BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for composition-based statistics: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (361 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 434 e-120 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 432 e-119 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 413 e-114 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 406 e-112 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 404 e-111 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 396 e-109 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 395 e-108 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 390 e-107 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 390 e-107 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 389 e-107 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 389 e-107 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 388 e-106 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 388 e-106 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 387 e-106 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 386 e-106 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 383 e-105 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 383 e-105 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 381 e-104 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 380 e-104 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 380 e-104 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 378 e-103 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 377 e-103 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 377 e-103 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 377 e-103 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 376 e-103 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 375 e-102 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 375 e-102 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 374 e-102 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 373 e-102 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 372 e-101 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 372 e-101 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 370 e-101 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 370 e-101 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 369 e-101 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 368 e-100 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 368 e-100 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 368 e-100 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 367 e-100 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 366 e-100 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 366 e-100 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 365 1e-99 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 365 2e-99 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 365 2e-99 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 364 2e-99 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 364 3e-99 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 364 3e-99 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 363 5e-99 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 363 5e-99 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 363 8e-99 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 360 6e-98 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 359 8e-98 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 358 1e-97 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 358 2e-97 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 357 4e-97 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 354 2e-96 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 354 3e-96 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 353 8e-96 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 352 1e-95 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 352 1e-95 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 350 6e-95 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 349 1e-94 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 349 1e-94 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 348 1e-94 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 348 3e-94 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 347 4e-94 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 347 5e-94 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 346 6e-94 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 346 9e-94 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 346 1e-93 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 345 2e-93 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 344 4e-93 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 343 4e-93 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 343 8e-93 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 341 2e-92 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 341 3e-92 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 340 4e-92 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 340 5e-92 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 340 5e-92 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 340 5e-92 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 339 6e-92 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 339 1e-91 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 338 2e-91 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 338 3e-91 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 337 4e-91 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 336 8e-91 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 336 9e-91 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 334 4e-90 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 333 7e-90 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 332 1e-89 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 331 3e-89 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 331 3e-89 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 330 5e-89 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 329 6e-89 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 329 1e-88 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 327 4e-88 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 327 4e-88 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 326 7e-88 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 326 8e-88 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 326 1e-87 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 326 1e-87 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 325 2e-87 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 324 3e-87 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 323 6e-87 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 323 7e-87 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 322 1e-86 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 321 2e-86 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 320 4e-86 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 319 1e-85 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 318 2e-85 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 315 1e-84 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 315 2e-84 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 315 2e-84 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 314 4e-84 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 313 5e-84 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 313 6e-84 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 313 7e-84 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 313 7e-84 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 313 8e-84 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 313 1e-83 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 313 1e-83 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 309 9e-83 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 308 3e-82 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 307 3e-82 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 307 5e-82 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 304 3e-81 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 304 4e-81 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 303 1e-80 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 302 1e-80 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 302 2e-80 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 300 4e-80 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 297 5e-79 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 295 2e-78 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 294 3e-78 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 293 5e-78 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 289 8e-77 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 287 3e-76 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 287 3e-76 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 287 4e-76 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 282 1e-74 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 276 1e-72 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 276 1e-72 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 275 1e-72 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 272 9e-72 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 272 2e-71 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 271 4e-71 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 268 2e-70 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 266 8e-70 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 264 3e-69 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 260 6e-68 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 258 3e-67 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 258 3e-67 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 256 1e-66 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 255 2e-66 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 255 2e-66 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 251 3e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 246 8e-64 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 243 8e-63 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 242 2e-62 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 236 1e-60 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 230 5e-59 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 230 6e-59 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 229 1e-58 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 211 3e-53 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 210 4e-53 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 200 6e-50 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 196 9e-49 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 195 2e-48 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 192 1e-47 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 191 4e-47 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 189 1e-46 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 185 2e-45 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 182 1e-44 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 182 2e-44 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 181 4e-44 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 181 4e-44 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 180 5e-44 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 171 4e-41 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 171 4e-41 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 170 7e-41 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 166 1e-39 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 166 1e-39 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 163 8e-39 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 163 9e-39 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 160 8e-38 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 147 5e-34 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 142 2e-32 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 141 3e-32 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 139 2e-31 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 133 1e-29 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 132 2e-29 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 129 2e-28 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 126 2e-27 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 121 4e-26 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 113 1e-23 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 105 4e-21 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 100 1e-19 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 98 6e-19 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 97 7e-19 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 94 6e-18 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 93 1e-17 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 93 2e-17 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 85 4e-15 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 84 6e-15 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 83 1e-14 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 82 3e-14 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 81 6e-14 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 80 1e-13 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 75 3e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 75 3e-12 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 73 1e-11 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 72 4e-11 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 68 4e-10 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 65 3e-09 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 65 4e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 65 4e-09 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 64 1e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 62 4e-08 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 60 1e-07 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 57 1e-06 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 55 3e-06 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 55 3e-06 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 50 2e-04 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 50 2e-04 UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 49 3e-04 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 47 0.001 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 46 0.002 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 45 0.004 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 45 0.007 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 44 0.008 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 44 0.009 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 44 0.009 UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 42 0.027 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 42 0.031 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 42 0.033 UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n... 42 0.034 UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot... 41 0.053 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 434 bits (1116), Expect = e-120, Method: Composition-based stats. Identities = 278/363 (76%), Positives = 311/363 (85%), Gaps = 2/363 (0%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIAAIPGDGIG EVLPEGIRVL+AAA + G AL F+ EWASC+YY HGKMMP Sbjct: 1 MPAHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMP 60 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW EQL ++DAIYFGAV WPD VPDHISLWGSLLKFRREFDQYVN+RPVRLFPGVPC L Sbjct: 61 DDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCAL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 A ++ GDIDF VVRENTEGEYSSLGG + E TE+E+VIQES+FTRRGVDRIL+YAF+LA+ Sbjct: 121 ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAE 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD- 238 R RK +TSATKSNG+AISMPYWD+R EAMA +YP + WDKQHIDILCARFV+QPERFD Sbjct: 181 KRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDV 240 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVVASNLFGDILSDLGPAC GTIGIAPSANLNPER FPSLFEPVHGSAPDI+GKNIANPI Sbjct: 241 VVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPI 300 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A IW+GA+ML+FLG GDER+Q+AH+ +L AIE VIA G TPDM G +T QV AI Sbjct: 301 AMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDMGGTLSTQQVGAAISDT 360 Query: 359 ILR 361 + R Sbjct: 361 LAR 363 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 432 bits (1110), Expect = e-119, Method: Composition-based stats. Identities = 254/360 (70%), Positives = 298/360 (82%), Gaps = 2/360 (0%) Query: 1 MMKT-MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIA IPGDGIG EV+PEG+R L A + R+G ++E +EWASC+YY+ HG+MMP Sbjct: 36 MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP 95 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW QLS DA+ FGAVGWP+TVPDHISLWGSL+KFRREFDQYVNLRP RLF GVPCPL Sbjct: 96 DDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPL 155 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 AG++ GDIDF +VRENTEGEYS++GG + EGTE E V+Q++VFTR G +R+L++AFELAQ Sbjct: 156 AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQ 215 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R K LT ATKSNG+AISMP+WD R MA YP++ WDKQHIDILCARFVMQP+RFDV Sbjct: 216 RRA-KRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDV 274 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 VVASNLFGDILSDLGPACTGTIGIAPSANLNPER FPSLFEPVHGSAPDI GK+IANPIA Sbjct: 275 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIA 334 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 IW+ AMM+DFLG G ++AH+ I+AAIE V+ HGP+T DM G A+T +V DAI + Sbjct: 335 MIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHL 394 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 413 bits (1061), Expect = e-114, Method: Composition-based stats. Identities = 223/359 (62%), Positives = 268/359 (74%), Gaps = 9/359 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +IA IPGDGIG EV+PEGIRVL+AA+ ++GF L+F +W SC Y G MMP D Sbjct: 5 QQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDW-SCARYHSQGSMMPSDG 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L DAI+ GAVG+P VPDH+SLW L+ RREFDQYVNLRPVRL PGVPCPLA K Sbjct: 64 IERLRDSDAIFLGAVGFP-GVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANK 122 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +PGDIDF++VRENTEGEYS +GGR+ GTEHE V QE++FTRRG DRI+RYAF+LA+ Sbjct: 123 KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFDLAKKLG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +TSATKSNG+ SMP+WDER A+ YP+IR D+ HIDIL ARF M PERFDVVV Sbjct: 183 RNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPERFDVVVG 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGP TGTI +APSAN+NPER +PS+FEPVHGSAPDI G+ IANPI IW Sbjct: 243 SNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIW 302 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA--HGPKTPDMKGNATTPQVADAICKII 359 +GAMML+ LG +A I+ AIE V+ TPD+ G A+T Q+ I + + Sbjct: 303 SGAMMLEHLGQ-----PEAAAAIMQAIETVLTHPDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 406 bits (1044), Expect = e-112, Method: Composition-based stats. Identities = 181/360 (50%), Positives = 243/360 (67%), Gaps = 8/360 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ +IAAIP DGIG EV+ G++VL+A +R G F++ E +W +YY +G MMP Sbjct: 1 MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDW-GSDYYKKNGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL +FDAI+FGAVG PD VPDHI+LWG L + FDQY N+RP ++ PG+ PL Sbjct: 60 DGLEQLKKFDAIFFGAVGAPD-VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLR 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 PGD+D+ +VREN+EGEYS GGR ++G EV + ++FTR GV RI+RYAF+LAQ+ Sbjct: 119 NCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQA 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN M WDE +++ +P++ WDK +D + R ++P+ D + Sbjct: 179 RPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++G+AP+AN++PER FPS+FEP+HGSA DI GK IANP+AT Sbjct: 239 VATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVAT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W A ML+ LG D A +++A+E V G TPD+ G A T QV DA+C+ I Sbjct: 299 FWTAAQMLEHLGEKD-----AATRLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAIA 353 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 173/359 (48%), Positives = 231/359 (64%), Gaps = 9/359 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 T RIA+IPGDGIG EV+ I+V++ A+ G F + F + W YY HG+ + +D Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPW-GTAYYKEHGRYVSEDC 104 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L +FDA FGAVG PD VPDHISLWG LL R Y N+RPVR FPG CPL Sbjct: 105 LDTLRKFDAGLFGAVGAPD-VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPL-NT 162 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ +VREN+EGEYS GGR + G E + ++FTR G++RI+R+AFE+AQSRP Sbjct: 163 ATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEVAQSRP 222 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK LT TKSN + M WD+ +A+++P++ WDK +D + R V +P+ D +V Sbjct: 223 RKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSIDTIVG 282 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NL DILSDL A G+IG+APS+NL+P R PS+FEPVHGSA DI GK +ANP+AT W Sbjct: 283 TNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFW 342 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + A ML +LG ++A ++ +E+V A G TPD+ G + T V DA+ K I R Sbjct: 343 SAAEMLSWLGE-----KEAAKQLMDCVEKVCAAGILTPDLGGTSNTQGVVDAVKKEIER 396 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 179/362 (49%), Positives = 229/362 (63%), Gaps = 9/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MKT RIA IPGDGIGKEV+P G + +Q AE G F F+ +W +YY HG MMP Sbjct: 1 MKTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGG-DYYRRHGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E L DAI FG+ G PD DHI+LWG LK + DQY N+RP RL PG+ PL Sbjct: 60 DGLEPLRDKDAILFGSAGDPDIA-DHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLK 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D+ +VREN+EGEYS +GGRV++G E S+ TR GV+RILRYAF LAQS Sbjct: 119 RCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFRLAQS 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN +M WDE ++ +P++RWDK+ +D AR V +P D + Sbjct: 179 RPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPASLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++GIAP+ N++PER PS+FEP+HGSA DI GK +ANPI T Sbjct: 239 VATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 W+ M+L+ LG QA ++ A+E V A T D+ G ATT QV A+C+ + Sbjct: 299 FWSVVMLLEHLGE-----HQAAARMMRAVESVTADQALHTRDLGGTATTEQVTQAVCQHL 353 Query: 360 LR 361 + Sbjct: 354 RQ 355 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 395 bits (1016), Expect = e-108, Method: Composition-based stats. Identities = 176/362 (48%), Positives = 241/362 (66%), Gaps = 10/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M+ RIA +PGDGIG EV+ E ++VL+ ++ + F + W S EYY HG+MMP+ Sbjct: 1 MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNS-EYYLQHGRMMPE 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + L +DAI FGA+G P VPD IS+W ++ R+ F QYVNLRPV+ G+P Sbjct: 60 NGLDILKNYDAILFGAIGDPR-VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFI 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 Q I+F +VREN EGEYS+ GGR+ +GT+ E+ +Q ++ TR+G +RI RYAF+ A+ Sbjct: 119 -HQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKK 177 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + +ATKSN + SM WDE +E +A YP+I+ +K +ID L A FV +P+ V+ Sbjct: 178 HGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDLG A G +GI+PSAN+NPE FPS+FEPVHGSAPDI GK ANPIA Sbjct: 238 VASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 IW+ A+ML LG D + IL AIE+V HG T D+ GN+TT ++ + I + I Sbjct: 298 IWSAALMLQSLGRED-----LASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQI 352 Query: 360 LR 361 ++ Sbjct: 353 VK 354 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 104/357 (29%), Positives = 167/357 (46%), Gaps = 27/357 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +A IPGDGIG E+ + + A + +E ++ + MP + Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTPRPTEDGRFR-MPQSSLDI 2032 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+EF+ Y N+RP + G P Sbjct: 2033 IRKHGIGLKGPLATPI----GKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYK----- 2083 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ++D VRENTEGEYS + + +G VV + T R+ R+AF+ A+ R++ Sbjct: 2084 NVDLVTVRENTEGEYSGIEHVIVDG----VVQSIKLITEEASRRVARFAFQYAKDNGRRS 2139 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + A ++ EI + +D +C V P RFDV+V NL Sbjct: 2140 VTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNL 2199 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI G++ ANP A +++ Sbjct: 2200 YGDILSDLAAGLIGGLGVTPSGNIGETG---AIFESVHGTAPDIAGQDRANPTALLFSAI 2256 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 MML ++ + + I +A+ I T D+ G +T Q IC+ I + Sbjct: 2257 MMLRYM-----NLNKHADLIESAVLATIREAKYLTADLGGRSTCSQYTKEICRQIEQ 2308 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 126/357 (35%), Positives = 180/357 (50%), Gaps = 27/357 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T +I IPGDGIG EV +RVL+A G +E A E Y + + +P + + Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA----TGLKFEWESFA-AGAEAYEKYKEYIPKELN 56 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G V P ++ R+ F+ Y N+RP+R PGV Sbjct: 57 ESIERTRIGLKGPVTTPI----GGGFSSINVELRKRFELYANVRPIRNLPGVHTRY---- 108 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D VVRENTEG YS + V G VV + T + RI ++AF A+ R Sbjct: 109 -PGVDLVVVRENTEGLYSGIEHEVVPG----VVESLKIITEKASTRISKFAFNYARKMGR 163 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K + S K+N + +S + +++ YPEI + + +D C + VM P ++D+++ Sbjct: 164 KKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLE 223 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SDL G +G+AP AN+ S+FE VHGSAPDI GKNIANP A I + Sbjct: 224 NLYGDIVSDLCAGLVGGLGLAPGANIGER---ASIFEAVHGSAPDIAGKNIANPTAVIRS 280 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 G +ML L D A N + AA+ V G T DM G +T + AD + + I Sbjct: 281 GILMLRHLDEQD-----AANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 389 bits (1000), Expect = e-107, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 182/355 (51%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIGKEV+ + +L+ + + A E +GK +PD+ E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKL----DLPFEYSYYD-AGDEALEKYGKALPDETLEA 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA+ FGA G +++ RRE + N+RP + G+ C Sbjct: 58 CRKSDAVLFGAAGETAA--------DVIVRLRRELGTFANVRPAKAIEGIECLY-----P 104 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D VVRENTE Y +V V TR +RI RYAFELA+ RK Sbjct: 105 GLDIVVVRENTECLYMGFEFGFG-----DVTEAIRVITREASERIARYAFELAKREGRKK 159 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A++YPEI+++ +ID C VM P RFDV+V +N+ Sbjct: 160 VTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDI+SDL G +G+APSAN+ ++FEPVHG+A DI GK IANP A I Sbjct: 220 FGDIVSDLAAGLVGGLGLAPSANVGER---TAIFEPVHGAAFDIAGKGIANPTAMILTAC 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML G +E + A+E+ I G KTPD+ GN T + A+ + ++ Sbjct: 277 MMLRHFGYVEE-----AKKVEEAVEKTIKEGKKTPDLGGNLKTMEFANEVASLLD 326 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 389 bits (1000), Expect = e-107, Method: Composition-based stats. Identities = 187/361 (51%), Positives = 244/361 (67%), Gaps = 11/361 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IAAIPGDG+GKEV+ +VL AAE G + SF W SC+YY HGKMMP+ Sbjct: 3 MKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPW-SCDYYLEHGKMMPE 61 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L++F+A++ GAVG P VPDHISLWG LLK RRE + +N+RP + G+ PL Sbjct: 62 DGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPL- 120 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 P D DF V+REN+EGEYS +GGR++ G + E+ IQ +VFTR+ +R++R+AFELA+ Sbjct: 121 -LHPNDFDFVVIRENSEGEYSEVGGRIHRG-DDEIAIQNAVFTRKATERVMRFAFELAKK 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R +TSATKSNG+ +MP+WDE + A +Y I QHID L A FV +PE FDV+ Sbjct: 179 R-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDIL+D+ + G+IGIAPSAN+NP +PS+FEPVHGSAPDI G+ +ANPI Sbjct: 238 VASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 IW +MLD G ++ IL +E+V A G KT D+ G +TT +V D IC + Sbjct: 298 IWTAKLMLDHFGE-----EELGAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEICSRLR 352 Query: 361 R 361 + Sbjct: 353 K 353 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 111/359 (30%), Positives = 170/359 (47%), Gaps = 32/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ IPGDGIG E+ RV A +EW + ++ G + + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKA---------PIEWETVVVDANTG--ISKE 69 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E +S+ G + P L R+ F+ Y N+RP PG Sbjct: 70 VIESISKNKIGLKGPISTPI----GTGHQSLNLGLRKTFNLYANIRPCLSIPGHKTRY-- 123 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +++ VVRENTEGEYS + + +G V + T+ RI YAF+ A + Sbjct: 124 ---NNVNTVVVRENTEGEYSGIENQPVKG----VAQSIKIITKEASTRIAHYAFQYALAN 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T K+N + S + + ++ YP I++++ ID C + V+ P + DV+V Sbjct: 177 GRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQMDVMV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDI+SDL G +G+ PS N+ + ++FE VHG+APDI GKN ANP A I Sbjct: 237 LPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGS--AIFEAVHGTAPDIAGKNKANPTALI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + MML LG+ E + I A+ + G T D+ GN++ + D + K I Sbjct: 295 LSSIMMLRHLGHFHE-----ASIIENAVLNTLTEGKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 388 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 180/359 (50%), Positives = 218/359 (60%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ IA IPGDGIG++V +VL A GF L+ W SC +Y G MMP D Sbjct: 1 MKSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPW-SCAFYKETGAMMPPD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L RFDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL GV PL Sbjct: 60 GIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLK- 118 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV++GT EV ++ S+FTR GV+RILR+ F+ A+ R Sbjct: 119 --AEGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQARQR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ L S TKSN SM WDE +A YP++ HID + AR VM PE DVVV Sbjct: 177 -RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLDVVV 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMMLD LG +A ++ A+E A G T G T + A+ + Sbjct: 296 WSGAMMLDHLGQ-----ARAARKVIEALERTTARGIGTVP--GKNRTETITAAVLAALD 347 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 108/361 (29%), Positives = 181/361 (50%), Gaps = 24/361 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M I+ + GDGIG E+ + +L+A + + +L +++E A + GK +PD Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLE-AGDAVLKNTGKALPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + DA VG S ++ RR D Y N+RP + +P +P Sbjct: 60 ETFEAIKNSDACLKAPVG--------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D+D +VRENTE Y+ + + + + + + RI YAF +A Sbjct: 110 ---RDDVDLVIVRENTEDLYTGEEFDIG-----DAAVAFRIISEKASKRIANYAFTIASK 161 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R K +T KSN + + + +A ++P++++++ ++D + QP+ FDV+ Sbjct: 162 RKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQLFDVI 221 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDILSD G +G+AP+AN+ LFEPVHG+A DI GK IANP + Sbjct: 222 VTTNLFGDILSDESAQVVGGLGMAPAANIGDN---FGLFEPVHGAAFDIAGKQIANPTSF 278 Query: 301 IWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 I + MMLD+LG + D++ + + + +++ + KT D+ G+ TT + I Sbjct: 279 ILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGDKTTMEFTKEIISR 338 Query: 359 I 359 + Sbjct: 339 L 339 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 167/361 (46%), Positives = 220/361 (60%), Gaps = 11/361 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +IA IPGDG G E + EG++VL AAA + GFAL ++W EYY G+++P Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGG-EYYLRTGEVLPP 71 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL R+DAIY GA+G P+ P I G LL+ R E DQY+NLRPV+L+PGV P+A Sbjct: 72 DAVEQLKRYDAIYLGAIGHPEVRP-GILEKGILLRLRFELDQYINLRPVKLYPGVETPIA 130 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 GK P DIDF VVRENTEG Y+ GG + GT EV IQ S+ TR+GV+R +R+AFE + Sbjct: 131 GKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAFEYCRK 190 Query: 181 R-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R+ +T K+N L + W+ + E YP+I D H+D +C V PE FDV Sbjct: 191 RGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNPEWFDV 250 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDI++DLG G +GIA NLNPE S+FEP+ GSAP GKN+ NP+A Sbjct: 251 IVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPE--GVSMFEPIGGSAPKYTGKNVINPLA 308 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA-TTPQVADAICKI 358 + AGAMML+ LG A I A+++V A K+ T +V D + Sbjct: 309 AVCAGAMMLEQLGETG-----AAARIEEAVKKVCAGHLKSLAAGRMGYGTDEVGDLVVSH 363 Query: 359 I 359 + Sbjct: 364 L 364 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 133/367 (36%), Positives = 192/367 (52%), Gaps = 18/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M++ +A + GDGIG EV+ E ++VL E++GF L+F + H G +P + Sbjct: 1 MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGG-AAIDHCGYPLPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + DAI FG+VG P PD G+LL R+ F + NLRP L+ G+ Sbjct: 60 TLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKF 119 Query: 117 CPLAGKQP-GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 CPL D VVRE T G Y V+ + ++RI R AF Sbjct: 120 CPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAF 179 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A R K +TS K+N L S+ W E V MA++YPE+ + +ID + + PE Sbjct: 180 EAAMKRN-KKVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPE 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDV++ SN+FGDI+SD TG++G+ PSA+LN L+EP GSAPDI GK IA Sbjct: 238 SFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNE--AGFGLYEPAGGSAPDIAGKGIA 295 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT---TPQVA 352 NPIA I + AMML + +A + I +A+++V+A G +T D+ ++T T ++ Sbjct: 296 NPIAQILSAAMMLRY----SFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMG 351 Query: 353 DAICKII 359 I + I Sbjct: 352 TLITQAI 358 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 126/366 (34%), Positives = 188/366 (51%), Gaps = 29/366 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 MM ++ I GDGIGKEV+PE I++L E A E +G +P+ Sbjct: 1 MM---KVCVIEGDGIGKEVIPEAIKILNELGEFEIIKGE------AGLECLKKYGNALPE 51 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP-----GV 115 D E+ D I FGA+ P + + ++ R+ F Y N+RP+ F G Sbjct: 52 DTIEKAKEADIILFGAITSPK-PGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGK 110 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 +ID ++RENTE Y E++ I E V TR+G +RI+R+AF Sbjct: 111 IADYEFLNAKNIDIVIIRENTEDLYVGRER-----LENDTAIAERVITRKGSERIIRFAF 165 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A RK ++ K+N L I+ + E + ++Y I D +D + PE Sbjct: 166 EYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPE 224 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V +N+FGDILSD A G +G+APSAN+ ++ +LFEPVHGSAPDI GK IA Sbjct: 225 KFDVIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK---ALFEPVHGSAPDIAGKGIA 281 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP+A+I + AM+ D++G ++ + I A++ + + TPD+ G+ T V D I Sbjct: 282 NPMASILSIAMLFDYIGEKEK-----GDLIREAVKYCLINKKVTPDLGGDLKTKDVGDEI 336 Query: 356 CKIILR 361 I + Sbjct: 337 LNYIRK 342 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 185/359 (51%), Positives = 233/359 (64%), Gaps = 12/359 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M MR+A IPGDGIG +V E ++V+ +A G + + + ++ SCE Y+ G MMP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA---TGGRIEWTEFDY-SCERYAKTGAMMPP 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L+ FDAI GAVG+P VPD +SLWG L+ RR F+QYVNLRPVRL PG+ PLA Sbjct: 57 DAPTTLAGFDAILLGAVGYP-GVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLA 115 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + +VRENTEGEYS +GG N G ++E +QESVFTR G +RI+RYAFELA S Sbjct: 116 GVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAFELAAS 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + SATKSNG+ SMPYWD +A YP+ H+D L AR V P DV+ Sbjct: 176 AGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPASLDVI 234 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDL A TG +G+A S N+NPERT S+FE VHGSAPDI G+ IANP+A Sbjct: 235 VASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQ 294 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I AGAM+LD L N I A+++V++ G +TPD+ G ATT Q+ AI + Sbjct: 295 ILAGAMLLDHLNE-----PATANKIRLAVDQVLSDGRVRTPDLGGTATTEQLGTAIAEA 348 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 125/359 (34%), Positives = 180/359 (50%), Gaps = 31/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+M+IA IPGDGIG EV+ + +L L F + A G +P++ Sbjct: 1 MKSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHAD-AGDACLKRTGTALPEE 55 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E + A FGA G S +++ RREFD + NLRPV+ PGVPC Sbjct: 56 TLEAVGEARATLFGAAG--------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY-- 105 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D+DF +VRENTE Y EG + + + TR RI ++AF+ AQ Sbjct: 106 ---PDLDFVIVRENTEDLYVGDEEYTPEG-----AVAKRIITRTASRRISQFAFQYAQKE 157 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + +T+ K+N L + + + +A YP++ ++D + QP+ F +V Sbjct: 158 GMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIV 217 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G +G+APSAN+ + +LFEPVHGSAP I GKNIANP A I Sbjct: 218 TTNLFGDILSDEAAGLIGGLGLAPSANIGEK---NALFEPVHGSAPQIAGKNIANPTAMI 274 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +ML L +Q I A+++ +A G TPD+ G T ++A I + + Sbjct: 275 LTTTLMLKHLNK-----KQEAQKIEKALQKTLAEGLVTPDLGGKLGTMEMAAEIARHLE 328 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 124/369 (33%), Positives = 180/369 (48%), Gaps = 20/369 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 199 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ GA+G H+ LL+ R + NLRP + P + Sbjct: 200 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLG-GRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D VVRE T G Y G E+ V+ +DRI R AFE Sbjct: 260 TLKKEVAEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFE 319 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 AQ R R L S K+N L SM W +RV AMA YP++ ++D + V P++ Sbjct: 320 TAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQ 377 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FD +V +N+FGDILSD TG+IG+ PSA++ P LFEP+HGSAPDI G++ AN Sbjct: 378 FDTIVTNNIFGDILSDEASMITGSIGMLPSASVGES--GPGLFEPIHGSAPDIAGQDKAN 435 Query: 297 PIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGN--ATTPQV 351 P+AT+ + AM+L + LG G+ A I A+ + + G +T D+ G ++ Sbjct: 436 PLATVLSAAMLLRYGLGEGN-----AAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEM 490 Query: 352 ADAICKIIL 360 + + K + Sbjct: 491 GEQVLKAVE 499 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 378 bits (972), Expect = e-103, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 171/366 (46%), Gaps = 30/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + GDGIG E++ + VL+ AA L E +E Y ++ + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D Q+ R A+ G V P + R+ Y N+RP + P Sbjct: 57 DTWSQIFRTKALLKGPVTTPQ----GGGYKSLNVTLRKTLGLYANVRPSCSY----FPFV 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +ID ++REN E Y+ + + + +R G ++I+R+AFE A Sbjct: 109 NTSAPEIDVVIIRENEEDLYAGIEY----HHTADTYESVKLISRSGSEKIIRFAFEYALK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RKT++ +K N + + + + +A Y I+ D IDI AR + P++FDV+ Sbjct: 165 NNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDILSD+ +G+IG+A SAN+ + ++FE VHGSAPDI G+NIANP Sbjct: 225 VTSNLYGDILSDIAAKISGSIGLAGSANIGKDY---AMFEAVHGSAPDIAGQNIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADA 354 + A MML LG + I A+++ I G T D+ + T + A A Sbjct: 282 LNAAIMMLVHLG-----LTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQA 336 Query: 355 ICKIIL 360 I + Sbjct: 337 IINNLE 342 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 175/358 (48%), Gaps = 15/358 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T I A+PGDGIG E+L + +L+ + ++ F E E+ G+ + + Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGG-ASIDTFGEPLTEKTL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC--PLAG 121 R DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKA 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++ D +VRE T G Y N + +TR ++RI+ AF+LA SR Sbjct: 121 ERVEGTDLVIVRELTSGIYFGEPRYFNNHE----ALDSLTYTREEIERIVHVAFKLAASR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS K N LA S W + V +++ YPE+ + +D + P++FDV+V Sbjct: 177 -RGKLTSVDKENVLASS-KLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ + + P L+EP+HGSAPDI GKN+ANP I Sbjct: 235 YENLFGDILSDEASVIPGSLGLSPSASFSND--GPRLYEPIHGSAPDIAGKNVANPFGMI 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + AM L A + + I +I HG T D+ G T + + + + + Sbjct: 293 LSLAMCLR----ESLNQPDAADELEQHIYNMIEHGQTTADLGGKLNTTDIFEILSQKL 346 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 133/356 (37%), Positives = 194/356 (54%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RI I GDGIG EV+P RVL+A G L F + E A E + G +P++ E Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA----TGLPLEFVEAE-AGWETFERRGTSVPEETVE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ A FGA P +G++ RR D Y N+RP + P Sbjct: 58 KILSCHATLFGAATSPTRKVPG--FFGAIRYLRRRLDLYANVRPAKSRP------VPGSR 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D +VRENTEG Y R +V I ++V +++ +RI R A +A+ RPRK Sbjct: 110 PGVDLVIVRENTEGLYVEQERRY-----LDVAIADAVISKKASERIGRAALRIAEGRPRK 164 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 TL A K+N L ++ + + V+ +A+++P + +D + VM+PERFDV+V +N Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GDILSDL G +G+APS N+ ++FEPVHGSAPDI GK IANP A I + Sbjct: 225 LLGDILSDLAAGLVGGLGLAPSGNIGD---TTAVFEPVHGSAPDIAGKGIANPTAAILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMMLD+LG ++A + A++ V+ GP+TPD+ G+ATT +A+ + + Sbjct: 282 AMMLDYLGE-----KEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALK 332 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 113/375 (30%), Positives = 173/375 (46%), Gaps = 41/375 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ IPGDGIG EV VL+A G L + ++E A E +G +P E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVE-AGVEVIEKYGTPLPPQVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G +G P + R+E D Y NLRP + PG+ P Sbjct: 58 SIRETRVAIKGPIGT----PVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF----- 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTE----------------HEVVIQESVFTRRGVD 168 DID VVRENTE Y+ + I + G Sbjct: 109 QDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSR 168 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 RI+++AFE A+ RK +T+ K+N + + + + +A+ YP+I ++ +D +C Sbjct: 169 RIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCL 228 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + +P+ +DV+V +NL+GDI+SDL G +G+AP AN+ ++FE +HGSAP Sbjct: 229 QLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD---GIAVFEAIHGSAPK 285 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM--KGN 345 G+N NP A I +GAMML +LG + + + VIA G T D+ Sbjct: 286 YAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAV-----QSVIAEGKYVTYDLAQGEP 340 Query: 346 ATTPQVADAICKIIL 360 T ++A+AI + Sbjct: 341 VGTQEMAEAIAARVQ 355 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 376 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 110/359 (30%), Positives = 172/359 (47%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + I GDGIG E+ + AA + +E ++ +PDD Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAA----NAPIKWEPVDVTPI--LKDGKTAIPDDAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G + P L RR F+ + N+RP R G P Sbjct: 108 ESVRRNYVALKGPLAT----PVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---- 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V +G VV + T+ +R+LR+AF+ A+S + Sbjct: 160 -DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITKEASERVLRFAFQYARSINK 214 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 K + K+ + +S + +A+++P++ +D + +D C + V P ++ V+V Sbjct: 215 KKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLV 274 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A + Sbjct: 275 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDE---CSIFEAVHGSAPDIAGKGLANPTALL 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +G + I AI + +A G T D+ G A T + A+AI K + Sbjct: 332 LSSIMMLQHMG-----LHEHAGRIQKAIFDTLAEGKALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 107/356 (30%), Positives = 170/356 (47%), Gaps = 26/356 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPGDGIG E+ +++ AA + +E+ + + M+P + E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQWEERNVTAIQGP-GGKWMIPSEAKES 87 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+ FD Y N+RP G P Sbjct: 88 MDKNKMGLKGPLKTPIAA----GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT----- 138 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D++ +RENTEGEYS + + +G VV + T RI +AFE A++ R Sbjct: 139 DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLITEGASKRIAEFAFEYARNNHRSN 194 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + ++ +AE+ +I++++ ++D +C V P +FDV+V NL Sbjct: 195 VTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNL 254 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI GK++ANP A + + Sbjct: 255 YGDILSDLCAGLIGGLGVTPSGNIGAN--GVAIFESVHGTAPDIAGKDMANPTALLLSAV 312 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 MML +G I AA I G T D+ GNA + IC+ + Sbjct: 313 MMLRHMG-----LFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVK 363 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 177/359 (49%), Positives = 224/359 (62%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT RIA +PGDGIG++V VL+ A GF+L + W SC+YY +G MMP D Sbjct: 1 MKTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPW-SCDYYLENGSMMPAD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL PGV PL Sbjct: 60 GIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPL-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGR+++G ++EV I+ ++FTR+GV+RILR+ FE A++R Sbjct: 118 -RSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQARAR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L S TKSN SM +WDE ++ YP++ HID + AR VM PE DVV Sbjct: 177 -RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLDVVA 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMML+ LG A ++ AIE A G + G T + ++ + Sbjct: 296 WSGAMMLEHLGET-----AAAEKVMDAIETTTARGV--GAIPGKDRTDAITASVLSALG 347 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 164/352 (46%), Positives = 224/352 (63%), Gaps = 12/352 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M + +PGDG+G EV+ E + L A +++ + W +++ HG MMP D + Sbjct: 1 MNVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPW-GSAWWAEHGTMMPADAID 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L DAI GAVG P VPD +LWG +LK R+E D +VN+RP RL G+P PLAG+ P Sbjct: 56 VLRGHDAILMGAVGDP-AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAP 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D+D VREN+EGEY+ +GGRV+ G H+V I+ SVFTRRG +R++RYAF +A +R + Sbjct: 115 HDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASAR-KG 173 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L +ATKSN P+WDE V + +P + D+ +D L AR + P DVVVASN Sbjct: 174 VLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVVASN 233 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDIL+D+ A G +G+A SANL+P P+LFEPVHGSAPDI G+ IANP+ IW+ Sbjct: 234 LFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSA 293 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A+ML+ LG G + ++ A+E V GP+T D+ G ATT +V DA+ Sbjct: 294 ALMLEQLGAG-----EGSRRLMDALETVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 144/359 (40%), Positives = 195/359 (54%), Gaps = 24/359 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +I I GDGIG EV+P VL+A G F + + A E + G +P+ Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA----TGLKFEFVEAQ-AGWETFERIGTSVPE 55 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E ++ DA FGA P +G++ RR+ D + N+RP + P Sbjct: 56 ATLEAVTHTDATLFGAATSPTKKVPG--FFGAIRYMRRKLDLFANVRPAKHHP------V 107 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D VVRENTEG Y EG E+ I ++V TR+ RI YA LA S Sbjct: 108 PGSRPGVDLIVVRENTEGLYVEQERSYLEG---EIAIADTVITRKASARIGEYAARLAAS 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK L A K+N L ++ + V A A +PE++ ID + V PERFDV+ Sbjct: 165 RPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPERFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDI+SDL G +GIA S N+ + ++FEPVHGSAPDI GK IANP AT Sbjct: 225 VTTNLFGDIISDLTAGLVGGLGIAASGNIGIKH---AVFEPVHGSAPDIAGKGIANPAAT 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 I +G MMLD LG +A + AA+++V+ GP+TPD+ GNATT Q A+A+ + + Sbjct: 282 ILSGVMMLDHLGE-----HEAARRVEAAVDKVLQEGPRTPDLGGNATTLQFAEAVARSL 335 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 117/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ R+++A G + +E + + +PDD E + Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + G + P + + R+ F+ + N+RPVR P VP P G + Sbjct: 79 KRTRVVLKGPLET----PVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG---RN 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+++ R G V I + + +G ++I+R+AFELA++ RK + Sbjct: 132 IDLVVVRENIEDLYAAIEYRETPG----VTIAHKLISYKGSEKIIRFAFELARAEGRKKV 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T ATKSN L ++ ++ E +A YP+I + ID + V PE+F+V+V +NL Sbjct: 188 TCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLN 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDI+SDL G +G A S N E ++FEPVHG+AP GKN+ NP A I M Sbjct: 248 GDIISDLASGLVGGLGFAASGNYGHE---VAIFEPVHGTAPKYAGKNVINPTAMILTAVM 304 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGN---ATTPQVADAICKIILR 361 ML ++ + I A+ + G T D+ G+ +T DAI + R Sbjct: 305 MLRYIDEFET-----AETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGR 358 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 102/358 (28%), Positives = 165/358 (46%), Gaps = 27/358 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + ++ PG GIG E+ + AA + +E E + G ++ ++ Sbjct: 303 QNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEA-GDLIKEES 357 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G P + R++ + + N+RP R GV P + Sbjct: 358 LNAVINYKWGLKGPFATPI----GKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYS-- 411 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +RENTEGEYS L V G VV + ++ + I RYAFE A+ Sbjct: 412 ---NVDLVTIRENTEGEYSGLEHAVVPG----VVENLKIISQPACENIARYAFEFARKNN 464 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK + + K+ + + + ++ YPEI + ++ ID +C + PE FDV+V Sbjct: 465 RKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEVFDVMVM 524 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDI+SDL G +G+ S N++ +++E VHG+APDI G N ANP A + Sbjct: 525 PNLYGDIVSDLCAGLIGGLGLTASGNIS---HTCAVYEAVHGTAPDIAGLNKANPTALLL 581 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 +G MML +G Q+ I A+ + ++ G T D+ G ATT A+ I Sbjct: 582 SGVMMLKAMG-----LQKEGFAIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 123/367 (33%), Positives = 175/367 (47%), Gaps = 21/367 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA + GDGIG EV+ E +VL A ++ F ++ + + +HG +PD Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGG-AAIDNHGNALPDSTMAG 61 Query: 66 LSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL--- 119 DAI FG+VG P P +LL R FD + N+RP L P + Sbjct: 62 CIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLR 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + D V+RE T Y E E ++RR V RI AF+ AQ Sbjct: 122 SDISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQ 181 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R +TS K+N LA S W + VE +A YP++ + ++D + V P +FDV Sbjct: 182 KRN-NKVTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 ++ NLFGDILSD+ TG++G+ PSA+LN + ++EP GSAPDI G +ANPIA Sbjct: 240 MLCPNLFGDILSDICAMITGSMGLLPSASLNSD--GFGMYEPAGGSAPDIAGLGVANPIA 297 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVAD 353 I + A+ML + A I A+ + +G T D+ K +T +V D Sbjct: 298 QILSAALMLRY----SLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGD 353 Query: 354 AICKIIL 360 ICK I Sbjct: 354 YICKQIE 360 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 179/322 (55%), Positives = 212/322 (65%), Gaps = 6/322 (1%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT +A IPGDGIG +V + VL AAA + FA W SCEYY HG+MMP+D Sbjct: 1 MKTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPW-SCEYYLEHGRMMPED 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAIY GAVGWP TVPD +SL G LL R+ F+QY N+RP RL GV PL Sbjct: 59 GIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV+EG +EV ++ SVFTR GV+RILR+ FE A+SR Sbjct: 118 --AEGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQARSR 175 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS TKSN SM +WDE +A YP++ HID + A+ VM P+ DVVV Sbjct: 176 -RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLDVVV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI GKNIANPIA I Sbjct: 235 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHN 323 W+ A MLD LG + Sbjct: 295 WSVAQMLDHLGEAEVSAAVLSA 316 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 369 bits (947), Expect = e-101, Method: Composition-based stats. Identities = 159/356 (44%), Positives = 226/356 (63%), Gaps = 15/356 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +I IPGDGIG EV+ E ++ Q+ + + ++W ++Y GK++P D+ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL----NLPIQRDYVDW-GIQHYLKTGKVVPIDYI 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 +Q+ ++DAI G++G P T+PD+++L L++ R++ DQ++ LRP + FPG+P PL Sbjct: 65 DQVKQYDAILLGSLGDPRTLPDYVTLE-PLIQMRQQLDQFLCLRPAKHFPGIPTPLKKC- 122 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +ID VVREN+EGEYS++GG GT E I+ +V TRRG++R++RYAFE ++ R R Sbjct: 123 --EIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEASRKR-R 179 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T ATKSN + M WD EA+A YP++ +K ++D L A V P +FDV+V S Sbjct: 180 NHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGS 239 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLF DI+SDL G++GIAPSAN+NPERTFPSLFEPVHGSA DI GK I +PI T+ A Sbjct: 240 NLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRA 299 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +MML+FLG +E I AI+ I T D+ G TT +V + I I Sbjct: 300 SSMMLEFLGYSEESV-----LIEEAIQSSILQKITTIDIGGTKTTNEVGNFIADYI 350 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 121/360 (33%), Positives = 181/360 (50%), Gaps = 19/360 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M++A +PGDGIG EV ++VL+A E G L++E + G+ P+ + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGG-AAIDAFGEPFPEPTRK 59 Query: 65 QLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 + +A+ G+VG P P I LL R+ D + NLRP ++FPG+ PL Sbjct: 60 GVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D +VRE T G Y G +++ V+R+ R AFE A+ Sbjct: 120 EEIARGVDVLIVRELTGGIYFGEP----RGMSEAEAWNTERYSKPEVERVARVAFEAARK 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R RK + S K+N L + +W + VE + YP++ + Q++D + V P RFDVV Sbjct: 176 R-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVV 233 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V N+FGDILSDL G++G+ PSA+L +FEPVHGSAPDI GK IANP A Sbjct: 234 VTGNIFGDILSDLASVLPGSLGLLPSASLG---RGTPVFEPVHGSAPDIAGKGIANPTAA 290 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 I + AMML+ + + A+ + + P PD+ G+A T + + + Sbjct: 291 ILSAAMMLEHA----FGLVELARKVEDAVAKALLETP-PPDLGGSAGTEAFTATVLRHLA 345 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 126/364 (34%), Positives = 187/364 (51%), Gaps = 18/364 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I IPGDGIGKE+ + VL+ E++G LS+ + A Y G +PDD Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKD-AGGTAYDKFGTPLPDDTI 60 Query: 64 EQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 E D + FGAVG V + ++L R+ Y NLRPV++ + PL Sbjct: 61 EACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +D +VRE G Y + E ++ VDRI + AFE A+ Sbjct: 121 KPELVKGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETAK 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R +TS K+N LA S W V +AE+YP++ + ++D + ++P +FDV Sbjct: 181 LR-RGKVTSVDKANVLATSR-LWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDV 238 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V NLFGDILSD G+IG+ PSA++ T SL+EP+HGSAPDI GK IANP+ Sbjct: 239 IVTGNLFGDILSDEAAVVGGSIGMMPSASIG---TSTSLYEPIHGSAPDIAGKGIANPMG 295 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KG--NATTPQVADAI 355 TI + AM+L + + + + + A +A G +TPD+ +G A T ++ I Sbjct: 296 TILSAAMLLRYSLHEEAAAKAIEAAVDKA----LADGYRTPDLWKEGFQKANTEEITKVI 351 Query: 356 CKII 359 C+ I Sbjct: 352 CERI 355 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 125/366 (34%), Positives = 193/366 (52%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA +PGDGIG EV+ E ++VL+ ++ G + G+ +P++ + Sbjct: 1 MKIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGG-DAIDRFGEPLPEETKK 59 Query: 65 QLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 DAI+ G+VG P P+ G LL R+ + Y N+RP++++ + PL Sbjct: 60 ICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPL 119 Query: 120 AGKQPG-DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 K G +D VRE + G Y G + E ++ R+ V+RI R AFE+A Sbjct: 120 KEKVIGSGVDLVTVRELSYGVYYGQP----RGLDEEKGFDTMIYDRKTVERIARTAFEIA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R RK +TS K+N L SM W + V +A YP++ ++D + +++P +FD Sbjct: 176 KNR-RKKVTSVDKANVLYSSM-LWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ +N+FGDILSD A G++G+ PSA+ + L+EP GSAPDI GKNIANPI Sbjct: 234 VILTTNMFGDILSDESAALPGSLGLLPSASFGDKN----LYEPAGGSAPDIAGKNIANPI 289 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVADA 354 A I + AMML+ + I A+E VI G +T D+ + +T Q+ D Sbjct: 290 AQILSLAMMLEH----SFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDL 345 Query: 355 ICKIIL 360 ICK + Sbjct: 346 ICKKLE 351 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 116/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG E + ++VL+AA L++E E + + +P + E + Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + G + P + + R+ F+ Y N+RPVR FP VP P AG Sbjct: 78 RKTRVVLKGPL----ETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG---RG 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+ + V + + +G ++I+R+AFELA++ RK + Sbjct: 131 IDLVVVRENVEDLYAGIEHMQTP----SVAQTLKLISWKGSEKIVRFAFELARAEGRKKV 186 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 ATKSN + ++ E +A+ YP+I +D + V +PE+F+V+V +N+ Sbjct: 187 HCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMN 246 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSDL G +G APSAN+ E ++FE VHGSAP GKN+ NP A + + M Sbjct: 247 GDILSDLTSGLIGGLGFAPSANIGNE---VAIFEAVHGSAPKYAGKNVINPTAVLLSAVM 303 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVADAICKIILR 361 ML +L + I A+ + G T D+ G A T + +AI + + + Sbjct: 304 MLRYLEEF-----ATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 160/355 (45%), Gaps = 13/355 (3%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI + GDG+G EV+ VL +G + + G+ +P Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGV-AIDLTGQPLPQRTLAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 DA+ GAVG P LL R+ + N+RPV + K Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +IDF VVRE T G Y S EV + R ++RI+ YAF+LA R +K Sbjct: 123 EIDFVVVRELTGGIYFSYPKERT----EEVATDTLTYHRHEIERIVSYAFQLANKR-KKK 177 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +TS K+N L S W E +A YP + + +D + P RFDV+V NL Sbjct: 178 VTSIDKANVLESS-KLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTENL 236 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSD G++G+ PSA+ PSL+EP+HGSAPDI GKN ANPIA + + A Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAE--KGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML + I A+ V+ G T D+ G TT A+ + + Sbjct: 295 MML----GQSFGLTREGYAIEEAVSAVLKSGKCTADIGGTETTTSFTKAVIQEME 345 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 366 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 118/358 (32%), Positives = 182/358 (50%), Gaps = 23/358 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K R+A I GDG+G +V+ + VL A +++ + + A +G +P + Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPA-VAGLNTVEKYGTNLPKET 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L D + G P+ SL + + R+ FD Y ++RP + P VP Sbjct: 63 LDTLKETDCVLKGPTTTPE---GANSLPSANVGIRKYFDLYADVRPNKTLPNVPS----- 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +VRENTEG YS L RVN E I V TR+ +RI++YAF+LA+SR Sbjct: 115 IKPNVDMVIVRENTEGMYSGLDFRVN----QETTIGIRVITRKACERIVKYAFKLAESR- 169 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +K +T K N L +S + + A+ +P+++ D H+D + F+ QPE +DV+V Sbjct: 170 KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFYDVIVT 229 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI+SD G IG SAN+ + ++FEP+HGS P G + NPI TI Sbjct: 230 ENLFGDIISDEAAMVVGGIGTGASANIGDKY---AMFEPIHGSVPKYTGMDKVNPIGTIM 286 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 + MMLD++ ++A I A+ +V+ G T D+ G A +V I + Sbjct: 287 SVKMMLDWMDY-----KEAGKAIEDAVYKVLEEGKILTYDLGGTAKCSEVGKEIASKV 339 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 365 bits (937), Expect = 1e-99, Method: Composition-based stats. Identities = 155/384 (40%), Positives = 219/384 (57%), Gaps = 32/384 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ I GDGIG EV+ EG +V+ AA E + F + + M + S ++Y G+ + + Sbjct: 1 MVSYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPF-SADHYVKTGETISES 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++LS++ AI+ G++G V + G LL R +DQYVNLRPV+L GV PL G Sbjct: 60 SLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-----------------------HEVVIQ 158 K DIDFYVVRENTE Y +GGR +GT E+ Q Sbjct: 120 KTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQ 179 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 V ++ G RI+ Y+F+LA SRP+K L+S K+N L +W E A YP+++ Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 D ++D + FV PE FDVVV+ N+FGDI++DLG G +G+AP N+NPE S+ Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPE--GTSM 297 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GP 337 FEP+ GSAP G N NPIATIWAGAM+L+ LG +QA GI+ AIE+ + Sbjct: 298 FEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGE-----KQAAAGIVDAIEQNLKEKKI 352 Query: 338 KTPDMKGNATTPQVADAICKIILR 361 +T D+ G+A T V I +I+ + Sbjct: 353 RTYDLGGSAGTSDVGTDIARIVKQ 376 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 107/367 (29%), Positives = 170/367 (46%), Gaps = 30/367 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + I GDGIG E++ + +L+ A R + E +E Y H+ + + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E + R I + P + R+ + N+RP F P Sbjct: 57 QSWESIERTGVILKAPITTPQ----GGGYKSLNVTIRKTLQLFANIRPSVSFY----PFT 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +++ ++REN E Y+ + R H + + +R G ++I+RYAFE A Sbjct: 109 KTLHPNLNLTIIRENEEDLYAGIEYRQT----HNMYESVKLISRTGCEKIIRYAFEYAVK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T +K N + S + + +A+ YP+I + IDI AR +PE FDV+ Sbjct: 165 NNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDI+SD+ +G++G+A SAN+ ++FE VHGSAPDI G++IANP Sbjct: 225 VTSNLYGDIISDVAAEISGSVGLAGSANIGEHY---AMFEAVHGSAPDIAGQDIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADA 354 + A MML +G GD I A ++ I G T D+ T + A+ Sbjct: 282 LNAAIMMLVHIGQGD-----IATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAEE 336 Query: 355 ICKIILR 361 + K + + Sbjct: 337 VVKRLGQ 343 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 122/363 (33%), Positives = 185/363 (50%), Gaps = 13/363 (3%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T+ IA +PGDGIG+EV+P + ++ AA G Q A +YY+ G +P Sbjct: 7 TLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPASTL 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + + DAI FGA+GWPD + L R E + +RP+R FPG+P L + Sbjct: 67 DACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPR 126 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 IDF +VRE TEG + + G E E TR G R+ +AF++A+ R R Sbjct: 127 AEQIDFVLVREQTEGLFYARGR--GEIRNDEEAYDTMQITRSGTQRVTEFAFDIARQRKR 184 Query: 184 K----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + +T K+N SM ++ + + +A+ + ++ D ++D L V +P FDV Sbjct: 185 RGKPGNVTCVDKANVF-QSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKPWTFDV 243 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+APSA++ + LF+P HG+APDI GK ANP A Sbjct: 244 LVTENMFGDILSDLAAGLIGGMGMAPSADIGDKH---GLFQPAHGTAPDIAGKGCANPSA 300 Query: 300 TIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAIC 356 + AMMLD+L G A + A+E ++ P + GNA ++ ++ Sbjct: 301 MFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPMEYGGNANCAEMTRSVI 360 Query: 357 KII 359 + Sbjct: 361 SSL 363 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 364 bits (935), Expect = 2e-99, Method: Composition-based stats. Identities = 151/359 (42%), Positives = 208/359 (57%), Gaps = 11/359 (3%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +R+A IPGDGIG EV+ + L+AA E G L +W E Y G MP D Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGG-ERYLRQGAAMPPDA 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + DA+ FGAVG PD VP+H +WG ++ R++ D VNLRPVR FPGVP + Sbjct: 65 ADLVKKTDAVLFGAVGRPD-VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +VRENTEGEY GG + G+ H++ I+ +V +RR ++R AF LA R Sbjct: 124 --DGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFALAGRRS 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L TKSN + P WD V + E YP + + +D + AR + P DV++A Sbjct: 182 -GRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLA 240 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDL G +G+APSAN+ P+ P ++EPVHGSAPDI GK +ANP+A + Sbjct: 241 SNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIIL 360 +GAM+L+ LG+ D A + A+ + + T D+ GNATT VA A+ + Sbjct: 301 SGAMLLEDLGHTD-----AARRVRDAVADTLRDTRHHTADLGGNATTADVASAVLHTME 354 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 364 bits (934), Expect = 3e-99, Method: Composition-based stats. Identities = 135/371 (36%), Positives = 188/371 (50%), Gaps = 29/371 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 I IPGDGIG+EV+P + VL+A G FE + A E + G+ +P Sbjct: 4 APYTILVIPGDGIGREVIPAAVAVLRA----TGLPFHFENAD-AGWECFQRQGEALPSAT 58 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI FGAV P +++ RRE D Y N+RPV F +P + Sbjct: 59 LTAARAADAILFGAVASPGYPVAG--YRSPIVRLRRELDLYANIRPV--FDDLPENGSNP 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR- 181 + +D VVRENTE Y+ ++G I E V TRR RI+R A +LA++R Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGAT---AIAERVITRRASARIMRVACDLARARR 171 Query: 182 --------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 P +T K+N L + + +A+ YP+++ D+ +D + + Sbjct: 172 SARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATR 231 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 PERFDV+V +NLFGDILSD+ A G +G+APSANL +LFEPVHG+APDI GK Sbjct: 232 PERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH---ALFEPVHGAAPDIAGKG 288 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAH-----NGILAAIEEVIAHGPKTPDMKGNATT 348 IANP+A I A++LD L + I AI V A GP TPD+ G+A T Sbjct: 289 IANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVT 348 Query: 349 PQVADAICKII 359 + +A+ + Sbjct: 349 TDITNAVLSHM 359 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 364 bits (934), Expect = 3e-99, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 186/355 (52%), Gaps = 29/355 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A I GDGIG+E++P ++VL A +G +E + G + ++ E Sbjct: 1 MRLAVIEGDGIGREIIPAAVKVLDA----FGLEFEKVPLEL-GYTRWERTGTAISNNDLE 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA+ FGA+ + LL R+E D Y N+RPV+ PG+ Sbjct: 56 TIKGCDAVLFGAITT----VPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGV---TGR 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D DF +VRENTEG YS + E+ + V TR+G +RI YA +LA+ R + Sbjct: 109 NDFDFIIVRENTEGLYSGIE-----EIGPELSWTKRVVTRKGSERIAEYACKLAKKR-KN 162 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT KSN L S + + A + ++ +D + +M+PER+D+VV +N Sbjct: 163 KLTIVHKSNVLK-SDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVTTN 220 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSD+ A G++G+ PSAN+ + + FEPVHGSAPDI GK IANP+A I Sbjct: 221 LFGDILSDMCAALVGSLGLVPSANIGEKY---AFFEPVHGSAPDIAGKGIANPLAAILCV 277 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L+++G I AI V+ TPD+ G A+T +V +A+ + + Sbjct: 278 KMLLEWMGEPR------SQIIDEAIAYVLQKKIITPDLGGTASTMEVGNAVAEYV 326 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 106/366 (28%), Positives = 164/366 (44%), Gaps = 30/366 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK + I GDGIG E++ ++V+ A G L E++E Y + + Sbjct: 1 MKKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVYSMGNPSGIEPS 56 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L R + P + R+ Y N+RP + P Sbjct: 57 SWESLKRTKVFLKAPITTPQ----GGGFKSLNVTVRKALGLYANIRPCISY----APFIH 108 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + ID ++REN E Y + R + + TR+G +RI+RYAFE A+ Sbjct: 109 TKHPGIDLVIIRENEEDLYGGIEHRQ----GVDSFQALKIMTRQGTERIIRYAFEYARCY 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK ++S TK N L I+ + + E +A+ YP+I + IDI A+ P+ FDV+V Sbjct: 165 GRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQSFDVLV 224 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NL+GDILSD+ G++G+ SAN+ E S+FE +HGSAP G+N+ANP + Sbjct: 225 LANLYGDILSDVAVQIAGSVGLGASANIGHEY---SMFEAIHGSAPRRAGQNVANPSGLL 281 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAI 355 A ML +G + + A + I G T D+ T + A + Sbjct: 282 LAAVQMLIHIGQ-----NAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREFARHV 336 Query: 356 CKIILR 361 K + + Sbjct: 337 IKNLGK 342 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 363 bits (932), Expect = 5e-99, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 178/367 (48%), Gaps = 18/367 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDGIG EV+ VLQ A G F++M G +P++ Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGG-AALDLVGVPLPEET 103 Query: 63 HEQLSRFDAIYFGAVGWPDTVP--DHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 DAI GA+G H+ +L RR+ + NLRP + P + Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDAST 163 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVN-EGTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + EV + ++ +DRI R AFE Sbjct: 164 LKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFET 223 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R R L S K+N L S+ W +RV A+A YP++ ++D + + P++F Sbjct: 224 ARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +N+FGDILSD TG+IG+ PSA+L P LFEP+HGSAPDI G++ ANP Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGES--GPGLFEPIHGSAPDIAGQDKANP 339 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVAD 353 +ATI + AM+L + ++A I A+ + + G +T D+ ++ + Sbjct: 340 LATILSAAMLLKY----GLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGE 395 Query: 354 AICKIIL 360 + K + Sbjct: 396 EVLKSVE 402 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 363 bits (931), Expect = 8e-99, Method: Composition-based stats. Identities = 102/364 (28%), Positives = 167/364 (45%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG E+ + +L AA G L E +E Y + +P + Sbjct: 20 TPIPVTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEA 75 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + ++R + G + P + R+ Y N+RP R + P+ Sbjct: 76 WDSIARTRVMLKGPITTPQ----GGGYKSLNVTMRKTLGLYANVRPCRTYK----PIVTT 127 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + D+D +VREN E Y+ + R +V + TR G +RI RYAFE A+ Sbjct: 128 RHPDMDVVIVRENEEDLYAGIEHRQT----QDVAQCLKLITRSGSERIARYAFEYARQHG 183 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T K N + ++ + + +A YPEI+ Q +D A FV +PE +DVV+ Sbjct: 184 RSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVLL 243 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDILSD+ TG++G+ S N+ + ++FE +HGSAPD+ +++ANP + Sbjct: 244 PNLYGDILSDIAAQMTGSVGLGGSVNIG---SGGAIFEAIHGSAPDLA-RDVANPSGLLL 299 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG-----NATTPQVADAICK 357 A ML L + ++ A + G T D+ G A T + +A+ + Sbjct: 300 AAVEMLRHL-----KLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVIE 354 Query: 358 IILR 361 + R Sbjct: 355 RLGR 358 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 360 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 106/350 (30%), Positives = 168/350 (48%), Gaps = 15/350 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I A+PGDGIG E+L + +L+ +E++ F E + ++G + ++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVS-IDYYGTPLTNETL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAG 121 + DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 QSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQ 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +VRE T G Y V + + ++ + ++RI+R AF LA R Sbjct: 121 DIVEGTDLVIVRELTSGIYFGEPSYVKKTE----ALDSLKYSSQEIERIVRIAFNLANRR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK LTS K N L S W + V + ++YPE+ + +D + QP +FDV+V Sbjct: 177 -RKKLTSVDKENVL-SSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ +T L+EP+HGSAPDI ++ ANP + Sbjct: 235 TENLFGDILSDEASVIPGSLGLSPSASFG--QTGTRLYEPIHGSAPDIANEDKANPFGMV 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 + A+ L A N + + + I T D+ G T ++ Sbjct: 293 LSLALCLR----ESLNQNDAANELESIVYSFIQSNKTTADLGGQYRTSEI 338 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 164/358 (45%), Positives = 212/358 (59%), Gaps = 10/358 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+++A IPGDGIG EV+ EG++VL A A R G L + E + + G+++PD Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYEL-GAQRWHATGEVLPDAV 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L + DAI GAVG P TVP + G LL+ R F YVNLRPVRL+PGV PLAG Sbjct: 63 EEELRQHDAILLGAVGDP-TVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGV 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 P DID VVRE TEG Y+ +GG + +GT HE+ Q+SV TR GV+R++RYAF A RP Sbjct: 122 APEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERP 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 LT K N L + W V + YP++ D H+D FV QP RFDVVV Sbjct: 182 CHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVT 241 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI++DLG A G IG+A S N+NPE FPS+FEPVHGSAPDI G+ A+P ATI Sbjct: 242 DNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + ++ML+ LG D Q E G + +T Q+ D I + + Sbjct: 302 SVSLMLEHLGYADAAAQIDQAVAEDLQERAKNGGVR--------STTQIGDDIAQRVA 351 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 121/366 (33%), Positives = 195/366 (53%), Gaps = 22/366 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK I I GDGIG EV+ + I+ L + R+ S++ + A + G MP + Sbjct: 1 MKK-NIVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNV-LAGAKAIETFGDPMPKE 58 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-PCP 118 + + DA+ FG++G P D+ P + LLK R+E D Y N+RP+ +PG+ P Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSP 118 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + ++ ++F + RE T G Y GR G E V++ + ++RI +F+ A Sbjct: 119 IKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSFKAA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +SR RK +T K+N L S W E ++ MA +Y ++ + +ID + ++ P +FD Sbjct: 176 RSRNRK-MTLVDKANVLETSR-LWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ N+FGDILSD T ++G+ PSA++ ++ SLFEP+HGS P GKNIANP+ Sbjct: 234 VILTDNMFGDILSDEASILTSSLGLLPSASIGSKK---SLFEPIHGSYPQAKGKNIANPL 290 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 I + +MML++ Q N + A++ I TPD+ + +++T +V D Sbjct: 291 GCILSVSMMLEYF-----EMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDY 345 Query: 355 ICKIIL 360 I K I Sbjct: 346 IEKYIK 351 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 104/361 (28%), Positives = 170/361 (47%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDGIG E+ ++ AA + +E + + + + +PD Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAA----NVPIEWESCDVSPI--FVNGLTTIPDPAV 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + +++ G + P L R+ F + N+RP + G Sbjct: 90 QSITKNLVALKGPLATPI----GKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---- 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V G VV + TR +R++RYAFE A++ R Sbjct: 142 -ENVDLVLIRENTEGEYSGIEHIVCPG----VVQSIKLITRDASERVIRYAFEYARAIGR 196 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 + KS ++ + + +++ YP++ + + ID + V P + V V Sbjct: 197 PRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSV 256 Query: 242 ASNLFGDILSDLGPAC-TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 NL+GDILSDL G++G+ PSAN+ + S+FE VHGSAPDI G++ ANP A Sbjct: 257 CPNLYGDILSDLNSGLSAGSLGLTPSANIGHK---ISIFEAVHGSAPDIAGQDKANPTAL 313 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP--KTPDMKGNATTPQVADAICKI 358 + + MML+ +G + I A+ IA GP +T D+ G ATT +A+ K Sbjct: 314 LLSSVMMLNHMG-----LTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKR 368 Query: 359 I 359 + Sbjct: 369 L 369 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 117/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M IA +PGDGIG E + ++L +++ + + + + + G P Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGG-DAINSEGTPFPK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 + + +AI FGAVG P G+LL R+ F+ + NLRP+ L + Sbjct: 60 STLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKE 119 Query: 117 -CPLA-GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL P ID VRE T G Y + +E +V+ R ++RI A Sbjct: 120 LSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LAQ R RK ++S K+N L SM W E V +A+NYP++ + +ID + + P Sbjct: 180 FKLAQKR-RKRVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNASMQLINNP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 +FD+++ NLFGDILSD +G+IG+ PSA++N L+EP GSAPDI KNI Sbjct: 238 SKFDIILCPNLFGDILSDECAMISGSIGMLPSASINEH--NFGLYEPAGGSAPDIAEKNI 295 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----TTPQ 350 ANPIA I + A++ + + I A+ + + G +T D+ +T + Sbjct: 296 ANPIAHILSIALLFRY----SLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNE 351 Query: 351 VADAICKIIL 360 + D I +I Sbjct: 352 MGDIIAALIK 361 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 132/368 (35%), Positives = 195/368 (52%), Gaps = 29/368 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K++ I IPGDGIGKEV+P G +VL+ + G + +F +A + + GK +PD+ Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFID-LYAGFQTFQETGKALPDET 80 Query: 63 HEQLSR-FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L FGAV P T + S ++ RRE + N+RPV+ G Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKVEGYS--SPIVALRREMGLFANVRPVKSVEG------- 131 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ ID +VRENTE Y + +++ T V + RI A ++A Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191 Query: 181 R----PRKTLTSATKSNGLAISMPYWDERVEAMAE----NYPEIRWDKQHIDILCARFVM 232 R + TLT KSN L+ S + E + + E Y +I++++Q +D + R Sbjct: 192 RLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFR 251 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 +P+ FDV+VA NL+GDILSD A G++G+ PSAN+ PE + EP HGSAPDI GK Sbjct: 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGK 308 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQV 351 IANPIATI + A+ML+FLG+ +A I A++ + G KTPD+ G A+T QV Sbjct: 309 GIANPIATIRSTALMLEFLGH-----NEAAQDIYKAVDANLREGSIKTPDLGGKASTQQV 363 Query: 352 ADAICKII 359 D + + Sbjct: 364 VDDVLSRL 371 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 170/366 (46%), Gaps = 15/366 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ + GDGIG E+ + VLQAA + + ++ E H + Sbjct: 1 MSNLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEI-GFASLKKHKTTFRSE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + D + G D P R+ FD Y N+RP + G Sbjct: 60 VLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 P ID V+RENTEG YS G +V I TR+G RI F+ A Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAEIGFKYA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R RK L + K+N L S + E +++ YPE+ + +Q +D + A + P FD Sbjct: 176 MER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRDPSVFD 234 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++A+NLFGD LSD G +G+A S N + + HGSAPDI GKNIANP+ Sbjct: 235 VILATNLFGDNLSDAASEIAGGLGLAESINAGENY---CIAQAQHGSAPDIAGKNIANPV 291 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAI 355 + I + AMMLD+LG +++ ++ I AI++ I + +T D+ GN +T D + Sbjct: 292 SLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDIGGNLSTTDFTDVL 351 Query: 356 CKIILR 361 + + Sbjct: 352 ISNLKK 357 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 353 bits (905), Expect = 8e-96, Method: Composition-based stats. Identities = 128/358 (35%), Positives = 182/358 (50%), Gaps = 31/358 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +IA IPGDGIGKEV+ I VL + A E HG +P + Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDELDVDFD-----YIYGIAGDECNEEHGTPLPQET 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + DA FGA G ++K R+E + NLRPV+ +P Sbjct: 64 IDIVRDSDACLFGAAGETAA--------DVIVKIRQEMKMFANLRPVKSYPNTKSLF--- 112 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++DF +VRENTEG Y + E + I + V TR +RI+ YAF+ A+ Sbjct: 113 --ENVDFMIVRENTEGLYIAD----QEEETEDGAIAKRVITREAEERIIDYAFQYAKDNN 166 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T+ K+N L + + + + E YP+I + ++D V QP+ F VVV Sbjct: 167 RTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQVVVT 226 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NLFGDILSD G G +G+ PSAN+ + +LFEPVHGSAPDI G+ ANPIA + Sbjct: 227 TNLFGDILSDEGAGLVGGLGLIPSANIGADG---ALFEPVHGSAPDIAGQQKANPIAMML 283 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +LG D A + AAI +V++ G T D+ G+ATT +VA A+ + Sbjct: 284 SAIMMLRYLGEND-----AADKFDAAILKVLSEGKTLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 168/370 (45%), Gaps = 18/370 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMP 59 M +I +PGD +G+E+ E I+VL+A ++ R FE G +P Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGG-AAIDATGVPLP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 D+ E + DA+ GAVG P + LLK R+E Y NLRP Sbjct: 60 DEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDL 119 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P+ + DF VVRE G Y V +T V RI R A Sbjct: 120 SPIKPQFAKGTDFVVVRELVGGIYFGKRKE---DDGDGVAWDSEQYTVPEVQRITRMAAF 176 Query: 177 LAQSR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +A P + S K+N LA S + E + +P ++ Q ID V P Sbjct: 177 MALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPT 236 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 + +++ SN+FGDI+SD G++G+ PSA+L + T L+EP HGSAPD+ Sbjct: 237 HLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-P 295 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 KN NPIATI + AMML + I A+++V+ G +T D+ G+ +T +V Sbjct: 296 KNKVNPIATILSAAMML----KLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEV 351 Query: 352 ADAICKIILR 361 DA+ + + + Sbjct: 352 GDAVAEEVKK 361 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 176/370 (47%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ +PGDGIG E + E +V+ E+ C Y HG+ + D Sbjct: 1 MASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAY-DAHGQAISDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E+ D++ FGAVG P VP + LL+ R++ Y NLRP +P + Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA++R R +TS K N + + + E + +++ + D + V P++ Sbjct: 180 LARTR-RNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV++ NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + AAI V+ G +T D+ T Sbjct: 299 GIANPIAMIASLAMCLRY----SFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGT 354 Query: 349 PQVADAICKI 358 ++ DAI Sbjct: 355 TEMGDAILAK 364 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 350 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 166/360 (46%), Gaps = 30/360 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + IPGDGIG V +V++A + FE+ E +P++ Sbjct: 37 APRTVTLIPGDGIGPLVTGAVEQVMEAM----HAPVHFERYEVLGNMRK------VPEEV 86 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E + R G + P + ++ R+E D + +L PG+ Sbjct: 87 IESVKRNKVCLKGGLAT----PVGGGVSSLNMQLRKELDIFASLVNCINVPGLVT----- 137 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + ++D V+RENTEGEYS L V G VV V T+ +RI RYAFE A Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITKFCSERIARYAFEYAYLNN 193 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T+ K+N + ++ + E +A++Y I +++ +D C + V +PE+FDV+V Sbjct: 194 RKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVT 253 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD-IYGKNIANPIATI 301 NL+G+++++ G G+ P N+ E D + + ANP+A + Sbjct: 254 PNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALL 313 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + AMML L RF + + A+++VI G +T D+ G+ TT +V DA+ + Sbjct: 314 LSSAMMLRHL-----RFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 115/364 (31%), Positives = 186/364 (51%), Gaps = 12/364 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M ++ + + GDGIG EV + +R+L+ G ++ EY G+ +P Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEY-QRSGEALP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ DA+ GA+G P+ + L R Y +RP+RL+ PL Sbjct: 60 QSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPL 119 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G PG+IDF +VRE+TEG + E + TR +R+ R AFE A+ Sbjct: 120 KGHGPGEIDFVLVRESTEGLFYGRD--AIADLEADEATNLLRITRSASERVCRLAFETAR 177 Query: 180 SR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +KT+T K+N L SM Y+ + +A+ + +I+ + ++D V +P+ FD Sbjct: 178 RRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFD 236 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APS ++ + ++F+P HGSAPDI G++IANPI Sbjct: 237 VMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDD---AAVFQPSHGSAPDIAGQSIANPI 293 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICK 357 A + AMML++L + + R +V++ +T DM GN +T ++ D I + Sbjct: 294 AMHLSTAMMLEWLDHPETRRAADALNAAI--ADVLSDPTQRTADMGGNLSTVEITDKIAE 351 Query: 358 IILR 361 + + Sbjct: 352 RLSK 355 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 97/362 (26%), Positives = 161/362 (44%), Gaps = 33/362 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ GDG+G E++ + ++ A G + + +E Y + D E Sbjct: 3 KLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWET 58 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L R + + P + + R++ + N+RP + Q Sbjct: 59 LKRNKVLLKAPITTPR----GGGVRSLNVTLRKKLGLFANIRPCKS-------HLEWQDP 107 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D ++REN E YS + R T + V T +RI RYAFE A+S RK Sbjct: 108 KMDIVIIRENEEDLYSGIEYRQTLDTYN----CTKVITESTSERICRYAFEYARSNGRKK 163 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K N + ++ + + + +A YP+I + IDI AR PE+FDV+V NL Sbjct: 164 VTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNL 223 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDI+SD+ +G++G+ S N+ E ++FE VHGSAPDI ++IANP + A Sbjct: 224 YGDIISDIAAEISGSVGLGGSINIGEEY---AMFEAVHGSAPDIADQDIANPSGLLNAAM 280 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKII 359 ML ++G ++ + +A + + G T D+ T + + I I Sbjct: 281 YMLSYIGQ-----KEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 Query: 360 LR 361 R Sbjct: 336 DR 337 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 348 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 113/365 (30%), Positives = 173/365 (47%), Gaps = 14/365 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K +A + GDGIG E++P +++L AA G +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L D G + S R+ F + N+RP + F G Sbjct: 81 TLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG-----GN 135 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 D +VRENTEG Y+ G +V I + TR +RI AF+LA Sbjct: 136 AIVEGTDLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAHEAFQLA 195 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R K +T K+N L ++ + + + + YP++ + HID V + ++FD Sbjct: 196 RTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVRRADKFD 254 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G++GIAPS N + ++ + HGSAPDI G++IANPI Sbjct: 255 VIVTENMFGDILSDLAGEVAGSLGIAPSINSSATH---AMAQASHGSAPDIAGRDIANPI 311 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A I + AM+L +L DE+ +A + + AA++ +A G TPDM G ++ ADA+ Sbjct: 312 AMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDMGGTSSCSGFADAVV 371 Query: 357 KIILR 361 R Sbjct: 372 AATAR 376 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 348 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 117/381 (30%), Positives = 175/381 (45%), Gaps = 30/381 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M T +I +PGD IG E++ E I+VL + HG + Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQ 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPV-RLFPGV--PC 117 + DA+ FG++G P+ H + LL+ R+ D + NLRP L P + Sbjct: 61 SVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGAS 120 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 P+ F VVREN G Y E +V V+TR ++R+ R + + Sbjct: 121 PIREHVVKGTRFIVVRENCGGAYFGEKKE-----EEDVASDLWVYTRPEIERLARVSAAV 175 Query: 178 AQSRPRK-------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ R T+ SA K+N LA + + A+ +P+I Q D + Sbjct: 176 ARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSMAMLM 235 Query: 231 VMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGS 285 V P RF+ V+ N FGDILSD+ A TGT+G+ PSA+L ++EPVHGS Sbjct: 236 VRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGS 295 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG------PKT 339 APDI GK +ANP+A I + AMML + ++ + A+ +V+ +T Sbjct: 296 APDISGKGLANPVAQILSVAMMLRY----SMGLEKEATAVERAVVKVLDAKSEGGLEIRT 351 Query: 340 PDMKGNATTPQVADAICKIIL 360 D+ G AT QV DA+C+++ Sbjct: 352 GDLGGRATCSQVGDAVCEVLG 372 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 116/365 (31%), Positives = 180/365 (49%), Gaps = 28/365 (7%) Query: 1 MMKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M +T +I IPGDGIG E++ + VL A G ++ ++A + G + Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL----GSPFEWDS-QYAGMAAIARVGDPL 61 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P + + + G + P ++ R+EF+ + N+RP Sbjct: 62 PRETIQSIHHNKLALKGPLTT----PTGGGYRSVNVQLRKEFELFANVRPALTL------ 111 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-HEVVIQESVFTRRGVDRILRYAFEL 177 + G + ++D ++REN +G Y++ + G + H V + TR G RI+RYAFE Sbjct: 112 IPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPER 236 A RK +T K+N L + E + +A+ Y I ++++ +D + V+ P R Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLVLDPGR 231 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V +NLFGDILSDL G +G+AP N+ ++FE VHGSAPDI GK IAN Sbjct: 232 FDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIG---KQAAIFEAVHGSAPDIAGKGIAN 288 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE-EVIAHGPKTPDMKGNATTPQVADAI 355 P+A + A AMMLD +G D + AI + G +TPD+ G A T ++ A+ Sbjct: 289 PLALMLAAAMMLDHVGKTD-----LATRLRNAIRITTLEDGIRTPDLGGTAKTRELTQAL 343 Query: 356 CKIIL 360 I Sbjct: 344 ISRIG 348 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 347 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 123/367 (33%), Positives = 186/367 (50%), Gaps = 30/367 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER----WGFALSFEQMEW-ASCEYYSHHGKMMPDD 61 I IP DGIGKEV+P ++V+ AA + S + + A E + GK +P + Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKSLPVE 93 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L + D FG+V P + S ++ R+ D Y N+RP + Sbjct: 94 TVEALKNKCDGAIFGSVQSPSHKVEGYS--SPIVAMRKLVDLYANIRPCQDL-------- 143 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 ID +VRENTE Y V+ T + + + + T R RI A++LA Sbjct: 144 ---AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEIAYKLAV 200 Query: 180 SRPRK---TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 R + +T KSN L++S + E +++ YP+++ ++Q +D + + ++ P + Sbjct: 201 QRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKMILDPTQ 260 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 +DVVVA NL+GDILSD G A G +G+ SANL+ +L EPVHGSAPDI+GK I+N Sbjct: 261 YDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS---FALVEPVHGSAPDIFGKKISN 317 Query: 297 PIATIWAGAMMLDFLGNGDER---FQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVA 352 PIATI A AM+L L D + + + + A+ V+ TPD+ G T + Sbjct: 318 PIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGNTETLV 377 Query: 353 DAICKII 359 DAI K + Sbjct: 378 DAIIKNL 384 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 346 bits (888), Expect = 6e-94, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 67 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 119 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 120 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 175 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 176 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 235 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 236 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 292 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + I + I Sbjct: 293 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIR 346 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 346 bits (887), Expect = 9e-94, Method: Composition-based stats. Identities = 112/372 (30%), Positives = 177/372 (47%), Gaps = 19/372 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T ++ +PGDGIG EV+ E R++ + + E Y + D Sbjct: 1 MATHKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGG-AAYDADKVAITDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 DA+ FGAVG P VP LL+ R++ + NLRP +P + Sbjct: 60 TMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + + G + I V+ ++RI R AF+ Sbjct: 120 SLKPEVVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R R +TS K N + + + + + A Y +++ + Q D V P++ Sbjct: 180 LARKR-RNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +++EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATT 348 +ANP+A + + M L + + + + AI V+A G +T D+K +T Sbjct: 299 GLANPVAMLASFGMALRY----SLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVST 354 Query: 349 PQVADAICKIIL 360 Q+ +AI + + Sbjct: 355 SQMGEAIVQEMQ 366 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 346 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 117/371 (31%), Positives = 168/371 (45%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E I+VL+A A F Q H + D Sbjct: 1 MATHNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 + DA+ GA+G P+ + LLK R+E Y NLRP Sbjct: 61 EALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + DF VVRE T G Y E ++R + RI R A Sbjct: 121 SPLKAEVCRGTDFIVVRELTGGIYFG---DRTEDDGSGYACDTEPYSRAEIVRIARLAGF 177 Query: 177 LA-QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA P + S K+N LA S + + +++ +P+++ + Q ID V P Sbjct: 178 LALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIY 290 + VV+ SNLFGDI+SD G+IG+ PSA+L + ++EP+HGSAPDI Sbjct: 238 ALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDIS 297 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP+ TI + AMML + + + + AA++ I +G KT D+ GNATT Sbjct: 298 GKGIVNPVGTILSVAMMLRY----SLNLPKEADAVEAAVKAAIDNGTKTKDLGGNATTSD 353 Query: 351 VADAICKIILR 361 + +A+ + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 101/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 104 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 105 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 157 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 213 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 214 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 273 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 274 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 330 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + + + I Sbjct: 331 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIR 384 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 108/371 (29%), Positives = 172/371 (46%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 +K +I +PGDGIG EV+ E +V+ ++ + A Y HG + D+ Sbjct: 4 IKKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDE-DLAGGCSYDKHGTPITDE 62 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + + + GAVG P +LLK R+E + NLRP F + Sbjct: 63 VFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDAS 122 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + I +T + R+ + AF+ Sbjct: 123 TLKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFD 182 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R +TS KSN + + +E E + Y ++ D + + P++ Sbjct: 183 LARKRS-NRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQ 241 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V NLFGD+LSD TG++G+ PSA+L + +++EP+HGSAPDI GK Sbjct: 242 FDVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKE 301 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 IANPIA+I + AM L + + + A+++V+ G +T D+ K +T Sbjct: 302 IANPIASILSFAMALRY----SLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTS 357 Query: 350 QVADAICKIIL 360 + DAI + Sbjct: 358 AMGDAIISKLQ 368 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 159/359 (44%), Gaps = 26/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG+E + + A + FE+++ E + + Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDVTGMEKNNKSSGDALHEAI 75 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P H S + R+E D Y +L ++ PG + Sbjct: 76 QSLKRNKVGLKGILFTPFEKGGHTSF---NVALRKELDIYASLVLIKNIPGFKT-----R 127 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++DF ++RENTEGEYS L + G VV + T RI ++AF+ A R Sbjct: 128 HDNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKIITEYKSKRIAQFAFDFALQNGR 183 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K++T K+N + ++ + +A Y I +D + V +P++FDV+V Sbjct: 184 KSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G ILS++G A G G+ P AN + +LFEP I G+ ANP A I Sbjct: 244 NLYGSILSNIGSALVGGPGVIPGANFGRDY---ALFEPGCRHVGLSITGRGEANPTAAIL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + +ML LG + + I AA VI G T D+ G+A+T AI + + Sbjct: 301 SACLMLRHLG-----LKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 343 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 148/362 (40%), Positives = 203/362 (56%), Gaps = 14/362 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M +T+ +A +PGDGIG EV+ E +RVL+ A +L Q + ++ G+++ D Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVP-ADVSLDTTQYPF-GAGHFLETGQILTD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVP---DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 L++ DAI GAVG I G LLK R FD Y+NLRP L PGV Sbjct: 59 SDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVAS 118 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PLA PG +DF VVRE TEG Y+ GG + GTEHE+ + SV T GV+R +R+AFEL Sbjct: 119 PLAA--PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAFEL 176 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R RK +T K+N L + W V+ +A +P++ D H+D V P RF Sbjct: 177 AEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPSRF 236 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V+ NLFGDI++DL A +G IG+A S N+NP FPS+FEPVHGSAPDI G+ A+P Sbjct: 237 DVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADP 296 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 A I + A++LD LG + + + T D +T +V DAI + Sbjct: 297 TAAILSVALLLDHLGLSEAAARVSAAVSDDLAARA------TGD-AAPRSTAEVGDAILR 349 Query: 358 II 359 + Sbjct: 350 AL 351 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 96/358 (26%), Positives = 167/358 (46%), Gaps = 25/358 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK-MMPDDWHE 64 + IPGDGIG E++ + + G + FE++ + + ++ Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFRHI----GVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + R G + P L+ R D + N+ + PG+ + Sbjct: 108 SIKRNGVAMKGNIFTPLDAIPG--FRSLNLELRVHLDLFANIVRCKSIPGIQT-----RH 160 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ++D ++R+NTEGEYS L G V+ V T +I +YAF+ A+ RK Sbjct: 161 NNVDLVIIRQNTEGEYSHLEHENVSG----VIENLKVTTEEACMKIAQYAFDFAEKHDRK 216 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K+N + + + E M+ +YP I ++ ID C + V P++FDV+V N Sbjct: 217 KVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLPN 276 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIWA 303 L+G+I+S++G + G GI P N+ + ++FE + DI GK+I+NPI+ ++A Sbjct: 277 LYGNIVSNIGASLVGGPGIVPGENIGGDY---AIFESGSRHTGLDIQGKDISNPISMLFA 333 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 +ML+ L F + I +AI +V+ G T D+ G+ TT Q A+ + + Sbjct: 334 STLMLEHL-----EFTAYADLINSAILKVVQRGVLTADVGGSHTTTQFLSALKSELDQ 386 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 109/370 (29%), Positives = 173/370 (46%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG E + E +++ E ++ C Y HG + + Sbjct: 1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAY-DAHGAAISEA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC-- 117 ++ DA+ FGAVG P VP + LL+ R++ + NLRP +P + Sbjct: 60 DMQKALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 +A++R + S K N + + + E Y +++ + D + V QP++ Sbjct: 180 MARTRQ-NRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + + AI V+ G +T D+ T Sbjct: 299 GIANPIAMIASFAMCLRY----SFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGT 354 Query: 349 PQVADAICKI 358 ++ +AI Sbjct: 355 VEMGEAILAE 364 