BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (361 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 581 e-164 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 544 e-153 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 459 e-128 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 378 e-103 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 369 e-101 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 349 1e-94 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 347 3e-94 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 345 1e-93 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 345 2e-93 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 340 3e-92 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 340 6e-92 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 338 2e-91 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 324 3e-87 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 307 5e-82 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 303 5e-81 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 296 9e-79 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 283 5e-75 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 277 4e-73 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 262 1e-68 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 257 5e-67 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 243 7e-63 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 232 1e-59 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 224 3e-57 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 222 2e-56 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 221 3e-56 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 214 3e-54 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 214 5e-54 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 214 5e-54 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 211 4e-53 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 209 9e-53 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 204 3e-51 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 204 4e-51 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 203 6e-51 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 202 1e-50 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 200 8e-50 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 199 1e-49 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 197 6e-49 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 195 2e-48 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 194 5e-48 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 192 1e-47 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 192 2e-47 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 192 2e-47 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 191 4e-47 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 190 6e-47 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 190 7e-47 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 190 7e-47 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 189 1e-46 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 189 2e-46 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 188 3e-46 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 187 5e-46 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 187 7e-46 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 185 2e-45 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 184 4e-45 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 182 2e-44 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 181 4e-44 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 180 6e-44 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 179 2e-43 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 179 2e-43 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 178 2e-43 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 178 3e-43 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 174 4e-42 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 172 2e-41 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 171 4e-41 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 170 6e-41 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 170 7e-41 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 170 9e-41 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 168 2e-40 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 168 3e-40 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 166 8e-40 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 166 1e-39 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 164 3e-39 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 164 3e-39 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 164 4e-39 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 164 6e-39 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 163 7e-39 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 163 9e-39 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 162 2e-38 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 162 2e-38 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 162 2e-38 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 162 3e-38 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 160 6e-38 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 160 7e-38 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 159 1e-37 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 159 2e-37 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 157 4e-37 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 157 6e-37 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 155 2e-36 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 155 2e-36 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 155 2e-36 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 155 3e-36 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 155 3e-36 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 154 4e-36 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 152 1e-35 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 152 2e-35 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 151 4e-35 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 150 7e-35 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 149 1e-34 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 149 2e-34 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 148 3e-34 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 148 3e-34 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 148 4e-34 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 147 5e-34 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 147 6e-34 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 147 8e-34 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 146 1e-33 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 144 4e-33 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 143 8e-33 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 142 1e-32 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 142 3e-32 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 139 1e-31 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 138 3e-31 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 138 3e-31 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 135 2e-30 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 135 3e-30 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 133 8e-30 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 133 1e-29 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 132 2e-29 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 132 2e-29 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 131 4e-29 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 130 1e-28 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 129 2e-28 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 129 2e-28 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 129 2e-28 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 128 3e-28 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 128 4e-28 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 128 4e-28 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 127 8e-28 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 126 1e-27 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 126 2e-27 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 125 2e-27 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 125 3e-27 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 124 4e-27 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 124 6e-27 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 122 2e-26 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 122 2e-26 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 121 4e-26 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 117 4e-25 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 117 5e-25 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 117 7e-25 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 115 2e-24 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 115 2e-24 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 112 2e-23 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 110 9e-23 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 110 1e-22 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 108 2e-22 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 108 4e-22 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 107 6e-22 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 107 8e-22 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 106 1e-21 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 105 2e-21 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 105 2e-21 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 105 3e-21 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 102 3e-20 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 101 4e-20 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 99 2e-19 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 99 2e-19 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 97 1e-18 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 95 4e-18 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 94 7e-18 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 94 8e-18 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 93 2e-17 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 92 2e-17 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 91 4e-17 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 89 2e-16 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 82 3e-14 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 70 1e-10 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 69 2e-10 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 69 3e-10 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 65 3e-09 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 64 6e-09 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 64 8e-09 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 59 2e-07 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 59 3e-07 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 58 4e-07 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 58 5e-07 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 58 5e-07 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 58 7e-07 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 57 1e-06 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 56 2e-06 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 56 2e-06 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 55 5e-06 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 54 1e-05 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 49 2e-04 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 49 4e-04 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 47 0.001 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 46 0.002 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 46 0.002 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 45 0.003 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 45 0.004 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 44 0.007 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 44 0.009 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 43 0.018 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 41 0.057 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 581 bits (1498), Expect = e-164, Method: Compositional matrix adjust. Identities = 277/359 (77%), Positives = 310/359 (86%), Gaps = 1/359 (0%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + RIAAIPGDGIG EVLPEGIRVL+AAA + G AL F+ EWASC+YY HGKMMPDDW Sbjct: 5 SFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWA 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 EQL ++DAIYFGAV WPD VPDHISLWGSLLKFRREFDQYVN+RPVRLFPGVPC LA ++ Sbjct: 65 EQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRK 124 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 GDIDF VVRENTEGEYSSLGG + E TE+E+VIQES+FTRRGVDRIL+YAF+LA+ R R Sbjct: 125 VGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRER 184 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVA 242 K +TSATKSNG+AISMPYWD+R EAMA +YP + WDKQHIDILCARFV+QPERFD VVVA Sbjct: 185 KHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVVVVA 244 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGPAC GTIGIAPSANLNPER FPSLFEPVHGSAPDI+GKNIANPIA IW Sbjct: 245 SNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIW 304 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 +GA+ML+FLG GDER+Q+AH+ +L AIE VIA G TPDM G +T QV AI + R Sbjct: 305 SGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDMGGTLSTQQVGAAISDTLAR 363 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 544 bits (1401), Expect = e-153, Method: Compositional matrix adjust. Identities = 254/358 (70%), Positives = 299/358 (83%), Gaps = 1/358 (0%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K RIA IPGDGIG EV+PEG+R L A + R+G ++E +EWASC+YY+ HG+MMPDDW Sbjct: 39 KVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDW 98 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 QLS DA+ FGAVGWP+TVPDHISLWGSL+KFRREFDQYVNLRP RLF GVPCPLAG+ Sbjct: 99 KTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGR 158 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + GDIDF +VRENTEGEYS++GG + EGTE E V+Q++VFTR G +R+L++AFELAQ R Sbjct: 159 KAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRA 218 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 ++ LT ATKSNG+AISMP+WD R MA YP++ WDKQHIDILCARFVMQP+RFDVVVA Sbjct: 219 KR-LTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDVVVA 277 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGPACTGTIGIAPSANLNPER FPSLFEPVHGSAPDI GK+IANPIA IW Sbjct: 278 SNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIW 337 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + AMM+DFLG G ++AH+ I+AAIE V+ HGP+T DM G A+T +V DAI +L Sbjct: 338 SAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLL 395 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 459 bits (1180), Expect = e-128, Method: Compositional matrix adjust. Identities = 225/360 (62%), Positives = 271/360 (75%), Gaps = 9/360 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +IA IPGDGIG EV+PEGIRVL+AA+ ++GF L+F +W SC Y G MMP D Sbjct: 5 QQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDW-SCARYHSQGSMMPSDG 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L DAI+ GAVG+P VPDH+SLW L+ RREFDQYVNLRPVRL PGVPCPLA K Sbjct: 64 IERLRDSDAIFLGAVGFPG-VPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANK 122 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +PGDIDF++VRENTEGEYS +GGR+ GTEHE V QE++FTRRG DRI+RYAF+LA+ Sbjct: 123 KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFDLAKKLG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +TSATKSNG+ SMP+WDER A+ YP+IR D+ HIDIL ARF M PERFDVVV Sbjct: 183 RNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPERFDVVVG 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGP TGTI +APSAN+NPER +PS+FEPVHGSAPDI G+ IANPI IW Sbjct: 243 SNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIW 302 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK--TPDMKGNATTPQVADAICKIIL 360 +GAMML+ LG +A I+ AIE V+ H + TPD+ G A+T Q+ I + +L Sbjct: 303 SGAMMLEHLGQ-----PEAAAAIMQAIETVLTHPDRVHTPDLGGRASTQQMGAEIARAVL 357 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 378 bits (971), Expect = e-103, Method: Compositional matrix adjust. Identities = 187/356 (52%), Positives = 242/356 (67%), Gaps = 11/356 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IAAIPGDG+GKEV+ +VL AAE G + SF W SC+YY HGKMMP+ Sbjct: 3 MKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPW-SCDYYLEHGKMMPE 61 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L++F+A++ GAVG P VPDHISLWG LLK RRE + +N+RP + G+ PL Sbjct: 62 DGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLL 121 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 P D DF V+REN+EGEYS +GGR++ G + E+ IQ +VFTR+ +R++R+AFELA+ Sbjct: 122 --HPNDFDFVVIRENSEGEYSEVGGRIHRGDD-EIAIQNAVFTRKATERVMRFAFELAKK 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R +TSATKSNG+ +MP+WDE + A +Y I QHID L A FV +PE FDV+ Sbjct: 179 R-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDIL+D+ + G+IGIAPSAN+NP +PS+FEPVHGSAPDI G+ +ANPI Sbjct: 238 VASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 IW +MLD G ++ IL +E+V A G KT D+ G +TT +V D IC Sbjct: 298 IWTAKLMLDHFGE-----EELGAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEIC 348 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 369 bits (947), Expect = e-101, Method: Compositional matrix adjust. Identities = 182/359 (50%), Positives = 244/359 (67%), Gaps = 8/359 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ +IAAIP DGIG EV+ G++VL+A +R G F++ E +W S +YY +G MMP Sbjct: 1 MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGS-DYYKKNGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL +FDAI+FGAVG PD VPDHI+LWG L + FDQY N+RP ++ PG+ PL Sbjct: 60 DGLEQLKKFDAIFFGAVGAPD-VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLR 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 PGD+D+ +VREN+EGEYS GGR ++G EV + ++FTR GV RI+RYAF+LAQ+ Sbjct: 119 NCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQA 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN M WDE +++ +P++ WDK +D + R ++P+ D + Sbjct: 179 RPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++G+AP+AN++PER FPS+FEP+HGSA DI GK IANP+AT Sbjct: 239 VATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVAT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 W A ML+ LG D A +++A+E V G TPD+ G A T QV DA+C+ I Sbjct: 299 FWTAAQMLEHLGEKD-----AATRLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAI 352 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 349 bits (895), Expect = 1e-94, Method: Compositional matrix adjust. Identities = 179/314 (57%), Positives = 213/314 (67%), Gaps = 6/314 (1%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT +A IPGDGIG +V + VL AAA + FA W SCEYY HG+MMP+D Sbjct: 1 MKTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPW-SCEYYLEHGRMMPED 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAIY GAVGWP TVPD +SL G LL R+ F+QY N+RP RL GV PL Sbjct: 59 GIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLKA 118 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGRV+EG +EV ++ SVFTR GV+RILR+ FE A+SR Sbjct: 119 E---GFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQARSR 175 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS TKSN SM +WDE +A YP++ HID + A+ VM P+ DVVV Sbjct: 176 -RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLDVVV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI GKNIANPIA I Sbjct: 235 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAI 294 Query: 302 WAGAMMLDFLGNGD 315 W+ A MLD LG + Sbjct: 295 WSVAQMLDHLGEAE 308 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 347 bits (891), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 185/358 (51%), Positives = 234/358 (65%), Gaps = 12/358 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M MR+A IPGDGIG +V E ++V+ +A G + + + ++ SCE Y+ G MMP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSAT---GGRIEWTEFDY-SCERYAKTGAMMPP 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L+ FDAI GAVG+P VPD +SLWG L+ RR F+QYVNLRPVRL PG+ PLA Sbjct: 57 DAPTTLAGFDAILLGAVGYPG-VPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLA 115 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + +VRENTEGEYS +GG N G ++E +QESVFTR G +RI+RYAFELA S Sbjct: 116 GVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAFELAAS 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + SATKSNG+ SMPYWD +A YP+ H+D L AR V P DV+ Sbjct: 176 AGFR-VCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPASLDVI 234 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDL A TG +G+A S N+NPERT S+FE VHGSAPDI G+ IANP+A Sbjct: 235 VASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQ 294 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICK 357 I AGAM+LD L N I A+++V++ G +TPD+ G ATT Q+ AI + Sbjct: 295 ILAGAMLLDHLNE-----PATANKIRLAVDQVLSDGRVRTPDLGGTATTEQLGTAIAE 347 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 345 bits (885), Expect = 1e-93, Method: Compositional matrix adjust. Identities = 177/362 (48%), Positives = 242/362 (66%), Gaps = 10/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M+ RIA +PGDGIG EV+ E ++VL+ ++ + F + W S EYY HG+MMP+ Sbjct: 1 MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNS-EYYLQHGRMMPE 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + L +DAI FGA+G P VPD IS+W ++ R+ F QYVNLRPV+ G+P Sbjct: 60 NGLDILKNYDAILFGAIGDP-RVPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFI 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 Q I+F +VREN EGEYS+ GGR+ +GT+ E+ +Q ++ TR+G +RI RYAF+ A+ Sbjct: 119 -HQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKK 177 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + +ATKSN + SM WDE +E +A YP+I+ +K +ID L A FV +P+ V+ Sbjct: 178 HGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDLG A G +GI+PSAN+NPE FPS+FEPVHGSAPDI GK ANPIA Sbjct: 238 VASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 IW+ A+ML LG D + IL AIE+V HG K T D+ GN+TT ++ + I + I Sbjct: 298 IWSAALMLQSLGRED-----LASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQI 352 Query: 360 LR 361 ++ Sbjct: 353 VK 354 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 345 bits (884), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 179/358 (50%), Positives = 228/358 (63%), Gaps = 9/358 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MKT RIA IPGDGIGKEV+P G + +Q AE G F F+ +W +YY HG MMP Sbjct: 1 MKTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGG-DYYRRHGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E L DAI FG+ G PD + DHI+LWG LK + DQY N+RP RL PG+ PL Sbjct: 60 DGLEPLRDKDAILFGSAGDPD-IADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLK 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D+ +VREN+EGEYS +GGRV++G E S+ TR GV+RILRYAF LAQS Sbjct: 119 RCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFRLAQS 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN +M WDE ++ +P++RWDK+ +D AR V +P D + Sbjct: 179 RPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPASLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++GIAP+ N++PER PS+FEP+HGSA DI GK +ANPI T Sbjct: 239 VATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICK 357 W+ M+L+ LG QA ++ A+E V A T D+ G ATT QV A+C+ Sbjct: 299 FWSVVMLLEHLGE-----HQAAARMMRAVESVTADQALHTRDLGGTATTEQVTQAVCQ 351 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 340 bits (873), Expect = 3e-92, Method: Compositional matrix adjust. Identities = 175/335 (52%), Positives = 217/335 (64%), Gaps = 10/335 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT RIA +PGDGIG++V VL+ A GF+L + W SC+YY +G MMP D Sbjct: 1 MKTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPW-SCDYYLENGSMMPAD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL PGV PL Sbjct: 60 GIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPL-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGR+++G ++EV I+ ++FTR+GV+RILR+ FE A++R Sbjct: 118 -RSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQARAR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L S TKSN SM +WDE ++ YP++ HID + AR VM PE DVV Sbjct: 177 -RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLDVVA 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG 336 W+GAMML+ LG A ++ AIE A G Sbjct: 296 WSGAMMLEHLGE-----TAAAEKVMDAIETTTARG 325 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 340 bits (871), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 174/359 (48%), Positives = 233/359 (64%), Gaps = 9/359 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 T RIA+IPGDGIG EV+ I+V++ A+ G F + F + W + YY HG+ + +D Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPWGTA-YYKEHGRYVSEDC 104 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L +FDA FGAVG PD VPDHISLWG LL R Y N+RPVR FPG CPL Sbjct: 105 LDTLRKFDAGLFGAVGAPD-VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPLNTA 163 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 G ID+ +VREN+EGEYS GGR + G E + ++FTR G++RI+R+AFE+AQSRP Sbjct: 164 TEG-IDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEVAQSRP 222 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK LT TKSN + M WD+ +A+++P++ WDK +D + R V +P+ D +V Sbjct: 223 RKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSIDTIVG 282 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NL DILSDL A G+IG+APS+NL+P R PS+FEPVHGSA DI GK +ANP+AT W Sbjct: 283 TNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFW 342 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + A ML +LG ++A ++ +E+V A G TPD+ G + T V DA+ K I R Sbjct: 343 SAAEMLSWLGE-----KEAAKQLMDCVEKVCAAGILTPDLGGTSNTQGVVDAVKKEIER 396 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 338 bits (867), Expect = 2e-91, Method: Compositional matrix adjust. Identities = 181/351 (51%), Positives = 216/351 (61%), Gaps = 10/351 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ IA IPGDGIG++V +VL A GF L+ W SC +Y G MMP D Sbjct: 1 MKSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPW-SCAFYKETGAMMPPD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L RFDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL GV PL Sbjct: 60 GIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLKA 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGRV++GT EV ++ S+FTR GV+RILR+ F+ A+ R Sbjct: 120 E---GFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQARQR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK L S TKSN SM WDE +A YP++ HID + AR VM PE DVVV Sbjct: 177 RRK-LASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLDVVV 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVA 352 W+GAMMLD LG +A ++ A+E A G T K T A Sbjct: 296 WSGAMMLDHLGQA-----RAARKVIEALERTTARGIGTVPGKNRTETITAA 341 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 324 bits (830), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 165/352 (46%), Positives = 225/352 (63%), Gaps = 12/352 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M + +PGDG+G EV+ E + L A +++ + W S +++ HG MMP D + Sbjct: 1 MNVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPWGSA-WWAEHGTMMPADAID 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L DAI GAVG P VPD +LWG +LK R+E D +VN+RP RL G+P PLAG+ P Sbjct: 56 VLRGHDAILMGAVGDP-AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAP 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D+D VREN+EGEY+ +GGRV+ G H+V I+ SVFTRRG +R++RYAF +A +R + Sbjct: 115 HDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASAR-KG 173 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L +ATKSN P+WDE V + +P + D+ +D L AR + P DVVVASN Sbjct: 174 VLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVVASN 233 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDIL+D+ A G +G+A SANL+P P+LFEPVHGSAPDI G+ IANP+ IW+ Sbjct: 234 LFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSA 293 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A+ML+ LG G + ++ A+E V GP+T D+ G ATT +V DA+ Sbjct: 294 ALMLEQLGAG-----EGSRRLMDALETVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 307 bits (786), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 163/339 (48%), Positives = 214/339 (63%), Gaps = 7/339 (2%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +IA IPGDG G E + EG++VL AAA + GFAL ++W EYY G+++P Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGG-EYYLRTGEVLPP 71 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL R+DAIY GA+G P+ P I G LL+ R E DQY+NLRPV+L+PGV P+A Sbjct: 72 DAVEQLKRYDAIYLGAIGHPEVRPG-ILEKGILLRLRFELDQYINLRPVKLYPGVETPIA 130 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 GK P DIDF VVRENTEG Y+ GG + GT EV IQ S+ TR+GV+R +R+AFE + Sbjct: 131 GKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAFEYCRK 190 Query: 181 R-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R+ +T K+N L + W+ + E YP+I D H+D +C V PE FDV Sbjct: 191 RGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNPEWFDV 250 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDI++DLG G +GIA NLNPE S+FEP+ GSAP GKN+ NP+A Sbjct: 251 IVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPEGV--SMFEPIGGSAPKYTGKNVINPLA 308 Query: 300 TIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHG 336 + AGAMML+ LG R ++A + A + +A G Sbjct: 309 AVCAGAMMLEQLGETGAAARIEEAVKKVCAGHLKSLAAG 347 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 303 bits (777), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 159/354 (44%), Positives = 227/354 (64%), Gaps = 15/354 (4%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG EV+ E ++ Q+ + + ++W ++Y GK++P D+ +Q Sbjct: 12 KIIVIPGDGIGVEVMSEAEKMFQS----LNLPIQRDYVDWG-IQHYLKTGKVVPIDYIDQ 66 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + ++DAI G++G P T+PD+++L L++ R++ DQ++ LRP + FPG+P PL + Sbjct: 67 VKQYDAILLGSLGDPRTLPDYVTLE-PLIQMRQQLDQFLCLRPAKHFPGIPTPL---KKC 122 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +ID VVREN+EGEYS++GG GT E I+ +V TRRG++R++RYAFE ++ R R Sbjct: 123 EIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEASRKR-RNH 181 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T ATKSN + M WD EA+A YP++ +K ++D L A V P +FDV+V SNL Sbjct: 182 VTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGSNL 241 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 F DI+SDL G++GIAPSAN+NPERTFPSLFEPVHGSA DI GK I +PI T+ A + Sbjct: 242 FCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRASS 301 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 MML+FLG +E I AI+ I T D+ G TT +V + I I Sbjct: 302 MMLEFLGYSEESVL-----IEEAIQSSILQKITTIDIGGTKTTNEVGNFIADYI 350 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 296 bits (758), Expect = 9e-79, Method: Compositional matrix adjust. Identities = 156/310 (50%), Positives = 201/310 (64%), Gaps = 2/310 (0%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+++A IPGDGIG EV+ EG++VL A A R G L + E + +++ G+++PD Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYELGAQRWHAT-GEVLPDAV 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L + DAI GAVG P TVP + G LL+ R F YVNLRPVRL+PGV PLAG Sbjct: 63 EEELRQHDAILLGAVGDP-TVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGV 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 P DID VVRE TEG Y+ +GG + +GT HE+ Q+SV TR GV+R++RYAF A RP Sbjct: 122 APEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERP 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 LT K N L + W V + YP++ D H+D FV QP RFDVVV Sbjct: 182 CHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVT 241 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI++DLG A G IG+A S N+NPE FPS+FEPVHGSAPDI G+ A+P ATI Sbjct: 242 DNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 303 AGAMMLDFLG 312 + ++ML+ LG Sbjct: 302 SVSLMLEHLG 311 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 283 bits (725), Expect = 5e-75, Method: Compositional matrix adjust. Identities = 150/357 (42%), Positives = 211/357 (59%), Gaps = 9/357 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +R+A IPGDGIG EV+ + L+AA E G L +W E Y G MP D Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGG-ERYLRQGAAMPPDA 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + DA+ FGAVG PD VP+H +WG ++ R++ D VNLRPVR FPGVP + + Sbjct: 65 ADLVKKTDAVLFGAVGRPD-VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKV--R 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +VRENTEGEY GG + G+ H++ I+ +V +RR ++R AF LA R Sbjct: 122 DTDGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFALAGRRS 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 + L TKSN + P WD V + E YP + + +D + AR + P DV++A Sbjct: 182 GR-LCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLA 240 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDL G +G+APSAN+ P+ P ++EPVHGSAPDI GK +ANP+A + Sbjct: 241 SNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +GAM+L+ LG+ D ++ + + + + H T D+ GNATT VA A+ + Sbjct: 301 SGAMLLEDLGHTDA-ARRVRDAVADTLRDTRHH---TADLGGNATTADVASAVLHTM 353 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 277 bits (708), Expect = 4e-73, Method: Compositional matrix adjust. Identities = 156/382 (40%), Positives = 219/382 (57%), Gaps = 32/382 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ I GDGIG EV+ EG +V+ AA E + F + + M + S ++Y G+ + + Sbjct: 1 MVSYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPF-SADHYVKTGETISES 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++LS++ AI+ G++G V + G LL R +DQYVNLRPV+L GV PL G Sbjct: 60 SLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH-----------------------EVVIQ 158 K DIDFYVVRENTE Y +GGR +GT E+ Q Sbjct: 120 KTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQ 179 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 V ++ G RI+ Y+F+LA SRP+K L+S K+N L +W E A YP+++ Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 D ++D + FV PE FDVVV+ N+FGDI++DLG G +G+AP N+NPE T S+ Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPEGT--SM 297 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 FEP+ GSAP G N NPIATIWAGAM+L+ LG +QA GI+ AIE+ + Sbjct: 298 FEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGE-----KQAAAGIVDAIEQNLKEKKI 352 Query: 338 KTPDMKGNATTPQVADAICKII 359 +T D+ G+A T V I +I+ Sbjct: 353 RTYDLGGSAGTSDVGTDIARIV 374 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 262 bits (670), Expect = 1e-68, Method: Compositional matrix adjust. Identities = 142/318 (44%), Positives = 191/318 (60%), Gaps = 13/318 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M +T+ +A +PGDGIG EV+ E +RVL+ A +L Q + + ++ G+++ D Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVP-ADVSLDTTQYPFGAG-HFLETGQILTD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGS------LLKFRREFDQYVNLRPVRLFPG 114 L++ DAI GAVG P L G LLK R FD Y+NLRP L PG Sbjct: 59 SDLAALAQHDAILLGAVGGD---PRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPG 115 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 V PLA PG +DF VVRE TEG Y+ GG + GTEHE+ + SV T GV+R +R+A Sbjct: 116 VASPLAA--PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFA 173 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 FELA+ R RK +T K+N L + W V+ +A +P++ D H+D V P Sbjct: 174 FELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDP 233 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 RFDV+V+ NLFGDI++DL A +G IG+A S N+NP FPS+FEPVHGSAPDI G+ Sbjct: 234 SRFDVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQK 293 Query: 295 ANPIATIWAGAMMLDFLG 312 A+P A I + A++LD LG Sbjct: 294 ADPTAAILSVALLLDHLG 311 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 257 bits (656), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 147/313 (46%), Positives = 191/313 (61%), Gaps = 10/313 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWH 63 MR+A IPGDGIG EV+ EG++VL+A A E + + G+++PD Sbjct: 1 MRLAVIPGDGIGPEVVAEGLKVLRAVAP------DVESTPYDLGASRWQRTGELLPDTVL 54 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 ++L R DAI GA+G P +VP I G LL+ R E D +VNLRP RLF GV PLA Sbjct: 55 DELRRHDAILLGAIGDP-SVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAA-- 111 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 PG ID VRE TEG Y GG + T HEV + S+ T GV+R++RYAFE A +RPR Sbjct: 112 PGAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALARPR 171 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 + LT K+N L + W VE ++ +PE+ QH+D FV P RFDV+V Sbjct: 172 RHLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVIVTD 231 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLFGDI++DL A TG IG+A S NL+ T PS+FEPVHGSAPDI GK +A+P AT+ + Sbjct: 232 NLFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLS 291 Query: 304 GAMMLDFLGNGDE 316 ++LD LG D+ Sbjct: 292 VGLLLDHLGRADQ 304 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 243 bits (620), Expect = 7e-63, Method: Compositional matrix adjust. Identities = 151/358 (42%), Positives = 203/358 (56%), Gaps = 26/358 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +I I GDGIG EV+P VL+A ++ F + Q W E + G +P+ Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEATGLKFEFVEA--QAGW---ETFERIGTSVPE 55 Query: 61 DWHEQLSRFDAIYFGAVGWP-DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 E ++ DA FGA P VP +G++ RR+ D + N+RP + P VP Sbjct: 56 ATLEAVTHTDATLFGAATSPTKKVP---GFFGAIRYMRRKLDLFANVRPAKHHP-VP--- 108 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +PG +D VVRENTEG Y EG E+ I ++V TR+ RI YA LA Sbjct: 109 -GSRPG-VDLIVVRENTEGLYVEQERSYLEG---EIAIADTVITRKASARIGEYAARLAA 163 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 SRPRK L A K+N L ++ + V A A +PE++ ID + V PERFDV Sbjct: 164 SRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPERFDV 223 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V +NLFGDI+SDL G +GIA S N+ + ++FEPVHGSAPDI GK IANP A Sbjct: 224 IVTTNLFGDIISDLTAGLVGGLGIAASGNIGIKH---AVFEPVHGSAPDIAGKGIANPAA 280 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 TI +G MMLD LG +A + AA+++V+ GP+TPD+ GNATT Q A+A+ + Sbjct: 281 TILSGVMMLDHLGE-----HEAARRVEAAVDKVLQEGPRTPDLGGNATTLQFAEAVAR 333 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 232 bits (592), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 138/355 (38%), Positives = 201/355 (56%), Gaps = 28/355 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI I GDGIG EV+P RVL+A G L F + E A E + G +P++ E+ Sbjct: 4 RICLIEGDGIGHEVIPAARRVLEAT----GLPLEFVEAE-AGWETFERRGTSVPEETVEK 58 Query: 66 LSRFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + A FGA P VP +G++ RR D Y N+RP + P+ G +P Sbjct: 59 ILSCHATLFGAATSPTRKVP---GFFGAIRYLRRRLDLYANVRPAK-----SRPVPGSRP 110 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 G +D +VRENTEG Y E +V I ++V +++ +RI R A +A+ RPRK Sbjct: 111 G-VDLVIVRENTEGLYVE-----QERRYLDVAIADAVISKKASERIGRAALRIAEGRPRK 164 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 TL A K+N L ++ + + V+ +A+++P + +D + VM+PERFDV+V +N Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GDILSDL G +G+APS N+ ++FEPVHGSAPDI GK IANP A I + Sbjct: 225 LLGDILSDLAAGLVGGLGLAPSGNIG---DTTAVFEPVHGSAPDIAGKGIANPTAAILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 AMMLD+LG ++A + A++ V+ GP+TPD+ G+ATT +A+ + + Sbjct: 282 AMMLDYLGE-----KEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEAL 331 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 224 bits (572), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 136/355 (38%), Positives = 194/355 (54%), Gaps = 33/355 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWHE 64 +I IPGDGIGKEV+ + +L+ L FE + A E +GK +PD+ E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEK------LDLPFEYSYYDAGDEALEKYGKALPDETLE 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA+ FGA G +T D I ++ RRE + N+RP + G+ C G Sbjct: 57 ACRKSDAVLFGAAG--ETAADVI------VRLRRELGTFANVRPAKAIEGIECLYPG--- 105 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D VVRENTE Y +G G E + V TR +RI RYAFELA+ RK Sbjct: 106 --LDIVVVRENTECLY--MGFEFGFGDVTEAI---RVITREASERIARYAFELAKREGRK 158 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K+N + + + + +A++YPEI+++ +ID C VM P RFDV+V +N Sbjct: 159 KVTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDI+SDL G +G+APSAN+ ERT ++FEPVHG+A DI GK IANP A I Sbjct: 219 MFGDIVSDLAAGLVGGLGLAPSANVG-ERT--AIFEPVHGAAFDIAGKGIANPTAMILTA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 MML G + + + A+E+ I G KTPD+ GN T + A+ + ++ Sbjct: 276 CMMLRHFG-----YVEEAKKVEEAVEKTIKEGKKTPDLGGNLKTMEFANEVASLL 325 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 222 bits (565), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 144/363 (39%), Positives = 196/363 (53%), Gaps = 33/363 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++ ++A +PGDGIG EV+ L+A G AL ++ W + ++ HG+MMP DW Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEALP---GPALVLTELGWPAHAWHRDHGEMMPADW 62 Query: 63 HEQLSRFDAIYFGAVGWPD--------TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 QL+ +DA+ GA+G P +PD +SL LL+ R+ D + RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSL-APLLQLRKGLDLWACERPAVPLAG 121 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 P PL+ + D V+REN+EGEY GGR+ GT E Q VFTR G +RI+R+A Sbjct: 122 APMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHA 181 Query: 175 FELAQSR----------PR---------KTLTSATKSNGLAISMPYWDERVEAMAENYPE 215 FE A R PR + TK N + + W E +A YP Sbjct: 182 FERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPG 241 Query: 216 IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP-ERT 274 I + ID C +FV QP +FDVVVASNL GDIL+DL G +G+APSANLNP +R+ Sbjct: 242 IATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRS 301 Query: 275 FPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 P LFEP HGSAPDI G + A+P A + A ML+++G D ++ + A+ E IA Sbjct: 302 VPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIA 361 Query: 335 -HG 336 HG Sbjct: 362 EHG 364 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 221 bits (563), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 140/359 (38%), Positives = 203/359 (56%), Gaps = 17/359 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M++ +A + GDGIG EV+ E ++VL E++GF L+F + + H G +P + Sbjct: 1 MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEF-FVGGAAIDHCGYPLPAE 59 Query: 62 WHEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + DAI FG+VG W + PD G+LL R+ F + NLRP L+ G+ Sbjct: 60 TLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKF 119 Query: 117 CPL-AGKQPGDIDFYVVRENTEGEY-SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 CPL A D VVRE T G Y GR EG++ + E V+ + ++RI R A Sbjct: 120 CPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTE-VYYKYEIERIARAA 178 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 FE A R +K +TS K+N L S+ W E V MA++YPE+ + +ID + + P Sbjct: 179 FEAAMKRNKK-VTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAP 236 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 E FDV++ SN+FGDI+SD TG++G+ PSA+LN E F L+EP GSAPDI GK I Sbjct: 237 ESFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLN-EAGF-GLYEPAGGSAPDIAGKGI 294 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVAD 353 ANPIA I + AMML + N +A + I +A+++V+A G +T D+ ++T A+ Sbjct: 295 ANPIAQILSAAMMLRYSFN----LNEAADAIESAVQKVLASGHRTADLADDSTPVSTAE 349 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 214 bits (546), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 135/366 (36%), Positives = 200/366 (54%), Gaps = 34/366 (9%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWH 63 M++ I GDGIGKEV+PE I++L E FE ++ A E +G +P+D Sbjct: 2 MKVCVIEGDGIGKEVIPEAIKILNELGE-------FEIIKGEAGLECLKKYGNALPEDTI 54 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGS-LLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+ D I FGA+ P P + + S ++ R+ F Y N+RP+ F G+ L GK Sbjct: 55 EKAKEADIILFGAITSPK--PGEVKNYKSPIITLRKMFHLYANVRPINNF-GIG-QLIGK 110 Query: 123 -------QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 +ID ++RENTE Y GR E E++ I E V TR+G +RI+R+AF Sbjct: 111 IADYEFLNAKNIDIVIIRENTEDLYV---GR--ERLENDTAIAERVITRKGSERIIRFAF 165 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A RK ++ K+N L I+ + E + ++Y I D +D + PE Sbjct: 166 EYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPE 224 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V +N+FGDILSD A G +G+APSAN+ ++ +LFEPVHGSAPDI GK IA Sbjct: 225 KFDVIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK---ALFEPVHGSAPDIAGKGIA 281 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP+A+I + AM+ D++G ++ + I A++ + + TPD+ G+ T V D I Sbjct: 282 NPMASILSIAMLFDYIGE-----KEKGDLIREAVKYCLINKKVTPDLGGDLKTKDVGDEI 336 Query: 356 CKIILR 361 I + Sbjct: 337 LNYIRK 342 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 214 bits (544), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 141/372 (37%), Positives = 191/372 (51%), Gaps = 33/372 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWHE 64 RIA +PGDGIG EV +RVL A G + E ++ A E + G P+ Sbjct: 14 RIAVVPGDGIGPEVSAATVRVLTQA---LGTSFPIEFRDYDAGAECFRRTGTAFPEATQV 70 Query: 65 QLSRFDAIYFGAVGWPDTV-PDHISLWGSL-LKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A+ GA G PD + PD +K R D Y N+RP+RL G P L GK Sbjct: 71 ACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA---Q 179 P DI F +VRENTEG Y++ GG ++ V TR GV+RI+RYA ELA Q Sbjct: 131 GPDDIRFTIVRENTEGLYAARGG--GNIIRGQIATDTLVMTREGVERIVRYAAELARDGQ 188 Query: 180 SRPR---KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 P + +T K+N L S ++ E + + + P I + +D + + +PE Sbjct: 189 GAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERPEH 247 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V NLFGDILSDLG A G +G+APS + + + F+ HGSAP I GK +AN Sbjct: 248 FDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRDHGY---FQGSHGSAPTIAGKGLAN 304 Query: 297 PIATIWAGAMMLDFLGN---------GDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 PIA I +GAMMLD+LG ER ++A +L A V TPD+ G+ + Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAV------TPDIGGSGS 358 Query: 348 TPQVADAICKII 359 T A IC + Sbjct: 359 TESCAAEICATL 370 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 214 bits (544), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 136/357 (38%), Positives = 201/357 (56%), Gaps = 31/357 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA-SCEYYSHHGKMMPDDWH 63 MR+A I GDGIG+E++P ++VL A F L FE++ + G + ++ Sbjct: 1 MRLAVIEGDGIGREIIPAAVKVLDA------FGLEFEKVPLELGYTRWERTGTAISNNDL 54 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + DA+ FGA+ TVPD + LL R+E D Y N+RPV+ PG+ + G+ Sbjct: 55 ETIKGCDAVLFGAI---TTVPDP-NYKSVLLTIRKELDLYANVRPVKPLPGI-TGVTGRN 109 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 D DF +VRENTEG YS + E E+ + V TR+G +RI YA +LA+ R Sbjct: 110 --DFDFIIVRENTEGLYSGI-----EEIGPELSWTKRVVTRKGSERIAEYACKLAKKRKN 162 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K LT KSN L + D + + N + ++ +D + +M+PER+D+VV + Sbjct: 163 K-LTIVHKSNVLKSDKLFLDVCRQTASAN--GVEYEDMLVDSMAYNLIMRPERYDIVVTT 219 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLFGDILSD+ A G++G+ PSAN+ + F FEPVHGSAPDI GK IANP+A I Sbjct: 220 NLFGDILSDMCAALVGSLGLVPSANIGEKYAF---FEPVHGSAPDIAGKGIANPLAAILC 276 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 M+L+++ G+ R Q I +++ I TPD+ G A+T +V +A+ + +L Sbjct: 277 VKMLLEWM--GEPRSQIIDEAIAYVLQKKII----TPDLGGTASTMEVGNAVAEYVL 327 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 211 bits (537), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 141/369 (38%), Positives = 194/369 (52%), Gaps = 31/369 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG+EV+P + VL+A G FE + A E + G+ +P Sbjct: 8 ILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENAD-AGWECFQRQGEALPSATLTAA 62 Query: 67 SRFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 DAI FGAV P V + S +++ RRE D Y N+RPV F +P + + Sbjct: 63 RAADAILFGAVASPGYPVAGYRS---PIVRLRRELDLYANIRPV--FDDLPENGSNPRRR 117 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR---- 181 +D VVRENTE Y+ GR + I E V TRR RI+R A +LA++R Sbjct: 118 KVDLVVVRENTEDVYA---GRERVEDDGATAIAERVITRRASARIMRVACDLARARRSAR 174 Query: 182 -----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 P +T K+N L + + +A+ YP+++ D+ +D + +PER Sbjct: 175 NGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATRPER 234 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V +NLFGDILSD+ A G +G+APSANL +LFEPVHG+APDI GK IAN Sbjct: 235 FDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH---ALFEPVHGAAPDIAGKGIAN 291 Query: 297 PIATIWAGAMMLDFL-GNGDERFQQAHNGILAAIEEVIAH----GPKTPDMKGNATTPQV 351 P+A I A++LD L G A G A I+ I H GP TPD+ G+A T + Sbjct: 292 PLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVTTDI 351 Query: 352 ADAICKIIL 360 +A+ +L Sbjct: 352 TNAVLSHML 360 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 209 bits (533), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 138/368 (37%), Positives = 202/368 (54%), Gaps = 37/368 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K++ I IPGDGIGKEV+P G +VL+ + G + +F + +A + + GK +PD+ Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDL-YAGFQTFQETGKALPDET 80 Query: 63 HEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L + FGAV P T + S ++ RRE + N+RPV+ + G Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKVEGYS--SPIVALRREMGLFANVRPVK-------SVEG 131 Query: 122 KQPGDIDFYVVRENTEGEY---------SSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 ++ ID +VRENTE Y + G RV + T+ I E + TRR L Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKR---ISE-IATRRIATIALD 187 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYW----DERVEAMAENYPEIRWDKQHIDILCA 228 A + Q+R + TLT KSN L+ S + E E+ + Y +I++++Q +D + Sbjct: 188 IALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVY 247 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 R +P+ FDV+VA NL+GDILSD A G++G+ PSAN+ PE + EP HGSAPD Sbjct: 248 RLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPEIV---IGEPCHGSAPD 304 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNAT 347 I GK IANPIATI + A+ML+FLG+ +A I A++ + G KTPD+ G A+ Sbjct: 305 IAGKGIANPIATIRSTALMLEFLGH-----NEAAQDIYKAVDANLREGSIKTPDLGGKAS 359 Query: 348 TPQVADAI 355 T QV D + Sbjct: 360 TQQVVDDV 367 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 204 bits (520), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 128/362 (35%), Positives = 193/362 (53%), Gaps = 19/362 (5%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF-ALSFEQMEWASCEYYSHHGKMMPDDW 62 T+ IA +PGDGIG+EV+P + ++ AA G AL+F Q A +YY+ G +P Sbjct: 7 TLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAF-QTHNAGAQYYAESGDALPAST 65 Query: 63 HEQLSRFDAIYFGAVGWPDT-VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + DAI FGA+GWPD PD + L R E + +RP+R FPG+P L Sbjct: 66 LDACRKSDAILFGAMGWPDIRFPDGTEIIPQ-LDLRMELGLFAGVRPIRWFPGLPRVLTD 124 Query: 122 KQPGDIDFYVVRENTEGEYSSLG-GRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + IDF +VRE TEG + + G G + E +Q TR G R+ +AF++A+ Sbjct: 125 PRAEQIDFVLVREQTEGLFYARGRGEIRNDEEAYDTMQ---ITRSGTQRVTEFAFDIARQ 181 Query: 181 RPRK----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 R R+ +T K+N SM ++ + + +A+ + ++ D ++D L V +P Sbjct: 182 RKRRGKPGNVTCVDKANVFQ-SMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKPWT 240 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V N+FGDILSDL G +G+APSA++ + LF+P HG+APDI GK AN Sbjct: 241 FDVLVTENMFGDILSDLAAGLIGGMGMAPSADIGDKH---GLFQPAHGTAPDIAGKGCAN 297 Query: 297 PIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVAD 353 P A + AMMLD+L G A + A+E ++ P + GNA ++ Sbjct: 298 PSAMFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPMEYGGNANCAEMTR 357 Query: 354 AI 355 ++ Sbjct: 358 SV 359 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 204 bits (519), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 125/357 (35%), Positives = 181/357 (50%), Gaps = 33/357 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA-SCEYYSHHGKMMPD 60 MK+M+IA IPGDGIG EV+ + +L L F + +C G +P+ Sbjct: 1 MKSMKIAVIPGDGIGVEVMEAALHILNT----LDLDLEFIHADAGDAC--LKRTGTALPE 54 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + A FGA G S +++ RREFD + NLRPV+ PGVPC Sbjct: 55 ETLEAVGEARATLFGAAGE--------SAADVIVRLRREFDLFANLRPVKSLPGVPCLYP 106 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D+DF +VRENTE Y +E E + + + TR RI ++AF+ AQ Sbjct: 107 -----DLDFVIVRENTEDLYVG-----DEEYTPEGAVAKRIITRTASRRISQFAFQYAQK 156 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + +T+ K+N L + + + +A YP++ ++D + QP+ F + Sbjct: 157 EGMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTI 216 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDILSD G +G+APSAN+ + +LFEPVHGSAP I GKNIANP A Sbjct: 217 VTTNLFGDILSDEAAGLIGGLGLAPSANIGEKN---ALFEPVHGSAPQIAGKNIANPTAM 273 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 I +ML L +Q I A+++ +A G TPD+ G T ++A I + Sbjct: 274 ILTTTLMLKHLNK-----KQEAQKIEKALQKTLAEGLVTPDLGGKLGTMEMAAEIAR 325 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 203 bits (517), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 139/362 (38%), Positives = 195/362 (53%), Gaps = 37/362 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS-CEYYSHHGKMMPDDW 62 T +I IPGDGIG EV +RVL+A L FE +A+ E Y + + +P + Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEATG------LKFEWESFAAGAEAYEKYKEYIPKEL 55 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 +E + R G G P T P ++ R+ F+ Y N+RP+R PGV + Sbjct: 56 NESIER---TRIGLKG-PVTTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHT----R 107 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV--IQES--VFTRRGVDRILRYAFELA 178 PG +D VVRENTEG YS G EHEVV + ES + T + RI ++AF A Sbjct: 108 YPG-VDLVVVRENTEGLYS--------GIEHEVVPGVVESLKIITEKASTRISKFAFNYA 158 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + RK + S K+N + +S + +++ YPEI + + +D C + VM P ++D Sbjct: 159 RKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYD 218 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 +++ NL+GDI+SDL G +G+AP AN+ ER S+FE VHGSAPDI GKNIANP Sbjct: 219 ILLLENLYGDIVSDLCAGLVGGLGLAPGANIG-ERA--SIFEAVHGSAPDIAGKNIANPT 275 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICK 357 A I +G +ML L DE Q A N + AA+ V G T DM G +T + AD + + Sbjct: 276 AVIRSGILMLRHL---DE--QDAANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVE 330 Query: 358 II 359 I Sbjct: 331 AI 332 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 202 bits (514), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 129/334 (38%), Positives = 180/334 (53%), Gaps = 35/334 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ RI IPGDGIG EV + ++V++AA +GF+L + + E+Y +++PD Sbjct: 1 MKSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPYGA-EHYLSTRQVLPDH 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E++ DA+ GA+G P P I G LLK R FDQY N+RPVR F P PL Sbjct: 60 ALEEMEGLDALLLGAIGDPRVQPG-ILERGILLKLRFHFDQYANIRPVRSF--TPGPL-- 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLG----GRVN---EGTEHEVVI--QESVFTR-------- 164 G ++ V+RENTE Y +G G VN E T V+ Q S FT Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 165 ------RGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 G R +YAF+LA + +T ATKSN + ++ +A Y + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++D LC + V P F V++ N+FGDI+SDL G +G+APS N+ S+ Sbjct: 232 RVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDRL---SM 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 FEPVHGSAPDI G++ ANP+A+I +GAM+L LG Sbjct: 289 FEPVHGSAPDIAGQDRANPVASILSGAMLLRHLG 322 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 200 bits (508), Expect = 8e-50, Method: Compositional matrix adjust. Identities = 131/361 (36%), Positives = 192/361 (53%), Gaps = 23/361 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M++A +PGDGIG EV ++VL+A E G L++E + G+ P+ + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGA-AIDAFGEPFPEPTRK 59 Query: 65 QLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 + +A+ G+VG P D +P I LL R+ D + NLRP ++FPG+ PL Sbjct: 60 GVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D +VRE T G Y G +E E E +++ V+R+ R AFE A+ Sbjct: 120 EEIARGVDVLIVRELTGGIYF---GEPRGMSEAEAWNTER-YSKPEVERVARVAFEAARK 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R RK + S K+N L + +W + VE + YP++ + Q++D + V P RFDVV Sbjct: 176 R-RKHVVSVDKANVLEVG-EFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVV 233 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V N+FGDILSDL G++G+ PSA+L R P +FEPVHGSAPDI GK IANP A Sbjct: 234 VTGNIFGDILSDLASVLPGSLGLLPSASLG--RGTP-VFEPVHGSAPDIAGKGIANPTAA 290 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 I + AMML+ E ++ + + A+ E PD+ G+A T +A +L Sbjct: 291 ILSAAMMLEHAFGLVELARKVEDAVAKALLET-----PPPDLGGSAGT----EAFTATVL 341 Query: 361 R 361 R Sbjct: 342 R 342 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 199 bits (507), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 116/298 (38%), Positives = 165/298 (55%), Gaps = 8/298 (2%) Query: 19 VLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSR-FDAIYFGAV 77 V+ E +L+ ER G + +++ + + Y G P+ + R A+ GA+ Sbjct: 21 VIAEAKLLLELYQERAGLPIDLWELDLGA-DRYLRDGTTFPNQIQIAIQRECSAVLLGAL 79 Query: 78 GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE 137 G P VP+ L R +D Y N+RPVR PL G+ DIDF V RENTE Sbjct: 80 GDP-RVPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFRENTE 138 Query: 138 GEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 G Y +GG+ GT EV I E V TR+GV+RI+R AF+ A++ R +T A KSN + Sbjct: 139 GIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMADKSNAMRH 198 Query: 198 SMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + W + YPEI+ + ++D LC + P +F V+V +NLFGDI++DLG A Sbjct: 199 AHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGAAL 258 Query: 258 TGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 G +G+A SAN+ +P R +LFEPVHGSAP + GK+IANP A + ++L LG Sbjct: 259 QGGLGMAASANVHASDPARV--ALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLG 314 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 197 bits (500), Expect = 6e-49, Method: Compositional matrix adjust. Identities = 129/364 (35%), Positives = 201/364 (55%), Gaps = 27/364 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQM-EWASCEYYSHHGKMMPDDWH 63 M+IA +PGDGIG EV+ E ++VL+ ++ G +FE++ + G+ +P++ Sbjct: 1 MKIAVLPGDGIGPEVVREALKVLEVVEKKTG--KTFEKVFGHIGGDAIDRFGEPLPEETK 58 Query: 64 EQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + DAI+ G+VG W D P+ G LL R+ + Y N+RP++++ + P Sbjct: 59 KICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSP 118 Query: 119 LAGKQPGD-IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 L K G +D VRE + G Y G + E ++ R+ V+RI R AFE+ Sbjct: 119 LKEKVIGSGVDLVTVRELSYGVYYGQ----PRGLDEEKGFDTMIYDRKTVERIARTAFEI 174 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A++R RK +TS K+N L SM W + V +A YP++ ++D + +++P +F Sbjct: 175 AKNR-RKKVTSVDKANVLYSSM-LWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQF 232 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV++ +N+FGDILSD A G++G+ PSA+ + +L+EP GSAPDI GKNIANP Sbjct: 233 DVILTTNMFGDILSDESAALPGSLGLLPSASFGDK----NLYEPAGGSAPDIAGKNIANP 288 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVAD 353 IA I + AMML+ E ++ I A+E VI G +T D+ + +T Q+ D Sbjct: 289 IAQILSLAMMLEHSFGMVEEARK----IERAVELVIEEGYRTRDIAEDPEKAVSTSQMGD 344 Query: 354 AICK 357 ICK Sbjct: 345 LICK 348 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 195 bits (495), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 119/360 (33%), Positives = 193/360 (53%), Gaps = 21/360 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I I GDGIG EV+ + I+ L + R+ S++ + A + G MP + + Sbjct: 5 IVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNV-LAGAKAIETFGDPMPKETIDSC 63 Query: 67 SRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-PCPLAGKQ 123 + DA+ FG++G P D+ P + LLK R+E D Y N+RP+ +PG+ P+ ++ Sbjct: 64 LKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSPIKERK 123 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++F + RE T G Y GR G E V++ + ++RI +F+ A+SR R Sbjct: 124 LEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSFKAARSRNR 180 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T K+N L S W E ++ MA +Y ++ + +ID + ++ P +FDV++ Sbjct: 181 K-MTLVDKANVLETSR-LWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKFDVILTD 238 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 N+FGDILSD T ++G+ PSA++ ++ SLFEP+HGS P GKNIANP+ I + Sbjct: 239 NMFGDILSDEASILTSSLGLLPSASIGSKK---SLFEPIHGSYPQAKGKNIANPLGCILS 295 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADAICKII 359 +MML++ Q N + A++ I TPD+ + +++T +V D I K I Sbjct: 296 VSMMLEYF-----EMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDYIEKYI 350 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 194 bits (492), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 123/366 (33%), Positives = 187/366 (51%), Gaps = 31/366 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + ++ +PGDGIG EV+ + +L+A AE G +++ Y H + P+D Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 64 EQLSRFDAIYFGAVGWPDTVPD----------HISLWGSLLKFRREFDQYVNLRPVRLFP 113 + D I GAVGWP PD +++ +++ R + D Y N+RPV+L P Sbjct: 69 ARCRGADVILLGAVGWPS--PDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLP 126 Query: 114 GVPCPLAGKQ-----PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVD 168 GV ++G + P +D ++RENTEG Y+ +GG++ G V + TRRG + Sbjct: 127 GVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCE 186 Query: 169 RILRYAFELAQSRPR-------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQ 221 RI+R AFEL + R R K +T K N L + E +A YP+I + Sbjct: 187 RIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVASEYPDIANELA 245 Query: 222 HIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP 281 +D V QPE +DV V +NLFGDI++DL G +G+A N+ E ++FEP Sbjct: 246 IVDAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEH---AMFEP 302 Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHG-PK 338 +HGSAP + GK+ ANP+A + A L +LG + D R + + + A+ V G P Sbjct: 303 IHGSAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPL 362 Query: 339 TPDMKG 344 T D+ G Sbjct: 363 TVDLVG 368 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 192 bits (489), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 131/365 (35%), Positives = 192/365 (52%), Gaps = 20/365 (5%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I IPGDGIGKE+ + VL+ E++G LS+ + A Y G +PDD Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKD-AGGTAYDKFGTPLPDDTI 60 Query: 64 EQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 E D + FGAVG W D V + ++L R+ Y NLRPV++ + P Sbjct: 61 EACKASDGVLFGAVGGDKW-DNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L + +D +VRE G Y + E ++ VDRI + AFE A Sbjct: 120 LKPELVKGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETA 179 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R +TS K+N LA S W V +AE+YP++ + ++D + ++P +FD Sbjct: 180 KLR-RGKVTSVDKANVLATSR-LWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFD 237 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V NLFGDILSD G+IG+ PSA++ T SL+EP+HGSAPDI GK IANP+ Sbjct: 238 VIVTGNLFGDILSDEAAVVGGSIGMMPSASIG---TSTSLYEPIHGSAPDIAGKGIANPM 294 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KG--NATTPQVADA 354 TI + AM+L + + A I AA+++ +A G +TPD+ +G A T ++ Sbjct: 295 GTILSAAMLLRY----SLHEEAAAKAIEAAVDKALADGYRTPDLWKEGFQKANTEEITKV 350 Query: 355 ICKII 359 IC+ I Sbjct: 351 ICERI 355 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 192 bits (488), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 128/340 (37%), Positives = 182/340 (53%), Gaps = 27/340 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPD 60 M RI I GDGIG E++ +RVL A AE + +E +E A + Y G + Sbjct: 1 MTGTRIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAE 60 Query: 61 -DWHEQLSRFDAIYFGAVGWPDT-VPDHI--SLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 D DA G VG PD PD + + G +L R D Y N+RPVR +PGVP Sbjct: 61 ADVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGIL--RTGLDTYANIRPVRSWPGVP 118 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFT-RRGVDRILRYAF 175 + + +D+ +VRENTEG Y+S G +G + + +++ T R G R+ R AF Sbjct: 119 SRVRADR---VDYVIVRENTEGLYASRG----KGVGNRWAVTDTLLTTREGTLRVARKAF 171 Query: 176 ELAQSRPR------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 LA R + +T KSN L S ++ E V +A +PE+ + ++ D Sbjct: 172 TLAAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVELEYRYADAAAQD 230 Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V+ PERFDV+V N GD+LSDLG A G +G+ P+ N+ + FEPVHGSAPD+ Sbjct: 231 LVLCPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGDGAAY---FEPVHGSAPDL 287 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDE--RFQQAHNGILA 327 G+N ANP+ + A AM+LD LG+ DE R ++A + +LA Sbjct: 288 VGRNRANPVGQLLAAAMLLDHLGHVDEAARLRRAVSAVLA 327 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 192 bits (487), Expect = 2e-47, Method: Compositional matrix adjust. Identities = 124/364 (34%), Positives = 187/364 (51%), Gaps = 27/364 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I + GD IG E++PE +RV+QAAA R G A+ ++ + S G +PD E Sbjct: 1 MKIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPIGRAALDSL-GSTLPDGTIE 59 Query: 65 QLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 +L D G +G +P +P+ I+ L R+ FD + N+RPV+ +PC G Sbjct: 60 RLDALDGWLLGPIGHMAYPK-IPEAINPHPLL---RKHFDLFANIRPVKSHAALPCLHQG 115 Query: 122 KQPGDIDFYVVRENTEG---EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 +D +VREN EG + + + G +V I V TR G ++ R AFELA Sbjct: 116 -----VDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFELA 170 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R R+ LT+ K + + E +A YP++ +D+ +D R VM P+R+D Sbjct: 171 RAR-RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYD 229 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVV +N+FGDIL+D G +G+A P ++ + HGSAPDI G+ IANP Sbjct: 230 VVVTTNMFGDILTDEAAGLVGGLGMAAGLCAGPRH---AMAQATHGSAPDIAGRGIANPY 286 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-----TPDMKGNATTPQVAD 353 A I +G M+LD+LG L IE+ +A+ + TPD+ G TT + Sbjct: 287 AMIMSGQMLLDWLGRRHAEPAATAAARL--IEQAVANMIEERRALTPDLGGQGTTAGMGS 344 Query: 354 AICK 357 AI + Sbjct: 345 AIIE 348 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 191 bits (484), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 127/355 (35%), Positives = 175/355 (49%), Gaps = 15/355 (4%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG EV+ + VL A G + ++ + + Y G+ + +++ Sbjct: 22 IAVIPGDGIGPEVIEPALDVLDA----LGLGTRTDILDHVNADTYLRTGEALTGSDLDRI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +A GAVG P + D + G L R E D YVN RP RL+ PL Sbjct: 78 RSSEAALLGAVGDP-RLGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARRA 136 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID +VRENTEG YS +GG GT E+ + + TR GV R+L +AF A R+++ Sbjct: 137 IDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA----RRSV 192 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 K+N + W +P I ++D R P FDV+V +N + Sbjct: 193 CLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNSY 252 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSDL A G +G+A SANLNP T +LFEPVHGSAPDI G ANP I + A+ Sbjct: 253 GDILSDLTAALAGGLGVAASANLNPV-TGRALFEPVHGSAPDIAGSGTANPFGAILSVAL 311 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + + LG +E A+ +A G TPD+ G T +V A+ + R Sbjct: 312 LAEHLGRNEEADAVR-----RAVAAAVAAGRVTPDLGGPLGTKEVGAAVLAELRR 361 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 190 bits (483), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 133/351 (37%), Positives = 187/351 (53%), Gaps = 31/351 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +IA IPGDGIGKEV+ I VL + + A E HG +P + + Sbjct: 12 QIAVIPGDGIGKEVMEATISVLDELDVDFDYIYGI-----AGDECNEEHGTPLPQETIDI 66 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA FGA G +T D I +K R+E + NLRPV+ +P Sbjct: 67 VRDSDACLFGAAG--ETAADVI------VKIRQEMKMFANLRPVKSYPNTKSLFE----- 113 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ++DF +VRENTEG Y + E TE + I + V TR +RI+ YAF+ A+ R Sbjct: 114 NVDFMIVRENTEGLYIA---DQEEETE-DGAIAKRVITREAEERIIDYAFQYAKDNNRTK 169 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N L + + + + E YP+I + ++D V QP+ F VVV +NL Sbjct: 170 VTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQVVVTTNL 229 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSD G G +G+ PSAN+ + +LFEPVHGSAPDI G+ ANPIA + + Sbjct: 230 FGDILSDEGAGLVGGLGLIPSANIGAD---GALFEPVHGSAPDIAGQQKANPIAMMLSAI 286 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAI 355 MML +LG D A + AAI +V++ G T D+ G+ATT +VA A+ Sbjct: 287 MMLRYLGEND-----AADKFDAAILKVLSEGKTLTGDLGGSATTMEVAQAV 332 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 190 bits (482), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 127/348 (36%), Positives = 180/348 (51%), Gaps = 20/348 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 142 KRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCAL-DLTGVPLPEET 200 Query: 63 HEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ GA+G W D+ H+ LL+ R + NLRP + P + Sbjct: 201 LLVAKQSDAVLLGAIGGYKW-DSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 118 PLAGKQPGDIDFYVVRENTEGEY--SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 L + +D VVRE T G Y G NE E E+ V+ +DRI R AF Sbjct: 260 TLKKEVAEGVDLMVVRELTGGIYFGKPRGFSKNENGE-EIGFNTEVYATYEIDRIARIAF 318 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E AQ R R L S K+N L SM W +RV AMA YP++ ++D + V P+ Sbjct: 319 ETAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPK 376 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FD +V +N+FGDILSD TG+IG+ PSA++ + P LFEP+HGSAPDI G++ A Sbjct: 377 QFDTIVTNNIFGDILSDEASMITGSIGMLPSASVG--ESGPGLFEPIHGSAPDIAGQDKA 434 Query: 296 NPIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 NP+AT+ + AM+L + LG G+ A I A+ + + G +T D+ Sbjct: 435 NPLATVLSAAMLLRYGLGEGN-----AAKRIETAVLDTLDRGFRTRDI 477 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 190 bits (482), Expect = 7e-47, Method: Compositional matrix adjust. Identities = 121/356 (33%), Positives = 187/356 (52%), Gaps = 25/356 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K R+A I GDG+G +V+ + VL A +++ + + A +G +P + Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPA-VAGLNTVEKYGTNLPKET 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHI-SLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L D + G P T P+ SL + + R+ FD Y ++RP + P VP Sbjct: 63 LDTLKETDCVLKG----PTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPNVPSI--- 115 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +P ++D +VRENTEG YS L RVN+ E I V TR+ +RI++YAF+LA+SR Sbjct: 116 -KP-NVDMVIVRENTEGMYSGLDFRVNQ----ETTIGIRVITRKACERIVKYAFKLAESR 169 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 +K +T K N L +S + + A+ +P+++ D H+D + F+ QPE +DV+V Sbjct: 170 -KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFYDVIV 228 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDI+SD G IG SAN+ + ++FEP+HGS P G + NPI TI Sbjct: 229 TENLFGDIISDEAAMVVGGIGTGASANIGDKY---AMFEPIHGSVPKYTGMDKVNPIGTI 285 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAIC 356 + MMLD++ +++A I A+ +V+ G T D+ G A +V I Sbjct: 286 MSVKMMLDWM-----DYKEAGKAIEDAVYKVLEEGKILTYDLGGTAKCSEVGKEIA 336 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 189 bits (481), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 126/347 (36%), Positives = 182/347 (52%), Gaps = 18/347 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDGIG EV+ VLQ A G F++M G +P++ Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAAL-DLVGVPLPEET 103 Query: 63 HEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 DAI GA+G W D H+ +L RR+ + NLRP + P + Sbjct: 104 FTAAKLSDAILLGAIGGYKW-DKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDAS 162 Query: 118 PLAGKQPGDIDFYVVRENTEGEY--SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 L + +D +VRE T G Y G +NE E EV + ++ +DRI R AF Sbjct: 163 TLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGE-EVGVSTEIYAAHEIDRIARVAF 221 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+ R R L S K+N L S+ W +RV A+A YP++ ++D + + P+ Sbjct: 222 ETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPK 279 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FD +V +N+FGDILSD TG+IG+ PSA+L + P LFEP+HGSAPDI G++ A Sbjct: 280 QFDTIVTNNIFGDILSDEASMITGSIGMLPSASLG--ESGPGLFEPIHGSAPDIAGQDKA 337 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 NP+ATI + AM+L + G G+E+ A I A+ + + G +T D+ Sbjct: 338 NPLATILSAAMLLKY-GLGEEK---AAKRIEDAVVDALNKGFRTGDI 380 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 189 bits (479), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 124/314 (39%), Positives = 166/314 (52%), Gaps = 47/314 (14%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +IAAI GDGIG EV+ G Q+A E ++ W + S Sbjct: 17 KIAAIRGDGIGPEVIEAG--NYQSAEET-------NRVAWILLNWPSR------------ 55 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLR------PVRLFPGVPCPL 119 GAV D + S + F Y+ LR P R+F G+ PL Sbjct: 56 ------TLSGAVRITRNTADISPISSSTFLW---FSSYLPLRSSTSNMPTRVFHGIQSPL 106 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 +D+ +VREN+EGEY+ GGR G EV S+FTR GV+RI+++AFE A+ Sbjct: 107 ------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAAR 160 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEA-MAENYPEIRWDKQHIDILCARFVMQPERFD 238 SR +K +T ATKSN + WDE A +A +P++ DK +D + AR V+ PE D Sbjct: 161 SRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPESLD 220 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 +V +NL ILSDL A G+IGIAP++NL+P R PS+FEPVHGSA DI GK+ + Sbjct: 221 TIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKD----L 276 Query: 299 ATIWAGAMMLDFLG 312 AT W A ML +LG Sbjct: 277 ATFWTVAEMLSWLG 290 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 188 bits (477), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 129/367 (35%), Positives = 195/367 (53%), Gaps = 34/367 (9%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA------AERWGFALSFEQMEWASCEYYSHHGKMMPD 60 I IP DGIGKEV+P ++V+ AA A++ F+L + +E A E + GK +P Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLE-AGWETFQKTGKSLPV 92 Query: 61 DWHEQL-SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVR-LFPGVPCP 118 + E L ++ D FG+V P + S ++ R+ D Y N+RP + L G Sbjct: 93 ETVEALKNKCDGAIFGSVQSPSHKVEGYS--SPIVAMRKLVDLYANIRPCQDLAKG---- 146 Query: 119 LAGKQPGDIDFYVVRENTEGEY-SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 ID +VRENTE Y V+ T + + + + T R RI A++L Sbjct: 147 --------IDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEIAYKL 198 Query: 178 AQSRPRK---TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 A R + +T KSN L++S + E +++ YP+++ ++Q +D + + ++ P Sbjct: 199 AVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKMILDP 258 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 ++DVVVA NL+GDILSD G A G +G+ SANL+ +F +L EPVHGSAPDI+GK I Sbjct: 259 TQYDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSD--SF-ALVEPVHGSAPDIFGKKI 315 Query: 295 ANPIATIWAGAMMLDFLGNGDER---FQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQ 350 +NPIATI A AM+L L D + + + + A+ V+ TPD+ G T Sbjct: 316 SNPIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGNTET 375 Query: 351 VADAICK 357 + DAI K Sbjct: 376 LVDAIIK 382 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 187 bits (475), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 126/363 (34%), Positives = 186/363 (51%), Gaps = 29/363 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW--ASCEYYSHHGKMMPDD 61 T I A+PGDGIG E+L + +L+ + ++ F E E+ AS + + G+ + + Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTF---GEPLTEK 58 Query: 62 WHEQLSRFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC--P 118 R DAI GA+G P T P++ G LLK R+ + + N+RP + G P Sbjct: 59 TLNACKRADAILLGAIGGPKWTDPNNRPEQG-LLKLRKSLNLFANIRPTTVVKGASSLSP 117 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L ++ D +VRE T G Y G HE + +TR ++RI+ AF+LA Sbjct: 118 LKAERVEGTDLVIVRELTSGIYF---GEPRYFNNHEA-LDSLTYTREEIERIVHVAFKLA 173 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 SR R LTS K N LA S W + V +++ YPE+ + +D + P++FD Sbjct: 174 ASR-RGKLTSVDKENVLA-SSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFD 231 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V NLFGDILSD G++G++PSA+ + + P L+EP+HGSAPDI GKN+ANP Sbjct: 232 VIVYENLFGDILSDEASVIPGSLGLSPSASFSNDG--PRLYEPIHGSAPDIAGKNVANPF 289 Query: 299 ATIWAGAMMLDFLGN----GDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 