVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
           K+ EE  E         + + + E  D+++  + + +  G+D    +  
Sbjct: 400 KLQEEIAEWFQELKEGTKQDASKELGDVLFAFVNIARFHGIDPEEALRQ 448


>UniRef50_B2UPD1 MazG family protein n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UPD1_AKKM8
          Length = 269

 Score = 49.5 bits (117), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E       +D  +L  E  D++    +H  +  +    D   V 
Sbjct: 37  EQTHHSLISNMIEEAYEVVDTIQRNDWTQLREELGDVLLQVVFHAEIAQEAGRFDFNDVA 96

Query: 196 EN----LRKRH 202
                 L +RH
Sbjct: 97  AEVSEKLVRRH 107



 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 16/67 (23%), Positives = 29/67 (43%), Gaps = 7/67 (10%)

Query: 141 SGTKRIAQKVGEEGVET--ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI--- 195
           +  +    KV EE  E    L+A   D   +  E  DL++ ++ L + +G+D  T +   
Sbjct: 170 ADAQGALDKVKEETAECGEILSAPEEDP-RVAEELGDLLFSVVNLCRKKGIDPETAMAGA 228

Query: 196 -ENLRKR 201
                +R
Sbjct: 229 NRKFERR 235


>UniRef50_P37556 Uncharacterized protein yabN n=95 Tax=Bacillaceae RepID=YABN_BACSU
          Length = 489

 Score = 49.1 bits (116), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               + + Q + EE  E   A    D   +  E  D    ++ H  +   +    +  VI
Sbjct: 254 KQTHQSLKQYMIEECYELLEAIDEEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVI 313

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 314 KGISEKMVRRH 324


>UniRef50_B1C9L0 Putative uncharacterized protein n=1 Tax=Anaerofustis
           stercorihominis DSM 17244 RepID=B1C9L0_9FIRM
          Length = 449

 Score = 48.7 bits (115), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A   ++  +L  E  DL+     H  + +++   D   VI
Sbjct: 218 KQTHDSLKKHLLEETYELIDAIDRNNTEDLKEELGDLLLQIALHCQIEIENDSFDERDVI 277

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 278 DSISSKIIRRH 288


>UniRef50_B0TBB1 Mazg family protein n=4 Tax=Bacteria RepID=B0TBB1_HELMI
          Length = 546

 Score = 48.7 bits (115), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A  + D  +L  E  D++    +H L+   +    ++ ++
Sbjct: 295 EQSHQSLKPYLLEEAYEVLEAIDLGDDGKLKEELGDVLLQVVFHGLIAEGEGRFRISEIV 354

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 355 ETITEKMVRRH 365


>UniRef50_D2PPA8 MazG family protein n=2 Tax=Actinomycetales RepID=D2PPA8_9ACTO
          Length = 346

 Score = 48.7 bits (115), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 18/81 (22%), Positives = 28/81 (34%), Gaps = 18/81 (22%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTT-- 193
                 +A+ + EE  ET  A    DR  L  E  DL+    +H  +  +    D     
Sbjct: 138 EQTHASLAKYLLEETYETLEAIDSGDREHLREELGDLLLQVVFHARIAEEAPAEDEDDES 197

Query: 194 ------------VIENLRKRH 202
                       ++E L +RH
Sbjct: 198 DGPWSIDDVAAGIVEKLIRRH 218


>UniRef50_B8KRH4 MazG family protein n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KRH4_9GAMM
          Length = 275

 Score = 48.3 bits (114), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                K I     EE  E   A    D   +  E  DL+    ++  +  +    D  +V
Sbjct: 32  LKQNFKSITASTLEESYELVDAIEREDMPHVAEELGDLLFQVIFYSQLGKEAGDFDFDSV 91

Query: 195 ----IENLRKRH 202
               +E L +RH
Sbjct: 92  THTLVEKLIRRH 103


>UniRef50_B4RXM6 MazG protein n=3 Tax=Proteobacteria RepID=B4RXM6_ALTMD
          Length = 321

 Score = 48.3 bits (114), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + +   EE  E A A    D  ++ +E  DL+    ++  +  +        V 
Sbjct: 34  KQTMESLTRYTIEEAYEVADAIASGDMHDIKDELGDLLFQVVFYAQIASESSAFSFDDVA 93

Query: 196 E----NLRKRH 202
           +     L +RH
Sbjct: 94  QSISDKLVRRH 104


>UniRef50_B1XI42 MazG family protein n=22 Tax=Cyanobacteria RepID=B1XI42_SYNP2
          Length = 278

 Score = 48.3 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 20/74 (27%), Positives = 27/74 (36%), Gaps = 12/74 (16%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLT 192
                + +   V EE  E   A    D+  +  E  DL+  L V+LQ Q         L 
Sbjct: 35  LEQTPQTLIPYVIEEAYEVVHALRQDDQQAIAEELGDLL--LQVVLQAQIAQEYGHFSLQ 92

Query: 193 TVI----ENLRKRH 202
            V     E L +RH
Sbjct: 93  EVAEGISEKLIRRH 106


>UniRef50_D1PLC7 MazG protein n=3 Tax=Ruminococcaceae RepID=D1PLC7_9FIRM
          Length = 225

 Score = 48.3 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 14/68 (20%), Positives = 22/68 (32%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTT----V 194
            + I     EE  E   A  + D   L  E  D++    +H  +  +            V
Sbjct: 38  HQSIRMNFLEEAYEAVDAIDLEDSHLLCEELGDVLMQVAFHAQIEQEAGHFTWQQVCDGV 97

Query: 195 IENLRKRH 202
              L +RH
Sbjct: 98  CRKLIQRH 105


>UniRef50_C0WDQ0 Putative uncharacterized protein n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WDQ0_9FIRM
          Length = 264

 Score = 47.9 bits (113), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   K + +++ EE  E   A    D   +  E  D++    +H  +  +     +  VI
Sbjct: 33  AQDHKSMRRELVEEVYELLEAIDDGDVKGIREELGDVLFQVVFHARLAEEVGAFTMQDVI 92

Query: 196 ----ENLRKRH 202
                 L  RH
Sbjct: 93  TDVSRKLIHRH 103



 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 14/48 (29%), Positives = 22/48 (45%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI 195
           +KV EE  E   A    ++  +  E  DL + L V  +  GL+  T +
Sbjct: 172 EKVKEEENELKEAILSKNKDHVEEELGDLFFALSVYARKLGLEPETAL 219


>UniRef50_C1F8P3 MazG family protein n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F8P3_ACIC5
          Length = 284

 Score = 47.9 bits (113), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
                 I +   EE  E   A    +  EL +E  DL    +++  +  +    D+  V+
Sbjct: 32  EQDFHSIRKYTLEEVYEVFDAIETGNWDELRSELGDLLLQVLFYAQMAAEPGYFDVADVV 91

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 92  ETLNLKLIRRH 102



 Score = 40.6 bits (94), Expect = 0.029,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 25/65 (38%), Gaps = 5/65 (7%)

Query: 142 GTKRIAQKVGEEGVET-ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT----TVIE 196
             + +  KV EE  E  A  A    + ++  E  DL++ +  L +   +D          
Sbjct: 183 EVQGLLAKVREETAEVEAELAQSEGQRKIEEEIGDLLFTVANLARHLKVDPELALRDANA 242

Query: 197 NLRKR 201
             R+R
Sbjct: 243 KFRRR 247


>UniRef50_Q1IPL4 MazG family protein n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IPL4_ACIBL
          Length = 405

 Score = 47.9 bits (113), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
                 I     EE  E   A    D  EL  E  DL    +++  +  ++    +  V+
Sbjct: 136 EQTFDTIKPFTLEETYEVIEAIDNRDWDELPGELGDLLLQILFYAQMAAEEGKFTIDEVV 195

Query: 196 E----NLRKRH 202
           E     L  RH
Sbjct: 196 ETLSNKLVNRH 206


>UniRef50_B8D010 MazG family protein n=3 Tax=Bacteria RepID=B8D010_HALOH
          Length = 265

 Score = 47.6 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D   L  E  DL+    +   +  +    +L  VI
Sbjct: 31  KQDYYTLKPYIIEEAYEVVEALQKDDLELLKEELGDLLLQVVFESQIGKEKGDFNLIDVI 90

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 91  KIISEKLIRRH 101



 Score = 41.4 bits (96), Expect = 0.021,   Method: Composition-based stats.
 Identities = 9/52 (17%), Positives = 22/52 (42%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
                + +K+ EE  E       ++  E+  E  DL++ ++ L +   ++  
Sbjct: 167 DNISDVVRKIEEELAEVKEVIKTNEHKEIEEELGDLIFAVVNLCRFYRINPE 218


>UniRef50_C9LLX3 MazG protein n=1 Tax=Dialister invisus DSM 15470 RepID=C9LLX3_9FIRM
          Length = 362

 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           +     +     +E  E   A   +D   L  E  D++    +H  +  ++    +  V+
Sbjct: 136 SQNHMTLRTYFLQEVYEVIDAIEENDILNLKEELGDVLLQVVFHARIAEENGEFSMQDVV 195

Query: 196 E----NLRKRH 202
           +     + KRH
Sbjct: 196 DGIANKMVKRH 206


>UniRef50_A4EC03 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens
           ATCC 25986 RepID=A4EC03_9ACTN
          Length = 286

 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 21/71 (29%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I + + EE  E        D   L  E  D++     H  +        L  V 
Sbjct: 47  EQTHRSIGKNMIEEAYEALDCIEADDATHLREELGDVLMQVVLHAQIAADAGEFSLADVA 106

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 107 RDIDAKLIRRH 117


>UniRef50_C0QWZ2 Nucleoside triphosphate pyrophosphohydrolase n=2 Tax=Brachyspira
           RepID=C0QWZ2_BRAHW
          Length = 264

 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVI----ENLRKR 201
             EE  E   A    D   +  E  D++ H++    +   +   ++  V     E L +R
Sbjct: 35  FLEEAYEVVEAINNRDYENIKEELGDVLLHVVFFSELAKDENKFNIDDVCKNISEKLIRR 94

Query: 202 H 202
           H
Sbjct: 95  H 95


>UniRef50_C8W8X4 MazG family protein n=2 Tax=Coriobacteriaceae RepID=C8W8X4_ATOPD
          Length = 300

 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 17/123 (13%), Positives = 33/123 (26%), Gaps = 26/123 (21%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
                    T  ++  L +    L +      +            + I++ + EE  E  
Sbjct: 18  TKARPGAPQTHPEFDRLVRTIWRLRQEDGCPWDK-------EQTHQSISKNMIEEAYEAV 70

Query: 159 LAATVHDRFELTNEASDLMY----HLLVLL-----------QDQGLDLTTVIE----NLR 199
            A        L  E  D++     H  +             +  G ++  V       L 
Sbjct: 71  EAIAEGSPEHLEEELGDVLEQVVLHSQIEADGGVDSAGEGDRAAGFNIDDVCRALNQKLV 130

Query: 200 KRH 202
           +RH
Sbjct: 131 RRH 133


>UniRef50_A7VWY5 Putative uncharacterized protein n=4 Tax=Clostridiales
           RepID=A7VWY5_9CLOT
          Length = 275

 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I Q   EE  E   A    D   L  E  D++    +H L+  +    D + V 
Sbjct: 32  EQTHESIRQNFIEETYEAIEAIDTKDTELLKEELGDVLMQVVFHALMEEEAGKFDFSDVA 91

Query: 196 E----NLRKRH 202
           +     L  RH
Sbjct: 92  DGVCHKLIIRH 102


>UniRef50_Q0B0R5 MazG protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str.
           Goettingen RepID=Q0B0R5_SYNWW
          Length = 255

 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL---- 191
               + + + + EE  E   A  + D  +L  E  DL+    +H  +  ++   D     
Sbjct: 29  EQTHESLQRYLIEESYEVIEAIKMQDMHKLREELGDLLLQVVFHAALAEREGHFDFAGVA 88

Query: 192 TTVIENLRKRH 202
            TV + +  RH
Sbjct: 89  DTVKKKMIARH 99



 Score = 43.3 bits (101), Expect = 0.004,   Method: Composition-based stats.
 Identities = 11/55 (20%), Positives = 23/55 (41%), Gaps = 3/55 (5%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           G +   +K  EE  E   A       E+  E  D+ + L+ + + + +D    ++
Sbjct: 160 GVEGALEKFKEEVEELVAATK---PEEIKEEMGDVFFALVNVARLKNIDPEEALQ 211


>UniRef50_Q8NRS5 Predicted pyrophosphatase n=4 Tax=Corynebacterium
           RepID=Q8NRS5_CORGL
          Length = 195

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 11/68 (16%), Positives = 24/68 (35%), Gaps = 4/68 (5%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D   + +E  D    +++H  +  +    D+  V 
Sbjct: 89  TQTHESLIPYLEEESQEFIEAIHGGDDEHMKSELGDVLLQVLFHAEIAARQGRFDIFDVA 148

Query: 196 ENLRKRHQ 203
            +   + Q
Sbjct: 149 ASFVAKMQ 156


>UniRef50_D0L751 MazG nucleotide pyrophosphohydrolase n=1 Tax=Gordonia bronchialis
           DSM 43247 RepID=D0L751_GORB4
          Length = 322

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 24/65 (36%), Gaps = 6/65 (9%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQG--LDLTTVIE 196
              + + + EE  E   A    D  EL  E  DL    ++H  +   D     D+  V  
Sbjct: 115 HASLRRYLLEEVYELLDAIDHDDPAELCEELGDLLLQVLFHARIAADDPDAPFDIDDVAR 174

Query: 197 NLRKR 201
           +  ++
Sbjct: 175 SFTRK 179


>UniRef50_Q2LVG8 MazG-like domain protein n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVG8_SYNAS
          Length = 273

 Score = 47.2 bits (111), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ------DQGLD--L 191
               + I + + +E  E   A       +L  E  DL++ +L L Q      + G+   L
Sbjct: 38  QQKKEDIGRYLLDESYEVLDAVASGGSEDLKEELGDLLFQILFLAQIAEESGEFGIADVL 97

Query: 192 TTVIENLRKRH 202
             V   + +RH
Sbjct: 98  EEVTAKMIRRH 108



 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 14/51 (27%), Positives = 23/51 (45%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  K+ EE  E   A    DR  +T E  DL + L+ L +   +D    ++
Sbjct: 178 VIAKIEEELDELKAAIRTGDREHITEETGDLFFSLVNLCRFFSMDAEQTLQ 228


>UniRef50_A0QBX2 Transcriptional regulator, MazG family protein n=22
           Tax=Mycobacterium RepID=A0QBX2_MYCA1
          Length = 334

 Score = 46.8 bits (110), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 16/108 (14%), Positives = 35/108 (32%), Gaps = 12/108 (11%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G        A +   L     ++ + ++A P  S          + + + + EE  E   
Sbjct: 75  GARLISAPDAPRGERLVDAVAMMDKLRTAGPWES------EQTHESLRRFLLEETYELLD 128

Query: 160 AATVHDRFELTNEASD----LMYHLLVL--LQDQGLDLTTVIENLRKR 201
           A    +   L +E  D    +++H  +          +  V   L ++
Sbjct: 129 AVAGGNAEALRDELGDVLLQVLFHARIAEDAPQSAFTIDDVAAALIRK 176


>UniRef50_B0VJQ1 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VJQ1_9BACT
          Length = 255

 Score = 46.8 bits (110), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 19/72 (26%), Positives = 30/72 (41%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL---QDQGL-DLTTV 194
                + +     EE  E   A    D   L  E  DLM H+++     ++QGL ++  V
Sbjct: 25  LKQTRESLVPNFIEELYEVVEAIENKDYDALKEELGDLMLHIVMQAQISKEQGLWNIDDV 84

Query: 195 IEN----LRKRH 202
           +E     L +RH
Sbjct: 85  LEEISSKLIRRH 96



 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 30/61 (49%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
              K I +K+ EE  E A A   +++  +  E  D+++ L+ + +   +D  + ++   +
Sbjct: 158 QDIKPILEKLDEERDELAEALNSNEQDAIKEELGDMIFTLVNMARKLHIDAESALKECIR 217

Query: 201 R 201
           +
Sbjct: 218 K 218


>UniRef50_B6GA15 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=B6GA15_9ACTN
          Length = 290

 Score = 46.8 bits (110), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 21/71 (29%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA+ + EE  E        D   L  E  D++     H  +        +  + 
Sbjct: 50  KQTHASIAKNMIEEAYEAVDCIEADDAAHLREELGDVLMQVVLHAQIAADAGAFTMADIA 109

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 110 RDINEKLVRRH 120


>UniRef50_C7QJ07 MazG family protein n=7 Tax=Actinomycetales RepID=C7QJ07_CATAD
          Length = 358

 Score = 46.8 bits (110), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 14/80 (17%), Positives = 26/80 (32%), Gaps = 17/80 (21%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHD-------RFELTNEASDLM----YHLLVLLQDQG 188
                 + + + EE  ET       D       R  L  E  D++    +H  +  + + 
Sbjct: 161 EQTHASLVKYLLEEAYETVETIEDGDPLTPGPGRDALREELGDVLLQVMFHSRIAEEHEA 220

Query: 189 --LDLTTV----IENLRKRH 202
               +  V    +  L +RH
Sbjct: 221 DPFSVDDVADGIVAKLIRRH 240


>UniRef50_Q6AK03 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AK03_DESPS
          Length = 145

 Score = 46.8 bits (110), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 13/67 (19%), Positives = 26/67 (38%), Gaps = 8/67 (11%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL----LQDQGLDLTTVIEN-- 197
           + I + +  E  E   A    D   +  E  D++Y ++++     ++    L  V     
Sbjct: 34  ESIIKYLKSESQELIDALEKKDYPNICEELGDVLYIVILISSINKKEGQFSLEDVFREVN 93

Query: 198 --LRKRH 202
             L +RH
Sbjct: 94  AKLVRRH 100


>UniRef50_B2GM14 Putative uncharacterized protein n=1 Tax=Kocuria rhizophila DC2201
           RepID=B2GM14_KOCRD
          Length = 364

 Score = 46.4 bits (109), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 17/79 (21%), Positives = 30/79 (37%), Gaps = 16/79 (20%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHD-----RFELTNEASDLM----YHLLVLLQD---Q 187
               + + + + EE  E   A    +     R EL  E  D++    +H  +  +    Q
Sbjct: 74  EQTHESLLRYLVEESYEVVEAVEALEPSQRRRDELVEELGDVLLQVVFHARIGQEHPQPQ 133

Query: 188 GLDLTTVIE----NLRKRH 202
             D+T V+      L +RH
Sbjct: 134 RFDVTDVLAAVTDKLVRRH 152


>UniRef50_C7R009 MazG family protein n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R009_JONDD
          Length = 241

 Score = 46.4 bits (109), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 12/72 (16%), Positives = 24/72 (33%), Gaps = 8/72 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQG--LDLTT 193
                 + + + EE  E   A    D   +  E  D    +++H  +  +       +  
Sbjct: 51  EQTHTSLVRYLLEETYELVDAIESGDHTHMREELGDVLLQVLFHARIAEEHPDTPFTIDD 110

Query: 194 VIENLRK--RHQ 203
           V  +L    RH+
Sbjct: 111 VAHDLAAKLRHR 122


>UniRef50_Q30YJ6 MazG family protein n=6 Tax=Desulfovibrionales RepID=Q30YJ6_DESDG
          Length = 268

 Score = 46.4 bits (109), Expect = 5e-04,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLT--- 192
               + +   V EE  E   A    +  ++  E  D+M+ +     +     G  L    
Sbjct: 31  EQTPESLCDYVLEEAFELVDAIRSGNAADVREELGDVMFLMAFIGRLYQDRAGFSLEDAV 90

Query: 193 -TVIENLRKRH 202
             V   + +RH
Sbjct: 91  ADVAAKMVRRH 101


>UniRef50_D1W9A9 MazG family protein n=5 Tax=Prevotella RepID=D1W9A9_9BACT
          Length = 294

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 16/67 (23%), Positives = 25/67 (37%), Gaps = 8/67 (11%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV----I 195
           + +     EE  E   A    D+  +  E  D+M H+L    +  +    DL  V     
Sbjct: 45  ESLRPNTIEEVYELCDALLNDDKKNICKELGDVMEHVLFYSILGEETHDFDLADVCNKQA 104

Query: 196 ENLRKRH 202
           + L  RH
Sbjct: 105 DKLMFRH 111


>UniRef50_D1N5T1 MazG family protein n=1 Tax=Victivallis vadensis ATCC BAA-548
           RepID=D1N5T1_9BACT
          Length = 277

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
               + +++ + EE  E   A    +  ++ +E  DL+    +  +V  +        V 
Sbjct: 32  EQTRETLSRSLAEEAAEVLDAIDRGNAPDICDELGDLLMNVIFQAVVAEERGEFTFQDVC 91

Query: 195 ---IENLRKRH 202
              I+ + +RH
Sbjct: 92  GGIIDKMIRRH 102


>UniRef50_A9KR53 MazG family protein n=1 Tax=Clostridium phytofermentans ISDg
           RepID=A9KR53_CLOPH
          Length = 237

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 12/75 (16%), Positives = 22/75 (29%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLMY----HLLVLLQDQGLDL 191
                 +   + EE  E            D   L  E  D++     H  +  +     +
Sbjct: 28  EQTHDSLKNCMIEEAYEVVDGINQFTKNGDYDNLREELGDVLLQVIMHSQIAKEAGRFTV 87

Query: 192 TTVIEN----LRKRH 202
             VI+     + +RH
Sbjct: 88  EDVIDEIAKKMVRRH 102


>UniRef50_D1YB63 MazG family protein n=2 Tax=Propionibacterium acnes
           RepID=D1YB63_PROAC
          Length = 212

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
           +   + +   + EE  E   A       +L  E  DL+    +H  +  Q    D+  V 
Sbjct: 31  SQTHRSLVTYLVEETGEVIDAIEAGTDDDLVEELGDLLLQVVFHSRIGEQGGRFDINEVV 90

Query: 195 ---IENLRKRH 202
              +  L  RH
Sbjct: 91  GGIVAKLVARH 101


>UniRef50_B1YGQ0 MazG family protein n=5 Tax=Bacillales RepID=B1YGQ0_EXIS2
          Length = 476

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + + EE  E   A  + D   +  E  D++     H  + L +   D+  VI
Sbjct: 251 EQTHESLKKHLIEESYELLEAIDLQDDNLMIEELGDVLLQVMLHAQIGLDEGYFDVRDVI 310

Query: 196 ----ENLRKRH 202
               + + +RH
Sbjct: 311 GSVSDKMIRRH 321


>UniRef50_C1XVA0 MazG family protein n=2 Tax=Deinococci RepID=C1XVA0_9DEIN
          Length = 188

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A T  D   L  E  D++    +H ++  +        V 
Sbjct: 15  EQTHLSLRPYMLEEAAEAVDAMTAGDMPHLAEELGDVLLQVAFHSVIAEEAGSFTYPQVE 74

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 75  RLIVDKLIRRH 85


>UniRef50_UPI0001C36472 MazG family protein n=1 Tax=Clostridium hathewayi DSM 13479
           RepID=UPI0001C36472
          Length = 162

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 24/61 (39%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    D   L  E  D+++    H  +  ++    +  V+    E + +R
Sbjct: 71  LKEESEEVLAAIDNQDMENLCEELGDVLFQVLIHSRIAEENGAFTVADVVNGICEKMVRR 130

Query: 202 H 202
           H
Sbjct: 131 H 131


>UniRef50_A1SF64 MazG nucleotide pyrophosphohydrolase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SF64_NOCSJ
          Length = 233

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 28/72 (38%), Gaps = 12/72 (16%)

Query: 143 TKRIAQKVGEEGVETALAATVHDR----FELTNEASDLM----YHLLVLLQDQGLDLTTV 194
            + +A+ + EE  ET  A    DR      L  E  DL+    +H ++  +     L  V
Sbjct: 36  HRSLARFLLEETHETLEAIDDGDRTGDWSHLREELGDLLLQVYFHAVIAEETGEFTLDDV 95

Query: 195 IE----NLRKRH 202
                  + +R+
Sbjct: 96  ARDITAKMHRRN 107


>UniRef50_B1GYU5 Putative nucleotide pyrophosphohydrolase MazG n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GYU5_UNCTG
          Length = 132

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + +  E  E   A    D   L  E  D++    +H  +  + +  ++  VI
Sbjct: 29  KQTHESLVKHLFSEAEEVKKAVKNGDMDNLEEELGDILLQVVFHAQIAKESKSFNIAGVI 88

Query: 196 ENLR----KRH 202
           E L     +RH
Sbjct: 89  EKLNKKLVRRH 99


>UniRef50_P0AEY4 Protein mazG n=179 Tax=Proteobacteria RepID=MAZG_ECO57
          Length = 263

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA    EE  E   A    D  +L  E  DL+    ++  +  ++   D   + 
Sbjct: 26  EQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDIC 85

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 86  AAISDKLERRH 96


>UniRef50_P44723 Protein mazG homolog n=57 Tax=Gammaproteobacteria RepID=MAZG_HAEIN
          Length = 263

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 13/72 (18%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +   + EE  E   A    D   L  E  DL+    +   +  +D+      V
Sbjct: 26  LKQNYESMISCLTEETYEVIEAIEKKDIPNLREELGDLLLQVVFFSQLAREDKYFAFDDV 85

Query: 195 IE----NLRKRH 202
           ++     + +RH
Sbjct: 86  LQDVAEKIVRRH 97


>UniRef50_C8WQS0 MazG family protein n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WQS0_ALIAD
          Length = 493

 Score = 46.0 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNE----ASDLMYHLLVLLQDQGLDLTTV- 194
                 + + V EE  E A A    D   L  E       ++ H  +  +     L  V 
Sbjct: 254 KQTHASLRKYVVEEAYEVAEAIDEGDADHLAEELGDLLLQILLHARIAEEAGEFTLRDVF 313

Query: 195 ---IENLRKRH 202
                 L +RH
Sbjct: 314 AGLAAKLVRRH 324


>UniRef50_B1J1L8 MazG family protein n=14 Tax=Bacteria RepID=B1J1L8_PSEPW
          Length = 277

 Score = 46.0 bits (108), Expect = 8e-04,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  I     EE  E A      D   L  E  DL+    Y+  +  ++   +   V
Sbjct: 26  LKQNYASIVAHTIEEAYEVADTIERGDFEHLQGELGDLLFQVVYYSQLAREEGRFEFDGV 85

Query: 195 I----ENLRKRH 202
           +      L +RH
Sbjct: 86  VDAITRKLIRRH 97



 Score = 46.0 bits (108), Expect = 8e-04,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 23/62 (37%), Gaps = 4/62 (6%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRKR 201
           +  KV EE  E   A    D   L +E  DL++  + L +    D    +        +R
Sbjct: 177 VLDKVREELDEVLQAMADGDAEALEDEVGDLLFAAVNLARHLKQDPENALRRANRKFERR 236

Query: 202 HQ 203
            +
Sbjct: 237 FR 238


>UniRef50_B5YFB4 MazG n=2 Tax=Dictyoglomus RepID=B5YFB4_DICT6
          Length = 258

 Score = 46.0 bits (108), Expect = 8e-04,   Method: Composition-based stats.
 Identities = 12/64 (18%), Positives = 28/64 (43%), Gaps = 4/64 (6%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL---VLLQDQG-LDLTTVI 195
               + +     EE  E   A   +D+  +  E  D++ H+L   ++ +++   +   V 
Sbjct: 30  KQTPQTLIPYFLEEAYELIDALEKNDQEMIKEELGDILLHVLMQSIMAEEKNRFNFEEVC 89

Query: 196 ENLR 199
           +NL+
Sbjct: 90  KNLK 93



 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 29/61 (47%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
             +K I  K+ EE  E   A    ++ ++  E  DL++ ++ + +  G+D  + +    K
Sbjct: 161 KNSKEIIPKLYEELKELEKAIQEDNKEDMEEEIGDLLFTIVNIARHLGIDPESSLRKTNK 220

Query: 201 R 201
           +
Sbjct: 221 K 221


>UniRef50_B0MPG5 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM
           15702 RepID=B0MPG5_9FIRM
          Length = 288

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL---- 191
               K +   V EE  E   A    D   L  E  DL+    +H  +  +    +     
Sbjct: 59  EQDHKSVRMNVLEEAYEVMEAIDADDAAMLKEELGDLLFQAVFHCEIEKERGRFEFNDIC 118

Query: 192 TTVIENLRKRH 202
             V + +  RH
Sbjct: 119 DDVTKKMIYRH 129


>UniRef50_A8UAP0 Putative uncharacterized protein n=1 Tax=Carnobacterium sp. AT7
           RepID=A8UAP0_9LACT
          Length = 351

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/71 (25%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D   +  E  DL    +YH     Q        VI
Sbjct: 250 EQTHQTLLAYLDEEVREFKTAVENDDSDNMVEELGDLLMQVLYHTNFGEQSGYFSFEEVI 309

Query: 196 E----NLRKRH 202
           E     LR+RH
Sbjct: 310 ETLNKKLRRRH 320


>UniRef50_C0AEE9 MazG family protein (Fragment) n=1 Tax=Opitutaceae bacterium TAV2
           RepID=C0AEE9_9BACT
          Length = 234

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/72 (16%), Positives = 24/72 (33%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  + + + +E  E       +D   +  E  D++    +H  +  +    DL  V
Sbjct: 57  IEQTHATLVRCLIDEVSELIDTIDRNDLPHMREELGDVLIQVIFHAQIASETGAFDLDDV 116

Query: 195 IEN----LRKRH 202
                  L +RH
Sbjct: 117 AREVNDKLIRRH 128


>UniRef50_A6G509 MazG family protein n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G509_9DELT
          Length = 304

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   + +     EE  E   A    D  E   E  DL+    +H  +  ++   DL  V+
Sbjct: 51  AQTLESLRPYAVEEAHEVLEAIDGGDPEEHRRELGDLLFQIVFHAALREREGAFDLDGVV 110

Query: 196 E----NLRKRH 202
           E     + +RH
Sbjct: 111 EAIRSKMIRRH 121



 Score = 39.9 bits (92), Expect = 0.048,   Method: Composition-based stats.
 Identities = 13/64 (20%), Positives = 24/64 (37%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----N 197
                  K  EE  E   A    D+  +  E  DL++ L+ + Q  G++  + +      
Sbjct: 206 DLDGPRDKAREEWAELEEAIASGDQQAIAEEFGDLLFVLVRMGQKLGVEAESALRATNLK 265

Query: 198 LRKR 201
             +R
Sbjct: 266 FERR 269


>UniRef50_D1A7M2 MazG family protein n=8 Tax=Actinomycetales RepID=D1A7M2_THECD
          Length = 329

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 14/74 (18%), Positives = 22/74 (29%), Gaps = 11/74 (14%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG---LDLT 192
                 +   + EE  E A      D   L  E  D++    +H  V  +        + 
Sbjct: 136 KQTHATLVPYLLEEAYELADTVEDGDYAALREELGDVLMQVVFHARVAEERTDDTRFTID 195

Query: 193 TVIE----NLRKRH 202
            V       L +RH
Sbjct: 196 DVAAGIVDKLVRRH 209


>UniRef50_D0LI16 MazG family protein n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LI16_HALO1
          Length = 289

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 15/57 (26%), Positives = 24/57 (42%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             T   + KV EE  E   AA   D+  +  E  DL++ ++ L +  G D    +  
Sbjct: 189 EDTAGCSAKVREELGEVEHAAASGDQAAVEAEIGDLLFAVVSLARKHGCDPEHALRQ 245



 Score = 45.3 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 11/71 (15%), Positives = 21/71 (29%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A       +   E  DL+    +   +   +    +  V+
Sbjct: 50  EQTLSTLIPYLIEESYEVIDAIETGTPADHCEELGDLLLQIVFQAALREAEGQFGIDDVV 109

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 110 RGIADKLVRRH 120


>UniRef50_Q1J066 MazG family protein n=5 Tax=Deinococci RepID=Q1J066_DEIGD
          Length = 210

 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 23/71 (32%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A        L  E  D++    +H ++  ++       V 
Sbjct: 22  KQTHESLRPYLLEEAAEAVDAV-SEGPAALAGELGDVLLQVAFHAVIAEEEGTFTYADVE 80

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 81  RGIVEKLIRRH 91


>UniRef50_Q1NJI5 MazG nucleotide pyrophosphohydrolase n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NJI5_9DELT
          Length = 130

 Score = 45.3 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 24/62 (38%), Gaps = 8/62 (12%)

Query: 149 KVGEEGVETALAATVHDRFELTNEASDLMYHLLVL----LQDQGLDLTTVI----ENLRK 200
            + EE  E   A    +   +  E  DL++ ++ L     + Q   L  VI      + +
Sbjct: 40  YLLEEAHELMEALEGDNPEHIREELGDLLFQIIFLSQLYSERQEFTLAEVIDGIRAKMIR 99

Query: 201 RH 202
           RH
Sbjct: 100 RH 101


>UniRef50_C5VBE9 Nucleoside triphosphate pyrophosphohydrolase n=2
           Tax=Corynebacterium matruchotii RepID=C5VBE9_9CORY
          Length = 226

 Score = 45.3 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVH-DRFELTNEASD----LMYHLLVLLQDQGLDLTTV 194
               + +   + EE  E A A T   D  EL  E  D    +++H  +  +    D   V
Sbjct: 120 EQTHETLLPYLREETTELAEAITTRADDAELMAELGDVLLQVLFHAEIAARRGAFDFGDV 179

Query: 195 ----IENLRKR 201
               I  +R+R
Sbjct: 180 VGSFIGKMRRR 190


>UniRef50_C7RAH4 MazG family protein n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAH4_KANKD
          Length = 266

 Score = 44.9 bits (105), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/62 (19%), Positives = 26/62 (41%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               + +KV EE  E   A   +D+  +  E  DL++  + L +   +D    +    ++
Sbjct: 172 EVSGVIEKVEEEIAELKQAIANNDQQNIEEEIGDLLFSCVNLSRHLKVDAEAALRKSSRK 231

Query: 202 HQ 203
            +
Sbjct: 232 FE 233



 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 24/67 (35%), Gaps = 8/67 (11%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL----TTVI 195
           + I     EE  E A A    D  EL  E  DL+    ++  +  ++   D       V 
Sbjct: 39  ETIVPYTLEEAYEVADAIERGDFEELHGELGDLLFQVIFYAQIGQEEGRFDFESIAEKVS 98

Query: 196 ENLRKRH 202
             L  RH
Sbjct: 99  NKLVSRH 105


>UniRef50_Q6MDA8 Putative uncharacterized protein n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MDA8_PARUW
          Length = 217

 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 30/71 (42%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL--LQDQG--LDLTTVI 195
               + +   V EE  E   A  + +  ++  E  DL ++++ L  L ++     L  ++
Sbjct: 25  EQTLQSMRSSVIEEVYELVEAIDLENNEKIKEELGDLCFNVIFLGKLAERDKKFSLHDML 84

Query: 196 EN----LRKRH 202
           +     L +RH
Sbjct: 85  KEINEKLIRRH 95


>UniRef50_A2BTR6 MazG family protein n=7 Tax=Prochlorococcus marinus
           RepID=A2BTR6_PROMS
          Length = 284

 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 16/67 (23%), Positives = 27/67 (40%), Gaps = 8/67 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL------QDQGLDLTTV 194
                +   + EE  E   A    +   +  E  DL+  L V+L      +++   L  V
Sbjct: 44  QSHISLIPFLYEESNEFIDAIYEKNAVNICEELGDLL--LQVMLHSEIGYEEKEFTLNDV 101

Query: 195 IENLRKR 201
           I+NL K+
Sbjct: 102 IKNLNKK 108



 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 25/57 (43%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             T  I +K+ EE  E   A    +  E+ NE  D+ + LL L     ++  + ++ 
Sbjct: 181 GSTDEIFKKLEEEINELKEAIKSKNDSEIKNEFGDIYFTLLNLSNFLKINPESALQK 237


>UniRef50_UPI0001C317DB MazG family protein n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C317DB
          Length = 275

 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 21/71 (29%), Positives = 33/71 (46%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY---HLLVLLQDQGL-DLTTVI 195
               + I     EE  E A AA   D  +L +E  D+++    L +LL+++G  DL  V 
Sbjct: 31  EQDERTIVPHTLEEAYELADAANRRDDVKLLDELGDVLFQVHFLALLLEERGAGDLAAVA 90

Query: 196 ----ENLRKRH 202
               + L +RH
Sbjct: 91  ENTRQKLIRRH 101


>UniRef50_C8WJX9 MazG family protein n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WJX9_EGGLE
          Length = 323

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 19/73 (26%), Positives = 27/73 (36%), Gaps = 12/73 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLTT 193
               + IA  + EE  E   A    D   L  E  D++  L V+LQ Q        D+  
Sbjct: 54  TQTHQSIAHNMIEEAYEAVDAIEAADVAHLREELGDVL--LQVVLQSQIASDAGEFDIND 111

Query: 194 VIE----NLRKRH 202
           V       + +RH
Sbjct: 112 VCADVNEKMVRRH 124


>UniRef50_C1A8D0 Putative nucleoside triphosphate pyrophosphohydrolase n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1A8D0_GEMAT
          Length = 270

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 15/68 (22%), Positives = 24/68 (35%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTV---- 194
              +   + EE  E   A    D   L +E  DL    ++H +V  +     +  V    
Sbjct: 43  HASLRPYLIEEAHEVDDAIAQGDDAVLRDELGDLFLQVLFHSVVAEERGAFGMQDVAGAL 102

Query: 195 IENLRKRH 202
           I  +  RH
Sbjct: 103 IAKMHARH 110


>UniRef50_A4A3U0 MazG nucleotide pyrophosphohydrolase family protein n=3
           Tax=Bacteria RepID=A4A3U0_9GAMM
          Length = 282

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 15/66 (22%), Positives = 26/66 (39%), Gaps = 4/66 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----N 197
           G   + +KV EE  E   A    D      E  DL++ ++ L +   +D  T +      
Sbjct: 185 GVNPVLEKVDEELRELREAMAQGDPKATEEELGDLLFTVVNLSRHLKIDAETALRHASGK 244

Query: 198 LRKRHQ 203
             +R +
Sbjct: 245 FERRFR 250


>UniRef50_A3WPS6 Predicted pyrophosphatase MazG n=2 Tax=Idiomarina
           RepID=A3WPS6_9GAMM
          Length = 259

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 13/72 (18%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +     EE  E   A    DR  + +E  DL+    ++  +  ++   D   +
Sbjct: 27  LKQTFESLLPYTIEETYEVVDAINGGDRAAMKDELGDLLFQVVFYAQLGEEEGSFDFEAI 86

Query: 195 IE----NLRKRH 202
            +     L +RH
Sbjct: 87  AQHTADKLIRRH 98



 Score = 39.9 bits (92), Expect = 0.054,   Method: Composition-based stats.
 Identities = 12/51 (23%), Positives = 23/51 (45%), Gaps = 3/51 (5%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           I  KV EE  E   A    +   L  E  DL++ ++ L + + ++    ++
Sbjct: 168 IYAKVYEEIDEVRTA---ENDDHLEEEIGDLLFAVINLARHKQVNPERALQ 215


>UniRef50_D2S938 MazG family protein n=1 Tax=Geodermatophilus obscurus DSM 43160
           RepID=D2S938_9ACTO
          Length = 309

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 13/74 (17%), Positives = 25/74 (33%), Gaps = 11/74 (14%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQD---QGLDLT 192
                 +   + EE  E   A    D   +  E  D++    +H  V  +    +   + 
Sbjct: 114 EQTHASLRGYLLEEAHEAYDAIVDDDAAGMREELGDVLLQVVFHARVAAEADPSRRFTVD 173

Query: 193 TV----IENLRKRH 202
            V    ++ L +RH
Sbjct: 174 DVAGDLVDKLVRRH 187


>UniRef50_UPI000197392B MazG family protein n=1 Tax=Clostridium sp. M62/1
           RepID=UPI000197392B
          Length = 152

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 21/61 (34%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           V EE  E   A    D   L  E  DL+    ++  +  +        V+      + +R
Sbjct: 53  VTEEAKEVVQAVKQQDMDNLCEELGDLLFQVVFYSQMAQEQGLFTFEQVVDGISAKMVRR 112

Query: 202 H 202
           H
Sbjct: 113 H 113


>UniRef50_Q6I858 Predicted MazG-family transcriptional regulator n=1
           Tax=Aeromicrobium erythreum RepID=Q6I858_9ACTO
          Length = 199

 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 28/72 (38%), Gaps = 9/72 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLL-QDQGLDLTTV 194
               + +++ + EE  ET  A    D   L  E  DL+    +H  V     +G D+  V
Sbjct: 29  QQTHESLSRYLLEETYETLEALDDGDTDLLREELGDLLMQVVFHAAVAADTGEGWDVDDV 88

Query: 195 IE----NLRKRH 202
                  L +R+
Sbjct: 89  AAGITDKLVRRN 100


>UniRef50_P33653 Uncharacterized 26.1 kDa protein in blaB 3'region n=3
           Tax=Actinomycetales RepID=YBL1_STRCI
          Length = 242

 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 21/62 (33%), Gaps = 6/62 (9%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTTVIE 196
              + +   EE  E   A    DR EL  E  D++    +H  +   D      +  V  
Sbjct: 65  HHDLVKYGVEEMYELVDAIEAGDRGELREELGDVLLQVVFHARIAQDDADEPFAIDDVAG 124

Query: 197 NL 198
            L
Sbjct: 125 TL 126


>UniRef50_C1YI03 MazG family protein n=1 Tax=Nocardiopsis dassonvillei subsp.
           dassonvillei DSM 43111 RepID=C1YI03_NOCDA
          Length = 265

 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 14/76 (18%), Positives = 26/76 (34%), Gaps = 13/76 (17%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL---- 191
                 +A+ + +E  ET       D   L  E  D++    +H  V  +    D     
Sbjct: 46  DQTHGSLAKYLIQEAYETLETIEEGDFALLREELGDVLLQVVFHAAVAAERPEGDPARFT 105

Query: 192 -----TTVIENLRKRH 202
                  +I+ + +RH
Sbjct: 106 VDDVADAIIDKMTRRH 121


>UniRef50_Q3JCR4 Tetrapyrrole methylase family protein / MazG family protein n=2
           Tax=Nitrosococcus oceani RepID=Q3JCR4_NITOC
          Length = 180

 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 14/63 (22%), Positives = 26/63 (41%), Gaps = 5/63 (7%)

Query: 146 IAQKVGEEGVETALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRK 200
           I +K+ EE  E   A T   +   L  E  DL++  + L +  G+     +    +   +
Sbjct: 82  ILEKIEEELQEVRAALTSNENSSRLQEEIGDLLFACINLARHTGIMPEAALDSCSDKFER 141

Query: 201 RHQ 203
           R +
Sbjct: 142 RFR 144


>UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL
          Length = 180

 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 12/51 (23%), Positives = 21/51 (41%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
           + EE  E +  A       L  E +D++Y         G+DL  V+  + +
Sbjct: 85  LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135


>UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TY54_METKA
          Length = 103

 Score = 43.7 bits (102), Expect = 0.003,   Method: Composition-based stats.
 Identities = 15/54 (27%), Positives = 25/54 (46%), Gaps = 2/54 (3%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           + EE +E   A    +R  L  E  DL+  +   L    +DL  ++E  R+R +
Sbjct: 43  LVEEAIEVRNAVRSGNREALIEELGDLLIEVEAFLTAHDIDLEEIVE--RQRTK 94


>UniRef50_Q5HIH0 Tetrapyrrole methylase family protein n=63 Tax=Staphylococcaceae
           RepID=Q5HIH0_STAAC
          Length = 397

 Score = 43.7 bits (102), Expect = 0.003,   Method: Composition-based stats.
 Identities = 13/68 (19%), Positives = 28/68 (41%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI--- 195
            + + + + EE  E   A    D + +  E  D    ++ H  +  ++  +D+  VI   
Sbjct: 260 HETLKRYLLEETFELFEAIDNEDDWHMIEELGDILLQVLLHTSIGKKEGYIDIKEVITSL 319

Query: 196 -ENLRKRH 202
              + +RH
Sbjct: 320 NAKMIRRH 327


>UniRef50_Q3B1B2 MazG n=12 Tax=Chlorobiaceae RepID=Q3B1B2_PELLD
          Length = 285

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 13/56 (23%), Positives = 22/56 (39%), Gaps = 4/56 (7%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTVIENLRKR 201
           + EE  E   A   +D  EL  E  DL  H+     +  +        V++ L ++
Sbjct: 55  LLEESYELVDAIDGNDDEELKKELGDLFLHVCFQAELGEESGKFTFNEVMDGLSRK 110


>UniRef50_D2NPA3 Predicted pyrophosphatase n=2 Tax=Rothia mucilaginosa
           RepID=D2NPA3_9MICC
          Length = 273

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 16/75 (21%), Positives = 27/75 (36%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFE---LTNEASDLM----YHLLVLLQD-QGLDL 191
                 + + + EE  E   A           L  E  D++    +H  +   + QG D+
Sbjct: 73  EQTHASLIRYLVEEAYEVVEAVETGGEPNMPLLREELGDVLLQVVFHSDIAAANPQGFDI 132

Query: 192 TTV----IENLRKRH 202
             V    ++ LR RH
Sbjct: 133 VQVVEGLVQKLRSRH 147


>UniRef50_Q2SL25 Predicted pyrophosphatase n=20 Tax=Proteobacteria
           RepID=Q2SL25_HAHCH
          Length = 288

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTT- 193
                  I     EE  E A A    D   L +E  DL+    ++  +  +         
Sbjct: 34  LKQDFASIVPFTIEETYEVADAIEREDWPHLRDELGDLLFQAVFYSQLAQEKDLFQWPDI 93

Query: 194 ---VIENLRKRH 202
              V+  L +RH
Sbjct: 94  VDGVVRKLLRRH 105


>UniRef50_A9AYB5 MazG family protein n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9AYB5_HERA2
          Length = 381

 Score = 43.3 bits (101), Expect = 0.004,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  ET  A    D   L  E  DL+    +H     Q    +L  V 
Sbjct: 148 KQTHASLREFLLEETHETLEALDAEDWPNLKEELGDLLLQIVFHAEFGRQAGRFNLDQVY 207

Query: 196 ----ENLRKRH 202
                 L +RH
Sbjct: 208 TAINSKLIRRH 218


>UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG family protein n=15
           Tax=Bacteria RepID=A4IJD4_GEOTN
          Length = 486

 Score = 43.3 bits (101), Expect = 0.004,   Method: Composition-based stats.
 Identities = 16/56 (28%), Positives = 27/56 (48%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +  + I QKV EE  E     +   R EL +E  D+M+ L+ L +  G+     ++
Sbjct: 387 NDVEPIWQKVEEEMAEFRAETSSGRRAELVSEFGDVMFALINLARYYGIQPEEALQ 442


>UniRef50_A0LK91 MazG family protein n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LK91_SYNFM
          Length = 229

 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL----QDQGLDLTTVI 195
                ++   + EE  E A A     R E   E  DL++ +  L+    +     L  V 
Sbjct: 33  KQTPDKVQTYLIEEAHEAASAVRAGRREEAAEELGDLLFMVFFLIHLYEESGDFRLEEVC 92

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 93  DAICEKMVRRH 103


>UniRef50_Q65VQ2 MazG protein n=1 Tax=Mannheimia succiniciproducens MBEL55E
           RepID=Q65VQ2_MANSM
          Length = 234

 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 22/61 (36%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    +  +L  E  DL+    +   +  ++       V+    E L  R
Sbjct: 5   LIEESYEVVEAIQQKNTADLREELGDLLMQVVFLSQLAAEENKFTFDDVVNDIAEKLIYR 64

Query: 202 H 202
           H
Sbjct: 65  H 65


>UniRef50_A3YTK8 MazG n=1 Tax=Synechococcus sp. WH 5701 RepID=A3YTK8_9SYNE
          Length = 313

 Score = 43.3 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 14/54 (25%), Positives = 24/54 (44%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +KV EE  E   A    D+     E  D+++ L+ + +  GLD    +    +R
Sbjct: 214 EKVHEELDELKQAVASGDKVHAQEELGDVLFTLVNVARWCGLDPEAGLAGTNRR 267


>UniRef50_B7H015 MazG family protein n=18 Tax=Acinetobacter RepID=B7H015_ACIB3
          Length = 268

 Score = 43.3 bits (101), Expect = 0.006,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + +   EE  E   A    D  E+ NE  DL+    +   +  +    +   V+
Sbjct: 20  EQTPMSLTKYAIEEAYEVEAAIRQGDINEIRNELGDLLLQVVFQSQMFSEQGAFNFQDVV 79

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 80  EAISEKLVRRH 90


>UniRef50_B7JWE8 MazG nucleotide pyrophosphohydrolase n=2 Tax=Cyanothece
           RepID=B7JWE8_CYAP8
          Length = 110

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 15/61 (24%), Positives = 24/61 (39%), Gaps = 4/61 (6%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + +  K+ EE  E   A    D   L  E  DL   +  +L    +   TVI   ++R 
Sbjct: 35  LEALKHKLLEEAQEVIEA----DPENLVKELGDLFEVIDNILIAYQISRETVINYQQQRR 90

Query: 203 Q 203
           +
Sbjct: 91  K 91


>UniRef50_A5CTB1 Putative pyrophosphatase n=4 Tax=Actinobacteria (class)
           RepID=A5CTB1_CLAM3
          Length = 254

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 14/69 (20%), Positives = 27/69 (39%), Gaps = 9/69 (13%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLL-QDQGLDLTTVIE- 196
            + +   + EE  E   A    D   +  E +D++    +H  +   + +G DL  V   
Sbjct: 47  HRTLVPYLLEESHELVEAIETDDVPGMREELADVLLQVVFHADIARTEGEGFDLADVART 106

Query: 197 ---NLRKRH 202
               + +RH
Sbjct: 107 ATEKMVRRH 115


>UniRef50_C6CRL2 MazG family protein n=6 Tax=Firmicutes RepID=C6CRL2_PAESJ
          Length = 492

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 16/68 (23%), Positives = 25/68 (36%), Gaps = 8/68 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ------GLDLTT 193
               + I +   EE  E   A    D   +  E  D++  L V+L  Q         +  
Sbjct: 257 EQTHQSIRKNFIEELYEALEAIDNDDPDNMREEFGDVI--LQVMLHSQMEEETGAFSVYD 314

Query: 194 VIENLRKR 201
           VIE L ++
Sbjct: 315 VIEGLNEK 322


>UniRef50_B1ZW78 MazG family protein n=1 Tax=Opitutus terrae PB90-1
           RepID=B1ZW78_OPITP
          Length = 225

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 10/61 (16%), Positives = 20/61 (32%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIEN----LRKR 201
           + +E  E        D   +  E  D++    +H  +  +    +   V       L +R
Sbjct: 35  LIDEVSELIDTIDRGDMPHMREELGDVLIQIVFHARMAEEAGHFNFEDVAREINEKLVRR 94

Query: 202 H 202
           H
Sbjct: 95  H 95


>UniRef50_C7JCN1 Nucleotide pyrophosphohydrolase MazG n=8 Tax=Acetobacter
           pasteurianus RepID=C7JCN1_ACEP3
          Length = 325

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + IA    EE  E   A    D     +E  DL+    Y   +  ++   D  TV 
Sbjct: 72  EQTHETIAPYAIEEAYEVLDAIQKKDWNAFPDELGDLLLQVVYQAQLAQEEGRFDFATVA 131

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 132 RMITEKMIRRH 142


>UniRef50_Q6MMY5 Tetrapyrrole methylase family protein/MazG family protein n=1
           Tax=Bdellovibrio bacteriovorus RepID=Q6MMY5_BDEBA
          Length = 294

 Score = 42.9 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 12/63 (19%), Positives = 24/63 (38%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
                +   V EE  E   A    +  E+ +E  D ++ L  L +   ++   V+    +
Sbjct: 193 EDMDGVLANVEEEYQELREALDEGNDSEIEHELGDALFSLAQLGRHVQMEPEQVLRKANQ 252

Query: 201 RHQ 203
           R +
Sbjct: 253 RFE 255



 Score = 41.8 bits (97), Expect = 0.015,   Method: Composition-based stats.
 Identities = 14/76 (18%), Positives = 24/76 (31%), Gaps = 13/76 (17%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFE-----LTNEASDLMY----HLLVLLQDQGLD 190
               + + Q   EE  E   A  +          +  E  D+++    H  +  +     
Sbjct: 54  EQTHESLTQYAIEETHELVEALELPASDASKDLKMKEELGDVLFQVVLHAQLAAERGAFT 113

Query: 191 LTTVIE----NLRKRH 202
           L  VI      L +RH
Sbjct: 114 LEDVIAGISEKLVRRH 129


>UniRef50_B5Y801 MazG family protein n=1 Tax=Coprothermobacter proteolyticus DSM
           5265 RepID=B5Y801_COPPD
          Length = 352

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 11/67 (16%), Positives = 27/67 (40%), Gaps = 4/67 (5%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----E 196
               ++  K+ EE  E   A        + +E  DL++ ++ L +   +D    +    +
Sbjct: 263 EDPMQLKDKLEEEFEELRCAFESGQTQSMKDEVGDLLFTVVNLARLLNVDPEDALLHSSK 322

Query: 197 NLRKRHQ 203
             ++R +
Sbjct: 323 KFQRRLK 329


>UniRef50_A8ATT3 Gp45 n=1 Tax=Listeria phage P35 RepID=A8ATT3_9CAUD
          Length = 104

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 16/61 (26%), Positives = 23/61 (37%)

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           S    L     +    KV EE  ET  A    D+  L  E  D+   +++L Q   L + 
Sbjct: 16  SRNKGLDTKDPRNQMLKVVEEVGETTQALVKGDKDHLPEEIGDIFVTIVILAQQLSLTIE 75

Query: 193 T 193
            
Sbjct: 76  Q 76


>UniRef50_B8FGV8 MazG family protein n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FGV8_DESAA
          Length = 266

 Score = 42.9 bits (100), Expect = 0.007,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL----LQDQGLDLTTVI 195
               + +   + EE  E   A    +      E  D+++H+  L     +        V 
Sbjct: 33  KQTPESMRVYLVEEMYELLDALESDEPSAALEELGDVLFHVFFLSCMFEERGEFTAMDVA 92

Query: 196 ----ENLRKRH 202
               E +  RH
Sbjct: 93  KANTEKMIARH 103


>UniRef50_D1R6W2 Putative uncharacterized protein n=1 Tax=Parachlamydia
           acanthamoebae str. Hall's coccus RepID=D1R6W2_9CHLA
          Length = 252

 Score = 42.6 bits (99), Expect = 0.009,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL---MYHLLVLLQDQGL-----DL 191
               + +   + EE  E   A    D   +  E  DL   ++ +  L + +G       +
Sbjct: 64  EQTLETLRSTLLEEAAEWIEAVDSGDVNHMEEELGDLFLNLFFITKLAEKEGKFRMAEPV 123

Query: 192 TTVIENLRKRH 202
             +I  L +RH
Sbjct: 124 EHIIAKLIRRH 134


>UniRef50_C3JX00 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Rhodococcus
           erythropolis SK121 RepID=C3JX00_RHOER
          Length = 316

 Score = 42.2 bits (98), Expect = 0.012,   Method: Composition-based stats.
 Identities = 12/48 (25%), Positives = 19/48 (39%), Gaps = 4/48 (8%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVL 183
           A   + ++  + EE  E   A    DR  L  E  DL    ++H  + 
Sbjct: 110 AQTHESLSNYLLEETYEVLDAILAGDREALNEELGDLLLQVLFHARIA 157


>UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax=Bacillales
           RepID=A7GLU0_BACCN
          Length = 108

 Score = 42.2 bits (98), Expect = 0.012,   Method: Composition-based stats.
 Identities = 14/68 (20%), Positives = 28/68 (41%), Gaps = 5/68 (7%)

Query: 132 TSYTAKLYASG--TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
            ++T ++       + + +K  EE  E   A     +     E +DL+  +  L Q +G+
Sbjct: 21  KTFTTRMLDEQEYIEEVCKKTQEELAEYVEA---ESKEHKVEELADLLELVNALAQHEGV 77

Query: 190 DLTTVIEN 197
            L  V + 
Sbjct: 78  TLEDVEKV 85


>UniRef50_A5ZV93 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC
           29174 RepID=A5ZV93_9FIRM
          Length = 133

 Score = 42.2 bits (98), Expect = 0.012,   Method: Composition-based stats.
 Identities = 10/69 (14%), Positives = 27/69 (39%), Gaps = 8/69 (11%)

Query: 143 TKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTV 194
            + + + + EE  E           +D   L  E  D+++    H ++  ++    +  V
Sbjct: 26  HESLKKYLLEESNEVLEGIDRLSKENDSTNLCEELGDVLFQVALHSVIAEEEGLFTVEDV 85

Query: 195 IENLRKRHQ 203
           I ++  + +
Sbjct: 86  IRDVSSKMK 94


>UniRef50_C0Q9D5 Tetrapyrrole methylase family protein (MazG family protein) n=1
           Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0Q9D5_DESAH
          Length = 273

 Score = 41.8 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 27/62 (43%), Gaps = 4/62 (6%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----NLRKR 201
           + +KV EE  E   A    D+ E+  E  D+++ L  + +  G+   T +        +R
Sbjct: 176 VIEKVEEEWKEFTQALATGDKDEIAMEFGDILFTLSNVARFAGIHPETALARSTEKFEQR 235

Query: 202 HQ 203
            +
Sbjct: 236 FR 237



 Score = 39.1 bits (90), Expect = 0.099,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL----QDQGLDLTTVI 195
               + + + + EE  E   A    D  ++ +E  D+++ L+ +     +    D+   I
Sbjct: 34  KQTPETMWKCLIEEVYELLEAIEKDDAADVCDELGDVLFQLVFIAELYRERGAFDIFDAI 93

Query: 196 ----ENLRKRH 202
               + + +RH
Sbjct: 94  SKSAQKMIRRH 104


>UniRef50_A6TJN3 MazG family protein n=33 Tax=Bacteria RepID=A6TJN3_ALKMQ
          Length = 486

 Score = 41.8 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 11/51 (21%), Positives = 23/51 (45%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
             +   +KV EE  E   A    +   +  E+ DL++ ++ +L+   +D  
Sbjct: 389 DVREAVEKVHEELQELLEAKAEGEVEHIQEESGDLLFAVVNVLRFFKVDPE 439


>UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HVH1_9BACT
          Length = 292

 Score = 41.8 bits (97), Expect = 0.016,   Method: Composition-based stats.
 Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 1/58 (1%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +  KV EE  E   AA       LT E  D+++ +    +  G+     +    K+ +
Sbjct: 194 VLDKVEEECAE-IRAALSEGSARLTEEIGDMLFAMAQFARLSGIRPEEALSEANKKFK 250


>UniRef50_Q027H8 MazG family protein n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q027H8_SOLUE
          Length = 263