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 340 bits (873), Expect = 4e-92, Method: Composition-based stats. Identities = 126/350 (36%), Positives = 171/350 (48%), Gaps = 15/350 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + R+ +PGDGIG EV+ RV AAA R+G L +E+ G + Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRI-GAAAIREEGAPVSK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + + DA+ GAVG P+ + LL RRE + NLRPV P + P Sbjct: 60 ETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D +VRE T G Y E SV+TR V+R+ R AFE A Sbjct: 120 LRPGVAEGVDLLIVRELTGGAYFGEKEE-----GEERASDLSVYTRGEVERVARVAFEAA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R + S K+N LA S W V +A +YP++ + +D V P RFD Sbjct: 175 RGR-RGRVASVDKANVLATSR-LWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRFD 232 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ NLFGDILSD G++G+ PSA+L + P +FEPVHGSAPDI GK +ANP Sbjct: 233 VILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGS-PGIFEPVHGSAPDIAGKGVANPY 291 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 A I + AMM +A I +E +A G TPD+ G++ T Sbjct: 292 AAILSAAMMFRH----GLGRPEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 109/372 (29%), Positives = 177/372 (47%), Gaps = 18/372 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ +PGDGIG EV+ + R++ + + Y HG P + Sbjct: 1 MAAKKLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGG-AAYDVHGTPYPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E DA+ GAVG P P LL R++ + NLRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y ++ V+T + RI R AF+ Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R K L S K+N L ++ + +E ++ E +P++ ++D + V P++ Sbjct: 180 LARKRN-KKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V N+FGDILSD TG++G+ PSA+L + +L+EPVHGSAPDI GK+ Sbjct: 239 FDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKD 298 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 +ANP+ATI + AM L + + I A++ V+ G +T D+ K +T Sbjct: 299 MANPLATIMSFAMCLRY----SFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTT 354 Query: 350 QVADAICKIILR 361 + +A+ + + + Sbjct: 355 VMGEAVVRELDK 366 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 121/364 (33%), Positives = 182/364 (50%), Gaps = 27/364 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + ++ +PGDGIG EV+ + +L+A AE G +++ Y H + P+D Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHI--------SLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + D I GAVGWP + +++ R + D Y N+RPV+L PGV Sbjct: 69 ARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGV 128 Query: 116 PCPLAG-----KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRI 170 ++G +P +D ++RENTEG Y+ +GG++ G V + TRRG +RI Sbjct: 129 AHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCERI 188 Query: 171 LRYAFELAQSRPR-------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHI 223 +R AFEL + R R K +T K N L + E +A YP+I + + Sbjct: 189 IRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVASEYPDIANELAIV 247 Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D V QPE +DV V +NLFGDI++DL G +G+A N+ E ++FEP+H Sbjct: 248 DAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEH---AMFEPIH 304 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTP 340 GSAP + GK+ ANP+A + A L +LG D R + + + A+ V G P T Sbjct: 305 GSAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTV 364 Query: 341 DMKG 344 D+ G Sbjct: 365 DLVG 368 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 177/366 (48%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IA + GDGIG E+ +G+ V+ A E++G +++E + G P++ + Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYE-YAICGADAIDKVGDPFPEETYR 61 Query: 65 QLSRFDAIYFGAVGWPDTVPD---HISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPL 119 DA+ F AVG P D + LL R++ + N+RPV+ F + PL Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + DF +RE T G Y + +++ +++TR ++RIL+ FE A Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQ-----DNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RK LT K+N LA S W + + MA YPE+ D +D + + +P+ FDV Sbjct: 177 KR-RKHLTVVDKANVLASSR-LWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDV 234 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N FGDIL+D G +G++G+ PSA+ +FEP+HGS P G NIANP+A Sbjct: 235 MVTENTFGDILTDEGSVISGSMGLLPSASTGES---TPVFEPIHGSWPQAKGLNIANPLA 291 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADAI 355 I + AM+ ++ + I A++ + +TP++ T +V I Sbjct: 292 QILSVAMLFEYF-----DCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWI 346 Query: 356 CKIILR 361 I + Sbjct: 347 VDYIRK 352 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 339 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 103/363 (28%), Positives = 168/363 (46%), Gaps = 30/363 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDG+G E++ + +L+ A +S E ++ +Y + Sbjct: 7 SVPITVAYGDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAPSAW 62 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E +SR + P + R+ YVN+RP + P+ G + Sbjct: 63 ESISRTRLLLKAPTMTPQ----GSGHKSLNVALRQRLGLYVNVRPCVSY----FPVVGTK 114 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 D+D ++REN E YS + +++E T V + TR ++I YAF A++ R Sbjct: 115 HPDLDVVIIRENEEDTYSGVEHKLSEDTHECV----KISTRSASEKICAYAFNYARAHNR 170 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T K N + ++ + +A+ YP+I + +D+ A+ PE FDVVV + Sbjct: 171 KKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVVVTT 230 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SD+ +G+IG+ SAN+ ++FE VHGSAPDI GKN+ANP + A Sbjct: 231 NLYGDIVSDIVSLSSGSIGLTGSANIGDYY---AMFEAVHGSAPDIAGKNVANPSGLLNA 287 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK------GNATTPQVADAICK 357 ML +G D+ I A + + G T D+ A+T + A AI Sbjct: 288 AVQMLVHIGQLDK-----AGVIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIVG 342 Query: 358 IIL 360 + Sbjct: 343 NLG 345 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 120/346 (34%), Positives = 177/346 (51%), Gaps = 9/346 (2%) Query: 17 KEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL-SRFDAIYFG 75 V+ E +L+ ER G + +++ + Y G P+ + A+ G Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDL-GADRYLRDGTTFPNQIQIAIQRECSAVLLG 77 Query: 76 AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVREN 135 A+G P VP+ L R +D Y N+RPVR PL G+ DIDF V REN Sbjct: 78 ALGDPR-VPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFREN 136 Query: 136 TEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 TEG Y +GG+ GT EV I E V TR+GV+RI+R AF+ A++ R +T A KSN + Sbjct: 137 TEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMADKSNAM 196 Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 + W + YPEI+ + ++D LC + P +F V+V +NLFGDI++DLG Sbjct: 197 RHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGA 256 Query: 256 ACTGTIGIAPSANLNP-ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNG 314 A G +G+A SAN++ + +LFEPVHGSAP + GK+IANP A + ++L LG Sbjct: 257 ALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLG-- 314 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + I + + + G T D+ G T + + I Sbjct: 315 ---WPEEERRIERWVSQALDQGMCTVDVGGTLGTRAAGAWVREQIA 357 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 97/359 (27%), Positives = 160/359 (44%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +A + GDG+G E+L V Q G + FE++ D Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEV-----AVNQESEDATFTDAL 118 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + R + Y ++ R FPGV + Sbjct: 119 LAMKRNGVGIKGNFAT------EPGQSSRNVALRLNLNLYAFVQRCRNFPGVVT-----R 167 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS L G VV + TR RI ++AF+ A R Sbjct: 168 HQNVDIVIIRENTEGEYSRLEHENVPG----VVESLKIITREKSTRIAQFAFDYAVRHNR 223 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + ++A+NYP+I ++ ID C + V +P++FDV+V Sbjct: 224 KKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFDVIVLP 283 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ NL P+ +LFE S + GKNIANP + Sbjct: 284 NLYGNIVGNVAAGLVGGAGLTTGINLGPQ---NALFEMGTRNSGRSLAGKNIANPCGMLL 340 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A ML++LG+ + I ++ +VI +T D+ G+ T +V +A+ K + Sbjct: 341 TSADMLEYLGHI-----KEAKLIRDSVVDVIGEQKIRTADLGGSFKTSKVIEAVLKSLR 394 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 338 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 138/367 (37%), Positives = 190/367 (51%), Gaps = 19/367 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA +PGDGIG EV +RVL A F + F + A E + G P+ Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALG-TSFPIEFRDYD-AGAECFRRTGTAFPEATQV 70 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGS--LLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A+ GA G PD + + G +K R D Y N+RP+RL G P L GK Sbjct: 71 ACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ--- 179 P DI F +VRENTEG Y++ GG ++ V TR GV+RI+RYA ELA+ Sbjct: 131 GPDDIRFTIVRENTEGLYAARGG--GNIIRGQIATDTLVMTREGVERIVRYAAELARDGQ 188 Query: 180 ---SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 + + +T K+N L S ++ E + + + P I + +D + + +PE Sbjct: 189 GAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERPEH 247 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V NLFGDILSDLG A G +G+APS + + + F+ HGSAP I GK +AN Sbjct: 248 FDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRDHGY---FQGSHGSAPTIAGKGLAN 304 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 PIA I +GAMMLD+LG + D +A I A V+ G TPD+ G+ +T A Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCAA 364 Query: 354 AICKIIL 360 IC + Sbjct: 365 EICATLG 371 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 109/382 (28%), Positives = 168/382 (43%), Gaps = 27/382 (7%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMM 58 M K T +I +PGDGIG EV+ E RVL+ A + E ++ C HG+ + Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCS-IDKHGEPL 59 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVP-DHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 E DAI GA+G P + +LL R+ Y N+RP Sbjct: 60 TAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLL 119 Query: 117 --CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL +D V+RE G Y + + + +++ V RI R Sbjct: 120 AYSPLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSR 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 ++A P + S K+N LA S + E + +P+++ D +D V P Sbjct: 180 RQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANP 239 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP----------SLFEPVH 283 ++ + V++ NLFGDILSD G++G+ PSA+L +P ++EP+H Sbjct: 240 KKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIH 299 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV-----IAHGPK 338 GSAPDI G+ IANPI TI + AM L ++ I AA+E G + Sbjct: 300 GSAPDIAGQGIANPIGTILSAAM----LCGTRSVWRSPAKAIEAAVEGARRQGDRREGLR 355 Query: 339 TPDMKGNATTPQVADAICKIIL 360 T D+ G++ T + + +I+ Sbjct: 356 TADLGGSSKTKDIGHKVVEILK 377 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 103/359 (28%), Positives = 166/359 (46%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+ VL + G + FE ++ + D Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVLH----KCGAPIDFEVIDI--------KDESSTDAAI 134 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 L R G + + P + RR+ D Y N+ P + PGV + Sbjct: 135 ISLKRNGIGLKGTITTNISNPQS---QSINAQIRRKLDLYSNIVPCKSIPGV-----WTR 186 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G +D V+RENTEGEY SL +G VV + T + RI ++AF+ A R Sbjct: 187 HGQVDLVVIRENTEGEYGSLEHENVDG----VVESLKIITEKKSRRIAKFAFDYALQNNR 242 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 + +T+ K+N + ++ + E ++++Y +I ++ ID C + V P++FDV+V Sbjct: 243 RKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFDVMVMP 302 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+S +G G IG+ P N+ + ++FE D+ G N ANP ++ Sbjct: 303 NLYGNIVSHIGIGLVGGIGLVPGKNIGDKY---AIFESGARNIGSDLVGLNRANPCGFLF 359 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A+ML LG + I +A+ I +G +TPD++G+ TT DA+ K I Sbjct: 360 TSALMLRHLG-----LDDYADIIESAVRTTIKNGKCRTPDIQGDRTTADFIDAVIKEID 413 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 336 bits (861), Expect = 9e-91, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 175/366 (47%), Gaps = 16/366 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA +PGDGIG E++ + VL+ ER G +Y G D+ Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAFSDENM 65 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + DA+ GA+G P + + L R E D Y LRP+R +P +P L K+ Sbjct: 66 AACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDKR 125 Query: 124 PGDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID +VRE TEG YS G + + V + + +R G R+ +AF +A+ R Sbjct: 126 ASQIDLVLVREQTEGILYSRCRGTIE---DDRVAWETMMISRNGTSRVSEFAFRVAERRA 182 Query: 183 R-----KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + + +SN L SM ++ +AE +P + D ++D + V P F Sbjct: 183 KSRRRPGKVLCVDRSNAL-TSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKSPWEF 241 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V N FG ILSDL G++G+APSA++ + ++F+P HGSAP I G+ +ANP Sbjct: 242 DVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEKH---AVFQPAHGSAPHIAGQGLANP 298 Query: 298 IATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 +A I + A+MLD+L +G+ R + A+E+ + + G T + AI Sbjct: 299 VAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALTV-VCPVEFGGKDGTAAITKAI 357 Query: 356 CKIILR 361 I + Sbjct: 358 IAQIRK 363 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 334 bits (856), Expect = 4e-90, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 159/359 (44%), Gaps = 32/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDG+GKE+ + +A + +E + ++ + Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINIKQTDHKEGV-----YEAV 78 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E L R G P D + R++ D Y N+ + GV + Sbjct: 79 ESLKRNKIGLKGLWHTPA---DQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI---- 131 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID V+RENTEGE+S L G VV V TR +RI R+AF+ A+ R Sbjct: 132 -PDIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRPKTERIARFAFDFAKKYNR 186 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K++T+ K+N + + + + + + YP+I +D + V +P +FDV+V Sbjct: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +++G IL ++G A G G+ AN + ++FEP DI G+N+ANP A I Sbjct: 247 PSMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEPGSRHVGLDIKGQNVANPTAMI 303 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + +ML+ LG + I A+ E IA G T D+ G+++T + I + Sbjct: 304 LSSTLMLNHLG-----LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 175/374 (46%), Gaps = 20/374 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +I + GDGIG EV+ + RV+ + A E Y G + D Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGG-AAYDAQGTPLHD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 D DA+ GAVG P P + LL+ R++ + + NLRP +F + Sbjct: 60 DTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAE 119 Query: 117 -CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYA 174 L + +D +VRE T G Y ++ + V+ + R+ + A Sbjct: 120 ASTLKTELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKVA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LA R K L S K+N + S W E V + +YPEI + D + V QP Sbjct: 180 FDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 ++FDV+V NLFGDILSD TG++G+ PSA+L +++EPVHGSAPDI G Sbjct: 238 KQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM---KGNA-T 347 ++ ANP+ATI + +MML + + + + A+ V+A G +T D+ Sbjct: 298 QDKANPLATILSFSMMLRY----SFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVG 353 Query: 348 TPQVADAICKIILR 361 T + DA+ + + Sbjct: 354 TTGMGDALLAEMAQ 367 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 112/356 (31%), Positives = 171/356 (48%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRIA I GDG+G E++ + +L+ F +++ A Y+ GK + D+ E Sbjct: 1 MRIAVIKGDGVGPEIMGATLSLLE-----RYIGADFIEIK-AGKSYFIEEGKPIEDNAIE 54 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D++ G V P P S RREF Y N+RP R + G+ Sbjct: 55 KIRECDSLLKGPVATPTKGP---SYPSVNTLLRREFKLYANVRPFRSYEGIS-------I 104 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID +VREN E Y + + I V T+RG +RI +AF LA+ R Sbjct: 105 RRIDTILVRENLECLYYGWEVE-----DEDRAIAMRVITKRGAERISEFAFNLAKREGRG 159 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K N L + + + +A + ++R D + +D + V FDV++ N Sbjct: 160 RVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVMLTPN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSD+ G+IG+ SA + + + FEP+HG+ DI GK +ANPI I A Sbjct: 219 LYGDILSDVAAGVVGSIGLCGSAQIGED---FAAFEPIHGTGEDIAGKGVANPIGMIIAA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +MMLD+L R + I A++ VI TPD+ G+ T QV + I + Sbjct: 276 SMMLDWLWERG-RSPKRGEKIREAVDSVIRDRILTPDLGGDFRTEQVVEKIVDRLR 330 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 126/356 (35%), Positives = 173/356 (48%), Gaps = 15/356 (4%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA IPGDGIG EV+ + VL A G + ++ + + Y G+ + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDAL----GLGTRTDILDHVNADTYLRTGEALTGSDLDR 76 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + +A GAVG P + D + G L R E D YVN RP RL+ PL Sbjct: 77 IRSSEAALLGAVGDPR-LGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARR 135 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ID +VRENTEG YS +GG GT E+ + + TR GV R+L +AF A R++ Sbjct: 136 AIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA----RRS 191 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N + W +P I ++D R P FDV+V +N Sbjct: 192 VCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNS 251 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL A G +G+A SANLNP T +LFEPVHGSAPDI G ANP I + A Sbjct: 252 YGDILSDLTAALAGGLGVAASANLNP-VTGRALFEPVHGSAPDIAGSGTANPFGAILSVA 310 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 ++ + LG +E +A G TPD+ G T +V A+ + R Sbjct: 311 LLAEHLGRNEEADAVRRAV-----AAAVAAGRVTPDLGGPLGTKEVGAAVLAELRR 361 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 173/355 (48%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RIA IPGDG+G E++ I VL+ ++ L E A E G +P++ Sbjct: 3 RIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFE-AGDETKRKRGVALPEETLNG 61 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA A+G S +L R++ D YVNLRP + +P + Sbjct: 62 VMNSDATLMVAIG--------ESAREVILPLRQKLDLYVNLRPAKSYP------VPRAIP 107 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D +VRENTE Y G R + + + TRR +RI R+ + A+ R + Sbjct: 108 GFDLTIVRENTEDLYVMSGWR-----GLDTAVDLRIITRRASERICRFGYRYARERGKSR 162 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N L M + E +AE + + ++D R M FDV++ +N+ Sbjct: 163 VYVVHKANVLGGCM-LFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVIITTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSDL A G +G+ PSAN+ R ++FEPVHG+AP+I GKNIANP+ATI + A Sbjct: 220 FGDILSDLAAAFIGGLGMYPSANIGESR---AIFEPVHGTAPEIAGKNIANPMATILSAA 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MM+ +LG+ I A+ G TPD+ G+ T +V I +I+ Sbjct: 277 MMMGWLGHEGG-----SKLIEEAVRRACELGYTTPDVGGSMRTKEVGLKISEIMR 326 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 119/361 (32%), Positives = 174/361 (48%), Gaps = 17/361 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I + GD IG E++PE +RV+QAAA R G A+ ++ + G +PD E Sbjct: 1 MKIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPI-GRAALDSLGSTLPDGTIE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L D G +G P R+ FD + N+RPV+ +PC Sbjct: 60 RLDALDGWLLGPIGH-MAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL-----H 113 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D +VREN EG G +V I V TR G ++ R AFELA++R Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFELARAR 173 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ LT+ K + + E +A YP++ +D+ +D R VM P+R+DVVV Sbjct: 174 -RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYDVVV 232 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDIL+D G +G+A P ++ + HGSAPDI G+ IANP A I Sbjct: 233 TTNMFGDILTDEAAGLVGGLGMAAGLCAGPRH---AMAQATHGSAPDIAGRGIANPYAMI 289 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKI 358 +G M+LD+LG A I A+ +I TPD+ G TT + AI + Sbjct: 290 MSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQGTTAGMGSAIIEA 349 Query: 359 I 359 + Sbjct: 350 M 350 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 329 bits (845), Expect = 6e-89, Method: Composition-based stats. Identities = 108/381 (28%), Positives = 163/381 (42%), Gaps = 36/381 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+T + +PGDG G E++ VL AA GF + ++ + A + ++PD Sbjct: 1 MRTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWD-VHQAGQRALAESESLLPDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + A G P + R+E D Y LRPVR P + Sbjct: 60 TLNSIRTNGAALKGPTTTPI----GTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEE 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLG---------------GRVNEGTEHEVVIQESVFTRRG 166 + +D VVRENTE Y+ L G + + + FT G Sbjct: 115 PERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPFTPHG 174 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +R++ +AF A RK + S + + + +A +P I + L Sbjct: 175 CERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVPVPAL 234 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 CA V P R DV+V NL+GDI+SD+ A G++G+AP AN+ ++FE HGSA Sbjct: 235 CADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAHH---AVFEATHGSA 291 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDM--- 342 P+ G NP A I++G M+LD LG + I AA+E+V+A G T D+ Sbjct: 292 PEFAGSGRLNPTALIFSGCMLLDHLGE-----HETAARIRAAVEDVVAAGEVLTFDLLAP 346 Query: 343 ---KGNATTPQVADAICKIIL 360 ATT + A+ + Sbjct: 347 QRSADAATTVEFTRAVTDRLG 367 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 165/366 (45%), Gaps = 31/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI + G+GIG E+ IRV++A G ++ + A E +G +P + Sbjct: 1 MRIGVLKGNGIGPEITAATIRVIEA----TGIQPEWDFIPIA-DEAVRLYGHALPPQVIQ 55 Query: 65 QLSRFDAIYF---------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 ++ G + T ++ RRE + +VN RP+R + G+ Sbjct: 56 RIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGI 115 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +D ++RE TE Y + +G TR ++ +YAF Sbjct: 116 SG-----RHEKMDMVIMREITEDTYIGWEKPLEDGA---AAEAIKRVTRSASWKVSQYAF 167 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+ RK ++ K+N L + + + +A YP+I D ID C V P Sbjct: 168 EYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPC 227 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDVVV N +GDI SDL G++G+AP AN+ S FE HG+APDI G A Sbjct: 228 WFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDS---ASTFEAAHGAAPDIAGTGAA 284 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADA 354 NPIA I +GA +L G G + I A+ VI G TPD+ G +TT QVADA Sbjct: 285 NPIALILSGAELLAHAGYG-----KGSEAIREAVTRVIEAGRTLTPDLGGRSTTEQVADA 339 Query: 355 ICKIIL 360 I + Sbjct: 340 ISVEVR 345 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 108/362 (29%), Positives = 175/362 (48%), Gaps = 13/362 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI +P DGIG E++ + VL++A + L+F+ + +G + D+ Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDV-GFTSLEKYGTTLRDEVLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + +D + G D FR D Y N+RP R P + + + Sbjct: 60 KAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRT 119 Query: 125 GDIDFYVVRENTEGEY---SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D ++RE TEG Y + G ++ I TR +RI R AFELA R Sbjct: 120 --MDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR 177 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 +K +T+ K+N ++ + E V +A ++PE+R D ID A V PERFDV+V Sbjct: 178 -KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 A+N +GDI+SDL +G++G+A S + + HGSAPDI G++ ANP++ I Sbjct: 237 ATNFYGDIISDLASELSGSLGLAGSMMASDTH---CCAQAQHGSAPDIAGQDKANPVSMI 293 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + AM++ ++G + A + AA++ V+ + +TPD+ GN + K+ Sbjct: 294 LSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKV 353 Query: 359 IL 360 I Sbjct: 354 IQ 355 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 106/369 (28%), Positives = 165/369 (44%), Gaps = 34/369 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG+E++ ++A G + +EQM+ E + G + D Sbjct: 32 QAHTVLTFDGDGIGREIVSAAKECIEA----TGVNIRWEQMD-MGYEAMQNTGVYIDDSH 86 Query: 63 HEQLSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 + ++ G + P FR+ F + N+RPVR PGV Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P D+D V+RENTE Y+ V+ T H V +R +R+ ++F+ Sbjct: 147 APF-----NDVDLVVIRENTEDVYTGEETWVDADTVHCV----KRISRGASERVADFSFK 197 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEA--MAENYPEIRWDKQHIDILCARFVMQP 234 A+ RK +T+ K+N S + A + I D Q D + +++P Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLMIEP 257 Query: 235 ERFDVVVASNLFGDILSDLGP----ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 + FDV+ NL+GD+++ L G++G+ PS N+ T +LFEP HGSAPDI Sbjct: 258 KSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG---THQALFEPAHGSAPDIA 314 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK IANP + I +G MML LG +A + A+ + A G D G A T + Sbjct: 315 GKGIANPTSQILSGCMMLSHLGEF-----EASQRLENALRAMYASGIVPVDFGGQADTKE 369 Query: 351 VADAICKII 359 V A+ K + Sbjct: 370 VVAAVLKHL 378 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 95/360 (26%), Positives = 160/360 (44%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PGDGIG E+L ++ A + FE+ + S D+ Sbjct: 44 RHTVTLLPGDGIGPEMLDIVQKIFTFA----NVPVDFEECQLDSKPTSPESDL---DNAI 96 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + D ++ RR D + N+ P +P + Sbjct: 97 MSIQRNGVAIKGNIET---KYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPT-----R 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 I+ ++RENTEGEYS G VV + TR ++RI R+AF+ A + R Sbjct: 149 HKGINIVMIRENTEGEYSGHEHETVNG----VVESLKICTREKLERISRFAFDYAIAHNR 204 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K +T+ K+N ++ + + V +A + YP I +D +D + V +P++FD+++ Sbjct: 205 KKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQFDIMLM 264 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATI 301 NL+G+I+S++ G G+ N+ + ++FE + I G++IANP A I Sbjct: 265 PNLYGNIISNIACGLVGGPGLVSGMNIGDKY---AVFETGTRNTGSGIAGQDIANPTAFI 321 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 AG ML +LG + N I A+ + I T D+ G A T V +A+ + I Sbjct: 322 RAGVDMLHYLG-----LTEYANLISDALFDAIVIKRLHTKDIGGTAKTSDVVNAVMRNIE 376 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 326 bits (836), Expect = 8e-88, Method: Composition-based stats. Identities = 97/357 (27%), Positives = 159/357 (44%), Gaps = 36/357 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPG GIG E+ V +A + F+ ++ + E DD Q Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL----HVPIKFDVLDNFNFEN---------DDSKSQ 80 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L + + I G + + KF + D Y N+ G+ ++ Sbjct: 81 LRKNECILLGVMTEKNQKYTD------NYKFYKYLDLYSNITFAFSVEGIT-----QRHN 129 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 + D V+RENTEGEYS + V G VV V T++ RI YAFE A R+ Sbjct: 130 NTDIVVIRENTEGEYSGVEHEVYPG----VVESIKVTTKQASLRIAEYAFEFAHLSGRRK 185 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A+ Y I++++ ID C + V P +FDV+V NL Sbjct: 186 VTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVMVMPNL 245 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +G I+ ++ TG +G+A A++ + S + + DI GKN+ NP A + + Sbjct: 246 YGSIVQNVVAGITGGVGMAAGASIGKDHALFS--QGCRHTGRDIAGKNVVNPSAMLVSST 303 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 ++L LG + I A++ I KT D+ GNATT Q + + + R Sbjct: 304 LLLRHLG-----LPNFADQICRAVQHTIQDKKIKTKDIGGNATTDQFTSEVIRSLGR 355 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 108/406 (26%), Positives = 168/406 (41%), Gaps = 66/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM--MPDDWHE 64 I I GDGIGK+V P +VL+AAAE G +S+ ++ +A +G+ +PD+ + Sbjct: 33 IPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRV-YAGESAREEYGEDVNLPDETVD 91 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G + P + R+ D Y N+RP GVP P+ P Sbjct: 92 AIREHRVAIKGPLTT----PVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPMKA--P 145 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTRR 165 ++D RENTE Y+ + +V I T + Sbjct: 146 EEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPITEK 205 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE--------- 215 G R++R A + A R +T K N + + + + +A E YP+ Sbjct: 206 GSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVFAAPDS 265 Query: 216 --------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTI 261 + +++ D + ++ + FD++ NL GD LSD A G + Sbjct: 266 LWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLSDAAGAQIGGL 325 Query: 262 GIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQA 321 GIAP N L EPVHGSAP G+++ANP A I +G +M D+LG + A Sbjct: 326 GIAPGGNFG---KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDYLG-----WDDA 377 Query: 322 HNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + I A+EE I+ G T D++ T + D I I + Sbjct: 378 ADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 95/361 (26%), Positives = 161/361 (44%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP-DDW 62 + +PG GIG E++ R ++A + FE + ++ G D Sbjct: 47 RFFVTLLPGHGIGPEMM----RHVEAIFACGKVPVDFETIIV-----DANVGDASSMDHA 97 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + R G + +++ L R + + YVN+ R PG+ Sbjct: 98 IKSIRRNGVALKGNIETTSY---SMTVEPRNLLLRNKLELYVNVVHCRNHPGI-----NT 149 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + +D V+R+NTEGEYS L V G VV + T +I +Y FE A++ Sbjct: 150 KHKGVDIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYCFEYARTHM 205 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T K+N + ++ + + +A+ YP+I + ID C + V P +FDV++ Sbjct: 206 RKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDVMLV 265 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATI 301 NL+G+I+ ++ G G+ N E ++FE + + GKN+ANP+AT+ Sbjct: 266 PNLYGNIVVNVACGLVGGAGVTSGRNYGKEY---AVFETATRNTGTPLVGKNLANPVATL 322 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 +A ML L I AIE+ + T D+ G+ATT +V + I K + Sbjct: 323 YAAVDMLKHL-----ELWDHAVVIRRAIEKTVNRDKVHTKDLGGDATTSKVVENILKEVQ 377 Query: 361 R 361 + Sbjct: 378 K 378 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 130/384 (33%), Positives = 190/384 (49%), Gaps = 42/384 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ RI IPGDGIG EV + ++V++AA +GF+L + E+Y +++PD Sbjct: 1 MKSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPY-GAEHYLSTRQVLPDH 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E++ DA+ GA+G P P I G LLK R FDQY N+RPVR F P PL Sbjct: 60 ALEEMEGLDALLLGAIGDPRVQP-GILERGILLKLRFHFDQYANIRPVRSF--TPGPL-- 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG----------RVNEGT-------------EHEVVIQ 158 G ++ V+RENTE Y +G V G +Q Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T G R +YAF+LA + +T ATKSN + ++ +A Y + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++D LC + V P F V++ N+FGDI+SDL G +G+APS N+ S+ Sbjct: 232 RVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDR---LSM 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 FEPVHGSAPDI G++ ANP+A+I +GAM+L LG A + A++ ++ Sbjct: 289 FEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETS-----AAKAMEDAVQRYLSGPVE 343 Query: 338 -KTPDMKGNATTPQVADAICKIIL 360 +M G T DA+ + + Sbjct: 344 ELPIEMGGRLGTRGAGDAVVRRLE 367 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 153/353 (43%), Positives = 203/353 (57%), Gaps = 17/353 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A IPGDGIG EV+ EG++VL+A A + + + G+++PD + Sbjct: 1 MRLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDL-GASRWQRTGELLPDTVLD 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L R DAI GA+G P VP I G LL+ R E D +VNLRP RLF GV PLA P Sbjct: 56 ELRRHDAILLGAIGDPS-VPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAA--P 112 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 G ID VRE TEG Y GG + T HEV + S+ T GV+R++RYAFE A +RPR+ Sbjct: 113 GAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALARPRR 172 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT K+N L + W VE ++ +PE+ QH+D FV P RFDV+V N Sbjct: 173 HLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVIVTDN 232 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDI++DL A TG IG+A S NL+ T PS+FEPVHGSAPDI GK +A+P AT+ + Sbjct: 233 LFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSV 292 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 ++LD LG D+ + AA+ ++ T D + T V D + Sbjct: 293 GLLLDHLGRADQ-----ARKVNAAVAFDLS----TRDPEAQVRTEDVGDRLAA 336 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 119/408 (29%), Positives = 179/408 (43%), Gaps = 62/408 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG +VLP+ IRVL+A GF ++ + E + + G +PD Sbjct: 1 MARPTVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADI-GWECWCNEGNALPDR 55 Query: 62 WHEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 + L + FGA+ P+ +S + ++ R+ F+ V +RP Sbjct: 56 TIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCL 115 Query: 111 LFPGVP------CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT------------- 151 FPG P G + +D V R+NTEG Y+ + Sbjct: 116 SFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAA 175 Query: 152 -----EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 E+ + + T++ RI AF+ A+ K +T K N L + +E Sbjct: 176 FANTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVA 235 Query: 207 EAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 + + + YPEI +ID PE + V+VASNLFGD++SD G +G A S Sbjct: 236 KQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAAS 295 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKN--IANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 N+ E ++FEP HGSAP N I NPIA I + AMMLD +G ++ + Sbjct: 296 GNIGDE---VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHIGESEK-----ADR 347 Query: 325 ILAAIEEVIAHGP-KTPDM-----------KGNATTPQVADAICKIIL 360 I AI +V+ G +T DM +G A T Q+ DAI + Sbjct: 348 IRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVE 395 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 323 bits (828), Expect = 7e-87, Method: Composition-based stats. Identities = 113/360 (31%), Positives = 174/360 (48%), Gaps = 15/360 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I +PGDGIG E++ +RVL+AA++R+ L + A HG + E Sbjct: 1 MKIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIG-HDIAGHASLQRHGATVTPALLE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D + G + D + FR+E D Y N+RP R FPG+ + Sbjct: 60 KVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAH-----RV 114 Query: 125 GDIDFYVVRENTEGEYSS---LGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G+ + VVRENTEG Y+ G + VI TR +RI R AF+LA++R Sbjct: 115 GEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDLARTR 174 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R ++ K+N L I + + +A +P++R D +D + A V P+RFDV+V Sbjct: 175 AR-HVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFDVIV 233 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDILSDL +G++G+ S N + ++ + VHGSAPDI G+NIANP + I Sbjct: 234 TTNMFGDILSDLTAELSGSLGLGGSLNAGKDH---AMGQAVHGSAPDIAGRNIANPYSLI 290 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + +L + G F A I + T D G T + + + + Sbjct: 291 LSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRDAGGELGTAEAGQSFVRRL 350 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 93/359 (25%), Positives = 161/359 (44%), Gaps = 29/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ IP DGIG+ ++ + V Q G + FE+ +D Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKSF--NDIK 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G I + R + D Y N+ + +P V + Sbjct: 99 TSVLRNGTALKGNWATSM----GIDSKSYNVLLRHDLDLYANVVKFKSYPTVIT-----R 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D V+RENTEGEY++L G V+ + T++ +RI +YAF+ A R Sbjct: 150 HNNVDLIVIRENTEGEYTNLEHENIPG----VIEMIKIITKKKSERIAKYAFDYAMENNR 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + + + +AE YPEI ++ ID + V +PE+FDV+V Sbjct: 206 KKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFDVIVTP 265 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G++LS++ A G G+ N +FE S DI KNIANP++ ++ Sbjct: 266 NLYGNVLSNIAAALVGGPGLPHGENHG---NGIHVFESGTRNSGMDIATKNIANPMSMLF 322 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A +L L + + I + I +++ +T D+ GN +T + + + K + Sbjct: 323 AATALLRHL-----QLSKHAQLIESCIHKIVTTNQARTVDIGGNTSTSEFFEILVKEVE 376 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 168/404 (41%), Gaps = 64/404 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + I GDGIGK+V P +VL+AAA G +S+ ++ +A + + +PDD + Sbjct: 35 VPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRV-FAGESAREKYDENLPDDTVNAI 93 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 G + P + R+ D Y N+RP GVP P+ P + Sbjct: 94 DEHRVAIKGPLTT----PVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKA--PEE 147 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTRRGV 167 +D RENTE Y+ + +V I T G Sbjct: 148 MDMVTFRENTEDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGS 207 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE----------- 215 R++R A + A R +T K N + + + E +A E YP+ Sbjct: 208 KRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVFAAPDSLW 267 Query: 216 ------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 + + + D + ++ + F V+ NL GD LSD A G +GI Sbjct: 268 ETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSDAAGAQIGGLGI 327 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP AN R L EPVHGSAP G+N+ANP A I +G +M D++G ++ A + Sbjct: 328 APGANFGDAR---VLAEPVHGSAPKRAGQNMANPTAMILSGRLMFDYMG-----WKDAAD 379 Query: 324 GILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + A+EE I+ G T D++ T + +DAI + I + Sbjct: 380 LVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 103/385 (26%), Positives = 169/385 (43%), Gaps = 49/385 (12%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++IA +PGDGIG EV + V + + + E++ G +P Sbjct: 6 PIKIAVLPGDGIGIEVTEATLPVFEVL----DVPVILNYGDI-GWEFWKKEGAAIPSRTW 60 Query: 64 EQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVRLF 112 + ++ D + GA+ + +++ R+ D + N+RP Sbjct: 61 QLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSI 120 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT---------------EHEVVI 157 P +F ++REN+EG Y E Sbjct: 121 DDQSKPF--------NFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASC 172 Query: 158 QESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 + ++ G+ R+ +AF+ A +T A K N L S + + E+ A+ YP+I+ Sbjct: 173 ALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQ 232 Query: 218 WDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPS 277 D ++D + + PE+F V+VA N+FGDILSD+G G +G+APSAN+ + ++ Sbjct: 233 ADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSY-- 290 Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 FEPVHGS P I KN ANP A +M+L+ G D I+ A+ +VI Sbjct: 291 -FEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPDR-----AKKIVNAVMQVIKEKR 343 Query: 338 -KTPDMKGNATTPQVADAICKIILR 361 T D+ G+ATT +A+A+ + R Sbjct: 344 FITYDLGGHATTTDMANAVIEHCAR 368 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 116/387 (29%), Positives = 164/387 (42%), Gaps = 52/387 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M RI +PGDGIG EV+ + V+ A + + + G+ +P Sbjct: 5 MLRKRICVLPGDGIGIEVMEAALPVIAAL----NLPFDLVPADI-GWQCWRAEGETVPAR 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVR 110 E ++ DA GA+ + +++ R+ D Y N+RPV Sbjct: 60 TWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVT 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGR-------------------VNEGT 151 G F V+RENTEG Y+ L Sbjct: 120 DMTG---------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + + + + TR G+ RI YAFE A+ +T K L S + EA A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP++ +++D + V +PERF V+VA N+FGDILSDLG G +G APS N Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 + FEPVHGSAP G N ANP A A A+ML+ LG F I A+ Sbjct: 291 SG---AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLG-----FPTESACISQAVSL 342 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKI 358 V +T D+ G+ TT QV +AI + Sbjct: 343 VSRTSTRTYDLGGSHTTAQVGEAIVQQ 369 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 125/356 (35%), Positives = 172/356 (48%), Gaps = 37/356 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+A IPGDGIG EV+ +RVL+A R + FE E + + G + ++ E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYE-GGVDVFQECGSPIREEDLE 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ R DA+ FGA P +P +L R+E Y NLR + P + Sbjct: 57 EIRRSDAVLFGATTTPFDLP---GYRSLILTLRKELGLYANLR---IIPDLRT------- 103 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + +VREN+EG Y +G V + + + TR G +RI R+A E A++R Sbjct: 104 -GREIVIVRENSEGLYFGIGAVV-----NGRAVDVRLITREGAERIARFAVEQAKARG-S 156 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K+N L ++ V +A + ID + V P V+++ N Sbjct: 157 FITFVHKANVL-TGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVILSEN 214 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSDL G+IGI PS N +LFEPVHGSAPDI GK IANPI I +G Sbjct: 215 LFGDILSDLATVHAGSIGIVPSGNYGD---GIALFEPVHGSAPDIAGKGIANPIGAILSG 271 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AM+LD+LG I AA+ + +G TPDM G A T V I I Sbjct: 272 AMLLDYLGLDGS-------LIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIE 320 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 107/414 (25%), Positives = 167/414 (40%), Gaps = 72/414 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG ++ RV+ AA E+ G + A + + G+ +P + + Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + G + P + + R+E D + LRPVR F GVP P+ +P Sbjct: 81 TIKEYLIAVKGPLTTPI----GGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVK--RP 134 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTRR 165 D+D + RENTE Y+ + + +V I ++ Sbjct: 135 QDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKE 194 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDER-------------------- 205 G +R++R A + A RK++T K N + + + + Sbjct: 195 GTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYD 254 Query: 206 -------------VEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSD 252 + AE +I DI + + +P DVV NL GD +SD Sbjct: 255 EIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISD 314 Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 A G IGIAP AN+N E T ++FE HG+AP G N NP + I + +ML+ LG Sbjct: 315 ALAAQVGGIGIAPGANINYE-TGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLG 373 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIIL 360 +Q+A + I +IE+ IA T D +T AD + K + Sbjct: 374 -----WQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK 422 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 105/382 (27%), Positives = 167/382 (43%), Gaps = 43/382 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++ +PGD IG E++ E +++L E G + D Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPG---V 115 + E DA+ G+VG P+ VP +S +L R+ D + N+RP R + Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLN 120 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 PL + +DF +VREN G Y + R V+R R + Sbjct: 121 QSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARVSA 168 Query: 176 ELAQSRPRKT---------LTSATKSNGLAISMPYWDERVEAMAE-NYPEIRWDKQHIDI 225 LA++ R + +A K+N LA S +W + E +P+I Q D Sbjct: 169 ALARTFGRGKNTDDKSPAIVWNADKANVLA-SGRFWRTVTHDIFEREFPDIELHDQLADS 227 Query: 226 LCARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFE 280 + V P +F+ V+ N FGDILSD+ G++G+ PSA++ E+ ++E Sbjct: 228 MAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYE 287 Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA------ 334 VHGSAPDI G ANPIA I + AM+L + + + + A+ + + Sbjct: 288 AVHGSAPDISGTGQANPIAQILSLAMLLRY----SFSMPRQADLLEDAVRKTLEVREHGG 343 Query: 335 HGPKTPDMKGNATTPQVADAIC 356 G +T D+ G+A+T V DA+ Sbjct: 344 LGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 103/406 (25%), Positives = 158/406 (38%), Gaps = 65/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWA-SCEYYSHHGKMMPDDWHE 64 I I GDGIG EV I+V A E+ +G + E + G +PD E Sbjct: 47 IGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLPDQSIE 106 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L + + P + R+ FD Y N+RPV+ FPG+P PL +P Sbjct: 107 VLRKIRVFLKAPLET----PVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPLR--RP 160 Query: 125 GDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFTRRGVD 168 +D + RENTE Y+ + + I ++ G Sbjct: 161 ELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPISKFGTQ 220 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA--------------ENYP 214 RI R A + A R+ +T K N + + E +A Y Sbjct: 221 RIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFEDELAQYG 280 Query: 215 E------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN 268 + + + D + + + + +DV++A NL GD +SD G +G+AP + Sbjct: 281 GSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLGVAPGLD 340 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + + + EPVHG+AP GKN NP ATI A +M FLG +++ I+ Sbjct: 341 VGD---WGMMAEPVHGTAPKYRGKNYVNPTATILALELMFRFLG-----WREVAEYIMKG 392 Query: 329 IEEVIAHGPKTPDMKGNAT-------------TPQVADAICKIILR 361 +E G T D+ T T + AD + +II R Sbjct: 393 VETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIKR 438 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 314 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 100/401 (24%), Positives = 158/401 (39%), Gaps = 62/401 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG E+ + ++ A E+ G + A + G+ +P + + Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLD 100 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L G +G P + RR FD Y +RPV G P+ P Sbjct: 101 VLKESIVGIKGPLGT----PVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPN--P 153 Query: 125 GDIDFYVVRENTEGEYSSLGGRVN-------------------EGTEHEVVIQESVFTRR 165 +D V RENT+ Y+ + EG +V I + Sbjct: 154 ERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEF 213 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN------------- 212 R +R A A +K + K N + + + +AE Sbjct: 214 KTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEA 273 Query: 213 ---YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL 269 +++ K D + + V++PE +DV++A NL GD +SDL + G G PS N+ Sbjct: 274 EPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNI 333 Query: 270 NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAI 329 +LFE HG+A DI GK IANP++ +GAMML+++G +++A + A+ Sbjct: 334 GDGY---ALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIG-----WKEAAQKVYDAV 385 Query: 330 EEVIAHGPKTPDM----------KGNATTPQVADAICKIIL 360 +A TPD+ T + A+ I K I Sbjct: 386 RRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 132/370 (35%), Positives = 182/370 (49%), Gaps = 26/370 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPD 60 M RI I GDGIG E++ +RVL A AE + +E +E A + Y G + Sbjct: 1 MTGTRIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAE 60 Query: 61 DWHEQLS-RFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 +L DA G VG PD PD + R D Y N+RPVR +PGVP Sbjct: 61 ADVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSR 120 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + + +D+ +VRENTEG Y+S G V V + TR G R+ R AF LA Sbjct: 121 VRADR---VDYVIVRENTEGLYASRGKGVGNRW---AVTDTLLTTREGTLRVARKAFTLA 174 Query: 179 QSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 R + +T KSN L S ++ E V +A +PE+ + ++ D V+ Sbjct: 175 AGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVELEYRYADAAAQDLVL 233 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 PERFDV+V N GD+LSDLG A G +G+ P+ N+ + FEPVHGSAPD+ G+ Sbjct: 234 CPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD---GAAYFEPVHGSAPDLVGR 290 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA--TTPQ 350 N ANP+ + A AM+LD LG+ DE + A+ V+A G + G Sbjct: 291 NRANPVGQLLAAAMLLDHLGHVDE-----AARLRRAVSAVLAFGTVRIEADGTVLGGAEA 345 Query: 351 VADAICKIIL 360 VADA+ + Sbjct: 346 VADAVIAALQ 355 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 12/365 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA I GDGIG +V I VL+ A + G A Y+ G + D E Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DAI+ GA+G P + + L+ R F Y +RPV+ +P P LA + Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120 Query: 125 GDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR-- 181 ID ++RE+TEG YS+ + + + V TR+ ++ R+AF LA+ R Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRE 180 Query: 182 --PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 LT K+N S+ ++ + + + + ++ ++D V +P FDV Sbjct: 181 RGHPGRLTCVDKANVF-TSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+A + LF+P HGSAPDI G++ ANP+A Sbjct: 240 LVMENMFGDILSDLAGGLVGGMGMAACGEIGD---TTGLFQPAHGSAPDIMGEDKANPLA 296 Query: 300 TIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAIC 356 I + A+MLD+L A I +A+E H + + G+ T V + Sbjct: 297 AILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKELL 356 Query: 357 KIILR 361 + + Sbjct: 357 GRVAQ 361 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 88/358 (24%), Positives = 161/358 (44%), Gaps = 25/358 (6%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + +PGDG+G E++ V +AAA + F++ + + + K+ + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL--EQVL 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P ++ ++ RR+ D + N+ V+ PG + Sbjct: 102 SSMKENKVAIIGKIHTPMEYKGELA--SYDMRLRRKLDLFANVVHVKSLPGYMT-----R 154 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RE TEGEYSSL G V+ + TR RI ++AF+ A + R Sbjct: 155 HNNLDLVIIREQTEGEYSSLEHESARG----VIECLKIVTRAKSQRIAKFAFDYATKKGR 210 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T+ K+N + + + + E +AE YP+I+++ ID C + V P +FDV+V Sbjct: 211 GKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ +L G G+ P + + E ++FE G+NIANP A + Sbjct: 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEY---AVFETGARHPFAQAVGRNIANPTAMLL 327 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + ML L N + + + + +T DM G +TT ++ + Sbjct: 328 SASNMLRHL-NLEYHSSMIADA---VKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 381 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 106/380 (27%), Positives = 157/380 (41%), Gaps = 39/380 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+ + I GDG G E++ VL AA GF L ++ A G+++P Sbjct: 1 MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRP-AGQGALRSVGELLPAS 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + R G P + + RRE D Y +RPVR++PG AG Sbjct: 60 TLDSIRRNGVALKGPTTTPI----GVGHRSVNITIRRELDLYACVRPVRVWPG-----AG 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT--------------EHEVVIQESVFTRRGV 167 ID VVRENTE YS L + + + T G Sbjct: 111 AVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPITPGGS 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI+ +A + A+ R+ + + + E + YP+I + +LC Sbjct: 171 RRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPVTVLC 230 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 V P DV+V NL+GD++SD+ A G +G+AP AN+ ++FE HGSAP Sbjct: 231 DSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR---TAVFEATHGSAP 287 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM---- 342 + G N NP A I +G M+LD LG I AA+ V+ G T D+ Sbjct: 288 EFAGSNRLNPTALILSGCMLLDHLGEAPT-----AARIRAAVRSVLEEGRSVTFDLLPPD 342 Query: 343 --KGNATTPQVADAICKIIL 360 TT A+A+ + + Sbjct: 343 RAARAVTTTAYAEAVIERLR 362 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 313 bits (801), Expect = 8e-84, Method: Composition-based stats. Identities = 102/417 (24%), Positives = 155/417 (37%), Gaps = 70/417 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ V AA ++ G A Y G+ +P Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D L + G + P I + R++ D Y RPV +PG P P+ Sbjct: 76 DKTLATLREYLVGIKGPLTTPI----GIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 P +++ V RENTE Y+ + V+ E Sbjct: 132 --VHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE----- 215 +++G R++ A + A + R TLT K N + + + + AE Y + Sbjct: 190 PISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDKVFTW 249 Query: 216 ---------------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGD 248 + + D + ++ PE F+VV NL GD Sbjct: 250 NQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATMNLNGD 309 Query: 249 ILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML 308 +SD A G IGIAP N+N +T ++FE HG+AP G+N NP + I +GAMM Sbjct: 310 YISDALAAQVGGIGIAPGGNIN-YQTGHAIFEATHGTAPQFAGQNKLNPTSIILSGAMMF 368 Query: 309 DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAICKIIL 360 D+LG + N I I+ I T D +T + + ++I Sbjct: 369 DYLG-----WDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIE 420 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 313 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 102/394 (25%), Positives = 167/394 (42%), Gaps = 55/394 (13%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK------- 56 ++ +PGD G +++ + VL + + + + + C + K Sbjct: 14 RYKVCYMPGDDSGFDMMEGALVVLLSM----DLPIDWVRADLGWCMWEKSVNKFGQGDPR 69 Query: 57 --MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 +P + +++ DA A+ V ++L+ R+ FD Y+NLRP + P Sbjct: 70 CNTVPPETIDKIRSSDATLMAAITSKSGV---KGFKSAILQMRQLFDLYINLRPAKTLPD 126 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLG-------------GRVNEGTEHEVVIQESV 161 + PL G ID + RENTE YS++ G +V + V Sbjct: 127 LGSPLKGD--PKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDVAVSWRV 184 Query: 162 FTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWD-- 219 F+ G +RI+R AFE A+S R + K+N + + +A+ Y + Sbjct: 185 FSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQYGITGI 244 Query: 220 KQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLF 279 +++ D + P+ + V+V SN+FGDILSD TG +G APS N+ ++F Sbjct: 245 EENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGEN---TAIF 301 Query: 280 EPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH---G 336 EP GS P + NP A + MML++LG QA I AI EV+ Sbjct: 302 EPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLG-----LDQAGQKIEWAINEVLKENRPK 356 Query: 337 PKTPDM-----------KGNATTPQVADAICKII 359 T D+ + A+T ++A AI + I Sbjct: 357 TLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 313 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 157/360 (43%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PG GIG E + + + G + FE ++ Sbjct: 56 RHAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDPTMDNDDD----VQYAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + + + R E D Y + + +PGV + Sbjct: 108 TTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVAT-----R 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID ++R+NTEGEY+ L G VV V T +R+ R+AFE A+ R Sbjct: 160 HKDIDVVIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAKKNGR 215 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + E +A+ YP+I D ID C + V +P +FDV++ + Sbjct: 216 KKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLMT 275 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G I+S++ G G+ N ++FEP + I GKNIANPIA I Sbjct: 276 NLYGSIVSNVVCGLLGGAGLLSGRNYGDHY---AVFEPGTRNTGTAIAGKNIANPIAMIN 332 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIILR 361 A ML+ LG+ Q + + AI + I TPD+ G+ T+ V AI + + R Sbjct: 333 ASIDMLEHLGH-----QFHASLLRRAINKTINVDRVLTPDLGGSNTSTDVVGAILQNVGR 387 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 309 bits (792), Expect = 9e-83, Method: Composition-based stats. Identities = 96/407 (23%), Positives = 164/407 (40%), Gaps = 63/407 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG---FALSFEQMEWASCEYYSHH-GKM 57 K I I GDGIG ++ P I+V+ AA E+ +++ ++ + Sbjct: 26 PKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTW 85 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P + + + + G + P + + R++ D YV RPVR F GVP Sbjct: 86 LPQETLDAVRDYVVSIKGPLTT----PVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPS 141 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQ 158 P+ +PGD+D + REN+E Y+ + + +V I Sbjct: 142 PVK--KPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIG 199 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY----- 213 ++ G R++R A + A R ++T K N + + + + +A + Sbjct: 200 IKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAEL 259 Query: 214 ---------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + D + + +++P +DV+ NL GD LSD A Sbjct: 260 LDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEV 319 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G IGIAP ANL+ ++FE HG+AP G++ NP + I + MML +G + Sbjct: 320 GGIGIAPGANLSDS---VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRHMG-----W 371 Query: 319 QQAHNGILAAIEEVIAHGPKTPD----MKGN--ATTPQVADAICKII 359 +A + I+ IA T D M G + + DA+ + Sbjct: 372 TEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 308 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 143/385 (37%), Positives = 196/385 (50%), Gaps = 35/385 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++ ++A +PGDGIG EV+ L+A G AL ++ W + ++ HG+MMP DW Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEAL---PGPALVLTELGWPAHAWHRDHGEMMPADW 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISL-------WGSLLKFRREFDQYVNLRPVRLFPGV 115 QL+ +DA+ GA+G P D LL+ R+ D + RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 P PL+ + D V+REN+EGEY GGR+ GT E Q VFTR G +RI+R+AF Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAF 182 Query: 176 ELA----------QSRPR---------KTLTSATKSNGLAISMPYWDERVEAMAENYPEI 216 E A PR + TK N + + W E +A YP I Sbjct: 183 ERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPGI 242 Query: 217 RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP-ERTF 275 + ID C +FV QP +FDVVVASNL GDIL+DL G +G+APSANLNP +R+ Sbjct: 243 ATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSV 302 Query: 276 PSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 P LFEP HGSAPDI G + A+P A + A ML+++G D ++ + A+ E IA Sbjct: 303 PPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE 362 Query: 336 GPKTPDMKGNATTPQVADAICKIIL 360 M G +V A+ + I Sbjct: 363 HG----MGGR-GCAEVGRAVAQRIR 382 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 112/373 (30%), Positives = 178/373 (47%), Gaps = 42/373 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG----K 56 M K + A + GDGIG EV+ +RVL+ + L A E + +G Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCE-----AGSEQWDKNGRKDAS 53 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 +PD + L D + G +P + + R++FD Y N+RP + + Sbjct: 54 YIPDVTMKILEETDCCFKGPTTT---IPVPGAPRSVAVTLRQKFDLYANIRPTKTYD--- 107 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 +D RE TEG Y+ + ++ + I TR+G R++ A + Sbjct: 108 ---RLTPDRKLDCVCFREATEGLYTGVEAKIT----DDAAIAIRKITRQGSRRLIDSAVD 160 Query: 177 LAQSRPRKTLTSATKSNGLAISMP-YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 A K + + TK N L + +WDE +A+ +I + +ID + + V+ E Sbjct: 161 WANKFNMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQMVIATE 218 Query: 236 RFD--VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 +F+ V+V++NLF DI+S+L A G+IG+ SAN+ ++FE HGSAP G+N Sbjct: 219 QFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDNY---AMFEAAHGSAPQFAGQN 275 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 NP AT+ +GA M D+LG D R + I AA E+VI G T D+ G+A+T Q+ Sbjct: 276 KVNPTATVLSGAWMADYLGERDVR-----DAIFAATEQVINEGKAVTWDIGGDASTTQMT 330 Query: 353 DAIC----KIILR 361 DAI + + + Sbjct: 331 DAIITYAKEKLRK 343 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 307 bits (786), Expect = 5e-82, Method: Composition-based stats. Identities = 97/400 (24%), Positives = 156/400 (39%), Gaps = 61/400 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKMMPDDWHE 64 +A GDGIG E++ +VL AA ++ +G E A E G ++PD + Sbjct: 35 VAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLPDGTLQ 94 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 G + P + R D Y N+RPV+ + G P P P Sbjct: 95 AFKLARVNLKGPLTT----PVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTP--HCHP 147 Query: 125 GDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFTRRGVD 168 +ID+ + RENTE Y+ + + I ++ Sbjct: 148 ENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPISKWRTQ 207 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV---------------EAMAENY 213 R +R A E A K +T K N + + + + E + Y Sbjct: 208 RHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEEVNTKY 267 Query: 214 PE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSA 267 I + + D + + + +P ++V+V NL GD +SD A G IG+A Sbjct: 268 GGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIGMAAGL 327 Query: 268 NLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGIL 326 ++ ++ EPVHGSAP GKN+ NP A I +G +L DF+G + + + Sbjct: 328 DMGD---GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKL-----LVE 379 Query: 327 AAIEEVIAHGPKTPDM----KG--NATTPQVADAICKIIL 360 A+++ IAH T D+ G +T + D + I Sbjct: 380 YAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 304 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 112/374 (29%), Positives = 176/374 (47%), Gaps = 24/374 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M T IA + GDGIG EV+ E ++VL+ +R + + + Y++ G PD Sbjct: 1 MTTYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFA-MGHAFPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-----VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + + DAI G +G D G+LL RR ++ + N RPV L G+ Sbjct: 60 ETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGL 119 Query: 116 P--CPLAGKQ-PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL ID ++RE G Y V + + + +I++ Sbjct: 120 AHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVK 179 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 FE++ R +K + + KSN L S W+E VE ++NYPE+ +D + Sbjct: 180 VGFEVSMKR-KKVMHNIHKSNVLKSS-VLWNEIVEEESKNYPEVEVKNILVDAAATYLCL 237 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P FDV+V N+FGDILSD G G++G+ PSA P++++ +EP HGSAPDI GK Sbjct: 238 NPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSY---YEPSHGSAPDIAGK 294 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM-----KGNAT 347 IANP + I + A+ML+ ++ + AA++ V +G T D+ + Sbjct: 295 GIANPYSMIGSVALMLE----MSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVS 350 Query: 348 TPQVADAICKIILR 361 T + D +C + + Sbjct: 351 TAEFGDLVCAELAK 364 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 304 bits (778), Expect = 4e-81, Method: Composition-based stats. Identities = 116/369 (31%), Positives = 178/369 (48%), Gaps = 31/369 (8%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + EG++VL A +E G + E + Y P D ++ D I GAVGW Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 80 PDTVPDHISL---------WGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG-----KQPG 125 PD + + ++ R + Y N+RP++L+PGV + G + G Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK- 184 +D ++RENTEG Y+ GG++ G + +V I V TRR ++++R+AFEL + R + Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 185 ------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +T+ K N L + + + YPEI D +D V QPE +D Sbjct: 181 PKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYD 239 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V V SN+FGDI++DL G +G+A N+ ++FEP+HGSAP GK+ NPI Sbjct: 240 VCVTSNMFGDIVTDLASTLQGGMGMAVGGNIG---KHNAMFEPIHGSAPKHAGKDKVNPI 296 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVA 352 A I + L++L D +A I AA+ EV+ G T D+ GN + +V Sbjct: 297 AMILSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVG 356 Query: 353 DAICKIILR 361 AI + +R Sbjct: 357 SAIAEAAVR 365 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 91/409 (22%), Positives = 163/409 (39%), Gaps = 71/409 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEY--YSHHGKMMPDD 61 I I GDGIG ++ P I+V+ +A ++ +++ ++ Y + H ++ P++ Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 62 ------WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 E ++ + G + P + R++ D YV LRPVR + G Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPI----GEGFRSLNVALRQKMDLYVCLRPVRWY-GS 146 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVV 156 P P+ P +D + REN+E Y+ + + Sbjct: 147 PSPVKE--PQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSG 204 Query: 157 IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENY-- 213 + ++ G +R++R A E A + ++T K N + + + + A+A + + Sbjct: 205 VGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNA 264 Query: 214 -----------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 EI D + +++P + V+ NL GD +SD A Sbjct: 265 QVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAA 324 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G IGIAP ANLN +FE HG+AP G + NP + I + MML +G Sbjct: 325 MVGGIGIAPGANLND---TVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMG---- 377 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKII 359 + +A + I++A+E+ I T D + A + + + Sbjct: 378 -WVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 61/399 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA I GDG+G++V+P +V+ +A + + Q+ + G P + Sbjct: 34 IAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDWFPQETI 93 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P + R+E D +VN+R ++ F +P PL Sbjct: 94 NAVRECKIAIKGPLTTPL----GGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPY 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTR 164 + V+R+++E YS + + +V I ++ Sbjct: 150 L--TNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISK 207 Query: 165 RGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NY---------- 213 G +R++RYA A ++LT K N L + + A+A+ Y Sbjct: 208 EGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQAIDDENGRW 267 Query: 214 --------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 P + + D + + +M PE+FDVV +N GD L+D+ A G +GI P Sbjct: 268 LHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADMLSAQVGGVGIMP 327 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGI 325 +ANLN E + FEP HG+ I G+N ANP ++I + +ML F+ ++ +A N I Sbjct: 328 AANLNNE---VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKFM-----QWHEAANLI 379 Query: 326 LAAIEEVIAHGPKTPDMKG------NATTPQVADAICKI 358 A+E +A G T D+ + A + + Sbjct: 380 ENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 96/402 (23%), Positives = 155/402 (38%), Gaps = 64/402 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH---HGKMMPDDW 62 I I GDGIG +V P ++V+ AA + +G E +E + E + +P++ Sbjct: 29 IPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEET 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 L + G + P + + R+ D YV RPV+ F GVP P+ Sbjct: 89 LNILQEYKVSIKGPLTT----PVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFT 163 +P ++D + RENTE Y+ + + V I + Sbjct: 143 RPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVS 202 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY---------- 213 + G R++R A + A + ++T K N + + + + +A Sbjct: 203 KEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLLHGGP 262 Query: 214 ----------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 EI D + + +++P + V+ NL GD LSD A G IGI Sbjct: 263 WCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQVGGIGI 322 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP ANL E ++FE HG+AP GKN NP + I + MML +G + + Sbjct: 323 APGANLGDE---VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWLE------AD 373 Query: 324 GILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKII 359 +L + I T D + + D I + Sbjct: 374 LLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 176/355 (49%), Gaps = 30/355 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG+EV+P + VLQA E SF + + A + G +P+ +E Sbjct: 7 HEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTE-KQAGDDTRDQTGAALPETTYE 62 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA FGA G +L R +VN+RP R +PGV Sbjct: 63 AAADADATLFGAAGETAA--------DVILPLREAVGSFVNIRPARAYPGV-----DALQ 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + D +RENTEG YS R++E ++ V T +++ YA R Sbjct: 110 PETDLVFLRENTEGVYSGHEDRLSE----DLSTLTRVITTSASEQLAEYACSYVTERSID 165 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 + K+N + + + + V +A + ++ ++ +D R + P +FDVVV N Sbjct: 166 GFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLNPTQFDVVVCPN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GD+LSDL G +G+ PSAN+ +LFEPVHG+APDI G IANP A+I + Sbjct: 225 LAGDVLSDLAAGLVGGLGLLPSANIG---QTNALFEPVHGTAPDIAGDGIANPSASILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L++LG D A + A+E V+ GP+TPD+ GNA+T V +A+ + + Sbjct: 282 GMLLEYLGETD-----AATNVQMAVESVLNSGPRTPDLGGNASTEAVVNAVIEQL 331 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 297 bits (760), Expect = 5e-79, Method: Composition-based stats. Identities = 87/374 (23%), Positives = 149/374 (39%), Gaps = 39/374 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ + GD IG EV+ E + + +G + + H + + Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGG-SCLDQHDCPIQES 68 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHI--SLWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 ++ S A+ G+VG P +L+ R+ + Y N+RP ++ Sbjct: 69 TLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L ++ +REN G Y + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI--RWDKQHIDILCARFVMQP 234 LA S + S K+N +A S + E + + +P++ + Q +D P Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN-------PERTFPSLFEPVHGSA 286 + + VV+ NLFGDILSDL G++G+ SA ++ R +++PV GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 PDI GK IANPI + +M + +A + I +AI++ + G T D+ G Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRW----SLGLPKAADAIDSAIKDCLESGQCTRDVGGTL 345 Query: 347 TTPQVADAICKIIL 360 +T Q A+ + I Sbjct: 346 STQQAGSALRQSIQ 359 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 96/405 (23%), Positives = 158/405 (39%), Gaps = 69/405 (17%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC----------------- 48 ++ +PGDGIG E+ + A + ++ + Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYA----NIPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 49 -EYYSHHGKMMP-----------------------DDWHEQLSRFDAIYFGAVGWPDTVP 84 E G+ P D H+ + + G D Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGPFITRDVSK 154 Query: 85 DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLG 144 + ++ Y ++ PV+ +P P D+D VVRENTE EYS L Sbjct: 155 SIDRMLAL------KYGLYAHVVPVKAPQNLP-PSVFTPFRDVDMVVVRENTEAEYSGLE 207 Query: 145 GRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE 204 +V G VV + TR G RI ++AFE A+ R + + K+N + S + E Sbjct: 208 HQVQPG----VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIE 263 Query: 205 RVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVVASNLFGDILSDLGPACTGTIG 262 + +A+ YP+I++ + +D + V P FD VVV NL+G I+S+ + G +G Sbjct: 264 CCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVG 323 Query: 263 IAPSAN---LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQ 319 + N +N + A DI G+ IANPI I + MLD +G Sbjct: 324 VISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMG-----MN 378 Query: 320 QAHNGILAAIEEVIAH---GPKTPDMKGNATTPQVADAICKIILR 361 N I A++E + + TPD+ G ++ +A+ + I + Sbjct: 379 THANRIKFALKETLLNANPKILTPDIGGTGSSVSFIEAMMRHIPK 423 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 294 bits (754), Expect = 3e-78, Method: Composition-based stats. Identities = 120/364 (32%), Positives = 173/364 (47%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + RI AIPG+GIG EV+ +++LQ A+ GF L W + G P Sbjct: 7 ASYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQ-VDYGWLGATAFEQLGSYFPQAT 65 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLA 120 E D I FGAV G LL+ R+ FD + NLRP+R + L Sbjct: 66 TELCDGADGIVFGAVS-----------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLR 114 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ +D +VRE G Y GR ++ + + + RI R A E AQ Sbjct: 115 PEKIQGLDILIVRELVSGIYFGPSGRSSDERGN-YGYHTMRYYDEEIRRIARKALEQAQY 173 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R LT A K N L +W V+ A +P + + +D L + V+ P+RFDV+ Sbjct: 174 R-RGLLTVAHKENALPH--LHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 +ASNLFGDILSD+G A G+IG+ SA+LN L+E +HG+APDI G IANP+ T Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNAN--GFGLYEAIHGTAPDIAGLGIANPLGT 288 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGN---ATTPQVADAI 355 + A +ML G Q + ++A G +T D+ +G T + D + Sbjct: 289 LGACVLMLQQWGEVQAAQQIIAAQ-----DRILAKGYRTADLFTQGEEILVNTATLVDLL 343 Query: 356 CKII 359 + + Sbjct: 344 LEEL 347 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 98/361 (27%), Positives = 174/361 (48%), Gaps = 31/361 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + + +PGDGIG E++ + I+++++ G+ ++ + ++ Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKSC-IYTGYKINIIYNYIGGIS-IDKFNTPITNNLIS 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + D I+ G VG LLK R++F+ + N+RP++ CP Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK---- 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV----VIQESVFTRRGVDRILRYAFELAQS 180 +ID +VRE G Y ++ +++ ++ + + R+ R +F LA + Sbjct: 110 -NIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLALN 168 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R +K L S KSN L + W + + + + Y +++ +ID + +FDV+ Sbjct: 169 R-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFDVI 226 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 + SNLFGDI+SDL TG++G+ PS ++N SLFEP HGSAPDI KNIANP+ Sbjct: 227 ITSNLFGDIISDLCSLLTGSLGMLPSISINN--KSLSLFEPCHGSAPDIANKNIANPVGA 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + + MM +++ N + N + +I +V+++G T DMK +T + D Sbjct: 285 LLSLVMMFEYVLNDF----KLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDL 340 Query: 355 I 355 + Sbjct: 341 V 341 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 289 bits (741), Expect = 8e-77, Method: Composition-based stats. Identities = 92/359 (25%), Positives = 161/359 (44%), Gaps = 28/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + G GIG E++ +RVL+AA G LS+E +S + ++ D+ Sbjct: 37 KTNVTILTGSGIGPEIMDHTLRVLKAA----GAPLSYEIFALSSKDGSKNND---FDEAL 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P + + FR+ D +V + + FPG+ + Sbjct: 90 TSIRRNRVALKGNIELQSKNP---HIKSRNIIFRKTLDLFVYILFCKTFPGLS-----NK 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G+ID V+R+NTEGEY L G+ V V TR ++R++ +AF+ A + R Sbjct: 142 FGEIDITVIRQNTEGEYLMLEHEPRTGS----VESLKVLTRFNLERLIEFAFDYALTNDR 197 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T +N ++ + ++++YP I+ + +++ + P FDV++A+ Sbjct: 198 KLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVILAT 257 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL G ++S+ G G+ N + + ++FEP I G N ANPIA I Sbjct: 258 NLNGSMISNYLNGMLGGPGLTSGINFSAD--GIAVFEPGARNKGSSIVGLNRANPIAMIM 315 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G +L LG + I ++ + +TPD+ G AT + D I + I Sbjct: 316 SGINLLHHLGY-----NKTAEMIHNSVYATLVYDKIRTPDIGGQATAEETVDHIIRHIR 369 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 118/402 (29%), Positives = 166/402 (41%), Gaps = 65/402 (16%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 RI +PGDGIG E+ ++ W + + HG +P + Sbjct: 13 APRRITLLPGDGIGPEITDACRGLIADVFPHWELTET-----QIGWSQWRAHGNPVPQET 67 Query: 63 HEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 E L R DA A+ P ++ +L+ R+ D + N+RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-T 126 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSS----LGGRVNEGTEH-------------- 153 PG DF +VRENTEG YS + H Sbjct: 127 LPGAAA----------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVA 176 Query: 154 -------EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--------LTSATKSNGLAIS 198 EV + V T R+ R A +LA +R +T A K N L S Sbjct: 177 RAVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDS 236 Query: 199 MPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 VE +AE YP++ +D + D + + V P RFDV++A NL GDILSD+G Sbjct: 237 ARVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLI 296 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +G+A SAN+ ++FEPVHGSAPDI G+ IANP A + + AM + LG Sbjct: 297 GGLGLAASANVGDN---FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSEL 353 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 A + A+ P T D+ G ATT + A+ + Sbjct: 354 APAA-KLREAVYAATRTAP-TLDLGGTATTSEFVAAVRAELG 393 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 97/368 (26%), Positives = 172/368 (46%), Gaps = 40/368 (10%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER--WGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I GDGIG + + R+L+ + + F+ ++ + E + +P + + Sbjct: 44 IGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAEVLK 103 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L I G P ++ + + R+E D + N+RPVR+ Sbjct: 104 ELKECHVILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE----------- 152 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID+ RENTEG Y+ G ++ + +V T G +RI+R AFE A++ + Sbjct: 153 QGIDWTFYRENTEGAYAV--GSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKT 210 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV--MQPERFDVVVA 242 +T+ TK+N + + + + +A++Y +I D +IDI+ A+ + + + F V+V Sbjct: 211 RVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKDFQVMVL 270 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANPIA 299 NL+GDI++D G +G A SAN+ S+FE +HGSAP + + A+P + Sbjct: 271 PNLYGDIITDEAAEFQGGVGTAGSANIGKRY---SMFEAIHGSAPRMVQEGRDQYADPCS 327 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIE-------EVIAHGPKTPDMKGNATTPQVA 352 I AGAM+L +G G + + + A++ +++ G T AT + A Sbjct: 328 VIRAGAMLLAHIGYG-----KEADKLYQALDICTVTEKKLVITGRNTG-----ATGAEFA 377 Query: 353 DAICKIIL 360 D I + I Sbjct: 378 DYIMETIE 385 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 287 bits (735), Expect = 4e-76, Method: Composition-based stats. Identities = 84/298 (28%), Positives = 130/298 (43%), Gaps = 25/298 (8%) Query: 39 SFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRR 98 FE++ +S + + R G + +P S R Sbjct: 1 DFEEVHVSSNADEEDIRNAI-----MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRT 53 Query: 99 EFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 D Y N+ + PGV + DID +VRENTEGEYSSL G VV Sbjct: 54 SLDLYANVIHWKSLPGVVT-----RHKDIDILIVRENTEGEYSSLEHESVAG----VVES 104 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T+ RI YAF+LAQ RK +T+ K+N + + + + +A YP+I + Sbjct: 105 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITF 164 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 + +D + V +P++FDV+V NL+G+I++++ G G+ AN ++ Sbjct: 165 ENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AV 221 Query: 279 FE-PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 FE + I KNIANP AT+ A MMLD L + I A+ + + Sbjct: 222 FETATRNTGKSIANKNIANPTATLLASCMMLDHL-----KLHSYATSIRKAVLASMDN 274 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 89/366 (24%), Positives = 158/366 (43%), Gaps = 30/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAA--ERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + +PGDGIG ++ + +RV + E + F + + E + +P + Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E D + G P ++ + RR Y +RPVR+ Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE--------- 157 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ REN EGEY + G + ++ + V TR G +RI R AFE A++ Sbjct: 158 --KGIDWTFFRENIEGEY--IWGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNG 213 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ--PERFDVV 240 + +T TK+N + + + + A+ + YP I ++ +D + A+ Q + V Sbjct: 214 KTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 + NL+GDI++D+ G +G A S+N+ + +LFE +HG + N A+P Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQY---ALFEAIHGVGNFLVQHNRAQYADP 330 Query: 298 IATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 + I A M+ +G + E+ +A + +V+ T D G AT + D + Sbjct: 331 CSLIRAMGEMISHIGYPEKKEQLVKALDICTRTERKVV----ITTDKDG-ATAEEFTDYL 385 Query: 356 CKIILR 361 + R Sbjct: 386 LDTLQR 391 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 276 bits (706), Expect = 1e-72, Method: Composition-based stats. Identities = 92/361 (25%), Positives = 154/361 (42%), Gaps = 29/361 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ + G G+G++ R+ AA + FE + A H +P + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFE-VHLAGRMALEHGKDALPKATFDA 57 Query: 66 LSRFDAIYF------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + VG P + FRR+ + ++RPV PG+P Sbjct: 58 IRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSRF 117 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 +DF + RE TE Y++ + G VV + T R + AF+ A+ Sbjct: 118 T-----GVDFLLFREITEDLYTASEHEIVPG----VVQSFKIVTEAACLRFFKLAFDTAR 168 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RKT+ K+N L ++ + E +A+ YPEI +D C + V +P++F+V Sbjct: 169 KRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEV 228 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + A NL+GD+LSDLG G + + N +++E V+G++ + +++NP+ Sbjct: 229 LAAGNLYGDLLSDLGAGLVGGVSTTAAINKG---NGTTVYEAVYGASHEAVPPDMSNPLP 285 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I +L LG I A+E V+ G +T D+ G ATT DAI Sbjct: 286 LILPAIELLKDLGETGT-----AGRIQKAVETVLLEGRIRTRDIGGTATTTAFTDAIVSR 340 Query: 359 I 359 + Sbjct: 341 M 341 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 276 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 109/368 (29%), Positives = 178/368 (48%), Gaps = 45/368 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIGKE++P+ ++ + F S E Y + G + D ++L Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTFY-----NISSERYINKGITIKDSEIDEL 58 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +++I+FGA+G P I G +L+ R+E D Y+N+RP F + + Sbjct: 59 KSYNSIFFGAIGDFRVKP-GIMEQGVILRLRKELDLYMNIRPAISFSRITG-------NN 110 Query: 127 IDFYVVRENTEGEYSSLGGRVNEG-------------------TEHEVVIQESVFTRRGV 167 I ++REN E YS + G +NE ++ + +R+ + Sbjct: 111 IHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNL 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 R A+++A + +T+T K+N + + W E +E + + ++ D L Sbjct: 171 KRFFNMAYKIADT---ETVTITDKANAVDMYS-LWREIAIEESEP-AGKKINFEYADSLA 225 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P ++ ++A NL+GDILSD+ A G +G APS N+ + S+FEPVHGSAP Sbjct: 226 YNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD---YSSMFEPVHGSAP 282 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 DI GKNIANP+A+I + MML L + + ++E VI +G + GNA Sbjct: 283 DIAGKNIANPVASILSCIMMLKHLNQTET-----AGIMEKSVENVIRNGTIPIESGGNAG 337 Query: 348 TPQVADAI 355 T + + + Sbjct: 338 THEFINKV 345 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 92/367 (25%), Positives = 161/367 (43%), Gaps = 34/367 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS--CEYYSHHGKMMPDDWH 63 ++ +PGDGIG ++ + V + ++ E + E + K +P Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAVL 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E D + G P +L + RR+ Y +RP+R+ Sbjct: 99 EACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE---------- 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ID+ REN EGEY + G ++ I + ++ G +R+ R AFE A+S + Sbjct: 149 -KGIDWTFFRENIEGEY--IWGNKGICVGDDLAIDFKILSKPGAERLFRNAFEYAKSSGK 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE---RFDVV 240 +T ATK+N + + + + AM + YP I ++ ID L A+ + PE V Sbjct: 206 TNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DPEFNAGMQVF 264 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 V NL+GDIL+D+ G +G A S+N+ + ++FE +HG + N A+P Sbjct: 265 VLPNLYGDILTDIAAEYQGGLGTASSSNIGDQY---AMFEAIHGVGVYLVEHNRAQYADP 321 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIE---EVIAHGPKTPDMKGNATTPQVADA 354 + I A M+ F+G ++R + + A++ +V T D G AT + A+ Sbjct: 322 SSLIRAMGEMMAFIGYPEKR-----DRLFKALDFCTKVERKAVITTDKDG-ATAEEFAEY 375 Query: 355 ICKIILR 361 + + + + Sbjct: 376 VVETLHK 382 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 272 bits (697), Expect = 9e-72, Method: Composition-based stats. Identities = 95/367 (25%), Positives = 154/367 (41%), Gaps = 17/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + IA IPGDG+G E+ E + L+ A E +G + F + A +P + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEA-IAGTAALDRGQCPLPRE 69 Query: 62 WHEQLSRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 + D+I G AVG + L R ++RP + C Sbjct: 70 SLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 118 PLAGK-QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + + +D ++R+ G ++ G+ + + + R AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFT-TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA SR RK +TS K+ L S W + +E +YPEI + +D + V P+ Sbjct: 189 LAASRKRK-VTSLDKA-ILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDA 246 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+VASN+FGDI++D TG P+ +LN ER +H ++ G AN Sbjct: 247 FDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRAN 306 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPD--MKG--NATTPQVA 352 P+ I A AMML++ + G+ A+ V+ G G A T + Sbjct: 307 PVGMILAAAMMLEY----SFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIG 362 Query: 353 DAICKII 359 +A+ + + Sbjct: 363 EAVRECL 369 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 272 bits (695), Expect = 2e-71, Method: Composition-based stats. Identities = 77/359 (21%), Positives = 161/359 (44%), Gaps = 37/359 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 KT ++ I G+G+G+E++ V+ A + ++ + E+ + + + Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEV 136 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L G V + R++F Q+ + G+ P Sbjct: 137 LKSLRANKVGIKGPVDSRHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY--- 183 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 GD D ++R+ EG+YS + V G V+ V T G RI + F A Sbjct: 184 --GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNK 237 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T A K+N + ++ + E + A A+ + ++ ++++++D + +++P + DV+V Sbjct: 238 RKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMV 297 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +S+++GD+L + G GI P +++ + ++F+ + + GK++ANP + Sbjct: 298 SSSMYGDVLRVIAGGMMGVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANPTGPL 354 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + A+ML + + + + + AI +V +TPD+ G A + A+C + Sbjct: 355 LSAALMLRHV-----KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 271 bits (692), Expect = 4e-71, Method: Composition-based stats. Identities = 118/376 (31%), Positives = 177/376 (47%), Gaps = 29/376 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IA IP DG+GK+V+P G + +Q A E GF L E A EY GKM D Sbjct: 1 MKKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE-AGVEYAVKTGKMCED 59 Query: 61 DWHEQLSRFDAIYFGAVGWPD------TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + E +++ DA+ G+ G D P + + L R + LRP+RL G Sbjct: 60 NLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + CPL + +ID +VR+ EG Y G + + V TR ++ Sbjct: 120 IDCPLRNR--EEIDVLLVRQLAEGFYIRPGHMI----GEDAAYDTIVVTRNVTEKFADTC 173 Query: 175 FELAQSR------PRKTLTSATK-SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 F LA+ R +K +T K N ++ + ++ YP+I +D L Sbjct: 174 FRLARGRHGRRQDGKKMVTLGNKHGNV--TCFDFYRKIFTEVSAGYPDIGLQFTQVDALA 231 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P+RFDV+ N+ GDI+ D+G TG +GI P+A++ F P HG+ P Sbjct: 232 EHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVG---GVTPQFRPNHGTFP 288 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAH-GPKTPDMKG 344 GK ANP+A+I ++LD LGN GD+ ++ I A+E + GP+T D+ G Sbjct: 289 RAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGG 348 Query: 345 NATTPQVADAICKIIL 360 A T A+A+ K + Sbjct: 349 TANTFATAEAVFKAME 364 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 150/359 (41%), Gaps = 21/359 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG+G+G EV+ + +L+ E G + G+ + + Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV---- 85 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAGKQP 124 F A F G P + RR FD Y L P+R +P + L + Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAA 142 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VREN G Y G EG Q + V+RILR A LA R R Sbjct: 143 RSADVLIVRENASGLYCGEWGSEGEGA-ARSAYQVCRYRADEVERILRTALRLAGQR-RG 200 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L TK G+ W + + A+A + +R +D + + P +FDV+V N Sbjct: 201 DLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPN 260 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDIL D G G+ G++ S N ++++ HG+A D+ G++ ANPI + + Sbjct: 261 MFGDILGDCGSLLMGSRGMSWSGNYGA--AGQAVYQTAHGAAWDLAGRDRANPIGQVCSL 318 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAICKII 359 AMML R + + AI +A G +T D++G T + A+C + Sbjct: 319 AMMLR----ESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQALCASL 373 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 266 bits (680), Expect = 8e-70, Method: Composition-based stats. Identities = 113/372 (30%), Positives = 161/372 (43%), Gaps = 72/372 (19%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 ++T+RI IPGDGIGKEV+P G R+L+A G F + A E + G +PD Sbjct: 3 IRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLH-AGFETFERTGAALPDK 61 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L D FGAV P + S ++ R++ D Y N+RPV+ P Sbjct: 62 TVEILRNECDGALFGAVSSPSSPVKGYS--SPIVALRKKLDLYANVRPVKTVLSAAKP-- 117 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ID +VRENTE Y + V + R RI A ++A Sbjct: 118 ------IDMVIVRENTEDLYVKEETTRDTPDGK-VAEAIKRISERASHRIATMAGDIALR 170 Query: 181 RPRKT------------LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 R + +T KSN L + Sbjct: 171 RQKIRAAGAPSIHQSPLVTITHKSNVL-----LRLK------------------------ 201 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 +V+V NL+GDILSD A G++G+ PSAN+ ++ EP HGSAPD Sbjct: 202 ---------NVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE---GFAIGEPCHGSAPD 249 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNAT 347 I G+NIANPIAT+ + A+ML+FL + AA++ + G +PD+ G A Sbjct: 250 IMGQNIANPIATLRSAALMLEFLDEEAAAAKIY-----AAVDANLTEGKLLSPDLGGTAK 304 Query: 348 TPQVADAICKII 359 T +V + I + + Sbjct: 305 TTEVIEDILRRL 316 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 264 bits (676), Expect = 3e-69, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 112/258 (43%), Gaps = 31/258 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ I GDG G E+ RVL+A G A ++ + A + G +PD E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA----TGVAFDWDIQD-AGVDVMEQLGTPLPDSVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + P + R+E D Y +RP R +PGV + Sbjct: 58 SIRSTKVALKAPITT----PVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRS-----RF 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-----------------VIQESVFTRRGV 167 +ID VVRENTE Y+ + E+ I + G Sbjct: 109 ENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGS 168 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 +RI+R+AFE A++ RK +T+ K+N + S + E +A+ YP+I +D + +D +C Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMC 228 Query: 228 ARFVMQPERFDVVVASNL 245 + V +PE +DV+V NL Sbjct: 229 MQLVQKPELYDVMVLPNL 246 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 260 bits (665), Expect = 6e-68, Method: Composition-based stats. Identities = 103/367 (28%), Positives = 141/367 (38%), Gaps = 43/367 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E ++VL+A F Q H + Sbjct: 1 MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTA 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-SLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 DAI GA+G P+ P LL+ R+E Y NLRP Sbjct: 61 KALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL DF VVRE T G Y E + ++R ++RI R A Sbjct: 121 SPLKADVCRGTDFIVVRELTGGIYFGA---RTEDDGSGFAMDTDAYSRAEIERIARLAGF 177 Query: 177 LAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA + P + S K+N LA S + E A +P++ Q ID V P Sbjct: 178 LALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 + VVV SNLFGDI+SD G+IG I Sbjct: 238 ALNGVVVTSNLFGDIISDEASVIPGSIGA-----------------------------GI 268 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NPI TI + AMML + N + + A + +G +T D+ G+A T Q+ADA Sbjct: 269 VNPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTA----LDNGTRTKDLGGSAGTFQMADA 324 Query: 355 ICKIILR 361 + +++ Sbjct: 325 VVVELVK 331 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 94/360 (26%), Positives = 145/360 (40%), Gaps = 30/360 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M I + GDGI +E+ V A F + F ++ S E G + D+ Sbjct: 6 MNRYSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDL-SDESREAKGDAIYDE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + R+ P + R + V RPV PG+ Sbjct: 61 AEAAMRRYGTSLK--------YPTATTKESPNRVLRERCNFAVIHRPVATIPGIQTHYN- 111 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 I +VR T G Y G R+N + + RR R+AF LAQ R Sbjct: 112 ---ERIHLDIVRIATGGTYEDAGRRINR----DTAVSIRAIERRPSVLASRFAFRLAQLR 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + + +K + + E +A +YP + ++ D L A +M+PER+ V+V Sbjct: 165 D-SNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTF---PSLFEPVHGSAPDIYGKNIANPI 298 N +GD LSD+ G+IG+ SA+ + + ++F+P G+APDI G+N ANP Sbjct: 224 CPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPT 283 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A + A A ML +G D + A+ I G KT D+ G+ + I Sbjct: 284 AALLAMANMLRHIGEHDS-----SKALRGALFGAIEAGEKTADIGGSLNLSEFTQVIVDR 338 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 125/337 (37%), Positives = 169/337 (50%), Gaps = 52/337 (15%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IAAI GDGIG EV+ G + A ++ W + S Sbjct: 16 YKIAAIRGDGIGPEVIEAG---------NYQSAEETNRVAWILLNWPSRT---------- 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLR------PVRLFPGVPCP 118 GAV D + S + F Y+ LR P R+F G+ P Sbjct: 57 --------LSGAVRITRNTADISPISSSTFLW---FSSYLPLRSSTSNMPTRVFHGIQSP 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D+ +VREN+EGEY+ GGR G EV S+FTR GV+RI+++AFE A Sbjct: 106 L------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAA 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVE-AMAENYPEIRWDKQHIDILCARFVMQPERF 237 +SR +K +T ATKSN + WDE +A +P++ DK +D + AR V+ PE Sbjct: 160 RSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPESL 219 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +NL ILSDL A G+IGIAP++NL+P R PS+FEPVHGSA DI GK++A Sbjct: 220 DTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA-- 277 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 T W A ML +LG A +L +E V Sbjct: 278 --TFWTVAEMLSWLGQKG-----AAAELLECVESVCK 307 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 256 bits (654), Expect = 1e-66, Method: Composition-based stats. Identities = 91/457 (19%), Positives = 152/457 (33%), Gaps = 119/457 (26%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKM--MPDDW 62 + I GDG G ++ P +VL AA + + + A E +G +P D Sbjct: 29 VPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQYLPQDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + P + + R+ FD Y +RP R + G P P Sbjct: 89 LTAIKEYGIAIKGPLTTPI----GGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKS- 143 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + + I Sbjct: 144 -PDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIPLDAGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA------ 210 +R G R++R A + A P++ +T K N + + + + +A Sbjct: 203 IKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELATQEFRA 262 Query: 211 --------------ENYPEIRWDK--QHIDILC--------ARFVMQPERF--------- 237 E P+I ++ + ID A+ V + E Sbjct: 263 ECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTPEKKAQIVKEVETVINSIWSTHG 322 Query: 238 ------DVVVASNLFGDILSDL-----------------------GPACTGTIGIAPSAN 268 V+V + I + A G +G+ P AN Sbjct: 323 DGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGAN 382 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + ++FE HG+AP G + NP + I +G MML+++G +Q+A + I Sbjct: 383 IGDS---CAIFEATHGTAPKHAGLDKINPGSVILSGVMMLEYMG-----WQEAADLIKRG 434 Query: 329 IEEVIAHGPKTPDMKG-------NATTPQVADAICKI 358 + IA G T D+ + AD I + Sbjct: 435 LGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 255 bits (652), Expect = 2e-66, Method: Composition-based stats. Identities = 110/346 (31%), Positives = 171/346 (49%), Gaps = 47/346 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A IPGDGIG+E++P AAA ++F + S E Y G ++ DD E+L Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDI-SSERYIKTGIIIKDDELEEL 57 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + AI FGA+G P P I G +L+ RRE + Y+N+RPVR F Sbjct: 58 KNYRAILFGAIGDPRVRP-GIMEQGVILRLRRELELYMNIRPVRSFD-----------DK 105 Query: 127 IDFYVVRENTEGEYSSLGG---------------RVNEGTEHEVVIQESVFTRRGVDRIL 171 I ++RENT+ Y+ + G ++ + EV + + R + + Sbjct: 106 IKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFF 165 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 AF + T+T K+N + + W A I ++ D L + Sbjct: 166 NKAFSIC----DSTVTVTDKANAVKMYN-LWRSTAMEAAIE-KNINISFEYADALAYNMI 219 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + P+++ ++A NL+GDI+SD+G A G +G APSAN+ + +LFEPVHGSAPDI G Sbjct: 220 LNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDK---NALFEPVHGSAPDIAG 276 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 +++ANP A+I AG+M+L++LG DE I + + +G Sbjct: 277 RDMANPAASIMAGSMLLEYLGYRDE-----SRIINDMVRNLYINGV 317 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 92/362 (25%), Positives = 147/362 (40%), Gaps = 17/362 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 T I + GD G+E+L + +RVLQ + R L F + S E + + Sbjct: 4 TTPTIVVMHGDQTGEELLIQALRVLQPSVIR--QPLQFLDYDL-SLENRRATDNKVVWEA 60 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A P+ D R + V LR R P + P+AG Sbjct: 61 AQAARDSGLSLKAATITPEIAGDVG---SPNAILREALNAKVILRTGRRIPKI-RPIAGV 116 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +VR + Y S R E+ + S +R + + F+ A R Sbjct: 117 YSP---IAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFTFQYA-KRT 172 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 + + K A + E ++A A+ YPE+ + ID A + V+ A Sbjct: 173 KAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTGESLVIPA 232 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPI 298 N GD+LSD+ G+I + S L ++ + E HG+AP ++GKNIANP+ Sbjct: 233 LNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPM 292 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A I AGA +L + + ++A I ++ E I G TPD+ G TT + D + + Sbjct: 293 AMILAGAALLSY--GRIPQAEKASRAIYESVFETIYEGKATPDLGGQMTTSEFTDEVIRR 350 Query: 359 IL 360 + Sbjct: 351 VE 352 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 251 bits (641), Expect = 3e-65, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 145/370 (39%), Gaps = 34/370 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +R+ I G G G VL ++ +AA + ++ + + + + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAAL----VPVEWDYQTLSVYRDHKTNRMTVNPQL 94 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + P SL L + + +V +R G + Sbjct: 95 LDSAIETGLVLCAKDSSPRQND---SLESDSLALHKALNAFVGVRKFNSVVG------HE 145 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 G I+ +RE+ GEYS + V+ G VV +++ + + AF+ A Sbjct: 146 PYGPINLVNIREHVSGEYSEIEHLVSPG----VVQSIKTVSKKISVEVAKLAFDYACKHG 201 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +T K++ + +S + + ++ YP++ ++++ +D C P R++V++ Sbjct: 202 HSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRYEVLLT 261 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP------VHGSAPDIYGK---- 292 ++L+G + +G + P+ P+ T S H I+ K Sbjct: 262 TSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYG 321 Query: 293 --NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 I NP I A A+MLD G A I AA+E+ I G +T DM G+A+ Q Sbjct: 322 QEQIINPTGIIRAAALMLDHAG-----MVVAGRCIAAAVEDTIRQGIRTQDMGGDASCSQ 376 Query: 351 VADAICKIIL 360 DAI K + Sbjct: 377 FTDAIIKNLK 386 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 246 bits (629), Expect = 8e-64, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 148/342 (43%), Gaps = 37/342 (10%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + V+ A + ++ + E+ + + + + L G V Sbjct: 1 MDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS 52 Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 + R++F Q+ + G+ P GD D ++R+ EG+ Sbjct: 53 RHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGD 97 Query: 140 YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 YS + V G V+ V T G RI + F A RK +T A K+N + ++ Sbjct: 98 YSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTD 153 Query: 200 PYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + E + A A+ + ++ ++++++D + +++P + DV+V+S+++GD+L + Sbjct: 154 GNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMM 213 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G GI P +++ + ++F+ + + GK++ANP + + A+ML + + Sbjct: 214 GVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHV-----KM 265 Query: 319 QQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + + + AI +V +TPD+ G A + A+C + Sbjct: 266 DKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 243 bits (620), Expect = 8e-63, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 143/327 (43%), Gaps = 35/327 (10%) Query: 19 VLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVG 78 ++ ++V + ++ + S G+ + E L R G Sbjct: 1 MIESLVKVFSTVQ----VPIDWDVFH--EHKINSAEGEDVSPKLLESLCRNKIGIKGPFE 54 Query: 79 WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEG 138 L K R++F + + R G + G +D ++R+ EG Sbjct: 55 SGPC----------LRKLRKKFQLFAFVAVCRNLEG-----QNTRYGKLDCLIIRDQVEG 99 Query: 139 EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAIS 198 EYS + RV G V+ V T G DR+ RY FE A+ RK +T A K+N + ++ Sbjct: 100 EYSGIEHRVVPG----VMQTIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLT 155 Query: 199 MPYWDERVEAMAENYP-EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + + A Y +I ++++++D +C +M+PER DV+VAS+++GD+L+ + + Sbjct: 156 DGTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASI 215 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDER 317 G + P + P ++EP+ + +I GK+I NP + +G +ML + + Sbjct: 216 MGGPALCPGFAVGPMGL---IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLR-----EMK 267 Query: 318 FQQAHNGILAAIEEVIAH-GPKTPDMK 343 + + I A+ V +T D+ Sbjct: 268 LNEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 152/365 (41%), Gaps = 17/365 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++I + GD G+E+L + +RVL E G L E+ + S E + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDL-SLENRRATQNGVVS 57 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D + A P+ D R E D V +R R PGV P+A Sbjct: 58 