I + AM L N DE Q +N +I HG T D+ G T + + Sbjct: 290 GMILSLAMCLRESLNQPDAADELEQHIYN--------MIEHGQTTADLGGKLNTTDIFEI 341 Query: 355 ICK 357 + + Sbjct: 342 LSQ 344 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 187 bits (474), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 110/355 (30%), Positives = 181/355 (50%), Gaps = 30/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 I+ + GDGIG E+ + +L+A + + +L +++E A + GK +PD+ E Sbjct: 6 NISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLE-AGDAVLKNTGKALPDETFEA 64 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA VG S ++ RR D Y N+RP + +P +P Sbjct: 65 IKNSDACLKAPVGE--------SAKDVIVYLRRMLDLYANIRPAKSYPNMPS-----LRD 111 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEV---VIQESVFTRRGVDRILRYAFELAQSRP 182 D+D +VRENTE Y+ G E ++ + + + + RI YAF +A R Sbjct: 112 DVDLVIVRENTEDLYT--------GEEFDIGDAAVAFRIISEKASKRIANYAFTIASKRK 163 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K +T KSN + + + +A ++P++++++ ++D + QP+ FDV+V Sbjct: 164 MKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQLFDVIVT 223 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NLFGDILSD G +G+AP+AN+ LFEPVHG+A DI GK IANP + I Sbjct: 224 TNLFGDILSDESAQVVGGLGMAPAANIGDNF---GLFEPVHGAAFDIAGKQIANPTSFIL 280 Query: 303 AGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 + MMLD+LGN D++ + + + +++ + KT D+ G+ TT + I Sbjct: 281 SIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGDKTTMEFTKEI 335 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 185 bits (470), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 132/370 (35%), Positives = 185/370 (50%), Gaps = 29/370 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA + GDGIG EV+ E +VL A ++ F ++ + + +HG +PD Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGGAAI-DNHGNALPDSTMAG 61 Query: 66 LSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI FG+VG W + P +LL R FD + N+RP L P + + Sbjct: 62 CIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLR 121 Query: 123 QPGDI-----DFYVVRENTEGEY-SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 DI D V+RE T Y GR EG E E ++RR V RI AF+ Sbjct: 122 S--DISEQGFDVLVIRELTGDIYFGEPKGRRGEG-EEETGFDSMFYSRREVKRISHLAFQ 178 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 AQ R K +TS K+N LA S W + VE +A YP++ + ++D + V P + Sbjct: 179 AAQKRNNK-VTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQ 236 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV++ NLFGDILSD+ TG++G+ PSA+LN + ++EP GSAPDI G +AN Sbjct: 237 FDVMLCPNLFGDILSDICAMITGSMGLLPSASLNSDGF--GMYEPAGGSAPDIAGLGVAN 294 Query: 297 PIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTP 349 PIA I + A+ML + L G A I A+ + +G T D+ K +T Sbjct: 295 PIAQILSAALMLRYSLNQG-----AAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTS 349 Query: 350 QVADAICKII 359 +V D ICK I Sbjct: 350 EVGDYICKQI 359 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 184 bits (467), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 132/351 (37%), Positives = 178/351 (50%), Gaps = 17/351 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + R+ +PGDGIG EV+ RV AAA R+G L +E+ + G + Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRIGAA-AIREEGAPVSK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + + DA+ GAVG P+ + LL RRE + NLRPV P + P Sbjct: 60 ETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D +VRE T G Y G EG E + SV+TR V+R+ R AFE A Sbjct: 120 LRPGVAEGVDLLIVRELTGGAYF---GEKEEGEERASDL--SVYTRGEVERVARVAFEAA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R + S K+N LA S W V +A +YP++ + +D V P RFD Sbjct: 175 RGR-RGRVASVDKANVLATSR-LWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRFD 232 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ NLFGDILSD G++G+ PSA+L E P +FEPVHGSAPDI GK +ANP Sbjct: 233 VILTENLFGDILSDEAAVLPGSMGMLPSASLG-EPGSPGIFEPVHGSAPDIAGKGVANPY 291 Query: 299 ATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 A I + AMM LG +A I +E +A G TPD+ G++ T Sbjct: 292 AAILSAAMMFRHGLGR-----PEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 182 bits (461), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 132/351 (37%), Positives = 178/351 (50%), Gaps = 37/351 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+A IPGDGIG EV+ +RVL+A R + FE E + + G + ++ E+ Sbjct: 3 RVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYE-GGVDVFQECGSPIREEDLEE 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R DA+ FGA P +P + SL +L R+E Y NLR + P G++ Sbjct: 58 IRRSDAVLFGATTTPFDLPGYRSL---ILTLRKELGLYANLRII------PDLRTGRE-- 106 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +VREN+EG Y +G VN G +V + TR G +RI R+A E A++R Sbjct: 107 ---IVIVRENSEGLYFGIGAVVN-GRAVDV----RLITREGAERIARFAVEQAKARG-SF 157 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K+N L + E E E+R ID + V P V+++ NL Sbjct: 158 ITFVHKANVLTGDKFFRRIVREVAGEEGVEVR--DAIIDSFTIKLVRNPWEHGVILSENL 215 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSDL G+IGI PS N +LFEPVHGSAPDI GK IANPI I +GA Sbjct: 216 FGDILSDLATVHAGSIGIVPSGNYGDG---IALFEPVHGSAPDIAGKGIANPIGAILSGA 272 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 M+LD+LG + I AA+ + +G TPDM G A T V I Sbjct: 273 MLLDYLG-------LDGSLIRAAVRGYVVNGELTPDMGGRARTEDVVRGII 316 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 181 bits (459), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 112/344 (32%), Positives = 175/344 (50%), Gaps = 19/344 (5%) Query: 1 MMKTMR--IAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKM 57 M + +R IA +PGDGIG E++ + VL+ ER G F +E + +Y G Sbjct: 1 MKRDLRFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAA-HYQKTGTA 59 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 D+ + DA+ GA+G P + + L R E D Y LRP+R +P +P Sbjct: 60 FSDENMAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPR 119 Query: 118 PLAGKQPGDIDFYVVRENTEG-EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L K+ ID +VRE TEG YS G + + V + + +R G R+ +AF Sbjct: 120 VLVDKRASQIDLVLVREQTEGILYSRCRGTIED---DRVAWETMMISRNGTSRVSEFAFR 176 Query: 177 LAQSRPRK-----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 +A+ R + + +SN L SM ++ +AE +P + D ++D + V Sbjct: 177 VAERRAKSRRRPGKVLCVDRSNALT-SMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLV 235 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 P FDV+V N FG ILSDL G++G+APSA++ + ++F+P HGSAP I G Sbjct: 236 KSPWEFDVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEKH---AVFQPAHGSAPHIAG 292 Query: 292 KNIANPIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVI 333 + +ANP+A I + A+MLD+L + G+ R + A+E+ + Sbjct: 293 QGLANPVAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKAL 336 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 180 bits (457), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 110/325 (33%), Positives = 169/325 (52%), Gaps = 19/325 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ R+++A G + +E + + +PDD E + Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + G P P + + R+ F+ + N+RPVR P VP P G+ + Sbjct: 79 KRTRVVLKG----PLETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRGR---N 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+++ R G V I + + +G ++I+R+AFELA++ RK + Sbjct: 132 IDLVVVRENIEDLYAAIEYRETPG----VTIAHKLISYKGSEKIIRFAFELARAEGRKKV 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T ATKSN L ++ ++ E +A YP+I + ID + V PE+F+V+V +NL Sbjct: 188 TCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLN 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDI+SDL G +G A S N E ++FEPVHG+AP GKN+ NP A I M Sbjct: 248 GDIISDLASGLVGGLGFAASGNYGHE---VAIFEPVHGTAPKYAGKNVINPTAMILTAVM 304 Query: 307 MLDFLGNGDERFQQAHNGILAAIEE 331 ML ++ + E + ++ +EE Sbjct: 305 MLRYI-DEFETAETIEQALIVTLEE 328 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 120/360 (33%), Positives = 193/360 (53%), Gaps = 12/360 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M ++ + + GDGIG EV + +R+L+ G ++ EY G+ +P Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEY-QRSGEALP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ DA+ GA+G P+ + L R Y +RP+RL+ PL Sbjct: 60 QSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPL 119 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G PG+IDF +VRE+TEG + G E + TR +R+ R AFE A+ Sbjct: 120 KGHGPGEIDFVLVRESTEGLF--YGRDAIADLEADEATNLLRITRSASERVCRLAFETAR 177 Query: 180 SRP-RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +KT+T K+N L+ SM Y+ + +A+ + +I+ + ++D V +P+ FD Sbjct: 178 RRDGKKTVTLIDKANVLS-SMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFD 236 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APS ++ + ++F+P HGSAPDI G++IANPI Sbjct: 237 VMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDD---AAVFQPSHGSAPDIAGQSIANPI 293 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICK 357 A + AMML++L + + R +A + + AAI +V++ +T DM GN +T ++ D I + Sbjct: 294 AMHLSTAMMLEWLDHPETR--RAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAE 351 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 179 bits (453), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 117/371 (31%), Positives = 179/371 (48%), Gaps = 25/371 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IA IP DG+GK+V+P G + +Q A E GF L E A EY GKM D Sbjct: 1 MKKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE-AGVEYAVKTGKMCED 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT------VPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + E +++ DA+ G+ G D P + + L R + LRP+RL G Sbjct: 60 NLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + CPL ++ +ID +VR+ EG Y G + E ++ + V TR ++ Sbjct: 120 IDCPLRNRE--EIDVLLVRQLAEGFYIRPGHMIGEDAAYDTI----VVTRNVTEKFADTC 173 Query: 175 FELAQSR-----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 F LA+ R K + + +G ++ + ++ YP+I +D L Sbjct: 174 FRLARGRHGRRQDGKKMVTLGNKHGNVTCFDFYRKIFTEVSAGYPDIGLQFTQVDALAEH 233 Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 + P+RFDV+ N+ GDI+ D+G TG +GI P+A++ F P HG+ P Sbjct: 234 LIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVGG---VTPQFRPNHGTFPRA 290 Query: 290 YGKNIANPIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIE-EVIAHGPKTPDMKGNA 346 GK ANP+A+I ++LD LGN GD+ ++ I A+E + GP+T D+ G A Sbjct: 291 VGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGGTA 350 Query: 347 TTPQVADAICK 357 T A+A+ K Sbjct: 351 NTFATAEAVFK 361 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 178 bits (452), Expect = 2e-43, Method: Compositional matrix adjust. Identities = 123/352 (34%), Positives = 182/352 (51%), Gaps = 30/352 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 I I GDGIG+EV+P + VLQA E GF+ + +Q A + G +P+ +E Sbjct: 8 EIVVIEGDGIGQEVIPAAVAVLQAVDE-VGFSFTEKQ---AGDDTRDQTGAALPETTYEA 63 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA FGA G +T D I L R +VN+RP R +PGV QP Sbjct: 64 AADADATLFGAAG--ETAADVI------LPLREAVGSFVNIRPARAYPGVDA----LQP- 110 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 + D +RENTEG YS R++E ++ V T +++ YA R Sbjct: 111 ETDLVFLRENTEGVYSGHEDRLSE----DLSTLTRVITTSASEQLAEYACSYVTERSIDG 166 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N + + + + V +A + ++ ++ +D R + P +FDVVV NL Sbjct: 167 FHTVHKANVMQETDGRFRDAVSRVAASN-DVATNEVLMDAFATRVCLNPTQFDVVVCPNL 225 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 GD+LSDL G +G+ PSAN+ +LFEPVHG+APDI G IANP A+I + Sbjct: 226 AGDVLSDLAAGLVGGLGLLPSANIGQTN---ALFEPVHGTAPDIAGDGIANPSASILSAG 282 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 M+L++LG D A + A+E V+ GP+TPD+ GNA+T V +A+ + Sbjct: 283 MLLEYLGETD-----AATNVQMAVESVLNSGPRTPDLGGNASTEAVVNAVIE 329 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 178 bits (452), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 117/332 (35%), Positives = 171/332 (51%), Gaps = 33/332 (9%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG E + ++VL+AA L++E E + + +P + E + Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + G P P + + R+ F+ Y N+RPVR FP VP P AG+ Sbjct: 78 RKTRVVLKG----PLETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAGR---G 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEH----EVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID VVREN E Y+ G EH V + + +G ++I+R+AFELA++ Sbjct: 131 IDLVVVRENVEDLYA--------GIEHMQTPSVAQTLKLISWKGSEKIVRFAFELARAEG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK + ATKSN + ++ E +A+ YP+I +D + V +PE+F+V+V Sbjct: 183 RKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVT 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +N+ GDILSDL G +G APSAN+ E ++FE VHGSAP GKN+ NP A + Sbjct: 243 TNMNGDILSDLTSGLIGGLGFAPSANIGNE---VAIFEAVHGSAPKYAGKNVINPTAVLL 299 Query: 303 AGAMMLDFLGNGDERFQQA---HNGILAAIEE 331 + MML +L E F A N +L +EE Sbjct: 300 SAVMMLRYL----EEFATADLIENALLYTLEE 327 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 174 bits (441), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 115/371 (30%), Positives = 186/371 (50%), Gaps = 28/371 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC----EYYSHHGKMM 58 K +A + GDGIG E++P +++L AA A + W +G+ Sbjct: 22 KQYSLAVLHGDGIGPEIVPASVKILDAAVA----AAGATPIAWTELPLGRSAIDEYGEHT 77 Query: 59 PDDWHEQLSRFDAIYFG---AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 P + L D G + +P+ ++ G++ R+ F + N+RP + F G Sbjct: 78 PTKTLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTI---RKHFGLFANIRPAKAFRGG 134 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYS---SLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 + G D +VRENTEG Y+ + G +V I + TR +RI Sbjct: 135 NAIVEGT-----DLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAH 189 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 AF+LA++R ++ +T K+N L ++ + + + + YP++ + HID V Sbjct: 190 EAFQLARTRDKR-VTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVR 248 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 + ++FDV+V N+FGDILSDL G++GIAPS N + ++ + HGSAPDI G+ Sbjct: 249 RADKFDVIVTENMFGDILSDLAGEVAGSLGIAPSINSSATH---AMAQASHGSAPDIAGR 305 Query: 293 NIANPIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 +IANPIA I + AM+L +L DE+ +A + + AA++ +A G TPDM G ++ Sbjct: 306 DIANPIAMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDMGGTSSCSG 365 Query: 351 VADAICKIILR 361 ADA+ R Sbjct: 366 FADAVVAATAR 376 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 172 bits (436), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 109/325 (33%), Positives = 173/325 (53%), Gaps = 42/325 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A IPGDGIG+E++P G+ ++ F ++F+ S E Y G ++ DD E+L Sbjct: 4 VALIPGDGIGREIMP-GVAAAISSISDINF-VTFD----ISSERYIKTGIIIKDDELEEL 57 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + AI FGA+G P P I G +L+ RRE + Y+N+RPVR F Sbjct: 58 KNYRAILFGAIGDPRVRP-GIMEQGVILRLRRELELYMNIRPVRSFDD-----------K 105 Query: 127 IDFYVVRENTEGEYSSLGG---------------RVNEGTEHEVVIQESVFTRRGVDRIL 171 I ++RENT+ Y+ + G ++ + EV + + R + + Sbjct: 106 IKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFF 165 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 AF + S T+T K+N + + + +EA E I + ++ D L + Sbjct: 166 NKAFSICDS----TVTVTDKANAVKMYNLWRSTAMEAAIEKNINISF--EYADALAYNMI 219 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + P+++ ++A NL+GDI+SD+G A G +G APSAN+ + +LFEPVHGSAPDI G Sbjct: 220 LNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDKN---ALFEPVHGSAPDIAG 276 Query: 292 KNIANPIATIWAGAMMLDFLGNGDE 316 +++ANP A+I AG+M+L++LG DE Sbjct: 277 RDMANPAASIMAGSMLLEYLGYRDE 301 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 171 bits (433), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 106/314 (33%), Positives = 162/314 (51%), Gaps = 27/314 (8%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM-MPDDWHEQLSRFDAIYFGAVG 78 + EG++VL A +E G + E + +YY G + P D ++ D I GAVG Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGG-QYYLEQGDLDWPSDAPQKCDAADLILLGAVG 59 Query: 79 WPDTV---------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK-----QP 124 WPD + ++ + ++ R + Y N+RP++L+PGV + G + Sbjct: 60 WPDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEA 119 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 G +D ++RENTEG Y+ GG++ G + +V I V TRR ++++R+AFEL + R + Sbjct: 120 GKVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKG 179 Query: 185 T-------LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 +T+ K N L + D E AE YPEI D +D V QPE + Sbjct: 180 APKDGKLRVTAIIKDNVLHGCQLFRDVFFEIGAE-YPEIEKDTAIVDAFTQWLVGQPEYY 238 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV V SN+FGDI++DL G +G+A N+ ++FEP+HGSAP GK+ NP Sbjct: 239 DVCVTSNMFGDIVTDLASTLQGGMGMAVGGNIGKHN---AMFEPIHGSAPKHAGKDKVNP 295 Query: 298 IATIWAGAMMLDFL 311 IA I + L++L Sbjct: 296 IAMILSVKEGLEWL 309 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 170 bits (431), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 126/356 (35%), Positives = 171/356 (48%), Gaps = 21/356 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI + GDG+G EV+ VL +G Q E+ G+ +P Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHL-QDEYFGGVAIDLTGQPLPQRTLAA 62 Query: 66 LSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 DA+ GAVG P D+ + LL R+ + N+RPV + K Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPE--KGLLALRKGLGVFANVRPVTVESATAHLSPLKN 120 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +IDF VVRE T G Y S E TE EV + R ++RI+ YAF+LA R + Sbjct: 121 ADEIDFVVVRELTGGIYFSYP---KERTE-EVATDTLTYHRHEIERIVSYAFQLANKRKK 176 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +TS K+N L S W E +A YP + + +D + P RFDV+V Sbjct: 177 K-VTSIDKANVLE-SSKLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTE 234 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLFGDILSD G++G+ PSA+ + E+ PSL+EP+HGSAPDI GKN ANPIA + + Sbjct: 235 NLFGDILSDEASVLAGSLGMLPSAS-HAEKG-PSLYEPIHGSAPDIAGKNKANPIAMMRS 292 Query: 304 GAMMLDFLGNGDERFQQAHNG--ILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 AMML + F G I A+ V+ G T D+ G TT A+ + Sbjct: 293 VAMML------GQSFGLTREGYAIEEAVSAVLKSGKCTADIGGTETTTSFTKAVIQ 342 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 170 bits (431), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 116/358 (32%), Positives = 180/358 (50%), Gaps = 31/358 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW--ASCEYYSHHGKMMPDD 61 + +I A+PGDGIG E+L + +L+ +E++ F E + S +YY G + ++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYY---GTPLTNE 58 Query: 62 WHEQLSRFDAIYFGAVG---W--PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 + DAI GA+G W P+ P+H LLK R+ + + N+RP + G Sbjct: 59 TLQSCKNADAILLGAIGGPKWTDPNNRPEH-----GLLKLRKSLNLFANIRPTFVTKGAS 113 Query: 117 --CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL D +VRE T G Y V + TE + ++ + ++RI+R A Sbjct: 114 HLSPLKQDIVEGTDLVIVRELTSGIYFGEPSYVKK-TE---ALDSLKYSSQEIERIVRIA 169 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F LA R RK LTS K N L+ S W + V + ++YPE+ + +D + QP Sbjct: 170 FNLANRR-RKKLTSVDKENVLS-SSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQP 227 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 +FDV+V NLFGDILSD G++G++PSA+ +T L+EP+HGSAPDI ++ Sbjct: 228 TQFDVIVTENLFGDILSDEASVIPGSLGLSPSASFG--QTGTRLYEPIHGSAPDIANEDK 285 Query: 295 ANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 ANP + + A+ L + L D A N + + + I T D+ G T ++ Sbjct: 286 ANPFGMVLSLALCLRESLNQND-----AANELESIVYSFIQSNKTTADLGGQYRTSEI 338 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 170 bits (430), Expect = 9e-41, Method: Compositional matrix adjust. Identities = 125/358 (34%), Positives = 181/358 (50%), Gaps = 39/358 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RIA IPGDG+G E++ I VL+ ++ L E A E G +P++ Sbjct: 3 RIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFE-AGDETKRKRGVALPEETLNG 61 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA A+G S +L R++ D YVNLRP + +P VP + G Sbjct: 62 VMNSDATLMVAIGE--------SAREVILPLRQKLDLYVNLRPAKSYP-VPRAIPG---- 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D +VRENTE Y G R G + V ++ + TRR +RI R+ + A+ R + Sbjct: 109 -FDLTIVRENTEDLYVMSGWR---GLDTAVDLR--IITRRASERICRFGYRYARERGKSR 162 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N L M + E +AE + + ++D R M FDV++ +N+ Sbjct: 163 VYVVHKANVLGGCM-LFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVIITTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSDL A G +G+ PSAN+ R ++FEPVHG+AP+I GKNIANP+ATI + A Sbjct: 220 FGDILSDLAAAFIGGLGMYPSANIGESR---AIFEPVHGTAPEIAGKNIANPMATILSAA 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH----GPKTPDMKGNATTPQVADAICKII 359 MM+ +LG H G IEE + G TPD+ G+ T +V I +I+ Sbjct: 277 MMMGWLG---------HEGGSKLIEEAVRRACELGYTTPDVGGSMRTKEVGLKISEIM 325 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 168 bits (426), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 111/307 (36%), Positives = 155/307 (50%), Gaps = 20/307 (6%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + RI AIPG+GIG EV+ +++LQ A+ GF L + W + G P Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVD-YGWLGATAFEQLGSYFPQATT 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLAG 121 E D I FGAV G LL+ R+ FD + NLRP+R + L Sbjct: 67 ELCDGADGIVFGAVSQ-----------GGLLELRKHFDFFCNLRPIRSVNSLLHKSSLRP 115 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++ +D +VRE G Y GR ++ + + RI R A E AQ R Sbjct: 116 EKIQGLDILIVRELVSGIYFGPSGRSSD-ERGNYGYHTMRYYDEEIRRIARKALEQAQYR 174 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LT A K N A+ +W V+ A +P + + +D L + V+ P+RFDV++ Sbjct: 175 -RGLLTVAHKEN--ALPHLHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVIL 231 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDILSD+G A G+IG+ SA+LN L+E +HG+APDI G IANP+ T+ Sbjct: 232 ASNLFGDILSDIGGALVGSIGLLGSASLNANGF--GLYEAIHGTAPDIAGLGIANPLGTL 289 Query: 302 WAGAMML 308 A +ML Sbjct: 290 GACVLML 296 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 168 bits (426), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 122/370 (32%), Positives = 186/370 (50%), Gaps = 21/370 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M IA +PGDGIG E + ++L +++ + + + + + G P Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGG-DAINSEGTPFPK 59 Query: 61 DWHEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 + + +AI FGAVG W G+LL R+ F+ + NLRP+ L + Sbjct: 60 STLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKE 119 Query: 117 -CPLAGKQ-PGDIDFYVVRENTEGEY-SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 PL P ID VRE T G Y GR G +E +V+ R ++RI Sbjct: 120 LSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGL-NEYAFDTAVYHRFEIERIANI 178 Query: 174 AFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 AF+LAQ R RK ++S K+N L SM W E V +A+NYP++ + +ID + + Sbjct: 179 AFKLAQKR-RKRVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNASMQLINN 236 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 P +FD+++ NLFGDILSD +G+IG+ PSA++N E F L+EP GSAPDI KN Sbjct: 237 PSKFDIILCPNLFGDILSDECAMISGSIGMLPSASIN-EHNF-GLYEPAGGSAPDIAEKN 294 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 IANPIA I + A++ + + I A+ + + G +T D+ + + +T Sbjct: 295 IANPIAHILSIALLFRY----SLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTN 350 Query: 350 QVADAICKII 359 ++ D I +I Sbjct: 351 EMGDIIAALI 360 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 166 bits (421), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 113/358 (31%), Positives = 174/358 (48%), Gaps = 38/358 (10%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAA------ERWGFALSFEQMEWASCEYYSHHGKMMPD 60 + IPGDGIG E+ +++ AA ER A+ +W M+P Sbjct: 34 VTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKW-----------MIPS 82 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + + G + P H S+ L R+ FD Y N+RP G P Sbjct: 83 EAKESMDKNKMGLKGPLKTP-IAAGHPSMN---LLLRKTFDLYANVRPCVSIEGYKTPYT 138 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D++ +RENTEGEYS + + +G VV + T RI +AFE A++ Sbjct: 139 -----DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLITEGASKRIAEFAFEYARN 189 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R +T+ K+N + +S + ++ +AE+ +I++++ ++D +C V P +FDV+ Sbjct: 190 NHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVL 249 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI GK++ANP A Sbjct: 250 VMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGV--AIFESVHGTAPDIAGKDMANPTAL 307 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICK 357 + + MML +G D + I AA I G T D+ GNA + IC+ Sbjct: 308 LLSAVMMLRHMGLFDHAAR-----IEAACFATIKDGKSLTKDLGGNAKCSDFTEEICR 360 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 166 bits (421), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 115/360 (31%), Positives = 176/360 (48%), Gaps = 36/360 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K ++ IPGDGIG E+ RV A +EW + ++ G + + Sbjct: 22 KIQKVTLIPGDGIGPEISESVKRVFSAVKA---------PIEWETVVVDANTG--ISKEV 70 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E +S+ G + P H SL L R+ F+ Y N+RP PG Sbjct: 71 IESISKNKIGLKGPISTPIGT-GHQSLN---LGLRKTFNLYANIRPCLSIPG-----HKT 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + +++ VVRENTEGEYS + + +G + + T+ RI YAF+ A + Sbjct: 122 RYNNVNTVVVRENTEGEYSGIENQPVKGVAQSI----KIITKEASTRIAHYAFQYALANG 177 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T K+N + S + + ++ YP I++++ ID C + V+ P + DV+V Sbjct: 178 RKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQMDVMVL 237 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDI+SDL G +G+ PS N+ + ++FE VHG+APDI GKN ANP A I Sbjct: 238 PNLYGDIVSDLCAGLIGGLGLTPSGNIGENGS--AIFEAVHGTAPDIAGKNKANPTALIL 295 Query: 303 AGAMMLDFLGNGDERFQQA---HNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + MML LG+ F +A N +L + E KT D+ GN++ + D + K I Sbjct: 296 SSIMMLRHLGH----FHEASIIENAVLNTLTE---GKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 118/373 (31%), Positives = 189/373 (50%), Gaps = 55/373 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIGKE++P+ ++ + F +F + S E Y + G + D ++L Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNF--TFYNI---SSERYINKGITIKDSEIDEL 58 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +++I+FGA+G P I G +L+ R+E D Y+N+RP F + + Sbjct: 59 KSYNSIFFGAIGDFRVKPG-IMEQGVILRLRKELDLYMNIRPAISFSRI-------TGNN 110 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVF----------------------TR 164 I ++REN E YS + G +NE H++ Q+ F +R Sbjct: 111 IHMTILRENKEDFYSDISGSLNE---HKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSR 167 Query: 165 RGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHI 223 + + R A+++A + +T+T K+N + + W E A+ E+ P + + ++ Sbjct: 168 KNLKRFFNMAYKIADT---ETVTITDKANAVDM-YSLWREI--AIEESEPAGKKINFEYA 221 Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D L + P ++ ++A NL+GDILSD+ A G +G APS N+ + S+FEPVH Sbjct: 222 DSLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD---YSSMFEPVH 278 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGIL-AAIEEVIAHGPKTPDM 342 GSAPDI GKNIANP+A+I + MML L Q GI+ ++E VI +G + Sbjct: 279 GSAPDIAGKNIANPVASILSCIMMLKHLN------QTETAGIMEKSVENVIRNGTIPIES 332 Query: 343 KGNATTPQVADAI 355 GNA T + + + Sbjct: 333 GGNAGTHEFINKV 345 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 107/314 (34%), Positives = 166/314 (52%), Gaps = 20/314 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC--EYYSHHGKMMPDDW 62 +IA + GDGIG E+ +G+ V+ A E++G +++E +A C + G P++ Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYE---YAICGADAIDKVGDPFPEET 59 Query: 63 HEQLSRFDAIYFGAVGWPDTVPD---HISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ F AVG P D + LL R++ + N+RPV+ F + Sbjct: 60 YRVCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PL + DF +RE T G Y G + + ++ +++TR ++RIL+ FE Sbjct: 120 PLRAELVEGADFLCIRELTGGMY--FGEKYQD---NDKAYDTNMYTRPEIERILKVGFEY 174 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A R RK LT K+N LA S W + + MA YPE+ D +D + + +P+ F Sbjct: 175 AMKR-RKHLTVVDKANVLA-SSRLWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFF 232 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V N FGDIL+D G +G++G+ PSA+ E T +FEP+HGS P G NIANP Sbjct: 233 DVMVTENTFGDILTDEGSVISGSMGLLPSASTG-EST--PVFEPIHGSWPQAKGLNIANP 289 Query: 298 IATIWAGAMMLDFL 311 +A I + AM+ ++ Sbjct: 290 LAQILSVAMLFEYF 303 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 164 bits (415), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 117/362 (32%), Positives = 175/362 (48%), Gaps = 19/362 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFA--LSFEQMEWASCEYYSHHGKMMP 59 M ++ + GDGIG E+ + VLQAA + + L +E++ +AS + H Sbjct: 1 MSNLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEIGFASLK---KHKTTFR 57 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + + + D + G D P R+ FD Y N+RP + G Sbjct: 58 SEVLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGK---- 113 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFE 176 + P ID V+RENTEG YS G +V I TR+G RI F+ Sbjct: 114 LERFPMGIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAEIGFK 173 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 A R RK L + K+N L S + E +++ YPE+ + +Q +D + A + P Sbjct: 174 YAMER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRDPSV 232 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV++A+NLFGD LSD G +G+A S N + HGSAPDI GKNIAN Sbjct: 233 FDVILATNLFGDNLSDAASEIAGGLGLAESINAGENYCIA---QAQHGSAPDIAGKNIAN 289 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVAD 353 P++ I + AMMLD+LG N +++ ++ I AI++ I + +T D+ GN +T D Sbjct: 290 PVSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDIGGNLSTTDFTD 349 Query: 354 AI 355 + Sbjct: 350 VL 351 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 164 bits (414), Expect = 6e-39, Method: Compositional matrix adjust. Identities = 123/371 (33%), Positives = 188/371 (50%), Gaps = 27/371 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ +PGDGIG E + E +V+ E+ C Y HG+ + D Sbjct: 1 MASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAY-DAHGQAISDA 59 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 E+ D++ FGAVG P D+VP + LL+ R++ Y NLRP +P + Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AENYPEIRWDKQHIDILCARFVMQPE 235 LA++R R +TS K N + S W++ V A E + +++ + D + V P+ Sbjct: 180 LARTR-RNKVTSMEKRNVMK-SGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPK 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERT----FPSLFEPVHGSAPDIYG 291 +FDV++ NLFGD+LSD+ TG++G+ PSA+L + +L+EPVHGSAPDI G Sbjct: 238 QFDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDF---LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGNA 346 K IANPIA I + AM L + L +R + AAI V+ G +T D+ +GN Sbjct: 298 KGIANPIAMIASLAMCLRYSFGLVAEADRLE-------AAIAGVLDDGIRTADIWSEGNT 350 Query: 347 T--TPQVADAI 355 T ++ DAI Sbjct: 351 KVGTTEMGDAI 361 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 163 bits (413), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 111/360 (30%), Positives = 179/360 (49%), Gaps = 18/360 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF-ALSFEQMEWASCEYYSHHGKMMPDDWH 63 M+IA I GDGIG +V I VL+ A + G A +++++ A Y+ G + D Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQ-AGAGYFKETGLDIEDGGE 59 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E+ DAI+ GA+G P + + L+ R F Y +RPV+ +P P LA + Sbjct: 60 ERAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPR 119 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESV-FTRRGVDRILRYAFELAQSRP 182 ID ++RE+TEG + S ++ +Q+ + TR+ ++ R+AF LA+ R Sbjct: 120 AAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRR 179 Query: 183 RK----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + LT K+N + S+ ++ + + + + ++ ++D V +P FD Sbjct: 180 ERGHPGRLTCVDKAN-VFTSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFD 238 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+A + LF+P HGSAPDI G++ ANP+ Sbjct: 239 VLVMENMFGDILSDLAGGLVGGMGMAACGEIGDT---TGLFQPAHGSAPDIMGEDKANPL 295 Query: 299 ATIWAGAMMLDFLGNGDER--FQQAHNGILAAIEEVIAHGPKTP-----DMKGNATTPQV 351 A I + A+MLD+L ++ A I +A+E H P DM A T ++ Sbjct: 296 AAILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKEL 355 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 163 bits (412), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 106/325 (32%), Positives = 159/325 (48%), Gaps = 37/325 (11%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ IPGDGIG PE R + E G L + ++E A E +G +P E Sbjct: 4 RVTLIPGDGIG----PEVTRAMTTVLEASGVDLEWIRVE-AGVEVIEKYGTPLPPQVLES 58 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + G +G P + R+E D Y NLRP + PG+ P Sbjct: 59 IRETRVAIKGPIG----TPVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQ----- 109 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGT------EHEVVIQESVFTRRGV------------ 167 DID VVRENTE Y+ + GT E++ F R G Sbjct: 110 DIDLVVVRENTEDLYAGI--EFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGS 167 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI+++AFE A+ RK +T+ K+N + + + + +A+ YP+I ++ +D +C Sbjct: 168 RRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMC 227 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + + +P+ +DV+V +NL+GDI+SDL G +G+AP AN+ ++FE +HGSAP Sbjct: 228 LQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIG---DGIAVFEAIHGSAP 284 Query: 288 DIYGKNIANPIATIWAGAMMLDFLG 312 G+N NP A I +GAMML +LG Sbjct: 285 KYAGQNKVNPSALILSGAMMLRYLG 309 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 162 bits (411), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 105/314 (33%), Positives = 166/314 (52%), Gaps = 17/314 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I +PGDGIG E++ +RVL+AA++R+ L + A HG + E Sbjct: 1 MKIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIGH-DIAGHASLQRHGATVTPALLE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D + G + D + FR+E D Y N+RP R FPG+ + Sbjct: 60 KVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGM-----AHRV 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVF-----TRRGVDRILRYAFELAQ 179 G+ + VVRENTEG Y+ + G+ ++ ++V TR +RI R AF+LA+ Sbjct: 115 GEFNLAVVRENTEGFYADRN--IESGSSEMLITPDTVISLRRITRLCCERIARSAFDLAR 172 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 +R R ++ K+N L I + + +A +P++R D +D + A V P+RFDV Sbjct: 173 TRARH-VSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFDV 231 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V +N+FGDILSDL +G++G+ S N + ++ + VHGSAPDI G+NIANP + Sbjct: 232 IVTTNMFGDILSDLTAELSGSLGLGGSLNAGKDH---AMGQAVHGSAPDIAGRNIANPYS 288 Query: 300 TIWAGAMMLDFLGN 313 I + +L + G Sbjct: 289 LILSAGQLLGWHGQ 302 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 162 bits (410), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 128/384 (33%), Positives = 188/384 (48%), Gaps = 38/384 (9%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVL---QAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M T +I +PGD IG E++ E I+VL + F L+ + + S + HG Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDT---HGVP 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 + + DA+ FG++G P+ H + LL+ R+ D + NLRP VP Sbjct: 58 ITQSVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFL--VPS 115 Query: 118 PLAGKQP------GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQES-VFTRRGVDRI 170 L G P F VVREN G Y E E E V + V+TR ++R+ Sbjct: 116 -LVGASPIREHVVKGTRFIVVRENCGGAY------FGEKKEEEDVASDLWVYTRPEIERL 168 Query: 171 LRYAFELAQSRPRK-------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHI 223 R + +A+ R T+ SA K+N LA + + A+ +P+I Q Sbjct: 169 ARVSAAVARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLA 228 Query: 224 DILCARFVMQPERFDVVVAS-NLFGDILSDLGPACTGTIGIAPSANLN--PERTFPS--L 278 D + V P RF+ V+ + N FGDILSD+ A TGT+G+ PSA+L P S + Sbjct: 229 DSMAMLMVRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGI 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 +EPVHGSAPDI GK +ANP+A I + AMML + G E+ A + + + + G Sbjct: 289 YEPVHGSAPDISGKGLANPVAQILSVAMMLRY-SMGLEKEATAVERAVVKVLDAKSEGGL 347 Query: 338 --KTPDMKGNATTPQVADAICKII 359 +T D+ G AT QV DA+C+++ Sbjct: 348 EIRTGDLGGRATCSQVGDAVCEVL 371 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 162 bits (409), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 114/359 (31%), Positives = 174/359 (48%), Gaps = 37/359 (10%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY---SHHGKM-MPDDW 62 +A IPGDGIG E+ +AA + F + ++W S + + G+ MP Sbjct: 1979 VALIPGDGIGPEI---------SAAVQEIFKFADVPIKWESVDVTPRPTEDGRFRMPQ-- 2027 Query: 63 HEQLSRFDAIYFGAVGW--PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 S D I +G P P L R+EF+ Y N+RP + G P Sbjct: 2028 ----SSLDIIRKHGIGLKGPLATPIGKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYK 2083 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++D VRENTEGEYS + + +G VV + T R+ R+AF+ A+ Sbjct: 2084 -----NVDLVTVRENTEGEYSGIEHVIVDG----VVQSIKLITEEASRRVARFAFQYAKD 2134 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R+++T+ K+N + +S + A ++ EI + +D +C V P RFDV+ Sbjct: 2135 NGRRSVTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVL 2194 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI G++ ANP A Sbjct: 2195 VMPNLYGDILSDLAAGLIGGLGVTPSGNIGET---GAIFESVHGTAPDIAGQDRANPTAL 2251 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +++ MML ++ N ++ + +LA I E T D+ G +T Q IC+ I Sbjct: 2252 LFSAIMMLRYM-NLNKHADLIESAVLATIREA---KYLTADLGGRSTCSQYTKEICRQI 2306 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 162 bits (409), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 108/331 (32%), Positives = 163/331 (49%), Gaps = 24/331 (7%) Query: 12 GDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDA 71 GDGIG E++ + VL+ AA L E +E Y ++ + +D Q+ R A Sbjct: 12 GDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITEDTWSQIFRTKA 67 Query: 72 IYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYV 131 + G P T P + R+ Y N+RP + P +ID + Sbjct: 68 LLKG----PVTTPQGGGYKSLNVTLRKTLGLYANVRPSCSY----FPFVNTSAPEIDVVI 119 Query: 132 VRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATK 191 +REN E Y+ + T V + +R G ++I+R+AFE A RKT++ +K Sbjct: 120 IRENEEDLYAGIEYHHTADTYESV----KLISRSGSEKIIRFAFEYALKNNRKTISCFSK 175 Query: 192 SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILS 251 N + + + + +A Y I+ D IDI AR + P++FDV+V SNL+GDILS Sbjct: 176 DNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVIVTSNLYGDILS 235 Query: 252 DLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFL 311 D+ +G+IG+A SAN+ + ++FE VHGSAPDI G+NIANP + A MML L Sbjct: 236 DIAAKISGSIGLAGSANIGKDY---AMFEAVHGSAPDIAGQNIANPSGLLNAAIMMLVHL 292 Query: 312 GNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 G + I A+++ I G T