 Score = 41.8 bits (97), Expect = 0.016,   Method: Composition-based stats.
 Identities = 12/56 (21%), Positives = 28/56 (50%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
              +++ +K+ EE  E A+A T     E+ +E  D+++ ++ L +   +D    + 
Sbjct: 166 ENPEQVLEKLHEELAEFAVARTNAQHDEIEDELGDMLFVMVNLARFVKVDPEQALR 221



 Score = 40.2 bits (93), Expect = 0.038,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 I     EE  E   A       EL  E  D M    ++  +  + +   +   +
Sbjct: 31  EQTFDTIKPYTLEETYEVLDAIDRRQWDELAEELGDFMLQAVFYAQMAAEQKLFRIDDAL 90

Query: 196 E----NLRKRH 202
           +     L +RH
Sbjct: 91  DAINEKLVRRH 101


>UniRef50_Q1QX16 MazG family protein n=12 Tax=Proteobacteria RepID=Q1QX16_CHRSD
          Length = 280

 Score = 41.4 bits (96), Expect = 0.017,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I     EE  E A A       EL  E  DL+    Y+     ++Q  D   V+
Sbjct: 32  KQDWQSIVPHTLEEAYEVADAIERRAFDELPGELGDLLFQVVYYSQFAREEQRFDFHDVV 91

Query: 196 ----ENLRKRH 202
                 +  RH
Sbjct: 92  DTVTAKMVARH 102


>UniRef50_C4B7S4 Putative MazG family protein n=1 Tax=Desulfotignum balticum
           RepID=C4B7S4_9DELT
          Length = 266

 Score = 41.4 bits (96), Expect = 0.017,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 24/61 (39%), Gaps = 8/61 (13%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD--------LTTVIENLRKR 201
           + EE  E   A    D      E  D+++ ++ +++             + TV E + +R
Sbjct: 44  LAEEVYELQQALAEKDLENTCEEMGDVLFQIVFIMEIFHDSGQIPMSRVMDTVKEKMIRR 103

Query: 202 H 202
           H
Sbjct: 104 H 104


>UniRef50_D2RFM2 MazG nucleotide pyrophosphohydrolase n=3 Tax=Euryarchaeota
           RepID=D2RFM2_ARCPR
          Length = 96

 Score = 41.4 bits (96), Expect = 0.017,   Method: Composition-based stats.
 Identities = 14/64 (21%), Positives = 27/64 (42%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193
           Y  +    G ++    + EE  E A A   +D   +  E +D+   L+ L     +DL +
Sbjct: 14  YYERDLKRGKEKTMLWLVEEIGELAEAVRKNDLNSIREEMADVFAWLVSLANLYDVDLES 73

Query: 194 VIEN 197
            ++ 
Sbjct: 74  AVKE 77


>UniRef50_C7M0K4 MazG nucleotide pyrophosphohydrolase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0K4_ACIFD
          Length = 430

 Score = 41.4 bits (96), Expect = 0.019,   Method: Composition-based stats.
 Identities = 18/76 (23%), Positives = 30/76 (39%), Gaps = 13/76 (17%)

Query: 140 ASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNEASDLMY----HLLVLLQDQGLD 190
           +   + +A+ + EE  E   A     A  HDR  +  E  D++     H  +  +D   D
Sbjct: 243 SQTHRSLARHLIEEAYEAVDALDAYEADGHDRDHVVEELGDVLLQVLMHATIADEDGSFD 302

Query: 191 LTTVIE----NLRKRH 202
           L  +       L +RH
Sbjct: 303 LIAIARALTDKLIRRH 318


>UniRef50_C1ZK38 MazG family protein n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZK38_PLALI
          Length = 320

 Score = 41.4 bits (96), Expect = 0.019,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 25/73 (34%), Gaps = 12/73 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD------QGLDLTT 193
               K + +   EE  E   A    D   +  E  D++  L V+L        Q  DL  
Sbjct: 61  EQTLKSVCKHTLEETYELIEAIEHDDNIAIVEELGDVL--LQVILDAQIGRDEQRFDLID 118

Query: 194 VIE----NLRKRH 202
           VI      +  RH
Sbjct: 119 VIRGVTAKMIHRH 131


>UniRef50_A9WKS6 MazG n=1 Tax=Renibacterium salmoninarum ATCC 33209
           RepID=A9WKS6_RENSM
          Length = 201

 Score = 41.4 bits (96), Expect = 0.021,   Method: Composition-based stats.
 Identities = 11/64 (17%), Positives = 23/64 (35%), Gaps = 5/64 (7%)

Query: 143 TKRIAQKVGEEGVETALAATVH-DRFELTNEASDLM----YHLLVLLQDQGLDLTTVIEN 197
            + + + + EE  E   A        EL  E  D++     H  +  +     +  V+  
Sbjct: 27  HESLIEYLIEESYEVVEAIEAGKTPAELRGELGDVLLQVVLHARIAEESGQFVIDDVVRG 86

Query: 198 LRKR 201
           L ++
Sbjct: 87  LTEK 90


>UniRef50_D2RLM3 MazG family protein n=1 Tax=Acidaminococcus fermentans DSM 20731
           RepID=D2RLM3_ACIFE
          Length = 270

 Score = 41.0 bits (95), Expect = 0.023,   Method: Composition-based stats.
 Identities = 11/68 (16%), Positives = 27/68 (39%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLD----LTTV 194
            + + +++ EE  E   A    +   +  E  D++    +H  +  ++        +  V
Sbjct: 41  HQSMRRELVEEVYEMLEAIDDGNVAGMREEMGDVLLQVVFHARLAEEEGLFAMQDVIDDV 100

Query: 195 IENLRKRH 202
           ++ L  RH
Sbjct: 101 VKKLVHRH 108



 Score = 40.2 bits (93), Expect = 0.040,   Method: Composition-based stats.
 Identities = 15/49 (30%), Positives = 20/49 (40%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +KV EE  E   A    DR     E  DL + L V  +   L+  T + 
Sbjct: 177 EKVQEEEKELQEAVEACDRDRTEEELGDLFFALAVYARKLDLEPETTLN 225


>UniRef50_A8LHV5 MazG family protein n=9 Tax=Proteobacteria RepID=A8LHV5_DINSH
          Length = 279

 Score = 40.6 bits (94), Expect = 0.029,   Method: Composition-based stats.
 Identities = 16/65 (24%), Positives = 26/65 (40%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT----TVIE 196
               ++  K+ EE  E A A    D  +L  E  DL++ ++ L +  GLD          
Sbjct: 180 DDADQVLAKLAEESAELADARDAGDAAKLHEEFGDLLFVVVNLGRHLGLDPEHALRDANA 239

Query: 197 NLRKR 201
              +R
Sbjct: 240 KFTRR 244



 Score = 40.6 bits (94), Expect = 0.032,   Method: Composition-based stats.
 Identities = 14/66 (21%), Positives = 24/66 (36%), Gaps = 4/66 (6%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + IA    EE  E + A    D  +L +E  DL+    Y   +  +    D   V 
Sbjct: 45  EQTFETIAPYTIEEAYEVSDAIDRGDWADLKSELGDLLLQTVYQTQIGAERGLFDFHDVA 104

Query: 196 ENLRKR 201
             + ++
Sbjct: 105 NGIAQK 110


>UniRef50_C2CLU6 Nucleoside triphosphate pyrophosphohydrolase n=8
           Tax=Corynebacterium RepID=C2CLU6_CORST
          Length = 220

 Score = 40.6 bits (94), Expect = 0.034,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVH-DRFELTNEASD----LMYHLLVLLQDQGLDLTTV 194
           A   + +   + EE  E A A        EL  E  D    +++H  +  +     L  V
Sbjct: 106 AQTHESLLPYLAEESQEFAEAVRERAGDEELCKELGDVLLQVLFHAELASRRGAFTLDDV 165

Query: 195 ----IENLRKR 201
               +  LR R
Sbjct: 166 AVSFVTKLRSR 176


>UniRef50_A9H4J7 Putative uncharacterized protein n=1 Tax=Gluconacetobacter
           diazotrophicus PAl 5 RepID=A9H4J7_GLUDA
          Length = 148

 Score = 40.6 bits (94), Expect = 0.034,   Method: Composition-based stats.
 Identities = 13/64 (20%), Positives = 25/64 (39%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLR 199
               +RIA+  G       +     DR  L  E+++ +  L+ +   + +    V   L 
Sbjct: 53  EQHVRRIARAFGLHAEHCVMELIADDRAALIRESAETLTRLMQIWAARNVSADAVWTELD 112

Query: 200 KRHQ 203
           +R Q
Sbjct: 113 RRTQ 116


>UniRef50_A8V300 Putative uncharacterized protein (Fragment) n=1 Tax=Hydrogenivirga
           sp. 128-5-R1-1 RepID=A8V300_9AQUI
          Length = 187

 Score = 40.6 bits (94), Expect = 0.035,   Method: Composition-based stats.
 Identities = 14/61 (22%), Positives = 25/61 (40%), Gaps = 3/61 (4%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
              ++I  K+ EE  E   A     + EL +E  D++  L+ L +   +D    +     
Sbjct: 87  KNKEQILDKIQEEIKEFKEA---KTKEELKHEFGDILIALVNLARHLDIDPEEALHEATD 143

Query: 201 R 201
           R
Sbjct: 144 R 144


>UniRef50_A6C1Y3 MazG family protein n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C1Y3_9PLAN
          Length = 312

 Score = 40.2 bits (93), Expect = 0.038,   Method: Composition-based stats.
 Identities = 11/48 (22%), Positives = 17/48 (35%), Gaps = 2/48 (4%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
               + I     EE  E   A    +   +  E  DL+  L ++L  Q
Sbjct: 55  EQTLETIKPYTLEETYELLEAIDSGNDEHIIEELGDLL--LQIVLDAQ 100


>UniRef50_B8DJD8 MazG family protein n=8 Tax=Desulfovibrionales RepID=B8DJD8_DESVM
          Length = 287

 Score = 40.2 bits (93), Expect = 0.038,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV---LLQDQG-LDLTTVI 195
               + +A  V EE  E   A       ++  E  D+M+ L     L  D+G   L   +
Sbjct: 35  EQTPESLADYVIEECFELVEAIRSGKVHDVREELGDVMFLLAFIGRLYADKGAFTLADAV 94

Query: 196 ----ENLRKRH 202
                 + +RH
Sbjct: 95  EGNAAKMIRRH 105


>UniRef50_C8QYT7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Desulfurivibrio
           alkaliphilus AHT2 RepID=C8QYT7_9DELT
          Length = 144

 Score = 40.2 bits (93), Expect = 0.038,   Method: Composition-based stats.
 Identities = 12/62 (19%), Positives = 24/62 (38%), Gaps = 8/62 (12%)

Query: 149 KVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL----QDQGLDL----TTVIENLRK 200
            + EE  E   +   +D   +  E  DL++ +L +     +     L      +I  + +
Sbjct: 48  YLLEEAHELHESLGGNDHRHIREELGDLLFQVLFIAELYREQGAFTLSEVINDIIAKMVR 107

Query: 201 RH 202
           RH
Sbjct: 108 RH 109


>UniRef50_C7RKB9 MazG nucleotide pyrophosphohydrolase n=1 Tax=Candidatus
           Accumulibacter phosphatis clade IIA str. UW-1
           RepID=C7RKB9_9PROT
          Length = 97

 Score = 40.2 bits (93), Expect = 0.044,   Method: Composition-based stats.
 Identities = 17/62 (27%), Positives = 26/62 (41%), Gaps = 1/62 (1%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT-VIENL 198
           A G ++      EE  E A A +  +   +  E  D++  L+ L    G DL   V   L
Sbjct: 28  ARGPEKTFLFFVEEVGELATALSRRNAENIEEEIGDVLMWLVSLANLTGTDLRDCVAAYL 87

Query: 199 RK 200
           R+
Sbjct: 88  RR 89


>UniRef50_C5ZZZ8 Beta-lactamase regulatory-like protein, mazg protein n=6
           Tax=cellular organisms RepID=C5ZZZ8_THESM
          Length = 96

 Score = 40.2 bits (93), Expect = 0.046,   Method: Composition-based stats.
 Identities = 16/63 (25%), Positives = 27/63 (42%), Gaps = 4/63 (6%)

Query: 139 YASGTKRIAQK----VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTV 194
           +    KR  +K      EE  E A A   +DR  +  E +D++  L+ L    G+D+   
Sbjct: 15  FHRDEKRGLEKTFLWFSEEIGELAEALRKNDREAMDEEFADVLAWLVSLANIVGVDVEEA 74

Query: 195 IEN 197
            + 
Sbjct: 75  AKK 77


>UniRef50_D1PFK2 MazG family protein n=3 Tax=Prevotella RepID=D1PFK2_9BACT
          Length = 317

 Score = 39.9 bits (92), Expect = 0.056,   Method: Composition-based stats.
 Identities = 14/67 (20%), Positives = 26/67 (38%), Gaps = 8/67 (11%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV----I 195
           + +     EE  E   A    D  ++  E  D++ H++    +  +D   D+  V     
Sbjct: 41  ESLRPNTIEETFELCDALMKRDYKDIKKELGDVLEHVMFYSIIGREDGEFDICDVCNQEA 100

Query: 196 ENLRKRH 202
           + L  RH
Sbjct: 101 DKLMFRH 107


>UniRef50_A4X3B3 MazG nucleotide pyrophosphohydrolase n=4 Tax=Actinomycetales
           RepID=A4X3B3_SALTO
          Length = 328

 Score = 39.9 bits (92), Expect = 0.061,   Method: Composition-based stats.
 Identities = 13/48 (27%), Positives = 21/48 (43%), Gaps = 2/48 (4%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
           A   + +A  + EE  E   A +  D   L  E  D++  L V+L  +
Sbjct: 136 AQTHRSLASFLVEECYEAYDAISAGDTDALREELGDVL--LQVVLHAR 181


>UniRef50_B8G6I9 MazG family protein n=3 Tax=Chloroflexus RepID=B8G6I9_CHLAD
          Length = 408

 Score = 39.5 bits (91), Expect = 0.071,   Method: Composition-based stats.
 Identities = 15/68 (22%), Positives = 26/68 (38%), Gaps = 8/68 (11%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV---LLQDQG-LDLTTVIE-- 196
            + + +   EE  E   A    D   L  E  D++  + V   + +  G   L +V++  
Sbjct: 167 HQSLRRTFLEEVYEALEAIDTGDMRHLCEELGDVLMQVFVHSEMARQAGYFTLESVVQHV 226

Query: 197 --NLRKRH 202
              L  RH
Sbjct: 227 ADKLIFRH 234



 Score = 39.5 bits (91), Expect = 0.077,   Method: Composition-based stats.
 Identities = 17/85 (20%), Positives = 30/85 (35%), Gaps = 9/85 (10%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
                 RK+     ++T        +++  K+ EE  E   A    D      E  DL++
Sbjct: 284 TAQTLARKAIQAGFTWTT------IEQVWAKIAEELAELREA---DDSAAQKRELGDLLF 334

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
            L +L     LD  + +     R +
Sbjct: 335 ALTILAHWLQLDAESALREANLRFK 359


>UniRef50_C2AVJ2 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Tsukamurella paurometabola DSM 20162
           RepID=C2AVJ2_TSUPA
          Length = 321

 Score = 39.5 bits (91), Expect = 0.072,   Method: Composition-based stats.
 Identities = 15/80 (18%), Positives = 26/80 (32%), Gaps = 17/80 (21%)

Query: 140 ASGTKRIAQKVGEEGVETALAA--------TVHDRFELTNEASDLM----YHLLVLLQDQ 187
                 + + + EE  E A A            +R EL +E  DL+    +H  +  +  
Sbjct: 110 EQTHASLLRYLVEETYELADAVSALETSESGDAERAELRSELGDLLLQVIFHARIAQEAS 169

Query: 188 G--LDLTTVIENLR---KRH 202
                +  V   L    +R 
Sbjct: 170 RGPFGIDEVARTLTAKVRRR 189


>UniRef50_UPI000169915B nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Endoriftia
           persephone 'Hot96_1+Hot96_2' RepID=UPI000169915B
          Length = 139

 Score = 39.5 bits (91), Expect = 0.073,   Method: Composition-based stats.
 Identities = 12/64 (18%), Positives = 23/64 (35%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----N 197
               +A K+ EE  E           +   E  DL++  + L +  G+D  + +      
Sbjct: 31  EIGAVADKLREELGEVEAVIAADQAQQREEEIGDLLFSCVNLARHAGVDAESALRSANHK 90

Query: 198 LRKR 201
             +R
Sbjct: 91  FERR 94


>UniRef50_A2BIS9 Mazg nucleotide pyrophosphohydrolase, chain A-conserved archaeal
           protein n=13 Tax=Thermoprotei RepID=A2BIS9_HYPBU
          Length = 100

 Score = 39.5 bits (91), Expect = 0.073,   Method: Composition-based stats.
 Identities = 11/48 (22%), Positives = 18/48 (37%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             EE  E A A    D+  +  E  D++   L +    G+D     + 
Sbjct: 31  FVEEVGELAEALLKGDKNLIAEEIGDVIAWALSIANLVGVDAEEAFKK 78


>UniRef50_C8PQ63 MazG family protein n=1 Tax=Treponema vincentii ATCC 35580
           RepID=C8PQ63_9SPIO
          Length = 312

 Score = 39.5 bits (91), Expect = 0.079,   Method: Composition-based stats.
 Identities = 12/60 (20%), Positives = 21/60 (35%), Gaps = 4/60 (6%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRKRHQ 203
           +K  EE  E   A       E   E  DL++ L+   +   +D    +        +R +
Sbjct: 210 KKTEEELAEFTEALAHGTHEEAEAEFGDLLFSLVNTARHLHIDPAIALSRTNAKFERRFR 269


>UniRef50_A0JU20 MazG family protein n=3 Tax=Arthrobacter RepID=A0JU20_ARTS2
          Length = 236

 Score = 39.1 bits (90), Expect = 0.093,   Method: Composition-based stats.
 Identities = 12/69 (17%), Positives = 24/69 (34%), Gaps = 9/69 (13%)

Query: 143 TKRIAQKVGEEGVETALAATVH-DRFELTNEASDLM----YHLLVLLQDQGLDLTTVI-- 195
            + + + + EE  E A       D  EL  E  D++     H  +  +        V+  
Sbjct: 31  HESLVEYLLEEAFEVAETIETGADEAELRGELGDVLLQVVLHARLAEERGSFGFDDVVQG 90

Query: 196 --ENLRKRH 202
               + +R+
Sbjct: 91  LTAKMIRRN 99


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella ...   249   7e-65
UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bac...   247   1e-64
UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaero...   247   2e-64
UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteri...   246   3e-64
UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisI...   244   2e-63
UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteob...   242   5e-63
UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillon...   242   6e-63
UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteri...   241   9e-63
UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firm...   240   2e-62
UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   239   3e-62
UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cell...   239   5e-62
UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   238   9e-62
UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquific...   238   9e-62
UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   231   1e-59
UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi...   231   1e-59
UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bact...   230   2e-59
UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cell...   230   3e-59
UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   229   6e-59
UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   228   1e-58
UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellul...   227   1e-58
UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natrana...   227   2e-58
UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bac...   227   2e-58
UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Cauloba...   227   3e-58
UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   225   7e-58
UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicycl...   224   1e-57
UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   221   1e-56
UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Therm...   220   1e-56
UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacte...   220   2e-56
UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 ...   219   4e-56
UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain p...   218   8e-56
UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocy...   218   8e-56
UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Therman...   217   2e-55
UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (His...   217   3e-55
UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Prote...   216   3e-55
UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   216   4e-55
UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...   215   1e-54
UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosy...   215   1e-54
UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisI...   214   1e-54
UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (His...   214   1e-54
UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5     214   2e-54
UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   213   2e-54
UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   213   3e-54
UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribos...   213   3e-54
UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellu...   212   5e-54
UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bactero...   212   7e-54
UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria Rep...   212   8e-54
UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI...   212   8e-54
UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   210   3e-53
UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosy...   209   6e-53
UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl...   208   8e-53
UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribos...   206   3e-52
UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 ...   201   9e-51
UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/p...   199   5e-50
UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel...   193   2e-48
UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Sper...   193   2e-48
UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A...   191   1e-47
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   184   2e-45
UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 T...   183   3e-45
UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisI...   181   1e-44
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   176   4e-43
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   175   9e-43
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   170   2e-41
UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellu...   170   3e-41
UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthros...   169   4e-41
UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schiz...   168   1e-40
UniRef50_A0YJX3 Phosphoribosyl-ATP pyrophosphohydrolase:phosphor...   165   7e-40
UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   165   1e-39
UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actin...   163   2e-39
UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacter...   163   2e-39
UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacte...   163   3e-39
UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   163   3e-39
UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthon...   163   5e-39
UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actin...   162   6e-39
UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   162   8e-39
UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacter...   162   9e-39
UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteo...   161   2e-38
UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m...   160   2e-38
UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammap...   160   2e-38
UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   159   4e-38
UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacte...   159   5e-38
UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, pu...   159   6e-38
UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirell...   159   6e-38
UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   158   1e-37
UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   158   1e-37
UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphap...   157   2e-37
UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Prote...   156   4e-37
UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microm...   156   4e-37
UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirsch...   156   5e-37
UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Prote...   156   5e-37
UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosy...   156   5e-37
UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein...   156   6e-37
UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein...   155   6e-37
UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacte...   155   7e-37
UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodob...   155   7e-37
UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Prote...   155   9e-37
UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellul...   155   1e-36
UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   155   1e-36
UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermo...   155   1e-36
UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacte...   154   1e-36
UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudo...   154   2e-36
UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellul...   154   2e-36
UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryar...   154   2e-36
UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacte...   153   2e-36
UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actin...   152   7e-36
UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetob...   152   8e-36
UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax...   151   1e-35
UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Prote...   151   2e-35
UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Altero...   151   2e-35
UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methan...   151   2e-35
UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bact...   150   2e-35
UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax...   149   5e-35
UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellu...   149   5e-35
UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacte...   149   6e-35
UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizob...   148   8e-35
UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root ...   148   9e-35
UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leucon...   148   1e-34
UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacter...   147   2e-34
UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotro...   147   2e-34
UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta p...   147   2e-34
UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=...   147   3e-34
UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphap...   146   4e-34
UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrob...   146   4e-34
UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Prote...   146   4e-34
UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermo...   146   5e-34
UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actin...   146   5e-34
UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellu...   145   8e-34
UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynu...   145   9e-34
UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   144   1e-33
UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythr...   143   2e-33
UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bactero...   143   3e-33
UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphom...   143   4e-33
UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphing...   142   6e-33
UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclo...   141   1e-32
UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methyl...   139   5e-32
UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax...   139   5e-32
UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignico...   133   5e-30
UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Metha...   132   6e-30
UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micros...   130   4e-29
UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydr...   124   1e-27
UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphing...   123   2e-27
UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptos...   122   8e-27
UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfo...   121   1e-26
UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptos...   115   1e-24
UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candid...   113   3e-24
UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 T...   112   6e-24
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   108   2e-22
UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseov...   106   3e-22
UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bact...   103   5e-21
UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellu...   102   7e-21
UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bact...   101   1e-20
UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=...    98   1e-19
UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clost...    98   1e-19
UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collins...    98   1e-19
UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alpha...    98   2e-19
UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomi...    97   5e-19
UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_C...    97   5e-19
UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alph...    97   5e-19
UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Beta...    96   6e-19
UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firm...    96   7e-19
UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betap...    96   7e-19
UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkh...    95   1e-18
UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalk...    95   1e-18
UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostri...    95   1e-18
UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cell...    94   3e-18
UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    94   3e-18
UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alph...    94   3e-18
UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymom...    94   3e-18
UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodo...    94   3e-18
UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Prot...    94   4e-18
UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lacto...    93   5e-18
UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothi...    93   6e-18
UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alph...    93   7e-18
UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Prot...    93   7e-18
UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferrogl...    92   9e-18
UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fra...    92   1e-17
UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...    92   1e-17
UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Ther...    92   1e-17
UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphor...    92   1e-17
UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Metha...    91   2e-17
UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lacto...    91   2e-17
UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncul...    91   2e-17
UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Prot...    91   3e-17
UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alph...    91   3e-17
UniRef50_Q0S4J7 Putative uncharacterized protein n=4 Tax=Nocardi...    90   3e-17
UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Prote...    88   2e-16
UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfu...    87   3e-16
UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Br...    87   3e-16
UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Metha...    87   3e-16
UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    86   1e-15
UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizo...    85   1e-15
UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphin...    85   1e-15
UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvu...    85   1e-15
UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    85   1e-15
UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaerom...    84   2e-15
UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=...    84   3e-15
UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halob...    83   4e-15
UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC...    82   1e-14
UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Eury...    81   1e-14
UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG famil...    81   3e-14
UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius therm...    80   4e-14
UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640...    80   5e-14
UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp....    80   5e-14
UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkalip...    80   5e-14
UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibroba...    80   6e-14
UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bact...    79   8e-14
UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Stre...    79   1e-13
UniRef50_A2CDV8 MazG family protein n=11 Tax=Cyanobacteria RepID...    79   1e-13
UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root Re...    78   1e-13
UniRef50_B3DW98 Predicted pyrophosphatase n=1 Tax=Methylacidiphi...    78   2e-13
UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Acti...    78   2e-13
UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinog...    78   2e-13
UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii K...    78   2e-13
UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepI...    78   2e-13
UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomo...    77   3e-13
UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1...    77   3e-13
UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and Ma...    77   4e-13
UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TB...    77   4e-13
UniRef50_C9XSA1 Putative bifunctional protein [include tetrapyrr...    76   5e-13
UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus...    76   5e-13
UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermo...    76   5e-13
UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX Re...    76   6e-13
UniRef50_UPI0001C36472 MazG family protein n=1 Tax=Clostridium h...    76   6e-13
UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clost...    76   9e-13
UniRef50_A6LPK0 MazG family protein n=10 Tax=Clostridia RepID=A6...    76   1e-12
UniRef50_B0SCK2 Pyrophosphatase n=2 Tax=Leptospira biflexa serov...    76   1e-12
UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    75   1e-12
UniRef50_Q7V9I6 Predicted pyrophosphatase n=1 Tax=Prochlorococcu...    75   1e-12
UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bac...    75   1e-12
UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=...    75   1e-12
UniRef50_P37556 Uncharacterized protein yabN n=95 Tax=Bacillacea...    75   1e-12
UniRef50_Q7D8Z6 Transcriptional regulator, MazG family n=3 Tax=M...    75   1e-12
UniRef50_Q6G3M6 MazG protein n=1 Tax=Bartonella henselae RepID=Q...    75   1e-12
UniRef50_B2TI15 MazG family protein n=5 Tax=Clostridium RepID=B2...    75   2e-12
UniRef50_A0QBX2 Transcriptional regulator, MazG family protein n...    75   2e-12
UniRef50_D2LXK4 MazG family protein n=2 Tax=Bacillus RepID=D2LXK...    75   2e-12
UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha p...    75   2e-12
UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=...    74   3e-12
UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and ...    74   3e-12
UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber D...    74   3e-12
UniRef50_B2UPD1 MazG family protein n=1 Tax=Akkermansia muciniph...    74   3e-12
UniRef50_A9KR53 MazG family protein n=1 Tax=Clostridium phytofer...    74   3e-12
UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Ta...    74   3e-12
UniRef50_C6QD16 MazG family protein n=6 Tax=Proteobacteria RepID...    74   3e-12
UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguob...    74   4e-12
UniRef50_Q3AVT5 MazG n=4 Tax=Cyanobacteria RepID=Q3AVT5_SYNS9          74   4e-12
UniRef50_B8HTG9 MazG family protein n=2 Tax=Chroococcales RepID=...    74   4e-12
UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetip...    74   4e-12
UniRef50_A4J0R1 MazG family protein n=4 Tax=Clostridia RepID=A4J...    74   4e-12
UniRef50_B9XJR1 MazG family protein n=1 Tax=bacterium Ellin514 R...    74   4e-12
UniRef50_A8L147 MazG family protein n=4 Tax=Frankia RepID=A8L147...    73   5e-12
UniRef50_Q28PV1 MazG family protein n=8 Tax=Bacteria RepID=Q28PV...    73   6e-12
UniRef50_B1C9L0 Putative uncharacterized protein n=1 Tax=Anaerof...    73   6e-12
UniRef50_Q04VW6 Pyrophosphatase n=6 Tax=Leptospira RepID=Q04VW6_...    73   6e-12
UniRef50_Q0A8N1 MazG family protein n=4 Tax=Proteobacteria RepID...    73   7e-12
UniRef50_C0AEE9 MazG family protein (Fragment) n=1 Tax=Opitutace...    73   7e-12
UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus...    73   7e-12
UniRef50_B0K4Q4 MazG family protein n=10 Tax=Clostridia RepID=B0...    73   7e-12
UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus...    73   8e-12
UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Str...    72   9e-12
UniRef50_C8WFT9 MazG family protein n=3 Tax=Zymomonas mobilis Re...    72   9e-12
UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Str...    72   1e-11
UniRef50_C0QWZ2 Nucleoside triphosphate pyrophosphohydrolase n=2...    72   1e-11
UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobact...    72   1e-11
UniRef50_C9LLX3 MazG protein n=1 Tax=Dialister invisus DSM 15470...    72   1e-11
UniRef50_B4RXM6 MazG protein n=3 Tax=Proteobacteria RepID=B4RXM6...    72   1e-11
UniRef50_B5JET8 MazG family protein n=1 Tax=Verrucomicrobiae bac...    72   1e-11
UniRef50_B1YGQ0 MazG family protein n=5 Tax=Bacillales RepID=B1Y...    71   1e-11
UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 R...    71   2e-11
UniRef50_B0CCR5 MazG family protein n=8 Tax=Cyanobacteria RepID=...    71   2e-11
UniRef50_C1TQS2 MazG family protein n=3 Tax=Synergistaceae RepID...    71   2e-11
UniRef50_B0TBB1 Mazg family protein n=4 Tax=Bacteria RepID=B0TBB...    71   2e-11
UniRef50_D1PLC7 MazG protein n=3 Tax=Ruminococcaceae RepID=D1PLC...    71   2e-11
UniRef50_Q0B0R5 MazG protein n=1 Tax=Syntrophomonas wolfei subsp...    71   2e-11
UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planc...    71   2e-11
UniRef50_B9CMC9 Tetrapyrrole methylase family protein, MazG fami...    71   2e-11
UniRef50_D0L751 MazG nucleotide pyrophosphohydrolase n=1 Tax=Gor...    71   2e-11
UniRef50_C0GPL2 Type III restriction protein res subunit n=1 Tax...    71   3e-11
UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria ...    71   3e-11
UniRef50_A8ZVD0 MazG family protein n=1 Tax=Desulfococcus oleovo...    71   3e-11
UniRef50_C0QR38 MazG family protein n=4 Tax=Hydrogenothermaceae ...    71   3e-11
UniRef50_A4EC03 Putative uncharacterized protein n=1 Tax=Collins...    70   3e-11
UniRef50_Q1IPL4 MazG family protein n=1 Tax=Candidatus Koribacte...    70   3e-11
UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Metha...    70   4e-11
UniRef50_B6GA15 Putative uncharacterized protein n=2 Tax=Collins...    70   4e-11
UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfo...    70   5e-11
UniRef50_C7MMP1 MazG family protein n=2 Tax=Coriobacteriaceae Re...    70   5e-11
UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID...    70   5e-11
UniRef50_C8W8X4 MazG family protein n=2 Tax=Coriobacteriaceae Re...    70   6e-11
UniRef50_Q3Z619 MazG family protein n=5 Tax=Dehalococcoides RepI...    70   6e-11
UniRef50_B5HJI9 Nucleoside triphosphate pyrophosphohydrolase n=2...    70   6e-11
UniRef50_C0WDQ0 Putative uncharacterized protein n=1 Tax=Acidami...    70   6e-11
UniRef50_C1XVA0 MazG family protein n=2 Tax=Deinococci RepID=C1X...    70   7e-11
UniRef50_A7VWY5 Putative uncharacterized protein n=4 Tax=Clostri...    70   7e-11
UniRef50_D2PPA8 MazG family protein n=2 Tax=Actinomycetales RepI...    70   7e-11
UniRef50_C7R009 MazG family protein n=1 Tax=Jonesia denitrifican...    70   7e-11
UniRef50_D1N5T1 MazG family protein n=1 Tax=Victivallis vadensis...    69   7e-11
UniRef50_Q1K0K7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Des...    69   8e-11
UniRef50_B0MPG5 Putative uncharacterized protein n=1 Tax=Eubacte...    69   8e-11
UniRef50_B1XI42 MazG family protein n=22 Tax=Cyanobacteria RepID...    69   9e-11
UniRef50_B8KRH4 MazG family protein n=1 Tax=gamma proteobacteriu...    69   1e-10
UniRef50_A9FF91 Putative uncharacterized protein mazG n=1 Tax=So...    68   1e-10
UniRef50_P44723 Protein mazG homolog n=57 Tax=Gammaproteobacteri...    68   1e-10
UniRef50_Q2JT55 MazG family protein n=4 Tax=Bacteria RepID=Q2JT5...    68   2e-10
UniRef50_B8D010 MazG family protein n=3 Tax=Bacteria RepID=B8D01...    68   2e-10
UniRef50_C7QJ07 MazG family protein n=7 Tax=Actinomycetales RepI...    68   2e-10
UniRef50_B1GYU5 Putative nucleotide pyrophosphohydrolase MazG n=...    68   2e-10
UniRef50_C1F8P3 MazG family protein n=1 Tax=Acidobacterium capsu...    68   3e-10
UniRef50_D0LI16 MazG family protein n=1 Tax=Haliangium ochraceum...    67   3e-10
UniRef50_D1A7M2 MazG family protein n=8 Tax=Actinomycetales RepI...    67   3e-10
UniRef50_A6G509 MazG family protein n=1 Tax=Plesiocystis pacific...    67   3e-10
UniRef50_B0VJQ1 Nucleoside triphosphate pyrophosphohydrolase n=1...    67   4e-10
UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodo...    67   4e-10
UniRef50_A1SF64 MazG nucleotide pyrophosphohydrolase n=1 Tax=Noc...    66   5e-10
UniRef50_B1J1L8 MazG family protein n=14 Tax=Bacteria RepID=B1J1...    66   5e-10
UniRef50_Q8NRS5 Predicted pyrophosphatase n=4 Tax=Corynebacteriu...    66   5e-10
UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=A...    66   5e-10
UniRef50_D1YB63 MazG family protein n=2 Tax=Propionibacterium ac...    66   7e-10
UniRef50_Q1J066 MazG family protein n=5 Tax=Deinococci RepID=Q1J...    66   7e-10
UniRef50_B5YFB4 MazG n=2 Tax=Dictyoglomus RepID=B5YFB4_DICT6           66   8e-10
UniRef50_P0AEY4 Protein mazG n=179 Tax=Proteobacteria RepID=MAZG...    66   9e-10
UniRef50_B2GM14 Putative uncharacterized protein n=1 Tax=Kocuria...    66   9e-10
UniRef50_C8WQS0 MazG family protein n=2 Tax=Alicyclobacillus aci...    65   1e-09
UniRef50_Q30YJ6 MazG family protein n=6 Tax=Desulfovibrionales R...    65   2e-09
UniRef50_D1W9A9 MazG family protein n=5 Tax=Prevotella RepID=D1W...    65   2e-09
UniRef50_C7RAH4 MazG family protein n=1 Tax=Kangiella koreensis ...    65   2e-09
UniRef50_A8UAP0 Putative uncharacterized protein n=1 Tax=Carnoba...    65   2e-09
UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerth...    64   3e-09
UniRef50_Q2LVG8 MazG-like domain protein n=1 Tax=Syntrophus acid...    64   3e-09
UniRef50_A2BTR6 MazG family protein n=7 Tax=Prochlorococcus mari...    63   4e-09
UniRef50_Q6AK03 Putative uncharacterized protein n=1 Tax=Desulfo...    63   5e-09
UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC...    62   1e-08
UniRef50_C5VBE9 Nucleoside triphosphate pyrophosphohydrolase n=2...    62   1e-08
UniRef50_Q6MDA8 Putative uncharacterized protein n=1 Tax=Candida...    62   1e-08
UniRef50_Q1NJI5 MazG nucleotide pyrophosphohydrolase n=2 Tax=del...    62   1e-08
UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID...    57   4e-07
UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax...    56   9e-07
UniRef50_UPI0001C317DB MazG family protein n=1 Tax=Conexibacter ...    56   1e-06
UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alph...    55   1e-06
UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase...    55   2e-06
UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolas...    54   4e-06
UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax...    52   1e-05
UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frank...    48   2e-04
UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Therm...    45   0.002

Sequences not found previously or not previously below threshold:

UniRef50_B1ZW78 MazG family protein n=1 Tax=Opitutus terrae PB90...    71   1e-11
UniRef50_C8WJX9 MazG family protein n=1 Tax=Eggerthella lenta DS...    68   2e-10
UniRef50_C7JCN1 Nucleotide pyrophosphohydrolase MazG n=8 Tax=Ace...    67   3e-10
UniRef50_A3WPS6 Predicted pyrophosphatase MazG n=2 Tax=Idiomarin...    67   4e-10
UniRef50_A9AYB5 MazG family protein n=1 Tax=Herpetosiphon aurant...    66   5e-10
UniRef50_C0Q9D5 Tetrapyrrole methylase family protein (MazG fami...    66   1e-09
UniRef50_Q5HIH0 Tetrapyrrole methylase family protein n=63 Tax=S...    65   1e-09
UniRef50_D2S938 MazG family protein n=1 Tax=Geodermatophilus obs...    65   1e-09
UniRef50_C1A8D0 Putative nucleoside triphosphate pyrophosphohydr...    65   2e-09
UniRef50_Q3B1B2 MazG n=12 Tax=Chlorobiaceae RepID=Q3B1B2_PELLD         65   2e-09
UniRef50_C6CRL2 MazG family protein n=6 Tax=Firmicutes RepID=C6C...    64   2e-09
UniRef50_B7H015 MazG family protein n=18 Tax=Acinetobacter RepID...    64   3e-09
UniRef50_UPI000197392B MazG family protein n=1 Tax=Clostridium s...    64   3e-09
UniRef50_D2RLM3 MazG family protein n=1 Tax=Acidaminococcus ferm...    64   4e-09
UniRef50_B8G6I9 MazG family protein n=3 Tax=Chloroflexus RepID=B...    63   5e-09
UniRef50_A6C1Y3 MazG family protein n=1 Tax=Planctomyces maris D...    63   5e-09
UniRef50_C1YI03 MazG family protein n=1 Tax=Nocardiopsis dassonv...    63   6e-09
UniRef50_Q65VQ2 MazG protein n=1 Tax=Mannheimia succiniciproduce...    62   9e-09
UniRef50_C7M0K4 MazG nucleotide pyrophosphohydrolase n=1 Tax=Aci...    62   1e-08
UniRef50_B8FGV8 MazG family protein n=1 Tax=Desulfatibacillum al...    62   1e-08
UniRef50_Q6MMY5 Tetrapyrrole methylase family protein/MazG famil...    62   1e-08
UniRef50_Q2SL25 Predicted pyrophosphatase n=20 Tax=Proteobacteri...    62   1e-08
UniRef50_P33653 Uncharacterized 26.1 kDa protein in blaB 3'regio...    62   1e-08
UniRef50_A8LHV5 MazG family protein n=9 Tax=Proteobacteria RepID...    61   2e-08
UniRef50_B9KZD8 Putative tetrapyrrole (Corrin/porphyrin) methyla...    61   3e-08
UniRef50_C0CMG7 Putative uncharacterized protein n=1 Tax=Blautia...    61   3e-08
UniRef50_A5ZV93 Putative uncharacterized protein n=1 Tax=Ruminoc...    61   3e-08
UniRef50_Q6I858 Predicted MazG-family transcriptional regulator ...    61   3e-08
UniRef50_A5CTB1 Putative pyrophosphatase n=4 Tax=Actinobacteria ...    61   3e-08
UniRef50_C1ZK38 MazG family protein n=1 Tax=Planctomyces limnoph...    61   3e-08
UniRef50_C3JX00 Nucleoside triphosphate pyrophosphohydrolase n=1...    60   3e-08
UniRef50_C2AVJ2 Protein with tetrapyrrole methyltransferase and ...    60   4e-08
UniRef50_A9WKS6 MazG n=1 Tax=Renibacterium salmoninarum ATCC 332...    60   4e-08
UniRef50_Q027H8 MazG family protein n=1 Tax=Candidatus Solibacte...    60   5e-08
UniRef50_A0JU20 MazG family protein n=3 Tax=Arthrobacter RepID=A...    60   5e-08
UniRef50_D2NPA3 Predicted pyrophosphatase n=2 Tax=Rothia mucilag...    60   5e-08
UniRef50_C0ES56 Putative uncharacterized protein n=1 Tax=Eubacte...    60   7e-08
UniRef50_C4B7S4 Putative MazG family protein n=1 Tax=Desulfotign...    59   8e-08
UniRef50_D1PFK2 MazG family protein n=3 Tax=Prevotella RepID=D1P...    59   8e-08
UniRef50_C8QYT7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Des...    59   9e-08
UniRef50_A4A3U0 MazG nucleotide pyrophosphohydrolase family prot...    59   1e-07
UniRef50_Q1QX16 MazG family protein n=12 Tax=Proteobacteria RepI...    58   1e-07
UniRef50_Q73KD2 MazG family protein n=1 Tax=Treponema denticola ...    58   1e-07
UniRef50_A0LK91 MazG family protein n=1 Tax=Syntrophobacter fuma...    58   2e-07
UniRef50_B8DJD8 MazG family protein n=8 Tax=Desulfovibrionales R...    58   2e-07
UniRef50_Q0HXH2 MazG family protein n=140 Tax=Proteobacteria Rep...    58   2e-07
UniRef50_D1R6W2 Putative uncharacterized protein n=1 Tax=Parachl...    58   2e-07
UniRef50_A3YTK8 MazG n=1 Tax=Synechococcus sp. WH 5701 RepID=A3Y...    57   4e-07
UniRef50_A4X3B3 MazG nucleotide pyrophosphohydrolase n=4 Tax=Act...    57   4e-07
UniRef50_C3WG55 Nucleoside triphosphate pyrophosphohydrolase n=3...    56   6e-07
UniRef50_B3DSB2 Tetrapyrrole methyltransferase-like protein n=8 ...    56   6e-07
UniRef50_D1SEV4 MazG family protein n=1 Tax=Micromonospora auran...    55   1e-06
UniRef50_C2CLU6 Nucleoside triphosphate pyrophosphohydrolase n=8...    55   1e-06
UniRef50_B2S417 Protein MazG n=2 Tax=Treponema pallidum RepID=B2...    55   2e-06
UniRef50_Q0F3U2 Nucleoside triphosphate pyrophosphohydrolase n=1...    55   2e-06
UniRef50_C6LFH2 MazG protein n=1 Tax=Bryantella formatexigens DS...    55   2e-06
UniRef50_A6TJN3 MazG family protein n=33 Tax=Bacteria RepID=A6TJ...    55   2e-06
UniRef50_Q0FF05 MazG family protein n=3 Tax=Rhodobacterales RepI...    53   8e-06
UniRef50_D2QL02 MazG family protein n=76 Tax=Bacteria RepID=D2QL...    52   1e-05
UniRef50_D1NV29 Transcriptional regulator, MazG family n=3 Tax=B...    52   1e-05
UniRef50_B7AVE3 Putative uncharacterized protein n=1 Tax=Bactero...    52   1e-05
UniRef50_C8PQ63 MazG family protein n=1 Tax=Treponema vincentii ...    52   1e-05
UniRef50_D1CG10 MazG family protein n=1 Tax=Thermobaculum terren...    51   2e-05
UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG fami...    51   3e-05
UniRef50_UPI000185C266 nucleoside triphosphate pyrophosphohydrol...    51   3e-05
UniRef50_C0AY94 Putative uncharacterized protein n=1 Tax=Proteus...    51   3e-05
UniRef50_C8NTB1 MazG family transcriptional regulator n=3 Tax=Co...    50   4e-05
UniRef50_C9KKM0 Tetrapyrrole methylase family protein/MazG famil...    50   4e-05
UniRef50_UPI0000510014 MazG family protein n=1 Tax=Brevibacteriu...    50   5e-05
UniRef50_A5USY4 MazG family protein n=2 Tax=Roseiflexus RepID=A5...    50   7e-05
UniRef50_C7MC77 Protein with tetrapyrrole methyltransferase and ...    48   2e-04
UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus k...    48   2e-04
UniRef50_B1L6A5 MazG nucleotide pyrophosphohydrolase n=2 Tax=Arc...    46   6e-04
UniRef50_D2RFM2 MazG nucleotide pyrophosphohydrolase n=3 Tax=Eur...    46   9e-04
UniRef50_A3EPX0 MazG family protein (Nucleotide pyrophosphohydro...    46   9e-04
UniRef50_C7RKB9 MazG nucleotide pyrophosphohydrolase n=1 Tax=Can...    45   0.001
UniRef50_C5C986 Protein with tetrapyrrole methyltransferase and ...    45   0.001
UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY...    45   0.002
UniRef50_C4LHL5 Putative uncharacterized protein n=1 Tax=Coryneb...    44   0.003
UniRef50_A8ATT3 Gp45 n=1 Tax=Listeria phage P35 RepID=A8ATT3_9CAUD     44   0.004
UniRef50_B7JWE8 MazG nucleotide pyrophosphohydrolase n=2 Tax=Cya...    43   0.006
UniRef50_A2BIS9 Mazg nucleotide pyrophosphohydrolase, chain A-co...    43   0.008
UniRef50_B5Y801 MazG family protein n=1 Tax=Coprothermobacter pr...    43   0.009
UniRef50_C5ZZZ8 Beta-lactamase regulatory-like protein, mazg pro...    42   0.010
UniRef50_Q12UY5 Protein with MazG nucleotide pyrophosphohydrolas...    42   0.012
UniRef50_Q3JCR4 Tetrapyrrole methylase family protein / MazG fam...    42   0.013
UniRef50_D2RFM8 MazG nucleotide pyrophosphohydrolase n=1 Tax=Arc...    42   0.014
UniRef50_D2QAY9 MazG nucleotide pyrophosphohydrolase n=15 Tax=ce...    41   0.017
UniRef50_C8S8Z5 MazG nucleotide pyrophosphohydrolase n=2 Tax=Arc...    41   0.020
UniRef50_C2BZZ6 MazG nucleotide pyrophosphohydrolase n=2 Tax=Lis...    41   0.022
UniRef50_B7GRX0 MazG nucleotide pyrophosphohydrolase n=7 Tax=cel...    41   0.024
UniRef50_O32263 Uncharacterized protein yvdC n=97 Tax=Bacteria R...    41   0.025
UniRef50_B8G452 MazG nucleotide pyrophosphohydrolase n=4 Tax=Bac...    41   0.026
UniRef50_Q94MU3 P26 n=1 Tax=Myxococcus phage Mx8 RepID=Q94MU3_9CAUD    41   0.027
UniRef50_C7PX95 MazG nucleotide pyrophosphohydrolase n=1 Tax=Cat...    41   0.027
UniRef50_B9KBS0 MazG-related protein n=6 Tax=Thermotogaceae RepI...    41   0.028
UniRef50_C4Z5Y7 Putative uncharacterized protein n=1 Tax=Eubacte...    40   0.047
UniRef50_A6VMS4 MazG nucleotide pyrophosphohydrolase n=26 Tax=Ba...    40   0.049
UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax...    40   0.051
UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferro...    40   0.051
UniRef50_Q02X26 Predicted pyrophosphatase n=4 Tax=Lactococcus la...    40   0.062
UniRef50_A8AB92 MazG nucleotide pyrophosphohydrolase n=6 Tax=The...    40   0.062
UniRef50_C8XG56 MazG nucleotide pyrophosphohydrolase n=1 Tax=Nak...    40   0.067
UniRef50_Q4JU45 Putative uncharacterized protein n=2 Tax=Coryneb...    40   0.077
UniRef50_C3PNV1 MazG-like protein n=4 Tax=spotted fever group Re...    39   0.086

>UniRef50_D1PV67 Histidine biosynthesis HisIE n=2 Tax=Prevotella RepID=D1PV67_9BACT
          Length = 215

 Score =  249 bits (635), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 96/196 (48%), Positives = 133/196 (67%), Gaps = 2/196 (1%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++D++K  GL+P ++Q   +  VLMLGYMN EA  KT+E+ KVTF+SR++  LWTKGETS
Sbjct: 2   QIDFDKQGGLVPAVIQDDTTKNVLMLGYMNEEAYQKTIETRKVTFWSRSRNCLWTKGETS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--GDTAHQWLFLYQLEQLLAERK 126
           GN+L++VSI  DCDNDTLLV  +P GPTCH GT +C+   +  +  LFL +L+  +  R 
Sbjct: 62  GNYLSLVSIKSDCDNDTLLVKVHPHGPTCHTGTDTCWGETNRLNPILFLSELQNFIDARH 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
              P+ SYT  L+  G ++IAQKVGEE VET + A   +   L  EASD++YHL+VLL  
Sbjct: 122 EEMPQDSYTTSLFKKGVEKIAQKVGEEAVETIIEAVKGNNDSLVYEASDMIYHLMVLLTS 181

Query: 187 QGLDLTTVIENLRKRH 202
           +GL +  +   L +RH
Sbjct: 182 KGLHIEDLARELARRH 197


>UniRef50_Q7MLS0 Phosphoribosyl-ATP pyrophosphatase n=268 Tax=Bacteria
           RepID=HIS2_VIBVY
          Length = 211

 Score =  247 bits (631), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 128/205 (62%), Positives = 159/205 (77%), Gaps = 3/205 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
                   ++WEK DGL+P IVQ   S +VLM+GYMN +AL KT E+G+VTFFSRTK+RL
Sbjct: 7   EVSSLAERINWEKVDGLVPAIVQDFQSSQVLMMGYMNQDALAKTGETGQVTFFSRTKERL 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ---WLFLYQL 118
           WTKGETSGN L +V+++ DCDNDTLLV  NPIGPTCH GT++C+     +    ++L+QL
Sbjct: 67  WTKGETSGNVLQLVNMSLDCDNDTLLVKVNPIGPTCHTGTTTCWDGDPQEESQMVWLHQL 126

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQLLA RKSADP++SYTA LYA GTKRI+QKVGEEGVE ALAAT  D+ EL  E++DL+Y
Sbjct: 127 EQLLAARKSADPDSSYTASLYARGTKRISQKVGEEGVEVALAATSGDKAELVCESADLIY 186

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           HLLVLLQDQGL +  VI  L++RH+
Sbjct: 187 HLLVLLQDQGLSMNDVINKLKERHK 211


>UniRef50_D1C4Y5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1C4Y5_SPHTD
          Length = 228

 Score =  247 bits (631), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 86/205 (41%), Positives = 121/205 (59%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+P +VQ A +G+V MLGYMN EAL++T+ + ++ F+SR++ +LW KGE
Sbjct: 14  VDAVRFD-ERGLVPALVQDAATGQVRMLGYMNREALERTIATRRLHFWSRSRGKLWMKGE 72

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQ 117
           TSGN   VV I PDCD D LLV   P GPTCH GT +CF                  + +
Sbjct: 73  TSGNVHEVVEIRPDCDGDALLVRVVPAGPTCHLGTDTCFAQPPLMVGEAAVPPTSSVVDE 132

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           + +++AER++   E SYT  L  +G  +I +K+GEE  E  +AA   D   L NEA+DL+
Sbjct: 133 VARVVAERRAHPVEGSYTTYLLTTGIDKIGKKIGEEAAEVIIAAKNADPENLANEAADLI 192

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHLLVLL+   +    V   LR R 
Sbjct: 193 YHLLVLLEASDVPTERVWAVLRTRR 217


>UniRef50_C6PCK8 Phosphoribosyl-ATP diphosphatase n=4 Tax=Bacteria
           RepID=C6PCK8_CLOTS
          Length = 228

 Score =  246 bits (628), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 80/203 (39%), Positives = 118/203 (58%), Gaps = 9/203 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             +L ++   GL+P IVQ   + EVLM+ YMN E+L+K+LE+ +  FFSR++Q LW KGE
Sbjct: 9   IDDLKFD-EKGLIPAIVQDHKTKEVLMMAYMNRESLEKSLENKETYFFSRSRQSLWHKGE 67

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD--------TAHQWLFLYQL 118
           TSGN  ++ +I  DCD DTLLV   P GP CH G +SCF             +   L  L
Sbjct: 68  TSGNVQHIKAIKYDCDGDTLLVEVEPEGPACHTGNNSCFYRDIINDYDENEERESILSNL 127

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + +  RK      SYT  L+  G  +I +K+GEE  E  +A+    + E+  E +D +Y
Sbjct: 128 YRRIESRKENPVTGSYTNYLFEKGLNKILKKIGEENAEIIIASKEDSKEEVVYEIADYIY 187

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           HL+VL+ ++G++L  V + + KR
Sbjct: 188 HLMVLMVEKGINLNDVYKEISKR 210


>UniRef50_Q2JWX9 Histidine biosynthesis bifunctional protein HisIE n=3 Tax=Bacteria
           RepID=Q2JWX9_SYNJA
          Length = 231

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 78/205 (38%), Positives = 108/205 (52%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L +    GL+P IVQ  + G VLM+ +MN E+L KTLE+G+  F+SR++Q LW KGE
Sbjct: 25  LDNLSY-NEQGLIPAIVQDYLDGTVLMMAWMNRESLQKTLETGRTWFWSRSRQALWPKGE 83

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGD--------TAHQWLFLYQ 117
           TSG+   V  I  DCD+D L++L   +G   CH G  SCF                 L Q
Sbjct: 84  TSGHVQWVKQIRYDCDSDALVILVEQVGEAACHTGARSCFFRTLPEKEGDPMPAADTLSQ 143

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           +  ++  R++     SYT+ L A G   I +K+GEE  E  +AA   D+  L  E +DL 
Sbjct: 144 VFAVVKARQADPRPDSYTSSLLAKGDNAILKKLGEETAEVVMAAKEGDKAALAREVADLW 203

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YH LV L    +D+  V   L+ R 
Sbjct: 204 YHCLVALAHHQVDIRDVYRQLQARR 228


>UniRef50_B5EQF3 Phosphoribosyl-ATP diphosphatase n=6 Tax=Proteobacteria
           RepID=B5EQF3_ACIF5
          Length = 230

 Score =  242 bits (619), Expect = 5e-63,   Method: Composition-based stats.
 Identities = 82/209 (39%), Positives = 114/209 (54%), Gaps = 12/209 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W   DGL+P I Q A SG VLML +MN +AL  TL  G  T++SR++Q LW K
Sbjct: 10  AILAAVRW-NADGLVPAIAQDARSGRVLMLAWMNADALLATLRDGLGTYWSRSRQALWRK 68

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----------GDTAHQWL 113
           GETSG+  ++V +  DCD DTLL+     GP CH G  +CF                   
Sbjct: 69  GETSGHIQHLVDLRLDCDGDTLLLRVIQEGPACHTGEQTCFFLGQPGEQGWQHQAPPPGS 128

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L  L+  L  R++ADP  SY A+L   G  RI +KVGEE  E  +A   H+   +  EA
Sbjct: 129 ILDSLQVTLHNRRTADPGQSYVAQLLHGGQDRILKKVGEEATEFVIACKNHESKHIVAEA 188

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL++HL+V L+++ L +  V+  L +R 
Sbjct: 189 ADLVFHLMVALEERDLHIDDVLGELARRE 217


>UniRef50_C4V2J2 Phosphoribosyl-ATP diphosphatase n=2 Tax=Veillonellaceae
           RepID=C4V2J2_9FIRM
          Length = 235

 Score =  242 bits (618), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 78/220 (35%), Positives = 117/220 (53%), Gaps = 22/220 (10%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  +     + ++   GL+P IVQ   + +VLML YMN E+L+KT+E+G   ++SR++Q+
Sbjct: 2   MNVD--MSMIQFD-DRGLVPAIVQE-ENNQVLMLAYMNRESLEKTIETGFAWYYSRSRQK 57

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF--------------- 105
           LW KGETSGN   +  I+ DCD DT+L+     G  CH GT SCF               
Sbjct: 58  LWKKGETSGNVQRIKEISYDCDGDTILLRVKQSGVACHTGTYSCFSGRKLYDADSKSIIP 117

Query: 106 ---GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
               +       L  L Q++  R+    E SYT  L+  G  +I +K+GEE  ET +A+ 
Sbjct: 118 LIEKEEHPLTEVLASLYQVIQNRRLHPVEGSYTNYLFDKGQDKILKKLGEETAETIIASK 177

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            + R ++  E  DL YH LVLL    +    ++E L++R+
Sbjct: 178 NNIREDVLYEMGDLWYHCLVLLAYHNMTPEDLLEELKRRN 217


>UniRef50_C6J1M1 Phosphoribosyl-ATP diphosphatase n=2 Tax=Bacteria
           RepID=C6J1M1_9BACL
          Length = 231

 Score =  241 bits (616), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 92/213 (43%), Positives = 128/213 (60%), Gaps = 13/213 (6%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            E   + + W+   GL+P IVQ A S EVLML YMN E+L K++E+G+  F+SR++  LW
Sbjct: 15  IEALEQTVKWDAA-GLVPAIVQDARSKEVLMLAYMNRESLRKSVETGQTWFWSRSRAELW 73

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------AH 110
            KG TSGN   + ++  DCD DTLLV     GP CH G  +CF  T              
Sbjct: 74  NKGATSGNTQQITALKYDCDGDTLLVEVIANGPACHTGEPTCFYRTAAAASTGSGSGADE 133

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           ++  L +LEQL+AER +  PE +YT  L+  G  +I +KVGEE  E+ +AA   D  EL 
Sbjct: 134 RFKVLAELEQLIAERYTERPEGAYTTYLFEKGLDKILKKVGEETAESIIAAKNGDNDELR 193

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E SDL+YHLLVLL+++ L L  +++ L +RH+
Sbjct: 194 YEVSDLIYHLLVLLRERNLPLDEIMQELERRHE 226


>UniRef50_Q8CXM8 Phosphoribosyl-ATP pyrophosphatase n=12 Tax=Firmicutes
           RepID=HIS2_OCEIH
          Length = 215

 Score =  240 bits (614), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 84/207 (40%), Positives = 120/207 (57%), Gaps = 6/207 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M        L ++   GL+P IVQ   SG+VL L YMN +++ KT+E+ +  F+SR +Q 
Sbjct: 1   MTKSISIEHLQFD-EKGLIPAIVQDHQSGQVLTLAYMNSDSITKTIETNETWFYSRKRQE 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-----LFL 115
           LW KG TSGN   V  I+ DCD D +LVL +  GP CH G  SCF +  ++        +
Sbjct: 60  LWNKGATSGNKQTVKQISFDCDADAVLVLVDAQGPACHTGEESCFYEDLYKNDVALLQII 119