DAAAAMRTCGFGIKAATITPEGADDVG---SPNRILREEVDGKVIVRTGRRIPGV-TPIA 113 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +VR E Y + R + G EV + TR + YAF A+ Sbjct: 114 GVHYP---ISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEYAFRTAR 170 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QPERFD 238 + + K + E ++A A +P++ ++ ID A V + Sbjct: 171 AMQ-ARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGAADEPL 229 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNIA 295 VV A N GD LSDL G+I A S L + T ++ E HG+AP + GK++A Sbjct: 230 VVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVA 289 Query: 296 NPIATIWAGAMMLDFLGNG-DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NP+A + A +L ++A I ++ E IA G KTPD+ G+A T + DA Sbjct: 290 NPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTDA 349 Query: 355 ICKII 359 + + I Sbjct: 350 VIERI 354 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 236 bits (602), Expect = 1e-60, Method: Composition-based stats. Identities = 75/355 (21%), Positives = 130/355 (36%), Gaps = 23/355 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + ++A +PGDG G + R L R + + ++ + G +P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---PCP 118 + DA+ G P I LL R+E + VN+RPVR Sbjct: 68 TLGACRQSDAVLVCGCGDPRY---GIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + +D R+ T G Y + E + ++R+ ++RI R A A Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGE---AYDTTPYSRQTIERIARLAGTYA 181 Query: 179 QS-RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 P K + S K N +A S + +P++ +D P Sbjct: 182 MQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDPLSL 241 Query: 238 D-VVVASNLFGDILSDLGPACTGTIGIAPSANL-----NPERTFPSLFEPVHGSAPDIYG 291 + +++ N+FGDILSD G+ + SA + R P +FEP + + G Sbjct: 242 NGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNP----G 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE--EVIAHGPKTPDMKG 344 P+ +I A +ML+ + I ++ E++ +T D+ G Sbjct: 298 GKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 230 bits (588), Expect = 5e-59, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 145/342 (42%), Gaps = 45/342 (13%) Query: 18 EVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAV 77 E+ + LQ A G ++++ ++ ++P+ + + G + Sbjct: 12 ELGAQVTNALQMAIAATGVDITWQIVDIGG----EDQQGLLPNYIFDIIRTAKTAVIGPL 67 Query: 78 GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE 137 PD + R + D YVNLRP + G+P ++D +VRE TE Sbjct: 68 MMPD------NYRQMEADIREKLDLYVNLRPAKTMVGIPSNY-----QNVDIMIVRETTE 116 Query: 138 GEYSSLGGR----------------VNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G Y+ + + + + + +G +I+ +AF A+ Sbjct: 117 GIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKT 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R + + +++ +A + + E +A+ +P+I + + I+++C + +PERFDV+V Sbjct: 177 KRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GD+L+ L G + + P A++ + + D G + P + I Sbjct: 237 MPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVFG----AQSTGTDDVGHD---PTSLI 288 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM 342 AGA+ML LG Q+A + AA+E V+A T D+ Sbjct: 289 LAGALMLRHLGE-----QEAAQRLQAAVEAVVASHVDTTADL 325 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 97/364 (26%), Positives = 146/364 (40%), Gaps = 31/364 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +R+A +PGDG+G+EVL R+L+ AER ++ + G ++P Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTGPWP--VGARAAAETGDVLPAGTLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDH--ISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI GAVG VP +L + R +D +++R + G Sbjct: 60 ACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGRE------ 113 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 VVR G Y RV E TR V ++ A ++ R Sbjct: 114 ------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLGRRG 166 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L S K+N L + W + +A I + +++D DV+V Sbjct: 167 GGRLVSVDKAN-LYATGRLWRQVAGDVARE-RGIEVEHRYVDRAAFELGSGAPVPDVLVT 224 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGKNIANPI 298 L GDILSDL G+ + SA+L+P LFEP HGSAP ++ +P+ Sbjct: 225 EGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPL 284 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 A A +L ++A + AA+ V+ GP T D+ A+T QVADA Sbjct: 285 GGFLALAALLRHF----PATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVADA 340 Query: 355 ICKI 358 + Sbjct: 341 VLAA 344 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 229 bits (584), Expect = 1e-58, Method: Composition-based stats. Identities = 106/351 (30%), Positives = 159/351 (45%), Gaps = 21/351 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T R+ G+GIG E++ ++ ++ A + G A E + G+++P++ Sbjct: 5 ETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEET 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E ++ D G P R++ D + N+RPVR PG P Sbjct: 65 WETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP---- 120 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQ 179 D+D +VRENTEG Y+ + G EV + VFT+ + + Sbjct: 121 ---DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIR-RIVRRAAAIA 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + LT A KSN L + + +A AE + + HID LCA V +PER+ Sbjct: 177 AARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTRPERYAT 235 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +VA N+FGDILSDL G++GIA S N + + + + HGSAPDI G+ IANP Sbjct: 236 IVAENMFGDILSDLAGGLGGSLGIAGSINASESQ---VMAQAAHGSAPDIAGQGIANPAG 292 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 + + A MLD LG QA + A+ E + P T D+ A Sbjct: 293 IMNSAAQMLDSLGY-----PQAAELLEGAVREAVVKAP-TADLVREAAAAD 337 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 91/255 (35%), Positives = 126/255 (49%), Gaps = 19/255 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG E++ + VL+AAA R L F + A + + G M E++ Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSED-AGADAFRRTGSAMSAATLERI 66 Query: 67 S-RFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 R+ + G VG P PD R D Y N+RP+ L PGV PL G Sbjct: 67 RTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTA- 125 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESV-FTRRGVDRILRYAFELAQSR-- 181 +D+ +VRENTEG Y S G G ++ + + TR GV+R++ +AFELA R Sbjct: 126 --VDYVIVRENTEGLYLSRG----RGVGNDRACADQLLMTRHGVERVVVHAFELATRRTG 179 Query: 182 ----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + +T KSN L S ++ E + +A YP++ D ++ D V P RF Sbjct: 180 APADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRF 238 Query: 238 DVVVASNLFGDILSD 252 DV+V N GDILSD Sbjct: 239 DVLVMENFLGDILSD 253 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 210 bits (536), Expect = 4e-53, Method: Composition-based stats. Identities = 68/378 (17%), Positives = 130/378 (34%), Gaps = 44/378 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 + I I GDGIG E+ I V+ +A E G E Y G +P Sbjct: 21 PDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVP 80 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 +D +++ + + +PD R+ Y N+R ++ G+ P+ Sbjct: 81 EDSIKEIQKMYIAMK---STLNFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMDIPV 134 Query: 120 AGKQPGDIDFYVVR-------------ENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRG 166 ++ ++R E+T+ + + I ++ Sbjct: 135 N--TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFR 192 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +I + A ++ +K +T + + A ++ ++ Sbjct: 193 TRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEASAQEDVGYEVLKTREF 247 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 R + PE F+V++ N+ L D GTI I +++ E ++FE V S Sbjct: 248 MKRLISSPEDFEVILVDNVLSQTLVDYLA---GTINIEYGSSIGDE---CAVFEAVQSSL 301 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK--- 343 P G + A+P++ I +G ML +G + +A I AI D+ Sbjct: 302 PSEAGYDAADPLSFILSGCEMLMHIG-----WVEAAQIIENAISAAFRDNKIPKDINTRP 356 Query: 344 --GNATTPQVADAICKII 359 + + I K + Sbjct: 357 DISPIKCSEFSSEIIKRM 374 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 200 bits (509), Expect = 6e-50, Method: Composition-based stats. Identities = 69/361 (19%), Positives = 126/361 (34%), Gaps = 68/361 (18%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + + I V +V+ A + FE + + Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQA----PVYFETYIIKG-----KNMNHLTW 44 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + + + G V R+E D + +L G P Sbjct: 45 EVVDSIRKNKVCLNGRVNNSLCGGA-----------RKELDLFASLVDCFNLNGQPS--- 90 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + ++D V+RENTEGEY+ V G + T+ DRI +YAFE A Sbjct: 91 --RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVTM---TKFWSDRIAKYAFEYAHF 145 Query: 181 RPRKTLTSATKSNGL-AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 RK +T+ + ++ ++ E + +A+ YP I +++ +R R Sbjct: 146 SKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEI-----ASRETRAIRRHS- 199 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 S I++++ G + + ++FE V N NP+A Sbjct: 200 --NSKSLWAIIANIASGVAGG-------SFGDDY---AIFEQVGSVG------NHKNPVA 241 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +++ MML L + + A+ VI+ G N TT +V D++ + Sbjct: 242 LLFSSVMMLRHLL-----LPLFADRLKTAVTRVISEGKCG---NSNTTTQEVVDSVIANL 293 Query: 360 L 360 Sbjct: 294 D 294 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 196 bits (499), Expect = 9e-49, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 89/165 (53%), Gaps = 9/165 (5%) Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 +S + V MA+ +PEI+++++++D +C V P ++DV+V NL+GDILSD+ Sbjct: 112 RMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 171 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 G +G+ PS N+ +LFE VHG+APDI GK++ANP A + + MML + Sbjct: 172 GLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM---- 224 Query: 316 ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + I A E I G T D+ G A + + IC + Sbjct: 225 -ELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 268 Score = 49.2 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 21/42 (50%), Gaps = 4/42 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW 45 T ++ IPGDGIG E+ ++ AA + +E ++ Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDV 84 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 195 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 64/416 (15%), Positives = 120/416 (28%), Gaps = 67/416 (16%) Query: 3 KTMRIA--AIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++A + D G E+ + ++ + + + + Sbjct: 42 KRIKVAKPVVEMD--GDEMTRIIWQFIKEKLILPHVDIQLKYFDL-GLPNRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D ++ A PD R V P+ + + Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPI-ICKNI 157 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEY----------------------SSLGGRVNEGTEH 153 P + G + R +Y S + Sbjct: 158 PRLVPGWTKP---ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA 214 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 V T + F+ A + L +TK+ L + + + + ++ Sbjct: 215 GGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEIFDKH 273 Query: 213 YP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y +I ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 274 YKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTS 332 Query: 267 ANLNPERTFPSLFEPVHGSAPDIY---GKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K NPIA+I+A L+ G D + Sbjct: 333 VLVCPDGKTI-EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 391 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGN-------------ATTPQVADAICKIILR 361 + + E + G T D+ G T D I + R Sbjct: 392 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDR 447 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 66/418 (15%), Positives = 128/418 (30%), Gaps = 70/418 (16%) Query: 1 MMKTMR---IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M K + + + GD E+ +++ L + E Sbjct: 1 MSKKISGGSVVEMQGD----EMTRIIWELIKEKLIFPYVELDLHSYDL-GIENRDATNDQ 55 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLF 112 + D E + + + A PD R V R + Sbjct: 56 VTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVF-REAIIC 114 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR------- 165 +P ++G + R +Y + V + E+ S T++ Sbjct: 115 KNIPRLVSGWVKP---IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHN 171 Query: 166 ----------------GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 ++ +F++A S+ L +TK+ L + + + + Sbjct: 172 FEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEI 230 Query: 210 -AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + Y +I ++ + ID + A+ + F + N GD+ SD G++G Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLG 289 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ + NPIA+I+A L D Sbjct: 290 MMTSVLVCPDGK-TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDN 348 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMKG------------NATTPQVADAICKIIL 360 + N + E I G T D+ T + D + + + Sbjct: 349 NKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 111/301 (36%), Gaps = 19/301 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E ++++ +K + D Y+ VR FPG Sbjct: 93 DPLETDDFYNSVLRNRSAVHVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGF----- 147 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + D++ ++ +N G YS L +G VV SV T+ G ++ LR AF A Sbjct: 148 NCRFPDVNIRIIAQNNMGVYSDLEYSPVKG----VVEAISVSTQEGNEKYLRKAFATAVK 203 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDV 239 RK +T KS I+ + + ++Y + + +++ R + P+ FD Sbjct: 204 ANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHCLELELMNVEDCIGRLITHPQEFDC 263 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + +S+ + +++ + G + + + ++F+P+ + I +P Sbjct: 264 IFSSDRYATMIATMCSGICGGANLFSAVEIGDFH---AVFKPLQ-VKLSLTNYPILSPYG 319 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + D LG + + + + + G KT D G + V I + Sbjct: 320 IVNTIVDLFDHLGYT-----ECGDALWEQMLRTMESGIKTKDFGGEDSGEYVICNIINRL 374 Query: 360 L 360 Sbjct: 375 R 375 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 189 bits (481), Expect = 1e-46, Method: Composition-based stats. Identities = 67/414 (16%), Positives = 132/414 (31%), Gaps = 65/414 (15%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 + +++ + D G E+ +++ + + S ++ + Sbjct: 180 QRIKVDQPVVEMD--GDEMARVIWAMIKEKLILPYLDIPLMYYDL-SIQHRDKTDDQVTI 236 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D + R A PD R D + P+ L V Sbjct: 237 DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPI-LMKNV 295 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE---------------HEV----- 155 P + + R +Y +L V++ HEV Sbjct: 296 PRLVPSWTKP---IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKG 352 Query: 156 -VIQESVF-TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 + ++ T + F+ A + + L +TK+ L + + + + + Sbjct: 353 GGVALGMYNTDASIKGFAHSCFQYALDQ-KMPLYLSTKNTVLKKYDGRFKDIFQTIYEKE 411 Query: 213 YPE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y + + ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 412 YKQKFEEAGLWYEHRLIDDMVAQAIKSSGGF-VWACKNYDGDVQSDVVAQGYGSLGLMTS 470 Query: 267 ANLNPERTFPSLFEPVHGSAPDI---YGKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K I NPIA+I+A L D ++ Sbjct: 471 VLVCPDGKTI-EAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKL 529 Query: 319 QQAHNGILAAIEEVIAHGPKTPDM-----KGNAT------TPQVADAICKIILR 361 ++ + A E + G T D+ T T D + ++ R Sbjct: 530 KEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRDYLCTEDFMDKLARVAER 583 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 185 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 68/418 (16%), Positives = 123/418 (29%), Gaps = 69/418 (16%) Query: 2 MKTMRIAA----IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M +I + D G E+ + ++ L + + Sbjct: 1 MAFQKITVQNPIVEMD--GDEMTRVIWKSIKDKLILPFLELDIKYFSL-GLPHRDATDDK 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPV--- 109 + + E +++ A PD R + V P+ Sbjct: 58 VTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCK 117 Query: 110 ---RLFPGVPCPLAGKQP----------------GDIDFYVVRENTEGEYSSLGGRVNEG 150 RL PG P+ + G + V E + E + G Sbjct: 118 NIPRLVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGS-DEKTEFEVYNFTG 176 Query: 151 TEHEVVIQESVFTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 + S++ R + +A + L +TK+ L + + + + Sbjct: 177 AG---GVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKDIFQEV 232 Query: 210 AE-------NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 E I ++ + ID + A + + V N GD+ SD G++G Sbjct: 233 YEANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLG 291 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY------GKNIANPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ N IA+I+A L D Sbjct: 292 LMTSVLVCPDGKTI-EAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDN 350 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMK-----GN-------ATTPQVADAICKIIL 360 ER + AA + G T D+ G+ T + DA+ + Sbjct: 351 NERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELK 408 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 75/372 (20%), Positives = 139/372 (37%), Gaps = 36/372 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS----HHGKM 57 M ++++ G+G G E+ RV+Q+ A R+ +++F + Y S + Sbjct: 1 MSSIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADA 60 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 + ++ + + AV S+ L RE Q + + L P Sbjct: 61 VTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQAIKVEHFTLSPTSS- 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 +VR+ +G YS + T + V + + F++ RIL YA Sbjct: 120 -----------ILLVRDQAQGFYSG---TNSVNTSKDAVSRTAHFSKAIFARILSYALGR 165 Query: 178 AQSR--PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QP 234 A ++T K + + + + D + + Sbjct: 166 ANQLWGGTNSVTMVYKFHLF---DGLFHTWATEWERTF-GVNIRFVQGDTMNRDLLAFGV 221 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSA-----NLNPERTFPSLFEPVHGSAPDI 289 +++++ N + DI+ + G +G SA L+P+ S ++ HGSA D+ Sbjct: 222 SGHNLLISGNEYADIMQTILLDRFG-LGAQESACAENVYLHPDVQGLSEYQTAHGSADDL 280 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 GK I NP ATI A A +L+ + + ++ A G TPD G ATT Sbjct: 281 LGKGIVNPTATIRAAAAVLEDQAGCSG----LKQRVDCVLGDLGARGIGTPDQGGTATTE 336 Query: 350 QVADAICKIILR 361 + +A + + + Sbjct: 337 RFVEAFLQGLDQ 348 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 62/366 (16%), Positives = 115/366 (31%), Gaps = 59/366 (16%) Query: 47 SCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFD 101 EY + + E + ++ A PD R Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160 Query: 102 QYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ--- 158 V P+ + P +P + G + R +Y + + + E+V Sbjct: 161 GTVFREPI-VIPAIPRLVPGWTKP---IIIGRHAFGDQYRATDRVIPGPGKLELVYTPAN 216 Query: 159 -------------------ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 T + +F++A + L +TK+ L Sbjct: 217 GQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNTILKRYD 275 Query: 200 PYWDERVEAM-AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSD 252 + + + + Y I ++ + ID + A+ + F ++ N GD+ SD Sbjct: 276 GRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMALKNYDGDVQSD 334 Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAM 306 + G++G+ S P+ + E HG+ Y G+ + NPIA+I+A Sbjct: 335 IVAQGFGSLGLMTSTLTTPDGSAFES-EAAHGTVTRHYREHQKGRETSTNPIASIFAWTR 393 Query: 307 MLDFLGNGD--ERFQQAHNGILAAIEEVI-AHGPKTPDMK---GN------ATTPQVADA 354 L G D + A EV+ G T D+ G TT + A Sbjct: 394 GLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKEREAWVTTREYMAA 453 Query: 355 ICKIIL 360 + + + Sbjct: 454 VERRLK 459 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 108/286 (37%), Gaps = 26/286 (9%) Query: 81 DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEY 140 D P LLK R+E Y ++RP L Q + + + Sbjct: 35 DGAPATSRPERGLLKLRKEMGTYGSMRPCFFASD---SLVAPQGRGVPRHRLCHCARAHR 91 Query: 141 SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 L R G+ ++ V+R A L + R K L S +N LA S Sbjct: 92 RYLLWRAQTGSGS--AWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSRF 149 Query: 201 YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVASNLFGDILSDLGPACTG 259 + E + +P+++ + Q I+ V P + VVV S LFGDI+SD Sbjct: 150 WRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPD 209 Query: 260 TIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 +IG+ PSA+L + R ++EP+H + + A+ + + Sbjct: 210 SIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC----------- 256 Query: 316 ERFQQAHNGILAAIEE--VIAHGPKTPDMKGNATTPQVADAICKII 359 + + + ++ V +T ++ G A T ++ +A+ + Sbjct: 257 -PWPCFSDTLSTSLRRLWVPPWSLRTKELGGGANTKELGEAVINEV 301 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 66/386 (17%), Positives = 130/386 (33%), Gaps = 50/386 (12%) Query: 2 MKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M +++ + D G E+ +V++ + + + EY + Sbjct: 7 MNKIKVKNPVVELD--GDEMTRIIWQVIKDKFIHPYLDIDLKYYDL-GLEYRDETNDQVT 63 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPG 114 D E + ++ A PD R V P+ + P Sbjct: 64 LDAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPA 122 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 +P + + + R +Y + ++ E+V + V ++ + Sbjct: 123 IPRLVPSWKQP---IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKG-GKPEVIKVYDFP 178 Query: 175 FE--LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 E +AQ++ K I + + EA I ++ + ID + A+ + Sbjct: 179 AEGGVAQTQF--------KDIFQEIYEAQYRKEFEA-----AGIWYEHRLIDDMVAQMIK 225 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-- 290 + ++ N GD+ SD+ G++G+ S + P+ E HG+ Y Sbjct: 226 SEGGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTF-EAEAAHGTVTRHYRE 283 Query: 291 ---GKNIA-NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAA-IEEVIAHGPKTPDMK 343 G+ + NPIA+I+A L G D + A ++ V G T D+ Sbjct: 284 HQKGRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLA 343 Query: 344 ---GN------ATTPQVADAICKIIL 360 G TT + DA+ + + Sbjct: 344 LAQGKKDRSAWVTTNEYLDAVERRLK 369 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 180 bits (458), Expect = 5e-44, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 106/269 (39%), Gaps = 19/269 (7%) Query: 93 LLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE 152 LK + D YV + +R FPG C + D+D V+ +N G YS L +G Sbjct: 134 SLKICNDLDLYVFMTRLRSFPGFKC-----RFPDVDIQVIAQNNIGNYSELEYAPVKG-- 186 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AE 211 VV V T V + LR+AFE A R +T K+N ++ E E M AE Sbjct: 187 --VVEALRVVTHENVTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAE 244 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 +Y I+ + +D R + P FD + ++ + L+ + G + + L Sbjct: 245 DYCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIELGD 304 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 ++F+P+ + + ++ +P + +L+ +G + + Sbjct: 305 SH---AVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQES-----CAKSLWKGMLR 355 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKIIL 360 + G KT + G T V I + Sbjct: 356 TMTDGIKTVEFDGPDTGEYVICNIMNKLR 384 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 171 bits (433), Expect = 4e-41, Method: Composition-based stats. Identities = 68/412 (16%), Positives = 117/412 (28%), Gaps = 75/412 (18%) Query: 16 GKEVLPEGIRVL--QAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIY 73 G+E+ ++L Q + + S+E + SC+ D E R AI+ Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDIS-SWETFDL-SCKARDDSDDATLIDAVEAGKRIGAIF 146 Query: 74 FGAVGWP-----DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDID 128 P + + RR ++ R G+ + Sbjct: 147 KEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQ------ 200 Query: 129 FYVVRENTEGEYSSLGGRVNEGT----------EHEVVIQESVFTRR------------G 166 R GEY + V EGT V+ + T + Sbjct: 201 VLFERHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPYDN 260 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI---------- 216 V + F+ TK +W + Y + Sbjct: 261 VRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFWATMKRVFDDTYKDEFLKAGLLDRS 319 Query: 217 --RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERT 274 D + + + + A N GD+L+D + G S + Sbjct: 320 GGELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGVSDD 379 Query: 275 FPSL---FEPVHGSAPD-----IYGKNIA-NPIATIWA--GAMM----LDFLGNGDERFQ 319 +L FE HG+ D + GK + NP+ + A GAM L++ ++ Sbjct: 380 GTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLEYDAKPNDVEA 439 Query: 320 Q--------AHNGILAAIEEVIAHGPKTPDMKGNA--TTPQVADAICKIILR 361 + N + A+ +G T DM G TT + + R Sbjct: 440 KRMYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTGFTTEDFIAKVAWRLDR 491 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 171 bits (433), Expect = 4e-41, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 81/234 (34%), Gaps = 36/234 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEW-ASCEYYSHHGKM--MPDDW 62 I I GDG G ++ P V+ AA A+ +G + A E +G P+D Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + P + + R+ FD Y +RP R +PG P P Sbjct: 89 LTAIKEYGVAIKGPLTT----PVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + I Sbjct: 143 TPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRLDSGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA 210 ++ G R++R A A+ P+ +T K N + + + + +A Sbjct: 203 IKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELA 256 Score = 139 bits (351), Expect = 1e-31, Method: Composition-based stats. Identities = 44/170 (25%), Positives = 72/170 (42%), Gaps = 26/170 (15%) Query: 197 ISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 W E ++ + + D + + +P+ + ++ NL GD LSD A Sbjct: 321 HGNGQWKE----------KVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAA 370 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G +G+ P AN+ ++FE HG+AP G + NP + I +G MML+F+G Sbjct: 371 VVGGLGMGPGANIGDS---AAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMG---- 423 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKI 358 +Q+A + I I IA+ T D+ + A AI Sbjct: 424 -WQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 170 bits (431), Expect = 7e-41, Method: Composition-based stats. Identities = 64/400 (16%), Positives = 116/400 (29%), Gaps = 64/400 (16%) Query: 16 GKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYF 74 G+E+ + +++A E ++ + + + +++ D E AI+ Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTAWREFDLRAKNRDDTEDQVLRD-VIEAGKAVKAIFK 76 Query: 75 GAVGWP-----DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDF 129 P + S RR ++ R GV + Sbjct: 77 EPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE--- 133 Query: 130 YVVRENTEGEYSSLGGRVNEGT-------------EHEVVIQESVFTRRG---------- 166 R GEY++ V +GT V + T Sbjct: 134 ---RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNPY 190 Query: 167 --VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP---------- 214 V + R+ F TK P+W + E Y Sbjct: 191 DNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFWQIMKKVFDEEYKSKFVDAGVMK 249 Query: 215 -EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPER 273 D + V + + A N GD+L+D + G S + + Sbjct: 250 SGDELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGFITSNLVGVDE 309 Query: 274 TFPSL--FEPVHGSAPD-----IYGKNIA-NPIATIWAGAMMLDFLGNGD----ERFQQA 321 + FE HG+ D + G+ + NP+ + ++ + ER Sbjct: 310 NGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNVDKERTLAF 369 Query: 322 HNGILAAIEEVIAHGPKTPDMKGN--ATTPQVADAICKII 359 + A I ++ G T D+ G TT Q DA+ + + Sbjct: 370 TAKMRAVIHQLFREGKGTRDLSGPSGLTTEQFVDAVAERL 409 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 67/406 (16%), Positives = 119/406 (29%), Gaps = 60/406 (14%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 M + D G E+ ++++ L E + + + D Sbjct: 37 QMTTPLVEMD--GDEMTRIMWQMIKDELICPFVDLKTEYYDL-GLAHRDETDDQVTVDSA 93 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 E R A P+ R D V P+ + PC Sbjct: 94 EATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPIVVRGIDPCV 153 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ----------ESVFTRRG-- 166 +P + R Y R+ E+V FT G Sbjct: 154 KNWVRP----ITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGVV 209 Query: 167 ---------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-----AEN 212 ++ R F+ A + + + ATK + + + + A Sbjct: 210 EGMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAAR 268 Query: 213 YP--EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN 270 + I + ID AR + F + N GD++SD+ + G++ + S + Sbjct: 269 FEAAGIEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAMMTSVLAS 327 Query: 271 PERTFPSLFEPVHGSAPDIYGKNIA------NPIATIWAGAMMLDFLGNGD--ERFQQAH 322 P + +E HG+ Y K++A N +ATI+A L D Sbjct: 328 PHGYW--EYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLADLAAFA 385 Query: 323 NGILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKIIL 360 + + A I G T D+ +T A+ + + Sbjct: 386 DALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDLK 431 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 72/378 (19%), Positives = 133/378 (35%), Gaps = 43/378 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY--------SH 53 ++T+R+ G G G+E++ RV+Q A+++ F + Y+ + Sbjct: 3 IQTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVRSSSTYHSYHTLTVSGEDKN 62 Query: 54 HGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + D+ + + A G ++ L R+ Q + L Sbjct: 63 LITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYLVRQHLQAAKVEHFSLGD 122 Query: 114 GVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 G +VR+ +G Y+ + + + + F++ DRI+R+ Sbjct: 123 GNA------------LLMVRDEAQGFYAG---DNTYSADQLSITRTTSFSKPVFDRIIRF 167 Query: 174 AFELAQSR-----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 A + A K +T A K + + + I +D D L Sbjct: 168 ALDRAAENWGPENVPKKVTMAYKFHLF---DGVFQAWEPQWKAQF-GIDFDFIQPDTLNR 223 Query: 229 RFVMQ-PERFDVVVASNLFGDILSDLGPACTGTIG----IAPSANLNPERTFPSLFEPVH 283 + + +++A N + D++ + G A + L P+ S ++ VH Sbjct: 224 SLMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETMYAENVYLRPDVNGLSEYQTVH 283 Query: 284 GSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 GSA I K + NP ATI A A +L G AI+ ++ TPD Sbjct: 284 GSADAIADKGLVNPFATIRAAAAILERHAGGKG-----IQKLTEQAIQSLLQRKLTTPDQ 338 Query: 343 KGNATTPQVADAICKIIL 360 G+ T + D + I Sbjct: 339 GGSLKTEETVDHFLQAIA 356 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 163 bits (413), Expect = 8e-39, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 126/377 (33%), Gaps = 44/377 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M +RI G G G E+ V++ A R+ + F + + Y + + D+ Sbjct: 4 MDPLRIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRIYHSY---NSLPLADE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + + G + FR + V L Sbjct: 61 SQNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAIS-------AQSLYAVRQQLEA 113 Query: 122 KQPGDID-----FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 + D V+R+ +G Y+ ++ + V + F + I+ ++ E Sbjct: 114 VKVECFDRGTSSLLVIRDQAQGFYTG---TNKLESDQDSVSRVCHFRKGVFQHIIAFSLE 170 Query: 177 LAQSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ + K++ K + + + I+ + D + Sbjct: 171 RAREKWGYDLGGIKSVFLVYKFHLF---DGLLLSWARDWTKEF-GIKVEFIQPDTMNRNL 226 Query: 231 VMQPERFDVVVASNLFGDILSDLG----PACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 + +++A N + DI+ + + + L P S ++ HGSA Sbjct: 227 IAFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSEYQTTHGSA 286 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI----AHGPKTPDM 342 DI GK I NP ATI A A +L+ G I A +++ + + TPD Sbjct: 287 DDITGKGIVNPSATIRAAAAILERFGGCVG--------IDAKVDDTLNILQKNKSGTPDQ 338 Query: 343 KGNATTPQVADAICKII 359 GN TT D + + Sbjct: 339 GGNLTTAAFVDVFLRTL 355 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 163 bits (413), Expect = 9e-39, Method: Composition-based stats. Identities = 48/132 (36%), Positives = 67/132 (50%), Gaps = 8/132 (6%) Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P +FDV+V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGAN--GVAIFESVHGTAPDI 87 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATT 348 GK++ANP A + + MML +G I A + I T D+ GN Sbjct: 88 AGKDMANPTALLLSAVMMLRHMG-----LHGHAKKIETACFDTIRDKKVLTKDLGGNPKC 142 Query: 349 PQVADAICKIIL 360 + IC+ + Sbjct: 143 SEFTADICRRVQ 154 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 160 bits (404), Expect = 8e-38, Method: Composition-based stats. Identities = 60/408 (14%), Positives = 115/408 (28%), Gaps = 87/408 (21%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I + GD E+ R+++ L + + + + E Sbjct: 87 IVEMDGD----EMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNR-DATDDKVTVESAEAT 141 Query: 67 SRFDAIYFGAVGWPDTV-----PDHISLWGSLLKFRREFDQYVNLRPV------RLFPGV 115 +++ A PD R + V P+ R+ PG Sbjct: 142 LKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCLNIPRIVPGW 201 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSS-----------------------LGGRVNEGTE 152 P+ + R +Y + L V + Sbjct: 202 KKPIC----------IGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKG 251 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN 212 V + + + + LA + + L +TK+ L + + + + E Sbjct: 252 PGVALAMYNVDQS-IRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEE 309 Query: 213 -----YPE--IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 + E I ++ + ID + A V + V N GD+ SD + Sbjct: 310 KWKQKFEEHSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEA 361 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD--ERFQQAHN 323 A LF+ ++ N IA+I+A L+ D E + Sbjct: 362 EAAHGTVTRHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVH 413 Query: 324 GILAAIEEVIAHGPKTPDMK----GN-------ATTPQVADAICKIIL 360 + + E + G T D+ G T + DA+ + + Sbjct: 414 KLEGSCIETVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLE 461 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 147 bits (372), Expect = 5e-34, Method: Composition-based stats. Identities = 48/197 (24%), Positives = 82/197 (41%), Gaps = 29/197 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH---HGKMMPDDW 62 I I GDGIG ++ P I+V+ AA ++ +G ME + E + +P + Sbjct: 31 IPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQET 90 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + G + P + + R++ D YV LRPVR F GVP P+ Sbjct: 91 LDAVKDYVVSIKGPLTT----PVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVK-- 144 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVVIQESVFT 163 +PGD+D + REN+E Y+ + + + + I + Sbjct: 145 KPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGVKPVS 204 Query: 164 RRGVDRILRYAFELAQS 180 + G R+ R A A++ Sbjct: 205 KEGTKRLARKALHSAEA 221 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 142 bits (359), Expect = 2e-32, Method: Composition-based stats. Identities = 47/186 (25%), Positives = 76/186 (40%), Gaps = 16/186 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG E+ +++ AA + FE E A + Y G+++P+ +E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFET-ENAGSDVYEKTGELIPESLYES 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R G + P + R+++D Y N R R PG+ Sbjct: 58 VERNKIAIKGPITTPI----GKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY-----D 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +ID + RENTEG Y NE I T++G + +L+ + + + Sbjct: 109 NIDLAIFRENTEGIYIGEEKYENEEKTS--AIAVKRITKKGSEELLKVLLNMQRIMEFRK 166 Query: 186 LTSATK 191 L K Sbjct: 167 LQLFIK 172 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats. Identities = 66/374 (17%), Positives = 126/374 (33%), Gaps = 53/374 (14%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAE--RWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 I I GDG G E+ I + +A E G + + E Y +GK +P + Sbjct: 17 TIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGKYLPRESI 76 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP------- 116 E + + + G + +I+ + +R + Y +++ + PG+ Sbjct: 77 EDIRKTVFVMKGPLSS------NINGHDININIKRILNLYTDVKCITGLPGLSEGKEIFI 130 Query: 117 -CPLAGKQP------GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDR 169 P + D D R+ Y ++ G + ++ +R + + Sbjct: 131 FSPSIDEVYHFSYDSEDSDML--RQ-----YLQQSFNISIGGDSDIF--LKGTSRYRIIK 181 Query: 170 ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 I E++ K A G P W + + + + + Sbjct: 182 IASKIAEISSLYGIKRTLVADDYTGSHA--PLW--VYNTLNKMEMPVEIENLY---NLYD 234 Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 + RF++ + + ++ + A T A L F SLFE + Sbjct: 235 EMTSESRFNIFIPDSRLSSLIIKIINART-----FFGAILGD---FISLFESQSRPSFTE 286 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP--DMKGNAT 347 G ++A+P + + A +MML L F A + A+ V + G ++ Sbjct: 287 EGYDLADPTSFLLASSMMLRRL-----NFNDAALILRNALNSVYSDGILPASLNLNNGLK 341 Query: 348 TPQVADAICKIILR 361 DAI K + R Sbjct: 342 CSDFIDAIVKRMKR 355 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 139 bits (350), Expect = 2e-31, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 63/174 (36%), Gaps = 18/174 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + PG G+G E+ + AA + +++ + ++ D Sbjct: 31 QFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHID-VDNAKPGQDLISADAL 85 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P L R+ Y N+RP PGV P Sbjct: 86 DSLRRNRFGLKGPMATPI----GKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---- 137 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 D+D VRENTEGEYS L V G VV V T V+ ++ F + Sbjct: 138 -DDVDVVTVRENTEGEYSGLEHVVYPG----VVESLKVITPERVNARVQVPFSI 186 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 133 bits (335), Expect = 1e-29, Method: Composition-based stats. Identities = 46/226 (20%), Positives = 89/226 (39%), Gaps = 18/226 (7%) Query: 138 GEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 G ++ L EG VV SV +++G D+ LRYAF+ A RK +T K+ I Sbjct: 2 GIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPI 57 Query: 198 SMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 S E + + +Y + + + ++ +R + +P FD + AS + LS + Sbjct: 58 SDGSLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSG 117 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN--PIATIWAGAMMLDFLGNG 314 G + + + ++F+P+ + N AN + + LG+ Sbjct: 118 VCGGANLFSAVEIGDHH---AVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGH- 170 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + + ++ + G +T + G T V I + Sbjct: 171 ----DKCADALWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLR 212 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 132 bits (333), Expect = 2e-29, Method: Composition-based stats. Identities = 65/442 (14%), Positives = 116/442 (26%), Gaps = 122/442 (27%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I + GD E+ R+++ L + + + E Sbjct: 67 IVEMDGD----EMARIMWRMIKDKLIFPYLDLDIRYFDLGILNR-DATDDKVTVESAEAT 121 Query: 67 SRFDAIYFGAVGWPDTV-----PDHISLWGSLLKFRREFDQYVNLRPV------RLFPGV 115 +++ A PD R + V P+ R+ PG Sbjct: 122 LKYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPILCXNVPRIVPGW 181 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV------------------- 156 P+ + R +Y + V + ++V Sbjct: 182 KKPIC----------IGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKG 231 Query: 157 --IQESVFTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY 213 I +++ R + LA + + L +TK+ L Sbjct: 232 PGIALAMYNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG------------- 277 Query: 214 PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA----------------- 256 R++ + ID + A + + V N GD+ SDL Sbjct: 278 ---RYEHRLIDDMVAYALKSDGGY-VWACKNYDGDVQSDLLAQGFLLHMRNERSDYPVXL 333 Query: 257 ----------------CTGTIGI---APSANLNPERTFPSLFEPVHGSAPDI---YGKNI 294 G+ L+ + E HG+ Y K + Sbjct: 334 HLVKSYPILFVLSRIRFFGSYDFSIAISGKQLSSDGKTL-EAEAAHGTVTRHFRQYQKGL 392 Query: 295 ---ANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMK----GN 345 N IA+I+A L+ D ER + + AA E + G T D+ G Sbjct: 393 ETSTNSIASIFAWTRGLEHRAKLDKNERLLDFVHKLEAACIETVESGNMTKDLAILIHGP 452 Query: 346 -------ATTPQVADAICKIIL 360 T + D + + Sbjct: 453 KASXEFYLNTEEFIDTVAHNLE 474 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 103/263 (39%), Gaps = 10/263 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++A + GD V+ + +++++ A ++ + + +P+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDS-TAFEVTELPF-GVNGVLSFNEPLPNQTLR 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLAGK 122 +L +D I GA+ +S+ SL+ R+ + + + V++ PL + Sbjct: 60 ELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLKNQ 119 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 D DF +V+ + + + + +R V++++ FE A +R Sbjct: 120 IVRDTDFIIVQSAK----RANDHVDGNISVDDFAQDTITYEQREVEQVITAGFERAMNRK 175 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T T + + W E +A+ YP++ + + + + + QP DVVVA Sbjct: 176 RA-VTVVTPFDSF-YTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDVVVA 233 Query: 243 SNLFGDILSDLGPACTGTIGIAP 265 +L++ TG P Sbjct: 234 PKWVDQVLNEESQKITGLPETVP 256 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 126 bits (316), Expect = 2e-27, Method: Composition-based stats. Identities = 74/374 (19%), Positives = 127/374 (33%), Gaps = 46/374 (12%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY-------YSHHGKMM 58 + G G G+EV RVL A R ++ + Y G + Sbjct: 32 TVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAGV 91 Query: 59 PD---DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 P+ E + ++ V ++ L R+ LR V+ Sbjct: 92 PEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQ-----RLRAVK----- 141 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +VR+ +G Y+ V + + F+R +++L YA Sbjct: 142 ---VDTLDADGARLLLVRDEAQGFYTG-----GNTHTPGHVSRTTEFSREITEQLLAYAL 193 Query: 176 ELAQSR---PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 A+ + A K + L D V A I D + V Sbjct: 194 RRAREEWPEGPARIVMAYKFHLL---DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLVA 249 Query: 233 QP-ERFDVVVASNLFGDILSDLGPACTGTI----GIAPSANLNPERTFPSLFEPVHGSAP 287 P E V++A N + DI+ + G+ + +L+P ++ VHGSA Sbjct: 250 HPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAVAELVEYQTVHGSAD 309 Query: 288 DIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 D+ G+++ NP+AT+ A A + ++G A V +TPD G Sbjct: 310 DLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGV-----RTPDQGGKH 364 Query: 347 TTPQVADAICKIIL 360 +T V DA + + Sbjct: 365 STTGVVDAFIEELG 378 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 121 bits (304), Expect = 4e-26, Method: Composition-based stats. Identities = 66/125 (52%), Positives = 80/125 (64%), Gaps = 12/125 (9%) Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT- 300 N+FGDILSDLGPACTGTI +APS ++NPE FPSLFEPVHGS PDI+GK IANPI Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 301 --IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG----PKTPDMKGNATTPQVADA 354 GAM+LD LG + I + IE+V++ G P TPD+ G+A T + A Sbjct: 61 ARFGVGAMILDHLGY-----PETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKA 115 Query: 355 ICKII 359 I I Sbjct: 116 IAAAI 120 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 33/114 (28%), Positives = 48/114 (42%), Gaps = 3/114 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 98 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + DA+ GA+G H+ LL+ R + NLRP + P Sbjct: 99 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 105 bits (261), Expect = 4e-21, Method: Composition-based stats. Identities = 31/111 (27%), Positives = 46/111 (41%), Gaps = 9/111 (8%) Query: 96 FRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV 155 D Y ++ ++ P V D+D VV ENTEGEYS+L +G V Sbjct: 2 LHTTLDLYASVIHLKNLPNVET-----WHKDVDILVVWENTEGEYSNLEHESVKG----V 52 Query: 156 VIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 + T+ RI YAF+LAQ K + + K N + + + Sbjct: 53 TESLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 99.6 bits (247), Expect = 1e-19, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 62/164 (37%), Gaps = 14/164 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQ-AAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + ++ + GD IG E++ E ++ L ER F + A + + Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAG-ASLDKTNEPIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-- 115 D + DA+ G+VG P+ +P ++ +L+ R+ D + N+RP R Sbjct: 60 DKVLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRFCASSLV 119 Query: 116 -PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 PL ++F +Y++ ++ + Sbjct: 120 EQSPLKSDMVNGVNF-------GEQYAARSRSTGGCCTKDIGLA 156 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 97.7 bits (242), Expect = 6e-19, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 46/134 (34%), Gaps = 15/134 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+L + + + + FE + S + Sbjct: 50 RHTVTLIPGDGIGPELLNHVRELFRFSC----VPVDFEVVHVNSSSTSEDDIS----NAI 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + T+P + R D Y N+ + PGV + Sbjct: 102 MAIRRNGVALKGNIETNHTMPPN--HKSRNNLLRTSLDLYANVMHCQSLPGVQT-----R 154 Query: 124 PGDIDFYVVRENTE 137 +ID ++ E +E Sbjct: 155 HKNIDIIIILEKSE 168 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 97.3 bits (241), Expect = 7e-19, Method: Composition-based stats. Identities = 52/227 (22%), Positives = 86/227 (37%), Gaps = 30/227 (13%) Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPY---WDERVEAMAENY-- 213 + + F A S K + K + + ++ +A ++ Sbjct: 357 LMSNDHEAIKDWVSQVFRDASS-KHKEVYFGLKREYMEYDEVFSTVINDVRRELAADHTS 415 Query: 214 -PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 P + + P R + A NL GDI SD+ A G++ A S + Sbjct: 416 PPAFMI--MRPSSQLIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASS--IIES 471 Query: 273 RTFPSLFEPVHGSAPDIYGKNIA--------NPIATIWAGAMMLDFLG--NGDERFQQAH 322 ++ LFE HG+A D+Y K + NP A I+A A L+ LG +E Sbjct: 472 KSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYS 531 Query: 323 NGILAAIEEVIAHGPKTPDMKGNATTPQ---------VADAICKIIL 360 + AA+++ + G T D+K TTP+ D+I K + Sbjct: 532 ARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRLG 578 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 94.2 bits (233), Expect = 6e-18, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 110/356 (30%), Gaps = 80/356 (22%) Query: 2 MKTMRIAAIPGD--GIGKEVLPEGI---RVLQAA--------------AERWGFALSFEQ 42 M +IA IPGD GIG E++ + + V +AA A + G L + Sbjct: 6 MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65 Query: 43 MEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQ 102 + WA+ + + E + D S +L + D Sbjct: 66 IAWANLAEF----SGLRQLEMETIDVADV--------KVAEVTIQSGKSALRTLDQALDL 113 Query: 103 YV--NLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE------YSSLGGRVNEGTEHE 154 V + V P L N E E Y G +E + Sbjct: 114 AVAGIVDGVLFGPFNKAALTAAGL----------NAEDEHRYMARYLGFKGYHSEVNVLD 163 Query: 155 VVIQESV------------FTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPY 201 ++ V T GV + + A + + A + N A Sbjct: 164 DLMTTRVTSHIGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGK 223 Query: 202 W-DERVEAMAENYPEIRWDKQHID----ILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + E ++ +A E + H+ + D VV ++ D + Sbjct: 224 FGREEIDILAPVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIK 280 Query: 257 CTG---TIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLD 309 G + +A + + P HG+A DI G+++AN AT A ++L Sbjct: 281 LMGFDRGVTVAGGLPI-------PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLR 329 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 93.1 bits (230), Expect = 1e-17, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 7/113 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I I GDGIG E++ E +VL ++G + +E + C G + D+ Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCS-IDATGVPLTDEAIAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDH------ISLWGSLLKFRREFDQYVNLRPVRLF 112 DA+ G++G + LLK R+ + + NLRP L+ Sbjct: 63 AKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 92.7 bits (229), Expect = 2e-17, Method: Composition-based stats. Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 21/153 (13%) Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 ++ + P R+ + A NL GDI SD+ A G++ A S + + T LFE HG+A Sbjct: 429 SKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTL--LFEAPHGTAH 486 Query: 288 DIYGKNIA--------NPIATIWAGAMMLDFLGNGDERFQ--QAHNGILAAIEEVIAHGP 337 D+Y + + N A I+A A L+ L ++ + + AA+ E +A G Sbjct: 487 DLYLRYLETDGKEANFNSSALIFAVANALEELARREDNAPLAEYAEALKAALIETVAQGT 546 Query: 338 KTPDMKGNATTPQ---------VADAICKIILR 361 T D+KG P+ DAI + + Sbjct: 547 ITGDLKGKTLAPESETVVDMYGFLDAIESNLNK 579 Score = 45.3 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 36/297 (12%), Positives = 83/297 (27%), Gaps = 60/297 (20%) Query: 1 MMKTMRI----AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK 56 M + +++ + GD E+ + + +++ ++ + + +G+ Sbjct: 1 MGERIKVEKPLVILHGD----EMAQIAFERILEQFVTSRLDIQLVEVDLSAEQRLTSNGQ 56 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVP----------------DHISLWGSLLKFRREF 100 ++ + E L A + D ++ R+ Sbjct: 57 VVL-EAIEALKDHGIGVKNAGMTVNRSQLDEMLAKYPQINEAQLDKLATKSPNGAIRKGI 115 Query: 101 DQYVNL-RPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE---YS------SLGGRVNEG 150 N+ R F + DI+ + + G YS + + G Sbjct: 116 GG--NITREDIEFRNLTSVRPDWVNRDIEVDTM--ESGGLDFSYSELSDATGVAKVMFVG 171 Query: 151 TEHEVVIQESVFTRRG------------VDRILRYAFELAQSRPRKTLTSATKSNGLAIS 198 + + V ++G V F+ A R + K + Sbjct: 172 SSGDPVELHRRTLKKGDPWMLATNDLDDVKAWAHRFFQRALDEKRD-IYLGLKDTVVPGY 230 Query: 199 MPYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERFDVV-VASNLFG 247 +E + +++ + ID AR V P + + V N+ G Sbjct: 231 DGVMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNPPQRALWGVPDNVSG 287 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 85.0 bits (209), Expect = 4e-15, Method: Composition-based stats. Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TP 340 VHGSAP G NP A + +G MML +L +A I +++V+A T Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNE-----HEAATRIEKGVDKVLAEAKHLTY 58 Query: 341 DMKGNATTPQVADAICKIIL 360 D G A+T + ADAI K + Sbjct: 59 DAGGTASTDEYADAIIKAMG 78 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 84.2 bits (207), Expect = 6e-15, Method: Composition-based stats. Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%) Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK 338 +EP GSAPDI GKNIANPIA I + AM++ + + + I +A+ + + G + Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRY----TMKLPIISDQIESAVIDTLKKGYR 66 Query: 339 TPDMKGNA----TTPQVADAICKIILR 361 T D+ + +T + D I I+ + Sbjct: 67 TLDIANDKEKCESTNDIGDIISYILKK 93 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 83.5 bits (205), Expect = 1e-14, Method: Composition-based stats. Identities = 44/81 (54%), Positives = 57/81 (70%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + RIA IPGDGIGKE +PE +RV AAA R+GFAL ++AS + + HGK+ PDD Sbjct: 1 MSSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDD 60 Query: 62 WHEQLSRFDAIYFGAVGWPDT 82 + L +DA++FGAVG PDT Sbjct: 61 RFDTLRGYDALFFGAVGRPDT 81 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 81.9 bits (201), Expect = 3e-14, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 60/198 (30%), Gaps = 34/198 (17%) Query: 89 LWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVN 148 R + V P+ L VP L+G + + R +Y + +N Sbjct: 31 WRSPNGTIRNILNGTVFREPI-LCKNVPRILSGWKKP---ICIGRHAFGDQYRATDTIIN 86 Query: 149 EGTEHEVV--------------------IQESVFTRRGVDR-ILRYAFELAQSRPRKTLT 187 + ++V + S++ R + +A S + L Sbjct: 87 GPGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKWPLY 145 Query: 188 SATKSNGLAISMPYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERFDVV 240 +TK+ L + + + + I ++ + ID + A V + V Sbjct: 146 LSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGY-VW 204 Query: 241 VASNLFGDILSDLGPACT 258 N GD+ SD Sbjct: 205 ACKNYDGDVQSDFLAQIF 222 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 81.1 bits (199), Expect = 6e-14, Method: Composition-based stats. Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 5/105 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T I + GDGIG E+ E ++VL +A C G + Sbjct: 360 MTTHTILVLRGDGIGLEITAEAVKVL-SAFSLKKRTFDLRSELIDGCS-IDTDGTPITKT 417 Query: 62 WHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQY 103 + DA+ F +VG P D G LL+ R+ +Q+ Sbjct: 418 VIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 80.0 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDG+G EV+P + VL A G SFE++ G +P + Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGV-ALDLVGVPLPKET 97 Query: 63 HEQLSRFDAIYFGAVGWP 80 + + DA+ GAVGW Sbjct: 98 LIRAKQSDALLLGAVGWY 115 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 75.4 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 8/82 (9%) Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 GSAPDI GKNIANPIA I + AM++ + + + + I +++ + + G KT D+ Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRY----TMKLHKIADDIESSVIDALKKGYKTLDIA 57 Query: 344 G----NATTPQVADAICKIILR 361 + +T + D I I+ + Sbjct: 58 NVNETHISTSDMGDVISNILNK 79 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 75.4 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 6/67 (8%) Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 IANP A + + ML + Q I AI EV+A G +T D+ G+++T + Sbjct: 155 IANPTAMLMCASKMLRHV-----NLQHYSESIRNAIREVLAAGKVRTRDLGGSSSTHEFT 209 Query: 353 DAICKII 359 DA+ K I Sbjct: 210 DAVIKAI 216 Score = 71.1 bits (173), Expect = 6e-11, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 42/103 (40%), Gaps = 8/103 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + IPGDG+ E++ VL+A G + FE + ++ ++ +D Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAI----GAPIDFETILFSEVQH---SSSAKVEDV 115 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVN 105 + ++R GA+ PD L +K R+ D N Sbjct: 116 IKSINRNRICLMGALMSPDVSYSGE-LQNLHMKLRKGLDLIAN 157 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 73.4 bits (179), Expect = 1e-11, Method: Composition-based stats. Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 2/79 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDD 61 KT +IA+IPGD IG EV+ I VL++ E + L F +++W Y GK MP D Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDW-GTARYKRTGKYMPAD 65 Query: 62 WHEQLSRFDAIYFGAVGWP 80 L F A FGAVG P Sbjct: 66 GLSTLKTFHAGIFGAVGAP 84 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 71.5 bits (174), Expect = 4e-11, Method: Composition-based stats. Identities = 32/129 (24%), Positives = 50/129 (38%), Gaps = 9/129 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + F ++ LK + D YV R FPG C Sbjct: 99 EAGQDDEYFHSVLRNRTAVHVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKC--- 155 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D ++ +N G ++ L EG VV SV +++G D+ LRYAF+ A Sbjct: 156 --RFPGVDIQLIGQNNMGIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAK 209 Query: 181 RPRKTLTSA 189 RK +T Sbjct: 210 AGRKRVTLI 218 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 68.4 bits (166), Expect = 4e-10, Method: Composition-based stats. Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 3/79 (3%) Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP 340 P+HG APDI G IANP A + A +L G +E QQ N I +A E TP Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGY-EELAQQVENQIESAFYE--NRDQTTP 265 Query: 341 DMKGNATTPQVADAICKII 359 D G T + + + I Sbjct: 266 DQGGVLNTEKYMAMMVECI 284 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 65.3 bits (158), Expect = 3e-09, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 28/75 (37%), Gaps = 11/75 (14%) Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NA 346 NIANP + A ML ++G I A + + G T D+ Sbjct: 6 NIANPSGLLNAAVHMLIYIGQVGT-----AKLIYDAWLKTLEGGIHTADLYKEKRSKQKV 60 Query: 347 TTPQVADAICKIILR 361 T + A+A+ + + Sbjct: 61 GTKEFAEAVIDNLGK 75 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 65.3 bits (158), Expect = 4e-09, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 31/77 (40%), Gaps = 5/77 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ IPGDGIG E+ ++ +AA + ++ ++ + + +P E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA----NAPIEWDPVDVTPVKGDDGIFR-IPSKCIEL 81 Query: 66 LSRFDAIYFGAVGWPDT 82 + G + P+ Sbjct: 82 MRINKIGLKGPLATPNW 98 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 65.0 bits (157), Expect = 4e-09, Method: Composition-based stats. Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 1/61 (1%) Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHG 336 +FEP HGSAPDI G+NIANPIA IW+GA ML G + A + V+ Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHRHPSAAGHGANKAVMIDA 60 Query: 337 P 337 Sbjct: 61 T 61 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 63.8 bits (154), Expect = 1e-08, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 28/82 (34%), Gaps = 7/82 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + IPGDGIG E+ + + + +EQ + G+ + E Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYV----NAPIEWEQYNVSGMSSA---GEDLFKQAVE 61 Query: 65 QLSRFDAIYFGAVGWPDTVPDH 86 L R G + P + H Sbjct: 62 SLRRNRVGLKGILFTPISQSGH 83 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.9 bits (149), Expect = 4e-08, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 37/107 (34%), Gaps = 31/107 (28%) Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 +GP +G+ L E ++Y KNIANP AT+ A MMLD L Sbjct: 25 VGPELMAAVGVIECLKLGDGLFLQCCEE-----VAELYPKNIANPTATLLASCMMLDHL- 78 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 KT DM G AT +A+ + Sbjct: 79 -------------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 60.0 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 10/93 (10%) Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 L G QP ++ +V EN EGEYS GR + E++I + + A+ Sbjct: 80 RSSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG---------LSKIAY 130 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 +L + P K + ATKSN + W+E Sbjct: 131 QLLRG-PEKHIAIATKSNAQRNGLVIWNEVAAE 162 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 56.9 bits (136), Expect = 1e-06, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 30/102 (29%), Gaps = 3/102 (2%) Query: 148 NEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVE 207 + + V +R A + + L A K N + + + Sbjct: 138 PREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAA 197 Query: 208 AMAEN---YPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 E+ I W ID + A V P + ++ + F Sbjct: 198 ETLESLAGAAGIAWRSLIIDHMAAELVRNPLDYRAILTHSSF 239 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 55.3 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 3/55 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG 55 M K +I +PGDGIG E++ E ++VL+ A E++ + HG Sbjct: 8 MSK--QILILPGDGIGPEIMTEAVKVLELANEKYQLGFELT-HDVIGGAAIDKHG 59 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 55.3 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 6/62 (9%) Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + A +MLD L + N I +AI + T D+ G TT +V +I +I Sbjct: 1 MLLASCLMLDHL-----KLHDYANMIRSAILTTMNETRLHTVDIGGQGTTSEVVQSIMRI 55 Query: 359 IL 360 I Sbjct: 56 IQ 57 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 49.6 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 19/37 (51%) Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 R + +T K+N + ++ + +A+++P++ Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 49.6 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 16/47 (34%), Positives = 28/47 (59%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS 52 +I A+ GDGIG E++ G+ VL+A AE+ GF ++ + + + Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGADIDA 50 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 48.8 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 12/113 (10%), Positives = 25/113 (22%), Gaps = 10/113 (8%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++ + D G E+ ++ + + + Y + Sbjct: 42 KRIKVSQPVVEMD--GDEMTRIIWEFIKEKLILSNVDVELKYYDL-GLPYRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRP 108 D ++ A PD R V P Sbjct: 99 DSAIATQKYHVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTVFREP 151 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 47.2 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 15/27 (55%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAE 32 + IPGDGIG E+ +++ AA Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKA 32 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 46.1 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 25/79 (31%), Gaps = 14/79 (17%) Query: 296 NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKG--------- 344 NPIA+I+A L D + N + E I G T D+ Sbjct: 6 NPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSAQ 65 Query: 345 ---NATTPQVADAICKIIL 360 T + + + + + Sbjct: 66 CSDYLNTFEFMEKLGENLK 84 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 45.3 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 22/37 (59%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQ 42 +I A+ GDGIG E++ G+ VL+A AE+ + Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEKQVLTMRLTD 40 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 44.5 bits (104), Expect = 0.007, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 46/174 (26%), Gaps = 18/174 (10%) Query: 188 SATKSNGLAISMPYWDERVEAMAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASN 244 K N + + + + E I + ID + A P+ + ++ Sbjct: 1 MTHKGNSIKYTDGLFAVVAKQELEKLIGDSGIIQESLIIDHMAAELTRNPQDYRAILTHG 60 Query: 245 ---------LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 L G + +D TIG A + H AP+ Sbjct: 61 AFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDP---ARHTRAPEAEAAGRL 116 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 + + AG+++ D L G T + A T Sbjct: 117 RSV--LLAGSLLADHLDQGVAAAGIRAAADALDAPATADGHAGTAGLAACARTA 168 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 44.2 bits (103), Expect = 0.008, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 25/52 (48%), Gaps = 6/52 (11%) Query: 310 FLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G G++ N I A+E+V+ +T + G+ATT + A + + Sbjct: 39 HVGEGEK-----ANAIRNAVEKVLNIDNVRTGGLGGSATTKEFTAATERRLA 85 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 43.8 bits (102), Expect = 0.009, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 31/83 (37%), Gaps = 14/83 (16%) Query: 292 KNIANPIATIWAGAMMLDFLGNGDE--RFQQAHNGILAAIEEVIAHGPKTPDM----KGN 345 K NPIA+I+A + L+ D+ R + + A E + G + D+ G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 346 --------ATTPQVADAICKIIL 360 T+ + D + + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERLK 85 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 43.8 bits (102), Expect = 0.009, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 23/71 (32%), Gaps = 8/71 (11%) Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-------NYPE 215 T + + A + L +TK+ L + + + + E Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 216 IRWDKQHIDIL 226 I ++ + ID + Sbjct: 60 IWYEHRLIDDM 70 >UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Lactobacillus paracasei subsp. paracasei 8700:2 RepID=C5F751_LACPA Length = 326 Score = 42.2 bits (98), Expect = 0.027, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 54/158 (34%), Gaps = 17/158 (10%) Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPYW-DERVEAMAENYPEIRW 218 + T+ V+ + A + A N A + DE ++ + E + Sbjct: 174 LVTKARVEECIDLANSAIKRLGISKPRIAVAGLNPHAGEDGLFGDEEIKEINPAVKEKQS 233 Query: 219 DKQHIDIL----CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN--LNPE 272 + +FD+VVA ++ D G + N L Sbjct: 234 QGIDVQGALPPDTVFLKASQGKFDIVVA--MYHD----QGHIPMKLLAFDEGVNVTLGLP 287 Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDF 310 S+ HG+A DI GK IAN + + + A+ + F Sbjct: 288 IIRTSV---DHGTAFDIAGKGIANESSMLASIALAIKF 322 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 42.2 bits (98), Expect = 0.031, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 18/45 (40%), Gaps = 4/45 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA 46 ++ PGDGIG E+ +V AA + +++ Sbjct: 41 STPIKATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVG 81 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 41.8 bits (97), Expect = 0.033, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 13/26 (50%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQA 29 + IPGDGIG E++ V + Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10 Tax=Proteobacteria RepID=PDXA2_PSEAE Length = 337 Score = 41.8 bits (97), Expect = 0.034, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 31/94 (32%), Gaps = 16/94 (17%) Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTG---TIGIAPSANLNPERTFPSLF 279 D + + FD VV ++ D + G + + + + Sbjct: 252 ADTIFLKVQGDARAFDAVVT--MYHD-QGQIAIKLMGFSRGVTVQGGLPI-------PIA 301 Query: 280 EPVHGSAPDIYGKNIANPIATIWA---GAMMLDF 310 P HG+A DI G+ A+ AT A M Sbjct: 302 TPAHGTAFDIAGQGRADVGATRQAFEIACRMGRH 335 >UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q0V0_9BACT Length = 346 Score = 41.5 bits (96), Expect = 0.053, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 12/88 (13%) Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV 282 D + + + ++D+VV+ ++ D + N+ F P Sbjct: 261 ADTVFYKALK--GQYDLVVS--MYHD-QGAIPLKLH---AFETGVNITLGIPFIRT-SPD 311 Query: 283 HGSAPDIYGKNIANPIAT---IWAGAMM 307 HG+A DI GK IANP + I MM Sbjct: 312 HGTAYDIAGKGIANPDSMKEAIMTAIMM 339 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 430 e-119 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 424 e-117 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 408 e-112 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 405 e-111 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 402 e-111 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 396 e-109 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 395 e-108 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 394 e-108 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 394 e-108 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 393 e-108 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 392 e-108 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 391 e-107 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 387 e-106 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 385 e-105 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 385 e-105 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 383 e-105 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 383 e-105 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 383 e-105 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 383 e-105 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 382 e-104 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 381 e-104 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 381 e-104 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 380 e-104 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 380 e-104 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 379 e-104 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 379 e-103 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 377 e-103 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 376 e-103 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 376 e-103 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 375 e-102 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 371 e-101 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 370 e-101 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 370 e-101 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 369 e-101 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 369 e-101 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 369 e-101 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 369 e-101 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 368 e-100 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 368 e-100 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 368 e-100 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 367 e-100 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 367 e-100 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 366 e-100 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 366 e-100 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 366 e-100 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 365 1e-99 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 365 1e-99 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 365 2e-99 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 365 2e-99 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 364 3e-99 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 360 6e-98 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 358 1e-97 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 356 6e-97 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 356 9e-97 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 355 1e-96 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 355 1e-96 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 355 1e-96 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 355 1e-96 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 355 2e-96 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 355 2e-96 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 354 2e-96 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 354 4e-96 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 353 8e-96 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 352 9e-96 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 352 1e-95 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 351 3e-95 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 350 4e-95 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 350 7e-95 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 349 1e-94 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 348 2e-94 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 348 2e-94 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 348 2e-94 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 345 1e-93 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 344 2e-93 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 344 4e-93 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 343 4e-93 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 343 6e-93 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 343 7e-93 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 342 1e-92 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 342 1e-92 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 341 2e-92 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 341 2e-92 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 340 6e-92 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 338 2e-91 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 338 3e-91 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 337 3e-91 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 337 4e-91 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 336 7e-91 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 336 7e-91 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 336 8e-91 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 335 1e-90 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 334 3e-90 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 334 3e-90 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 332 1e-89 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 331 2e-89 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 331 3e-89 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 329 6e-89 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 329 8e-89 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 329 9e-89 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 329 1e-88 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 328 1e-88 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 328 2e-88 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 328 2e-88 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 327 3e-88 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 326 5e-88 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 325 1e-87 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 322 1e-86 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 322 1e-86 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 320 4e-86 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 320 5e-86 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 319 9e-86 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 319 1e-85 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 318 2e-85 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 316 7e-85 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 316 8e-85 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 316 9e-85 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 316 9e-85 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 314 2e-84 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 314 2e-84 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 314 3e-84 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 314 4e-84 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 312 1e-83 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 308 2e-82 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 307 3e-82 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 307 3e-82 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 306 8e-82 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 306 9e-82 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 304 2e-81 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 303 7e-81 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 300 4e-80 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 300 5e-80 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 296 6e-79 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 296 7e-79 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 296 9e-79 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 294 5e-78 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 293 6e-78 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 291 3e-77 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 289 9e-77 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 287 5e-76 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 286 1e-75 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 281 3e-74 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 277 4e-73 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 277 5e-73 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 274 2e-72 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 274 3e-72 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 272 1e-71 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 271 3e-71 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 269 8e-71 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 267 3e-70 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 261 3e-68 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 260 5e-68 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 259 2e-67 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 258 3e-67 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 257 4e-67 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 257 6e-67 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 253 7e-66 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 249 9e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 249 1e-64 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 249 1e-64 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 237 4e-61 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 232 1e-59 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 230 8e-59 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 229 9e-59 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 226 8e-58 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 222 1e-56 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 216 8e-55 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 215 2e-54 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 214 4e-54 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 211 3e-53 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 207 5e-52 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 205 2e-51 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 202 1e-50 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 198 3e-49 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 196 8e-49 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 195 2e-48 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 188 3e-46 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 187 5e-46 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 187 7e-46 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 185 3e-45 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 184 5e-45 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 178 3e-43 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 175 2e-42 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 175 2e-42 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 165 3e-39 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 164 4e-39 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 150 9e-35 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 147 5e-34 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 147 5e-34 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 144 4e-33 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 135 2e-30 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 131 5e-29 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 130 7e-29 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 121 5e-26 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 111 4e-23 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 111 4e-23 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 107 8e-22 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 103 1e-20 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 103 1e-20 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 100 7e-20 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 100 2e-19 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 90 9e-17 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 90 2e-16 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 85 3e-15 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 85 4e-15 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 82 3e-14 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 81 5e-14 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 79 2e-13 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 78 4e-13 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 77 1e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 76 2e-12 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 73 2e-11 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 70 2e-10 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 68 6e-10 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 67 1e-09 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 66 1e-09 UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 66 1e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 65 3e-09 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 63 2e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 61 5e-08 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 61 6e-08 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 56 2e-06 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 56 3e-06 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 51 5e-05 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 51 7e-05 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 50 1e-04 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 46 0.002 Sequences not found previously or not previously below threshold: UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 51 9e-05 UniRef50_D2H627 Putative uncharacterized protein n=1 Tax=Ailurop... 46 0.003 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 46 0.003 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 46 0.003 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 45 0.006 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 44 0.010 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 43 0.012 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 43 0.014 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 42 0.031 UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n... 41 0.045 UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 41 0.066 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 430 bits (1106), Expect = e-119, Method: Composition-based stats. Identities = 278/363 (76%), Positives = 311/363 (85%), Gaps = 2/363 (0%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIAAIPGDGIG EVLPEGIRVL+AAA + G AL F+ EWASC+YY HGKMMP Sbjct: 1 MPAHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMP 60 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW EQL ++DAIYFGAV WPD VPDHISLWGSLLKFRREFDQYVN+RPVRLFPGVPC L Sbjct: 61 DDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCAL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 A ++ GDIDF VVRENTEGEYSSLGG + E TE+E+VIQES+FTRRGVDRIL+YAF+LA+ Sbjct: 121 ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAE 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD- 238 R RK +TSATKSNG+AISMPYWD+R EAMA +YP + WDKQHIDILCARFV+QPERFD Sbjct: 181 KRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDV 240 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVVASNLFGDILSDLGPAC GTIGIAPSANLNPER FPSLFEPVHGSAPDI+GKNIANPI Sbjct: 241 VVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPI 300 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A IW+GA+ML+FLG GDER+Q+AH+ +L AIE VIA G TPDM G +T QV AI Sbjct: 301 AMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDMGGTLSTQQVGAAISDT 360 Query: 359 ILR 361 + R Sbjct: 361 LAR 363 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 424 bits (1090), Expect = e-117, Method: Composition-based stats. Identities = 254/360 (70%), Positives = 298/360 (82%), Gaps = 2/360 (0%) Query: 1 MMKT-MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIA IPGDGIG EV+PEG+R L A + R+G ++E +EWASC+YY+ HG+MMP Sbjct: 36 MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP 95 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW QLS DA+ FGAVGWP+TVPDHISLWGSL+KFRREFDQYVNLRP RLF GVPCPL Sbjct: 96 DDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPL 155 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 AG++ GDIDF +VRENTEGEYS++GG + EGTE E V+Q++VFTR G +R+L++AFELAQ Sbjct: 156 AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQ 215 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R K LT ATKSNG+AISMP+WD R MA YP++ WDKQHIDILCARFVMQP+RFDV Sbjct: 216 RRA-KRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDV 274 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 VVASNLFGDILSDLGPACTGTIGIAPSANLNPER FPSLFEPVHGSAPDI GK+IANPIA Sbjct: 275 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIA 334 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 IW+ AMM+DFLG G ++AH+ I+AAIE V+ HGP+T DM G A+T +V DAI + Sbjct: 335 MIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHL 394 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 408 bits (1050), Expect = e-112, Method: Composition-based stats. Identities = 223/359 (62%), Positives = 268/359 (74%), Gaps = 9/359 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +IA IPGDGIG EV+PEGIRVL+AA+ ++GF L+F +W SC Y G MMP D Sbjct: 5 QQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDW-SCARYHSQGSMMPSDG 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L DAI+ GAVG+P VPDH+SLW L+ RREFDQYVNLRPVRL PGVPCPLA K Sbjct: 64 IERLRDSDAIFLGAVGFP-GVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANK 122 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +PGDIDF++VRENTEGEYS +GGR+ GTEHE V QE++FTRRG DRI+RYAF+LA+ Sbjct: 123 KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFDLAKKLG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +TSATKSNG+ SMP+WDER A+ YP+IR D+ HIDIL ARF M PERFDVVV Sbjct: 183 RNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPERFDVVVG 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGP TGTI +APSAN+NPER +PS+FEPVHGSAPDI G+ IANPI IW Sbjct: 243 SNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIW 302 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA--HGPKTPDMKGNATTPQVADAICKII 359 +GAMML+ LG +A I+ AIE V+ TPD+ G A+T Q+ I + + Sbjct: 303 SGAMMLEHLGQ-----PEAAAAIMQAIETVLTHPDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 405 bits (1042), Expect = e-111, Method: Composition-based stats. Identities = 181/360 (50%), Positives = 243/360 (67%), Gaps = 8/360 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ +IAAIP DGIG EV+ G++VL+A +R G F++ E +W +YY +G MMP Sbjct: 1 MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDW-GSDYYKKNGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL +FDAI+FGAVG PD VPDHI+LWG L + FDQY N+RP ++ PG+ PL Sbjct: 60 DGLEQLKKFDAIFFGAVGAPD-VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLR 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 PGD+D+ +VREN+EGEYS GGR ++G EV + ++FTR GV RI+RYAF+LAQ+ Sbjct: 119 NCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQA 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN M WDE +++ +P++ WDK +D + R ++P+ D + Sbjct: 179 RPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++G+AP+AN++PER FPS+FEP+HGSA DI GK IANP+AT Sbjct: 239 VATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVAT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W A ML+ LG D A +++A+E V G TPD+ G A T QV DA+C+ I Sbjct: 299 FWTAAQMLEHLGEKD-----AATRLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAIA 353 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 402 bits (1034), Expect = e-111, Method: Composition-based stats. Identities = 173/359 (48%), Positives = 231/359 (64%), Gaps = 9/359 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 T RIA+IPGDGIG EV+ I+V++ A+ G F + F + W YY HG+ + +D Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPW-GTAYYKEHGRYVSEDC 104 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L +FDA FGAVG PD VPDHISLWG LL R Y N+RPVR FPG CPL Sbjct: 105 LDTLRKFDAGLFGAVGAPD-VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPL-NT 162 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ +VREN+EGEYS GGR + G E + ++FTR G++RI+R+AFE+AQSRP Sbjct: 163 ATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEVAQSRP 222 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK LT TKSN + M WD+ +A+++P++ WDK +D + R V +P+ D +V Sbjct: 223 RKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSIDTIVG 282 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NL DILSDL A G+IG+APS+NL+P R PS+FEPVHGSA DI GK +ANP+AT W Sbjct: 283 TNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFW 342 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + A ML +LG ++A ++ +E+V A G TPD+ G + T V DA+ K I R Sbjct: 343 SAAEMLSWLGE-----KEAAKQLMDCVEKVCAAGILTPDLGGTSNTQGVVDAVKKEIER 396 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 179/362 (49%), Positives = 229/362 (63%), Gaps = 9/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MKT RIA IPGDGIGKEV+P G + +Q AE G F F+ +W +YY HG MMP Sbjct: 1 MKTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGG-DYYRRHGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E L DAI FG+ G PD DHI+LWG LK + DQY N+RP RL PG+ PL Sbjct: 60 DGLEPLRDKDAILFGSAGDPDIA-DHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLK 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D+ +VREN+EGEYS +GGRV++G E S+ TR GV+RILRYAF LAQS Sbjct: 119 RCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFRLAQS 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN +M WDE ++ +P++RWDK+ +D AR V +P D + Sbjct: 179 RPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPASLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++GIAP+ N++PER PS+FEP+HGSA DI GK +ANPI T Sbjct: 239 VATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 W+ M+L+ LG QA ++ A+E V A T D+ G ATT QV A+C+ + Sbjct: 299 FWSVVMLLEHLGE-----HQAAARMMRAVESVTADQALHTRDLGGTATTEQVTQAVCQHL 353 Query: 360 LR 361 + Sbjct: 354 RQ 355 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 395 bits (1014), Expect = e-108, Method: Composition-based stats. Identities = 126/357 (35%), Positives = 181/357 (50%), Gaps = 27/357 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T +I IPGDGIG EV +RVL+A G +E A E Y + + +P + + Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA----TGLKFEWESF-AAGAEAYEKYKEYIPKELN 56 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G V P ++ R+ F+ Y N+RP+R PGV + Sbjct: 57 ESIERTRIGLKGPVTTPI----GGGFSSINVELRKRFELYANVRPIRNLPGVHT-----R 107 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D VVRENTEG YS + V G VV + T + RI ++AF A+ R Sbjct: 108 YPGVDLVVVRENTEGLYSGIEHEVVPG----VVESLKIITEKASTRISKFAFNYARKMGR 163 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K + S K+N + +S + +++ YPEI + + +D C + VM P ++D+++ Sbjct: 164 KKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLE 223 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SDL G +G+AP AN+ S+FE VHGSAPDI GKNIANP A I + Sbjct: 224 NLYGDIVSDLCAGLVGGLGLAPGANIGER---ASIFEAVHGSAPDIAGKNIANPTAVIRS 280 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 G +ML L D A N + AA+ V G T DM G +T + AD + + I Sbjct: 281 GILMLRHLDEQD-----AANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 104/357 (29%), Positives = 167/357 (46%), Gaps = 27/357 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +A IPGDGIG E+ + + A + +E ++ + MP + Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTPRPTEDGRFR-MPQSSLDI 2032 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+EF+ Y N+RP + G P Sbjct: 2033 IRKHGIGLKGPLATPI----GKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYK----- 2083 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ++D VRENTEGEYS + + +G VV + T R+ R+AF+ A+ R++ Sbjct: 2084 NVDLVTVRENTEGEYSGIEHVIVDG----VVQSIKLITEEASRRVARFAFQYAKDNGRRS 2139 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + A ++ EI + +D +C V P RFDV+V NL Sbjct: 2140 VTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNL 2199 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI G++ ANP A +++ Sbjct: 2200 YGDILSDLAAGLIGGLGVTPSGNIGETG---AIFESVHGTAPDIAGQDRANPTALLFSAI 2256 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 MML ++ + + I +A+ I T D+ G +T Q IC+ I + Sbjct: 2257 MMLRYM-----NLNKHADLIESAVLATIREAKYLTADLGGRSTCSQYTKEICRQIEQ 2308 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 109/359 (30%), Positives = 169/359 (47%), Gaps = 32/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ IPGDGIG E+ RV A + +E + + + + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKA----PIEWETVVVDA-------NTGISKE 69 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E +S+ G + P L R+ F+ Y N+RP PG Sbjct: 70 VIESISKNKIGLKGPISTPI----GTGHQSLNLGLRKTFNLYANIRPCLSIPGHKT---- 121 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + +++ VVRENTEGEYS + + +G V + T+ RI YAF+ A + Sbjct: 122 -RYNNVNTVVVRENTEGEYSGIENQPVKG----VAQSIKIITKEASTRIAHYAFQYALAN 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T K+N + S + + ++ YP I++++ ID C + V+ P + DV+V Sbjct: 177 GRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQMDVMV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDI+SDL G +G+ PS N+ + ++FE VHG+APDI GKN ANP A I Sbjct: 237 LPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGS--AIFEAVHGTAPDIAGKNKANPTALI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + MML LG+ E + I A+ + G T D+ GN++ + D + K I Sbjct: 295 LSSIMMLRHLGHFHE-----ASIIENAVLNTLTEGKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 393 bits (1011), Expect = e-108, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 184/355 (51%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIGKEV+ + +L+ + + + A E +GK +PD+ E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILE----KLDLPFEYSYYD-AGDEALEKYGKALPDETLEA 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA+ FGA G + +++ RRE + N+RP + G+ C Sbjct: 58 CRKSDAVLFGAAG--------ETAADVIVRLRRELGTFANVRPAKAIEGIECLY-----P 104 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D VVRENTE Y +V V TR +RI RYAFELA+ RK Sbjct: 105 GLDIVVVRENTECLYMGFEFGFG-----DVTEAIRVITREASERIARYAFELAKREGRKK 159 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A++YPEI+++ +ID C VM P RFDV+V +N+ Sbjct: 160 VTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDI+SDL G +G+APSAN+ ++FEPVHG+A DI GK IANP A I Sbjct: 220 FGDIVSDLAAGLVGGLGLAPSANVGER---TAIFEPVHGAAFDIAGKGIANPTAMILTAC 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML G +E + A+E+ I G KTPD+ GN T + A+ + ++ Sbjct: 277 MMLRHFGYVEE-----AKKVEEAVEKTIKEGKKTPDLGGNLKTMEFANEVASLLD 326 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 392 bits (1008), Expect = e-108, Method: Composition-based stats. Identities = 175/362 (48%), Positives = 242/362 (66%), Gaps = 10/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M+ RIA +PGDGIG EV+ E ++VL+ ++ + F + W S EYY HG+MMP+ Sbjct: 1 MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNS-EYYLQHGRMMPE 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + L +DAI FGA+G P VPD IS+W ++ R+ F QYVNLRPV+ G+P Sbjct: 60 NGLDILKNYDAILFGAIGDPR-VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFI 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ I+F +VREN EGEYS+ GGR+ +GT+ E+ +Q ++ TR+G +RI RYAF+ A+ Sbjct: 119 HQERP-INFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKK 177 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + +ATKSN + SM WDE +E +A YP+I+ +K +ID L A FV +P+ V+ Sbjct: 178 HGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDLG A G +GI+PSAN+NPE FPS+FEPVHGSAPDI GK ANPIA Sbjct: 238 VASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 IW+ A+ML LG D + IL AIE+V HG T D+ GN+TT ++ + I + I Sbjct: 298 IWSAALMLQSLGRED-----LASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQI 352 Query: 360 LR 361 ++ Sbjct: 353 VK 354 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 108/361 (29%), Positives = 181/361 (50%), Gaps = 24/361 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M I+ + GDGIG E+ + +L+A + + +L +++E A + GK +PD Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLE-AGDAVLKNTGKALPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + DA VG S ++ RR D Y N+RP + +P +P Sbjct: 60 ETFEAIKNSDACLKAPVG--------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D+D +VRENTE Y+ + + + + + + RI YAF +A Sbjct: 110 ---RDDVDLVIVRENTEDLYTGEEFDIG-----DAAVAFRIISEKASKRIANYAFTIASK 161 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R K +T KSN + + + +A ++P++++++ ++D + QP+ FDV+ Sbjct: 162 RKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQLFDVI 221 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDILSD G +G+AP+AN+ LFEPVHG+A DI GK IANP + Sbjct: 222 VTTNLFGDILSDESAQVVGGLGMAPAANIGDN---FGLFEPVHGAAFDIAGKQIANPTSF 278 Query: 301 IWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 I + MMLD+LG + D++ + + + +++ + KT D+ G+ TT + I Sbjct: 279 ILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGDKTTMEFTKEIISR 338 Query: 359 I 359 + Sbjct: 339 L 339 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 180/359 (50%), Positives = 218/359 (60%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ IA IPGDGIG++V +VL A GF L+ W SC +Y G MMP D Sbjct: 1 MKSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPW-SCAFYKETGAMMPPD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L RFDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL GV PL Sbjct: 60 GIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLK- 118 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV++GT EV ++ S+FTR GV+RILR+ F+ A+ R Sbjct: 119 --AEGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQARQR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ L S TKSN SM WDE +A YP++ HID + AR VM PE DVVV Sbjct: 177 -RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLDVVV 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMMLD LG +A ++ A+E A G T G T + A+ + Sbjct: 296 WSGAMMLDHLGQ-----ARAARKVIEALERTTARGIGTVP--GKNRTETITAAVLAALD 347 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 187/361 (51%), Positives = 244/361 (67%), Gaps = 11/361 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IAAIPGDG+GKEV+ +VL AAE G + SF W SC+YY HGKMMP+ Sbjct: 3 MKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPW-SCDYYLEHGKMMPE 61 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L++F+A++ GAVG P VPDHISLWG LLK RRE + +N+RP + G+ PL Sbjct: 62 DGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPL- 120 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 P D DF V+REN+EGEYS +GGR++ G + E+ IQ +VFTR+ +R++R+AFELA+ Sbjct: 121 -LHPNDFDFVVIRENSEGEYSEVGGRIHRG-DDEIAIQNAVFTRKATERVMRFAFELAKK 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R +TSATKSNG+ +MP+WDE + A +Y I QHID L A FV +PE FDV+ Sbjct: 179 R-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDIL+D+ + G+IGIAPSAN+NP +PS+FEPVHGSAPDI G+ +ANPI Sbjct: 238 VASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 IW +MLD G ++ IL +E+V A G KT D+ G +TT +V D IC + Sbjct: 298 IWTAKLMLDHFGE-----EELGAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEICSRLR 352 Query: 361 R 361 + Sbjct: 353 K 353 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 167/361 (46%), Positives = 220/361 (60%), Gaps = 11/361 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +IA IPGDG G E + EG++VL AAA + GFAL ++W EYY G+++P Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGG-EYYLRTGEVLPP 71 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL R+DAIY GA+G P+ P I G LL+ R E DQY+NLRPV+L+PGV P+A Sbjct: 72 DAVEQLKRYDAIYLGAIGHPEVRP-GILEKGILLRLRFELDQYINLRPVKLYPGVETPIA 130 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 GK P DIDF VVRENTEG Y+ GG + GT EV IQ S+ TR+GV+R +R+AFE + Sbjct: 131 GKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAFEYCRK 190 Query: 181 R-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R+ +T K+N L + W+ + E YP+I D H+D +C V PE FDV Sbjct: 191 RGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNPEWFDV 250 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDI++DLG G +GIA NLNPE S+FEP+ GSAP GKN+ NP+A Sbjct: 251 IVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPE--GVSMFEPIGGSAPKYTGKNVINPLA 308 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA-TTPQVADAICKI 358 + AGAMML+ LG A I A+++V A K+ T +V D + Sbjct: 309 AVCAGAMMLEQLGETG-----AAARIEEAVKKVCAGHLKSLAAGRMGYGTDEVGDLVVSH 363 Query: 359 I 359 + Sbjct: 364 L 364 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 126/366 (34%), Positives = 188/366 (51%), Gaps = 29/366 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 MM ++ I GDGIGKEV+PE I++L E A E +G +P+ Sbjct: 1 MM---KVCVIEGDGIGKEVIPEAIKILNELGEFEIIKGE------AGLECLKKYGNALPE 51 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP-----GV 115 D E+ D I FGA+ P + + ++ R+ F Y N+RP+ F G Sbjct: 52 DTIEKAKEADIILFGAITSPK-PGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGK 110 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 +ID ++RENTE Y E++ I E V TR+G +RI+R+AF Sbjct: 111 IADYEFLNAKNIDIVIIRENTEDLYVGRER-----LENDTAIAERVITRKGSERIIRFAF 165 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A RK ++ K+N L I+ + E + ++Y I D +D + PE Sbjct: 166 EYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPE 224 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V +N+FGDILSD A G +G+APSAN+ ++ +LFEPVHGSAPDI GK IA Sbjct: 225 KFDVIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK---ALFEPVHGSAPDIAGKGIA 281 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP+A+I + AM+ D++G ++ + I A++ + + TPD+ G+ T V D I Sbjct: 282 NPMASILSIAMLFDYIGEKEK-----GDLIREAVKYCLINKKVTPDLGGDLKTKDVGDEI 336 Query: 356 CKIILR 361 I + Sbjct: 337 LNYIRK 342 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 107/356 (30%), Positives = 170/356 (47%), Gaps = 26/356 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPGDGIG E+ +++ AA + +E+ + + M+P + E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQWEERNVTAIQGP-GGKWMIPSEAKES 87 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+ FD Y N+RP G P Sbjct: 88 MDKNKMGLKGPLKTPIAA----GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT----- 138 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D++ +RENTEGEYS + + +G VV + T RI +AFE A++ R Sbjct: 139 DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLITEGASKRIAEFAFEYARNNHRSN 194 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + ++ +AE+ +I++++ ++D +C V P +FDV+V NL Sbjct: 195 VTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNL 254 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI GK++ANP A + + Sbjct: 255 YGDILSDLCAGLIGGLGVTPSGNIGA--NGVAIFESVHGTAPDIAGKDMANPTALLLSAV 312 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 MML +G I AA I G T D+ GNA + IC+ + Sbjct: 313 MMLRHMG-----LFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVK 363 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 132/367 (35%), Positives = 190/367 (51%), Gaps = 18/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M++ +A + GDGIG EV+ E ++VL E++GF L+F + H G +P + Sbjct: 1 MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGG-AAIDHCGYPLPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + DAI FG+VG P PD G+LL R+ F + NLRP L+ G+ Sbjct: 60 TLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKF 119 Query: 117 CPLAGKQP-GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 CPL D VVRE T G Y V+ + ++RI R AF Sbjct: 120 CPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAF 179 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A R K +TS K+N L S+ W E V MA++YPE+ + +ID + + PE Sbjct: 180 EAAMKRN-KKVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPE 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDV++ SN+FGDI+SD TG++G+ PSA+LN L+EP GSAPDI GK IA Sbjct: 238 SFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNE--AGFGLYEPAGGSAPDIAGKGIA 295 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG---NATTPQVA 352 NPIA I + AMML + +A + I +A+++V+A G +T D+ +T ++ Sbjct: 296 NPIAQILSAAMMLRY----SFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMG 351 Query: 353 DAICKII 359 I + I Sbjct: 352 TLITQAI 358 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 113/375 (30%), Positives = 173/375 (46%), Gaps = 41/375 