D+ Sbjct: 293 G-----LTEHAAKIENALKKTIEDGIHTADI 318 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 160 bits (405), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 114/357 (31%), Positives = 179/357 (50%), Gaps = 36/357 (10%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS--HHGKM-MPDDWH 63 + I GDGIG E+ + + + F+ + ++W + GK +PDD Sbjct: 57 VTLIEGDGIGPEI---------SQSVKDIFSAANAPIKWEPVDVTPILKDGKTAIPDDAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G + P H+SL L RR F+ + N+RP R G P Sbjct: 108 ESVRRNYVALKGPLATP-VGKGHVSLN---LTLRRTFNLFANVRPCRSIAGYKTPY---- 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V +G VV + T+ +R+LR+AF+ A+S + Sbjct: 160 -DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITKEASERVLRFAFQYARSINK 214 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 K + K+ + +S + +A+++P++ +D + +D C + V P ++ V+V Sbjct: 215 KKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLV 274 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A + Sbjct: 275 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDE---CSIFEAVHGSAPDIAGKGLANPTALL 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICK 357 + MML +G + I AI + +A G T D+ G A T + A+AI K Sbjct: 332 LSSIMMLQHMG-----LHEHAGRIQKAIFDTLAEGKALTGDLGGKAKTSEYAEAIMK 383 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 160 bits (405), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 120/354 (33%), Positives = 181/354 (51%), Gaps = 30/354 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRIA I GDG+G E++ + +L ER+ F +++ A Y+ GK + D+ E Sbjct: 1 MRIAVIKGDGVGPEIMGATLSLL----ERY-IGADFIEIK-AGKSYFIEEGKPIEDNAIE 54 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D++ G V P P + S+ +LL RREF Y N+RP R + G+ Sbjct: 55 KIRECDSLLKGPVATPTKGPSYPSV-NTLL--RREFKLYANVRPFRSYEGISIR------ 105 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID +VREN E Y E + + I V T+RG +RI +AF LA+ R Sbjct: 106 -RIDTILVRENLECLYYGW-----EVEDEDRAIAMRVITKRGAERISEFAFNLAKREGRG 159 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K N L + + + +A + ++R D + +D + V FDV++ N Sbjct: 160 RVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVMLTPN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSD+ G+IG+ SA + + F + FEP+HG+ DI GK +ANPI I A Sbjct: 219 LYGDILSDVAAGVVGSIGLCGSAQIGED--FAA-FEPIHGTGEDIAGKGVANPIGMIIAA 275 Query: 305 AMMLDFLGNGDERFQQAHNG--ILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 +MMLD+L ER + G I A++ VI TPD+ G+ T QV + I Sbjct: 276 SMMLDWLW---ERGRSPKRGEKIREAVDSVIRDRILTPDLGGDFRTEQVVEKIV 326 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 159 bits (402), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 120/374 (32%), Positives = 186/374 (49%), Gaps = 29/374 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T ++ +PGDGIG EV+ E R++ + G A SFE + Y + D Sbjct: 1 MATHKLLLLPGDGIGTEVMAEVSRLIDWL-NKAGIA-SFETEHGLVGGAAYDADKVAITD 58 Query: 61 DWHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 DA+ FGAVG P D VP LL+ R++ + NLRP +P + Sbjct: 59 ATMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEA 118 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAF 175 L + +D +VRE T G Y + + G + I V+ ++RI R AF Sbjct: 119 SSLKPEVVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAF 178 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERV-EAMAENYPEIRWDKQHIDILCARFVMQP 234 +LA+ R R +TS K N + + W+E + + A Y +++ + Q D V P Sbjct: 179 DLARKR-RNKVTSMEKRNVMKTGV-LWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWP 236 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGSAPDIY 290 ++FDV+V NLFGD+LSD+ TG++G+ PSA+L + +++EPVHGSAPDI Sbjct: 237 KQFDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIA 296 Query: 291 GKNIANPIATIWAGAMMLDF---LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA- 346 GK +ANP+A + + M L + +G ++ + AI V+A G +T D+K Sbjct: 297 GKGLANPVAMLASFGMALRYSLDMGELADKLDE-------AIAVVLARGLRTADIKSEGS 349 Query: 347 ---TTPQVADAICK 357 +T Q+ +AI + Sbjct: 350 TVVSTSQMGEAIVQ 363 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 113/351 (32%), Positives = 177/351 (50%), Gaps = 17/351 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG E + E +++ E ++ C Y +H + D Sbjct: 1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAYDAHGAAISEAD 60 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC-- 117 + L+ DA+ FGAVG P D+VP + LL+ R++ + NLRP +P + Sbjct: 61 MQKALAA-DAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRV-NEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERV-EAMAENYPEIRWDKQHIDILCARFVMQPE 235 +A++R + + S K N + S W++ V E Y +++ + D + V QP+ Sbjct: 180 MARTRQNR-VCSMEKRNVMK-SGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPK 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN-PERTF---PSLFEPVHGSAPDIYG 291 +FDV+V NLFGD+LSD+ TG++G+ PSA+L P+ +L+EPVHGSAPDI G Sbjct: 238 QFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 K IANPIA I + AM L + N + + + AI V+ G +T D+ Sbjct: 298 KGIANPIAMIASFAMCLRYSFN----MVKEADDLEKAIANVLDKGIRTGDI 344 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 157 bits (398), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 98/304 (32%), Positives = 152/304 (50%), Gaps = 19/304 (6%) Query: 12 GDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDA 71 GDGIG E++ + +L+ A R + E +E Y H+ + + E + R Sbjct: 12 GDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISEQSWESIERTGV 67 Query: 72 IYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYV 131 I + P T P + R+ + N+RP F P +++ + Sbjct: 68 I----LKAPITTPQGGGYKSLNVTIRKTLQLFANIRPSVSF----YPFTKTLHPNLNLTI 119 Query: 132 VRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATK 191 +REN E Y+ + R H + + +R G ++I+RYAFE A RK +T +K Sbjct: 120 IRENEEDLYAGIEYR----QTHNMYESVKLISRTGCEKIIRYAFEYAVKNNRKKVTCLSK 175 Query: 192 SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILS 251 N + S + + +A+ YP+I + IDI AR +PE FDV+V SNL+GDI+S Sbjct: 176 DNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVIVTSNLYGDIIS 235 Query: 252 DLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFL 311 D+ +G++G+A SAN+ ++FE VHGSAPDI G++IANP + A MML + Sbjct: 236 DVAAEISGSVGLAGSANIGEHY---AMFEAVHGSAPDIAGQDIANPSGLLNAAIMMLVHI 292 Query: 312 GNGD 315 G GD Sbjct: 293 GQGD 296 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 157 bits (396), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 104/360 (28%), Positives = 185/360 (51%), Gaps = 59/360 (16%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + + +PGDGIG E++ + I+++++ G+ ++ Y++ G + D ++ Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKSCIYT-GYKINI---------IYNYIGGISIDKFNT 51 Query: 65 QLSR--------FDAIYFGAVG---WPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRL 111 ++ D I+ G VG W ++ P++ LLK R++F+ + N+RP++ Sbjct: 52 PITNNLISIIKYIDTIFLGCVGGYKWNHSIFKPEY-----GLLKLRKKFNFFTNIRPIK- 105 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ--------ESVFT 163 CP +ID +VRE G Y G+ +G +++ Q ++ Sbjct: 106 -----CPFK-----NIDIIIVRELNGGIYY---GK-PKGFSKQIINQIPTWYAYNTKIYN 151 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHI 223 + + R+ R +F LA +R +K L S KSN L + W + + + + Y +++ +I Sbjct: 152 EQEIIRLARISFNLALNRKKK-LCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYI 209 Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D + +FDV++ SNLFGDI+SDL TG++G+ PS ++N + SLFEP H Sbjct: 210 DYATIDLIKNFNKFDVIITSNLFGDIISDLCSLLTGSLGMLPSISINNKSL--SLFEPCH 267 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 GSAPDI KNIANP+ + + MM +++ N + N + +I +V+++G T DMK Sbjct: 268 GSAPDIANKNIANPVGALLSLVMMFEYVLND----FKLSNNLYYSIYKVLSYGFCTIDMK 323 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 155 bits (393), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 121/365 (33%), Positives = 187/365 (51%), Gaps = 30/365 (8%) Query: 1 MMKTMRIAA--IPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKM 57 M +T +I A IPGDGIG E++ + VL A FE ++A + G Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDA------LGSPFEWDSQYAGMAAIARVGDP 60 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRP-VRLFPGVP 116 +P + + + A+ P T P ++ R+EF+ + N+RP + L PG Sbjct: 61 LPRETIQSIHHNKL----ALKGPLTTPTGGGYRSVNVQLRKEFELFANVRPALTLIPG-- 114 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-HEVVIQESVFTRRGVDRILRYAF 175 + ++D ++REN +G Y++ + G + H V + TR G RI+RYAF Sbjct: 115 -----GRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIRYAF 169 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP-EIRWDKQHIDILCARFVMQP 234 E A RK +T K+N L + E + +A+ Y I ++++ +D + V+ P Sbjct: 170 EYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLVLDP 229 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 RFDV+V +NLFGDILSDL G +G+AP N+ + ++FE VHGSAPDI GK I Sbjct: 230 GRFDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIGKQ---AAIFEAVHGSAPDIAGKGI 286 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 ANP+A + A AMMLD +G D + + + +E+ G +TPD+ G A T ++ A Sbjct: 287 ANPLALMLAAAMMLDHVGKTDLATRLRNAIRITTLED----GIRTPDLGGTAKTRELTQA 342 Query: 355 ICKII 359 + I Sbjct: 343 LISRI 347 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 155 bits (392), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 124/386 (32%), Positives = 174/386 (45%), Gaps = 52/386 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M RI +PGDGIG EV+ + V+ AA F L + W + + G+ +P Sbjct: 5 MLRKRICVLPGDGIGIEVMEAALPVI--AALNLPFDLVPADIGW---QCWRAEGETVPAR 59 Query: 62 WHEQLSRFDAIYFGAVG----------WPDTVPDHISLWGS-LLKFRREFDQYVNLRPVR 110 E ++ DA GA+ P T+ + S +++ R+ D Y N+RPV Sbjct: 60 TWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVT 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYS-------------------SLGGRVNEGT 151 G F V+RENTEG Y+ +LG Sbjct: 120 DMTG---------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + + + + TR G+ RI YAFE A+ +T K L S + EA A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP++ +++D + V +PERF V+VA N+FGDILSDLG G +G APS N Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 + FEPVHGSAP G N ANP A A A+ML+ LG F I A+ Sbjct: 291 SGAY---FEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLG-----FPTESACISQAVSL 342 Query: 332 VIAHGPKTPDMKGNATTPQVADAICK 357 V +T D+ G+ TT QV +AI + Sbjct: 343 VSRTSTRTYDLGGSHTTAQVGEAIVQ 368 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 155 bits (391), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 122/373 (32%), Positives = 175/373 (46%), Gaps = 34/373 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E I+VL+A A F Q H + D Sbjct: 1 MATHNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGS---------LLKFRREFDQYVNLRPVRL 111 + DA+ GA+G P+ WG+ LLK R+E Y NLRP Sbjct: 61 EALNAAKAADAVLLGAIGGPE--------WGTSSTVRPEQGLLKLRKELGTYGNLRPCNF 112 Query: 112 FPGV---PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVD 168 PL + DF VVRE T G Y G R + E ++R + Sbjct: 113 ASESLVDSSPLKAEVCRGTDFIVVRELTGGIY--FGDRTEDDGSGYACDTEP-YSRAEIV 169 Query: 169 RILRYAFELAQSR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI R A LA ++ P + S K+N LA S + + +++ +P+++ + Q ID Sbjct: 170 RIARLAGFLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAA 229 Query: 228 ARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPV 282 V P + VV+ SNLFGDI+SD G+IG+ PSA+L + + ++EP+ Sbjct: 230 MLLVKNPRALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPI 289 Query: 283 HGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 HGSAPDI GK I NP+ TI + AMML + N + + + AA++ I +G KT D+ Sbjct: 290 HGSAPDISGKGIVNPVGTILSVAMMLRYSLN----LPKEADAVEAAVKAAIDNGTKTKDL 345 Query: 343 KGNATTPQVADAI 355 GNATT + +A+ Sbjct: 346 GGNATTSDMGNAV 358 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 123/367 (33%), Positives = 176/367 (47%), Gaps = 20/367 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMP 59 M +I +PGD +G+E+ E I+VL+A ++ R FE G +P Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFEN-HLIGGAAIDATGVPLP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D+ E + DA+ GAVG P + LLK R+E Y NLRP L Sbjct: 60 DEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDL 119 Query: 120 AGKQP---GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY-AF 175 + +P DF VVRE G Y G+ E V +T V RI R AF Sbjct: 120 SPIKPQFAKGTDFVVVRELVGGIYF---GKRKEDDGDGVAWDSEQYTVPEVQRITRMAAF 176 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN-YPEIRWDKQHIDILCARFVMQP 234 Q P + S K+N LA S W + VE +N +P ++ Q ID V P Sbjct: 177 MALQHEPPLPIWSLDKANVLASSR-LWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNP 235 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN--PER-TFPSLFEPVHGSAPDIY 290 + +++ SN+FGDI+SD G++G+ PSA+L P++ T L+EP HGSAPD+ Sbjct: 236 THLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLP 295 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 KN NPIATI + AMML N + I A+++V+ G +T D+ G+ +T + Sbjct: 296 -KNKVNPIATILSAAMMLKLSLN----LPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTE 350 Query: 351 VADAICK 357 V DA+ + Sbjct: 351 VGDAVAE 357 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 114/364 (31%), Positives = 183/364 (50%), Gaps = 19/364 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE--QMEWASCEYYSHHGKMMPDDW 62 MRI +P DGIG E++ + VL++A + L+F+ + + S E Y G + D+ Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKY---GTTLRDEV 57 Query: 63 HEQLSRFDAIYFGAVGWPDT-VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + +D + G D PD S FR D Y N+RP R P + + Sbjct: 58 LAKAKTYDGVILGTQSHADYPAPDKGGRNVSA-GFRIGLDLYANVRPARTRPFLTSNM-- 114 Query: 122 KQPGDIDFYVVRENTEGEY---SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 ++ +D ++RE TEG Y + G ++ I TR +RI R AFELA Sbjct: 115 REGRTMDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +K +T+ K+N ++ + E V +A ++PE+R D ID A V PERFD Sbjct: 175 MKR-KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+VA+N +GDI+SDL +G++G+A S + + HGSAPDI G++ ANP+ Sbjct: 234 VLVATNFYGDIISDLASELSGSLGLAGSMMASDTHCCA---QAQHGSAPDIAGQDKANPV 290 Query: 299 ATIWAGAMMLDFLGNGDER--FQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAI 355 + I + AM++ ++G + + A + AA++ V+ + +TPD+ GN + Sbjct: 291 SMILSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAFGQLV 350 Query: 356 CKII 359 K+I Sbjct: 351 AKVI 354 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 154 bits (390), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 114/334 (34%), Positives = 171/334 (51%), Gaps = 24/334 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRV-LQAAAERWGFALSFEQMEWASCEY-YSHHGKMMP 59 MK + I GDGIG E++ ++V L+A AE L E++E Y + + P Sbjct: 1 MKKVPITVAYGDGIGPEIMDATLKVILEAGAE-----LEIEKIEIGFKVYSMGNPSGIEP 55 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 W E L R ++ A P T P + R+ Y N+RP + + Sbjct: 56 SSW-ESLKR-TKVFLKA---PITTPQGGGFKSLNVTVRKALGLYANIRPCISYAPF---I 107 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 K PG ID ++REN E Y + R +G + ++ + TR+G +RI+RYAFE A+ Sbjct: 108 HTKHPG-IDLVIIRENEEDLYGGIEHR--QGVDSFQALK--IMTRQGTERIIRYAFEYAR 162 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 RK ++S TK N L I+ + + E +A+ YP+I + IDI A+ P+ FDV Sbjct: 163 CYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQSFDV 222 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V +NL+GDILSD+ G++G+ SAN+ E S+FE +HGSAP G+N+ANP Sbjct: 223 LVLANLYGDILSDVAVQIAGSVGLGASANIGHEY---SMFEAIHGSAPRRAGQNVANPSG 279 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI 333 + A ML +G + + +N L IEE I Sbjct: 280 LLLAAVQMLIHIGQ-NAVADRVYNAWLKTIEEGI 312 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 152 bits (385), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 119/369 (32%), Positives = 186/369 (50%), Gaps = 24/369 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M T IA + GDGIG EV+ E ++VL+ +R + + + Y++ G PD Sbjct: 1 MTTYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAM-GHAFPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISL-----WGSLLKFRREFDQYVNLRPVRLFPGV 115 + + DAI G +G I + G+LL RR ++ + N RPV L G+ Sbjct: 60 ETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGL 119 Query: 116 P--CPLAGKQPGD-IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL G+ ID ++RE G Y V + + + +I++ Sbjct: 120 AHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVK 179 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 FE++ R +K + + KSN L S+ W+E VE ++NYPE+ +D + Sbjct: 180 VGFEVSMKR-KKVMHNIHKSNVLKSSV-LWNEIVEEESKNYPEVEVKNILVDAAATYLCL 237 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P FDV+V N+FGDILSD G G++G+ PSA P++++ +EP HGSAPDI GK Sbjct: 238 NPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSY---YEPSHGSAPDIAGK 294 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGNA---T 347 IANP + I + A+ML+ + G E+ +A N + AA++ V +G T D+ +G A + Sbjct: 295 GIANPYSMIGSVALMLE-MSFGLEK--EAKN-LWAAMQAVFENGYSTSDLSKEGEANLVS 350 Query: 348 TPQVADAIC 356 T + D +C Sbjct: 351 TAEFGDLVC 359 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 152 bits (384), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 107/351 (30%), Positives = 165/351 (47%), Gaps = 27/351 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ PG GIG E+ QA + FA + ++W E Y+ D E+ Sbjct: 306 KVVLFPGHGIGPEIS-------QAVCDI--FAAAKVPIDWEHHEIYTKPINEAGDLIKEE 356 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 Y + P P + R++ + + N+RP R GV P + Sbjct: 357 SLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYS----- 411 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ++D +RENTEGEYS L V G VV + ++ + I RYAFE A+ RK Sbjct: 412 NVDLVTIRENTEGEYSGLEHAVVPG----VVENLKIISQPACENIARYAFEFARKNNRKK 467 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + + K+ + + + ++ YPEI + ++ ID +C + PE FDV+V NL Sbjct: 468 VVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEVFDVMVMPNL 527 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDI+SDL G +G+ S N++ +++E VHG+APDI G N ANP A + +G Sbjct: 528 YGDIVSDLCAGLIGGLGLTASGNISHT---CAVYEAVHGTAPDIAGLNKANPTALLLSGV 584 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAI 355 MML +G E F I A+ + ++ G T D+ G ATT A+ Sbjct: 585 MMLKAMGLQKEGF-----AIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAV 630 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 151 bits (381), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 116/367 (31%), Positives = 174/367 (47%), Gaps = 43/367 (11%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQA---------------AAERWGFALSFEQMEWASCE 49 MRI + G+GIG E+ IRV++A A +G AL + ++ Sbjct: 1 MRIGVLKGNGIGPEITAATIRVIEATGIQPEWDFIPIADEAVRLYGHALPPQVIQRIKDV 60 Query: 50 YYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPV 109 + ++ + H ++S +V + S+ ++ RRE + +VN RP+ Sbjct: 61 KFCIKAPLLAEKLHGRIS--------CTQTDGSVVTYPSINNAI---RRELNLFVNPRPI 109 Query: 110 RLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDR 169 R + G+ +G+ +D ++RE TE Y + +G E + + TR + Sbjct: 110 RGYVGI----SGRHE-KMDMVIMREITEDTYIGWEKPLEDGAAAEAIKR---VTRSASWK 161 Query: 170 ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 + +YAFE A+ RK ++ K+N L + + + +A YP+I D ID C Sbjct: 162 VSQYAFEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYS 221 Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P FDVVV N +GDI SDL G++G+AP AN+ S FE HG+APDI Sbjct: 222 VVRDPCWFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDS---ASTFEAAHGAAPDI 278 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATT 348 G ANPIA I +GA +L G G + I A+ VI G TPD+ G +TT Sbjct: 279 AGTGAANPIALILSGAELLAHAGYG-----KGSEAIREAVTRVIEAGRTLTPDLGGRSTT 333 Query: 349 PQVADAI 355 QVADAI Sbjct: 334 EQVADAI 340 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 150 bits (379), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 121/398 (30%), Positives = 179/398 (44%), Gaps = 62/398 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQME--WASCEYYSHHGKMMPDDWHE 64 + +PGDGIG +VLP+ IRVL+A GF ++ + W E + + G +PD + Sbjct: 6 VVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADIGW---ECWCNEGNALPDRTIQ 58 Query: 65 QLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 L + FGA+ P+ +S + ++ R+ F+ V +RP FP Sbjct: 59 LLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFP 118 Query: 114 GVP------CPLAGKQPGDIDFYVVRENTEGEYSSL-------------------GGRVN 148 G P G + +D V R+NTEG Y+ + N Sbjct: 119 GNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFAN 178 Query: 149 EGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 E E+ + + T++ RI AF+ A+ K +T K N L + +E + Sbjct: 179 TPGE-ELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQ 237 Query: 209 MAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN 268 + + YPEI +ID PE + V+VASNLFGD++SD G +G A S N Sbjct: 238 VQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAASGN 297 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKN--IANPIATIWAGAMMLDFLGNGDERFQQAHNGIL 326 + E ++FEP HGSAP N I NPIA I + AMMLD +G E+ + I Sbjct: 298 IGDEV---AVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHIGE-SEKADRIRKAIA 353 Query: 327 AAIEE---------VIAHGPKTPDMKGNATTPQVADAI 355 ++E IA GPK+ +G A T Q+ DAI Sbjct: 354 DVVKEGKVRTYDMMRIAGGPKSL-AQGAANTVQITDAI 390 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 149 bits (377), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 109/350 (31%), Positives = 173/350 (49%), Gaps = 26/350 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSH-HGKMMPDDWHEQ 65 I GDG+G E++ + +L+ A +S E ++ +Y + P W E Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARAD----VSIETVDIGHNQYKKEWTSGIAPSAW-ES 64 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 +SR + P H SL +L R+ YVN+RP + P+ G + Sbjct: 65 ISRTRLLLKAPTMTPQG-SGHKSLNVAL---RQRLGLYVNVRPCVSY----FPVVGTKHP 116 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D+D ++REN E YS + +++E T HE V + TR ++I YAF A++ RK Sbjct: 117 DLDVVIIRENEEDTYSGVEHKLSEDT-HECV---KISTRSASEKICAYAFNYARAHNRKK 172 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K N + ++ + +A+ YP+I + +D+ A+ PE FDVVV +NL Sbjct: 173 VTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVVVTTNL 232 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDI+SD+ +G+IG+ SAN+ + ++FE VHGSAPDI GKN+ANP + A Sbjct: 233 YGDIVSDIVSLSSGSIGLTGSANIGD---YYAMFEAVHGSAPDIAGKNVANPSGLLNAAV 289 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 ML +G D + N L +E+ G T D+ T+ + A + Sbjct: 290 QMLVHIGQLD-KAGVIRNAFLKTLED----GVHTADIYSEKTSLRRASTM 334 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 149 bits (376), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 115/365 (31%), Positives = 180/365 (49%), Gaps = 50/365 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY---YSHHGKMMPDDWH 63 ++ I GDGIG E+ ++ AA +EW SC+ + + +PD Sbjct: 39 VSFIEGDGIGPEISKSVKKIFSAANV---------PIEWESCDVSPIFVNGLTTIPDPAV 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + +++ G + P H SL L R+ F + N+RP + G Sbjct: 90 QSITKNLVALKGPLATP-IGKGHRSLN---LTLRKTFGLFANVRPAKSIEGFKTTYE--- 142 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV---VIQE-SVFTRRGVDRILRYAFELAQ 179 ++D ++RENTEGEYS G EH V V+Q + TR +R++RYAFE A+ Sbjct: 143 --NVDLVLIRENTEGEYS--------GIEHIVCPGVVQSIKLITRDASERVIRYAFEYAR 192 Query: 180 S--RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + RPR + + LA + + + +++ YP++ + + ID + V P + Sbjct: 193 AIGRPRVIVVHKSTIQRLADGL--FVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAY 250 Query: 238 D--VVVASNLFGDILSDLGPACT-GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 V V NL+GDILSDL + G++G+ PSAN+ + S+FE VHGSAPDI G++ Sbjct: 251 TDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKI---SIFEAVHGSAPDIAGQDK 307 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP--KTPDMKGNATTPQVA 352 ANP A + + MML+ +G + Q N +L+ IA GP +T D+ G ATT Sbjct: 308 ANPTALLLSSVMMLNHMGLTNHA-DQIQNAVLST----IASGPENRTGDLAGTATTSSFT 362 Query: 353 DAICK 357 +A+ K Sbjct: 363 EAVIK 367 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 148 bits (374), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 113/382 (29%), Positives = 173/382 (45%), Gaps = 34/382 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQA-AAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 +T +I +PGDGIG EV+ E RVL+ +A + E ++ C HG+ + Sbjct: 4 RTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSI-DKHGEPLTAA 62 Query: 62 WHEQLSRFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG---VPC 117 E DAI GA+G P V + +LL R+ Y N+RP Sbjct: 63 TLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYS 122 Query: 118 PLAGKQPGDIDFYVVRENTEGEY----SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 PL +D V+RE G Y LG R E + +I ++ V RI R Sbjct: 123 PLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMI----YSVPEVQRITRS 178 Query: 174 AFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 ++A P + S K+N LA S + E + +P+++ D +D V Sbjct: 179 RRQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVAN 238 Query: 234 PERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPS----------LFEPV 282 P++ + V++ NLFGDILSD G++G+ PSA+L +P+ ++EP+ Sbjct: 239 PKKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPI 298 Query: 283 HGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP----- 337 HGSAPDI G+ IANPI TI + AM L ++ I AA+E G Sbjct: 299 HGSAPDIAGQGIANPIGTILSAAM----LCGTRSVWRSPAKAIEAAVEGARRQGDRREGL 354 Query: 338 KTPDMKGNATTPQVADAICKII 359 +T D+ G++ T + + +I+ Sbjct: 355 RTADLGGSSKTKDIGHKVVEIL 376 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 148 bits (373), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 117/373 (31%), Positives = 186/373 (49%), Gaps = 28/373 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQME-WASCEYYSHHGKMMPD 60 M ++ +PGDGIG EV+ + R++ + + FE E Y HG P Sbjct: 1 MAAKKLLILPGDGIGVEVMAQVRRIIDWMGRKR--KIEFEITEGLLGGAAYDVHGTPYPA 58 Query: 61 DWHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + E DA+ GAVG P D +P LL R++ + NLRP + + Sbjct: 59 ETLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADA 118 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVN---EGTEHEVVIQESVFTRRGVDRILRY 173 L + +D ++RE T G Y ++ +GT V+T + RI R Sbjct: 119 STLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGY--NTLVYTTPEIQRIGRV 176 Query: 174 AFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 AF+LA+ R +K L S K+N L ++ + +E ++ E +P++ ++D + V Sbjct: 177 AFDLARKRNKK-LCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRN 235 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIY 290 P++FDV+V N+FGDILSD TG++G+ PSA+L + + +L+EPVHGSAPDI Sbjct: 236 PKQFDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIA 295 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNG--ILAAIEEVIAHGPKTPDM----KG 344 GK++ANP+ATI + AM L + F A I A++ V+ G +T D+ K Sbjct: 296 GKDMANPLATIMSFAMCLRY------SFDMAAEADLIETAVKNVLKGGLRTADIMQPGKA 349 Query: 345 NATTPQVADAICK 357 +T + +A+ + Sbjct: 350 KVSTTVMGEAVVR 362 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 148 bits (373), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 105/350 (30%), Positives = 157/350 (44%), Gaps = 29/350 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+T + +PGDG G E++ VL AA GF + ++ + A + ++PD Sbjct: 1 MRTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWD-VHQAGQRALAESESLLPDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + A A+ P T P + R+E D Y LRPVR P Sbjct: 60 TLNSIRTNGA----ALKGPTTTPIGTGHRSVNITIRQELDLYACLRPVRSLPIASTQEEP 115 Query: 122 KQPGDIDFYVVRENTEGEYSSLG---------------GRVNEGTEHEVVIQESVFTRRG 166 ++P +D VVRENTE Y+ L G + + + FT G Sbjct: 116 ERP-HVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPFTPHG 174 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +R++ +AF A RK + S + + + +A +P I + L Sbjct: 175 CERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVPVPAL 234 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 CA V P R DV+V NL+GDI+SD+ A G++G+AP AN+ ++FE HGSA Sbjct: 235 CADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAHH---AVFEATHGSA 291 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG 336 P+ G NP A I++G M+LD LG + I AA+E+V+A G Sbjct: 292 PEFAGSGRLNPTALIFSGCMLLDHLGE-----HETAARIRAAVEDVVAAG 336 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 147 bits (371), Expect = 5e-34, Method: Compositional matrix adjust. Identities = 113/352 (32%), Positives = 172/352 (48%), Gaps = 28/352 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I + GDGIG EV+ + RV+ + A E Y G + DD Sbjct: 6 KILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVED-ALVGGAAYDAQGTPLHDDTVAL 64 Query: 66 LSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 DA+ GAVG W ++P + LL+ R++ + + NLRP +F + L Sbjct: 65 ALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAEASTLK 124 Query: 121 GKQPGDIDFYVVRENTEGEY-------SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 + +D +VRE T G Y S+L G + V+ + R+ + Sbjct: 125 TELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRG------VNTQVYDTHEIVRVAKV 178 Query: 174 AFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 AF+LA R ++ L S K+N + + W E V + +YPEI + D + V Q Sbjct: 179 AFDLAGKRGKR-LCSVEKANVMESGL-LWREEVTKLGADYPEIALSHMYADNCAMQLVRQ 236 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIY 290 P++FDV+V NLFGDILSD TG++G+ PSA+L + +++EPVHGSAPDI Sbjct: 237 PKQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIA 296 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 G++ ANP+ATI + +MML + + E N A+ V+A G +T D+ Sbjct: 297 GQDKANPLATILSFSMMLRYSFDLAEEADLVDN----AVRGVLAKGLRTGDI 344 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 147 bits (371), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 104/356 (29%), Positives = 173/356 (48%), Gaps = 35/356 (9%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP-DDWHEQ 65 + IPGDGIG PE + +Q G + FE++ + + + ++ Sbjct: 53 VTLIPGDGIG----PEMVVAVQDIFRHIGVPVDFEELNLSGLDIKDEDSYLGAFNEAITS 108 Query: 66 LSRFDAIYFGAVGWP-DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + R G + P D +P SL L+ R D + N+ + PG+ + Sbjct: 109 IKRNGVAMKGNIFTPLDAIPGFRSLN---LELRVHLDLFANIVRCKSIPGIQT-----RH 160 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFELAQS 180 ++D ++R+NTEGEYS L EHE V+ V T +I +YAF+ A+ Sbjct: 161 NNVDLVIIRQNTEGEYSHL--------EHENVSGVIENLKVTTEEACMKIAQYAFDFAEK 212 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T+ K+N + + + E M+ +YP I ++ ID C + V P++FDV+ Sbjct: 213 HDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVM 272 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIA 299 V NL+G+I+S++G + G GI P N+ + ++FE + DI GK+I+NPI+ Sbjct: 273 VLPNLYGNIVSNIGASLVGGPGIVPGENIGGDY---AIFESGSRHTGLDIQGKDISNPIS 329 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 ++A +ML+ L F + I +AI +V+ G T D+ G+ TT Q A+ Sbjct: 330 MLFASTLMLEHL-----EFTAYADLINSAILKVVQRGVLTADVGGSHTTTQFLSAL 380 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 147 bits (370), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 115/369 (31%), Positives = 174/369 (47%), Gaps = 46/369 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + GDGIG+E++ ++A G + +EQM+ E + G + D + Sbjct: 36 VLTFDGDGIGREIVSAAKECIEAT----GVNIRWEQMDMGY-EAMQNTGVYIDDSHMDAF 90 Query: 67 SRFDAIYFGAVGWPDTVP-----DHISLWGSLLK-----FRREFDQYVNLRPVRLFPGVP 116 ++ G P TVP ++ + G FR+ F + N+RPVR PGV Sbjct: 91 EEIGVLFKG----PLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P D+D V+RENTE Y+ V+ T H V +R +R+ ++F+ Sbjct: 147 APF-----NDVDLVVIRENTEDVYTGEETWVDADTVHCV----KRISRGASERVADFSFK 197 Query: 177 LAQSRPRKTLTSATKSNGLAIS----MPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 A+ RK +T+ K+N S + + ER A A + I D Q D + ++ Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHER--AAATDLGGIIADDQLADSCLTKLMI 255 Query: 233 QPERFDVVVASNLFGDILSDLG----PACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 +P+ FDV+ NL+GD+++ L G++G+ PS N+ T +LFEP HGSAPD Sbjct: 256 EPKSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG---THQALFEPAHGSAPD 312 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 I GK IANP + I +G MML LG E Q+ N A+ + A G D G A T Sbjct: 313 IAGKGIANPTSQILSGCMMLSHLGEF-EASQRLEN----ALRAMYASGIVPVDFGGQADT 367 Query: 349 PQVADAICK 357 +V A+ K Sbjct: 368 KEVVAAVLK 376 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 146 bits (369), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 25/341 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + GDGIG E+ + +L AA G L E +E Y + +P + + + Sbjct: 24 VTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEAWDSI 79 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +R + G P T P + R+ Y N+RP R + P+ + D Sbjct: 80 ARTRVMLKG----PITTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK----PIVTTRHPD 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 +D +VREN E Y+ + R + +V + TR G +RI RYAFE A+ R + Sbjct: 132 MDVVIVRENEEDLYAGIEHRQTQ----DVAQCLKLITRSGSERIARYAFEYARQHGRSKI 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T K N + ++ + + +A YPEI+ Q +D A FV +PE +DVV+ NL+ Sbjct: 188 TCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVLLPNLY 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSD+ TG++G+ S N+ + ++FE +HGSAPD+ +++ANP + A Sbjct: 248 GDILSDIAAQMTGSVGLGGSVNIG---SGGAIFEAIHGSAPDL-ARDVANPSGLLLAAVE 303 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 ML L D + N L +EE G T D+ G T Sbjct: 304 MLRHL-KLDSIAAKVMNAWLCTLEE----GIHTVDIAGAHT 339 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 144 bits (364), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 122/358 (34%), Positives = 177/358 (49%), Gaps = 48/358 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 ++T+RI IPGDGIGKEV+P G R+L+A G F + A E + G +PD Sbjct: 3 IRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDL-HAGFETFERTGAALPDK 61 Query: 62 WHEQL-SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L + D FGAV P + S ++ R++ D Y N+RPV+ L+ Sbjct: 62 TVEILRNECDGALFGAVSSPSSPVKGYS--SPIVALRKKLDLYANVRPVKTV------LS 113 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +P ID +VRENTE Y V E T TR D + A + Sbjct: 114 AAKP--IDMVIVRENTEDLY------VKEET-----------TRDTPDGKVAEAIKRISE 154 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R + AT + +A+ R + A P I + +++ + +V+ Sbjct: 155 RASHRI--ATMAGDIAL------RRQKIRAAGAPSIHQSPLVTITHKSNVLLRLK--NVI 204 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V NL+GDILSD A G++G+ PSAN+ F ++ EP HGSAPDI G+NIANPIAT Sbjct: 205 VDPNLYGDILSDDAAALVGSLGLVPSANVG--EGF-AIGEPCHGSAPDIMGQNIANPIAT 261 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICK 357 + + A+ML+FL DE + A I AA++ + G +PD+ G A T +V + I + Sbjct: 262 LRSAALMLEFL---DE--EAAAAKIYAAVDANLTEGKLLSPDLGGTAKTTEVIEDILR 314 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 143 bits (361), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 111/376 (29%), Positives = 181/376 (48%), Gaps = 38/376 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 +K +I +PGDGIG EV+ E +V+ ++ C Y HG + D+ Sbjct: 4 IKKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSY-DKHGTPITDE 62 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQ-----------YVNLRPVR 110 + + + GAVG P W +L +F ++ ++ + NLRP Sbjct: 63 VFYKALESEFVMLGAVGGPK--------WDNL-EFSKKPERALLKLRKELKLFANLRPAI 113 Query: 111 LFPGV--PCPLAGKQPGDIDFYVVRENTEGEY--SSLGGRVNEGTEHEVVIQESVFTRRG 166 F + L + +D +VRE T G Y G + E E + + S +T Sbjct: 114 CFEQLVDASTLKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHS-YTTSE 172 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 + R+ + AF+LA+ R + +TS KSN + + +E E + Y ++ D Sbjct: 173 IVRVAKVAFDLARKRSNR-VTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNC 231 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVH 283 + + P++FDV+V NLFGD+LSD TG++G+ PSA+L N + +++EP+H Sbjct: 232 AMQLLKNPKQFDVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIH 291 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM- 342 GSAPDI GK IANPIA+I + AM L + + D + + A+++V+ G +T D+ Sbjct: 292 GSAPDIAGKEIANPIASILSFAMALRYSLDLDSE----ADALEKAVQDVLNDGLRTKDIL 347 Query: 343 ---KGNATTPQVADAI 355 K +T + DAI Sbjct: 348 SQGKKEVSTSAMGDAI 363 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 142 bits (359), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 111/358 (31%), Positives = 176/358 (49%), Gaps = 36/358 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK----MMPDD 61 + A + GDGIG EV+ +RVL+ + L A E + +G+ +PD Sbjct: 4 KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILC-----EAGSEQWDKNGRKDASYIPDV 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L D + G T+P + + R++FD Y N+RP + + + Sbjct: 59 TMKILEETDCCFKGPTT---TIPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRLT----- 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D RE TEG Y+ + ++ + + I TR+G R++ A + A Sbjct: 111 -PDRKLDCVCFREATEGLYTGVEAKITD----DAAIAIRKITRQGSRRLIDSAVDWANKF 165 Query: 182 PRKTLTSATKSNGLA-ISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-- 238 K + + TK N L +WDE +A+ +I + +ID + + V+ E+F+ Sbjct: 166 NMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQMVIATEQFNGA 223 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V++NLF DI+S+L A G+IG+ SAN+ ++FE HGSAP G+N NP Sbjct: 224 VLVSTNLFMDIISELASALVGSIGLIYSANIGDNY---AMFEAAHGSAPQFAGQNKVNPT 280 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAI 355 AT+ +GA M D+LG D R + I AA E+VI G T D+ G+A+T Q+ DAI Sbjct: 281 ATVLSGAWMADYLGERDVR-----DAIFAATEQVINEGKAVTWDIGGDASTTQMTDAI 333 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 142 bits (357), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 107/380 (28%), Positives = 180/380 (47%), Gaps = 53/380 (13%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++IA +PGDGIG EV + V + L++ + W E++ G +P + Sbjct: 7 IKIAVLPGDGIGIEVTEATLPVFEVL--DVPVILNYGDIGW---EFWKKEGAAIPSRTWQ 61 Query: 65 QLSRFDAIYFGAV--------------GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 ++ D + GA+ + P ++S +++ R+ D + N+RP Sbjct: 62 LIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVS---PVIQLRQGLDLFANVRP-- 116 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQES---------- 160 C Q +F ++REN+EG Y H ++ + Sbjct: 117 ------CFSIDDQSKPFNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEA 170 Query: 161 -----VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE 215 + ++ G+ R+ +AF+ A +T A K N L S + + E+ A+ YP+ Sbjct: 171 SCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPK 230 Query: 216 IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTF 275 I+ D ++D + + PE+F V+VA N+FGDILSD+G G +G+APSAN+ + ++ Sbjct: 231 IQADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSY 290 Query: 276 PSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 FEPVHGS P I KN ANP A +M+L+ G D R ++ N ++ I+E Sbjct: 291 ---FEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPD-RAKKIVNAVMQVIKE---K 342 Query: 336 GPKTPDMKGNATTPQVADAI 