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
            Q+   + ER     E +YT+ L+  G  +I +K+GEE  E  +AA   D+ ELT+E SD
Sbjct: 120 PQVSAKIKERHEHPVEGAYTSYLFEKGVDKILKKIGEEATEVVIAAKNEDKQELTSELSD 179

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRH 202
           L+YH LVL++ QG+ L  + + L KRH
Sbjct: 180 LLYHSLVLMEQQGVTLEDIKKELYKRH 206


>UniRef50_A9B1U1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=A9B1U1_HERA2
          Length = 212

 Score =  239 bits (611), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 104/205 (50%), Positives = 129/205 (62%), Gaps = 10/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             EL ++   GL+P +VQHA SGEVLM+GYMN EAL KT  SG VTF+SR++Q+LWTKGE
Sbjct: 1   MVELTYDS-QGLIPAVVQHARSGEVLMVGYMNAEALAKTQTSGLVTFWSRSRQQLWTKGE 59

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH---------QWLFLYQ 117
           TSGN L  ++   DCDND LL+LA P GPTCH G+ SCF  T              F+ Q
Sbjct: 60  TSGNVLKFIAARTDCDNDALLILAEPTGPTCHTGSRSCFHTTLDGTKREGSAVPLAFVSQ 119

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L + L ER+   P  SYT  L   G  +I +K+GEE  E  +AA   +  EL NEASDL+
Sbjct: 120 LFEFLREREQTRPIGSYTTYLLEKGVDKIGKKIGEESAEVIIAAKNGNADELRNEASDLI 179

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRH 202
           YHL VLL +QG+    V   LR+RH
Sbjct: 180 YHLFVLLLNQGVSPEDVWFTLRERH 204


>UniRef50_Q7U635 Phosphoribosyl-ATP pyrophosphatase n=55 Tax=cellular organisms
           RepID=HIS2_SYNPX
          Length = 222

 Score =  239 bits (609), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 71/214 (33%), Positives = 108/214 (50%), Gaps = 14/214 (6%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L+     +L +    GL+P I Q  + G VLM+ +MN E++ +TL SG+  ++SR++Q L
Sbjct: 4   LSPAFIDQLRF-NEAGLIPAIAQDWLDGAVLMVAWMNRESIQQTLNSGEAHYWSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDT------------ 108
           W KG TSG+   + SI  DCD D LL+     G   CH G  SCF +             
Sbjct: 63  WHKGATSGHTQTLRSIRYDCDADVLLLTIEQRGDIACHTGARSCFYEGGDQRSDGGSNAL 122

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
           +       +L +++  R+    E SYT KL   G  +I +K+GEE  E  +A    +  E
Sbjct: 123 SPPADACTELFRVIESRRDNPEEGSYTNKLLEGGDNKILKKIGEESAEFVMACKDDNPEE 182

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  EA+D+++H+ V L   G+    V E L  R 
Sbjct: 183 IAGEAADILFHMQVALAHHGVSWRQVQEVLAARR 216


>UniRef50_C0QVS5 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=10 Tax=Bacteria
           RepID=C0QVS5_BRAHW
          Length = 220

 Score =  238 bits (607), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 116/205 (56%), Gaps = 6/205 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + + +  +L ++   GL+P IV    + EVL L YMN E+L+ +++  K  F+SR++Q L
Sbjct: 4   INQNEIEKLKFD-DKGLIPAIVIDYYTKEVLTLAYMNKESLEISIKEEKTCFYSRSRQEL 62

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LY 116
           W KGETSGN+ ++ SI  DCDND L++     GP CH G+ SCF +  +         + 
Sbjct: 63  WRKGETSGNYQHIQSIKSDCDNDALVIEVIKDGPACHTGSESCFFNEVYSKEDYKDFSID 122

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +L+  RK    E SYT  L+ SG  +I +KVGEE  E  + A      E   E SDL
Sbjct: 123 KLYKLIEGRKINQTEGSYTTYLFNSGIDKILKKVGEECTEVIIGAKNDSSKETIYELSDL 182

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           +YH LVL+ ++G+ +  +   L  R
Sbjct: 183 LYHSLVLMVEKGITINDIKNELASR 207


>UniRef50_B4U8T9 Phosphoribosyl-ATP diphosphatase n=3 Tax=Aquificaceae
           RepID=B4U8T9_HYDS0
          Length = 207

 Score =  238 bits (607), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 80/205 (39%), Positives = 116/205 (56%), Gaps = 9/205 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+PVI Q A SGE+ ML Y N EA+ KT+E+G   +FSR++  +W KGE
Sbjct: 3   IEDIAFD-EKGLIPVIAQDAFSGEIRMLAYANKEAIKKTIETGYAHYFSRSRNSIWKKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFGDTA-------HQWLFLYQL 118
           TSG    V+ I  DCDNDTL+ +        CH G  +CF             +  L  L
Sbjct: 62  TSGELQEVLEIRLDCDNDTLIYMIKQHKDIACHTGNRNCFFKAFDKEKPSLMPFEILPFL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           E+L+ +R S   E+SYT+KL   G  RI QKVGEE +E+ +A    D+ E+  E +DL+Y
Sbjct: 122 ERLIKDRISNPVESSYTSKLIKEGLDRIVQKVGEEAIESVIAFKNQDKKEIAYELADLIY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRHQ 203
           H+LV ++   +    V   L +RH+
Sbjct: 182 HILVGIKYSNMSFEDVEFELIRRHK 206


>UniRef50_C6N0X1 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Legionella
           RepID=C6N0X1_9GAMM
          Length = 207

 Score =  231 bits (589), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 95/198 (47%), Positives = 131/198 (66%), Gaps = 1/198 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LDW+K +GL+P I+Q+A +G VLMLGYMN EAL  T+ +G++T +SR+++RLW KGE
Sbjct: 6   ISALDWQKMNGLLPAIIQNAENGNVLMLGYMNQEALIATVTTGQLTLYSRSRKRLWRKGE 65

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQLLAER 125
           TSGN + V  I+ DCD+D+LL++  P GP CH G +SC+    H    F+  L +++ ER
Sbjct: 66  TSGNTMAVHHISADCDHDSLLIMVFPKGPACHLGYASCYQPPCHSAISFMSDLIEIINER 125

Query: 126 KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ 185
                E SYTA+L ASG  R AQKVGEE VET +AA      E  NE +DL++HLLVLL+
Sbjct: 126 AETQAENSYTAQLLASGINRCAQKVGEEAVETVIAAVNSTPEEFINECADLVFHLLVLLK 185

Query: 186 DQGLDLTTVIENLRKRHQ 203
              L    V++ L+ R +
Sbjct: 186 ASELSFYDVLQCLQDRDR 203


>UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3
           Tax=Clostridiales RepID=C4Z9Z2_EUBR3
          Length = 427

 Score =  231 bits (589), Expect = 1e-59,   Method: Composition-based stats.
 Identities = 72/213 (33%), Positives = 111/213 (52%), Gaps = 12/213 (5%)

Query: 1   MLTEQQRRELDWE----KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSR 56
           +L +    +L W      +DG++PVIVQ   + +VLML YMN EA + T+ SG++T++SR
Sbjct: 215 ILVDNFTPDLKWSDLKLNSDGMVPVIVQDYRNEQVLMLAYMNEEAFNVTINSGRMTYWSR 274

Query: 57  TKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-------- 108
           ++  LWTKG TSG+   V S+  DCD DT+L   + +G  CH    +CF +         
Sbjct: 275 SRNELWTKGLTSGHLQYVKSLTADCDYDTILAKVSQVGAACHTCNRTCFFNNIVKKEYVE 334

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            +    L  +  ++ +R     E SYT  +   G   I +K+G E  E  LAA   D  +
Sbjct: 335 KNPLTVLESVYAVIVDRMKNPKEDSYTNAVMEKGIDEILKKLGHECTEIILAAKNPDSDD 394

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           L  E SD MYH ++L+  + +    +   L +R
Sbjct: 395 LKFEISDFMYHCMILMAQKNITWAEIAGELAQR 427


>UniRef50_Q8P9N8 Phosphoribosyl-ATP pyrophosphatase n=53 Tax=Bacteria
           RepID=HIS2_XANCP
          Length = 206

 Score =  230 bits (587), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 115/199 (57%), Positives = 135/199 (67%), Gaps = 2/199 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                LDW K DGL+PVIVQ A +  VLMLGYMN EAL  T   G+VTFFSR+KQRLWTK
Sbjct: 10  DALDALDWNKGDGLLPVIVQDADNLRVLMLGYMNAEALAVTRARGEVTFFSRSKQRLWTK 69

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GE+SGN L VV+I  DCD DTLLV A P GPTCH G +SCF        FL  L+ L+AE
Sbjct: 70  GESSGNVLRVVAIETDCDADTLLVQARPHGPTCHLGRTSCFPTA--PSQFLGSLDALIAE 127

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R+   P  SYT KL+  G +RIAQKVGEEGVETALA  V    EL  E++DL+YHL+VLL
Sbjct: 128 REHERPHGSYTTKLFEQGIRRIAQKVGEEGVETALAGVVQGDAELLGESADLLYHLIVLL 187

Query: 185 QDQGLDLTTVIENLRKRHQ 203
           + +GL L   +  L  RH+
Sbjct: 188 RARGLGLGDAVALLESRHK 206


>UniRef50_Q9RPQ3 Phosphoribosyl-ATP pyrophosphatase n=65 Tax=cellular organisms
           RepID=HIS2_THEP3
          Length = 216

 Score =  230 bits (586), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 79/215 (36%), Positives = 114/215 (53%), Gaps = 22/215 (10%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E   +EL ++   GL+PVI Q   + EVLM+ Y+    L K+LE+GKV +FSR++ +LW 
Sbjct: 2   ENILKELKFD-DRGLIPVITQDYKTNEVLMMAYIMKRPLKKSLETGKVHYFSRSRNKLWL 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA-------------- 109
           KGETSG+F  + SI+ DCD DTLL+    +   CH G  SCF                  
Sbjct: 61  KGETSGHFQLIKSISIDCDADTLLIKVEQVEAACHTGHYSCFYREISGNELKETSDKVFD 120

Query: 110 -------HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
                       L ++  ++ +R     E SYT  L+  G  +I +KVGEE  E  + A 
Sbjct: 121 EQKVYEAENAKILQEIYDVIVDRTIHPKEGSYTNYLFEKGLDKILKKVGEEAAEVIIGAK 180

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             D+ E+  E SDL+YHLLVL+ ++G+ L  + E 
Sbjct: 181 NRDKGEIVYEISDLIYHLLVLMVERGIKLEDIYEE 215


>UniRef50_C3XEW8 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=3 Tax=Helicobacter RepID=C3XEW8_9HELI
          Length = 244

 Score =  229 bits (583), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 85/218 (38%), Positives = 113/218 (51%), Gaps = 27/218 (12%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + W+   GL+P I Q ++S EVLML YMN EAL+ TL++G   +FSR+KQR+W KGE SG
Sbjct: 6   IAWDN-KGLIPCITQDSISNEVLMLAYMNEEALNLTLQTGIAHYFSRSKQRIWKKGEQSG 64

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ------------------ 111
           N   V  I  DCD+D++L+  N  G  CH G  SCF                        
Sbjct: 65  NIQEVCEIKLDCDSDSILLRVNQKGVACHTGEFSCFFKNIDSINKDCATTRQESLETTKD 124

Query: 112 --------WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV 163
                   +  L  L   L ERK+AD  TSYTA L+A GT  IA+K+ EE  E   A   
Sbjct: 125 SLTHSLNTYDTLDTLYHTLLERKNADSTTSYTASLFAKGTNAIAKKIIEEAGEFCFALKD 184

Query: 164 HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            D  E+  E +D+ YH+LV L  + +    + + L KR
Sbjct: 185 RDSKEIIYECADVFYHILVGLASENIHPDRIYQELIKR 222


>UniRef50_B7DRK3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius LAA1 RepID=B7DRK3_9BACL
          Length = 254

 Score =  228 bits (581), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 77/250 (30%), Positives = 115/250 (46%), Gaps = 49/250 (19%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           +  + +   + ++   GL+PV+ Q A +GEVLM+ Y + EAL +TL +G   ++SR+++ 
Sbjct: 4   VKGDVELARVRYDSATGLVPVVCQDAETGEVLMVAYADREALKRTLATGYAWYWSRSRRE 63

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G  +CF               
Sbjct: 64  YWRKGATSGNAQRVVEVRIDCDGDAVLYRVVPEGPACHTGERTCFYRRLVPDGAPSEAAD 123

Query: 109 --------------------------------AHQWLFLYQLEQLLAERKSADPETSYTA 136
                                                 L +L  ++  R    P+ SYT 
Sbjct: 124 EGGAKDVGGGADVRGNEAAAVSDTSGEVPGSAPWDESALTRLWGVIDSRYRERPDGSYTT 183

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQDQGLDL 191
            L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL +  G+  
Sbjct: 184 YLFTHGAERMGKKIGEEAVEVALAGMKAERDAAAKTEVASESADLLYHLLVLWRHVGVHP 243

Query: 192 TTVIENLRKR 201
             V   L KR
Sbjct: 244 VDVWRTLEKR 253


>UniRef50_C9RV77 Phosphoribosyl-ATP diphosphatase n=13 Tax=cellular organisms
           RepID=C9RV77_GEOSY
          Length = 216

 Score =  227 bits (580), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 97/204 (47%), Positives = 129/204 (63%), Gaps = 10/204 (4%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
            ++ ++   GL+P IVQ A S EVL L YMN E+L+KTLE+G+  F+SR++Q LW KG T
Sbjct: 3   ADIRFD-EKGLVPAIVQDAQSKEVLTLAYMNKESLEKTLETGETWFYSRSRQELWHKGAT 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT---------AHQWLFLYQL 118
           SGN   VV I  DCD D LLVL  P GP CH G+ SCF  +         A ++  L +L
Sbjct: 62  SGNVQRVVDIRYDCDADALLVLVEPAGPACHTGSYSCFSRSLDGAARTPAADRFAILNEL 121

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
           EQ++A+R +  PE SYT  L+  G  +I +KVGEE  E  +AA   +  EL  EA+DL+Y
Sbjct: 122 EQIIAKRDAERPEGSYTTYLFEKGVDKILKKVGEEAAEVIIAAKNQNHEELKWEAADLLY 181

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVLL++Q L L  V+  L +RH
Sbjct: 182 HLLVLLREQKLPLDAVLATLAERH 205


>UniRef50_B2A6W9 Phosphoribosyl-ATP diphosphatase n=1 Tax=Natranaerobius
           thermophilus JW/NM-WN-LF RepID=B2A6W9_NATTJ
          Length = 211

 Score =  227 bits (579), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 88/203 (43%), Positives = 119/203 (58%), Gaps = 14/203 (6%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             DGL+P I Q A +GEVLML YM+ EA +KT ESG + F+SR+KQRLW KGE+SGN L 
Sbjct: 6   SQDGLIPCIAQDANTGEVLMLAYMSQEAFEKTRESGSLWFWSRSKQRLWQKGESSGNTLI 65

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF--------------LYQLE 119
           V S+  DCD DTLL L  P GP CH G +SCF +   +                 L  L 
Sbjct: 66  VTSLKLDCDKDTLLALVEPQGPACHTGETSCFFNEVTRTDDSRNYRFDDRSSNGILNTLN 125

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           QL+ +R    P+ SY  KL   G  ++ +KVGEE  E   A    D+ E+ +E++DL++H
Sbjct: 126 QLIEQRLEEQPDNSYIIKLTNKGENQVLKKVGEEATELVTACKDEDKKEIIHESADLIFH 185

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L+ L+   +DL+ V++ L  RH
Sbjct: 186 TLLALKYFQVDLSEVLQELHNRH 208


>UniRef50_Q7VQW4 Phosphoribosyl-ATP pyrophosphatase n=103 Tax=Bacteria
           RepID=HIS2_BLOFL
          Length = 213

 Score =  227 bits (578), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 110/208 (52%), Positives = 150/208 (72%), Gaps = 5/208 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT ++ + L+W K  GL+P I+QH++SGEVLMLGYMN E++  T ++G VTFFSR+K R
Sbjct: 1   MLTTEKYQGLNWSKNHGLIPAIIQHSISGEVLMLGYMNQESMAITEKTGYVTFFSRSKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGE+SGN L +++  PDCD D+LL+L  P G TCHK T+SCF      + FL+QLE 
Sbjct: 61  LWIKGESSGNVLKLINWYPDCDFDSLLILVLPQGFTCHKNTNSCFHPALTDFSFLFQLEN 120

Query: 121 LLAERKSA-----DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
           +++ +K+      + ++SYT+ LY SG +RIAQKVGEEG+ETALAA   +   L +EASD
Sbjct: 121 IISIKKNHTSSHGNQQSSYTSDLYTSGIERIAQKVGEEGLETALAAVSRNSKSLIDEASD 180

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L+YHLLVLLQ + L+   VI+ LR R +
Sbjct: 181 LIYHLLVLLQHESLNFHDVIQELRVRSK 208


>UniRef50_C5SM65 Phosphoribosyl-ATP diphosphatase n=2 Tax=Caulobacteraceae
           RepID=C5SM65_9CAUL
          Length = 215

 Score =  227 bits (578), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 108/202 (53%), Positives = 134/202 (66%), Gaps = 1/202 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           LT      LD+ K DGL+P IVQ A + +VLMLGYM+  AL +TL   +VTFFSR+K   
Sbjct: 11  LTLADIDALDFTKGDGLIPAIVQDADTLQVLMLGYMDRAALTETLTDRQVTFFSRSKNGR 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ-WLFLYQLEQ 120
           W KGETSG+FLN+VS+  DCD D LLVLA P+GPTCH  T+SCFG        F+  L  
Sbjct: 71  WRKGETSGDFLNLVSVTTDCDEDALLVLARPVGPTCHTKTTSCFGHDTAPGIGFMGHLAA 130

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
           ++ +R  A P  SYTA+L   G  +IAQKVGEEG+ETALA    D  EL NEA+DL+YHL
Sbjct: 131 VVKDRAKAPPADSYTARLMQKGVAKIAQKVGEEGLETALAGRCGDLDELHNEAADLLYHL 190

Query: 181 LVLLQDQGLDLTTVIENLRKRH 202
            VLL  +   L  V++ LR+RH
Sbjct: 191 SVLLMARDTTLEAVLDILRERH 212


>UniRef50_D2MIV8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=1 Tax=Candidatus Poribacteria
           sp. WGA-A3 RepID=D2MIV8_9BACT
          Length = 234

 Score =  225 bits (574), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 77/205 (37%), Positives = 113/205 (55%), Gaps = 14/205 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           + ++   GL+P +VQ    G +LML YMN EALD+TL++G V F+SR++++LW KGETSG
Sbjct: 16  IQFD-ERGLVPAVVQDWRDGAILMLAYMNREALDQTLQTGYVHFWSRSRRKLWKKGETSG 74

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-------------LFLY 116
           ++L    +  DCD D LLV A P GPTCH    +CF                        
Sbjct: 75  HYLLCKRVFLDCDGDVLLVKAEPTGPTCHTNARTCFFAEVTSRGVTTTQVGEEANGGIFD 134

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L +++ +RK+   E SY + L   G  RI +KV EE  E  LA     R E+ +E +DL
Sbjct: 135 RLYEMVLQRKAQPQEHSYVSALMKDGPDRILKKVVEEAGEVVLAVKKXHREEVIHEVADL 194

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKR 201
           ++H +V L    + +T + + L KR
Sbjct: 195 IFHSIVALGHCEIPMTAIQQELGKR 219


>UniRef50_C8WUY1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WUY1_ALIAD
          Length = 256

 Score =  224 bits (572), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 79/255 (30%), Positives = 116/255 (45%), Gaps = 54/255 (21%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  + +   + ++   GL+PV+ Q A +G+VLML Y + EAL +TL +G   ++SR+++ 
Sbjct: 1   MKGDVELARVRYDAATGLVPVVAQDAETGDVLMLAYADREALKRTLATGYAWYYSRSRRA 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------------ 108
            W KG TSGN   VV +  DCD D +L    P GP CH G   CF               
Sbjct: 61  YWRKGATSGNVQRVVEVRLDCDGDAVLYRVVPEGPACHTGEQVCFYRRLVPDGVSSEAAD 120

Query: 109 -------------------------------------AHQWLFLYQLEQLLAERKSADPE 131
                                                A     L +L  ++  R    P+
Sbjct: 121 ESGPDPHGAAGAGEGDAPAASDADAASDVSVDVSGGAAWDESALARLWGVIDSRYRERPD 180

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLLQD 186
            SYT  L+  G +R+ +K+GEE VE ALA    +R      E+ +E++DL+YHLLVL + 
Sbjct: 181 GSYTTYLFTHGAERMGKKIGEEAVEVALAGVKAERDAAAKAEVASESADLLYHLLVLWRH 240

Query: 187 QGLDLTTVIENLRKR 201
            G+    V + L KR
Sbjct: 241 VGVQPADVWQVLEKR 255


>UniRef50_A4CLC1 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=4 Tax=Flavobacteriales
           RepID=A4CLC1_9FLAO
          Length = 206

 Score =  221 bits (563), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 88/203 (43%), Positives = 124/203 (61%), Gaps = 6/203 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            + +D+EKT GL+P I+Q + +  VLMLGYM+ EAL+ T  SGKVTF+SR+K+RLWTKGE
Sbjct: 1   MKSIDFEKTGGLVPAIIQDSNTRAVLMLGYMDAEALEATKSSGKVTFYSRSKKRLWTKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           +SGNFL  V +  DCD D LL+ A P GP CH G+ +C+ +            + +   +
Sbjct: 61  SSGNFLEFVDVRVDCDGDALLIRARPTGPVCHTGSDTCWDEANPGDEDFLPELEAIIASR 120

Query: 127 SADPET------SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
               +T      SY A L   GT ++AQKVGEE VET + A   D     NE++DL++H 
Sbjct: 121 KEQADTPGGEANSYVAGLLRRGTAKVAQKVGEEAVETVIEAMGSDDNRFLNESADLLFHW 180

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           L+LLQ +G  +  +   L +RH+
Sbjct: 181 LILLQAKGFRMADIERLLAERHR 203


>UniRef50_Q9X0C5 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Thermotoga
           RepID=HIS2_THEMA
          Length = 197

 Score =  220 bits (562), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 84/194 (43%), Positives = 113/194 (58%), Gaps = 8/194 (4%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L PV+VQ   +GEVLML Y N EAL+ T ++G   FFSR +Q++W KGETSGN + VV I
Sbjct: 4   LYPVVVQERTTGEVLMLAYANEEALELTKKTGYAHFFSRERQKIWKKGETSGNTMRVVEI 63

Query: 78  APDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAHQWL------FLYQLEQLLAERKSAD 129
             DCD+D  L + +       CH G  SCF    H++       F  +L +L+ +RK   
Sbjct: 64  RRDCDDDAYLYIVDFPEDKVACHTGNRSCFFKVEHRFEETGSPTFWLELYRLVRKRKEEM 123

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
           PE SYT KL+  G  +IA+K GEE VE       +DR  L  E +D+MYHL VL+ D G+
Sbjct: 124 PEGSYTVKLFKEGKGKIAKKFGEEAVEVITGYLQNDRENLVWEIADMMYHLTVLMADAGV 183

Query: 190 DLTTVIENLRKRHQ 203
            +  V+  L KR +
Sbjct: 184 TVQDVMRELEKRRK 197


>UniRef50_O67780 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Bacteria
           RepID=HIS2_AQUAE
          Length = 205

 Score =  220 bits (562), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 75/206 (36%), Positives = 116/206 (56%), Gaps = 10/206 (4%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             +L +   +GL+PVI Q   +GEV ML Y N EA+ KTLE+G   ++SR+++++W KGE
Sbjct: 1   MLKLKF-NEEGLIPVIAQDYRTGEVRMLAYANEEAIKKTLETGYAHYYSRSRKKIWKKGE 59

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFGDT--------AHQWLFLYQ 117
           TSG    V+ +  DCD D L+ +        CH G  +CF              +  L +
Sbjct: 60  TSGELQKVIEVRVDCDEDALIYVIEQEKDRACHTGERNCFFRDIEGNKVEKPLPFEVLPR 119

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           L+ ++ E+     E SYTAKL + G +R+ QK GEE VET +A    ++ E+  E++D++
Sbjct: 120 LQDVIREKIERKEENSYTAKLVSQGKERVFQKFGEEAVETLIALMKGEKEEVIYESADML 179

Query: 178 YHLLVLLQDQGLDLTTVIENLRKRHQ 203
           Y  LV L   G+D+  V+E L +R +
Sbjct: 180 YTFLVSLSVSGIDIKEVMEELIRRFK 205


>UniRef50_Q67KI1 Histidine biosynthesis bifunctional protein n=1 Tax=Symbiobacterium
           thermophilum RepID=Q67KI1_SYMTH
          Length = 210

 Score =  219 bits (559), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 76/199 (38%), Positives = 99/199 (49%), Gaps = 23/199 (11%)

Query: 27  VSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTL 86
            +G+VLM  YMN EAL  TLE+G   ++SR++Q LW KG TSG+   V  I  DCD D+L
Sbjct: 2   RTGQVLMQAYMNEEALRLTLETGYAWYWSRSRQELWQKGGTSGHVQRVREIRTDCDGDSL 61

Query: 87  LVLANPIGPTCHKGTSSCFGD-----------------------TAHQWLFLYQLEQLLA 123
           L+L    G  CH+GT SCF                                L +L  +LA
Sbjct: 62  LLLVEQEGVACHEGTYSCFTRRVDGSPKALIDTAFWPIQPDDTVPYDIGSILRELTAVLA 121

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ER++     SYT++L+  G     +K+GEE  E  LA    DR  L  E +DL +H LV 
Sbjct: 122 ERRAHPDPESYTSRLFRRGPDAYCKKIGEEATEVVLAVKNRDRENLAFEVADLWFHSLVA 181

Query: 184 LQDQGLDLTTVIENLRKRH 202
           L DQGL    V + L  R 
Sbjct: 182 LVDQGLSPADVADQLASRR 200


>UniRef50_B4W8G4 Phosphoribosyl-ATP pyrophosphohydrolase domain protein n=1
           Tax=Brevundimonas sp. BAL3 RepID=B4W8G4_9CAUL
          Length = 207

 Score =  218 bits (556), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 100/202 (49%), Positives = 134/202 (66%), Gaps = 4/202 (1%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M+       +D+EK +GL+PV+VQ A + +VL L YM+  ALD+T++SG+ TFFSR++  
Sbjct: 1   MIDP---AAIDFEKGNGLVPVVVQDAATLQVLTLAYMDRAALDETIQSGEATFFSRSRGG 57

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-LFLYQLE 119
            W KGETSG+ L+VV I  DCD+D L++  NP+G  CH   +SCFG         + +LE
Sbjct: 58  RWRKGETSGDRLHVVGITADCDSDALVLSVNPVGDACHLHRTSCFGAADAPGLGRIARLE 117

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           Q +AER +ADP  S+TAKL   G KRIAQKVGEEGVETALA       EL +EA+DL+YH
Sbjct: 118 QTIAERAAADPSESWTAKLMTQGVKRIAQKVGEEGVETALAGVAGPDEELASEAADLIYH 177

Query: 180 LLVLLQDQGLDLTTVIENLRKR 201
           LLVLL  + +    V++ L  R
Sbjct: 178 LLVLLHARNMVFQDVLDVLASR 199


>UniRef50_D0LRT4 Phosphoribosyl-ATP diphosphatase n=2 Tax=Nannocystineae
           RepID=D0LRT4_HALO1
          Length = 241

 Score =  218 bits (556), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 83/204 (40%), Positives = 115/204 (56%), Gaps = 16/204 (7%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P +VQ A +G V MLG+MN EAL +TL+SG V F+SR++Q LW KGE+SGN L 
Sbjct: 21  NEHGLLPAVVQDASAGGVRMLGWMNAEALARTLDSGFVHFYSRSRQTLWMKGESSGNTLA 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------TAHQWLFLYQL 118
           V  +  DCD D ++V+A P GPTCH GT SCF                 +      L +L
Sbjct: 81  VRELRVDCDRDAIVVVAEPAGPTCHTGTRSCFFRVLGTGGAVSGEDQGPSEPPVSVLPKL 140

Query: 119 EQLLAERKS-ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
           E ++A R+  AD E SYT  L   G  +I  K+ EE  E A      +R E+ +E +DL+
Sbjct: 141 EGVIAARRDSADAEKSYTKSLLERGFPKILAKIAEEHGELAEVLAEGERGEVVHETADLL 200

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           +H++V L  + + L  V   L +R
Sbjct: 201 FHVMVGLAARDIALDEVWGELSRR 224


>UniRef50_D1B858 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B858_THEAS
          Length = 205

 Score =  217 bits (554), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 94/201 (46%), Positives = 119/201 (59%), Gaps = 6/201 (2%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             ++W   D L+PV+VQ A SG VLML Y N EALD TL+ G+  FFSR++ RLW KGET
Sbjct: 3   DRIEWGNED-LLPVVVQSARSGRVLMLAYANREALDLTLDRGEAWFFSRSRGRLWRKGET 61

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD-----TAHQWLFLYQLEQLL 122
           SGN + V+ +  DCD D++L L    GP CH G  SCF            LFL++L +++
Sbjct: 62  SGNTMRVLEVRLDCDGDSILYLVEESGPACHTGERSCFHRVLKGSGGEACLFLHRLAEIV 121

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +R S   + SYT  L+  G  RIAQKVGEEGVE ALA    DR     EA+DL+YHL V
Sbjct: 122 DQRISRGDQGSYTRSLWERGASRIAQKVGEEGVEVALAVATMDRERAVEEAADLLYHLTV 181

Query: 183 LLQDQGLDLTTVIENLRKRHQ 203
            L+     L    + L  RHQ
Sbjct: 182 ALRRVDATLLDAEQVLMARHQ 202


>UniRef50_C6HYU6 Histidine biosynthesis bifunctional protein (HisIE) n=1
           Tax=Leptospirillum ferrodiazotrophum RepID=C6HYU6_9BACT
          Length = 230

 Score =  217 bits (552), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 85/206 (41%), Positives = 117/206 (56%), Gaps = 8/206 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +       +   + L PV+ Q    G+VLM+GYMN EA  +T+E G+VTFFSR+++RLWT
Sbjct: 2   DDAILRTLFPDGETLRPVVAQEVRFGKVLMVGYMNREAFHRTVEEGRVTFFSRSRKRLWT 61

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------DTAHQWLFL 115
           KGE+SG+FL +VS+  DCD DTLL L  P GPTCH GT SCF         +    +  L
Sbjct: 62  KGESSGHFLRLVSLRYDCDGDTLLALVRPEGPTCHTGTESCFDGRLLVPGTEGRPAFETL 121

Query: 116 YQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD 175
             L   +A R+  DPETSY A+L +     + +K+ EE  ET  A    D     +E +D
Sbjct: 122 GDLAGTIALRRDGDPETSYVARLLSGPRSALLKKLVEEAGETMAAIYEEDAAGTRSEMAD 181

Query: 176 LMYHLLVLLQDQGLDLTTVIENLRKR 201
           L++HLLV ++        V+  L KR
Sbjct: 182 LLFHLLVAMERTRTPWEEVVGVLEKR 207


>UniRef50_Q7VJ02 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Proteobacteria
           RepID=HIS2_HELHP
          Length = 231

 Score =  216 bits (551), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 113/217 (52%), Gaps = 20/217 (9%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +   R++DWE+ + L+P IVQ   S ++LML Y + ++L+ +L++    +FSR+KQR+W 
Sbjct: 2   QDVFRQIDWERYE-LIPTIVQEKQSQQILMLAYSSKQSLELSLQTHLAHYFSRSKQRIWQ 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD---------------- 107
           KGE SG+  ++  +  DCDND+L+ +   +G  CH G  SCF                  
Sbjct: 61  KGEQSGHIQHIKEVKLDCDNDSLIFIVEQVGVACHTGEKSCFFRIFSLDKNCQNPPVSMP 120

Query: 108 ---TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                  +  L  L  ++ +R+  + E SYTA L A G   I +K+ EE  E   A    
Sbjct: 121 QKYPIGVYHILDDLYHIIEQRRCENIEHSYTASLLAKGVNGIGKKIIEEAGELCFALKDK 180

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           D   +  E +DL YH+LV L  + +    V++ LR+R
Sbjct: 181 DEKAIIYECADLFYHILVGLALEHITPERVLQELRRR 217


>UniRef50_A7I395 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=5 Tax=Campylobacter RepID=A7I395_CAMHC
          Length = 251

 Score =  216 bits (550), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 80/233 (34%), Positives = 117/233 (50%), Gaps = 40/233 (17%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+PV++Q   +GEVLM+ YMN EAL+ T  +G   +FSR+K R+W KGE+S
Sbjct: 7   KIDWQKV-GLLPVVIQDNTTGEVLMMAYMNEEALNLTFSTGFAHYFSRSKNRIWKKGESS 65

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT-----------------AHQ 111
           GN   V S   DCDNDTLL+     G  CH G  SCF +                    +
Sbjct: 66  GNTQKVCSAFLDCDNDTLLLKVEQKGAACHTGHKSCFFNEISLNDGEIPHEKNEKISKPK 125

Query: 112 WLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF--- 167
           +  L +L  +  +RK +ADP+ SY AKLY  G     +K+ EE  E A A     R    
Sbjct: 126 YEILDELYHICLDRKFNADPKNSYVAKLYEKGENTHLKKICEEASEFAFACKDLSRAKNY 185

Query: 168 ------------------ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                             ++  E +DL++H++V L   G+    ++  L +R+
Sbjct: 186 RDLKREIFGEHHENEPEYDVIYEGADLLFHMVVALAYHGIHPENLLNELSRRN 238


>UniRef50_C1TLB5 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Dethiosulfovibrio peptidovorans
           DSM 11002 RepID=C1TLB5_9BACT
          Length = 188

 Score =  215 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 88/187 (47%), Positives = 114/187 (60%), Gaps = 5/187 (2%)

Query: 22  IVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDC 81
           +VQ A SGEVLML Y N E++  TLE G++ F+SR+++ +W KG TSGN L + S+  DC
Sbjct: 2   VVQDADSGEVLMLAYGNEESMRLTLERGEMVFYSRSRKEIWHKGMTSGNRLPLASLQIDC 61

Query: 82  DNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL-----FLYQLEQLLAERKSADPETSYTA 136
           D D +L   +P+GP CH G  SCF    H        FL +L   L +R    PE SYTA
Sbjct: 62  DCDAVLARVHPMGPACHTGKISCFYRFIHGNDDDSPVFLGRLWAYLKKRSQDSPEESYTA 121

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           +L A    R+AQK+GEEGVETALA    DR +   EA+DL+YHLLV L    L    +  
Sbjct: 122 RLIAGPKSRVAQKIGEEGVETALAIATEDRKQTIYEAADLVYHLLVGLLASDLSPGEIWR 181

Query: 197 NLRKRHQ 203
            L+KRH+
Sbjct: 182 ELKKRHK 188


>UniRef50_C1XQD4 Phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP
           pyrophosphatase n=3 Tax=Deinococci RepID=C1XQD4_9DEIN
          Length = 215

 Score =  215 bits (547), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 84/204 (41%), Positives = 114/204 (55%), Gaps = 8/204 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             E+ ++  +GL+PVIVQ AVSG+VL L Y N EAL KTLE+ + TF+SR++  LW KG 
Sbjct: 3   IEEVHFD-ANGLVPVIVQDAVSGQVLTLAYANREALAKTLETRQSTFWSRSRGELWVKGA 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW-------LFLYQLE 119
            SGN   V+ +  DCD D +L    P GP CH G  +CF                L ++ 
Sbjct: 62  ISGNTQEVLEVVLDCDQDAVLYRVIPTGPACHTGAETCFHHPVTAETAPPPLGEVLEKVY 121

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
           + L  R    PE SY  K++ +G  RI +K+GEE  E  +AA    R EL  EASDL++H
Sbjct: 122 RTLRSRLRERPEGSYVVKMHDAGLDRILKKIGEEAGEVIIAAKNGSREELAWEASDLLFH 181

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           LL  L + GL    +   L +R+Q
Sbjct: 182 LLFTLTELGLSPQDLARVLWERNQ 205


>UniRef50_B9KXC5 Histidine biosynthesis bifunctional protein hisIE n=3
           Tax=Chloroflexi RepID=B9KXC5_THERP
          Length = 218

 Score =  214 bits (546), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 85/206 (41%), Positives = 121/206 (58%), Gaps = 9/206 (4%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +    + +   DGL+P+IVQ A +G+V M+GY+N +A+ +T+E+G+V F+SR++QRLW K
Sbjct: 8   RLLGAIRF-GADGLVPLIVQDATTGQVRMVGYVNADAVRRTVETGRVHFWSRSRQRLWMK 66

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------DTAHQWLFLY 116
           GETSG+ L +V +  DCD D LL   +P GPTCH G  SCF                 L 
Sbjct: 67  GETSGHVLELVELRTDCDGDALLARVHPHGPTCHTGRPSCFDTEPLVGTSQDPVNATILD 126

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +L  ++A R       SYT+ L  +G  RIA+K+GEE  E  +AA   +   +  EA+DL
Sbjct: 127 ELASIIAARAVEPQPGSYTSALLQAGVDRIARKIGEEAAEVIVAAKNGEPEAIAQEAADL 186

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRH 202
           +YHLLVLLQ  G+    V   L+ R 
Sbjct: 187 LYHLLVLLQASGVPAGEVWRVLQARR 212


>UniRef50_A3EUM3 Histidine biosynthesis bifunctional protein (HisIE) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EUM3_9BACT
          Length = 233

 Score =  214 bits (546), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 91/209 (43%), Positives = 128/209 (61%), Gaps = 8/209 (3%)

Query: 2   LTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTK 58
           L+E++   +  E   G   L+P +VQH  +G+VLMLGYM  EA + T  +GKVTFFSR++
Sbjct: 7   LSEKEILSVAEENAFGKADLIPAVVQHWETGKVLMLGYMTREAYEMTKRTGKVTFFSRSR 66

Query: 59  QRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF-----GDTAHQWL 113
           +++W KGETSGN L+V+ I  DCD DT+LVLA P+GPTCH G+ SCF           + 
Sbjct: 67  KKIWVKGETSGNGLDVMDIRWDCDQDTILVLAKPLGPTCHTGSISCFDGSGLQGKKPPFE 126

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
              +L+  + ERK+ DP+ SYTA L  S    + +K+ EE  E +LA  V  R    +E 
Sbjct: 127 VWSELQSTVRERKTGDPDISYTASLLQSEVSVVLKKLSEESFEVSLATLVESRDRQLSEW 186

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL +H+ V L+  G+    V+E LRKR 
Sbjct: 187 ADLFFHIAVALEKTGVSWGEVMEILRKRQ 215


>UniRef50_A9GR78 HisIE protein n=2 Tax=Bacteria RepID=A9GR78_SORC5
          Length = 229

 Score =  214 bits (544), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 79/199 (39%), Positives = 105/199 (52%), Gaps = 15/199 (7%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+P +VQ  ++G+V ML YM  E+L +TLE+G+ TFFSR++  LW KG TSGN L V S+
Sbjct: 10  LVPAVVQDRLTGQVRMLAYMTRESLARTLETGRATFFSRSRGELWEKGATSGNTLAVTSV 69

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL--------------- 122
             DCD D LL+LA P GPTCH G++SCF                                
Sbjct: 70  HADCDGDALLILAEPRGPTCHTGSASCFFRQVDARGDGEPEAADEGQDASALLESLEREL 129

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
             RK++    SYT KL   G   I  K+ EE  E A A        + +EA+D++YHLLV
Sbjct: 130 EARKASSATKSYTRKLLDGGAPLIGAKLREEAGELAQAIAGESDERVASEAADVIYHLLV 189

Query: 183 LLQDQGLDLTTVIENLRKR 201
            L  +G+ L  V+  L  R
Sbjct: 190 GLASRGVPLRAVLSALASR 208


>UniRef50_Q6KZD6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Picrophilus torridus
           RepID=Q6KZD6_PICTO
          Length = 204

 Score =  213 bits (543), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 73/199 (36%), Positives = 110/199 (55%), Gaps = 13/199 (6%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DG++PV+VQ   +G+VL L YM+  AL+ T+++G   ++SR+ +R+  KGE SGN   V
Sbjct: 9   NDGIVPVVVQDFDTGDVLTLAYMDRNALEMTMKTGYAFYYSRSMKRIHMKGEVSGNTQKV 68

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AHQWLFLYQLEQLLAE 124
           + I  DC++++LL+     GP CH G +SCF              +    L +LE L+ +
Sbjct: 69  MEIYQDCNDNSLLIKVKKDGPACHTGNNSCFYRKLGEPKVDGNIDYSLEILLRLEDLVRK 128

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R       SYT  L  SG + I +KVGEE +ET LA     R  +  E +DL+YHL+V L
Sbjct: 129 RMKDPVNGSYTNYLIDSGDENIRKKVGEEAIETILA---SGRDRIVYETADLLYHLIVFL 185

Query: 185 QDQGLDLTTVIENLRKRHQ 203
               + L  V+  L +R +
Sbjct: 186 AFNNVSLFDVMNELNRRSK 204


>UniRef50_P62350 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_THET2
          Length = 214

 Score =  213 bits (543), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 81/202 (40%), Positives = 119/202 (58%), Gaps = 6/202 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              + ++   GL+PV+VQ A +GEVL L Y N EAL++TL + + TFFSR++Q LW KGE
Sbjct: 3   LSAVRFD-EKGLVPVVVQDARTGEVLTLAYANREALEETLRTRRSTFFSRSRQALWRKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF-----LYQLEQL 121
           TSG+   VV +  DCD D ++    P GP CH G  +CF     +        + Q+   
Sbjct: 62  TSGHTQEVVEVLLDCDGDAVVYRVLPQGPACHTGERTCFHRALLEGEKDLGFVVGQVYAT 121

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
           + ER    PE SY A+++ +G  RI +K+GEE  E  LAA   +  EL +EA+DL++HLL
Sbjct: 122 IKERLRTLPEGSYVARMHHAGLDRILKKIGEEAGEVILAAKNQNPEELRHEAADLLFHLL 181

Query: 182 VLLQDQGLDLTTVIENLRKRHQ 203
           + L + GL    + + L +RH+
Sbjct: 182 LTLAELGLTPEDLAKTLWERHR 203


>UniRef50_Q058A1 Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP
           pyrophosphohydrolase n=1 Tax=Buchnera aphidicola str. Cc
           (Cinara cedri) RepID=Q058A1_BUCCC
          Length = 205

 Score =  213 bits (543), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 93/204 (45%), Positives = 132/204 (64%), Gaps = 1/204 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           ML +Q  + L+W K +GL+P I QH +SGE+LM GYMN +A DK + +   T +SR K+R
Sbjct: 1   MLIDQNLQNLNWTKNNGLIPAIAQHYISGEILMFGYMNQKAFDKMISNKLFTLYSRKKKR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAH-QWLFLYQLE 119
           +W KGETS NFL V +I+ DCD D +LV  NP G TCH    SCF  +    + FLY+LE
Sbjct: 61  IWIKGETSKNFLYVKNISTDCDTDVILVKVNPAGNTCHLNRFSCFESSHQLPYTFLYKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
             +  +K     +SY + L++SG  RIAQK+GEE VE  +A   ++   + NE SDL++H
Sbjct: 121 NRIRNKKENFSRSSYVSNLFSSGNNRIAQKIGEESVEVIIAFLENNHVNIINETSDLIFH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRHQ 203
           L +LLQ   ++L  +I+NL+KR +
Sbjct: 181 LFILLQSMNINLYKIIKNLQKRVK 204


>UniRef50_P58853 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=cellular organisms
           RepID=HIS2_PYRFU
          Length = 209

 Score =  212 bits (541), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 90/213 (42%), Positives = 124/213 (58%), Gaps = 14/213 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M  E+   +++WEK +G++PVIVQ    GEVL L YMN EAL KTLE+G   ++SR+K R
Sbjct: 1   MEIEKLLEQVNWEKNNGIVPVIVQDEK-GEVLTLAYMNKEALRKTLETGIAHYYSRSKGR 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT----------AH 110
           +  KGE SGN   V  I  DCDND LL++ +P GP CH G  SCF              +
Sbjct: 60  IRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDY 119

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
               L +LE+++  RK    E SYT+KL+  G ++I +K GEE +E  +A     R  + 
Sbjct: 120 SLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLVAEK---RERII 176

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            E +DL+YHLLVLL    + L  V+  LR+R +
Sbjct: 177 YEVADLLYHLLVLLTYNDISLGEVMNELRRRRK 209


>UniRef50_C6W0Y7 Phosphoribosyl-ATP diphosphatase n=3 Tax=Bacteroidetes
           RepID=C6W0Y7_DYAFD
          Length = 213

 Score =  212 bits (540), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 103/211 (48%), Positives = 132/211 (62%), Gaps = 12/211 (5%)

Query: 5   QQRRELDWEK-TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    +D+ K  DGL+P ++Q   +G+VLMLGYMN EALD T + G VTFFSR+KQRLWT
Sbjct: 3   ETFSSIDFNKSADGLVPAVIQDVNTGKVLMLGYMNAEALDVTRQQGTVTFFSRSKQRLWT 62

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ------ 117
           KGETSGNFL V  IA DCD DTLL+ A P GP CH G  +CFG+   Q            
Sbjct: 63  KGETSGNFLFVNEIAADCDGDTLLIKATPAGPVCHTGADTCFGEKNSQPEIADTRAGEAA 122

Query: 118 -----LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                 ++++ ERK    + SYT+ L+  G  +IAQKVGEE VE  + +   D     NE
Sbjct: 123 FLNYLQKEVIRERKLNPSDESYTSSLFKRGINKIAQKVGEEAVEVVIESKDSDDDLFKNE 182

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            SDL++HLLVLL+ + +DL  VI+ LR RHQ
Sbjct: 183 VSDLLFHLLVLLEQKNIDLDEVIDVLRSRHQ 213


>UniRef50_B0VLT2 Bifunctional protein n=33 Tax=Proteobacteria RepID=B0VLT2_ACIBS
          Length = 257

 Score =  212 bits (539), Expect = 8e-54,   Method: Composition-based stats.
 Identities = 80/244 (32%), Positives = 115/244 (47%), Gaps = 43/244 (17%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M   Q   E+ +    GL+P I QH  +G +LM+ +MN E+L  T E  +  +FSR++Q+
Sbjct: 1   MNNTQWLDEVKF-NEQGLIPAIAQHHQTGRILMVAWMNRESLALTAEKNQAVYFSRSRQK 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLF----- 114
           LW KGE SG+F  V  I  DCD D +++     G   CH G  SCF        +     
Sbjct: 60  LWHKGEESGHFQTVYEIRLDCDGDVIVLQVEQHGGIACHTGRESCFYRKLTPQGWEIVDA 119

Query: 115 -----------------------------LYQLEQLLAERKSADPETSYTAKLYASGTKR 145
                                        L  L QL+ ERK A+ +TSY + LY  G  +
Sbjct: 120 QLKDPTAIYGDNAKTESHDHAHTNEQVDVLAHLGQLMQERKQAEADTSYVSSLYKKGINK 179

Query: 146 IAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           I +KVGEEGVET +AA          +  +L  E +DL +H +V+L    L+   +I+ L
Sbjct: 180 ILEKVGEEGVETIIAAKDYAAQNTESNLNDLIYETADLWFHSIVMLGYFDLNPQLIIDEL 239

Query: 199 RKRH 202
            +R 
Sbjct: 240 GRRQ 243


>UniRef50_A6Q6T8 Histidine biosynthesis bifunctional protein HisI n=1 Tax=Sulfurovum
           sp. NBC37-1 RepID=A6Q6T8_SULNB
          Length = 222

 Score =  212 bits (539), Expect = 8e-54,   Method: Composition-based stats.
 Identities = 73/207 (35%), Positives = 107/207 (51%), Gaps = 17/207 (8%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSG 69
           +DW K + L+P I Q A + +VLML YMN EA + TL +G   +FSR+KQR+W KGE+SG
Sbjct: 3   IDWNK-NPLIPAIAQDAQTNDVLMLAYMNKEAYELTLSTGYAHYFSRSKQRIWKKGESSG 61

Query: 70  NFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG--------------DTAHQWLFL 115
           +   V  +  DCD DT+++     G  CH G  SCF               DT   +  +
Sbjct: 62  HTQEVKDVLLDCDADTVILKIKQNGVACHTGRKSCFFTSVLQDRVILDKEVDTDAIYGVV 121

Query: 116 YQLEQLLAERKSADPE-TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEAS 174
             L   + ERK+A  E  S+T KL     + +  K+ EE  E  +A       ++  E++
Sbjct: 122 DTLYHTILERKNASAEQKSWTKKLL-DDKELMLSKIREEADEVCVAIDEESDEQVIYESA 180

Query: 175 DLMYHLLVLLQDQGLDLTTVIENLRKR 201
           DL+YH LV L  + +    V + L +R
Sbjct: 181 DLLYHTLVGLGYREISPDRVKQELARR 207


>UniRef50_Q1D4M6 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase
           n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D4M6_MYXXD
          Length = 202

 Score =  210 bits (535), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 70/198 (35%), Positives = 102/198 (51%), Gaps = 5/198 (2%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              LD+ K +GL+ V+ Q A +G+VLM+ + + EAL++TL +G++ + SRT+   W KG 
Sbjct: 4   LDALDFAKGNGLVTVVTQDASTGDVLMVAHADREALERTLATGEMHYRSRTRGP-WHKGA 62

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSGN   VV++  DCD D +L      GP CH GT +CFG      L             
Sbjct: 63  TSGNVQRVVALRADCDGDAVLARVAKAGPACHLGTKTCFGPGRWDALSALDDTLARRAAP 122

Query: 127 SADPET---SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +  P+    SYT +L         +K+GEE  E   A    D      EA+D++YH+LV 
Sbjct: 123 AERPDDAPPSYTRRLLE-DRNLRLKKLGEEAAELVTACADVDPSRAAEEAADVLYHVLVA 181

Query: 184 LQDQGLDLTTVIENLRKR 201
           ++  GL L  V   L +R
Sbjct: 182 VRPLGLSLDDVKAVLARR 199


>UniRef50_B0TY40 Phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP
           cyclohydrolase n=2 Tax=Francisella philomiragia
           RepID=B0TY40_FRAP2
          Length = 207

 Score =  209 bits (532), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 102/204 (50%), Positives = 138/204 (67%), Gaps = 3/204 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +  +    + W+K D L+P I+Q A+   VLMLGYM+ E+L+KTLE GKVTF+SR+K+RL
Sbjct: 1   MDNKIIESIAWQKMDNLVPAIIQSAIDNSVLMLGYMSKESLEKTLEIGKVTFYSRSKKRL 60

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL--FLYQLE 119
           WTKGE SGNFL +  IA DCDND++L+ A P GPTCH G+ SCF           + +LE
Sbjct: 61  WTKGEESGNFLELKDIAVDCDNDSILIKAIPYGPTCHTGSKSCFTKNEENSSLYIIDKLE 120

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF-ELTNEASDLMY 178
           +L+AE+K   PE SY   L+  G  RIAQKVGEEGVE  +AA   D   EL +E +DL++
Sbjct: 121 KLIAEKKDYLPENSYLTSLFKKGLPRIAQKVGEEGVEVVIAAMKQDSEDELISETADLLF 180

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           HLLVLL+++G+ L  + + L  R+
Sbjct: 181 HLLVLLREKGISLEQICQKLVSRN 204


>UniRef50_C1A4L5 Phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4L5_GEMAT
          Length = 207

 Score =  208 bits (530), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 79/204 (38%), Positives = 112/204 (54%), Gaps = 5/204 (2%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M +      LD+ K +GL+ V+ Q A SG VLM+ + + EAL+ TL +G++ + SR++  
Sbjct: 1   MNSTLDLDALDFSKGNGLVTVVTQDARSGVVLMVAHADREALEYTLRTGEMHYRSRSRG- 59

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KG TSG+   V+S+A DCD D +L      GP CH GT+SCF DTA     +  L+ 
Sbjct: 60  LWHKGATSGHVQRVISLAADCDADAVLARVISAGPACHDGTTSCFRDTALAADVIGALDT 119

Query: 121 LLAERKSADPET---SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM 177
            +A R+ +  +    SYT +L         +K+GEE VE A A    D    T E +DL+
Sbjct: 120 TIAARQQSLRDDERPSYTQRLLT-DRNLRLKKLGEEAVELATACVDGDVERATEETADLL 178

Query: 178 YHLLVLLQDQGLDLTTVIENLRKR 201
           YH LV L+  G  L  V   L +R
Sbjct: 179 YHALVALRATGGTLDGVRGVLAQR 202


>UniRef50_C7NG19 Phosphoribosyl-ATP pyrophosphatase /phosphoribosyl-AMP
           cyclohydrolase n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NG19_KYTSD
          Length = 244

 Score =  206 bits (525), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 95/222 (42%), Positives = 123/222 (55%), Gaps = 31/222 (13%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
            +   GL+  +VQ A +  VLM+G+M+  AL+ T  +G+VTF+SR++   W KGETSGN 
Sbjct: 22  TDAGRGLVAAVVQDADTLAVLMVGWMDAAALEATQATGRVTFWSRSRGEQWVKGETSGNT 81

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD------------------------ 107
           L+VVS+  DCD D +LV+A P GPTCH G +SCF                          
Sbjct: 82  LDVVSVHLDCDADAVLVVARPAGPTCHTGAASCFDAASRAGAEAAGAGGEAAASGAGGDA 141

Query: 108 -------TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
                  T      +  L + +AER    P  SYT  L+  GT+RIAQKVGEEGVETALA
Sbjct: 142 PASEIGATDAPASEIGHLARTIAERHRERPAGSYTTSLFEGGTRRIAQKVGEEGVETALA 201

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                  EL  E++DL+YHL+VLL D+GL L  V   LR R 
Sbjct: 202 GVAQGDEELLGESADLLYHLVVLLTDRGLSLADVEAVLRSRR 243


>UniRef50_Q6UA38 Histidine biosynthesis bifunctional protein n=1 Tax=Buchnera
           aphidicola (Chaitophorus populeti) RepID=Q6UA38_9ENTR
          Length = 204

 Score =  201 bits (512), Expect = 9e-51,   Method: Composition-based stats.
 Identities = 91/203 (44%), Positives = 125/203 (61%), Gaps = 1/203 (0%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT  Q  +L+W+K + L+P+IVQ   S E+LM GY N ++L  TL+  K+TFFSRTK R
Sbjct: 1   MLTISQILDLNWDKVNNLIPIIVQDVFSNEILMHGYANKKSLLITLKKKKLTFFSRTKNR 60

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LWTKGETS N+L V+ I PDCD D+LL L   IG TCH    SCF    +  +      +
Sbjct: 61  LWTKGETSKNYLKVIDIIPDCDQDSLLALVQAIGNTCHLNNKSCFKKKKNINVSFILELE 120

Query: 121 LLAE-RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            + +  K  +  TSYT+ LY  G  +I+QKVGEE VE  +AA   D+  +  E +DL+YH
Sbjct: 121 RILKYYKKNNNSTSYTSNLYKKGINKISQKVGEEAVELVIAAINKDKKNMLEECADLIYH 180

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
           +LVL     +    +I+ L+KR+
Sbjct: 181 ILVLFSYTNIPFIDLIKILKKRN 203


>UniRef50_A8HTA8 Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Chlamydomonas reinhardtii
           RepID=A8HTA8_CHLRE
          Length = 308

 Score =  199 bits (506), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 73/226 (32%), Positives = 116/226 (51%), Gaps = 31/226 (13%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L W+K + L+ VIVQH  +GEV+M  + +  A+ +TL++G  TF+SR++   W K
Sbjct: 67  SFLDSLKWDKNN-LVAVIVQHIDTGEVMMQAFADRAAISETLQTGLATFYSRSRGGRWCK 125

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGD----------------- 107
           GETSG+F+NV ++  DCD D+++ L++PIGP CH G  +C+                   
Sbjct: 126 GETSGHFINVFNVFTDCDRDSIIYLSDPIGPACHTGARTCWFKEVELQGQEGAAVSHAGA 185

Query: 108 -----TAHQWLFLYQLEQLLAERKSAD------PETSYTAKLYASGTKRIAQKVGEEGVE 156
                       L  LE+ +A+R+ A        + S+TA+L     + + +K+ EE  E
Sbjct: 186 HDDGGDHVPRTTLLTLERTIAQRREAMKLPSDGSKPSWTARLL-GNPELLCKKIREEAGE 244

Query: 157 TALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                     R    +E +DL+YH +VL   QG+ +  V+  LRKR
Sbjct: 245 LCQTLEADEGRERAASEMADLLYHAMVLCNLQGVAMEDVLRVLRKR 290


>UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM
           16069 RepID=C7RAI7_KANKD
          Length = 412

 Score =  193 bits (492), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 69/201 (34%), Positives = 104/201 (51%), Gaps = 6/201 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L E     LD++K   L+P IVQ   +G VLML Y  PE+L   +   K  +FSR++  L
Sbjct: 216 LDEAVMACLDFDKAP-LIPTIVQDVDTGSVLMLAYSTPESLQAAMTQKKGIYFSRSRNEL 274

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG TSGN   +++I  DCD DTL+      G  CH    SCF   +  +  L  L+++
Sbjct: 275 WEKGLTSGNQQQLINIDYDCDGDTLVFKVKQKGNACHFDRYSCFAGQSANFD-LDVLDRV 333

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
             +R  +   TS++ KL AS      +K+ EE  E   A    D+ E+  EA+DL++  L
Sbjct: 334 FEQRMQSQEVTSFSQKLLASD-DLQQEKLREECEELIEA---DDQDEVRWEAADLIFFAL 389

Query: 182 VLLQDQGLDLTTVIENLRKRH 202
              + +G+  + +I  L  R+
Sbjct: 390 ARAKSKGVAASDIINELGARN 410


>UniRef50_O82768 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Spermatophyta
           RepID=HIS2_ARATH
          Length = 281

 Score =  193 bits (492), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 73/219 (33%), Positives = 112/219 (51%), Gaps = 21/219 (9%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +     + W+   GL   I Q+  +G VLM G++N EAL  T+ S K TFFSR++  L
Sbjct: 51  KVDNLLDRIKWD-DKGLAVAIAQNVDTGAVLMQGFVNREALSTTISSRKATFFSRSRSTL 109

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW--------- 112
           WTKGETS NF+N++ +  DCD D+++ L  P GPTCH G  +C+  +             
Sbjct: 110 WTKGETSNNFINILDVYVDCDRDSIIYLGTPDGPTCHTGEETCYYTSVFDQLNNDEASGN 169

Query: 113 ----LFLYQLEQLLAERKSADP-----ETSYTAKLYASGTKRIAQKVGEEGVETALAAT- 162
                 LY LE ++++RK         + S+T +L       +  K+ EE  E       
Sbjct: 170 KLALTTLYSLESIISKRKEESTVPQEGKPSWTRRLLTDD-ALLCSKIREEADELCRTLED 228