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ IPGDGIG EV VL+A G L + ++E A E +G +P E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVE-AGVEVIEKYGTPLPPQVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G +G P + R+E D Y NLRP + PG+ P Sbjct: 58 SIRETRVAIKGPIGTP----VGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSP-----F 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTE----------------HEVVIQESVFTRRGVD 168 DID VVRENTE Y+ + I + G Sbjct: 109 QDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSR 168 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 RI+++AFE A+ RK +T+ K+N + + + + +A+ YP+I ++ +D +C Sbjct: 169 RIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCL 228 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + +P+ +DV+V +NL+GDI+SDL G +G+AP AN+ ++FE +HGSAP Sbjct: 229 QLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD---GIAVFEAIHGSAPK 285 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM--KGN 345 G+N NP A I +GAMML +LG + + + VIA G T D+ Sbjct: 286 YAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAV-----QSVIAEGKYVTYDLAQGEP 340 Query: 346 ATTPQVADAICKIIL 360 T ++A+AI + Sbjct: 341 VGTQEMAEAIAARVQ 355 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 125/359 (34%), Positives = 180/359 (50%), Gaps = 31/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+M+IA IPGDGIG EV+ + +L L F + A G +P++ Sbjct: 1 MKSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHAD-AGDACLKRTGTALPEE 55 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E + A FGA G S +++ RREFD + NLRPV+ PGVPC Sbjct: 56 TLEAVGEARATLFGAAG--------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY-- 105 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D+DF +VRENTE Y EG + + + TR RI ++AF+ AQ Sbjct: 106 ---PDLDFVIVRENTEDLYVGDEEYTPEG-----AVAKRIITRTASRRISQFAFQYAQKE 157 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + +T+ K+N L + + + +A YP++ ++D + QP+ F +V Sbjct: 158 GMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIV 217 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G +G+APSAN+ + +LFEPVHGSAP I GKNIANP A I Sbjct: 218 TTNLFGDILSDEAAGLIGGLGLAPSANIGEK---NALFEPVHGSAPQIAGKNIANPTAMI 274 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +ML L +Q I A+++ +A G TPD+ G T ++A I + + Sbjct: 275 LTTTLMLKHLNK-----KQEAQKIEKALQKTLAEGLVTPDLGGKLGTMEMAAEIARHLE 328 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 133/356 (37%), Positives = 194/356 (54%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RI I GDGIG EV+P RVL+A G L F + E A E + G +P++ E Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA----TGLPLEFVEAE-AGWETFERRGTSVPEETVE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ A FGA P +G++ RR D Y N+RP + P Sbjct: 58 KILSCHATLFGAATSPTRKVPG--FFGAIRYLRRRLDLYANVRPAKSRP------VPGSR 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D +VRENTEG Y R +V I ++V +++ +RI R A +A+ RPRK Sbjct: 110 PGVDLVIVRENTEGLYVEQERRY-----LDVAIADAVISKKASERIGRAALRIAEGRPRK 164 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 TL A K+N L ++ + + V+ +A+++P + +D + VM+PERFDV+V +N Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GDILSDL G +G+APS N+ ++FEPVHGSAPDI GK IANP A I + Sbjct: 225 LLGDILSDLAAGLVGGLGLAPSGNIGD---TTAVFEPVHGSAPDIAGKGIANPTAAILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMMLD+LG ++A + A++ V+ GP+TPD+ G+ATT +A+ + + Sbjct: 282 AMMLDYLGE-----KEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALK 332 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 170/366 (46%), Gaps = 30/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + GDGIG E++ + VL+ AA L E +E Y ++ + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D Q+ R A+ G V P + R+ Y N+RP + P Sbjct: 57 DTWSQIFRTKALLKGPVTTPQ----GGGYKSLNVTLRKTLGLYANVRPSCSY----FPFV 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +ID ++REN E Y+ + + + +R G ++I+R+AFE A Sbjct: 109 NTSAPEIDVVIIRENEEDLYAGIEY----HHTADTYESVKLISRSGSEKIIRFAFEYALK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RKT++ +K N + + + + +A Y I+ D IDI AR + P++FDV+ Sbjct: 165 NNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDILSD+ +G+IG+A SAN+ + ++FE VHGSAPDI G+NIANP Sbjct: 225 VTSNLYGDILSDIAAKISGSIGLAGSANIGKDY---AMFEAVHGSAPDIAGQNIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + A MML LG + I A+++ I G T D+ T + A A Sbjct: 282 LNAAIMMLVHLG-----LTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQA 336 Query: 355 ICKIIL 360 I + Sbjct: 337 IINNLE 342 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 185/359 (51%), Positives = 233/359 (64%), Gaps = 12/359 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M MR+A IPGDGIG +V E ++V+ +A G + + + ++ SCE Y+ G MMP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA---TGGRIEWTEFDY-SCERYAKTGAMMPP 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L+ FDAI GAVG+P VPD +SLWG L+ RR F+QYVNLRPVRL PG+ PLA Sbjct: 57 DAPTTLAGFDAILLGAVGYP-GVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLA 115 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + +VRENTEGEYS +GG N G ++E +QESVFTR G +RI+RYAFELA S Sbjct: 116 GVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAFELAAS 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + SATKSNG+ SMPYWD +A YP+ H+D L AR V P DV+ Sbjct: 176 AGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPASLDVI 234 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDL A TG +G+A S N+NPERT S+FE VHGSAPDI G+ IANP+A Sbjct: 235 VASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQ 294 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I AGAM+LD L N I A+++V++ G +TPD+ G ATT Q+ AI + Sbjct: 295 ILAGAMLLDHLNE-----PATANKIRLAVDQVLSDGRVRTPDLGGTATTEQLGTAIAEA 348 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 110/359 (30%), Positives = 172/359 (47%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + I GDGIG E+ + AA + +E ++ +PDD Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAA----NAPIKWEPVDVTPI--LKDGKTAIPDDAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G + P L RR F+ + N+RP R G P Sbjct: 108 ESVRRNYVALKGPLATP----VGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---- 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V +G VV + T+ +R+LR+AF+ A+S + Sbjct: 160 -DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITKEASERVLRFAFQYARSINK 214 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 K + K+ + +S + +A+++P++ +D + +D C + V P ++ V+V Sbjct: 215 KKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLV 274 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A + Sbjct: 275 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDE---CSIFEAVHGSAPDIAGKGLANPTALL 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +G + I AI + +A G T D+ G A T + A+AI K + Sbjct: 332 LSSIMMLQHMG-----LHEHAGRIQKAIFDTLAEGKALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 379 bits (974), Expect = e-104, Method: Composition-based stats. Identities = 124/369 (33%), Positives = 181/369 (49%), Gaps = 20/369 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 199 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ GA+G H+ LL+ R + NLRP + P + Sbjct: 200 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLG-GRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D VVRE T G Y G E+ V+ +DRI R AFE Sbjct: 260 TLKKEVAEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFE 319 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 AQ R R L S K+N L SM W +RV AMA YP++ ++D + V P++ Sbjct: 320 TAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQ 377 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FD +V +N+FGDILSD TG+IG+ PSA++ + P LFEP+HGSAPDI G++ AN Sbjct: 378 FDTIVTNNIFGDILSDEASMITGSIGMLPSASVGE--SGPGLFEPIHGSAPDIAGQDKAN 435 Query: 297 PIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGN--ATTPQV 351 P+AT+ + AM+L + LG G+ A I A+ + + G +T D+ G ++ Sbjct: 436 PLATVLSAAMLLRYGLGEGN-----AAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEM 490 Query: 352 ADAICKIIL 360 + + K + Sbjct: 491 GEQVLKAVE 499 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 379 bits (973), Expect = e-103, Method: Composition-based stats. Identities = 117/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ R+++A G + +E + + +PDD E + Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + G + P + + R+ F+ + N+RPVR P VP P G + Sbjct: 79 KRTRVVLKGPLETP----VGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG---RN 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+++ R G V I + + +G ++I+R+AFELA++ RK + Sbjct: 132 IDLVVVRENIEDLYAAIEYRETPG----VTIAHKLISYKGSEKIIRFAFELARAEGRKKV 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T ATKSN L ++ ++ E +A YP+I + ID + V PE+F+V+V +NL Sbjct: 188 TCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLN 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDI+SDL G +G A S N E ++FEPVHG+AP GKN+ NP A I M Sbjct: 248 GDIISDLASGLVGGLGFAASGNYGHE---VAIFEPVHGTAPKYAGKNVINPTAMILTAVM 304 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGN---ATTPQVADAICKIILR 361 ML ++ + I A+ + G T D+ G+ +T DAI + R Sbjct: 305 MLRYIDEFET-----AETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGR 358 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 102/358 (28%), Positives = 165/358 (46%), Gaps = 27/358 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + ++ PG GIG E+ + AA + +E E + G ++ ++ Sbjct: 303 QNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEA-GDLIKEES 357 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G P + R++ + + N+RP R GV P + Sbjct: 358 LNAVINYKWGLKGPFATPI----GKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYS-- 411 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +RENTEGEYS L V G VV + ++ + I RYAFE A+ Sbjct: 412 ---NVDLVTIRENTEGEYSGLEHAVVPG----VVENLKIISQPACENIARYAFEFARKNN 464 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK + + K+ + + + ++ YPEI + ++ ID +C + PE FDV+V Sbjct: 465 RKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEVFDVMVM 524 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDI+SDL G +G+ S N++ +++E VHG+APDI G N ANP A + Sbjct: 525 PNLYGDIVSDLCAGLIGGLGLTASGNISH---TCAVYEAVHGTAPDIAGLNKANPTALLL 581 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 +G MML +G Q+ I A+ + ++ G T D+ G ATT A+ I Sbjct: 582 SGVMMLKAMG-----LQKEGFAIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 376 bits (967), Expect = e-103, Method: Composition-based stats. Identities = 177/359 (49%), Positives = 224/359 (62%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT RIA +PGDGIG++V VL+ A GF+L + W SC+YY +G MMP D Sbjct: 1 MKTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPW-SCDYYLENGSMMPAD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL PGV PL Sbjct: 60 GIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPL-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGR+++G ++EV I+ ++FTR+GV+RILR+ FE A++R Sbjct: 118 -RSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQARAR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L S TKSN SM +WDE ++ YP++ HID + AR VM PE DVV Sbjct: 177 -RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLDVVA 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMML+ LG A ++ AIE A G + G T + ++ + Sbjct: 296 WSGAMMLEHLGET-----AAAEKVMDAIETTTARGV--GAIPGKDRTDAITASVLSALG 347 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 144/359 (40%), Positives = 194/359 (54%), Gaps = 24/359 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +I I GDGIG EV+P VL+A G F + A E + G +P+ Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA----TGLKFEFVEA-QAGWETFERIGTSVPE 55 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E ++ DA FGA P +G++ RR+ D + N+RP + P Sbjct: 56 ATLEAVTHTDATLFGAATSPTKKVPG--FFGAIRYMRRKLDLFANVRPAKHHP------V 107 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D VVRENTEG Y EG E+ I ++V TR+ RI YA LA S Sbjct: 108 PGSRPGVDLIVVRENTEGLYVEQERSYLEG---EIAIADTVITRKASARIGEYAARLAAS 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK L A K+N L ++ + V A A +PE++ ID + V PERFDV+ Sbjct: 165 RPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPERFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDI+SDL G +GIA S N+ + ++FEPVHGSAPDI GK IANP AT Sbjct: 225 VTTNLFGDIISDLTAGLVGGLGIAASGNIGIKH---AVFEPVHGSAPDIAGKGIANPAAT 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 I +G MMLD LG +A + AA+++V+ GP+TPD+ GNATT Q A+A+ + + Sbjct: 282 ILSGVMMLDHLGE-----HEAARRVEAAVDKVLQEGPRTPDLGGNATTLQFAEAVARSL 335 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 175/358 (48%), Gaps = 15/358 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T I A+PGDGIG E+L + +L+ + ++ F E E+ G+ + + Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGAS-IDTFGEPLTEKTL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC--PLAG 121 R DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKA 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++ D +VRE T G Y N + +TR ++RI+ AF+LA SR Sbjct: 121 ERVEGTDLVIVRELTSGIYFGEPRYFNNHE----ALDSLTYTREEIERIVHVAFKLAASR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS K N LA S W + V +++ YPE+ + +D + P++FDV+V Sbjct: 177 -RGKLTSVDKENVLASS-KLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ + + P L+EP+HGSAPDI GKN+ANP I Sbjct: 235 YENLFGDILSDEASVIPGSLGLSPSASFSND--GPRLYEPIHGSAPDIAGKNVANPFGMI 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + AM L A + + I +I HG T D+ G T + + + + + Sbjct: 293 LSLAMCLR----ESLNQPDAADELEQHIYNMIEHGQTTADLGGKLNTTDIFEILSQKL 346 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 116/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG E + ++VL+AA L++E E + + +P + E + Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + G + P + + R+ F+ Y N+RPVR FP VP P AG Sbjct: 78 RKTRVVLKGPLETP----VGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG---RG 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+ + V + + +G ++I+R+AFELA++ RK + Sbjct: 131 IDLVVVRENVEDLYAGIEHMQTPS----VAQTLKLISWKGSEKIVRFAFELARAEGRKKV 186 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 ATKSN + ++ E +A+ YP+I +D + V +PE+F+V+V +N+ Sbjct: 187 HCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMN 246 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSDL G +G APSAN+ E ++FE VHGSAP GKN+ NP A + + M Sbjct: 247 GDILSDLTSGLIGGLGFAPSANIGNE---VAIFEAVHGSAPKYAGKNVINPTAVLLSAVM 303 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVADAICKIILR 361 ML +L + I A+ + G T D+ G A T + +AI + + + Sbjct: 304 MLRYLEEF-----ATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 164/352 (46%), Positives = 224/352 (63%), Gaps = 12/352 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M + +PGDG+G EV+ E + L A +++ + W +++ HG MMP D + Sbjct: 1 MNVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPW-GSAWWAEHGTMMPADAID 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L DAI GAVG P VPD +LWG +LK R+E D +VN+RP RL G+P PLAG+ P Sbjct: 56 VLRGHDAILMGAVGDP-AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAP 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D+D VREN+EGEY+ +GGRV+ G H+V I+ SVFTRRG +R++RYAF +A +R + Sbjct: 115 HDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASAR-KG 173 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L +ATKSN P+WDE V + +P + D+ +D L AR + P DVVVASN Sbjct: 174 VLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVVASN 233 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDIL+D+ A G +G+A SANL+P P+LFEPVHGSAPDI G+ IANP+ IW+ Sbjct: 234 LFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSA 293 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A+ML+ LG G+ ++ A+E V GP+T D+ G ATT +V DA+ Sbjct: 294 ALMLEQLGAGEG-----SRRLMDALETVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 118/358 (32%), Positives = 182/358 (50%), Gaps = 23/358 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K R+A I GDG+G +V+ + VL A +++ + + A +G +P + Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPA-VAGLNTVEKYGTNLPKET 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L D + G P+ SL + + R+ FD Y ++RP + P VP Sbjct: 63 LDTLKETDCVLKGPTTTPE---GANSLPSANVGIRKYFDLYADVRPNKTLPNVPS----- 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +VRENTEG YS L RVN E I V TR+ +RI++YAF+LA+SR Sbjct: 115 IKPNVDMVIVRENTEGMYSGLDFRVN----QETTIGIRVITRKACERIVKYAFKLAESR- 169 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +K +T K N L +S + + A+ +P+++ D H+D + F+ QPE +DV+V Sbjct: 170 KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFYDVIVT 229 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI+SD G IG SAN+ + ++FEP+HGS P G + NPI TI Sbjct: 230 ENLFGDIISDEAAMVVGGIGTGASANIGDKY---AMFEPIHGSVPKYTGMDKVNPIGTIM 286 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 + MMLD++ ++A I A+ +V+ G T D+ G A +V I + Sbjct: 287 SVKMMLDWMDY-----KEAGKAIEDAVYKVLEEGKILTYDLGGTAKCSEVGKEIASKV 339 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 106/366 (28%), Positives = 164/366 (44%), Gaps = 30/366 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK + I GDGIG E++ ++V+ A G L E++E Y + + Sbjct: 1 MKKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVYSMGNPSGIEPS 56 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L R + P + R+ Y N+RP + P Sbjct: 57 SWESLKRTKVFLKAPITTPQ----GGGFKSLNVTVRKALGLYANIRPCISY----APFIH 108 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + ID ++REN E Y + R + + TR+G +RI+RYAFE A+ Sbjct: 109 TKHPGIDLVIIRENEEDLYGGIEHRQGV----DSFQALKIMTRQGTERIIRYAFEYARCY 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK ++S TK N L I+ + + E +A+ YP+I + IDI A+ P+ FDV+V Sbjct: 165 GRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQSFDVLV 224 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NL+GDILSD+ G++G+ SAN+ E S+FE +HGSAP G+N+ANP + Sbjct: 225 LANLYGDILSDVAVQIAGSVGLGASANIGHEY---SMFEAIHGSAPRRAGQNVANPSGLL 281 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAI 355 A ML +G + + A + I G T D+ T + A + Sbjct: 282 LAAVQMLIHIGQ-----NAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREFARHV 336 Query: 356 CKIILR 361 K + + Sbjct: 337 IKNLGK 342 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 179/322 (55%), Positives = 212/322 (65%), Gaps = 6/322 (1%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT +A IPGDGIG +V + VL AAA + FA W SCEYY HG+MMP+D Sbjct: 1 MKTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPW-SCEYYLEHGRMMPED 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAIY GAVGWP TVPD +SL G LL R+ F+QY N+RP RL GV PL Sbjct: 59 GIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV+EG +EV ++ SVFTR GV+RILR+ FE A+SR Sbjct: 118 --AEGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQARSR 175 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS TKSN SM +WDE +A YP++ HID + A+ VM P+ DVVV Sbjct: 176 -RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLDVVV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI GKNIANPIA I Sbjct: 235 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHN 323 W+ A MLD LG + Sbjct: 295 WSVAQMLDHLGEAEVSAAVLSA 316 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 125/366 (34%), Positives = 192/366 (52%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA +PGDGIG EV+ E ++VL+ ++ G + G+ +P++ + Sbjct: 1 MKIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGG-DAIDRFGEPLPEETKK 59 Query: 65 QLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 DAI+ G+VG P P+ G LL R+ + Y N+RP++++ + PL Sbjct: 60 ICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPL 119 Query: 120 AGKQPG-DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 K G +D VRE + G Y G + E ++ R+ V+RI R AFE+A Sbjct: 120 KEKVIGSGVDLVTVRELSYGVYYGQP----RGLDEEKGFDTMIYDRKTVERIARTAFEIA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R RK +TS K+N L SM W + V +A YP++ ++D + +++P +FD Sbjct: 176 KNR-RKKVTSVDKANVLYSSM-LWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ +N+FGDILSD A G++G+ PSA+ + L+EP GSAPDI GKNIANPI Sbjct: 234 VILTTNMFGDILSDESAALPGSLGLLPSASFGDKN----LYEPAGGSAPDIAGKNIANPI 289 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK----GNATTPQVADA 354 A I + AMML+ + I A+E VI G +T D+ +T Q+ D Sbjct: 290 AQILSLAMMLEH----SFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDL 345 Query: 355 ICKIIL 360 ICK + Sbjct: 346 ICKKLE 351 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 107/367 (29%), Positives = 170/367 (46%), Gaps = 30/367 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + I GDGIG E++ + +L+ A R + E +E Y H+ + + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E + R I + P + R+ + N+RP F P Sbjct: 57 QSWESIERTGVILKAPITTPQ----GGGYKSLNVTIRKTLQLFANIRPSVSFY----PFT 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +++ ++REN E Y+ + R H + + +R G ++I+RYAFE A Sbjct: 109 KTLHPNLNLTIIRENEEDLYAGIEYRQ----THNMYESVKLISRTGCEKIIRYAFEYAVK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T +K N + S + + +A+ YP+I + IDI AR +PE FDV+ Sbjct: 165 NNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDI+SD+ +G++G+A SAN+ ++FE VHGSAPDI G++IANP Sbjct: 225 VTSNLYGDIISDVAAEISGSVGLAGSANIGEHY---AMFEAVHGSAPDIAGQDIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADA 354 + A MML +G GD I A ++ I G T D+ T + A+ Sbjct: 282 LNAAIMMLVHIGQGD-----IATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAEE 336 Query: 355 ICKIILR 361 + K + + Sbjct: 337 VVKRLGQ 343 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 121/360 (33%), Positives = 181/360 (50%), Gaps = 19/360 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M++A +PGDGIG EV ++VL+A E G L++E + G+ P+ + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGG-AAIDAFGEPFPEPTRK 59 Query: 65 QLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 + +A+ G+VG P P I LL R+ D + NLRP ++FPG+ PL Sbjct: 60 GVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D +VRE T G Y G +++ V+R+ R AFE A+ Sbjct: 120 EEIARGVDVLIVRELTGGIYFGEP----RGMSEAEAWNTERYSKPEVERVARVAFEAARK 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R RK + S K+N L + +W + VE + YP++ + Q++D + V P RFDVV Sbjct: 176 R-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVV 233 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V N+FGDILSDL G++G+ PSA+L +FEPVHGSAPDI GK IANP A Sbjct: 234 VTGNIFGDILSDLASVLPGSLGLLPSASLG---RGTPVFEPVHGSAPDIAGKGIANPTAA 290 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 I + AMML+ + + A+ + + P PD+ G+A T + + + Sbjct: 291 ILSAAMMLEHA----FGLVELARKVEDAVAKALLETP-PPDLGGSAGTEAFTATVLRHLA 345 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 123/367 (33%), Positives = 175/367 (47%), Gaps = 21/367 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA + GDGIG EV+ E +VL A ++ F ++ + + +HG +PD Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGG-AAIDNHGNALPDSTMAG 61 Query: 66 LSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL--- 119 DAI FG+VG P P +LL R FD + N+RP L P + Sbjct: 62 CIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLR 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + D V+RE T Y E E ++RR V RI AF+ AQ Sbjct: 122 SDISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQ 181 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R +TS K+N LA S W + VE +A YP++ + ++D + V P +FDV Sbjct: 182 KRN-NKVTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 ++ NLFGDILSD+ TG++G+ PSA+LN + ++EP GSAPDI G +ANPIA Sbjct: 240 MLCPNLFGDILSDICAMITGSMGLLPSASLNSD--GFGMYEPAGGSAPDIAGLGVANPIA 297 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVAD 353 I + A+ML + A I A+ + +G T D+ K +T +V D Sbjct: 298 QILSAALMLRY----SLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGD 353 Query: 354 AICKIIL 360 ICK I Sbjct: 354 YICKQIE 360 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 159/356 (44%), Positives = 226/356 (63%), Gaps = 15/356 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +I IPGDGIG EV+ E ++ Q+ + + ++W ++Y GK++P D+ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL----NLPIQRDYVDW-GIQHYLKTGKVVPIDYI 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 +Q+ ++DAI G++G P T+PD+++L L++ R++ DQ++ LRP + FPG+P PL Sbjct: 65 DQVKQYDAILLGSLGDPRTLPDYVTLE-PLIQMRQQLDQFLCLRPAKHFPGIPTPLKKC- 122 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +ID VVREN+EGEYS++GG GT E I+ +V TRRG++R++RYAFE ++ R R Sbjct: 123 --EIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEASRKR-R 179 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T ATKSN + M WD EA+A YP++ +K ++D L A V P +FDV+V S Sbjct: 180 NHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGS 239 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLF DI+SDL G++GIAPSAN+NPERTFPSLFEPVHGSA DI GK I +PI T+ A Sbjct: 240 NLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRA 299 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +MML+FLG +E I AI+ I T D+ G TT +V + I I Sbjct: 300 SSMMLEFLGYSEESV-----LIEEAIQSSILQKITTIDIGGTKTTNEVGNFIADYI 350 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 102/364 (28%), Positives = 167/364 (45%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG E+ + +L AA G L E +E Y + +P + Sbjct: 20 TPIPVTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEA 75 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + ++R + G + P + R+ Y N+RP R + P+ Sbjct: 76 WDSIARTRVMLKGPITTPQ----GGGYKSLNVTMRKTLGLYANVRPCRTYK----PIVTT 127 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + D+D +VREN E Y+ + R +V + TR G +RI RYAFE A+ Sbjct: 128 RHPDMDVVIVRENEEDLYAGIEHRQ----TQDVAQCLKLITRSGSERIARYAFEYARQHG 183 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T K N + ++ + + +A YPEI+ Q +D A FV +PE +DVV+ Sbjct: 184 RSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVLL 243 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDILSD+ TG++G+ S N+ + ++FE +HGSAPD+ +++ANP + Sbjct: 244 PNLYGDILSDIAAQMTGSVGLGGSVNIG---SGGAIFEAIHGSAPDLA-RDVANPSGLLL 299 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG-----NATTPQVADAICK 357 A ML L + ++ A + G T D+ G A T + +A+ + Sbjct: 300 AAVEMLRHL-----KLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVIE 354 Query: 358 IILR 361 + R Sbjct: 355 RLGR 358 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 135/371 (36%), Positives = 188/371 (50%), Gaps = 29/371 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 I IPGDGIG+EV+P + VL+A G FE + A E + G+ +P Sbjct: 4 APYTILVIPGDGIGREVIPAAVAVLRA----TGLPFHFENAD-AGWECFQRQGEALPSAT 58 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI FGAV P +++ RRE D Y N+RPV F +P + Sbjct: 59 LTAARAADAILFGAVASPGYPVAG--YRSPIVRLRRELDLYANIRPV--FDDLPENGSNP 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR- 181 + +D VVRENTE Y+ ++G I E V TRR RI+R A +LA++R Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGAT---AIAERVITRRASARIMRVACDLARARR 171 Query: 182 --------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 P +T K+N L + + +A+ YP+++ D+ +D + + Sbjct: 172 SARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATR 231 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 PERFDV+V +NLFGDILSD+ A G +G+APSANL +LFEPVHG+APDI GK Sbjct: 232 PERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH---ALFEPVHGAAPDIAGKG 288 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAH-----NGILAAIEEVIAHGPKTPDMKGNATT 348 IANP+A I A++LD L + I AI V A GP TPD+ G+A T Sbjct: 289 IANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVT 348 Query: 349 PQVADAICKII 359 + +A+ + Sbjct: 349 TDITNAVLSHM 359 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 186/355 (52%), Gaps = 29/355 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A I GDGIG+E++P ++VL A +G +E + G + ++ E Sbjct: 1 MRLAVIEGDGIGREIIPAAVKVLDA----FGLEFEKVPLEL-GYTRWERTGTAISNNDLE 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA+ FGA+ + LL R+E D Y N+RPV+ PG+ Sbjct: 56 TIKGCDAVLFGAITT----VPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGV---TGR 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D DF +VRENTEG YS + E+ + V TR+G +RI YA +LA+ R + Sbjct: 109 NDFDFIIVRENTEGLYSGIE-----EIGPELSWTKRVVTRKGSERIAEYACKLAKKR-KN 162 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT KSN L S + + A + ++ +D + +M+PER+D+VV +N Sbjct: 163 KLTIVHKSNVLK-SDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVTTN 220 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSD+ A G++G+ PSAN+ + + FEPVHGSAPDI GK IANP+A I Sbjct: 221 LFGDILSDMCAALVGSLGLVPSANIGEKY---AFFEPVHGSAPDIAGKGIANPLAAILCV 277 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L+++G I AI V+ TPD+ G A+T +V +A+ + + Sbjct: 278 KMLLEWMGEPR------SQIIDEAIAYVLQKKIITPDLGGTASTMEVGNAVAEYV 326 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 123/364 (33%), Positives = 183/364 (50%), Gaps = 18/364 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I IPGDGIGKE+ + VL+ E++G LS+ + Y G +PDD Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKDAGGTAY-DKFGTPLPDDTI 60 Query: 64 EQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 E D + FGAVG + ++L R+ Y NLRPV++ + PL Sbjct: 61 EACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +D +VRE G Y + E ++ VDRI + AFE A+ Sbjct: 121 KPELVKGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETAK 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R +TS K+N LA S W V +AE+YP++ + ++D + ++P +FDV Sbjct: 181 LR-RGKVTSVDKANVLATSR-LWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDV 238 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V NLFGDILSD G+IG+ PSA++ T SL+EP+HGSAPDI GK IANP+ Sbjct: 239 IVTGNLFGDILSDEAAVVGGSIGMMPSASIG---TSTSLYEPIHGSAPDIAGKGIANPMG 295 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAI 355 TI + AM+L + + + + + A +A G +TPD+ A T ++ I Sbjct: 296 TILSAAMLLRYSLHEEAAAKAIEAAVDKA----LADGYRTPDLWKEGFQKANTEEITKVI 351 Query: 356 CKII 359 C+ I Sbjct: 352 CERI 355 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 179/367 (48%), Gaps = 18/367 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDGIG EV+ VLQ A G F++M G +P++ Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGG-AALDLVGVPLPEET 103 Query: 63 HEQLSRFDAIYFGAVGWPDTVP--DHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 DAI GA+G H+ +L RR+ + NLRP + P + Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDAST 163 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVN-EGTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + EV + ++ +DRI R AFE Sbjct: 164 LKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFET 223 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R R L S K+N L S+ W +RV A+A YP++ ++D + + P++F Sbjct: 224 ARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +N+FGDILSD TG+IG+ PSA+L + P LFEP+HGSAPDI G++ ANP Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGE--SGPGLFEPIHGSAPDIAGQDKANP 339 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVAD 353 +ATI + AM+L + ++A I A+ + + G +T D+ ++ + Sbjct: 340 LATILSAAMLLKY----GLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGE 395 Query: 354 AICKIIL 360 + K + Sbjct: 396 EVLKSVE 402 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 365 bits (937), Expect = 1e-99, Method: Composition-based stats. Identities = 121/363 (33%), Positives = 184/363 (50%), Gaps = 13/363 (3%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T+ IA +PGDGIG+EV+P + ++ AA G Q A +YY+ G +P Sbjct: 7 TLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPASTL 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + + DAI FGA+GWPD + L R E + +RP+R FPG+P L + Sbjct: 67 DACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPR 126 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 IDF +VRE TEG + + G E E TR G R+ +AF++A+ R R Sbjct: 127 AEQIDFVLVREQTEGLFYARGR--GEIRNDEEAYDTMQITRSGTQRVTEFAFDIARQRKR 184 Query: 184 K----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + +T K+N SM ++ + + +A+ + ++ D ++D L V +P FDV Sbjct: 185 RGKPGNVTCVDKANVF-QSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKPWTFDV 243 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+APSA++ + LF+P HG+APDI GK ANP A Sbjct: 244 LVTENMFGDILSDLAAGLIGGMGMAPSADIGDKH---GLFQPAHGTAPDIAGKGCANPSA 300 Query: 300 TIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAIC 356 + AMMLD+L A + A+E ++ P + GNA ++ ++ Sbjct: 301 MFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPMEYGGNANCAEMTRSVI 360 Query: 357 KII 359 + Sbjct: 361 SSL 363 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 365 bits (937), Expect = 1e-99, Method: Composition-based stats. Identities = 155/384 (40%), Positives = 219/384 (57%), Gaps = 32/384 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ I GDGIG EV+ EG +V+ AA E + F + + M + S ++Y G+ + + Sbjct: 1 MVSYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPF-SADHYVKTGETISES 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++LS++ AI+ G++G V + G LL R +DQYVNLRPV+L GV PL G Sbjct: 60 SLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-----------------------HEVVIQ 158 K DIDFYVVRENTE Y +GGR +GT E+ Q Sbjct: 120 KTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQ 179 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 V ++ G RI+ Y+F+LA SRP+K L+S K+N L +W E A YP+++ Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 D ++D + FV PE FDVVV+ N+FGDI++DLG G +G+AP N+NPE S+ Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPE--GTSM 297 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GP 337 FEP+ GSAP G N NPIATIWAGAM+L+ LG +QA GI+ AIE+ + Sbjct: 298 FEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGE-----KQAAAGIVDAIEQNLKEKKI 352 Query: 338 KTPDMKGNATTPQVADAICKIILR 361 +T D+ G+A T V I +I+ + Sbjct: 353 RTYDLGGSAGTSDVGTDIARIVKQ 376 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 365 bits (937), Expect = 2e-99, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 160/355 (45%), Gaps = 13/355 (3%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI + GDG+G EV+ VL +G + + G+ +P Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGV-AIDLTGQPLPQRTLAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 DA+ GAVG P LL R+ + N+RPV + K Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +IDF VVRE T G Y S EV + R ++RI+ YAF+LA R +K Sbjct: 123 EIDFVVVRELTGGIYFSYPKER----TEEVATDTLTYHRHEIERIVSYAFQLANKR-KKK 177 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +TS K+N L S W E +A YP + + +D + P RFDV+V NL Sbjct: 178 VTSIDKANVLESS-KLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTENL 236 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSD G++G+ PSA+ PSL+EP+HGSAPDI GKN ANPIA + + A Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAE--KGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML + I A+ V+ G T D+ G TT A+ + + Sbjct: 295 MML----GQSFGLTREGYAIEEAVSAVLKSGKCTADIGGTETTTSFTKAVIQEME 345 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 104/361 (28%), Positives = 170/361 (47%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDGIG E+ ++ AA + +E + + + + +PD Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAA----NVPIEWESCDVSPI--FVNGLTTIPDPAV 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + +++ G + P L R+ F + N+RP + G Sbjct: 90 QSITKNLVALKGPLATPI----GKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---- 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V G VV + TR +R++RYAFE A++ R Sbjct: 142 -ENVDLVLIRENTEGEYSGIEHIVCPG----VVQSIKLITRDASERVIRYAFEYARAIGR 196 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 + KS ++ + + +++ YP++ + + ID + V P + V V Sbjct: 197 PRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSV 256 Query: 242 ASNLFGDILSDLGPAC-TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 NL+GDILSDL G++G+ PSAN+ + S+FE VHGSAPDI G++ ANP A Sbjct: 257 CPNLYGDILSDLNSGLSAGSLGLTPSANIGHK---ISIFEAVHGSAPDIAGQDKANPTAL 313 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP--KTPDMKGNATTPQVADAICKI 358 + + MML+ +G + I A+ IA GP +T D+ G ATT +A+ K Sbjct: 314 LLSSVMMLNHMG-----LTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKR 368 Query: 359 I 359 + Sbjct: 369 L 369 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 364 bits (934), Expect = 3e-99, Method: Composition-based stats. Identities = 151/359 (42%), Positives = 208/359 (57%), Gaps = 11/359 (3%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +R+A IPGDGIG EV+ + L+AA E G L +W E Y G MP D Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGG-ERYLRQGAAMPPDA 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + DA+ FGAVG PD VP+H +WG ++ R++ D VNLRPVR FPGVP + Sbjct: 65 ADLVKKTDAVLFGAVGRPD-VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +VRENTEGEY GG + G+ H++ I+ +V +RR ++R AF LA R Sbjct: 124 --DGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFALAGRRS 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L TKSN + P WD V + E YP + + +D + AR + P DV++A Sbjct: 182 -GRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLA 240 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDL G +G+APSAN+ P+ P ++EPVHGSAPDI GK +ANP+A + Sbjct: 241 SNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIIL 360 +GAM+L+ LG+ D A + A+ + + T D+ GNATT VA A+ + Sbjct: 301 SGAMLLEDLGHTD-----AARRVRDAVADTLRDTRHHTADLGGNATTADVASAVLHTME 354 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 360 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 163/358 (45%), Positives = 211/358 (58%), Gaps = 10/358 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+++A IPGDGIG EV+ EG++VL A A R G L + E + + G+++PD Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYEL-GAQRWHATGEVLPDAV 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L + DAI GAVG P VP + G LL+ R F YVNLRPVRL+PGV PLAG Sbjct: 63 EEELRQHDAILLGAVGDPT-VPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGV 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 P DID VVRE TEG Y+ +GG + +GT HE+ Q+SV TR GV+R++RYAF A RP Sbjct: 122 APEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERP 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 LT K N L + W V + YP++ D H+D FV QP RFDVVV Sbjct: 182 CHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVT 241 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI++DLG A G IG+A S N+NPE FPS+FEPVHGSAPDI G+ A+P ATI Sbjct: 242 DNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + ++ML+ LG D Q E G + +T Q+ D I + + Sbjct: 302 SVSLMLEHLGYADAAAQIDQAVAEDLQERAKNGGVR--------STTQIGDDIAQRVA 351 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 106/350 (30%), Positives = 168/350 (48%), Gaps = 15/350 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I A+PGDGIG E+L + +L+ +E++ F E + ++G + ++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVS-IDYYGTPLTNETL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAG 121 + DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 QSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQ 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +VRE T G Y V + + ++ + ++RI+R AF LA R Sbjct: 121 DIVEGTDLVIVRELTSGIYFGEPSYVKKTE----ALDSLKYSSQEIERIVRIAFNLANRR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK LTS K N L S W + V + ++YPE+ + +D + QP +FDV+V Sbjct: 177 -RKKLTSVDKENVL-SSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ +T L+EP+HGSAPDI ++ ANP + Sbjct: 235 TENLFGDILSDEASVIPGSLGLSPSASFG--QTGTRLYEPIHGSAPDIANEDKANPFGMV 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 + A+ L A N + + + I T D+ G T ++ Sbjct: 293 LSLALCLR----ESLNQNDAANELESIVYSFIQSNKTTADLGGQYRTSEI 338 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 356 bits (914), Expect = 6e-97, Method: Composition-based stats. Identities = 117/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M IA +PGDGIG E + ++L +++ + + + + + G P Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGG-DAINSEGTPFPK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 + + +AI FGAVG P G+LL R+ F+ + NLRP+ L + Sbjct: 60 STLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKE 119 Query: 117 -CPLA-GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL P ID VRE T G Y + +E +V+ R ++RI A Sbjct: 120 LSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LAQ R RK ++S K+N L SM W E V +A+NYP++ + +ID + + P Sbjct: 180 FKLAQKR-RKRVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNASMQLINNP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 +FD+++ NLFGDILSD +G+IG+ PSA++N L+EP GSAPDI KNI Sbjct: 238 SKFDIILCPNLFGDILSDECAMISGSIGMLPSASINEH--NFGLYEPAGGSAPDIAEKNI 295 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----TTPQ 350 ANPIA I + A++ + + I A+ + + G +T D+ +T + Sbjct: 296 ANPIAHILSIALLFRY----SLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNE 351 Query: 351 VADAICKIIL 360 + D I +I Sbjct: 352 MGDIIAALIK 361 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 356 bits (913), Expect = 9e-97, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 170/366 (46%), Gaps = 15/366 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ + GDGIG E+ + VLQAA + + ++ E H + Sbjct: 1 MSNLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEI-GFASLKKHKTTFRSE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + D + G D P R+ FD Y N+RP + G Sbjct: 60 VLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 P ID V+RENTEG YS G +V I TR+G RI F+ A Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAEIGFKYA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R RK L + K+N L S + E +++ YPE+ + +Q +D + A + P FD Sbjct: 176 MER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRDPSVFD 234 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++A+NLFGD LSD G +G+A S N + + HGSAPDI GKNIANP+ Sbjct: 235 VILATNLFGDNLSDAASEIAGGLGLAESINAGENY---CIAQAQHGSAPDIAGKNIANPV 291 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAI 355 + I + AMMLD+LG +++ ++ I AI++ I + +T D+ GN +T D + Sbjct: 292 SLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDIGGNLSTTDFTDVL 351 Query: 356 CKIILR 361 + + Sbjct: 352 ISNLKK 357 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 131/368 (35%), Positives = 194/368 (52%), Gaps = 29/368 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K++ I IPGDGIGKEV+P G +VL+ + G + +F +A + + GK +PD+ Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFID-LYAGFQTFQETGKALPDET 80 Query: 63 HEQLSR-FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L FGAV P T + ++ RRE + N+RPV+ G Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKVEG--YSSPIVALRREMGLFANVRPVKSVEG------- 131 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ ID +VRENTE Y + +++ T V + RI A ++A Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191 Query: 181 R----PRKTLTSATKSNGLAISMPYWDERVEAMAE----NYPEIRWDKQHIDILCARFVM 232 R + TLT KSN L+ S + E + + E Y +I++++Q +D + R Sbjct: 192 RLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFR 251 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 +P+ FDV+VA NL+GDILSD A G++G+ PSAN+ PE + EP HGSAPDI GK Sbjct: 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGK 308 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQV 351 IANPIATI + A+ML+FLG+ +A I A++ + G KTPD+ G A+T QV Sbjct: 309 GIANPIATIRSTALMLEFLGH-----NEAAQDIYKAVDANLREGSIKTPDLGGKASTQQV 363 Query: 352 ADAICKII 359 D + + Sbjct: 364 VDDVLSRL 371 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 120/366 (32%), Positives = 193/366 (52%), Gaps = 22/366 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK I I GDGIG EV+ + I+ L + R+ S++ + A + G MP + Sbjct: 1 MKK-NIVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNV-LAGAKAIETFGDPMPKE 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-PCP 118 + + DA+ FG++G P P + LLK R+E D Y N+RP+ +PG+ P Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSP 118 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + ++ ++F + RE T G Y GR G E V++ + ++RI +F+ A Sbjct: 119 IKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSFKAA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +SR RK +T K+N L S W E ++ MA +Y ++ + +ID + ++ P +FD Sbjct: 176 RSRNRK-MTLVDKANVLETSR-LWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ N+FGDILSD T ++G+ PSA++ ++ SLFEP+HGS P GKNIANP+ Sbjct: 234 VILTDNMFGDILSDEASILTSSLGLLPSASIGSKK---SLFEPIHGSYPQAKGKNIANPL 290 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 I + +MML++ Q N + A++ I TPD+ + +++T +V D Sbjct: 291 GCILSVSMMLEYF-----EMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDY 345 Query: 355 ICKIIL 360 I K I Sbjct: 346 IEKYIK 351 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 129/359 (35%), Positives = 185/359 (51%), Gaps = 33/359 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQ-MEWASCEYYSHHGKMMPDD 61 +IA IPGDGIGKEV+ I VL + F+ A E HG +P + Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDE------LDVDFDYIYGIAGDECNEEHGTPLPQE 62 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + DA FGA G + ++K R+E + NLRPV+ +P Sbjct: 63 TIDIVRDSDACLFGAAG--------ETAADVIVKIRQEMKMFANLRPVKSYPNTKSL--- 111 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++DF +VRENTEG Y + E + I + V TR +RI+ YAF+ A+ Sbjct: 112 --FENVDFMIVRENTEGLYIA----DQEEETEDGAIAKRVITREAEERIIDYAFQYAKDN 165 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R +T+ K+N L + + + + E YP+I + ++D V QP+ F VVV Sbjct: 166 NRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQVVV 225 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G G +G+ PSAN+ + +LFEPVHGSAPDI G+ ANPIA + Sbjct: 226 TTNLFGDILSDEGAGLVGGLGLIPSANIGADG---ALFEPVHGSAPDIAGQQKANPIAMM 282 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +LG D A + AAI +V++ G T D+ G+ATT +VA A+ + Sbjct: 283 LSAIMMLRYLGEND-----AADKFDAAILKVLSEGKTLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 113/370 (30%), Positives = 175/370 (47%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ +PGDGIG E + E +V+ E+ C Y HG+ + D Sbjct: 1 MASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAY-DAHGQAISDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E+ D++ FGAVG P P + LL+ R++ Y NLRP +P + Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA++R R +TS K N + + + E + +++ + D + V P++ Sbjct: 180 LARTR-RNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV++ NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + AAI V+ G +T D+ T Sbjct: 299 GIANPIAMIASLAMCLRY----SFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGT 354 Query: 349 PQVADAICKI 358 ++ DAI Sbjct: 355 TEMGDAILAK 364 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 355 bits (911), Expect = 2e-96, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 166/360 (46%), Gaps = 30/360 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + IPGDGIG V +V++A + FE+ E +P++ Sbjct: 37 APRTVTLIPGDGIGPLVTGAVEQVMEAM----HAPVHFERYEVLGNMRK------VPEEV 86 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E + R G + P + ++ R+E D + +L PG+ Sbjct: 87 IESVKRNKVCLKGGLATP----VGGGVSSLNMQLRKELDIFASLVNCINVPGLVT----- 137 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + ++D V+RENTEGEYS L V G VV V T+ +RI RYAFE A Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITKFCSERIARYAFEYAYLNN 193 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T+ K+N + ++ + E +A++Y I +++ +D C + V +PE+FDV+V Sbjct: 194 RKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVT 253 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD-IYGKNIANPIATI 301 NL+G+++++ G G+ P N+ E D + + ANP+A + Sbjct: 254 PNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALL 313 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + AMML L RF + + A+++VI G +T D+ G+ TT +V DA+ + Sbjct: 314 LSSAMMLRHL-----RFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 355 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 116/365 (31%), Positives = 178/365 (48%), Gaps = 28/365 (7%) Query: 1 MMKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M +T +I IPGDGIG E++ + VL A G ++ +A + G + Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL----GSPFEWDSQ-YAGMAAIARVGDPL 61 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P + + + G + P ++ R+EF+ + N+RP Sbjct: 62 PRETIQSIHHNKLALKGPLTTP----TGGGYRSVNVQLRKEFELFANVRPALTL------ 111 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-EHEVVIQESVFTRRGVDRILRYAFEL 177 + G + ++D ++REN +G Y++ + G H V + TR G RI+RYAFE Sbjct: 112 IPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPER 236 A RK +T K+N L + E + +A+ Y I ++++ +D + V+ P R Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLVLDPGR 231 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V +NLFGDILSDL G +G+AP N+ ++FE VHGSAPDI GK IAN Sbjct: 232 FDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIG---KQAAIFEAVHGSAPDIAGKGIAN 288 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE-EVIAHGPKTPDMKGNATTPQVADAI 355 P+A + A AMMLD +G D + AI + G +TPD+ G A T ++ A+ Sbjct: 289 PLALMLAAAMMLDHVGKTD-----LATRLRNAIRITTLEDGIRTPDLGGTAKTRELTQAL 343 Query: 356 CKIIL 360 I Sbjct: 344 ISRIG 348 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 97/363 (26%), Positives = 161/363 (44%), Gaps = 33/363 (9%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++ GDG+G E++ + ++ A G + + +E Y + D E Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L R + + P + + R++ + N+RP + Q Sbjct: 58 TLKRNKVLLKAPITTPR----GGGVRSLNVTLRKKLGLFANIRPCKS-------HLEWQD 106 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D ++REN E YS + R T + V T +RI RYAFE A+S RK Sbjct: 107 PKMDIVIIRENEEDLYSGIEYRQTLDTYN----CTKVITESTSERICRYAFEYARSNGRK 162 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K N + ++ + + + +A YP+I + IDI AR PE+FDV+V N Sbjct: 163 KVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLN 222 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDI+SD+ +G++G+ S N+ E ++FE VHGSAPDI ++IANP + A Sbjct: 223 LYGDIISDIAAEISGSVGLGGSINIGEEY---AMFEAVHGSAPDIADQDIANPSGLLNAA 279 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKI 358 ML ++G ++ + +A + + G T D+ T + + I Sbjct: 280 MYMLSYIGQ-----KEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHN 334 Query: 359 ILR 361 I R Sbjct: 335 IDR 337 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 354 bits (908), Expect = 4e-96, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 67 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 119 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 120 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 175 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 176 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 235 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 236 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 292 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + I + I Sbjct: 293 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIR 346 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 353 bits (905), Expect = 8e-96, Method: Composition-based stats. Identities = 115/364 (31%), Positives = 186/364 (51%), Gaps = 12/364 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M ++ + + GDGIG EV + +R+L+ G ++ EY G+ +P Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEY-QRSGEALP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ DA+ GA+G P+ + L R Y +RP+RL+ PL Sbjct: 60 QSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPL 119 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G PG+IDF +VRE+TEG + E + TR +R+ R AFE A+ Sbjct: 120 KGHGPGEIDFVLVRESTEGLFYGRD--AIADLEADEATNLLRITRSASERVCRLAFETAR 177 Query: 180 SR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +KT+T K+N L SM Y+ + +A+ + +I+ + ++D V +P+ FD Sbjct: 178 RRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFD 236 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APS ++ + ++F+P HGSAPDI G++IANPI Sbjct: 237 VMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDD---AAVFQPSHGSAPDIAGQSIANPI 293 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICK 357 A + AMML++L + + R +V++ +T DM GN +T ++ D I + Sbjct: 294 AMHLSTAMMLEWLDHPETRRAADALNAAI--ADVLSDPTQRTADMGGNLSTVEITDKIAE 351 Query: 358 IILR 361 + + Sbjct: 352 RLSK 355 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 352 bits (904), Expect = 9e-96, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 168/370 (45%), Gaps = 18/370 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMP 59 M +I +PGD +G+E+ E I+VL+A ++ R FE G +P Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGG-AAIDATGVPLP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 D+ E + DA+ GAVG P + LLK R+E Y NLRP Sbjct: 60 DEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDL 119 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P+ + DF VVRE G Y V +T V RI R A Sbjct: 120 SPIKPQFAKGTDFVVVRELVGGIYFGKRKE---DDGDGVAWDSEQYTVPEVQRITRMAAF 176 Query: 177 LAQSR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +A P + S K+N LA S + E + +P ++ Q ID V P Sbjct: 177 MALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPT 236 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 + +++ SN+FGDI+SD G++G+ PSA+L + T L+EP HGSAPD+ Sbjct: 237 HLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-P 295 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 KN NPIATI + AMML + I A+++V+ G +T D+ G+ +T +V Sbjct: 296 KNKVNPIATILSAAMML----KLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEV 351 Query: 352 ADAICKIILR 361 DA+ + + + Sbjct: 352 GDAVAEEVKK 361 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 101/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 104 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 105 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 157 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 213 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 214 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 273 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 274 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 330 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + + + I Sbjct: 331 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIR 384 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 96/358 (26%), Positives = 167/358 (46%), Gaps = 25/358 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK-MMPDDWHE 64 + IPGDGIG E++ + + G + FE++ + + ++ Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFRHI----GVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + R G + P L+ R D + N+ + PG+ + Sbjct: 108 SIKRNGVAMKGNIFTPLDAIPG--FRSLNLELRVHLDLFANIVRCKSIPGIQT-----RH 160 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ++D ++R+NTEGEYS L G V+ V T +I +YAF+ A+ RK Sbjct: 161 NNVDLVIIRQNTEGEYSHLEHENVSG----VIENLKVTTEEACMKIAQYAFDFAEKHDRK 216 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K+N + + + E M+ +YP I ++ ID C + V P++FDV+V N Sbjct: 217 KVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLPN 276 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIWA 303 L+G+I+S++G + G GI P N+ + ++FE + DI GK+I+NPI+ ++A Sbjct: 277 LYGNIVSNIGASLVGGPGIVPGENIGGDY---AIFESGSRHTGLDIQGKDISNPISMLFA 333 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 +ML+ L F + I +AI +V+ G T D+ G+ TT Q A+ + + Sbjct: 334 STLMLEHL-----EFTAYADLINSAILKVVQRGVLTADVGGSHTTTQFLSALKSELDQ 386 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 350 bits (899), Expect = 4e-95, Method: Composition-based stats. Identities = 113/365 (30%), Positives = 173/365 (47%), Gaps = 14/365 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K +A + GDGIG E++P +++L AA G +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L D G + S R+ F + N+RP + F G Sbjct: 81 TLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG-----GN 135 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 D +VRENTEG Y+ G +V I + TR +RI AF+LA Sbjct: 136 AIVEGTDLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAHEAFQLA 195 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R K +T K+N L ++ + + + + YP++ + HID V + ++FD Sbjct: 196 RTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVRRADKFD 254 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G++GIAPS N + ++ + HGSAPDI G++IANPI Sbjct: 255 VIVTENMFGDILSDLAGEVAGSLGIAPSINSSATH---AMAQASHGSAPDIAGRDIANPI 311 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A I + AM+L +L DE+ +A + + AA++ +A G TPDM G ++ ADA+ Sbjct: 312 AMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDMGGTSSCSGFADAVV 371 Query: 357 KIILR 361 R Sbjct: 372 AATAR 376 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 350 bits (897), Expect = 7e-95, Method: Composition-based stats. Identities = 122/367 (33%), Positives = 185/367 (50%), Gaps = 30/367 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER----WGFALSFEQMEW-ASCEYYSHHGKMMPDD 61 I IP DGIGKEV+P ++V+ AA + S + + A E + GK +P + Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKSLPVE 93 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L + D FG+V P + ++ R+ D Y N+RP + Sbjct: 94 TVEALKNKCDGAIFGSVQSPSHKVEG--YSSPIVAMRKLVDLYANIRPCQDL-------- 143 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 ID +VRENTE Y V+ T + + + + T R RI A++LA Sbjct: 144 ---AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEIAYKLAV 200 Query: 180 SRPRK---TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 R + +T KSN L++S + E +++ YP+++ ++Q +D + + ++ P + Sbjct: 201 QRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKMILDPTQ 260 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 +DVVVA NL+GDILSD G A G +G+ SANL+ +L EPVHGSAPDI+GK I+N Sbjct: 261 YDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS---FALVEPVHGSAPDIFGKKISN 317 Query: 297 PIATIWAGAMMLDFLGNGDER---FQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVA 352 PIATI A AM+L L D + + + + A+ V+ TPD+ G T + Sbjct: 318 PIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGNTETLV 377 Query: 353 DAICKII 359 DAI K + Sbjct: 378 DAIIKNL 384 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 159/359 (44%), Gaps = 26/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG+E + + A + FE+++ E + + Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDVTGMEKNNKSSGDALHEAI 75 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P H S + R+E D Y +L ++ PG + Sbjct: 76 QSLKRNKVGLKGILFTPFEKGGHTSF---NVALRKELDIYASLVLIKNIPGFKT-----R 127 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++DF ++RENTEGEYS L + G VV + T RI ++AF+ A R Sbjct: 128 HDNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKIITEYKSKRIAQFAFDFALQNGR 183 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K++T K+N + ++ + +A Y I +D + V +P++FDV+V Sbjct: 184 KSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G ILS++G A G G+ P AN + +LFEP I G+ ANP A I Sbjct: 244 NLYGSILSNIGSALVGGPGVIPGANFGRDY---ALFEPGCRHVGLSITGRGEANPTAAIL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + +ML LG + + I AA VI G T D+ G+A+T AI + + Sbjct: 301 SACLMLRHLG-----LKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 111/372 (29%), Positives = 176/372 (47%), Gaps = 19/372 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T ++ +PGDGIG EV+ E R++ + + E Y + D Sbjct: 1 MATHKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGGAAY-DADKVAITDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 DA+ FGAVG P P LL+ R++ + NLRP +P + Sbjct: 60 TMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + + G + I V+ ++RI R AF+ Sbjct: 120 SLKPEVVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R R +TS K N + + + + + A Y +++ + Q D V P++ Sbjct: 180 LARKR-RNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +++EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATT 348 +ANP+A + + M L + + + + AI V+A G +T D+K +T Sbjct: 299 GLANPVAMLASFGMALRY----SLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVST 354 Query: 349 PQVADAICKIIL 360 Q+ +AI + + Sbjct: 355 SQMGEAIVQEMQ 366 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 108/370 (29%), Positives = 171/370 (46%), Gaps = 18/370 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +I +PGDGIG EV+ E +V+ ++ + A Y HG + D+ Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDE-DLAGGCSYDKHGTPITDEV 63 Query: 63 HEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 + + + GAVG P +LLK R+E + NLRP F + Sbjct: 64 FYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDAST 123 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + I +T + R+ + AF+L Sbjct: 124 LKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFDL 183 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R +TS KSN + + +E E + Y ++ D + + P++F Sbjct: 184 ARKRS-NRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQF 242 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKNI 294 DV+V NLFGD+LSD TG++G+ PSA+L + +++EP+HGSAPDI GK I Sbjct: 243 DVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEI 302 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQ 350 ANPIA+I + AM L + + + A+++V+ G +T D+ K +T Sbjct: 303 ANPIASILSFAMALRY----SLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSA 358 Query: 351 VADAICKIIL 360 + DAI + Sbjct: 359 MGDAIISKLQ 368 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 116/381 (30%), Positives = 174/381 (45%), Gaps = 30/381 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M T +I +PGD IG E++ E I+VL + HG + Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQ 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPV-RLFPGV--PC 117 + DA+ FG++G P+ H + LL+ R+ D + NLRP L P + Sbjct: 61 SVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGAS 120 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 P+ F VVREN G Y +V V+TR ++R+ R + + Sbjct: 121 PIREHVVKGTRFIVVRENCGGAYFGEKKEE-----EDVASDLWVYTRPEIERLARVSAAV 175 Query: 178 AQSRPRK-------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ R T+ SA K+N LA + + A+ +P+I Q D + Sbjct: 176 ARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSMAMLM 235 Query: 231 VMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGS 285 V P RF+ V+ N FGDILSD+ A TGT+G+ PSA+L ++EPVHGS Sbjct: 236 VRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGS 295 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG------PKT 339 APDI GK +ANP+A I + AMML + ++ + A+ +V+ +T Sbjct: 296 APDISGKGLANPVAQILSVAMMLRY----SMGLEKEATAVERAVVKVLDAKSEGGLEIRT 351 Query: 340 PDMKGNATTPQVADAICKIIL 360 D+ G AT QV DA+C+++ Sbjct: 352 GDLGGRATCSQVGDAVCEVLG 372 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 104/366 (28%), Positives = 169/366 (46%), Gaps = 32/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +A GDG+G E++ + +L+ A +S E ++ +Y + Sbjct: 6 MSVPITVAY--GDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAP 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E +SR + P + R+ YVN+RP + P+ Sbjct: 60 SAWESISRTRLLLKAPTMTPQ----GSGHKSLNVALRQRLGLYVNVRPCVSY----FPVV 111 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + D+D ++REN E YS + +++E T V + TR ++I YAF A++ Sbjct: 112 GTKHPDLDVVIIRENEEDTYSGVEHKLSEDTHECV----KISTRSASEKICAYAFNYARA 167 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T K N + ++ + +A+ YP+I + +D+ A+ PE FDVV Sbjct: 168 HNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVV 227 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NL+GDI+SD+ +G+IG+ SAN+ ++FE VHGSAPDI GKN+ANP Sbjct: 228 VTTNLYGDIVSDIVSLSSGSIGLTGSANIGDYY---AMFEAVHGSAPDIAGKNVANPSGL 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK------GNATTPQVADA 354 + A ML +G D+ I A + + G T D+ A+T + A A Sbjct: 285 LNAAVQMLVHIGQLDK-----AGVIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQA 339 Query: 355 ICKIIL 360 I + Sbjct: 340 IVGNLG 345 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 126/350 (36%), Positives = 171/350 (48%), Gaps = 15/350 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + R+ +PGDGIG EV+ RV AAA R+G L +E+ G + Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRI-GAAAIREEGAPVSK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + + DA+ GAVG P+ + LL RRE + NLRPV P + P Sbjct: 60 ETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D +VRE T G Y E SV+TR V+R+ R AFE A Sbjct: 120 LRPGVAEGVDLLIVRELTGGAYFGEK-----EEGEERASDLSVYTRGEVERVARVAFEAA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R + S K+N LA S W V +A +YP++ + +D V P RFD Sbjct: 175 RGR-RGRVASVDKANVLATSR-LWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRFD 232 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ NLFGDILSD G++G+ PSA+L + P +FEPVHGSAPDI GK +ANP Sbjct: 233 VILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGS-PGIFEPVHGSAPDIAGKGVANPY 291 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 A I + AMM +A I +E +A G TPD+ G++ T Sbjct: 292 AAILSAAMMFRH----GLGRPEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 138/367 (37%), Positives = 190/367 (51%), Gaps = 19/367 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA +PGDGIG EV +RVL A F + F + A E + G P+ Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALG-TSFPIEFRDYD-AGAECFRRTGTAFPEATQV 70 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGS--LLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A+ GA G PD + + G +K R D Y N+RP+RL G P L GK Sbjct: 71 ACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ--- 179 P DI F +VRENTEG Y++ GG ++ V TR GV+RI+RYA ELA+ Sbjct: 131 GPDDIRFTIVRENTEGLYAARGG--GNIIRGQIATDTLVMTREGVERIVRYAAELARDGQ 188 Query: 180 ---SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 + + +T K+N L S ++ E + + + P I + +D + + +PE Sbjct: 189 GAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERPEH 247 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V NLFGDILSDLG A G +G+APS + + + F+ HGSAP I GK +AN Sbjct: 248 FDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRDHGY---FQGSHGSAPTIAGKGLAN 304 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 PIA I +GAMMLD+LG + D +A I A V+ G TPD+ G+ +T A Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCAA 364 Query: 354 AICKIIL 360 IC + Sbjct: 365 EICATLG 371 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 148/362 (40%), Positives = 203/362 (56%), Gaps = 14/362 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M +T+ +A +PGDGIG EV+ E +RVL+ A +L Q + ++ G+++ D Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVP-ADVSLDTTQYPF-GAGHFLETGQILTD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVP---DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 L++ DAI GAVG I G LLK R FD Y+NLRP L PGV Sbjct: 59 SDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVAS 118 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PLA PG +DF VVRE TEG Y+ GG + GTEHE+ + SV T GV+R +R+AFEL Sbjct: 119 PLAA--PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAFEL 176 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R RK +T K+N L + W V+ +A +P++ D H+D V P RF Sbjct: 177 AEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPSRF 236 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V+ NLFGDI++DL A +G IG+A S N+NP FPS+FEPVHGSAPDI G+ A+P Sbjct: 237 DVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADP 296 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 A I + A++LD LG + + + T D +T +V DAI + Sbjct: 297 TAAILSVALLLDHLGLSEAAARVSAAVSDDLAARA------TGD-AAPRSTAEVGDAILR 349 Query: 358 II 359 + Sbjct: 350 AL 351 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 343 bits (880), Expect = 6e-93, Method: Composition-based stats. Identities = 97/359 (27%), Positives = 160/359 (44%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +A + GDG+G E+L V Q G + FE++ D Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEV-----AVNQESEDATFTDAL 118 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + R + Y ++ R FPGV + Sbjct: 119 LAMKRNGVGIKGNFAT------EPGQSSRNVALRLNLNLYAFVQRCRNFPGVVT-----R 167 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS L G VV + TR RI ++AF+ A R Sbjct: 168 HQNVDIVIIRENTEGEYSRLEHENVPG----VVESLKIITREKSTRIAQFAFDYAVRHNR 223 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + ++A+NYP+I ++ ID C + V +P++FDV+V Sbjct: 224 KKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFDVIVLP 283 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ NL P+ +LFE S + GKNIANP + Sbjct: 284 NLYGNIVGNVAAGLVGGAGLTTGINLGPQ---NALFEMGTRNSGRSLAGKNIANPCGMLL 340 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A ML++LG+ + I ++ +VI +T D+ G+ T +V +A+ K + Sbjct: 341 TSADMLEYLGHI-----KEAKLIRDSVVDVIGEQKIRTADLGGSFKTSKVIEAVLKSLR 394 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 343 bits (879), Expect = 7e-93, Method: Composition-based stats. Identities = 108/370 (29%), Positives = 172/370 (46%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG E + E +++ E ++ C Y HG + + Sbjct: 1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAY-DAHGAAISEA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC-- 117 ++ DA+ FGAVG P P + LL+ R++ + NLRP +P + Sbjct: 60 DMQKALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 +A++R + S K N + + + E Y +++ + D + V QP++ Sbjct: 180 MARTRQ-NRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + + AI V+ G +T D+ T Sbjct: 299 GIANPIAMIASFAMCLRY----SFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGT 354 Query: 349 PQVADAICKI 358 ++ +AI Sbjct: 355 VEMGEAILAE 364 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 103/359 (28%), Positives = 166/359 (46%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+ VL + G + FE ++ + D Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVLH----KCGAPIDFEVIDI--------KDESSTDAAI 134 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 L R G + + P + RR+ D Y N+ P + PGV + Sbjct: 135 ISLKRNGIGLKGTITTNISNPQS---QSINAQIRRKLDLYSNIVPCKSIPGV-----WTR 186 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G +D V+RENTEGEY SL +G VV + T + RI ++AF+ A R Sbjct: 187 HGQVDLVVIRENTEGEYGSLEHENVDG----VVESLKIITEKKSRRIAKFAFDYALQNNR 242 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 + +T+ K+N + ++ + E ++++Y +I ++ ID C + V P++FDV+V Sbjct: 243 RKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFDVMVMP 302 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+S +G G IG+ P N+ + ++FE D+ G N ANP ++ Sbjct: 303 NLYGNIVSHIGIGLVGGIGLVPGKNIGDKY---AIFESGARNIGSDLVGLNRANPCGFLF 359 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A+ML LG + I +A+ I +G +TPD++G+ TT DA+ K I Sbjct: 360 TSALMLRHLG-----LDDYADIIESAVRTTIKNGKCRTPDIQGDRTTADFIDAVIKEID 413 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 109/372 (29%), Positives = 177/372 (47%), Gaps = 18/372 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ +PGDGIG EV+ + R++ + + Y HG P + Sbjct: 1 MAAKKLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGGAAY-DVHGTPYPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E DA+ GAVG P P LL R++ + NLRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y ++ V+T + RI R AF+ Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R K L S K+N L ++ + +E ++ E +P++ ++D + V P++ Sbjct: 180 LARKRN-KKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V N+FGDILSD TG++G+ PSA+L + +L+EPVHGSAPDI GK+ Sbjct: 239 FDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKD 298 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 +ANP+ATI + AM L + + I A++ V+ G +T D+ K +T Sbjct: 299 MANPLATIMSFAMCLRY----SFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTT 354 Query: 350 QVADAICKIILR 361 + +A+ + + + Sbjct: 355 VMGEAVVRELDK 366 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 117/371 (31%), Positives = 167/371 (45%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E I+VL+A A F Q H + D Sbjct: 1 MATHNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-SLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 + DA+ GA+G P+ LLK R+E Y NLRP Sbjct: 61 EALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + DF VVRE T G Y E ++R + RI R A Sbjct: 121 SPLKAEVCRGTDFIVVRELTGGIYFG---DRTEDDGSGYACDTEPYSRAEIVRIARLAGF 177 Query: 177 LAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA P + S K+N LA S + + +++ +P+++ + Q ID V P Sbjct: 178 LALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN----PERTFPSLFEPVHGSAPDIY 290 + VV+ SNLFGDI+SD G+IG+ PSA+L + ++EP+HGSAPDI Sbjct: 238 ALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDIS 297 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP+ TI + AMML + + + + AA++ I +G KT D+ GNATT Sbjct: 298 GKGIVNPVGTILSVAMMLRY----SLNLPKEADAVEAAVKAAIDNGTKTKDLGGNATTSD 353 Query: 351 VADAICKIILR 361 + +A+ + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 121/364 (33%), Positives = 182/364 (50%), Gaps = 27/364 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + ++ +PGDGIG EV+ + +L+A AE G +++ Y H + P+D Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHI--------SLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + D I GAVGWP + +++ R + D Y N+RPV+L PGV Sbjct: 69 ARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGV 128 Query: 116 PCPLAG-----KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRI 170 ++G +P +D ++RENTEG Y+ +GG++ G V + TRRG +RI Sbjct: 129 AHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCERI 188 Query: 171 LRYAFELAQSRPR-------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHI 223 +R AFEL + R R K +T K N L + E +A YP+I + + Sbjct: 189 IRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVASEYPDIANELAIV 247 Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D V QPE +DV V +NLFGDI++DL G +G+A N+ E ++FEP+H Sbjct: 248 DAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEH---AMFEPIH 304 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTP 340 GSAP + GK+ ANP+A + A L +LG D R + + + A+ V G P T Sbjct: 305 GSAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTV 364 Query: 341 DMKG 344 D+ G Sbjct: 365 DLVG 368 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 340 bits (872), Expect = 6e-92, Method: Composition-based stats. Identities = 120/346 (34%), Positives = 177/346 (51%), Gaps = 9/346 (2%) Query: 17 KEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL-SRFDAIYFG 75 V+ E +L+ ER G + +++ + Y G P+ + A+ G Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDL-GADRYLRDGTTFPNQIQIAIQRECSAVLLG 77 Query: 76 AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVREN 135 A+G P VP+ L R +D Y N+RPVR PL G+ DIDF V REN Sbjct: 78 ALGDPR-VPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFREN 136 Query: 136 TEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 TEG Y +GG+ GT EV I E V TR+GV+RI+R AF+ A++ R +T A KSN + Sbjct: 137 TEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMADKSNAM 196 Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 + W + YPEI+ + ++D LC + P +F V+V +NLFGDI++DLG Sbjct: 197 RHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGA 256 Query: 256 ACTGTIGIAPSANLNP-ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNG 314 A G +G+A SAN++ + +LFEPVHGSAP + GK+IANP A + ++L LG Sbjct: 257 ALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLG-- 314 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + I + + + G T D+ G T + + I Sbjct: 315 ---WPEEERRIERWVSQALDQGMCTVDVGGTLGTRAAGAWVREQIA 357 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 159/359 (44%), Gaps = 32/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDG+GKE+ + +A + +E + ++ + Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINIKQTDHKEGV-----YEAV 78 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E L R G P D + R++ D Y N+ + GV + Sbjct: 79 ESLKRNKIGLKGLWHTPA---DQTGHGSLNVALRKQLDIYANVALFKSLKGVKT-----R 130 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID V+RENTEGE+S L G VV V TR +RI R+AF+ A+ R Sbjct: 131 IPDIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRPKTERIARFAFDFAKKYNR 186 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K++T+ K+N + + + + + + YP+I +D + V +P +FDV+V Sbjct: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +++G IL ++G A G G+ AN + ++FEP DI G+N+ANP A I Sbjct: 247 PSMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEPGSRHVGLDIKGQNVANPTAMI 303 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + +ML+ LG + I A+ E IA G T D+ G+++T + I + Sbjct: 304 LSSTLMLNHLG-----LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 338 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 175/366 (47%), Gaps = 16/366 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA +PGDGIG E++ + VL+ ER G +Y G D+ Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAFSDENM 65 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + DA+ GA+G P + + L R E D Y LRP+R +P +P L K+ Sbjct: 66 AACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDKR 125 Query: 124 PGDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID +VRE TEG YS G + + V + + +R G R+ +AF +A+ R Sbjct: 126 ASQIDLVLVREQTEGILYSRCRGTI---EDDRVAWETMMISRNGTSRVSEFAFRVAERRA 182 Query: 183 RK-----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + + +SN L SM ++ +AE +P + D ++D + V P F Sbjct: 183 KSRRRPGKVLCVDRSNAL-TSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKSPWEF 241 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V N FG ILSDL G++G+APSA++ + ++F+P HGSAP I G+ +ANP Sbjct: 242 DVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEKH---AVFQPAHGSAPHIAGQGLANP 298 Query: 298 IATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 +A I + A+MLD+L +G+ R + A+E+ + + G T + AI Sbjct: 299 VAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALTV-VCPVEFGGKDGTAAITKAI 357 Query: 356 CKIILR 361 I + Sbjct: 358 IAQIRK 363 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 177/366 (48%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IA + GDGIG E+ +G+ V+ A E++G +++E + G P++ + Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYA-ICGADAIDKVGDPFPEETYR 61 Query: 65 QLSRFDAIYFGAVGWPDTVPD---HISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPL 119 DA+ F AVG P D + LL R++ + N+RPV+ F + PL Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + DF +RE T G Y + +++ +++TR ++RIL+ FE A Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQ-----DNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RK LT K+N LA S W + + MA YPE+ D +D + + +P+ FDV Sbjct: 177 KR-RKHLTVVDKANVLASSR-LWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDV 234 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N FGDIL+D G +G++G+ PSA+ +FEP+HGS P G NIANP+A Sbjct: 235 MVTENTFGDILTDEGSVISGSMGLLPSASTGES---TPVFEPIHGSWPQAKGLNIANPLA 291 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADAI 355 I + AM+ ++ + I A++ + +TP++ T +V I Sbjct: 292 QILSVAMLFEYF-----DCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWI 346 Query: 356 CKIILR 361 I + Sbjct: 347 VDYIRK 352 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 95/360 (26%), Positives = 160/360 (44%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PG GIG E++ R ++A + FE + + M D Sbjct: 47 RFFVTLLPGHGIGPEMM----RHVEAIFACGKVPVDFETIIV---DANVGDASSM-DHAI 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + + R G + +++ L R + + YVN+ R PG+ + Sbjct: 99 KSIRRNGVALKGNIETTSY---SMTVEPRNLLLRNKLELYVNVVHCRNHPGI-----NTK 150 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D V+R+NTEGEYS L V G VV + T +I +Y FE A++ R Sbjct: 151 HKGVDIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYCFEYARTHMR 206 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T K+N + ++ + + +A+ YP+I + ID C + V P +FDV++ Sbjct: 207 KKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDVMLVP 266 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ N E ++FE + + GKN+ANP+AT++ Sbjct: 267 NLYGNIVVNVACGLVGGAGVTSGRNYGKEY---AVFETATRNTGTPLVGKNLANPVATLY 323 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIILR 361 A ML L I AIE+ + T D+ G+ATT +V + I K + + Sbjct: 324 AAVDMLKHL-----ELWDHAVVIRRAIEKTVNRDKVHTKDLGGDATTSKVVENILKEVQK 378 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 336 bits (862), Expect = 7e-91, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 175/374 (46%), Gaps = 20/374 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +I + GDGIG EV+ + RV+ + A E Y G + D Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGGAAY-DAQGTPLHD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 D DA+ GAVG P P + LL+ R++ + + NLRP +F + Sbjct: 60 DTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAE 119 Query: 117 -CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYA 174 L + +D +VRE T G Y ++ + V+ + R+ + A Sbjct: 120 ASTLKTELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKVA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LA R K L S K+N + S W E V + +YPEI + D + V QP Sbjct: 180 FDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 ++FDV+V NLFGDILSD TG++G+ PSA+L +++EPVHGSAPDI G Sbjct: 238 KQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM---KGNA-T 347 ++ ANP+ATI + +MML + + + + A+ V+A G +T D+ Sbjct: 298 QDKANPLATILSFSMMLRY----SFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVG 353 Query: 348 TPQVADAICKIILR 361 T + DA+ + + Sbjct: 354 TTGMGDALLAEMAQ 367 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 336 bits (862), Expect = 7e-91, Method: Composition-based stats. Identities = 95/360 (26%), Positives = 160/360 (44%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PGDGIG E+L ++ A + FE+ + S D+ Sbjct: 44 RHTVTLLPGDGIGPEMLDIVQKIFTFA----NVPVDFEECQLDSKPTSPESDL---DNAI 96 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + D ++ RR D + N+ P +P + Sbjct: 97 MSIQRNGVAIKGNIET---KYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPT-----R 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 I+ ++RENTEGEYS G VV + TR ++RI R+AF+ A + R Sbjct: 149 HKGINIVMIRENTEGEYSGHEHETVNG----VVESLKICTREKLERISRFAFDYAIAHNR 204 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K +T+ K+N ++ + + V +A + YP I +D +D + V +P++FD+++ Sbjct: 205 KKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQFDIMLM 264 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATI 301 NL+G+I+S++ G G+ N+ + ++FE + I G++IANP A I Sbjct: 265 PNLYGNIISNIACGLVGGPGLVSGMNIGDKY---AVFETGTRNTGSGIAGQDIANPTAFI 321 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 AG ML +LG + N I A+ + I T D+ G A T V +A+ + I Sbjct: 322 RAGVDMLHYLG-----LTEYANLISDALFDAIVIKRLHTKDIGGTAKTSDVVNAVMRNIE 376 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 111/356 (31%), Positives = 168/356 (47%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRIA I GDG+G E++ + +L+ + A Y+ GK + D+ E Sbjct: 1 MRIAVIKGDGVGPEIMGATLSLLERYIGADFIEIK------AGKSYFIEEGKPIEDNAIE 54 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D++ G V P P S RREF Y N+RP R + G+ Sbjct: 55 KIRECDSLLKGPVATPTKGP---SYPSVNTLLRREFKLYANVRPFRSYEGIS-------I 104 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID +VREN E Y + + I V T+RG +RI +AF LA+ R Sbjct: 105 RRIDTILVRENLECLYYGWEVE-----DEDRAIAMRVITKRGAERISEFAFNLAKREGRG 159 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K N L + + + +A + ++R D + +D + V FDV++ N Sbjct: 160 RVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVMLTPN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSD+ G+IG+ SA + + + FEP+HG+ DI GK +ANPI I A Sbjct: 219 LYGDILSDVAAGVVGSIGLCGSAQIGED---FAAFEPIHGTGEDIAGKGVANPIGMIIAA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +MMLD+L R + I A++ VI TPD+ G+ T QV + I + Sbjct: 276 SMMLDWLWERG-RSPKRGEKIREAVDSVIRDRILTPDLGGDFRTEQVVEKIVDRLR 330 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 119/361 (32%), Positives = 174/361 (48%), Gaps = 17/361 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I + GD IG E++PE +RV+QAAA R G A+ ++ + G +PD E Sbjct: 1 MKIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPI-GRAALDSLGSTLPDGTIE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L D G +G P R+ FD + N+RPV+ +PC Sbjct: 60 RLDALDGWLLGPIGH-MAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL-----H 113 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D +VREN EG G +V I V TR G ++ R AFELA++R Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFELARAR 173 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ LT+ K + + E +A YP++ +D+ +D R VM P+R+DVVV Sbjct: 174 -RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYDVVV 232 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDIL+D G +G+A P ++ + HGSAPDI G+ IANP A I Sbjct: 233 TTNMFGDILTDEAAGLVGGLGMAAGLCAGPRH---AMAQATHGSAPDIAGRGIANPYAMI 289 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKI 358 +G M+LD+LG A I A+ +I TPD+ G TT + AI + Sbjct: 290 MSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQGTTAGMGSAIIEA 349 Query: 359 I 359 + Sbjct: 350 M 350 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 108/382 (28%), Positives = 167/382 (43%), Gaps = 27/382 (7%) Query: 1 MMKT-MRIAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMM 58 M K +I +PGDGIG EV+ E RVL+ A + E ++ C HG+ + Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCS-IDKHGEPL 59 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVP-DHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 E DAI GA+G P + +LL R+ Y N+RP Sbjct: 60 TAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLL 119 Query: 117 --CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL +D V+RE G Y + + + +++ V RI R Sbjct: 120 AYSPLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSR 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 ++A P + S K+N LA S + E + +P+++ D +D V P Sbjct: 180 RQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANP 239 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP----------SLFEPVH 283 ++ + V++ NLFGDILSD G++G+ PSA+L +P ++EP+H Sbjct: 240 KKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIH 299 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV-----IAHGPK 338 GSAPDI G+ IANPI TI + AM L ++ I AA+E G + Sbjct: 300 GSAPDIAGQGIANPIGTILSAAM----LCGTRSVWRSPAKAIEAAVEGARRQGDRREGLR 355 Query: 339 TPDMKGNATTPQVADAICKIIL 360 T D+ G++ T + + +I+ Sbjct: 356 TADLGGSSKTKDIGHKVVEILK 377 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 108/381 (28%), Positives = 163/381 (42%), Gaps = 36/381 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+T + +PGDG G E++ VL AA GF + ++ + A + ++PD Sbjct: 1 MRTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWD-VHQAGQRALAESESLLPDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + A G P + R+E D Y LRPVR P + Sbjct: 60 TLNSIRTNGAALKGPTTTPI----GTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEE 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLG---------------GRVNEGTEHEVVIQESVFTRRG 166 + +D VVRENTE Y+ L G + + + FT G Sbjct: 115 PERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPFTPHG 174 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +R++ +AF A RK + S + + + +A +P I + L Sbjct: 175 CERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVPVPAL 234 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 CA V P R DV+V NL+GDI+SD+ A G++G+AP AN+ ++FE HGSA Sbjct: 235 CADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAHH---AVFEATHGSA 291 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDM--- 342 P+ G NP A I++G M+LD LG + I AA+E+V+A G T D+ Sbjct: 292 PEFAGSGRLNPTALIFSGCMLLDHLGEHET-----AARIRAAVEDVVAAGEVLTFDLLAP 346 Query: 343 ---KGNATTPQVADAICKIIL 360 ATT + A+ + Sbjct: 347 QRSADAATTVEFTRAVTDRLG 367 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 117/356 (32%), Positives = 173/356 (48%), Gaps = 31/356 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA IPGDG+G E++ I VL+ ++ L E A E G +P++ Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFE-AGDETKRKRGVALPEETLN 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA A+G S +L R++ D YVNLRP + +P + Sbjct: 61 GVMNSDATLMVAIG--------ESAREVILPLRQKLDLYVNLRPAKSYP------VPRAI 106 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VRENTE Y G R + + + TRR +RI R+ + A+ R + Sbjct: 107 PGFDLTIVRENTEDLYVMSGWR-----GLDTAVDLRIITRRASERICRFGYRYARERGKS 161 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 + K+N L M + E +AE + + ++D R M FDV++ +N Sbjct: 162 RVYVVHKANVLGGCM-LFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVIITTN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDILSDL A G +G+ PSAN+ R ++FEPVHG+AP+I GKNIANP+ATI + Sbjct: 219 MFGDILSDLAAAFIGGLGMYPSANIGESR---AIFEPVHGTAPEIAGKNIANPMATILSA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMM+ +LG+ I A+ G TPD+ G+ T +V I +I+ Sbjct: 276 AMMMGWLGHEGG-----SKLIEEAVRRACELGYTTPDVGGSMRTKEVGLKISEIMR 326 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 97/357 (27%), Positives = 159/357 (44%), Gaps = 36/357 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPG GIG E+ V +A + F+ ++ + E DD Q Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL----HVPIKFDVLDNFNFEN---------DDSKSQ 80 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L + + I G + + KF + D Y N+ G+ ++ Sbjct: 81 LRKNECILLGVMTEKNQKYTD------NYKFYKYLDLYSNITFAFSVEGIT-----QRHN 129 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 + D V+RENTEGEYS + V G VV V T++ RI YAFE A R+ Sbjct: 130 NTDIVVIRENTEGEYSGVEHEVYPG----VVESIKVTTKQASLRIAEYAFEFAHLSGRRK 185 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A+ Y I++++ ID C + V P +FDV+V NL Sbjct: 186 VTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVMVMPNL 245 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +G I+ ++ TG +G+A A++ + S + + DI GKN+ NP A + + Sbjct: 246 YGSIVQNVVAGITGGVGMAAGASIGKDHALFS--QGCRHTGRDIAGKNVVNPSAMLVSST 303 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 ++L LG + I A++ I KT D+ GNATT Q + + + R Sbjct: 304 LLLRHLG-----LPNFADQICRAVQHTIQDKKIKTKDIGGNATTDQFTSEVIRSLGR 355 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 126/356 (35%), Positives = 173/356 (48%), Gaps = 15/356 (4%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA IPGDGIG EV+ + VL A G + ++ + + Y G+ + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDAL----GLGTRTDILDHVNADTYLRTGEALTGSDLDR 76 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + +A GAVG P + D + G L R E D YVN RP RL+ PL Sbjct: 77 IRSSEAALLGAVGDPR-LGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARR 135 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ID +VRENTEG YS +GG GT E+ + + TR GV R+L +AF A R++ Sbjct: 136 AIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA----RRS 191 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N + W +P I ++D R P FDV+V +N Sbjct: 192 VCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNS 251 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL A G +G+A SANLNP T +LFEPVHGSAPDI G ANP I + A Sbjct: 252 YGDILSDLTAALAGGLGVAASANLNP-VTGRALFEPVHGSAPDIAGSGTANPFGAILSVA 310 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 ++ + LG +E +A G TPD+ G T +V A+ + R Sbjct: 311 LLAEHLGRNEEADAVRRAV-----AAAVAAGRVTPDLGGPLGTKEVGAAVLAELRR 361 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 329 bits (845), Expect = 6e-89, Method: Composition-based stats. Identities = 130/384 (33%), Positives = 190/384 (49%), Gaps = 42/384 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ RI IPGDGIG EV + ++V++AA +GF+L + E+Y +++PD Sbjct: 1 MKSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPY-GAEHYLSTRQVLPDH 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E++ DA+ GA+G P P I G LLK R FDQY N+RPVR F P PL Sbjct: 60 ALEEMEGLDALLLGAIGDPRVQP-GILERGILLKLRFHFDQYANIRPVRSF--TPGPL-- 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG----------RVNEGT-------------EHEVVIQ 158 G ++ V+RENTE Y +G V G +Q Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T G R +YAF+LA + +T ATKSN + ++ +A Y + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++D LC + V P F V++ N+FGDI+SDL G +G+APS N+ S+ Sbjct: 232 RVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDR---LSM 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 FEPVHGSAPDI G++ ANP+A+I +GAM+L LG A + A++ ++ Sbjct: 289 FEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETS-----AAKAMEDAVQRYLSGPVE 343 Query: 338 -KTPDMKGNATTPQVADAICKIIL 360 +M G T DA+ + + Sbjct: 344 ELPIEMGGRLGTRGAGDAVVRRLE 367 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 329 bits (844), Expect = 8e-89, Method: Composition-based stats. Identities = 108/411 (26%), Positives = 168/411 (40%), Gaps = 66/411 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM--MP 59 I I GDGIGK+V P +VL+AAAE G +S+ ++ +A +G+ +P Sbjct: 28 PDNPIIPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRV-YAGESAREEYGEDVNLP 86 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D+ + + G + P + R+ D Y N+RP GVP P+ Sbjct: 87 DETVDAIREHRVAIKGPLTTP----VGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPM 142 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 P ++D RENTE Y+ + +V I Sbjct: 143 KA--PEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLK 200 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE---- 215 T +G R++R A + A R +T K N + + + + +A E YP+ Sbjct: 201 PITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVF 260 Query: 216 -------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + +++ D + ++ + FD++ NL GD LSD A Sbjct: 261 AAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLSDAAGA 320 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G +GIAP N L EPVHGSAP G+++ANP A I +G +M D+LG Sbjct: 321 QIGGLGIAPGGNFG---KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDYLG---- 373 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + A + I A+EE I+ G T D++ T + D I I + Sbjct: 374 -WDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 329 bits (844), Expect = 9e-89, Method: Composition-based stats. Identities = 108/362 (29%), Positives = 174/362 (48%), Gaps = 13/362 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI +P DGIG E++ + VL++A + L+F+ + +G + D+ Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDV-GFTSLEKYGTTLRDEVLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + +D + G D FR D Y N+RP R P + + + Sbjct: 60 KAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRT 119 Query: 125 GDIDFYVVRENTEGEYSSL---GGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D ++RE TEG Y G ++ I TR +RI R AFELA R Sbjct: 120 --MDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR 177 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 +K +T+ K+N ++ + E V +A ++PE+R D ID A V PERFDV+V Sbjct: 178 -KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 A+N +GDI+SDL +G++G+A S + + HGSAPDI G++ ANP++ I Sbjct: 237 ATNFYGDIISDLASELSGSLGLAGSMMASDTH---CCAQAQHGSAPDIAGQDKANPVSMI 293 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + AM++ ++G + A + AA++ V+ + +TPD+ GN + K+ Sbjct: 294 LSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKV 353 Query: 359 IL 360 I Sbjct: 354 IQ 355 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 106/369 (28%), Positives = 165/369 (44%), Gaps = 34/369 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG+E++ ++A G + +EQM+ E + G + D Sbjct: 32 QAHTVLTFDGDGIGREIVSAAKECIEA----TGVNIRWEQMDM-GYEAMQNTGVYIDDSH 86 Query: 63 HEQLSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 + ++ G + P FR+ F + N+RPVR PGV Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P D+D V+RENTE Y+ V+ T H V +R +R+ ++F+ Sbjct: 147 AP-----FNDVDLVVIRENTEDVYTGEETWVDADTVHCV----KRISRGASERVADFSFK 197 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE--NYPEIRWDKQHIDILCARFVMQP 234 A+ RK +T+ K+N S + A + I D Q D + +++P Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLMIEP 257 Query: 235 ERFDVVVASNLFGDILSDLGP----ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 + FDV+ NL+GD+++ L G++G+ PS N+ T +LFEP HGSAPDI Sbjct: 258 KSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG---THQALFEPAHGSAPDIA 314 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK IANP + I +G MML LG +A + A+ + A G D G A T + Sbjct: 315 GKGIANPTSQILSGCMMLSHLGEF-----EASQRLENALRAMYASGIVPVDFGGQADTKE 369 Query: 351 VADAICKII 359 V A+ K + Sbjct: 370 VVAAVLKHL 378 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 328 bits (842), Expect = 1e-88, Method: Composition-based stats. Identities = 93/359 (25%), Positives = 161/359 (44%), Gaps = 29/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ IP DGIG+ ++ + V Q G + FE+ +D Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKS--FNDIK 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G I + R + D Y N+ + +P V + Sbjct: 99 TSVLRNGTALKGNWATSM----GIDSKSYNVLLRHDLDLYANVVKFKSYPTVIT-----R 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D V+RENTEGEY++L G V+ + T++ +RI +YAF+ A R Sbjct: 150 HNNVDLIVIRENTEGEYTNLEHENIPG----VIEMIKIITKKKSERIAKYAFDYAMENNR 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + + + +AE YPEI ++ ID + V +PE+FDV+V Sbjct: 206 KKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFDVIVTP 265 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G++LS++ A G G+ N +FE S DI KNIANP++ ++ Sbjct: 266 NLYGNVLSNIAAALVGGPGLPHGENHG---NGIHVFESGTRNSGMDIATKNIANPMSMLF 322 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A +L L + + I + I +++ +T D+ GN +T + + + K + Sbjct: 323 AATALLRHL-----QLSKHAQLIESCIHKIVTTNQARTVDIGGNTSTSEFFEILVKEVE 376 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 153/353 (43%), Positives = 203/353 (57%), Gaps = 17/353 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A IPGDGIG EV+ EG++VL+A A + + + G+++PD + Sbjct: 1 MRLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDL-GASRWQRTGELLPDTVLD 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L R DAI GA+G P VP I G LL+ R E D +VNLRP RLF GV PLA P Sbjct: 56 ELRRHDAILLGAIGDPS-VPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAA--P 112 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 G ID VRE TEG Y GG + T HEV + S+ T GV+R++RYAFE A +RPR+ Sbjct: 113 GAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALARPRR 172 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT K+N L + W VE ++ +PE+ QH+D FV P RFDV+V N Sbjct: 173 HLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVIVTDN 232 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDI++DL A TG IG+A S NL+ T PS+FEPVHGSAPDI GK +A+P AT+ + Sbjct: 233 LFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSV 292 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 ++LD LG D+ + AA+ ++ T D + T V D + Sbjct: 293 GLLLDHLGRADQ-----ARKVNAAVAFDLS----TRDPEAQVRTEDVGDRLAA 336 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 112/360 (31%), Positives = 173/360 (48%), Gaps = 15/360 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I +PGDGIG E++ +RVL+AA++R+ L + A HG + E Sbjct: 1 MKIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIG-HDIAGHASLQRHGATVTPALLE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D + G + D + FR+E D Y N+RP R FPG+ + Sbjct: 60 KVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAH-----RV 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G+ + VVRENTEG Y+ + VI TR +RI R AF+LA++R Sbjct: 115 GEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDLARTR 174 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R ++ K+N L I + + +A +P++R D +D + A V P+RFDV+V Sbjct: 175 AR-HVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFDVIV 233 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDILSDL +G++G+ S N + ++ + VHGSAPDI G+NIANP + I Sbjct: 234 TTNMFGDILSDLTAELSGSLGLGGSLNAGKDH---AMGQAVHGSAPDIAGRNIANPYSLI 290 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + +L + G F A I + T D G T + + + + Sbjct: 291 LSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRDAGGELGTAEAGQSFVRRL 350 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 165/366 (45%), Gaps = 31/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI + G+GIG E+ IRV++A G ++ + A E +G +P + Sbjct: 1 MRIGVLKGNGIGPEITAATIRVIEA----TGIQPEWDFIPIA-DEAVRLYGHALPPQVIQ 55 Query: 65 QLSRFDAIYF---------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 ++ G + T ++ RRE + +VN RP+R + G+ Sbjct: 56 RIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGI 115 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +D ++RE TE Y + +G TR ++ +YAF Sbjct: 116 SG-----RHEKMDMVIMREITEDTYIGWEKPLEDGA---AAEAIKRVTRSASWKVSQYAF 167 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+ RK ++ K+N L + + + +A YP+I D ID C V P Sbjct: 168 EYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPC 227 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDVVV N +GDI SDL G++G+AP AN+ S FE HG+APDI G A Sbjct: 228 WFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDSA---STFEAAHGAAPDIAGTGAA 284 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADA 354 NPIA I +GA +L G G + I A+ VI G TPD+ G +TT QVADA Sbjct: 285 NPIALILSGAELLAHAGYG-----KGSEAIREAVTRVIEAGRTLTPDLGGRSTTEQVADA 339 Query: 355 ICKIIL 360 I + Sbjct: 340 ISVEVR 345 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 326 bits (837), Expect = 5e-88, Method: Composition-based stats. Identities = 119/408 (29%), Positives = 179/408 (43%), Gaps = 62/408 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG +VLP+ IRVL+A GF ++ + E + + G +PD Sbjct: 1 MARPTVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADI-GWECWCNEGNALPDR 55 Query: 62 WHEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 + L + FGA+ P+ +S + ++ R+ F+ V +RP Sbjct: 56 TIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCL 115 Query: 111 LFPGVP------CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT------------- 151 FPG P G + +D V R+NTEG Y+ + Sbjct: 116 SFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAA 175 Query: 152 -----EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 E+ + + T++ RI AF+ A+ K +T K N L + +E Sbjct: 176 FANTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVA 235 Query: 207 EAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 + + + YPEI +ID PE + V+VASNLFGD++SD G +G A S Sbjct: 236 KQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAAS 295 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKN--IANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 N+ E ++FEP HGSAP N I NPIA I + AMMLD +G ++ + Sbjct: 296 GNIGDE---VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHIGESEK-----ADR 347 Query: 325 ILAAIEEVIAHGP-KTPDM-----------KGNATTPQVADAICKIIL 360 I AI +V+ G +T DM +G A T Q+ DAI + Sbjct: 348 IRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVE 395 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 109/409 (26%), Positives = 169/409 (41%), Gaps = 64/409 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + + I GDGIGK+V P +VL+AAA G +S+ ++ +A + + +PDD Sbjct: 30 PENPIVPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRV-FAGESAREKYDENLPDD 88 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + G + P + R+ D Y N+RP GVP P+ Sbjct: 89 TVNAIDEHRVAIKGPLTTP----VGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKA 144 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVF 162 P ++D RENTE Y+ + +V I Sbjct: 145 --PEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPI 202 Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE------ 215 T G R++R A + A R +T K N + + + E +A E YP+ Sbjct: 203 TEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVFAA 262 Query: 216 -----------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + + + D + ++ + F V+ NL GD LSD A Sbjct: 263 PDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSDAAGAQI 322 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +GIAP AN R L EPVHGSAP G+N+ANP A I +G +M D++G + Sbjct: 323 GGLGIAPGANFGDAR---VLAEPVHGSAPKRAGQNMANPTAMILSGRLMFDYMG-----W 374 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + A + + A+EE I+ G T D++ T + +DAI + I + Sbjct: 375 KDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 89/359 (24%), Positives = 162/359 (45%), Gaps = 27/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + +PGDG+G E++ V +AAA + F++ + + + K+ + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL--EQVL 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P ++ ++ RR+ D + N+ V+ PG + Sbjct: 102 SSMKENKVAIIGKIHTPMEYKGELA--SYDMRLRRKLDLFANVVHVKSLPGYMT-----R 154 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RE TEGEYSSL G V+ + TR RI ++AF+ A + R Sbjct: 155 HNNLDLVIIREQTEGEYSSLEHESARG----VIECLKIVTRAKSQRIAKFAFDYATKKGR 210 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T+ K+N + + + + E +AE YP+I+++ ID C + V P +FDV+V Sbjct: 211 GKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ +L G G+ P + + E ++FE G+NIANP A + Sbjct: 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEY---AVFETGARHPFAQAVGRNIANPTAMLL 327 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAA-IEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + ML L + + I A + + +T DM G +TT ++ + Sbjct: 328 SASNMLRHL-----NLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 381 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 103/385 (26%), Positives = 169/385 (43%), Gaps = 49/385 (12%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++IA +PGDGIG EV + V + + + E++ G +P Sbjct: 6 PIKIAVLPGDGIGIEVTEATLPVFEVL----DVPVILNYGDI-GWEFWKKEGAAIPSRTW 60 Query: 64 EQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVRLF 112 + ++ D + GA+ + +++ R+ D + N+RP Sbjct: 61 QLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSI 120 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT---------------EHEVVI 157 P +F ++REN+EG Y E Sbjct: 121 DDQSKP--------FNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASC 172 Query: 158 QESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 + ++ G+ R+ +AF+ A +T A K N L S + + E+ A+ YP+I+ Sbjct: 173 ALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQ 232 Query: 218 WDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPS 277 D ++D + + PE+F V+VA N+FGDILSD+G G +G+APSAN+ + ++ Sbjct: 233 ADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSY-- 290 Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG- 336 FEPVHGS P I KN ANP A +M+L+ G D I+ A+ +VI Sbjct: 291 -FEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPDR-----AKKIVNAVMQVIKEKR 343 Query: 337 PKTPDMKGNATTPQVADAICKIILR 361 T D+ G+ATT +A+A+ + R Sbjct: 344 FITYDLGGHATTTDMANAVIEHCAR 368 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 107/419 (25%), Positives = 167/419 (39%), Gaps = 72/419 (17%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG ++ RV+ AA E+ G + A + + G+ +P Sbjct: 16 PNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + + + + G + P + + R+E D + LRPVR F GVP P+ Sbjct: 76 QETLDTIKEYLIAVKGPLTTPI----GGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 +P D+D + RENTE Y+ + + +V I Sbjct: 132 K--RPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDER--------------- 205 ++ G +R++R A + A RK++T K N + + + + Sbjct: 190 PVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFT 249 Query: 206 ------------------VEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFG 247 + AE +I DI + + +P DVV NL G Sbjct: 250 WQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNG 309 Query: 248 DILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMM 307 D +SD A G IGIAP AN+N E T ++FE HG+AP G N NP + I + +M Sbjct: 310 DYISDALAAQVGGIGIAPGANINYE-TGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLM 368 Query: 308 LDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIIL 360 L+ LG +Q+A + I +IE+ IA T D +T AD + K + Sbjct: 369 LEHLG-----WQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK 422 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 116/387 (29%), Positives = 164/387 (42%), Gaps = 52/387 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M RI +PGDGIG EV+ + V+ A + + + G+ +P Sbjct: 5 MLRKRICVLPGDGIGIEVMEAALPVIAAL----NLPFDLVPADI-GWQCWRAEGETVPAR 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVR 110 E ++ DA GA+ + +++ R+ D Y N+RPV Sbjct: 60 TWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVT 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGR-------------------VNEGT 151 G F V+RENTEG Y+ L Sbjct: 120 DMTG---------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + + + + TR G+ RI YAFE A+ +T K L S + EA A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP++ +++D + V +PERF V+VA N+FGDILSDLG G +G APS N Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 + FEPVHGSAP G N ANP A A A+ML+ LG F I A+ Sbjct: 291 SG---AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLG-----FPTESACISQAVSL 342 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKI 358 V +T D+ G+ TT QV +AI + Sbjct: 343 VSRTSTRTYDLGGSHTTAQVGEAIVQQ 369 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 319 bits (818), Expect = 9e-86, Method: Composition-based stats. Identities = 125/356 (35%), Positives = 172/356 (48%), Gaps = 37/356 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+A IPGDGIG EV+ +RVL+A R + FE E + + G + ++ E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYE-GGVDVFQECGSPIREEDLE 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ R DA+ FGA P +P +L R+E Y NLR + P + Sbjct: 57 EIRRSDAVLFGATTTPFDLP---GYRSLILTLRKELGLYANLR---IIPDLRT------- 103 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + +VREN+EG Y +G V + + + TR G +RI R+A E A++R Sbjct: 104 -GREIVIVRENSEGLYFGIGAVV-----NGRAVDVRLITREGAERIARFAVEQAKARG-S 156 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K+N L ++ V +A + ID + V P V+++ N Sbjct: 157 FITFVHKANVL-TGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVILSEN 214 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSDL G+IGI PS N +LFEPVHGSAPDI GK IANPI I +G Sbjct: 215 LFGDILSDLATVHAGSIGIVPSGNYGD---GIALFEPVHGSAPDIAGKGIANPIGAILSG 271 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AM+LD+LG I AA+ + +G TPDM G A T V I I Sbjct: 272 AMLLDYLGLDGS-------LIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIE 320 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 157/360 (43%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PG GIG E + + + G + FE ++ Sbjct: 56 RHAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDPTMDNDDD----VQYAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + + + R E D Y + + +PGV + Sbjct: 108 TTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVAT-----R 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID ++R+NTEGEY+ L G VV V T +R+ R+AFE A+ R Sbjct: 160 HKDIDVVIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAKKNGR 215 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + E +A+ YP+I D ID C + V +P +FDV++ + Sbjct: 216 KKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLMT 275 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G I+S++ G G+ N ++FEP + I GKNIANPIA I Sbjct: 276 NLYGSIVSNVVCGLLGGAGLLSGRNYGDHY---AVFEPGTRNTGTAIAGKNIANPIAMIN 332 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIILR 361 A ML+ LG+ Q + + AI + I TPD+ G+ T+ V AI + + R Sbjct: 333 ASIDMLEHLGH-----QFHASLLRRAINKTINVDRVLTPDLGGSNTSTDVVGAILQNVGR 387 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 318 bits (816), Expect = 2e-85, Method: Composition-based stats. Identities = 103/411 (25%), Positives = 159/411 (38%), Gaps = 65/411 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWA-SCEYYSHHGKMMP 59 + I I GDGIG EV I+V A E+ +G + E + G +P Sbjct: 42 PDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLP 101 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D E L + + P + R+ FD Y N+RPV+ FPG+P PL Sbjct: 102 DQSIEVLRKIRVFLKAPLETP----VGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPL 157 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFT 163 +P +D + RENTE Y+ + + I + Sbjct: 158 R--RPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPIS 215 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA------------- 210 + G RI R A + A R+ +T K N + + E +A Sbjct: 216 KFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFEDE 275 Query: 211 -ENYPE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 Y + + + D + + + + +DV++A NL GD +SD G +G+ Sbjct: 276 LAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLGV 335 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP ++ + + EPVHG+AP GKN NP ATI A +M FLG +++ Sbjct: 336 APGLDVGD---WGMMAEPVHGTAPKYRGKNYVNPTATILALELMFRFLG-----WREVAE 387 Query: 324 GILAAIEEVIAHGPKTPDMKGNAT-------------TPQVADAICKIILR 361 I+ +E G T D+ T T + AD + +II R Sbjct: 388 YIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIKR 438 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 316 bits (810), Expect = 7e-85, Method: Composition-based stats. Identities = 106/380 (27%), Positives = 157/380 (41%), Gaps = 39/380 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+ + I GDG G E++ VL AA GF L ++ A G+++P Sbjct: 1 MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRP-AGQGALRSVGELLPAS 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + R G P + + RRE D Y +RPVR++PG AG Sbjct: 60 TLDSIRRNGVALKGPTTTPI----GVGHRSVNITIRRELDLYACVRPVRVWPG-----AG 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT--------------EHEVVIQESVFTRRGV 167 ID VVRENTE YS L + + + T G Sbjct: 111 AVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPITPGGS 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI+ +A + A+ R+ + + + E + YP+I + +LC Sbjct: 171 RRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPVTVLC 230 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 V P DV+V NL+GD++SD+ A G +G+AP AN+ ++FE HGSAP Sbjct: 231 DSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR---TAVFEATHGSAP 287 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM---- 342 + G N NP A I +G M+LD LG I AA+ V+ G T D+ Sbjct: 288 EFAGSNRLNPTALILSGCMLLDHLGE-----APTAARIRAAVRSVLEEGRSVTFDLLPPD 342 Query: 343 --KGNATTPQVADAICKIIL 360 TT A+A+ + + Sbjct: 343 RAARAVTTTAYAEAVIERLR 362 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 132/370 (35%), Positives = 182/370 (49%), Gaps = 26/370 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPD 60 M RI I GDGIG E++ +RVL A AE + +E +E A + Y G + Sbjct: 1 MTGTRIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAE 60 Query: 61 DWHEQLS-RFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 +L DA G VG PD PD + R D Y N+RPVR +PGVP Sbjct: 61 ADVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSR 120 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + + +D+ +VRENTEG Y+S G V V + TR G R+ R AF LA Sbjct: 121 VRADR---VDYVIVRENTEGLYASRGKGVGNRW---AVTDTLLTTREGTLRVARKAFTLA 174 Query: 179 QSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 R + +T KSN L S ++ E V +A +PE+ + ++ D V+ Sbjct: 175 AGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVELEYRYADAAAQDLVL 233 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 PERFDV+V N GD+LSDLG A G +G+ P+ N+ + FEPVHGSAPD+ G+ Sbjct: 234 CPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD---GAAYFEPVHGSAPDLVGR 290 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA--TTPQ 350 N ANP+ + A AM+LD LG+ DE + A+ V+A G + G Sbjct: 291 NRANPVGQLLAAAMLLDHLGHVDE-----AARLRRAVSAVLAFGTVRIEADGTVLGGAEA 345 Query: 351 VADAICKIIL 360 VADA+ + Sbjct: 346 VADAVIAALQ 355 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 316 bits (810), Expect = 9e-85, Method: Composition-based stats. Identities = 96/407 (23%), Positives = 163/407 (40%), Gaps = 63/407 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG---FALSFEQMEWASCEYYS-HHGKM 57 K I I GDGIG ++ P I+V+ AA E+ +++ ++ Sbjct: 26 PKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTW 85 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P + + + + G + P + + R++ D YV RPVR F GVP Sbjct: 86 LPQETLDAVRDYVVSIKGPLTTP----VGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPS 141 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQ 158 P+ +PGD+D + REN+E Y+ + + +V I Sbjct: 142 PVK--KPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIG 199 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY----- 213 ++ G R++R A + A R ++T K N + + + + +A + Sbjct: 200 IKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAEL 259 Query: 214 ---------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + D + + +++P +DV+ NL GD LSD A Sbjct: 260 LDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEV 319 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G IGIAP ANL+ ++FE HG+AP G++ NP + I + MML +G + Sbjct: 320 GGIGIAPGANLSDS---VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRHMG-----W 371 Query: 319 QQAHNGILAAIEEVIAHGPKTPD----MKGN--ATTPQVADAICKII 359 +A + I+ IA T D M G + + DA+ + Sbjct: 372 TEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 316 bits (809), Expect = 9e-85, Method: Composition-based stats. Identities = 102/417 (24%), Positives = 155/417 (37%), Gaps = 70/417 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ V AA ++ G A Y G+ +P Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D L + G + P I + R++ D Y RPV +PG P P+ Sbjct: 76 DKTLATLREYLVGIKGPLTTPI----GIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 P +++ V RENTE Y+ + V+ E Sbjct: 132 VH--PENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE----- 215 +++G R++ A + A + R TLT K N + + + + AE Y + Sbjct: 190 PISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDKVFTW 249 Query: 216 ---------------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGD 248 + + D + ++ PE F+VV NL GD Sbjct: 250 NQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATMNLNGD 309 Query: 249 ILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML 308 +SD A G IGIAP N+N +T ++FE HG+AP G+N NP + I +GAMM Sbjct: 310 YISDALAAQVGGIGIAPGGNIN-YQTGHAIFEATHGTAPQFAGQNKLNPTSIILSGAMMF 368 Query: 309 DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAICKIIL 360 D+LG + N I I+ I T D +T + + ++I Sbjct: 369 DYLG-----WDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIE 420 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 12/365 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA I GDGIG +V I VL+ A + G A Y+ G + D E Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DAI+ GA+G P + + L+ R F Y +RPV+ +P P LA + Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120 Query: 125 GDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR-- 181 ID ++RE+TEG YS+ + + + V TR+ ++ R+AF LA+ R Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRE 180 Query: 182 --PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 LT K+N S+ ++ + + + + ++ ++D V +P FDV Sbjct: 181 RGHPGRLTCVDKANVF-TSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+A + LF+P HGSAPDI G++ ANP+A Sbjct: 240 LVMENMFGDILSDLAGGLVGGMGMAACGEIGD---TTGLFQPAHGSAPDIMGEDKANPLA 296 Query: 300 TIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAIC 356 I + A+MLD+L A I +A+E H + + G+ T V + Sbjct: 297 AILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKELL 356 Query: 357 KIILR 361 + + Sbjct: 357 GRVAQ 361 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 103/394 (26%), Positives = 167/394 (42%), Gaps = 55/394 (13%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK------- 56 ++ +PGD G +++ + VL + + + + + C + K Sbjct: 14 RYKVCYMPGDDSGFDMMEGALVVLLSM----DLPIDWVRADLGWCMWEKSVNKFGQGDPR 69 Query: 57 --MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 +P + +++ DA A+ V ++L+ R+ FD Y+NLRP + P Sbjct: 70 CNTVPPETIDKIRSSDATLMAAITSKSGV---KGFKSAILQMRQLFDLYINLRPAKTLPD 126 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLG-------------GRVNEGTEHEVVIQESV 161 + PL G ID + RENTE YS++ G +V + V Sbjct: 127 LGSPLKGD--PKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDVAVSWRV 184 Query: 162 FTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP--EIRWD 219 F+ G +RI+R AFE A+S R + K+N + + +A+ Y I Sbjct: 185 FSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQYGITGI 244 Query: 220 KQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLF 279 +++ D + P+ + V+V SN+FGDILSD TG +G APS N+ ++F Sbjct: 245 EENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGEN---TAIF 301 Query: 280 EPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH---G 336 EP GS P + NP A + MML++LG QA I AI EV+ Sbjct: 302 EPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLG-----LDQAGQKIEWAINEVLKENRPK 356 Query: 337 PKTPDM-----------KGNATTPQVADAICKII 359 T D+ + A+T ++A AI + I Sbjct: 357 TLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 104/382 (27%), Positives = 166/382 (43%), Gaps = 43/382 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++ +PGD IG E++ E +++L E G + D Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPG---V 115 + E DA+ G+VG P+ VP +S +L R+ D + N+RP R + Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLN 120 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 PL + +DF +VREN G Y + R V+R R + Sbjct: 121 QSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARVSA 168 Query: 176 ELAQSRPRKT---------LTSATKSNGLAISMPYWDERVEAM-AENYPEIRWDKQHIDI 225 LA++ R + +A K+N LA S +W + +P+I Q D Sbjct: 169 ALARTFGRGKNTDDKSPAIVWNADKANVLA-SGRFWRTVTHDIFEREFPDIELHDQLADS 227 Query: 226 LCARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFE 280 + V P +F+ V+ N FGDILSD+ G++G+ PSA++ E+ ++E Sbjct: 228 MAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYE 287 Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA------ 334 VHGSAPDI G ANPIA I + AM+L + + + + A+ + + Sbjct: 288 AVHGSAPDISGTGQANPIAQILSLAMLLRY----SFSMPRQADLLEDAVRKTLEVREHGG 343 Query: 335 HGPKTPDMKGNATTPQVADAIC 356 G +T D+ G+A+T V DA+ Sbjct: 344 LGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 314 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 100/406 (24%), Positives = 158/406 (38%), Gaps = 62/406 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ + ++ A E+ G + A + G+ +P Sbjct: 36 PDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLP 95 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + + L G +G P + RR FD Y +RPV G P+ Sbjct: 96 QETLDVLKESIVGIKGPLGTP----VGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPI 150 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVN-------------------EGTEHEVVIQES 160 P +D V RENT+ Y+ + EG +V I Sbjct: 151 PN--PERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVK 208 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN-------- 212 + R +R A A +K + K N + + + +AE Sbjct: 209 PMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVV 268 Query: 213 --------YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIA 264 +++ K D + + V++PE +DV++A NL GD +SDL + G G Sbjct: 269 TDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFV 328 Query: 265 PSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 PS N+ +LFE HG+A DI GK IANP++ +GAMML+++G +++A Sbjct: 329 PSGNIGDGY---ALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIG-----WKEAAQK 380 Query: 325 ILAAIEEVIAHGPKTPDM----------KGNATTPQVADAICKIIL 360 + A+ +A TPD+ T + A+ I K I Sbjct: 381 VYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 312 bits (800), Expect = 1e-83, Method: Composition-based stats. Identities = 95/405 (23%), Positives = 154/405 (38%), Gaps = 61/405 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 + +A GDGIG E++ +VL AA ++ G A E G ++P Sbjct: 30 PDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLP 89 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D + G + P + R D Y N+RPV+ + G P P Sbjct: 90 DGTLQAFKLARVNLKGPLTTP----VGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTP- 143 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFT 163 P +ID+ + RENTE Y+ + + I + Sbjct: 144 -HCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPIS 202 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV---------------EA 208 + R +R A E A K +T K N + + + + E Sbjct: 203 KWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEE 262 Query: 209 MAENYPE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + Y I + + D + + + +P ++V+V NL GD +SD A G IG Sbjct: 263 VNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIG 322 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQA 321 +A ++ ++ EPVHGSAP GKN+ NP A I +G +L DF+G + + Sbjct: 323 MAAGLDMGD---GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKL--- 376 Query: 322 HNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIIL 360 + A+++ IAH T D+ +T + D + I Sbjct: 377 --LVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 92/407 (22%), Positives = 151/407 (37%), Gaps = 64/407 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYS-HHGKM 57 I I GDGIG +V P ++V+ AA + + + ++ Sbjct: 24 PNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETW 83 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P++ L + G + P + + R+ D YV RPV+ F GVP Sbjct: 84 LPEETLNILQEYKVSIKGPLTTP----VGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPS 139 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQ 158 P+ +P ++D + RENTE Y+ + + V I Sbjct: 140 PVK--RPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIG 197 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY----- 213 ++ G R++R A + A + ++T K N + + + + +A Sbjct: 198 IKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASL 257 Query: 214 ---------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 EI D + + +++P + V+ NL GD LSD A Sbjct: 258 LHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQV 317 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G IGIAP ANL E ++FE HG+AP GKN NP + I + MML +G + Sbjct: 318 GGIGIAPGANLGDE---VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWLE--- 371 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKII 359 + +L + I T D + + D I + Sbjct: 372 ---ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 143/385 (37%), Positives = 196/385 (50%), Gaps = 35/385 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++ ++A +PGDGIG EV+ L+A G AL ++ W + ++ HG+MMP DW Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEAL---PGPALVLTELGWPAHAWHRDHGEMMPADW 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISL-------WGSLLKFRREFDQYVNLRPVRLFPGV 115 QL+ +DA+ GA+G P D LL+ R+ D + RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 P PL+ + D V+REN+EGEY GGR+ GT E Q VFTR G +RI+R+AF Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAF 182 Query: 176 ELA----------QSRPR---------KTLTSATKSNGLAISMPYWDERVEAMAENYPEI 216 E A PR + TK N + + W E +A YP I Sbjct: 183 ERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPGI 242 Query: 217 RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP-ERTF 275 + ID C +FV QP +FDVVVASNL GDIL+DL G +G+APSANLNP +R+ Sbjct: 243 ATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSV 302 Query: 276 PSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 P LFEP HGSAPDI G + A+P A + A ML+++G D ++ + A+ E IA Sbjct: 303 PPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE 362 Query: 336 GPKTPDMKGNATTPQVADAICKIIL 360 M G +V A+ + I Sbjct: 363 HG----MGGR-GCAEVGRAVAQRIR 382 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 112/373 (30%), Positives = 178/373 (47%), Gaps = 42/373 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG----K 56 M K + A + GDGIG EV+ +RVL+ + L A E + +G Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCE-----AGSEQWDKNGRKDAS 53 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 +PD + L D + G +P + + R++FD Y N+RP + + Sbjct: 54 YIPDVTMKILEETDCCFKGPTTT---IPVPGAPRSVAVTLRQKFDLYANIRPTKTYD--- 107 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 +D RE TEG Y+ + ++ + I TR+G R++ A + Sbjct: 108 ---RLTPDRKLDCVCFREATEGLYTGVEAKI----TDDAAIAIRKITRQGSRRLIDSAVD 160 Query: 177 LAQSRPRKTLTSATKSNGLAISMP-YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 A K + + TK N L + +WDE +A+ +I + +ID + + V+ E Sbjct: 161 WANKFNMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQMVIATE 218 Query: 236 RFD--VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 +F+ V+V++NLF DI+S+L A G+IG+ SAN+ ++FE HGSAP G+N Sbjct: 219 QFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDNY---AMFEAAHGSAPQFAGQN 275 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 NP AT+ +GA M D+LG D R + I AA E+VI G T D+ G+A+T Q+ Sbjct: 276 KVNPTATVLSGAWMADYLGERDVR-----DAIFAATEQVINEGKAVTWDIGGDASTTQMT 330 Query: 353 DAIC----KIILR 361 DAI + + + Sbjct: 331 DAIITYAKEKLRK 343 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 91/409 (22%), Positives = 163/409 (39%), Gaps = 71/409 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEY--YSHHGKMMPDD 61 I I GDGIG ++ P I+V+ +A ++ +++ ++ Y + H ++ P++ Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 62 ------WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 E ++ + G + P + R++ D YV LRPVR + G Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPI----GEGFRSLNVALRQKMDLYVCLRPVRWY-GS 146 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVV 156 P P+ Q +D + REN+E Y+ + + Sbjct: 147 PSPVKEPQ--KVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSG 204 Query: 157 IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENY-- 213 + ++ G +R++R A E A + ++T K N + + + + A+A + + Sbjct: 205 VGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNA 264 Query: 214 -----------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 EI D + +++P + V+ NL GD +SD A Sbjct: 265 QVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAA 324 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G IGIAP ANLN +FE HG+AP G + NP + I + MML +G Sbjct: 325 MVGGIGIAPGANLND---TVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMG---- 377 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKII 359 + +A + I++A+E+ I T D + A + + + Sbjct: 378 -WVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 306 bits (783), Expect = 9e-82, Method: Composition-based stats. Identities = 112/374 (29%), Positives = 175/374 (46%), Gaps = 24/374 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M T IA + GDGIG EV+ E ++VL+ +R + + + Y+ G PD Sbjct: 1 MTTYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYF-AMGHAFPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-----VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + + DAI G +G D G+LL RR ++ + N RPV L G+ Sbjct: 60 ETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGL 119 Query: 116 P--CPLAGKQ-PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL ID ++RE G Y V + + + +I++ Sbjct: 120 AHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVK 179 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 FE++ R +K + + KSN L S W+E VE ++NYPE+ +D + Sbjct: 180 VGFEVSMKR-KKVMHNIHKSNVLKSS-VLWNEIVEEESKNYPEVEVKNILVDAAATYLCL 237 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P FDV+V N+FGDILSD G G++G+ PSA P++++ +EP HGSAPDI GK Sbjct: 238 NPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSY---YEPSHGSAPDIAGK 294 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM-----KGNAT 347 IANP + I + A+ML+ ++ + AA++ V +G T D+ + Sbjct: 295 GIANPYSMIGSVALMLE----MSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVS 350 Query: 348 TPQVADAICKIILR 361 T + D +C + + Sbjct: 351 TAEFGDLVCAELAK 364 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 61/399 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA I GDG+G++V+P +V+ +A + + Q+ + G P + Sbjct: 34 IAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDWFPQETI 93 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P + R+E D +VN+R ++ F +P PL Sbjct: 94 NAVRECKIAIKGPLTTPL----GGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPY 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTR 164 + V+R+++E YS + + +V I ++ Sbjct: 150 L--TNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISK 207 Query: 165 RGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NY---------- 213 G +R++RYA A ++LT K N L + + A+A+ Y Sbjct: 208 EGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQAIDDENGRW 267 Query: 214 --------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 P + + D + + +M PE+FDVV +N GD L+D+ A G +GI P Sbjct: 268 LHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADMLSAQVGGVGIMP 327 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGI 325 +ANLN E + FEP HG+ I G+N ANP ++I + +ML F+ ++ +A N I Sbjct: 328 AANLNNE---VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKFM-----QWHEAANLI 379 Query: 326 LAAIEEVIAHGPKTPDMKG------NATTPQVADAICKI 358 A+E +A G T D+ + A + + Sbjct: 380 ENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 87/374 (23%), Positives = 149/374 (39%), Gaps = 39/374 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ + GD IG EV+ E + + +G + + H + + Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGG-SCLDQHDCPIQES 68 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHI--SLWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 ++ S A+ G+VG P +L+ R+ + Y N+RP ++ Sbjct: 69 TLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L ++ +REN G Y + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI--RWDKQHIDILCARFVMQP 234 LA S + S K+N +A S + E + + +P++ + Q +D P Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN-------PERTFPSLFEPVHGSA 286 + + VV+ NLFGDILSDL G++G+ SA ++ R +++PV GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 PDI GK IANPI + +M + +A + I +AI++ + G T D+ G Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRW----SLGLPKAADAIDSAIKDCLESGQCTRDVGGTL 345 Query: 347 TTPQVADAICKIIL 360 +T Q A+ + I Sbjct: 346 STQQAGSALRQSIQ 359 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 117/361 (32%), Positives = 178/361 (49%), Gaps = 32/361 (8%) Query: 1 MMK--TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M + I I GDGIG+EV+P + VLQA E SF + + A + G + Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTE-KQAGDDTRDQTGAAL 56 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P+ +E + DA FGA G + +L R +VN+RP R +PGV Sbjct: 57 PETTYEAAADADATLFGAAG--------ETAADVILPLREAVGSFVNIRPARAYPGV--- 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + D +RENTEG YS R++ ++ V T +++ YA Sbjct: 106 --DALQPETDLVFLRENTEGVYSGHEDRLS----EDLSTLTRVITTSASEQLAEYACSYV 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R + K+N + + + + V +A + ++ ++ +D R + P +FD Sbjct: 160 TERSIDGFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLNPTQFD 218 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVV NL GD+LSDL G +G+ PSAN+ +LFEPVHG+APDI G IANP Sbjct: 219 VVVCPNLAGDVLSDLAAGLVGGLGLLPSANIG---QTNALFEPVHGTAPDIAGDGIANPS 275 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A+I + M+L++LG D A + A+E V+ GP+TPD+ GNA+T V +A+ + Sbjct: 276 ASILSAGMLLEYLGETD-----AATNVQMAVESVLNSGPRTPDLGGNASTEAVVNAVIEQ 330 Query: 359 I 359 + Sbjct: 331 L 331 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 116/369 (31%), Positives = 178/369 (48%), Gaps = 31/369 (8%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + EG++VL A +E G + E + Y P D ++ D I GAVGW Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 80 PDTVPDHISL---------WGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG-----KQPG 125 PD + + ++ R + Y N+RP++L+PGV + G + G Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK- 184 +D ++RENTEG Y+ GG++ G + +V I V TRR ++++R+AFEL + R + Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 185 ------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +T+ K N L + + + YPEI D +D V QPE +D Sbjct: 181 PKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYD 239 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V V SN+FGDI++DL G +G+A N+ ++FEP+HGSAP GK+ NPI Sbjct: 240 VCVTSNMFGDIVTDLASTLQGGMGMAVGGNIG---KHNAMFEPIHGSAPKHAGKDKVNPI 296 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVA 352 A I + L++L D +A I AA+ EV+ G T D+ GN + +V Sbjct: 297 AMILSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVG 356 Query: 353 DAICKIILR 361 AI + +R Sbjct: 357 SAIAEAAVR 365 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 296 bits (759), Expect = 6e-79, Method: Composition-based stats. Identities = 97/405 (23%), Positives = 159/405 (39%), Gaps = 69/405 (17%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC----------------- 48 ++ +PGDGIG E+ + A + ++ + Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYA----NIPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 49 -EYYSHHGKMMP-----------------------DDWHEQLSRFDAIYFGAVGWPDTVP 84 E G+ P D H+ + + G D Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGPFITRDVSK 154 Query: 85 DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLG 144 + ++ Y ++ PV+ +P P D+D VVRENTE EYS L Sbjct: 155 SIDRMLAL------KYGLYAHVVPVKAPQNLP-PSVFTPFRDVDMVVVRENTEAEYSGLE 207 Query: 145 GRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE 204 +V G VV + TR G RI ++AFE A+ R + + K+N + S + E Sbjct: 208 HQVQPG----VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIE 263 Query: 205 RVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVVASNLFGDILSDLGPACTGTIG 262 + +A+ YP+I++ + +D + V P FD VVV NL+G I+S+ + G +G Sbjct: 264 CCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVG 323 Query: 263 IAPSANLNPERTFPS--LFE-PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQ 319 + N + +FE A DI G+ IANPI I + MLD +G Sbjct: 324 VISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMG-----MN 378 Query: 320 QAHNGILAAIEEVIAH---GPKTPDMKGNATTPQVADAICKIILR 361 N I A++E + + TPD+ G ++ +A+ + I + Sbjct: 379 THANRIKFALKETLLNANPKILTPDIGGTGSSVSFIEAMMRHIPK 423 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 296 bits (759), Expect = 7e-79, Method: Composition-based stats. Identities = 119/364 (32%), Positives = 171/364 (46%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + RI AIPG+GIG EV+ +++LQ A+ GF L W + G P Sbjct: 7 ASYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQ-VDYGWLGATAFEQLGSYFPQAT 65 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLA 120 E D I FGAV G LL+ R+ FD + NLRP+R + L Sbjct: 66 TELCDGADGIVFGAVS-----------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLR 114 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ +D +VRE G Y GR ++ + + + RI R A E AQ Sbjct: 115 PEKIQGLDILIVRELVSGIYFGPSGRSSDERGN-YGYHTMRYYDEEIRRIARKALEQAQY 173 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R LT A K N L +W V+ A +P + + +D L + V+ P+RFDV+ Sbjct: 174 R-RGLLTVAHKENALPH--LHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 +ASNLFGDILSD+G A G+IG+ SA+LN L+E +HG+APDI G IANP+ T Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNA--NGFGLYEAIHGTAPDIAGLGIANPLGT 288 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAI 355 + A +ML G Q + ++A G +T D+ T + D + Sbjct: 289 LGACVLMLQQWGEVQAAQQIIAAQ-----DRILAKGYRTADLFTQGEEILVNTATLVDLL 343 Query: 356 CKII 359 + + Sbjct: 344 LEEL 347 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 296 bits (758), Expect = 9e-79, Method: Composition-based stats. Identities = 95/361 (26%), Positives = 171/361 (47%), Gaps = 31/361 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + + +PGDGIG E++ + I+++++ G+ ++ + ++ Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKS-CIYTGYKINIIYNYIGGIS-IDKFNTPITNNLIS 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + D I+ G VG LLK R++F+ + N+RP++ Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK-----------CPF 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV----VIQESVFTRRGVDRILRYAFELAQS 180 +ID +VRE G Y ++ +++ ++ + + R+ R +F LA + Sbjct: 109 KNIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLALN 168 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R +K L S KSN L + W + + + + Y +++ +ID + +FDV+ Sbjct: 169 R-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFDVI 226 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 + SNLFGDI+SDL TG++G+ PS ++N SLFEP HGSAPDI KNIANP+ Sbjct: 227 ITSNLFGDIISDLCSLLTGSLGMLPSISINN--KSLSLFEPCHGSAPDIANKNIANPVGA 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + + MM +++ + N + +I +V+++G T DMK +T + D Sbjct: 285 LLSLVMMFEYV----LNDFKLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDL 340 Query: 355 I 355 + Sbjct: 341 V 341 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 294 bits (752), Expect = 5e-78, Method: Composition-based stats. Identities = 84/298 (28%), Positives = 130/298 (43%), Gaps = 25/298 (8%) Query: 39 SFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRR 98 FE++ +S + + R G + +P S R Sbjct: 1 DFEEVHVSSNADEEDIRNAI-----MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRT 53 Query: 99 EFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 D Y N+ + PGV + DID +VRENTEGEYSSL G VV Sbjct: 54 SLDLYANVIHWKSLPGVVT-----RHKDIDILIVRENTEGEYSSLEHESVAG----VVES 104 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T+ RI YAF+LAQ RK +T+ K+N + + + + +A YP+I + Sbjct: 105 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITF 164 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 + +D + V +P++FDV+V NL+G+I++++ G G+ AN ++ Sbjct: 165 ENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AV 221 Query: 279 FE-PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 FE + I KNIANP AT+ A MMLD L + I A+ + + Sbjct: 222 FETATRNTGKSIANKNIANPTATLLASCMMLDHL-----KLHSYATSIRKAVLASMDN 274 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 293 bits (750), Expect = 6e-78, Method: Composition-based stats. Identities = 92/359 (25%), Positives = 161/359 (44%), Gaps = 28/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + G GIG E++ +RVL+AA G LS+E +S + ++ D+ Sbjct: 37 KTNVTILTGSGIGPEIMDHTLRVLKAA----GAPLSYEIFALSSKDGSKNND---FDEAL 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P + + FR+ D +V + + FPG+ + Sbjct: 90 TSIRRNRVALKGNIELQSKNP---HIKSRNIIFRKTLDLFVYILFCKTFPGLS-----NK 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G+ID V+R+NTEGEY L G+ V V TR ++R++ +AF+ A + R Sbjct: 142 FGEIDITVIRQNTEGEYLMLEHEPRTGS----VESLKVLTRFNLERLIEFAFDYALTNDR 197 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T +N ++ + ++++YP I+ + +++ + P FDV++A+ Sbjct: 198 KLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVILAT 257 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL G ++S+ G G+ N + + ++FEP I G N ANPIA I Sbjct: 258 NLNGSMISNYLNGMLGGPGLTSGINFSAD--GIAVFEPGARNKGSSIVGLNRANPIAMIM 315 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G +L LG + I ++ + +TPD+ G AT + D I + I Sbjct: 316 SGINLLHHLGY-----NKTAEMIHNSVYATLVYDKIRTPDIGGQATAEETVDHIIRHIR 369 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 118/402 (29%), Positives = 165/402 (41%), Gaps = 65/402 (16%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 RI +PGDGIG E+ ++ W + HG +P + Sbjct: 13 APRRITLLPGDGIGPEITDACRGLIADVFPHWEL-----TETQIGWSQWRAHGNPVPQET 67 Query: 63 HEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 E L R DA A+ P ++ +L+ R+ D + N+RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-T 126 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSS----LGGRVNEGTEH-------------- 153 PG DF +VRENTEG YS + H Sbjct: 127 LPGAAA----------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVA 176 Query: 154 -------EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--------LTSATKSNGLAIS 198 EV + V T R+ R A +LA +R +T A K N L S Sbjct: 177 RAVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDS 236 Query: 199 MPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 VE +AE YP++ +D + D + + V P RFDV++A NL GDILSD+G Sbjct: 237 ARVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLI 296 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +G+A SAN+ ++FEPVHGSAPDI G+ IANP A + + AM + LG Sbjct: 297 GGLGLAASANVGDN---FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSEL 353 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 A + A+ P T D+ G ATT + A+ + Sbjct: 354 APAA-KLREAVYAATRTAP-TLDLGGTATTSEFVAAVRAELG 393 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 289 bits (740), Expect = 9e-77, Method: Composition-based stats. Identities = 97/371 (26%), Positives = 173/371 (46%), Gaps = 40/371 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF--ALSFEQMEWASCEYYSHHGKMMPDD 61 + I GDGIG + + R+L+ + + F+ ++ + E + +P + Sbjct: 41 KIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAE 100 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++L I G P ++ + + R+E D + N+RPVR+ Sbjct: 101 VLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE-------- 152 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ID+ RENTEG Y+ G ++ + +V T G +RI+R AFE A++ Sbjct: 153 ---QGIDWTFYRENTEGAYAV--GSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKAN 207 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV--MQPERFDV 239 + +T+ TK+N + + + + +A++Y +I D +IDI+ A+ + + + F V Sbjct: 208 GKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKDFQV 267 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---AN 296 +V NL+GDI++D G +G A SAN+ S+FE +HGSAP + + A+ Sbjct: 268 MVLPNLYGDIITDEAAEFQGGVGTAGSANIGKRY---SMFEAIHGSAPRMVQEGRDQYAD 324 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE-------EVIAHGPKTPDMKGNATTP 349 P + I AGAM+L +G G + + + A++ +++ G T AT Sbjct: 325 PCSVIRAGAMLLAHIGYG-----KEADKLYQALDICTVTEKKLVITGRNTG-----ATGA 374 Query: 350 QVADAICKIIL 360 + AD I + I Sbjct: 375 EFADYIMETIE 385 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 287 bits (734), Expect = 5e-76, Method: Composition-based stats. Identities = 93/462 (20%), Positives = 156/462 (33%), Gaps = 119/462 (25%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKM-- 57 + I GDG G ++ P +VL AA + + + A E +G Sbjct: 24 PDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQY 83 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P D + + G + P + + R+ FD Y +RP R + G P Sbjct: 84 LPQDTLTAIKEYGIAIKGPLTTPI----GGGIRSLNVALRQIFDLYACVRPCRYYAGTPS 139 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------ 153 P P +D V RENTE Y + + Sbjct: 140 PHKS--PDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIPL 197 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA- 210 + I +R G R++R A + A P++ +T K N + + + + +A Sbjct: 198 DAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELAT 257 Query: 211 -------------------ENYPEIRWDK--QHID------------------------- 224 E P+I ++ + ID Sbjct: 258 QEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTPEKKAQIVKEVETVINSI 317 Query: 225 ---------------------ILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 + + +P+ + ++ NL GD LSD A G +G+ Sbjct: 318 WSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGM 377 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 P AN+ ++FE HG+AP G + NP + I +G MML+++G +Q+A + Sbjct: 378 GPGANIGDS---CAIFEATHGTAPKHAGLDKINPGSVILSGVMMLEYMG-----WQEAAD 429 Query: 324 GILAAIEEVIAHGPKTPDMKG-------NATTPQVADAICKI 358 I + IA G T D+ + AD I + Sbjct: 430 LIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 286 bits (731), Expect = 1e-75, Method: Composition-based stats. Identities = 87/364 (23%), Positives = 153/364 (42%), Gaps = 26/364 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAA--ERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + +PGDGIG ++ + +RV + E + F + + E + +P + Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E D + G P ++ + RR Y +RPVR+ Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE--------- 157 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ REN EGEY + G + ++ + V TR G +RI R AFE A++ Sbjct: 158 --KGIDWTFFRENIEGEY--IWGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNG 213 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ--PERFDVV 240 + +T TK+N + + + + A+ + YP I ++ +D + A+ Q + V Sbjct: 214 KTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 + NL+GDI++D+ G +G A S+N+ + +LFE +HG + N A+P Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQY---ALFEAIHGVGNFLVQHNRAQYADP 330 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 + I A M+ +G +++ Q T D G AT + D + Sbjct: 331 CSLIRAMGEMISHIGYPEKKEQLVKAL--DICTRTERKVVITTDKDG-ATAEEFTDYLLD 387 Query: 358 IILR 361 + R Sbjct: 388 TLQR 391 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 281 bits (719), Expect = 3e-74, Method: Composition-based stats. Identities = 92/361 (25%), Positives = 155/361 (42%), Gaps = 29/361 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ + G G+G++ R+ AA + FE + A H +P + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFE-VHLAGRMALEHGKDALPKATFDA 57 Query: 66 LSRFDAIYF------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + VG P + FRR+ + ++RPV PG+P Sbjct: 58 IRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPS-- 115 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +DF + RE TE Y++ + G VV + T R + AF+ A+ Sbjct: 116 ---RFTGVDFLLFREITEDLYTASEHEIVPG----VVQSFKIVTEAACLRFFKLAFDTAR 168 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RKT+ K+N L ++ + E +A+ YPEI +D C + V +P++F+V Sbjct: 169 KRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEV 228 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + A NL+GD+LSDLG G + + N +++E V+G++ + +++NP+ Sbjct: 229 LAAGNLYGDLLSDLGAGLVGGVSTTAAINKG---NGTTVYEAVYGASHEAVPPDMSNPLP 285 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I +L LG I A+E V+ G +T D+ G ATT DAI Sbjct: 286 LILPAIELLKDLGETGT-----AGRIQKAVETVLLEGRIRTRDIGGTATTTAFTDAIVSR 340 Query: 359 I 359 + Sbjct: 341 M 341 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 277 bits (709), Expect = 4e-73, Method: Composition-based stats. Identities = 95/367 (25%), Positives = 154/367 (41%), Gaps = 17/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + IA IPGDG+G E+ E + L+ A E +G + F + A +P + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEA-IAGTAALDRGQCPLPRE 69 Query: 62 WHEQLSRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 + D+I G AVG + L R ++RP + C Sbjct: 70 SLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 118 PLAGK-QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + + +D ++R+ G ++ G+ + + + R AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFT-TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA SR RK +TS K+ L S W + +E +YPEI + +D + V P+ Sbjct: 189 LAASRKRK-VTSLDKA-ILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDA 246 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+VASN+FGDI++D TG P+ +LN ER +H ++ G AN Sbjct: 247 FDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRAN 306 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPD--MKG--NATTPQVA 352 P+ I A AMML++ + G+ A+ V+ G G A T + Sbjct: 307 PVGMILAAAMMLEY----SFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIG 362 Query: 353 DAICKII 359 +A+ + + Sbjct: 363 EAVRECL 369 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 277 bits (708), Expect = 5e-73, Method: Composition-based stats. Identities = 108/368 (29%), Positives = 177/368 (48%), Gaps = 45/368 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIGKE++P+ ++ + F S E Y + G + D ++L Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTF-----YNISSERYINKGITIKDSEIDEL 58 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +++I+FGA+G P I G +L+ R+E D Y+N+RP F + + Sbjct: 59 KSYNSIFFGAIGDFRVKP-GIMEQGVILRLRKELDLYMNIRPAISFSRITG-------NN 110 Query: 127 IDFYVVRENTEGEYSSLGG-------------------RVNEGTEHEVVIQESVFTRRGV 167 I ++REN E YS + G +N ++ + +R+ + Sbjct: 111 IHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNL 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 R A+++A + +T+T K+N + + W E +E + + ++ D L Sbjct: 171 KRFFNMAYKIADT---ETVTITDKANAVDMYS-LWREIAIEESEP-AGKKINFEYADSLA 225 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P ++ ++A NL+GDILSD+ A G +G APS N+ + S+FEPVHGSAP Sbjct: 226 YNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD---YSSMFEPVHGSAP 282 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 DI GKNIANP+A+I + MML L + + ++E VI +G + GNA Sbjct: 283 DIAGKNIANPVASILSCIMMLKHLNQTET-----AGIMEKSVENVIRNGTIPIESGGNAG 337 Query: 348 TPQVADAI 355 T + + + Sbjct: 338 THEFINKV 345 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 274 bits (702), Expect = 2e-72, Method: Composition-based stats. Identities = 92/367 (25%), Positives = 161/367 (43%), Gaps = 34/367 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS--CEYYSHHGKMMPDDWH 63 ++ +PGDGIG ++ + V + ++ E + E + K +P Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAVL 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E D + G P +L + RR+ Y +RP+R+ Sbjct: 99 EACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE---------- 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ID+ REN EGEY + G ++ I + ++ G +R+ R AFE A+S + Sbjct: 149 -KGIDWTFFRENIEGEY--IWGNKGICVGDDLAIDFKILSKPGAERLFRNAFEYAKSSGK 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE---RFDVV 240 +T ATK+N + + + + AM + YP I ++ ID L A+ + PE V Sbjct: 206 TNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DPEFNAGMQVF 264 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 V NL+GDIL+D+ G +G A S+N+ + ++FE +HG + N A+P Sbjct: 265 VLPNLYGDILTDIAAEYQGGLGTASSSNIGDQY---AMFEAIHGVGVYLVEHNRAQYADP 321 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIE---EVIAHGPKTPDMKGNATTPQVADA 354 + I A M+ F+G ++R + + A++ +V T D G AT + A+ Sbjct: 322 SSLIRAMGEMMAFIGYPEKR-----DRLFKALDFCTKVERKAVITTDKDG-ATAEEFAEY 375 Query: 355 ICKIILR 361 + + + + Sbjct: 376 VVETLHK 382 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 274 bits (701), Expect = 3e-72, Method: Composition-based stats. Identities = 78/359 (21%), Positives = 160/359 (44%), Gaps = 37/359 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 KT ++ I G+G+G+E++ V+ A + ++ + E+ + + + Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEV 136 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L G V + R++F Q+ + G+ P Sbjct: 137 LKSLRANKVGIKGPVDSRHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY--- 183 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 GD D ++R+ EG+YS + V G V+ V T G RI + F A Sbjct: 184 --GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNK 237 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T A K+N + ++ + E + A A+ + ++ ++++++D + +++P + DV+V Sbjct: 238 RKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMV 297 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +S+++GD+L + G GI P +++ T +F+ + + GK++ANP + Sbjct: 298 SSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT---VFDCRMKACHALAGKDLANPTGPL 354 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + A+ML + + + + + AI +V +TPD+ G A + A+C + Sbjct: 355 LSAALMLRHV-----KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 272 bits (697), Expect = 1e-71, Method: Composition-based stats. Identities = 117/376 (31%), Positives = 176/376 (46%), Gaps = 29/376 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IA IP DG+GK+V+P G + +Q A E GF L E A EY GKM D Sbjct: 1 MKKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE-AGVEYAVKTGKMCED 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + E +++ DA+ G+ G D P + + L R + LRP+RL G Sbjct: 60 NLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + CPL + +ID +VR+ EG Y G + + V TR ++ Sbjct: 120 IDCPLRNR--EEIDVLLVRQLAEGFYIRPGHMIG----EDAAYDTIVVTRNVTEKFADTC 173 Query: 175 FELAQSR------PRKTLTSATK-SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 F LA+ R +K +T K N ++ + ++ YP+I +D L Sbjct: 174 FRLARGRHGRRQDGKKMVTLGNKHGNV--TCFDFYRKIFTEVSAGYPDIGLQFTQVDALA 231 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P+RFDV+ N+ GDI+ D+G TG +GI P+A++ F P HG+ P Sbjct: 232 EHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVG---GVTPQFRPNHGTFP 288 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAH-GPKTPDMKG 344 GK ANP+A+I ++LD LGN D+ ++ I A+E + GP+T D+ G Sbjct: 289 RAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGG 348 Query: 345 NATTPQVADAICKIIL 360 A T A+A+ K + Sbjct: 349 TANTFATAEAVFKAME 364 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 271 bits (692), Expect = 3e-71, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 150/359 (41%), Gaps = 21/359 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG+G+G EV+ + +L+ E G + G+ + + Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV---- 85 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAGKQP 124 F A F G P + RR FD Y L P+R +P + L + Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAA 142 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VREN G Y G EG Q + V+RILR A LA R R Sbjct: 143 RSADVLIVRENASGLYCGEWGSEGEGA-ARSAYQVCRYRADEVERILRTALRLAGQR-RG 200 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L TK G+ W + + A+A + +R +D + + P +FDV+V N Sbjct: 201 DLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPN 260 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDIL D G G+ G++ S N ++++ HG+A D+ G++ ANPI + + Sbjct: 261 MFGDILGDCGSLLMGSRGMSWSGNYGA--AGQAVYQTAHGAAWDLAGRDRANPIGQVCSL 318 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAICKII 359 AMML R + + AI +A G +T D++G T + A+C + Sbjct: 319 AMMLR----ESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQALCASL 373 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 269 bits (689), Expect = 8e-71, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 112/258 (43%), Gaps = 31/258 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ I GDG G E+ RVL+A G A ++ + A + G +PD E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA----TGVAFDWDIQD-AGVDVMEQLGTPLPDSVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + P + R+E D Y +RP R +PGV + Sbjct: 58 SIRSTKVALKAPITTP----VGTGFRSVNVAIRKELDLYACVRPCRSYPGVRS-----RF 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-----------------VIQESVFTRRGV 167 +ID VVRENTE Y+ + E+ I + G Sbjct: 109 ENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGS 168 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 +RI+R+AFE A++ RK +T+ K+N + S + E +A+ YP+I +D + +D +C Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMC 228 Query: 228 ARFVMQPERFDVVVASNL 245 + V +PE +DV+V NL Sbjct: 229 MQLVQKPELYDVMVLPNL 246 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 267 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 110/371 (29%), Positives = 157/371 (42%), Gaps = 72/371 (19%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+RI IPGDGIGKEV+P G R+L+A G F + A E + G +PD Sbjct: 4 RTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLH-AGFETFERTGAALPDKT 62 Query: 63 HEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L D FGAV P + ++ R++ D Y N+RPV+ P Sbjct: 63 VEILRNECDGALFGAVSSPSSPV--KGYSSPIVALRKKLDLYANVRPVKTVLSAAKP--- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ID +VRENTE Y + V + R RI A ++A R Sbjct: 118 -----IDMVIVRENTEDLYVKEETTRDTPDGK-VAEAIKRISERASHRIATMAGDIALRR 171 Query: 182 PRKT------------LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 + +T KSN L + Sbjct: 172 QKIRAAGAPSIHQSPLVTITHKSNVL-----LRLK------------------------- 201 Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 +V+V NL+GDILSD A G++G+ PSAN+ ++ EP HGSAPDI Sbjct: 202 --------NVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE---GFAIGEPCHGSAPDI 250 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATT 348 G+NIANPIAT+ + A+ML+FL + ++ + G +PD+ G A T Sbjct: 251 MGQNIANPIATLRSAALMLEFLDEEAAAAKIYAA-----VDANLTEGKLLSPDLGGTAKT 305 Query: 349 PQVADAICKII 359 +V + I + + Sbjct: 306 TEVIEDILRRL 316 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 261 bits (668), Expect = 3e-68, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 143/360 (39%), Gaps = 30/360 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M I + GDGI +E+ V A F + F ++ S E G + D+ Sbjct: 6 MNRYSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDL-SDESREAKGDAIYDE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + R+ R + V RPV PG+ Sbjct: 61 AEAAMRRYGTSLKYPTATTK--------ESPNRVLRERCNFAVIHRPVATIPGIQTHYN- 111 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 I +VR T G Y G R+N + + RR R+AF LAQ R Sbjct: 112 ---ERIHLDIVRIATGGTYEDAGRRINR----DTAVSIRAIERRPSVLASRFAFRLAQLR 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + + +K + + E +A +YP + ++ D L A +M+PER+ V+V Sbjct: 165 D-SNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTF---PSLFEPVHGSAPDIYGKNIANPI 298 N +GD LSD+ G+IG+ SA+ + + ++F+P G+APDI G+N ANP Sbjct: 224 CPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPT 283 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A + A A ML +G D + A+ I G KT D+ G+ + I Sbjct: 284 AALLAMANMLRHIGEHDS-----SKALRGALFGAIEAGEKTADIGGSLNLSEFTQVIVDR 338 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 260 bits (665), Expect = 5e-68, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 145/370 (39%), Gaps = 34/370 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +R+ I G G G VL ++ +AA + ++ + + + + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAAL----VPVEWDYQTLSVYRDHKTNRMTVNPQL 94 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + P SL L + + +V +R G + Sbjct: 95 LDSAIETGLVLCAKDSSPRQND---SLESDSLALHKALNAFVGVRKFNSVVG------HE 145 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 G I+ +RE+ GEYS + V+ G VV +++ + + AF+ A Sbjct: 146 PYGPINLVNIREHVSGEYSEIEHLVSPG----VVQSIKTVSKKISVEVAKLAFDYACKHG 201 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +T K++ + +S + + ++ YP++ ++++ +D C P R++V++ Sbjct: 202 HSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRYEVLLT 261 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP------VHGSAPDIYGK---- 292 ++L+G + +G + P+ P+ T S H I+ K Sbjct: 262 TSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYG 321 Query: 293 --NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 I NP I A A+MLD G A I AA+E+ I G +T DM G+A+ Q Sbjct: 322 QEQIINPTGIIRAAALMLDHAG-----MVVAGRCIAAAVEDTIRQGIRTQDMGGDASCSQ 376 Query: 351 VADAICKIIL 360 DAI K + Sbjct: 377 FTDAIIKNLK 386 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 259 bits (661), Expect = 2e-67, Method: Composition-based stats. Identities = 110/346 (31%), Positives = 172/346 (49%), Gaps = 47/346 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A IPGDGIG+E++P AAA ++F + +S E Y G ++ DD E+L Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDISS-ERYIKTGIIIKDDELEEL 57 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + AI FGA+G P P I G +L+ RRE + Y+N+RPVR F Sbjct: 58 KNYRAILFGAIGDPRVRP-GIMEQGVILRLRRELELYMNIRPVRSFDD-----------K 105 Query: 127 IDFYVVRENTEGEYSSLGG---------------RVNEGTEHEVVIQESVFTRRGVDRIL 171 I ++RENT+ Y+ + G ++ + EV + + R + + Sbjct: 106 IKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFF 165 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 AF + T+T K+N + + W A I ++ D L + Sbjct: 166 NKAFSIC----DSTVTVTDKANAVKMYN-LWRSTAMEAAIE-KNINISFEYADALAYNMI 219 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + P+++ ++A NL+GDI+SD+G A G +G APSAN+ + +LFEPVHGSAPDI G Sbjct: 220 LNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDK---NALFEPVHGSAPDIAG 276 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 +++ANP A+I AG+M+L++LG DE I + + +G Sbjct: 277 RDMANPAASIMAGSMLLEYLGYRDE-----SRIINDMVRNLYINGV 317 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 92/362 (25%), Positives = 147/362 (40%), Gaps = 17/362 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 T I + GD G+E+L + +RVLQ + R L F + S E + + Sbjct: 4 TTPTIVVMHGDQTGEELLIQALRVLQPSVIR--QPLQFLDYDL-SLENRRATDNKVVWEA 60 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A P+ D R + V LR R P + P+AG Sbjct: 61 AQAARDSGLSLKAATITPEIAGDVG---SPNAILREALNAKVILRTGRRIPKI-RPIAGV 116 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +VR + Y S R E+ + S +R + + F+ A R Sbjct: 117 YSP---IAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFTFQYA-KRT 172 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 + + K A + E ++A A+ YPE+ + ID A + V+ A Sbjct: 173 KAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTGESLVIPA 232 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPI 298 N GD+LSD+ G+I + S L ++ + E HG+AP ++GKNIANP+ Sbjct: 233 LNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPM 292 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A I AGA +L + + ++A I ++ E I G TPD+ G TT + D + + Sbjct: 293 AMILAGAALLSY--GRIPQAEKASRAIYESVFETIYEGKATPDLGGQMTTSEFTDEVIRR 350 Query: 359 IL 360 + Sbjct: 351 VE 352 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 257 bits (658), Expect = 4e-67, Method: Composition-based stats. Identities = 125/337 (37%), Positives = 169/337 (50%), Gaps = 52/337 (15%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IAAI GDGIG EV+ G + A ++ W + S Sbjct: 16 YKIAAIRGDGIGPEVIEAG---------NYQSAEETNRVAWILLNWPSRT---------- 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLR------PVRLFPGVPCP 118 GAV D + S + F Y+ LR P R+F G+ P Sbjct: 57 --------LSGAVRITRNTADISPISSSTFLW---FSSYLPLRSSTSNMPTRVFHGIQSP 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D+ +VREN+EGEY+ GGR G EV S+FTR GV+RI+++AFE A Sbjct: 106 L------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAA 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVE-AMAENYPEIRWDKQHIDILCARFVMQPERF 237 +SR +K +T ATKSN + WDE +A +P++ DK +D + AR V+ PE Sbjct: 160 RSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPESL 219 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +NL ILSDL A G+IGIAP++NL+P R PS+FEPVHGSA DI GK++A Sbjct: 220 DTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA-- 277 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 T W A ML +LG A +L +E V Sbjct: 278 --TFWTVAEMLSWLGQKG-----AAAELLECVESVCK 307 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 257 bits (656), Expect = 6e-67, Method: Composition-based stats. Identities = 101/368 (27%), Positives = 143/368 (38%), Gaps = 45/368 (12%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF--ALSFEQMEWASCEYYSHHGKMMP 59 M T I GD G EV+ E ++VL+A + ++ H + Sbjct: 1 MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGAS-IKVHNDPLT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHI-SLWGSLLKFRREFDQYVNLRPVRLFPGV--- 115 DAI GA+G P+ P LL+ R+E Y NLRP Sbjct: 60 AKALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVD 119 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 PL DF VVRE T G Y E + ++R ++RI R A Sbjct: 120 SSPLKADVCRGTDFIVVRELTGGIYFGA---RTEDDGSGFAMDTDAYSRAEIERIARLAG 176 Query: 176 ELAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 LA + P + S K+N LA S + E A +P++ Q ID V P Sbjct: 177 FLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSP 236 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 + VVV SNLFGDI+SD G+IG Sbjct: 237 RALNGVVVTSNLFGDIISDEASVIPGSIGA-----------------------------G 267 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVAD 353 I NPI TI + AMML + + + AA+ + +G +T D+ G+A T Q+AD Sbjct: 268 IVNPIGTILSVAMMLRY----SLNLPKEAAAVEAAVRTALDNGTRTKDLGGSAGTFQMAD 323 Query: 354 AICKIILR 361 A+ +++ Sbjct: 324 AVVVELVK 331 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 253 bits (647), Expect = 7e-66, Method: Composition-based stats. Identities = 95/458 (20%), Positives = 151/458 (32%), Gaps = 120/458 (26%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKM--MPDDW 62 I I GDG G ++ P V+ AA + +G + A E +G P+D Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + P + + R+ FD Y +RP R +PG P P Sbjct: 89 LTAIKEYGVAIKGPLTTP----VGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + I Sbjct: 143 TPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRLDSGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA------ 210 ++ G R++R A A+ P+ +T K N + + + + +A Sbjct: 203 IKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELATTEFRA 262 Query: 211 --------------ENYPE--IRWDKQHID-----------ILCARFVMQP--------- 234 E+ P+ I + ID + + V Q Sbjct: 263 ECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLTEEKQAVIKQEVEQVLNSIWESHG 322 Query: 235 ---ERFDVVVASNLFGDI-----------------------LSDLGPACTGTIGIAPSAN 268 + V+V + I LSD A G +G+ P AN Sbjct: 323 NGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGAN 382 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + ++FE HG+AP G + NP + I +G MML+F+G +Q+A + I Sbjct: 383 IGDS---AAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMG-----WQEAADLIKKG 434 Query: 329 IEEVIAHGPKTPDMKG--------NATTPQVADAICKI 358 I IA+ T D+ + A AI Sbjct: 435 IGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 249 bits (637), Expect = 9e-65, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 152/365 (41%), Gaps = 17/365 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++I + GD G+E+L + +RVL E G L E+ + S E + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDL-SLENRRATQNGVVS 57 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D + A P+ D R E D V +R R PGV P+A Sbjct: 58 DAAAAMRTCGFGIKAATITPEGADDVG---SPNRILREEVDGKVIVRTGRRIPGV-TPIA 113 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +VR E Y + R + G EV + TR + YAF A+ Sbjct: 114 GVHYP---ISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEYAFRTAR 170 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QPERFD 238 + + K + E ++A A +P++ ++ ID A V + Sbjct: 171 AMQ-ARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGAADEPL 229 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNIA 295 VV A N GD LSDL G+I A S L + T ++ E HG+AP + GK++A Sbjct: 230 VVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVA 289 Query: 296 NPIATIWAGAMMLDFLGNG-DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NP+A + A +L ++A I ++ E IA G KTPD+ G+A T + DA Sbjct: 290 NPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTDA 349 Query: 355 ICKII 359 + + I Sbjct: 350 VIERI 354 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 249 bits (635), Expect = 1e-64, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 147/342 (42%), Gaps = 37/342 (10%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + V+ A + ++ + E+ + + + + L G V Sbjct: 1 MDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS 52 Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 + R++F Q+ + G+ P GD D ++R+ EG+ Sbjct: 53 RHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGD 97 Query: 140 YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 YS + V G V+ V T G RI + F A RK +T A K+N + ++ Sbjct: 98 YSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTD 153 Query: 200 PYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + E + A A+ + ++ ++++++D + +++P + DV+V+S+++GD+L + Sbjct: 154 GNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMM 213 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G GI P +++ T +F+ + + GK++ANP + + A+ML + + Sbjct: 214 GVPGICPGYSVSSLGT---VFDCRMKACHALAGKDLANPTGPLLSAALMLRHV-----KM 265 Query: 319 QQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + + + AI +V +TPD+ G A + A+C + Sbjct: 266 DKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 249 bits (635), Expect = 1e-64, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 143/327 (43%), Gaps = 35/327 (10%) Query: 19 VLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVG 78 ++ ++V + ++ + S G+ + E L R G Sbjct: 1 MIESLVKVFSTVQ----VPIDWDVFH--EHKINSAEGEDVSPKLLESLCRNKIGIKGPFE 54 Query: 79 WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEG 138 L K R++F + + R G + G +D ++R+ EG Sbjct: 55 SGPC----------LRKLRKKFQLFAFVAVCRNLEG-----QNTRYGKLDCLIIRDQVEG 99 Query: 139 EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAIS 198 EYS + RV G V+ V T G DR+ RY FE A+ RK +T A K+N + ++ Sbjct: 100 EYSGIEHRVVPG----VMQTIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLT 155 Query: 199 MPYWDERVEAMAENYP-EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + + A Y +I ++++++D +C +M+PER DV+VAS+++GD+L+ + + Sbjct: 156 DGTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASI 215 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDER 317 G + P + P ++EP+ + +I GK+I NP + +G +ML + + Sbjct: 216 MGGPALCPGFAVGPMGL---IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLR-----EMK 267 Query: 318 FQQAHNGILAAIEEVIAH-GPKTPDMK 343 + + I A+ V +T D+ Sbjct: 268 LNEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 237 bits (606), Expect = 4e-61, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 145/342 (42%), Gaps = 45/342 (13%) Query: 18 EVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAV 77 E+ + LQ A G ++++ ++ ++P+ + + G + Sbjct: 12 ELGAQVTNALQMAIAATGVDITWQIVDIGG----EDQQGLLPNYIFDIIRTAKTAVIGPL 67 Query: 78 GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE 137 PD + R + D YVNLRP + G+P ++D +VRE TE Sbjct: 68 MMPD------NYRQMEADIREKLDLYVNLRPAKTMVGIPSNY-----QNVDIMIVRETTE 116 Query: 138 GEYSSLGGR----------------VNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G Y+ + + + + + +G +I+ +AF A+ Sbjct: 117 GIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKT 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R + + +++ +A + + E +A+ +P+I + + I+++C + +PERFDV+V Sbjct: 177 KRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GD+L+ L G + + P A++ + + D G + P + I Sbjct: 237 MPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVFG----AQSTGTDDVGHD---PTSLI 288 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM 342 AGA+ML LG Q+A + AA+E V+A T D+ Sbjct: 289 LAGALMLRHLGE-----QEAAQRLQAAVEAVVASHVDTTADL 325 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 232 bits (593), Expect = 1e-59, Method: Composition-based stats. Identities = 75/359 (20%), Positives = 127/359 (35%), Gaps = 31/359 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + ++A +PGDG G + R L R + + ++ + G +P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---PCP 118 + DA+ G P I LL R+E + VN+RPVR Sbjct: 68 TLGACRQSDAVLVCGCGDPRY---GIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + +D R+ T G Y + E + ++R+ ++RI R A A Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGE---AYDTTPYSRQTIERIARLAGTYA 181 Query: 179 QS-RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 P K + S K N +A S + +P++ +D P Sbjct: 182 MQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDPLSL 241 Query: 238 D-VVVASNLFGDILSDLGPACTGTIGIAPSANL-----NPERTFPSLFEPVHGSAPDIYG 291 + +++ N+FGDILSD G+ + SA + R P +FEP + + G Sbjct: 242 NGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNP----G 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA------HGPKTPDMKG 344 P+ +I A +ML+ + AI + +T D+ G Sbjct: 298 GKTVGPLGSIQAVGLMLE----LSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 230 bits (586), Expect = 8e-59, Method: Composition-based stats. Identities = 97/364 (26%), Positives = 146/364 (40%), Gaps = 31/364 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +R+A +PGDG+G+EVL R+L+ AER ++ + G ++P Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTGPWP--VGARAAAETGDVLPAGTLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDH--ISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI GAVG VP +L + R +D +++R + G Sbjct: 60 ACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGRE------ 113 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 VVR G Y RV E TR V ++ A ++ R Sbjct: 114 ------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLGRRG 166 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L S K+N L + W + +A I + +++D DV+V Sbjct: 167 GGRLVSVDKAN-LYATGRLWRQVAGDVARE-RGIEVEHRYVDRAAFELGSGAPVPDVLVT 224 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGKNIANPI 298 L GDILSDL G+ + SA+L+P LFEP HGSAP ++ +P+ Sbjct: 225 EGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPL 284 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 A A +L ++A + AA+ V+ GP T D+ A+T QVADA Sbjct: 285 GGFLALAALLRHF----PATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVADA 340 Query: 355 ICKI 358 + Sbjct: 341 VLAA 344 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 229 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 109/351 (31%), Positives = 162/351 (46%), Gaps = 21/351 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T R+ G+GIG E++ ++ ++ A + G A E + G+++P++ Sbjct: 5 ETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEET 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E ++ D G P R++ D + N+RPVR PG Sbjct: 65 WETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPG-------A 117 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQ 179 D+D +VRENTEG Y+ + G EV + VFT+ + RI+R A Sbjct: 118 VHPDLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRA-AAIA 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + LT A KSN L + + +A AE + + HID LCA V +PER+ Sbjct: 177 AARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTRPERYAT 235 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +VA N+FGDILSDL G++GIA S N + + + + HGSAPDI G+ IANP Sbjct: 236 IVAENMFGDILSDLAGGLGGSLGIAGSINASESQ---VMAQAAHGSAPDIAGQGIANPAG 292 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 + + A MLD LG QA + A+ E + P T D+ A Sbjct: 293 IMNSAAQMLDSLGY-----PQAAELLEGAVREAVVKAP-TADLVREAAAAD 337 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 226 bits (577), Expect = 8e-58, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 122/416 (29%), Gaps = 67/416 (16%) Query: 3 KTMRIA--AIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++A + D G E+ + ++ + + + + Sbjct: 42 KRIKVAKPVVEMD--GDEMTRIIWQFIKEKLILPHVDIQLKYFDL-GLPNRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D ++ A PD R V P+ + + Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPI-ICKNI 157 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQES--------------- 160 P + G + R +Y + + ++V Sbjct: 158 PRLVPGWTKP---ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA 214 Query: 161 -------VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 T + F+ A + L +TK+ L + + + + ++ Sbjct: 215 GGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEIFDKH 273 Query: 213 YP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y +I ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 274 YKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTS 332 Query: 267 ANLNPERTFPSLFEPVHGSAPDIY---GKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K NPIA+I+A L+ G D + Sbjct: 333 VLVCPDGKTI-EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 391 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGN-------------ATTPQVADAICKIILR 361 + + E + G T D+ G T D I + R Sbjct: 392 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDR 447 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 222 bits (567), Expect = 1e-56, Method: Composition-based stats. Identities = 66/418 (15%), Positives = 128/418 (30%), Gaps = 70/418 (16%) Query: 1 MMKTMR---IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M K + + + GD E+ +++ L + E Sbjct: 1 MSKKISGGSVVEMQGD----EMTRIIWELIKEKLIFPYVELDLHSYDL-GIENRDATNDQ 55 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLF 112 + D E + + + A PD R V R + Sbjct: 56 VTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVF-REAIIC 114 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR------- 165 +P ++G + R +Y + V + E+ S T++ Sbjct: 115 KNIPRLVSGWVKP---IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHN 171 Query: 166 ----------------GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 ++ +F++A S+ L +TK+ L + + + + Sbjct: 172 FEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEI 230 Query: 210 -AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + Y +I ++ + ID + A+ + F + N GD+ SD G++G Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLG 289 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ + NPIA+I+A L D Sbjct: 290 MMTSVLVCPDGKTV-EAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDN 348 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMKG------------NATTPQVADAICKIIL 360 + N + E I G T D+ T + D + + + Sbjct: 349 NKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 216 bits (551), Expect = 8e-55, Method: Composition-based stats. Identities = 65/418 (15%), Positives = 118/418 (28%), Gaps = 69/418 (16%) Query: 2 MKTMRIAA----IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M +I + D G E+ + ++ L + + Sbjct: 1 MAFQKITVQNPIVEMD--GDEMTRVIWKSIKDKLILPFLELDIKYFSL-GLPHRDATDDK 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLF 112 + + E +++ A PD R + V P+ + Sbjct: 58 VTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPI-MC 116 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSL-----------------------GGRVNE 149 +P + G + R +Y + V Sbjct: 117 KNIPRLVPGWTKP---ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYN 173 Query: 150 GTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 T V T V + +A + L +TK+ L + + + + Sbjct: 174 FTGAGGVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKDIFQEV 232 Query: 210 AE-------NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 E I ++ + ID + A + + V N GD+ SD G++G Sbjct: 233 YEANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLG 291 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY------GKNIANPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ N IA+I+A L D Sbjct: 292 LMTSVLVCPDGKTI-EAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDN 350 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMK-----GN-------ATTPQVADAICKIIL 360 ER + AA + G T D+ G+ T + DA+ + Sbjct: 351 NERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELK 408 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 67/414 (16%), Positives = 130/414 (31%), Gaps = 65/414 (15%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 + +++ + D G E+ +++ + + S ++ + Sbjct: 180 QRIKVDQPVVEMD--GDEMARVIWAMIKEKLILPYLDIPLMYYDL-SIQHRDKTDDQVTI 236 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D + R A PD R D + P+ L V Sbjct: 237 DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPI-LMKNV 295 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVN---------------EGTEHEV----- 155 P + + R +Y +L V+ HEV Sbjct: 296 PRLVPSWTKP---IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKG 352 Query: 156 -VIQESVF-TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 + ++ T + F+ A + + L +TK+ L + + + + + Sbjct: 353 GGVALGMYNTDASIKGFAHSCFQYALDQ-KMPLYLSTKNTVLKKYDGRFKDIFQTIYEKE 411 Query: 213 YP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y + ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 412 YKQKFEEAGLWYEHRLIDDMVAQAIKSSGGF-VWACKNYDGDVQSDVVAQGYGSLGLMTS 470 Query: 267 ANLNPERTFPSLFEPVHGSAPDI---YGKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K I NPIA+I+A L D ++ Sbjct: 471 VLVCPDGKTI-EAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKL 529 Query: 319 QQAHNGILAAIEEVIAHGPKTPDM-----KGNAT------TPQVADAICKIILR 361 ++ + A E + G T D+ T T D + ++ R Sbjct: 530 KEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRDYLCTEDFMDKLARVAER 583 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 214 bits (545), Expect = 4e-54, Method: Composition-based stats. Identities = 68/378 (17%), Positives = 130/378 (34%), Gaps = 44/378 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 + I I GDGIG E+ I V+ +A E G E Y G +P Sbjct: 21 PDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVP 80 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 +D +++ + + +PD R+ Y N+R ++ G+ P+ Sbjct: 81 EDSIKEIQKMYIAMK---STLNFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMDIPV 134 Query: 120 AGKQPGDIDFYVVR-------------ENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRG 166 ++ ++R E+T+ + + I ++ Sbjct: 135 N--TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFR 192 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +I + A ++ +K +T + + A ++ ++ Sbjct: 193 TRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEASAQEDVGYEVLKTREF 247 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 R + PE F+V++ N+ L D GTI I +++ E ++FE V S Sbjct: 248 MKRLISSPEDFEVILVDNVLSQTLVDYLA---GTINIEYGSSIGDE---CAVFEAVQSSL 301 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK--- 343 P G + A+P++ I +G ML +G + +A I AI D+ Sbjct: 302 PSEAGYDAADPLSFILSGCEMLMHIG-----WVEAAQIIENAISAAFRDNKIPKDINTRP 356 Query: 344 --GNATTPQVADAICKII 359 + + I K + Sbjct: 357 DISPIKCSEFSSEIIKRM 374 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 211 bits (538), Expect = 3e-53, Method: Composition-based stats. Identities = 90/255 (35%), Positives = 125/255 (49%), Gaps = 19/255 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG E++ + VL+AAA R L F + A + + G M E++ Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSED-AGADAFRRTGSAMSAATLERI 66 Query: 67 S-RFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 R+ + G VG P PD R D Y N+RP+ L PGV PL G Sbjct: 67 RTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTA- 125 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESV-FTRRGVDRILRYAFELAQSR-- 181 +D+ +VRENTEG Y S G ++ + + TR GV+R++ +AFELA R Sbjct: 126 --VDYVIVRENTEGLYLSR----GRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTG 179 Query: 182 ----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + +T KSN L S ++ E + +A YP++ D ++ D V P RF Sbjct: 180 APADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRF 238 Query: 238 DVVVASNLFGDILSD 252 DV+V N GDILSD Sbjct: 239 DVLVMENFLGDILSD 253 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 207 bits (528), Expect = 5e-52, Method: Composition-based stats. Identities = 69/361 (19%), Positives = 126/361 (34%), Gaps = 68/361 (18%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + + I V +V+ A + FE + + Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQA----PVYFETYIIKG-----KNMNHLTW 44 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + + + G V R+E D + +L G P Sbjct: 45 EVVDSIRKNKVCLNGRVNNSLCGGA-----------RKELDLFASLVDCFNLNGQPS--- 90 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + ++D V+RENTEGEY+ V G + T+ DRI +YAFE A Sbjct: 91 --RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVTM---TKFWSDRIAKYAFEYAHF 145 Query: 181 RPRKTLTSATKSNGL-AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 RK +T+ + ++ ++ E + +A+ YP I +++ +R R Sbjct: 146 SKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEI-----ASRETRAIRRHS- 199 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 S I++++ G + + ++FE V N NP+A Sbjct: 200 --NSKSLWAIIANIASGVAGG-------SFGDDY---AIFEQVGSVG------NHKNPVA 241 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +++ MML L + + A+ VI+ G N TT +V D++ + Sbjct: 242 LLFSSVMMLRHL-----LLPLFADRLKTAVTRVISEGKCG---NSNTTTQEVVDSVIANL 293 Query: 360 L 360 Sbjct: 294 D 294 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 65/386 (16%), Positives = 129/386 (33%), Gaps = 50/386 (12%) Query: 2 MKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M +++ + D G E+ +V++ + + + EY + Sbjct: 7 MNKIKVKNPVVELD--GDEMTRIIWQVIKDKFIHPYLDIDLKYYDL-GLEYRDETNDQVT 63 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPG 114 D E + ++ A PD R V P+ + P Sbjct: 64 LDAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPA 122 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 +P + + + R +Y + ++ E+V + V ++ + Sbjct: 123 IPRLVPSWKQP---IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKG-GKPEVIKVYDFP 178 Query: 175 FE--LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 E +AQ++ K I + + EA I ++ + ID + A+ + Sbjct: 179 AEGGVAQTQF--------KDIFQEIYEAQYRKEFEA-----AGIWYEHRLIDDMVAQMIK 225 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-- 290 + ++ N GD+ SD+ G++G+ S + P+ E HG+ Y Sbjct: 226 SEGGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTF-EAEAAHGTVTRHYRE 283 Query: 291 ---GKNIA-NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVI-AHGPKTPDMK 343 G+ + NPIA+I+A L G D + A + + G T D+ Sbjct: 284 HQKGRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLA 343 Query: 344 ---GN------ATTPQVADAICKIIL 360 G TT + DA+ + + Sbjct: 344 LAQGKKDRSAWVTTNEYLDAVERRLK 369 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 62/377 (16%), Positives = 116/377 (30%), Gaps = 59/377 (15%) Query: 36 FALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLW 90 + EY + + E + ++ A PD Sbjct: 90 IPIQLPGHRPQGIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWL 149 Query: 91 GSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEG 150 R V P+ + P +P + G + R +Y + + Sbjct: 150 SPNGTIRNILGGTVFREPI-VIPAIPRLVPGWTKP---IIIGRHAFGDQYRATDRVIPGP 205 Query: 151 TEHEVVIQ----------------------ESVFTRRGVDRILRYAFELAQSRPRKTLTS 188 + E+V T + +F++A + L Sbjct: 206 GKLELVYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYM 264 Query: 189 ATKSNGLAISMPYWDERVEAM-AENYP------EIRWDKQHIDILCARFVMQPERFDVVV 241 +TK+ L + + + + Y I ++ + ID + A+ + F ++ Sbjct: 265 STKNTILKRYDGRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMA 323 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA- 295 N GD+ SD+ G++G+ S P+ + E HG+ Y G+ + Sbjct: 324 LKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFES-EAAHGTVTRHYREHQKGRETST 382 Query: 296 NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVI-AHGPKTPDMK---GN---- 345 NPIA+I+A L G D + A EV+ G T D+ G Sbjct: 383 NPIASIFAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKERE 442 Query: 346 --ATTPQVADAICKIIL 360 TT + A+ + + Sbjct: 443 AWVTTREYMAAVERRLK 459 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 198 bits (503), Expect = 3e-49, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 89/165 (53%), Gaps = 9/165 (5%) Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 +S + V MA+ +PEI+++++++D +C V P ++DV+V NL+GDILSD+ Sbjct: 112 RMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 171 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 G +G+ PS N+ +LFE VHG+APDI GK++ANP A + + MML + Sbjct: 172 GLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM---- 224 Query: 316 ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + I A E I G T D+ G A + + IC + Sbjct: 225 -ELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 268 Score = 51.1 bits (121), Expect = 7e-05, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 21/42 (50%), Gaps = 4/42 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW 45 T ++ IPGDGIG E+ ++ AA + +E ++ Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDV 84 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 111/301 (36%), Gaps = 19/301 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E ++++ +K + D Y+ VR FPG Sbjct: 93 DPLETDDFYNSVLRNRSAVHVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGF----- 147 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + D++ ++ +N G YS L +G VV SV T+ G ++ LR AF A Sbjct: 148 NCRFPDVNIRIIAQNNMGVYSDLEYSPVKG----VVEAISVSTQEGNEKYLRKAFATAVK 203 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDV 239 RK +T KS I+ + + ++Y + + +++ R + P+ FD Sbjct: 204 ANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHCLELELMNVEDCIGRLITHPQEFDC 263 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + +S+ + +++ + G + + + ++F+P+ + I +P Sbjct: 264 IFSSDRYATMIATMCSGICGGANLFSAVEIGDFH---AVFKPLQ-VKLSLTNYPILSPYG 319 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + D LG + + + + + G KT D G + V I + Sbjct: 320 IVNTIVDLFDHLGYT-----ECGDALWEQMLRTMESGIKTKDFGGEDSGEYVICNIINRL 374 Query: 360 L 360 Sbjct: 375 R 375 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 73/371 (19%), Positives = 137/371 (36%), Gaps = 34/371 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS----HHGKM 57 M ++++ G+G G E+ RV+Q+ A R+ +++F + Y S + Sbjct: 1 MSSIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADA 60 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 + ++ + + AV S+ L RE Q + + L P Sbjct: 61 VTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQAIKVEHFTLSPTSS- 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 +VR+ +G YS + T + V + + F++ RIL YA Sbjct: 120 -----------ILLVRDQAQGFYSGT---NSVNTSKDAVSRTAHFSKAIFARILSYALGR 165 Query: 178 AQSR--PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QP 234 A ++T K + + + + D + + Sbjct: 166 ANQLWGGTNSVTMVYKFHLF---DGLFHTWATEWERTF-GVNIRFVQGDTMNRDLLAFGV 221 Query: 235 ERFDVVVASNLFGDILSDLGPACTG----TIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 +++++ N + DI+ + G A + L+P+ S ++ HGSA D+ Sbjct: 222 SGHNLLISGNEYADIMQTILLDRFGLGAQESACAENVYLHPDVQGLSEYQTAHGSADDLL 281 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP ATI A A +L+ + + ++ A G TPD G ATT + Sbjct: 282 GKGIVNPTATIRAAAAVLEDQAGCSG----LKQRVDCVLGDLGARGIGTPDQGGTATTER 337 Query: 351 VADAICKIILR 361 +A + + + Sbjct: 338 FVEAFLQGLDQ 348 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 67/410 (16%), Positives = 120/410 (29%), Gaps = 61/410 (14%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M K M + D G E+ ++++ L E + + + Sbjct: 33 MTKIQMTTPLVEMD--GDEMTRIMWQMIKDELICPFVDLKTEYYDL-GLAHRDETDDQVT 89 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPG 114 D E R A P+ R D V P+ + G Sbjct: 90 VDSAEATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPI-VVRG 148 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ----------ESVFTR 164 + + + R Y R+ E+V FT Sbjct: 149 IDPCVKNWVRP---ITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTE 205 Query: 165 RG-----------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM---- 209 G ++ R F+ A + + + ATK + + + + Sbjct: 206 PGVVEGMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDAD 264 Query: 210 -AENYP--EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 A + I + ID AR + F + N GD++SD+ + G++ + S Sbjct: 265 YAARFEAAGIEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAMMTS 323 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKNIA------NPIATIWAGAMMLDFLGNGD--ERF 318 +P + +E HG+ Y K++A N +ATI+A L D Sbjct: 324 VLASPHGYW--EYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLADL 381 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKIIL 360 + + A I G T D+ +T A+ + + Sbjct: 382 AAFADALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDLK 431 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 72/377 (19%), Positives = 133/377 (35%), Gaps = 43/377 (11%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY--------SHH 54 +T+R+ G G G+E++ RV+Q A+++ F + Y+ + Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVRSSSTYHSYHTLTVSGEDKNL 63 Query: 55 GKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + D+ + + A G ++ L R+ Q + L G Sbjct: 64 ITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYLVRQHLQAAKVEHFSLGDG 123 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 +VR+ +G Y+ + + + + F++ DRI+R+A Sbjct: 124 NA------------LLMVRDEAQGFYAG---DNTYSADQLSITRTTSFSKPVFDRIIRFA 168 Query: 175 FELAQSR-----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 + A K +T A K + + + I +D D L Sbjct: 169 LDRAAENWGPENVPKKVTMAYKFHLF---DGVFQAWEPQWKAQF-GIDFDFIQPDTLNRS 224 Query: 230 FVMQ-PERFDVVVASNLFGDILSDLGPACTGTIG----IAPSANLNPERTFPSLFEPVHG 284 + + +++A N + D++ + G A + L P+ S ++ VHG Sbjct: 225 LMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETMYAENVYLRPDVNGLSEYQTVHG 284 Query: 285 SAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 SA I K + NP ATI A A +L G + AI+ ++ TPD Sbjct: 285 SADAIADKGLVNPFATIRAAAAILERHAGGKGIQ-----KLTEQAIQSLLQRKLTTPDQG 339 Query: 344 GNATTPQVADAICKIIL 360 G+ T + D + I Sbjct: 340 GSLKTEETVDHFLQAIA 356 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 187 bits (474), Expect = 7e-46, Method: Composition-based stats. Identities = 55/400 (13%), Positives = 115/400 (28%), Gaps = 71/400 (17%) Query: 8 AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLS 67 + D G E+ R+++ L + + + + E Sbjct: 86 PIVEMD--GDEMTRVIWRMIKDKLIFPYLDLDIKYFDL-GILNRDATDDKVTVESAEATL 142 Query: 68 RFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 +++ A PD R + V P+ +P + G Sbjct: 143 KYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCL-NIPRIVPGW 201 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV---------------------VIQESV 161 + + R +Y + + + ++ + ++ Sbjct: 202 KKP---ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKGPGVALAM 258 Query: 162 FTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN-----YPE 215 + R + LA + + L +TK+ L + + + + E + E Sbjct: 259 YNVDQSIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKQKFEE 317 Query: 216 --IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPER 273 I ++ + ID + A V + V N GD+ SD + A Sbjct: 318 HSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEAEAAHGTVT 369 Query: 274 TFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEE 331 LF+ ++ N IA+I+A L+ D E + + + E Sbjct: 370 RHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVHKLEGSCIE 421 Query: 332 VIAHGPKTPDMK----GN-------ATTPQVADAICKIIL 360 + G T D+ G T + DA+ + + Sbjct: 422 TVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLE 461 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 185 bits (469), Expect = 3e-45, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 126/377 (33%), Gaps = 44/377 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M +RI G G G E+ V++ A R+ + F + + Y + + D+ Sbjct: 4 MDPLRIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRIYHSY---NSLPLADE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + + G + FR + V L Sbjct: 61 SQNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAIS-------AQSLYAVRQQLEA 113 Query: 122 KQPGDID-----FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 + D V+R+ +G Y+ ++ + V + F + I+ ++ E Sbjct: 114 VKVECFDRGTSSLLVIRDQAQGFYTGTNK---LESDQDSVSRVCHFRKGVFQHIIAFSLE 170 Query: 177 LAQSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ + K++ K + + + I+ + D + Sbjct: 171 RAREKWGYDLGGIKSVFLVYKFHLF---DGLLLSWARDWTKEF-GIKVEFIQPDTMNRNL 226 Query: 231 VMQPERFDVVVASNLFGDILSDLG----PACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 + +++A N + DI+ + + + L P S ++ HGSA Sbjct: 227 IAFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSEYQTTHGSA 286 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI----AHGPKTPDM 342 DI GK I NP ATI A A +L+ G I A +++ + + TPD Sbjct: 287 DDITGKGIVNPSATIRAAAAILERFGGCVG--------IDAKVDDTLNILQKNKSGTPDQ 338 Query: 343 KGNATTPQVADAICKII 359 GN TT D + + Sbjct: 339 GGNLTTAAFVDVFLRTL 355 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 184 bits (467), Expect = 5e-45, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 111/293 (37%), Gaps = 19/293 (6%) Query: 69 FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDID 128 F+++ + LK + D YV + +R FPG C + D+D Sbjct: 110 FNSVLRNHAAVHVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKC-----RFPDVD 164 Query: 129 FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTS 188 V+ +N G YS L +G VV V T V + LR+AFE A R +T Sbjct: 165 IQVIAQNNIGNYSELEYAPVKG----VVEALRVVTHENVTKYLRHAFEAAIRAGRCRVTL 220 Query: 189 ATKSNGLAISMPYWDERVEAM-AENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFG 247 K+N ++ E E M AE+Y I+ + +D R + P FD + ++ + Sbjct: 221 IHKANEWPVTDGAMVEIAEKMHAEDYCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYA 280 Query: 248 DILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMM 307 L+ + G + + L ++F+P+ + + ++ +P + + Sbjct: 281 TFLATICSGVAGGANLFSAIELGDSH---AVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDL 336 Query: 308 LDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 L+ +G + + + G KT + G T V I + Sbjct: 337 LNHVGQES-----CAKSLWKGMLRTMTDGIKTVEFDGPDTGEYVICNIMNKLR 384 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 178 bits (452), Expect = 3e-43, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 108/286 (37%), Gaps = 26/286 (9%) Query: 81 DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEY 140 D P LLK R+E Y ++RP L Q + + + Sbjct: 35 DGAPATSRPERGLLKLRKEMGTYGSMRPCFFASD---SLVAPQGRGVPRHRLCHCARAHR 91 Query: 141 SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 L R G+ ++ V+R A L + R K L S +N LA S Sbjct: 92 RYLLWRAQTGSG--SAWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSRF 149 Query: 201 YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVASNLFGDILSDLGPACTG 259 + E + +P+++ + Q I+ V P + VVV S LFGDI+SD Sbjct: 150 WRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPD 209 Query: 260 TIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 +IG+ PSA+L + R ++EP+H + + A+ + + Sbjct: 210 SIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC----------- 256 Query: 316 ERFQQAHNGILAAIEE--VIAHGPKTPDMKGNATTPQVADAICKII 359 + + + ++ V +T ++ G A T ++ +A+ + Sbjct: 257 -PWPCFSDTLSTSLRRLWVPPWSLRTKELGGGANTKELGEAVINEV 301 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 175 bits (445), Expect = 2e-42, Method: Composition-based stats. Identities = 67/410 (16%), Positives = 114/410 (27%), Gaps = 71/410 (17%) Query: 16 GKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFG 75 G+E+ ++L F +S + SC+ D E R AI+ Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDISSWETFDLSCKARDDSDDATLIDAVEAGKRIGAIFKE 148 Query: 76 AVGWPD-----TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFY 130 P + + RR ++ R G+ + Sbjct: 149 PTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQ------VL 202 Query: 131 VVRENTEGEYSSLGGRVNEGT----------EHEVVIQESVFTRR------------GVD 168 R GEY + V EGT V+ + T + V Sbjct: 203 FERHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPYDNVR 262 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI------------ 216 + F+ TK +W + Y + Sbjct: 263 ELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFWATMKRVFDDTYKDEFLKAGLLDRSGG 321 Query: 217 RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP 276 D + + + + A N GD+L+D + G S + Sbjct: 322 ELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGVSDDGT 381 Query: 277 SL---FEPVHGSAPD-----IYGKNIA-NPIATIWA--GAMM----LDFLGNGDERFQQ- 320 +L FE HG+ D + GK + NP+ + A GAM L++ ++ + Sbjct: 382 TLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLEYDAKPNDVEAKR 441 Query: 321 -------AHNGILAAIEEVIAHGPKTPDMKGNA--TTPQVADAICKIILR 361 N + A+ +G T DM G TT + + R Sbjct: 442 MYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTGFTTEDFIAKVAWRLDR 491 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 175 bits (444), Expect = 2e-42, Method: Composition-based stats. Identities = 66/411 (16%), Positives = 119/411 (28%), Gaps = 65/411 (15%) Query: 6 RIAAIPGDGI-GKEVLPEGIRVLQAAAERWGFALS-FEQMEWASCEYYSHHGKMMPDDWH 63 +I A P + G+E+ + +++A + + + + + +++ D Sbjct: 7 KITAAPMVYVRGEEMTAYVMDLIRAKWIEPRVDTTAWREFDLRAKNRDDTEDQVLRD-VI 65 Query: 64 EQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 E AI+ P S RR ++ R GV Sbjct: 66 EAGKAVKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELG 125 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------EHEVVIQESVFTRR 165 + R GEY++ V +GT V + T Sbjct: 126 YKKPVFFE------RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDN 179 Query: 166 G------------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY 213 V + R+ F TK P+W + E Y Sbjct: 180 EAAVVTYHNPYDNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFWQIMKKVFDEEY 238 Query: 214 P-----------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 D + V + + A N GD+L+D + G Sbjct: 239 KSKFVDAGVMKSGDELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPG 298 Query: 263 IAPSANLNPERTFPSL--FEPVHGSAPD-----IYGKNIA-NPIATIWAGAMMLDFLGNG 314 S + + + FE HG+ D + G+ + NP+ + ++ + Sbjct: 299 FITSNLVGVDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADV 358 Query: 315 D----ERFQQAHNGILAAIEEVIAHGPKTPDMKGN--ATTPQVADAICKII 359 ER + A I ++ G T D+ G TT Q DA+ + + Sbjct: 359 HNVDKERTLAFTAKMRAVIHQLFREGKGTRDLSGPSGLTTEQFVDAVAERL 409 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 165 bits (417), Expect = 3e-39, Method: Composition-based stats. Identities = 64/435 (14%), Positives = 115/435 (26%), Gaps = 108/435 (24%) Query: 8 AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLS 67 + D G E+ R+++ L + + + E Sbjct: 66 PIVEMD--GDEMARIMWRMIKDKLIFPYLDLDIRYFDL-GILNRDATDDKVTVESAEATL 122 Query: 68 RFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 +++ A PD R + V P+ L VP + G Sbjct: 123 KYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPI-LCXNVPRIVPGW 181 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV---------------------IQESV 161 + + R +Y + V + ++V I ++ Sbjct: 182 KKP---ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKGPGIALAM 238 Query: 162 FTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDK 220 + R + LA + + L +TK+ L R++ Sbjct: 239 YNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG----------------RYEH 281 Query: 221 QHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA------------------------ 256 + ID + A + + V N GD+ SDL Sbjct: 282 RLIDDMVAYALKSDGGY-VWACKNYDGDVQSDLLAQGFLLHMRNERSDYPVXLHLVKSYP 340 Query: 257 ---------CTGTIGI---APSANLNPERTFPSLFEPVHGSAPDI---YGKNI---ANPI 298 G+ L+ + E HG+ Y K + N I Sbjct: 341 ILFVLSRIRFFGSYDFSIAISGKQLSSDGKTL-EAEAAHGTVTRHFRQYQKGLETSTNSI 399 Query: 299 ATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMK----GN------- 345 A+I+A L+ D ER + + AA E + G T D+ G Sbjct: 400 ASIFAWTRGLEHRAKLDKNERLLDFVHKLEAACIETVESGNMTKDLAILIHGPKASXEFY 459 Query: 346 ATTPQVADAICKIIL 360 T + D + + Sbjct: 460 LNTEEFIDTVAHNLE 474 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 164 bits (416), Expect = 4e-39, Method: Composition-based stats. Identities = 48/132 (36%), Positives = 67/132 (50%), Gaps = 8/132 (6%) Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P +FDV+V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGA--NGVAIFESVHGTAPDI 87 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATT 348 GK++ANP A + + MML +G I A + I T D+ GN Sbjct: 88 AGKDMANPTALLLSAVMMLRHMG-----LHGHAKKIETACFDTIRDKKVLTKDLGGNPKC 142 Query: 349 PQVADAICKIIL 360 + IC+ + Sbjct: 143 SEFTADICRRVQ 154 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 150 bits (378), Expect = 9e-35, Method: Composition-based stats. Identities = 46/206 (22%), Positives = 81/206 (39%), Gaps = 29/206 (14%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYS-HHGKM 57 I I GDGIG ++ P I+V+ AA ++ +S+ ++ Sbjct: 26 PNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTW 85 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P + + + + G + P + + R++ D YV LRPVR F GVP Sbjct: 86 LPQETLDAVKDYVVSIKGPLTTP----VGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPS 141 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVVIQ 158 P+ +PGD+D + REN+E Y+ + + + + I Sbjct: 142 PVK--KPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIG 199 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRK 184 ++ G R+ R A A++ K Sbjct: 200 VKPVSKEGTKRLARKALHSAEAAVVK 225 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 147 bits (372), Expect = 5e-34, Method: Composition-based stats. Identities = 47/186 (25%), Positives = 77/186 (41%), Gaps = 