355 T D+ G+ATT +A+A+ Sbjct: 343 RFITYDLGGHATTTDMANAV 362 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 139 bits (351), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 113/381 (29%), Positives = 180/381 (47%), Gaps = 41/381 (10%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER---WGFALSFEQMEWASCEYYSHHGKM 57 M + ++ +PGD IG E++ E +++L E + +S+ + AS + G Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLD---KTGSA 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPD--TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + D+ E DA+ G+VG P+ VP +S +L R+ D + N+RP R + Sbjct: 58 ITDEVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASS 117 Query: 116 ---PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL + +DF +VREN G Y GT+ E + R V+R R Sbjct: 118 LLNQSPLKPEIAAGVDFVLVRENCGGAYF--------GTKTEFEDE----ARTEVERCAR 165 Query: 173 YAFELAQSRPRKTLT---------SATKSNGLAISMPYWDERVEAMAE-NYPEIRWDKQH 222 + LA++ R T +A K+N LA S +W + E +P+I Q Sbjct: 166 VSAALARTFGRGKNTDDKSPAIVWNADKANVLA-SGRFWRTVTHDIFEREFPDIELHDQL 224 Query: 223 IDILCARFVMQPERFDVVVAS-NLFGDILSDLGPACTGTIGIAPSANL----NPERTFPS 277 D + V P +F+ V+ + N FGDILSD+ G++G+ PSA++ E+ Sbjct: 225 ADSMAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKG 284 Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE--EVIAH 335 ++E VHGSAPDI G ANPIA I + AM+L + + + + + +E E Sbjct: 285 IYEAVHGSAPDISGTGQANPIAQILSLAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGL 344 Query: 336 GPKTPDMKGNATTPQVADAIC 356 G +T D+ G+A+T V DA+ Sbjct: 345 GIRTKDLGGSASTQDVGDAVA 365 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 138 bits (348), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 115/377 (30%), Positives = 165/377 (43%), Gaps = 39/377 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+ + I GDG G E++ VL AA GF L ++ + A G+++P Sbjct: 1 MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWD-VRPAGQGALRSVGELLPAS 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + R G P T P + + RRE D Y +RPVR++PG AG Sbjct: 60 TLDSIRRNGVALKG----PTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPG-----AG 110 Query: 122 KQPGDIDFYVVRENTEGEYSSL-------GGRVNEGTEHE-------VVIQESVFTRRGV 167 ID VVRENTE YS L G V T E + T G Sbjct: 111 AVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPITPGGS 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI+ +A + A+ R+ + + + E + YP+I + +LC Sbjct: 171 RRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPVTVLC 230 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 V P DV+V NL+GD++SD+ A G +G+AP AN+ +RT ++FE HGSAP Sbjct: 231 DSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIG-DRT--AVFEATHGSAP 287 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKT------PD 341 + G N NP A I +G M+LD LG + I AA+ V+ G PD Sbjct: 288 EFAGSNRLNPTALILSGCMLLDHLGEAPTAAR-----IRAAVRSVLEEGRSVTFDLLPPD 342 Query: 342 MKGNA-TTPQVADAICK 357 A TT A+A+ + Sbjct: 343 RAARAVTTTAYAEAVIE 359 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 138 bits (347), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 110/362 (30%), Positives = 177/362 (48%), Gaps = 52/362 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM--MPDDWHE 64 + IPGDGIG V +V++A F E Y G M +P++ E Sbjct: 41 VTLIPGDGIGPLVTGAVEQVMEAMHAPVHF------------ERYEVLGNMRKVPEEVIE 88 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + R G + P V +S ++ R+E D + +L PG+ + Sbjct: 89 SVKRNKVCLKGGLATP--VGGGVSSLN--MQLRKELDIFASLVNCINVPGLV-----TRH 139 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV--IQES--VFTRRGVDRILRYAFELAQS 180 ++D V+RENTEGEYS G EHEVV + ES V T+ +RI RYAFE A Sbjct: 140 ENVDIVVIRENTEGEYS--------GLEHEVVPGVVESLKVITKFCSERIARYAFEYAYL 191 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T+ K+N + ++ + E +A++Y I +++ +D C + V +PE+FDV+ Sbjct: 192 NNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVM 251 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG------KNI 294 V NL+G+++++ G G+ P N+ E ++FE G++ G + Sbjct: 252 VTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEH---AIFE--QGASAGNVGNDKMVEQKK 306 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 ANP+A + + AMML L RF + + A+++VI G +T D+ G+ TT +V D Sbjct: 307 ANPVALLLSSAMMLRHL-----RFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVD 361 Query: 354 AI 355 A+ Sbjct: 362 AV 363 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 117/384 (30%), Positives = 173/384 (45%), Gaps = 64/384 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK--MMPDDWHE 64 I I GDGIGK+V P +VL+AAAE G +S+ ++ +A +G+ +PD+ Sbjct: 33 IPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRV-YAGESAREEYGEDVNLPDE--- 88 Query: 65 QLSRFDAI--YFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI + A+ P T P + R+ D Y N+RP GVP P+ K Sbjct: 89 ---TVDAIREHRVAIKGPLTTPVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPM--K 143 Query: 123 QPGDIDFYVVRENTEGEYSSLG--------GRVNEGTEHEVVIQESV-----------FT 163 P ++D RENTE Y+ + +V E E E+ E++ T Sbjct: 144 APEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPIT 203 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM-PYWDERVEAMAENYPEIR----- 217 +G R++R A + A R +T K N + + + D +E E YP+ Sbjct: 204 EKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVFAAP 263 Query: 218 ---WDKQH---------------IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTG 259 W+ Q D + ++ + FD++ NL GD LSD A G Sbjct: 264 DSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLSDAAGAQIG 323 Query: 260 TIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQ 319 +GIAP N R L EPVHGSAP G+++ANP A I +G +M D+LG + Sbjct: 324 GLGIAPGGNFGKGRM---LAEPVHGSAPKRAGQDMANPTAMILSGRLMFDYLG-----WD 375 Query: 320 QAHNGILAAIEEVIAHGPKTPDMK 343 A + I A+EE I+ G T D++ Sbjct: 376 DAADLIRDAVEETISSGKVTYDLE 399 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 135 bits (339), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 95/325 (29%), Positives = 156/325 (48%), Gaps = 23/325 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ GDG+G E++ + ++ A G + + +E Y + D E Sbjct: 3 KLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWET 58 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L R + + P T P + + R++ + N+RP + L + P Sbjct: 59 LKRNKVL----LKAPITTPRGGGVRSLNVTLRKKLGLFANIRPCK------SHLEWQDP- 107 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D ++REN E YS + R T + V T +RI RYAFE A+S RK Sbjct: 108 KMDIVIIRENEEDLYSGIEYRQTLDTYN----CTKVITESTSERICRYAFEYARSNGRKK 163 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K N + ++ + + + +A YP+I + IDI AR PE+FDV+V NL Sbjct: 164 VTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNL 223 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDI+SD+ +G++G+ S N+ E ++FE VHGSAPDI ++IANP + A Sbjct: 224 YGDIISDIAAEISGSVGLGGSINIGEEY---AMFEAVHGSAPDIADQDIANPSGLLNAAM 280 Query: 306 MMLDFLGNGDERFQQAHNGILAAIE 330 ML ++G E Q+ ++ L ++ Sbjct: 281 YMLSYIGQ-KEIAQKVYSAWLKTLK 304 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 133 bits (335), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 125/397 (31%), Positives = 175/397 (44%), Gaps = 71/397 (17%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI +PGDGIG E+ ++ W L+ Q+ W+ + HG +P + E Sbjct: 16 RITLLPGDGIGPEITDACRGLIADVFPHW--ELTETQIGWSQ---WRAHGNPVPQETWET 70 Query: 66 LSRFDAIYFGAVG-----------WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 L R DA A+ P ++ +L+ R+ D + N+RPV L PG Sbjct: 71 LGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPVTL-PG 129 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSS-----------------LGGRVNEGT------ 151 DF +VRENTEG YS L V E + Sbjct: 130 AAA----------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVARAV 179 Query: 152 --EHEVVIQESVFTRRGVDRILRYAFELAQSRPRK--------TLTSATKSNGLAISMPY 201 EV + V T R+ R A +LA +R T+T A K N L S Sbjct: 180 DKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSARV 239 Query: 202 WDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTI 261 VE +AE YP++ +D + D + + V P RFDV++A NL GDILSD+G G + Sbjct: 240 IRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLIGGL 299 Query: 262 GIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQA 321 G+A SAN+ ++FEPVHGSAPDI G+ IANP A + + AM + LG A Sbjct: 300 GLAASANVGDNF---AVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSELAPA 356 Query: 322 HNGILAAIEEVIAHGPKTP---DMKGNATTPQVADAI 355 A + E + +T D+ G ATT + A+ Sbjct: 357 -----AKLREAVYAATRTAPTLDLGGTATTSEFVAAV 388 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 133 bits (334), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 107/362 (29%), Positives = 173/362 (47%), Gaps = 48/362 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG PE R ++ + G + FE ++ D Sbjct: 90 VTLIPGDGIG----PEMARHVKTVLHKCGAPIDFEVIDIK--------------DESSTD 131 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSL---LKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + ++ +G T+ +IS S + RR+ D Y N+ P + PGV + Sbjct: 132 AAIISLKRNGIGLKGTITTNISNPQSQSINAQIRRKLDLYSNIVPCKSIPGV-----WTR 186 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFELAQ 179 G +D V+RENTEGEY SL EHE VV + T + RI ++AF+ A Sbjct: 187 HGQVDLVVIRENTEGEYGSL--------EHENVDGVVESLKIITEKKSRRIAKFAFDYAL 238 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R+ +T+ K+N + ++ + E ++++Y +I ++ ID C + V P++FDV Sbjct: 239 QNNRRKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFDV 298 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPI 298 +V NL+G+I+S +G G IG+ P N+ + ++FE D+ G N ANP Sbjct: 299 MVMPNLYGNIVSHIGIGLVGGIGLVPGKNIGDKY---AIFESGARNIGSDLVGLNRANPC 355 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICK 357 ++ A+ML LG D + I +A+ I +G +TPD++G+ TT DA+ K Sbjct: 356 GFLFTSALMLRHLGLDD-----YADIIESAVRTTIKNGKCRTPDIQGDRTTADFIDAVIK 410 Query: 358 II 359 I Sbjct: 411 EI 412 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 132 bits (332), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 124/413 (30%), Positives = 181/413 (43%), Gaps = 82/413 (19%) Query: 10 IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQ-MEW----ASCEYYSHHGKMMPDDWHE 64 I GDGIG ++ RV+ AA E+ A + E+ +EW A + + G+ +P + + Sbjct: 24 IIGDGIGPDIWKAASRVIDAAVEK---AYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + Y AV P T P + + R+E D + LRPVR F GVP P+ K+P Sbjct: 81 TIKE----YLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPV--KRP 134 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT----------EHEVVIQESVF-----------T 163 D+D + RENTE Y+ G EGT ++E+ F + Sbjct: 135 QDVDMVIFRENTEDIYA--GIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVS 192 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI---SMPYW------------------ 202 + G +R++R A + A RK++T K N + S W Sbjct: 193 KEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQ 252 Query: 203 -DERVEAMAENYPEIRWDKQH-----------IDILCARFVMQPERFDVVVASNLFGDIL 250 DE VE + + +K DI + + +P DVV NL GD + Sbjct: 253 YDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYI 312 Query: 251 SDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDF 310 SD A G IGIAP AN+N E T ++FE HG+AP G N NP + I + +ML+ Sbjct: 313 SDALAAQVGGIGIAPGANINYE-TGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEH 371 Query: 311 LGNGDERFQQAHNGILAAIEEVIAHGPKTPD----MKG--NATTPQVADAICK 357 LG +Q+A + I +IE+ IA T D M G +T AD + K Sbjct: 372 LG-----WQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIK 419 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 132 bits (332), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 119/403 (29%), Positives = 177/403 (43%), Gaps = 68/403 (16%) Query: 10 IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRF 69 I GDGIGK+V P +VL+AAA G +S+ ++ +A + + +PDD + Sbjct: 38 IHGDGIGKDVGPAAQKVLEAAANATGREISWMRV-FAGESAREKYDENLPDDTVNAIDE- 95 Query: 70 DAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDF 129 + A+ P T P + R+ D Y N+RP GVP P+ K P ++D Sbjct: 96 ---HRVAIKGPLTTPVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPM--KAPEEMDM 150 Query: 130 YVVRENTEGEYSSLGGRVNEGTEHEVVIQESV---------------------FTRRGVD 168 RENTE Y+ + GTE ++E V T G Sbjct: 151 VTFRENTEDVYAGI--EWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGSK 208 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE-RVEAMAENYPEIR--------WD 219 R++R A + A R +T K N + + + E +E E YP+ W+ Sbjct: 209 RLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVFAAPDSLWE 268 Query: 220 KQ-HIDI--------------LCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIA 264 Q IDI + ++ + F V+ NL GD LSD A G +GIA Sbjct: 269 TQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSDAAGAQIGGLGIA 328 Query: 265 PSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 P AN R L EPVHGSAP G+N+ANP A I +G +M D++G ++ A + Sbjct: 329 PGANFGDARV---LAEPVHGSAPKRAGQNMANPTAMILSGRLMFDYMG-----WKDAADL 380 Query: 325 ILAAIEEVIAHGPKTPDMKGNAT------TPQVADAICKIILR 361 + A+EE I+ G T D++ T + +DAI + I + Sbjct: 381 VRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 131 bits (330), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 105/362 (29%), Positives = 169/362 (46%), Gaps = 52/362 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A + GDG+G E+L V Q G + FE++ + E Sbjct: 71 VAMLLGDGVGPELLSYVKEVFQV----IGAPIDFEEVAV--------------NQESEDA 112 Query: 67 SRFDAIY------FGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + DA+ G G T P S +L R + Y ++ R FPGV Sbjct: 113 TFTDALLAMKRNGVGIKGNFATEPGQSSRNVAL---RLNLNLYAFVQRCRNFPGVVT--- 166 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFE 176 + ++D ++RENTEGEYS L EHE VV + TR RI ++AF+ Sbjct: 167 --RHQNVDIVIIRENTEGEYSRL--------EHENVPGVVESLKIITREKSTRIAQFAFD 216 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 A RK +T+ K+N + + + + ++A+NYP+I ++ ID C + V +P++ Sbjct: 217 YAVRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQ 276 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIA 295 FDV+V NL+G+I+ ++ G G+ NL P+ +LFE S + GKNIA Sbjct: 277 FDVIVLPNLYGNIVGNVAAGLVGGAGLTTGINLGPQN---ALFEMGTRNSGRSLAGKNIA 333 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP + A ML++LG+ E + + ++ I E +T D+ G+ T +V +A+ Sbjct: 334 NPCGMLLTSADMLEYLGHIKEA-KLIRDSVVDVIGE---QKIRTADLGGSFKTSKVIEAV 389 Query: 356 CK 357 K Sbjct: 390 LK 391 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 130 bits (326), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 100/365 (27%), Positives = 173/365 (47%), Gaps = 53/365 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 ++ IP DGIG+ ++ + V Q + G + FE+ C + D E++ Sbjct: 48 VSLIPADGIGQSLIMGIVEVFQNS----GVPVDFEE-----C-------YITGDTNEEKM 91 Query: 67 SRFDAIYFGAV--------GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 F+ I + W ++ + LL R + D Y N+ + +P V Sbjct: 92 KSFNDIKTSVLRNGTALKGNWATSMGIDSKSYNVLL--RHDLDLYANVVKFKSYPTVIT- 148 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYA 174 + ++D V+RENTEGEY++L EHE V+ + T++ +RI +YA Sbjct: 149 ----RHNNVDLIVIRENTEGEYTNL--------EHENIPGVIEMIKIITKKKSERIAKYA 196 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+ A RK +T+ K+N + +S + + + +AE YPEI ++ ID + V +P Sbjct: 197 FDYAMENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKP 256 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL-NPERTFPSLFEPVHGSAPDIYGKN 293 E+FDV+V NL+G++LS++ A G G+ N N F S S DI KN Sbjct: 257 EQFDVIVTPNLYGNVLSNIAAALVGGPGLPHGENHGNGIHVFES---GTRNSGMDIATKN 313 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVA 352 IANP++ ++A +L L + + I + I +++ + +T D+ GN +T + Sbjct: 314 IANPMSMLFAATALLRHL-----QLSKHAQLIESCIHKIVTTNQARTVDIGGNTSTSEFF 368 Query: 353 DAICK 357 + + K Sbjct: 369 EILVK 373 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 107/359 (29%), Positives = 166/359 (46%), Gaps = 44/359 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDG+GKE+ + +R + F ++W + K + E L Sbjct: 31 VTLIPGDGVGKEI-TDSVRTI--------FEAENIPIDWETINIKQTDHKEGVYEAVESL 81 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R G P H SL +L R++ D Y N+ + GV + D Sbjct: 82 KRNKIGLKGLWHTPADQTGHGSLNVAL---RKQLDIYANVALFKSLKGVKTRIP-----D 133 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFELAQSRP 182 ID V+RENTEGE+S G EHE VV V TR +RI R+AF+ A+ Sbjct: 134 IDLIVIRENTEGEFS--------GLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKYN 185 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAEN-YPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK++T+ K+N + + + + + + YP+I +D + V +P +FDV+V Sbjct: 186 RKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLV 245 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGS---APDIYGKNIANPI 298 +++G IL ++G A G G+ AN + ++FEP GS DI G+N+ANP Sbjct: 246 TPSMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEP--GSRHVGLDIKGQNVANPT 300 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAIC 356 A I + +ML+ LG + I A+ E IA G T D+ G+++T + I Sbjct: 301 AMILSSTLMLNHLG-----LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEII 354 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 129 bits (324), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 107/364 (29%), Positives = 159/364 (43%), Gaps = 48/364 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ V + A + FE++ +S D + Sbjct: 19 VTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSS-----------NADEEDIR 63 Query: 67 SRFDAIYFGAVGWPDTV-------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + AI V + P H S L R D Y N+ + PGV Sbjct: 64 NAIMAIRRNRVALKGNIETNHNLPPSHKSRNNIL---RTSLDLYANVIHCKSLPGVV--- 117 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAF 175 + DID +VRENTEGEYSSL EHE VV + T+ RI YAF Sbjct: 118 --TRHKDIDILIVRENTEGEYSSL--------EHESVAGVVESLKIITKAKSLRIAEYAF 167 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +LAQ RK +T+ K+N + + + + +A YP+I ++ +D + V +P+ Sbjct: 168 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQ 227 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V NL+G+I++++ G G+ AN + + I KNIA Sbjct: 228 QFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG--HVYAVFETATRNTGKSIANKNIA 285 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP AT+ A MMLD L +LA+++ H TPD+ G TT + I Sbjct: 286 NPTATLLASCMMLDHL-KLHSYATSIRKAVLASMDNENMH---TPDIGGQGTTSEAIQDI 341 Query: 356 CKII 359 + I Sbjct: 342 IRHI 345 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 129 bits (323), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 108/362 (29%), Positives = 167/362 (46%), Gaps = 40/362 (11%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG GIG PE + ++ + G + FE ++ DD + Sbjct: 59 VTMLPGGGIG----PECMGYVRDIFKYIGAPIDFEVVDIDPTMDND-------DDVQYAI 107 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + G G +T + + + R E D Y + + +PGV + D Sbjct: 108 TTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGV-----ATRHKD 162 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFELAQSRP 182 ID ++R+NTEGEY+ L EHE VV V T +R+ R+AFE A+ Sbjct: 163 IDVVIIRQNTEGEYAML--------EHESVNGVVESMKVVTADNSERVARFAFEFAKKNG 214 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T+ K+N + +S + E +A+ YP+I D ID C + V +P +FDV++ Sbjct: 215 RKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLM 274 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +NL+G I+S++ C G + N + ++FEP + I GKNIANPIA I Sbjct: 275 TNLYGSIVSNV--VCGLLGGAGLLSGRNYGDHY-AVFEPGTRNTGTAIAGKNIANPIAMI 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGIL-AAIEEVI-AHGPKTPDMKGNATTPQVADAICKII 359 A ML+ LG Q H +L AI + I TPD+ G+ T+ V AI + + Sbjct: 332 NASIDMLEHLG------HQFHASLLRRAINKTINVDRVLTPDLGGSNTSTDVVGAILQNV 385 Query: 360 LR 361 R Sbjct: 386 GR 387 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 108/368 (29%), Positives = 179/368 (48%), Gaps = 42/368 (11%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQ--AAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I GDGIG + + R+L+ + + F+ ++ + E + +P + + Sbjct: 44 IGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAEVLK 103 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSL----LKFRREFDQYVNLRPVRLFPGVPCPLA 120 +L I G P T P W ++ + R+E D + N+RPVR+ P Sbjct: 104 ELKECHVILKG----PTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRI------PEQ 153 Query: 121 GKQPGDIDFYVVRENTEGEYS--SLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 G ID+ RENTEG Y+ S G V E ++ + +V T G +RI+R AFE A Sbjct: 154 G-----IDWTFYRENTEGAYAVGSKGIHVTE----DLGVDFTVVTSGGSERIIRAAFEYA 204 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER-- 236 ++ + +T+ TK+N + + + + +A++Y +I D +IDI+ A+ + + R Sbjct: 205 KANGKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKD 264 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK---N 293 F V+V NL+GDI++D G +G A SAN+ S+FE +HGSAP + + Sbjct: 265 FQVMVLPNLYGDIITDEAAEFQGGVGTAGSANIGKRY---SMFEAIHGSAPRMVQEGRDQ 321 Query: 294 IANPIATIWAGAMMLDFLGNGDE--RFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 A+P + I AGAM+L +G G E + QA + ++++ G T AT + Sbjct: 322 YADPCSVIRAGAMLLAHIGYGKEADKLYQALDICTVTEKKLVITGRNT-----GATGAEF 376 Query: 352 ADAICKII 359 AD I + I Sbjct: 377 ADYIMETI 384 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 128 bits (321), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 106/364 (29%), Positives = 159/364 (43%), Gaps = 48/364 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ V + A + FE++ +S D + Sbjct: 57 VTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSS-----------NADEEDIR 101 Query: 67 SRFDAIYFGAVGWPDTV-------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + AI V + P H S L R D Y N+ + PGV Sbjct: 102 NAIMAIRRNRVALKGNIETNHNLPPSHKSRNNIL---RTSLDLYANVIHCKSLPGVV--- 155 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAF 175 + DID +VRENTEGEYSSL EHE VV + T+ RI YAF Sbjct: 156 --TRHKDIDILIVRENTEGEYSSL--------EHESVAGVVESLKIITKAKSLRIAEYAF 205 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +LAQ RK +T+ K+N + + + + +A YP+I ++ +D + V +P+ Sbjct: 206 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQ 265 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V NL+G+I++++ G G+ AN + + I KNIA Sbjct: 266 QFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG--HVYAVFETATRNTGKSIANKNIA 323 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP AT+ A MMLD L +LA+++ H TPD+ G TT + + Sbjct: 324 NPTATLLASCMMLDHL-KLHSYATSIRKAVLASMDNENMH---TPDIGGQGTTSEAIQDV 379 Query: 356 CKII 359 + I Sbjct: 380 IRHI 383 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 128 bits (321), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 118/362 (32%), Positives = 180/362 (49%), Gaps = 29/362 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T R+ G+GIG E++ ++ ++ A + G A E + G+++P++ Sbjct: 5 ETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEET 64 Query: 63 HEQLSRFDAIYFGA---VGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 E ++ D G V +P +V ++ L R++ D + N+RPVR PG P Sbjct: 65 WETITGLDGWILGPHDNVSYPPSVAGQLNPSAHL---RKQADLWANIRPVRGVPGAVHP- 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSS---LGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 D+D +VRENTEG Y+ L G + EV + VFT+ + RI+R A Sbjct: 121 ------DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRAAA 174 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 +A +R LT A KSN L + + +A AE + + HID LCA V +PER Sbjct: 175 IAAAR-DGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTRPER 232 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 + +VA N+FGDILSDL G++GIA S N + + + + HGSAPDI G+ IAN Sbjct: 233 YATIVAENMFGDILSDLAGGLGGSLGIAGSINASESQV---MAQAAHGSAPDIAGQGIAN 289 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGNATTPQVADA 354 P + + A MLD LG + QA + A+ E + P T D+ + A P+ A Sbjct: 290 PAGIMNSAAQMLDSLG-----YPQAAELLEGAVREAVVKAP-TADLVREAAAADPETATP 343 Query: 355 IC 356 + Sbjct: 344 VA 345 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 127 bits (318), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 99/360 (27%), Positives = 163/360 (45%), Gaps = 44/360 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPG GIG PE ++ E + F+ ++ + E DD QL Sbjct: 35 VTLIPGVGIG----PEITNSVKTVFEALHVPIKFDVLDNFNFE---------NDDSKSQL 81 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + I G + + + KF + D Y N+ G+ ++ + Sbjct: 82 RKNECILLGVMTEKN------QKYTDNYKFYKYLDLYSNITFAFSVEGIT-----QRHNN 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEV---VIQE-SVFTRRGVDRILRYAFELAQSRP 182 D V+RENTEGEYS G EHEV V++ V T++ RI YAFE A Sbjct: 131 TDIVVIRENTEGEYS--------GVEHEVYPGVVESIKVTTKQASLRIAEYAFEFAHLSG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R+ +T+ K+N + + + + +A+ Y I++++ ID C + V P +FDV+V Sbjct: 183 RRKVTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVMVM 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+G I+ ++ TG +G+A A++ + S + + DI GKN+ NP A + Sbjct: 243 PNLYGSIVQNVVAGITGGVGMAAGASIGKDHALFS--QGCRHTGRDIAGKNVVNPSAMLV 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIILR 361 + ++L LG + I A++ I KT D+ GNATT Q + + + R Sbjct: 301 SSTLLLRHLG-----LPNFADQICRAVQHTIQDKKIKTKDIGGNATTDQFTSEVIRSLGR 355 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 126 bits (317), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 107/360 (29%), Positives = 161/360 (44%), Gaps = 40/360 (11%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG+E + + A + FE+++ E + K D HE + Sbjct: 23 VTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDVTGME---KNNKSSGDALHEAI 75 Query: 67 SRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 G G P H S +L R+E D Y +L ++ PG + Sbjct: 76 QSLKRNKVGLKGILFTPFEKGGHTSFNVAL---RKELDIYASLVLIKNIPGFKT-----R 127 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFELAQ 179 ++DF ++RENTEGEYS G EH+ VV + T RI ++AF+ A Sbjct: 128 HDNVDFAIIRENTEGEYS--------GLEHQSVPGVVESLKIITEYKSKRIAQFAFDFAL 179 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 RK++T K+N + ++ + +A Y I +D + V +P++FDV Sbjct: 180 QNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPI 298 +V NL+G ILS++G A G G+ P AN + +LFEP I G+ ANP Sbjct: 240 LVMPNLYGSILSNIGSALVGGPGVIPGANFGRDY---ALFEPGCRHVGLSITGRGEANPT 296 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICK 357 A I + +ML LG + + I AA VI G T D+ G+A+T AI + Sbjct: 297 AAILSACLMLRHLG-----LKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILE 351 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 126 bits (316), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 111/378 (29%), Positives = 171/378 (45%), Gaps = 57/378 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA I GDG+G++V+P +V+ +A A ++ W K+ DW Q Sbjct: 34 IAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAK--RKIHWMQVYNGEQAAKLYDGDWFPQ- 90 Query: 67 SRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +A+ A+ P T P + R+E D +VN+R ++ F +P PL K P Sbjct: 91 ETINAVRECKIAIKGPLTTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPL--KNP 148 Query: 125 GDIDFYVVRENTEGEYSSL---GGRVNEGTEHEVVIQESVFTR----------------R 165 + V+R+++E YS + G V + + +E TR Sbjct: 149 YLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISKE 208 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NYPEI-----RWD 219 G +R++RYA A ++LT K N L + + A+A+ Y I RW Sbjct: 209 GSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQAIDDENGRW- 267 Query: 220 KQHI---------------DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIA 264 HI D + + +M PE+FDVV +N GD L+D+ A G +GI Sbjct: 268 -LHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADMLSAQVGGVGIM 326 Query: 265 PSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 P+ANLN E F FEP HG+ I G+N ANP ++I + +ML F+ ++ +A N Sbjct: 327 PAANLNNEVAF---FEPTHGTFARIAGQNKANPSSSILSAVLMLKFM-----QWHEAANL 378 Query: 325 ILAAIEEVIAHGPKTPDM 342 I A+E +A G T D+ Sbjct: 379 IENALERTLAAGEVTFDL 396 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 125 bits (315), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 92/254 (36%), Positives = 125/254 (49%), Gaps = 17/254 (6%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG E++ + VL+AAA R L F E A + + G M E++ Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTS-EDAGADAFRRTGSAMSAATLERI 66 Query: 67 -SRFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +R+ + G VG P PD R D Y N+RP+ L PGV PL G Sbjct: 67 RTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTA- 125 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR- 183 +D+ +VRENTEG Y S G V + + TR GV+R++ +AFELA R Sbjct: 126 --VDYVIVRENTEGLYLSRGRGVGN---DRACADQLLMTRHGVERVVVHAFELATRRTGA 180 Query: 184 -----KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + +T KSN L S ++ E + +A YP++ D ++ D V P RFD Sbjct: 181 PADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRFD 239 Query: 239 VVVASNLFGDILSD 252 V+V N GDILSD Sbjct: 240 VLVMENFLGDILSD 253 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 125 bits (313), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 96/358 (26%), Positives = 167/358 (46%), Gaps = 34/358 (9%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + + G GIG E++ +RVL+AA G LS+E +S + + +D+ E L Sbjct: 40 VTILTGSGIGPEIMDHTLRVLKAA----GAPLSYEIFALSSKDGSKN------NDFDEAL 89 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + G + + + + FR+ D +V + + FPG+ + G+ Sbjct: 90 TSIRRNRVALKGNIELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGL-----SNKFGE 144 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFELAQSRP 182 ID V+R+NTEGEY L EHE V V TR ++R++ +AF+ A + Sbjct: 145 IDITVIRQNTEGEYLML--------EHEPRTGSVESLKVLTRFNLERLIEFAFDYALTND 196 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T +N ++ + ++++YP I+ + +++ + P FDV++A Sbjct: 197 RKLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVILA 256 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +NL G ++S+ G G+ N + + ++FEP I G N ANPIA I Sbjct: 257 TNLNGSMISNYLNGMLGGPGLTSGINFSADGI--AVFEPGARNKGSSIVGLNRANPIAMI 314 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +G +L LG ++ + HN + A + + +TPD+ G AT + D I + I Sbjct: 315 MSGINLLHHLGY-NKTAEMIHNSVYATL---VYDKIRTPDIGGQATAEETVDHIIRHI 368 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 124 bits (312), Expect = 4e-27, Method: Composition-based stats. Identities = 67/123 (54%), Positives = 82/123 (66%), Gaps = 12/123 (9%) Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI---AT 300 N+FGDILSDLGPACTGTI +APS ++NPE FPSLFEPVHGS PDI+GK IANPI A Sbjct: 3 NVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQMAR 62 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG----PKTPDMKGNATTPQVADAIC 356 GAM+LD LG + + I + IE+V++ G P TPD+ G+A T + AI Sbjct: 63 FGVGAMILDHLG-----YPETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKAIA 117 Query: 357 KII 359 I Sbjct: 118 AAI 120 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 124 bits (311), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 97/298 (32%), Positives = 145/298 (48%), Gaps = 39/298 (13%) Query: 91 GSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGG----- 145 ++L+ R+ FD Y+NLRP + P + PL G ID + RENTE YS++ Sbjct: 103 SAILQMRQLFDLYINLRPAKTLPDLGSPLKGDPK--IDLVLFRENTEDLYSAVEFHPLPE 160 Query: 146 ---RVNEGTEH-----EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 +++G E +V + VF+ G +RI+R AFE A+S R + K+N + Sbjct: 161 EMFNLHKGMERFRKMGDVAVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRE 220 Query: 198 SMPYWDERVEAMAENYPE--IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 + +A+ Y + I +++ D + P+ + V+V SN+FGDILSD Sbjct: 221 TDGMMKRIFLEVAKEYEQYGITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSDEAS 280 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 TG +G APS N+ E T ++FEP GS P + NP A + MML++LG Sbjct: 281 QLTGGLGFAPSGNIG-ENT--AIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLG--- 334 Query: 316 ERFQQAHNGILAAIEEVIAHG-PKT------------PDMKGN-ATTPQVADAICKII 359 QA I AI EV+ PKT PD + N A+T ++A AI + I Sbjct: 335 --LDQAGQKIEWAINEVLKENRPKTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 122 bits (306), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 100/363 (27%), Positives = 168/363 (46%), Gaps = 51/363 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHH----GKMMPDDW 62 + +PGDG+G E++ V +AAA E+ HH M ++ Sbjct: 51 VTMLPGDGVGPELMHAVKEVFKAAA--------------VPVEFQEHHLSEVQNMASEEK 96 Query: 63 HEQ-LSRFDAIYFGAVGWPDTVPDHISLWGSL-LKFRREFDQYVNLRPVRLFPGVPCPLA 120 EQ LS +G T ++ S ++ RR+ D + N+ V+ PG Sbjct: 97 LEQVLSSMKENKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT--- 153 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESVFTRRGVDRILRYAFE 176 + ++D ++RE TEGEYSSL EHE V+ + TR RI ++AF+ Sbjct: 154 --RHNNLDLVIIREQTEGEYSSL--------EHESARGVIECLKIVTRAKSQRIAKFAFD 203 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 A + R +T+ K+N + + + + E +AE YP+I+++ ID C + V P + Sbjct: 204 YATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQ 263 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE--PVHGSAPDIYGKNI 294 FDV+V NL+G+I+ +L G G+ P + + E ++FE H A + G+NI Sbjct: 264 FDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY---AVFETGARHPFAQAV-GRNI 319 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGIL--AAIEEVIAHGPKTPDMKGNATTPQVA 352 ANP A + + + ML L + H+ ++ A + + +T DM G +TT Sbjct: 320 ANPTAMLLSASNMLRHLN------LEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFI 373 Query: 353 DAI 355 ++ Sbjct: 374 KSV 376 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 122 bits (305), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 99/353 (28%), Positives = 164/353 (46%), Gaps = 30/353 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG GIG PE +R ++A FA +++ + ++ G D + Sbjct: 50 VTLLPGHGIG----PEMMRHVEAI-----FACGKVPVDFETIIVDANVGDASSMDHAIKS 100 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + + G +T +++ L R + + YVN+ R PG+ G Sbjct: 101 IRRNGVALK--GNIETTSYSMTVEPRNLLLRNKLELYVNVVHCRNHPGINTKHKG----- 153 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 +D V+R+NTEGEYS L V G VV + T +I +Y FE A++ RK + Sbjct: 154 VDIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYCFEYARTHMRKKV 209 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T K+N + ++ + + +A+ YP+I + ID C + V P +FDV++ NL+ Sbjct: 210 TVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDVMLVPNLY 269 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIWAGA 305 G+I+ ++ G G+ N E ++FE + + GKN+ANP+AT++A Sbjct: 270 GNIVVNVACGLVGGAGVTSGRNYGKEY---AVFETATRNTGTPLVGKNLANPVATLYAAV 326 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICK 357 ML L D I AIE+ + T D+ G+ATT +V + I K Sbjct: 327 DMLKHLELWDHAVV-----IRRAIEKTVNRDKVHTKDLGGDATTSKVVENILK 374 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 121 bits (303), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 114/392 (29%), Positives = 165/392 (42%), Gaps = 67/392 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW----ASCEYYSHHGKMMPDDW 62 I I GDGIG E+ V AA ++ +Q+ W A Y G+ +PD Sbjct: 21 IPFIEGDGIGPEIWKAAKTVFDAAVKK--AYDGQKQVNWLPLLAGETAYKKTGQWLPDKT 78 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 L Y + P T P I + R++ D Y RPV +PG P P+ Sbjct: 79 LATLRE----YLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPVV-- 132 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE----VVIQESV---------------FT 163 P +++ V RENTE Y+ + V+ E + Q+ + + Sbjct: 133 HPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIKPIS 192 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSN------------GLAISMPYWD-------- 203 ++G R++ A + A + R TLT K N G + Y D Sbjct: 193 KQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDKVFTWNQY 252 Query: 204 -----ERVEAMAENYPEIRWDKQHI---DILCARFVMQ----PERFDVVVASNLFGDILS 251 ++ E A+ + D+Q + D++ F Q PE F+VV NL GD +S Sbjct: 253 NQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATMNLNGDYIS 312 Query: 252 DLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFL 311 D A G IGIAP N+N +T ++FE HG+AP G+N NP + I +GAMM D+L Sbjct: 313 DALAAQVGGIGIAPGGNIN-YQTGHAIFEATHGTAPQFAGQNKLNPTSIILSGAMMFDYL 371 Query: 312 GNGDERFQQAHNGILAAIE--EVIAHGPKTPD 341 G D+ GI AI+ V KTPD Sbjct: 372 G-WDDVSNLIRIGIKRAIKSHHVTVDFAKTPD 402 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 117 bits (294), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 101/361 (27%), Positives = 167/361 (46%), Gaps = 40/361 (11%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD-DWHEQ 65 + +PGDGIG PE + ++Q + FE+ + S P+ D Sbjct: 47 VTLLPGDGIG----PEMLDIVQKIFTFANVPVDFEECQLDS-------KPTSPESDLDNA 95 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + G +T D ++ RR D + N+ P +P G Sbjct: 96 IMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPTRHKG---- 151 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVV--IQES--VFTRRGVDRILRYAFELAQSR 181 I+ ++RENTEGEYS G EHE V + ES + TR ++RI R+AF+ A + Sbjct: 152 -INIVMIRENTEGEYS--------GHEHETVNGVVESLKICTREKLERISRFAFDYAIAH 202 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAEN-YPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T+ K+N ++ + + V +AE YP I +D +D + V +P++FD++ Sbjct: 203 NRKKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQFDIM 262 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIA 299 + NL+G+I+S++ G G+ N+ + ++FE + I G++IANP A Sbjct: 263 LMPNLYGNIISNIACGLVGGPGLVSGMNIGDKY---AVFETGTRNTGSGIAGQDIANPTA 319 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAI-EEVIAHGPKTPDMKGNATTPQVADAICKI 358 I AG ML +LG + N I A+ + ++ T D+ G A T V +A+ + Sbjct: 320 FIRAGVDMLHYLG-----LTEYANLISDALFDAIVIKRLHTKDIGGTAKTSDVVNAVMRN 374 Query: 359 I 359 I Sbjct: 375 I 375 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 117 bits (294), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 105/365 (28%), Positives = 165/365 (45%), Gaps = 56/365 (15%) Query: 10 IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM---PDDWHEQL 66 I GDGIG ++ P I+V+ AA E+ A E+ + A E Y+ D W Q Sbjct: 34 IEGDGIGVDISPVMIKVVDAAVEK---AYKGER-KIAWMEVYAGEKATQVYDQDTWLPQ- 88 Query: 67 SRFDAI--YFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 DA+ Y ++ P T P + + R++ D YV RPVR F GVP P+ K+P Sbjct: 89 ETLDAVRDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPV--KKP 146 Query: 125 GDIDFYVVRENTEGEYSSL--------GGRVNEGTEHEVVIQESVFT-----------RR 165 GD+D + REN+E Y+ + +V + E+ +++ FT + Sbjct: 147 GDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPVSQE 206 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAIS---MPYW------DERVEAMAENYPEI 216 G R++R A + A R ++T K N + + W DE + + P + Sbjct: 207 GTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELLDGGPWM 266 Query: 217 RWDKQHI-----------DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 ++ D + + +++P +DV+ NL GD LSD A G IGIAP Sbjct: 267 QFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGGIGIAP 326 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG--NGDERFQQAHN 