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             +     +E +D++YH +VLL  +G+ +  V+E LRKR
Sbjct: 229 NEEVSRTPSEMADVLYHAMVLLSKRGVKMEDVLEVLRKR 267


>UniRef50_A4RVN0 Predicted protein n=12 Tax=Viridiplantae RepID=A4RVN0_OSTLU
          Length = 284

 Score =  191 bits (486), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 70/221 (31%), Positives = 110/221 (49%), Gaps = 25/221 (11%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                 L ++   GL+  I Q   +G +LM G+ + +A+  TL + K TF+SR++  LW 
Sbjct: 44  NAFLDSLKYD-DKGLVCAIAQDVDTGAILMQGFASRDAVAYTLRNRKATFWSRSRSELWC 102

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL---------- 113
           KGETSGNF+ V S+  DCD D+L+ L  P GPTCH G  +C+                  
Sbjct: 103 KGETSGNFIGVESVHVDCDRDSLIYLGVPTGPTCHTGAHTCYYKRVDGRDGAAAKVDGGR 162

Query: 114 --------FLYQLEQLLAERKSA----DPETSYTAKLYASGTKRIAQKVGEEGVETALA- 160
                    LY+LE  +  R+      D + S+T +L     + + +K+ EE  E     
Sbjct: 163 HAAEEALTTLYELEATIEARRVEAVADDVKPSWTRRLL-DNPELLCKKIREEAGELCQTW 221

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                +   TNE +D++YH +V+L  QG+ ++ V+  LR+R
Sbjct: 222 EENEGKEAATNEMADVLYHSMVMLNKQGVPMSDVLAVLRRR 262


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  184 bits (467), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 66/203 (32%), Positives = 103/203 (50%), Gaps = 9/203 (4%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLT++   E+  ++ DGL   +V        L L Y + +++ K ++ G+  ++SR++  
Sbjct: 134 MLTKEVLGEVRTDRPDGLYTTLVVDQYE-RCLGLVYSSKKSIAKAIDLGRGVYYSRSRNE 192

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLE 119
           +W KGETSGN   ++ I+ DCD+D L  +        CH  T SCFG+  H  + L    
Sbjct: 193 IWIKGETSGNGQKLLQISTDCDSDALKFIVEQENVGFCHLETMSCFGEFKHGLVGLES-- 250

Query: 120 QLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH 179
            LL +R    PE SYT +L+ + +  +  K+ EE  E   A     + EL+ EA+DL Y 
Sbjct: 251 -LLKQRLQDAPEESYTRRLF-NDSALLDAKIKEEAEELTEA---KGKKELSWEAADLFYF 305

Query: 180 LLVLLQDQGLDLTTVIENLRKRH 202
            L  L    + L  V  NL  +H
Sbjct: 306 ALAKLVANDVSLKDVENNLNMKH 328


>UniRef50_B8BUA9 Probable phosphoribosyl-amp cyclohydrolase n=1 Tax=Thalassiosira
           pseudonana RepID=B8BUA9_THAPS
          Length = 272

 Score =  183 bits (465), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 58/199 (29%), Positives = 95/199 (47%), Gaps = 13/199 (6%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            +  ++ DGL   +V    SGE L L Y + E++   L+SG+  ++SR++  LW KG+TS
Sbjct: 58  CVKTDRGDGLYTTVV-STRSGEALGLVYSSKESIVAALQSGRGVYYSRSRNGLWRKGDTS 116

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIG----PTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           G+F  +  +  DCD D L       G      CH  T +C+G+       L  LE  L +
Sbjct: 117 GHFQTLHRLDVDCDGDALRFTVTQRGDDIRAFCHLNTLTCWGEP----RGLRHLEGTLQQ 172

Query: 125 RKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL 184
           R    P  SYT +L+      +  K+ EE  E + A     +  +  E +D++Y  +V  
Sbjct: 173 RLKDAPVGSYTKRLFEDEI-LLRDKLVEEAQELSEA---DTKQHVAEELADVLYFAMVRA 228

Query: 185 QDQGLDLTTVIENLRKRHQ 203
              G+ +   +E L +R +
Sbjct: 229 AKAGVSIDDAVEELDRRTR 247


>UniRef50_B9D5P8 Histidine biosynthesis bifunctional protein hisIE n=2
           Tax=Campylobacter RepID=B9D5P8_WOLRE
          Length = 329

 Score =  181 bits (460), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 70/186 (37%), Positives = 96/186 (51%), Gaps = 29/186 (15%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P +VQ + SGEVLML YMN EAL+ +L++G   +FSRTK R+W KGE S
Sbjct: 2   KIDWKKVGGLLPAVVQESSSGEVLMLAYMNEEALNLSLKTGFAHYFSRTKNRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGD-------------------- 107
           GN   +  I  DCDNDT+L+     G   CH G  SCF                      
Sbjct: 62  GNTQAIDEIFLDCDNDTILLKVVQNGGVACHTGAKSCFFRKISGDGDESNLTSADGQNLT 121

Query: 108 -------TAHQWLFLYQLEQLLAERK-SADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
                      +  + ++   + +RK +ADP+TSY A L+  G   I +KVGEE  E  +
Sbjct: 122 QEQLTQAKKPIYGIIDEVYHTIMDRKLNADPQTSYVASLFKKGENAILKKVGEEATELVM 181

Query: 160 AATVHD 165
           A     
Sbjct: 182 ACKDAS 187



 Score = 51.5 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 13/35 (37%), Positives = 18/35 (51%)

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E+  EA+DL +H LV L   G+    V   L +R
Sbjct: 281 EEIVYEAADLCFHSLVALALHGIHPGRVKAELARR 315


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  176 bits (447), Expect = 4e-43,   Method: Composition-based stats.
 Identities = 64/209 (30%), Positives = 102/209 (48%), Gaps = 17/209 (8%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +        ++ DGL   +V     G  L L Y + E++ ++L +G+  + SR +  L
Sbjct: 191 VAKLVMANATSDRPDGLYTTLVTDER-GVALGLVYSSEESVAESLRTGRGVYQSRKRG-L 248

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE+SG+   +VS++ DCD+D L  +    G   CH  T +CFG     +  L +L++
Sbjct: 249 WYKGESSGDIQELVSMSFDCDSDCLQFVVRQKGRGFCHLATPTCFG----DYRGLSKLQK 304

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L  RK + P+ SYTA+L+ +  + +  K+ EE  E   A     +  +  EA+DL Y  
Sbjct: 305 TLQSRKESAPQGSYTARLF-NDAQLLRAKILEEATELCDAT---TKEHIAFEAADLFYFA 360

Query: 181 LVLLQDQGLDLTTVIENL------RKRHQ 203
           L      G+ L  V  NL       KR Q
Sbjct: 361 LTKCVAAGVSLEDVERNLDAKSIKVKRRQ 389


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  175 bits (444), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 62/191 (32%), Positives = 93/191 (48%), Gaps = 10/191 (5%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
             ++ DGL+P +V        L L Y + E++ + L++    + SR +  LW KG TSG+
Sbjct: 202 KSDRADGLIPTVVVDEHD-TALGLVYSSEESVGEALKTQTGVYQSRKRG-LWYKGATSGD 259

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADP 130
              +V I+ DCDND L  +    G  CH   S CFG        L +LE  L  RK + P
Sbjct: 260 TQELVRISLDCDNDALKFVVRQKGRFCHLEQSGCFG----DLKGLAKLESTLLSRKQSAP 315

Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190
             SYTA+L+ S  K +  K+ EE  E   A   +    +  EA+DL+Y  L      G+ 
Sbjct: 316 AGSYTARLF-SDEKLLRAKIMEEAEELCDA---NTPENVAFEAADLIYFALTKAVGAGVT 371

Query: 191 LTTVIENLRKR 201
           L  + ++L  +
Sbjct: 372 LADIEKSLDAK 382


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  170 bits (431), Expect = 2e-41,   Method: Composition-based stats.
 Identities = 59/207 (28%), Positives = 91/207 (43%), Gaps = 11/207 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L  ++TDGL    V  +     L L Y +P ++ K++ +G   + SR +  L
Sbjct: 193 IVDAFVAPLTSDRTDGLFATTVVSSACTASLGLVYSSPLSIRKSIVTGSAHYQSRNRG-L 251

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-----CHKGTSSCFGDTAHQWLFLY 116
           W KGE+SG    VVSI  DCD+D +         T     CH                L 
Sbjct: 252 WHKGESSGATQQVVSIRQDCDSDAIQFAVRQSRGTLASGFCHLENR---EGCFSSATGLA 308

Query: 117 QLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL 176
           +LE  L  R    P  SYTA+L+ +    +  K+ EE  E A A   +D+  +  EA+DL
Sbjct: 309 KLEATLKHRLQTAPAGSYTARLF-NDASLLGAKLREEAAELADA-NNNDKKHVAFEAADL 366

Query: 177 MYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +Y  L      G+ L  +  +L  + +
Sbjct: 367 IYFALTKCVSAGIGLEEIEASLDAKAK 393


>UniRef50_Q3B281 Phosphoribosyl-AMP cyclohydrolase n=43 Tax=cellular organisms
           RepID=HIS3_PELLD
          Length = 137

 Score =  170 bits (430), Expect = 3e-41,   Method: Composition-based stats.
 Identities = 50/136 (36%), Positives = 73/136 (53%), Gaps = 6/136 (4%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +       + ++   GL+P IVQ   +G+VLM+ +MN E+L+ TLE  K  ++SR++ +L
Sbjct: 7   IDNSFLDTVKFD-AKGLVPAIVQDHETGKVLMMAWMNRESLEMTLERKKACYWSRSRNKL 65

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGE+SGN  +V  I  DCD DTL++  + IG  CH G  SCF         L      
Sbjct: 66  WLKGESSGNMQDVYDILIDCDGDTLILKVSQIGGACHVGYHSCFYR-----RVLENGNME 120

Query: 122 LAERKSADPETSYTAK 137
           + +    DPE  Y  K
Sbjct: 121 ICDTLMFDPEEVYGKK 136


>UniRef50_B5VZW9 Phosphoribosyl-ATP diphosphatase n=2 Tax=Arthrospira
           RepID=B5VZW9_SPIMA
          Length = 200

 Score =  169 bits (429), Expect = 4e-41,   Method: Composition-based stats.
 Identities = 55/197 (27%), Positives = 93/197 (47%), Gaps = 17/197 (8%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+ + +Q  ++G VL LG MN EAL KTL + ++ +  +++  LW    
Sbjct: 21  IDKIRYD-DQGLVAIAIQDILNGGVLALGSMNREALQKTLATQQLWWVQQSQIELWHP-- 77

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
                + + SI+ D   + L+         C    +   G        L  L +++ +R+
Sbjct: 78  ----DIILESISYDYRGNFLVAGV----AYCPSELNGSGG------HTLAGLFRVICDRR 123

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
                 SYT +L+A G  +I +K+GEE  E  +A    +   + +E +DL YH LV L  
Sbjct: 124 DHPNSQSYTCQLFAGGDNKILKKIGEEAAEVVMACKDDEPQAIASEVADLFYHSLVALAY 183

Query: 187 QGLDLTTVIENLRKRHQ 203
             +DL  V E L  R Q
Sbjct: 184 HQVDLRKVYEQLEARRQ 200


>UniRef50_O59667 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Schizosaccharomyces
           RepID=HIS2_SCHPO
          Length = 417

 Score =  168 bits (425), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 61/203 (30%), Positives = 99/203 (48%), Gaps = 11/203 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L +      + ++ DGL   +V + + G  L L Y + E++ ++L++G   + SR +  L
Sbjct: 195 LADLILISANTDREDGLFSTLVVNEL-GIALGLVYSSKESVAESLKTGTGVYQSRKRG-L 252

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KG +SG   +++ I  DCD D L  +    G   CH  T  CFG  +        LE+
Sbjct: 253 WYKGASSGAVQHLIHIDVDCDEDCLRFVVYQTGKGFCHLDTLHCFGQASGLCQ----LEK 308

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL 180
            L +RK+  PE SYTA+L+ S  K +  K+ EE  E   A     +  +  E +DLMY  
Sbjct: 309 TLIDRKNNAPEGSYTARLF-SDPKLLRAKIMEEAEELCDAT---TKENVIWEMADLMYFA 364

Query: 181 LVLLQDQGLDLTTVIENLRKRHQ 203
           +      G+ L  +  +L  +H+
Sbjct: 365 ITRCVGSGVSLNDISRHLDLKHR 387


>UniRef50_A0YJX3 Phosphoribosyl-ATP
           pyrophosphohydrolase:phosphoribosyl-AMPcyclohydrolase
           n=1 Tax=Lyngbya sp. PCC 8106 RepID=A0YJX3_9CYAN
          Length = 198

 Score =  165 bits (419), Expect = 7e-40,   Method: Composition-based stats.
 Identities = 52/197 (26%), Positives = 88/197 (44%), Gaps = 13/197 (6%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ +    GL+P I+Q  + G VL L +M+ ++L KT E  +V     +   L +   
Sbjct: 15  IDKIRY-NEQGLIPAIIQEGLEGRVLTLVWMSSDSLHKTWEDQRVYNCQGSVVELGSDLL 73

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
            +G   +     P C +  +LV    I    ++               L ++ +++ +R+
Sbjct: 74  ITGWRYD-----PACQSLLILVECGSIAEPQNE-------FAQVSSNLLSEVFEVICDRR 121

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
               E SYT KL A G  +I +K+GEE  E  +A    D   + +E +DL YH LV +  
Sbjct: 122 DHPQEDSYTCKLLAGGDNKILKKIGEESAEVVMACKDDDTEAIASEVADLFYHTLVAIAY 181

Query: 187 QGLDLTTVIENLRKRHQ 203
              DL  V   L +R +
Sbjct: 182 HRADLRQVYRKLAERRR 198


>UniRef50_B3QLJ0 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_CHLP8
          Length = 137

 Score =  165 bits (417), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 49/134 (36%), Positives = 71/134 (52%), Gaps = 6/134 (4%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +     + ++   GL+P IVQ   +G+VLM+ +MN E+L  TLE  K  ++SR++ +LW 
Sbjct: 9   KSFLETVKFD-DRGLVPAIVQDHETGKVLMMAWMNLESLKMTLEKKKACYWSRSRNKLWL 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE+SGN  +V  I  DCD DTLL+  +  G  CH G  SCF         +      + 
Sbjct: 68  KGESSGNMQDVHDIMIDCDGDTLLLKVSQKGGACHVGYHSCFYRKTTDGEQME-----IC 122

Query: 124 ERKSADPETSYTAK 137
           +    DPE  Y  K
Sbjct: 123 DTLMFDPEEVYGKK 136


>UniRef50_A0LTT2 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Actinobacteridae
           RepID=HIS3_ACIC1
          Length = 142

 Score =  163 bits (414), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 4/135 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       L      GL P + Q   +GEVLM+G+M+ EAL +TL +G+ T++SR++Q  
Sbjct: 8   LDPAIAARLK-RDEHGLFPAVAQQYDTGEVLMVGWMDDEALHRTLTTGRCTYWSRSRQEY 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGETSG+   V S+A DCD DT+LV  + IG  CH G  +CF       +       +
Sbjct: 67  WVKGETSGHQQWVKSVALDCDGDTVLVKVDQIGAACHTGDRTCFDAGQLPAVVGEPPTPV 126

Query: 122 LAERKSADPETSYTA 136
            A  +      S TA
Sbjct: 127 GAGERQ---PASGTA 138


>UniRef50_Q3M244 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Bacteria RepID=HIS3_ANAVT
          Length = 116

 Score =  163 bits (414), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 41/108 (37%), Positives = 61/108 (56%), Gaps = 2/108 (1%)

Query: 6   QRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
              +L +   D L+P I Q    G VLM+ +MN E++ KTL +G+  ++SR++ +LW KG
Sbjct: 7   WFEKLKFNNQD-LIPAIAQDYRDGTVLMMAWMNSESIQKTLSTGEAHYWSRSRSQLWHKG 65

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQW 112
            TSG+   V  +  DCD DT+L+    IG   CH G  SCF +    +
Sbjct: 66  ATSGHIQKVKELFYDCDGDTILLKVEQIGDIACHTGARSCFFNAVPIY 113


>UniRef50_B3QE24 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Bacteria
           RepID=HIS3_RHOPT
          Length = 151

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 43/136 (31%), Positives = 72/136 (52%), Gaps = 2/136 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + E       ++   GL+ V+   A +G+VLM+ +MN EALD+T+++G+  ++SR+++RL
Sbjct: 17  IEEGVVLRPKFD-AHGLVTVVATDARTGDVLMVAFMNDEALDRTIQTGEAWYYSRSRKRL 75

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGETSG+   V+ +  DCD D + +  +   G  CH G  SCF     +      +  
Sbjct: 76  WKKGETSGHIQKVLEMRVDCDQDAVWIKVDQTGGAACHTGRHSCFYRRIDRGGDGAPVLI 135

Query: 121 LLAERKSADPETSYTA 136
                +  DP+  Y  
Sbjct: 136 ETDAERKFDPDKVYGK 151


>UniRef50_B3QU88 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_CHLT3
          Length = 140

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 48/136 (35%), Positives = 71/136 (52%), Gaps = 5/136 (3%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +  +    + ++K +GL+P I Q   +G+VLML YMN E+L+ TL+  K  ++SR++Q L
Sbjct: 7   IDVKLMDIVRFDK-NGLIPAITQDYETGKVLMLAYMNKESLEVTLKERKACYWSRSRQEL 65

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG TSGNF  V+ I+ DCD D +L+     G  CH G  SCF                
Sbjct: 66  WLKGATSGNFQEVMQISIDCDADAILLKVKQKGGACHVGYYSCFYRQVEN----DNSSLS 121

Query: 122 LAERKSADPETSYTAK 137
           + ++   D E  Y   
Sbjct: 122 ICDKLVFDAEEVYGKS 137


>UniRef50_B4CVB3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Chthoniobacter flavus
           Ellin428 RepID=B4CVB3_9BACT
          Length = 128

 Score =  163 bits (412), Expect = 5e-39,   Method: Composition-based stats.
 Identities = 52/131 (39%), Positives = 71/131 (54%), Gaps = 5/131 (3%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
              L +   DGL+P IVQ   +  VLM+ +MN  +L+ TL++G + ++SR++Q+ W KGE
Sbjct: 3   LPNLKY-TADGLIPAIVQDVKTKRVLMMAWMNATSLEATLQTGFMNYWSRSRQKFWLKGE 61

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           TSG+   VV  A DCD DTLL     IG  CH G  SCF                + E K
Sbjct: 62  TSGHTQKVVRWAVDCDADTLLFEVEQIGGACHTGFESCFFQAYSP----EGTPLEITEEK 117

Query: 127 SADPETSYTAK 137
             DPE +Y +K
Sbjct: 118 LFDPEKTYASK 128


>UniRef50_Q0RFX5 Phosphoribosyl-AMP cyclohydrolase n=21 Tax=Actinobacteridae
           RepID=HIS3_FRAAA
          Length = 132

 Score =  162 bits (411), Expect = 6e-39,   Method: Composition-based stats.
 Identities = 49/126 (38%), Positives = 65/126 (51%), Gaps = 1/126 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       L      GL P I Q   +GEVLMLG+M+ EAL +TL +G+ T++SR++   
Sbjct: 8   LDPAIASRLR-RNDAGLFPAIAQQHDTGEVLMLGWMDDEALHRTLTTGRATYWSRSRGEY 66

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG+TSG+   V S+A DCD D +LV  + IGP CH GT +CF                
Sbjct: 67  WVKGDTSGHQQWVRSVALDCDGDAVLVRVDQIGPACHTGTRNCFVADPLPTRVGDPGVTA 126

Query: 122 LAERKS 127
            A    
Sbjct: 127 DAGPAR 132


>UniRef50_Q03K83 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_STRTD
          Length = 112

 Score =  162 bits (410), Expect = 8e-39,   Method: Composition-based stats.
 Identities = 47/106 (44%), Positives = 65/106 (61%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +LD++K  GL+PVIV    +G+VLML YMN  +   TLE+ ++ ++SR++  LW KG TS
Sbjct: 5   KLDFDKQGGLVPVIVTDYKTGQVLMLAYMNEVSYQLTLETKQMHYWSRSRNELWHKGATS 64

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           G+F +V SI  DCD DTLL+     G  CH G  SCF    +    
Sbjct: 65  GHFQHVKSIKTDCDWDTLLIAVEQEGAACHTGAYSCFFTDIYDDNQ 110


>UniRef50_C4XTP1 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Bacteria
           RepID=C4XTP1_DESMR
          Length = 124

 Score =  162 bits (409), Expect = 9e-39,   Method: Composition-based stats.
 Identities = 58/129 (44%), Positives = 75/129 (58%), Gaps = 7/129 (5%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
            +  D+ K  GL+P I Q A SGEVLML YMN EA DKTL +G+V +FSR++Q++W KG 
Sbjct: 1   MKRPDFAKCGGLVPAIAQEACSGEVLMLAYMNEEAYDKTLATGEVHYFSRSRQKIWHKGG 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
           TSG+   V S+  DCD DT+LVL   I G  CH+G  SCF         +    +     
Sbjct: 61  TSGHVQKVHSVRLDCDADTILVLVEQIGGAACHEGYKSCFF------TEITSDGERTCSP 114

Query: 126 KSADPETSY 134
           K  DP+  Y
Sbjct: 115 KVFDPKEVY 123


>UniRef50_B8J3P0 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Proteobacteria
           RepID=B8J3P0_DESDA
          Length = 137

 Score =  161 bits (407), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 69/129 (53%), Gaps = 7/129 (5%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
                + + GL+P I Q   SGEVLML YMN EA  KTLE+G+  ++SR+++++W KG T
Sbjct: 14  EAFTPDFSKGLLPAIAQDHASGEVLMLAYMNEEAWRKTLETGQAHYWSRSREKIWHKGGT 73

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERK 126
           SG+   V+++  DCD+DT+L+  + + G  CH G  +CF                     
Sbjct: 74  SGHIQKVLAVRLDCDSDTVLLFVDQVGGAACHTGRRTCFYRE------WKDGAVSECAPM 127

Query: 127 SADPETSYT 135
             DP+  Y 
Sbjct: 128 VFDPQKVYG 136


>UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]
           imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales
           RepID=C4Z0A8_EUBE2
          Length = 362

 Score =  160 bits (406), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 51/113 (45%), Positives = 71/113 (62%), Gaps = 1/113 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             +   ++L  +  +GL+PV+VQ  V+ EVLML YMN EA +KTLE+G +T++SR++Q L
Sbjct: 251 KADISFKDLKLD-ANGLIPVVVQDYVNDEVLMLAYMNEEAYNKTLETGIMTYYSRSRQEL 309

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLF 114
           W KG TSG+F  V S+  DCDNDT+L     +G  CH G  +CF      W  
Sbjct: 310 WVKGLTSGHFQYVGSLDIDCDNDTILAKVRQVGAACHTGNRTCFYRNIKTWNR 362


>UniRef50_Q2SLC2 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Gammaproteobacteria
           RepID=Q2SLC2_HAHCH
          Length = 139

 Score =  160 bits (405), Expect = 2e-38,   Method: Composition-based stats.
 Identities = 47/119 (39%), Positives = 70/119 (58%), Gaps = 1/119 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                EL +    GL+PVI Q A +  +LM  +MN EAL+KT+ + ++T++SR++QRLW 
Sbjct: 21  PDVIAELAF-NEQGLIPVITQDASTKSILMFAWMNVEALEKTISTRRMTYWSRSRQRLWV 79

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGETSG+   +VS++ DCD D +L L +  G  CH G  +CF         L  +E+  
Sbjct: 80  KGETSGHVQRLVSMSFDCDGDAILCLVDQQGAACHTGRQTCFYLQVEPDKQLVWVERGC 138


>UniRef50_Q134L8 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_RHOPS
          Length = 147

 Score =  159 bits (403), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 46/133 (34%), Positives = 71/133 (53%), Gaps = 1/133 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + E       ++   GL+  +   A SGEVLM+ +MN EAL+KT++SG+  ++SR+++RL
Sbjct: 14  IEEGIALRPKFDAA-GLVTCVTTDARSGEVLMVAHMNAEALEKTVQSGEAWYYSRSRKRL 72

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGE+SG+   V+ I  DCD D + +     G  CH G  SCF     +      L  +
Sbjct: 73  WKKGESSGHVQRVLEIRVDCDQDAVWLRVEQAGAACHTGRQSCFYRRIDRDGSGAPLLTM 132

Query: 122 LAERKSADPETSY 134
           +   +  DP   Y
Sbjct: 133 VDADRLFDPAKIY 145


>UniRef50_Q4JW51 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Bacteria
           RepID=HIS3_CORJK
          Length = 127

 Score =  159 bits (403), Expect = 5e-38,   Method: Composition-based stats.
 Identities = 43/105 (40%), Positives = 60/105 (57%), Gaps = 1/105 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L       + +   DGL+P IVQ   +G+VLM+ +MN  AL  TL + K T++SR++Q  
Sbjct: 19  LDPAIAERVRF-NADGLVPAIVQDITNGDVLMMAWMNDHALAHTLATKKGTYWSRSRQSY 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           W KGETSG+   V  +  DCD DT+L+     G  CH G  +CF 
Sbjct: 78  WIKGETSGHTQRVEEVRLDCDGDTVLLKIEQTGAACHTGNRTCFD 122


>UniRef50_D0NCL3 Histidine biosynthesis trifunctional protein, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0NCL3_PHYIN
          Length = 477

 Score =  159 bits (402), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 10/198 (5%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
              + L  ++ D L   +V    +G  L L Y + E++   + SG+  ++SR++  LW K
Sbjct: 244 AFVKCLRTDRPDSLFTTVVAD-EAGVALGLVYSSAESIIAAVSSGRGVYYSRSRGGLWKK 302

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE+SGN   ++ I  DCD+D L    N  G   CH  T +C+G        L  LE +L 
Sbjct: 303 GESSGNAQKLIQIDMDCDSDALRFTVNQTGAGFCHLDTRTCWGHD----GGLRALESMLF 358

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
            R    P  SYT +L+    + +  K+     E    A      ++  EA+D+MY  +V 
Sbjct: 359 SRHENAPAESYTKRLF-DDAELLRNKLV---EEAQELAEAESVPDVAGEAADVMYFAMVR 414

Query: 184 LQDQGLDLTTVIENLRKR 201
               G  L+ V   L KR
Sbjct: 415 CVAAGCKLSDVERMLDKR 432


>UniRef50_D2R0U5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R0U5_9PLAN
          Length = 310

 Score =  159 bits (402), Expect = 6e-38,   Method: Composition-based stats.
 Identities = 40/125 (32%), Positives = 64/125 (51%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
                L+P I Q   +GEVLM+ +MN E+  +T+ +G+  ++SR++ +LW KGE SG+  
Sbjct: 176 RGEQRLLPAIAQDHATGEVLMMAWMNEESFAETMATGRAVYYSRSRGKLWRKGEESGHMQ 235

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            V  +  DCD DT+L+  + +G  CH+G  SCF             E+L+          
Sbjct: 236 TVHGVYVDCDADTILLKVSQVGAACHEGFRSCFFRQVTPLGLTVVAERLVEPASVYKNPK 295

Query: 133 SYTAK 137
           S+   
Sbjct: 296 SHAKS 300


>UniRef50_Q702A1 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=uncultured
           crenarchaeote RepID=Q702A1_9CREN
          Length = 115

 Score =  158 bits (399), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 42/111 (37%), Positives = 67/111 (60%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   +LD+ K DGL+PV+VQ   + ++LML Y N  A++ T+++G   F+S ++ +L
Sbjct: 5   IQDEFIDKLDFVKRDGLIPVVVQDIKTKDILMLAYANRVAIENTVKTGNAWFWSVSRNKL 64

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQW 112
           W KGE SGN   V  I  DCD D++L L +   P CH G  +CF +  +  
Sbjct: 65  WMKGEESGNVQEVKDILVDCDQDSVLYLVDSKNPACHTGNRTCFHNRLYPN 115


>UniRef50_A4GIE4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria
           RepID=A4GIE4_9BACT
          Length = 132

 Score =  158 bits (399), Expect = 1e-37,   Method: Composition-based stats.
 Identities = 42/118 (35%), Positives = 68/118 (57%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+P I Q   +GEVLM+ +MN  +L +TL +G++ ++SR+++ LW KG+TSG+   +
Sbjct: 15  ADGLIPAIAQQFDTGEVLMMAWMNKNSLAETLATGRICYWSRSRRSLWRKGDTSGHIQKL 74

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
           + +  DCD D++LVL +  G  CH+GT SCF         + + E     +       
Sbjct: 75  IELRYDCDADSILVLVDQSGAACHEGTRSCFTRRLEIDGSISEAETAYPTKIDESARQ 132


>UniRef50_A8LK58 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Alphaproteobacteria
           RepID=HIS3_DINSH
          Length = 119

 Score =  157 bits (397), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 45/115 (39%), Positives = 68/115 (59%), Gaps = 1/115 (0%)

Query: 8   RELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGET 67
             L ++   GL+P I Q A SGEVLM+ +MN EA+ +TLE+G+VT++SR++Q  W KGE+
Sbjct: 6   ASLRYD-DQGLIPAIAQDAASGEVLMMAWMNAEAVARTLETGRVTYWSRSRQAFWIKGES 64

Query: 68  SGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           SG+   +V +  DCD D LL+     GP CH    +CF         +  +  ++
Sbjct: 65  SGHVQTLVEMRVDCDRDCLLLQVRQEGPACHTNRRTCFYTAIRDGAEVELMAPMV 119


>UniRef50_Q39K84 Phosphoribosyl-AMP cyclohydrolase n=75 Tax=Proteobacteria
           RepID=HIS3_BURS3
          Length = 138

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 47/132 (35%), Positives = 72/132 (54%), Gaps = 4/132 (3%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                ++ W+  +GL+PVI Q A + +VLM  +MN EAL KT+E+ +  ++SR+++RLW 
Sbjct: 9   PAWLDKVRWD-DNGLVPVIAQEASTNDVLMFAWMNREALAKTIETQRAVYYSRSRKRLWF 67

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPI-GPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+  +V  +  DCD D +L+    + G  CH G  SCF         +   + + 
Sbjct: 68  KGEESGHVQHVHEVRLDCDEDVVLLKVEQVSGIACHTGRHSCFFQKFE--GTVDNGDWVA 125

Query: 123 AERKSADPETSY 134
            E    DPE  Y
Sbjct: 126 VEPVLKDPEHIY 137


>UniRef50_D1SGQ9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Micromonospora aurantiaca
           ATCC 27029 RepID=D1SGQ9_9ACTO
          Length = 444

 Score =  156 bits (395), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 45/117 (38%), Positives = 62/117 (52%), Gaps = 1/117 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L      +L     DGL+  +V+   SGEVLM+ +M+ EAL +TL +G+ T++SR++   
Sbjct: 329 LDPAVAAKLR-RTPDGLVAAVVRAHDSGEVLMVAWMDDEALHRTLTTGRATYWSRSRGEY 387

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQL 118
           W KG TSGN   V S+A DCD D LLV    +G  CH G  +CF             
Sbjct: 388 WVKGATSGNHQYVRSVALDCDGDALLVSVEQVGAACHTGQRTCFFTELPVSTPEATP 444


>UniRef50_C6XNB8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hirschia baltica ATCC
           49814 RepID=C6XNB8_HIRBI
          Length = 139

 Score =  156 bits (394), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 59/108 (54%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
            +DGL+  I Q   S EVLML +MN +AL  T+E+G+  ++SR++ +LW KG+TSG +  
Sbjct: 30  NSDGLVAAIAQDVSSNEVLMLAWMNEDALKLTIETGRAVYWSRSRNQLWRKGDTSGAYQY 89

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           V SI  DCD D +L+        CH G  SCF         L   E  
Sbjct: 90  VESIHTDCDQDAILLKVRQTDGACHTGRVSCFYRQITDLSTLNPTEDK 137


>UniRef50_Q31J60 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Proteobacteria
           RepID=HIS3_THICR
          Length = 147

 Score =  156 bits (394), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 44/122 (36%), Positives = 68/122 (55%), Gaps = 1/122 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E  ++++ ++  +GL+P I Q   S EVLM+ +MN  AL +TLE+G+V ++SR++Q  W 
Sbjct: 22  EAVKKQVKYD-DNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR 80

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGE SG    +  +  DCD D +L+L +  GP CH G  SCF    H          ++ 
Sbjct: 81  KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPIID 140

Query: 124 ER 125
             
Sbjct: 141 PE 142


>UniRef50_C8PI34 Phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP
           cyclohydrolase n=1 Tax=Campylobacter gracilis RM3268
           RepID=C8PI34_9PROT
          Length = 336

 Score =  156 bits (394), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 54/141 (38%), Positives = 67/141 (47%), Gaps = 1/141 (0%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           ++DW+K  GL+P IVQ A  G VLML YMN EAL  TL +G   +FSR+K R+W KGE S
Sbjct: 2   KVDWQKLGGLLPAIVQDAGDGAVLMLAYMNEEALSLTLRTGYAHYFSRSKGRIWKKGEES 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           G+   V S   DCDND LL+     G   CH G  SCF            +         
Sbjct: 62  GHVQLVKSAFLDCDNDALLLKIEQCGGSACHTGARSCFFKEISLQKCGENVGSSSTCGAI 121

Query: 128 ADPETSYTAKLYASGTKRIAQ 148
              E   T  L    ++    
Sbjct: 122 NFAEHGSTTSLAQKNSENSRA 142



 Score = 56.5 bits (135), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 28/132 (21%), Positives = 48/132 (36%), Gaps = 24/132 (18%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA-DPETSYTAKLYASGTKRIAQKVG 151
                +    +        +  L ++  +  +RK   +P  SY A LYA G     +K+ 
Sbjct: 194 DAAAQNSTLENSAEKG--PYSVLDEIYHICLDRKLNGEPALSYVASLYAKGENAYLKKIA 251

Query: 152 EEGVETALAATVHDRFELTNEAS--------------DLMYH-------LLVLLQDQGLD 190
           EE  E ALA     R EL  + +              D++Y        LL+ L    + 
Sbjct: 252 EEACEFALACKDLSRSELYADVAREGFGEHRAGEPRYDVIYEGADLLFHLLLALAAHNIH 311

Query: 191 LTTVIENLRKRH 202
              +++ L +R 
Sbjct: 312 PDALLDELARRQ 323


>UniRef50_B7RXC3 Phosphoribosyl-AMP cyclohydrolase domain protein n=1 Tax=marine
           gamma proteobacterium HTCC2148 RepID=B7RXC3_9GAMM
          Length = 151

 Score =  156 bits (394), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 45/113 (39%), Positives = 62/113 (54%), Gaps = 1/113 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               +L +    GL+P + Q A +G+VLML +MN  A++KTLE+G++T+FSR++  LW K
Sbjct: 33  DVIEQLAY-NDKGLIPAVAQDAQTGKVLMLAWMNRTAVEKTLETGRMTYFSRSRNELWVK 91

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQ 117
           G  SGN   +V    DCD D LL      G  CH G  SCF   A+       
Sbjct: 92  GLASGNHQQLVEARIDCDGDALLCRVIQEGSACHTGRHSCFYLKANPANQQVY 144


>UniRef50_B9QYY7 Phosphoribosyl-AMP cyclohydrolase domain protein n=2 Tax=Bacteria
           RepID=B9QYY7_9RHOB
          Length = 159

 Score =  155 bits (393), Expect = 6e-37,   Method: Composition-based stats.
 Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 3/128 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            +++ DGL+  +V    + EVLM+GYMN EAL +T+E+G+  ++SR+++  W KGETSG 
Sbjct: 32  KFDQ-DGLIAAVVIDFKTSEVLMVGYMNEEALKRTIETGEAWYWSRSRKGFWKKGETSGQ 90

Query: 71  FLNVVSIAPDCDNDTLLVL--ANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D L+V       G TCH G  SCF                + + K  
Sbjct: 91  IQKVQEILTDCDQDALVVKVTVEGNGATCHVGYRSCFFRKVVNTSDGTVRLANVEKEKVY 150

Query: 129 DPETSYTA 136
           DP+  Y  
Sbjct: 151 DPKKVYGK 158


>UniRef50_Q2S3T1 Phosphoribosyl-AMP cyclohydrolase n=26 Tax=Bacteria
           RepID=HIS3_SALRD
          Length = 127

 Score =  155 bits (393), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 48/133 (36%), Positives = 69/133 (51%), Gaps = 7/133 (5%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           +++      D+   DGL+P IVQ A + +VLM+ YM  E L +TL++G++ ++SR++Q  
Sbjct: 1   MSDPLLDAADF-TDDGLIPAIVQDAETDQVLMMAYMTAETLQETLDTGRMVYWSRSRQER 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KG+TSG+   V     DCD DTLL   +  G  CH G  SCF   A            
Sbjct: 60  WVKGQTSGHTQTVEEARLDCDGDTLLFRVHQEGGACHTGFRSCFHRRAAD------DGWT 113

Query: 122 LAERKSADPETSY 134
               K  DP+  Y
Sbjct: 114 TDGEKVFDPDAVY 126


>UniRef50_Q0FGM5 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Rhodobacterales bacterium
           HTCC2255 RepID=Q0FGM5_9RHOB
          Length = 120

 Score =  155 bits (393), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 42/107 (39%), Positives = 63/107 (58%), Gaps = 1/107 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +     L ++  +GL+P +VQ   + EVLM+ +MN  +L+KT E+   TF+SR+++ L
Sbjct: 1   MAKFDISSLKFD-DNGLIPAVVQDTTTLEVLMVAWMNKLSLEKTFETNLATFWSRSRKCL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           W KG TSGN   V  +  DCD D +L+L  P GP CH    +CF   
Sbjct: 60  WVKGLTSGNTQKVDKVRFDCDRDCILLLVTPEGPACHTNRRNCFYTE 106


>UniRef50_Q1GGT9 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Proteobacteria
           RepID=HIS3_SILST
          Length = 129

 Score =  155 bits (392), Expect = 9e-37,   Method: Composition-based stats.
 Identities = 43/107 (40%), Positives = 61/107 (57%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
              GL+P I Q   SGE+LM+ +MN E++ KTLE+G+VT++SR++Q  W KGE+SG+   
Sbjct: 21  NEAGLVPCIAQDVESGEILMMAWMNAESVAKTLETGRVTYWSRSRQSFWIKGESSGHVQE 80

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           +V +  DCD D LL +    GP CH    SCF            +  
Sbjct: 81  LVELRVDCDRDALLAMVRQTGPACHTNRRSCFYTAIRDGEEHEIMTP 127


>UniRef50_Q01ZT9 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=cellular organisms
           RepID=HIS3_SOLUE
          Length = 126

 Score =  155 bits (391), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 57/130 (43%), Positives = 79/130 (60%), Gaps = 7/130 (5%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
            LD+ K+DGL+  ++Q   SG VLM+GYMN EA +KT+E+G  TF+SR++++LW KGE+S
Sbjct: 2   NLDFAKSDGLVTAVIQDHASGRVLMVGYMNQEAFNKTVETGFATFWSRSRKKLWLKGESS 61

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKS 127
           G+ L V  I+ DCD D +LV     GP  CH+G  SCF         L   E  +A+  +
Sbjct: 62  GHRLVVKEISTDCDLDAVLVKVEAQGPGVCHEGYESCFFRR------LDAGEWKVADNPT 115

Query: 128 ADPETSYTAK 137
            DP   Y  K
Sbjct: 116 YDPGAVYGGK 125


>UniRef50_O26347 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_METTH
          Length = 138

 Score =  155 bits (391), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 4/122 (3%)

Query: 14  KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLN 73
             + L+  + Q   +GEVLM+ YMN EAL +TLE+G   ++S ++ +LW KGE+SG+   
Sbjct: 19  NGEDLIIAVAQDHETGEVLMVAYMNREALRRTLETGTAHYWSTSRGKLWLKGESSGHVQR 78

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
           V  +  DCD D +++     G  CH G  SCF  +        + + +    K  DPE  
Sbjct: 79  VKDVLVDCDGDAVVLKVEQEGGACHTGYRSCFYRSIDGDELKVREDAV----KVFDPEEI 134

Query: 134 YT 135
           Y 
Sbjct: 135 YG 136


>UniRef50_D1CF76 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Thermobaculum terrenum
           ATCC BAA-798 RepID=D1CF76_THET1
          Length = 300

 Score =  155 bits (391), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 27/209 (12%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                L ++   GL+PV+VQ A + +VL++ +MN EAL++TL +G V F+SR+++++W K
Sbjct: 9   NLVDMLQYD-EHGLLPVVVQDAATLKVLLVAFMNREALERTLSTGLVHFWSRSRKKIWLK 67

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GETSG  L+V  + P+C+ ++LL+L +   P  CH G  SCF         +     L  
Sbjct: 68  GETSGRTLHVRELRPNCELNSLLILVDQRLPGACHTGHFSCFYRRLEDGELVEIEPPLFD 127

Query: 124 ER-----------------KSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT---- 162
                              +    ++S T+K+          ++ EE  E          
Sbjct: 128 PEDVYSDLSVLLGAYDWLSRQPTIDSSSTSKILHGAGPDPWARLLEEWQELLGVLEGTHV 187

Query: 163 -VHDRFELTNEASDLMYH---LLVLLQDQ 187
                 +   EA  ++Y      VLL D+
Sbjct: 188 HKGYYEDAKLEAYQVLYWTCLCYVLLDDR 216


>UniRef50_Q46WL9 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Bacteria
           RepID=HIS3_RALEJ
          Length = 135

 Score =  154 bits (390), Expect = 1e-36,   Method: Composition-based stats.
 Identities = 49/137 (35%), Positives = 72/137 (52%), Gaps = 4/137 (2%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + ++   ++ W+  +GL+PVIVQ   + +VLM  +MN +AL KT E G+  F+SR+++RL
Sbjct: 1   MAKKWLNKVKWD-DNGLVPVIVQEVGTNDVLMFAFMNRDALQKTAELGEAVFWSRSRKRL 59

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           W KGE SG+   V  +  DCD D +L+         CH G  SCF             + 
Sbjct: 60  WHKGEESGHVQKVHEMRLDCDEDVVLLKVTQVDNIACHTGRHSCFFQKFEGDAESGDWQT 119

Query: 121 LLAERKSADPETSYTAK 137
           +    K  DP   YTAK
Sbjct: 120 VEPVLK--DPSQIYTAK 134


>UniRef50_B6R0N1 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R0N1_9RHOB
          Length = 156

 Score =  154 bits (389), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 45/129 (34%), Positives = 66/129 (51%), Gaps = 3/129 (2%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+   V    SGE+LM+GYMN E+L +T+E+G+  ++SR++Q  W KG TSG 
Sbjct: 28  KFD-ENGLIAAAVTDFDSGELLMVGYMNSESLRRTIETGEAWYWSRSRQEYWKKGGTSGQ 86

Query: 71  FLNVVSIAPDCDNDTLL--VLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V+ I  DCD D +   V  +  G TCH G  SCF    +         +        
Sbjct: 87  VQEVIEIRTDCDQDAIWLRVKVHGNGATCHVGYRSCFFRKVNSNETGDVWLEKTEVAPVY 146

Query: 129 DPETSYTAK 137
           DP+  Y  K
Sbjct: 147 DPQEVYGKK 155


>UniRef50_B9M8U6 Phosphoribosyl-AMP cyclohydrolase n=7 Tax=cellular organisms
           RepID=HIS3_GEOSF
          Length = 126

 Score =  154 bits (389), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 48/129 (37%), Positives = 70/129 (54%), Gaps = 7/129 (5%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++D++K  GL+P ++Q   SGEVLM+ +M+ + LD TL+ GK  FFSRT+ + W KGE
Sbjct: 1   MIKIDFDKMGGLIPAVIQDYQSGEVLMVAFMDQKTLDLTLKDGKTWFFSRTRNKYWMKGE 60

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAER 125
            SGN   V+ +  DCD DT+++     GP  CH G  SCF       +     + +    
Sbjct: 61  ESGNTQEVMEVLTDCDADTVVIKVKQNGPAACHTGNRSCFY------VKWEDGQWVEHSN 114

Query: 126 KSADPETSY 134
              DP   Y
Sbjct: 115 PLFDPNEVY 123


>UniRef50_Q18DH0 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Euryarchaeota
           RepID=HIS3_HALWD
          Length = 132

 Score =  154 bits (389), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 54/131 (41%), Positives = 75/131 (57%), Gaps = 10/131 (7%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ +  +DGL+P I Q A SGEVLML Y++P AL +T E+G+  ++SR+++ LW 
Sbjct: 11  DDAEIEIRF-NSDGLVPAIAQDADSGEVLMLAYVSPTALKRTRETGQAHYYSRSREELWK 69

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           KGETSG+  ++  I  DCD DT+L L    G  CH G  SCF  T         L+    
Sbjct: 70  KGETSGHTQHIREIRADCDADTILYLVEQTGGACHTGHQSCFYRT---------LDGTEV 120

Query: 124 ERKSADPETSY 134
             +  DPET Y
Sbjct: 121 TERVFDPETVY 131


>UniRef50_B7GQS6 Phosphoribosyl-AMP cyclohydrolase n=55 Tax=Bacteria
           RepID=HIS3_BIFLI
          Length = 136

 Score =  153 bits (388), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 46/104 (44%), Positives = 64/104 (61%), Gaps = 1/104 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L  +    L      GL+  ++Q   + EVLM+GYMN EAL +TL +G+VTF+SR++Q  
Sbjct: 12  LDPRIAARLK-RDVKGLVAAVIQQYDTHEVLMVGYMNDEALRRTLTTGRVTFWSRSRQEY 70

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
           W KG+TSG+   V  ++ DCD D LLV  + +G  CH G  SCF
Sbjct: 71  WRKGDTSGHVQYVKGVSLDCDGDALLVEVDQVGAACHTGKRSCF 114


>UniRef50_B0REU6 Phosphoribosyl-AMP cyclohydrolase n=11 Tax=Actinobacteria (class)
           RepID=HIS3_CLAMS
          Length = 138

 Score =  152 bits (384), Expect = 7e-36,   Method: Composition-based stats.
 Identities = 46/107 (42%), Positives = 65/107 (60%), Gaps = 1/107 (0%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
            +       +   DGL+P ++Q   + EVLMLGYM+ EAL +TL +G+VTF+SR++   W
Sbjct: 16  VDGILARASF-ADDGLLPAVIQQHDTREVLMLGYMDREALRRTLTTGRVTFWSRSRSEYW 74

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
            KG+TSG+   V   A DCD DT+LV  + +G  CH GT +CF    
Sbjct: 75  RKGDTSGHGQYVRDAALDCDGDTVLVQVDQVGVACHTGTRTCFDADH 121


>UniRef50_Q5FPD9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Acetobacteraceae
           RepID=HIS3_GLUOX
          Length = 156

 Score =  152 bits (384), Expect = 8e-36,   Method: Composition-based stats.
 Identities = 40/124 (32%), Positives = 68/124 (54%), Gaps = 2/124 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +    ++ ++  +GL+  + Q A  G VLML +MN +AL +TL +G+V ++SR++Q+L
Sbjct: 30  IVDDIIAQVKFD-ANGLISALAQ-APDGVVLMLAWMNADALRETLLTGRVCYWSRSRQKL 87

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
           W KGETSG    ++    DCD D +L++ +  G  CH G  SCF             +  
Sbjct: 88  WRKGETSGQQQKLIEARLDCDMDAVLMIVDQTGVACHTGRRSCFYHGVTPDGLRDTSQPE 147

Query: 122 LAER 125
           ++  
Sbjct: 148 ISAE 151


>UniRef50_UPI000050F746 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Brevibacterium linens BL2
           RepID=UPI000050F746
          Length = 123

 Score =  151 bits (382), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 48/111 (43%), Positives = 67/111 (60%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T +  REL    +DGL+PVIVQ   + EVLM+ +M+ EA+++TL +G   ++SR++Q  W
Sbjct: 13  TPENWRELITLNSDGLIPVIVQEVNTREVLMMAWMDVEAIERTLSTGAAVYWSRSRQEYW 72

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
            KGETSGN   V S++ DCD D LL+     GP CH  T +CF        
Sbjct: 73  VKGETSGNTQKVASLSLDCDADALLMEVEQTGPACHTLTPTCFTGRTISAN 123


>UniRef50_Q1QWC3 Phosphoribosyl-AMP cyclohydrolase n=14 Tax=Proteobacteria
           RepID=HIS3_CHRSD
          Length = 146

 Score =  151 bits (381), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 49/135 (36%), Positives = 69/135 (51%), Gaps = 7/135 (5%)

Query: 3   TEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLW 62
           T        W    GL+P I Q   SGEVLM+ +MN  AL++TL +G+V ++SR++ + W
Sbjct: 19  TRDLLDAARW-NDAGLIPAIAQQHDSGEVLMMAWMNRAALEETLATGRVCYWSRSRGKPW 77

Query: 63  TKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
            KGE+SG    +V+   DCD DTLL+  +  GP CH G  SCF       + L      +
Sbjct: 78  RKGESSGQVQQLVTAHLDCDGDTLLLGVDQQGPACHTGRRSCFY------VALGADTAHV 131

Query: 123 AERKSADPETSYTAK 137
                 DP   Y  +
Sbjct: 132 DSAPLVDPHELYGER 146


>UniRef50_B4RV64 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Alteromonas macleodii
           'Deep ecotype' RepID=B4RV64_ALTMD
          Length = 133

 Score =  151 bits (381), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 46/110 (41%), Positives = 68/110 (61%), Gaps = 1/110 (0%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           ++   EL+++  DGL+PVI Q   S +VLM  +M+ E+LD+TL +GK+ ++SR++Q LW 
Sbjct: 20  DKVIAELNFD-ADGLIPVIAQDEKSMKVLMFAWMSKESLDETLRTGKMCYWSRSRQGLWR 78

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWL 113
           KG +SG+   V SIA DCD D LL   + +G  CH    SCF     +  
Sbjct: 79  KGSSSGHSQTVKSIAADCDGDVLLAEVSQVGFACHTRRHSCFYLRFWEDK 128


>UniRef50_A5UMF9 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Methanobacteriaceae
           RepID=HIS3_METS3
          Length = 132

 Score =  151 bits (381), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 40/131 (30%), Positives = 66/131 (50%), Gaps = 5/131 (3%)

Query: 9   ELDWE---KTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           E+++        ++  I Q   +G++LM+  MN +AL KT+E+GK  ++S ++   W KG
Sbjct: 2   EINFRHEINGQKVITAIAQDWKTGQILMVANMNKDALQKTIETGKAHYWSTSRNSQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE- 124
           E+SG+   V  I  DCD D +++     G  CH+G  SCF    +        E+ L   
Sbjct: 62  ESSGHTQEVKEILVDCDMDAVVLKVKQNGAACHEGYFSCFFRKLNTKNIENFNEEDLETI 121

Query: 125 -RKSADPETSY 134
             K  +P+  Y
Sbjct: 122 LEKVFNPDDVY 132


>UniRef50_A1TL07 Phosphoribosyl-AMP cyclohydrolase n=124 Tax=Bacteria
           RepID=HIS3_ACIAC
          Length = 141

 Score =  150 bits (380), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 53/134 (39%), Positives = 69/134 (51%), Gaps = 11/134 (8%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               E+ W+   GL+PVI Q A +G+VLM  +MN EAL KT E G+  +FSR++ RLW K
Sbjct: 14  SWLDEVKWD-AQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYFSRSRGRLWFK 72

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPI----GPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           GE SG+   V  I  DCDND +L+    +    G  CH G  SCF         L     
Sbjct: 73  GEESGHVQTVHEIRLDCDNDVVLLKVTQLGHEPGIACHTGRHSCFFS------VLKDGAW 126

Query: 121 LLAERKSADPETSY 134
              +    DPE+ Y
Sbjct: 127 QAVDPVLKDPESIY 140


>UniRef50_UPI000185C2AA phosphoribosyl-AMP cyclohydrolase n=1 Tax=Corynebacterium
           amycolatum SK46 RepID=UPI000185C2AA
          Length = 132

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 41/106 (38%), Positives = 59/106 (55%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
                 +     DGL+P IVQ   +G VLM+ +M+  AL  T+ + + T++SR++   W 
Sbjct: 23  PADIANIAKFNADGLIPAIVQEESTGRVLMMAWMDSHALAYTIATKRGTYWSRSRSEYWI 82

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTA 109
           KG TSG+F  V S+A DCD DT+L+     G  CH G+ SCF    
Sbjct: 83  KGLTSGHFQTVTSLALDCDGDTVLMQVVQDGAACHTGSHSCFDVHP 128


>UniRef50_Q4ZZG6 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=cellular organisms
           RepID=HIS3_PSEU2
          Length = 130

 Score =  149 bits (377), Expect = 5e-35,   Method: Composition-based stats.
 Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 8/132 (6%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +    E+ W  +DGL+P I Q   +G VLM+ +MN EAL  T    +  ++SR++ +LW 
Sbjct: 2   KDWLDEIHW-NSDGLVPAIAQDHKTGRVLMMAWMNREALSLTAAENRAIYWSRSRGKLWR 60

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           KGE SG+   +  +  DCD D ++++   IG   CH G  SCF           +     
Sbjct: 61  KGEESGHVQKLHELRLDCDADVIILMVEQIGGIACHTGRESCFYRVY------EKSGWKT 114

Query: 123 AERKSADPETSY 134
            +    DP+  Y
Sbjct: 115 VDPVLKDPDAIY 126


>UniRef50_A7GMV1 Phosphoribosyl-AMP cyclohydrolase n=25 Tax=Bacteria
           RepID=HIS3_BACCN
          Length = 101

 Score =  149 bits (376), Expect = 6e-35,   Method: Composition-based stats.
 Identities = 43/94 (45%), Positives = 61/94 (64%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           + GL+P IV +  + EVLML YMN EA +KTL++ K  F+SR++Q LW KG TSG+  +V
Sbjct: 6   SKGLLPAIVINEETKEVLMLAYMNEEAYEKTLKTKKTWFYSRSRQTLWNKGATSGHVQHV 65

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            S+  DCD D +++  N +G  CH G  +CF   
Sbjct: 66  KSLYLDCDQDAIVITVNQVGVACHTGEKTCFHHK 99


>UniRef50_C3MB44 Phosphoribosyl-AMP cyclohydrolase n=8 Tax=Rhizobiales
           RepID=HIS3_RHISN
          Length = 152

 Score =  148 bits (375), Expect = 8e-35,   Method: Composition-based stats.
 Identities = 46/129 (35%), Positives = 64/129 (49%), Gaps = 4/129 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  A  GE+LM+ +MN EAL  T+E+G   ++SR++  LW KGE+SGN
Sbjct: 24  RFD-EKGLVTAVVTDARDGELLMVAHMNAEALALTIETGIAHYYSRSRNSLWKKGESSGN 82

Query: 71  FLNVVSIAPDCDNDTLLVLANPIG--PTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
              V  I  DCD D + +     G   TCH G  SCF  T        ++      R   
Sbjct: 83  TQAVQEIRTDCDQDAIWLKVTVAGHDATCHTGRRSCFYRTVGVENGKARVTITDEHR-HF 141

Query: 129 DPETSYTAK 137
           DP   Y  K
Sbjct: 142 DPAQIYAEK 150


>UniRef50_Q111X7 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=root RepID=Q111X7_TRIEI
          Length = 161

 Score =  148 bits (375), Expect = 9e-35,   Method: Composition-based stats.
 Identities = 48/140 (34%), Positives = 69/140 (49%), Gaps = 8/140 (5%)

Query: 4   EQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           E       ++  +GL+PV+   A +GEVLM  YMN EAL KT+E+G+  ++SR++Q+LW 
Sbjct: 16  EGLLLAPKFD-CNGLIPVVTTDANTGEVLMHAYMNEEALVKTIETGEGHYYSRSRQQLWH 74

Query: 64  KGETSGNFLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDTAH-----QWLFLY 116
           KG++SG    V  +A D D D L +       G +CH G  SCF                
Sbjct: 75  KGQSSGLVQKVQQLAIDDDQDCLWMQVEVAGSGASCHVGYRSCFYRCIPTGKSAIDSQEP 134

Query: 117 QLEQLLAERKSADPETSYTA 136
                    K+ DP+T Y  
Sbjct: 135 IQLTFTETEKTFDPKTVYGN 154


>UniRef50_Q03VY1 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leuconostoc mesenteroides
           RepID=Q03VY1_LEUMM
          Length = 132

 Score =  148 bits (374), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 49/128 (38%), Positives = 71/128 (55%), Gaps = 2/128 (1%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M+  +   + + +  +GL+P ++  A +   LMLGYMN E+   T  +G+  F+SR +Q 
Sbjct: 1   MIGTE--PDFNKQSQNGLIPAVIVDAETKAFLMLGYMNKESYSLTKSTGQTWFWSRERQE 58

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW KGETSGN   VVS+  DCD DTLL+  NP GP CH    SCF +T          + 
Sbjct: 59  LWHKGETSGNIQQVVSMTLDCDLDTLLIHVNPAGPACHTNAYSCFFNTIKGEGLADANQA 118

Query: 121 LLAERKSA 128
            +A + + 
Sbjct: 119 TIANKWTD 126


>UniRef50_Q7UJC4 Phosphoribosyl-AMP cyclohydrolase n=3 Tax=Bacteria RepID=HIS3_RHOBA
          Length = 126

 Score =  147 bits (372), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 41/108 (37%), Positives = 59/108 (54%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
              L+P I Q A +G VLML +MN EA D+T+   +  +FSR++ +LW KG+TSG+   V
Sbjct: 18  GQPLLPAIAQDATTGRVLMLAWMNREAWDETISGNRAVYFSRSRGKLWRKGDTSGHAQVV 77

Query: 75  VSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
             I  DCD DT+L+     G  CH+   SCF          +  E+ +
Sbjct: 78  REIRVDCDADTILLSVEQTGAACHENYESCFFRRVDPDGTTHITEERI 125


>UniRef50_C4G191 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G191_ABIDE
          Length = 295

 Score =  147 bits (372), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 49/113 (43%), Positives = 66/113 (58%), Gaps = 1/113 (0%)

Query: 7   RRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
             ++ ++   GL+P IVQ   +G VL + YMN E+L+ TL      F+SR+++ LW KGE
Sbjct: 18  IDKIKFD-EKGLVPCIVQDYTTGRVLTVAYMNRESLEITLRKKLTCFYSRSRKELWLKGE 76

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLE 119
           TSGN+ +VVSI  DCD D LLV     G  CH+G  SCF DT         +E
Sbjct: 77  TSGNYQHVVSIEADCDYDALLVRVVRDGAACHRGNESCFDDTMKIEFEENIME 129


>UniRef50_B6BVA2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=beta proteobacterium KB13
           RepID=B6BVA2_9PROT
          Length = 129

 Score =  147 bits (372), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 48/121 (39%), Positives = 72/121 (59%), Gaps = 2/121 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
               ++ W    GL+P I+Q   S +V+M+ +MN EAL KT+E+ +  F+SR++ ++W K
Sbjct: 2   NVFDQIKW-NDQGLIPAILQDNNSMKVVMMAWMNKEALSKTIETKQCYFYSRSRNKIWLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLAN-PIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLA 123
           GE SGNF NVVSI  DCD D+LLV  N   G +CH G +SCF +          + + + 
Sbjct: 61  GEESGNFHNVVSILVDCDIDSLLVKVNVKSGISCHTGRNSCFYNEISDNGDTINIIEEVL 120