16/186 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG E+ +++ AA + FE E A + Y G+++P+ +E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFET-ENAGSDVYEKTGELIPESLYES 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R G + P + R+++D Y N R R PG+ + Sbjct: 58 VERNKIAIKGPITTPI----GKGFRSINVYLRKKYDLYTNFRSSRNLPGIET-----RYD 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +ID + RENTEG Y NE I T++G + +L+ + + + Sbjct: 109 NIDLAIFRENTEGIYIGEEKYENEEKT--SAIAVKRITKKGSEELLKVLLNMQRIMEFRK 166 Query: 186 LTSATK 191 L K Sbjct: 167 LQLFIK 172 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 147 bits (372), Expect = 5e-34, Method: Composition-based stats. Identities = 65/378 (17%), Positives = 126/378 (33%), Gaps = 53/378 (14%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE--RWGFALSFEQMEWASCEYYSHHGKMMP 59 + I I GDG G E+ I + +A E G + + E Y +GK +P Sbjct: 13 PDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGKYLP 72 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 + E + + + G + +I+ + +R + Y +++ + PG+ Sbjct: 73 RESIEDIRKTVFVMKGPLSS------NINGHDININIKRILNLYTDVKCITGLPGLSEGK 126 Query: 117 -----CPLAGKQP------GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR 165 P + D D +Y ++ G + ++ +R Sbjct: 127 EIFIFSPSIDEVYHFSYDSEDSDMLR-------QYLQQSFNISIGGDSDIF--LKGTSRY 177 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDI 225 + +I E++ K A G P W + + + + + Sbjct: 178 RIIKIASKIAEISSLYGIKRTLVADDYTGSHA--PLW--VYNTLNKMEMPVEIENLY--- 230 Query: 226 LCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGS 285 + RF++ + + ++ + A T A L F SLFE Sbjct: 231 NLYDEMTSESRFNIFIPDSRLSSLIIKIINART-----FFGAILGD---FISLFESQSRP 282 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP--DMK 343 + G ++A+P + + A +MML L F A + A+ V + G ++ Sbjct: 283 SFTEEGYDLADPTSFLLASSMMLRRL-----NFNDAALILRNALNSVYSDGILPASLNLN 337 Query: 344 GNATTPQVADAICKIILR 361 DAI K + R Sbjct: 338 NGLKCSDFIDAIVKRMKR 355 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 144 bits (364), Expect = 4e-33, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 63/174 (36%), Gaps = 18/174 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + PG G+G E+ + AA + +++ + ++ D Sbjct: 31 QFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHID-VDNAKPGQDLISADAL 85 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P L R+ Y N+RP PGV P Sbjct: 86 DSLRRNRFGLKGPMATPI----GKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---- 137 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 D+D VRENTEGEYS L V G VV V T V+ ++ F + Sbjct: 138 -DDVDVVTVRENTEGEYSGLEHVVYPG----VVESLKVITPERVNARVQVPFSI 186 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 135 bits (340), Expect = 2e-30, Method: Composition-based stats. Identities = 74/375 (19%), Positives = 127/375 (33%), Gaps = 46/375 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY-------SHHGKM 57 + G G G+EV RVL A R ++ + Y G Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAG 90 Query: 58 MPD---DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 +P+ E + ++ V ++ L R+ LR V+ Sbjct: 91 VPEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQ-----RLRAVK---- 141 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + +VR+ +G Y+ V + + F+R +++L YA Sbjct: 142 ----VDTLDADGARLLLVRDEAQGFYTG-----GNTHTPGHVSRTTEFSREITEQLLAYA 192 Query: 175 FELAQSR---PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 A+ + A K + L D V A I D + V Sbjct: 193 LRRAREEWPEGPARIVMAYKFHLL---DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLV 248 Query: 232 MQP-ERFDVVVASNLFGDILSDLGPACTGTI----GIAPSANLNPERTFPSLFEPVHGSA 286 P E V++A N + DI+ + G+ + +L+P ++ VHGSA Sbjct: 249 AHPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAVAELVEYQTVHGSA 308 Query: 287 PDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN 345 D+ G+++ NP+AT+ A A + ++G A V +TPD G Sbjct: 309 DDLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGV-----RTPDQGGK 363 Query: 346 ATTPQVADAICKIIL 360 +T V DA + + Sbjct: 364 HSTTGVVDAFIEELG 378 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 131 bits (329), Expect = 5e-29, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 103/263 (39%), Gaps = 10/263 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++A + GD V+ + +++++ A ++ + + +P+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDS-TAFEVTELPF-GVNGVLSFNEPLPNQTLR 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLAGK 122 +L +D I GA+ +S+ SL+ R+ + + + V++ PL + Sbjct: 60 ELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLKNQ 119 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 D DF +V+ + + + + +R V++++ FE A +R Sbjct: 120 IVRDTDFIIVQSAK----RANDHVDGNISVDDFAQDTITYEQREVEQVITAGFERAMNRK 175 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T T + + W E +A+ YP++ + + + + + QP DVVVA Sbjct: 176 RA-VTVVTPFDSF-YTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDVVVA 233 Query: 243 SNLFGDILSDLGPACTGTIGIAP 265 +L++ TG P Sbjct: 234 PKWVDQVLNEESQKITGLPETVP 256 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 130 bits (327), Expect = 7e-29, Method: Composition-based stats. Identities = 46/226 (20%), Positives = 89/226 (39%), Gaps = 18/226 (7%) Query: 138 GEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 G ++ L EG VV SV +++G D+ LRYAF+ A RK +T K+ I Sbjct: 2 GIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPI 57 Query: 198 SMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 S E + + +Y + + + ++ +R + +P FD + AS + LS + Sbjct: 58 SDGSLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSG 117 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN--PIATIWAGAMMLDFLGNG 314 G + + + ++F+P+ + N AN + + LG+ Sbjct: 118 VCGGANLFSAVEIGDHH---AVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGH- 170 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + + ++ + G +T + G T V I + Sbjct: 171 ----DKCADALWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLR 212 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 121 bits (303), Expect = 5e-26, Method: Composition-based stats. Identities = 66/125 (52%), Positives = 80/125 (64%), Gaps = 12/125 (9%) Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT- 300 N+FGDILSDLGPACTGTI +APS ++NPE FPSLFEPVHGS PDI+GK IANPI Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 301 --IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG----PKTPDMKGNATTPQVADA 354 GAM+LD LG + I + IE+V++ G P TPD+ G+A T + A Sbjct: 61 ARFGVGAMILDHLGY-----PETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKA 115 Query: 355 ICKII 359 I I Sbjct: 116 IAAAI 120 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 111 bits (278), Expect = 4e-23, Method: Composition-based stats. Identities = 52/227 (22%), Positives = 86/227 (37%), Gaps = 30/227 (13%) Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPY---WDERVEAMAENY-- 213 + + F A S K + K + + ++ +A ++ Sbjct: 357 LMSNDHEAIKDWVSQVFRDASS-KHKEVYFGLKREYMEYDEVFSTVINDVRRELAADHTS 415 Query: 214 -PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 P + + P R + A NL GDI SD+ A G++ A S + Sbjct: 416 PPAFMI--MRPSSQLIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASS--IIES 471 Query: 273 RTFPSLFEPVHGSAPDIYGKNIA--------NPIATIWAGAMMLDFLG--NGDERFQQAH 322 ++ LFE HG+A D+Y K + NP A I+A A L+ LG +E Sbjct: 472 KSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYS 531 Query: 323 NGILAAIEEVIAHGPKTPDMKGNATTPQ---------VADAICKIIL 360 + AA+++ + G T D+K TTP+ D+I K + Sbjct: 532 ARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRLG 578 Score = 56.5 bits (135), Expect = 1e-06, Method: Composition-based stats. Identities = 38/295 (12%), Positives = 78/295 (26%), Gaps = 56/295 (18%) Query: 1 MMKTMRI----AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK 56 M+ +++ + GD E+ + A+ +++ ++ + +G+ Sbjct: 1 MVNKIQVESPLVILHGD----EMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQ 56 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLW----------------GSLLKFRREF 100 ++ + E L ++ A + L R+ Sbjct: 57 VIF-EAIEALKKYGVGVKNAGMTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGI 115 Query: 101 DQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE--GEY--------------SSLG 144 + ++ F + DID + +N Y Sbjct: 116 GGNITREDIQ-FQNLRVRKPDWIDRDIDVDTM-DNGGIKDSYNELSSSTGVVKLLFVGKS 173 Query: 145 GRVNEGTEHEVV----IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 G E +V + V F+ A R K +A Sbjct: 174 GNPVELHRRDVKKGDPWLLATNDIADVKAWAHRFFQRAIDEKRDA-YLGLKDTVIAGYDG 232 Query: 201 YWDERVEAMAE-NYP------EIRWDKQHIDILCARFVMQPERFDVV-VASNLFG 247 +EA+ + Y I + + +D AR V P + V N G Sbjct: 233 VMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAARIVANPPERALWGVPDNTTG 287 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 111 bits (278), Expect = 4e-23, Method: Composition-based stats. Identities = 33/114 (28%), Positives = 48/114 (42%), Gaps = 3/114 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 98 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + DA+ GA+G H+ LL+ R + NLRP + P Sbjct: 99 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 107 bits (267), Expect = 8e-22, Method: Composition-based stats. Identities = 31/111 (27%), Positives = 46/111 (41%), Gaps = 9/111 (8%) Query: 96 FRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV 155 D Y ++ ++ P V D+D VV ENTEGEYS+L +G V Sbjct: 2 LHTTLDLYASVIHLKNLPNVET-----WHKDVDILVVWENTEGEYSNLEHESVKG----V 52 Query: 156 VIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 + T+ RI YAF+LAQ K + + K N + + + Sbjct: 53 TESLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 103 bits (257), Expect = 1e-20, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 60/164 (36%), Gaps = 14/164 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAA-ERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + ++ + GD IG E++ E ++ L ER F + A + + Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAGAS-LDKTNEPIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-- 115 D + DA+ G+VG P+ P ++ +L+ R+ D + N+RP R Sbjct: 60 DKVLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRFCASSLV 119 Query: 116 -PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 PL + N +Y++ ++ + Sbjct: 120 EQSPLKSDMVNGV-------NFGEQYAARSRSTGGCCTKDIGLA 156 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 103 bits (257), Expect = 1e-20, Method: Composition-based stats. Identities = 52/225 (23%), Positives = 87/225 (38%), Gaps = 26/225 (11%) Query: 160 SVFTRRGVDRILRYAFELAQSRPRKTLTSATKS---NGLAISMPYWDERVEAMAE-NYPE 215 R + ++ F A +K + K N + E + +A + P Sbjct: 358 MSNDRESIKDWVKQVFRDAALY-KKEVYFGLKREFVNYDEVYSSIILEIRKELAALDTPP 416 Query: 216 IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTF 275 + ++ + P R+ + A NL GDI SD+ A G++ A S + + T Sbjct: 417 PSFMIMRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTL 476 Query: 276 PSLFEPVHGSAPDIYGKNIA--------NPIATIWAGAMMLDFLGNGD--ERFQQAHNGI 325 LFE HG+A D+Y + + N A I+A A L+ L + + + Sbjct: 477 --LFEAPHGTAHDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNAPLAEYAEAL 534 Query: 326 LAAIEEVIAHGPKTPDMKGNATTPQ---------VADAICKIILR 361 AA+ E +A G T D+KG P+ DAI + + Sbjct: 535 KAALIETVAQGTITGDLKGKTLAPESETVVDMYGFLDAIESNLNK 579 Score = 57.3 bits (137), Expect = 9e-07, Method: Composition-based stats. Identities = 33/296 (11%), Positives = 80/296 (27%), Gaps = 58/296 (19%) Query: 1 MMKTMRI----AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK 56 M + +++ + GD E+ + + +++ ++ + + +G+ Sbjct: 1 MGERIKVEKPLVILHGD----EMAQIAFERILEQFVTSRLDIQLVEVDLSAEQRLTSNGQ 56 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVP----------------DHISLWGSLLKFRREF 100 ++ + E L A + D ++ R+ Sbjct: 57 VVL-EAIEALKDHGIGVKNAGMTVNRSQLDEMLAKYPQINEAQLDKLATKSPNGAIRKGI 115 Query: 101 DQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE---YS------SLGGRVNEGT 151 + + F + DI+ + + G YS + + G+ Sbjct: 116 GGNITREDI-EFRNLTSVRPDWVNRDIEVDTM--ESGGLDFSYSELSDATGVAKVMFVGS 172 Query: 152 EHEVV------------IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 + V + V F+ A R + K + Sbjct: 173 SGDPVELHRRTLKKGDPWMLATNDLDDVKAWAHRFFQRALDEKRD-IYLGLKDTVVPGYD 231 Query: 200 PYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERFDVV-VASNLFG 247 +E + +++ + ID AR V P + + V N+ G Sbjct: 232 GVMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNPPQRALWGVPDNVSG 287 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 100 bits (250), Expect = 7e-20, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 46/134 (34%), Gaps = 15/134 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+L + + + + FE + S + Sbjct: 50 RHTVTLIPGDGIGPELLNHVRELFRFSC----VPVDFEVVHVNSSSTSEDDIS----NAI 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + T+P + R D Y N+ + PGV + Sbjct: 102 MAIRRNGVALKGNIETNHTMPPN--HKSRNNLLRTSLDLYANVMHCQSLPGVQT-----R 154 Query: 124 PGDIDFYVVRENTE 137 +ID ++ E +E Sbjct: 155 HKNIDIIIILEKSE 168 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 99.6 bits (247), Expect = 2e-19, Method: Composition-based stats. Identities = 31/201 (15%), Positives = 60/201 (29%), Gaps = 34/201 (16%) Query: 86 HISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGG 145 R + V P+ L VP L+G + + R +Y + Sbjct: 28 KSMWRSPNGTIRNILNGTVFREPI-LCKNVPRILSGWKKP---ICIGRHAFGDQYRATDT 83 Query: 146 RVNEGTEHEVV--------------------IQESVFTRRGVDR-ILRYAFELAQSRPRK 184 +N + ++V + S++ R + +A S + Sbjct: 84 IINGPGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKW 142 Query: 185 TLTSATKSNGLAISMPYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERF 237 L +TK+ L + + + + I ++ + ID + A V + Sbjct: 143 PLYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGY 202 Query: 238 DVVVASNLFGDILSDLGPACT 258 V N GD+ SD Sbjct: 203 -VWACKNYDGDVQSDFLAQIF 222 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 90.4 bits (223), Expect = 9e-17, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 7/113 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I I GDGIG E++ E +VL ++G + +E + C G + D+ Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCS-IDATGVPLTDEAIAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDH------ISLWGSLLKFRREFDQYVNLRPVRLF 112 DA+ G++G + LLK R+ + + NLRP L+ Sbjct: 63 AKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 89.6 bits (221), Expect = 2e-16, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 110/356 (30%), Gaps = 80/356 (22%) Query: 2 MKTMRIAAIPGD--GIGKEVLPEGI---RVLQAA--------------AERWGFALSFEQ 42 M +IA IPGD GIG E++ + + V +AA A + G L + Sbjct: 6 MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65 Query: 43 MEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQ 102 + WA+ + + E + D S +L + D Sbjct: 66 IAWANLAEF----SGLRQLEMETIDVADV--------KVAEVTIQSGKSALRTLDQALDL 113 Query: 103 YV--NLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE------YSSLGGRVNEGTEHE 154 V + V P L N E E Y G +E + Sbjct: 114 AVAGIVDGVLFGPFNKAALTAAGL----------NAEDEHRYMARYLGFKGYHSEVNVLD 163 Query: 155 VVIQESV------------FTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPY 201 ++ V T GV + + A + + A + N A Sbjct: 164 DLMTTRVTSHIGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGK 223 Query: 202 W-DERVEAMAENYPEIRWDKQHID----ILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + E ++ +A E + H+ + D VV ++ D + Sbjct: 224 FGREEIDILAPVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIK 280 Query: 257 CTG---TIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLD 309 G + +A + + P HG+A DI G+++AN AT A ++L Sbjct: 281 LMGFDRGVTVAGGLPI-------PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLR 329 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 85.4 bits (210), Expect = 3e-15, Method: Composition-based stats. Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TP 340 VHGSAP G NP A + +G MML +L +A I +++V+A T Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNE-----HEAATRIEKGVDKVLAEAKHLTY 58 Query: 341 DMKGNATTPQVADAICKIIL 360 D G A+T + ADAI K + Sbjct: 59 DAGGTASTDEYADAIIKAMG 78 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 85.0 bits (209), Expect = 4e-15, Method: Composition-based stats. Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%) Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK 338 +EP GSAPDI GKNIANPIA I + AM++ + + + I +A+ + + G + Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRY----TMKLPIISDQIESAVIDTLKKGYR 66 Query: 339 TPDMKGNA----TTPQVADAICKIILR 361 T D+ + +T + D I I+ + Sbjct: 67 TLDIANDKEKCESTNDIGDIISYILKK 93 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 81.9 bits (201), Expect = 3e-14, Method: Composition-based stats. Identities = 44/87 (50%), Positives = 58/87 (66%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + RIA IPGDGIGKE +PE +RV AAA R+GFAL ++AS + + HGK+ PDD Sbjct: 1 MSSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDD 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHIS 88 + L +DA++FGAVG PDT + Sbjct: 61 RFDTLRGYDALFFGAVGRPDTGAADLG 87 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 81.1 bits (199), Expect = 5e-14, Method: Composition-based stats. Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 5/105 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T I + GDGIG E+ E ++VL +A C G + Sbjct: 360 MTTHTILVLRGDGIGLEITAEAVKVL-SAFSLKKRTFDLRSELIDGCS-IDTDGTPITKT 417 Query: 62 WHEQLSRFDAIYFGAVGWPDTVP---DHISLWGSLLKFRREFDQY 103 + DA+ F +VG P D G LL+ R+ +Q+ Sbjct: 418 VIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 78.8 bits (193), Expect = 2e-13, Method: Composition-based stats. Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDG+G EV+P + VL A G SFE++ G +P + Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGV-ALDLVGVPLPKET 97 Query: 63 HEQLSRFDAIYFGAVGWP 80 + + DA+ GAVGW Sbjct: 98 LIRAKQSDALLLGAVGWY 115 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 78.4 bits (192), Expect = 4e-13, Method: Composition-based stats. Identities = 32/129 (24%), Positives = 50/129 (38%), Gaps = 9/129 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + F ++ LK + D YV R FPG C Sbjct: 99 EAGQDDEYFHSVLRNRTAVHVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKC--- 155 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D ++ +N G ++ L EG VV SV +++G D+ LRYAF+ A Sbjct: 156 --RFPGVDIQLIGQNNMGIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAK 209 Query: 181 RPRKTLTSA 189 RK +T Sbjct: 210 AGRKRVTLI 218 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 76.5 bits (187), Expect = 1e-12, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 8/82 (9%) Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 GSAPDI GKNIANPIA I + AM++ + + + + I +++ + + G KT D+ Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRY----TMKLHKIADDIESSVIDALKKGYKTLDIA 57 Query: 344 G----NATTPQVADAICKIILR 361 + +T + D I I+ + Sbjct: 58 NVNETHISTSDMGDVISNILNK 79 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 75.7 bits (185), Expect = 2e-12, Method: Composition-based stats. Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 6/67 (8%) Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 IANP A + + ML + Q I AI EV+A G +T D+ G+++T + Sbjct: 155 IANPTAMLMCASKMLRHV-----NLQHYSESIRNAIREVLAAGKVRTRDLGGSSSTHEFT 209 Query: 353 DAICKII 359 DA+ K I Sbjct: 210 DAVIKAI 216 Score = 73.0 bits (178), Expect = 2e-11, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 42/103 (40%), Gaps = 8/103 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + IPGDG+ E++ VL+A G + FE + ++ ++ +D Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAI----GAPIDFETILFSEVQH---SSSAKVEDV 115 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVN 105 + ++R GA+ PD L +K R+ D N Sbjct: 116 IKSINRNRICLMGALMSPDVSYSGE-LQNLHMKLRKGLDLIAN 157 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 73.0 bits (178), Expect = 2e-11, Method: Composition-based stats. Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 2/79 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 KT +IA+IPGD IG EV+ I VL++ E + L F +++W Y GK MP D Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDW-GTARYKRTGKYMPAD 65 Query: 62 WHEQLSRFDAIYFGAVGWP 80 L F A FGAVG P Sbjct: 66 GLSTLKTFHAGIFGAVGAP 84 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 69.6 bits (169), Expect = 2e-10, Method: Composition-based stats. Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 3/79 (3%) Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP 340 P+HG APDI G IANP A + A +L G +E QQ N I +A E TP Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGY-EELAQQVENQIESAFYE--NRDQTTP 265 Query: 341 DMKGNATTPQVADAICKII 359 D G T + + + I Sbjct: 266 DQGGVLNTEKYMAMMVECI 284 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 67.7 bits (164), Expect = 6e-10, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 31/77 (40%), Gaps = 5/77 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ IPGDGIG E+ ++ +AA + ++ ++ + + +P E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA----NAPIEWDPVDVTPVKGDDGIFR-IPSKCIEL 81 Query: 66 LSRFDAIYFGAVGWPDT 82 + G + P+ Sbjct: 82 MRINKIGLKGPLATPNW 98 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 66.9 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 28/82 (34%), Gaps = 7/82 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + IPGDGIG E+ + + + +EQ + G+ + E Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYV----NAPIEWEQYNVSGMSSA---GEDLFKQAVE 61 Query: 65 QLSRFDAIYFGAVGWPDTVPDH 86 L R G + P + H Sbjct: 62 SLRRNRVGLKGILFTPISQSGH 83 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 66.5 bits (161), Expect = 1e-09, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 28/75 (37%), Gaps = 11/75 (14%) Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NA 346 NIANP + A ML ++G I A + + G T D+ Sbjct: 6 NIANPSGLLNAAVHMLIYIGQVGT-----AKLIYDAWLKTLEGGIHTADLYKEKRSKQKV 60 Query: 347 TTPQVADAICKIILR 361 T + A+A+ + + Sbjct: 61 GTKEFAEAVIDNLGK 75 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 66.5 bits (161), Expect = 1e-09, Method: Composition-based stats. Identities = 12/113 (10%), Positives = 25/113 (22%), Gaps = 10/113 (8%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++ + D G E+ ++ + + + Y + Sbjct: 42 KRIKVSQPVVEMD--GDEMTRIIWEFIKEKLILSNVDVELKYYDL-GLPYRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRP 108 D ++ A PD R V P Sbjct: 99 DSAIATQKYHVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTVFREP 151 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 65.3 bits (158), Expect = 3e-09, Method: Composition-based stats. Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 1/61 (1%) Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHG 336 +FEP HGSAPDI G+NIANPIA IW+GA ML G + A + V+ Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHRHPSAAGHGANKAVMIDA 60 Query: 337 P 337 Sbjct: 61 T 61 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 62.6 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 30/101 (29%), Gaps = 3/101 (2%) Query: 149 EGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 + + V +R A + + L A K N + + + Sbjct: 139 REIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAAE 198 Query: 209 MAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 E+ I W ID + A V P + ++ + F Sbjct: 199 TLESLAGAAGIAWRSLIIDHMAAELVRNPLDYRAILTHSSF 239 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.5 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 37/107 (34%), Gaps = 31/107 (28%) Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 +GP +G+ L E ++Y KNIANP AT+ A MMLD L Sbjct: 25 VGPELMAAVGVIECLKLGDGLFLQCCEE-----VAELYPKNIANPTATLLASCMMLDHL- 78 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 KT DM G AT +A+ + Sbjct: 79 -------------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 61.1 bits (147), Expect = 6e-08, Method: Composition-based stats. Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 10/93 (10%) Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 L G QP ++ +V EN EGEYS GR + E++I + + A+ Sbjct: 80 RSSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG---------LSKIAY 130 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 +L + P K + ATKSN + W+E Sbjct: 131 QLLRG-PEKHIAIATKSNAQRNGLVIWNEVAAE 162 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 56.1 bits (134), Expect = 2e-06, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 3/55 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG 55 M K I +PGDGIG E++ E ++VL+ A E++ + HG Sbjct: 8 MSKQ--ILILPGDGIGPEIMTEAVKVLELANEKYQLGFELT-HDVIGGAAIDKHG 59 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 55.7 bits (133), Expect = 3e-06, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 6/62 (9%) Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + A +MLD L + N I +AI + T D+ G TT +V +I +I Sbjct: 1 MLLASCLMLDHL-----KLHDYANMIRSAILTTMNETRLHTVDIGGQGTTSEVVQSIMRI 55 Query: 359 IL 360 I Sbjct: 56 IQ 57 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 51.1 bits (121), Expect = 5e-05, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 25/79 (31%), Gaps = 14/79 (17%) Query: 296 NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKG--------- 344 NPIA+I+A L D + N + E I G T D+ Sbjct: 6 NPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSAQ 65 Query: 345 ---NATTPQVADAICKIIL 360 T + + + + + Sbjct: 66 CSDYLNTFEFMEKLGENLK 84 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 50.7 bits (120), Expect = 7e-05, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 19/37 (51%) Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 R + +T K+N + ++ + +A+++P++ Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 50.7 bits (120), Expect = 9e-05, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 23/71 (32%), Gaps = 8/71 (11%) Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-------NYPE 215 T + + A + L +TK+ L + + + + E Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 216 IRWDKQHIDIL 226 I ++ + ID + Sbjct: 60 IWYEHRLIDDM 70 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 49.9 bits (118), Expect = 1e-04, Method: Composition-based stats. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCE 49 +I A+ GDGIG E++ G+ VL+A AE+ GF ++ + + Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGAD 47 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 46.1 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 24/71 (33%), Gaps = 4/71 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPGDGIG E+ +++ AA + S E Y + + Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQANVRPCVSIEGYKFNEMYLDTVCLNI 61 Query: 66 LSRFDAIYFGA 76 + A + Sbjct: 62 ETACFATIKCS 72 >UniRef50_D2H627 Putative uncharacterized protein n=1 Tax=Ailuropoda melanoleuca RepID=D2H627_AILME Length = 185 Score = 45.7 bits (107), Expect = 0.003, Method: Composition-based stats. Identities = 10/82 (12%), Positives = 20/82 (24%), Gaps = 7/82 (8%) Query: 46 ASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREF 100 + E + + D E + +++A A PD R Sbjct: 104 SEIENHDATNDQVTKDAAEAIKKYNAGVKCAAITPDEKRVEEFKLKQMWKSPNGTIRNIL 163 Query: 101 DQYVNLRP--VRLFPGVPCPLA 120 V + P + + Sbjct: 164 GGTVFREAIICKNIPRLASDVR 185 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 45.7 bits (107), Expect = 0.003, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 46/174 (26%), Gaps = 18/174 (10%) Query: 188 SATKSNGLAISMPYWDERVEAMAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASN 244 K N + + + + E I + ID + A P+ + ++ Sbjct: 1 MTHKGNSIKYTDGLFAVVAKQELEKLIGDSGIIQESLIIDHMAAELTRNPQDYRAILTHG 60 Query: 245 ---------LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 L G + +D TIG A + H AP+ Sbjct: 61 AFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDP---ARHTRAPEAEAAGRL 116 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 + + AG+++ D L G T + A T Sbjct: 117 RSV--LLAGSLLADHLDQGVAAAGIRAAADALDAPATADGHAGTAGLAACARTA 168 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 45.7 bits (107), Expect = 0.003, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 30/83 (36%), Gaps = 14/83 (16%) Query: 292 KNIANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDM----KGN 345 K NPIA+I+A + L+ D R + + A E + G + D+ G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 346 --------ATTPQVADAICKIIL 360 T+ + D + + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERLK 85 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 44.5 bits (104), Expect = 0.006, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 25/52 (48%), Gaps = 6/52 (11%) Query: 310 FLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G G++ N I A+E+V+ +T + G+ATT + A + + Sbjct: 39 HVGEGEK-----ANAIRNAVEKVLNIDNVRTGGLGGSATTKEFTAATERRLA 85 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 43.8 bits (102), Expect = 0.010, Method: Composition-based stats. Identities = 14/28 (50%), Positives = 21/28 (75%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAER 33 +I A+ GDGIG E++ G+ VL+A AE+ Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEK 31 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 43.4 bits (101), Expect = 0.012, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 18/45 (40%), Gaps = 4/45 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA 46 ++ PGDGIG E+ +V AA + +++ Sbjct: 41 STPIKATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVG 81 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 43.4 bits (101), Expect = 0.014, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 35/89 (39%), Gaps = 9/89 (10%) Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV 332 +LFEP+ S + K NPI I++ A++L G Q+ I A+ Sbjct: 2 GIGINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLSRFG-----LQEEAGAIQMAVNSA 54 Query: 333 IAHG-PKTPD-MKGNATTPQVADAICKII 359 G T D + + Q+ D + I Sbjct: 55 GERGMYTTLDTLPKDINCDQLGDYLAAAI 83 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 42.2 bits (98), Expect = 0.031, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 13/26 (50%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQA 29 + IPGDGIG E++ V + Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10 Tax=Proteobacteria RepID=PDXA2_PSEAE Length = 337 Score = 41.5 bits (96), Expect = 0.045, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 31/92 (33%), Gaps = 12/92 (13%) Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTG-TIGIAPSANLNPERTFPSLFEP 281 D + + FD VV ++ D + G + G+ + P Sbjct: 252 ADTIFLKVQGDARAFDAVVT--MYHD-QGQIAIKLMGFSRGVTVQG-----GLPIPIATP 303 Query: 282 VHGSAPDIYGKNIANPIATIWA---GAMMLDF 310 HG+A DI G+ A+ AT A M Sbjct: 304 AHGTAFDIAGQGRADVGATRQAFEIACRMGRH 335 >UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Lactobacillus paracasei subsp. paracasei 8700:2 RepID=C5F751_LACPA Length = 326 Score = 41.1 bits (95), Expect = 0.066, Method: Composition-based stats. Identities = 62/342 (18%), Positives = 103/342 (30%), Gaps = 56/342 (16%) Query: 4 TMRIAAIPGD--GIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 T I GD GIG E+ L+A + E + + S E +++ ++ Sbjct: 2 THFIGITIGDPSGIGPEIS------LKALMKNEQ--YLNESIIFGSKEIMTYYADLLKIK 53 Query: 62 W-HEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLR-- 107 + D G + P IS + + D + + Sbjct: 54 TPLNFIKDVDQFEAGKINIYNVMDIPLDKIPIGEVSPISGDAAFQFLKVAIDLAMKKKIG 113 Query: 108 PVRLFP-GVPCPLAGKQPGDIDFYVVRENTE-GEYSSLGGR-------VNEGTEHEVVIQ 158 PV P G D + E T +Y+ + V+ Sbjct: 114 PVVTAPLNKDALHKGGHNFDGHTEIFAEFTGTKKYTMMLWSKKLAVVHVSTHVPLRKACD 173 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPYWDERVEAMAENYPEI- 216 T+ V+ + A + A N A + + E + E P + Sbjct: 174 L--VTKARVEECIDLANSAIKRLGISKPRIAVAGLNPHAGEDGLFGD--EEIKEINPAVK 229 Query: 217 RWDKQHIDIL------CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN-- 268 Q ID+ +FD+VVA + D G + N Sbjct: 230 EKQSQGIDVQGALPPDTVFLKASQGKFDIVVA------MYHDQGHIPMKLLAFDEGVNVT 283 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDF 310 L S+ HG+A DI GK IAN + + + A+ + F Sbjct: 284 LGLPIIRTSV---DHGTAFDIAGKGIANESSMLASIALAIKF 322 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 430 e-119 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 424 e-117 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 408 e-112 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 405 e-111 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 402 e-111 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 398 e-109 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 396 e-109 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 395 e-108 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 394 e-108 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 393 e-108 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 393 e-108 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 393 e-108 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 386 e-106 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 386 e-106 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 386 e-106 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 385 e-105 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 385 e-105 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 385 e-105 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 385 e-105 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 385 e-105 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 383 e-105 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 382 e-104 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 380 e-104 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 378 e-103 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 378 e-103 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 377 e-103 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 376 e-103 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 376 e-102 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 375 e-102 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 375 e-102 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 374 e-102 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 374 e-102 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 372 e-101 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 372 e-101 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 372 e-101 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 371 e-101 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 370 e-101 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 369 e-101 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 369 e-101 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 369 e-101 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 368 e-100 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 368 e-100 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 368 e-100 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 367 e-100 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 366 e-100 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 366 e-100 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 366 e-100 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 365 2e-99 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 365 2e-99 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 363 5e-99 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 359 8e-98 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 359 9e-98 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 359 1e-97 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 359 1e-97 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 358 1e-97 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 358 2e-97 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 357 3e-97 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 357 4e-97 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 357 4e-97 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 356 6e-97 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 356 8e-97 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 352 9e-96 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 352 1e-95 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 352 1e-95 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 352 1e-95 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 352 1e-95 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 351 2e-95 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 351 2e-95 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 351 3e-95 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 351 3e-95 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 348 2e-94 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 348 2e-94 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 347 3e-94 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 347 5e-94 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 345 2e-93 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 345 2e-93 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 345 2e-93 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 344 2e-93 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 344 2e-93 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 344 4e-93 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 343 4e-93 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 343 4e-93 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 341 2e-92 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 341 3e-92 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 341 3e-92 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 340 5e-92 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 340 5e-92 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 339 8e-92 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 339 1e-91 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 337 4e-91 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 337 5e-91 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 336 5e-91 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 336 6e-91 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 336 8e-91 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 335 2e-90 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 335 2e-90 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 332 1e-89 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 331 2e-89 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 331 3e-89 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 331 3e-89 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 330 4e-89 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 330 5e-89 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 329 7e-89 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 329 1e-88 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 328 2e-88 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 326 6e-88 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 325 1e-87 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 325 2e-87 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 324 2e-87 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 324 4e-87 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 323 5e-87 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 322 1e-86 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 322 1e-86 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 321 2e-86 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 321 2e-86 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 321 3e-86 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 320 6e-86 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 319 7e-86 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 319 1e-85 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 318 2e-85 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 318 3e-85 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 314 3e-84 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 313 8e-84 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 311 2e-83 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 311 2e-83 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 309 7e-83 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 309 1e-82 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 306 6e-82 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 306 7e-82 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 303 5e-81 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 301 2e-80 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 300 4e-80 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 297 3e-79 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 297 3e-79 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 294 4e-78 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 292 9e-78 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 292 1e-77 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 291 2e-77 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 291 2e-77 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 291 3e-77 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 279 9e-74 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 279 1e-73 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 279 1e-73 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 277 5e-73 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 274 4e-72 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 273 5e-72 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 272 1e-71 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 271 4e-71 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 270 5e-71 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 269 8e-71 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 265 2e-69 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 261 4e-68 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 259 1e-67 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 258 2e-67 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 257 3e-67 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 255 2e-66 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 252 2e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 248 3e-64 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 246 8e-64 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 237 5e-61 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 235 2e-60 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 234 5e-60 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 230 5e-59 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 230 5e-59 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 227 4e-58 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 226 1e-57 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 222 2e-56 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 222 2e-56 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 212 1e-53 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 212 2e-53 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 212 2e-53 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 205 2e-51 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 199 1e-49 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 196 9e-49 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 196 1e-48 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 196 1e-48 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 194 4e-48 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 189 1e-46 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 188 2e-46 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 188 4e-46 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 187 5e-46 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 184 4e-45 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 180 1e-43 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 173 7e-42 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 165 2e-39 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 157 6e-37 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 154 4e-36 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 148 3e-34 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 143 7e-33 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 137 5e-31 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 129 1e-28 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 129 2e-28 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 121 3e-26 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 116 1e-24 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 113 1e-23 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 113 1e-23 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 107 7e-22 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 107 8e-22 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 105 4e-21 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 99 2e-19 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 96 2e-18 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 90 8e-17 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 85 3e-15 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 85 3e-15 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 85 5e-15 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 82 4e-14 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 79 2e-13 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 77 1e-12 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 77 1e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 76 2e-12 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 75 3e-12 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 70 1e-10 UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 68 4e-10 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 68 7e-10 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 67 7e-10 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 67 9e-10 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 66 2e-09 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 63 1e-08 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 61 5e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 61 6e-08 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 61 7e-08 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 56 2e-06 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 55 5e-06 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 53 1e-05 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 53 1e-05 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 52 4e-05 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 51 6e-05 Sequences not found previously or not previously below threshold: UniRef50_D2H627 Putative uncharacterized protein n=1 Tax=Ailurop... 48 5e-04 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 47 0.001 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 46 0.002 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 46 0.003 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 45 0.003 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 44 0.007 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 44 0.008 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 43 0.022 UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis R... 42 0.029 UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n... 42 0.037 UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot... 41 0.053 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 430 bits (1107), Expect = e-119, Method: Composition-based stats. Identities = 278/363 (76%), Positives = 311/363 (85%), Gaps = 2/363 (0%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIAAIPGDGIG EVLPEGIRVL+AAA + G AL F+ EWASC+YY HGKMMP Sbjct: 1 MPAHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMP 60 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW EQL ++DAIYFGAV WPD VPDHISLWGSLLKFRREFDQYVN+RPVRLFPGVPC L Sbjct: 61 DDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCAL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 A ++ GDIDF VVRENTEGEYSSLGG + E TE+E+VIQES+FTRRGVDRIL+YAF+LA+ Sbjct: 121 ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAE 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD- 238 R RK +TSATKSNG+AISMPYWD+R EAMA +YP + WDKQHIDILCARFV+QPERFD Sbjct: 181 KRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDV 240 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVVASNLFGDILSDLGPAC GTIGIAPSANLNPER FPSLFEPVHGSAPDI+GKNIANPI Sbjct: 241 VVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPI 300 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A IW+GA+ML+FLG GDER+Q+AH+ +L AIE VIA G TPDM G +T QV AI Sbjct: 301 AMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDMGGTLSTQQVGAAISDT 360 Query: 359 ILR 361 + R Sbjct: 361 LAR 363 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 424 bits (1091), Expect = e-117, Method: Composition-based stats. Identities = 254/360 (70%), Positives = 298/360 (82%), Gaps = 2/360 (0%) Query: 1 MMKT-MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIA IPGDGIG EV+PEG+R L A + R+G ++E +EWASC+YY+ HG+MMP Sbjct: 36 MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP 95 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW QLS DA+ FGAVGWP+TVPDHISLWGSL+KFRREFDQYVNLRP RLF GVPCPL Sbjct: 96 DDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPL 155 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 AG++ GDIDF +VRENTEGEYS++GG + EGTE E V+Q++VFTR G +R+L++AFELAQ Sbjct: 156 AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQ 215 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R K LT ATKSNG+AISMP+WD R MA YP++ WDKQHIDILCARFVMQP+RFDV Sbjct: 216 RRA-KRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDV 274 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 VVASNLFGDILSDLGPACTGTIGIAPSANLNPER FPSLFEPVHGSAPDI GK+IANPIA Sbjct: 275 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIA 334 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 IW+ AMM+DFLG G ++AH+ I+AAIE V+ HGP+T DM G A+T +V DAI + Sbjct: 335 MIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHL 394 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 408 bits (1049), Expect = e-112, Method: Composition-based stats. Identities = 223/359 (62%), Positives = 268/359 (74%), Gaps = 9/359 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +IA IPGDGIG EV+PEGIRVL+AA+ ++GF L+F +W SC Y G MMP D Sbjct: 5 QQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDW-SCARYHSQGSMMPSDG 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L DAI+ GAVG+P VPDH+SLW L+ RREFDQYVNLRPVRL PGVPCPLA K Sbjct: 64 IERLRDSDAIFLGAVGFP-GVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANK 122 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +PGDIDF++VRENTEGEYS +GGR+ GTEHE V QE++FTRRG DRI+RYAF+LA+ Sbjct: 123 KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFDLAKKLG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +TSATKSNG+ SMP+WDER A+ YP+IR D+ HIDIL ARF M PERFDVVV Sbjct: 183 RNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPERFDVVVG 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGP TGTI +APSAN+NPER +PS+FEPVHGSAPDI G+ IANPI IW Sbjct: 243 SNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIW 302 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA--HGPKTPDMKGNATTPQVADAICKII 359 +GAMML+ LG +A I+ AIE V+ TPD+ G A+T Q+ I + + Sbjct: 303 SGAMMLEHLGQ-----PEAAAAIMQAIETVLTHPDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 405 bits (1041), Expect = e-111, Method: Composition-based stats. Identities = 181/360 (50%), Positives = 243/360 (67%), Gaps = 8/360 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ +IAAIP DGIG EV+ G++VL+A +R G F++ E +W +YY +G MMP Sbjct: 1 MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDW-GSDYYKKNGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL +FDAI+FGAVG PD VPDHI+LWG L + FDQY N+RP ++ PG+ PL Sbjct: 60 DGLEQLKKFDAIFFGAVGAPD-VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLR 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 PGD+D+ +VREN+EGEYS GGR ++G EV + ++FTR GV RI+RYAF+LAQ+ Sbjct: 119 NCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQA 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN M WDE +++ +P++ WDK +D + R ++P+ D + Sbjct: 179 RPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++G+AP+AN++PER FPS+FEP+HGSA DI GK IANP+AT Sbjct: 239 VATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVAT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W A ML+ LG D A +++A+E V G TPD+ G A T QV DA+C+ I Sbjct: 299 FWTAAQMLEHLGEKD-----AATRLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAIA 353 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 402 bits (1034), Expect = e-111, Method: Composition-based stats. Identities = 173/359 (48%), Positives = 231/359 (64%), Gaps = 9/359 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 T RIA+IPGDGIG EV+ I+V++ A+ G F + F + W YY HG+ + +D Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPW-GTAYYKEHGRYVSEDC 104 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L +FDA FGAVG PD VPDHISLWG LL R Y N+RPVR FPG CPL Sbjct: 105 LDTLRKFDAGLFGAVGAPD-VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPL-NT 162 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ +VREN+EGEYS GGR + G E + ++FTR G++RI+R+AFE+AQSRP Sbjct: 163 ATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEVAQSRP 222 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK LT TKSN + M WD+ +A+++P++ WDK +D + R V +P+ D +V Sbjct: 223 RKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSIDTIVG 282 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NL DILSDL A G+IG+APS+NL+P R PS+FEPVHGSA DI GK +ANP+AT W Sbjct: 283 TNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFW 342 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + A ML +LG ++A ++ +E+V A G TPD+ G + T V DA+ K I R Sbjct: 343 SAAEMLSWLGE-----KEAAKQLMDCVEKVCAAGILTPDLGGTSNTQGVVDAVKKEIER 396 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 398 bits (1024), Expect = e-109, Method: Composition-based stats. Identities = 126/357 (35%), Positives = 181/357 (50%), Gaps = 27/357 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T +I IPGDGIG EV +RVL+A G +E A E Y + + +P + + Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA----TGLKFEWESF-AAGAEAYEKYKEYIPKELN 56 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G V P ++ R+ F+ Y N+RP+R PGV + Sbjct: 57 ESIERTRIGLKGPVTTPI----GGGFSSINVELRKRFELYANVRPIRNLPGV-----HTR 107 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D VVRENTEG YS + V G VV + T + RI ++AF A+ R Sbjct: 108 YPGVDLVVVRENTEGLYSGIEHEVVPG----VVESLKIITEKASTRISKFAFNYARKMGR 163 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K + S K+N + +S + +++ YPEI + + +D C + VM P ++D+++ Sbjct: 164 KKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLE 223 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SDL G +G+AP AN+ S+FE VHGSAPDI GKNIANP A I + Sbjct: 224 NLYGDIVSDLCAGLVGGLGLAPGANIGERA---SIFEAVHGSAPDIAGKNIANPTAVIRS 280 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 G +ML L D A N + AA+ V G T DM G +T + AD + + I Sbjct: 281 GILMLRHLDEQD-----AANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 396 bits (1017), Expect = e-109, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 183/355 (51%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIGKEV+ + +L+ + + A E +GK +PD+ E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKL----DLPFEYSYYD-AGDEALEKYGKALPDETLEA 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA+ FGA G + +++ RRE + N+RP + G+ C Sbjct: 58 CRKSDAVLFGAAG--------ETAADVIVRLRRELGTFANVRPAKAIEGIECLY-----P 104 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D VVRENTE Y +V V TR +RI RYAFELA+ RK Sbjct: 105 GLDIVVVRENTECLYMGFEFGFG-----DVTEAIRVITREASERIARYAFELAKREGRKK 159 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A++YPEI+++ +ID C VM P RFDV+V +N+ Sbjct: 160 VTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDI+SDL G +G+APSAN+ ++FEPVHG+A DI GK IANP A I Sbjct: 220 FGDIVSDLAAGLVGGLGLAPSANVGER---TAIFEPVHGAAFDIAGKGIANPTAMILTAC 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML G +E + A+E+ I G KTPD+ GN T + A+ + ++ Sbjct: 277 MMLRHFGYVEE-----AKKVEEAVEKTIKEGKKTPDLGGNLKTMEFANEVASLLD 326 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 395 bits (1015), Expect = e-108, Method: Composition-based stats. Identities = 179/362 (49%), Positives = 229/362 (63%), Gaps = 9/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MKT RIA IPGDGIGKEV+P G + +Q AE G F F+ +W +YY HG MMP Sbjct: 1 MKTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGG-DYYRRHGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E L DAI FG+ G PD DHI+LWG LK + DQY N+RP RL PG+ PL Sbjct: 60 DGLEPLRDKDAILFGSAGDPDIA-DHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLK 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D+ +VREN+EGEYS +GGRV++G E S+ TR GV+RILRYAF LAQS Sbjct: 119 RCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFRLAQS 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN +M WDE ++ +P++RWDK+ +D AR V +P D + Sbjct: 179 RPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPASLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++GIAP+ N++PER PS+FEP+HGSA DI GK +ANPI T Sbjct: 239 VATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 W+ M+L+ LG QA ++ A+E V A T D+ G ATT QV A+C+ + Sbjct: 299 FWSVVMLLEHLGE-----HQAAARMMRAVESVTADQALHTRDLGGTATTEQVTQAVCQHL 353 Query: 360 LR 361 + Sbjct: 354 RQ 355 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 394 bits (1012), Expect = e-108, Method: Composition-based stats. Identities = 104/357 (29%), Positives = 166/357 (46%), Gaps = 27/357 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +A IPGDGIG E+ + + A + +E ++ + MP + Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTPRPTEDGRFR-MPQSSLDI 2032 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+EF+ Y N+RP + G P Sbjct: 2033 IRKHGIGLKGPLATPI----GKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYKN---- 2084 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D VRENTEGEYS + + +G VV + T R+ R+AF+ A+ R++ Sbjct: 2085 -VDLVTVRENTEGEYSGIEHVIVDG----VVQSIKLITEEASRRVARFAFQYAKDNGRRS 2139 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + A ++ EI + +D +C V P RFDV+V NL Sbjct: 2140 VTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNL 2199 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI G++ ANP A +++ Sbjct: 2200 YGDILSDLAAGLIGGLGVTPSGNIGETG---AIFESVHGTAPDIAGQDRANPTALLFSAI 2256 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 MML ++ + + I +A+ I T D+ G +T Q IC+ I + Sbjct: 2257 MMLRYM-----NLNKHADLIESAVLATIREAKYLTADLGGRSTCSQYTKEICRQIEQ 2308 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 108/361 (29%), Positives = 181/361 (50%), Gaps = 24/361 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M I+ + GDGIG E+ + +L+A + + +L +++E A + GK +PD Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLE-AGDAVLKNTGKALPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + DA VG S ++ RR D Y N+RP + +P +P Sbjct: 60 ETFEAIKNSDACLKAPVG--------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D+D +VRENTE Y+ + + + + + + RI YAF +A Sbjct: 110 ---RDDVDLVIVRENTEDLYTGEEFDIG-----DAAVAFRIISEKASKRIANYAFTIASK 161 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R K +T KSN + + + +A ++P++++++ ++D + QP+ FDV+ Sbjct: 162 RKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQLFDVI 221 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDILSD G +G+AP+AN+ LFEPVHG+A DI GK IANP + Sbjct: 222 VTTNLFGDILSDESAQVVGGLGMAPAANIGDN---FGLFEPVHGAAFDIAGKQIANPTSF 278 Query: 301 IWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 I + MMLD+LG + D++ + + + +++ + KT D+ G+ TT + I Sbjct: 279 ILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGDKTTMEFTKEIISR 338 Query: 359 I 359 + Sbjct: 339 L 339 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 393 bits (1009), Expect = e-108, Method: Composition-based stats. Identities = 175/362 (48%), Positives = 241/362 (66%), Gaps = 10/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ RIA +PGDGIG EV+ E ++VL+ ++ F + W S EYY HG+MMP+ Sbjct: 1 MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNS-EYYLQHGRMMPE 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + L +DAI FGA+G P VPD IS+W ++ R+ F QYVNLRPV+ G+P Sbjct: 60 NGLDILKNYDAILFGAIGDPR-VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFI 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ I+F +VREN EGEYS+ GGR+ +GT+ E+ +Q ++ TR+G +RI RYAF+ A+ Sbjct: 119 HQERP-INFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKK 177 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + +ATKSN + SM WDE +E +A YP+I+ +K +ID L A FV +P+ V+ Sbjct: 178 HGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDLG A G +GI+PSAN+NPE FPS+FEPVHGSAPDI GK ANPIA Sbjct: 238 VASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 IW+ A+ML LG D + IL AIE+V HG T D+ GN+TT ++ + I + I Sbjct: 298 IWSAALMLQSLGREDL-----ASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQI 352 Query: 360 LR 361 ++ Sbjct: 353 VK 354 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 393 bits (1009), Expect = e-108, Method: Composition-based stats. Identities = 109/359 (30%), Positives = 168/359 (46%), Gaps = 32/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ IPGDGIG E+ RV A + +E + + + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKA----PIEWETVVV-------DANTGISKE 69 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E +S+ G + P L R+ F+ Y N+RP PG Sbjct: 70 VIESISKNKIGLKGPISTPI----GTGHQSLNLGLRKTFNLYANIRPCLSIPGHKT---- 121 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + +++ VVRENTEGEYS + + +G V + T+ RI YAF+ A + Sbjct: 122 -RYNNVNTVVVRENTEGEYSGIENQPVKG----VAQSIKIITKEASTRIAHYAFQYALAN 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T K+N + S + + ++ YP I++++ ID C + V+ P + DV+V Sbjct: 177 GRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQMDVMV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDI+SDL G +G+ PS N+ + ++FE VHG+APDI GKN ANP A I Sbjct: 237 LPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGS--AIFEAVHGTAPDIAGKNKANPTALI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + MML LG+ E + I A+ + G T D+ GN++ + D + K I Sbjct: 295 LSSIMMLRHLGHFHE-----ASIIENAVLNTLTEGKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 386 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 187/361 (51%), Positives = 243/361 (67%), Gaps = 11/361 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IAAIPGDG+GKEV+ +VL AAE G + SF W SC+YY HGKMMP+ Sbjct: 3 MKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPW-SCDYYLEHGKMMPE 61 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L++F+A++ GAVG P VPDHISLWG LLK RRE + +N+RP + G+ PL Sbjct: 62 DGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLL 121 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 P D DF V+REN+EGEYS +GGR++ G + E+ IQ +VFTR+ +R++R+AFELA+ Sbjct: 122 H--PNDFDFVVIRENSEGEYSEVGGRIHRG-DDEIAIQNAVFTRKATERVMRFAFELAKK 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R +TSATKSNG+ +MP+WDE + A +Y I QHID L A FV +PE FDV+ Sbjct: 179 R-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDIL+D+ + G+IGIAPSAN+NP +PS+FEPVHGSAPDI G+ +ANPI Sbjct: 238 VASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 IW +MLD G + IL +E+V A G KT D+ G +TT +V D IC + Sbjct: 298 IWTAKLMLDHFGEEEL-----GAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEICSRLR 352 Query: 361 R 361 + Sbjct: 353 K 353 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 386 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 132/367 (35%), Positives = 190/367 (51%), Gaps = 18/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M++ +A + GDGIG EV+ E ++VL E++GF L+F + H G +P + Sbjct: 1 MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGG-AAIDHCGYPLPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + DAI FG+VG P PD G+LL R+ F + NLRP L+ G+ Sbjct: 60 TLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKF 119 Query: 117 CPLAGKQP-GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 CPL D VVRE T G Y V+ + ++RI R AF Sbjct: 120 CPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAF 179 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A R K +TS K+N L S+ W E V MA++YPE+ + +ID + + PE Sbjct: 180 EAAMKRN-KKVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPE 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDV++ SN+FGDI+SD TG++G+ PSA+LN L+EP GSAPDI GK IA Sbjct: 238 SFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNE--AGFGLYEPAGGSAPDIAGKGIA 295 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG---NATTPQVA 352 NPIA I + AMML + +A + I +A+++V+A G +T D+ +T ++ Sbjct: 296 NPIAQILSAAMMLRY----SFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMG 351 Query: 353 DAICKII 359 I + I Sbjct: 352 TLITQAI 358 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 386 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 107/356 (30%), Positives = 170/356 (47%), Gaps = 26/356 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPGDGIG E+ +++ AA + +E+ + + M+P + E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQWEERNVTAIQGP-GGKWMIPSEAKES 87 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+ FD Y N+RP G P Sbjct: 88 MDKNKMGLKGPLKTPIAA----GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT----- 138 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D++ +RENTEGEYS + + +G VV + T RI +AFE A++ R Sbjct: 139 DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLITEGASKRIAEFAFEYARNNHRSN 194 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + ++ +AE+ +I++++ ++D +C V P +FDV+V NL Sbjct: 195 VTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNL 254 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI GK++ANP A + + Sbjct: 255 YGDILSDLCAGLIGGLGVTPSGNIGA--NGVAIFESVHGTAPDIAGKDMANPTALLLSAV 312 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 MML +G I AA I G T D+ GNA + IC+ + Sbjct: 313 MMLRHMG-----LFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVK 363 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 166/361 (45%), Positives = 220/361 (60%), Gaps = 11/361 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +IA IPGDG G E + EG++VL AAA + GFAL ++W EYY G+++P Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGG-EYYLRTGEVLPP 71 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL R+DAIY GA+G P+ P + G LL+ R E DQY+NLRPV+L+PGV P+A Sbjct: 72 DAVEQLKRYDAIYLGAIGHPEVRPGIL-EKGILLRLRFELDQYINLRPVKLYPGVETPIA 130 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 GK P DIDF VVRENTEG Y+ GG + GT EV IQ S+ TR+GV+R +R+AFE + Sbjct: 131 GKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAFEYCRK 190 Query: 181 R-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R+ +T K+N L + W+ + E YP+I D H+D +C V PE FDV Sbjct: 191 RGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNPEWFDV 250 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDI++DLG G +GIA NLNPE S+FEP+ GSAP GKN+ NP+A Sbjct: 251 IVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPE--GVSMFEPIGGSAPKYTGKNVINPLA 308 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA-TTPQVADAICKI 358 + AGAMML+ LG A I A+++V A K+ T +V D + Sbjct: 309 AVCAGAMMLEQLGETG-----AAARIEEAVKKVCAGHLKSLAAGRMGYGTDEVGDLVVSH 363 Query: 359 I 359 + Sbjct: 364 L 364 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 113/375 (30%), Positives = 173/375 (46%), Gaps = 41/375 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ IPGDGIG EV VL+A G L + ++E A E +G +P E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVE-AGVEVIEKYGTPLPPQVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G +G P + R+E D Y NLRP + PG+ P Sbjct: 58 SIRETRVAIKGPIGTP----VGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSP-----F 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTE----------------HEVVIQESVFTRRGVD 168 DID VVRENTE Y+ + I + G Sbjct: 109 QDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSR 168 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 RI+++AFE A+ RK +T+ K+N + + + + +A+ YP+I ++ +D +C Sbjct: 169 RIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCL 228 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + +P+ +DV+V +NL+GDI+SDL G +G+AP AN+ ++FE +HGSAP Sbjct: 229 QLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD---GIAVFEAIHGSAPK 285 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM--KGN 345 G+N NP A I +GAMML +LG + + + VIA G T D+ Sbjct: 286 YAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAV-----QSVIAEGKYVTYDLAQGEP 340 Query: 346 ATTPQVADAICKIIL 360 T ++A+AI + Sbjct: 341 VGTQEMAEAIAARVQ 355 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 124/359 (34%), Positives = 179/359 (49%), Gaps = 31/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+M+IA IPGDGIG EV+ + +L L F + A G +P++ Sbjct: 1 MKSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHAD-AGDACLKRTGTALPEE 55 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E + A FGA G S +++ RREFD + NLRPV+ PGVPC Sbjct: 56 TLEAVGEARATLFGAAG--------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY-- 105 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D+DF +VRENTE Y E + + + TR RI ++AF+ AQ Sbjct: 106 ---PDLDFVIVRENTEDLYVGDE-----EYTPEGAVAKRIITRTASRRISQFAFQYAQKE 157 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + +T+ K+N L + + + +A YP++ ++D + QP+ F +V Sbjct: 158 GMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIV 217 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G +G+APSAN+ + +LFEPVHGSAP I GKNIANP A I Sbjct: 218 TTNLFGDILSDEAAGLIGGLGLAPSANIGEK---NALFEPVHGSAPQIAGKNIANPTAMI 274 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +ML L +Q I A+++ +A G TPD+ G T ++A I + + Sbjct: 275 LTTTLMLKHLNK-----KQEAQKIEKALQKTLAEGLVTPDLGGKLGTMEMAAEIARHLE 328 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 126/366 (34%), Positives = 188/366 (51%), Gaps = 29/366 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 MM ++ I GDGIGKEV+PE I++L E A E +G +P+ Sbjct: 1 MM---KVCVIEGDGIGKEVIPEAIKILNELGEFEIIKGE------AGLECLKKYGNALPE 51 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP-----GV 115 D E+ D I FGA+ P + + ++ R+ F Y N+RP+ F G Sbjct: 52 DTIEKAKEADIILFGAITSPK-PGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGK 110 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 +ID ++RENTE Y E++ I E V TR+G +RI+R+AF Sbjct: 111 IADYEFLNAKNIDIVIIRENTEDLYVGRER-----LENDTAIAERVITRKGSERIIRFAF 165 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A RK ++ K+N L I+ + E + ++Y I D +D + PE Sbjct: 166 EYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPE 224 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V +N+FGDILSD A G +G+APSAN+ ++ +LFEPVHGSAPDI GK IA Sbjct: 225 KFDVIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK---ALFEPVHGSAPDIAGKGIA 281 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP+A+I + AM+ D++G ++ + I A++ + + TPD+ G+ T V D I Sbjct: 282 NPMASILSIAMLFDYIGEKEK-----GDLIREAVKYCLINKKVTPDLGGDLKTKDVGDEI 336 Query: 356 CKIILR 361 I + Sbjct: 337 LNYIRK 342 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 180/359 (50%), Positives = 218/359 (60%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ IA IPGDGIG++V +VL A GF L+ W SC +Y G MMP D Sbjct: 1 MKSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPW-SCAFYKETGAMMPPD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L RFDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL GV PL Sbjct: 60 GIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLKA 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV++GT EV ++ S+FTR GV+RILR+ F+ A+ R Sbjct: 120 ---EGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQARQR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ L S TKSN SM WDE +A YP++ HID + AR VM PE DVVV Sbjct: 177 -RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLDVVV 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMMLD LG +A ++ A+E A G T G T + A+ + Sbjct: 296 WSGAMMLDHLGQ-----ARAARKVIEALERTTARGIGTVP--GKNRTETITAAVLAALD 347 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 124/369 (33%), Positives = 180/369 (48%), Gaps = 20/369 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 199 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ GA+G H+ LL+ R + NLRP + P + Sbjct: 200 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLG-GRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D VVRE T G Y G E+ V+ +DRI R AFE Sbjct: 260 TLKKEVAEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFE 319 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 AQ R R L S K+N L SM W +RV AMA YP++ ++D + V P++ Sbjct: 320 TAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQ 377 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FD +V +N+FGDILSD TG+IG+ PSA++ P LFEP+HGSAPDI G++ AN Sbjct: 378 FDTIVTNNIFGDILSDEASMITGSIGMLPSASVGES--GPGLFEPIHGSAPDIAGQDKAN 435 Query: 297 PIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGN--ATTPQV 351 P+AT+ + AM+L + LG G+ A I A+ + + G +T D+ G ++ Sbjct: 436 PLATVLSAAMLLRYGLGEGN-----AAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEM 490 Query: 352 ADAICKIIL 360 + + K + Sbjct: 491 GEQVLKAVE 499 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 382 bits (982), Expect = e-104, Method: Composition-based stats. Identities = 133/356 (37%), Positives = 194/356 (54%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RI I GDGIG EV+P RVL+A G L F + E A E + G +P++ E Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA----TGLPLEFVEAE-AGWETFERRGTSVPEETVE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ A FGA P +G++ RR D Y N+RP + P Sbjct: 58 KILSCHATLFGAATSPTRKVP--GFFGAIRYLRRRLDLYANVRPAKSRP------VPGSR 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D +VRENTEG Y R +V I ++V +++ +RI R A +A+ RPRK Sbjct: 110 PGVDLVIVRENTEGLYVEQERRY-----LDVAIADAVISKKASERIGRAALRIAEGRPRK 164 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 TL A K+N L ++ + + V+ +A+++P + +D + VM+PERFDV+V +N Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GDILSDL G +G+APS N+ ++FEPVHGSAPDI GK IANP A I + Sbjct: 225 LLGDILSDLAAGLVGGLGLAPSGNIGD---TTAVFEPVHGSAPDIAGKGIANPTAAILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMMLD+LG ++A + A++ V+ GP+TPD+ G+ATT +A+ + + Sbjct: 282 AMMLDYLGE-----KEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALK 332 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 380 bits (977), Expect = e-104, Method: Composition-based stats. Identities = 185/359 (51%), Positives = 233/359 (64%), Gaps = 12/359 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M MR+A IPGDGIG +V E ++V+ +A G + + + ++ SCE Y+ G MMP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA---TGGRIEWTEFDY-SCERYAKTGAMMPP 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L+ FDAI GAVG+P VPD +SLWG L+ RR F+QYVNLRPVRL PG+ PLA Sbjct: 57 DAPTTLAGFDAILLGAVGYP-GVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLA 115 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + +VRENTEGEYS +GG N G ++E +QESVFTR G +RI+RYAFELA S Sbjct: 116 GVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAFELAAS 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + SATKSNG+ SMPYWD +A YP+ H+D L AR V P DV+ Sbjct: 176 AGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPASLDVI 234 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDL A TG +G+A S N+NPERT S+FE VHGSAPDI G+ IANP+A Sbjct: 235 VASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQ 294 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I AGAM+LD L N I A+++V++ G +TPD+ G ATT Q+ AI + Sbjct: 295 ILAGAMLLDHLNE-----PATANKIRLAVDQVLSDGRVRTPDLGGTATTEQLGTAIAEA 348 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 378 bits (972), Expect = e-103, Method: Composition-based stats. Identities = 117/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ R+++A G + +E + + +PDD E + Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + G + P + + R+ F+ + N+RPVR P VP P G + Sbjct: 79 KRTRVVLKGPLETP----VGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG---RN 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+++ R G V I + + +G ++I+R+AFELA++ RK + Sbjct: 132 IDLVVVRENIEDLYAAIEYRETPG----VTIAHKLISYKGSEKIIRFAFELARAEGRKKV 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T ATKSN L ++ ++ E +A YP+I + ID + V PE+F+V+V +NL Sbjct: 188 TCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLN 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDI+SDL G +G A S N E ++FEPVHG+AP GKN+ NP A I M Sbjct: 248 GDIISDLASGLVGGLGFAASGNYGHE---VAIFEPVHGTAPKYAGKNVINPTAMILTAVM 304 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGN---ATTPQVADAICKIILR 361 ML ++ + I A+ + G T D+ G+ +T DAI + R Sbjct: 305 MLRYIDEFET-----AETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGR 358 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 110/359 (30%), Positives = 172/359 (47%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + I GDGIG E+ + AA + +E ++ +PDD Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAA----NAPIKWEPVDVTPI--LKDGKTAIPDDAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G + P L RR F+ + N+RP R G P Sbjct: 108 ESVRRNYVALKGPLATP----VGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---- 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V +G VV + T+ +R+LR+AF+ A+S + Sbjct: 160 -DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITKEASERVLRFAFQYARSINK 214 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 K + K+ + +S + +A+++P++ +D + +D C + V P ++ V+V Sbjct: 215 KKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLV 274 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A + Sbjct: 275 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDE---CSIFEAVHGSAPDIAGKGLANPTALL 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +G + I AI + +A G T D+ G A T + A+AI K + Sbjct: 332 LSSIMMLQHMG-----LHEHAGRIQKAIFDTLAEGKALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 170/366 (46%), Gaps = 30/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + GDGIG E++ + VL+ AA L E +E Y ++ + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D Q+ R A+ G V P + R+ Y N+RP + P Sbjct: 57 DTWSQIFRTKALLKGPVTTPQ----GGGYKSLNVTLRKTLGLYANVRPSCSY----FPFV 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +ID ++REN E Y+ + + + +R G ++I+R+AFE A Sbjct: 109 NTSAPEIDVVIIRENEEDLYAGIEY----HHTADTYESVKLISRSGSEKIIRFAFEYALK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RKT++ +K N + + + + +A Y I+ D IDI AR + P++FDV+ Sbjct: 165 NNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDILSD+ +G+IG+A SAN+ + ++FE VHGSAPDI G+NIANP Sbjct: 225 VTSNLYGDILSDIAAKISGSIGLAGSANIGKDY---AMFEAVHGSAPDIAGQNIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + A MML LG + I A+++ I G T D+ T + A A Sbjct: 282 LNAAIMMLVHLG-----LTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQA 336 Query: 355 ICKIIL 360 I + Sbjct: 337 IINNLE 342 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 144/359 (40%), Positives = 194/359 (54%), Gaps = 24/359 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +I I GDGIG EV+P VL+A G F + A E + G +P+ Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA----TGLKFEFVEA-QAGWETFERIGTSVPE 55 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E ++ DA FGA P +G++ RR+ D + N+RP + P Sbjct: 56 ATLEAVTHTDATLFGAATSPTKKVP--GFFGAIRYMRRKLDLFANVRPAKHHP------V 107 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D VVRENTEG Y EG E+ I ++V TR+ RI YA LA S Sbjct: 108 PGSRPGVDLIVVRENTEGLYVEQERSYLEG---EIAIADTVITRKASARIGEYAARLAAS 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK L A K+N L ++ + V A A +PE++ ID + V PERFDV+ Sbjct: 165 RPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPERFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDI+SDL G +GIA S N+ + ++FEPVHGSAPDI GK IANP AT Sbjct: 225 VTTNLFGDIISDLTAGLVGGLGIAASGNIGIKH---AVFEPVHGSAPDIAGKGIANPAAT 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 I +G MMLD LG +A + AA+++V+ GP+TPD+ GNATT Q A+A+ + + Sbjct: 282 ILSGVMMLDHLGE-----HEAARRVEAAVDKVLQEGPRTPDLGGNATTLQFAEAVARSL 335 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 376 bits (965), Expect = e-102, Method: Composition-based stats. Identities = 102/358 (28%), Positives = 164/358 (45%), Gaps = 27/358 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + ++ PG GIG E+ + AA + +E E + G ++ ++ Sbjct: 303 QNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEA-GDLIKEES 357 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G P + R++ + + N+RP R GV P + Sbjct: 358 LNAVINYKWGLKGPFATPI----GKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYSN- 412 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +RENTEGEYS L V G VV + ++ + I RYAFE A+ Sbjct: 413 ----VDLVTIRENTEGEYSGLEHAVVPG----VVENLKIISQPACENIARYAFEFARKNN 464 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK + + K+ + + + ++ YPEI + ++ ID +C + PE FDV+V Sbjct: 465 RKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEVFDVMVM 524 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDI+SDL G +G+ S N++ +++E VHG+APDI G N ANP A + Sbjct: 525 PNLYGDIVSDLCAGLIGGLGLTASGNISH---TCAVYEAVHGTAPDIAGLNKANPTALLL 581 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 +G MML +G Q+ I A+ + ++ G T D+ G ATT A+ I Sbjct: 582 SGVMMLKAMG-----LQKEGFAIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 175/358 (48%), Gaps = 15/358 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T I A+PGDGIG E+L + +L+ + ++ F E E+ G+ + + Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGAS-IDTFGEPLTEKTL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC--PLAG 121 R DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKA 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++ D +VRE T G Y N + +TR ++RI+ AF+LA SR Sbjct: 121 ERVEGTDLVIVRELTSGIYFGEPRYFNNHE----ALDSLTYTREEIERIVHVAFKLAASR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS K N LA S W + V +++ YPE+ + +D + P++FDV+V Sbjct: 177 -RGKLTSVDKENVLASS-KLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ + + P L+EP+HGSAPDI GKN+ANP I Sbjct: 235 YENLFGDILSDEASVIPGSLGLSPSASFSND--GPRLYEPIHGSAPDIAGKNVANPFGMI 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + AM L A + + I +I HG T D+ G T + + + + + Sbjct: 293 LSLAMCLR----ESLNQPDAADELEQHIYNMIEHGQTTADLGGKLNTTDIFEILSQKL 346 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 177/359 (49%), Positives = 224/359 (62%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT RIA +PGDGIG++V VL+ A GF+L + W SC+YY +G MMP D Sbjct: 1 MKTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPW-SCDYYLENGSMMPAD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL PGV PL Sbjct: 60 GIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPL-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGR+++G ++EV I+ ++FTR+GV+RILR+ FE A++R Sbjct: 118 -RSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQARAR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L S TKSN SM +WDE ++ YP++ HID + AR VM PE DVV Sbjct: 177 -RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLDVVA 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMML+ LG A ++ AIE A G + G T + ++ + Sbjct: 296 WSGAMMLEHLGET-----AAAEKVMDAIETTTARGV--GAIPGKDRTDAITASVLSALG 347 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 121/360 (33%), Positives = 181/360 (50%), Gaps = 19/360 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M++A +PGDGIG EV ++VL+A E G L++E + G+ P+ + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGG-AAIDAFGEPFPEPTRK 59 Query: 65 QLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 + +A+ G+VG P P I LL R+ D + NLRP ++FPG+ PL Sbjct: 60 GVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D +VRE T G Y G +++ V+R+ R AFE A+ Sbjct: 120 EEIARGVDVLIVRELTGGIYFGEP----RGMSEAEAWNTERYSKPEVERVARVAFEAARK 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R RK + S K+N L + +W + VE + YP++ + Q++D + V P RFDVV Sbjct: 176 R-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVV 233 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V N+FGDILSDL G++G+ PSA+L +FEPVHGSAPDI GK IANP A Sbjct: 234 VTGNIFGDILSDLASVLPGSLGLLPSASLG---RGTPVFEPVHGSAPDIAGKGIANPTAA 290 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 I + AMML+ + + A+ + + P PD+ G+A T + + + Sbjct: 291 ILSAAMMLEHA----FGLVELARKVEDAVAKALLETP-PPDLGGSAGTEAFTATVLRHLA 345 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 124/366 (33%), Positives = 189/366 (51%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA +PGDGIG EV+ E ++VL+ ++ G + G+ +P++ + Sbjct: 1 MKIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGG-DAIDRFGEPLPEETKK 59 Query: 65 QLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 DAI+ G+VG P P+ G LL R+ + Y N+RP++++ + PL Sbjct: 60 ICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPL 119 Query: 120 AGKQPG-DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 K G +D VRE + G Y G + E ++ R+ V+RI R AFE+A Sbjct: 120 KEKVIGSGVDLVTVRELSYGVYYGQP----RGLDEEKGFDTMIYDRKTVERIARTAFEIA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 RK +TS K+N L SM W + V +A YP++ ++D + +++P +FD Sbjct: 176 -KNRRKKVTSVDKANVLYSSM-LWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ +N+FGDILSD A G++G+ PSA+ + L+EP GSAPDI GKNIANPI Sbjct: 234 VILTTNMFGDILSDESAALPGSLGLLPSASFGDKN----LYEPAGGSAPDIAGKNIANPI 289 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK----GNATTPQVADA 354 A I + AMML+ + I A+E VI G +T D+ +T Q+ D Sbjct: 290 AQILSLAMMLEH----SFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDL 345 Query: 355 ICKIIL 360 ICK + Sbjct: 346 ICKKLE 351 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 123/367 (33%), Positives = 175/367 (47%), Gaps = 21/367 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA + GDGIG EV+ E +VL A ++ F ++ + + +HG +PD Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGG-AAIDNHGNALPDSTMAG 61 Query: 66 LSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL--- 119 DAI FG+VG P P +LL R FD + N+RP L P + Sbjct: 62 CIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLR 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + D V+RE T Y E E ++RR V RI AF+ AQ Sbjct: 122 SDISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQ 181 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R +TS K+N LA S W + VE +A YP++ + ++D + V P +FDV Sbjct: 182 KRN-NKVTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 ++ NLFGDILSD+ TG++G+ PSA+LN + ++EP GSAPDI G +ANPIA Sbjct: 240 MLCPNLFGDILSDICAMITGSMGLLPSASLNSD--GFGMYEPAGGSAPDIAGLGVANPIA 297 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVAD 353 I + A+ML + A I A+ + +G T D+ K +T +V D Sbjct: 298 QILSAALMLRY----SLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGD 353 Query: 354 AICKIIL 360 ICK I Sbjct: 354 YICKQIE 360 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 116/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG E + ++VL+AA L++E E + + +P + E + Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + G + P + + R+ F+ Y N+RPVR FP VP P AG Sbjct: 78 RKTRVVLKGPLETP----VGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG---RG 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+ + V + + +G ++I+R+AFELA++ RK + Sbjct: 131 IDLVVVRENVEDLYAGIEHMQ----TPSVAQTLKLISWKGSEKIVRFAFELARAEGRKKV 186 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 ATKSN + ++ E +A+ YP+I +D + V +PE+F+V+V +N+ Sbjct: 187 HCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMN 246 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSDL G +G APSAN+ E ++FE VHGSAP GKN+ NP A + + M Sbjct: 247 GDILSDLTSGLIGGLGFAPSANIGNE---VAIFEAVHGSAPKYAGKNVINPTAVLLSAVM 303 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVADAICKIILR 361 ML +L + I A+ + G T D+ G A T + +AI + + + Sbjct: 304 MLRYLEEF-----ATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 118/358 (32%), Positives = 183/358 (51%), Gaps = 23/358 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K R+A I GDG+G +V+ + VL A +++ + + A +G +P + Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPA-VAGLNTVEKYGTNLPKET 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L D + G P+ SL + + R+ FD Y ++RP + P VP Sbjct: 63 LDTLKETDCVLKGPTTTPE---GANSLPSANVGIRKYFDLYADVRPNKTLPNVPS----- 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +VRENTEG YS L RVN+ T I V TR+ +RI++YAF+LA+SR Sbjct: 115 IKPNVDMVIVRENTEGMYSGLDFRVNQETT----IGIRVITRKACERIVKYAFKLAESR- 169 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +K +T K N L +S + + A+ +P+++ D H+D + F+ QPE +DV+V Sbjct: 170 KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFYDVIVT 229 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI+SD G IG SAN+ + ++FEP+HGS P G + NPI TI Sbjct: 230 ENLFGDIISDEAAMVVGGIGTGASANIGDKY---AMFEPIHGSVPKYTGMDKVNPIGTIM 286 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 + MMLD++ ++A I A+ +V+ G T D+ G A +V I + Sbjct: 287 SVKMMLDWMDY-----KEAGKAIEDAVYKVLEEGKILTYDLGGTAKCSEVGKEIASKV 339 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 123/364 (33%), Positives = 183/364 (50%), Gaps = 18/364 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I IPGDGIGKE+ + VL+ E++G LS+ + Y G +PDD Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKDAGGTAY-DKFGTPLPDDTI 60 Query: 64 EQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 E D + FGAVG + ++L R+ Y NLRPV++ + PL Sbjct: 61 EACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +D +VRE G Y + E ++ VDRI + AFE A+ Sbjct: 121 KPELVKGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETAK 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R +TS K+N LA S W V +AE+YP++ + ++D + ++P +FDV Sbjct: 181 LR-RGKVTSVDKANVLATSR-LWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDV 238 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V NLFGDILSD G+IG+ PSA++ T SL+EP+HGSAPDI GK IANP+ Sbjct: 239 IVTGNLFGDILSDEAAVVGGSIGMMPSASIG---TSTSLYEPIHGSAPDIAGKGIANPMG 295 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAI 355 TI + AM+L + + + + + A +A G +TPD+ A T ++ I Sbjct: 296 TILSAAMLLRYSLHEEAAAKAIEAAVDKA----LADGYRTPDLWKEGFQKANTEEITKVI 351 Query: 356 CKII 359 C+ I Sbjct: 352 CERI 355 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 370 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 179/322 (55%), Positives = 212/322 (65%), Gaps = 6/322 (1%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT +A IPGDGIG +V + VL AAA + FA W SCEYY HG+MMP+D Sbjct: 1 MKTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPW-SCEYYLEHGRMMPED 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAIY GAVGWP TVPD +SL G LL R+ F+QY N+RP RL GV PL Sbjct: 59 GIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLKA 118 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV+EG +EV ++ SVFTR GV+RILR+ FE A+SR Sbjct: 119 ---EGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQARSR 175 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS TKSN SM +WDE +A YP++ HID + A+ VM P+ DVVV Sbjct: 176 -RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLDVVV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI GKNIANPIA I Sbjct: 235 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHN 323 W+ A MLD LG + Sbjct: 295 WSVAQMLDHLGEAEVSAAVLSA 316 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 178/367 (48%), Gaps = 18/367 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDGIG EV+ VLQ A G F++M G +P++ Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGG-AALDLVGVPLPEET 103 Query: 63 HEQLSRFDAIYFGAVGWPDTVP--DHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 DAI GA+G H+ +L RR+ + NLRP + P + Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDAST 163 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVN-EGTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + EV + ++ +DRI R AFE Sbjct: 164 LKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFET 223 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R R L S K+N L S+ W +RV A+A YP++ ++D + + P++F Sbjct: 224 ARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +N+FGDILSD TG+IG+ PSA+L P LFEP+HGSAPDI G++ ANP Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGES--GPGLFEPIHGSAPDIAGQDKANP 339 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVAD 353 +ATI + AM+L + ++A I A+ + + G +T D+ ++ + Sbjct: 340 LATILSAAMLLKY----GLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGE 395 Query: 354 AICKIIL 360 + K + Sbjct: 396 EVLKSVE 402 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 164/352 (46%), Positives = 224/352 (63%), Gaps = 12/352 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M + +PGDG+G EV+ E + L A +++ + W +++ HG MMP D + Sbjct: 1 MNVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPW-GSAWWAEHGTMMPADAID 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L DAI GAVG P VPD +LWG +LK R+E D +VN+RP RL G+P PLAG+ P Sbjct: 56 VLRGHDAILMGAVGDP-AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAP 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D+D VREN+EGEY+ +GGRV+ G H+V I+ SVFTRRG +R++RYAF +A +R + Sbjct: 115 HDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASAR-KG 173 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L +ATKSN P+WDE V + +P + D+ +D L AR + P DVVVASN Sbjct: 174 VLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVVASN 233 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDIL+D+ A G +G+A SANL+P P+LFEPVHGSAPDI G+ IANP+ IW+ Sbjct: 234 LFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSA 293 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A+ML+ LG G+ ++ A+E V GP+T D+ G ATT +V DA+ Sbjct: 294 ALMLEQLGAGEG-----SRRLMDALETVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 159/356 (44%), Positives = 226/356 (63%), Gaps = 15/356 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +I IPGDGIG EV+ E ++ Q+ + + ++W ++Y GK++P D+ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL----NLPIQRDYVDW-GIQHYLKTGKVVPIDYI 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 +Q+ ++DAI G++G P T+PD+++L L++ R++ DQ++ LRP + FPG+P PL Sbjct: 65 DQVKQYDAILLGSLGDPRTLPDYVTLE-PLIQMRQQLDQFLCLRPAKHFPGIPTPLKKC- 122 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +ID VVREN+EGEYS++GG GT E I+ +V TRRG++R++RYAFE ++ R R Sbjct: 123 --EIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEASRKR-R 179 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T ATKSN + M WD EA+A YP++ +K ++D L A V P +FDV+V S Sbjct: 180 NHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGS 239 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLF DI+SDL G++GIAPSAN+NPERTFPSLFEPVHGSA DI GK I +PI T+ A Sbjct: 240 NLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRA 299 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +MML+FLG +E I AI+ I T D+ G TT +V + I I Sbjct: 300 SSMMLEFLGYSEESV-----LIEEAIQSSILQKITTIDIGGTKTTNEVGNFIADYI 350 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 135/371 (36%), Positives = 188/371 (50%), Gaps = 29/371 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 I IPGDGIG+EV+P + VL+A G FE + A E + G+ +P Sbjct: 4 APYTILVIPGDGIGREVIPAAVAVLRA----TGLPFHFENAD-AGWECFQRQGEALPSAT 58 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI FGAV P +++ RRE D Y N+RPV F +P + Sbjct: 59 LTAARAADAILFGAVASPGY--PVAGYRSPIVRLRRELDLYANIRPV--FDDLPENGSNP 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR- 181 + +D VVRENTE Y+ ++G I E V TRR RI+R A +LA++R Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGAT---AIAERVITRRASARIMRVACDLARARR 171 Query: 182 --------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 P +T K+N L + + +A+ YP+++ D+ +D + + Sbjct: 172 SARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATR 231 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 PERFDV+V +NLFGDILSD+ A G +G+APSANL +LFEPVHG+APDI GK Sbjct: 232 PERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH---ALFEPVHGAAPDIAGKG 288 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAH-----NGILAAIEEVIAHGPKTPDMKGNATT 348 IANP+A I A++LD L + I AI V A GP TPD+ G+A T Sbjct: 289 IANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVT 348 Query: 349 PQVADAICKII 359 + +A+ + Sbjct: 349 TDITNAVLSHM 359 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 160/355 (45%), Gaps = 13/355 (3%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI + GDG+G EV+ VL +G + + G+ +P Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGV-AIDLTGQPLPQRTLAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 DA+ GAVG P LL R+ + N+RPV + K Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +IDF VVRE T G Y S EV + R ++RI+ YAF+LA R +K Sbjct: 123 EIDFVVVRELTGGIYFSYPKER----TEEVATDTLTYHRHEIERIVSYAFQLANKR-KKK 177 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +TS K+N L S W E +A YP + + +D + P RFDV+V NL Sbjct: 178 VTSIDKANVLESS-KLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTENL 236 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSD G++G+ PSA+ PSL+EP+HGSAPDI GKN ANPIA + + A Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAE--KGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML + I A+ V+ G T D+ G TT A+ + + Sbjct: 295 MML----GQSFGLTREGYAIEEAVSAVLKSGKCTADIGGTETTTSFTKAVIQEME 345 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 368 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 121/364 (33%), Positives = 184/364 (50%), Gaps = 13/364 (3%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 T+ IA +PGDGIG+EV+P + ++ AA G Q A +YY+ G +P Sbjct: 6 DTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPAST 65 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + DAI FGA+GWPD + L R E + +RP+R FPG+P L Sbjct: 66 LDACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDP 125 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + IDF +VRE TEG + + G E E TR G R+ +AF++A+ R Sbjct: 126 RAEQIDFVLVREQTEGLFYARGR--GEIRNDEEAYDTMQITRSGTQRVTEFAFDIARQRK 183 Query: 183 RK----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R+ +T K+N SM ++ + + +A+ + ++ D ++D L V +P FD Sbjct: 184 RRGKPGNVTCVDKANVF-QSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKPWTFD 242 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APSA++ + LF+P HG+APDI GK ANP Sbjct: 243 VLVTENMFGDILSDLAAGLIGGMGMAPSADIGDKH---GLFQPAHGTAPDIAGKGCANPS 299 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAI 355 A + AMMLD+L A + A+E ++ P + GNA ++ ++ Sbjct: 300 AMFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPMEYGGNANCAEMTRSV 359 Query: 356 CKII 359 + Sbjct: 360 ISSL 363 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 127/356 (35%), Positives = 188/356 (52%), Gaps = 31/356 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWH 63 MR+A I GDGIG+E++P ++VL A F L FE++ + G + ++ Sbjct: 1 MRLAVIEGDGIGREIIPAAVKVLDA------FGLEFEKVPLELGYTRWERTGTAISNNDL 54 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + DA+ FGA+ + LL R+E D Y N+RPV+ PG+ Sbjct: 55 ETIKGCDAVLFGAITT----VPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGV---TG 107 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 D DF +VRENTEG YS + E+ + V TR+G +RI YA +LA+ R + Sbjct: 108 RNDFDFIIVRENTEGLYSGIE-----EIGPELSWTKRVVTRKGSERIAEYACKLAKKR-K 161 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 LT KSN L S + + A + ++ +D + +M+PER+D+VV + Sbjct: 162 NKLTIVHKSNVLK-SDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVTT 219 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLFGDILSD+ A G++G+ PSAN+ + + FEPVHGSAPDI GK IANP+A I Sbjct: 220 NLFGDILSDMCAALVGSLGLVPSANIGEKY---AFFEPVHGSAPDIAGKGIANPLAAILC 276 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L+++G I AI V+ TPD+ G A+T +V +A+ + + Sbjct: 277 VKMLLEWMGEPR------SQIIDEAIAYVLQKKIITPDLGGTASTMEVGNAVAEYV 326 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 155/384 (40%), Positives = 219/384 (57%), Gaps = 32/384 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ I GDGIG EV+ EG +V+ AA E + F + + M + S ++Y G+ + + Sbjct: 1 MVSYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPF-SADHYVKTGETISES 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++LS++ AI+ G++G V + G LL R +DQYVNLRPV+L GV PL G Sbjct: 60 SLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-----------------------HEVVIQ 158 K DIDFYVVRENTE Y +GGR +GT E+ Q Sbjct: 120 KTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQ 179 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 V ++ G RI+ Y+F+LA SRP+K L+S K+N L +W E A YP+++ Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 D ++D + FV PE FDVVV+ N+FGDI++DLG G +G+AP N+NPE S+ Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPE--GTSM 297 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GP 337 FEP+ GSAP G N NPIATIWAGAM+L+ LG +QA GI+ AIE+ + Sbjct: 298 FEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGE-----KQAAAGIVDAIEQNLKEKKI 352 Query: 338 KTPDMKGNATTPQVADAICKIILR 361 +T D+ G+A T V I +I+ + Sbjct: 353 RTYDLGGSAGTSDVGTDIARIVKQ 376 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 106/366 (28%), Positives = 164/366 (44%), Gaps = 30/366 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK + I GDGIG E++ ++V+ A G L E++E Y + + Sbjct: 1 MKKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVYSMGNPSGIEPS 56 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L R + P + R+ Y N+RP + P Sbjct: 57 SWESLKRTKVFLKAPITTPQ----GGGFKSLNVTVRKALGLYANIRPCISY----APFIH 108 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + ID ++REN E Y + R + + TR+G +RI+RYAFE A+ Sbjct: 109 TKHPGIDLVIIRENEEDLYGGIEHRQGV----DSFQALKIMTRQGTERIIRYAFEYARCY 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK ++S TK N L I+ + + E +A+ YP+I + IDI A+ P+ FDV+V Sbjct: 165 GRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQSFDVLV 224 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NL+GDILSD+ G++G+ SAN+ E S+FE +HGSAP G+N+ANP + Sbjct: 225 LANLYGDILSDVAVQIAGSVGLGASANIGHEY---SMFEAIHGSAPRRAGQNVANPSGLL 281 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAI 355 A ML +G + + A + I G T D+ T + A + Sbjct: 282 LAAVQMLIHIGQ-----NAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREFARHV 336 Query: 356 CKIILR 361 K + + Sbjct: 337 IKNLGK 342 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 366 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 107/367 (29%), Positives = 170/367 (46%), Gaps = 30/367 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + I GDGIG E++ + +L+ A R + E +E Y H+ + + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E + R I + P + R+ + N+RP F P Sbjct: 57 QSWESIERTGVILKAPITTPQ----GGGYKSLNVTIRKTLQLFANIRPSVSFY----PFT 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +++ ++REN E Y+ + R H + + +R G ++I+RYAFE A Sbjct: 109 KTLHPNLNLTIIRENEEDLYAGIEYRQ----THNMYESVKLISRTGCEKIIRYAFEYAVK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T +K N + S + + +A+ YP+I + IDI AR +PE FDV+ Sbjct: 165 NNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDI+SD+ +G++G+A SAN+ ++FE VHGSAPDI G++IANP Sbjct: 225 VTSNLYGDIISDVAAEISGSVGLAGSANIGEHY---AMFEAVHGSAPDIAGQDIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADA 354 + A MML +G GD I A ++ I G T D+ T + A+ Sbjct: 282 LNAAIMMLVHIGQGD-----IATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAEE 336 Query: 355 ICKIILR 361 + K + + Sbjct: 337 VVKRLGQ 343 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 365 bits (937), Expect = 2e-99, Method: Composition-based stats. Identities = 151/359 (42%), Positives = 208/359 (57%), Gaps = 11/359 (3%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +R+A IPGDGIG EV+ + L+AA E G L +W E Y G MP D Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGG-ERYLRQGAAMPPDA 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + DA+ FGAVG PD VP+H +WG ++ R++ D VNLRPVR FPGVP + Sbjct: 65 ADLVKKTDAVLFGAVGRPD-VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +VRENTEGEY GG + G+ H++ I+ +V +RR ++R AF LA R Sbjct: 124 --DGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFALAGRRS 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L TKSN + P WD V + E YP + + +D + AR + P DV++A Sbjct: 182 -GRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLA 240 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDL G +G+APSAN+ P+ P ++EPVHGSAPDI GK +ANP+A + Sbjct: 241 SNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIIL 360 +GAM+L+ LG+ D A + A+ + + T D+ GNATT VA A+ + Sbjct: 301 SGAMLLEDLGHTD-----AARRVRDAVADTLRDTRHHTADLGGNATTADVASAVLHTME 354 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 102/364 (28%), Positives = 167/364 (45%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG E+ + +L AA G L E +E Y + +P + Sbjct: 20 TPIPVTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEA 75 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + ++R + G + P + R+ Y N+RP R + P+ Sbjct: 76 WDSIARTRVMLKGPITTPQ----GGGYKSLNVTMRKTLGLYANVRPCRTYK----PIVTT 127 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + D+D +VREN E Y+ + R +V + TR G +RI RYAFE A+ Sbjct: 128 RHPDMDVVIVRENEEDLYAGIEHRQ----TQDVAQCLKLITRSGSERIARYAFEYARQHG 183 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T K N + ++ + + +A YPEI+ Q +D A FV +PE +DVV+ Sbjct: 184 RSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVLL 243 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDILSD+ TG++G+ S N+ + ++FE +HGSAPD+ +++ANP + Sbjct: 244 PNLYGDILSDIAAQMTGSVGLGGSVNIG---SGGAIFEAIHGSAPDLA-RDVANPSGLLL 299 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG-----NATTPQVADAICK 357 A ML L + ++ A + G T D+ G A T + +A+ + Sbjct: 300 AAVEMLRHL-----KLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVIE 354 Query: 358 IILR 361 + R Sbjct: 355 RLGR 358 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 104/361 (28%), Positives = 170/361 (47%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDGIG E+ ++ AA + +E + + + + +PD Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAA----NVPIEWESCDVSPI--FVNGLTTIPDPAV 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + +++ G + P L R+ F + N+RP + G Sbjct: 90 QSITKNLVALKGPLATPI----GKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---- 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V G VV + TR +R++RYAFE A++ R Sbjct: 142 -ENVDLVLIRENTEGEYSGIEHIVCPG----VVQSIKLITRDASERVIRYAFEYARAIGR 196 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 + KS ++ + + +++ YP++ + + ID + V P + V V Sbjct: 197 PRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSV 256 Query: 242 ASNLFGDILSDLGPAC-TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 NL+GDILSDL G++G+ PSAN+ + S+FE VHGSAPDI G++ ANP A Sbjct: 257 CPNLYGDILSDLNSGLSAGSLGLTPSANIGHK---ISIFEAVHGSAPDIAGQDKANPTAL 313 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP--KTPDMKGNATTPQVADAICKI 358 + + MML+ +G + I A+ IA GP +T D+ G ATT +A+ K Sbjct: 314 LLSSVMMLNHMG-----LTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKR 368 Query: 359 I 359 + Sbjct: 369 L 369 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 163/358 (45%), Positives = 211/358 (58%), Gaps = 10/358 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+++A IPGDGIG EV+ EG++VL A A R G L + E + + G+++PD Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYEL-GAQRWHATGEVLPDAV 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L + DAI GAVG P VP + G LL+ R F YVNLRPVRL+PGV PLAG Sbjct: 63 EEELRQHDAILLGAVGDPT-VPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGV 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 P DID VVRE TEG Y+ +GG + +GT HE+ Q+SV TR GV+R++RYAF A RP Sbjct: 122 APEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERP 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 LT K N L + W V + YP++ D H+D FV QP RFDVVV Sbjct: 182 CHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVT 241 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI++DLG A G IG+A S N+NPE FPS+FEPVHGSAPDI G+ A+P ATI Sbjct: 242 DNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + ++ML+ LG D Q E G + +T Q+ D I + + Sbjct: 302 SVSLMLEHLGYADAAAQIDQAVAEDLQERAKNGGVR--------STTQIGDDIAQRVA 351 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 359 bits (922), Expect = 9e-98, Method: Composition-based stats. Identities = 113/370 (30%), Positives = 175/370 (47%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ +PGDGIG E + E +V+ E+ C Y HG+ + D Sbjct: 1 MASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAY-DAHGQAISDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E+ D++ FGAVG P P + LL+ R++ Y NLRP +P + Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA++R R +TS K N + + + E + +++ + D + V P++ Sbjct: 180 LARTR-RNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV++ NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATT 348 IANPIA I + AM L + + + AAI V+ G +T D+ T Sbjct: 299 GIANPIAMIASLAMCLRY----SFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGT 354 Query: 349 PQVADAICKI 358 ++ DAI Sbjct: 355 TEMGDAILAK 364 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 359 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 117/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M IA +PGDGIG E + ++L +++ + + + + + G P Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGG-DAINSEGTPFPK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 + + +AI FGAVG P G+LL R+ F+ + NLRP+ L + Sbjct: 60 STLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKE 119 Query: 117 -CPLA-GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL P ID VRE T G Y + +E +V+ R ++RI A Sbjct: 120 LSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LAQ R RK ++S K+N L SM W E V +A+NYP++ + +ID + + P Sbjct: 180 FKLAQKR-RKRVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNASMQLINNP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 +FD+++ NLFGDILSD +G+IG+ PSA++N L+EP GSAPDI KNI Sbjct: 238 SKFDIILCPNLFGDILSDECAMISGSIGMLPSASINEH--NFGLYEPAGGSAPDIAEKNI 295 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----TTPQ 350 ANPIA I + A++ + + I A+ + + G +T D+ +T + Sbjct: 296 ANPIAHILSIALLFRY----SLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNE 351 Query: 351 VADAICKIIL 360 + D I +I Sbjct: 352 MGDIIAALIK 361 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 359 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 106/350 (30%), Positives = 168/350 (48%), Gaps = 15/350 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I A+PGDGIG E+L + +L+ +E++ F E + ++G + ++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVS-IDYYGTPLTNETL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAG 121 + DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 QSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQ 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +VRE T G Y V + + ++ + ++RI+R AF LA R Sbjct: 121 DIVEGTDLVIVRELTSGIYFGEPSYVKKTE----ALDSLKYSSQEIERIVRIAFNLANRR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK LTS K N L S W + V + ++YPE+ + +D + QP +FDV+V Sbjct: 177 -RKKLTSVDKENVL-SSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ +T L+EP+HGSAPDI ++ ANP + Sbjct: 235 TENLFGDILSDEASVIPGSLGLSPSASFG--QTGTRLYEPIHGSAPDIANEDKANPFGMV 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 + A+ L A N + + + I T D+ G T ++ Sbjct: 293 LSLALCLR----ESLNQNDAANELESIVYSFIQSNKTTADLGGQYRTSEI 338 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 131/368 (35%), Positives = 193/368 (52%), Gaps = 29/368 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K++ I IPGDGIGKEV+P G +VL+ + G + +F +A + + GK +PD+ Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFID-LYAGFQTFQETGKALPDET 80 Query: 63 HEQLSR-FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L FGAV P T ++ RRE + N+RPV+ G Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKV--EGYSSPIVALRREMGLFANVRPVKSVEG------- 131 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ ID +VRENTE Y + +++ T V + RI A ++A Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191 Query: 181 R----PRKTLTSATKSNGLAISMPYWDERVEAMAE----NYPEIRWDKQHIDILCARFVM 232 R + TLT KSN L+ S + E + + E Y +I++++Q +D + R Sbjct: 192 RLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFR 251 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 +P+ FDV+VA NL+GDILSD A G++G+ PSAN+ PE + EP HGSAPDI GK Sbjct: 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGK 308 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQV 351 IANPIATI + A+ML+FLG+ +A I A++ + G KTPD+ G A+T QV Sbjct: 309 GIANPIATIRSTALMLEFLGH-----NEAAQDIYKAVDANLREGSIKTPDLGGKASTQQV 363 Query: 352 ADAICKII 359 D + + Sbjct: 364 VDDVLSRL 371 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 129/359 (35%), Positives = 186/359 (51%), Gaps = 33/359 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQME-WASCEYYSHHGKMMPDD 61 +IA IPGDGIGKEV+ I VL + F+ + A E HG +P + Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDEL------DVDFDYIYGIAGDECNEEHGTPLPQE 62 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + DA FGA G + ++K R+E + NLRPV+ +P Sbjct: 63 TIDIVRDSDACLFGAAG--------ETAADVIVKIRQEMKMFANLRPVKSYPNTKSL--- 111 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++DF +VRENTEG Y + E + I + V TR +RI+ YAF+ A+ Sbjct: 112 --FENVDFMIVRENTEGLYIA----DQEEETEDGAIAKRVITREAEERIIDYAFQYAKDN 165 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R +T+ K+N L + + + + E YP+I + ++D V QP+ F VVV Sbjct: 166 NRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQVVV 225 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G G +G+ PSAN+ + +LFEPVHGSAPDI G+ ANPIA + Sbjct: 226 TTNLFGDILSDEGAGLVGGLGLIPSANIGADG---ALFEPVHGSAPDIAGQQKANPIAMM 282 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +LG D A + AAI +V++ G T D+ G+ATT +VA A+ + Sbjct: 283 LSAIMMLRYLGEND-----AADKFDAAILKVLSEGKTLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 168/370 (45%), Gaps = 18/370 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMP 59 M +I +PGD +G+E+ E I+VL+A ++ R FE G +P Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGG-AAIDATGVPLP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 D+ E + DA+ GAVG P + LLK R+E Y NLRP Sbjct: 60 DEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDL 119 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P+ + DF VVRE G Y V +T V RI R A Sbjct: 120 SPIKPQFAKGTDFVVVRELVGGIYFGKRKE---DDGDGVAWDSEQYTVPEVQRITRMAAF 176 Query: 177 LAQSR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +A P + S K+N LA S + E + +P ++ Q ID V P Sbjct: 177 MALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPT 236 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 + +++ SN+FGDI+SD G++G+ PSA+L + T L+EP HGSAPD+ Sbjct: 237 HLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-P 295 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 KN NPIATI + AMML + I A+++V+ G +T D+ G+ +T +V Sbjct: 296 KNKVNPIATILSAAMML----KLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEV 351 Query: 352 ADAICKIILR 361 DA+ + + + Sbjct: 352 GDAVAEEVKK 361 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 119/366 (32%), Positives = 192/366 (52%), Gaps = 22/366 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK I I GDGIG EV+ + I+ L + R+ S++ + A + G MP + Sbjct: 1 MKK-NIVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNV-LAGAKAIETFGDPMPKE 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-PCP 118 + + DA+ FG++G P P + LLK R+E D Y N+RP+ +PG+ P Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSP 118 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + ++ ++F + RE T G Y GR G E V++ + ++RI +F+ A Sbjct: 119 IKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSFKAA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +SR R +T K+N L S W E ++ MA +Y ++ + +ID + ++ P +FD Sbjct: 176 RSRNR-KMTLVDKANVLETSR-LWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ N+FGDILSD T ++G+ PSA++ ++ SLFEP+HGS P GKNIANP+ Sbjct: 234 VILTDNMFGDILSDEASILTSSLGLLPSASIGSKK---SLFEPIHGSYPQAKGKNIANPL 290 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 I + +MML++ Q N + A++ I TPD+ + +++T +V D Sbjct: 291 GCILSVSMMLEYF-----EMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDY 345 Query: 355 ICKIIL 360 I K I Sbjct: 346 IEKYIK 351 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 112/367 (30%), Positives = 171/367 (46%), Gaps = 17/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ + GDGIG E+ + VLQAA + + ++ E H + Sbjct: 1 MSNLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEI-GFASLKKHKTTFRSE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + D + G D P R+ FD Y N+RP + G Sbjct: 60 VLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLG-----KL 114 Query: 122 KQPG-DIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFEL 177 ++ ID V+RENTEG YS G +V I TR+G RI F+ Sbjct: 115 ERFPMGIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAEIGFKY 174 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A R RK L + K+N L S + E +++ YPE+ + +Q +D + A + P F Sbjct: 175 AMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRDPSVF 233 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV++A+NLFGD LSD G +G+A S N + + HGSAPDI GKNIANP Sbjct: 234 DVILATNLFGDNLSDAASEIAGGLGLAESINAGENY---CIAQAQHGSAPDIAGKNIANP 290 Query: 298 IATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADA 354 ++ I + AMMLD+LG +++ ++ I AI++ I + +T D+ GN +T D Sbjct: 291 VSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDIGGNLSTTDFTDV 350 Query: 355 ICKIILR 361 + + + Sbjct: 351 LISNLKK 357 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 356 bits (914), Expect = 6e-97, Method: Composition-based stats. Identities = 116/365 (31%), Positives = 177/365 (48%), Gaps = 28/365 (7%) Query: 1 MMKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M +T +I IPGDGIG E++ + VL A G ++ A + G + Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL----GSPFEWDSQY-AGMAAIARVGDPL 61 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P + + + G + P ++ R+EF+ + N+RP Sbjct: 62 PRETIQSIHHNKLALKGPLTTPT----GGGYRSVNVQLRKEFELFANVRPALTL------ 111 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-EHEVVIQESVFTRRGVDRILRYAFEL 177 + G + ++D ++REN +G Y++ + G H V + TR G RI+RYAFE Sbjct: 112 IPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPER 236 A RK +T K+N L + E + +A+ Y I ++++ +D + V+ P R Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLVLDPGR 231 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V +NLFGDILSDL G +G+AP N+ ++FE VHGSAPDI GK IAN Sbjct: 232 FDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIG---KQAAIFEAVHGSAPDIAGKGIAN 288 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE-EVIAHGPKTPDMKGNATTPQVADAI 355 P+A + A AMMLD +G D + AI + G +TPD+ G A T ++ A+ Sbjct: 289 PLALMLAAAMMLDHVGKTDL-----ATRLRNAIRITTLEDGIRTPDLGGTAKTRELTQAL 343 Query: 356 CKIIL 360 I Sbjct: 344 ISRIG 348 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 356 bits (913), Expect = 8e-97, Method: Composition-based stats. Identities = 113/365 (30%), Positives = 173/365 (47%), Gaps = 14/365 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K +A + GDGIG E++P +++L AA G +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L D G + S R+ F + N+RP + F G Sbjct: 81 TLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG-----GN 135 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 D +VRENTEG Y+ G +V I + TR +RI AF+LA Sbjct: 136 AIVEGTDLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAHEAFQLA 195 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R K +T K+N L ++ + + + + YP++ + HID V + ++FD Sbjct: 196 RTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVRRADKFD 254 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G++GIAPS N + ++ + HGSAPDI G++IANPI Sbjct: 255 VIVTENMFGDILSDLAGEVAGSLGIAPSINSSATH---AMAQASHGSAPDIAGRDIANPI 311 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A I + AM+L +L DE+ +A + + AA++ +A G TPDM G ++ ADA+ Sbjct: 312 AMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDMGGTSSCSGFADAVV 371 Query: 357 KIILR 361 R Sbjct: 372 AATAR 376 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 352 bits (904), Expect = 9e-96, Method: Composition-based stats. Identities = 122/367 (33%), Positives = 184/367 (50%), Gaps = 30/367 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER----WGFALSFEQMEW-ASCEYYSHHGKMMPDD 61 I IP DGIGKEV+P ++V+ AA + S + + A E + GK +P + Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKSLPVE 93 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L + D FG+V P ++ R+ D Y N+RP + Sbjct: 94 TVEALKNKCDGAIFGSVQSPSHKV--EGYSSPIVAMRKLVDLYANIRPCQDL-------- 143 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 ID +VRENTE Y V+ T + + + + T R RI A++LA Sbjct: 144 ---AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEIAYKLAV 200 Query: 180 SRPRK---TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 R + +T KSN L++S + E +++ YP+++ ++Q +D + + ++ P + Sbjct: 201 QRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKMILDPTQ 260 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 +DVVVA NL+GDILSD G A G +G+ SANL+ +L EPVHGSAPDI+GK I+N Sbjct: 261 YDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS---FALVEPVHGSAPDIFGKKISN 317 Query: 297 PIATIWAGAMMLDFLGNGDER---FQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVA 352 PIATI A AM+L L D + + + + A+ V+ TPD+ G T + Sbjct: 318 PIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGNTETLV 377 Query: 353 DAICKII 359 DAI K + Sbjct: 378 DAIIKNL 384 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 101/367 (27%), Positives = 168/367 (45%), Gaps = 35/367 (9%) Query: 1 MMKT-----MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG 55 M + + IPGDGIG V +V++A + FE+ E Sbjct: 30 MPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAM----HAPVHFERYEVLGNMRK---- 81 Query: 56 KMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 +P++ E + R G + P + ++ R+E D + +L PG+ Sbjct: 82 --VPEEVIESVKRNKVCLKGGLATP----VGGGVSSLNMQLRKELDIFASLVNCINVPGL 135 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + ++D V+RENTEGEYS L V G VV V T+ +RI RYAF Sbjct: 136 VT-----RHENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITKFCSERIARYAF 186 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A RK +T+ K+N + ++ + E +A++Y I +++ +D C + V +PE Sbjct: 187 EYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPE 246 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD-IYGKNI 294 +FDV+V NL+G+++++ G G+ P N+ E D + + Sbjct: 247 QFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKK 306 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 ANP+A + + AMML L RF + + A+++VI G +T D+ G+ TT +V D Sbjct: 307 ANPVALLLSSAMMLRHL-----RFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVD 361 Query: 354 AICKIIL 360 A+ + Sbjct: 362 AVIAALE 368 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 67 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 119 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 120 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 175 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 176 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 235 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 236 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 292 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + I + I Sbjct: 293 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIR 346 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 116/381 (30%), Positives = 174/381 (45%), Gaps = 30/381 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M T +I +PGD IG E++ E I+VL + HG + Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQ 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPV-RLFPGV--PC 117 + DA+ FG++G P+ H + LL+ R+ D + NLRP L P + Sbjct: 61 SVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGAS 120 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 P+ F VVREN G Y +V V+TR ++R+ R + + Sbjct: 121 PIREHVVKGTRFIVVRENCGGAYFGEKKEE-----EDVASDLWVYTRPEIERLARVSAAV 175 Query: 178 AQSRPRK-------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ R T+ SA K+N LA + + A+ +P+I Q D + Sbjct: 176 ARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSMAMLM 235 Query: 231 VMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGS 285 V P RF+ V+ N FGDILSD+ A TGT+G+ PSA+L ++EPVHGS Sbjct: 236 VRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGS 295 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG------PKT 339 APDI GK +ANP+A I + AMML + ++ + A+ +V+ +T Sbjct: 296 APDISGKGLANPVAQILSVAMMLRY----SMGLEKEATAVERAVVKVLDAKSEGGLEIRT 351 Query: 340 PDMKGNATTPQVADAICKIIL 360 D+ G AT QV DA+C+++ Sbjct: 352 GDLGGRATCSQVGDAVCEVLG 372 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 108/370 (29%), Positives = 171/370 (46%), Gaps = 18/370 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +I +PGDGIG EV+ E +V+ ++ + A Y HG + D+ Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDE-DLAGGCSYDKHGTPITDEV 63 Query: 63 HEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 + + + GAVG P +LLK R+E + NLRP F + Sbjct: 64 FYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDAST 123 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + I +T + R+ + AF+L Sbjct: 124 LKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFDL 183 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R +TS KSN + + +E E + Y ++ D + + P++F Sbjct: 184 ARKRS-NRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQF 242 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKNI 294 DV+V NLFGD+LSD TG++G+ PSA+L + +++EP+HGSAPDI GK I Sbjct: 243 DVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEI 302 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQ 350 ANPIA+I + AM L + + + A+++V+ G +T D+ K +T Sbjct: 303 ANPIASILSFAMALRY----SLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSA 358 Query: 351 VADAICKIIL 360 + DAI + Sbjct: 359 MGDAIISKLQ 368 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 351 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 114/364 (31%), Positives = 186/364 (51%), Gaps = 12/364 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMP 59 M ++ + + GDGIG EV + +R+L+ G ++ EY G+ +P Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEY-QRSGEALP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ DA+ GA+G P+ + L R Y +RP+RL+ PL Sbjct: 60 QSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPL 119 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G PG+IDF +VRE+TEG + + + TR +R+ R AFE A+ Sbjct: 120 KGHGPGEIDFVLVRESTEGLFYGRDAIADLEADE--ATNLLRITRSASERVCRLAFETAR 177 Query: 180 SR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +KT+T K+N L SM Y+ + +A+ + +I+ + ++D V +P+ FD Sbjct: 178 RRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFD 236 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APS ++ + ++F+P HGSAPDI G++IANPI Sbjct: 237 VMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDDA---AVFQPSHGSAPDIAGQSIANPI 293 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICK 357 A + AMML++L + + R +V++ +T DM GN +T ++ D I + Sbjct: 294 AMHLSTAMMLEWLDHPETRRAADALNAAI--ADVLSDPTQRTADMGGNLSTVEITDKIAE 351 Query: 358 IILR 361 + + Sbjct: 352 RLSK 355 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 351 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 97/363 (26%), Positives = 161/363 (44%), Gaps = 33/363 (9%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++ GDG+G E++ + ++ A G + + +E Y + D E Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L R + + P + + R++ + N+RP + Q Sbjct: 58 TLKRNKVLLKAPITTPR----GGGVRSLNVTLRKKLGLFANIRPCKS-------HLEWQD 106 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D ++REN E YS + R T + V T +RI RYAFE A+S RK Sbjct: 107 PKMDIVIIRENEEDLYSGIEYRQTLDTYN----CTKVITESTSERICRYAFEYARSNGRK 162 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K N + ++ + + + +A YP+I + IDI AR PE+FDV+V N Sbjct: 163 KVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLN 222 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDI+SD+ +G++G+ S N+ E ++FE VHGSAPDI ++IANP + A Sbjct: 223 LYGDIISDIAAEISGSVGLGGSINIGEEY---AMFEAVHGSAPDIADQDIANPSGLLNAA 279 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKI 358 ML ++G ++ + +A + + G T D+ T + + I Sbjct: 280 MYMLSYIGQ-----KEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHN 334 Query: 359 ILR 361 I R Sbjct: 335 IDR 337 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 101/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 104 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 105 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 157 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 213 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 214 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 273 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 274 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 330 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + + + I Sbjct: 331 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIR 384 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 168/359 (46%), Gaps = 27/359 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM--PDDWH 63 + IPGDGIG E++ + + G + FE++ + + + ++ Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFRHI----GVPVDFEELNLSGLD-IKDEDSYLGAFNEAI 106 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P L+ R D + N+ + PG+ + Sbjct: 107 TSIKRNGVAMKGNIFTPLDAIP--GFRSLNLELRVHLDLFANIVRCKSIPGIQT-----R 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++R+NTEGEYS L G V+ V T +I +YAF+ A+ R Sbjct: 160 HNNVDLVIIRQNTEGEYSHLEHENVSG----VIENLKVTTEEACMKIAQYAFDFAEKHDR 215 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + E M+ +YP I ++ ID C + V P++FDV+V Sbjct: 216 KKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLP 275 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+S++G + G GI P N+ + ++FE + DI GK+I+NPI+ ++ Sbjct: 276 NLYGNIVSNIGASLVGGPGIVPGENIGGDY---AIFESGSRHTGLDIQGKDISNPISMLF 332 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 A +ML+ L F + I +AI +V+ G T D+ G+ TT Q A+ + + Sbjct: 333 ASTLMLEHL-----EFTAYADLINSAILKVVQRGVLTADVGGSHTTTQFLSALKSELDQ 386 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 348 bits (894), Expect = 2e-94, Method: Composition-based stats. Identities = 111/372 (29%), Positives = 176/372 (47%), Gaps = 19/372 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T ++ +PGDGIG EV+ E R++ + + E Y + D Sbjct: 1 MATHKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGG-AAYDADKVAITDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 DA+ FGAVG P P LL+ R++ + NLRP +P + Sbjct: 60 TMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + + G + I V+ ++RI R AF+ Sbjct: 120 SLKPEVVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R R +TS K N + + + + + A Y +++ + Q D V P++ Sbjct: 180 LARKR-RNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +++EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATT 348 +ANP+A + + M L + + + + AI V+A G +T D+K +T Sbjct: 299 GLANPVAMLASFGMALRY----SLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVST 354 Query: 349 PQVADAICKIIL 360 Q+ +AI + + Sbjct: 355 SQMGEAIVQEMQ 366 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 103/360 (28%), Positives = 160/360 (44%), Gaps = 28/360 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCE-YYSHHGKMMPDDW 62 + IPGDGIG+E + + A + FE+++ E G + + Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDVTGMEKNNKSSGDAL-HEA 74 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L R G + P H S + R+E D Y +L ++ PG Sbjct: 75 IQSLKRNKVGLKGILFTPFEKGGHTSF---NVALRKELDIYASLVLIKNIPGFKT----- 126 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + ++DF ++RENTEGEYS L + G VV + T RI ++AF+ A Sbjct: 127 RHDNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKIITEYKSKRIAQFAFDFALQNG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK++T K+N + ++ + +A Y I +D + V +P++FDV+V Sbjct: 183 RKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVM 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 NL+G ILS++G A G G+ P AN + +LFEP I G+ ANP A I Sbjct: 243 PNLYGSILSNIGSALVGGPGVIPGANFGRDY---ALFEPGCRHVGLSITGRGEANPTAAI 299 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + +ML LG + + I AA VI G T D+ G+A+T AI + + Sbjct: 300 LSACLMLRHLG-----LKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 109/372 (29%), Positives = 177/372 (47%), Gaps = 18/372 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ +PGDGIG EV+ + R++ + + Y HG P + Sbjct: 1 MAAKKLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGG-AAYDVHGTPYPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E DA+ GAVG P P LL R++ + NLRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y ++ V+T + RI R AF+ Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R K L S K+N L ++ + +E ++ E +P++ ++D + V P++ Sbjct: 180 LARKRN-KKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V N+FGDILSD TG++G+ PSA+L + +L+EPVHGSAPDI GK+ Sbjct: 239 FDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKD 298 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 +ANP+ATI + AM L + + I A++ V+ G +T D+ K +T Sbjct: 299 MANPLATIMSFAMCLRY----SFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTT 354 Query: 350 QVADAICKIILR 361 + +A+ + + + Sbjct: 355 VMGEAVVRELDK 366 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 347 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 138/367 (37%), Positives = 190/367 (51%), Gaps = 19/367 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA +PGDGIG EV +RVL A F + F + A E + G P+ Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALGTS-FPIEFRDYD-AGAECFRRTGTAFPEATQV 70 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGS--LLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A+ GA G PD + + G +K R D Y N+RP+RL G P L GK Sbjct: 71 ACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ--- 179 P DI F +VRENTEG Y++ GG ++ V TR GV+RI+RYA ELA+ Sbjct: 131 GPDDIRFTIVRENTEGLYAARGG--GNIIRGQIATDTLVMTREGVERIVRYAAELARDGQ 188 Query: 180 ---SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 + + +T K+N L S ++ E + + + P I + +D + + +PE Sbjct: 189 GAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERPEH 247 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V NLFGDILSDLG A G +G+APS + + + F+ HGSAP I GK +AN Sbjct: 248 FDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRDHGY---FQGSHGSAPTIAGKGLAN 304 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 PIA I +GAMMLD+LG + D +A I A V+ G TPD+ G+ +T A Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCAA 364 Query: 354 AICKIIL 360 IC + Sbjct: 365 EICATLG 371 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 117/371 (31%), Positives = 168/371 (45%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E I+VL+A A F Q H + D Sbjct: 1 MATHNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 + DA+ GA+G P+ + LLK R+E Y NLRP Sbjct: 61 EALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + DF VVRE T G Y E ++R + RI R A Sbjct: 121 SPLKAEVCRGTDFIVVRELTGGIYFG---DRTEDDGSGYACDTEPYSRAEIVRIARLAGF 177 Query: 177 LAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA P + S K+N LA S + + +++ +P+++ + Q ID V P Sbjct: 178 LALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIY 290 + VV+ SNLFGDI+SD G+IG+ PSA+L + ++EP+HGSAPDI Sbjct: 238 ALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDIS 297 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP+ TI + AMML + + + + AA++ I +G KT D+ GNATT Sbjct: 298 GKGIVNPVGTILSVAMMLRY----SLNLPKEADAVEAAVKAAIDNGTKTKDLGGNATTSD 353 Query: 351 VADAICKIILR 361 + +A+ + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 108/370 (29%), Positives = 172/370 (46%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG E + E +++ E ++ C Y HG + + Sbjct: 1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAY-DAHGAAISEA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC-- 117 ++ DA+ FGAVG P P + LL+ R++ + NLRP +P + Sbjct: 60 DMQKALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 +A++R + S K N + + + E Y +++ + D + V QP++ Sbjct: 180 MARTRQ-NRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + + AI V+ G +T D+ T Sbjct: 299 GIANPIAMIASFAMCLRY----SFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGT 354 Query: 349 PQVADAICKI 358 ++ +AI Sbjct: 355 VEMGEAILAE 364 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 147/362 (40%), Positives = 202/362 (55%), Gaps = 14/362 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M +T+ +A +PGDGIG EV+ E +RVL+ A +L Q + ++ G+++ D Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVP-ADVSLDTTQYPF-GAGHFLETGQILTD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHIS---LWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 L++ DAI GAVG G LLK R FD Y+NLRP L PGV Sbjct: 59 SDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVAS 118 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PLA PG +DF VVRE TEG Y+ GG + GTEHE+ + SV T GV+R +R+AFEL Sbjct: 119 PLAA--PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAFEL 176 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R RK +T K+N L + W V+ +A +P++ D H+D V P RF Sbjct: 177 AEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPSRF 236 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V+ NLFGDI++DL A +G IG+A S N+NP FPS+FEPVHGSAPDI G+ A+P Sbjct: 237 DVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADP 296 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 A I + A++LD LG + + + T D +T +V DAI + Sbjct: 297 TAAILSVALLLDHLGLSEAAARVSAAVSDDLAARA------TGD-AAPRSTAEVGDAILR 349 Query: 358 II 359 + Sbjct: 350 AL 351 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 104/366 (28%), Positives = 169/366 (46%), Gaps = 32/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +A GDG+G E++ + +L+ A +S E ++ +Y + Sbjct: 6 MSVPITVAY--GDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAP 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E +SR + P + R+ YVN+RP + P+ Sbjct: 60 SAWESISRTRLLLKAPTMTPQ----GSGHKSLNVALRQRLGLYVNVRPCVSY----FPVV 111 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + D+D ++REN E YS + +++E T V + TR ++I YAF A++ Sbjct: 112 GTKHPDLDVVIIRENEEDTYSGVEHKLSEDTHECV----KISTRSASEKICAYAFNYARA 167 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T K N + ++ + +A+ YP+I + +D+ A+ PE FDVV Sbjct: 168 HNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVV 227 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NL+GDI+SD+ +G+IG+ SAN+ ++FE VHGSAPDI GKN+ANP Sbjct: 228 VTTNLYGDIVSDIVSLSSGSIGLTGSANIGDYY---AMFEAVHGSAPDIAGKNVANPSGL 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK------GNATTPQVADA 354 + A ML +G D+ I A + + G T D+ A+T + A A Sbjct: 285 LNAAVQMLVHIGQLDK-----AGVIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQA 339 Query: 355 ICKIIL 360 I + Sbjct: 340 IVGNLG 345 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 344 bits (883), Expect = 2e-93, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 175/374 (46%), Gaps = 20/374 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +I + GDGIG EV+ + RV+ + A E Y G + D Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGG-AAYDAQGTPLHD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 D DA+ GAVG P P + LL+ R++ + + NLRP +F + Sbjct: 60 DTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAE 119 Query: 117 -CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYA 174 L + +D +VRE T G Y ++ + V+ + R+ + A Sbjct: 120 ASTLKTELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKVA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LA R K L S K+N + S W E V + +YPEI + D + V QP Sbjct: 180 FDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 ++FDV+V NLFGDILSD TG++G+ PSA+L +++EPVHGSAPDI G Sbjct: 238 KQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM---KGNA-T 347 ++ ANP+ATI + +MML + + + + A+ V+A G +T D+ Sbjct: 298 QDKANPLATILSFSMMLRY----SFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVG 353 Query: 348 TPQVADAICKIILR 361 T + DA+ + + Sbjct: 354 TTGMGDALLAEMAQ 367 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 126/350 (36%), Positives = 171/350 (48%), Gaps = 15/350 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + R+ +PGDGIG EV+ RV AAA R+G L +E+ G + Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRI-GAAAIREEGAPVSK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + + DA+ GAVG P+ + LL RRE + NLRPV P + P Sbjct: 60 ETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D +VRE T G Y E SV+TR V+R+ R AFE A Sbjct: 120 LRPGVAEGVDLLIVRELTGGAYFGEK-----EEGEERASDLSVYTRGEVERVARVAFEAA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R + S K+N LA S W V +A +YP++ + +D V P RFD Sbjct: 175 RGR-RGRVASVDKANVLATSR-LWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRFD 232 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ NLFGDILSD G++G+ PSA+L + P +FEPVHGSAPDI GK +ANP Sbjct: 233 VILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGS-PGIFEPVHGSAPDIAGKGVANPY 291 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 A I + AMM +A I +E +A G TPD+ G++ T Sbjct: 292 AAILSAAMMFRH----GLGRPEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 97/359 (27%), Positives = 160/359 (44%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +A + GDG+G E+L V Q G + FE++ D Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEV-----AVNQESEDATFTDAL 118 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + R + Y ++ R FPGV + Sbjct: 119 LAMKRNGVGIKGNFAT------EPGQSSRNVALRLNLNLYAFVQRCRNFPGVVT-----R 167 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS L G VV + TR RI ++AF+ A R Sbjct: 168 HQNVDIVIIRENTEGEYSRLEHENVPG----VVESLKIITREKSTRIAQFAFDYAVRHNR 223 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + ++A+NYP+I ++ ID C + V +P++FDV+V Sbjct: 224 KKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFDVIVLP 283 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ NL P+ +LFE S + GKNIANP + Sbjct: 284 NLYGNIVGNVAAGLVGGAGLTTGINLGPQ---NALFEMGTRNSGRSLAGKNIANPCGMLL 340 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A ML++LG+ + I ++ +VI +T D+ G+ T +V +A+ K + Sbjct: 341 TSADMLEYLGHI-----KEAKLIRDSVVDVIGEQKIRTADLGGSFKTSKVIEAVLKSLR 394 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 112/366 (30%), Positives = 173/366 (47%), Gaps = 16/366 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA +PGDGIG E++ + VL+ ER G +Y G D+ Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAFSDENM 65 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + DA+ GA+G P + + L R E D Y LRP+R +P +P L K+ Sbjct: 66 AACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDKR 125 Query: 124 PGDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID +VRE TEG YS + V + + +R G R+ +AF +A+ R Sbjct: 126 ASQIDLVLVREQTEGILYS---RCRGTIEDDRVAWETMMISRNGTSRVSEFAFRVAERRA 182 Query: 183 R-----KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + + +SN L SM ++ +AE +P + D ++D + V P F Sbjct: 183 KSRRRPGKVLCVDRSNAL-TSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKSPWEF 241 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V N FG ILSDL G++G+APSA++ + ++F+P HGSAP I G+ +ANP Sbjct: 242 DVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEKH---AVFQPAHGSAPHIAGQGLANP 298 Query: 298 IATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 +A I + A+MLD+L +G+ R + A+E+ + + G T + AI Sbjct: 299 VAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALTV-VCPVEFGGKDGTAAITKAI 357 Query: 356 CKIILR 361 I + Sbjct: 358 IAQIRK 363 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 108/382 (28%), Positives = 167/382 (43%), Gaps = 27/382 (7%) Query: 1 MMKT-MRIAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMM 58 M K +I +PGDGIG EV+ E RVL+ A + E ++ C HG+ + Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCS-IDKHGEPL 59 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVP-DHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 E DAI GA+G P + +LL R+ Y N+RP Sbjct: 60 TAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLL 119 Query: 117 --CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL +D V+RE G Y + + + +++ V RI R Sbjct: 120 AYSPLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSR 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 ++A P + S K+N LA S + E + +P+++ D +D V P Sbjct: 180 RQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANP 239 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP----------SLFEPVH 283 ++ + V++ NLFGDILSD G++G+ PSA+L +P ++EP+H Sbjct: 240 KKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIH 299 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV-----IAHGPK 338 GSAPDI G+ IANPI TI + AM L ++ I AA+E G + Sbjct: 300 GSAPDIAGQGIANPIGTILSAAM----LCGTRSVWRSPAKAIEAAVEGARRQGDRREGLR 355 Query: 339 TPDMKGNATTPQVADAICKIIL 360 T D+ G++ T + + +I+ Sbjct: 356 TADLGGSSKTKDIGHKVVEILK 377 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 120/346 (34%), Positives = 177/346 (51%), Gaps = 9/346 (2%) Query: 17 KEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL-SRFDAIYFG 75 V+ E +L+ ER G + +++ + Y G P+ + A+ G Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDL-GADRYLRDGTTFPNQIQIAIQRECSAVLLG 77 Query: 76 AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVREN 135 A+G P VP+ L R +D Y N+RPVR PL G+ DIDF V REN Sbjct: 78 ALGDPR-VPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFREN 136 Query: 136 TEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 TEG Y +GG+ GT EV I E V TR+GV+RI+R AF+ A++ R +T A KSN + Sbjct: 137 TEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMADKSNAM 196 Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 + W + YPEI+ + ++D LC + P +F V+V +NLFGDI++DLG Sbjct: 197 RHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGA 256 Query: 256 ACTGTIGIAPSANLNP-ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNG 314 A G +G+A SAN++ + +LFEPVHGSAP + GK+IANP A + ++L LG Sbjct: 257 ALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLG-- 314 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + I + + + G T D+ G T + + I Sbjct: 315 ---WPEEERRIERWVSQALDQGMCTVDVGGTLGTRAAGAWVREQIA 357 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 121/365 (33%), Positives = 182/365 (49%), Gaps = 27/365 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + ++ +PGDGIG EV+ + +L+A AE G +++ Y H + P+D Sbjct: 8 DSYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDA 67 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHI--------SLWGSLLKFRREFDQYVNLRPVRLFPG 114 + D I GAVGWP + +++ R + D Y N+RPV+L PG Sbjct: 68 EARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPG 127 Query: 115 VPCPLAG-----KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDR 169 V ++G +P +D ++RENTEG Y+ +GG++ G V + TRRG +R Sbjct: 128 VAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCER 187 Query: 170 ILRYAFELAQSRPR-------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQH 222 I+R AFEL + R R K +T K N L + E +A YP+I + Sbjct: 188 IIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVASEYPDIANELAI 246 Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV 282 +D V QPE +DV V +NLFGDI++DL G +G+A N+ E ++FEP+ Sbjct: 247 VDAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEH---AMFEPI 303 Query: 283 HGSAPDIYGKNIANPIATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKT 339 HGSAP + GK+ ANP+A + A L +LG D R + + + A+ V G P T Sbjct: 304 HGSAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLT 363 Query: 340 PDMKG 344 D+ G Sbjct: 364 VDLVG 368 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 176/366 (48%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IA + GDGIG E+ +G+ V+ A E++G +++E + G P++ + Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYA-ICGADAIDKVGDPFPEETYR 61 Query: 65 QLSRFDAIYFGAVGWPDTVPDHI---SLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPL 119 DA+ F AVG P D LL R++ + N+RPV+ F + PL Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + DF +RE T G Y + +++ +++TR ++RIL+ FE A Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQ-----DNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RK LT K+N LA S W + + MA YPE+ D +D + + +P+ FDV Sbjct: 177 KR-RKHLTVVDKANVLASSR-LWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDV 234 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N FGDIL+D G +G++G+ PSA+ +FEP+HGS P G NIANP+A Sbjct: 235 MVTENTFGDILTDEGSVISGSMGLLPSASTGES---TPVFEPIHGSWPQAKGLNIANPLA 291 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADAI 355 I + AM+ ++ + I A++ + +TP++ T +V I Sbjct: 292 QILSVAMLFEYF-----DCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWI 346 Query: 356 CKIILR 361 I + Sbjct: 347 VDYIRK 352 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 103/359 (28%), Positives = 166/359 (46%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+ VL + G + FE ++ + D Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVLH----KCGAPIDFEVIDI--------KDESSTDAAI 134 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 L R G + + P + RR+ D Y N+ P + PGV + Sbjct: 135 ISLKRNGIGLKGTITTNISNPQSQ---SINAQIRRKLDLYSNIVPCKSIPGV-----WTR 186 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G +D V+RENTEGEY SL +G VV + T + RI ++AF+ A R Sbjct: 187 HGQVDLVVIRENTEGEYGSLEHENVDG----VVESLKIITEKKSRRIAKFAFDYALQNNR 242 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 + +T+ K+N + ++ + E ++++Y +I ++ ID C + V P++FDV+V Sbjct: 243 RKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFDVMVMP 302 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+S +G G IG+ P N+ + ++FE D+ G N ANP ++ Sbjct: 303 NLYGNIVSHIGIGLVGGIGLVPGKNIGDKY---AIFESGARNIGSDLVGLNRANPCGFLF 359 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A+ML LG + I +A+ I +G +TPD++G+ TT DA+ K I Sbjct: 360 TSALMLRHLG-----LDDYADIIESAVRTTIKNGKCRTPDIQGDRTTADFIDAVIKEID 413 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 110/356 (30%), Positives = 168/356 (47%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRIA I GDG+G E++ + +L+ + A Y+ GK + D+ E Sbjct: 1 MRIAVIKGDGVGPEIMGATLSLLERYIGADFIEIK------AGKSYFIEEGKPIEDNAIE 54 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D++ G V P P + RREF Y N+RP R + G+ Sbjct: 55 KIRECDSLLKGPVATPTKGPSYP---SVNTLLRREFKLYANVRPFRSYEGIS-------I 104 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID +VREN E Y + + I V T+RG +RI +AF LA+ R Sbjct: 105 RRIDTILVRENLECLYYGWEVE-----DEDRAIAMRVITKRGAERISEFAFNLAKREGRG 159 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K N L + + + +A + ++R D + +D + V FDV++ N Sbjct: 160 RVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVMLTPN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSD+ G+IG+ SA + + + FEP+HG+ DI GK +ANPI I A Sbjct: 219 LYGDILSDVAAGVVGSIGLCGSAQIGED---FAAFEPIHGTGEDIAGKGVANPIGMIIAA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +MMLD+L R + I A++ VI TPD+ G+ T QV + I + Sbjct: 276 SMMLDWLWERG-RSPKRGEKIREAVDSVIRDRILTPDLGGDFRTEQVVEKIVDRLR 330 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 339 bits (870), Expect = 1e-91, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 159/359 (44%), Gaps = 32/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDG+GKE+ + +A + +E + ++ + Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINIKQTDHKEGV-----YEAV 78 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E L R G P D + R++ D Y N+ + GV + Sbjct: 79 ESLKRNKIGLKGLWHTPA---DQTGHGSLNVALRKQLDIYANVALFKSLKGVKT-----R 130 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID V+RENTEGE+S L G VV V TR +RI R+AF+ A+ R Sbjct: 131 IPDIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRPKTERIARFAFDFAKKYNR 186 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K++T+ K+N + + + + + + YP+I +D + V +P +FDV+V Sbjct: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +++G IL ++G A G G+ AN + ++FEP DI G+N+ANP A I Sbjct: 247 PSMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEPGSRHVGLDIKGQNVANPTAMI 303 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + +ML+ LG + I A+ E IA G T D+ G+++T + I + Sbjct: 304 LSSTLMLNHLG-----LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 119/361 (32%), Positives = 174/361 (48%), Gaps = 17/361 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I + GD IG E++PE +RV+QAAA R G A+ ++ + G +PD E Sbjct: 1 MKIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPI-GRAALDSLGSTLPDGTIE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L D G +G P R+ FD + N+RPV+ +PC Sbjct: 60 RLDALDGWLLGPIGH-MAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL-----H 113 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D +VREN EG G +V I V TR G ++ R AFELA++R Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFELARAR 173 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ LT+ K + + E +A YP++ +D+ +D R VM P+R+DVVV Sbjct: 174 -RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYDVVV 232 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDIL+D G +G+A P ++ + HGSAPDI G+ IANP A I Sbjct: 233 TTNMFGDILTDEAAGLVGGLGMAAGLCAGPRH---AMAQATHGSAPDIAGRGIANPYAMI 289 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKI 358 +G M+LD+LG A I A+ +I TPD+ G TT + AI + Sbjct: 290 MSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQGTTAGMGSAIIEA 349 Query: 359 I 359 + Sbjct: 350 M 350 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 95/360 (26%), Positives = 160/360 (44%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PGDGIG E+L ++ A + FE+ + S D+ Sbjct: 44 RHTVTLLPGDGIGPEMLDIVQKIFTFA----NVPVDFEECQLDSKPTSPESDL---DNAI 96 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P ++ RR D + N+ P +P + Sbjct: 97 MSIQRNGVAIKGNIETKYDDP---IFKSRNVELRRRLDLFANVLHCVSIPTIPT-----R 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 I+ ++RENTEGEYS G VV + TR ++RI R+AF+ A + R Sbjct: 149 HKGINIVMIRENTEGEYSGHEHETVNG----VVESLKICTREKLERISRFAFDYAIAHNR 204 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K +T+ K+N ++ + + V +A + YP I +D +D + V +P++FD+++ Sbjct: 205 KKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQFDIMLM 264 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATI 301 NL+G+I+S++ G G+ N+ + ++FE + I G++IANP A I Sbjct: 265 PNLYGNIISNIACGLVGGPGLVSGMNIGDKY---AVFETGTRNTGSGIAGQDIANPTAFI 321 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 AG ML +LG + N I A+ + I T D+ G A T V +A+ + I Sbjct: 322 RAGVDMLHYLG-----LTEYANLISDALFDAIVIKRLHTKDIGGTAKTSDVVNAVMRNIE 376 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 108/411 (26%), Positives = 167/411 (40%), Gaps = 66/411 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM--MP 59 I I GDGIGK+V P +VL+AAAE G +S+ ++ A +G+ +P Sbjct: 28 PDNPIIPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRVY-AGESAREEYGEDVNLP 86 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D+ + + G + P + R+ D Y N+RP GVP P+ Sbjct: 87 DETVDAIREHRVAIKGPLTTP----VGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPM 142 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 P ++D RENTE Y+ + +V I Sbjct: 143 KA--PEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLK 200 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE---- 215 T +G R++R A + A R +T K N + + + + +A E YP+ Sbjct: 201 PITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVF 260 Query: 216 -------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + +++ D + ++ + FD++ NL GD LSD A Sbjct: 261 AAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLSDAAGA 320 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G +GIAP N L EPVHGSAP G+++ANP A I +G +M D+LG Sbjct: 321 QIGGLGIAPGGNFG---KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDYLG---- 373 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + A + I A+EE I+ G T D++ T + D I I + Sbjct: 374 -WDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 336 bits (863), Expect = 6e-91, Method: Composition-based stats. Identities = 94/360 (26%), Positives = 158/360 (43%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PG GIG E++ +A + FE + + M D Sbjct: 47 RFFVTLLPGHGIGPEMMRHV----EAIFACGKVPVDFETIIV---DANVGDASSM-DHAI 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + + R G + +++ L R + + YVN+ R PG+ + Sbjct: 99 KSIRRNGVALKGNIETTSY---SMTVEPRNLLLRNKLELYVNVVHCRNHPGI-----NTK 150 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D V+R+NTEGEYS L V G VV + T +I +Y FE A++ R Sbjct: 151 HKGVDIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYCFEYARTHMR 206 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T K+N + ++ + + +A+ YP+I + ID C + V P +FDV++ Sbjct: 207 KKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDVMLVP 266 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ N E ++FE + + GKN+ANP+AT++ Sbjct: 267 NLYGNIVVNVACGLVGGAGVTSGRNYGKEY---AVFETATRNTGTPLVGKNLANPVATLY 323 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIILR 361 A ML L I AIE+ + T D+ G+ATT +V + I K + + Sbjct: 324 AAVDMLKHL-----ELWDHAVVIRRAIEKTVNRDKVHTKDLGGDATTSKVVENILKEVQK 378 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 108/381 (28%), Positives = 163/381 (42%), Gaps = 36/381 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+T + +PGDG G E++ VL AA GF + ++ + A + ++PD Sbjct: 1 MRTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWD-VHQAGQRALAESESLLPDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + A G P + R+E D Y LRPVR P + Sbjct: 60 TLNSIRTNGAALKGPTTTPI----GTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEE 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLG---------------GRVNEGTEHEVVIQESVFTRRG 166 + +D VVRENTE Y+ L G + + + FT G Sbjct: 115 PERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPFTPHG 174 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +R++ +AF A RK + S + + + +A +P I + L Sbjct: 175 CERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVPVPAL 234 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 CA V P R DV+V NL+GDI+SD+ A G++G+AP AN+ ++FE HGSA Sbjct: 235 CADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAHH---AVFEATHGSA 291 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDM--- 342 P+ G NP A I++G M+LD LG + I AA+E+V+A G T D+ Sbjct: 292 PEFAGSGRLNPTALIFSGCMLLDHLGEHET-----AARIRAAVEDVVAAGEVLTFDLLAP 346 Query: 343 ---KGNATTPQVADAICKIIL 360 ATT + A+ + Sbjct: 347 QRSADAATTVEFTRAVTDRLG 367 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 117/356 (32%), Positives = 173/356 (48%), Gaps = 31/356 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA IPGDG+G E++ I VL+ ++ L E A E G +P++ Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFE-AGDETKRKRGVALPEETLN 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA A+G S +L R++ D YVNLRP + +P + Sbjct: 61 GVMNSDATLMVAIG--------ESAREVILPLRQKLDLYVNLRPAKSYP------VPRAI 106 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VRENTE Y G R + + + TRR +RI R+ + A+ R + Sbjct: 107 PGFDLTIVRENTEDLYVMSGWR-----GLDTAVDLRIITRRASERICRFGYRYARERGKS 161 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 + K+N L M + E +AE + + ++D R M FDV++ +N Sbjct: 162 RVYVVHKANVLGGCM-LFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVIITTN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDILSDL A G +G+ PSAN+ R ++FEPVHG+AP+I GKNIANP+ATI + Sbjct: 219 MFGDILSDLAAAFIGGLGMYPSANIGESR---AIFEPVHGTAPEIAGKNIANPMATILSA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMM+ +LG+ I A+ G TPD+ G+ T +V I +I+ Sbjct: 276 AMMMGWLGHEGG-----SKLIEEAVRRACELGYTTPDVGGSMRTKEVGLKISEIMR 326 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 125/356 (35%), Positives = 172/356 (48%), Gaps = 15/356 (4%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA IPGDGIG EV+ + VL A G + ++ + + Y G+ + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDAL----GLGTRTDILDHVNADTYLRTGEALTGSDLDR 76 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + +A GAVG P + D + G L R E D YVN RP RL+ PL Sbjct: 77 IRSSEAALLGAVGDPR-LGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARR 135 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ID +VRENTEG YS +GG GT E+ + + TR GV R+L +AF A+ + Sbjct: 136 AIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAARR----S 191 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N + W +P I ++D R P FDV+V +N Sbjct: 192 VCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNS 251 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL A G +G+A SANLNP T +LFEPVHGSAPDI G ANP I + A Sbjct: 252 YGDILSDLTAALAGGLGVAASANLNP-VTGRALFEPVHGSAPDIAGSGTANPFGAILSVA 310 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 ++ + LG +E +A G TPD+ G T +V A+ + R Sbjct: 311 LLAEHLGRNEEADAVRRAV-----AAAVAAGRVTPDLGGPLGTKEVGAAVLAELRR 361 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 129/384 (33%), Positives = 190/384 (49%), Gaps = 42/384 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ RI IPGDGIG EV + ++V++AA +GF+L + E+Y +++PD Sbjct: 1 MKSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPY-GAEHYLSTRQVLPDH 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E++ DA+ GA+G P P + G LLK R FDQY N+RPVR F P PL Sbjct: 60 ALEEMEGLDALLLGAIGDPRVQPGIL-ERGILLKLRFHFDQYANIRPVRSF--TPGPL-- 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG----------RVNEGT-------------EHEVVIQ 158 G ++ V+RENTE Y +G V G +Q Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T G R +YAF+LA + +T ATKSN + ++ +A Y + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++D LC + V P F V++ N+FGDI+SDL G +G+APS N+ S+ Sbjct: 232 RVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDR---LSM 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 FEPVHGSAPDI G++ ANP+A+I +GAM+L LG A + A++ ++ Sbjct: 289 FEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETS-----AAKAMEDAVQRYLSGPVE 343 Query: 338 -KTPDMKGNATTPQVADAICKIIL 360 +M G T DA+ + + Sbjct: 344 ELPIEMGGRLGTRGAGDAVVRRLE 367 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 331 bits (850), Expect = 2e-89, Method: Composition-based stats. Identities = 109/409 (26%), Positives = 169/409 (41%), Gaps = 64/409 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + + I GDGIGK+V P +VL+AAA G +S+ ++ +A + + +PDD Sbjct: 30 PENPIVPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRV-FAGESAREKYDENLPDD 88 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + G + P + R+ D Y N+RP GVP P+ Sbjct: 89 TVNAIDEHRVAIKGPLTTP----VGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKA 144 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVF 162 P ++D RENTE Y+ + +V I Sbjct: 145 --PEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPI 202 Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE------ 215 T G R++R A + A R +T K N + + + E +A E YP+ Sbjct: 203 TEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVFAA 262 Query: 216 -----------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + + + D + ++ + F V+ NL GD LSD A Sbjct: 263 PDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSDAAGAQI 322 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +GIAP AN R L EPVHGSAP G+N+ANP A I +G +M D++G + Sbjct: 323 GGLGIAPGANFGDAR---VLAEPVHGSAPKRAGQNMANPTAMILSGRLMFDYMG-----W 374 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + A + + A+EE I+ G T D++ T + +DAI + I + Sbjct: 375 KDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 331 bits (849), Expect = 3e-89, Method: Composition-based stats. Identities = 112/360 (31%), Positives = 173/360 (48%), Gaps = 15/360 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I +PGDGIG E++ +RVL+AA++R+ L + A HG + E Sbjct: 1 MKIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEI-GHDIAGHASLQRHGATVTPALLE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D + G + D + FR+E D Y N+RP R FPG+ + Sbjct: 60 KVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAH-----RV 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G+ + VVRENTEG Y+ + VI TR +RI R AF+LA++R Sbjct: 115 GEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDLARTR 174 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R ++ K+N L I + + +A +P++R D +D + A V P+RFDV+V Sbjct: 175 AR-HVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFDVIV 233 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDILSDL +G++G+ S N + ++ + VHGSAPDI G+NIANP + I Sbjct: 234 TTNMFGDILSDLTAELSGSLGLGGSLNAGKDH---AMGQAVHGSAPDIAGRNIANPYSLI 290 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + +L + G F A I + T D G T + + + + Sbjct: 291 LSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRDAGGELGTAEAGQSFVRRL 350 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 165/366 (45%), Gaps = 31/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI + G+GIG E+ IRV++A G ++ + A E +G +P + Sbjct: 1 MRIGVLKGNGIGPEITAATIRVIEA----TGIQPEWDFIPIA-DEAVRLYGHALPPQVIQ 55 Query: 65 QLSRFDAIYF---------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 ++ G + T ++ RRE + +VN RP+R + G+ Sbjct: 56 RIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGI 115 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +D ++RE TE Y + +G TR ++ +YAF Sbjct: 116 SG-----RHEKMDMVIMREITEDTYIGWEKPLEDGA---AAEAIKRVTRSASWKVSQYAF 167 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+ RK ++ K+N L + + + +A YP+I D ID C V P Sbjct: 168 EYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPC 227 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDVVV N +GDI SDL G++G+AP AN+ S FE HG+APDI G A Sbjct: 228 WFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDSA---STFEAAHGAAPDIAGTGAA 284 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADA 354 NPIA I +GA +L G G + I A+ VI G TPD+ G +TT QVADA Sbjct: 285 NPIALILSGAELLAHAGYG-----KGSEAIREAVTRVIEAGRTLTPDLGGRSTTEQVADA 339 Query: 355 ICKIIL 360 I + Sbjct: 340 ISVEVR 345 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 97/357 (27%), Positives = 159/357 (44%), Gaps = 36/357 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPG GIG E+ V +A + F+ ++ + E DD Q Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL----HVPIKFDVLDNFNFEN---------DDSKSQ 80 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L + + I G + + KF + D Y N+ G+ ++ Sbjct: 81 LRKNECILLGVMTEKNQKYTD------NYKFYKYLDLYSNITFAFSVEGIT-----QRHN 129 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 + D V+RENTEGEYS + V G VV V T++ RI YAFE A R+ Sbjct: 130 NTDIVVIRENTEGEYSGVEHEVYPG----VVESIKVTTKQASLRIAEYAFEFAHLSGRRK 185 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A+ Y I++++ ID C + V P +FDV+V NL Sbjct: 186 VTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVMVMPNL 245 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +G I+ ++ TG +G+A A++ + S + + DI GKN+ NP A + + Sbjct: 246 YGSIVQNVVAGITGGVGMAAGASIGKDHALFS--QGCRHTGRDIAGKNVVNPSAMLVSST 303 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 ++L LG + I A++ I KT D+ GNATT Q + + + R Sbjct: 304 LLLRHLG-----LPNFADQICRAVQHTIQDKKIKTKDIGGNATTDQFTSEVIRSLGR 355 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 108/362 (29%), Positives = 174/362 (48%), Gaps = 13/362 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI +P DGIG E++ + VL++A + L+F+ + +G + D+ Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDV-GFTSLEKYGTTLRDEVLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + +D + G D FR D Y N+RP R P + + + Sbjct: 60 KAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRT 119 Query: 125 GDIDFYVVRENTEGEYSSL---GGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D ++RE TEG Y G ++ I TR +RI R AFELA R Sbjct: 120 --MDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR 177 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 +K +T+ K+N ++ + E V +A ++PE+R D ID A V PERFDV+V Sbjct: 178 -KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 A+N +GDI+SDL +G++G+A S + + HGSAPDI G++ ANP++ I Sbjct: 237 ATNFYGDIISDLASELSGSLGLAGSMMASDTH---CCAQAQHGSAPDIAGQDKANPVSMI 293 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + AM++ ++G + A + AA++ V+ + +TPD+ GN + K+ Sbjct: 294 LSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKV 353 Query: 359 IL 360 I Sbjct: 354 IQ 355 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 329 bits (845), Expect = 7e-89, Method: Composition-based stats. Identities = 106/369 (28%), Positives = 165/369 (44%), Gaps = 34/369 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG+E++ ++A G + +EQM+ E + G + D Sbjct: 32 QAHTVLTFDGDGIGREIVSAAKECIEA----TGVNIRWEQMDM-GYEAMQNTGVYIDDSH 86 Query: 63 HEQLSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 + ++ G + P FR+ F + N+RPVR PGV Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P D+D V+RENTE Y+ V+ T H V +R +R+ ++F+ Sbjct: 147 AP-----FNDVDLVVIRENTEDVYTGEETWVDADTVHCV----KRISRGASERVADFSFK 197 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE--NYPEIRWDKQHIDILCARFVMQP 234 A+ RK +T+ K+N S + A + I D Q D + +++P Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLMIEP 257 Query: 235 ERFDVVVASNLFGDILSDLGP----ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 + FDV+ NL+GD+++ L G++G+ PS N+ T +LFEP HGSAPDI Sbjct: 258 KSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG---THQALFEPAHGSAPDIA 314 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK IANP + I +G MML LG +A + A+ + A G D G A T + Sbjct: 315 GKGIANPTSQILSGCMMLSHLGEF-----EASQRLENALRAMYASGIVPVDFGGQADTKE 369 Query: 351 VADAICKII 359 V A+ K + Sbjct: 370 VVAAVLKHL 378 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 151/353 (42%), Positives = 201/353 (56%), Gaps = 17/353 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A IPGDGIG EV+ EG++VL+A A + + + G+++PD + Sbjct: 1 MRLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDL-GASRWQRTGELLPDTVLD 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L R DAI GA+G P VP I G LL+ R E D +VNLRP RLF GV PLA Sbjct: 56 ELRRHDAILLGAIGDPS-VPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAAPGA 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID VRE TEG Y GG + T HEV + S+ T GV+R++RYAFE A +RPR+ Sbjct: 115 --IDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALARPRR 172 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT K+N L + W VE ++ +PE+ QH+D FV P RFDV+V N Sbjct: 173 HLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVIVTDN 232 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDI++DL A TG IG+A S NL+ T PS+FEPVHGSAPDI GK +A+P AT+ + Sbjct: 233 LFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSV 292 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 ++LD LG D+ + AA+ ++ T D + T V D + Sbjct: 293 GLLLDHLGRADQ-----ARKVNAAVAFDLS----TRDPEAQVRTEDVGDRLAA 336 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 107/419 (25%), Positives = 167/419 (39%), Gaps = 72/419 (17%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG ++ RV+ AA E+ G + A + + G+ +P Sbjct: 16 PNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + + + + G + P + + R+E D + LRPVR F GVP P+ Sbjct: 76 QETLDTIKEYLIAVKGPLTTPI----GGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 +P D+D + RENTE Y+ + + +V I Sbjct: 132 K--RPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDER--------------- 205 ++ G +R++R A + A RK++T K N + + + + Sbjct: 190 PVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFT 249 Query: 206 ------------------VEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFG 247 + AE +I DI + + +P DVV NL G Sbjct: 250 WQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNG 309 Query: 248 DILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMM 307 D +SD A G IGIAP AN+N E T ++FE HG+AP G N NP + I + +M Sbjct: 310 DYISDALAAQVGGIGIAPGANINYE-TGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLM 368 Query: 308 LDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIIL 360 L+ LG +Q+A + I +IE+ IA T D +T AD + K + Sbjct: 369 LEHLG-----WQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK 422 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 326 bits (837), Expect = 6e-88, Method: Composition-based stats. Identities = 92/359 (25%), Positives = 161/359 (44%), Gaps = 29/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ IP DGIG+ ++ + V Q G + FE+ +D Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKS--FNDIK 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + + R + D Y N+ + +P V + Sbjct: 99 TSVLRNGTALKGNWATSMGIDS----KSYNVLLRHDLDLYANVVKFKSYPTVIT-----R 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D V+RENTEGEY++L G V+ + T++ +RI +YAF+ A R Sbjct: 150 HNNVDLIVIRENTEGEYTNLEHENIPG----VIEMIKIITKKKSERIAKYAFDYAMENNR 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + + + +AE YPEI ++ ID + V +PE+FDV+V Sbjct: 206 KKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFDVIVTP 265 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G++LS++ A G G+ N +FE S DI KNIANP++ ++ Sbjct: 266 NLYGNVLSNIAAALVGGPGLPHGENHG---NGIHVFESGTRNSGMDIATKNIANPMSMLF 322 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A +L L + + I + I +++ +T D+ GN +T + + + K + Sbjct: 323 AATALLRHL-----QLSKHAQLIESCIHKIVTTNQARTVDIGGNTSTSEFFEILVKEVE 376 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 103/386 (26%), Positives = 169/386 (43%), Gaps = 49/386 (12%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++IA +PGDGIG EV + V + + + E++ G +P Sbjct: 5 DPIKIAVLPGDGIGIEVTEATLPVFEVL----DVPVILNYGDI-GWEFWKKEGAAIPSRT 59 Query: 63 HEQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVRL 111 + ++ D + GA+ + +++ R+ D + N+RP Sbjct: 60 WQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFS 119 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT---------------EHEVV 156 P +F ++REN+EG Y E Sbjct: 120 IDDQSKP--------FNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEAS 171 Query: 157 IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI 216 + ++ G+ R+ +AF+ A +T A K N L S + + E+ A+ YP+I Sbjct: 172 CALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKI 231 Query: 217 RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP 276 + D ++D + + PE+F V+VA N+FGDILSD+G G +G+APSAN+ + ++ Sbjct: 232 QADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSY- 290 Query: 277 SLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG 336 FEPVHGS P I KN ANP A +M+L+ G D I+ A+ +VI Sbjct: 291 --FEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPDR-----AKKIVNAVMQVIKEK 342 Query: 337 -PKTPDMKGNATTPQVADAICKIILR 361 T D+ G+ATT +A+A+ + R Sbjct: 343 RFITYDLGGHATTTDMANAVIEHCAR 368 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 119/408 (29%), Positives = 178/408 (43%), Gaps = 62/408 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG +VLP+ IRVL+A GF ++ + E + + G +PD Sbjct: 1 MARPTVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADI-GWECWCNEGNALPDR 55 Query: 62 WHEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 + L + FGA+ P+ +S + ++ R+ F+ V +RP Sbjct: 56 TIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCL 115 Query: 111 LFPGVP------CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT------------- 151 FPG P G + +D V R+NTEG Y+ + Sbjct: 116 SFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAA 175 Query: 152 -----EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 E+ + + T++ RI AF+ A+ K +T K N L + +E Sbjct: 176 FANTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVA 235 Query: 207 EAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 + + + YPEI +ID PE + V+VASNLFGD++SD G +G A S Sbjct: 236 KQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAAS 295 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKN--IANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 N+ E ++FEP HGSAP N I NPIA I + AMMLD +G ++ + Sbjct: 296 GNIGDE---VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHIGESEK-----ADR 347 Query: 325 ILAAIEEVIAHGP-KTPDM----KGN-------ATTPQVADAICKIIL 360 I AI +V+ G +T DM G A T Q+ DAI + Sbjct: 348 IRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVE 395 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 101/411 (24%), Positives = 155/411 (37%), Gaps = 65/411 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFA--LSFEQMEWASCEYYSHHGKMMP 59 + I I GDGIG EV I+V A E+ + G +P Sbjct: 42 PDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLP 101 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D E L + + P + R+ FD Y N+RPV+ FPG+P PL Sbjct: 102 DQSIEVLRKIRVFLKAPLETP----VGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPL 157 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFT 163 +P +D + RENTE Y+ + + I + Sbjct: 158 R--RPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPIS 215 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA------------- 210 + G RI R A + A R+ +T K N + + E +A Sbjct: 216 KFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFEDE 275 Query: 211 -ENYPE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 Y + + + D + + + + +DV++A NL GD +SD G +G+ Sbjct: 276 LAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLGV 335 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP ++ + + EPVHG+AP GKN NP ATI A +M FLG +++ Sbjct: 336 APGLDVGD---WGMMAEPVHGTAPKYRGKNYVNPTATILALELMFRFLG-----WREVAE 387 Query: 324 GILAAIEEVIAHGPKTPDMKGNAT-------------TPQVADAICKIILR 361 I+ +E G T D+ T T + AD + +II R Sbjct: 388 YIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIKR 438 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 324 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 102/417 (24%), Positives = 155/417 (37%), Gaps = 70/417 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ V AA ++ G A Y G+ +P Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D L + G + P I + R++ D Y RPV +PG P P+ Sbjct: 76 DKTLATLREYLVGIKGPLTTPI----GIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE-------------------VVIQES 160 P +++ V RENTE Y+ + V+ E Sbjct: 132 VH--PENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE----- 215 +++G R++ A + A + R TLT K N + + + + AE Y + Sbjct: 190 PISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDKVFTW 249 Query: 216 ---------------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGD 248 + + D + ++ PE F+VV NL GD Sbjct: 250 NQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATMNLNGD 309 Query: 249 ILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML 308 +SD A G IGIAP N+N +T ++FE HG+AP G+N NP + I +GAMM Sbjct: 310 YISDALAAQVGGIGIAPGGNIN-YQTGHAIFEATHGTAPQFAGQNKLNPTSIILSGAMMF 368 Query: 309 DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAICKIIL 360 D+LG + N I I+ I T D +T + + ++I Sbjct: 369 DYLG-----WDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIE 420 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 323 bits (829), Expect = 5e-87, Method: Composition-based stats. Identities = 116/387 (29%), Positives = 164/387 (42%), Gaps = 52/387 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M RI +PGDGIG EV+ + V+ A + + + G+ +P Sbjct: 5 MLRKRICVLPGDGIGIEVMEAALPVIAAL----NLPFDLVPADI-GWQCWRAEGETVPAR 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVR 110 E ++ DA GA+ + +++ R+ D Y N+RPV Sbjct: 60 TWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVT 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGR-------------------VNEGT 151 G F V+RENTEG Y+ L Sbjct: 120 DMTG---------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + + + + TR G+ RI YAFE A+ +T K L S + EA A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP++ +++D + V +PERF V+VA N+FGDILSDLG G +G APS N Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 + FEPVHGSAP G N ANP A A A+ML+ LG F I A+ Sbjct: 291 SG---AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLG-----FPTESACISQAVSL 342 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKI 358 V +T D+ G+ TT QV +AI + Sbjct: 343 VSRTSTRTYDLGGSHTTAQVGEAIVQQ 369 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 96/407 (23%), Positives = 163/407 (40%), Gaps = 63/407 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG---FALSFEQMEWASCEYYS-HHGKM 57 K I I GDGIG ++ P I+V+ AA E+ +++ ++ Sbjct: 26 PKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTW 85 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P + + + + G + P + + R++ D YV RPVR F GVP Sbjct: 86 LPQETLDAVRDYVVSIKGPLTTP----VGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPS 141 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQ 158 P+ +PGD+D + REN+E Y+ + + +V I Sbjct: 142 PVK--KPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIG 199 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY----- 213 ++ G R++R A + A R ++T K N + + + + +A + Sbjct: 200 IKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAEL 259 Query: 214 ---------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + D + + +++P +DV+ NL GD LSD A Sbjct: 260 LDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEV 319 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G IGIAP ANL+ ++FE HG+AP G++ NP + I + MML +G + Sbjct: 320 GGIGIAPGANLSDS---VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRHMG-----W 371 Query: 319 QQAHNGILAAIEEVIAHGPKTPD----MKGN--ATTPQVADAICKII 359 +A + I+ IA T D M G + + DA+ + Sbjct: 372 TEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 100/406 (24%), Positives = 158/406 (38%), Gaps = 62/406 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ + ++ A E+ G + A + G+ +P Sbjct: 36 PDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLP 95 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + + L G +G P + RR FD Y +RPV G P+ Sbjct: 96 QETLDVLKESIVGIKGPLGTP----VGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPI 150 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVN-------------------EGTEHEVVIQES 160 P +D V RENT+ Y+ + EG +V I Sbjct: 151 PN--PERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVK 208 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN-------- 212 + R +R A A +K + K N + + + +AE Sbjct: 209 PMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVV 268 Query: 213 --------YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIA 264 +++ K D + + V++PE +DV++A NL GD +SDL + G G Sbjct: 269 TDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFV 328 Query: 265 PSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 PS N+ +LFE HG+A DI GK IANP++ +GAMML+++G +++A Sbjct: 329 PSGNIGDGY---ALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIG-----WKEAAQK 380 Query: 325 ILAAIEEVIAHGPKTPDM----------KGNATTPQVADAICKIIL 360 + A+ +A TPD+ T + A+ I K I Sbjct: 381 VYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 95/405 (23%), Positives = 154/405 (38%), Gaps = 61/405 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 + +A GDGIG E++ +VL AA ++ G A E G ++P Sbjct: 30 PDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLP 89 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D + G + P + R D Y N+RPV+ + G P P Sbjct: 90 DGTLQAFKLARVNLKGPLTTP----VGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTP- 143 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFT 163 P +ID+ + RENTE Y+ + + I + Sbjct: 144 -HCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPIS 202 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV---------------EA 208 + R +R A E A K +T K N + + + + E Sbjct: 203 KWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEE 262 Query: 209 MAENYPE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + Y I + + D + + + +P ++V+V NL GD +SD A G IG Sbjct: 263 VNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIG 322 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQA 321 +A ++ ++ EPVHGSAP GKN+ NP A I +G +L DF+G + + Sbjct: 323 MAAGLDMGD---GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKL--- 376 Query: 322 HNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIIL 360 + A+++ IAH T D+ +T + D + I Sbjct: 377 --LVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 89/359 (24%), Positives = 162/359 (45%), Gaps = 27/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + +PGDG+G E++ V +AAA + F++ + + + K+ + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL--EQVL 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P ++ ++ RR+ D + N+ V+ PG + Sbjct: 102 SSMKENKVAIIGKIHTPMEYKGELA--SYDMRLRRKLDLFANVVHVKSLPGYMT-----R 154 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RE TEGEYSSL G V+ + TR RI ++AF+ A + R Sbjct: 155 HNNLDLVIIREQTEGEYSSLEHESARG----VIECLKIVTRAKSQRIAKFAFDYATKKGR 210 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T+ K+N + + + + E +AE YP+I+++ ID C + V P +FDV+V Sbjct: 211 GKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ +L G G+ P + + E ++FE G+NIANP A + Sbjct: 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEY---AVFETGARHPFAQAVGRNIANPTAMLL 327 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAA-IEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + ML L + + I A + + +T DM G +TT ++ + Sbjct: 328 SASNMLRHL-----NLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 381 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 321 bits (823), Expect = 3e-86, Method: Composition-based stats. Identities = 123/356 (34%), Positives = 170/356 (47%), Gaps = 37/356 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+A IPGDGIG EV+ +RVL+A R F + + + G + ++ E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGRVRF-----EYYEGGVDVFQECGSPIREEDLE 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ R DA+ FGA P +P +L R+E Y NLR + P + Sbjct: 57 EIRRSDAVLFGATTTPFDLP---GYRSLILTLRKELGLYANLR---IIPDLRT------- 103 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + +VREN+EG Y +G V + + + TR G +RI R+A E A++R Sbjct: 104 -GREIVIVRENSEGLYFGIGAVV-----NGRAVDVRLITREGAERIARFAVEQAKARG-S 156 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K+N L ++ V +A + ID + V P V+++ N Sbjct: 157 FITFVHKANVL-TGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVILSEN 214 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSDL G+IGI PS N +LFEPVHGSAPDI GK IANPI I +G Sbjct: 215 LFGDILSDLATVHAGSIGIVPSGNYGD---GIALFEPVHGSAPDIAGKGIANPIGAILSG 271 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AM+LD+LG I AA+ + +G TPDM G A T V I I Sbjct: 272 AMLLDYLGLDGS-------LIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIE 320 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 320 bits (820), Expect = 6e-86, Method: Composition-based stats. Identities = 132/370 (35%), Positives = 181/370 (48%), Gaps = 26/370 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPD 60 M RI I GDGIG E++ +RVL A AE + +E +E A + Y G + Sbjct: 1 MTGTRIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAE 60 Query: 61 DWHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLL-KFRREFDQYVNLRPVRLFPGVPCP 118 +L DA G VG PD G L R D Y N+RPVR +PGVP Sbjct: 61 ADVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSR 120 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + + +D+ +VRENTEG Y+S G V V + TR G R+ R AF LA Sbjct: 121 VRADR---VDYVIVRENTEGLYASRGKGVGNRW---AVTDTLLTTREGTLRVARKAFTLA 174 Query: 179 QSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 R + +T KSN L S ++ E V +A +PE+ + ++ D V+ Sbjct: 175 AGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVELEYRYADAAAQDLVL 233 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 PERFDV+V N GD+LSDLG A G +G+ P+ N+ + FEPVHGSAPD+ G+ Sbjct: 234 CPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD---GAAYFEPVHGSAPDLVGR 290 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA--TTPQ 350 N ANP+ + A AM+LD LG+ DE + A+ V+A G + G Sbjct: 291 NRANPVGQLLAAAMLLDHLGHVDE-----AARLRRAVSAVLAFGTVRIEADGTVLGGAEA 345 Query: 351 VADAICKIIL 360 VADA+ + Sbjct: 346 VADAVIAALQ 355 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 319 bits (819), Expect = 7e-86, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 12/365 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA I GDGIG +V I VL+ A + G A Y+ G + D E Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DAI+ GA+G P + + L+ R F Y +RPV+ +P P LA + Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120 Query: 125 GDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR-- 181 ID ++RE+TEG YS+ + + + V TR+ ++ R+AF LA+ R Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRE 180 Query: 182 --PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 LT K+N S+ ++ + + + + ++ ++D V +P FDV Sbjct: 181 RGHPGRLTCVDKANVF-TSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+A + LF+P HGSAPDI G++ ANP+A Sbjct: 240 LVMENMFGDILSDLAGGLVGGMGMAACGEIGD---TTGLFQPAHGSAPDIMGEDKANPLA 296 Query: 300 TIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAIC 356 I + A+MLD+L A I +A+E H + + G+ T V + Sbjct: 297 AILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKELL 356 Query: 357 KIILR 361 + + Sbjct: 357 GRVAQ 361 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 106/380 (27%), Positives = 157/380 (41%), Gaps = 39/380 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+ + I GDG G E++ VL AA GF L ++ A G+++P Sbjct: 1 MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRP-AGQGALRSVGELLPAS 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + R G P + + RRE D Y +RPVR++PG AG Sbjct: 60 TLDSIRRNGVALKGPTTTPI----GVGHRSVNITIRRELDLYACVRPVRVWPG-----AG 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT--------------EHEVVIQESVFTRRGV 167 ID VVRENTE YS L + + + T G Sbjct: 111 AVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPITPGGS 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI+ +A + A+ R+ + + + E + YP+I + +LC Sbjct: 171 RRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPVTVLC 230 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 V P DV+V NL+GD++SD+ A G +G+AP AN+ ++FE HGSAP Sbjct: 231 DSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR---TAVFEATHGSAP 287 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM---- 342 + G N NP A I +G M+LD LG I AA+ V+ G T D+ Sbjct: 288 EFAGSNRLNPTALILSGCMLLDHLGE-----APTAARIRAAVRSVLEEGRSVTFDLLPPD 342 Query: 343 --KGNATTPQVADAICKIIL 360 TT A+A+ + + Sbjct: 343 RAARAVTTTAYAEAVIERLR 362 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 318 bits (814), Expect = 2e-85, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 157/360 (43%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PG GIG E + + + G + FE ++ Sbjct: 56 RHAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDPTMDNDDD----VQYAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + + + R E D Y + + +PGV + Sbjct: 108 TTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVAT-----R 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID ++R+NTEGEY+ L G VV V T +R+ R+AFE A+ R Sbjct: 160 HKDIDVVIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAKKNGR 215 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + E +A+ YP+I D ID C + V +P +FDV++ + Sbjct: 216 KKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLMT 275 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G I+S++ G G+ N ++FEP + I GKNIANPIA I Sbjct: 276 NLYGSIVSNVVCGLLGGAGLLSGRNYGDHY---AVFEPGTRNTGTAIAGKNIANPIAMIN 332 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIILR 361 A ML+ LG+ Q + + AI + I TPD+ G+ T+ V AI + + R Sbjct: 333 ASIDMLEHLGH-----QFHASLLRRAINKTINVDRVLTPDLGGSNTSTDVVGAILQNVGR 387 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 102/382 (26%), Positives = 164/382 (42%), Gaps = 43/382 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++ +PGD IG E++ E +++L E G + D Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPG---V 115 + E DA+ G+VG P+ P +S +L R+ D + N+RP R + Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLN 120 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 PL + +DF +VREN G Y + R V+R R + Sbjct: 121 QSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARVSA 168 Query: 176 ELAQSRPRKT---------LTSATKSNGLAISMPYWDERVEAM-AENYPEIRWDKQHIDI 225 LA++ R + +A K+N LA +W + +P+I Q D Sbjct: 169 ALARTFGRGKNTDDKSPAIVWNADKANVLASGR-FWRTVTHDIFEREFPDIELHDQLADS 227 Query: 226 LCARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFE 280 + V P +F+ V+ N FGDILSD+ G++G+ PSA++ E+ ++E Sbjct: 228 MAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYE 287 Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA------ 334 VHGSAPDI G ANPIA I + AM+L + + + + A+ + + Sbjct: 288 AVHGSAPDISGTGQANPIAQILSLAMLLRY----SFSMPRQADLLEDAVRKTLEVREHGG 343 Query: 335 HGPKTPDMKGNATTPQVADAIC 356 G +T D+ G+A+T V DA+ Sbjct: 344 LGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 92/407 (22%), Positives = 150/407 (36%), Gaps = 64/407 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYS-HHGKM 57 I I GDGIG +V P ++V+ AA + + + ++ Sbjct: 24 PNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETW 83 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P++ L + G + P + + R+ D YV RPV+ F GVP Sbjct: 84 LPEETLNILQEYKVSIKGPLTTP----VGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPS 139 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQ 158 P+ +P ++D + RENTE Y+ + + V I Sbjct: 140 PVK--RPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIG 197 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY----- 213 ++ G R++R A + A + ++T K N + + + + +A Sbjct: 198 IKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASL 257 Query: 214 ---------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 EI D + + +++P + V+ NL GD LSD A Sbjct: 258 LHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQV 317 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G IGIAP ANL E ++FE HG+AP GKN NP + I + MML +G + Sbjct: 318 GGIGIAPGANLGDE---VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWLE--- 371 Query: 319 QQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVADAICKII 359 + +L + I T D + D I + Sbjct: 372 ---ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 313 bits (802), Expect = 8e-84, Method: Composition-based stats. Identities = 101/395 (25%), Positives = 165/395 (41%), Gaps = 55/395 (13%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS-----HHGKM 57 ++ +PGD G +++ + VL + + + + + C + G Sbjct: 13 DRYKVCYMPGDDSGFDMMEGALVVLLSM----DLPIDWVRADLGWCMWEKSVNKFGQGDP 68 Query: 58 ----MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 +P + +++ DA A+ ++L+ R+ FD Y+NLRP + P Sbjct: 69 RCNTVPPETIDKIRSSDATLMAAITSKS---GVKGFKSAILQMRQLFDLYINLRPAKTLP 125 Query: 114 GVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-------------HEVVIQES 160 + PL G ID + RENTE YS++ +V + Sbjct: 126 DLGSPLKGD--PKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDVAVSWR 183 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP--EIRW 218 VF+ G +RI+R AFE A+S R + K+N + + +A+ Y I Sbjct: 184 VFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQYGITG 243 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++ D + P+ + V+V SN+FGDILSD TG +G APS N+ ++ Sbjct: 244 IEENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGEN---TAI 300 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH--- 335 FEP GS P + NP A + MML++LG QA I AI EV+ Sbjct: 301 FEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLG-----LDQAGQKIEWAINEVLKENRP 355 Query: 336 GPKTPDM-----------KGNATTPQVADAICKII 359 T D+ + A+T ++A AI + I Sbjct: 356 KTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 91/414 (21%), Positives = 156/414 (37%), Gaps = 71/414 (17%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGK--- 56 I I GDGIG ++ P I+V+ +A ++ G + + Y Sbjct: 27 PNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKE 86 Query: 57 ------MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 + D E ++ + G + P + R++ D YV LRPVR Sbjct: 87 LSPEEQWLLPDTIEAINHYKVSIKGPLTTPI----GEGFRSLNVALRQKMDLYVCLRPVR 142 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT------------------- 151 + G P P+ Q +D + REN+E Y+ + + Sbjct: 143 WY-GSPSPVKEPQ--KVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRF 199 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA- 210 + ++ G +R++R A E A + ++T K N + + + + A+A Sbjct: 200 PESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQ 259 Query: 211 ENY-------------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILS 251 + + EI D + +++P + V+ NL GD +S Sbjct: 260 KEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYIS 319 Query: 252 DLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFL 311 D A G IGIAP ANLN +FE HG+AP G + NP + I + MML + Sbjct: 320 DALAAMVGGIGIAPGANLND---TVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHM 376 Query: 312 GNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKII 359 G + +A + I++A+E+ I T D + A + + + Sbjct: 377 G-----WVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 311 bits (797), Expect = 2e-83, Method: Composition-based stats. Identities = 112/373 (30%), Positives = 178/373 (47%), Gaps = 42/373 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG----K 56 M K + A + GDGIG EV+ +RVL+ + L A E + +G Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCE-----AGSEQWDKNGRKDAS 53 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 +PD + L D + G +P + + R++FD Y N+RP + + Sbjct: 54 YIPDVTMKILEETDCCFKGPTTT---IPVPGAPRSVAVTLRQKFDLYANIRPTKTYD--- 107 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 +D RE TEG Y+ + ++ + I TR+G R++ A + Sbjct: 108 ---RLTPDRKLDCVCFREATEGLYTGVEAKI----TDDAAIAIRKITRQGSRRLIDSAVD 160 Query: 177 LAQSRPRKTLTSATKSNGLAISMP-YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 A K + + TK N L + +WDE +A+ +I + +ID + + V+ E Sbjct: 161 WANKFNMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQMVIATE 218 Query: 236 RFD--VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 +F+ V+V++NLF DI+S+L A G+IG+ SAN+ ++FE HGSAP G+N Sbjct: 219 QFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDNY---AMFEAAHGSAPQFAGQN 275 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 NP AT+ +GA M D+LG D R + I AA E+VI G T D+ G+A+T Q+ Sbjct: 276 KVNPTATVLSGAWMADYLGERDVR-----DAIFAATEQVINEGKAVTWDIGGDASTTQMT 330 Query: 353 DAIC----KIILR 361 DAI + + + Sbjct: 331 DAIITYAKEKLRK 343 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 309 bits (793), Expect = 7e-83, Method: Composition-based stats. Identities = 143/385 (37%), Positives = 196/385 (50%), Gaps = 35/385 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++ ++A +PGDGIG EV+ L+A G AL ++ W + ++ HG+MMP DW Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEAL---PGPALVLTELGWPAHAWHRDHGEMMPADW 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISL-------WGSLLKFRREFDQYVNLRPVRLFPGV 115 QL+ +DA+ GA+G P D LL+ R+ D + RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 P PL+ + D V+REN+EGEY GGR+ GT E Q VFTR G +RI+R+AF Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAF 182 Query: 176 ELA----------QSRPR---------KTLTSATKSNGLAISMPYWDERVEAMAENYPEI 216 E A PR + TK N + + W E +A YP I Sbjct: 183 ERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPGI 242 Query: 217 RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP-ERTF 275 + ID C +FV QP +FDVVVASNL GDIL+DL G +G+APSANLNP +R+ Sbjct: 243 ATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSV 302 Query: 276 PSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 P LFEP HGSAPDI G + A+P A + A ML+++G D ++ + A+ E IA Sbjct: 303 PPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE 362 Query: 336 GPKTPDMKGNATTPQVADAICKIIL 360 M G +V A+ + I Sbjct: 363 HG----MGGR-GCAEVGRAVAQRIR 382 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 309 bits (792), Expect = 1e-82, Method: Composition-based stats. Identities = 96/404 (23%), Positives = 164/404 (40%), Gaps = 61/404 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYSHHGKMM 58 IA I GDG+G++V+P +V+ +A + + Q+ + G Sbjct: 29 PLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDWF 88 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P + + G + P + R+E D +VN+R ++ F +P P Sbjct: 89 PQETINAVRECKIAIKGPLTTPL----GGGFRSLNVALRQEMDLFVNMRTIKGFSALPSP 144 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQE 159 L + V+R+++E YS + + +V I Sbjct: 145 LKNPYL--TNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGI 202 Query: 160 SVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NY----- 213 ++ G +R++RYA A ++LT K N L + + A+A+ Y Sbjct: 203 KNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQAIDD 262 Query: 214 -------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGT 260 P + + D + + +M PE+FDVV +N GD L+D+ A G Sbjct: 263 ENGRWLHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADMLSAQVGG 322 Query: 261 IGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQ 320 +GI P+ANLN E + FEP HG+ I G+N ANP ++I + +ML F+ ++ + Sbjct: 323 VGIMPAANLNNE---VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKFM-----QWHE 374 Query: 321 AHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKI 358 A N I A+E +A G T D+ + A + + Sbjct: 375 AANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 306 bits (785), Expect = 6e-82, Method: Composition-based stats. Identities = 112/374 (29%), Positives = 175/374 (46%), Gaps = 24/374 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M T IA + GDGIG EV+ E ++VL+ +R + + + Y+ G PD Sbjct: 1 MTTYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYF-AMGHAFPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV-----PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + + DAI G +G D G+LL RR ++ + N RPV L G+ Sbjct: 60 ETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGL 119 Query: 116 P--CPLAGKQ-PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL ID ++RE G Y V + + + +I++ Sbjct: 120 AHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVK 179 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 FE++ R +K + + KSN L S W+E VE ++NYPE+ +D + Sbjct: 180 VGFEVSMKR-KKVMHNIHKSNVLKSS-VLWNEIVEEESKNYPEVEVKNILVDAAATYLCL 237 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P FDV+V N+FGDILSD G G++G+ PSA P++++ +EP HGSAPDI GK Sbjct: 238 NPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSY---YEPSHGSAPDIAGK 294 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM-----KGNAT 347 IANP + I + A+ML+ ++ + AA++ V +G T D+ + Sbjct: 295 GIANPYSMIGSVALMLE----MSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVS 350 Query: 348 TPQVADAICKIILR 361 T + D +C + + Sbjct: 351 TAEFGDLVCAELAK 364 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 306 bits (785), Expect = 7e-82, Method: Composition-based stats. Identities = 87/374 (23%), Positives = 149/374 (39%), Gaps = 39/374 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ + GD IG EV+ E + + +G + + H + + Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGG-SCLDQHDCPIQES 68 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHI--SLWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 ++ S A+ G+VG P +L+ R+ + Y N+RP ++ Sbjct: 69 TLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L ++ +REN G Y + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI--RWDKQHIDILCARFVMQP 234 LA S + S K+N +A S + E + + +P++ + Q +D P Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN-------PERTFPSLFEPVHGSA 286 + + VV+ NLFGDILSDL G++G+ SA ++ R +++PV GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 PDI GK IANPI + +M + +A + I +AI++ + G T D+ G Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRW----SLGLPKAADAIDSAIKDCLESGQCTRDVGGTL 345 Query: 347 TTPQVADAICKIIL 360 +T Q A+ + I Sbjct: 346 STQQAGSALRQSIQ 359 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 117/361 (32%), Positives = 177/361 (49%), Gaps = 32/361 (8%) Query: 1 MMK--TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M + I I GDGIG+EV+P + VLQA E SF + A + G + Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTEK-QAGDDTRDQTGAAL 56 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P+ +E + DA FGA G + +L R +VN+RP R +PGV Sbjct: 57 PETTYEAAADADATLFGAAG--------ETAADVILPLREAVGSFVNIRPARAYPGV--- 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + D +RENTEG YS R++ ++ V T +++ YA Sbjct: 106 --DALQPETDLVFLRENTEGVYSGHEDRLS----EDLSTLTRVITTSASEQLAEYACSYV 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R + K+N + + + + V +A + ++ ++ +D R + P +FD Sbjct: 160 TERSIDGFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLNPTQFD 218 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVV NL GD+LSDL G +G+ PSAN+ +LFEPVHG+APDI G IANP Sbjct: 219 VVVCPNLAGDVLSDLAAGLVGGLGLLPSANIG---QTNALFEPVHGTAPDIAGDGIANPS 275 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A+I + M+L++LG D A + A+E V+ GP+TPD+ GNA+T V +A+ + Sbjct: 276 ASILSAGMLLEYLGETD-----AATNVQMAVESVLNSGPRTPDLGGNASTEAVVNAVIEQ 330 Query: 359 I 359 + Sbjct: 331 L 331 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 119/364 (32%), Positives = 172/364 (47%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + RI AIPG+GIG EV+ +++LQ A+ GF L + W + G P Sbjct: 7 ASYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVD-YGWLGATAFEQLGSYFPQAT 65 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLA 120 E D I FGAV G LL+ R+ FD + NLRP+R + L Sbjct: 66 TELCDGADGIVFGAVS-----------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLR 114 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ +D +VRE G Y GR ++ + + + RI R A E AQ Sbjct: 115 PEKIQGLDILIVRELVSGIYFGPSGRSSDERGN-YGYHTMRYYDEEIRRIARKALEQAQY 173 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R LT A K N L +W V+ A +P + + +D L + V+ P+RFDV+ Sbjct: 174 R-RGLLTVAHKENALPH--LHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 +ASNLFGDILSD+G A G+IG+ SA+LN L+E +HG+APDI G IANP+ T Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNA--NGFGLYEAIHGTAPDIAGLGIANPLGT 288 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAI 355 + A +ML G Q + ++A G +T D+ T + D + Sbjct: 289 LGACVLMLQQWGEVQAAQQIIAAQ-----DRILAKGYRTADLFTQGEEILVNTATLVDLL 343 Query: 356 CKII 359 + + Sbjct: 344 LEEL 347 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 95/361 (26%), Positives = 171/361 (47%), Gaps = 31/361 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + + +PGDGIG E++ + I+++++ G+ ++ + ++ Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKS-CIYTGYKINIIYNYIGGIS-IDKFNTPITNNLIS 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + D I+ G VG LLK R++F+ + N+RP++ Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK-----------CPF 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV----VIQESVFTRRGVDRILRYAFELAQS 180 +ID +VRE G Y ++ +++ ++ + + R+ R +F LA + Sbjct: 109 KNIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLALN 168 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R +K L S KSN L + W + + + + Y +++ +ID + +FDV+ Sbjct: 169 R-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFDVI 226 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 + SNLFGDI+SDL TG++G+ PS ++N SLFEP HGSAPDI KNIANP+ Sbjct: 227 ITSNLFGDIISDLCSLLTGSLGMLPSISINN--KSLSLFEPCHGSAPDIANKNIANPVGA 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + + MM +++ + N + +I +V+++G T DMK +T + D Sbjct: 285 LLSLVMMFEYV----LNDFKLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDL 340 Query: 355 I 355 + Sbjct: 341 V 341 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 297 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 97/405 (23%), Positives = 159/405 (39%), Gaps = 69/405 (17%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC----------------- 48 ++ +PGDGIG E+ + A + ++ + Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYA----NIPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 49 -EYYSHHGKMMP-----------------------DDWHEQLSRFDAIYFGAVGWPDTVP 84 E G+ P D H+ + + G D Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGPFITRDVSK 154 Query: 85 DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLG 144 + ++ Y ++ PV+ +P P D+D VVRENTE EYS L Sbjct: 155 SIDRMLAL------KYGLYAHVVPVKAPQNLP-PSVFTPFRDVDMVVVRENTEAEYSGLE 207 Query: 145 GRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE 204 +V G VV + TR G RI ++AFE A+ R + + K+N + S + E Sbjct: 208 HQVQPG----VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIE 263 Query: 205 RVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVVASNLFGDILSDLGPACTGTIG 262 + +A+ YP+I++ + +D + V P FD VVV NL+G I+S+ + G +G Sbjct: 264 CCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVG 323 Query: 263 IAPSANLNPERTFPS--LFE-PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQ 319 + N + +FE A DI G+ IANPI I + MLD +G Sbjct: 324 VISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMG-----MN 378 Query: 320 QAHNGILAAIEEVIAH---GPKTPDMKGNATTPQVADAICKIILR 361 N I A++E + + TPD+ G ++ +A+ + I + Sbjct: 379 THANRIKFALKETLLNANPKILTPDIGGTGSSVSFIEAMMRHIPK 423 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 297 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 115/366 (31%), Positives = 175/366 (47%), Gaps = 31/366 (8%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + EG++VL A +E G + E + Y P D ++ D I GAVGW Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 80 PDTVPDHISLW---------GSLLKFRREFDQYVNLRPVRLFPGVPCPLAG-----KQPG 125 PD + ++ R + Y N+RP++L+PGV + G + G Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK- 184 +D ++RENTEG Y+ GG++ G + +V I V TRR ++++R+AFEL + R + Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 185 ------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +T+ K N L + + + YPEI D +D V QPE +D Sbjct: 181 PKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYD 239 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V V SN+FGDI++DL G +G+A N+ ++FEP+HGSAP GK+ NPI Sbjct: 240 VCVTSNMFGDIVTDLASTLQGGMGMAVGGNIG---KHNAMFEPIHGSAPKHAGKDKVNPI 296 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVA 352 A I + L++L D +A I AA+ EV+ G T D+ GN + +V Sbjct: 297 AMILSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVG 356 Query: 353 DAICKI 358 AI + Sbjct: 357 SAIAEA 362 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 294 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 94/463 (20%), Positives = 159/463 (34%), Gaps = 121/463 (26%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYSHHGKM- 57 + I GDG G ++ P +VL AA + +S+ ++ A E +G Sbjct: 24 PDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVY-AGDEACDLYGTYQ 82 Query: 58 -MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 +P D + + G + P + + R+ FD Y +RP R + G P Sbjct: 83 YLPQDTLTAIKEYGIAIKGPLTTPI----GGGIRSLNVALRQIFDLYACVRPCRYYAGTP 138 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH----------------------- 153 P P +D V RENTE Y + + Sbjct: 139 SPHKS--PDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIP 196 Query: 154 -EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA 210 + I +R G R++R A + A P++ +T K N + + + + +A Sbjct: 197 LDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELA 256 Query: 211 --------------------ENYPEIRWDK--QHID------------------------ 224 E P+I ++ + ID Sbjct: 257 TQEFRAECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTPEKKAQIVKEVETVINS 316 Query: 225 ----------------------ILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + + +P+ + ++ NL GD LSD A G +G Sbjct: 317 IWSTHGDGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLG 376 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAH 322 + P AN+ ++FE HG+AP G + NP + I +G MML+++G +Q+A Sbjct: 377 MGPGANIGDS---CAIFEATHGTAPKHAGLDKINPGSVILSGVMMLEYMG-----WQEAA 428 Query: 323 NGILAAIEEVIAHGPKTPDMKG-------NATTPQVADAICKI 358 + I + IA G T D+ + AD I + Sbjct: 429 DLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 292 bits (749), Expect = 9e-78, Method: Composition-based stats. Identities = 118/402 (29%), Positives = 165/402 (41%), Gaps = 65/402 (16%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 RI +PGDGIG E+ ++ W + HG +P + Sbjct: 13 APRRITLLPGDGIGPEITDACRGLIADVFPHWEL-----TETQIGWSQWRAHGNPVPQET 67 Query: 63 HEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 E L R DA A+ P ++ +L+ R+ D + N+RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-T 126 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSS----LGGRVNEGTEH-------------- 153 PG DF +VRENTEG YS + H Sbjct: 127 LPGAAA----------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVA 176 Query: 154 -------EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--------LTSATKSNGLAIS 198 EV + V T R+ R A +LA +R +T A K N L S Sbjct: 177 RAVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDS 236 Query: 199 MPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 VE +AE YP++ +D + D + + V P RFDV++A NL GDILSD+G Sbjct: 237 ARVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLI 296 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +G+A SAN+ ++FEPVHGSAPDI G+ IANP A + + AM + LG Sbjct: 297 GGLGLAASANVGDN---FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSEL 353 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 A + A+ P T D+ G ATT + A+ + Sbjct: 354 APAA-KLREAVYAATRTAP-TLDLGGTATTSEFVAAVRAELG 393 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 292 bits (748), Expect = 1e-77, Method: Composition-based stats. Identities = 84/298 (28%), Positives = 130/298 (43%), Gaps = 25/298 (8%) Query: 39 SFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRR 98 FE++ +S + + R G + +P S R Sbjct: 1 DFEEVHVSSNADEEDIRNAI-----MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRT 53 Query: 99 EFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 D Y N+ + PGV + DID +VRENTEGEYSSL G VV Sbjct: 54 SLDLYANVIHWKSLPGVVT-----RHKDIDILIVRENTEGEYSSLEHESVAG----VVES 104 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T+ RI YAF+LAQ RK +T+ K+N + + + + +A YP+I + Sbjct: 105 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITF 164 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 + +D + V +P++FDV+V NL+G+I++++ G G+ AN ++ Sbjct: 165 ENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AV 221 Query: 279 FE-PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 FE + I KNIANP AT+ A MMLD L + I A+ + + Sbjct: 222 FETATRNTGKSIANKNIANPTATLLASCMMLDHL-----KLHSYATSIRKAVLASMDN 274 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 92/359 (25%), Positives = 161/359 (44%), Gaps = 28/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + G GIG E++ +RVL+AA G LS+E +S + ++ D+ Sbjct: 37 KTNVTILTGSGIGPEIMDHTLRVLKAA----GAPLSYEIFALSSKDGSKNND---FDEAL 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P + + FR+ D +V + + FPG+ + Sbjct: 90 TSIRRNRVALKGNIELQSKNP---HIKSRNIIFRKTLDLFVYILFCKTFPGLS-----NK 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G+ID V+R+NTEGEY L G+ V V TR ++R++ +AF+ A + R Sbjct: 142 FGEIDITVIRQNTEGEYLMLEHEPRTGS----VESLKVLTRFNLERLIEFAFDYALTNDR 197 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T +N ++ + ++++YP I+ + +++ + P FDV++A+ Sbjct: 198 KLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVILAT 257 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL G ++S+ G G+ N + + ++FEP I G N ANPIA I Sbjct: 258 NLNGSMISNYLNGMLGGPGLTSGINFSAD--GIAVFEPGARNKGSSIVGLNRANPIAMIM 315 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G +L LG + I ++ + +TPD+ G AT + D I + I Sbjct: 316 SGINLLHHLGY-----NKTAEMIHNSVYATLVYDKIRTPDIGGQATAEETVDHIIRHIR 369 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 96/367 (26%), Positives = 169/367 (46%), Gaps = 30/367 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF--ALSFEQMEWASCEYYSHHGKMMPD 60 + I GDGIG + + R+L+ + + F+ ++ + E + +P Sbjct: 40 DKIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPA 99 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + ++L I G P ++ + + R+E D + N+RPVR+ Sbjct: 100 EVLKELKECHVILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE------- 152 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ID+ RENTEG Y+ G ++ + +V T G +RI+R AFE A++ Sbjct: 153 ----QGIDWTFYRENTEGAYAV--GSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKA 206 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV--MQPERFD 238 + +T+ TK+N + + + + +A++Y +I D +IDI+ A+ + + + F Sbjct: 207 NGKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKDFQ 266 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---A 295 V+V NL+GDI++D G +G A SAN+ S+FE +HGSAP + + A Sbjct: 267 VMVLPNLYGDIITDEAAEFQGGVGTAGSANIGKRY---SMFEAIHGSAPRMVQEGRDQYA 323 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE--EVIAHGPKTPDMKGNATTPQVAD 353 +P + I AGAM+L +G G + + + A++ V AT + AD Sbjct: 324 DPCSVIRAGAMLLAHIGYG-----KEADKLYQALDICTVTEKKLVITGRNTGATGAEFAD 378 Query: 354 AICKIIL 360 I + I Sbjct: 379 YIMETIE 385 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 87/364 (23%), Positives = 153/364 (42%), Gaps = 26/364 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAA--ERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + +PGDGIG ++ + +RV + E + F + + E + +P + Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E D + G P ++ + RR Y +RPVR+ Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE--------- 157 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ REN EGEY + G + ++ + V TR G +RI R AFE A++ Sbjct: 158 --KGIDWTFFRENIEGEY--IWGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNG 213 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ--PERFDVV 240 + +T TK+N + + + + A+ + YP I ++ +D + A+ Q + V Sbjct: 214 KTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 + NL+GDI++D+ G +G A S+N+ + +LFE +HG + N A+P Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQY---ALFEAIHGVGNFLVQHNRAQYADP 330 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 + I A M+ +G +++ Q T D G AT + D + Sbjct: 331 CSLIRAMGEMISHIGYPEKKEQLVKAL--DICTRTERKVVITTDKDG-ATAEEFTDYLLD 387 Query: 358 IILR 361 + R Sbjct: 388 TLQR 391 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 279 bits (715), Expect = 9e-74, Method: Composition-based stats. Identities = 92/361 (25%), Positives = 155/361 (42%), Gaps = 29/361 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ + G G+G++ R+ AA + FE + A H +P + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFE-VHLAGRMALEHGKDALPKATFDA 57 Query: 66 LSRFDAIYF------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + VG P + FRR+ + ++RPV PG+P Sbjct: 58 IRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPS-- 115 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +DF + RE TE Y++ + G VV + T R + AF+ A+ Sbjct: 116 ---RFTGVDFLLFREITEDLYTASEHEIVPG----VVQSFKIVTEAACLRFFKLAFDTAR 168 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RKT+ K+N L ++ + E +A+ YPEI +D C + V +P++F+V Sbjct: 169 KRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEV 228 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + A NL+GD+LSDLG G + + N +++E V+G++ + +++NP+ Sbjct: 229 LAAGNLYGDLLSDLGAGLVGGVSTTAAINKG---NGTTVYEAVYGASHEAVPPDMSNPLP 285 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I +L LG I A+E V+ G +T D+ G ATT DAI Sbjct: 286 LILPAIELLKDLGETGT-----AGRIQKAVETVLLEGRIRTRDIGGTATTTAFTDAIVSR 340 Query: 359 I 359 + Sbjct: 341 M 341 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 279 bits (714), Expect = 1e-73, Method: Composition-based stats. Identities = 91/365 (24%), Positives = 158/365 (43%), Gaps = 28/365 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS--CEYYSHHGKMMPDDW 62 +++ +PGDGIG ++ + V + ++ E + E + K +P Sbjct: 38 VKVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAV 97 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E D + G P +L + RR+ Y +RP+R+ Sbjct: 98 LEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE--------- 148 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ REN EGEY + G ++ I + ++ G +R+ R AFE A+S Sbjct: 149 --KGIDWTFFRENIEGEY--IWGNKGICVGDDLAIDFKILSKPGAERLFRNAFEYAKSSG 204 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE---RFDV 239 + +T ATK+N + + + + AM + YP I ++ ID L A+ + PE V Sbjct: 205 KTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DPEFNAGMQV 263 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---AN 296 V NL+GDIL+D+ G +G A S+N+ + ++FE +HG + N A+ Sbjct: 264 FVLPNLYGDILTDIAAEYQGGLGTASSSNIGDQY---AMFEAIHGVGVYLVEHNRAQYAD 320 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 P + I A M+ F+G ++R + +V T D G AT + A+ + Sbjct: 321 PSSLIRAMGEMMAFIGYPEKRDRLFKAL--DFCTKVERKAVITTDKDG-ATAEEFAEYVV 377 Query: 357 KIILR 361 + + + Sbjct: 378 ETLHK 382 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 94/367 (25%), Positives = 153/367 (41%), Gaps = 17/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + IA IPGDG+G E+ E + L+ A E +G + F + A +P + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEA-IAGTAALDRGQCPLPRE 69 Query: 62 WHEQLSRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 + D+I G AVG + L R ++RP + C Sbjct: 70 SLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 118 PLAGK-QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + + +D ++R+ G ++ G+ + + + R AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFT-TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA SR R +TS K+ L S W + +E +YPEI + +D + V P+ Sbjct: 189 LAASRKR-KVTSLDKA-ILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDA 246 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+VASN+FGDI++D TG P+ +LN ER +H ++ G AN Sbjct: 247 FDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRAN 306 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPD--MKG--NATTPQVA 352 P+ I A AMML++ + G+ A+ V+ G G A T + Sbjct: 307 PVGMILAAAMMLEY----SFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIG 362 Query: 353 DAICKII 359 +A+ + + Sbjct: 363 EAVRECL 369 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 277 bits (708), Expect = 5e-73, Method: Composition-based stats. Identities = 108/368 (29%), Positives = 176/368 (47%), Gaps = 45/368 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIGKE++P+ ++ + F S E Y + G + D ++L Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTF-----YNISSERYINKGITIKDSEIDEL 58 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +++I+FGA+G P I G +L+ R+E D Y+N+RP F + + Sbjct: 59 KSYNSIFFGAIGDFRVKPG-IMEQGVILRLRKELDLYMNIRPAISFSRITG-------NN 110 Query: 127 IDFYVVRENTEGEYSSLGG-------------------RVNEGTEHEVVIQESVFTRRGV 167 I ++REN E YS + G +N ++ + +R+ + Sbjct: 111 IHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNL 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 R A+++A +T+T K+N + + W E +E + + ++ D L Sbjct: 171 KRFFNMAYKIA---DTETVTITDKANAVDMYS-LWREIAIEESEP-AGKKINFEYADSLA 225 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P ++ ++A NL+GDILSD+ A G +G APS N+ + S+FEPVHGSAP Sbjct: 226 YNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD---YSSMFEPVHGSAP 282 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 DI GKNIANP+A+I + MML L + + ++E VI +G + GNA Sbjct: 283 DIAGKNIANPVASILSCIMMLKHLNQTET-----AGIMEKSVENVIRNGTIPIESGGNAG 337 Query: 348 TPQVADAI 355 T + + + Sbjct: 338 THEFINKV 345 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 274 bits (701), Expect = 4e-72, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 150/359 (41%), Gaps = 21/359 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG+G+G EV+ + +L+ E G + G+ + + Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV---- 85 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAGKQP 124 F A F G P + RR FD Y L P+R +P + L + Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAA 142 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VREN G Y G EG Q + V+RILR A LA R R Sbjct: 143 RSADVLIVRENASGLYCGEWGSEGEGA-ARSAYQVCRYRADEVERILRTALRLAGQR-RG 200 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L TK G+ W + + A+A + +R +D + + P +FDV+V N Sbjct: 201 DLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPN 260 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDIL D G G+ G++ S N ++++ HG+A D+ G++ ANPI + + Sbjct: 261 MFGDILGDCGSLLMGSRGMSWSGNYGA--AGQAVYQTAHGAAWDLAGRDRANPIGQVCSL 318 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAICKII 359 AMML R + + AI +A G +T D++G T + A+C + Sbjct: 319 AMMLR----ESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQALCASL 373 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 273 bits (699), Expect = 5e-72, Method: Composition-based stats. Identities = 78/359 (21%), Positives = 160/359 (44%), Gaps = 37/359 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 KT ++ I G+G+G+E++ V+ A + ++ + E+ + + + Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEV 136 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L G V + R++F Q+ + G+ P Sbjct: 137 LKSLRANKVGIKGPVDSRHWQR----------QIRKQFAQFAYVSLCSHIEGLDSPY--- 183 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 GD D ++R+ EG+YS + V G V+ V T G RI + F A Sbjct: 184 --GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNK 237 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T A K+N + ++ + E + A A+ + ++ ++++++D + +++P + DV+V Sbjct: 238 RKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMV 297 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +S+++GD+L + G GI P +++ T +F+ + + GK++ANP + Sbjct: 298 SSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT---VFDCRMKACHALAGKDLANPTGPL 354 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + A+ML + + + + + AI +V +TPD+ G A + A+C + Sbjct: 355 LSAALMLRHV-----KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 117/376 (31%), Positives = 175/376 (46%), Gaps = 29/376 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IA IP DG+GK+V+P G + +Q A E GF L E A EY GKM D Sbjct: 1 MKKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE-AGVEYAVKTGKMCED 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + E +++ DA+ G+ G D P + + L R + LRP+RL G Sbjct: 60 NLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + CPL +ID +VR+ EG Y G + + V TR ++ Sbjct: 120 IDCPLRN--REEIDVLLVRQLAEGFYIRPGHMIG----EDAAYDTIVVTRNVTEKFADTC 173 Query: 175 FELAQSR------PRKTLTSATK-SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 F LA+ R +K +T K N ++ + ++ YP+I +D L Sbjct: 174 FRLARGRHGRRQDGKKMVTLGNKHGNV--TCFDFYRKIFTEVSAGYPDIGLQFTQVDALA 231 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P+RFDV+ N+ GDI+ D+G TG +GI P+A++ F P HG+ P Sbjct: 232 EHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVG---GVTPQFRPNHGTFP 288 Query: 288 DIYGKNIANPIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAH-GPKTPDMKG 344 GK ANP+A+I ++LD LG GD+ ++ I A+E + GP+T D+ G Sbjct: 289 RAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGG 348 Query: 345 NATTPQVADAICKIIL 360 A T A+A+ K + Sbjct: 349 TANTFATAEAVFKAME 364 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 271 bits (692), Expect = 4e-71, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 112/258 (43%), Gaps = 31/258 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ I GDG G E+ RVL+A G A ++ + A + G +PD E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA----TGVAFDWDIQD-AGVDVMEQLGTPLPDSVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + P + R+E D Y +RP R +PGV + Sbjct: 58 SIRSTKVALKAPITTP----VGTGFRSVNVAIRKELDLYACVRPCRSYPGVRS-----RF 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-----------------VIQESVFTRRGV 167 +ID VVRENTE Y+ + E+ I + G Sbjct: 109 ENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGS 168 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 +RI+R+AFE A++ RK +T+ K+N + S + E +A+ YP+I +D + +D +C Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMC 228 Query: 228 ARFVMQPERFDVVVASNL 245 + V +PE +DV+V NL Sbjct: 229 MQLVQKPELYDVMVLPNL 246 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 270 bits (691), Expect = 5e-71, Method: Composition-based stats. Identities = 111/374 (29%), Positives = 158/374 (42%), Gaps = 73/374 (19%) Query: 1 MM-KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M +T+RI IPGDGIGKEV+P G R+L+A G F + A E + G +P Sbjct: 1 MSIRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLH-AGFETFERTGAALP 59 Query: 60 DDWHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 D E L D FGAV P + ++ R++ D Y N+RPV+ P Sbjct: 60 DKTVEILRNECDGALFGAVSSPSS--PVKGYSSPIVALRKKLDLYANVRPVKTVLSAAKP 117 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 ID +VRENTE Y + V + R RI A ++A Sbjct: 118 --------IDMVIVRENTEDLYVKEETTRDTPDGK-VAEAIKRISERASHRIATMAGDIA 168 Query: 179 QSRPRKT------------LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 R + +T KSN L + Sbjct: 169 LRRQKIRAAGAPSIHQSPLVTITHKSNVL-----LRLK---------------------- 201 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 +V+V NL+GDILSD A G++G+ PSAN+ ++ EP HGSA Sbjct: 202 -----------NVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE---GFAIGEPCHGSA 247 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGN 345 PDI G+NIANPIAT+ + A+ML+FL + ++ + G +PD+ G Sbjct: 248 PDIMGQNIANPIATLRSAALMLEFLDEEAAAAKIYAA-----VDANLTEGKLLSPDLGGT 302 Query: 346 ATTPQVADAICKII 359 A T +V + I + + Sbjct: 303 AKTTEVIEDILRRL 316 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 269 bits (689), Expect = 8e-71, Method: Composition-based stats. Identities = 97/463 (20%), Positives = 151/463 (32%), Gaps = 120/463 (25%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSF--EQMEWASCEYYSHHGKM-- 57 I I GDG G ++ P V+ AA + +A E +G Sbjct: 24 PNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQI 83 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 P+D + + G + P + + R+ FD Y +RP R +PG P Sbjct: 84 FPEDTLTAIKEYGVAIKGPLTTP----VGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPS 139 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------ 153 P P +D V RENTE Y + Sbjct: 140 PHK--TPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRL 197 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA- 210 + I ++ G R++R A A+ P+ +T K N + + + + +A Sbjct: 198 DSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELAT 257 Query: 211 -------------------ENYPE--IRWDKQHID-----------ILCARFVMQP---- 234 E+ P+ I + ID + + V Q Sbjct: 258 TEFRAECVTERESWICGNKESNPDLTIEANAHMIDPGYDTLTEEKQAVIKQEVEQVLNSI 317 Query: 235 --------ERFDVVV-----------------------ASNLFGDILSDLGPACTGTIGI 263 + V+V NL GD LSD A G +G+ Sbjct: 318 WESHGNGQWKEKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGM 377 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 P AN+ ++FE HG+AP G + NP + I +G MML+F+G +Q+A + Sbjct: 378 GPGANIGDSA---AIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMG-----WQEAAD 429 Query: 324 GILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKI 358 I I IA+ T D+ + A AI Sbjct: 430 LIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 265 bits (678), Expect = 2e-69, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 143/360 (39%), Gaps = 30/360 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M I + GDGI +E+ V A F + F ++ S E G + D+ Sbjct: 6 MNRYSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDL-SDESREAKGDAIYDE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + R+ R + V RPV PG+ Sbjct: 61 AEAAMRRYGTSLKYPTATTK--------ESPNRVLRERCNFAVIHRPVATIPGIQTHYN- 111 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 I +VR T G Y G R+N + + RR R+AF LAQ R Sbjct: 112 ---ERIHLDIVRIATGGTYEDAGRRINR----DTAVSIRAIERRPSVLASRFAFRLAQLR 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + + +K + + E +A +YP + ++ D L A +M+PER+ V+V Sbjct: 165 D-SNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTF---PSLFEPVHGSAPDIYGKNIANPI 298 N +GD LSD+ G+IG+ SA+ + + ++F+P G+APDI G+N ANP Sbjct: 224 CPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPT 283 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A + A A ML +G D + A+ I G KT D+ G+ + I Sbjct: 284 AALLAMANMLRHIGEHDS-----SKALRGALFGAIEAGEKTADIGGSLNLSEFTQVIVDR 338 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 261 bits (666), Expect = 4e-68, Method: Composition-based stats. Identities = 101/368 (27%), Positives = 143/368 (38%), Gaps = 45/368 (12%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF--ALSFEQMEWASCEYYSHHGKMMP 59 M T I GD G EV+ E ++VL+A + ++ H + Sbjct: 1 MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGAS-IKVHNDPLT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHI-SLWGSLLKFRREFDQYVNLRPVRLFPGV--- 115 DAI GA+G P+ P LL+ R+E Y NLRP Sbjct: 60 AKALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVD 119 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 PL DF VVRE T G Y E + ++R ++RI R A Sbjct: 120 SSPLKADVCRGTDFIVVRELTGGIYFGA---RTEDDGSGFAMDTDAYSRAEIERIARLAG 176 Query: 176 ELAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 LA + P + S K+N LA S + E A +P++ Q ID V P Sbjct: 177 FLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSP 236 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 + VVV SNLFGDI+SD G+I G Sbjct: 237 RALNGVVVTSNLFGDIISDEASVIPGSI-----------------------------GAG 267 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVAD 353 I NPI TI + AMML + + + AA+ + +G +T D+ G+A T Q+AD Sbjct: 268 IVNPIGTILSVAMMLRY----SLNLPKEAAAVEAAVRTALDNGTRTKDLGGSAGTFQMAD 323 Query: 354 AICKIILR 361 A+ +++ Sbjct: 324 AVVVELVK 331 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 259 bits (663), Expect = 1e-67, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 145/370 (39%), Gaps = 34/370 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +R+ I G G G VL ++ +AA + ++ + + + + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAAL----VPVEWDYQTLSVYRDHKTNRMTVNPQL 94 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + P SL L + + +V +R G + Sbjct: 95 LDSAIETGLVLCAKDSSPRQND---SLESDSLALHKALNAFVGVRKFNSVVG------HE 145 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 G I+ +RE+ GEYS + V+ G VV +++ + + AF+ A Sbjct: 146 PYGPINLVNIREHVSGEYSEIEHLVSPG----VVQSIKTVSKKISVEVAKLAFDYACKHG 201 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +T K++ + +S + + ++ YP++ ++++ +D C P R++V++ Sbjct: 202 HSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRYEVLLT 261 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP------VHGSAPDIYGK---- 292 ++L+G + +G + P+ P+ T S H I+ K Sbjct: 262 TSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYG 321 Query: 293 --NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 I NP I A A+MLD G A I AA+E+ I G +T DM G+A+ Q Sbjct: 322 QEQIINPTGIIRAAALMLDHAG-----MVVAGRCIAAAVEDTIRQGIRTQDMGGDASCSQ 376 Query: 351 VADAICKIIL 360 DAI K + Sbjct: 377 FTDAIIKNLK 386 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 110/346 (31%), Positives = 172/346 (49%), Gaps = 47/346 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A IPGDGIG+E++P AAA ++F + +S E Y G ++ DD E+L Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDISS-ERYIKTGIIIKDDELEEL 57 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + AI FGA+G P P I G +L+ RRE + Y+N+RPVR F Sbjct: 58 KNYRAILFGAIGDPRVRPG-IMEQGVILRLRRELELYMNIRPVRSFDD-----------K 105 Query: 127 IDFYVVRENTEGEYSSLGG---------------RVNEGTEHEVVIQESVFTRRGVDRIL 171 I ++RENT+ Y+ + G ++ + EV + + R + + Sbjct: 106 IKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFF 165 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 AF + T+T K+N + + W A I ++ D L + Sbjct: 166 NKAFSIC----DSTVTVTDKANAVKMYN-LWRSTAMEAAIE-KNINISFEYADALAYNMI 219 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + P+++ ++A NL+GDI+SD+G A G +G APSAN+ + +LFEPVHGSAPDI G Sbjct: 220 LNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDK---NALFEPVHGSAPDIAG 276 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 +++ANP A+I AG+M+L++LG DE I + + +G Sbjct: 277 RDMANPAASIMAGSMLLEYLGYRDE-----SRIINDMVRNLYINGV 317 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 257 bits (658), Expect = 3e-67, Method: Composition-based stats. Identities = 92/362 (25%), Positives = 147/362 (40%), Gaps = 17/362 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 T I + GD G+E+L + +RVLQ + R L F + S E + + Sbjct: 4 TTPTIVVMHGDQTGEELLIQALRVLQPSVIR--QPLQFLDYDL-SLENRRATDNKVVWEA 60 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A P+ D R + V LR R P + P+AG Sbjct: 61 AQAARDSGLSLKAATITPEIAGDVG---SPNAILREALNAKVILRTGRRIPKI-RPIAGV 116 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +VR + Y S R E+ + S +R + + F+ A R Sbjct: 117 YSP---IAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFTFQYA-KRT 172 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 + + K A + E ++A A+ YPE+ + ID A + V+ A Sbjct: 173 KAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTGESLVIPA 232 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPI 298 N GD+LSD+ G+I + S L ++ + E HG+AP ++GKNIANP+ Sbjct: 233 LNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPM 292 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A I AGA +L + + ++A I ++ E I G TPD+ G TT + D + + Sbjct: 293 AMILAGAALLSY--GRIPQAEKASRAIYESVFETIYEGKATPDLGGQMTTSEFTDEVIRR 350 Query: 359 IL 360 + Sbjct: 351 VE 352 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 125/337 (37%), Positives = 169/337 (50%), Gaps = 52/337 (15%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IAAI GDGIG EV+ G + A ++ W + S Sbjct: 16 YKIAAIRGDGIGPEVIEAG---------NYQSAEETNRVAWILLNWPSRT---------- 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLR------PVRLFPGVPCP 118 GAV D + S + F Y+ LR P R+F G+ P Sbjct: 57 --------LSGAVRITRNTADISPISSSTFLW---FSSYLPLRSSTSNMPTRVFHGIQSP 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D+ +VREN+EGEY+ GGR G EV S+FTR GV+RI+++AFE A Sbjct: 106 L------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAA 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVE-AMAENYPEIRWDKQHIDILCARFVMQPERF 237 +SR +K +T ATKSN + WDE +A +P++ DK +D + AR V+ PE Sbjct: 160 RSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPESL 219 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +NL ILSDL A G+IGIAP++NL+P R PS+FEPVHGSA DI GK++A Sbjct: 220 DTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA-- 277 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 T W A ML +LG A +L +E V Sbjct: 278 --TFWTVAEMLSWLGQKG-----AAAELLECVESVCK 307 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 252 bits (643), Expect = 2e-65, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 152/365 (41%), Gaps = 17/365 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++I + GD G+E+L + +RVL E G L E+ + S E + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDL-SLENRRATQNGVVS 57 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D + A P+ D R E D V +R R PGV P+A Sbjct: 58 DAAAAMRTCGFGIKAATITPEGADDVG---SPNRILREEVDGKVIVRTGRRIPGV-TPIA 113 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +VR E Y + R + G EV + TR + YAF A+ Sbjct: 114 GVHYP---ISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEYAFRTAR 170 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QPERFD 238 + + K + E ++A A +P++ ++ ID A V + Sbjct: 171 AMQ-ARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGAADEPL 229 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNIA 295 VV A N GD LSDL G+I A S L + T ++ E HG+AP + GK++A Sbjct: 230 VVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVA 289 Query: 296 NPIATIWAGAMMLDFLGNG-DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NP+A + A +L ++A I ++ E IA G KTPD+ G+A T + DA Sbjct: 290 NPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTDA 349 Query: 355 ICKII 359 + + I Sbjct: 350 VIERI 354 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 248 bits (633), Expect = 3e-64, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 147/342 (42%), Gaps = 37/342 (10%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + V+ A + ++ + E+ + + + + L G V Sbjct: 1 MDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS 52 Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 + R++F Q+ + G+ P GD D ++R+ EG+ Sbjct: 53 RHWQR----------QIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGD 97 Query: 140 YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 YS + V G V+ V T G RI + F A RK +T A K+N + ++ Sbjct: 98 YSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTD 153 Query: 200 PYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + E + A A+ + ++ ++++++D + +++P + DV+V+S+++GD+L + Sbjct: 154 GNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMM 213 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G GI P +++ T +F+ + + GK++ANP + + A+ML + + Sbjct: 214 GVPGICPGYSVSSLGT---VFDCRMKACHALAGKDLANPTGPLLSAALMLRHV-----KM 265 Query: 319 QQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + + + AI +V +TPD+ G A + A+C + Sbjct: 266 DKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 246 bits (629), Expect = 8e-64, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 143/327 (43%), Gaps = 35/327 (10%) Query: 19 VLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVG 78 ++ ++V + ++ + S G+ + E L R G Sbjct: 1 MIESLVKVFSTVQ----VPIDWDVFH--EHKINSAEGEDVSPKLLESLCRNKIGIKGPFE 54 Query: 79 WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEG 138 L K R++F + + R G + G +D ++R+ EG Sbjct: 55 SGPC----------LRKLRKKFQLFAFVAVCRNLEG-----QNTRYGKLDCLIIRDQVEG 99 Query: 139 EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAIS 198 EYS + RV G V+ V T G DR+ RY FE A+ RK +T A K+N + ++ Sbjct: 100 EYSGIEHRVVPG----VMQTIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLT 155 Query: 199 MPYWDERVEAMAENYP-EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + + A Y +I ++++++D +C +M+PER DV+VAS+++GD+L+ + + Sbjct: 156 DGTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASI 215 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDER 317 G + P + P ++EP+ + +I GK+I NP + +G +ML + + Sbjct: 216 MGGPALCPGFAVGPMGL---IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLR-----EMK 267 Query: 318 FQQAHNGILAAIEEVIAH-GPKTPDMK 343 + + I A+ V +T D+ Sbjct: 268 LNEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 237 bits (605), Expect = 5e-61, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 145/342 (42%), Gaps = 45/342 (13%) Query: 18 EVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAV 77 E+ + LQ A G ++++ ++ ++P+ + + G + Sbjct: 12 ELGAQVTNALQMAIAATGVDITWQIVDIGG----EDQQGLLPNYIFDIIRTAKTAVIGPL 67 Query: 78 GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE 137 PD + R + D YVNLRP + G+P ++D +VRE TE Sbjct: 68 MMPD------NYRQMEADIREKLDLYVNLRPAKTMVGIPSNY-----QNVDIMIVRETTE 116 Query: 138 GEYSSLGGR----------------VNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G Y+ + + + + + +G +I+ +AF A+ Sbjct: 117 GIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKT 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R + + +++ +A + + E +A+ +P+I + + I+++C + +PERFDV+V Sbjct: 177 KRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GD+L+ L G + + P A++ + + D G + P + I Sbjct: 237 MPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVFG----AQSTGTDDVGHD---PTSLI 288 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM 342 AGA+ML LG Q+A + AA+E V+A T D+ Sbjct: 289 LAGALMLRHLGE-----QEAAQRLQAAVEAVVASHVDTTADL 325 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 235 bits (601), Expect = 2e-60, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 122/416 (29%), Gaps = 67/416 (16%) Query: 3 KTMRIA--AIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++A + D G E+ + ++ + + + + Sbjct: 42 KRIKVAKPVVEMD--GDEMTRIIWQFIKEKLILPHVDIQLKYFDL-GLPNRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D ++ A PD R V P+ + + Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPI-ICKNI 157 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQES--------------- 160 P + G + R +Y + + ++V Sbjct: 158 PRLVPGWTKP---ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA 214 Query: 161 -------VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 T + F+ A + L +TK+ L + + + + ++ Sbjct: 215 GGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEIFDKH 273 Query: 213 YP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y +I ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 274 YKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTS 332 Query: 267 ANLNPERTFPSLFEPVHGSAPDIY---GKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K NPIA+I+A L+ G D + Sbjct: 333 VLVCPDGKTI-EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 391 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGN-------------ATTPQVADAICKIILR 361 + + E + G T D+ G T D I + R Sbjct: 392 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDR 447 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 234 bits (596), Expect = 5e-60, Method: Composition-based stats. Identities = 109/351 (31%), Positives = 162/351 (46%), Gaps = 21/351 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T R+ G+GIG E++ ++ ++ A + G A E + G+++P++ Sbjct: 5 ETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEET 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E ++ D G P R++ D + N+RPVR PG Sbjct: 65 WETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPG-------A 117 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQ 179 D+D +VRENTEG Y+ + G EV + VFT+ + RI+R A Sbjct: 118 VHPDLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRA-AAIA 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + LT A KSN L + + +A AE + + HID LCA V +PER+ Sbjct: 177 AARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTRPERYAT 235 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +VA N+FGDILSDL G++GIA S N + + + + HGSAPDI G+ IANP Sbjct: 236 IVAENMFGDILSDLAGGLGGSLGIAGSINASESQ---VMAQAAHGSAPDIAGQGIANPAG 292 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 + + A MLD LG QA + A+ E + P T D+ A Sbjct: 293 IMNSAAQMLDSLGY-----PQAAELLEGAVREAVVKAP-TADLVREAAAAD 337 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 230 bits (588), Expect = 5e-59, Method: Composition-based stats. Identities = 97/364 (26%), Positives = 146/364 (40%), Gaps = 31/364 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +R+A +PGDG+G+EVL R+L+ AER ++ + G ++P Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTGPWP--VGARAAAETGDVLPAGTLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDH--ISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI GAVG VP +L + R +D +++R + G Sbjct: 60 ACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGRE------ 113 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 VVR G Y RV E TR V ++ A ++ R Sbjct: 114 ------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLGRRG 166 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L S K+N L + W + +A I + +++D DV+V Sbjct: 167 GGRLVSVDKAN-LYATGRLWRQVAGDVARE-RGIEVEHRYVDRAAFELGSGAPVPDVLVT 224 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGKNIANPI 298 L GDILSDL G+ + SA+L+P LFEP HGSAP ++ +P+ Sbjct: 225 EGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPL 284 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 A A +L ++A + AA+ V+ GP T D+ A+T QVADA Sbjct: 285 GGFLALAALLRHF----PATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVADA 340 Query: 355 ICKI 358 + Sbjct: 341 VLAA 344 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 230 bits (588), Expect = 5e-59, Method: Composition-based stats. Identities = 75/359 (20%), Positives = 127/359 (35%), Gaps = 31/359 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + ++A +PGDG G + R L R + + ++ + G +P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---PCP 118 + DA+ G P I LL R+E + VN+RPVR Sbjct: 68 TLGACRQSDAVLVCGCGDPRYG---IEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + +D R+ T G Y + E + ++R+ ++RI R A A Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGE---AYDTTPYSRQTIERIARLAGTYA 181 Query: 179 QS-RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 P K + S K N +A S + +P++ +D P Sbjct: 182 MQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDPLSL 241 Query: 238 D-VVVASNLFGDILSDLGPACTGTIGIAPSANL-----NPERTFPSLFEPVHGSAPDIYG 291 + +++ N+FGDILSD G+ + SA + R P +FEP + + G Sbjct: 242 NGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNP----G 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA------HGPKTPDMKG 344 P+ +I A +ML+ + AI + +T D+ G Sbjct: 298 GKTVGPLGSIQAVGLMLE----LSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 227 bits (580), Expect = 4e-58, Method: Composition-based stats. Identities = 65/418 (15%), Positives = 118/418 (28%), Gaps = 69/418 (16%) Query: 2 MKTMRIAA----IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M +I + D G E+ + ++ L + + Sbjct: 1 MAFQKITVQNPIVEMD--GDEMTRVIWKSIKDKLILPFLELDIKYFSL-GLPHRDATDDK 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLF 112 + + E +++ A PD R + V P+ + Sbjct: 58 VTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPI-MC 116 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSL-----------------------GGRVNE 149 +P + G + R +Y + V Sbjct: 117 KNIPRLVPGWTKP---ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYN 173 Query: 150 GTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 T V T V + +A + L +TK+ L + + + + Sbjct: 174 FTGAGGVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKDIFQEV 232 Query: 210 AE-------NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 E I ++ + ID + A + + V N GD+ SD G++G Sbjct: 233 YEANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLG 291 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY------GKNIANPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ N IA+I+A L D Sbjct: 292 LMTSVLVCPDGKTI-EAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDN 350 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMK-----GN-------ATTPQVADAICKIIL 360 ER + AA + G T D+ G+ T + DA+ + Sbjct: 351 NERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELK 408 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 66/418 (15%), Positives = 128/418 (30%), Gaps = 70/418 (16%) Query: 1 MMKTMR---IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M K + + + GD E+ +++ L + E Sbjct: 1 MSKKISGGSVVEMQGD----EMTRIIWELIKEKLIFPYVELDLHSYDL-GIENRDATNDQ 55 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLF 112 + D E + + + A PD R V R + Sbjct: 56 VTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVF-REAIIC 114 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR------- 165 +P ++G + R +Y + V + E+ S T++ Sbjct: 115 KNIPRLVSGWVKP---IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHN 171 Query: 166 ----------------GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 ++ +F++A S+ L +TK+ L + + + + Sbjct: 172 FEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEI 230 Query: 210 -AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + Y +I ++ + ID + A+ + F + N GD+ SD G++G Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLG 289 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ + NPIA+I+A L D Sbjct: 290 MMTSVLVCPDGKTV-EAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDN 348 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMKG------------NATTPQVADAICKIIL 360 + N + E I G T D+ T + D + + + Sbjct: 349 NKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 222 bits (566), Expect = 2e-56, Method: Composition-based stats. Identities = 66/415 (15%), Positives = 126/415 (30%), Gaps = 67/415 (16%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 + +++ + D G E+ +++ + + S ++ + Sbjct: 180 QRIKVDQPVVEMD--GDEMARVIWAMIKEKLILPYLDIPLMYYDL-SIQHRDKTDDQVTI 236 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D + R A PD R D + P+ L V Sbjct: 237 DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPI-LMKNV 295 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLG-----------------------GRVNEGTE 152 P + + R +Y +L V E Sbjct: 296 PRLVPSWTKP---IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKG 352 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AE 211 V + T + F+ A + + L +TK+ L + + + + + Sbjct: 353 GGVALG-MYNTDASIKGFAHSCFQYALDQ-KMPLYLSTKNTVLKKYDGRFKDIFQTIYEK 410 Query: 212 NYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 Y + ++ + ID + A+ + F V N GD+ SD+ G++G+ Sbjct: 411 EYKQKFEEAGLWYEHRLIDDMVAQAIKSSGGF-VWACKNYDGDVQSDVVAQGYGSLGLMT 469 Query: 266 SANLNPERTFPSLFEPVHGSAPDI---YGKNI---ANPIATIWAGAMMLDFLGNGD--ER 317 S + P+ E HG+ Y K I NPIA+I+A L D ++ Sbjct: 470 SVLVCPDGKTI-EAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQK 528 Query: 318 FQQAHNGILAAIEEVIAHGPKTPDM-----KGNAT------TPQVADAICKIILR 361 ++ + A E + G T D+ T T D + ++ R Sbjct: 529 LKEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRDYLCTEDFMDKLARVAER 583 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 68/378 (17%), Positives = 130/378 (34%), Gaps = 44/378 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 + I I GDGIG E+ I V+ +A E G E Y G +P Sbjct: 21 PDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVP 80 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 +D +++ + + +PD R+ Y N+R ++ G+ P+ Sbjct: 81 EDSIKEIQKMYIAMK---STLNFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMDIPV 134 Query: 120 AGKQPGDIDFYVVR-------------ENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRG 166 ++ ++R E+T+ + + I ++ Sbjct: 135 N--TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFR 192 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +I + A ++ +K +T + + A ++ ++ Sbjct: 193 TRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEASAQEDVGYEVLKTREF 247 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 R + PE F+V++ N+ L D GTI I +++ E ++FE V S Sbjct: 248 MKRLISSPEDFEVILVDNVLSQTLVDYLA---GTINIEYGSSIGDE---CAVFEAVQSSL 301 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK--- 343 P G + A+P++ I +G ML +G + +A I AI D+ Sbjct: 302 PSEAGYDAADPLSFILSGCEMLMHIG-----WVEAAQIIENAISAAFRDNKIPKDINTRP 356 Query: 344 --GNATTPQVADAICKII 359 + + I K + Sbjct: 357 DISPIKCSEFSSEIIKRM 374 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 90/255 (35%), Positives = 125/255 (49%), Gaps = 19/255 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG E++ + VL+AAA R L F + A + + G M E++ Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSED-AGADAFRRTGSAMSAATLERI 66 Query: 67 S-RFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 R+ + G VG P PD R D Y N+RP+ L PGV PL G Sbjct: 67 RTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTA- 125 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVI-QESVFTRRGVDRILRYAFELAQSR-- 181 +D+ +VRENTEG Y S G ++ + + TR GV+R++ +AFELA R Sbjct: 126 --VDYVIVRENTEGLYLSR----GRGVGNDRACADQLLMTRHGVERVVVHAFELATRRTG 179 Query: 182 ----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + +T KSN L S ++ E + +A YP++ D ++ D V P RF Sbjct: 180 APADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRF 238 Query: 238 DVVVASNLFGDILSD 252 DV+V N GDILSD Sbjct: 239 DVLVMENFLGDILSD 253 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 212 bits (540), Expect = 2e-53, Method: Composition-based stats. Identities = 65/386 (16%), Positives = 129/386 (33%), Gaps = 50/386 (12%) Query: 2 MKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M +++ + D G E+ +V++ + + + EY + Sbjct: 7 MNKIKVKNPVVELD--GDEMTRIIWQVIKDKFIHPYLDIDLKYYDL-GLEYRDETNDQVT 63 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPG 114 D E + ++ A PD R V P+ + P Sbjct: 64 LDAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPA 122 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 +P + + + R +Y + ++ E+V + V ++ + Sbjct: 123 IPRLVPSWKQP---IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKG-GKPEVIKVYDFP 178 Query: 175 FE--LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 E +AQ++ K I + + EA I ++ + ID + A+ + Sbjct: 179 AEGGVAQTQF--------KDIFQEIYEAQYRKEFEA-----AGIWYEHRLIDDMVAQMIK 225 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-- 290 + ++ N GD+ SD+ G++G+ S + P+ E HG+ Y Sbjct: 226 SEGGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTF-EAEAAHGTVTRHYRE 283 Query: 291 ---GKNIA-NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVI-AHGPKTPDMK 343 G+ + NPIA+I+A L G D + A + + G T D+ Sbjct: 284 HQKGRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLA 343 Query: 344 ---GN------ATTPQVADAICKIIL 360 G TT + DA+ + + Sbjct: 344 LAQGKKDRSAWVTTNEYLDAVERRLK 369 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 212 bits (540), Expect = 2e-53, Method: Composition-based stats. Identities = 62/377 (16%), Positives = 116/377 (30%), Gaps = 59/377 (15%) Query: 36 FALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLW 90 + EY + + E + ++ A PD Sbjct: 90 IPIQLPGHRPQGIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWL 149 Query: 91 GSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEG 150 R V P+ + P +P + G + R +Y + + Sbjct: 150 SPNGTIRNILGGTVFREPI-VIPAIPRLVPGWTKP---IIIGRHAFGDQYRATDRVIPGP 205 Query: 151 TEHEVVIQ----------------------ESVFTRRGVDRILRYAFELAQSRPRKTLTS 188 + E+V T + +F++A + L Sbjct: 206 GKLELVYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYM 264 Query: 189 ATKSNGLAISMPYWDERVEAM-AENY------PEIRWDKQHIDILCARFVMQPERFDVVV 241 +TK+ L + + + + Y I ++ + ID + A+ + F ++ Sbjct: 265 STKNTILKRYDGRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMA 323 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA- 295 N GD+ SD+ G++G+ S P+ + E HG+ Y G+ + Sbjct: 324 LKNYDGDVQSDIVAQGFGSLGLMTSTLTTPDGSAFES-EAAHGTVTRHYREHQKGRETST 382 Query: 296 NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVI-AHGPKTPDMK---GN---- 345 NPIA+I+A L G D + A EV+ G T D+ G Sbjct: 383 NPIASIFAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKERE 442 Query: 346 --ATTPQVADAICKIIL 360 TT + A+ + + Sbjct: 443 AWVTTREYMAAVERRLK 459 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 205 bits (523), Expect = 2e-51, Method: Composition-based stats. Identities = 69/361 (19%), Positives = 126/361 (34%), Gaps = 68/361 (18%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + + I V +V+ A + FE + + Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQA----PVYFETYIIKG-----KNMNHLTW 44 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + + + G V R+E D + +L G P Sbjct: 45 EVVDSIRKNKVCLNGRVNNSLCGGA-----------RKELDLFASLVDCFNLNGQPS--- 90 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + ++D V+RENTEGEY+ V G + T+ DRI +YAFE A Sbjct: 91 --RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVTM---TKFWSDRIAKYAFEYAHF 145 Query: 181 RPRKTLTSATKSNGL-AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 RK +T+ + ++ ++ E + +A+ YP I +++ +R R Sbjct: 146 SKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEI-----ASRETRAIRRHS- 199 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 S I++++ G + + ++FE V N NP+A Sbjct: 200 --NSKSLWAIIANIASGVAGG-------SFGDDY---AIFEQVGSVG------NHKNPVA 241 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +++ MML L + + A+ VI+ G N TT +V D++ + Sbjct: 242 LLFSSVMMLRHL-----LLPLFADRLKTAVTRVISEGKCG---NSNTTTQEVVDSVIANL 293 Query: 360 L 360 Sbjct: 294 D 294 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 89/165 (53%), Gaps = 9/165 (5%) Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 +S + V MA+ +PEI+++++++D +C V P ++DV+V NL+GDILSD+ Sbjct: 112 RMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 171 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 G +G+ PS N+ +LFE VHG+APDI GK++ANP A + + MML + Sbjct: 172 GLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM---- 224 Query: 316 ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + I A E I G T D+ G A + + IC + Sbjct: 225 -ELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 268 Score = 53.0 bits (126), Expect = 2e-05, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 21/42 (50%), Gaps = 4/42 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW 45 T ++ IPGDGIG E+ ++ AA + +E ++ Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDV 84 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 196 bits (499), Expect = 9e-49, Method: Composition-based stats. Identities = 73/371 (19%), Positives = 137/371 (36%), Gaps = 34/371 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS----HHGKM 57 M ++++ G+G G E+ RV+Q+ A R+ +++F + Y S + Sbjct: 1 MSSIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADA 60 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 + ++ + + AV S+ L RE Q + + L P Sbjct: 61 VTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQAIKVEHFTLSPTSS- 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 +VR+ +G YS + T + V + + F++ RIL YA Sbjct: 120 -----------ILLVRDQAQGFYSGTN---SVNTSKDAVSRTAHFSKAIFARILSYALGR 165 Query: 178 AQSR--PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QP 234 A ++T K + + + + D + + Sbjct: 166 ANQLWGGTNSVTMVYKFHLF---DGLFHTWATEWERTF-GVNIRFVQGDTMNRDLLAFGV 221 Query: 235 ERFDVVVASNLFGDILSDLGPACTG----TIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 +++++ N + DI+ + G A + L+P+ S ++ HGSA D+ Sbjct: 222 SGHNLLISGNEYADIMQTILLDRFGLGAQESACAENVYLHPDVQGLSEYQTAHGSADDLL 281 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP ATI A A +L+ + + ++ A G TPD G ATT + Sbjct: 282 GKGIVNPTATIRAAAAVLEDQAGCSG----LKQRVDCVLGDLGARGIGTPDQGGTATTER 337 Query: 351 VADAICKIILR 361 +A + + + Sbjct: 338 FVEAFLQGLDQ 348 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 111/301 (36%), Gaps = 19/301 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E ++++ +K + D Y+ VR FPG Sbjct: 93 DPLETDDFYNSVLRNRSAVHVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGF----- 147 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + D++ ++ +N G YS L +G VV SV T+ G ++ LR AF A Sbjct: 148 NCRFPDVNIRIIAQNNMGVYSDLEYSPVKG----VVEAISVSTQEGNEKYLRKAFATAVK 203 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDV 239 RK +T KS I+ + + ++Y + + +++ R + P+ FD Sbjct: 204 ANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHCLELELMNVEDCIGRLITHPQEFDC 263 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + +S+ + +++ + G + + + ++F+P+ + I +P Sbjct: 264 IFSSDRYATMIATMCSGICGGANLFSAVEIGDFH---AVFKPLQ-VKLSLTNYPILSPYG 319 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + D LG + + + + + G KT D G + V I + Sbjct: 320 IVNTIVDLFDHLGYT-----ECGDALWEQMLRTMESGIKTKDFGGEDSGEYVICNIINRL 374 Query: 360 L 360 Sbjct: 375 R 375 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 55/407 (13%), Positives = 118/407 (28%), Gaps = 73/407 (17%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 +++ + D G E+ R+++ L + + + Sbjct: 79 DRVKVQNPIVEMD--GDEMTRVIWRMIKDKLIFPYLDLDIKYFDL-GILNRDATDDKVTV 135 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + E +++ A PD R + V P+ + Sbjct: 136 ESAEATLKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCL-NI 194 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------- 155 P + G + + R +Y + + + ++ Sbjct: 195 PRIVPGWKKP---ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKG 251 Query: 156 -VIQESVFTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN- 212 + +++ R + LA + + L +TK+ L + + + + E Sbjct: 252 PGVALAMYNVDQSIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEEK 310 Query: 213 ----YPE--IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 + E I ++ + ID + A V + V N GD+ SD + Sbjct: 311 WKQKFEEHSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEAE 362 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD--ERFQQAHNG 324 A LF+ ++ N IA+I+A L+ D E + Sbjct: 363 AAHGTVTRHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVHK 414 Query: 325 ILAAIEEVIAHGPKTPDMK----GN-------ATTPQVADAICKIIL 360 + + E + G T D+ G T + DA+ + + Sbjct: 415 LEGSCIETVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLE 461 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 194 bits (493), Expect = 4e-48, Method: Composition-based stats. Identities = 67/410 (16%), Positives = 120/410 (29%), Gaps = 61/410 (14%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M K M + D G E+ ++++ L E + + + Sbjct: 33 MTKIQMTTPLVEMD--GDEMTRIMWQMIKDELICPFVDLKTEYYDL-GLAHRDETDDQVT 89 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPG 114 D E R A P+ R D V P+ + G Sbjct: 90 VDSAEATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPI-VVRG 148 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ----------ESVFTR 164 + + + R Y R+ E+V FT Sbjct: 149 IDPCVKNWVRP---ITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTE 205 Query: 165 RG-----------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM---- 209 G ++ R F+ A + + + ATK + + + + Sbjct: 206 PGVVEGMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDAD 264 Query: 210 -AENYP--EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 A + I + ID AR + F + N GD++SD+ + G++ + S Sbjct: 265 YAARFEAAGIEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAMMTS 323 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKNIA------NPIATIWAGAMMLDFLGNGD--ERF 318 +P + +E HG+ Y K++A N +ATI+A L D Sbjct: 324 VLASPHGYW--EYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLADL 381 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKIIL 360 + + A I G T D+ +T A+ + + Sbjct: 382 AAFADALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDLK 431 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 189 bits (481), Expect = 1e-46, Method: Composition-based stats. Identities = 72/377 (19%), Positives = 133/377 (35%), Gaps = 43/377 (11%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY--------SHH 54 +T+R+ G G G+E++ RV+Q A+++ F + Y+ + Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVRSSSTYHSYHTLTVSGEDKNL 63 Query: 55 GKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + D+ + + A G ++ L R+ Q + L G Sbjct: 64 ITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYLVRQHLQAAKVEHFSLGDG 123 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 +VR+ +G Y+ + + + + F++ DRI+R+A Sbjct: 124 NA------------LLMVRDEAQGFYAG---DNTYSADQLSITRTTSFSKPVFDRIIRFA 168 Query: 175 FELAQSR-----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 + A K +T A K + + + I +D D L Sbjct: 169 LDRAAENWGPENVPKKVTMAYKFHLF---DGVFQAWEPQWKAQF-GIDFDFIQPDTLNRS 224 Query: 230 FVMQ-PERFDVVVASNLFGDILSDLGPACTGTIG----IAPSANLNPERTFPSLFEPVHG 284 + + +++A N + D++ + G A + L P+ S ++ VHG Sbjct: 225 LMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETMYAENVYLRPDVNGLSEYQTVHG 284 Query: 285 SAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 SA I K + NP ATI A A +L G + AI+ ++ TPD Sbjct: 285 SADAIADKGLVNPFATIRAAAAILERHAGGKGIQ-----KLTEQAIQSLLQRKLTTPDQG 339 Query: 344 GNATTPQVADAICKIIL 360 G+ T + D + I Sbjct: 340 GSLKTEETVDHFLQAIA 356 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 111/293 (37%), Gaps = 19/293 (6%) Query: 69 FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDID 128 F+++ + LK + D YV + +R FPG C + D+D Sbjct: 110 FNSVLRNHAAVHVDILCDKEAKKKSLKICNDLDLYVFMTRLRSFPGFKC-----RFPDVD 164 Query: 129 FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTS 188 V+ +N G YS L +G VV V T V + LR+AFE A R +T Sbjct: 165 IQVIAQNNIGNYSELEYAPVKG----VVEALRVVTHENVTKYLRHAFEAAIRAGRCRVTL 220 Query: 189 ATKSNGLAISMPYWDERVEAM-AENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFG 247 K+N ++ E E M AE+Y I+ + +D R + P FD + ++ + Sbjct: 221 IHKANEWPVTDGAMVEIAEKMHAEDYCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYA 280 Query: 248 DILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMM 307 L+ + G + + L ++F+P+ + + ++ +P + + Sbjct: 281 TFLATICSGVAGGANLFSAIELGDSH---AVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDL 336 Query: 308 LDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 L+ +G + + + G KT + G T V I + Sbjct: 337 LNHVGQES-----CAKSLWKGMLRTMTDGIKTVEFDGPDTGEYVICNIMNKLR 384 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 188 bits (477), Expect = 4e-46, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 126/377 (33%), Gaps = 44/377 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M +RI G G G E+ V++ A R+ + F + + Y + + D+ Sbjct: 4 MDPLRIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRIYHSY---NSLPLADE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + + G + FR + V L Sbjct: 61 SQNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAIS-------AQSLYAVRQQLEA 113 Query: 122 KQPGDID-----FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 + D V+R+ +G Y+ ++ + V + F + I+ ++ E Sbjct: 114 VKVECFDRGTSSLLVIRDQAQGFYTGTNK---LESDQDSVSRVCHFRKGVFQHIIAFSLE 170 Query: 177 LAQSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ + K++ K + + + I+ + D + Sbjct: 171 RAREKWGYDLGGIKSVFLVYKFHLF---DGLLLSWARDWTKEF-GIKVEFIQPDTMNRNL 226 Query: 231 VMQPERFDVVVASNLFGDILSDLG----PACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 + +++A N + DI+ + + + L P S ++ HGSA Sbjct: 227 IAFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSEYQTTHGSA 286 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI----AHGPKTPDM 342 DI GK I NP ATI A A +L+ G I A +++ + + TPD Sbjct: 287 DDITGKGIVNPSATIRAAAAILERFGGCVG--------IDAKVDDTLNILQKNKSGTPDQ 338 Query: 343 KGNATTPQVADAICKII 359 GN TT D + + Sbjct: 339 GGNLTTAAFVDVFLRTL 355 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 71/425 (16%), Positives = 118/425 (27%), Gaps = 72/425 (16%) Query: 2 MKTMRIAAIPGDGI-GKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 +I A P I G+E+ ++L F +S + SC+ Sbjct: 74 SDKPKIKAPPMVYIQGEEMTHYATQLLLNQWIEPYFDISSWETFDLSCKARDDSDDATLI 133 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHIS-----LWGSLLKFRREFDQYVNLRPVRLFPGV 115 D E R AI+ P + RR ++ R G+ Sbjct: 134 DAVEAGKRIGAIFKEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGI 193 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT----------EHEVVIQESVFTRR 165 + R GEY + V EGT V+ + T + Sbjct: 194 ELGYKNQ------VLFERHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDK 247 Query: 166 ------------GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY 213 V + F+ TK +W + Y Sbjct: 248 HNVCVVYHNPYDNVRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFWATMKRVFDDTY 306 Query: 214 PEI------------RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTI 261 + D + + + + A N GD+L+D + Sbjct: 307 KDEFLKAGLLDRSGGELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSP 366 Query: 262 GIAPSANLNPERTFPSL---FEPVHGSAPD-----IYGKNIA-NPIATIWA--GAMM--- 307 G S + +L FE HG+ D + GK + NP+ + A GAM Sbjct: 367 GFITSNLVGVSDDGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAA 426 Query: 308 -LDFLGNGDERFQQ--------AHNGILAAIEEVIAHGPKTPDMKGNA--TTPQVADAIC 356 L++ ++ + N + A+ +G T DM G TT + Sbjct: 427 QLEYDAKPNDVEAKRMYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTGFTTEDFIAKVA 486 Query: 357 KIILR 361 + R Sbjct: 487 WRLDR 491 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 184 bits (468), Expect = 4e-45, Method: Composition-based stats. Identities = 66/410 (16%), Positives = 115/410 (28%), Gaps = 63/410 (15%) Query: 6 RIAAIPGDGI-GKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +I A P + G+E+ + +++A + + + + D E Sbjct: 7 KITAAPMVYVRGEEMTAYVMDLIRAKWIEPRVDTTAWREFDLRAKNRDDTEDQVLRDVIE 66 Query: 65 QLSRFDAIYFGAVGWPDTVPD-----HISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 AI+ P S RR ++ R GV Sbjct: 67 AGKAVKAIFKEPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGY 126 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------EHEVVIQESVFTRRG 166 + R GEY++ V +GT V + T Sbjct: 127 KKPVFFE------RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNE 180 Query: 167 ------------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP 214 V + R+ F TK P+W + E Y Sbjct: 181 AAVVTYHNPYDNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFWQIMKKVFDEEYK 239 Query: 215 -----------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 D + V + + A N GD+L+D + G Sbjct: 240 SKFVDAGVMKSGDELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGF 299 Query: 264 APSANLNPERTFPSL--FEPVHGSAPD-----IYGKNIA-NPIATIWAGAMMLDFLGNGD 315 S + + + FE HG+ D + G+ + NP+ + ++ + Sbjct: 300 ITSNLVGVDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVH 359 Query: 316 ----ERFQQAHNGILAAIEEVIAHGPKTPDMKGN--ATTPQVADAICKII 359 ER + A I ++ G T D+ G TT Q DA+ + + Sbjct: 360 NVDKERTLAFTAKMRAVIHQLFREGKGTRDLSGPSGLTTEQFVDAVAERL 409 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 180 bits (456), Expect = 1e-43, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 108/286 (37%), Gaps = 26/286 (9%) Query: 81 DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEY 140 D P LLK R+E Y ++RP L Q + + + Sbjct: 35 DGAPATSRPERGLLKLRKEMGTYGSMRPCFFASD---SLVAPQGRGVPRHRLCHCARAHR 91 Query: 141 SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 L R G+ ++ V+R A L + R K L S +N LA S Sbjct: 92 RYLLWRAQTGSG--SAWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSRF 149 Query: 201 YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVASNLFGDILSDLGPACTG 259 + E + +P+++ + Q I+ V P + VVV S LFGDI+SD Sbjct: 150 WRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPD 209 Query: 260 TIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 +IG+ PSA+L + R ++EP+H + + A+ + + Sbjct: 210 SIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC----------- 256 Query: 316 ERFQQAHNGILAAIEE--VIAHGPKTPDMKGNATTPQVADAICKII 359 + + + ++ V +T ++ G A T ++ +A+ + Sbjct: 257 -PWPCFSDTLSTSLRRLWVPPWSLRTKELGGGANTKELGEAVINEV 301 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 173 bits (439), Expect = 7e-42, Method: Composition-based stats. Identities = 64/435 (14%), Positives = 115/435 (26%), Gaps = 108/435 (24%) Query: 8 AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLS 67 + D G E+ R+++ L + + + E Sbjct: 66 PIVEMD--GDEMARIMWRMIKDKLIFPYLDLDIRYFDL-GILNRDATDDKVTVESAEATL 122 Query: 68 RFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 +++ A PD R + V P+ L VP + G Sbjct: 123 KYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPI-LCXNVPRIVPGW 181 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV---------------------IQESV 161 + + R +Y + V + ++V I ++ Sbjct: 182 KKP---ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKGPGIALAM 238 Query: 162 FTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDK 220 + R + LA + + L +TK+ L R++ Sbjct: 239 YNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG----------------RYEH 281 Query: 221 QHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA------------------------ 256 + ID + A + + V N GD+ SDL Sbjct: 282 RLIDDMVAYALKSDGGY-VWACKNYDGDVQSDLLAQGFLLHMRNERSDYPVXLHLVKSYP 340 Query: 257 ---------CTGTIGI---APSANLNPERTFPSLFEPVHGSAPDI---YGKNI---ANPI 298 G+ L+ + E HG+ Y K + N I Sbjct: 341 ILFVLSRIRFFGSYDFSIAISGKQLSSDGKTL-EAEAAHGTVTRHFRQYQKGLETSTNSI 399 Query: 299 ATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMK----GN------- 345 A+I+A L+ D ER + + AA E + G T D+ G Sbjct: 400 ASIFAWTRGLEHRAKLDKNERLLDFVHKLEAACIETVESGNMTKDLAILIHGPKASXEFY 459 Query: 346 ATTPQVADAICKIIL 360 T + D + + Sbjct: 460 LNTEEFIDTVAHNLE 474 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 165 bits (419), Expect = 2e-39, Method: Composition-based stats. Identities = 48/132 (36%), Positives = 67/132 (50%), Gaps = 8/132 (6%) Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P +FDV+V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGA--NGVAIFESVHGTAPDI 87 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATT 348 GK++ANP A + + MML +G I A + I T D+ GN Sbjct: 88 AGKDMANPTALLLSAVMMLRHMG-----LHGHAKKIETACFDTIRDKKVLTKDLGGNPKC 142 Query: 349 PQVADAICKIIL 360 + IC+ + Sbjct: 143 SEFTADICRRVQ 154 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 157 bits (397), Expect = 6e-37, Method: Composition-based stats. Identities = 46/206 (22%), Positives = 81/206 (39%), Gaps = 29/206 (14%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYS-HHGKM 57 I I GDGIG ++ P I+V+ AA ++ +S+ ++ Sbjct: 26 PNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTW 85 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P + + + + G + P + + R++ D YV LRPVR F GVP Sbjct: 86 LPQETLDAVKDYVVSIKGPLTTP----VGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPS 141 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVVIQ 158 P+ +PGD+D + REN+E Y+ + + + + I Sbjct: 142 PVK--KPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIG 199 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRK 184 ++ G R+ R A A++ K Sbjct: 200 VKPVSKEGTKRLARKALHSAEAAVVK 225 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 154 bits (390), Expect = 4e-36, Method: Composition-based stats. Identities = 65/378 (17%), Positives = 126/378 (33%), Gaps = 53/378 (14%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE--RWGFALSFEQMEWASCEYYSHHGKMMP 59 + I I GDG G E+ I + +A E G + + E Y +GK +P Sbjct: 13 PDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGKYLP 72 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 + E + + + G + +I+ + +R + Y +++ + PG+ Sbjct: 73 RESIEDIRKTVFVMKGPLSS------NINGHDININIKRILNLYTDVKCITGLPGLSEGK 126 Query: 117 -----CPLAGKQP------GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR 165 P + D D +Y ++ G + ++ +R Sbjct: 127 EIFIFSPSIDEVYHFSYDSEDSDMLR-------QYLQQSFNISIGGDSDIF--LKGTSRY 177 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDI 225 + +I E++ K A G P W + + + + + Sbjct: 178 RIIKIASKIAEISSLYGIKRTLVADDYTGSHA--PLW--VYNTLNKMEMPVEIENLY--- 230 Query: 226 LCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGS 285 + RF++ + + ++ + A T A L F SLFE Sbjct: 231 NLYDEMTSESRFNIFIPDSRLSSLIIKIINART-----FFGAILGD---FISLFESQSRP 282 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP--DMK 343 + G ++A+P + + A +MML L F A + A+ V + G ++ Sbjct: 283 SFTEEGYDLADPTSFLLASSMMLRRL-----NFNDAALILRNALNSVYSDGILPASLNLN 337 Query: 344 GNATTPQVADAICKIILR 361 DAI K + R Sbjct: 338 NGLKCSDFIDAIVKRMKR 355 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 148 bits (374), Expect = 3e-34, Method: Composition-based stats. Identities = 47/186 (25%), Positives = 77/186 (41%), Gaps = 16/186 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG E+ +++ AA + FE E A + Y G+++P+ +E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFET-ENAGSDVYEKTGELIPESLYES 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R G + P + R+++D Y N R R PG+ + Sbjct: 58 VERNKIAIKGPITTPI----GKGFRSINVYLRKKYDLYTNFRSSRNLPGIET-----RYD 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +ID + RENTEG Y NE I T++G + +L+ + + + Sbjct: 109 NIDLAIFRENTEGIYIGEEKYENEEKT--SAIAVKRITKKGSEELLKVLLNMQRIMEFRK 166 Query: 186 LTSATK 191 L K Sbjct: 167 LQLFIK 172 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 143 bits (362), Expect = 7e-33, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 63/174 (36%), Gaps = 18/174 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + PG G+G E+ + AA + +++ + ++ D Sbjct: 31 QFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHID-VDNAKPGQDLISADAL 85 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P L R+ Y N+RP PGV P Sbjct: 86 DSLRRNRFGLKGPMATPI----GKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---- 137 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 D+D VRENTEGEYS L V G VV V T V+ ++ F + Sbjct: 138 -DDVDVVTVRENTEGEYSGLEHVVYPG----VVESLKVITPERVNARVQVPFSI 186 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 137 bits (346), Expect = 5e-31, Method: Composition-based stats. Identities = 74/375 (19%), Positives = 127/375 (33%), Gaps = 46/375 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY-------SHHGKM 57 + G G G+EV RVL A R ++ + Y G Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAG 90 Query: 58 MPD---DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 +P+ E + ++ V ++ L R+ LR V+ Sbjct: 91 VPEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQ-----RLRAVK---- 141 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + +VR+ +G Y+ V + + F+R +++L YA Sbjct: 142 ----VDTLDADGARLLLVRDEAQGFYTG-----GNTHTPGHVSRTTEFSREITEQLLAYA 192 Query: 175 FELAQSR---PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 A+ + A K + L D V A I D + V Sbjct: 193 LRRAREEWPEGPARIVMAYKFHLL---DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLV 248 Query: 232 MQP-ERFDVVVASNLFGDILSDLGPACTGTI----GIAPSANLNPERTFPSLFEPVHGSA 286 P E V++A N + DI+ + G+ + +L+P ++ VHGSA Sbjct: 249 AHPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAVAELVEYQTVHGSA 308 Query: 287 PDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN 345 D+ G+++ NP+AT+ A A + ++G A V +TPD G Sbjct: 309 DDLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGV-----RTPDQGGK 363 Query: 346 ATTPQVADAICKIIL 360 +T V DA + + Sbjct: 364 HSTTGVVDAFIEELG 378 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 129 bits (325), Expect = 1e-28, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 103/263 (39%), Gaps = 10/263 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++A + GD V+ + +++++ A ++ + + +P+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDS-TAFEVTELPF-GVNGVLSFNEPLPNQTLR 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLAGK 122 +L +D I GA+ +S+ SL+ R+ + + + V++ PL + Sbjct: 60 ELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLKNQ 119 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 D DF +V+ + + + + +R V++++ FE A +R Sbjct: 120 IVRDTDFIIVQSAK----RANDHVDGNISVDDFAQDTITYEQREVEQVITAGFERAMNRK 175 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T T + + W E +A+ YP++ + + + + + QP DVVVA Sbjct: 176 RA-VTVVTPFDSF-YTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDVVVA 233 Query: 243 SNLFGDILSDLGPACTGTIGIAP 265 +L++ TG P Sbjct: 234 PKWVDQVLNEESQKITGLPETVP 256 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 46/226 (20%), Positives = 89/226 (39%), Gaps = 18/226 (7%) Query: 138 GEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 G ++ L EG VV SV +++G D+ LRYAF+ A RK +T K+ I Sbjct: 2 GIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPI 57 Query: 198 SMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 S E + + +Y + + + ++ +R + +P FD + AS + LS + Sbjct: 58 SDGSLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSG 117 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN--PIATIWAGAMMLDFLGNG 314 G + + + ++F+P+ + N AN + + LG+ Sbjct: 118 VCGGANLFSAVEIGDHH---AVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGH- 170 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + + ++ + G +T + G T V I + Sbjct: 171 ----DKCADALWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLR 212 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 121 bits (305), Expect = 3e-26, Method: Composition-based stats. Identities = 66/125 (52%), Positives = 80/125 (64%), Gaps = 12/125 (9%) Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT- 300 N+FGDILSDLGPACTGTI +APS ++NPE FPSLFEPVHGS PDI+GK IANPI Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 301 --IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG----PKTPDMKGNATTPQVADA 354 GAM+LD LG + I + IE+V++ G P TPD+ G+A T + A Sbjct: 61 ARFGVGAMILDHLGY-----PETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKA 115 Query: 355 ICKII 359 I I Sbjct: 116 IAAAI 120 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 52/227 (22%), Positives = 87/227 (38%), Gaps = 26/227 (11%) Query: 157 IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPY---WDERVEAMAENY 213 I + + F A S K + K + + ++ +A ++ Sbjct: 355 ILLMSNDHEAIKDWVSQVFRDASS-KHKEVYFGLKREYMEYDEVFSTVINDVRRELAADH 413 Query: 214 -PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 + + + P R + A NL GDI SD+ A G++ A S + Sbjct: 414 TSPPAFMIMRPSSQLIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASS--IIES 471 Query: 273 RTFPSLFEPVHGSAPDIYGKNIA--------NPIATIWAGAMMLDFLG--NGDERFQQAH 322 ++ LFE HG+A D+Y K + NP A I+A A L+ LG +E Sbjct: 472 KSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYS 531 Query: 323 NGILAAIEEVIAHGPKTPDMKGNATTPQ---------VADAICKIIL 360 + AA+++ + G T D+K TTP+ D+I K + Sbjct: 532 ARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRLG 578 Score = 80.4 bits (197), Expect = 9e-14, Method: Composition-based stats. Identities = 38/295 (12%), Positives = 80/295 (27%), Gaps = 56/295 (18%) Query: 1 MMKTMRI----AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK 56 M+ +++ + GD E+ + A+ +++ ++ + +G+ Sbjct: 1 MVNKIQVESPLVILHGD----EMAQVAFEEILKKFVTTRLAIELIEIDLSAEHRFLTNGQ 56 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVP----------------DHISLWGSLLKFRREF 100 ++ + E L ++ A + D ++ R+ Sbjct: 57 VIF-EAIEALKKYGVGVKNAGMTVNREQLDAMLEKHPELSQSRLDPLATKSPNGAIRKGI 115 Query: 101 DQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE--GEY--------------SSLG 144 + ++ F + DID + +N Y Sbjct: 116 GGNITREDIQ-FQNLRVRKPDWIDRDIDVDTM-DNGGIKDSYNELSSSTGVVKLLFVGKS 173 Query: 145 GRVNEGTEHEVV----IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 G E +V + V F+ A R K +A Sbjct: 174 GNPVELHRRDVKKGDPWLLATNDIADVKAWAHRFFQRAIDEKRDA-YLGLKDTVIAGYDG 232 Query: 201 YWDERVEAMAE-NYP------EIRWDKQHIDILCARFVMQPERFDVV-VASNLFG 247 +EA+ + Y I + + +D AR V P + V N G Sbjct: 233 VMRAAIEAIYKQEYKKQFEAVGINYYYELVDAQAARIVANPPERALWGVPDNTTG 287 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 90/243 (37%), Gaps = 27/243 (11%) Query: 142 SLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKS---NGLAIS 198 ++ I R + ++ F A +K + K N + Sbjct: 341 GEEKHARTVKSNDP-ILFMSNDRESIKDWVKQVFRDAALY-KKEVYFGLKREFVNYDEVY 398 Query: 199 MPYWDERVEAMAE-NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 E + +A + P + ++ + P R+ + A NL GDI SD+ A Sbjct: 399 SSIILEIRKELAALDTPPPSFMIMRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAAL 458 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA--------NPIATIWAGAMMLD 309 G++ A S + + T LFE HG+A D+Y + + N A I+A A L+ Sbjct: 459 GGSLATASSVIKSKDGTL--LFEAPHGTAHDLYLRYLETDGKEANFNSSALIFAVANALE 516 Query: 310 FLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ---------VADAICKI 358 L + + + AA+ E +A G T D+KG P+ DAI Sbjct: 517 ELARREDNAPLAEYAEALKAALIETVAQGTITGDLKGKTLAPESETVVDMYGFLDAIESN 576 Query: 359 ILR 361 + + Sbjct: 577 LNK 579 Score = 78.8 bits (193), Expect = 3e-13, Method: Composition-based stats. Identities = 34/296 (11%), Positives = 83/296 (28%), Gaps = 58/296 (19%) Query: 1 MMKTMRI----AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK 56 M + +++ + GD E+ + + +++ ++ + + +G+ Sbjct: 1 MGERIKVEKPLVILHGD----EMAQIAFERILEQFVTSRLDIQLVEVDLSAEQRLTSNGQ 56 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVP----------------DHISLWGSLLKFRREF 100 ++ + E L A + D ++ R+ Sbjct: 57 VVL-EAIEALKDHGIGVKNAGMTVNRSQLDEMLAKYPQINEAQLDKLATKSPNGAIRKGI 115 Query: 101 DQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE---YS------SLGGRVNEGT 151 + + F + DI+ + + G YS + + G+ Sbjct: 116 GGNITREDI-EFRNLTSVRPDWVNRDIEVDTM--ESGGLDFSYSELSDATGVAKVMFVGS 172 Query: 152 EHEVV------------IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 + V + V F+ A R + K + Sbjct: 173 SGDPVELHRRTLKKGDPWMLATNDLDDVKAWAHRFFQRALDEKRD-IYLGLKDTVVPGYD 231 Query: 200 PYWDERVEAMA-ENYPE------IRWDKQHIDILCARFVMQPERFDVV-VASNLFG 247 +E + +Y + +++ + ID AR V P + + V N+ G Sbjct: 232 GVMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNPPQRALWGVPDNVSG 287 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 113 bits (282), Expect = 1e-23, Method: Composition-based stats. Identities = 33/114 (28%), Positives = 48/114 (42%), Gaps = 3/114 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 98 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + DA+ GA+G H+ LL+ R + NLRP + P Sbjct: 99 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 107 bits (267), Expect = 7e-22, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 60/164 (36%), Gaps = 14/164 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAA-ERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + ++ + GD IG E++ E ++ L ER F + A + + Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAGAS-LDKTNEPIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-- 115 D + DA+ G+VG P+ P ++ +L+ R+ D + N+RP R Sbjct: 60 DKVLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRFCASSLV 119 Query: 116 -PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 PL + N +Y++ ++ + Sbjct: 120 EQSPLKSDMVNGV-------NFGEQYAARSRSTGGCCTKDIGLA 156 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 107 bits (267), Expect = 8e-22, Method: Composition-based stats. Identities = 30/111 (27%), Positives = 45/111 (40%), Gaps = 9/111 (8%) Query: 96 FRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV 155 D Y ++ ++ P V D+D VV ENTEGEYS+L +G Sbjct: 2 LHTTLDLYASVIHLKNLPNVET-----WHKDVDILVVWENTEGEYSNLEHESVKGVTE-- 54 Query: 156 VIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 + T+ RI YAF+LAQ K + + K N + + + Sbjct: 55 --SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 105 bits (261), Expect = 4e-21, Method: Composition-based stats. Identities = 31/201 (15%), Positives = 60/201 (29%), Gaps = 34/201 (16%) Query: 86 HISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGG 145 R + V P+ L VP L+G + + R +Y + Sbjct: 28 KSMWRSPNGTIRNILNGTVFREPI-LCKNVPRILSGWKKP---ICIGRHAFGDQYRATDT 83 Query: 146 RVNEGTEHEVV--------------------IQESVFTRRGVDR-ILRYAFELAQSRPRK 184 +N + ++V + S++ R + +A S + Sbjct: 84 IINGPGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKW 142 Query: 185 TLTSATKSNGLAISMPYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERF 237 L +TK+ L + + + + I ++ + ID + A V + Sbjct: 143 PLYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGY 202 Query: 238 DVVVASNLFGDILSDLGPACT 258 V N GD+ SD Sbjct: 203 -VWACKNYDGDVQSDFLAQIF 222 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 98.8 bits (245), Expect = 2e-19, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 46/134 (34%), Gaps = 15/134 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+L + + + + FE + S + Sbjct: 50 RHTVTLIPGDGIGPELLNHVRELFRFSC----VPVDFEVVHVNSSSTSEDDIS----NAI 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + T+P + R D Y N+ + PGV + Sbjct: 102 MAIRRNGVALKGNIETNHTMPP--NHKSRNNLLRTSLDLYANVMHCQSLPGVQT-----R 154 Query: 124 PGDIDFYVVRENTE 137 +ID ++ E +E Sbjct: 155 HKNIDIIIILEKSE 168 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 95.8 bits (237), Expect = 2e-18, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 7/113 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I I GDGIG E++ E +VL ++G + +E + C G + D+ Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCS-IDATGVPLTDEAIAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDH------ISLWGSLLKFRREFDQYVNLRPVRLF 112 DA+ G++G + LLK R+ + + NLRP L+ Sbjct: 63 AKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 90.4 bits (223), Expect = 8e-17, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 110/356 (30%), Gaps = 80/356 (22%) Query: 2 MKTMRIAAIPGD--GIGKEVLPEGI---RVLQAA--------------AERWGFALSFEQ 42 M +IA IPGD GIG E++ + + V +AA A + G L + Sbjct: 6 MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65 Query: 43 MEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQ 102 + WA+ + + E + D S +L + D Sbjct: 66 IAWANLAEF----SGLRQLEMETIDVADV--------KVAEVTIQSGKSALRTLDQALDL 113 Query: 103 YV--NLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE------YSSLGGRVNEGTEHE 154 V + V P L N E E Y G +E + Sbjct: 114 AVAGIVDGVLFGPFNKAALTAAGL----------NAEDEHRYMARYLGFKGYHSEVNVLD 163 Query: 155 VVIQESV------------FTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPY 201 ++ V T GV + + A + + A + N A Sbjct: 164 DLMTTRVTSHIGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGK 223 Query: 202 W-DERVEAMAENYPEIRWDKQHID----ILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + E ++ +A E + H+ + D VV ++ D + Sbjct: 224 FGREEIDILAPVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIK 280 Query: 257 CTG---TIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLD 309 G + +A + + P HG+A DI G+++AN AT A ++L Sbjct: 281 LMGFDRGVTVAGGLPI-------PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLR 329 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 85.4 bits (210), Expect = 3e-15, Method: Composition-based stats. Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TP 340 VHGSAP G NP A + +G MML +L +A I +++V+A T Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNE-----HEAATRIEKGVDKVLAEAKHLTY 58 Query: 341 DMKGNATTPQVADAICKIIL 360 D G A+T + ADAI K + Sbjct: 59 DAGGTASTDEYADAIIKAMG 78 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 85.4 bits (210), Expect = 3e-15, Method: Composition-based stats. Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%) Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK 338 +EP GSAPDI GKNIANPIA I + AM++ + + + I +A+ + + G + Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRY----TMKLPIISDQIESAVIDTLKKGYR 66 Query: 339 TPDMKGNA----TTPQVADAICKIILR 361 T D+ + +T + D I I+ + Sbjct: 67 TLDIANDKEKCESTNDIGDIISYILKK 93 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 84.6 bits (208), Expect = 5e-15, Method: Composition-based stats. Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 5/105 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T I + GDGIG E+ E ++VL +A C G + Sbjct: 360 MTTHTILVLRGDGIGLEITAEAVKVL-SAFSLKKRTFDLRSELIDGCS-IDTDGTPITKT 417 Query: 62 WHEQLSRFDAIYFGAVGWPDTVP---DHISLWGSLLKFRREFDQY 103 + DA+ F +VG P D G LL+ R+ +Q+ Sbjct: 418 VIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 81.5 bits (200), Expect = 4e-14, Method: Composition-based stats. Identities = 44/82 (53%), Positives = 57/82 (69%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + RIA IPGDGIGKE +PE +RV AAA R+GFAL ++AS + + HGK+ PDD Sbjct: 1 MSSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDD 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTV 83 + L +DA++FGAVG PDT Sbjct: 61 RFDTLRGYDALFFGAVGRPDTG 82 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 79.2 bits (194), Expect = 2e-13, Method: Composition-based stats. Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDG+G EV+P + VL A G SFE++ G +P + Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGV-ALDLVGVPLPKET 97 Query: 63 HEQLSRFDAIYFGAVGWP 80 + + DA+ GAVGW Sbjct: 98 LIRAKQSDALLLGAVGWY 115 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 76.9 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 32/129 (24%), Positives = 50/129 (38%), Gaps = 9/129 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + F ++ LK + D YV R FPG C Sbjct: 99 EAGQDDEYFHSVLRNRTAVHVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKC--- 155 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D ++ +N G ++ L EG VV SV +++G D+ LRYAF+ A Sbjct: 156 --RFPGVDIQLIGQNNMGIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAK 209 Query: 181 RPRKTLTSA 189 RK +T Sbjct: 210 AGRKRVTLI 218 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 76.9 bits (188), Expect = 1e-12, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 8/82 (9%) Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 GSAPDI GKNIANPIA I + AM++ + + + + I +++ + + G KT D+ Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRY----TMKLHKIADDIESSVIDALKKGYKTLDIA 57 Query: 344 G----NATTPQVADAICKIILR 361 + +T + D I I+ + Sbjct: 58 NVNETHISTSDMGDVISNILNK 79 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 75.7 bits (185), Expect = 2e-12, Method: Composition-based stats. Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 6/67 (8%) Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 IANP A + + ML + Q I AI EV+A G +T D+ G+++T + Sbjct: 155 IANPTAMLMCASKMLRHV-----NLQHYSESIRNAIREVLAAGKVRTRDLGGSSSTHEFT 209 Query: 353 DAICKII 359 DA+ K I Sbjct: 210 DAVIKAI 216 Score = 70.3 bits (171), Expect = 1e-10, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 42/103 (40%), Gaps = 8/103 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + IPGDG+ E++ VL+A G + FE + ++ ++ +D Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAI----GAPIDFETILFSEVQH---SSSAKVEDV 115 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVN 105 + ++R GA+ PD L +K R+ D N Sbjct: 116 IKSINRNRICLMGALMSPDVSYSGE-LQNLHMKLRKGLDLIAN 157 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 75.3 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 2/79 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 KT +IA+IPGD IG EV+ I VL++ E + L F +++W Y GK MP D Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDW-GTARYKRTGKYMPAD 65 Query: 62 WHEQLSRFDAIYFGAVGWP 80 L F A FGAVG P Sbjct: 66 GLSTLKTFHAGIFGAVGAP 84 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 69.6 bits (169), Expect = 1e-10, Method: Composition-based stats. Identities = 27/79 (34%), Positives = 35/79 (44%), Gaps = 3/79 (3%) Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP 340 P+HG APDI G IANP A + A +L G + Q N I +A E TP Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGYEELAQQVE-NQIESAFYE--NRDQTTP 265 Query: 341 DMKGNATTPQVADAICKII 359 D G T + + + I Sbjct: 266 DQGGVLNTEKYMAMMVECI 284 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 68.4 bits (166), Expect = 4e-10, Method: Composition-based stats. Identities = 12/113 (10%), Positives = 25/113 (22%), Gaps = 10/113 (8%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++ + D G E+ ++ + + + Y + Sbjct: 42 KRIKVSQPVVEMD--GDEMTRIIWEFIKEKLILSNVDVELKYYDL-GLPYRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRP 108 D ++ A PD R V P Sbjct: 99 DSAIATQKYHVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTVFREP 151 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 67.6 bits (164), Expect = 7e-10, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 26/76 (34%), Gaps = 7/76 (9%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + IPGDGIG E+ + + + +EQ + G+ + E Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYV----NAPIEWEQYNVSGMSSA---GEDLFKQAVE 61 Query: 65 QLSRFDAIYFGAVGWP 80 L R G + P Sbjct: 62 SLRRNRVGLKGILFTP 77 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 67.3 bits (163), Expect = 7e-10, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 31/77 (40%), Gaps = 5/77 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ IPGDGIG E+ ++ +AA + ++ ++ + + +P E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA----NAPIEWDPVDVTPVKGDDGIFR-IPSKCIEL 81 Query: 66 LSRFDAIYFGAVGWPDT 82 + G + P+ Sbjct: 82 MRINKIGLKGPLATPNW 98 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 67.3 bits (163), Expect = 9e-10, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 28/75 (37%), Gaps = 11/75 (14%) Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NA 346 NIANP + A ML ++G I A + + G T D+ Sbjct: 6 NIANPSGLLNAAVHMLIYIGQVGT-----AKLIYDAWLKTLEGGIHTADLYKEKRSKQKV 60 Query: 347 TTPQVADAICKIILR 361 T + A+A+ + + Sbjct: 61 GTKEFAEAVIDNLGK 75 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 65.7 bits (159), Expect = 2e-09, Method: Composition-based stats. Identities = 27/59 (45%), Positives = 33/59 (55%), Gaps = 1/59 (1%) Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAH 335 +FEP HGSAPDI G+NIANPIA IW+GA ML G + A + V+ Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHRHPSAAGHGANKAVMID 59 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 63.0 bits (152), Expect = 1e-08, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 30/101 (29%), Gaps = 3/101 (2%) Query: 149 EGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 + + V +R A + + L A K N + + + Sbjct: 139 REIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAAE 198 Query: 209 MAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 E+ I W ID + A V P + ++ + F Sbjct: 199 TLESLAGAAGIAWRSLIIDHMAAELVRNPLDYRAILTHSSF 239 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 61.5 bits (148), Expect = 5e-08, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 3/55 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG 55 M K I +PGDGIG E++ E ++VL+ A E++ + HG Sbjct: 8 MSKQ--ILILPGDGIGPEIMTEAVKVLELANEKYQLGFEL-THDVIGGAAIDKHG 59 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.1 bits (147), Expect = 6e-08, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 37/107 (34%), Gaps = 31/107 (28%) Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 +GP +G+ L E ++Y KNIANP AT+ A MMLD L Sbjct: 25 VGPELMAAVGVIECLKLGDGLFLQCCEE-----VAELYPKNIANPTATLLASCMMLDHL- 78 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 KT DM G AT +A+ + Sbjct: 79 -------------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 61.1 bits (147), Expect = 7e-08, Method: Composition-based stats. Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 10/93 (10%) Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 L G QP ++ +V EN EGEYS GR + E++I + + A+ Sbjct: 80 RSSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG---------LSKIAY 130 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 +L + P K + ATKSN + W+E Sbjct: 131 QLLRG-PEKHIAIATKSNAQRNGLVIWNEVAAE 162 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 56.1 bits (134), Expect = 2e-06, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 6/62 (9%) Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + A +MLD L + N I +AI + T D+ G TT +V +I +I Sbjct: 1 MLLASCLMLDHL-----KLHDYANMIRSAILTTMNETRLHTVDIGGQGTTSEVVQSIMRI 55 Query: 359 IL 360 I Sbjct: 56 IQ 57 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 54.9 bits (131), Expect = 5e-06, Method: Composition-based stats. Identities = 14/71 (19%), Positives = 24/71 (33%), Gaps = 4/71 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPGDGIG E+ +++ AA + S E Y + + Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQANVRPCVSIEGYKFNEMYLDTVCLNI 61 Query: 66 LSRFDAIYFGA 76 + A + Sbjct: 62 ETACFATIKCS 72 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 53.4 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 23/71 (32%), Gaps = 8/71 (11%) Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-------NYPE 215 T + + A + L +TK+ L + + + + E Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 216 IRWDKQHIDIL 226 I ++ + ID + Sbjct: 60 IWYEHRLIDDM 70 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 53.4 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 16/44 (36%), Positives = 27/44 (61%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCE 49 +I A+ GDGIG E++ G+ VL+A AE+ GF ++ + + Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGAD 47 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 51.9 bits (123), Expect = 4e-05, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 25/79 (31%), Gaps = 14/79 (17%) Query: 296 NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKG--------- 344 NPIA+I+A L D + N + E I G T D+ Sbjct: 6 NPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSAQ 65 Query: 345 ---NATTPQVADAICKIIL 360 T + + + + + Sbjct: 66 CSDYLNTFEFMEKLGENLK 84 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 51.1 bits (121), Expect = 6e-05, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 19/37 (51%) Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 R + +T K+N + ++ + +A+++P++ Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_D2H627 Putative uncharacterized protein n=1 Tax=Ailuropoda melanoleuca RepID=D2H627_AILME Length = 185 Score = 48.0 bits (113), Expect = 5e-04, Method: Composition-based stats. Identities = 10/80 (12%), Positives = 19/80 (23%), Gaps = 7/80 (8%) Query: 48 CEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQ 102 E + + D E + +++A A PD R Sbjct: 106 IENHDATNDQVTKDAAEAIKKYNAGVKCAAITPDEKRVEEFKLKQMWKSPNGTIRNILGG 165 Query: 103 YVNLRP--VRLFPGVPCPLA 120 V + P + + Sbjct: 166 TVFREAIICKNIPRLASDVR 185 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 46.8 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 14/28 (50%), Positives = 21/28 (75%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAER 33 +I A+ GDGIG E++ G+ VL+A AE+ Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEK 31 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 46.1 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 30/83 (36%), Gaps = 14/83 (16%) Query: 292 KNIANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDM----KGN 345 K NPIA+I+A + L+ D R + + A E + G + D+ G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 346 --------ATTPQVADAICKIIL 360 T+ + D + + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERLK 85 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 45.7 bits (107), Expect = 0.003, Method: Composition-based stats. Identities = 27/174 (15%), Positives = 48/174 (27%), Gaps = 18/174 (10%) Query: 188 SATKSNGLAISMPYWDERVEAMAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASN 244 K N + + + + E I + ID + A P+ + ++ Sbjct: 1 MTHKGNSIKYTDGLFAVVAKQELEKLIGDSGIIQESLIIDHMAAELTRNPQDYRAILTHG 60 Query: 245 ---------LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 L G + +D TIG A + +L H AP+ Sbjct: 61 AFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYD---VALDPARHTRAPEAEAAGRL 116 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 + + AG+++ D L G T + A T Sbjct: 117 RSV--LLAGSLLADHLDQGVAAAGIRAAADALDAPATADGHAGTAGLAACARTA 168 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 45.3 bits (106), Expect = 0.003, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 18/45 (40%), Gaps = 4/45 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA 46 ++ PGDGIG E+ +V AA + +++ Sbjct: 41 STPIKATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVG 81 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 44.1 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 25/52 (48%), Gaps = 6/52 (11%) Query: 310 FLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G G++ N I A+E+V+ +T + G+ATT + A + + Sbjct: 39 HVGEGEK-----ANAIRNAVEKVLNIDNVRTGGLGGSATTKEFTAATERRLA 85 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 44.1 bits (103), Expect = 0.008, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 35/89 (39%), Gaps = 9/89 (10%) Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV 332 +LFEP+ S + K NPI I++ A++L G Q+ I A+ Sbjct: 2 GIGINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLSRFG-----LQEEAGAIQMAVNSA 54 Query: 333 IAHG-PKTPD-MKGNATTPQVADAICKII 359 G T D + + Q+ D + I Sbjct: 55 GERGMYTTLDTLPKDINCDQLGDYLAAAI 83 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 42.6 bits (99), Expect = 0.022, Method: Composition-based stats. Identities = 9/25 (36%), Positives = 13/25 (52%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQ 28 + IPGDGIG E++ V + Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFR 136 >UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis RepID=A7IS87_NEIME Length = 44 Score = 42.2 bits (98), Expect = 0.029, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 2/46 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS 47 M IA + GDGIG E++ E +RVL + G +E Sbjct: 1 MTKH-IAILRGDGIGSEIVAETVRVLDKLIAQ-GLDAGYEYAPLGG 44 >UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10 Tax=Proteobacteria RepID=PDXA2_PSEAE Length = 337 Score = 41.8 bits (97), Expect = 0.037, Method: Composition-based stats. Identities = 32/156 (20%), Positives = 51/156 (32%), Gaps = 21/156 (13%) Query: 166 GVDRILRYAFELA-QSRPRKTLTSATKSNGLAISMPYWDERVEAMA-----ENYPEIRWD 219 R++ A + +RPR + NG S E ++ +A I D Sbjct: 190 EAIRLIDDALRRSGLARPRIGVCGLNPHNGDNGSFG--REELDIIAPAVQKAREQGIAAD 247 Query: 220 -KQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTG-TIGIAPSANLNPERTFPS 277 D + + FD VV ++ D + G + G+ Sbjct: 248 GPYPADTIFLKVQGDARAFDAVVT--MYHD-QGQIAIKLMGFSRGVTVQG-----GLPIP 299 Query: 278 LFEPVHGSAPDIYGKNIANPIATIWA---GAMMLDF 310 + P HG+A DI G+ A+ AT A M Sbjct: 300 IATPAHGTAFDIAGQGRADVGATRQAFEIACRMGRH 335 >UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q0V0_9BACT Length = 346 Score = 41.5 bits (96), Expect = 0.053, Method: Composition-based stats. Identities = 15/30 (50%), Positives = 17/30 (56%), Gaps = 3/30 (10%) Query: 281 PVHGSAPDIYGKNIANPIAT---IWAGAMM 307 P HG+A DI GK IANP + I MM Sbjct: 310 PDHGTAYDIAGKGIANPDSMKEAIMTAIMM 339 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.311 0.147 0.408 Lambda K H 0.267 0.0454 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,137,283,000 Number of Sequences: 3077464 Number of extensions: 84784833 Number of successful extensions: 280759 Number of sequences better than 1.0e-01: 240 Number of HSP's better than 0.1 without gapping: 646 Number of HSP's successfully gapped in prelim test: 76 Number of HSP's that attempted gapping in prelim test: 276395 Number of HSP's gapped (non-prelim): 799 length of query: 361 length of database: 1,040,396,356 effective HSP length: 130 effective length of query: 231 effective length of database: 640,326,036 effective search space: 147915314316 effective search space used: 147915314316 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 94 (40.7 bits)