Query: 124 E 124
           +
Sbjct: 121 K 121


>UniRef50_UPI0001C41B27 phosphoribosyl-AMP cyclohydrolase HisI n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C41B27
          Length = 137

 Score =  147 bits (371), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 41/136 (30%), Positives = 70/136 (51%), Gaps = 9/136 (6%)

Query: 9   ELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKG 65
           EL++    G   L+  + Q   + +VLM+ +MN EA+++TL++ K  ++S ++Q+ W KG
Sbjct: 2   ELNFRLNMGGEDLVIAVAQDYETNDVLMVAFMNKEAVEQTLKTKKAHYYSTSRQKQWLKG 61

Query: 66  ETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT------AHQWLFLYQLE 119
           E+SGN   V  +  DCD D +++  + IG  CH+G  SCF               L   +
Sbjct: 62  ESSGNVQTVKEMYIDCDADAIIMKVDQIGAACHEGYRSCFFRQLDIDKENIDLDSLTDED 121

Query: 120 QLLAERKSADPETSYT 135
             +   +  DP+  Y 
Sbjct: 122 ISIISERLFDPKEMYG 137


>UniRef50_Q11JM5 Phosphoribosyl-AMP cyclohydrolase n=5 Tax=Alphaproteobacteria
           RepID=HIS3_MESSB
          Length = 139

 Score =  146 bits (369), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 44/100 (44%), Positives = 61/100 (61%), Gaps = 3/100 (3%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GL+  +V  A  G +LM+ +MN EAL KTLE+G   ++SR++  LW KGETSGN
Sbjct: 27  RFD-ANGLITAVVTDAGDGTLLMVAHMNAEALAKTLETGIAHYWSRSRSSLWKKGETSGN 85

Query: 71  FLNVVSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDT 108
             +V SI+ DCD D +L+       G TCH G  SCF   
Sbjct: 86  LQHVESISTDCDQDAVLLKVRVGGEGATCHTGRRSCFYRN 125


>UniRef50_C9RPU9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RPU9_FIBSS
          Length = 116

 Score =  146 bits (369), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 51/114 (44%), Positives = 67/114 (58%), Gaps = 5/114 (4%)

Query: 1   MLTEQQRRELDWEKTDG---LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRT 57
           M  E   +E+ +E   G   L P IVQ A  G+VLM+ +MN EAL +T E G++ F+SR+
Sbjct: 1   MKFEDLIKEVKFEVEFGGVKLAPAIVQDADKGDVLMMAWMNEEALRRTHECGEMVFWSRS 60

Query: 58  KQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGP--TCHKGTSSCFGDTA 109
           ++  W KG+TSGN + VV  A DCD+D LL      GP   CH G  SCF  T 
Sbjct: 61  RKEYWHKGDTSGNVMTVVEWAADCDSDALLFKVRMKGPQVACHTGARSCFFKTC 114


>UniRef50_C7RQA3 Phosphoribosyl-AMP cyclohydrolase n=20 Tax=Proteobacteria
           RepID=C7RQA3_9PROT
          Length = 142

 Score =  146 bits (369), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 40/107 (37%), Positives = 64/107 (59%), Gaps = 1/107 (0%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +   EL +++  GL+  I Q   + E+LML +MN  A+++TL +G   ++SR+++ +W K
Sbjct: 18  EVLDELAFDQ-QGLVAAIAQQFDTREMLMLAWMNRAAIEETLATGLACYWSRSRRCMWRK 76

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQ 111
           GETSG    V+    DCD D +L+L + +G  CH G SSCF +    
Sbjct: 77  GETSGCRQRVIETRFDCDGDAILLLVDQLGGACHTGRSSCFYNAVRN 123


>UniRef50_A3MSF2 Phosphoribosyl-AMP cyclohydrolase n=6 Tax=Thermoproteaceae
           RepID=HIS3_PYRCJ
          Length = 128

 Score =  146 bits (368), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 38/104 (36%), Positives = 61/104 (58%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           +  + L++    G +  +VQ   +GEVLM+G+M+P A+  TL +G   ++S +++R+W K
Sbjct: 14  RIAKSLNYRHIGGTVVAVVQDVETGEVLMVGHMDPVAVVLTLTTGLAHYYSTSRKRIWLK 73

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
           GETSG++  V     DCD D +++    IG  CH G  SCF   
Sbjct: 74  GETSGHYQIVKEFRTDCDGDAVVLKVVQIGAACHTGARSCFSSP 117


>UniRef50_A1KJ22 Phosphoribosyl-AMP cyclohydrolase n=17 Tax=Actinomycetales
           RepID=HIS3_MYCBP
          Length = 115

 Score =  146 bits (368), Expect = 5e-34,   Method: Composition-based stats.
 Identities = 42/105 (40%), Positives = 63/105 (60%), Gaps = 1/105 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           L  +    L     DGL+  +VQ   SG+VLM+ +MN EAL +TL++ + T++SR++   
Sbjct: 3   LDPKIAARLK-RNADGLVTAVVQERGSGDVLMVAWMNDEALARTLQTREATYYSRSRAEQ 61

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           W KG TSG+  +V S+  DCD D +L+  + +G  CH G  SCF 
Sbjct: 62  WVKGATSGHTQHVHSVRLDCDGDAVLLTVDQVGGACHTGDHSCFD 106


>UniRef50_C7NRL7 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=cellular organisms
           RepID=C7NRL7_HALUD
          Length = 138

 Score =  145 bits (367), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 49/126 (38%), Positives = 69/126 (54%), Gaps = 10/126 (7%)

Query: 9   ELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETS 68
           +L +E  + L P + Q A SG+VLML Y+  EALD+T E+G   ++SR++  LW KGETS
Sbjct: 22  DLAFEDNEYL-PAVAQDAESGDVLMLAYVTREALDRTRETGLAHYYSRSRDELWQKGETS 80

Query: 69  GNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSA 128
           GN  ++  I  DCD D LL +    G  CH G  SCF  T         ++  +   +  
Sbjct: 81  GNVQHLKEIRVDCDGDALLYVIEQDGGACHTGFQSCFHRT---------IDGEVVGERVF 131

Query: 129 DPETSY 134
           DP+  Y
Sbjct: 132 DPDDVY 137


>UniRef50_B1XSV4 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Polynucleobacter
           necessarius RepID=B1XSV4_POLNS
          Length = 140

 Score =  145 bits (366), Expect = 9e-34,   Method: Composition-based stats.
 Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 2/103 (1%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
                + W    GL+PVI Q   S ++LM+ +MN +AL +TL  G+  +++R++Q+LW K
Sbjct: 21  SWLDAVTW-NEQGLVPVIAQEIGSKDILMMAWMNRDALLETLRLGEAVYWTRSRQKLWHK 79

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANP-IGPTCHKGTSSCFG 106
           GE SG+   V  I  DCD DT+L+L     G  CH G  SCF 
Sbjct: 80  GEESGHTQKVKEIHLDCDGDTILLLVEQKDGIACHTGEHSCFF 122


>UniRef50_Q2NAM2 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadales
           RepID=HIS3_ERYLH
          Length = 125

 Score =  144 bits (364), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 45/98 (45%), Positives = 62/98 (63%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  DGL+  +VQH  + EVLM+ +MN +ALD T ++G   FFSR++Q LW KG TSGN
Sbjct: 18  KFDS-DGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGN 76

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L V  +  DCD D +++L  P GP CH G  +CF   
Sbjct: 77  TLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRE 114


>UniRef50_A3WCC9 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Erythrobacter sp. NAP1
           RepID=A3WCC9_9SPHN
          Length = 143

 Score =  143 bits (362), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 47/98 (47%), Positives = 65/98 (66%), Gaps = 1/98 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++   GL+  +V  + + EVL++ +MN +AL KT E+GKV F+SR++  LW KGETSGN
Sbjct: 32  KFD-ASGLLASVVIDSRTKEVLVIAFMNADALQKTRETGKVHFWSRSRSSLWMKGETSGN 90

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            L+V  I  DCD D L++ A P GPTCH G +SCF   
Sbjct: 91  VLSVDEIRVDCDQDALVIYATPAGPTCHTGETSCFYRK 128


>UniRef50_A6P0M4 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P0M4_9BACE
          Length = 108

 Score =  143 bits (361), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 49/91 (53%), Positives = 66/91 (72%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+PVI+Q A + EVLMLG+ N EA++ TL++    F+SR++Q+LW KGETSG+FL+V  +
Sbjct: 13  LIPVIIQDADTLEVLMLGFTNKEAVELTLKTKTAWFWSRSRQKLWNKGETSGHFLHVERM 72

Query: 78  APDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
             DCD DTLL   +P+GPTCH G  SCF   
Sbjct: 73  VTDCDTDTLLYFCHPVGPTCHTGAKSCFFRE 103


>UniRef50_C6QCS2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCS2_9RHIZ
          Length = 149

 Score =  143 bits (361), Expect = 4e-33,   Method: Composition-based stats.
 Identities = 50/132 (37%), Positives = 68/132 (51%), Gaps = 19/132 (14%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
           +DGL+P IV  A SG VLM  +MN +AL +T+ +G   F+SR++ +LW KGE SGN L+V
Sbjct: 29  SDGLIPAIVSDARSGNVLMFAHMNEQALQQTIATGFAHFWSRSRGKLWKKGEESGNLLSV 88

Query: 75  VSIAPDCDNDT--LLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
             +  DCD D   LL      G  CH G  SCF                   R  A P++
Sbjct: 89  KEVRTDCDQDVVWLLADVEGDGVACHTGAPSCFYR-----------------RLIASPDS 131

Query: 133 SYTAKLYASGTK 144
           S +  L ++G  
Sbjct: 132 SGSLSLESAGLP 143


>UniRef50_Q9X3W1 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Sphingomonadaceae
           RepID=HIS3_ZYMMO
          Length = 124

 Score =  142 bits (359), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 36/111 (32%), Positives = 64/111 (57%), Gaps = 1/111 (0%)

Query: 12  WEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNF 71
           W+   GL+  ++  A +G +LM+ +MN E+ + ++ + + TF+SR+++++W KGE SG+ 
Sbjct: 15  WD-EKGLITAVLTDAKTGLLLMVAHMNKESFELSMATKEATFWSRSRKKIWRKGEESGHV 73

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLL 122
           + +  I  DCD DTL +   P+GP CH G  SCF         +   +  +
Sbjct: 74  MKIQEIRIDCDQDTLWLKVIPMGPACHTGAQSCFYRLVEDGHLVTIPKDKI 124


>UniRef50_Q1PZK9 Similar to bifunctional phosphoribosyl-AMP cyclohydrolase/
           phosphoribosyl-ATP pyrophosphatase n=1 Tax=Candidatus
           Kuenenia stuttgartiensis RepID=Q1PZK9_9BACT
          Length = 127

 Score =  141 bits (357), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 44/130 (33%), Positives = 66/130 (50%), Gaps = 5/130 (3%)

Query: 5   QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTK 64
           Q   +L +    GL+P ++  A  G+ L L YMN +A+ KT+E+GK+  F R++ RL  K
Sbjct: 2   QLLEKLHF-NEKGLIPAVIADATDGKALTLCYMNKDAVVKTIETGKIHVFRRSQNRLMLK 60

Query: 65  GETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
           GETSG+  +V  I  DC+ ++L+ +       CH G  SC+                + E
Sbjct: 61  GETSGHIQSVKRIYFDCEGNSLVFMVEQHVAACHAGYKSCYYREYIPQT----NSIQVVE 116

Query: 125 RKSADPETSY 134
            K  DPE  Y
Sbjct: 117 EKVFDPENVY 126


>UniRef50_B8EQR3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Methylocella silvestris
           BL2 RepID=B8EQR3_METSB
          Length = 141

 Score =  139 bits (351), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 41/96 (42%), Positives = 54/96 (56%), Gaps = 2/96 (2%)

Query: 15  TDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNV 74
            DGL+  + + A  GE+LM+ YMN EAL  TL +G+  ++SR++Q +W KG TSG    V
Sbjct: 30  PDGLIICVTRAAEDGEILMVAYMNAEALRLTLTTGEAHYWSRSRQSIWRKGATSGQTQKV 89

Query: 75  VSIAPDCDNDTLLVLAN--PIGPTCHKGTSSCFGDT 108
             I  DCD D LL+       G  CH G  SCF   
Sbjct: 90  REIRADCDQDALLLTIEAGGDGGACHTGRRSCFYRR 125


>UniRef50_UPI0001744401 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Verrucomicrobium spinosum
           DSM 4136 RepID=UPI0001744401
          Length = 141

 Score =  139 bits (351), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 35/108 (32%), Positives = 56/108 (51%), Gaps = 2/108 (1%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
           + +       ++  DGL+P I     + E LM+ YMN E L  T+  G+  ++SR+++ +
Sbjct: 19  IEQGLVLAPKFD-ADGLIPAIALDHQTNEPLMVAYMNEETLRMTIALGEAVYYSRSRKEI 77

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPT-CHKGTSSCFGDT 108
           W KG+TSG F  V  I  DCD D +++    +G   CH    +CF   
Sbjct: 78  WHKGKTSGEFQVVKEIRVDCDQDAVILKVEQLGGGCCHTKAPTCFYRK 125


>UniRef50_A8A9Z2 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=HIS3_IGNH4
          Length = 129

 Score =  133 bits (334), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 36/111 (32%), Positives = 60/111 (54%), Gaps = 1/111 (0%)

Query: 2   LTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRL 61
             ++    L++   D  +  + Q   SG+VLM+  MN EA+ KTL +G V ++S++++ L
Sbjct: 8   EAKRIAERLNYRWPDRTVVAVAQEYKSGKVLMVASMNKEAVIKTLTTGIVHYWSKSRKEL 67

Query: 62  WTKGETSGNFLNVVSIAPDCDNDTLLVLANPIG-PTCHKGTSSCFGDTAHQ 111
           W KG TSG+   +     DCD D++L++        CH+G  SCF     +
Sbjct: 68  WVKGATSGHVQVLEKFYYDCDADSVLLVVRQASLIACHEGYRSCFHYKVEE 118


>UniRef50_A6URR6 Phosphoribosyl-AMP cyclohydrolase n=13 Tax=Methanococcales
           RepID=HIS3_METVS
          Length = 136

 Score =  132 bits (333), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 36/102 (35%), Positives = 55/102 (53%), Gaps = 3/102 (2%)

Query: 9   ELDWEKTDG--LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGE 66
           +L + K D   L+  I        VLM  +M+ E+L  TL++G + +FS ++ ++W KGE
Sbjct: 20  DLKFRKIDDKELLIAIAIDKYKN-VLMTAFMDKESLKMTLKTGLMHYFSTSRNKIWMKGE 78

Query: 67  TSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDT 108
            S N   V+ +  DCD D LL +    G  CH+G  SCF + 
Sbjct: 79  ESKNVQKVLEVFKDCDGDALLFIVEQTGWACHEGYMSCFHNK 120


>UniRef50_A1ZDC3 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Microscilla marina ATCC
           23134 RepID=A1ZDC3_9SPHI
          Length = 130

 Score =  130 bits (326), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 43/94 (45%), Positives = 60/94 (63%), Gaps = 1/94 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            +EK  GL+PV+VQ   SG+VLMLGY N  AL +TL++G  TF+S ++  LWTKG+TSG+
Sbjct: 14  QFEKRGGLLPVVVQEQASGKVLMLGYANEAALQETLDTGYATFWSTSRNELWTKGKTSGD 73

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSS 103
           +L +  I  DCD D L+     +G   CH    +
Sbjct: 74  YLKITHILTDCDQDALVYQVTMMGAGACHTKDEN 107


>UniRef50_UPI0001910D6A bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP
           pyrophosphatase protein n=2 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI0001910D6A
          Length = 157

 Score =  124 bits (312), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 74/81 (91%), Positives = 77/81 (95%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           MLTEQQRRELDWEKTDGLMP IVQHAVSGEVL LGYMNP+ALDKT+ESG VTFFSRTKQR
Sbjct: 77  MLTEQQRRELDWEKTDGLMPAIVQHAVSGEVLTLGYMNPQALDKTIESGHVTFFSRTKQR 136

Query: 61  LWTKGETSGNFLNVVSIAPDC 81
           LWTKGETSG+ LNVVSIAPDC
Sbjct: 137 LWTKGETSGHVLNVVSIAPDC 157


>UniRef50_Q1NG03 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Sphingomonas sp. SKA58
           RepID=Q1NG03_9SPHN
          Length = 157

 Score =  123 bits (310), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 43/115 (37%), Positives = 61/115 (53%), Gaps = 2/115 (1%)

Query: 11  DWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGN 70
            ++  +GLMP IV +A    VLMLGYMN EAL +TL + +  F+SR+++ LW KGE SG 
Sbjct: 22  RFD-AEGLMPTIVVNANDQMVLMLGYMNAEALGRTLWTRQAHFWSRSRRALWRKGEHSGF 80

Query: 71  FLNVVSIAPDCDNDTLLVLANPIGP-TCHKGTSSCFGDTAHQWLFLYQLEQLLAE 124
              V  +  D D D L+++     P +CH G  SCF       +   +    L  
Sbjct: 81  RQRVDHVLVDDDQDALILMVTIDAPGSCHVGFRSCFYREVDLDMLPDKSPVRLRR 135


>UniRef50_Q8F8K4 Phosphoribosyl-AMP cyclohydrolase n=4 Tax=Leptospira
           RepID=HIS3_LEPIN
          Length = 187

 Score =  122 bits (306), Expect = 8e-27,   Method: Composition-based stats.
 Identities = 34/118 (28%), Positives = 57/118 (48%), Gaps = 5/118 (4%)

Query: 16  DGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVV 75
             L+PV+      G++LM  + N E+   +L++G   +FSR++ +LW KG+TSG+   ++
Sbjct: 75  KNLVPVVAIDLQ-GQILMQAFGNEESQTLSLKTGYAHYFSRSRNQLWKKGDTSGHTQKIL 133

Query: 76  SIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETS 133
            I    D   L+         CH+G  SCF     +        +LL   ++  PE S
Sbjct: 134 QILSPTDRSFLVYQVEQEVAACHEGYYSCFFRERME----GVTWKLLPVPRNFLPEKS 187


>UniRef50_O33778 Phosphoribosyl-AMP cyclohydrolase n=12 Tax=Sulfolobaceae
           RepID=HIS3_SULSO
          Length = 85

 Score =  121 bits (305), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 35/79 (44%), Positives = 49/79 (62%)

Query: 33  MLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSIAPDCDNDTLLVLANP 92
           M+G MN EAL KTL +G + F+S ++++LW KGETSGNF  +     DCD D +L     
Sbjct: 1   MVGNMNREALFKTLTTGYLHFWSLSRKKLWLKGETSGNFQIIEEFKVDCDADAVLFKVTS 60

Query: 93  IGPTCHKGTSSCFGDTAHQ 111
           +GP CH G  +CF  +  +
Sbjct: 61  LGPICHTGNYTCFYRSYDE 79


>UniRef50_B0SHA6 Phosphoribosyl-AMP cyclohydrolase n=2 Tax=Leptospira biflexa
           serovar Patoc RepID=B0SHA6_LEPBA
          Length = 202

 Score =  115 bits (287), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 33/109 (30%), Positives = 52/109 (47%), Gaps = 1/109 (0%)

Query: 13  EKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFL 72
           +    L P + Q  ++G+ LML +   E+L   +ESG  T+FSR++   W KGE SG+F 
Sbjct: 89  DSMPPLSPFLAQD-LTGKDLMLAWGKKESLIHAIESGNGTYFSRSRNGKWVKGEESGHFQ 147

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQL 121
            +  I    +   +  + + IG  CH G  SCF     Q   +  +   
Sbjct: 148 KLKQIYVHSNPFFVKYITDQIGAACHTGYYSCFFRELGQNESVSFVYSN 196


>UniRef50_A5KSK8 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=candidate division TM7
           genomosp. GTL1 RepID=A5KSK8_9BACT
          Length = 125

 Score =  113 bits (284), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 47/104 (45%), Positives = 59/104 (56%), Gaps = 7/104 (6%)

Query: 10  LDWEKTDGLMPVIVQHAVSGEV------LMLGYMNPEALDKTLESGKVTFFSRTKQRLWT 63
           +D +  + L+   V       V       M GYMN  A++ TL  G VTFFSRT  +LW 
Sbjct: 20  VDPKSNEALVAATVVDVQCLAVDGIAAIRMQGYMNRAAIEATLSDGIVTFFSRTTGKLWK 79

Query: 64  KGETSGNFLNVV-SIAPDCDNDTLLVLANPIGPTCHKGTSSCFG 106
           KGETSGN L +   I  DCD D+LL+ A P+G TCH G+ SCF 
Sbjct: 80  KGETSGNILRLRGDIYVDCDGDSLLINAEPVGSTCHTGSQSCFE 123


>UniRef50_C6UMY7 Putative phosphoribosyl-AMP cyclohydrolase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMY7_HODCD
          Length = 101

 Score =  112 bits (281), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 35/95 (36%), Positives = 50/95 (52%), Gaps = 2/95 (2%)

Query: 18  LMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQRLWTKGETSGNFLNVVSI 77
           L+PV+V    SG++LML Y +   L+ T  +G   ++SR++Q +W KG +SG    V ++
Sbjct: 7   LLPVVVTDWYSGKLLMLAYCDELCLNLTFHTGVAHYYSRSRQTIWVKGLSSGRLQLVQAV 66

Query: 78  APDCDNDTL--LVLANPIGPTCHKGTSSCFGDTAH 110
             DCD D L   VL    G  CH    SCF     
Sbjct: 67  YRDCDGDALNFRVLVLGDGRVCHTRQVSCFHTRLW 101


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  108 bits (269), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 39/137 (28%), Positives = 66/137 (48%), Gaps = 14/137 (10%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPET 132
            ++ ++ DCDND +  +    G  CH     CFG+       + +LE+ L  RK + PE 
Sbjct: 166 ELLQVSLDCDNDAIKFVVRQKGRFCHLEQDGCFGNL----TGIARLEKTLKARKESAPEG 221

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SYTA+L+ +  K +  K+ EE  E   A     + ++  EA+DL+Y  L      G+ + 
Sbjct: 222 SYTARLF-NDEKLLRAKIMEEAEELCDA---KTKEDVAFEAADLIYFALTKAVSAGVSVA 277

Query: 193 TVIENL------RKRHQ 203
            + ++L       KR +
Sbjct: 278 DIEKSLDAKGWKVKRRK 294


>UniRef50_Q0FX88 Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Roseovarius sp. HTCC2601
           RepID=Q0FX88_9RHOB
          Length = 164

 Score =  106 bits (266), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 41/149 (27%), Positives = 57/149 (38%), Gaps = 9/149 (6%)

Query: 1   MLTEQQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNPEALDKTLESGKVTFFSRTKQR 60
           M       +L     DGLMP     A SGE+LMLG+M  EA   T+E+G+  +FSR +Q 
Sbjct: 1   MEGTGLAPKL---GPDGLMPCRTTDAESGELLMLGWMKAEAFRPTIETGEAQYFSRARQV 57

Query: 61  LWTKGETSGNFLNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQ 120
           LW +G  SG  L +V        D  L      G   H  + +       +         
Sbjct: 58  LWHEGAASGLVLKLVEARI---EDAQLRANRSRGR--HSKSDNHMYYKRRRAAGCPPSYF 112

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQK 149
               R    P  S +       +  I+ K
Sbjct: 113 DRTGRDMKAP-NSTSGPAMKKASPGISAK 140


>UniRef50_Q04V97 Phosphoribosyl-ATP pyrophosphatase n=15 Tax=Bacteria
           RepID=HIS2_LEPBJ
          Length = 92

 Score =  103 bits (256), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 48/91 (52%), Positives = 61/91 (67%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
             FL QLE +L +RK   P+ SYTA L+  G  RI +KVGEE  E  +AA   D+ ELT+
Sbjct: 1   MEFLLQLENILKKRKQDLPDKSYTADLFRGGVDRILKKVGEEAGEVIIAAKNSDKKELTH 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+DL++HL VLL +Q L L  V+E LRKRH
Sbjct: 61  EAADLLFHLQVLLVEQELSLQDVVEELRKRH 91


>UniRef50_A5CZ71 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=cellular organisms
           RepID=HIS2_PELTS
          Length = 98

 Score =  102 bits (255), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 34/95 (35%), Positives = 50/95 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
             +   +  L +++ +R+   P+ SYTA L+  G  +I +K+GEE  E  +AA       
Sbjct: 1   MGEKDIIRDLYEVILDRRQKQPDGSYTAYLFEQGEDKILKKIGEEAAEVLIAAKNGGGAA 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E +DL+YHLLVLL   GL    V+  L  R Q
Sbjct: 61  LVGEMADLVYHLLVLLAWHGLAPEDVLAELAARRQ 95


>UniRef50_A7FU84 Phosphoribosyl-ATP pyrophosphatase n=20 Tax=Bacteria
           RepID=HIS2_CLOB1
          Length = 110

 Score =  101 bits (252), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 32/95 (33%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
            ++   +  L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   D  E
Sbjct: 1   MNRNNVIDSLFNIIEDRKDKPIEGSYTGYLFEKGLDKILKKVGEESSEVIIAAKNEDEEE 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  DL YH++VL+ ++ + L  + + L KR +
Sbjct: 61  LIKEICDLTYHIMVLMVEKQIKLDDIEKELEKRRE 95


>UniRef50_A6LT24 Phosphoribosyl-ATP pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=A6LT24_CLOB8
          Length = 108

 Score = 98.4 bits (244), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 48/90 (53%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L + + +RK+   E SYT  L+  GT +I +KVGEE  E  ++   +++ E  NE
Sbjct: 3   ENIKALYETILKRKTEGEEGSYTKYLFEKGTNKILKKVGEECTEVIISCKENNKEEQINE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             DL YHLLVL+    + +  V   L KR 
Sbjct: 63  ICDLTYHLLVLMAQMNISIEEVGAELEKRR 92


>UniRef50_A0PXP9 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Clostridium
           RepID=HIS2_CLONN
          Length = 110

 Score = 98.1 bits (243), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 29/95 (30%), Positives = 51/95 (53%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 + +L  ++ +RK    E SYT  L+  G  +I +KVGEE  E  +AA   ++ +
Sbjct: 1   MDNIDVIEELYNVILDRKENGKENSYTNYLFEKGIDKILKKVGEETTEVIVAAKNTNKDD 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           L  E  D++YH++VL+ ++ + L  +   L KR +
Sbjct: 61  LIAEVCDVIYHMVVLMVEKEVKLEDIKNELNKRRK 95


>UniRef50_A4EBZ9 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=A4EBZ9_9ACTN
          Length = 105

 Score = 98.1 bits (243), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 32/104 (30%), Positives = 51/104 (49%), Gaps = 1/104 (0%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G  +      +    L  L +++  R+ A P+ SYTA+L       + +K+ EE  E  +
Sbjct: 2   GVRTANVQDGNIGETLTGLAEVIHGRRDASPQESYTARLLTDVEDELLKKLAEEASEVIM 61

Query: 160 AATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL-RKRH 202
           A   +D   +  EA DL+YHLLV L+  G+ L  +   L  +RH
Sbjct: 62  ACKDNDHDHIRYEAGDLVYHLLVTLERYGITLDELAGELNARRH 105


>UniRef50_A5FYE6 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Alphaproteobacteria
           RepID=HIS2_ACICJ
          Length = 133

 Score = 97.7 bits (242), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 36/110 (32%), Positives = 56/110 (50%), Gaps = 1/110 (0%)

Query: 93  IGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGE 152
           +G   H          A     L +L   +  RK+ADP  S++A+L + G  ++AQK GE
Sbjct: 1   MGAASHPPV-PLLNPAAPNAQVLDRLWSTILARKAADPLVSHSARLLSRGVNKVAQKFGE 59

Query: 153 EGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           E VE  + A   +R  L  E++D++YHLLV+    G+    V   L++R 
Sbjct: 60  ESVECLIEAVAGNRTALIAESADVLYHLLVMWVAAGVRPEDVWLELQRRE 109


>UniRef50_C6QFL0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QFL0_9RHIZ
          Length = 127

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 37/103 (35%), Positives = 53/103 (51%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
                   +       L +L  L+  R+S   + SYTA+L  +G +R A+K GEE VET 
Sbjct: 8   SSAPPRDKEFMSDTHTLTKLAALIHSRRSDSADKSYTAQLLNAGPERCAKKFGEEAVETV 67

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           +AA   D   L  EA+D +YHLLVLL+ + +    V+  L  R
Sbjct: 68  IAALGSDASALRAEAADTLYHLLVLLESRHVAFDDVLRVLEGR 110


>UniRef50_A5N7R3 HisE n=2 Tax=Clostridium kluyveri RepID=A5N7R3_CLOK5
          Length = 105

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 51/90 (56%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            + +L  ++ +RK    + SYT  L+  G  +I +KVGEE  E  +A+   ++ +   E 
Sbjct: 1   MVEELYNVIKDRKENPIDGSYTNYLFKEGLDKILKKVGEESSEVIIASKNDNKEDKICEI 60

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            DL+YH+LVL+ ++ + L  + + L KR Q
Sbjct: 61  CDLIYHVLVLMANENITLEELRKELEKRRQ 90


>UniRef50_Q2VYJ1 Phosphoribosyl-ATP pyrophosphatase n=19 Tax=Alphaproteobacteria
           RepID=HIS2_MAGSA
          Length = 109

 Score = 96.5 bits (239), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 42/92 (45%), Positives = 56/92 (60%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +L  ++A RK  DP+ SYTAKL+A G  +IAQK GEE VET +AA    + EL
Sbjct: 3   QDSKILEELYTVIASRKGTDPDKSYTAKLFARGRGKIAQKFGEEAVETVVAALSEGKDEL 62

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++D +YHLLVL  D G++   V   L +R
Sbjct: 63  VGESADTLYHLLVLWADCGVEPAKVWAELARR 94


>UniRef50_Q5FA47 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Betaproteobacteria
           RepID=HIS2_NEIG1
          Length = 107

 Score = 96.1 bits (238), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 32/93 (34%), Positives = 48/93 (51%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  ++Q + +RKSADP  SY A+L   G  +I +KV EE  E  +A+   D   L
Sbjct: 1   MGDSVLSAIQQTIIQRKSADPSESYVAQLLHKGEDKILKKVIEEAGEVLMASKDKDPSHL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             E +DL +H ++LL    L    V++ L +R 
Sbjct: 61  VYEVADLWFHTMILLTHHDLKAEDVLDELSRRQ 93


>UniRef50_B7INA5 Phosphoribosyl-ATP pyrophosphatase n=68 Tax=Firmicutes
           RepID=HIS2_BACC2
          Length = 107

 Score = 96.1 bits (238), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 27/84 (32%), Positives = 48/84 (57%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY 178
            + + ERK +    SYT  L++ G  +I +K+GEE  E  +A   +D+ E+  E  D+ Y
Sbjct: 9   YKTIEERKESPLPESYTNYLFSKGEDKILKKIGEECAEVIIACKNNDKEEVVKEMVDVFY 68

Query: 179 HLLVLLQDQGLDLTTVIENLRKRH 202
           H  VLL ++ + L  V+  +++R+
Sbjct: 69  HCFVLLAEKNIALEDVMREVKERN 92


>UniRef50_Q2YAV2 Phosphoribosyl-ATP pyrophosphatase n=8 Tax=Betaproteobacteria
           RepID=HIS2_NITMU
          Length = 121

 Score = 96.1 bits (238), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 34/94 (36%), Positives = 49/94 (52%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFE 168
                 L++L + +  RK +DP  SY AKL   G  +I +K+ EE  E  LA+   D   
Sbjct: 1   MSDPDILFRLAETIEARKQSDPHASYVAKLLHDGRDKILKKIAEESAEVLLASKDGDSTH 60

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +  E +DL +H LVLL    L L  V++ LR+R 
Sbjct: 61  VVRETADLWFHCLVLLAHHNLKLGDVLDELRRRE 94


>UniRef50_Q2KTS9 Phosphoribosyl-ATP pyrophosphatase n=7 Tax=Burkholderiales
           RepID=HIS2_BORA1
          Length = 116

 Score = 95.4 bits (236), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 28/74 (37%), Positives = 38/74 (51%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP+TSY AKL A G     +K+GEE  E  +AA       + +E +DL +H LV L    
Sbjct: 29  DPQTSYAAKLLAKGPDAFLKKIGEEATELVMAAKDGRPERIVSETADLWFHCLVTLAHYN 88

Query: 189 LDLTTVIENLRKRH 202
           L    V+  L +R 
Sbjct: 89  LRPEDVLAELARRE 102


>UniRef50_B9ZNB1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZNB1_9GAMM
          Length = 125

 Score = 95.0 bits (235), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 34/99 (34%), Positives = 53/99 (53%)

Query: 103 SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
               D       L  L +++ +R+ ADPE SY AKL+A G   + +K+GEE  ET +A  
Sbjct: 3   GRASDARAGAELLSALAEVIEQRRQADPEQSYVAKLHARGLDEMLKKLGEESAETIIAGK 62

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             D   L +E +DL +H L++L  +G     V++ L +R
Sbjct: 63  NDDSDALVSEMADLWFHSLIVLAARGRHPDDVLDELARR 101


>UniRef50_B0MMD1 Putative uncharacterized protein n=3 Tax=Clostridiales
           RepID=B0MMD1_9FIRM
          Length = 114

 Score = 95.0 bits (235), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 35/76 (46%), Positives = 49/76 (64%)

Query: 128 ADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQ 187
             PE SYT  L+  G  +I +KVGEE  ET +AA   D  EL NE +DL+YH++VL  D+
Sbjct: 24  NAPEKSYTCYLFDKGVDKICKKVGEEAAETIIAAKNADNDELKNEINDLLYHVMVLCADR 83

Query: 188 GLDLTTVIENLRKRHQ 203
           GL+ + V E L +R++
Sbjct: 84  GLEWSEVEEVLSERNE 99


>UniRef50_Q0A5D4 Phosphoribosyl-ATP pyrophosphatase n=23 Tax=cellular organisms
           RepID=HIS2_ALHEH
          Length = 109

 Score = 94.2 bits (233), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 36/91 (39%), Positives = 50/91 (54%)

Query: 111 QWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELT 170
           Q   L  L ++L ER+ ADP TSY AKL+  G   I +KVGEE  E  +AA   DR ++ 
Sbjct: 4   QRDILKALAEVLEERRQADPATSYVAKLHHKGLDAILKKVGEEATEAVVAAKGGDRSQVI 63

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            E +DL +H L++L         V+  L +R
Sbjct: 64  YETADLWFHSLIMLSACDAGPDDVLAELERR 94


>UniRef50_B6BVA1 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=beta
           proteobacterium KB13 RepID=B6BVA1_9PROT
          Length = 104

 Score = 93.8 bits (232), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 36/90 (40%), Positives = 59/90 (65%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
              L +L+QL+  +K +DP  SYTAKL++ G + I +K GEE +E  +A+   ++  + N
Sbjct: 1   MSELDELQQLIESKKDSDPSLSYTAKLFSQGIEEIQKKFGEESIELIIASNQDNKKNVIN 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           E++D++YHLLVLL ++ + L  VI  L +R
Sbjct: 61  ESADVLYHLLVLLSEKSVTLKEVISELERR 90


>UniRef50_Q0BPX5 Phosphoribosyl-ATP pyrophosphatase n=25 Tax=Alphaproteobacteria
           RepID=HIS2_GRABC
          Length = 160

 Score = 93.8 bits (232), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 35/102 (34%), Positives = 57/102 (55%)

Query: 101 TSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA 160
           +     D  +    L +L +++ +R+ ADP  S++A+L + G  ++AQK GEE VE  + 
Sbjct: 32  SPLADIDPDNAVQVLNRLWEVVMQRRDADPAVSHSARLLSRGIGKVAQKFGEEAVECLIE 91

Query: 161 ATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A   D+  L  E++D++YHLLVL    G++   V   L KR 
Sbjct: 92  AVSGDKEALIGESADVLYHLLVLWVAVGVEPAEVWRELTKRE 133


>UniRef50_Q5NMD7 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Zymomonas mobilis
           RepID=HIS2_ZYMMO
          Length = 107

 Score = 93.8 bits (232), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 43/93 (46%), Positives = 57/93 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  +E ++AER+ A PE SY + L+  GT  IAQKVGEE VET +AA   D+  L
Sbjct: 1   MSEETLAYIESVIAERRKASPEDSYVSSLFHRGTAHIAQKVGEEAVETVIAALAQDKKSL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +EA+DL++HL VLL D+G     V   LR+R 
Sbjct: 61  ESEAADLIFHLAVLLADRGSSFENVFSELRRRE 93


>UniRef50_Q2RNA8 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Rhodospirillum rubrum
           ATCC 11170 RepID=HIS2_RHORT
          Length = 117

 Score = 93.8 bits (232), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 36/89 (40%), Positives = 52/89 (58%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L  ++A R+ ADP TSYTAKL+  G  +I QK GEE  E  +AA V    ++  E
Sbjct: 15  EIIDALAAVIASRQGADPATSYTAKLFGRGRGKIVQKFGEEAFEVGVAALVESPEQVVAE 74

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           ++D++YHL+VL  D G+    V   L +R
Sbjct: 75  SADVLYHLMVLWADVGVTPDRVWAELARR 103


>UniRef50_A1TL08 Phosphoribosyl-ATP pyrophosphatase n=26 Tax=Proteobacteria
           RepID=HIS2_ACIAC
          Length = 137

 Score = 93.8 bits (232), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 7/112 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSAD---PETSYTAKLYASGTKRIAQKVGEEG 154
           H   S       H    L +L  ++  RK A+    + SY A+L   G     +K+GEE 
Sbjct: 3   HDSLSPVAAPAVHSGDALARLAAVIESRKPANGGDADKSYVARLLHKGPDAFLKKIGEEA 62

Query: 155 VETALAATV----HDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            E  +AA       D  +L  E +DL +H ++ L   GL    V+  L +R 
Sbjct: 63  TEVVMAAKDVDHGADASKLVYEVADLWFHSMIALAHYGLAPADVVAELERRE 114


>UniRef50_Q03VY2 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Lactobacillales
           RepID=HIS2_LEUMM
          Length = 114

 Score = 93.1 bits (230), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 1/92 (1%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +   ERK      SYT  LY  G  +I +KVGEE  E  L A  ++  EL
Sbjct: 1   MPQQTIEELYEQALERKQNPQTGSYTDYLYQKGLDKILKKVGEESTEVILGAKNNN-EEL 59

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E SDL++HL+VLL ++G+ L  + + L  R
Sbjct: 60  IYETSDLLFHLMVLLVEKGVSLDDIKDELGSR 91


>UniRef50_D0KWI3 Phosphoribosyl-ATP diphosphatase n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KWI3_HALNC
          Length = 124

 Score = 93.1 bits (230), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 44/94 (46%), Positives = 60/94 (63%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
           T +    L QL  ++ +RK ADP +SY A+L+A G  +IAQKVGEEGVE ALAA   D  
Sbjct: 3   TNNPGELLAQLAAVIEQRKQADPGSSYVAQLFAKGRSKIAQKVGEEGVEVALAAVSGDNV 62

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            + +E +DL +H +VLL D GL    V++ L +R
Sbjct: 63  AIVSEMADLWFHSMVLLADAGLSHQAVLDELGER 96


>UniRef50_Q3SWF2 Phosphoribosyl-ATP pyrophosphatase n=22 Tax=Alphaproteobacteria
           RepID=HIS2_NITWN
          Length = 116

 Score = 92.7 bits (229), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 36/100 (36%), Positives = 51/100 (51%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
                    Q   ++ L  ++  R ++  + SYT KL   G    A+K+GEE VET +AA
Sbjct: 2   RERTSRRIMQRFTIHDLAAIIDARAASGGDASYTRKLLDKGPAHCARKLGEEAVETIIAA 61

Query: 162 TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              DR  L  E +DLM+H LVLL+  G+ L  V   L +R
Sbjct: 62  VEKDRHHLIAEGADLMFHFLVLLKASGVTLQDVEAVLAQR 101


>UniRef50_A1WW04 Phosphoribosyl-ATP pyrophosphatase n=14 Tax=Proteobacteria
           RepID=HIS2_HALHL
          Length = 114

 Score = 92.7 bits (229), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 31/89 (34%), Positives = 50/89 (56%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  L + + +R+ A  +TSY A+L+  G   I +KVGEE  E  +AA   +R ++  E
Sbjct: 12  DTLRALAETIEQRRGASADTSYVARLHDKGLDAILKKVGEEATEAVIAAKGGEREQVVYE 71

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +DL +H LV+L   G+ +  V+  L +R
Sbjct: 72  TADLWFHTLVMLSASGVSVDEVLAELERR 100


>UniRef50_C8SBH0 Phosphoribosyl-ATP diphosphatase n=1 Tax=Ferroglobus placidus DSM
           10642 RepID=C8SBH0_FERPL
          Length = 92

 Score = 92.3 bits (228), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
            L +L++++ ERK      SYTAKL     G  ++ +K GEE VE  LA    D+  +  
Sbjct: 1   MLEELQEIVEERKRNPTPDSYTAKLLYHEKGEDKVLEKFGEEAVELILACKNKDKESIVY 60

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EA+DL+YH +VLL    + +  V + LR+R +
Sbjct: 61  EAADLLYHFVVLLSKFDVKVEEVYDELRRRKK 92


>UniRef50_Q6U8A9 Histidine biosynthesis bifunctional protein (Fragment) n=1
           Tax=Raoultella terrigena RepID=Q6U8A9_KLETE
          Length = 88

 Score = 91.9 bits (227), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 68/80 (85%), Positives = 72/80 (90%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           ERK ADPE+SYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL NEASDLMYHL+VL
Sbjct: 9   ERKHADPESSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELKNEASDLMYHLMVL 68

Query: 184 LQDQGLDLTTVIENLRKRHQ 203
           LQDQ L L  +I NL+ RHQ
Sbjct: 69  LQDQELSLQDIIANLKSRHQ 88


>UniRef50_A7IA25 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanomicrobiales
           RepID=HIS2_METB6
          Length = 104

 Score = 91.9 bits (227), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 8/108 (7%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGV 155
           H+G              + +L  ++ ER     E SYT++L     G  ++ +KVGEE  
Sbjct: 3   HEGKEPVDLR------VIRELWGVICERADCPDENSYTSRLLQDVKGIDKVLEKVGEEST 56

Query: 156 ETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           E  LA         T EA+DL +H+LV L+   +DL+ VI  L +R +
Sbjct: 57  EFILAVKNGVPERTTEEAADLFFHVLVALRAADVDLSGVIRELERRRK 104


>UniRef50_A8A8G1 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Thermoprotei
           RepID=HIS2_IGNH4
          Length = 102

 Score = 91.9 bits (227), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 34/91 (37%), Positives = 54/91 (59%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
            FL +L  ++ +R    P+ SYTA++   G    A+K GEE VE  +A+    R  +  E
Sbjct: 3   DFLSELWLVIKKRIEEKPQGSYTAEIVKRGLPFAARKFGEESVELIVASLSEPRDSVIYE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D++YHL+VLL  +G+D   VI+ L +R +
Sbjct: 63  AADVIYHLMVLLALRGVDWAEVIKELERRSR 93


>UniRef50_C1SM22 Phosphoribosyl-ATP pyrophosphohydrolase/phosphoribosyl-ATP
           pyrophosphatase n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SM22_9BACT
          Length = 100

 Score = 91.5 bits (226), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 28/92 (30%), Positives = 51/92 (55%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                + +L +++ ERK+   + SYT +L   G+ +I +K+GEE  E   A    D  ++
Sbjct: 1   MNVEIIEKLVEVVRERKANPSDNSYTCQLLNGGSNKIIKKLGEENAELIKAILTEDDKDV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E +DL+YHL+V L+ + +    V+  L++R
Sbjct: 61  AGETADLLYHLIVALEFRNVQFEDVLGVLQER 92


>UniRef50_Q46AJ8 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Methanosarcinaceae
           RepID=HIS2_METBF
          Length = 104

 Score = 91.1 bits (225), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 33/98 (33%), Positives = 52/98 (53%), Gaps = 2/98 (2%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHD 165
                  L ++ +++ +RK    E SY  KL     G  +I +KVGEE +ET LA    +
Sbjct: 2   PDADLSILNRVYEIILDRKQNYDERSYVCKLLNHRKGMNKILEKVGEESIETILAVRNEN 61

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             E+ +E+SDL++HLLV+L    + L  +   L  RH+
Sbjct: 62  HEEIVSESSDLIFHLLVMLAANNVTLDEIAAELSARHE 99


>UniRef50_B3WEC9 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Lactobacillus casei
           group RepID=HIS2_LACCB
          Length = 110

 Score = 91.1 bits (225), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 29/90 (32%), Positives = 45/90 (50%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             +  L   + ER++     SYT  L+  G  +I +KVGEE  E  +AA   D      E
Sbjct: 6   QSIPALYDFIKERQANPVAGSYTDYLFTKGLDKILKKVGEESTEVIVAAKNPDDPAFILE 65

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL YH+LVL+ ++G+ +  +   L  R 
Sbjct: 66  VADLTYHVLVLMVERGITVDQIATELASRE 95


>UniRef50_Q0W1M3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=uncultured methanogenic
           archaeon RC-I RepID=HIS2_UNCMA
          Length = 95

 Score = 91.1 bits (225), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 2/93 (2%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELT 170
             L ++  ++A+RK    E SYT  LY    G  ++ +K+GEE  E  +AA      E+ 
Sbjct: 3   DVLDEVYAVIADRKVNPKEGSYTTSLYNHRKGIDKVLEKIGEESTELIIAAKNGGEKEIV 62

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           +E +DL +H +VLL  + +    + E   +R +
Sbjct: 63  SECADLFFHAMVLLAAKDIPFEKIKEEFERRRK 95


>UniRef50_B1JUA7 Phosphoribosyl-ATP pyrophosphatase n=72 Tax=Proteobacteria
           RepID=HIS2_BURCC
          Length = 121

 Score = 90.7 bits (224), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 31/94 (32%), Positives = 45/94 (47%), Gaps = 4/94 (4%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV----HDRFE 168
             L +L  ++  RK  DP+ SY ++L+  G   + +K+GEE  E  LAA           
Sbjct: 7   DTLLRLAAVIDSRKGGDPDQSYVSRLFHKGDDAVLKKIGEEATEVVLAAKDVRQGGAPTA 66

Query: 169 LTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           L  E +DL +H LV+L    L    VI  L +R 
Sbjct: 67  LVGEVADLWFHCLVMLSHFDLSPADVIAELERRE 100


>UniRef50_B2S985 Phosphoribosyl-ATP pyrophosphatase n=57 Tax=Alphaproteobacteria
           RepID=HIS2_BRUA1
          Length = 107

 Score = 90.7 bits (224), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  LE+++AER S    TSYTA L A G  + AQK+GEE VET +AA   DR  +
Sbjct: 1   MSQFTLADLERIVAERASVTDGTSYTASLVAKGQPKAAQKLGEEAVETVIAAVSGDRAGV 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +E++DL+YHL V+    G+ L  V++ L++R
Sbjct: 61  VSESADLLYHLAVVWNIAGVALEDVLQELQRR 92


>UniRef50_Q0S4J7 Putative uncharacterized protein n=4 Tax=Nocardiaceae
           RepID=Q0S4J7_RHOSR
          Length = 288

 Score = 90.4 bits (223), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 23/134 (17%), Positives = 43/134 (32%), Gaps = 7/134 (5%)

Query: 72  LNVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPE 131
             V ++  +     +LV  +P  PT           +          + L+   +  D  
Sbjct: 34  QGVRTLLTEAPGAAVLVSTDPDHPT---VREWVASGSRVIAAPKVPGDNLVEAAEVMDRL 90

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQ 187
            SY         + ++  + EE  E   A    +R +L  E  DL    ++H  +     
Sbjct: 91  WSYGGWEVTQTHRTLSHYLVEETYEVLDAIESSERADLREELGDLLLQVLFHSRIASASG 150

Query: 188 GLDLTTVIENLRKR 201
             D+  V   L  +
Sbjct: 151 HFDVDDVAATLVAK 164


>UniRef50_A0LCF5 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Proteobacteria
           RepID=HIS2_MAGSM
          Length = 252

 Score = 88.0 bits (217), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 38/99 (38%), Positives = 51/99 (51%), Gaps = 2/99 (2%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSAD-PETSYTAKLYASGTKRIAQKVGEEGVETALAAT- 162
                     L Q+ Q++ +RKSA  PE SY AKL+  G   I +KVGEE  E  LA   
Sbjct: 3   NLSPPSTVDILEQVYQVIQQRKSAPDPEASYVAKLFHKGDDAILKKVGEEATELVLAIKG 62

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
              R E+ +EA+DL++H LV L    +  T V+  L  R
Sbjct: 63  RAARNEVAHEAADLIFHTLVGLAIMNIPPTEVMNVLSSR 101


>UniRef50_A5CXC6 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=sulfur-oxidizing
           symbionts RepID=HIS2_VESOH
          Length = 105

 Score = 86.9 bits (214), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 31/89 (34%), Positives = 49/89 (55%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +LEQ+L +RKSA  + SY + LY  GT  I +K+ EE  E  +A       ++  E
Sbjct: 3   EILIKLEQILEQRKSAKADKSYVSSLYNKGTDEILKKISEESAEVIMATKDGSNDKIIYE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +DL +H LVLL+ + + +  +   L +R
Sbjct: 63  IADLWFHTLVLLRFKKIKVEQITNELSRR 91


>UniRef50_Q938W0 Phosphoribosyl-ATP pyrophosphatase 2 n=11 Tax=Bradyrhizobiaceae
           RepID=HIS22_BRAJA
          Length = 134

 Score = 86.9 bits (214), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 27/90 (30%), Positives = 46/90 (51%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L   +   +  DP TS TA+L+  G  ++A+K+ EE +E  + A   D   +  E
Sbjct: 3   DSLERLYLAVLAARDLDPATSRTARLFQRGPSKMAKKLAEEAIEVVIDAVNGDTDAVVRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++DL+Y+L VL    G+    V   + +R 
Sbjct: 63  SADLLYNLTVLWASAGVRPEDVWREMTRRE 92


>UniRef50_Q2FUB9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Methanospirillum
           hungatei JF-1 RepID=Q2FUB9_METHJ
          Length = 91

 Score = 86.9 bits (214), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 50/90 (55%), Gaps = 2/90 (2%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYA--SGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + ++  ++ ER +   E SYT+K+     G  +  +K+GEE  E  +A    D+  ++ E
Sbjct: 1   MDEIWAVIEERAAHPSEESYTSKILTHSKGIDKSLEKIGEECTEFIIAVKNGDKNRISEE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +DL++H ++ L+  G+ L +V + L+ R 
Sbjct: 61  GADLLFHFMLALKRSGVTLQSVWDELQSRR 90


>UniRef50_Q2CDY7 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Rhodobacteraceae
           RepID=Q2CDY7_9RHOB
          Length = 106

 Score = 85.7 bits (211), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 36/89 (40%), Positives = 53/89 (59%), Gaps = 1/89 (1%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           + L  L + +A RK ADP+ S+TA+L AS  +  A+K GEE VE  + A   DR  L +E
Sbjct: 1   MSLAALAETIARRKGADPDKSWTARLLAS-PEMAAEKFGEEAVEAIIEAVKGDRDRLVSE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
           A+D++YHLLV+     + L  +   L +R
Sbjct: 60  AADVIYHLLVMCAVNDITLADIERELERR 88


>UniRef50_Q11CK6 Phosphoribosyl-ATP pyrophosphatase n=4 Tax=Rhizobiales
           RepID=HIS2_MESSB
          Length = 112

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 36/92 (39%), Positives = 57/92 (61%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE ++AER ++    S+TA+L ++G  + A+K+GEE VET +AA   D+  L
Sbjct: 1   MNEFDLSRLEGIIAERANSGDTQSWTARLISAGMDKAAKKLGEEAVETVIAAVARDKKAL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             E++DL+YH LV+L+  G+ L  V+  L  R
Sbjct: 61  IAESADLVYHWLVVLKIAGVRLDEVMLELESR 92


>UniRef50_Q1GQI3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Sphingopyxis alaskensis
           RepID=HIS2_SPHAL
          Length = 109

 Score = 85.3 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 34/74 (45%), Positives = 45/74 (60%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           + E SY A L A G  +IAQK+GEE VE  +AA   D   L  EASDL++HL +LL ++G
Sbjct: 24  EAEASYVASLAAKGRGKIAQKLGEEAVEAVIAAVSEDDPALIGEASDLVFHLSILLAERG 83

Query: 189 LDLTTVIENLRKRH 202
           L    +   L +RH
Sbjct: 84  LTWDAIAAELDRRH 97


>UniRef50_A3VQS9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Parvularcula bermudensis
           HTCC2503 RepID=A3VQS9_9PROT
          Length = 109

 Score = 85.0 bits (209), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 38/89 (42%), Positives = 48/89 (53%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            L +L   +  RK AD   SYTA L   G  R A+K GEE VE ALA  +  R +L  E 
Sbjct: 7   TLERLMTTIEGRKGADAGDSYTASLLRKGPVRCAKKFGEEAVEAALAGALGQREDLVAET 66

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +D++YHL VLL    LD + +   L KR 
Sbjct: 67  ADVLYHLAVLLAANELDWSDISAALTKRE 95


>UniRef50_A8TJZ9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TJZ9_9PROT
          Length = 104

 Score = 85.0 bits (209), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 50/91 (54%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             + +L + +   ++  P  S TA+L   G  +IA+KV EE  E AL A V DR  +  E
Sbjct: 3   HPIDRLYRGVHLARAESPGESRTAQLLRDGNPKIAKKVVEEAAEVALDAVVSDRDGVIRE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           ++DL+Y+L+VL    G+  + V   + +R +
Sbjct: 63  SADLLYNLMVLWVWMGITPSEVWAEMEQREK 93


>UniRef50_B4UDK1 Phosphoribosyl-ATP diphosphatase n=1 Tax=Anaeromyxobacter sp. K
           RepID=B4UDK1_ANASK
          Length = 110

 Score = 84.2 bits (207), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 6/90 (6%)

Query: 118 LEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNE 172
              + + R  A P  SYT KL A    RI +K+ EE  E   A          +  L +E
Sbjct: 11  WATIESRRADAAPAESYTKKLLA-APARIRRKIIEEAYEVNEAHQALLDGKDTKDHLAHE 69

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           A+DL+YHL VLL    +  T V   L +RH
Sbjct: 70  AADLLYHLYVLLASADVTPTEVYGVLERRH 99


>UniRef50_A4SV22 Phosphoribosyl-ATP pyrophosphohydrolase n=3 Tax=Burkholderiaceae
           RepID=A4SV22_POLSQ
          Length = 133

 Score = 84.2 bits (207), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 8/83 (9%)

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV--------HDRFELTNEASDLMY 178
           SADP+TSYTA L++ G   I +K+GEE  E  +AA            +  L  E +DL +
Sbjct: 33  SADPKTSYTALLFSKGDDGILKKIGEEATEAVMAAKDARNSNLAAEQQKLLIGEMADLWF 92

Query: 179 HLLVLLQDQGLDLTTVIENLRKR 201
           H L+ L    L    VI  L +R
Sbjct: 93  HCLIALSQFNLRPEDVIAELDRR 115


>UniRef50_Q3IU57 Phosphoribosyl-ATP pyrophosphatase n=9 Tax=Halobacteriaceae
           RepID=HIS2_NATPD
          Length = 101

 Score = 83.4 bits (205), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 37/96 (38%), Positives = 54/96 (56%), Gaps = 2/96 (2%)

Query: 109 AHQWLFLYQLEQLLAERKSADPETSYTAKLY--ASGTKRIAQKVGEEGVETALAATVHDR 166
                 L +L +++  RK   P+ SYTA L+    G   + +K+GEE  E  LAA   D 
Sbjct: 6   HDGDEVLDELFEVIESRKEELPDGSYTASLFTHEKGENAVLEKLGEETTELLLAAKDDDD 65

Query: 167 FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            EL +EA+D++YHLLVLL  + ++L  +   LRKR 
Sbjct: 66  EELAHEAADIVYHLLVLLSMKDMELADLRAELRKRR 101


>UniRef50_B8FZC0 MazG family protein n=5 Tax=Bacteria RepID=B8FZC0_DESHD
          Length = 493

 Score = 81.9 bits (201), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
                 +   + EE  E   A    D + L  E  DL+    +H  V  +        V 
Sbjct: 249 EQTHDSLKPYLIEESYEVLEAIEAQDMYNLAEELGDLLLQVVFHAQVAQEAGEFQFQDVL 308

Query: 195 ---IENLRKRH 202
              I+ + +RH
Sbjct: 309 KGIIDKMIRRH 319


>UniRef50_A6UTD9 Phosphoribosyl-ATP pyrophosphatase n=13 Tax=Euryarchaeota
           RepID=HIS2_META3
          Length = 96

 Score = 81.5 bits (200), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 33/96 (34%), Positives = 54/96 (56%), Gaps = 4/96 (4%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASG----TKRIAQKVGEEGVETALAATVHDRF 167
              L +  +++ +R    PE SY A L  +       +I +KVGEE  ET LAA   D+ 
Sbjct: 1   MDILKEEFEIIKQRIKDKPEGSYVAYLTTADKKTPINKICEKVGEEATETILAAKDQDKQ 60

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           EL  E++DL++H+LVLL + G++   ++E   +R +
Sbjct: 61  ELIYESADLIFHILVLLANNGIEYEELMEEFERRRK 96


>UniRef50_Q3AFK8 Tetrapyrrole methylase family protein/MazG family protein n=6
           Tax=Bacteria RepID=Q3AFK8_CARHZ
          Length = 479

 Score = 80.7 bits (198), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   V EE  E A A    D  +L  E  DL+    +H  +  ++       V+
Sbjct: 252 EQTHRSLLPYVLEEAYEVAEAIEEEDPEKLKEELGDLLLQVVFHAQIAREEGEFTFKEVV 311

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 312 EGICEKLIRRH 322


>UniRef50_B2A3P2 MazG family protein n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF
           RepID=B2A3P2_NATTJ
          Length = 384

 Score = 80.3 bits (197), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    +   +  E  DL+    +H  V  +     L  V+
Sbjct: 133 KQTHQTLKPYLIEEAYEVIEAIHEQNPDSVCEELGDLLLQVIFHAQVAEEQGEFQLDEVL 192

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 193 TKLKDKLITRH 203



 Score = 41.8 bits (97), Expect = 0.016,   Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 26/60 (43%), Gaps = 4/60 (6%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ----DQGLDLTTVIENLRKRHQ 203
           +KV EE  E   A    +  +L  E  D+++ L+ L +       + L    E  R+R +
Sbjct: 292 EKVNEEFTELQDAYQQENWEKLEEEIGDIIFSLVNLARFFNISTEVSLERTNEKFRRRFR 351


>UniRef50_A5D640 Conserved protein n=12 Tax=Bacteria RepID=A5D640_PELTS
          Length = 582

 Score = 80.0 bits (196), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D ++   E  DL+    +H  +  +++  D+  VI
Sbjct: 345 EQDHRTLKPYLLEEAYEVIEALDEEDMYKTCEELGDLLLQIVFHAQIAAENRHFDINDVI 404

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 405 AGISEKMIRRH 415


>UniRef50_B4U6I7 MazG family protein n=1 Tax=Hydrogenobaculum sp. Y04AAS1
           RepID=B4U6I7_HYDS0
          Length = 251

 Score = 80.0 bits (196), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 32/71 (45%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
               + +A+ V EE  E   A    D+  +  E +DL+    +H  +  +++  D+  V 
Sbjct: 24  KQTHESLAKYVLEEAYELVDAIDSKDKEAIKEELADLLLQIVFHAQIAKENKEFDINDVF 83

Query: 195 ---IENLRKRH 202
              I+ L +RH
Sbjct: 84  ELLIKKLVERH 94


>UniRef50_C0GIZ4 MazG family protein n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GIZ4_9FIRM
          Length = 481

 Score = 80.0 bits (196), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D  +L  E  DL+    +H  +  ++Q      ++
Sbjct: 250 EQDHHSLKPYLLEEAYEVIGAIDSGDNDDLCEELGDLLLQVVFHCQIANENQAFAFHDIV 309

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 310 AGITEKLVRRH 320



 Score = 41.4 bits (96), Expect = 0.016,   Method: Composition-based stats.
 Identities = 10/55 (18%), Positives = 21/55 (38%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
             +    K+ EE  E   A    D  ++  E  DL++  + + +   +D    + 
Sbjct: 382 DAQGAWDKLAEELKELKDAYKEQDGAKIKEEMGDLLFAAVNVARFLDVDAEQALA 436


>UniRef50_C9RQ70 Phosphoribosyl-ATP diphosphatase n=1 Tax=Fibrobacter succinogenes
           subsp. succinogenes S85 RepID=C9RQ70_FIBSS
          Length = 86

 Score = 79.6 bits (195), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 25/86 (29%), Positives = 43/86 (50%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
           +   ++  L  +RK   PE   T +L+  G   I +K+ EE  E+ +AA    R     E
Sbjct: 1   MTFEEMYALACQRKKDMPEGKGTTELFKKGPHGIGKKLVEEAAESWMAARFESRDAQCLE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S ++Y++ V++ ++GL L  V   L
Sbjct: 61  LSQVLYYVAVMMAEKGLTLEEVYAKL 86


>UniRef50_Q4JVP0 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Bacteria
           RepID=Q4JVP0_CORJK
          Length = 332

 Score = 79.2 bits (194), Expect = 8e-14,   Method: Composition-based stats.
 Identities = 27/91 (29%), Positives = 38/91 (41%)

Query: 108 TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRF 167
              +      L   L+ R    PE S T K   +G     +K+ EE  E  LAA      
Sbjct: 242 NEQELKTFDSLFAELSSRAKERPEGSGTVKALDAGVHFQGKKIVEEAGEVWLAAEYESDE 301

Query: 168 ELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
           EL  E S L+Y L V++  +GL    + + L
Sbjct: 302 ELAEEISQLLYWLQVVMVGRGLTPADIYKYL 332


>UniRef50_Q9EWK0 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Streptomyces
           RepID=HIS2_STRCO
          Length = 90

 Score = 78.8 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 26/76 (34%), Positives = 39/76 (51%)

Query: 123 AERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLV 182
            +  + DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V
Sbjct: 15  HKAANGDPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKDAAAEEISQLLYHVQV 74

Query: 183 LLQDQGLDLTTVIENL 198
           ++  +G+ L  V  +L
Sbjct: 75  MMVARGISLDDVYAHL 90


>UniRef50_A2CDV8 MazG family protein n=11 Tax=Cyanobacteria RepID=A2CDV8_PROM3
          Length = 332

 Score = 78.8 bits (193), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +   + EE  E A A    D   L+ E  DL+     H  +  ++   +L  +
Sbjct: 87  LEQTHTSLIPCMLEEAHEVADAIRNGDDNHLSEELGDLLLQVVLHAQIANEEGRFNLEDI 146

Query: 195 IE----NLRKRH 202
                  L +RH
Sbjct: 147 ARSISAKLIRRH 158



 Score = 43.7 bits (102), Expect = 0.003,   Method: Composition-based stats.
 Identities = 12/53 (22%), Positives = 22/53 (41%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193
           +    +  KV EE  E   A    D+     E  D+++ L+ + +  GL+   
Sbjct: 226 NTIDGVWGKVQEEFEELKEAVEHEDQAHAQTELGDVLFTLVNVARWCGLNPEE 278


>UniRef50_Q1V186 Phosphoribosyl-ATP diphosphatase n=3 Tax=root RepID=Q1V186_PELUB
          Length = 101

 Score = 78.4 bits (192), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 27/91 (29%), Positives = 47/91 (51%), Gaps = 2/91 (2%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  L   + +RK+ D + SYT+ L + G  +   K+ EE  E   A   +D+  + +E
Sbjct: 3   ENLLNLVNTIRDRKNKDEDKSYTSSLLSGGLSKCIDKMEEEFDELKEAL--NDKSNIVHE 60

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D +YH+LV L+   +    V++ L  R +
Sbjct: 61  AADTIYHILVTLEAADIKFEDVLKELEGRKK 91


>UniRef50_B3DW98 Predicted pyrophosphatase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DW98_METI4
          Length = 269

 Score = 78.0 bits (191), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               K +  ++ EE  E   A    D   +  E  D    +++H  +  +        ++
Sbjct: 41  EQTHKSLKSQLIEECYELLEAIDQEDPSSIKEELGDILLHVLFHAQIAQEAGKFSFWDIL 100

Query: 196 ----ENLRKRH 202
                 L +RH
Sbjct: 101 DNLSAKLIRRH 111



 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 23/57 (40%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
              +    K+ EE  E   A    +R ++  E  DL++  +   +  G+D    I+ 
Sbjct: 173 KDPQGPLSKMQEELDEIKEAYGEKNREKIKKEIGDLIFSAVNFSRMLGIDPEEAIKE 229


>UniRef50_B1W4A6 Phosphoribosyl-ATP pyrophosphatase n=11 Tax=Actinomycetales
           RepID=HIS2_STRGG
          Length = 90

 Score = 77.6 bits (190), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 26/70 (37%), Positives = 37/70 (52%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQG 188
           DP TS TA+L   G   I +KV EE  E  +AA    +     E S L+YH+ V++  +G
Sbjct: 21  DPATSRTAELVDKGVHAIGKKVVEEAAEVWMAAEYEGKEAAAEEISQLLYHVQVMMVARG 80

Query: 189 LDLTTVIENL 198
           + L  V  +L
Sbjct: 81  ISLDDVYAHL 90


>UniRef50_C9RLE1 MazG family protein n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RLE1_FIBSS
          Length = 265

 Score = 77.6 bits (190), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
              T  +   + EE  E   AA   D+  +  E  D++    +H  V  +     +  VI
Sbjct: 26  QQTTHSLLPYLVEESCEFIDAAQDGDKEHMCEELGDVLFQVIFHSQVCKEQGDFTIEDVI 85

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 86  QGLCEKMVRRH 96


>UniRef50_C9RA19 MazG family protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RA19_AMMDK
          Length = 495

 Score = 77.6 bits (190), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 14/73 (19%), Positives = 25/73 (34%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAAT--VHDRFELTNEASDLM----YHLLVLLQDQGLDLTT 193
               + + + + EE  E   A      D   L  E  DL+    +H  +  +    +L  
Sbjct: 256 EQTHQSLKKYLLEETYEVLEAIDRVEEDPHNLCEELGDLLLQIVFHCQIAAEAGRFNLDD 315

Query: 194 VI----ENLRKRH 202
           V+      +  RH
Sbjct: 316 VVRSITRKMIARH 328


>UniRef50_C8XKR8 MazG family protein n=3 Tax=Actinomycetales RepID=C8XKR8_NAKMY
          Length = 240

 Score = 77.6 bits (190), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 15/75 (20%), Positives = 26/75 (34%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQ----DQGLDL 191
                 + + + EE  E   A    DR  +  E  D    +++H  +  +      G D+
Sbjct: 34  EQTHASLVRYLLEECYELVEAVESGDRAAIREELGDVLLQVLFHARIAAETPRDQGGFDI 93

Query: 192 TTVI----ENLRKRH 202
             V       L +RH
Sbjct: 94  DDVAGDLVAKLVRRH 108


>UniRef50_Q0C645 Phosphoribosyl-ATP diphosphatase n=2 Tax=Hyphomonadaceae
           RepID=Q0C645_HYPNA
          Length = 120

 Score = 77.3 bits (189), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 31/100 (31%), Positives = 44/100 (44%)

Query: 103 SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
                        +  E + A     D  +S+TAKL A G    A KV EEG E A A  
Sbjct: 6   PLASPDRLAAALAHLAETIDARALDGDASSSWTAKLLAKGPDAAAAKVAEEGGELADAVR 65

Query: 163 VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
                 + +EA+D++YH+ V L+ +G+ L  V   L  R 
Sbjct: 66  RESDDRVASEAADVIYHVFVALRSRGVALDAVAGALEARQ 105


>UniRef50_C2D9Q9 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D9Q9_9ACTN
          Length = 336

 Score = 77.3 bits (189), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 19/71 (26%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTV- 194
           A   + I + + EE  E   A    D   L  E  D    ++ H  + L +Q   L  V 
Sbjct: 55  AQTHESITKNMIEEAYEAVDAIHQADSEHLCEELGDVLEQVLLHAQIALDNQEFTLEDVC 114

Query: 195 ---IENLRKRH 202
               E L +RH
Sbjct: 115 HGLAEKLIRRH 125


>UniRef50_A6DH39 Tetrapyrrole (Corrin/Porphyrin) methylase and MazG nucleotide
           pyrophosphohydrolase domain fusion protein n=1
           Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH39_9BACT
          Length = 258

 Score = 76.9 bits (188), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A    D  EL +E  DL+    +H  +  +++   +  V 
Sbjct: 27  EQDHDTLKKYLIEECSEVLDAIDNKDPDELKDELGDLLMNIFFHAQIAQENKQFSIHDVA 86

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 87  QNISEKMIRRH 97


>UniRef50_C5CGC7 MazG family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CGC7_KOSOT
          Length = 256

 Score = 76.9 bits (188), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    +  E   E  DL+    +H  +  +     +  V+
Sbjct: 28  EQTHESLKPYLIEEAYEVLAAIDKGNDEEFAEELGDLLLQIIFHSQIASERNAFTIDDVV 87

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 88  ETLSDKLIRRH 98



 Score = 42.2 bits (98), Expect = 0.009,   Method: Composition-based stats.
 Identities = 12/52 (23%), Positives = 24/52 (46%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
              + + +KV EE  E   A    D+ ++  E  DL++ ++ L +   +D  
Sbjct: 157 ENLEDVTEKVEEEWSELMNAIKSGDKKKINEEFGDLLFSMVNLSRFIEVDPE 208


>UniRef50_C9XSA1 Putative bifunctional protein [include tetrapyrrole
           (Corrin/Porphyrin) methylase and nucleoside triphosphate
           pyrophosphohydrolase] n=7 Tax=Clostridium
           RepID=C9XSA1_CLODC
          Length = 491

 Score = 76.5 bits (187), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   V EE  E   A   +D  E+  E  D++    +H  +  ++   DL  V+
Sbjct: 261 KQTHQSLKNSVIEEAYELCNAIDNNDIDEMVEELGDVLLQVIFHCQIGNEEGYFDLKEVV 320

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 321 NGICKKLIHRH 331


>UniRef50_Q1PZU0 Conserved hypthetical protein n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1PZU0_9BACT
          Length = 283

 Score = 76.5 bits (187), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A       +L  E +DL    ++H  +  + +  D+  V+
Sbjct: 47  EQNHVTLKPYLVEETYEVIDAIDSGIPDKLKEELADLFLQIIFHCQIAREKKEFDINDVM 106

Query: 196 ----ENLRKRH 202
               + + +RH
Sbjct: 107 KLCLDKMMRRH 117


>UniRef50_D1C338 MazG family protein n=1 Tax=Sphaerobacter thermophilus DSM 20745
           RepID=D1C338_SPHTD
          Length = 466

 Score = 76.5 bits (187), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + +   EE  E   A    D   L  E  DL+     H  +  +     L  VI
Sbjct: 260 EQTHQSLMRAGIEEAYEVLEAIERDDAAALREELGDLLLQVYLHAQIAEEAGEFTLEDVI 319

Query: 196 ----ENLRKRH 202
                 L +RH
Sbjct: 320 GDLSAKLVRRH 330


>UniRef50_Q47SV3 MazG, bacterial n=1 Tax=Thermobifida fusca YX RepID=Q47SV3_THEFY
          Length = 246

 Score = 76.1 bits (186), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 22/107 (20%), Positives = 38/107 (35%), Gaps = 16/107 (14%)

Query: 106 GDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD 165
            +   Q   L  L +++   +   P  S          + +A+ + EE  ET       D
Sbjct: 4   HNGTPQGHRLIALVEVMDTLRRECPWDS------EQTHESLAKYLIEEAYETVETIERGD 57

Query: 166 RFELTNEASDLM----YHLLVLLQDQ--GLDLTTV----IENLRKRH 202
              L  E  D++    +H  V  +    G  +  V    I+ L +RH
Sbjct: 58  YDTLAEELGDVLLQVVFHARVAAERGPDGFTIDDVADAIIDKLVRRH 104


>UniRef50_UPI0001C36472 MazG family protein n=1 Tax=Clostridium hathewayi DSM 13479
           RepID=UPI0001C36472
          Length = 162

 Score = 76.1 bits (186), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 18/121 (14%), Positives = 37/121 (30%), Gaps = 16/121 (13%)

Query: 91  NPIGPTCHKGTSSCFGD-TAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQK 149
            P G   H          + + +  L ++   L        +            + +   
Sbjct: 18  GPDGAAAHPARIFVKRGISMYSFEDLVRITAELRSEHGCPWDR-------KQTHESLKPC 70

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVI----ENLRKR 201
           + EE  E   A    D   L  E  D+++    H  +  ++    +  V+    E + +R
Sbjct: 71  LKEESEEVLAAIDNQDMENLCEELGDVLFQVLIHSRIAEENGAFTVADVVNGICEKMVRR 130

Query: 202 H 202
           H
Sbjct: 131 H 131


>UniRef50_Q898L3 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Clostridium tetani
           RepID=HIS2_CLOTE
          Length = 107

 Score = 75.7 bits (185), Expect = 9e-13,   Method: Composition-based stats.
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
            +   L +    + + +  D   SY   L+   + +I +K+GE+  E  +A     + E 
Sbjct: 1   MEVNKLIEELVEVIKDRKNDIIFSY---LFEEESDKILKKIGEKSSEVIIACKNASKEEQ 57

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            +E SDL+Y+L+VL+  Q +++  VIE L KR 
Sbjct: 58  VHEISDLIYNLMVLMMKQNIEIENVIEELGKRR 90


>UniRef50_A6LPK0 MazG family protein n=10 Tax=Clostridia RepID=A6LPK0_CLOB8
          Length = 483

 Score = 75.7 bits (185), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               K + + + EE  E   A    D   L  E  D++    +H  +  +D   D+  VI
Sbjct: 250 EQTHKSLKKALIEESYEVIDAIDQDDDNSLIEELGDVLLQVVFHASIGKEDGYFDIGDVI 309

Query: 196 E----NLRKRH 202
           E     +  RH
Sbjct: 310 EGICNKMISRH 320


>UniRef50_B0SCK2 Pyrophosphatase n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SCK2_LEPBA
          Length = 290

 Score = 75.7 bits (185), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E        D   L  E  DL+    +H  +  +    D   V 
Sbjct: 31  EQTHRSVIPHLLEETYEVVDTIEKGDDNHLKEELGDLLFQITFHSQLAKERGAFDFQDVA 90

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 91  SGVFQKLVYRH 101


>UniRef50_B6BRN9 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Candidatus
           Pelagibacter sp. HTCC7211 RepID=B6BRN9_9RICK
          Length = 90

 Score = 75.3 bits (184), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 3/91 (3%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L  L +L  +RKS+  E SYT KL          KV EE  E   A   +      +E
Sbjct: 3   NTLENLIKLARDRKSSPVEGSYTNKLLT-DKSLSKAKVLEEVNELIEAVEENSNK--IHE 59

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           A+D+ YHLL+ L+   + +  V++ L  R +
Sbjct: 60  AADVFYHLLMYLEANDVKIEEVMQELENRKK 90


>UniRef50_Q7V9I6 Predicted pyrophosphatase n=1 Tax=Prochlorococcus marinus
           RepID=Q7V9I6_PROMA
          Length = 276

 Score = 75.3 bits (184), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 12/72 (16%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +     EE  E   A    +  +L  E  DL+     H  +  +++      +
Sbjct: 34  LKQNHTSLIPYAIEEAYEVCDAIRYGNDSDLIEELGDLLLQVVLHAQIANEEKRFCFDDI 93

Query: 195 ----IENLRKRH 202
                E + +RH
Sbjct: 94  AQTAAEKMIRRH 105


>UniRef50_B8ZRE4 Phosphoribosyl-ATP pyrophosphatase n=107 Tax=Bacteria
           RepID=HIS2_MYCLB
          Length = 93

 Score = 75.3 bits (184), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 27/86 (31%), Positives = 35/86 (40%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
                L   L+ER    P  S T      G   + +K+ EE  E  LAA    +  L  E
Sbjct: 8   KTFEDLFAELSERARTRPTDSATVASLDGGIHALGKKILEEAGEVWLAAEHEPKEVLAEE 67

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENL 198
            S L+Y   VL+  +GL L  V   L
Sbjct: 68  ISQLLYWTQVLMISRGLSLDDVYRKL 93


>UniRef50_C1ZIN5 Phosphoribosyl-ATP pyrophosphohydrolase n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZIN5_PLALI
          Length = 98

 Score = 75.3 bits (184), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 3/90 (3%)

Query: 115 LYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELTN 171
           L +LE  L  R    P  SY  +L  +G   +A  + E+  +   A    D     ++  
Sbjct: 5   LKRLEAQLEHRLKELPAGSYVTELSQAGHHMMATTLVEKAYQMVEACAEEDAGNPGDVPA 64

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            A+++++H ++LL+  G DL+TV   L +R
Sbjct: 65  AAANVLFHWMLLLKAYGHDLSTVERELMQR 94


>UniRef50_P37556 Uncharacterized protein yabN n=95 Tax=Bacillaceae RepID=YABN_BACSU
          Length = 489

 Score = 74.9 bits (183), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               + + Q + EE  E   A    D   +  E  D    ++ H  +   +    +  VI
Sbjct: 254 KQTHQSLKQYMIEECYELLEAIDEEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVI 313

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 314 KGISEKMVRRH 324


>UniRef50_Q7D8Z6 Transcriptional regulator, MazG family n=3 Tax=Mycobacterium
           RepID=Q7D8Z6_MYCTU
          Length = 294

 Score = 74.9 bits (183), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 19/126 (15%), Positives = 41/126 (32%), Gaps = 16/126 (12%)

Query: 86  LLVLANPIGPTC----HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYAS 141
           +L+ ++P  P        G        + +   L     ++ + ++A P  S        
Sbjct: 23  VLLSSDPNHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWES------EQ 76

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQG--LDLTTVI 195
               + + + EE  E   A       +L  E  DL    ++H  +          +  V 
Sbjct: 77  THDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVA 136

Query: 196 ENLRKR 201
           + L ++
Sbjct: 137 DTLMRK 142


>UniRef50_Q6G3M6 MazG protein n=1 Tax=Bartonella henselae RepID=Q6G3M6_BARHE
          Length = 273

 Score = 74.9 bits (183), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 15/82 (18%), Positives = 28/82 (34%), Gaps = 8/82 (9%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLL 184
               S          + +   + EE  E   A    +R +L +E  DL+    YH  +  
Sbjct: 18  RNRESGCIWNIKQTFESLIPYMLEEVYEVIDAIERKNRTDLCDELGDLLLQVVYHATIAQ 77

Query: 185 QDQGLDLTTVI----ENLRKRH 202
           ++       V+      + +RH
Sbjct: 78  EEGSFTFEDVVYAITSKMIRRH 99


>UniRef50_B2TI15 MazG family protein n=5 Tax=Clostridium RepID=B2TI15_CLOBB
          Length = 488

 Score = 74.9 bits (183), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I   + EE  E   A    D   L  E  D++    +H  +  +D   ++  V+
Sbjct: 250 EQTHESIKNSLIEESYEVVDAINNEDDDSLIEELGDVLFQVVFHSSIGQEDGYFNINDVV 309

Query: 196 ----ENLRKRH 202
               + +  RH
Sbjct: 310 KAICDKMIYRH 320



 Score = 40.3 bits (93), Expect = 0.039,   Method: Composition-based stats.
 Identities = 13/65 (20%), Positives = 25/65 (38%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTV----IE 196
                  +KV EE  E   A    ++ ++ +E  DL++  + + +  G+D        I 
Sbjct: 385 DDVSFAFEKVNEELKEVKDAYISENKEKIEDEIGDLLFSCVNVARFLGIDGEEALNSTIN 444

Query: 197 NLRKR 201
               R
Sbjct: 445 KFISR 449


>UniRef50_A0QBX2 Transcriptional regulator, MazG family protein n=22
           Tax=Mycobacterium RepID=A0QBX2_MYCA1
          Length = 334

 Score = 74.6 bits (182), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 23/138 (16%), Positives = 46/138 (33%), Gaps = 17/138 (12%)

Query: 74  VVSIAPDCDNDTLLVLANPIGPTCHK----GTSSCFGDTAHQWLFLYQLEQLLAERKSAD 129
           V S  PD D   +L+ ++   P        G        A +   L     ++ + ++A 
Sbjct: 46  VHSGDPD-DPAPVLLSSDRDHPAVTARLAAGARLISAPDAPRGERLVDAVAMMDKLRTAG 104

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQ 185
           P  S          + + + + EE  E   A    +   L +E  D    +++H  +   
Sbjct: 105 PWES------EQTHESLRRFLLEETYELLDAVAGGNAEALRDELGDVLLQVLFHARIAED 158

Query: 186 D--QGLDLTTVIENLRKR 201
                  +  V   L ++
Sbjct: 159 APQSAFTIDDVAAALIRK 176


>UniRef50_D2LXK4 MazG family protein n=2 Tax=Bacillus RepID=D2LXK4_BACS4
          Length = 494

 Score = 74.6 bits (182), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + + EE  E   A    +  +L  E  D++     H  +   +    +  VI
Sbjct: 254 EQTHESLKKYLIEEAYEVLDAIDKGNEDDLVEELGDVLLQVVLHSQIGEDNGIFSIDQVI 313

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 314 ETLTEKMIRRH 324



 Score = 41.1 bits (95), Expect = 0.022,   Method: Composition-based stats.
 Identities = 8/56 (14%), Positives = 21/56 (37%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
                +  K+ EE  E         + + + E  D+++  + + +  G+D    + 
Sbjct: 392 GDEAPMWMKLQEEIAEWFQELKEGTKQDASKELGDVLFAFVNIARFHGIDPEEALR 447


>UniRef50_D0RQN9 Phosphoribosyl-ATP diphosphatase n=1 Tax=alpha proteobacterium
           HIMB114 RepID=D0RQN9_9RICK
          Length = 103

 Score = 74.6 bits (182), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 3/91 (3%)

Query: 112 WLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTN 171
           +  L  L + + ERK++    SYT KL  +      +KV EE  E   A   +++    +
Sbjct: 2   FEVLEGLIKTIRERKNSSEHESYTKKLLDNN-SLCREKVMEEIKELVEAL--NEKKNEVH 58

Query: 172 EASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           EA+D+MYH+LVLL+   + +  V+  L+KR 
Sbjct: 59  EAADVMYHILVLLEANNVKVEDVMNELKKRE 89


>UniRef50_A5WC40 MazG family protein n=4 Tax=Moraxellaceae RepID=A5WC40_PSYWF
          Length = 289

 Score = 74.2 bits (181), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +     EE  E A A    D  ++  E  D++    +H  +  + Q  DL  V
Sbjct: 46  IKQTNHSLIPYAIEEAYELAEAIQEGDIEDIKGELGDVLLQVVFHCQIYAEQQQFDLGDV 105

Query: 195 I----ENLRKRH 202
           I      L +RH
Sbjct: 106 IYTLQSKLIRRH 117


>UniRef50_C7NET9 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Kytococcus sedentarius DSM 20547
           RepID=C7NET9_KYTSD
          Length = 144

 Score = 74.2 bits (181), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLTTVI 195
                 +A  V EE  E   A    D   L  E  DL++    H  +  +     +  V+
Sbjct: 32  EQTHASLAPFVLEEAEEVHEAIGEDDPAHLAEELGDLLWQVVVHAQLAAEAGEFTIDDVV 91

Query: 196 ENLR----KRH 202
             L     +RH
Sbjct: 92  AELEAKLLRRH 102


>UniRef50_Q2S3J2 MazG family protein n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3J2_SALRD
          Length = 281

 Score = 74.2 bits (181), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D  EL  E  D    +++H ++  +     L  VI
Sbjct: 46  EQTHESVKHLLIEEAYEVVAAIDHGDWDELAEELGDVLLHVLFHAVIAEEGGRFTLADVI 105

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 106 EAETDKLVRRH 116


>UniRef50_B2UPD1 MazG family protein n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UPD1_AKKM8
          Length = 269

 Score = 73.8 bits (180), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E       +D  +L  E  D++    +H  +  +    D   V 
Sbjct: 37  EQTHHSLISNMIEEAYEVVDTIQRNDWTQLREELGDVLLQVVFHAEIAQEAGRFDFNDVA 96

Query: 196 EN----LRKRH 202
                 L +RH
Sbjct: 97  AEVSEKLVRRH 107



 Score = 40.3 bits (93), Expect = 0.036,   Method: Composition-based stats.
 Identities = 16/66 (24%), Positives = 28/66 (42%), Gaps = 7/66 (10%)

Query: 142 GTKRIAQKVGEEGVET--ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI---- 195
             +    KV EE  E    L+A   D   +  E  DL++ ++ L + +G+D  T +    
Sbjct: 171 DAQGALDKVKEETAECGEILSAPEEDP-RVAEELGDLLFSVVNLCRKKGIDPETAMAGAN 229

Query: 196 ENLRKR 201
               +R
Sbjct: 230 RKFERR 235


>UniRef50_A9KR53 MazG family protein n=1 Tax=Clostridium phytofermentans ISDg
           RepID=A9KR53_CLOPH
          Length = 237

 Score = 73.8 bits (180), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 12/75 (16%), Positives = 22/75 (29%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLMY----HLLVLLQDQGLDL 191
                 +   + EE  E            D   L  E  D++     H  +  +     +
Sbjct: 28  EQTHDSLKNCMIEEAYEVVDGINQFTKNGDYDNLREELGDVLLQVIMHSQIAKEAGRFTV 87

Query: 192 TTVIEN----LRKRH 202
             VI+     + +RH
Sbjct: 88  EDVIDEIAKKMVRRH 102


>UniRef50_C6UMW7 Putative phosphoribosyl-ATP diphosphatase n=1 Tax=Candidatus
           Hodgkinia cicadicola Dsem RepID=C6UMW7_HODCD
          Length = 253

 Score = 73.8 bits (180), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 29/69 (42%), Positives = 44/69 (63%)

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
            S+T K+ A G  +I +KVGEE VE  LA    D   + +EA+D++YH+L+LL   GL L
Sbjct: 67  KSWTLKMLAEGLIQILKKVGEEAVEYVLAVVCADDHSVCSEAADVIYHVLLLLVAMGLSL 126

Query: 192 TTVIENLRK 200
            T+ + +R+
Sbjct: 127 NTLFDVIRR 135


>UniRef50_C6QD16 MazG family protein n=6 Tax=Proteobacteria RepID=C6QD16_9RHIZ
          Length = 335

 Score = 73.8 bits (180), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + IA    EE  E A A    D  +L +E  DL+    YH  +  +        V
Sbjct: 32  LEQNFETIAPYAIEEAYEVADAIARRDLPDLKDELGDLLLQVVYHARLAEEQGAFAFGDV 91

Query: 195 I----ENLRKRH 202
           +      + +RH
Sbjct: 92  VEAITRKMIRRH 103


>UniRef50_C4L178 Phosphoribosyl-ATP diphosphatase n=2 Tax=Exiguobacterium
           RepID=C4L178_EXISA
          Length = 102

 Score = 73.8 bits (180), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 39/89 (43%), Positives = 54/89 (60%), Gaps = 2/89 (2%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEA 173
            +++LEQL+  RK    E SYT  L+  G ++IA+K GEE  E  +AA      +L  E+
Sbjct: 1   MIHELEQLIQSRKDEPKEGSYTTYLFEQGVEKIAKKFGEESFEVVIAAMTD--EDLVEES 58

Query: 174 SDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           +DL+YHLLVLL  +G+ L  V   L KRH
Sbjct: 59  ADLLYHLLVLLAAKGVRLEDVEALLAKRH 87


>UniRef50_Q3AVT5 MazG n=4 Tax=Cyanobacteria RepID=Q3AVT5_SYNS9
          Length = 270

 Score = 73.8 bits (180), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +   V EE  E A A    D   L  E  DL+     H  +  +     L+ V
Sbjct: 30  LEQTHASLVPYVLEEAHEVADAIRHGDDAHLKEELGDLLLQVVLHAQIAKEGNRFALSDV 89

Query: 195 I----ENLRKRH 202
                  L +RH
Sbjct: 90  ADGINAKLIRRH 101



 Score = 45.3 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 13/61 (21%), Positives = 23/61 (37%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
                +  KV EE  E   A    D+     E  DL++ L+ + +  G+     +    +
Sbjct: 170 DDMAGVWAKVHEELDELKEAVISGDQSHAQEELGDLLFTLVNVARWCGIAPEEGLAGTNR 229

Query: 201 R 201
           R
Sbjct: 230 R 230


>UniRef50_B8HTG9 MazG family protein n=2 Tax=Chroococcales RepID=B8HTG9_CYAP4
          Length = 388

 Score = 73.8 bits (180), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 14/72 (19%), Positives = 22/72 (30%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
            A   + +   V EE  E   A    +   +  E  DL+        +  +     L  V
Sbjct: 128 LAQTPESLTPYVIEEAYEVVHAIREGEPAAIAEELGDLLLQVVLQAQIASEQAHFSLRDV 187

Query: 195 I----ENLRKRH 202
                  L +RH
Sbjct: 188 AQSISAKLIRRH 199



 Score = 41.8 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 18/76 (23%), Positives = 30/76 (39%), Gaps = 4/76 (5%)

Query: 130 PETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL 189
            E + TA L  +    +  K  EE  E   A   +D  +   E  DL++ L+ L +   L
Sbjct: 257 AEKAGTAGLDWTDISGVWDKFYEEFHEFQEALLQNDPVQQQAELGDLIFTLINLARWCQL 316

Query: 190 D----LTTVIENLRKR 201
           +    L    +   +R
Sbjct: 317 NPITALEETYQRFIRR 332


>UniRef50_C1SG07 MazG family protein n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SG07_9BACT
          Length = 257

 Score = 73.8 bits (180), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
                 I     EE  E   A    D   +  E  D    +++H ++  ++    +  V+
Sbjct: 26  EQNLLSIKNHFMEEAFELVDALDNEDIDNIREELGDVFFHVIFHAVMAEEEGKFSMEDVL 85

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 86  NEINEKLIRRH 96



 Score = 43.4 bits (101), Expect = 0.005,   Method: Composition-based stats.
 Identities = 12/63 (19%), Positives = 23/63 (36%), Gaps = 1/63 (1%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                  K  EE  E   A     + E+ +E  D+ + L+ L +   ++    +     R
Sbjct: 160 DMHGCMDKFNEEINEFKEAVATGSKDEIEHEMGDVFFSLINLSRFLKINPDEALRRANSR 219

Query: 202 -HQ 203
            H+
Sbjct: 220 FHK 222


>UniRef50_A4J0R1 MazG family protein n=4 Tax=Clostridia RepID=A4J0R1_DESRM
          Length = 505

 Score = 73.8 bits (180), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               K +   + EE  E   A      +++  E  DL+    +H  +  +++  ++  V+
Sbjct: 268 EQTHKSLKPYLIEETYEVLEALEQGQMYKICEELGDLLLQIVFHAQIASENKQFNMNDVV 327

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 328 QSITEKMIRRH 338


>UniRef50_B9XJR1 MazG family protein n=1 Tax=bacterium Ellin514 RepID=B9XJR1_9BACT
          Length = 223

 Score = 73.8 bits (180), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               K +     EE  E   A    D  E+  E  DL+    +H  +  +    +   V 
Sbjct: 28  EQDHKSLRWHAVEEVYELMDAIEAGDDHEMAEELGDLLLQVVFHCQMAQERGAFNFEKVA 87

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 88  RHLVDKLIRRH 98


>UniRef50_A8L147 MazG family protein n=4 Tax=Frankia RepID=A8L147_FRASN
          Length = 436

 Score = 73.4 bits (179), Expect = 5e-12,   Method: Composition-based stats.
 Identities = 17/73 (23%), Positives = 26/73 (35%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGL--DLTT 193
                 +A  + EE  E   A    D  EL  E  D    +++H  +  +  G   D+  
Sbjct: 165 EQNHVSLAPYLLEEAYEAYQAIEDGDLAELREELGDVLMQVLFHARIAAESGGAGWDVDD 224

Query: 194 VI----ENLRKRH 202
           V       L +RH
Sbjct: 225 VAAGLTAKLIRRH 237


>UniRef50_Q28PV1 MazG family protein n=8 Tax=Bacteria RepID=Q28PV1_JANSC
          Length = 265

 Score = 73.0 bits (178), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 18/71 (25%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA    EE  E A A    D  EL  E  DL+    +H  +       D   V 
Sbjct: 31  EQTFASIAPYTIEEAYEVADAIERGDMAELQGELGDLLFQSVFHAQMAEDGGHFDFDDVA 90

Query: 196 E----NLRKRH 202
                 +  RH
Sbjct: 91  RAIGDKMIARH 101


>UniRef50_B1C9L0 Putative uncharacterized protein n=1 Tax=Anaerofustis
           stercorihominis DSM 17244 RepID=B1C9L0_9FIRM
          Length = 449

 Score = 73.0 bits (178), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A   ++  +L  E  DL+     H  + +++   D   VI
Sbjct: 218 KQTHDSLKKHLLEETYELIDAIDRNNTEDLKEELGDLLLQIALHCQIEIENDSFDERDVI 277

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 278 DSISSKIIRRH 288


>UniRef50_Q04VW6 Pyrophosphatase n=6 Tax=Leptospira RepID=Q04VW6_LEPBJ
          Length = 296

 Score = 73.0 bits (178), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A   +D   L  E  DL+    +H  +  +    DL  V 
Sbjct: 56  EQDHQTLIPYLIEESQEVIEAILKNDDELLKEELGDLLFQVVFHARLAEERHSFDLGDVA 115

Query: 196 ----ENLRKRH 202
               + L  RH
Sbjct: 116 KSVSDKLIFRH 126


>UniRef50_Q0A8N1 MazG family protein n=4 Tax=Proteobacteria RepID=Q0A8N1_ALHEH
          Length = 292

 Score = 72.6 bits (177), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 18/72 (25%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
            A     IA    EE  E A A    D  +L +E  DL+    +H  +  ++       V
Sbjct: 51  LAQDFASIAPYTLEEAYEVAEAIRRGDMADLQDELGDLLLQVVFHARMAEEEGFFTFEDV 110

Query: 195 IE----NLRKRH 202
                  L +RH
Sbjct: 111 ARSISDKLVRRH 122



 Score = 43.0 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 13/68 (19%), Positives = 22/68 (32%), Gaps = 5/68 (7%)

Query: 141 SGTKRIAQKVGEEGVETALAATVH-DRFELTNEASDLMYHLLVLLQDQGLDLTTVI---- 195
                   KV EE  E A              E  DL++  + L +   +D  T +    
Sbjct: 189 DDPAGPLAKVREEADELAEEMAQGAGPERFEEELGDLLFATVNLARHLKVDPETAVQKAG 248

Query: 196 ENLRKRHQ 203
           +   +R +
Sbjct: 249 DKFERRFR 256


>UniRef50_C0AEE9 MazG family protein (Fragment) n=1 Tax=Opitutaceae bacterium TAV2
           RepID=C0AEE9_9BACT
          Length = 234

 Score = 72.6 bits (177), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 12/72 (16%), Positives = 24/72 (33%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  + + + +E  E       +D   +  E  D++    +H  +  +    DL  V
Sbjct: 57  IEQTHATLVRCLIDEVSELIDTIDRNDLPHMREELGDVLIQVIFHAQIASETGAFDLDDV 116

Query: 195 IEN----LRKRH 202
                  L +RH
Sbjct: 117 AREVNDKLIRRH 128


>UniRef50_D0MG87 MazG family protein n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MG87_RHOM4
          Length = 283

 Score = 72.6 bits (177), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 19/71 (26%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A   +D  EL  E  DL+    +H ++  Q     L  VI
Sbjct: 42  EQTHESVKHLLIEEAYEVVSAIEENDWEELKRELGDLLLHVVFHSVMAEQAGRFTLKDVI 101

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 102 ETETEKLIRRH 112


>UniRef50_B0K4Q4 MazG family protein n=10 Tax=Clostridia RepID=B0K4Q4_THEPX
          Length = 495

 Score = 72.6 bits (177), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 10/71 (14%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + + EE  E   A       ++  E  D++    +H  +  +    +   V+
Sbjct: 256 EQTHQSLEKYLVEESYELVDAIEKESEDKMVEELGDVLLQVVFHSQIAKERGTFNFGDVV 315

Query: 196 E----NLRKRH 202
           +     +  RH
Sbjct: 316 DGICKKMIWRH 326



 Score = 41.4 bits (96), Expect = 0.019,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 26/61 (42%), Gaps = 4/61 (6%)

Query: 147 AQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTV----IENLRKRH 202
             KV EE  E        D+ ++  E  DL++ ++ + +   ++  +     +E   KR 
Sbjct: 396 LSKVYEELEELKEVYKGKDKEKIIEEVGDLIFAVVNVARFLDVEPESATHNTVEKFIKRF 455

Query: 203 Q 203
           +
Sbjct: 456 E 456


>UniRef50_B9RGV5 Putative uncharacterized protein n=1 Tax=Ricinus communis
           RepID=B9RGV5_RICCO
          Length = 193

 Score = 72.6 bits (177), Expect = 8e-12,   Method: Composition-based stats.
 Identities = 23/103 (22%), Positives = 42/103 (40%), Gaps = 4/103 (3%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETAL 159
           G              + Q +  LA  +   P  S+T +L       +  K+ EE  E   
Sbjct: 78  GKRLALTTLYSLESTISQRKAELAAPQEGKP--SWTRRLL-DDPNLLCSKIREEADELCR 134

Query: 160 AATVHDRF-ELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               ++      +E  D++YH +VLL  + + +  V++ LR+R
Sbjct: 135 TLEENEHSIHTASEMGDVLYHAMVLLAHKDVKIEDVLDVLRQR 177


>UniRef50_D1X3V9 MazG nucleotide pyrophosphohydrolase n=5 Tax=Streptomyces
           RepID=D1X3V9_9ACTO
          Length = 335

 Score = 72.3 bits (176), Expect = 9e-12,   Method: Composition-based stats.
 Identities = 19/79 (24%), Positives = 31/79 (39%), Gaps = 13/79 (16%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG- 188
           +T++      + +A+   EE  E   A    DR EL  E  D++    +H  +  +D   
Sbjct: 147 WTSR---KTHRGLAKYAIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEDPDE 203

Query: 189 -LDLTTVI----ENLRKRH 202
              +  V     E L  RH
Sbjct: 204 PFAVDDVAGGLVEKLIHRH 222


>UniRef50_C8WFT9 MazG family protein n=3 Tax=Zymomonas mobilis RepID=C8WFT9_ZYMMN
          Length = 273

 Score = 72.3 bits (176), Expect = 9e-12,   Method: Composition-based stats.
 Identities = 19/71 (26%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A     IA    EE  E   A    D  EL NE  DL+    +H  +  +        V+
Sbjct: 38  AQNFLSIAPYAIEEAYEVVDAIEQQDMHELKNELGDLLLQVVFHSQMAAEKDLFTFDDVV 97

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 98  TAICEKMIRRH 108



 Score = 41.8 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 23/57 (40%), Gaps = 3/57 (5%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
           S T     K+ EE  E   A    DR  L  E  D+++ +    +  G+D    ++ 
Sbjct: 175 SDTAGPRAKIDEELAEVDNAT---DRENLIEEIGDVLFTVTTFARHHGIDAEQALKK 228


>UniRef50_C9N950 MazG nucleotide pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=C9N950_9ACTO
          Length = 328

 Score = 71.9 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 27/73 (36%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTT 193
               + +A+   EE  E   A    DR EL  E  D++    +H  +  +DQ     +  
Sbjct: 140 QKTHQGLAKYAIEEAYELVEAIEDGDREELREELGDVLLQVVFHARIAQEDQEEPFGIDD 199

Query: 194 VIE----NLRKRH 202
           V       L  RH
Sbjct: 200 VAATIVEKLIHRH 212


>UniRef50_C0QWZ2 Nucleoside triphosphate pyrophosphohydrolase n=2 Tax=Brachyspira
           RepID=C0QWZ2_BRAHW
          Length = 264

 Score = 71.9 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 13/70 (18%), Positives = 24/70 (34%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVI- 195
                +     EE  E   A    D   +  E  D++ H++    +   +   ++  V  
Sbjct: 26  QTFDSLIPCFLEEAYEVVEAINNRDYENIKEELGDVLLHVVFFSELAKDENKFNIDDVCK 85

Query: 196 ---ENLRKRH 202
              E L +RH
Sbjct: 86  NISEKLIRRH 95



 Score = 39.1 bits (90), Expect = 0.092,   Method: Composition-based stats.
 Identities = 17/59 (28%), Positives = 24/59 (40%), Gaps = 4/59 (6%)

Query: 147 AQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGL----DLTTVIENLRKR 201
             K+ EE +E   A    D+  L  E  DL+  +L   +   +     L  V E  RKR
Sbjct: 168 LSKIEEELLEVKDAYKEQDKEHLEEEIGDLIMTVLDFARMNKINPVNSLIKVNEKFRKR 226


>UniRef50_A8I3U9 Bacterial MazG protein n=124 Tax=Alphaproteobacteria
           RepID=A8I3U9_AZOC5
          Length = 283

 Score = 71.9 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 27/72 (37%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  +A    EE  E   A    D  +L +E  DL+    +H  +  +    ++  V
Sbjct: 28  LEQNFSTVAPYTIEEAYEVVDAIERGDLADLKDELGDLLLQVVFHARLAQEQGLFEMGDV 87

Query: 195 IE----NLRKRH 202
           +E     L +RH
Sbjct: 88  VEAITTKLIRRH 99



 Score = 50.7 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 12/65 (18%), Positives = 27/65 (41%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
           +  + +  K+ EE  E + A        + +E  DL++ ++ L +  G+D    +     
Sbjct: 175 NDARAVLAKIREETEEVSEALDAGGTEAIKDEVGDLLFAVVNLARHAGVDPEAALRGTNE 234

Query: 197 NLRKR 201
              +R
Sbjct: 235 KFTRR 239


>UniRef50_C9LLX3 MazG protein n=1 Tax=Dialister invisus DSM 15470 RepID=C9LLX3_9FIRM
          Length = 362

 Score = 71.9 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           +     +     +E  E   A   +D   L  E  D++    +H  +  ++    +  V+
Sbjct: 136 SQNHMTLRTYFLQEVYEVIDAIEENDILNLKEELGDVLLQVVFHARIAEENGEFSMQDVV 195

Query: 196 E----NLRKRH 202
           +     + KRH
Sbjct: 196 DGIANKMVKRH 206


>UniRef50_B4RXM6 MazG protein n=3 Tax=Proteobacteria RepID=B4RXM6_ALTMD
          Length = 321

 Score = 71.9 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 14/82 (17%), Positives = 27/82 (32%), Gaps = 8/82 (9%)

Query: 129 DPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLL 184
               S          + + +   EE  E A A    D  ++ +E  DL+    ++  +  
Sbjct: 23  RDPESGCPWDVKQTMESLTRYTIEEAYEVADAIASGDMHDIKDELGDLLFQVVFYAQIAS 82

Query: 185 QDQGLDLTTVI----ENLRKRH 202
           +        V     + L +RH
Sbjct: 83  ESSAFSFDDVAQSISDKLVRRH 104


>UniRef50_B5JET8 MazG family protein n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JET8_9BACT
          Length = 267

 Score = 71.9 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 13/72 (18%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +AQ + +E  E        D   +  E  D++    +H  + ++    D   V
Sbjct: 67  IEQDHQSLAQCLVDECSELLETIDKLDMDHMREELGDVLLQVVFHAQLAMEAGHFDFDAV 126

Query: 195 IEN----LRKRH 202
                  L +RH
Sbjct: 127 AAEINEKLVRRH 138


>UniRef50_B1YGQ0 MazG family protein n=5 Tax=Bacillales RepID=B1YGQ0_EXIS2
          Length = 476

 Score = 71.5 bits (174), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + + EE  E   A  + D   +  E  D++     H  + L +   D+  VI
Sbjct: 251 EQTHESLKKHLIEESYELLEAIDLQDDNLMIEELGDVLLQVMLHAQIGLDEGYFDVRDVI 310

Query: 196 ----ENLRKRH 202
               + + +RH
Sbjct: 311 GSVSDKMIRRH 321


>UniRef50_B1ZW78 MazG family protein n=1 Tax=Opitutus terrae PB90-1
           RepID=B1ZW78_OPITP
          Length = 225

 Score = 71.5 bits (174), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 10/71 (14%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + +E  E        D   +  E  D++    +H  +  +    +   V 
Sbjct: 25  EQTHATLVRCLIDEVSELIDTIDRGDMPHMREELGDVLIQIVFHARMAEEAGHFNFEDVA 84

Query: 196 EN----LRKRH 202
                 L +RH
Sbjct: 85  REINEKLVRRH 95


>UniRef50_A6FDM3 MazG family protein n=1 Tax=Moritella sp. PE36 RepID=A6FDM3_9GAMM
          Length = 264

 Score = 71.5 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTV 194
                  IA+   EE  E   +   +D   L  E  DL+YH+     +  +        V
Sbjct: 28  LQQNFASIAKFTLEEAYEVVDSIESNDIKGLEGEIGDLLYHVLYYTQLGQEQALFSFDDV 87

Query: 195 I----ENLRKRH 202
           I      L +RH
Sbjct: 88  IQQLAAKLIRRH 99


>UniRef50_B0CCR5 MazG family protein n=8 Tax=Cyanobacteria RepID=B0CCR5_ACAM1
          Length = 411

 Score = 71.5 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 12/72 (16%), Positives = 22/72 (30%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +   + EE  ET  A        +  E  DL+        +  +     L  +
Sbjct: 133 LEQTPQSLTPYIIEEAYETIDAIQSGSTEAIAEELGDLLLQVVLQAQIACEQDQFSLEEI 192

Query: 195 IE----NLRKRH 202
            +     L +RH
Sbjct: 193 AQGITKKLIRRH 204



 Score = 39.5 bits (91), Expect = 0.069,   Method: Composition-based stats.
 Identities = 14/65 (21%), Positives = 23/65 (35%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
                +  K  EE  E   +    D     +E  DL + L+ + +   LD T+ +     
Sbjct: 273 QDLNDVWTKFYEELAEFQESLLQSDTEHQLSELGDLFFTLVNVARWCQLDPTSALRSTNK 332

Query: 197 NLRKR 201
            L  R
Sbjct: 333 KLIDR 337


>UniRef50_C1TQS2 MazG family protein n=3 Tax=Synergistaceae RepID=C1TQS2_9BACT
          Length = 275

 Score = 71.5 bits (174), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D   +  E+ DL+    +  ++  +     L  ++
Sbjct: 30  KQTYGSLRPHIIEEAYELVDAVDNGDIAGICEESGDLLLQVVFIGVIAEESGDFSLADIV 89

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 90  RSISDKLIRRH 100



 Score = 41.1 bits (95), Expect = 0.022,   Method: Composition-based stats.
 Identities = 12/43 (27%), Positives = 21/43 (48%)

Query: 149 KVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDL 191
           K+ EE  E   A    DR  +  E  D+++ ++ L +  G+D 
Sbjct: 175 KIDEEIDEVKTAMESEDRLSMEEEIGDVLFSIVNLARRLGVDP 217


>UniRef50_B0TBB1 Mazg family protein n=4 Tax=Bacteria RepID=B0TBB1_HELMI
          Length = 546

 Score = 71.1 bits (173), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A  + D  +L  E  D++    +H L+   +    ++ ++
Sbjct: 295 EQSHQSLKPYLLEEAYEVLEAIDLGDDGKLKEELGDVLLQVVFHGLIAEGEGRFRISEIV 354

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 355 ETITEKMVRRH 365


>UniRef50_D1PLC7 MazG protein n=3 Tax=Ruminococcaceae RepID=D1PLC7_9FIRM
          Length = 225

 Score = 71.1 bits (173), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 14/70 (20%), Positives = 22/70 (31%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL----T 192
              + I     EE  E   A  + D   L  E  D++    +H  +  +           
Sbjct: 36  QTHQSIRMNFLEEAYEAVDAIDLEDSHLLCEELGDVLMQVAFHAQIEQEAGHFTWQQVCD 95

Query: 193 TVIENLRKRH 202
            V   L +RH
Sbjct: 96  GVCRKLIQRH 105


>UniRef50_Q0B0R5 MazG protein n=1 Tax=Syntrophomonas wolfei subsp. wolfei str.
           Goettingen RepID=Q0B0R5_SYNWW
          Length = 255

 Score = 71.1 bits (173), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL---- 191
               + + + + EE  E   A  + D  +L  E  DL+    +H  +  ++   D     
Sbjct: 29  EQTHESLQRYLIEESYEVIEAIKMQDMHKLREELGDLLLQVVFHAALAEREGHFDFAGVA 88

Query: 192 TTVIENLRKRH 202
            TV + +  RH
Sbjct: 89  DTVKKKMIARH 99



 Score = 41.1 bits (95), Expect = 0.021,   Method: Composition-based stats.
 Identities = 11/55 (20%), Positives = 23/55 (41%), Gaps = 3/55 (5%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
           G +   +K  EE  E   A       E+  E  D+ + L+ + + + +D    ++
Sbjct: 160 GVEGALEKFKEEVEELVAATK---PEEIKEEMGDVFFALVNVARLKNIDPEEALQ 211


>UniRef50_Q7URL1 Phosphoribosyl-ATP pyrophosphatase n=2 Tax=Planctomycetaceae
           RepID=HIS2_RHOBA
          Length = 120

 Score = 71.1 bits (173), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 34/92 (36%), Positives = 46/92 (50%), Gaps = 3/92 (3%)

Query: 114 FLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHD---RFELT 170
            L +L   L  R +  PE SYT KL   G + I +K+ EE  E   AA   D   R    
Sbjct: 7   PLDRLMTTLRTRAAERPEGSYTTKLMNGGAEAIGRKIREEAEELIEAADEPDEAGRQHAI 66

Query: 171 NEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
            EA DL+YH +VL+  +G++L  V   L +R 
Sbjct: 67  YEAGDLIYHAMVLMAWRGIELDEVAAELARRE 98


>UniRef50_B9CMC9 Tetrapyrrole methylase family protein, MazG family protein n=1
           Tax=Atopobium rimae ATCC 49626 RepID=B9CMC9_9ACTN
          Length = 298

 Score = 71.1 bits (173), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 19/109 (17%), Positives = 31/109 (28%), Gaps = 15/109 (13%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
                    ++  L +    L +      +        A     I + + EE  E   A 
Sbjct: 28  RPGAPMGHPEFDRLVRTIWRLRQSDGCPWDK-------AQTHDSITKNMIEEAYEAVEAI 80

Query: 162 TVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVIE----NLRKRH 202
                  L  E  D    ++ H  +   D G D+  V       L +RH
Sbjct: 81  KEGSSEHLQEELGDVLEQVLLHSQIESDDGGFDIDGVCRALNEKLVRRH 129


>UniRef50_D0L751 MazG nucleotide pyrophosphohydrolase n=1 Tax=Gordonia bronchialis
           DSM 43247 RepID=D0L751_GORB4
          Length = 322

 Score = 70.7 bits (172), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 22/127 (17%), Positives = 39/127 (30%), Gaps = 15/127 (11%)

Query: 84  DTLLVLANPIGP---TCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA 140
           DT+L+  +   P          +           L +   L+   +   P  S       
Sbjct: 59  DTVLISTDAEHPIVRARIARGDTVIAARRVPGSALLEAVALMDTLRGNGPWES------R 112

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQG--LDLTTV 194
                + + + EE  E   A    D  EL  E  DL    ++H  +   D     D+  V
Sbjct: 113 QTHASLRRYLLEEVYELLDAIDHDDPAELCEELGDLLLQVLFHARIAADDPDAPFDIDDV 172

Query: 195 IENLRKR 201
             +  ++
Sbjct: 173 ARSFTRK 179


>UniRef50_C0GPL2 Type III restriction protein res subunit n=1
           Tax=Desulfonatronospira thiodismutans ASO3-1
           RepID=C0GPL2_9DELT
          Length = 978

 Score = 70.7 bits (172), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 19/106 (17%), Positives = 42/106 (39%), Gaps = 7/106 (6%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVET 157
           H  +   +     +     ++  ++ E+      +S + + +        QK+ EE  E 
Sbjct: 4   HSNSHPIYYYKLVR----DKIPSIIREKGHHPAVSSLSGQQWTQAAS---QKLLEEAYEL 56

Query: 158 ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             A    D+  +  E+SD++   L +L+ Q      ++  L KR +
Sbjct: 57  FTAIANGDKESVLKESSDVLEITLTILKQQNYSFDDLLAELEKRRE 102


>UniRef50_B2IB76 MazG family protein n=8 Tax=Alphaproteobacteria RepID=B2IB76_BEII9
          Length = 302

 Score = 70.7 bits (172), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 19/71 (26%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA    EE  E A A T  DR +L +E  DL+    +H  +  ++   D   V+
Sbjct: 57  QQTYATIAPYTIEEAYEVADAITREDRADLRDELGDLLFQVVFHSRLAEEEGAFDFGGVV 116

Query: 196 ----ENLRKRH 202
                 + +RH
Sbjct: 117 EAITAKMIRRH 127



 Score = 49.5 bits (117), Expect = 6e-05,   Method: Composition-based stats.
 Identities = 14/64 (21%), Positives = 23/64 (35%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----N 197
             + +  KV EE  E   A       E+  E  DL++ +  L +   +D    I      
Sbjct: 201 DARLVLAKVREETREIEEAIASGQAEEIHAEIGDLLFTIANLARHLNVDPEAAIRSTNAK 260

Query: 198 LRKR 201
             +R
Sbjct: 261 FERR 264


>UniRef50_A8ZVD0 MazG family protein n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZVD0_DESOH
          Length = 269

 Score = 70.7 bits (172), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ----DQGLDLTTVI 195
               + +   + EE  E   A    D  ++  E  DL++H+L L          DL  V 
Sbjct: 35  EQTPRSMTVYLVEEVHELVDAIMEADPAKICEELGDLLFHILFLESIFRGRGDFDLQDVA 94

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 95  RISAEKMIRRH 105



 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 15/64 (23%), Positives = 27/64 (42%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT----TVIEN 197
            T  +  K+ EE  E   A   +D+  +T E  DL++ L+ L +   +         ++ 
Sbjct: 171 DTAGVMDKIKEEFAELEAAMAENDKAHVTEEVGDLLFSLVNLARFLRVHPETALADTVKK 230

Query: 198 LRKR 201
             KR
Sbjct: 231 FEKR 234


>UniRef50_C0QR38 MazG family protein n=4 Tax=Hydrogenothermaceae RepID=C0QR38_PERMH
          Length = 261

 Score = 70.7 bits (172), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I   + EE  E   A    D   +  E  DL+    +H  +   +   D+  V+
Sbjct: 32  EQTNQSIKNNLIEEAYELFEAIESDDDKAMVEELGDLLLQVVFHSQIKKDEGSFDINDVL 91

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 92  ENLKEKLIRRH 102


>UniRef50_A4EC03 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens
           ATCC 25986 RepID=A4EC03_9ACTN
          Length = 286

 Score = 70.3 bits (171), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 21/71 (29%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I + + EE  E        D   L  E  D++     H  +        L  V 
Sbjct: 47  EQTHRSIGKNMIEEAYEALDCIEADDATHLREELGDVLMQVVLHAQIAADAGEFSLADVA 106

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 107 RDIDAKLIRRH 117


>UniRef50_Q1IPL4 MazG family protein n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IPL4_ACIBL
          Length = 405

 Score = 70.3 bits (171), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
                 I     EE  E   A    D  EL  E  DL    +++  +  ++    +  V+
Sbjct: 136 EQTFDTIKPFTLEETYEVIEAIDNRDWDELPGELGDLLLQILFYAQMAAEEGKFTIDEVV 195

Query: 196 E----NLRKRH 202
           E     L  RH
Sbjct: 196 ETLSNKLVNRH 206


>UniRef50_A5UM80 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Methanobacteriaceae
           RepID=HIS2_METS3
          Length = 96

 Score = 70.3 bits (171), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 6/97 (6%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYA----SGTKRIAQKVGEEGVETALAATVHD 165
                + +    + E +  +P  SYT+K+          +I +KV EE  E  LAA    
Sbjct: 1   MASEEIIREVYKVLEERRDNPIDSYTSKIMQDSDKKAEDKILEKVAEECGEVLLAAKND- 59

Query: 166 RFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
              L  E+ DL++H L++L  +G+++  + E   +R 
Sbjct: 60  -ENLVYESVDLIFHTLLILVYKGIEIDEIFEEFARRR 95


>UniRef50_B6GA15 Putative uncharacterized protein n=2 Tax=Collinsella
           RepID=B6GA15_9ACTN
          Length = 290

 Score = 69.9 bits (170), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 21/71 (29%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA+ + EE  E        D   L  E  D++     H  +        +  + 
Sbjct: 50  KQTHASIAKNMIEEAYEAVDCIEADDAAHLREELGDVLMQVVLHAQIAADAGAFTMADIA 109

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 110 RDINEKLVRRH 120


>UniRef50_A4YI36 Phosphoribosyl-ATP pyrophosphatase n=3 Tax=Sulfolobaceae
           RepID=HIS2_METS5
          Length = 93

 Score = 69.9 bits (170), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 38/91 (41%), Positives = 55/91 (60%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L  ++A+R    PE SYTA L   G   +A+KVGEE VE  +A+    R  + +E
Sbjct: 3   DVLEELSGIIAQRLREMPEGSYTASLAKKGKGYVARKVGEEAVEVVVASLSEGRERVVSE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
            +DL+YHLLVLL  +G+ L  V + LR+R +
Sbjct: 63  TADLIYHLLVLLAMEGISLDEVRDELRRRMK 93


>UniRef50_C7MMP1 MazG family protein n=2 Tax=Coriobacteriaceae RepID=C7MMP1_CRYCD
          Length = 307

 Score = 69.9 bits (170), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + IA+ + EE  E   A    DR  L  E  D++        +        +  V 
Sbjct: 46  KQTHESIAKNMLEEAFEAVAAIEEADRDHLIEELGDVLLQVVLQAQIAADAGEFTIDDVA 105

Query: 196 ----ENLRKRH 202
               E + +RH
Sbjct: 106 QAVNEKIIRRH 116


>UniRef50_B1M6G5 MazG family protein n=3 Tax=Proteobacteria RepID=B1M6G5_METRJ
          Length = 303

 Score = 69.9 bits (170), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A     I     EE  E A A    D  +L +E  DL+    +H  +  +        V 
Sbjct: 48  AQSFATIVPYTIEEAYEVADAVARGDLRDLRDELGDLLLQVVFHARMAEEQGAFAFDDVA 107

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 108 RAIGDKLVRRH 118



 Score = 57.2 bits (137), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 16/65 (24%), Positives = 27/65 (41%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE---- 196
               ++  KV EE  E A A    D   ++ E  DL++ +  L +  G+D  T +     
Sbjct: 200 DDAAQVVAKVREETDEVAEALAAGDPEAVSEEIGDLLFSVANLARHAGIDPETALRDGTA 259

Query: 197 NLRKR 201
              +R
Sbjct: 260 KFERR 264


>UniRef50_C8W8X4 MazG family protein n=2 Tax=Coriobacteriaceae RepID=C8W8X4_ATOPD
          Length = 300

 Score = 69.6 bits (169), Expect = 6e-11,   Method: Composition-based stats.
 Identities = 17/123 (13%), Positives = 33/123 (26%), Gaps = 26/123 (21%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
                    T  ++  L +    L +      +            + I++ + EE  E  
Sbjct: 18  TKARPGAPQTHPEFDRLVRTIWRLRQEDGCPWDK-------EQTHQSISKNMIEEAYEAV 70

Query: 159 LAATVHDRFELTNEASDLM----YHLLVLL-----------QDQGLDLTTVIE----NLR 199
            A        L  E  D++     H  +             +  G ++  V       L 
Sbjct: 71  EAIAEGSPEHLEEELGDVLEQVVLHSQIEADGGVDSAGEGDRAAGFNIDDVCRALNQKLV 130

Query: 200 KRH 202
           +RH
Sbjct: 131 RRH 133


>UniRef50_Q3Z619 MazG family protein n=5 Tax=Dehalococcoides RepID=Q3Z619_DEHE1
          Length = 264

 Score = 69.6 bits (169), Expect = 6e-11,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   K +   + EE  E   A    D      E  DL+    +H  +  + +  ++  VI
Sbjct: 31  AQTHKSMRDSLLEETYEVLEALDAEDTGRFCGELGDLLLQIVFHAEIGAEAKEFNMGDVI 90

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 91  EAINTKLIRRH 101


>UniRef50_B5HJI9 Nucleoside triphosphate pyrophosphohydrolase n=2 Tax=Streptomyces
           RepID=B5HJI9_STRPR
          Length = 293

 Score = 69.6 bits (169), Expect = 6e-11,   Method: Composition-based stats.
 Identities = 19/77 (24%), Positives = 28/77 (36%), Gaps = 14/77 (18%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVL------LQDQGL 189
               K +A+   EE  E   A    DR EL  E  D++    +H  +        +D+  
Sbjct: 104 QQTHKGLAKYGIEEAYELVEAIEDGDRDELREELGDVLLQVVFHARIAEEGGPGEEDEPF 163

Query: 190 DLTTVI----ENLRKRH 202
            +  V     E L  RH
Sbjct: 164 SIDDVAGTIVEKLIHRH 180


>UniRef50_C0WDQ0 Putative uncharacterized protein n=1 Tax=Acidaminococcus sp. D21
           RepID=C0WDQ0_9FIRM
          Length = 264

 Score = 69.6 bits (169), Expect = 6e-11,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   K + +++ EE  E   A    D   +  E  D++    +H  +  +     +  VI
Sbjct: 33  AQDHKSMRRELVEEVYELLEAIDDGDVKGIREELGDVLFQVVFHARLAEEVGAFTMQDVI 92

Query: 196 ----ENLRKRH 202
                 L  RH
Sbjct: 93  TDVSRKLIHRH 103



 Score = 42.2 bits (98), Expect = 0.011,   Method: Composition-based stats.
 Identities = 14/48 (29%), Positives = 22/48 (45%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI 195
           +KV EE  E   A    ++  +  E  DL + L V  +  GL+  T +
Sbjct: 172 EKVKEEENELKEAILSKNKDHVEEELGDLFFALSVYARKLGLEPETAL 219


>UniRef50_C1XVA0 MazG family protein n=2 Tax=Deinococci RepID=C1XVA0_9DEIN
          Length = 188

 Score = 69.6 bits (169), Expect = 7e-11,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A T  D   L  E  D++    +H ++  +        V 
Sbjct: 15  EQTHLSLRPYMLEEAAEAVDAMTAGDMPHLAEELGDVLLQVAFHSVIAEEAGSFTYPQVE 74

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 75  RLIVDKLIRRH 85


>UniRef50_A7VWY5 Putative uncharacterized protein n=4 Tax=Clostridiales
           RepID=A7VWY5_9CLOT
          Length = 275

 Score = 69.6 bits (169), Expect = 7e-11,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I Q   EE  E   A    D   L  E  D++    +H L+  +    D + V 
Sbjct: 32  EQTHESIRQNFIEETYEAIEAIDTKDTELLKEELGDVLMQVVFHALMEEEAGKFDFSDVA 91

Query: 196 E----NLRKRH 202
           +     L  RH
Sbjct: 92  DGVCHKLIIRH 102


>UniRef50_D2PPA8 MazG family protein n=2 Tax=Actinomycetales RepID=D2PPA8_9ACTO
          Length = 346

 Score = 69.6 bits (169), Expect = 7e-11,   Method: Composition-based stats.
 Identities = 24/145 (16%), Positives = 39/145 (26%), Gaps = 39/145 (26%)

Query: 85  TLLVLANPIGPTCHKGTSS---------CFGDTAHQWLFLYQLEQLLAERKSADPETSYT 135
            LL L        H G                       L  ++ +   R++   +    
Sbjct: 86  ALLRLV-----ADHLGREPRPAYEVEILHGSYDVPGARLLDLVQVMDRLRRNCPWDQ--- 137

Query: 136 AKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQD----- 186
                     +A+ + EE  ET  A    DR  L  E  DL+    +H  +  +      
Sbjct: 138 ----EQTHASLAKYLLEETYETLEAIDSGDREHLREELGDLLLQVVFHARIAEEAPAEDE 193

Query: 187 -----QGLDLTTVIE----NLRKRH 202
                    +  V       L +RH
Sbjct: 194 DDESDGPWSIDDVAAGIVEKLIRRH 218


>UniRef50_C7R009 MazG family protein n=1 Tax=Jonesia denitrificans DSM 20603
           RepID=C7R009_JONDD
          Length = 241

 Score = 69.6 bits (169), Expect = 7e-11,   Method: Composition-based stats.
 Identities = 13/73 (17%), Positives = 23/73 (31%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQG--LDLTT 193
                 + + + EE  E   A    D   +  E  D    +++H  +  +       +  
Sbjct: 51  EQTHTSLVRYLLEETYELVDAIESGDHTHMREELGDVLLQVLFHARIAEEHPDTPFTIDD 110

Query: 194 V----IENLRKRH 202
           V       LR RH
Sbjct: 111 VAHDLAAKLRHRH 123


>UniRef50_D1N5T1 MazG family protein n=1 Tax=Victivallis vadensis ATCC BAA-548
           RepID=D1N5T1_9BACT
          Length = 277

 Score = 69.2 bits (168), Expect = 7e-11,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
               + +++ + EE  E   A    +  ++ +E  DL+    +  +V  +        V 
Sbjct: 32  EQTRETLSRSLAEEAAEVLDAIDRGNAPDICDELGDLLMNVIFQAVVAEERGEFTFQDVC 91

Query: 195 ---IENLRKRH 202
              I+ + +RH
Sbjct: 92  GGIIDKMIRRH 102


>UniRef50_Q1K0K7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Desulfuromonas
           acetoxidans DSM 684 RepID=Q1K0K7_DESAC
          Length = 235

 Score = 69.2 bits (168), Expect = 8e-11,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
                 I + + EE  E   A   +   ++ +E  DL+    +   +  +    +L  V 
Sbjct: 33  KQTPDTIKKHLLEEAYEVLDAIDHNISEDICSELGDLLMQIYFLADIYEEAGQFELFDVS 92

Query: 195 ---IENLRKRH 202
                 L +RH
Sbjct: 93  EAIQAKLIRRH 103


>UniRef50_B0MPG5 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM
           15702 RepID=B0MPG5_9FIRM
          Length = 288

 Score = 69.2 bits (168), Expect = 8e-11,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDL---- 191
               K +   V EE  E   A    D   L  E  DL+    +H  +  +    +     
Sbjct: 59  EQDHKSVRMNVLEEAYEVMEAIDADDAAMLKEELGDLLFQAVFHCEIEKERGRFEFNDIC 118

Query: 192 TTVIENLRKRH 202
             V + +  RH
Sbjct: 119 DDVTKKMIYRH 129


>UniRef50_B1XI42 MazG family protein n=22 Tax=Cyanobacteria RepID=B1XI42_SYNP2
          Length = 278

 Score = 69.2 bits (168), Expect = 9e-11,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +   V EE  E   A    D+  +  E  DL+        +  +     L  V
Sbjct: 35  LEQTPQTLIPYVIEEAYEVVHALRQDDQQAIAEELGDLLLQVVLQAQIAQEYGHFSLQEV 94

Query: 195 I----ENLRKRH 202
                E L +RH
Sbjct: 95  AEGISEKLIRRH 106



 Score = 40.3 bits (93), Expect = 0.041,   Method: Composition-based stats.
 Identities = 11/52 (21%), Positives = 19/52 (36%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
                +  K  EE  E   A    ++     E  DL++ ++ L +   LD  
Sbjct: 175 ENIGEVWAKFEEELQEFREALQTENKAHQQAELGDLLFTVVNLARWYDLDPN 226


>UniRef50_B8KRH4 MazG family protein n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KRH4_9GAMM
          Length = 275

 Score = 68.8 bits (167), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                K I     EE  E   A    D   +  E  DL+    ++  +  +    D  +V
Sbjct: 32  LKQNFKSITASTLEESYELVDAIEREDMPHVAEELGDLLFQVIFYSQLGKEAGDFDFDSV 91

Query: 195 ----IENLRKRH 202
               +E L +RH
Sbjct: 92  THTLVEKLIRRH 103


>UniRef50_A9FF91 Putative uncharacterized protein mazG n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9FF91_SORC5
          Length = 284

 Score = 68.4 bits (166), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + V EE  E   A    DR EL  E  DL+    +   +   +       VI
Sbjct: 42  EQSFATLRRYVLEEACEVIDAIDGGDRKELCAELGDLLLQVVFQAELARAEGAFGPDDVI 101

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 102 AAICEKLVRRH 112



 Score = 43.0 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 15/71 (21%)

Query: 147 AQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD---------------L 191
             KV EE  E   A    D   +  E  D+++ L  L +  G+D                
Sbjct: 183 RAKVDEELGELDRALDGGDSAAIEEELGDVLFALGNLARHAGVDAEGALRRTIDKFTRRF 242

Query: 192 TTVIENLRKRH 202
             V   + +RH
Sbjct: 243 DHVERRVIERH 253


>UniRef50_P44723 Protein mazG homolog n=57 Tax=Gammaproteobacteria RepID=MAZG_HAEIN
          Length = 263

 Score = 68.4 bits (166), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 14/72 (19%), Positives = 25/72 (34%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +   + EE  E   A    D   L  E  DL+    +   +  +D+      V
Sbjct: 26  LKQNYESMISCLTEETYEVIEAIEKKDIPNLREELGDLLLQVVFFSQLAREDKYFAFDDV 85

Query: 195 I----ENLRKRH 202
           +    E + +RH
Sbjct: 86  LQDVAEKIVRRH 97


>UniRef50_Q2JT55 MazG family protein n=4 Tax=Bacteria RepID=Q2JT55_SYNJA
          Length = 364

 Score = 68.4 bits (166), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTVI 195
           A   + +   + EE  ET  A    D   +  E  DL+  +     +  +    DL TV 
Sbjct: 116 AQTPESLTPYILEEAYETVAAIRAGDPAAIAEELGDLLLQVVLQSQIFAERNHFDLETVA 175

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 176 ARIADKLIRRH 186


>UniRef50_B8D010 MazG family protein n=3 Tax=Bacteria RepID=B8D010_HALOH
          Length = 265

 Score = 68.0 bits (165), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A    D   L  E  DL+    +   +  +    +L  VI
Sbjct: 31  KQDYYTLKPYIIEEAYEVVEALQKDDLELLKEELGDLLLQVVFESQIGKEKGDFNLIDVI 90

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 91  KIISEKLIRRH 101



 Score = 42.2 bits (98), Expect = 0.010,   Method: Composition-based stats.
 Identities = 9/52 (17%), Positives = 22/52 (42%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
                + +K+ EE  E       ++  E+  E  DL++ ++ L +   ++  
Sbjct: 167 DNISDVVRKIEEELAEVKEVIKTNEHKEIEEELGDLIFAVVNLCRFYRINPE 218


>UniRef50_C7QJ07 MazG family protein n=7 Tax=Actinomycetales RepID=C7QJ07_CATAD
          Length = 358

 Score = 68.0 bits (165), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 14/80 (17%), Positives = 25/80 (31%), Gaps = 17/80 (21%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHD-------RFELTNEASDLM----YHLLVLLQDQG 188
                 + + + EE  ET       D       R  L  E  D++    +H  +  + + 
Sbjct: 161 EQTHASLVKYLLEEAYETVETIEDGDPLTPGPGRDALREELGDVLLQVMFHSRIAEEHEA 220

Query: 189 --LDLTTVI----ENLRKRH 202
               +  V       L +RH
Sbjct: 221 DPFSVDDVADGIVAKLIRRH 240


>UniRef50_C8WJX9 MazG family protein n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WJX9_EGGLE
          Length = 323

 Score = 67.6 bits (164), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTVI 195
               + IA  + EE  E   A    D   L  E  D++  +     +       D+  V 
Sbjct: 54  TQTHQSIAHNMIEEAYEAVDAIEAADVAHLREELGDVLLQVVLQSQIASDAGEFDINDVC 113

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 114 ADVNEKMVRRH 124


>UniRef50_B1GYU5 Putative nucleotide pyrophosphohydrolase MazG n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GYU5_UNCTG
          Length = 132

 Score = 67.6 bits (164), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + + + +  E  E   A    D   L  E  D++    +H  +  + +  ++  VI
Sbjct: 29  KQTHESLVKHLFSEAEEVKKAVKNGDMDNLEEELGDILLQVVFHAQIAKESKSFNIAGVI 88

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 89  EKLNKKLVRRH 99


>UniRef50_C1F8P3 MazG family protein n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F8P3_ACIC5
          Length = 284

 Score = 67.6 bits (164), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
                 I +   EE  E   A    +  EL +E  DL    +++  +  +    D+  V+
Sbjct: 32  EQDFHSIRKYTLEEVYEVFDAIETGNWDELRSELGDLLLQVLFYAQMAAEPGYFDVADVV 91

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 92  ETLNLKLIRRH 102



 Score = 39.5 bits (91), Expect = 0.075,   Method: Composition-based stats.
 Identities = 14/64 (21%), Positives = 25/64 (39%), Gaps = 5/64 (7%)

Query: 143 TKRIAQKVGEEGVET-ALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT----TVIEN 197
            + +  KV EE  E  A  A    + ++  E  DL++ +  L +   +D           
Sbjct: 184 VQGLLAKVREETAEVEAELAQSEGQRKIEEEIGDLLFTVANLARHLKVDPELALRDANAK 243

Query: 198 LRKR 201
            R+R
Sbjct: 244 FRRR 247


>UniRef50_D0LI16 MazG family protein n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LI16_HALO1
          Length = 289

 Score = 67.2 bits (163), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 11/71 (15%), Positives = 21/71 (29%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 +   + EE  E   A       +   E  DL+    +   +   +    +  V+
Sbjct: 50  EQTLSTLIPYLIEESYEVIDAIETGTPADHCEELGDLLLQIVFQAALREAEGQFGIDDVV 109

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 110 RGIADKLVRRH 120



 Score = 46.1 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 15/56 (26%), Positives = 24/56 (42%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
             T   + KV EE  E   AA   D+  +  E  DL++ ++ L +  G D    + 
Sbjct: 189 EDTAGCSAKVREELGEVEHAAASGDQAAVEAEIGDLLFAVVSLARKHGCDPEHALR 244


>UniRef50_D1A7M2 MazG family protein n=8 Tax=Actinomycetales RepID=D1A7M2_THECD
          Length = 329

 Score = 67.2 bits (163), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 14/74 (18%), Positives = 22/74 (29%), Gaps = 11/74 (14%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG---LDLT 192
                 +   + EE  E A      D   L  E  D++    +H  V  +        + 
Sbjct: 136 KQTHATLVPYLLEEAYELADTVEDGDYAALREELGDVLMQVVFHARVAEERTDDTRFTID 195

Query: 193 TVIE----NLRKRH 202
            V       L +RH
Sbjct: 196 DVAAGIVDKLVRRH 209


>UniRef50_C7JCN1 Nucleotide pyrophosphohydrolase MazG n=8 Tax=Acetobacter
           pasteurianus RepID=C7JCN1_ACEP3
          Length = 325

 Score = 67.2 bits (163), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + IA    EE  E   A    D     +E  DL+    Y   +  ++   D  TV 
Sbjct: 72  EQTHETIAPYAIEEAYEVLDAIQKKDWNAFPDELGDLLLQVVYQAQLAQEEGRFDFATVA 131

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 132 RMITEKMIRRH 142


>UniRef50_A6G509 MazG family protein n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G509_9DELT
          Length = 304

 Score = 67.2 bits (163), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   + +     EE  E   A    D  E   E  DL+    +H  +  ++   DL  V+
Sbjct: 51  AQTLESLRPYAVEEAHEVLEAIDGGDPEEHRRELGDLLFQIVFHAALREREGAFDLDGVV 110

Query: 196 E----NLRKRH 202
           E     + +RH
Sbjct: 111 EAIRSKMIRRH 121



 Score = 42.6 bits (99), Expect = 0.008,   Method: Composition-based stats.
 Identities = 13/64 (20%), Positives = 24/64 (37%), Gaps = 4/64 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----N 197
                  K  EE  E   A    D+  +  E  DL++ L+ + Q  G++  + +      
Sbjct: 206 DLDGPRDKAREEWAELEEAIASGDQQAIAEEFGDLLFVLVRMGQKLGVEAESALRATNLK 265

Query: 198 LRKR 201
             +R
Sbjct: 266 FERR 269


>UniRef50_B0VJQ1 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VJQ1_9BACT
          Length = 255

 Score = 66.9 bits (162), Expect = 4e-10,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 24/72 (33%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH----LLVLLQDQGLDLTTV 194
                + +     EE  E   A    D   L  E  DLM H      +  +    ++  V
Sbjct: 25  LKQTRESLVPNFIEELYEVVEAIENKDYDALKEELGDLMLHIVMQAQISKEQGLWNIDDV 84

Query: 195 IEN----LRKRH 202
           +E     L +RH
Sbjct: 85  LEEISSKLIRRH 96



 Score = 45.7 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 30/61 (49%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
              K I +K+ EE  E A A   +++  +  E  D+++ L+ + +   +D  + ++   +
Sbjct: 158 QDIKPILEKLDEERDELAEALNSNEQDAIKEELGDMIFTLVNMARKLHIDAESALKECIR 217

Query: 201 R 201
           +
Sbjct: 218 K 218


>UniRef50_A3WPS6 Predicted pyrophosphatase MazG n=2 Tax=Idiomarina
           RepID=A3WPS6_9GAMM
          Length = 259

 Score = 66.9 bits (162), Expect = 4e-10,   Method: Composition-based stats.
 Identities = 13/72 (18%), Positives = 26/72 (36%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                + +     EE  E   A    DR  + +E  DL+    ++  +  ++   D   +
Sbjct: 27  LKQTFESLLPYTIEETYEVVDAINGGDRAAMKDELGDLLFQVVFYAQLGEEEGSFDFEAI 86

Query: 195 ----IENLRKRH 202
                + L +RH
Sbjct: 87  AQHTADKLIRRH 98


>UniRef50_Q0F926 Phosphoribosyl-ATP pyrophosphatase n=5 Tax=Rhodobacterales
           RepID=Q0F926_9RHOB
          Length = 105

 Score = 66.9 bits (162), Expect = 4e-10,   Method: Composition-based stats.
 Identities = 33/90 (36%), Positives = 56/90 (62%)

Query: 113 LFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNE 172
             L +L Q +  RK+   E SY ++L  SG+++ A+K GEE VE  +AA   D+  LT E
Sbjct: 3   DILIRLAQTIENRKNGGDEKSYVSELIQSGSEKCAEKFGEEAVEAIIAAAKRDKKNLTEE 62

Query: 173 ASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
           ++D+++H+LV+L    +D  +V++ L +R 
Sbjct: 63  SADVLFHMLVMLSSCDVDFKSVLKELERRE 92


>UniRef50_A9AYB5 MazG family protein n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9AYB5_HERA2
          Length = 381

 Score = 66.5 bits (161), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  ET  A    D   L  E  DL+    +H     Q    +L  V 
Sbjct: 148 KQTHASLREFLLEETHETLEALDAEDWPNLKEELGDLLLQIVFHAEFGRQAGRFNLDQVY 207

Query: 196 ----ENLRKRH 202
                 L +RH
Sbjct: 208 TAINSKLIRRH 218


>UniRef50_A1SF64 MazG nucleotide pyrophosphohydrolase n=1 Tax=Nocardioides sp. JS614
           RepID=A1SF64_NOCSJ
          Length = 233

 Score = 66.5 bits (161), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 16/74 (21%), Positives = 28/74 (37%), Gaps = 12/74 (16%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDR----FELTNEASDLM----YHLLVLLQDQGLDLT 192
              + +A+ + EE  ET  A    DR      L  E  DL+    +H ++  +     L 
Sbjct: 34  QTHRSLARFLLEETHETLEAIDDGDRTGDWSHLREELGDLLLQVYFHAVIAEETGEFTLD 93

Query: 193 TVIE----NLRKRH 202
            V       + +R+
Sbjct: 94  DVARDITAKMHRRN 107


>UniRef50_B1J1L8 MazG family protein n=14 Tax=Bacteria RepID=B1J1L8_PSEPW
          Length = 277

 Score = 66.5 bits (161), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV 194
                  I     EE  E A      D   L  E  DL+    Y+  +  ++   +   V
Sbjct: 26  LKQNYASIVAHTIEEAYEVADTIERGDFEHLQGELGDLLFQVVYYSQLAREEGRFEFDGV 85

Query: 195 I----ENLRKRH 202
           +      L +RH
Sbjct: 86  VDAITRKLIRRH 97



 Score = 45.3 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 23/62 (37%), Gaps = 4/62 (6%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRKR 201
           +  KV EE  E   A    D   L +E  DL++  + L +    D    +        +R
Sbjct: 177 VLDKVREELDEVLQAMADGDAEALEDEVGDLLFAAVNLARHLKQDPENALRRANRKFERR 236

Query: 202 HQ 203
            +
Sbjct: 237 FR 238


>UniRef50_Q8NRS5 Predicted pyrophosphatase n=4 Tax=Corynebacterium
           RepID=Q8NRS5_CORGL
          Length = 195

 Score = 66.5 bits (161), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 11/68 (16%), Positives = 24/68 (35%), Gaps = 4/68 (5%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D   + +E  D    +++H  +  +    D+  V 
Sbjct: 89  TQTHESLIPYLEEESQEFIEAIHGGDDEHMKSELGDVLLQVLFHAEIAARQGRFDIFDVA 148

Query: 196 ENLRKRHQ 203
            +   + Q
Sbjct: 149 ASFVAKMQ 156


>UniRef50_A4F800 Transcriptional regulator, MazG family n=4 Tax=Actinomycetales
           RepID=A4F800_SACEN
          Length = 334

 Score = 66.5 bits (161), Expect = 5e-10,   Method: Composition-based stats.
 Identities = 14/73 (19%), Positives = 23/73 (31%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQG--LDLTT 193
                 + + + EE  E   A    DR  L  E  D    +++H  +  +       +  
Sbjct: 125 EQDHDTLRKYLVEETYELLDAIEQRDRDALREELGDVLLQVLFHARIAAEHDADPFGVDE 184

Query: 194 VIEN----LRKRH 202
           V       L  RH
Sbjct: 185 VAAELVSKLVSRH 197


>UniRef50_D1YB63 MazG family protein n=2 Tax=Propionibacterium acnes
           RepID=D1YB63_PROAC
          Length = 212

 Score = 66.1 bits (160), Expect = 7e-10,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
           +   + +   + EE  E   A       +L  E  DL+    +H  +  Q    D+  V 
Sbjct: 31  SQTHRSLVTYLVEETGEVIDAIEAGTDDDLVEELGDLLLQVVFHSRIGEQGGRFDINEVV 90

Query: 195 ---IENLRKRH 202
              +  L  RH
Sbjct: 91  GGIVAKLVARH 101


>UniRef50_Q1J066 MazG family protein n=5 Tax=Deinococci RepID=Q1J066_DEIGD
          Length = 210

 Score = 66.1 bits (160), Expect = 7e-10,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 24/71 (33%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A +      L  E  D++    +H ++  ++       V 
Sbjct: 22  KQTHESLRPYLLEEAAEAVDAVSEG-PAALAGELGDVLLQVAFHAVIAEEEGTFTYADVE 80

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 81  RGIVEKLIRRH 91


>UniRef50_B5YFB4 MazG n=2 Tax=Dictyoglomus RepID=B5YFB4_DICT6
          Length = 258

 Score = 66.1 bits (160), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVI 195
               + +     EE  E   A   +D+  +  E  D++ H+L    +  +    +   V 
Sbjct: 30  KQTPQTLIPYFLEEAYELIDALEKNDQEMIKEELGDILLHVLMQSIMAEEKNRFNFEEVC 89

Query: 196 E----NLRKRH 202
           +     L  RH
Sbjct: 90  KNLKVKLITRH 100



 Score = 47.6 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 12/57 (21%), Positives = 27/57 (47%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             +K I  K+ EE  E   A    ++ ++  E  DL++ ++ + +  G+D  + +  
Sbjct: 161 KNSKEIIPKLYEELKELEKAIQEDNKEDMEEEIGDLLFTIVNIARHLGIDPESSLRK 217


>UniRef50_P0AEY4 Protein mazG n=179 Tax=Proteobacteria RepID=MAZG_ECO57
          Length = 263

 Score = 65.7 bits (159), Expect = 9e-10,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 IA    EE  E   A    D  +L  E  DL+    ++  +  ++   D   + 
Sbjct: 26  EQTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDIC 85

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 86  AAISDKLERRH 96


>UniRef50_B2GM14 Putative uncharacterized protein n=1 Tax=Kocuria rhizophila DC2201
           RepID=B2GM14_KOCRD
          Length = 364

 Score = 65.7 bits (159), Expect = 9e-10,   Method: Composition-based stats.
 Identities = 17/79 (21%), Positives = 30/79 (37%), Gaps = 16/79 (20%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHD-----RFELTNEASDLM----YHLLVLLQD---Q 187
               + + + + EE  E   A    +     R EL  E  D++    +H  +  +    Q
Sbjct: 74  EQTHESLLRYLVEESYEVVEAVEALEPSQRRRDELVEELGDVLLQVVFHARIGQEHPQPQ 133

Query: 188 GLDLTTVIE----NLRKRH 202
             D+T V+      L +RH
Sbjct: 134 RFDVTDVLAAVTDKLVRRH 152


>UniRef50_C0Q9D5 Tetrapyrrole methylase family protein (MazG family protein) n=1
           Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0Q9D5_DESAH
          Length = 273

 Score = 65.7 bits (159), Expect = 1e-09,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL----QDQGLDLTTVI 195
               + + + + EE  E   A    D  ++ +E  D+++ L+ +     +    D+   I
Sbjct: 34  KQTPETMWKCLIEEVYELLEAIEKDDAADVCDELGDVLFQLVFIAELYRERGAFDIFDAI 93

Query: 196 ----ENLRKRH 202
               + + +RH
Sbjct: 94  SKSAQKMIRRH 104



 Score = 41.1 bits (95), Expect = 0.027,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 27/62 (43%), Gaps = 4/62 (6%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----NLRKR 201
           + +KV EE  E   A    D+ E+  E  D+++ L  + +  G+   T +        +R
Sbjct: 176 VIEKVEEEWKEFTQALATGDKDEIAMEFGDILFTLSNVARFAGIHPETALARSTEKFEQR 235

Query: 202 HQ 203
            +
Sbjct: 236 FR 237


>UniRef50_Q5HIH0 Tetrapyrrole methylase family protein n=63 Tax=Staphylococcaceae
           RepID=Q5HIH0_STAAC
          Length = 397

 Score = 65.3 bits (158), Expect = 1e-09,   Method: Composition-based stats.
 Identities = 13/70 (18%), Positives = 28/70 (40%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI- 195
              + + + + EE  E   A    D + +  E  D    ++ H  +  ++  +D+  VI 
Sbjct: 258 QTHETLKRYLLEETFELFEAIDNEDDWHMIEELGDILLQVLLHTSIGKKEGYIDIKEVIT 317

Query: 196 ---ENLRKRH 202
                + +RH
Sbjct: 318 SLNAKMIRRH 327


>UniRef50_D2S938 MazG family protein n=1 Tax=Geodermatophilus obscurus DSM 43160
           RepID=D2S938_9ACTO
          Length = 309

 Score = 65.3 bits (158), Expect = 1e-09,   Method: Composition-based stats.
 Identities = 13/74 (17%), Positives = 24/74 (32%), Gaps = 11/74 (14%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQD---QGLDLT 192
                 +   + EE  E   A    D   +  E  D++    +H  V  +    +   + 
Sbjct: 114 EQTHASLRGYLLEEAHEAYDAIVDDDAAGMREELGDVLLQVVFHARVAAEADPSRRFTVD 173

Query: 193 TVI----ENLRKRH 202
            V     + L +RH
Sbjct: 174 DVAGDLVDKLVRRH 187


>UniRef50_C8WQS0 MazG family protein n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WQS0_ALIAD
          Length = 493

 Score = 64.9 bits (157), Expect = 1e-09,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNE----ASDLMYHLLVLLQDQGLDLTTV- 194
                 + + V EE  E A A    D   L  E       ++ H  +  +     L  V 
Sbjct: 254 KQTHASLRKYVVEEAYEVAEAIDEGDADHLAEELGDLLLQILLHARIAEEAGEFTLRDVF 313

Query: 195 ---IENLRKRH 202
                 L +RH
Sbjct: 314 AGLAAKLVRRH 324


>UniRef50_Q30YJ6 MazG family protein n=6 Tax=Desulfovibrionales RepID=Q30YJ6_DESDG
          Length = 268

 Score = 64.9 bits (157), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLT--- 192
               + +   V EE  E   A    +  ++  E  D+M+ +     +     G  L    
Sbjct: 31  EQTPESLCDYVLEEAFELVDAIRSGNAADVREELGDVMFLMAFIGRLYQDRAGFSLEDAV 90

Query: 193 -TVIENLRKRH 202
             V   + +RH
Sbjct: 91  ADVAAKMVRRH 101


>UniRef50_C1A8D0 Putative nucleoside triphosphate pyrophosphohydrolase n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1A8D0_GEMAT
          Length = 270

 Score = 64.9 bits (157), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 15/70 (21%), Positives = 24/70 (34%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTV-- 194
                +   + EE  E   A    D   L +E  DL    ++H +V  +     +  V  
Sbjct: 41  QTHASLRPYLIEEAHEVDDAIAQGDDAVLRDELGDLFLQVLFHSVVAEERGAFGMQDVAG 100

Query: 195 --IENLRKRH 202
             I  +  RH
Sbjct: 101 ALIAKMHARH 110


>UniRef50_D1W9A9 MazG family protein n=5 Tax=Prevotella RepID=D1W9A9_9BACT
          Length = 294

 Score = 64.9 bits (157), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV- 194
               + +     EE  E   A    D+  +  E  D+M H+L    +  +    DL  V 
Sbjct: 41  KQTNESLRPNTIEEVYELCDALLNDDKKNICKELGDVMEHVLFYSILGEETHDFDLADVC 100

Query: 195 ---IENLRKRH 202
               + L  RH
Sbjct: 101 NKQADKLMFRH 111


>UniRef50_C7RAH4 MazG family protein n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAH4_KANKD
          Length = 266

 Score = 64.5 bits (156), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I     EE  E A A    D  EL  E  DL+    ++  +  ++   D  ++ 
Sbjct: 35  KQTYETIVPYTLEEAYEVADAIERGDFEELHGELGDLLFQVIFYAQIGQEEGRFDFESIA 94

Query: 196 E----NLRKRH 202
           E     L  RH
Sbjct: 95  EKVSNKLVSRH 105



 Score = 47.6 bits (112), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 12/61 (19%), Positives = 26/61 (42%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
              + +KV EE  E   A   +D+  +  E  DL++  + L +   +D    +    ++ 
Sbjct: 173 VSGVIEKVEEEIAELKQAIANNDQQNIEEEIGDLLFSCVNLSRHLKVDAEAALRKSSRKF 232

Query: 203 Q 203
           +
Sbjct: 233 E 233


>UniRef50_Q3B1B2 MazG n=12 Tax=Chlorobiaceae RepID=Q3B1B2_PELLD
          Length = 285

 Score = 64.5 bits (156), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH----LLVLLQDQGLDLTTVI 195
               + +A  + EE  E   A   +D  EL  E  DL  H      +  +        V+
Sbjct: 45  KQTPQSLAHLLLEESYELVDAIDGNDDEELKKELGDLFLHVCFQAELGEESGKFTFNEVM 104

Query: 196 ----ENLRKRH 202
                 L  RH
Sbjct: 105 DGLSRKLIHRH 115


>UniRef50_A8UAP0 Putative uncharacterized protein n=1 Tax=Carnobacterium sp. AT7
           RepID=A8UAP0_9LACT
          Length = 351

 Score = 64.5 bits (156), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 18/71 (25%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D   +  E  DL    +YH     Q        VI
Sbjct: 250 EQTHQTLLAYLDEEVREFKTAVENDDSDNMVEELGDLLMQVLYHTNFGEQSGYFSFEEVI 309

Query: 196 E----NLRKRH 202
           E     LR+RH
Sbjct: 310 ETLNKKLRRRH 320


>UniRef50_C6CRL2 MazG family protein n=6 Tax=Firmicutes RepID=C6CRL2_PAESJ
          Length = 492

 Score = 64.2 bits (155), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I +   EE  E   A    D   +  E  D++     H  +  +     +  VI
Sbjct: 257 EQTHQSIRKNFIEELYEALEAIDNDDPDNMREEFGDVILQVMLHSQMEEETGAFSVYDVI 316

Query: 196 ----ENLRKRH 202
               E L  RH
Sbjct: 317 EGLNEKLIFRH 327


>UniRef50_B7H015 MazG family protein n=18 Tax=Acinetobacter RepID=B7H015_ACIB3
          Length = 268

 Score = 64.2 bits (155), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + +   EE  E   A    D  E+ NE  DL+    +   +  +    +   V+
Sbjct: 20  EQTPMSLTKYAIEEAYEVEAAIRQGDINEIRNELGDLLLQVVFQSQMFSEQGAFNFQDVV 79

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 80  EAISEKLVRRH 90


>UniRef50_UPI000197392B MazG family protein n=1 Tax=Clostridium sp. M62/1
           RepID=UPI000197392B
          Length = 152

 Score = 64.2 bits (155), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 13/70 (18%), Positives = 23/70 (32%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI- 195
              + +   V EE  E   A    D   L  E  DL+    ++  +  +        V+ 
Sbjct: 44  QTFESMVSCVTEEAKEVVQAVKQQDMDNLCEELGDLLFQVVFYSQMAQEQGLFTFEQVVD 103

Query: 196 ---ENLRKRH 202
                + +RH
Sbjct: 104 GISAKMVRRH 113


>UniRef50_C8WMR5 Phosphoribosyl-ATP diphosphatase n=1 Tax=Eggerthella lenta DSM 2243
           RepID=C8WMR5_EGGLE
          Length = 163

 Score = 63.8 bits (154), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 29/114 (25%), Positives = 40/114 (35%), Gaps = 34/114 (29%)

Query: 122 LAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDR--------------- 166
               +    E SYT +L       + +KV EE  ETALAA   +                
Sbjct: 28  TIAARREAGEESYTYRLLTGSLDGVLKKVMEEAGETALAAKDVESWACSSLAASIAASGA 87

Query: 167 -------------------FELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
                                L  EA+D++YHLLV+L+  G+ L      L  R
Sbjct: 88  VDETDELAVDLPPEYDAAIDHLRYEAADVVYHLLVVLERYGIGLDEFAAELNNR 141


>UniRef50_Q2LVG8 MazG-like domain protein n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVG8_SYNAS
          Length = 273

 Score = 63.8 bits (154), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH----LLVLLQDQGLDLTTVI 195
               + I + + +E  E   A       +L  E  DL++       +  +     +  V+
Sbjct: 38  QQKKEDIGRYLLDESYEVLDAVASGGSEDLKEELGDLLFQILFLAQIAEESGEFGIADVL 97

Query: 196 EN----LRKRH 202
           E     + +RH
Sbjct: 98  EEVTAKMIRRH 108



 Score = 40.7 bits (94), Expect = 0.034,   Method: Composition-based stats.
 Identities = 14/47 (29%), Positives = 21/47 (44%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           +  K+ EE  E   A    DR  +T E  DL + L+ L +   +D  
Sbjct: 178 VIAKIEEELDELKAAIRTGDREHITEETGDLFFSLVNLCRFFSMDAE 224


>UniRef50_D2RLM3 MazG family protein n=1 Tax=Acidaminococcus fermentans DSM 20731
           RepID=D2RLM3_ACIFE
          Length = 270

 Score = 63.8 bits (154), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 11/70 (15%), Positives = 27/70 (38%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLD----LT 192
              + + +++ EE  E   A    +   +  E  D++    +H  +  ++        + 
Sbjct: 39  QTHQSMRRELVEEVYEMLEAIDDGNVAGMREEMGDVLLQVVFHARLAEEEGLFAMQDVID 98

Query: 193 TVIENLRKRH 202
            V++ L  RH
Sbjct: 99  DVVKKLVHRH 108



 Score = 41.1 bits (95), Expect = 0.023,   Method: Composition-based stats.
 Identities = 14/51 (27%), Positives = 18/51 (35%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
                 +KV EE  E   A    DR     E  DL + L V  +   L+  
Sbjct: 171 DAPSAWEKVQEEEKELQEAVEACDRDRTEEELGDLFFALAVYARKLDLEPE 221


>UniRef50_A2BTR6 MazG family protein n=7 Tax=Prochlorococcus marinus
           RepID=A2BTR6_PROMS
          Length = 284

 Score = 63.4 bits (153), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 20/112 (17%), Positives = 39/112 (34%), Gaps = 9/112 (8%)

Query: 100 GTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYA-SGTKRIAQKVGEEGVETA 158
            +++ +    +  L      ++L     A  + S+            +   + EE  E  
Sbjct: 2   SSNNRYKLEKNSDLETINSFKILISNIKALKDKSWGCPWQKIQSHISLIPFLYEESNEFI 61

Query: 159 LAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVIENLRK----RH 202
            A    +   +  E  DL+     H  +  +++   L  VI+NL K    RH
Sbjct: 62  DAIYEKNAVNICEELGDLLLQVMLHSEIGYEEKEFTLNDVIKNLNKKIIYRH 113



 Score = 41.8 bits (97), Expect = 0.015,   Method: Composition-based stats.
 Identities = 13/54 (24%), Positives = 24/54 (44%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             I +K+ EE  E   A    +  E+ NE  D+ + LL L     ++  + ++ 
Sbjct: 184 DEIFKKLEEEINELKEAIKSKNDSEIKNEFGDIYFTLLNLSNFLKINPESALQK 237


>UniRef50_Q6AK03 Putative uncharacterized protein n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AK03_DESPS
          Length = 145

 Score = 63.4 bits (153), Expect = 5e-09,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL----LQDQGLDLTTVI 195
               + I + +  E  E   A    D   +  E  D++Y ++++     ++    L  V 
Sbjct: 30  KQTNESIIKYLKSESQELIDALEKKDYPNICEELGDVLYIVILISSINKKEGQFSLEDVF 89

Query: 196 EN----LRKRH 202
                 L +RH
Sbjct: 90  REVNAKLVRRH 100


>UniRef50_B8G6I9 MazG family protein n=3 Tax=Chloroflexus RepID=B8G6I9_CHLAD
          Length = 408

 Score = 63.4 bits (153), Expect = 5e-09,   Method: Composition-based stats.
 Identities = 15/70 (21%), Positives = 22/70 (31%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMY----HLLVLLQDQGLDLT---- 192
              + + +   EE  E   A    D   L  E  D++     H  +  Q     L     
Sbjct: 165 QTHQSLRRTFLEEVYEALEAIDTGDMRHLCEELGDVLMQVFVHSEMARQAGYFTLESVVQ 224

Query: 193 TVIENLRKRH 202
            V + L  RH
Sbjct: 225 HVADKLIFRH 234



 Score = 40.3 bits (93), Expect = 0.043,   Method: Composition-based stats.
 Identities = 14/62 (22%), Positives = 24/62 (38%), Gaps = 3/62 (4%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
             +++  K+ EE  E   A    D      E  DL++ L +L     LD  + +     R
Sbjct: 301 TIEQVWAKIAEELAELREA---DDSAAQKRELGDLLFALTILAHWLQLDAESALREANLR 357

Query: 202 HQ 203
            +
Sbjct: 358 FK 359


>UniRef50_A6C1Y3 MazG family protein n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C1Y3_9PLAN
          Length = 312

 Score = 63.0 bits (152), Expect = 5e-09,   Method: Composition-based stats.
 Identities = 18/119 (15%), Positives = 32/119 (26%), Gaps = 8/119 (6%)

Query: 92  PIGPTCHKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVG 151
              P    G           +  L    + L +  +                + I     
Sbjct: 7   QSQPAGPTGAGDPLPGIPPDYSILTPAFEKLCDVIARLRSPEGCPWDREQTLETIKPYTL 66

Query: 152 EEGVETALAATVHDRFELTNEASDLMYH----LLVLLQDQGLDLTTVIE----NLRKRH 202
           EE  E   A    +   +  E  DL+        +   +   DLT V++     + +RH
Sbjct: 67  EETYELLEAIDSGNDEHIIEELGDLLLQIVLDAQIAADEGRFDLTHVVDRLTQKMIERH 125


>UniRef50_C1YI03 MazG family protein n=1 Tax=Nocardiopsis dassonvillei subsp.
           dassonvillei DSM 43111 RepID=C1YI03_NOCDA
          Length = 265

 Score = 63.0 bits (152), Expect = 6e-09,   Method: Composition-based stats.
 Identities = 18/113 (15%), Positives = 34/113 (30%), Gaps = 20/113 (17%)

Query: 103 SCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT 162
              G        L  +E +   R+    +              +A+ + +E  ET     
Sbjct: 16  GRDGGPPVGHRVLRLVEVMDTLRRECPWDR-------DQTHGSLAKYLIQEAYETLETIE 68

Query: 163 VHDRFELTNEASDLM----YHLLVLLQD-----QGLDLTTV----IENLRKRH 202
             D   L  E  D++    +H  V  +          +  V    I+ + +RH
Sbjct: 69  EGDFALLREELGDVLLQVVFHAAVAAERPEGDPARFTVDDVADAIIDKMTRRH 121


>UniRef50_Q65VQ2 MazG protein n=1 Tax=Mannheimia succiniciproducens MBEL55E
           RepID=Q65VQ2_MANSM
          Length = 234

 Score = 62.2 bits (150), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 13/65 (20%), Positives = 22/65 (33%), Gaps = 8/65 (12%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV----IEN 197
           +   + EE  E   A    +  +L  E  DL+    +   +  ++       V     E 
Sbjct: 1   MIPCLIEESYEVVEAIQQKNTADLREELGDLLMQVVFLSQLAAEENKFTFDDVVNDIAEK 60

Query: 198 LRKRH 202
           L  RH
Sbjct: 61  LIYRH 65


>UniRef50_C7M0K4 MazG nucleotide pyrophosphohydrolase n=1 Tax=Acidimicrobium
           ferrooxidans DSM 10331 RepID=C7M0K4_ACIFD
          Length = 430

 Score = 62.2 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 18/76 (23%), Positives = 30/76 (39%), Gaps = 13/76 (17%)

Query: 140 ASGTKRIAQKVGEEGVETALA-----ATVHDRFELTNEASDLMY----HLLVLLQDQGLD 190
           +   + +A+ + EE  E   A     A  HDR  +  E  D++     H  +  +D   D
Sbjct: 243 SQTHRSLARHLIEEAYEAVDALDAYEADGHDRDHVVEELGDVLLQVLMHATIADEDGSFD 302

Query: 191 LTTVIE----NLRKRH 202
           L  +       L +RH
Sbjct: 303 LIAIARALTDKLIRRH 318


>UniRef50_A0LC99 MazG family protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LC99_MAGSM
          Length = 277

 Score = 62.2 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTT-- 193
               + +     EE  E   A    D  EL  E  DL++H+     +  +     L    
Sbjct: 40  EQSFQSLLPYTLEEVYEVLHAVETQDHQELKKELGDLLFHIVFYSQIAAEANQFTLEQVV 99

Query: 194 --VIENLRKRH 202
             V++ +  RH
Sbjct: 100 NSVVQKMLHRH 110



 Score = 46.1 bits (108), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 16/55 (29%), Positives = 25/55 (45%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            T  I  K+ EE  E A A   +DR     E  DL++ L+ L +   ++  T + 
Sbjct: 179 DTDGILDKIREEIDELAQARAENDRAGQKEELGDLLFALVNLARRLEIEPETALR 233


>UniRef50_C5VBE9 Nucleoside triphosphate pyrophosphohydrolase n=2
           Tax=Corynebacterium matruchotii RepID=C5VBE9_9CORY
          Length = 226

 Score = 62.2 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVH-DRFELTNEASD----LMYHLLVLLQDQGLDLTTV 194
               + +   + EE  E A A T   D  EL  E  D    +++H  +  +    D   V
Sbjct: 120 EQTHETLLPYLREETTELAEAITTRADDAELMAELGDVLLQVLFHAEIAARRGAFDFGDV 179

Query: 195 ----IENLRKR 201
               I  +R+R
Sbjct: 180 VGSFIGKMRRR 190


>UniRef50_Q6MDA8 Putative uncharacterized protein n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MDA8_PARUW
          Length = 217

 Score = 62.2 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 30/71 (42%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTVI 195
               + +   V EE  E   A  + +  ++  E  DL ++++    +  +D+   L  ++
Sbjct: 25  EQTLQSMRSSVIEEVYELVEAIDLENNEKIKEELGDLCFNVIFLGKLAERDKKFSLHDML 84

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 85  KEINEKLIRRH 95


>UniRef50_B8FGV8 MazG family protein n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FGV8_DESAA
          Length = 266

 Score = 62.2 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL----LQDQGLDLTTVI 195
               + +   + EE  E   A    +      E  D+++H+  L     +        V 
Sbjct: 33  KQTPESMRVYLVEEMYELLDALESDEPSAALEELGDVLFHVFFLSCMFEERGEFTAMDVA 92

Query: 196 ----ENLRKRH 202
               E +  RH
Sbjct: 93  KANTEKMIARH 103


>UniRef50_Q6MMY5 Tetrapyrrole methylase family protein/MazG family protein n=1
           Tax=Bdellovibrio bacteriovorus RepID=Q6MMY5_BDEBA
          Length = 294

 Score = 62.2 bits (150), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 14/76 (18%), Positives = 24/76 (31%), Gaps = 13/76 (17%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFE-----LTNEASDLMY----HLLVLLQDQGLD 190
               + + Q   EE  E   A  +          +  E  D+++    H  +  +     
Sbjct: 54  EQTHESLTQYAIEETHELVEALELPASDASKDLKMKEELGDVLFQVVLHAQLAAERGAFT 113

Query: 191 LTTVIE----NLRKRH 202
           L  VI      L +RH
Sbjct: 114 LEDVIAGISEKLVRRH 129



 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 12/63 (19%), Positives = 24/63 (38%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
                +   V EE  E   A    +  E+ +E  D ++ L  L +   ++   V+    +
Sbjct: 193 EDMDGVLANVEEEYQELREALDEGNDSEIEHELGDALFSLAQLGRHVQMEPEQVLRKANQ 252

Query: 201 RHQ 203
           R +
Sbjct: 253 RFE 255


>UniRef50_Q2SL25 Predicted pyrophosphatase n=20 Tax=Proteobacteria
           RepID=Q2SL25_HAHCH
          Length = 288

 Score = 61.9 bits (149), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 15/72 (20%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTT- 193
                  I     EE  E A A    D   L +E  DL+    ++  +  +         
Sbjct: 34  LKQDFASIVPFTIEETYEVADAIEREDWPHLRDELGDLLFQAVFYSQLAQEKDLFQWPDI 93

Query: 194 ---VIENLRKRH 202
              V+  L +RH
Sbjct: 94  VDGVVRKLLRRH 105


>UniRef50_P33653 Uncharacterized 26.1 kDa protein in blaB 3'region n=3
           Tax=Actinomycetales RepID=YBL1_STRCI
          Length = 242

 Score = 61.9 bits (149), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 23/72 (31%), Gaps = 10/72 (13%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTTV 194
                + +   EE  E   A    DR EL  E  D++    +H  +   D      +  V
Sbjct: 63  RTHHDLVKYGVEEMYELVDAIEAGDRGELREELGDVLLQVVFHARIAQDDADEPFAIDDV 122

Query: 195 IE----NLRKRH 202
                  L  RH
Sbjct: 123 AGTLVTKLVHRH 134


>UniRef50_Q1NJI5 MazG nucleotide pyrophosphohydrolase n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NJI5_9DELT
          Length = 130

 Score = 61.9 bits (149), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 13/70 (18%), Positives = 24/70 (34%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTVI- 195
              +     + EE  E   A    +   +  E  DL++ +     +  + Q   L  VI 
Sbjct: 32  QTPETFKGYLLEEAHELMEALEGDNPEHIREELGDLLFQIIFLSQLYSERQEFTLAEVID 91

Query: 196 ---ENLRKRH 202
                + +RH
Sbjct: 92  GIRAKMIRRH 101


>UniRef50_A8LHV5 MazG family protein n=9 Tax=Proteobacteria RepID=A8LHV5_DINSH
          Length = 279

 Score = 61.5 bits (148), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
               + IA    EE  E + A    D  +L +E  DL+    Y   +  +    D   V 
Sbjct: 45  EQTFETIAPYTIEEAYEVSDAIDRGDWADLKSELGDLLLQTVYQTQIGAERGLFDFHDVA 104

Query: 195 ---IENLRKRH 202
               + +  RH
Sbjct: 105 NGIAQKMLDRH 115


>UniRef50_B9KZD8 Putative tetrapyrrole (Corrin/porphyrin) methylases n=1
           Tax=Thermomicrobium roseum DSM 5159 RepID=B9KZD8_THERP
          Length = 456

 Score = 61.1 bits (147), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTT-- 193
               + + + + EE  E   A    D   L  E  D++     H  +  +          
Sbjct: 263 EQTHQSLRRYLLEETYEALDAIEEDDDDALCEELGDVLLQVILHAQIAEERGAFVYEDVV 322

Query: 194 --VIENLRKRH 202
             VIE L +RH
Sbjct: 323 GTVIEKLVRRH 333


>UniRef50_C0CMG7 Putative uncharacterized protein n=1 Tax=Blautia hydrogenotrophica
           DSM 10507 RepID=C0CMG7_9FIRM
          Length = 139

 Score = 61.1 bits (147), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 11/75 (14%), Positives = 23/75 (30%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAAT----VHDRFELTNEASDLM----YHLLVLLQDQGLDL 191
               + +   + EE  E            +   L  E  D++     H ++  ++    L
Sbjct: 28  TQTHESLKVCMEEEASEVIEGIDLLKSTGEWDNLCEELGDVLLQVVLHSVIAQEEGLFTL 87

Query: 192 TTV----IENLRKRH 202
             V       + +RH
Sbjct: 88  EDVVTGIARKMVRRH 102


>UniRef50_A5ZV93 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC
           29174 RepID=A5ZV93_9FIRM
          Length = 133

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 12/74 (16%), Positives = 27/74 (36%), Gaps = 12/74 (16%)

Query: 141 SGTKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLMY----HLLVLLQDQGLDLT 192
              + + + + EE  E           +D   L  E  D+++    H ++  ++    + 
Sbjct: 24  QTHESLKKYLLEESNEVLEGIDRLSKENDSTNLCEELGDVLFQVALHSVIAEEEGLFTVE 83

Query: 193 TVIE----NLRKRH 202
            VI      ++ RH
Sbjct: 84  DVIRDVSSKMKFRH 97


>UniRef50_Q6I858 Predicted MazG-family transcriptional regulator n=1
           Tax=Aeromicrobium erythreum RepID=Q6I858_9ACTO
          Length = 199

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 17/72 (23%), Positives = 27/72 (37%), Gaps = 9/72 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQ-GLDLTTV 194
               + +++ + EE  ET  A    D   L  E  DL+    +H  V      G D+  V
Sbjct: 29  QQTHESLSRYLLEETYETLEALDDGDTDLLREELGDLLMQVVFHAAVAADTGEGWDVDDV 88

Query: 195 IE----NLRKRH 202
                  L +R+
Sbjct: 89  AAGITDKLVRRN 100


>UniRef50_A5CTB1 Putative pyrophosphatase n=4 Tax=Actinobacteria (class)
           RepID=A5CTB1_CLAM3
          Length = 254

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 14/70 (20%), Positives = 26/70 (37%), Gaps = 9/70 (12%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQ-GLDLTTVIE 196
             + +   + EE  E   A    D   +  E +D++    +H  +   +  G DL  V  
Sbjct: 46  THRTLVPYLLEESHELVEAIETDDVPGMREELADVLLQVVFHADIARTEGEGFDLADVAR 105

Query: 197 ----NLRKRH 202
                + +RH
Sbjct: 106 TATEKMVRRH 115


>UniRef50_C1ZK38 MazG family protein n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZK38_PLALI
          Length = 320

 Score = 60.7 bits (146), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH----LLVLLQDQGLDLTTVI 195
               K + +   EE  E   A    D   +  E  D++        +   +Q  DL  VI
Sbjct: 61  EQTLKSVCKHTLEETYELIEAIEHDDNIAIVEELGDVLLQVILDAQIGRDEQRFDLIDVI 120

Query: 196 E----NLRKRH 202
                 +  RH
Sbjct: 121 RGVTAKMIHRH 131


>UniRef50_C3JX00 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Rhodococcus
           erythropolis SK121 RepID=C3JX00_RHOER
          Length = 316

 Score = 60.3 bits (145), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 16/77 (20%), Positives = 28/77 (36%), Gaps = 7/77 (9%)

Query: 132 TSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLL--- 184
            S+     A   + ++  + EE  E   A    DR  L  E  DL    ++H  +     
Sbjct: 102 WSFGGWEVAQTHESLSNYLLEETYEVLDAILAGDREALNEELGDLLLQVLFHARIAECEP 161

Query: 185 QDQGLDLTTVIENLRKR 201
               +D+ T+   L  +
Sbjct: 162 TAPPVDIDTIAGALVAK 178


>UniRef50_C2AVJ2 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Tsukamurella paurometabola DSM 20162
           RepID=C2AVJ2_TSUPA
          Length = 321

 Score = 60.3 bits (145), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 25/142 (17%), Positives = 42/142 (29%), Gaps = 28/142 (19%)

Query: 82  DNDTLLVLANPIGPTC----HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAK 137
             D ++V ++P  P        G     G        L  +  +   R     E+     
Sbjct: 55  PADAVIVSSDPEHPAVVTLRAAGADVITGRRPAGLDVLDAVALIDTLRTVGPWES----- 109

Query: 138 LYASGTKRIAQKVGEEGVETALAA------TVHD--RFELTNEASDLM----YHLLVLLQ 185
                   + + + EE  E A A          D  R EL +E  DL+    +H  +  +
Sbjct: 110 --EQTHASLLRYLVEETYELADAVSALETSESGDAERAELRSELGDLLLQVIFHARIAQE 167

Query: 186 DQG--LDLTTVIENL---RKRH 202
                  +  V   L    +R 
Sbjct: 168 ASRGPFGIDEVARTLTAKVRRR 189


>UniRef50_A9WKS6 MazG n=1 Tax=Renibacterium salmoninarum ATCC 33209
           RepID=A9WKS6_RENSM
          Length = 201

 Score = 60.3 bits (145), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 11/69 (15%), Positives = 24/69 (34%), Gaps = 9/69 (13%)

Query: 143 TKRIAQKVGEEGVETALAATVH-DRFELTNEASDLM----YHLLVLLQDQGLDLTTVIE- 196
            + + + + EE  E   A        EL  E  D++     H  +  +     +  V+  
Sbjct: 27  HESLIEYLIEESYEVVEAIEAGKTPAELRGELGDVLLQVVLHARIAEESGQFVIDDVVRG 86

Query: 197 ---NLRKRH 202
               + +R+
Sbjct: 87  LTEKMTRRN 95


>UniRef50_Q027H8 MazG family protein n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q027H8_SOLUE
          Length = 263

 Score = 59.9 bits (144), Expect = 5e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 I     EE  E   A       EL  E  D M    ++  +  + +   +   +
Sbjct: 31  EQTFDTIKPYTLEETYEVLDAIDRRQWDELAEELGDFMLQAVFYAQMAAEQKLFRIDDAL 90

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 91  DAINEKLVRRH 101


>UniRef50_A0JU20 MazG family protein n=3 Tax=Arthrobacter RepID=A0JU20_ARTS2
          Length = 236

 Score = 59.9 bits (144), Expect = 5e-08,   Method: Composition-based stats.
 Identities = 12/70 (17%), Positives = 24/70 (34%), Gaps = 9/70 (12%)

Query: 142 GTKRIAQKVGEEGVETALAATVH-DRFELTNEASDLM----YHLLVLLQDQGLDLTTVI- 195
             + + + + EE  E A       D  EL  E  D++     H  +  +        V+ 
Sbjct: 30  THESLVEYLLEEAFEVAETIETGADEAELRGELGDVLLQVVLHARLAEERGSFGFDDVVQ 89

Query: 196 ---ENLRKRH 202
                + +R+
Sbjct: 90  GLTAKMIRRN 99


>UniRef50_D2NPA3 Predicted pyrophosphatase n=2 Tax=Rothia mucilaginosa
           RepID=D2NPA3_9MICC
          Length = 273

 Score = 59.9 bits (144), Expect = 5e-08,   Method: Composition-based stats.
 Identities = 17/75 (22%), Positives = 27/75 (36%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFE---LTNEASDLM----YHLLVLLQD-QGLDL 191
                 + + + EE  E   A           L  E  D++    +H  +   + QG D+
Sbjct: 73  EQTHASLIRYLVEEAYEVVEAVETGGEPNMPLLREELGDVLLQVVFHSDIAAANPQGFDI 132

Query: 192 TTVIE----NLRKRH 202
             V+E     LR RH
Sbjct: 133 VQVVEGLVQKLRSRH 147


>UniRef50_C0ES56 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM
           3353 RepID=C0ES56_9FIRM
          Length = 236

 Score = 59.5 bits (143), Expect = 7e-08,   Method: Composition-based stats.
 Identities = 14/75 (18%), Positives = 23/75 (30%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLMYHL----LVLLQDQGLDL 191
           +   + +     EE  E   A        D   L  E  DL++ +     V   +    +
Sbjct: 28  SQTHESLKLYTLEEAYEVNQAVTDLTKTGDCANLKEELGDLLFQVLLQSQVAEDNGEFAI 87

Query: 192 TTVI----ENLRKRH 202
             VI      +  RH
Sbjct: 88  EDVIDGIARKMIHRH 102


>UniRef50_C4B7S4 Putative MazG family protein n=1 Tax=Desulfotignum balticum
           RepID=C4B7S4_9DELT
          Length = 266

 Score = 59.2 bits (142), Expect = 8e-08,   Method: Composition-based stats.
 Identities = 12/70 (17%), Positives = 27/70 (38%), Gaps = 8/70 (11%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQ----DQGLD----LT 192
                + + + EE  E   A    D      E  D+++ ++ +++       +     + 
Sbjct: 35  QTPVTMWKCLAEEVYELQQALAEKDLENTCEEMGDVLFQIVFIMEIFHDSGQIPMSRVMD 94

Query: 193 TVIENLRKRH 202
           TV E + +RH
Sbjct: 95  TVKEKMIRRH 104


>UniRef50_D1PFK2 MazG family protein n=3 Tax=Prevotella RepID=D1PFK2_9BACT
          Length = 317

 Score = 59.2 bits (142), Expect = 8e-08,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTTV- 194
               + +     EE  E   A    D  ++  E  D++ H++    +  +D   D+  V 
Sbjct: 37  KQTFESLRPNTIEETFELCDALMKRDYKDIKKELGDVLEHVMFYSIIGREDGEFDICDVC 96

Query: 195 ---IENLRKRH 202
               + L  RH
Sbjct: 97  NQEADKLMFRH 107


>UniRef50_C8QYT7 MazG nucleotide pyrophosphohydrolase n=1 Tax=Desulfurivibrio
           alkaliphilus AHT2 RepID=C8QYT7_9DELT
          Length = 144

 Score = 59.2 bits (142), Expect = 9e-08,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLL----QDQGLDL---- 191
               +     + EE  E   +   +D   +  E  DL++ +L +     +     L    
Sbjct: 39  KQTPESFKHYLLEEAHELHESLGGNDHRHIREELGDLLFQVLFIAELYREQGAFTLSEVI 98

Query: 192 TTVIENLRKRH 202
             +I  + +RH
Sbjct: 99  NDIIAKMVRRH 109


>UniRef50_A4A3U0 MazG nucleotide pyrophosphohydrolase family protein n=3
           Tax=Bacteria RepID=A4A3U0_9GAMM
          Length = 282

 Score = 58.8 bits (141), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTV- 194
               + I     EE  E A A    D   + +E  D++    ++  +  +       +V 
Sbjct: 30  QQTFQSIVPSTLEECYELAAAIEAGDYPHVEDELGDVLFQVVFYARLGQERGFFSFDSVV 89

Query: 195 ---IENLRKRH 202
               E L +RH
Sbjct: 90  HGLAEKLLRRH 100



 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 15/66 (22%), Positives = 26/66 (39%), Gaps = 4/66 (6%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----N 197
           G   + +KV EE  E   A    D      E  DL++ ++ L +   +D  T +      
Sbjct: 185 GVNPVLEKVDEELRELREAMAQGDPKATEEELGDLLFTVVNLSRHLKIDAETALRHASGK 244

Query: 198 LRKRHQ 203
             +R +
Sbjct: 245 FERRFR 250


>UniRef50_Q1QX16 MazG family protein n=12 Tax=Proteobacteria RepID=Q1QX16_CHRSD
          Length = 280

 Score = 58.4 bits (140), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + I     EE  E A A       EL  E  DL+    Y+     ++Q  D   V+
Sbjct: 32  KQDWQSIVPHTLEEAYEVADAIERRAFDELPGELGDLLFQVVYYSQFAREEQRFDFHDVV 91

Query: 196 ----ENLRKRH 202
                 +  RH
Sbjct: 92  DTVTAKMVARH 102


>UniRef50_Q73KD2 MazG family protein n=1 Tax=Treponema denticola RepID=Q73KD2_TREDE
          Length = 281

 Score = 58.4 bits (140), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 14/77 (18%), Positives = 29/77 (37%), Gaps = 13/77 (16%)

Query: 139 YASGTKRIAQKVGEEGVETALAATV-----HDRFELTNEASDLMYHLLVL----LQDQGL 189
            A     + + + EE  E A A         +   +  E  D++ ++L++     Q+   
Sbjct: 30  IAQTPMSMRKSLLEEAYEAADAIEEHHNTGQNAEHVKEELGDILLNVLMISYMYEQEGLF 89

Query: 190 DLTTVI----ENLRKRH 202
               ++    E L +RH
Sbjct: 90  STADIMKNLTEKLIRRH 106


>UniRef50_A0LK91 MazG family protein n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LK91_SYNFM
          Length = 229

 Score = 58.4 bits (140), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL----LQDQGLDLTTV- 194
                ++   + EE  E A A     R E   E  DL++ +  L     +     L  V 
Sbjct: 33  KQTPDKVQTYLIEEAHEAASAVRAGRREEAAEELGDLLFMVFFLIHLYEESGDFRLEEVC 92

Query: 195 ---IENLRKRH 202
               E + +RH
Sbjct: 93  DAICEKMVRRH 103


>UniRef50_B8DJD8 MazG family protein n=8 Tax=Desulfovibrionales RepID=B8DJD8_DESVM
          Length = 287

 Score = 58.0 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLTTV- 194
               + +A  V EE  E   A       ++  E  D+M+ L     +        L    
Sbjct: 35  EQTPESLADYVIEECFELVEAIRSGKVHDVREELGDVMFLLAFIGRLYADKGAFTLADAV 94

Query: 195 ---IENLRKRH 202
                 + +RH
Sbjct: 95  EGNAAKMIRRH 105


>UniRef50_Q0HXH2 MazG family protein n=140 Tax=Proteobacteria RepID=Q0HXH2_SHESR
          Length = 312

 Score = 58.0 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
           A   + I     EE  E A         EL +E  DL+    ++  +  +    D +TV+
Sbjct: 64  AQTFQTIVPFTLEEAYEVADTIERLALDELPDELGDLLFQVVFYCQLGKEQGRFDFSTVV 123

Query: 196 ----ENLRKRH 202
               + L +RH
Sbjct: 124 NKITDKLTRRH 134


>UniRef50_D1R6W2 Putative uncharacterized protein n=1 Tax=Parachlamydia
           acanthamoebae str. Hall's coccus RepID=D1R6W2_9CHLA
          Length = 252

 Score = 58.0 bits (139), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 12/71 (16%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTT-- 193
               + +   + EE  E   A    D   +  E  D    L +   +  ++    +    
Sbjct: 64  EQTLETLRSTLLEEAAEWIEAVDSGDVNHMEEELGDLFLNLFFITKLAEKEGKFRMAEPV 123

Query: 194 --VIENLRKRH 202
             +I  L +RH
Sbjct: 124 EHIIAKLIRRH 134


>UniRef50_A3YTK8 MazG n=1 Tax=Synechococcus sp. WH 5701 RepID=A3YTK8_9SYNE
          Length = 313

 Score = 56.8 bits (136), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 16/72 (22%), Positives = 23/72 (31%), Gaps = 8/72 (11%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRFELTNE----ASDLMYHLLVLLQDQGLDLTTV 194
                  +   V EE  E A A    D   L  E       ++ H  +  +    DLT +
Sbjct: 46  LEQTHASLVPYVLEEAHEVADAIRHGDDPHLAEELGDLLLQVLLHAQIASEAGRFDLTAI 105

Query: 195 IE----NLRKRH 202
                  L +RH
Sbjct: 106 SRGLHDKLVRRH 117



 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 14/59 (23%), Positives = 26/59 (44%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            + + +KV EE  E   A    D+     E  D+++ L+ + +  GLD    +    +R
Sbjct: 209 IEGVWEKVHEELDELKQAVASGDKVHAQEELGDVLFTLVNVARWCGLDPEAGLAGTNRR 267


>UniRef50_Q1D370 MazG family protein n=7 Tax=Proteobacteria RepID=Q1D370_MYXXD
          Length = 396

 Score = 56.8 bits (136), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 13/75 (17%), Positives = 21/75 (28%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALA----ATVHDRFELTNEASDLM----YHLLVLLQDQGLDL 191
               + +   + EE  E        A          E  DL+    +H  +  +     L
Sbjct: 33  EQDLRSLRPYLLEEAFEVLEEMDRVAYGGSWRTFCEELGDLLFQIVFHAQLASELGEFSL 92

Query: 192 TTVI----ENLRKRH 202
             V     + L  RH
Sbjct: 93  ADVAKAIGDKLVSRH 107



 Score = 54.1 bits (129), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 13/60 (21%), Positives = 24/60 (40%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
               +  K+ EE  E   A   +DR  + +E  D+++ L  L +  G      +    +R
Sbjct: 175 DVASVRAKLTEELGELDEAIAANDRDAIEHELGDVLFSLANLARFVGAPAEDALRMAIRR 234


>UniRef50_A4X3B3 MazG nucleotide pyrophosphohydrolase n=4 Tax=Actinomycetales
           RepID=A4X3B3_SALTO
          Length = 328

 Score = 56.8 bits (136), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 13/74 (17%), Positives = 27/74 (36%), Gaps = 11/74 (14%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLL---QDQGLDLT 192
           A   + +A  + EE  E   A +  D   L  E  D++     H  +     + +   + 
Sbjct: 136 AQTHRSLASFLVEECYEAYDAISAGDTDALREELGDVLLQVVLHARLAEELPEGERWSVD 195

Query: 193 TVI----ENLRKRH 202
            V     + + +R+
Sbjct: 196 DVAGGLVDKMVRRN 209


>UniRef50_C3WG55 Nucleoside triphosphate pyrophosphohydrolase n=3 Tax=Fusobacterium
           RepID=C3WG55_FUSMR
          Length = 254

 Score = 56.5 bits (135), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 25/71 (35%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
               + +   + EE  E   A    D  E   E  D++    +   +  ++   ++  V 
Sbjct: 25  EQTLESLKPCLREEVAELLEAME-GDIEEHKGELGDVLMNLVFQADIREKEGKFNIEDVA 83

Query: 196 ----ENLRKRH 202
               E L +RH
Sbjct: 84  YEINEKLIRRH 94



 Score = 40.3 bits (93), Expect = 0.042,   Method: Composition-based stats.
 Identities = 12/67 (17%), Positives = 31/67 (46%), Gaps = 4/67 (5%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD----LTTVIE 196
              +++  K+ EE  E  +     D+ ++ +E  D+++ ++ + +   +D    L   I+
Sbjct: 159 DNVEQVFDKIYEELDELKVEIERKDKEKMKDELGDVLFSIVNIARFLDIDATEALEGTIK 218

Query: 197 NLRKRHQ 203
              KR +
Sbjct: 219 KFDKRFR 225


>UniRef50_B3DSB2 Tetrapyrrole methyltransferase-like protein n=8 Tax=Bifidobacterium
           RepID=B3DSB2_BIFLD
          Length = 299

 Score = 56.1 bits (134), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 16/73 (21%), Positives = 25/73 (34%), Gaps = 10/73 (13%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTT 193
               K + + + EE  E   A   HDR  +  E  D++    +   V   D      +  
Sbjct: 58  KQTNKSLLKNLLEETYEYVDAVETHDRDNMREELGDVLLQSVFQARVCESDTEDPFGIDE 117

Query: 194 VIE----NLRKRH 202
           V +     L  RH
Sbjct: 118 VADRLVNKLITRH 130


>UniRef50_C8X332 Type III restriction protein res subunit n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X332_DESRD
          Length = 979

 Score = 55.7 bits (133), Expect = 9e-07,   Method: Composition-based stats.
 Identities = 15/105 (14%), Positives = 39/105 (37%), Gaps = 7/105 (6%)

Query: 99  KGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETA 158
            G+   +     +     ++  ++ +        S + +          QK+ EE  E  
Sbjct: 5   SGSHPIYYHKLVR----DKIPSIIRDNDHQPTVLSLSGQDLTQAAS---QKLLEEAYELF 57

Query: 159 LAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
               V ++  +  E++D++  +L +L+  G     +I  +  R +
Sbjct: 58  TEVQVGEKPSVLKESADVLEVVLTILKQLGYSFDDLISEMELRRE 102


>UniRef50_UPI0001C317DB MazG family protein n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C317DB
          Length = 275

 Score = 55.7 bits (133), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 20/71 (28%), Positives = 29/71 (40%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYH----LLVLLQDQGLDLTTVI 195
               + I     EE  E A AA   D  +L +E  D+++      L+L +    DL  V 
Sbjct: 31  EQDERTIVPHTLEEAYELADAANRRDDVKLLDELGDVLFQVHFLALLLEERGAGDLAAVA 90

Query: 196 E----NLRKRH 202
           E     L +RH
Sbjct: 91  ENTRQKLIRRH 101


>UniRef50_D1SEV4 MazG family protein n=1 Tax=Micromonospora aurantiaca ATCC 27029
           RepID=D1SEV4_9ACTO
          Length = 329

 Score = 55.3 bits (132), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 13/74 (17%), Positives = 27/74 (36%), Gaps = 11/74 (14%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLL---QDQGLDLT 192
           A   + +A  + EE  E   A +  D   L  E  D    ++ H  +     + +   + 
Sbjct: 136 AQTHRSLAGFLLEECYEAYDAISADDTDALREELGDVLLQVLLHARLAENLPEGKSWTVD 195

Query: 193 TVI----ENLRKRH 202
            V     + + +R+
Sbjct: 196 DVAGTLVDKMVRRN 209


>UniRef50_C2CLU6 Nucleoside triphosphate pyrophosphohydrolase n=8
           Tax=Corynebacterium RepID=C2CLU6_CORST
          Length = 220

 Score = 55.3 bits (132), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 16/71 (22%), Positives = 24/71 (33%), Gaps = 9/71 (12%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVH-DRFELTNEASD----LMYHLLVLLQDQGLDLTTV 194
           A   + +   + EE  E A A        EL  E  D    +++H  +  +     L  V
Sbjct: 106 AQTHESLLPYLAEESQEFAEAVRERAGDEELCKELGDVLLQVLFHAELASRRGAFTLDDV 165

Query: 195 I----ENLRKR 201
                  LR R
Sbjct: 166 AVSFVTKLRSR 176


>UniRef50_B0UHR4 Phosphoribosyl-ATP pyrophosphatase n=10 Tax=Alphaproteobacteria
           RepID=HIS2_METS4
          Length = 107

 Score = 55.3 bits (132), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 40/92 (43%), Positives = 59/92 (64%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L  L++++  R +A P+ SYTAKL A+G  + A+K+GEE VE A+AA   DR  L
Sbjct: 1   MTAFSLADLDRIVRSRAAASPDQSYTAKLVAAGPAKPAKKLGEEAVEAAIAAVQGDRAGL 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKR 201
            +EA+D++YHLLV+L   G+ L  V+  L +R
Sbjct: 61  VSEAADVLYHLLVVLVGSGVALEDVMAELERR 92


>UniRef50_B2S417 Protein MazG n=2 Tax=Treponema pallidum RepID=B2S417_TREPS
          Length = 303

 Score = 54.9 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 15/81 (18%), Positives = 24/81 (29%), Gaps = 14/81 (17%)

Query: 136 AKLYASGTKRIAQKVGEEGVETALAATVH------DRFELTNEASDLMYH-LLVL---LQ 185
           A   A     +     EE  E   A              +  E  D++ +  ++     Q
Sbjct: 26  AWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHSSYAHVQEELGDVLMNVCMIAYMYEQ 85

Query: 186 DQGLDLTTVI----ENLRKRH 202
                L  V+    E L +RH
Sbjct: 86  RGVFSLADVVTALTEKLIRRH 106


>UniRef50_Q0F3U2 Nucleoside triphosphate pyrophosphohydrolase n=1 Tax=Mariprofundus
           ferrooxydans PV-1 RepID=Q0F3U2_9PROT
          Length = 252

 Score = 54.9 bits (131), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 13/75 (17%), Positives = 25/75 (33%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFE----LTNEASDLM----YHLLVLLQDQGLDL 191
                 + +   EE  E   A    D+      L +E  DL+    ++  +  +    + 
Sbjct: 13  EQTLLSLRRYTLEEVHEVIEAIDAADQSNDWLPLKDELGDLLLQVVFYAQIAEEADAFNF 72

Query: 192 TTVIE----NLRKRH 202
             VI+     +  RH
Sbjct: 73  GDVIDALINKMIYRH 87


>UniRef50_C6LFH2 MazG protein n=1 Tax=Bryantella formatexigens DSM 14469
           RepID=C6LFH2_9FIRM
          Length = 167

 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 14/75 (18%), Positives = 28/75 (37%), Gaps = 12/75 (16%)

Query: 140 ASGTKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLMYHL----LVLLQDQGLDL 191
           A   + +   +  E VE   A        D   L  E  D++  +     +  ++   D+
Sbjct: 38  AQTHESLKPCMINETVEALAAIDVWRETGDDSNLCEELGDMLLQVVLQSQIAAEEGLFDI 97

Query: 192 TTVI----ENLRKRH 202
           + V+    E + +RH
Sbjct: 98  SDVLQAACEKMIRRH 112


>UniRef50_A6TJN3 MazG family protein n=33 Tax=Bacteria RepID=A6TJN3_ALKMQ
          Length = 486

 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 23/71 (32%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDR----FELTNEASDLMYHLLVLLQDQGLDLTTVI 195
               + +   + EE  E        D      EL +    +++H  V  +     +  VI
Sbjct: 254 EQTHESLKPYLIEEAYEVLETIDEKDDFGLEEELGDLLLQVVFHAQVAHERGAFRIQDVI 313

Query: 196 E----NLRKRH 202
           E     L  RH
Sbjct: 314 EGICQKLVFRH 324



 Score = 41.1 bits (95), Expect = 0.021,   Method: Composition-based stats.
 Identities = 11/50 (22%), Positives = 23/50 (46%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
           +KV EE  E   A    +   +  E+ DL++ ++ +L+   +D    +  
Sbjct: 395 EKVHEELQELLEAKAEGEVEHIQEESGDLLFAVVNVLRFFKVDPEVALNK 444


>UniRef50_Q8DTR6 Putative phosphoribosyl-ATP pyrophosphohydrolase n=1
           Tax=Streptococcus mutans RepID=Q8DTR6_STRMU
          Length = 61

 Score = 54.5 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 15/46 (32%), Positives = 25/46 (54%)

Query: 157 TALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRH 202
             + A   D+ E+ +E +DL+YHL V+L + G+    V   L+ R 
Sbjct: 1   MVIGAKNADKIEIASETADLLYHLAVMLVETGVTPADVEAVLKSRQ 46


>UniRef50_UPI00003932E2 COG0139: Phosphoribosyl-AMP cyclohydrolase n=1 Tax=Bifidobacterium
           longum DJO10A RepID=UPI00003932E2
          Length = 68

 Score = 53.8 bits (128), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 15/33 (45%), Positives = 19/33 (57%)

Query: 73  NVVSIAPDCDNDTLLVLANPIGPTCHKGTSSCF 105
            V  ++ DCD D LLV  + +G  CH G  SCF
Sbjct: 19  YVKGVSLDCDGDALLVEVDQVGAACHTGKRSCF 51


>UniRef50_Q0FF05 MazG family protein n=3 Tax=Rhodobacterales RepID=Q0FF05_9RHOB
          Length = 277

 Score = 52.6 bits (125), Expect = 8e-06,   Method: Composition-based stats.
 Identities = 16/113 (14%), Positives = 36/113 (31%), Gaps = 15/113 (13%)

Query: 98  HKGTSSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVET 157
           ++    C          L  +++L   +     +            + IA    EE  E 
Sbjct: 6   NESQRICVSSNGEISRLLEIMKRLRDPKDGCPWD-------IEQTYETIAPYTIEEAYEV 58

Query: 158 ALAATVHDRF----ELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRKRH 202
           + A    +      EL +    ++Y   +  +D      +V+    + + +RH
Sbjct: 59  SDAIDQGNWHELEGELGDLLLQVIYFTQIGSEDGHFSFESVVKNVSDKMIRRH 111


>UniRef50_UPI0001699CB9 phosphoribosyl-AMP cyclohydrolase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699CB9
          Length = 128

 Score = 52.2 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 11/35 (31%), Positives = 22/35 (62%), Gaps = 1/35 (2%)

Query: 5  QQRRELDWEKTDGLMPVIVQHAVSGEVLMLGYMNP 39
          +   ++ W+  +GL+P I Q   +G++LM+ +MN 
Sbjct: 3  EWINQIKWD-DNGLVPAIAQETGTGKILMMAWMNQ 36


>UniRef50_D2QL02 MazG family protein n=76 Tax=Bacteria RepID=D2QL02_9SPHI
          Length = 279

 Score = 51.8 bits (123), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 15/76 (19%), Positives = 27/76 (35%), Gaps = 13/76 (17%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQD-----QGLD 190
               + +     EE  E + A   +D  E+  E  D    L+++  +  +         D
Sbjct: 36  KQTLESLRHLTIEETYELSDAILENDLPEIRKEIGDIQLHLVFYAKIASEAPADSPDRFD 95

Query: 191 LTTVI----ENLRKRH 202
           +  V+    E L  RH
Sbjct: 96  IADVLNSVCEKLISRH 111


>UniRef50_D1NV29 Transcriptional regulator, MazG family n=3 Tax=Bifidobacterium
           RepID=D1NV29_9BIFI
          Length = 198

 Score = 51.8 bits (123), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 14/67 (20%), Positives = 25/67 (37%), Gaps = 10/67 (14%)

Query: 146 IAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQG--LDLTTV----I 195
           + + + EE  E   A    DR  +  E  D++    +   +  +D      L  V    +
Sbjct: 1   MIKPLLEETYEYIDAVETDDRDNMREELGDMLLQSIFQAQICSEDSADPFTLDEVCDRLV 60

Query: 196 ENLRKRH 202
           + L  RH
Sbjct: 61  DKLITRH 67


>UniRef50_B7AVE3 Putative uncharacterized protein n=1 Tax=Bacteroides pectinophilus
           ATCC 43243 RepID=B7AVE3_9BACE
          Length = 165

 Score = 51.8 bits (123), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 14/71 (19%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNE----ASDLMYHLLVLLQDQGLDLTTVI 195
               + I   + +E  E   A    D   L  E       ++ H  +  ++    L  VI
Sbjct: 33  EQTHESITGCLRDESEEVIEAIENRDYLNLREELGDLLLQVLLHARIAEENGEFTLEDVI 92

Query: 196 EN----LRKRH 202
           +     L +RH
Sbjct: 93  DELGHKLVRRH 103


>UniRef50_C8PQ63 MazG family protein n=1 Tax=Treponema vincentii ATCC 35580
           RepID=C8PQ63_9SPIO
          Length = 312

 Score = 51.8 bits (123), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 13/77 (16%), Positives = 26/77 (33%), Gaps = 13/77 (16%)

Query: 139 YASGTKRIAQKVGEEGVETALAATVHDRF-----ELTNEASDLMYHLLVLL----QDQGL 189
                  +   + EE  ET  A                E  D++ +++++     Q+Q  
Sbjct: 54  IEQTPMTLRATLLEETYETIEALEEASSNSAEAVHAAEELGDVLLNIVMIAYMFEQEQAF 113

Query: 190 DLTTVIE----NLRKRH 202
            +  +I      L +RH
Sbjct: 114 SVAEMIRSLNEKLIRRH 130



 Score = 40.7 bits (94), Expect = 0.032,   Method: Composition-based stats.
 Identities = 12/67 (17%), Positives = 21/67 (31%), Gaps = 4/67 (5%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----E 196
                  +K  EE  E   A       E   E  DL++ L+   +   +D    +     
Sbjct: 203 DNADGPQKKTEEELAEFTEALAHGTHEEAEAEFGDLLFSLVNTARHLHIDPAIALSRTNA 262

Query: 197 NLRKRHQ 203
              +R +
Sbjct: 263 KFERRFR 269


>UniRef50_D1CG10 MazG family protein n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CG10_THET1
          Length = 503

 Score = 51.5 bits (122), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 22/71 (30%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFE----LTNEASDLMYHLLVLLQDQGLDLTTVI 195
                 I + + EE  E   A    D       L +    +  H  +   +   ++  VI
Sbjct: 266 EQNHYSIKRYLLEEAYEVIDALDKQDIDALEEELGDLLLQISLHSEIAYSESEFEIGDVI 325

Query: 196 E----NLRKRH 202
                 L +RH
Sbjct: 326 RFLTSKLIRRH 336


>UniRef50_A4IJD4 Tetrapyrrole methylase family protein, MazG family protein n=15
           Tax=Bacteria RepID=A4IJD4_GEOTN
          Length = 486

 Score = 50.7 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 13/71 (18%), Positives = 24/71 (33%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLM----YHLLVLLQDQGLDLTTVI 195
                 + + + EE  E   A   +D   +  E  D++     H  +   D    +  VI
Sbjct: 253 KQTHASLKRYLLEEAYELLEAIDENDDDHMVEELGDVLLQVMLHAQIGADDGLFSIDDVI 312

Query: 196 E----NLRKRH 202
                 + +RH
Sbjct: 313 RTLTAKMIRRH 323



 Score = 40.7 bits (94), Expect = 0.030,   Method: Composition-based stats.
 Identities = 17/65 (26%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----E 196
           +  + I QKV EE  E     +   R EL +E  D+M+ L+ L +  G+     +    +
Sbjct: 387 NDVEPIWQKVEEEMAEFRAETSSGRRAELVSEFGDVMFALINLARYYGIQPEEALQRAND 446

Query: 197 NLRKR 201
              +R
Sbjct: 447 KFTRR 451


>UniRef50_UPI000185C266 nucleoside triphosphate pyrophosphohydrolase n=1
           Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C266
          Length = 343

 Score = 50.7 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 14/70 (20%), Positives = 23/70 (32%), Gaps = 13/70 (18%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL----MYHLLVLLQDQGLDLTTVIE 196
              K +   + EE  E   A       ++ +E SDL    ++H  +       D   V  
Sbjct: 152 QTHKSLLPYLIEETYEFVDAVNEGG--DIRSELSDLLLQVLFHAEIAE---DFDFDDVAT 206

Query: 197 ----NLRKRH 202
                +R R 
Sbjct: 207 DFILKMRARQ 216


>UniRef50_C0AY94 Putative uncharacterized protein n=1 Tax=Proteus penneri ATCC 35198
           RepID=C0AY94_9ENTR
          Length = 122

 Score = 50.7 bits (120), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 13/41 (31%), Positives = 17/41 (41%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL 181
                IA    EE  E   A T  D  +L  E  DL+Y ++
Sbjct: 58  QTFDTIAPYTLEETYEVLDAITRKDFADLKEELGDLLYQVV 98


>UniRef50_C8NTB1 MazG family transcriptional regulator n=3 Tax=Corynebacterium
           RepID=C8NTB1_9CORY
          Length = 210

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 13/92 (14%), Positives = 30/92 (32%), Gaps = 9/92 (9%)

Query: 119 EQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAAT-VHDRFELTNEASDLM 177
           + +   ++      +          + + + + +E  E A A        E+  E SDL+
Sbjct: 83  DPVYQAQRVMRAARTRGEWEMGQTHESLLEYLEQESAEFADAVRTEQGDEEMKKELSDLL 142

Query: 178 ----YHLLVLLQDQGLDLTTVI----ENLRKR 201
               +H  +  Q        V     + ++ R
Sbjct: 143 LQVLFHAEIANQRGAFSFADVAQAFVDKMKSR 174


>UniRef50_C9KKM0 Tetrapyrrole methylase family protein/MazG family protein n=2
           Tax=Veillonellaceae RepID=C9KKM0_9FIRM
          Length = 163

 Score = 50.3 bits (119), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 11/74 (14%), Positives = 20/74 (27%), Gaps = 12/74 (16%)

Query: 141 SGTKRIAQKVGEEGVETALAA----TVHDRFELTNEASDLM----YHLLVLLQDQGLDL- 191
              + +     EE  E                L  E  DL+    +H  +  ++    L 
Sbjct: 33  QTHESLKPACIEEAAEVLGGIDILRETGRAENLKEELGDLLLQVVFHAQLAQEEGLFSLA 92

Query: 192 ---TTVIENLRKRH 202
                    + +RH
Sbjct: 93  DVAEAAAAKMVRRH 106


>UniRef50_UPI0000510014 MazG family protein n=1 Tax=Brevibacterium linens BL2
           RepID=UPI0000510014
          Length = 160

 Score = 49.9 bits (118), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 15/82 (18%), Positives = 26/82 (31%), Gaps = 19/82 (23%)

Query: 140 ASGTKRIAQKVGEEGVETALAATV-------HDRFELTNEASD----LMYHLLVLLQDQ- 187
                 + +   EE  E   A            R  +  E  D    +++H  +L +   
Sbjct: 41  KQDHGSLEKYAREETEELIEALEDYRSDASPAHRAAVVEELGDVFYQVLFHSALLDESGS 100

Query: 188 -------GLDLTTVIENLRKRH 202
                  GL +  + E L +RH
Sbjct: 101 APYGHTLGLIIDGLEEKLIRRH 122


>UniRef50_A5USY4 MazG family protein n=2 Tax=Roseiflexus RepID=A5USY4_ROSS1
          Length = 515

 Score = 49.5 bits (117), Expect = 7e-05,   Method: Composition-based stats.
 Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLL----VLLQDQGLDLTT-- 193
               + +   + EE  E   A    D   L  E  DL+ ++L    +  Q    D     
Sbjct: 278 EQTPQSLRPALLEEVHEVLEALDADDDAALVEELGDLLINILMQSEMARQAGRFDAGDVF 337

Query: 194 --VIENLRKRH 202
             V E L +RH
Sbjct: 338 STVAEKLIRRH 348


>UniRef50_Q2J4X9 Phosphoribosyl-ATP pyrophosphatase n=1 Tax=Frankia sp. CcI3
           RepID=Q2J4X9_FRASC
          Length = 116

 Score = 48.4 bits (114), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 24/94 (25%), Positives = 34/94 (36%)

Query: 105 FGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVH 164
                       +L   LAE+       S T      G   + +K+ EE  E  +AA   
Sbjct: 23  DSSNVSNLKTFDELFVELAEKWRRRTPGSGTVAALDQGVHHLGKKLVEEAAEAWMAAEHE 82

Query: 165 DRFELTNEASDLMYHLLVLLQDQGLDLTTVIENL 198
            R     E S L+Y   +L+   GL L  V  +L
Sbjct: 83  GRGRAAEEISQLLYWSQLLMISLGLSLDDVYSHL 116


>UniRef50_C7MC77 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Brachybacterium faecium DSM 4810
           RepID=C7MC77_BRAFD
          Length = 262

 Score = 47.6 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 17/94 (18%), Positives = 33/94 (35%), Gaps = 15/94 (15%)

Query: 121 LLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATV---HDRFELTNEASDL- 176
            + E   A    ++T   +      +A+ + EE  E          H    L +E  DL 
Sbjct: 26  EVMEALRAPDGDAWT---HQQSHASLARYLLEETHEVLEVIDDPAVHGAGALADELGDLL 82

Query: 177 ---MYHLLVLLQDQ-GLDLTTVIE----NLRKRH 202
              ++H  V  ++    D+  V       + +R+
Sbjct: 83  FQILFHARVGQEEDPAWDIDDVARAFITKMERRN 116


>UniRef50_Q8TY54 Predicted pyrophosphatase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TY54_METKA
          Length = 103

 Score = 47.6 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 13/49 (26%), Positives = 22/49 (44%)

Query: 148 QKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE 196
            ++ EE +E   A    +R  L  E  DL+  +   L    +DL  ++E
Sbjct: 41  ARLVEEAIEVRNAVRSGNREALIEELGDLLIEVEAFLTAHDIDLEEIVE 89


>UniRef50_B1L6A5 MazG nucleotide pyrophosphohydrolase n=2 Tax=Archaea
           RepID=B1L6A5_KORCO
          Length = 96

 Score = 46.4 bits (109), Expect = 6e-04,   Method: Composition-based stats.
 Identities = 15/78 (19%), Positives = 27/78 (34%), Gaps = 3/78 (3%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           +         Y  +    G    A  +GEE  E   A   +    + +E +D+   LL +
Sbjct: 4   KEAQGLIREIYGERDSKRGILGTALHLGEEVGELFRAIRSNQSDNMKDELADVFAWLLSV 63

Query: 184 LQDQGLDLTTVIENLRKR 201
            +   +DL        +R
Sbjct: 64  SELLSIDLEDA---FVRR 78


>UniRef50_D2RFM2 MazG nucleotide pyrophosphohydrolase n=3 Tax=Euryarchaeota
           RepID=D2RFM2_ARCPR
          Length = 96

 Score = 45.7 bits (107), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 14/64 (21%), Positives = 27/64 (42%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193
           Y  +    G ++    + EE  E A A   +D   +  E +D+   L+ L     +DL +
Sbjct: 14  YYERDLKRGKEKTMLWLVEEIGELAEAVRKNDLNSIREEMADVFAWLVSLANLYDVDLES 73

Query: 194 VIEN 197
            ++ 
Sbjct: 74  AVKE 77


>UniRef50_A3EPX0 MazG family protein (Nucleotide pyrophosphohydrolase domain) n=2
           Tax=Leptospirillum sp. Group II RepID=A3EPX0_9BACT
          Length = 301

 Score = 45.7 bits (107), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 11/71 (15%), Positives = 28/71 (39%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASD----LMYHLLVLLQDQGLDLTTVI 195
                R+   + EE  E   A        + +E  D    L++   +L +++ + +  ++
Sbjct: 57  EQTVPRLLNDLREELHELQEAVEDKKHMAILSEIGDMVLILLFIRRILWEEKPISVAELL 116

Query: 196 E----NLRKRH 202
           +     + +RH
Sbjct: 117 DHTSGKMVRRH 127


>UniRef50_C7RKB9 MazG nucleotide pyrophosphohydrolase n=1 Tax=Candidatus
           Accumulibacter phosphatis clade IIA str. UW-1
           RepID=C7RKB9_9PROT
          Length = 97

 Score = 45.3 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 18/68 (26%), Positives = 28/68 (41%), Gaps = 1/68 (1%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTT 193
           Y+    A G ++      EE  E A A +  +   +  E  D++  L+ L    G DL  
Sbjct: 22  YSTVDQARGPEKTFLFFVEEVGELATALSRRNAENIEEEIGDVLMWLVSLANLTGTDLRD 81

Query: 194 -VIENLRK 200
            V   LR+
Sbjct: 82  CVAAYLRR 89


>UniRef50_C5C986 Protein with tetrapyrrole methyltransferase and pyrophosphatase
           domains n=1 Tax=Micrococcus luteus NCTC 2665
           RepID=C5C986_MICLC
          Length = 269

 Score = 44.9 bits (105), Expect = 0.001,   Method: Composition-based stats.
 Identities = 16/98 (16%), Positives = 27/98 (27%), Gaps = 32/98 (32%)

Query: 134 YTAKLYASGTKRIAQKVGEEGVETALAATVHDRF---------------ELTNEASDLMY 178
           +TA L       +A+ + EE  E        D                  L  E  D+++
Sbjct: 21  WTAAL---THADLAEYLVEEAYEAVAEIESRDAAAWADVPARRADGAYPALAAELGDVLF 77

Query: 179 ----HLLVL------LQDQGLDLTTVI----ENLRKRH 202
               H  V        +  G  L          + +R+
Sbjct: 78  QVVLHAAVSRAPGAPAETAGFRLDDAADALTAKMIRRN 115


>UniRef50_B5GY79 Secreted protein n=6 Tax=Streptomyces RepID=B5GY79_STRCL
          Length = 180

 Score = 44.9 bits (105), Expect = 0.002,   Method: Composition-based stats.
 Identities = 12/51 (23%), Positives = 21/51 (41%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
           + EE  E +  A       L  E +D++Y         G+DL  V+  + +
Sbjct: 85  LAEEFAEVSEVAVTGPLDHLAQELADVVYIAYGTALVHGIDLDEVLAEVHR 135


>UniRef50_A1RTU9 Phosphoribosyl-ATP pyrophosphatase n=6 Tax=Thermoproteaceae
           RepID=HIS2_PYRIL
          Length = 94

 Score = 44.5 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 39/94 (41%), Positives = 54/94 (57%)

Query: 110 HQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFEL 169
                L +LE+++  R       SYT +LY+SG   +A+KVGEE VE A+AA    +  +
Sbjct: 1   MSCEILRKLEEVIRRRIEEKNPESYTYRLYSSGIHNVARKVGEEAVEVAVAALAEGKSRI 60

Query: 170 TNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
             EA+DL+YHLLVLL   GL L  V   L +R +
Sbjct: 61  VEEAADLLYHLLVLLNSTGLSLGDVCAELERRMR 94


>UniRef50_C4LHL5 Putative uncharacterized protein n=1 Tax=Corynebacterium
           kroppenstedtii DSM 44385 RepID=C4LHL5_CORK4
          Length = 370

 Score = 44.1 bits (103), Expect = 0.003,   Method: Composition-based stats.
 Identities = 11/74 (14%), Positives = 26/74 (35%), Gaps = 10/74 (13%)

Query: 140 ASGTKRIAQKVGEEGVET------ALAATVHDRFELTNEASD----LMYHLLVLLQDQGL 189
           +   + +   + EE  E         A  +     L +E SD    +++H  +  +    
Sbjct: 246 SQSHQSLLAYLREEVEELAQSIDTWQAGDLASEKRLCDELSDIFLQVLFHAEIANRRGAF 305

Query: 190 DLTTVIENLRKRHQ 203
           D+  V  +   + +
Sbjct: 306 DIGHVAASFVHKMR 319


>UniRef50_A8ATT3 Gp45 n=1 Tax=Listeria phage P35 RepID=A8ATT3_9CAUD
          Length = 104

 Score = 43.7 bits (102), Expect = 0.004,   Method: Composition-based stats.
 Identities = 16/62 (25%), Positives = 24/62 (38%)

Query: 131 ETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLD 190
           + S    L     +    KV EE  ET  A    D+  L  E  D+   +++L Q   L 
Sbjct: 14  QWSRNKGLDTKDPRNQMLKVVEEVGETTQALVKGDKDHLPEEIGDIFVTIVILAQQLSLT 73

Query: 191 LT 192
           + 
Sbjct: 74  IE 75


>UniRef50_B7JWE8 MazG nucleotide pyrophosphohydrolase n=2 Tax=Cyanothece
           RepID=B7JWE8_CYAP8
          Length = 110

 Score = 43.0 bits (100), Expect = 0.006,   Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 24/60 (40%), Gaps = 4/60 (6%)

Query: 144 KRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRKRHQ 203
           + +  K+ EE  E   A    D   L  E  DL   +  +L    +   TVI   ++R +
Sbjct: 36  EALKHKLLEEAQEVIEA----DPENLVKELGDLFEVIDNILIAYQISRETVINYQQQRRK 91


>UniRef50_A2BIS9 Mazg nucleotide pyrophosphohydrolase, chain A-conserved archaeal
           protein n=13 Tax=Thermoprotei RepID=A2BIS9_HYPBU
          Length = 100

 Score = 42.6 bits (99), Expect = 0.008,   Method: Composition-based stats.
 Identities = 11/48 (22%), Positives = 18/48 (37%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
             EE  E A A    D+  +  E  D++   L +    G+D     + 
Sbjct: 31  FVEEVGELAEALLKGDKNLIAEEIGDVIAWALSIANLVGVDAEEAFKK 78


>UniRef50_B5Y801 MazG family protein n=1 Tax=Coprothermobacter proteolyticus DSM
           5265 RepID=B5Y801_COPPD
          Length = 352

 Score = 42.6 bits (99), Expect = 0.009,   Method: Composition-based stats.
 Identities = 11/65 (16%), Positives = 26/65 (40%), Gaps = 4/65 (6%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----E 196
               ++  K+ EE  E   A        + +E  DL++ ++ L +   +D    +    +
Sbjct: 263 EDPMQLKDKLEEEFEELRCAFESGQTQSMKDEVGDLLFTVVNLARLLNVDPEDALLHSSK 322

Query: 197 NLRKR 201
             ++R
Sbjct: 323 KFQRR 327


>UniRef50_C5ZZZ8 Beta-lactamase regulatory-like protein, mazg protein n=6
           Tax=cellular organisms RepID=C5ZZZ8_THESM
          Length = 96

 Score = 42.2 bits (98), Expect = 0.010,   Method: Composition-based stats.
 Identities = 15/71 (21%), Positives = 28/71 (39%)

Query: 127 SADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQD 186
               +  Y  +    G ++      EE  E A A   +DR  +  E +D++  L+ L   
Sbjct: 7   QELIKELYFHRDEKRGLEKTFLWFSEEIGELAEALRKNDREAMDEEFADVLAWLVSLANI 66

Query: 187 QGLDLTTVIEN 197
            G+D+    + 
Sbjct: 67  VGVDVEEAAKK 77


>UniRef50_Q12UY5 Protein with MazG nucleotide pyrophosphohydrolase domain n=6
           Tax=Euryarchaeota RepID=Q12UY5_METBU
          Length = 95

 Score = 41.8 bits (97), Expect = 0.012,   Method: Composition-based stats.
 Identities = 12/43 (27%), Positives = 17/43 (39%)

Query: 150 VGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           + EE  E A A   +D   L  E +D    +  L     +DL 
Sbjct: 30  LVEEVGELAEAIRRNDMENLREELADCFAWIGALANLYDIDLE 72


>UniRef50_Q3JCR4 Tetrapyrrole methylase family protein / MazG family protein n=2
           Tax=Nitrosococcus oceani RepID=Q3JCR4_NITOC
          Length = 180

 Score = 41.8 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 14/63 (22%), Positives = 26/63 (41%), Gaps = 5/63 (7%)

Query: 146 IAQKVGEEGVETALAAT-VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVI----ENLRK 200
           I +K+ EE  E   A T   +   L  E  DL++  + L +  G+     +    +   +
Sbjct: 82  ILEKIEEELQEVRAALTSNENSSRLQEEIGDLLFACINLARHTGIMPEAALDSCSDKFER 141

Query: 201 RHQ 203
           R +
Sbjct: 142 RFR 144


>UniRef50_D2RFM8 MazG nucleotide pyrophosphohydrolase n=1 Tax=Archaeoglobus
           profundus DSM 5631 RepID=D2RFM8_ARCPR
          Length = 92

 Score = 41.8 bits (97), Expect = 0.014,   Method: Composition-based stats.
 Identities = 13/52 (25%), Positives = 23/52 (44%)

Query: 141 SGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
           SG   +   + EE  E A A    D   +  E +D+++ +L L     +D+ 
Sbjct: 21  SGELFLLAVLFEEVGELAEAVRKRDVKAIEEELTDVLFMVLSLANYFNVDIE 72


>UniRef50_D2QAY9 MazG nucleotide pyrophosphohydrolase n=15 Tax=cellular organisms
           RepID=D2QAY9_9BIFI
          Length = 107

 Score = 41.4 bits (96), Expect = 0.017,   Method: Composition-based stats.
 Identities = 14/67 (20%), Positives = 25/67 (37%), Gaps = 7/67 (10%)

Query: 141 SGTKRIAQKVGEEGVETALAA------TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTV 194
                +A+ V  E  E              D   +  E +D++ + ++L    G DL  +
Sbjct: 23  HTPGNLAKSVSIEAAELLECFQWSDEPRNDDLEHVHEEIADVLIYSIMLSNKLGFDLDEI 82

Query: 195 I-ENLRK 200
           I + L K
Sbjct: 83  ILDKLSK 89


>UniRef50_C8S8Z5 MazG nucleotide pyrophosphohydrolase n=2 Tax=Archaeoglobaceae
           RepID=C8S8Z5_FERPL
          Length = 91

 Score = 41.4 bits (96), Expect = 0.020,   Method: Composition-based stats.
 Identities = 12/53 (22%), Positives = 22/53 (41%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLT 192
            SG   +   + EE  E A      D  ++  E  D+++ +L L    G++  
Sbjct: 20  KSGELFLLAVLFEEVGELAEVVRKRDVEKIEEELCDVLFMILSLANYFGVNPE 72


>UniRef50_C2BZZ6 MazG nucleotide pyrophosphohydrolase n=2 Tax=Listeria
           RepID=C2BZZ6_LISGR
          Length = 107

 Score = 41.1 bits (95), Expect = 0.022,   Method: Composition-based stats.
 Identities = 16/80 (20%), Positives = 32/80 (40%), Gaps = 11/80 (13%)

Query: 133 SYTAKLYASGTKRIAQKVGEEGVETALAATV-------HDRFELTNEASDLMYHLLVLLQ 185
           S TA+++          +  E  E A             D+  LT E  D+++++  + +
Sbjct: 13  SRTAQIHEQALTNYGLGISGEAGEVAELIKKYAFHGHTLDKANLTKELGDVLWYISQIAK 72

Query: 186 DQGLDLTTV----IENLRKR 201
              + +  V    IE L++R
Sbjct: 73  WADIPMEQVASENIEKLKRR 92


>UniRef50_B7GRX0 MazG nucleotide pyrophosphohydrolase n=7 Tax=cellular organisms
           RepID=B7GRX0_BIFLI
          Length = 129

 Score = 41.1 bits (95), Expect = 0.024,   Method: Composition-based stats.
 Identities = 11/67 (16%), Positives = 26/67 (38%), Gaps = 7/67 (10%)

Query: 141 SGTKRIAQKVGEEGVETALAAT------VHDRFELTNEASDLMYHLLVLLQDQGLDLTT- 193
              + +A+ +  E  E              D   +  E +D++ + +++    G+D+   
Sbjct: 26  HTPENLAKSISIEASELLECYQWTPQSPSMDEGHVREELADVLTYCIMMADALGVDMDDI 85

Query: 194 VIENLRK 200
           V+  L K
Sbjct: 86  VMGKLAK 92


>UniRef50_O32263 Uncharacterized protein yvdC n=97 Tax=Bacteria RepID=YVDC_BACSU
          Length = 106

 Score = 41.1 bits (95), Expect = 0.025,   Method: Composition-based stats.
 Identities = 17/75 (22%), Positives = 27/75 (36%), Gaps = 20/75 (26%)

Query: 149 KVGEEGVETALAATV----------------HDRFELTNEASDLMYHLLVLLQDQGLDLT 192
            + EE  E A A                     + EL  E  D++ ++ +L    G+ L 
Sbjct: 30  FLMEEAGELARAVRAYEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLE 89

Query: 193 TVI----ENLRKRHQ 203
            V+    E L KR +
Sbjct: 90  DVMKAHQEKLTKRFE 104


>UniRef50_B8G452 MazG nucleotide pyrophosphohydrolase n=4 Tax=Bacteria
           RepID=B8G452_CHLAD
          Length = 108

 Score = 41.1 bits (95), Expect = 0.026,   Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 23/60 (38%), Gaps = 11/60 (18%)

Query: 153 EGVETALAATVH-------DRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----NLRKR 201
           E  E A     H       DR  L  E  D++++  +        L+TV+      LR+R
Sbjct: 34  EAGEVADTVKKHLFHGHPLDREALMKELGDVLWYAALACDALDTSLSTVMAANIEKLRRR 93


>UniRef50_Q94MU3 P26 n=1 Tax=Myxococcus phage Mx8 RepID=Q94MU3_9CAUD
          Length = 124

 Score = 41.1 bits (95), Expect = 0.027,   Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 23/60 (38%), Gaps = 11/60 (18%)

Query: 153 EGVETALAAT-------VHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIE----NLRKR 201
           E  E A             D  ++  E  D+++++ V+     LDL  V       LRKR
Sbjct: 43  EAGEVADHVKKFVGHGHDLDVEKVKKELGDVLWYVAVIAARLDLDLGDVAAANVEKLRKR 102


>UniRef50_C7PX95 MazG nucleotide pyrophosphohydrolase n=1 Tax=Catenulispora
           acidiphila DSM 44928 RepID=C7PX95_CATAD
          Length = 158

 Score = 41.1 bits (95), Expect = 0.027,   Method: Composition-based stats.
 Identities = 14/99 (14%), Positives = 30/99 (30%), Gaps = 3/99 (3%)

Query: 102 SSCFGDTAHQWLFLYQLEQLLAERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAA 161
             C        +          +       ++  +   A     +   + EE  E A A 
Sbjct: 12  RLCVEPGLSDAMRAVAAFHTAFDLPRQPVPSTDVSTELAQLRVDL---LVEEVGEFADAT 68

Query: 162 TVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIENLRK 200
           +  D   + +   D++Y         G+DL  V+  + +
Sbjct: 69  SKRDLTAMADALGDIIYVAYGAAVTYGIDLDAVLMEIHR 107


>UniRef50_B9KBS0 MazG-related protein n=6 Tax=Thermotogaceae RepID=B9KBS0_THENN
          Length = 116

 Score = 40.7 bits (94), Expect = 0.028,   Method: Composition-based stats.
 Identities = 18/73 (24%), Positives = 25/73 (34%), Gaps = 8/73 (10%)

Query: 137 KLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHL----LVLLQDQGLDLT 192
            L       +   +  E  E   A    D   L  E  DL+Y       V  +D G+DL 
Sbjct: 18  WLERQSIDSLLDALASEVEEIRDAVKKKDLTNLEEEIGDLIYDAFLVGAVAQRDYGVDLE 77

Query: 193 ----TVIENLRKR 201
                V+E +  R
Sbjct: 78  RAIQRVVEKISHR 90


>UniRef50_C4Z5Y7 Putative uncharacterized protein n=1 Tax=Eubacterium eligens ATCC
           27750 RepID=C4Z5Y7_EUBE2
          Length = 176

 Score = 39.9 bits (92), Expect = 0.047,   Method: Composition-based stats.
 Identities = 15/60 (25%), Positives = 24/60 (40%), Gaps = 11/60 (18%)

Query: 153 EGVETALAAT-------VHDRFELTNEASDLMYHLLVLLQDQGLDLTTV----IENLRKR 201
           E  ET              DR  L  E  D+M+++ ++    G DL  +    I+ L+ R
Sbjct: 93  EAGETLDMIKKWIFHEKDLDREHLKKELGDVMWYMAMICYSFGFDLDEILQMNIDKLKAR 152


>UniRef50_A6VMS4 MazG nucleotide pyrophosphohydrolase n=26 Tax=Bacteria
           RepID=A6VMS4_ACTSZ
          Length = 110

 Score = 39.9 bits (92), Expect = 0.049,   Method: Composition-based stats.
 Identities = 20/81 (24%), Positives = 27/81 (33%), Gaps = 20/81 (24%)

Query: 139 YASGTKRIAQKVGEEGVETA----------------LAATVHDRFELTNEASDLMYHLLV 182
           Y          + EE  E A                 A+    R  L  E  D+M +L V
Sbjct: 20  YERNPFMRMTYLAEEMGEVACAVRAIEIGRERPDETEASQQQKRENLIEELGDVMDNLFV 79

Query: 183 LLQDQGLDLTTVIENLRKRHQ 203
           L    G+ +T V     +RHQ
Sbjct: 80  LADKYGISMTEV----IQRHQ 96


>UniRef50_A7GLU0 Phosphoribosyl-ATP pyrophosphohydrolase n=38 Tax=Bacillales
           RepID=A7GLU0_BACCN
          Length = 108

 Score = 39.9 bits (92), Expect = 0.051,   Method: Composition-based stats.
 Identities = 13/55 (23%), Positives = 23/55 (41%), Gaps = 3/55 (5%)

Query: 143 TKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
            + + +K  EE  E   A     +     E +DL+  +  L Q +G+ L  V + 
Sbjct: 34  IEEVCKKTQEELAEYVEA---ESKEHKVEELADLLELVNALAQHEGVTLEDVEKV 85


>UniRef50_C6HVH1 MazG family protein n=1 Tax=Leptospirillum ferrodiazotrophum
           RepID=C6HVH1_9BACT
          Length = 292

 Score = 39.9 bits (92), Expect = 0.051,   Method: Composition-based stats.
 Identities = 11/71 (15%), Positives = 26/71 (36%), Gaps = 8/71 (11%)

Query: 140 ASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDL---MYHL-LVLLQDQGLDLTTVI 195
               K +   + +E  E   +    D   L+ E  D+   ++    +L +   + L  ++
Sbjct: 54  KQTLKGLLSDLKDEVYELEESLEDGDLHNLSREMGDVFIILFMARRILWEQTTVSLGEIL 113

Query: 196 E----NLRKRH 202
           +     +  RH
Sbjct: 114 DGASLKMVSRH 124


>UniRef50_Q02X26 Predicted pyrophosphatase n=4 Tax=Lactococcus lactis
           RepID=Q02X26_LACLS
          Length = 115

 Score = 39.5 bits (91), Expect = 0.062,   Method: Composition-based stats.
 Identities = 15/64 (23%), Positives = 24/64 (37%), Gaps = 15/64 (23%)

Query: 153 EGVETALAATV-----------HDRFELTNEASDLMYHLLVLLQDQGLDLTTV----IEN 197
           E  E A                +D+  ++ E  DL+++L    +  G+ L  V    IE 
Sbjct: 39  EAGEVADKVKKVIRDQEGKLSVNDKKAISYELGDLLWYLATSARYLGISLEQVASENIEK 98

Query: 198 LRKR 201
           L  R
Sbjct: 99  LESR 102


>UniRef50_A8AB92 MazG nucleotide pyrophosphohydrolase n=6 Tax=Thermoprotei
           RepID=A8AB92_IGNH4
          Length = 89

 Score = 39.5 bits (91), Expect = 0.062,   Method: Composition-based stats.
 Identities = 20/82 (24%), Positives = 30/82 (36%), Gaps = 4/82 (4%)

Query: 124 ERKSADPETSYTAKLYASGTKRIAQKVGEEGVETALAATVHDRFELTNEASDLMYHLLVL 183
           E      E+ Y  K +  G +  A    EE  E A A        L  E +D++  LL L
Sbjct: 6   EELQKFVESEYFLKDFNRGVEATALWFVEEVGELAEAIIKG--EGLEEEFADVLAWLLSL 63

Query: 184 LQDQGLDLTTVIEN--LRKRHQ 203
                +DL    +   L +  +
Sbjct: 64  ANLLNVDLCEAFKKKYLERTRR 85


>UniRef50_C8XG56 MazG nucleotide pyrophosphohydrolase n=1 Tax=Nakamurella
           multipartita DSM 44233 RepID=C8XG56_NAKMY
          Length = 146

 Score = 39.5 bits (91), Expect = 0.067,   Method: Composition-based stats.
 Identities = 14/58 (24%), Positives = 24/58 (41%), Gaps = 1/58 (1%)

Query: 141 SGTKRIAQKVGEE-GVETALAATVHDRFELTNEASDLMYHLLVLLQDQGLDLTTVIEN 197
           S    + Q + EE   E A A    D   + +  +D++Y         G+DL  V++ 
Sbjct: 38  SDQALLRQALIEEEVGELADAVRAGDVVGVADALADIVYVAYGTAHVYGIDLDAVLDE 95


>UniRef50_Q4JU45 Putative uncharacterized protein n=2 Tax=Corynebacterium jeikeium
           RepID=Q4JU45_CORJK
          Length = 449

 Score = 39.5 bits (91), Expect = 0.077,   Method: Composition-based stats.
 Identities = 15/85 (17%), Positives = 25/85 (29%), Gaps = 25/85 (29%)

Query: 142 GTKRIAQKVGEEGVETALAAT-------VHDRF----------ELTNEASD----LMYHL 180
               + + + EE  E A             D            +L  E SD    +++H 
Sbjct: 176 THASLVKFLREETEELARTIDLMENWKPEGDGEGAARPEWIEQDLCAELSDVLLQVLFHA 235

Query: 181 LVLLQDQGLDLTTVI----ENLRKR 201
            +  +    D+  V       LR R
Sbjct: 236 EIANRRGAFDIGHVAGAFSAKLRAR 260


>UniRef50_C3PNV1 MazG-like protein n=4 Tax=spotted fever group RepID=C3PNV1_RICAE
          Length = 120

 Score = 39.1 bits (90), Expect = 0.086,   Method: Composition-based stats.
 Identities = 15/67 (22%), Positives = 28/67 (41%), Gaps = 5/67 (7%)

Query: 142 GTKRIAQKVGEEGVETALAATVHDR-FELTNEASDLMYHLLVLLQDQGLDLTTVI----E 196
             + I ++  +E  E   A    +    +  E  DL++  ++L    GLD+ T +    E
Sbjct: 16  DHEMILEQAIDECREIKEAIDDAEPPERIQAEIGDLLHTAILLCIFSGLDVETTLSKTNE 75

Query: 197 NLRKRHQ 203
              KR +
Sbjct: 76  KFEKRMR 82


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.314    0.149    0.467 

Lambda     K      H
   0.267   0.0457    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,529,963,323
Number of Sequences: 3077464
Number of extensions: 74253643
Number of successful extensions: 204086
Number of sequences better than 1.0e-01: 471
Number of HSP's better than  0.1 without gapping: 1054
Number of HSP's successfully gapped in prelim test: 213
Number of HSP's that attempted gapping in prelim test: 201777
Number of HSP's gapped (non-prelim): 1654
length of query: 203
length of database: 1,040,396,356
effective HSP length: 122
effective length of query: 81
effective length of database: 664,945,748
effective search space: 53860605588
effective search space used: 53860605588
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.3 bits)
S2: 90 (39.1 bits)