323 ANL+ ++FE HG+AP G++ NP + I + MML +G + + N Sbjct: 327 GANLSDS---VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRHMGWTEAADLIIKGTN 383 Query: 324 GILAA 328 G +AA Sbjct: 384 GAIAA 388 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 117 bits (293), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 75/220 (34%), Positives = 109/220 (49%), Gaps = 19/220 (8%) Query: 96 FRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE- 154 R D Y N+ + PGV + DID +VRENTEGEYSSL EHE Sbjct: 51 LRTSLDLYANVIHWKSLPGVVT-----RHKDIDILIVRENTEGEYSSL--------EHES 97 Query: 155 ---VVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 VV + T+ RI YAF+LAQ RK +T+ K+N + + + + +A Sbjct: 98 VAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAA 157 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP+I ++ +D + V +P++FDV+V NL+G+I++++ G G+ AN Sbjct: 158 RYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG- 216 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFL 311 + + I KNIANP AT+ A MMLD L Sbjct: 217 -HVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHL 255 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 98/347 (28%), Positives = 149/347 (42%), Gaps = 23/347 (6%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG+G+G EV+ + +L+ E G FE + ++ ++ Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATG--QRFEVRTGGPIGRQAE--RLTGRGLTPEV 85 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP-----GVPCPLAG 121 F A F G P + RR FD Y L P+R +P GV P A Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAA 142 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +VREN G Y G EG Q + V+RILR A LA R Sbjct: 143 RSA---DVLIVRENASGLYCGEWGSEGEGAARSA-YQVCRYRADEVERILRTALRLAGQR 198 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L TK G+ W + + A+A + +R +D + + P +FDV+V Sbjct: 199 -RGDLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIV 257 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 N+FGDIL D G G+ G++ S N ++++ HG+A D+ G++ ANPI + Sbjct: 258 CPNMFGDILGDCGSLLMGSRGMSWSGNYGA--AGQAVYQTAHGAAWDLAGRDRANPIGQV 315 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 + AMML R + + AI +A G +T D++G T Sbjct: 316 CSLAMML----RESFRLPALADALETAIARTLARGVRTADIQGAQPT 358 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 115 bits (288), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 109/406 (26%), Positives = 169/406 (41%), Gaps = 65/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH-HGKMMPDDWHE 64 I I GDGIG EV I+V A E+ +G + E E G +PD E Sbjct: 47 IGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLPDQSIE 106 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L + ++ A P P + R+ FD Y N+RPV+ FPG+P PL ++P Sbjct: 107 VLRKI-RVFLKA---PLETPVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPL--RRP 160 Query: 125 GDIDFYVVRENTEGEYSSL--------GGRVNEGTEHE--VVIQESV------FTRRGVD 168 +D + RENTE Y+ + ++ E E V I++ ++ G Sbjct: 161 ELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPISKFGTQ 220 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY--------------- 213 RI R A + A R+ +T K N + + E +A N Sbjct: 221 RIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFEDELAQYG 280 Query: 214 -----PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN 268 ++ + + D + + + + +DV++A NL GD +SD G +G+AP + Sbjct: 281 GSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLGVAPGLD 340 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + + + EPVHG+AP GKN NP ATI A +M FLG +++ I+ Sbjct: 341 VG---DWGMMAEPVHGTAPKYRGKNYVNPTATILALELMFRFLG-----WREVAEYIMKG 392 Query: 329 IEEVIAHGPKTPDMKGNAT-------------TPQVADAICKIILR 361 +E G T D+ T T + AD + +II R Sbjct: 393 VETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIKR 438 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 112 bits (280), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 27/253 (10%) Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 P +VP + ++ FRR+ + ++RPV PG+P G +DF + RE TE Sbjct: 83 PSSVPTNYNVA-----FRRQLGLFASMRPVHNLPGIPSRFTG-----VDFLLFREITEDL 132 Query: 140 YSSLGGRVNEGTEHEVV---IQE-SVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 Y++ +EHE+V +Q + T R + AF+ A+ R RKT+ K+N L Sbjct: 133 YTA--------SEHEIVPGVVQSFKIVTEAACLRFFKLAFDTARKRGRKTVHCIHKANIL 184 Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 ++ + E +A+ YPEI +D C + V +P++F+V+ A NL+GD+LSDLG Sbjct: 185 KMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLSDLGA 244 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 G G++ +A +N + +++E V+G++ + +++NP+ I +L LG Sbjct: 245 GLVG--GVSTTAAIN-KGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLKDLGETG 301 Query: 316 E--RFQQAHNGIL 326 R Q+A +L Sbjct: 302 TAGRIQKAVETVL 314 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 110 bits (274), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 97/372 (26%), Positives = 163/372 (43%), Gaps = 47/372 (12%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFAL-SFEQMEWASCEYYSHHGKMMPDD 61 K ++ + GD IG EV+ E + + +G + +FE++ SC H + + Sbjct: 11 KAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSC--LDQHDCPIQES 68 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ S A+ G+VG P D +L+ R+ + Y N+RP ++ L Sbjct: 69 TLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 120 AGKQPG---DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRIL--RYA 174 + + ++ +REN G Y F R+ L + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIY---------------------FGRKQEPDPLAHKAA 167 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI--RWDKQHIDILCARFVM 232 LA S + S K+N +A S + E + + +P++ + Q +D Sbjct: 168 LSLASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAK 227 Query: 233 QPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN----PERTFP---SLFEPVHG 284 P + + VV+ NLFGDILSDL G++G+ SA ++ P + F +++PV G Sbjct: 228 DPRKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSG 287 Query: 285 SAPDIYGKNIANPIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 SAPDI GK IANPI + +M + LG +A + I +AI++ + G T D+ Sbjct: 288 SAPDIAGKGIANPIGMFMSFGLMCRWSLG-----LPKAADAIDSAIKDCLESGQCTRDVG 342 Query: 344 GNATTPQVADAI 355 G +T Q A+ Sbjct: 343 GTLSTQQAGSAL 354 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 110 bits (274), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 94/358 (26%), Positives = 151/358 (42%), Gaps = 30/358 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M I + GDGI +E+ + + A+ F + F ++ S E G + D+ Sbjct: 6 MNRYSIVELHGDGIARELS----QAVHTVADALPFEIEFIPVDL-SDESREAKGDAIYDE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + R+ P+ + R + V RPV PG+ Sbjct: 61 AEAAMRRYGTSLKYPTATTKESPNRV--------LRERCNFAVIHRPVATIPGIQTHYNE 112 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + I +VR T G Y G R+N T + RR R+AF LAQ R Sbjct: 113 R----IHLDIVRIATGGTYEDAGRRINRDT----AVSIRAIERRPSVLASRFAFRLAQLR 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + ++ + A + E +A +YP + ++ D L A +M+PER+ V+V Sbjct: 165 DSNVIATSKYTIQKATD-GLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPE---RTFPSLFEPVHGSAPDIYGKNIANPI 298 N +GD LSD+ G+IG+ SA+ + + + ++F+P G+APDI G+N ANP Sbjct: 224 CPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPT 283 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A + A A ML +G D + + A+ I G KT D+ G+ + I Sbjct: 284 AALLAMANMLRHIGEHD-----SSKALRGALFGAIEAGEKTADIGGSLNLSEFTQVIV 336 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 108 bits (271), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 113/218 (51%), Gaps = 13/218 (5%) Query: 92 SLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT 151 L K R++F + + R G + G +D ++R+ EGEYS + RV G Sbjct: 58 CLRKLRKKFQLFAFVAVCRNLEG-----QNTRYGKLDCLIIRDQVEGEYSGIEHRVVPGV 112 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + V T G DR+ RY FE A+ RK +T A K+N + ++ + + A Sbjct: 113 MQTI----KVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLTDGTFLSPMRREAA 168 Query: 212 NYPE-IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN 270 Y + I ++++++D +C +M+PER DV+VAS+++GD+L+ + + G + P + Sbjct: 169 KYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASIMGGPALCPGFAVG 228 Query: 271 PERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML 308 P ++EP+ + +I GK+I NP + +G +ML Sbjct: 229 P---MGLIYEPIIHTNTNIAGKDIVNPTGMLLSGVLML 263 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 108 bits (269), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 97/352 (27%), Positives = 150/352 (42%), Gaps = 58/352 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKM------MP 59 I I GDGIG +V P ++V+ AA A+ +G ++EW KM +P Sbjct: 29 IPYIEGDGIGVDVTPPMLKVVNAAVAKAYG---GDRKIEWLEVYAGEKATKMYDSETWLP 85 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ L + ++ P T P + + R+ D YV RPV+ F GVP P+ Sbjct: 86 EETLNILQEYKV----SIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPV 141 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV---IQE----------------S 160 K+P ++D + RENTE Y+ + + V+ I+E Sbjct: 142 --KRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIK 199 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM-PYWDERVEAMAENY------ 213 ++ G R++R A + A + ++T K N + + + D E E + Sbjct: 200 PVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLLH 259 Query: 214 -------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGT 260 EI D + + +++P + V+ NL GD LSD A G Sbjct: 260 GGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQVGG 319 Query: 261 IGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 IGIAP ANL E ++FE HG+AP GKN NP + I + MML +G Sbjct: 320 IGIAPGANLGDEV---AVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMG 368 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 107 bits (267), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 106/385 (27%), Positives = 165/385 (42%), Gaps = 76/385 (19%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER---------WGFALSFEQMEWASCEYYSHHGKM 57 I I GDGIG E+ + ++ A E+ W L+ ++ E G+ Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAE-------EKTGER 93 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVR-LFPGVP 116 +P + + L G +G P V + S L RR FD Y +RPV + P Sbjct: 94 LPQETLDVLKESIVGIKGPLGTP--VGKGVRSINSAL--RRAFDYYSAVRPVYWMGQATP 149 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSL--------GGRVNEGTEHEVVIQESVF------ 162 P P +D V RENT+ Y+ + +V E E+ +E F Sbjct: 150 IP----NPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGI 205 Query: 163 ---------TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM-------------P 200 T+R V + LRYA E +K + K N + + P Sbjct: 206 TVKPMSEFKTKRHVRKALRYALE----NNKKNVAVIGKGNIMKATEGAFINWAFEVAEEP 261 Query: 201 YWDERVEAMAENYP---EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + +V E P +++ K D + + V++PE +DV++A NL GD +SDL + Sbjct: 262 EFKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASL 321 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDER 317 G G PS N+ +LFE HG+A DI GK IANP++ +GAMML+++G Sbjct: 322 IGGPGFVPSGNIGDGY---ALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIG----- 373 Query: 318 FQQAHNGILAAIEEVIAHGPKTPDM 342 +++A + A+ +A TPD+ Sbjct: 374 WKEAAQKVYDAVRRTLAEHIGTPDI 398 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 107 bits (266), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 96/318 (30%), Positives = 146/318 (45%), Gaps = 27/318 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDG+G E+ E + L+ A E +G + F + A +P + + Sbjct: 16 IALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEA-IAGTAALDRGQCPLPRESLKTC 74 Query: 67 SRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAGK 122 D+I G AVG + L R ++RP + CPL + Sbjct: 75 LEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELCPLKEE 134 Query: 123 -QPGDIDFYVVRE------NTEGEYSSLGG-RVNEGTEH--EVVIQESVFTRRGVDRILR 172 + +D ++R+ TEG+ S+L R TE E +I++S R Sbjct: 135 IRKKGMDILIIRDIAGGMFTTEGKSSNLCNVRAAWDTESYDETLIRDSA----------R 184 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 AF+LA SR RK +TS K+ L+ S+ W + +E +YPEI + +D + V Sbjct: 185 LAFQLAASRKRK-VTSLDKAILLSSSV-LWRQILEETHRDYPEIELEHMLVDHGAFKLVS 242 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P+ FDV+VASN+FGDI++D TG P+ +LN ER +H ++ G Sbjct: 243 SPDAFDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGT 302 Query: 293 NIANPIATIWAGAMMLDF 310 ANP+ I A AMML++ Sbjct: 303 GRANPVGMILAAAMMLEY 320 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 106 bits (265), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 99/386 (25%), Positives = 169/386 (43%), Gaps = 67/386 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER---------WGFALSFEQMEWASC-EYYSHHGK 56 I I GDGIG ++ P I+V+ +A ++ W +E C + + H + Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAW-----YEVFVGEKCYQKFKDHKE 86 Query: 57 MMPDDWHEQLSRFDAI--YFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + P++ +AI Y ++ P T P + R++ D YV LRPVR + G Sbjct: 87 LSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWY-G 145 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSL--------GGRVNEGTEHEVVIQESVF---- 162 P P+ K+P +D + REN+E Y+ + ++ ++E+ +++ F Sbjct: 146 SPSPV--KEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESS 203 Query: 163 -------TRRGVDRILRYAFELAQSRPRKTLTSATKSN------------GLAISMPYWD 203 ++ G +R++R A E A + ++T K N G A++ ++ Sbjct: 204 GVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263 Query: 204 ERVEAMA--------ENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 +V + EI D + +++P + V+ NL GD +SD Sbjct: 264 AQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 A G IGIAP ANLN +FE HG+AP G + NP + I + MML +G Sbjct: 324 AMVGGIGIAPGANLNDTV---GMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMG--- 377 Query: 316 ERFQQAHNGILAAIEEVIAHGPKTPD 341 + +A + I++A+E+ I T D Sbjct: 378 --WVEAADLIVSAMEKAIKSKKVTYD 401 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 105 bits (263), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 85/273 (31%), Positives = 131/273 (47%), Gaps = 26/273 (9%) Query: 99 EFDQYVNLRPVR----LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE 154 ++ Y ++ PV+ L P V P D+D VVRENTE EYS L +V G Sbjct: 163 KYGLYAHVVPVKAPQNLPPSVFTPFR-----DVDMVVVRENTEAEYSGLEHQVQPG---- 213 Query: 155 VVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP 214 VV + TR G RI ++AFE A+ R + + K+N + S + E + +A+ YP Sbjct: 214 VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEYP 273 Query: 215 EIRWDKQHIDILCARFVMQPERFD--VVVASNLFGDILSDLGPACTGTIGIAPSAN---L 269 +I++ + +D + V P FD VVV NL+G I+S+ + G +G+ N + Sbjct: 274 DIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNATDI 333 Query: 270 NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAI 329 N + A DI G+ IANPI I + MLD +G N I A+ Sbjct: 334 NKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMG-----MNTHANRIKFAL 388 Query: 330 EEVIAHG-PK--TPDMKGNATTPQVADAICKII 359 +E + + PK TPD+ G ++ +A+ + I Sbjct: 389 KETLLNANPKILTPDIGGTGSSVSFIEAMMRHI 421 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 105 bits (263), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 90/328 (27%), Positives = 152/328 (46%), Gaps = 33/328 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER--WGFALSFEQMEWASCEYYSHHGKMMP 59 + +++ +PGDGIG ++ + V + ++ + F ++ + E + K +P Sbjct: 35 LSHVKVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLP 94 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLK----FRREFDQYVNLRPVRLFPGV 115 E D + G P P W +LL RR+ Y +RP+R+ Sbjct: 95 PAVLEACKACDILVKG----PFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRI---- 146 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 P G ID+ REN EGEY + G ++ I + ++ G +R+ R AF Sbjct: 147 --PEKG-----IDWTFFRENIEGEY--IWGNKGICVGDDLAIDFKILSKPGAERLFRNAF 197 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+S + +T ATK+N + + + + AM + YP I ++ ID L A+ +M PE Sbjct: 198 EYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAK-LMDPE 256 Query: 236 ---RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 V V NL+GDIL+D+ G +G A S+N+ + ++FE +HG + Sbjct: 257 FNAGMQVFVLPNLYGDILTDIAAEYQGGLGTASSSNIGDQY---AMFEAIHGVGVYLVEH 313 Query: 293 N---IANPIATIWAGAMMLDFLGNGDER 317 N A+P + I A M+ F+G ++R Sbjct: 314 NRAQYADPSSLIRAMGEMMAFIGYPEKR 341 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 105 bits (261), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 56/152 (36%), Positives = 85/152 (55%), Gaps = 9/152 (5%) Query: 206 VEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 V MA+ +PEI+++++++D +C V P ++DV+V NL+GDILSD+ G +G+ P Sbjct: 122 VRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTP 181 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGI 325 S N+ +LFE VHG+APDI GK++ANP A + + MML + + I Sbjct: 182 SGNMGLN---GALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM-----ELNTYADKI 233 Query: 326 LAAIEEVIAHGPK-TPDMKGNATTPQVADAIC 356 A E I G T D+ G A + + IC Sbjct: 234 ERAAFETIKEGKYLTGDLGGRAKCSEFTNEIC 265 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 102 bits (253), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 76/259 (29%), Positives = 119/259 (45%), Gaps = 35/259 (13%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ I GDG G E+ RVL+A G A ++ ++ A + G +PD E Sbjct: 4 RVTLIRGDGTGPELAEATRRVLEAT----GVAFDWD-IQDAGVDVMEQLGTPLPDSVLES 58 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + A+ P T P + R+E D Y +RP R +PGV Sbjct: 59 IRSTKV----ALKAPITTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRFE----- 109 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR-------------------G 166 +ID VVRENTE Y+ G GT+ ++ + +R G Sbjct: 110 NIDLVVVRENTEDLYA--GIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPG 167 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +RI+R+AFE A++ RK +T+ K+N + S + E +A+ YP+I +D + +D + Sbjct: 168 SERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNM 227 Query: 227 CARFVMQPERFDVVVASNL 245 C + V +PE +DV+V NL Sbjct: 228 CMQLVQKPELYDVMVLPNL 246 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 101 bits (252), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 88/325 (27%), Positives = 150/325 (46%), Gaps = 29/325 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQ--AAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + +PGDGIG ++ + +RV + E + F + + E + +P + Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 63 HEQLSRFDAIYFGAVGWP---DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 E D + G P D P+ +S SLL RR Y +RPVR+ P Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVS-ANSLL--RRALQLYAAVRPVRI------PE 157 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G ID+ REN EGEY + G + ++ + V TR G +RI R AFE A+ Sbjct: 158 KG-----IDWTFFRENIEGEY--IWGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAK 210 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ--PERF 237 + + +T TK+N + + + + A+ + YP I ++ +D + A+ Q + Sbjct: 211 NNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKGM 270 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN---I 294 V + NL+GDI++D+ G +G A S+N+ + +LFE +HG + N Sbjct: 271 QVFLLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQY---ALFEAIHGVGNFLVQHNRAQY 327 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQ 319 A+P + I A M+ +G +++ Q Sbjct: 328 ADPCSLIRAMGEMISHIGYPEKKEQ 352 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 99.0 bits (245), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 137/291 (47%), Gaps = 49/291 (16%) Query: 76 AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVREN 135 AV P +PD+ + R + D YVNLRP + G+P ++D +VRE Sbjct: 62 AVIGPLMMPDNYRQMEA--DIREKLDLYVNLRPAKTMVGIPSNYQ-----NVDIMIVRET 114 Query: 136 TEGEYSSL--------------------GGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 TEG Y+ + G R+ E + + + +G +I+ +AF Sbjct: 115 TEGIYAGIEFERTSVEAADARSFLSKLSGKRIRE----DAAVGIKPISVKGCGQIIEFAF 170 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 A+ R + + +++ +A + + E +A+ +P+I + + I+++C + +PE Sbjct: 171 NYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPE 230 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIG--IAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 RFDV+V NL+GD+L+ L C G +G P A++ + ++F + D G Sbjct: 231 RFDVLVMPNLYGDLLAHL---CAGMVGGLSVPIAHVGDKY---AVF-GAQSTGTDDVGH- 282 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMK 343 +P + I AGA+ML LG Q+A + AA+E V+A H T D+ Sbjct: 283 --DPTSLILAGALMLRHLGE-----QEAAQRLQAAVEAVVASHVDTTADLN 326 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 99.0 bits (245), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 87/363 (23%), Positives = 165/363 (45%), Gaps = 45/363 (12%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 KT ++ I G+G+G+E++ V+ A +EW + + K D Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVK---------APIEWDVHDEFK--AKDSDDVS 133 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E L A G G D+ W + R++F Q+ + G+ P Sbjct: 134 PEVLKSLRANKVGIKGPVDS-----RHWQR--QIRKQFAQFAYVSLCSHIEGLDSPY--- 183 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV---VIQE-SVFTRRGVDRILRYAFELA 178 GD D ++R+ EG+YS G EH V V+Q V T G RI + F A Sbjct: 184 --GDFDVVIIRDQMEGDYS--------GIEHLVVPGVMQTIKVSTTAGAARIAEFVFNYA 233 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERF 237 RK +T A K+N + ++ + E + A A+ + ++ ++++++D + +++P + Sbjct: 234 VKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKC 293 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V+S+++GD+L + G GI P +++ + ++F+ + + GK++ANP Sbjct: 294 DVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANP 350 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAIC 356 + + A+ML + + + + + AI +V +TPD+ G A + A+C Sbjct: 351 TGPLLSAALMLRHV-----KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVC 405 Query: 357 KII 359 + Sbjct: 406 DCL 408 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 96.7 bits (239), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 63/267 (23%), Positives = 130/267 (48%), Gaps = 19/267 (7%) Query: 95 KFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHE 154 + R++F Q+ + G+ P GD D ++R+ EG+YS + V G Sbjct: 58 QIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGDYSGIEHLVVPGVMQT 112 Query: 155 VVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY- 213 + V T G RI + F A RK +T A K+N + ++ + E + A A+ + Sbjct: 113 I----KVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHV 168 Query: 214 PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPER 273 ++ ++++++D + +++P + DV+V+S+++GD+L + G GI P +++ Sbjct: 169 DDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVS--- 225 Query: 274 TFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI 333 + ++F+ + + GK++ANP + + A+ML + + + + + AI +V Sbjct: 226 SLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHV-----KMDKQADQVDCAIRKVY 280 Query: 334 AHGP-KTPDMKGNATTPQVADAICKII 359 +TPD+ G A + A+C + Sbjct: 281 KDTDIRTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 94.7 bits (234), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 107/365 (29%), Positives = 147/365 (40%), Gaps = 49/365 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQA----AAERWGFALSFEQMEWASCEYYSHHGKM 57 M T I GD G EV+ E ++VL+A + F L + AS + H Sbjct: 1 MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKV---HNDP 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDH-ISLWGSLLKFRREFDQYVNLRPVRLFPGV- 115 + DAI GA+G P+ P + LL+ R+E Y NLRP Sbjct: 58 LTAKALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSL 117 Query: 116 --PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 PL DF VVRE T G Y G R E + ++R ++RI R Sbjct: 118 VDSSPLKADVCRGTDFIVVRELTGGIY--FGAR-TEDDGSGFAMDTDAYSRAEIERIARL 174 Query: 174 AFELA-QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 A LA + P + S K+N LA S + E A +P++ Q ID V Sbjct: 175 AGFLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVK 234 Query: 233 QPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 P + VVV SNLFGDI+SD G+I G Sbjct: 235 SPRALNGVVVTSNLFGDIISDEASVIPGSI-----------------------------G 265 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 I NPI TI + AMML + N + + A++ +G +T D+ G+A T Q+ Sbjct: 266 AGIVNPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTALD----NGTRTKDLGGSAGTFQM 321 Query: 352 ADAIC 356 ADA+ Sbjct: 322 ADAVV 326 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 94.4 bits (233), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 44/81 (54%), Positives = 57/81 (70%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + RIA IPGDGIGKE +PE +RV AAA R+GFAL ++AS + + HGK+ PDD Sbjct: 1 MSSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDD 60 Query: 62 WHEQLSRFDAIYFGAVGWPDT 82 + L +DA++FGAVG PDT Sbjct: 61 RFDTLRGYDALFFGAVGRPDT 81 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 94.0 bits (232), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 101/364 (27%), Positives = 157/364 (43%), Gaps = 37/364 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWH 63 +R+A +PGDG+G+EVL R+L+ AER ++ W + G ++P Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTG---PWPVGARAAAETGDVLPAGTL 58 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWG--SLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 DAI GAVG VP + +L + R +D +++R + P A Sbjct: 59 AACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREI--------PFAD 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRV--NEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + + VVR G Y RV +G+E V++ TR V ++ A ++ Sbjct: 111 GR----ELTVVRNLIGGSYGGADDRVLREDGSEAADVLR---LTRERVAEVVHTACDVLG 163 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R L S K+N L + W + +A I + +++D DV Sbjct: 164 RRGGGRLVSVDKAN-LYATGRLWRQVAGDVARER-GIEVEHRYVDRAAFELGSGAPVPDV 221 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP----SLFEPVHGSAPDIYGKNIA 295 +V L GDILSDL G+ + SA+L+P LFEP HGSAP ++ Sbjct: 222 LVTEGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQV 281 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKT----PDMKGNATTPQV 351 +P+ A A +L ++A + AA+ V+ GP T P+ A+T QV Sbjct: 282 DPLGGFLALAALLRHF----PATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQV 337 Query: 352 ADAI 355 ADA+ Sbjct: 338 ADAV 341 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 95/370 (25%), Positives = 154/370 (41%), Gaps = 41/370 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAER-----WGFALSFE-------QMEWASCEYY 51 T I + GD G+E+L + +RVLQ + R + LS E ++ W + + Sbjct: 5 TPTIVVMHGDQTGEELLIQALRVLQPSVIRQPLQFLDYDLSLENRRATDNKVVWEAAQAA 64 Query: 52 SHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 G + + + G VG P+ + R + V LR R Sbjct: 65 RDSGLSL------KAATITPEIAGDVGSPNAI------------LREALNAKVILRTGRR 106 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRIL 171 P + P+AG +VR + Y S R E+ + S +R + Sbjct: 107 IPKI-RPIAGVYS---PIAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVA 162 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 + F+ A+ R + + K A + E ++A A+ YPE+ + ID A + Sbjct: 163 EFTFQYAK-RTKAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLL 221 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE----RTFPSLFEPVHGSAP 287 V+ A N GD+LSD+ G+I + S L E + + E HG+AP Sbjct: 222 QTTGESLVIPALNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAP 281 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 ++GKNIANP+A I AGA +L + + ++A I ++ E I G TPD+ G T Sbjct: 282 ALFGKNIANPMAMILAGAALLSY--GRIPQAEKASRAIYESVFETIYEGKATPDLGGQMT 339 Query: 348 TPQVADAICK 357 T + D + + Sbjct: 340 TSEFTDEVIR 349 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 92.4 bits (228), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 102/366 (27%), Positives = 161/366 (43%), Gaps = 19/366 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++I + GD G+E+L + +RVL E G L E+ + + + ++ D Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDLSLENRRATQNGVVSD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLK-FRREFDQYVNLRPVRLFPGVPCPL 119 + FG + P+ GS + R E D V +R R PGV P+ Sbjct: 59 ----AAAAMRTCGFG-IKAATITPEGADDVGSPNRILREEVDGKVIVRTGRRIPGV-TPI 112 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFELA 178 AG +VR E Y + R + G EV + TR + YAF A Sbjct: 113 AGVH---YPISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEYAFRTA 169 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++ + + K + E ++A A +P++ ++ ID A V Sbjct: 170 RAMQAR-VYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGAADEP 228 Query: 239 VVV-ASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNI 294 +VV A N GD LSDL G+I A S L + T ++ E HG+AP + GK++ Sbjct: 229 LVVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDV 288 Query: 295 ANPIATIWA-GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVAD 353 ANP+A + A GA++ G ++A I ++ E IA G KTPD+ G+A T + D Sbjct: 289 ANPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTD 348 Query: 354 AICKII 359 A+ + I Sbjct: 349 AVIERI 354 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 91.3 bits (225), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 104/377 (27%), Positives = 162/377 (42%), Gaps = 57/377 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW---ASCEYYSHHGKMMPDDWH 63 +A GDGIG E++ +VL AA ++ + + + W A E G ++PD Sbjct: 35 VAYFKGDGIGPEIVESAKKVLDAAVDK-AYGGTRRIVWWEVTAGEEAQKECGSLLPDG-- 91 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 L F G P T P + R D Y N+RPV+ + G P P Sbjct: 92 -TLQAFKLARVNLKG-PLTTPVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTPHC--H 146 Query: 124 PGDIDFYVVRENTEGEYSSL--------GGRVNEGTEHEVVIQESVFTRRGV-------- 167 P +ID+ + RENTE Y+ + ++ + + E I+ + T G+ Sbjct: 147 PENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPISKWRT 206 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLA-------------ISMPYWDERV--EAMAEN 212 R +R A E A K +T K N + I + D V E + Sbjct: 207 QRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEEVNTK 266 Query: 213 Y----PE--IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y PE I + + D + + + +P ++V+V NL GD +SD A G IG+A Sbjct: 267 YGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIGMAAG 326 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGI 325 ++ ++ EPVHGSAP GKN+ NP A I +G +L DF+G + + + Sbjct: 327 LDMG---DGIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKLLVEY--- 380 Query: 326 LAAIEEVIAHGPKTPDM 342 A+++ IAH T D+ Sbjct: 381 --AVKQAIAHKQVTYDL 395 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 89.4 bits (220), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 93/370 (25%), Positives = 153/370 (41%), Gaps = 44/370 (11%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW--ASCEYYSHHGKMMPDDW 62 +R+ I G G G VL AA R F + +EW + Y H K Sbjct: 41 IRVTVIEGQGTGPVVL---------AAVRKIFKAALVPVEWDYQTLSVYRDH-KTNRMTV 90 Query: 63 HEQLSRFDAIYFGAV-GWPDTVP-DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + QL AI G V D+ P + SL L + + +V +R + Sbjct: 91 NPQLLD-SAIETGLVLCAKDSSPRQNDSLESDSLALHKALNAFVGVRKFN-------SVV 142 Query: 121 GKQP-GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +P G I+ +RE+ GEYS + V+ G VV +++ + + AF+ A Sbjct: 143 GHEPYGPINLVNIREHVSGEYSEIEHLVSPG----VVQSIKTVSKKISVEVAKLAFDYAC 198 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 +T K++ + +S + + ++ YP++ ++++ +D C P R++V Sbjct: 199 KHGHSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRYEV 258 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV------HGSAPDIYGK- 292 ++ ++L+G + +G + P+ P+ T S H I+ K Sbjct: 259 LLTTSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKM 318 Query: 293 -----NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 I NP I A A+MLD G A I AA+E+ I G +T DM G+A+ Sbjct: 319 VYGQEQIINPTGIIRAAALMLDHAG-----MVVAGRCIAAAVEDTIRQGIRTQDMGGDAS 373 Query: 348 TPQVADAICK 357 Q DAI K Sbjct: 374 CSQFTDAIIK 383 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 82.0 bits (201), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 47/128 (36%), Positives = 66/128 (51%), Gaps = 6/128 (4%) Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P +FDV+V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGV--AIFESVHGTAPDI 87 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 GK++ANP A + + MML +G A A + + T D+ GN Sbjct: 88 AGKDMANPTALLLSAVMMLRHMG----LHGHAKKIETACFDTIRDKKVLTKDLGGNPKCS 143 Query: 350 QVADAICK 357 + IC+ Sbjct: 144 EFTADICR 151 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 70.5 bits (171), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 48/137 (35%), Positives = 71/137 (51%), Gaps = 8/137 (5%) Query: 10 IPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSR 68 I GDGIG ++ P I+V+ AA ++ +G ME + E + D W Q Sbjct: 34 IEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQ--DTWLPQ-ET 90 Query: 69 FDAI--YFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 DA+ Y ++ P T P + + R++ D YV LRPVR F GVP P+ K+PGD Sbjct: 91 LDAVKDYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPV--KKPGD 148 Query: 127 IDFYVVRENTEGEYSSL 143 +D + REN+E Y+ + Sbjct: 149 VDMTIFRENSEDIYAGI 165 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 69.3 bits (168), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 87/359 (24%), Positives = 146/359 (40%), Gaps = 31/359 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + ++A +PGDG G + R L R + + ++ + G +P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + DA+ G P I LL R+E + VN+RPVR + Sbjct: 68 TLGACRQSDAVLVCGCGDPRY---GIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 122 KQPG---DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 +P +D R+ T G Y GR E + + ++R+ ++RI R A A Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYY---GRRKEAGDDGEAYDTTPYSRQTIERIARLAGTYA 181 Query: 179 -QSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN-YPEIRWDKQHIDILCARFVMQPER 236 Q P K + S K N +A S W V + EN +P++ +H+ + A ++ + Sbjct: 182 MQFSPPKPVHSIDKHNVMATSR-LWRSVVAHVFENEFPQVPL--RHVLVDTASMILSSDP 238 Query: 237 FD---VVVASNLFGDILSDLGPACTGTIGIAPSANLNP-----ERTFPSLFEPVHGSAPD 288 +++ N+FGDILSD G+ + SA ++ R P +FEP + + Sbjct: 239 LSLNGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNP-- 296 Query: 289 IYGKNIANPIATIWAGAMMLDF---LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG 344 G P+ +I A +ML+ L E +A L I E++ +T D+ G Sbjct: 297 --GGKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPI-ELVGSDTRTVDLGG 352 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 48/167 (28%), Positives = 76/167 (45%), Gaps = 16/167 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG E+ +++ AA + FE E A + Y G+++P+ +E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFE-TENAGSDVYEKTGELIPESLYES 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R A+ P T P + R+++D Y N R R PG+ + Sbjct: 58 VERNKI----AIKGPITTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIET-----RYD 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 +ID + RENTEG Y +G E E I T++G + +L+ Sbjct: 109 NIDLAIFRENTEGIY--IGEEKYENEEKTSAIAVKRITKKGSEELLK 153 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 65.1 bits (157), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 39/119 (32%), Positives = 62/119 (52%), Gaps = 8/119 (6%) Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D + + +P+ + ++ NL GD LSD A G +G+ P AN+ ++FE H Sbjct: 338 DSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGANIGDS---AAIFEATH 394 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 G+AP G + NP + I +G MML+F+G +Q+A + I I IA+ T D+ Sbjct: 395 GTAPKHAGLDRINPGSVILSGVMMLEFMG-----WQEAADLIKKGIGAAIANREVTYDL 448 Score = 58.9 bits (141), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 50/154 (32%), Positives = 71/154 (46%), Gaps = 20/154 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEW-------ASCEYYSHHGKMM 58 I I GDG G ++ P V+ AA A+ +G E++ W +CE Y + ++ Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYG---GREEINWFKVYAGDEACELYGTY-QIF 84 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P+D + + A+ P T P + + R+ FD Y +RP R +PG P P Sbjct: 85 PEDTLTAIKEYGV----AIKGPLTTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSP 140 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE 152 K P +D V RENTE Y LG EGTE Sbjct: 141 --HKTPEKLDIIVYRENTEDIY--LGIEWAEGTE 170 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 64.3 bits (155), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 38/119 (31%), Positives = 62/119 (52%), Gaps = 8/119 (6%) Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D + + +P+ + ++ NL GD LSD A G +G+ P AN+ ++FE H Sbjct: 338 DSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDS---CAIFEATH 394 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 G+AP G + NP + I +G MML+++G +Q+A + I + IA G T D+ Sbjct: 395 GTAPKHAGLDKINPGSVILSGVMMLEYMG-----WQEAADLIKRGLGASIADGKVTYDL 448 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/150 (28%), Positives = 65/150 (43%), Gaps = 18/150 (12%) Query: 10 IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-------ASCEYYSHHGKMMPDDW 62 I GDG G ++ P +VL AA + ++ W +C+ Y + + +P D Sbjct: 32 IRGDGTGIDIWPATEKVLDAAVAK--AYNGKRKISWFKVYAGDEACDLYGTY-QYLPQDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + A+ P T P + + R+ FD Y +RP R + G P P K Sbjct: 89 LTAIKEYGI----AIKGPLTTPIGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSP--HK 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTE 152 P +D V RENTE Y LG +G+E Sbjct: 143 SPDKLDVIVYRENTEDIY--LGIEWKQGSE 170 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 63.9 bits (154), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 63/267 (23%), Positives = 108/267 (40%), Gaps = 22/267 (8%) Query: 94 LKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH 153 LK + D YV + +R FPG C D+D V+ +N G YS L +G Sbjct: 135 LKICNDLDLYVFMTRLRSFPGFKCRFP-----DVDIQVIAQNNIGNYSELEYAPVKG--- 186 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 VV V T V + LR+AFE A R +T K+N ++ E E M AE+ Sbjct: 187 -VVEALRVVTHENVTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAED 245 Query: 213 YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 Y I+ + +D R + P FD + ++ + L+ + G + + L Sbjct: 246 YCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIELGDS 305 Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV 332 ++F+P+ + + ++ +P + +L+ +G + + + Sbjct: 306 H---AVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQ-----ESCAKSLWKGMLRT 356 Query: 333 IAHGPKTPDMKGNATTPQVADAICKII 359 + G KT + G T V IC I+ Sbjct: 357 MTDGIKTVEFDGPDTGEYV---ICNIM 380 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 42/132 (31%), Positives = 64/132 (48%), Gaps = 12/132 (9%) Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + P R + A NL GDI SD+ A G++ A S + ++ LFE HG+A D Sbjct: 430 KMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASS--IIESKSSTMLFEAPHGTAHD 487 Query: 289 IYGKNIA--------NPIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPK 338 +Y K + NP A I+A A L+ LG +E + AA+++ + G Sbjct: 488 LYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYSARLKAALKDTVGDGIV 547 Query: 339 TPDMKGNATTPQ 350 T D+K TTP+ Sbjct: 548 TADLKDKTTTPE 559 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 58.9 bits (141), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 92/384 (23%), Positives = 152/384 (39%), Gaps = 68/384 (17%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++++ G+G G E+ RV+Q+ A R+ +++F + S Y+ + ++ + Sbjct: 1 MSSIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLR----SPRIYNSYSSLLAIN 56 Query: 62 -----WHEQLSRFDAIYF-----GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 E LS DA ++ AV S+ L RE Q + + L Sbjct: 57 DADAVTEETLS--DAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQAIKVEHFTL 114 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRIL 171 P L VR+ +G YS G + T + V + + F++ RIL Sbjct: 115 SPTSSILL------------VRDQAQGFYS---GTNSVNTSKDAVSRTAHFSKAIFARIL 159 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWD--------ERVEAMAENYPEIRWDKQHI 223 YA A L T S + +D E N ++ D + Sbjct: 160 SYALGRANQ-----LWGGTNSVTMVYKFHLFDGLFHTWATEWERTFGVNIRFVQGDTMNR 214 Query: 224 DILCARFVMQPERFDVVVASNLFGDILSD-------LG---PACTGTIGIAPSANLNPER 273 D+L +++++ N + DI+ LG AC A + L+P+ Sbjct: 215 DLLA----FGVSGHNLLISGNEYADIMQTILLDRFGLGAQESAC------AENVYLHPDV 264 Query: 274 TFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI 333 S ++ HGSA D+ GK I NP ATI A A +L+ G +Q + +L ++ Sbjct: 265 QGLSEYQTAHGSADDLLGKGIVNPTATIRAAAAVLEDQA-GCSGLKQRVDCVLG---DLG 320 Query: 334 AHGPKTPDMKGNATTPQVADAICK 357 A G TPD G ATT + +A + Sbjct: 321 ARGIGTPDQGGTATTERFVEAFLQ 344 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 58.2 bits (139), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 24/32 (75%), Positives = 28/32 (87%) Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMMLD 309 +FEP HGSAPDI G+NIANPIA IW+GA ML+ Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLE 32 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 58.2 bits (139), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 79/349 (22%), Positives = 143/349 (40%), Gaps = 49/349 (14%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE---QMEW----ASCEYYSHHGKM 57 + I I GDGIG E+ I V+ +A E L+++ +EW E Y G Sbjct: 24 LTIGYIDGDGIGPEITGAMIGVVNSAIE-----LAYQGSRSIEWHKILIGTEAYEKFGTY 78 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P+D +++ + +Y + +PD L L R+ Y N+R ++ G+ Sbjct: 79 VPEDSIKEIQK---MYIAMKSTLNFMPDKRDLNTIL---RKRLGLYSNIRILKYIEGMDI 132 Query: 118 P-----------LAGKQPGDIDFYVVRENTEGEY----SSLGGRVNEGTEHEVVIQESVF 162 P + P FY E+T+ + G + + ++ Q Sbjct: 133 PVNTFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFR 192 Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQH 222 TR+ + +RY+ + + T+ + +++ A + E A + E+ ++ Sbjct: 193 TRKIAKQAVRYSRR--NGKKKITILESQQNHEFA---NWCIEEASAQEDVGYEVLKTREF 247 Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV 282 + R + PE F+V++ N+ L D GTI I +++ E ++FE V Sbjct: 248 M----KRLISSPEDFEVILVDNVLSQTLVDY---LAGTINIEYGSSIGDE---CAVFEAV 297 Query: 283 HGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 S P G + A+P++ I +G ML +G E Q N I AA + Sbjct: 298 QSSLPSEAGYDAADPLSFILSGCEMLMHIG-WVEAAQIIENAISAAFRD 345 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 58.2 bits (139), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/134 (34%), Positives = 68/134 (50%), Gaps = 27/134 (20%) Query: 97 RREFDQYVNLRPVRLFPGVPCPLAGKQPG---DIDFYVVRENTEGEYSSLGGRVNEGTEH 153 R+E D + +L V C QP ++D V+RENTEGEY+ G EH Sbjct: 70 RKELDLFASL--------VDCFNLNGQPSRHENVDIVVIRENTEGEYA--------GREH 113 Query: 154 EVV--IQES---VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL--AISMPYWDERV 206 EVV + ES T+ DRI +YAFE A RK +T A +NG ++ ++ E Sbjct: 114 EVVPGVIESFQVTMTKFWSDRIAKYAFEYAHFSKRKKVT-AVHNNGKYEKLADAFFLESC 172 Query: 207 EAMAENYPEIRWDK 220 + +A+ YP I +++ Sbjct: 173 QEVAKMYPNITYNE 186 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 57.8 bits (138), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 2/80 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 +KT +IA+IPGD IG EV+ I VL++ E + L F +++W + Y GK MP Sbjct: 6 VKTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDWGTAR-YKRTGKYMPA 64 Query: 61 DWHEQLSRFDAIYFGAVGWP 80 D L F A FGAVG P Sbjct: 65 DGLSTLKTFHAGIFGAVGAP 84 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 57.0 bits (136), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 82/196 (41%), Gaps = 10/196 (5%) Query: 93 LLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE 152 LLK R+E Y ++RP L Q + + + L R G+ Sbjct: 47 LLKLRKEMGTYGSMRPCFFASD---SLVAPQGRGVPRHRLCHCARAHRRYLLWRAQTGSG 103 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN 212 + ++ V+R A L + R K L S +N LA S + E + Sbjct: 104 SAWNTEP--YSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSRFWRKVMTETFEKE 161 Query: 213 YPEIRWDKQHIDILCARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL-- 269 +P+++ + Q I+ V P + VVV S LFGDI+SD +IG+ PSA+L Sbjct: 162 FPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPDSIGLLPSASLSG 221 Query: 270 --NPERTFPSLFEPVH 283 + R ++EP+H Sbjct: 222 IPDGNRKSNDIYEPIH 237 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 56.2 bits (134), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 5/114 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 41 KRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCA-LDLTGVPLPEET 99 Query: 63 HEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + DA+ GA+G W D+ H+ LL+ R + NLRP + P Sbjct: 100 LLVAKQSDAVLLGAIGGYKW-DSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/134 (29%), Positives = 64/134 (47%), Gaps = 12/134 (8%) Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 ++ + P R+ + A NL GDI SD+ A G++ A S + + T LFE HG+A Sbjct: 428 LSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTL--LFEAPHGTA 485 Query: 287 PDIYGKNIA--------NPIATIWAGAMMLDFLGNGDER--FQQAHNGILAAIEEVIAHG 336 D+Y + + N A I+A A L+ L ++ + + AA+ E +A G Sbjct: 486 HDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNAPLAEYAEALKAALIETVAQG 545 Query: 337 PKTPDMKGNATTPQ 350 T D+KG P+ Sbjct: 546 TITGDLKGKTLAPE 559 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 54.7 bits (130), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 84/395 (21%), Positives = 158/395 (40%), Gaps = 79/395 (20%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 ++T+R+ G G G+E++ RV+Q A+++ F + +S Y+S+H + + Sbjct: 3 IQTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVR---SSSTYHSYHTLTVSGE 59 Query: 62 WHEQLSRF------DAIYF-----GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 ++ DAI + A G ++ L R+ Q + Sbjct: 60 DKNLITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYLVRQHLQAAKVEHFS 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRI 170 L G +VR+ +G Y+ G + + + + F++ DRI Sbjct: 120 LGDGNA------------LLMVRDEAQGFYA---GDNTYSADQLSITRTTSFSKPVFDRI 164 Query: 171 LRYAFELA------QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQH-I 223 +R+A + A ++ P+K ++M Y + + + + E +W Q I Sbjct: 165 IRFALDRAAENWGPENVPKK------------VTMAYKFHLFDGVFQAW-EPQWKAQFGI 211 Query: 224 DILCARFVMQPERFD------------VVVASNLFGDI-----LSDLGPACTGTIGIAPS 266 D +QP+ + +++A N + D+ L+ G + T+ A + Sbjct: 212 DFD----FIQPDTLNRSLMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETM-YAEN 266 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFL--GNGDERFQQAHNG 324 L P+ S ++ VHGSA I K + NP ATI A A +L+ G G ++ + Sbjct: 267 VYLRPDVNGLSEYQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGIQKLTE---- 322 Query: 325 ILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 AI+ ++ TPD G+ T + D + I Sbjct: 323 --QAIQSLLQRKLTTPDQGGSLKTEETVDHFLQAI 355 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 53.5 bits (127), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/266 (19%), Positives = 113/266 (42%), Gaps = 30/266 (11%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM-----MPD 60 ++A + GD V+ + +++++ + +FE E + +G + +P+ Sbjct: 3 KLAILKGDKESSSVIDRALGIIKSSVND---STAFEVTELP----FGVNGVLSFNEPLPN 55 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 +L +D I GA+ +S+ SL+ R+ + + + V++ P Sbjct: 56 QTLRELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASP 115 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVI----QESV-FTRRGVDRILRY 173 L + D DF +V+ R N+ + + + Q+++ + +R V++++ Sbjct: 116 LKNQIVRDTDFIIVQS---------AKRANDHVDGNISVDDFAQDTITYEQREVEQVITA 166 Query: 174 AFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 FE A +R R +T T + S W E +A+ YP++ + + + + + Q Sbjct: 167 GFERAMNRKR-AVTVVTPFDSFYTS-KIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQ 224 Query: 234 PERFDVVVASNLFGDILSDLGPACTG 259 P DVVVA +L++ TG Sbjct: 225 PTSLDVVVAPKWVDQVLNEESQKITG 250 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/135 (27%), Positives = 58/135 (42%), Gaps = 28/135 (20%) Query: 239 VVVASNLFGDILSDL----------GPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 +++A N + DI+ + +C+ + + P N E ++ HGSA D Sbjct: 235 LMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSE------YQTTHGSADD 288 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI----AHGPKTPDMKG 344 I GK I NP ATI A A +L+ G GI A +++ + + TPD G Sbjct: 289 ITGKGIVNPSATIRAAAAILERFGGC--------VGIDAKVDDTLNILQKNKSGTPDQGG 340 Query: 345 NATTPQVADAICKII 359 N TT D + + Sbjct: 341 NLTTAAFVDVFLRTL 355 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 48.5 bits (114), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 27/77 (35%), Positives = 38/77 (49%), Gaps = 1/77 (1%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDG+G EV+P + VL A G SFE++ G +P + Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGVA-LDLVGVPLPKET 97 Query: 63 HEQLSRFDAIYFGAVGW 79 + + DA+ GAVGW Sbjct: 98 LIRAKQSDALLLGAVGW 114 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 47.4 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 28/81 (34%), Positives = 44/81 (54%), Gaps = 4/81 (4%) Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK 338 +EP GSAPDI GKNIANPIA I + AM++ + + + I +A+ + + G + Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRY----TMKLPIISDQIESAVIDTLKKGYR 66 Query: 339 TPDMKGNATTPQVADAICKII 359 T D+ + + + I II Sbjct: 67 TLDIANDKEKCESTNDIGDII 87 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/72 (43%), Positives = 39/72 (54%), Gaps = 12/72 (16%) Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVV--IQES--VFTRRGVDRILRYAFELAQSR 181 D+D VV ENTEGEYS+L EHE V + ES + T+ RI YAF+LAQ Sbjct: 27 DVDILVVWENTEGEYSNL--------EHESVKGVTESLKIMTKAKSLRIAEYAFQLAQKM 78 Query: 182 PRKTLTSATKSN 193 K + + K N Sbjct: 79 GCKKVMAVHKVN 90 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 45.8 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 31/114 (27%), Positives = 51/114 (44%), Gaps = 9/114 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I I GDGIG E++ E +VL ++G + +E + C G + D+ Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCS-IDATGVPLTDEAIAA 62 Query: 66 LSRFDAIYFGAVG-------WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLF 112 DA+ G++G W P+ + LLK R+ + + NLRP L+ Sbjct: 63 AKASDAVLMGSIGGNTATSPWYKLAPE-LRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 45.4 bits (106), Expect = 0.003, Method: Compositional matrix adjust. Identities = 29/77 (37%), Positives = 39/77 (50%), Gaps = 6/77 (7%) Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TP 340 VHGSAP G NP A + +G MML +L +A I +++V+A T Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNE-----HEAATRIEKGVDKVLAEAKHLTY 58 Query: 341 DMKGNATTPQVADAICK 357 D G A+T + ADAI K Sbjct: 59 DAGGTASTDEYADAIIK 75 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 45.1 bits (105), Expect = 0.004, Method: Compositional matrix adjust. Identities = 23/50 (46%), Positives = 26/50 (52%), Gaps = 5/50 (10%) Query: 94 LKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSL 143 L R+ Y N+RP PGV P D+D VRENTEGEYS L Sbjct: 112 LTLRKALGLYANVRPCVSIPGVQTPY-----DDVDVVTVRENTEGEYSGL 156 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 44.3 bits (103), Expect = 0.007, Method: Composition-based stats. Identities = 27/80 (33%), Positives = 45/80 (56%), Gaps = 8/80 (10%) Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM- 342 GSAPDI GKNIANPIA I + AM++ + + + + I +++ + + G KT D+ Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRY----TMKLHKIADDIESSVIDALKKGYKTLDIA 57 Query: 343 ---KGNATTPQVADAICKII 359 + + +T + D I I+ Sbjct: 58 NVNETHISTSDMGDVISNIL 77 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 43.9 bits (102), Expect = 0.009, Method: Compositional matrix adjust. Identities = 32/94 (34%), Positives = 45/94 (47%), Gaps = 9/94 (9%) Query: 94 LKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH 153 LK + D YV R FPG C G +D ++ +N G ++ L EG Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFPG-----VDIQLIGQNNMGIFNELEYSPVEG--- 183 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLT 187 VV SV +++G D+ LRYAF+ A RK +T Sbjct: 184 -VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVT 216 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 42.7 bits (99), Expect = 0.018, Method: Compositional matrix adjust. Identities = 50/206 (24%), Positives = 85/206 (41%), Gaps = 13/206 (6%) Query: 155 VVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP 214 VV SV +++G D+ LRYAF+ A RK +T K+ IS E + + +Y Sbjct: 15 VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLVEAAQRLHCHYK 74 Query: 215 EIRWDKQHIDILC-ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPER 273 + + +R + +P FD + AS + LS + C+G G A + Sbjct: 75 DCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAI---CSGVCGGANLFSAVEIG 131 Query: 274 TFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI 333 ++F+P+ + N AN A ++ F G ++ A + ++ + Sbjct: 132 DHHAVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGHDKCADA---LWCELKRTM 185 Query: 334 AHGPKTPDMKGNATTPQVADAICKII 359 G +T + G T V IC II Sbjct: 186 NEGIRTKEFGGQDTGEYV---ICNII 208 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 41.2 bits (95), Expect = 0.057, Method: Compositional matrix adjust. Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 3/79 (3%) Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP 340 P+HG APDI G IANP A + A +L G +E QQ N I +A E TP Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGY-EELAQQVENQIESAFYE--NRDQTTP 265 Query: 341 DMKGNATTPQVADAICKII 359 D G T + + + I Sbjct: 266 DQGGVLNTEKYMAMMVECI 284 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 479 e-133 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 472 e-131 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 445 e-123 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 428 e-118 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 422 e-116 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 418 e-115 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 416 e-115 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 415 e-114 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 402 e-110 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 399 e-110 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 397 e-109 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 396 e-109 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 394 e-108 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 393 e-108 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 392 e-108 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 391 e-107 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 390 e-107 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 387 e-106 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 386 e-106 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 385 e-105 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 385 e-105 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 384 e-105 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 384 e-105 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 382 e-104 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 381 e-104 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 381 e-104 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 379 e-104 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 377 e-103 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 376 e-103 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 376 e-103 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 375 e-102 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 375 e-102 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 374 e-102 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 374 e-102 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 373 e-102 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 372 e-101 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 370 e-101 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 370 e-101 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 370 e-101 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 368 e-100 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 366 e-100 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 365 1e-99 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 365 1e-99 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 365 2e-99 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 364 3e-99 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 363 5e-99 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 361 2e-98 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 359 6e-98 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 359 8e-98 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 359 1e-97 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 358 1e-97 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 356 7e-97 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 355 1e-96 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 354 2e-96 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 354 3e-96 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 353 4e-96 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 353 8e-96 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 351 2e-95 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 349 1e-94 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 349 1e-94 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 348 2e-94 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 348 3e-94 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 347 4e-94 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 347 5e-94 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 346 6e-94 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 346 8e-94 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 344 2e-93 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 344 3e-93 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 343 6e-93 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 343 8e-93 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 341 2e-92 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 341 2e-92 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 341 3e-92 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 339 7e-92 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 339 7e-92 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 339 7e-92 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 339 9e-92 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 338 1e-91 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 338 2e-91 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 338 2e-91 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 337 3e-91 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 337 3e-91 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 337 4e-91 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 336 5e-91 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 336 9e-91 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 336 1e-90 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 335 2e-90 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 333 9e-90 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 330 5e-89 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 329 1e-88 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 328 2e-88 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 327 4e-88 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 326 6e-88 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 326 7e-88 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 326 7e-88 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 326 8e-88 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 325 1e-87 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 325 1e-87 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 325 1e-87 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 325 1e-87 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 324 2e-87 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 324 4e-87 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 324 4e-87 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 323 8e-87 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 322 1e-86 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 319 1e-85 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 318 1e-85 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 317 3e-85 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 317 3e-85 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 316 1e-84 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 314 4e-84 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 310 6e-83 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 309 7e-83 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 309 1e-82 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 308 2e-82 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 307 3e-82 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 306 8e-82 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 306 8e-82 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 306 9e-82 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 304 5e-81 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 303 6e-81 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 302 1e-80 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 302 1e-80 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 300 4e-80 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 300 5e-80 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 298 2e-79 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 297 4e-79 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 295 2e-78 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 292 9e-78 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 292 1e-77 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 292 1e-77 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 291 3e-77 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 290 7e-77 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 289 1e-76 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 289 2e-76 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 287 3e-76 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 286 7e-76 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 286 8e-76 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 281 2e-74 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 279 1e-73 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 278 3e-73 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 276 1e-72 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 269 1e-70 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 269 1e-70 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 268 2e-70 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 268 3e-70 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 266 8e-70 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 266 9e-70 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 263 6e-69 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 262 1e-68 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 262 2e-68 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 260 4e-68 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 259 1e-67 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 257 4e-67 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 252 1e-65 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 241 3e-62 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 237 5e-61 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 235 1e-60 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 234 6e-60 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 231 3e-59 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 229 9e-59 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 224 6e-57 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 219 2e-55 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 197 7e-49 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 187 8e-46 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 177 4e-43 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 170 5e-41 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 167 8e-40 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 164 4e-39 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 160 7e-38 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 160 9e-38 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 155 3e-36 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 145 2e-33 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 140 9e-32 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 137 5e-31 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 128 2e-28 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 123 7e-27 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 116 1e-24 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 96 2e-18 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 92 2e-17 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 90 9e-17 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 83 2e-14 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 78 5e-13 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 78 6e-13 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 60 1e-07 Sequences not found previously or not previously below threshold: UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 156 2e-36 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 128 3e-28 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 111 5e-23 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 102 2e-20 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 96 2e-18 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 95 3e-18 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 93 1e-17 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 93 2e-17 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 90 1e-16 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 88 5e-16 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 86 1e-15 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 85 5e-15 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 84 9e-15 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 84 1e-14 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 83 1e-14 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 83 1e-14 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 82 2e-14 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 81 5e-14 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 79 2e-13 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 77 8e-13 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 73 2e-11 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 72 4e-11 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 63 1e-08 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 63 2e-08 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 63 2e-08 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 59 3e-07 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 59 3e-07 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 58 5e-07 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 57 1e-06 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 56 2e-06 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 56 2e-06 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 55 6e-06 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 54 7e-06 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 52 4e-05 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 51 5e-05 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 49 2e-04 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 48 5e-04 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 48 6e-04 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 43 0.017 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 43 0.018 UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis R... 43 0.024 UniRef50_P41566 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 42 0.032 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 42 0.032 UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot... 42 0.041 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 479 bits (1232), Expect = e-133, Method: Composition-based stats. Identities = 277/359 (77%), Positives = 310/359 (86%), Gaps = 1/359 (0%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + RIAAIPGDGIG EVLPEGIRVL+AAA + G AL F+ EWASC+YY HGKMMPDDW Sbjct: 5 SFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDDWA 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 EQL ++DAIYFGAV WPD VPDHISLWGSLLKFRREFDQYVN+RPVRLFPGVPC LA ++ Sbjct: 65 EQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCALANRK 124 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 GDIDF VVRENTEGEYSSLGG + E TE+E+VIQES+FTRRGVDRIL+YAF+LA+ R R Sbjct: 125 VGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAEKRER 184 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVA 242 K +TSATKSNG+AISMPYWD+R EAMA +YP + WDKQHIDILCARFV+QPERFD VVVA Sbjct: 185 KHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDVVVVA 244 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGPAC GTIGIAPSANLNPER FPSLFEPVHGSAPDI+GKNIANPIA IW Sbjct: 245 SNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPIAMIW 304 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 +GA+ML+FLG GDER+Q+AH+ +L AIE VIA G TPDM G +T QV AI + R Sbjct: 305 SGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDMGGTLSTQQVGAAISDTLAR 363 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 472 bits (1214), Expect = e-131, Method: Composition-based stats. Identities = 255/358 (71%), Positives = 298/358 (83%), Gaps = 1/358 (0%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K RIA IPGDGIG EV+PEG+R L A + R+G ++E +EWASC+YY+ HG+MMPDDW Sbjct: 39 KVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMPDDW 98 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 QLS DA+ FGAVGWP+TVPDHISLWGSL+KFRREFDQYVNLRP RLF GVPCPLAG+ Sbjct: 99 KTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPLAGR 158 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + GDIDF +VRENTEGEYS++GG + EGTE E V+Q++VFTR G +R+L++AFELAQ R Sbjct: 159 KAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQRRA 218 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K LT ATKSNG+AISMP+WD R MA YP++ WDKQHIDILCARFVMQP+RFDVVVA Sbjct: 219 -KRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDVVVA 277 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGPACTGTIGIAPSANLNPER FPSLFEPVHGSAPDI GK+IANPIA IW Sbjct: 278 SNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIAMIW 337 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + AMM+DFLG G ++AH+ I+AAIE V+ HGP+T DM G A+T +V DAI +L Sbjct: 338 SAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHLL 395 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 445 bits (1145), Expect = e-123, Method: Composition-based stats. Identities = 224/360 (62%), Positives = 268/360 (74%), Gaps = 9/360 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +IA IPGDGIG EV+PEGIRVL+AA+ ++GF L+F +W SC Y G MMP D Sbjct: 5 QQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDW-SCARYHSQGSMMPSDG 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L DAI+ GAVG VPDH+SLW L+ RREFDQYVNLRPVRL PGVPCPLA K Sbjct: 64 IERLRDSDAIFLGAVG-FPGVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANK 122 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +PGDIDF++VRENTEGEYS +GGR+ GTEHE V QE++FTRRG DRI+RYAF+LA+ Sbjct: 123 KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFDLAKKLG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +TSATKSNG+ SMP+WDER A+ YP+IR D+ HIDIL ARF M PERFDVVV Sbjct: 183 RNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPERFDVVVG 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGP TGTI +APSAN+NPER +PS+FEPVHGSAPDI G+ IANPI IW Sbjct: 243 SNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIW 302 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH--GPKTPDMKGNATTPQVADAICKIIL 360 +GAMML+ LG +A I+ AIE V+ H TPD+ G A+T Q+ I + +L Sbjct: 303 SGAMMLEHLGQ-----PEAAAAIMQAIETVLTHPDRVHTPDLGGRASTQQMGAEIARAVL 357 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 428 bits (1100), Expect = e-118, Method: Composition-based stats. Identities = 182/360 (50%), Positives = 244/360 (67%), Gaps = 8/360 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ +IAAIP DGIG EV+ G++VL+A +R G F++ E +W S +YY +G MMP Sbjct: 1 MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGS-DYYKKNGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL +FDAI+FGAVG PD VPDHI+LWG L + FDQY N+RP ++ PG+ PL Sbjct: 60 DGLEQLKKFDAIFFGAVGAPD-VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLR 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 PGD+D+ +VREN+EGEYS GGR ++G EV + ++FTR GV RI+RYAF+LAQ+ Sbjct: 119 NCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQA 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN M WDE +++ +P++ WDK +D + R ++P+ D + Sbjct: 179 RPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++G+AP+AN++PER FPS+FEP+HGSA DI GK IANP+AT Sbjct: 239 VATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVAT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W A ML+ LG D A +++A+E V G TPD+ G A T QV DA+C+ I Sbjct: 299 FWTAAQMLEHLGEKD-----AATRLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAIA 353 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 422 bits (1085), Expect = e-116, Method: Composition-based stats. Identities = 173/359 (48%), Positives = 231/359 (64%), Gaps = 9/359 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 T RIA+IPGDGIG EV+ I+V++ A+ G F + F + W YY HG+ + +D Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPW-GTAYYKEHGRYVSEDC 104 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L +FDA FGAVG PD VPDHISLWG LL R Y N+RPVR FPG CPL Sbjct: 105 LDTLRKFDAGLFGAVGAPD-VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPL-NT 162 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ +VREN+EGEYS GGR + G E + ++FTR G++RI+R+AFE+AQSRP Sbjct: 163 ATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEVAQSRP 222 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK LT TKSN + M WD+ +A+++P++ WDK +D + R V +P+ D +V Sbjct: 223 RKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSIDTIVG 282 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NL DILSDL A G+IG+APS+NL+P R PS+FEPVHGSA DI GK +ANP+AT W Sbjct: 283 TNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFW 342 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + A ML +LG ++A ++ +E+V A G TPD+ G + T V DA+ K I R Sbjct: 343 SAAEMLSWLGE-----KEAAKQLMDCVEKVCAAGILTPDLGGTSNTQGVVDAVKKEIER 396 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 418 bits (1076), Expect = e-115, Method: Composition-based stats. Identities = 176/362 (48%), Positives = 241/362 (66%), Gaps = 10/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M+ RIA +PGDGIG EV+ E ++VL+ ++ + F + W S EYY HG+MMP+ Sbjct: 1 MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNS-EYYLQHGRMMPE 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + L +DAI FGA+G P VPD IS+W ++ R+ F QYVNLRPV+ G+P Sbjct: 60 NGLDILKNYDAILFGAIGDPR-VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFI 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 Q I+F +VREN EGEYS+ GGR+ +GT+ E+ +Q ++ TR+G +RI RYAF+ A+ Sbjct: 119 -HQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKK 177 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + +ATKSN + SM WDE +E +A YP+I+ +K +ID L A FV +P+ V+ Sbjct: 178 HGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDLG A G +GI+PSAN+NPE FPS+FEPVHGSAPDI GK ANPIA Sbjct: 238 VASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 IW+ A+ML LG D + IL AIE+V HG T D+ GN+TT ++ + I + I Sbjct: 298 IWSAALMLQSLGRED-----LASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQI 352 Query: 360 LR 361 ++ Sbjct: 353 VK 354 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 416 bits (1069), Expect = e-115, Method: Composition-based stats. Identities = 179/362 (49%), Positives = 230/362 (63%), Gaps = 9/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MKT RIA IPGDGIGKEV+P G + +Q AE G F F+ +W +YY HG MMP Sbjct: 1 MKTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGG-DYYRRHGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E L DAI FG+ G PD + DHI+LWG LK + DQY N+RP RL PG+ PL Sbjct: 60 DGLEPLRDKDAILFGSAGDPD-IADHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLK 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D+ +VREN+EGEYS +GGRV++G E S+ TR GV+RILRYAF LAQS Sbjct: 119 RCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFRLAQS 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN +M WDE ++ +P++RWDK+ +D AR V +P D + Sbjct: 179 RPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPASLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++GIAP+ N++PER PS+FEP+HGSA DI GK +ANPI T Sbjct: 239 VATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 W+ M+L+ LG QA ++ A+E V A T D+ G ATT QV A+C+ + Sbjct: 299 FWSVVMLLEHLGE-----HQAAARMMRAVESVTADQALHTRDLGGTATTEQVTQAVCQHL 353 Query: 360 LR 361 + Sbjct: 354 RQ 355 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 415 bits (1067), Expect = e-114, Method: Composition-based stats. Identities = 187/361 (51%), Positives = 244/361 (67%), Gaps = 11/361 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IAAIPGDG+GKEV+ +VL AAE G + SF W SC+YY HGKMMP+ Sbjct: 3 MKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPW-SCDYYLEHGKMMPE 61 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L++F+A++ GAVG P VPDHISLWG LLK RRE + +N+RP + G+ PL Sbjct: 62 DGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPLL 121 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 P D DF V+REN+EGEYS +GGR++ G + E+ IQ +VFTR+ +R++R+AFELA+ Sbjct: 122 --HPNDFDFVVIRENSEGEYSEVGGRIHRG-DDEIAIQNAVFTRKATERVMRFAFELAKK 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R +TSATKSNG+ +MP+WDE + A +Y I QHID L A FV +PE FDV+ Sbjct: 179 R-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDIL+D+ + G+IGIAPSAN+NP +PS+FEPVHGSAPDI G+ +ANPI Sbjct: 238 VASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 IW +MLD G ++ IL +E+V A G KT D+ G +TT +V D IC + Sbjct: 298 IWTAKLMLDHFGE-----EELGAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEICSRLR 352 Query: 361 R 361 + Sbjct: 353 K 353 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 402 bits (1033), Expect = e-110, Method: Composition-based stats. Identities = 180/358 (50%), Positives = 218/358 (60%), Gaps = 12/358 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ IA IPGDGIG++V +VL A GF L+ W SC +Y G MMP D Sbjct: 1 MKSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPW-SCAFYKETGAMMPPD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L RFDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL GV PL Sbjct: 60 GIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLKA 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV++GT EV ++ S+FTR GV+RILR+ F+ A+ R Sbjct: 120 ---EGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQARQR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ L S TKSN SM WDE +A YP++ HID + AR VM PE DVVV Sbjct: 177 -RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLDVVV 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 W+GAMMLD LG +A ++ A+E A G T G T + A+ + Sbjct: 296 WSGAMMLDHLGQ-----ARAARKVIEALERTTARGIGTVP--GKNRTETITAAVLAAL 346 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 399 bits (1025), Expect = e-110, Method: Composition-based stats. Identities = 127/357 (35%), Positives = 181/357 (50%), Gaps = 27/357 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T +I IPGDGIG EV +RVL+A G +E A E Y + + +P + + Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA----TGLKFEWESFA-AGAEAYEKYKEYIPKELN 56 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G V T P ++ R+ F+ Y N+RP+R PGV Sbjct: 57 ESIERTRIGLKGPV----TTPIGGGFSSINVELRKRFELYANVRPIRNLPGVHTRYP--- 109 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D VVRENTEG YS + V G VV + T + RI ++AF A+ R Sbjct: 110 --GVDLVVVRENTEGLYSGIEHEVVPG----VVESLKIITEKASTRISKFAFNYARKMGR 163 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K + S K+N + +S + +++ YPEI + + +D C + VM P ++D+++ Sbjct: 164 KKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLE 223 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SDL G +G+AP AN+ S+FE VHGSAPDI GKNIANP A I + Sbjct: 224 NLYGDIVSDLCAGLVGGLGLAPGANIGER---ASIFEAVHGSAPDIAGKNIANPTAVIRS 280 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 G +ML L D A N + AA+ V G T DM G +T + AD + + I Sbjct: 281 GILMLRHLDEQD-----AANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 397 bits (1020), Expect = e-109, Method: Composition-based stats. Identities = 167/361 (46%), Positives = 220/361 (60%), Gaps = 11/361 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +IA IPGDG G E + EG++VL AAA + GFAL ++W EYY G+++P Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGG-EYYLRTGEVLPP 71 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL R+DAIY GA+G P+ P I G LL+ R E DQY+NLRPV+L+PGV P+A Sbjct: 72 DAVEQLKRYDAIYLGAIGHPEVRP-GILEKGILLRLRFELDQYINLRPVKLYPGVETPIA 130 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 GK P DIDF VVRENTEG Y+ GG + GT EV IQ S+ TR+GV+R +R+AFE + Sbjct: 131 GKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAFEYCRK 190 Query: 181 R-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R+ +T K+N L + W+ + E YP+I D H+D +C V PE FDV Sbjct: 191 RGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNPEWFDV 250 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDI++DLG G +GIA NLNPE S+FEP+ GSAP GKN+ NP+A Sbjct: 251 IVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPE--GVSMFEPIGGSAPKYTGKNVINPLA 308 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA-TTPQVADAICKI 358 + AGAMML+ LG A I A+++V A K+ T +V D + Sbjct: 309 AVCAGAMMLEQLGETG-----AAARIEEAVKKVCAGHLKSLAAGRMGYGTDEVGDLVVSH 363 Query: 359 I 359 + Sbjct: 364 L 364 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 396 bits (1017), Expect = e-109, Method: Composition-based stats. Identities = 125/354 (35%), Positives = 183/354 (51%), Gaps = 31/354 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIGKEV+ + +L+ + + + A E +GK +PD+ E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILE----KLDLPFEYSYYD-AGDEALEKYGKALPDETLEA 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA+ FGA G +++ RRE + N+RP + G+ C Sbjct: 58 CRKSDAVLFGAAGETAA--------DVIVRLRRELGTFANVRPAKAIEGIECLYP----- 104 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D VVRENTE Y +V V TR +RI RYAFELA+ RK Sbjct: 105 GLDIVVVRENTECLYMGFEFGFG-----DVTEAIRVITREASERIARYAFELAKREGRKK 159 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A++YPEI+++ +ID C VM P RFDV+V +N+ Sbjct: 160 VTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDI+SDL G +G+APSAN+ ++FEPVHG+A DI GK IANP A I Sbjct: 220 FGDIVSDLAAGLVGGLGLAPSANVGER---TAIFEPVHGAAFDIAGKGIANPTAMILTAC 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 MML G +E + A+E+ I G KTPD+ GN T + A+ + ++ Sbjct: 277 MMLRHFGYVEE-----AKKVEEAVEKTIKEGKKTPDLGGNLKTMEFANEVASLL 325 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 394 bits (1013), Expect = e-108, Method: Composition-based stats. Identities = 184/359 (51%), Positives = 231/359 (64%), Gaps = 12/359 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M MR+A IPGDGIG +V E ++V+ +A G + + + ++ SCE Y+ G MMP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA---TGGRIEWTEFDY-SCERYAKTGAMMPP 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L+ FDAI GAVG VPD +SLWG L+ RR F+QYVNLRPVRL PG+ PLA Sbjct: 57 DAPTTLAGFDAILLGAVG-YPGVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLA 115 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + +VRENTEGEYS +GG N G ++E +QESVFTR G +RI+RYAFELA S Sbjct: 116 GVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAFELAAS 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + SATKSNG+ SMPYWD +A YP+ H+D L AR V P DV+ Sbjct: 176 AGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPASLDVI 234 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDL A TG +G+A S N+NPERT S+FE VHGSAPDI G+ IANP+A Sbjct: 235 VASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQ 294 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I AGAM+LD L N I A+++V++ G +TPD+ G ATT Q+ AI + Sbjct: 295 ILAGAMLLDHLNE-----PATANKIRLAVDQVLSDGRVRTPDLGGTATTEQLGTAIAEA 348 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 393 bits (1010), Expect = e-108, Method: Composition-based stats. Identities = 179/318 (56%), Positives = 212/318 (66%), Gaps = 6/318 (1%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT +A IPGDGIG +V + VL AAA + FA W SCEYY HG+MMP+D Sbjct: 1 MKTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPW-SCEYYLEHGRMMPED 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAIY GAVGWP TVPD +SL G LL R+ F+QY N+RP RL GV PL Sbjct: 59 GIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLKA 118 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV+EG +EV ++ SVFTR GV+RILR+ FE A+SR Sbjct: 119 ---EGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQARSR 175 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS TKSN SM +WDE +A YP++ HID + A+ VM P+ DVVV Sbjct: 176 -RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLDVVV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI GKNIANPIA I Sbjct: 235 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAI 294 Query: 302 WAGAMMLDFLGNGDERFQ 319 W+ A MLD LG + Sbjct: 295 WSVAQMLDHLGEAEVSAA 312 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 392 bits (1008), Expect = e-108, Method: Composition-based stats. Identities = 112/359 (31%), Positives = 171/359 (47%), Gaps = 32/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ IPGDGIG E+ RV A +EW + ++ G + + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKA---------PIEWETVVVDANTG--ISKE 69 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E +S+ G + P L R+ F+ Y N+RP PG Sbjct: 70 VIESISKNKIGLKGPIST----PIGTGHQSLNLGLRKTFNLYANIRPCLSIPGHKTRY-- 123 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +++ VVRENTEGEYS + + +G V + T+ RI YAF+ A + Sbjct: 124 ---NNVNTVVVRENTEGEYSGIENQPVKG----VAQSIKIITKEASTRIAHYAFQYALAN 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T K+N + S + + ++ YP I++++ ID C + V+ P + DV+V Sbjct: 177 GRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQMDVMV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDI+SDL G +G+ PS N+ + ++FE VHG+APDI GKN ANP A I Sbjct: 237 LPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGS--AIFEAVHGTAPDIAGKNKANPTALI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML LG+ E + I A+ + G KT D+ GN++ + D + K I Sbjct: 295 LSSIMMLRHLGHFHE-----ASIIENAVLNTLTEGKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 391 bits (1006), Expect = e-107, Method: Composition-based stats. Identities = 177/359 (49%), Positives = 224/359 (62%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT RIA +PGDGIG++V VL+ A GF+L + W SC+YY +G MMP D Sbjct: 1 MKTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPW-SCDYYLENGSMMPAD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL PGV PL Sbjct: 60 GIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPL-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGR+++G ++EV I+ ++FTR+GV+RILR+ FE A++R Sbjct: 118 -RSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQARAR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L S TKSN SM +WDE ++ YP++ HID + AR VM PE DVV Sbjct: 177 -RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLDVVA 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMML+ LG A ++ AIE A G + G T + ++ + Sbjct: 296 WSGAMMLEHLGET-----AAAEKVMDAIETTTARGV--GAIPGKDRTDAITASVLSALG 347 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 390 bits (1001), Expect = e-107, Method: Composition-based stats. Identities = 133/367 (36%), Positives = 194/367 (52%), Gaps = 18/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M++ +A + GDGIG EV+ E ++VL E++GF L+F + + H G +P + Sbjct: 1 MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEF-FVGGAAIDHCGYPLPAE 59 Query: 62 WHEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + DAI FG+VG W + PD G+LL R+ F + NLRP L+ G+ Sbjct: 60 TLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKF 119 Query: 117 CPLAGKQP-GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 CPL D VVRE T G Y V+ + ++RI R AF Sbjct: 120 CPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAF 179 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A R K +TS K+N L S+ W E V MA++YPE+ + +ID + + PE Sbjct: 180 EAAMKRN-KKVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPE 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDV++ SN+FGDI+SD TG++G+ PSA+LN L+EP GSAPDI GK IA Sbjct: 238 SFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNE--AGFGLYEPAGGSAPDIAGKGIA 295 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT---TPQVA 352 NPIA I + AMML + +A + I +A+++V+A G +T D+ ++T T ++ Sbjct: 296 NPIAQILSAAMMLRY----SFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMG 351 Query: 353 DAICKII 359 I + I Sbjct: 352 TLITQAI 358 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 387 bits (995), Expect = e-106, Method: Composition-based stats. Identities = 105/358 (29%), Positives = 169/358 (47%), Gaps = 29/358 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM-MPDDWHE 64 +A IPGDGIG E+ + + A + +E ++ + G+ MP + Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTP--RPTEDGRFRMPQSSLD 2031 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + G + P L R+EF+ Y N+RP + G P Sbjct: 2032 IIRKHGIGLKGPLAT----PIGKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYK---- 2083 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ++D VRENTEGEYS + + +G VV + T R+ R+AF+ A+ R+ Sbjct: 2084 -NVDLVTVRENTEGEYSGIEHVIVDG----VVQSIKLITEEASRRVARFAFQYAKDNGRR 2138 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 ++T+ K+N + +S + A ++ EI + +D +C V P RFDV+V N Sbjct: 2139 SVTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVLVMPN 2198 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSDL G +G+ PS N+ ++FE VHG+APDI G++ ANP A +++ Sbjct: 2199 LYGDILSDLAAGLIGGLGVTPSGNIGETG---AIFESVHGTAPDIAGQDRANPTALLFSA 2255 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 MML ++ + + I +A+ I T D+ G +T Q IC+ I + Sbjct: 2256 IMMLRYM-----NLNKHADLIESAVLATIREAKYLTADLGGRSTCSQYTKEICRQIEQ 2308 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 386 bits (993), Expect = e-106, Method: Composition-based stats. Identities = 156/384 (40%), Positives = 220/384 (57%), Gaps = 32/384 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ I GDGIG EV+ EG +V+ AA E + F + + M + S ++Y G+ + + Sbjct: 1 MVSYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPF-SADHYVKTGETISES 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++LS++ AI+ G++G V + G LL R +DQYVNLRPV+L GV PL G Sbjct: 60 SLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-----------------------HEVVIQ 158 K DIDFYVVRENTE Y +GGR +GT E+ Q Sbjct: 120 KTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQ 179 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 V ++ G RI+ Y+F+LA SRP+K L+S K+N L +W E A YP+++ Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 D ++D + FV PE FDVVV+ N+FGDI++DLG G +G+AP N+NPE T S+ Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPEGT--SM 297 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GP 337 FEP+ GSAP G N NPIATIWAGAM+L+ LG +QA GI+ AIE+ + Sbjct: 298 FEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGE-----KQAAAGIVDAIEQNLKEKKI 352 Query: 338 KTPDMKGNATTPQVADAICKIILR 361 +T D+ G+A T V I +I+ + Sbjct: 353 RTYDLGGSAGTSDVGTDIARIVKQ 376 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 385 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 108/361 (29%), Positives = 181/361 (50%), Gaps = 24/361 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M I+ + GDGIG E+ + +L+A + + +L +++E A + GK +PD Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLE-AGDAVLKNTGKALPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + DA VG S ++ RR D Y N+RP + +P +P Sbjct: 60 ETFEAIKNSDACLKAPVG--------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPS--- 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D+D +VRENTE Y+ + + + + + + RI YAF +A Sbjct: 109 --LRDDVDLVIVRENTEDLYTGEEFDIG-----DAAVAFRIISEKASKRIANYAFTIASK 161 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R K +T KSN + + + +A ++P++++++ ++D + QP+ FDV+ Sbjct: 162 RKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQLFDVI 221 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDILSD G +G+AP+AN+ LFEPVHG+A DI GK IANP + Sbjct: 222 VTTNLFGDILSDESAQVVGGLGMAPAANIGDN---FGLFEPVHGAAFDIAGKQIANPTSF 278 Query: 301 IWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 I + MMLD+LG + D++ + + + +++ + KT D+ G+ TT + I Sbjct: 279 ILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGDKTTMEFTKEIISR 338 Query: 359 I 359 + Sbjct: 339 L 339 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 385 bits (988), Expect = e-105, Method: Composition-based stats. Identities = 159/356 (44%), Positives = 226/356 (63%), Gaps = 15/356 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +I IPGDGIG EV+ E ++ Q+ + + ++W ++Y GK++P D+ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL----NLPIQRDYVDW-GIQHYLKTGKVVPIDYI 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 +Q+ ++DAI G++G P T+PD+++L L++ R++ DQ++ LRP + FPG+P PL Sbjct: 65 DQVKQYDAILLGSLGDPRTLPDYVTLE-PLIQMRQQLDQFLCLRPAKHFPGIPTPLKKC- 122 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +ID VVREN+EGEYS++GG GT E I+ +V TRRG++R++RYAFE ++ R R Sbjct: 123 --EIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEASRKR-R 179 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T ATKSN + M WD EA+A YP++ +K ++D L A V P +FDV+V S Sbjct: 180 NHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGS 239 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLF DI+SDL G++GIAPSAN+NPERTFPSLFEPVHGSA DI GK I +PI T+ A Sbjct: 240 NLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRA 299 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +MML+FLG +E I AI+ I T D+ G TT +V + I I Sbjct: 300 SSMMLEFLGYSEESV-----LIEEAIQSSILQKITTIDIGGTKTTNEVGNFIADYI 350 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 384 bits (987), Expect = e-105, Method: Composition-based stats. Identities = 164/352 (46%), Positives = 224/352 (63%), Gaps = 12/352 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M + +PGDG+G EV+ E + L A +++ + W S +++ HG MMP D + Sbjct: 1 MNVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPWGS-AWWAEHGTMMPADAID 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L DAI GAVG VPD +LWG +LK R+E D +VN+RP RL G+P PLAG+ P Sbjct: 56 VLRGHDAILMGAVG-DPAVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAP 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D+D VREN+EGEY+ +GGRV+ G H+V I+ SVFTRRG +R++RYAF +A +R + Sbjct: 115 HDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASAR-KG 173 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L +ATKSN P+WDE V + +P + D+ +D L AR + P DVVVASN Sbjct: 174 VLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVVASN 233 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDIL+D+ A G +G+A SANL+P P+LFEPVHGSAPDI G+ IANP+ IW+ Sbjct: 234 LFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSA 293 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A+ML+ LG G + ++ A+E V GP+T D+ G ATT +V DA+ Sbjct: 294 ALMLEQLGAG-----EGSRRLMDALETVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 125/359 (34%), Positives = 179/359 (49%), Gaps = 31/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+M+IA IPGDGIG EV+ + +L L F + A G +P++ Sbjct: 1 MKSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHAD-AGDACLKRTGTALPEE 55 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E + A FGA G S +++ RREFD + NLRPV+ PGVPC Sbjct: 56 TLEAVGEARATLFGAAG--------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLYP- 106 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D+DF +VRENTE Y EG + + + TR RI ++AF+ AQ Sbjct: 107 ----DLDFVIVRENTEDLYVGDEEYTPEG-----AVAKRIITRTASRRISQFAFQYAQKE 157 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + +T+ K+N L + + + +A YP++ ++D + QP+ F +V Sbjct: 158 GMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIV 217 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G +G+APSAN+ + +LFEPVHGSAP I GKNIANP A I Sbjct: 218 TTNLFGDILSDEAAGLIGGLGLAPSANIGEKN---ALFEPVHGSAPQIAGKNIANPTAMI 274 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +ML L E I A+++ +A G TPD+ G T ++A I + + Sbjct: 275 LTTTLMLKHLNKKQE-----AQKIEKALQKTLAEGLVTPDLGGKLGTMEMAAEIARHLE 328 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 382 bits (981), Expect = e-104, Method: Composition-based stats. Identities = 146/359 (40%), Positives = 199/359 (55%), Gaps = 24/359 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +I I GDGIG EV+P VL+A G F + + A E + G +P+ Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA----TGLKFEFVEAQ-AGWETFERIGTSVPE 55 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E ++ DA FGA P +G++ RR+ D + N+RP + P+ Sbjct: 56 ATLEAVTHTDATLFGAATSP--TKKVPGFFGAIRYMRRKLDLFANVRPAKH-----HPVP 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G +P +D VVRENTEG Y EG E+ I ++V TR+ RI YA LA S Sbjct: 109 GSRP-GVDLIVVRENTEGLYVEQERSYLEG---EIAIADTVITRKASARIGEYAARLAAS 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK L A K+N L ++ + V A A +PE++ ID + V PERFDV+ Sbjct: 165 RPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPERFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDI+SDL G +GIA S N+ + ++FEPVHGSAPDI GK IANP AT Sbjct: 225 VTTNLFGDIISDLTAGLVGGLGIAASGNIGIKH---AVFEPVHGSAPDIAGKGIANPAAT 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 I +G MMLD LG +A + AA+++V+ GP+TPD+ GNATT Q A+A+ + + Sbjct: 282 ILSGVMMLDHLGE-----HEAARRVEAAVDKVLQEGPRTPDLGGNATTLQFAEAVARSL 335 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 135/356 (37%), Positives = 198/356 (55%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RI I GDGIG EV+P RVL+A G L F + E A E + G +P++ E Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA----TGLPLEFVEAE-AGWETFERRGTSVPEETVE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ A FGA P +G++ RR D Y N+RP + P+ G +P Sbjct: 58 KILSCHATLFGAATSPTRKVPG--FFGAIRYLRRRLDLYANVRPAKS-----RPVPGSRP 110 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D +VRENTEG Y R +V I ++V +++ +RI R A +A+ RPRK Sbjct: 111 -GVDLVIVRENTEGLYVEQERRYL-----DVAIADAVISKKASERIGRAALRIAEGRPRK 164 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 TL A K+N L ++ + + V+ +A+++P + +D + VM+PERFDV+V +N Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GDILSDL G +G+APS N+ ++FEPVHGSAPDI GK IANP A I + Sbjct: 225 LLGDILSDLAAGLVGGLGLAPSGNIGDT---TAVFEPVHGSAPDIAGKGIANPTAAILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMMLD+LG ++A + A++ V+ GP+TPD+ G+ATT +A+ + + Sbjct: 282 AMMLDYLGE-----KEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALK 332 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 127/363 (34%), Positives = 191/363 (52%), Gaps = 28/363 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWH 63 M++ I GDGIGKEV+PE I++L E FE ++ A E +G +P+D Sbjct: 2 MKVCVIEGDGIGKEVIPEAIKILNELGE-------FEIIKGEAGLECLKKYGNALPEDTI 54 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP-----GVPCP 118 E+ D I FGA+ + + ++ R+ F Y N+RP+ F G Sbjct: 55 EKAKEADIILFGAI-TSPKPGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGKIAD 113 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 +ID ++RENTE Y E E++ I E V TR+G +RI+R+AFE A Sbjct: 114 YEFLNAKNIDIVIIRENTEDLYVG-----RERLENDTAIAERVITRKGSERIIRFAFEYA 168 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 RK ++ K+N L I+ + E + ++Y I D +D + PE+FD Sbjct: 169 IKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKFD 227 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V +N+FGDILSD A G +G+APSAN+ ++ +LFEPVHGSAPDI GK IANP+ Sbjct: 228 VIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK---ALFEPVHGSAPDIAGKGIANPM 284 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A+I + AM+ D++G ++ + I A++ + + TPD+ G+ T V D I Sbjct: 285 ASILSIAMLFDYIGE-----KEKGDLIREAVKYCLINKKVTPDLGGDLKTKDVGDEILNY 339 Query: 359 ILR 361 I + Sbjct: 340 IRK 342 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 379 bits (974), Expect = e-104, Method: Composition-based stats. Identities = 125/369 (33%), Positives = 183/369 (49%), Gaps = 20/369 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 199 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ GA+G D+ H+ LL+ R + NLRP + P + Sbjct: 200 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLG-GRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D VVRE T G Y G E+ V+ +DRI R AFE Sbjct: 260 TLKKEVAEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFE 319 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 AQ R R L S K+N L SM W +RV AMA YP++ ++D + V P++ Sbjct: 320 TAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQ 377 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FD +V +N+FGDILSD TG+IG+ PSA++ + P LFEP+HGSAPDI G++ AN Sbjct: 378 FDTIVTNNIFGDILSDEASMITGSIGMLPSASVGE--SGPGLFEPIHGSAPDIAGQDKAN 435 Query: 297 PIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT----TPQV 351 P+AT+ + AM+L + LG G+ A I A+ + + G +T D+ T ++ Sbjct: 436 PLATVLSAAMLLRYGLGEGN-----AAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEM 490 Query: 352 ADAICKIIL 360 + + K + Sbjct: 491 GEQVLKAVE 499 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 109/360 (30%), Positives = 170/360 (47%), Gaps = 34/360 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK----MMPDD 61 + IPGDGIG E+ +++ AA ++W + G M+P + Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA---------PIQWEERNVTAIQGPGGKWMIPSE 83 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E + + G + P L R+ FD Y N+RP G P Sbjct: 84 AKESMDKNKMGLKGPLKT----PIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT- 138 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D++ +RENTEGEYS + + +G VV + T RI +AFE A++ Sbjct: 139 ----DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLITEGASKRIAEFAFEYARNN 190 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R +T+ K+N + +S + ++ +AE+ +I++++ ++D +C V P +FDV+V Sbjct: 191 HRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLV 250 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI GK++ANP A + Sbjct: 251 MPNLYGDILSDLCAGLIGGLGVTPSGNIGAN--GVAIFESVHGTAPDIAGKDMANPTALL 308 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + MML +G D I AA I G T D+ GNA + IC+ + Sbjct: 309 LSAVMMLRHMGLFD-----HAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVK 363 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 127/364 (34%), Positives = 188/364 (51%), Gaps = 18/364 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I IPGDGIGKE+ + VL+ E++G LS+ + A Y G +PDD Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKD-AGGTAYDKFGTPLPDDTI 60 Query: 64 EQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 E D + FGAVG D V + ++L R+ Y NLRPV++ + PL Sbjct: 61 EACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +D +VRE G Y + E ++ VDRI + AFE A+ Sbjct: 121 KPELVKGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETAK 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R +TS K+N LA S W V +AE+YP++ + ++D + ++P +FDV Sbjct: 181 LR-RGKVTSVDKANVLATSR-LWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDV 238 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V NLFGDILSD G+IG+ PSA++ T SL+EP+HGSAPDI GK IANP+ Sbjct: 239 IVTGNLFGDILSDEAAVVGGSIGMMPSASIG---TSTSLYEPIHGSAPDIAGKGIANPMG 295 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KG--NATTPQVADAI 355 TI + AM+L + + + + + A +A G +TPD+ +G A T ++ I Sbjct: 296 TILSAAMLLRYSLHEEAAAKAIEAAVDKA----LADGYRTPDLWKEGFQKANTEEITKVI 351 Query: 356 CKII 359 C+ I Sbjct: 352 CERI 355 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 376 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 126/366 (34%), Positives = 194/366 (53%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA +PGDGIG EV+ E ++VL+ ++ G + G+ +P++ + Sbjct: 1 MKIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGG-DAIDRFGEPLPEETKK 59 Query: 65 QLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 DAI+ G+VG W D P+ G LL R+ + Y N+RP++++ + PL Sbjct: 60 ICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPL 119 Query: 120 AGKQPG-DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 K G +D VRE + G Y G + E ++ R+ V+RI R AFE+A Sbjct: 120 KEKVIGSGVDLVTVRELSYGVYYGQP----RGLDEEKGFDTMIYDRKTVERIARTAFEIA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R RK +TS K+N L SM W + V +A YP++ ++D + +++P +FD Sbjct: 176 KNR-RKKVTSVDKANVLYSSM-LWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ +N+FGDILSD A G++G+ PSA+ + L+EP GSAPDI GKNIANPI Sbjct: 234 VILTTNMFGDILSDESAALPGSLGLLPSASFGDKN----LYEPAGGSAPDIAGKNIANPI 289 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVADA 354 A I + AMML+ + I A+E VI G +T D+ + +T Q+ D Sbjct: 290 AQILSLAMMLEH----SFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDL 345 Query: 355 ICKIIL 360 ICK + Sbjct: 346 ICKKLE 351 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 151/359 (42%), Positives = 208/359 (57%), Gaps = 11/359 (3%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +R+A IPGDGIG EV+ + L+AA E G L +W E Y G MP D Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGG-ERYLRQGAAMPPDA 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + DA+ FGAVG PD VP+H +WG ++ R++ D VNLRPVR FPGVP + Sbjct: 65 ADLVKKTDAVLFGAVGRPD-VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +VRENTEGEY GG + G+ H++ I+ +V +RR ++R AF LA R Sbjct: 124 --DGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFALAGRRS 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L TKSN + P WD V + E YP + + +D + AR + P DV++A Sbjct: 182 -GRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLA 240 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDL G +G+APSAN+ P+ P ++EPVHGSAPDI GK +ANP+A + Sbjct: 241 SNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 +GAM+L+ LG+ D A + A+ + + T D+ GNATT VA A+ + Sbjct: 301 SGAMLLEDLGHTD-----AARRVRDAVADTLRDTRHHTADLGGNATTADVASAVLHTME 354 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 124/367 (33%), Positives = 177/367 (48%), Gaps = 21/367 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA + GDGIG EV+ E +VL A ++ F ++ + + +HG +PD Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGG-AAIDNHGNALPDSTMAG 61 Query: 66 LSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL--- 119 DAI FG+VG W + P +LL R FD + N+RP L P + Sbjct: 62 CIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLR 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + D V+RE T Y E E ++RR V RI AF+ AQ Sbjct: 122 SDISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQ 181 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R +TS K+N LA S W + VE +A YP++ + ++D + V P +FDV Sbjct: 182 KRN-NKVTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 ++ NLFGDILSD+ TG++G+ PSA+LN + ++EP GSAPDI G +ANPIA Sbjct: 240 MLCPNLFGDILSDICAMITGSMGLLPSASLNSD--GFGMYEPAGGSAPDIAGLGVANPIA 297 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVAD 353 I + A+ML + N A I A+ + +G T D+ K +T +V D Sbjct: 298 QILSAALMLRYSLNQG----AAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGD 353 Query: 354 AICKIIL 360 ICK I Sbjct: 354 YICKQIE 360 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 374 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 123/360 (34%), Positives = 184/360 (51%), Gaps = 19/360 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M++A +PGDGIG EV ++VL+A E G L++E + G+ P+ + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGG-AAIDAFGEPFPEPTRK 59 Query: 65 QLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 + +A+ G+VG P D +P I LL R+ D + NLRP ++FPG+ PL Sbjct: 60 GVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D +VRE T G Y G +++ V+R+ R AFE A+ Sbjct: 120 EEIARGVDVLIVRELTGGIYFGEP----RGMSEAEAWNTERYSKPEVERVARVAFEAARK 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R RK + S K+N L + +W + VE + YP++ + Q++D + V P RFDVV Sbjct: 176 R-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVV 233 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V N+FGDILSDL G++G+ PSA+L +FEPVHGSAPDI GK IANP A Sbjct: 234 VTGNIFGDILSDLASVLPGSLGLLPSASLG---RGTPVFEPVHGSAPDIAGKGIANPTAA 290 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 I + AMML+ E ++ + + A+ E PD+ G+A T + + + Sbjct: 291 ILSAAMMLEHAFGLVELARKVEDAVAKALLET-----PPPDLGGSAGTEAFTATVLRHLA 345 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 374 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 175/358 (48%), Gaps = 15/358 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T I A+PGDGIG E+L + +L+ + ++ F E E+ G+ + + Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGAS-IDTFGEPLTEKTL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC--PLAG 121 R DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKA 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++ D +VRE T G Y N + +TR ++RI+ AF+LA SR Sbjct: 121 ERVEGTDLVIVRELTSGIYFGEPRYFNNHE----ALDSLTYTREEIERIVHVAFKLAASR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS K N LA S W + V +++ YPE+ + +D + P++FDV+V Sbjct: 177 -RGKLTSVDKENVLASS-KLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ + + P L+EP+HGSAPDI GKN+ANP I Sbjct: 235 YENLFGDILSDEASVIPGSLGLSPSASFSND--GPRLYEPIHGSAPDIAGKNVANPFGMI 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + AM L A + + I +I HG T D+ G T + + + + + Sbjct: 293 LSLAMCLR----ESLNQPDAADELEQHIYNMIEHGQTTADLGGKLNTTDIFEILSQKL 346 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 175/374 (46%), Gaps = 41/374 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ IPGDGIG EV VL+A G L + ++E A E +G +P E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVE-AGVEVIEKYGTPLPPQVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G +G P + R+E D Y NLRP + PG+ P Sbjct: 58 SIRETRVAIKGPIGT----PVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPFQ---- 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNE----GTEHEV------------VIQESVFTRRGVD 168 DID VVRENTE Y+ + E+ I + G Sbjct: 110 -DIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSR 168 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 RI+++AFE A+ RK +T+ K+N + + + + +A+ YP+I ++ +D +C Sbjct: 169 RIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCL 228 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + +P+ +DV+V +NL+GDI+SDL G +G+AP AN+ ++FE +HGSAP Sbjct: 229 QLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD---GIAVFEAIHGSAPK 285 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM--KGN 345 G+N NP A I +GAMML +LG + + + VIA G T D+ Sbjct: 286 YAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAV-----QSVIAEGKYVTYDLAQGEP 340 Query: 346 ATTPQVADAICKII 359 T ++A+AI + Sbjct: 341 VGTQEMAEAIAARV 354 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 163/358 (45%), Positives = 211/358 (58%), Gaps = 10/358 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+++A IPGDGIG EV+ EG++VL A A R G L + E + + G+++PD Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYEL-GAQRWHATGEVLPDAV 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L + DAI GAVG TVP + G LL+ R F YVNLRPVRL+PGV PLAG Sbjct: 63 EEELRQHDAILLGAVG-DPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGV 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 P DID VVRE TEG Y+ +GG + +GT HE+ Q+SV TR GV+R++RYAF A RP Sbjct: 122 APEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERP 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 LT K N L + W V + YP++ D H+D FV QP RFDVVV Sbjct: 182 CHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVT 241 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI++DLG A G IG+A S N+NPE FPS+FEPVHGSAPDI G+ A+P ATI Sbjct: 242 DNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + ++ML+ LG D Q E G + +T Q+ D I + + Sbjct: 302 SVSLMLEHLGYADAAAQIDQAVAEDLQERAKNGGVR--------STTQIGDDIAQRVA 351 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 110/359 (30%), Positives = 172/359 (47%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + I GDGIG E+ + AA + +E ++ +PDD Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAA----NAPIKWEPVDVTPI--LKDGKTAIPDDAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G + P L RR F+ + N+RP R G P Sbjct: 108 ESVRRNYVALKGPLAT----PVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---- 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V +G VV + T+ +R+LR+AF+ A+S + Sbjct: 160 -DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITKEASERVLRFAFQYARSINK 214 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 K + K+ + +S + +A+++P++ +D + +D C + V P ++ V+V Sbjct: 215 KKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLV 274 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A + Sbjct: 275 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDE---CSIFEAVHGSAPDIAGKGLANPTALL 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +G + I AI + +A G T D+ G A T + A+AI K + Sbjct: 332 LSSIMMLQHMG-----LHEHAGRIQKAIFDTLAEGKALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 132/357 (36%), Positives = 194/357 (54%), Gaps = 31/357 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA-SCEYYSHHGKMMPDDWH 63 MR+A I GDGIG+E++P ++VL A F L FE++ + G + ++ Sbjct: 1 MRLAVIEGDGIGREIIPAAVKVLDA------FGLEFEKVPLELGYTRWERTGTAISNNDL 54 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + DA+ FGA+ VPD + LL R+E D Y N+RPV+ PG+ Sbjct: 55 ETIKGCDAVLFGAITT---VPD-PNYKSVLLTIRKELDLYANVRPVKPLPGITG---VTG 107 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 D DF +VRENTEG YS + E E+ + V TR+G +RI YA +LA+ R + Sbjct: 108 RNDFDFIIVRENTEGLYSGI-----EEIGPELSWTKRVVTRKGSERIAEYACKLAKKR-K 161 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 LT KSN L S + + A + ++ +D + +M+PER+D+VV + Sbjct: 162 NKLTIVHKSNVLK-SDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVTT 219 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLFGDILSD+ A G++G+ PSAN+ + + FEPVHGSAPDI GK IANP+A I Sbjct: 220 NLFGDILSDMCAALVGSLGLVPSANIGEKY---AFFEPVHGSAPDIAGKGIANPLAAILC 276 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 M+L+++G + I AI V+ TPD+ G A+T +V +A+ + +L Sbjct: 277 VKMLLEWMGEPRSQI------IDEAIAYVLQKKIITPDLGGTASTMEVGNAVAEYVL 327 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 118/358 (32%), Positives = 183/358 (51%), Gaps = 23/358 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K R+A I GDG+G +V+ + VL A +++ + + A +G +P + Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVP-AVAGLNTVEKYGTNLPKET 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L D + G P+ SL + + R+ FD Y ++RP + P VP Sbjct: 63 LDTLKETDCVLKGPTTTPEGA---NSLPSANVGIRKYFDLYADVRPNKTLPNVPS----- 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +VRENTEG YS L RVN E I V TR+ +RI++YAF+LA+SR Sbjct: 115 IKPNVDMVIVRENTEGMYSGLDFRVN----QETTIGIRVITRKACERIVKYAFKLAESR- 169 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +K +T K N L +S + + A+ +P+++ D H+D + F+ QPE +DV+V Sbjct: 170 KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFYDVIVT 229 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI+SD G IG SAN+ + ++FEP+HGS P G + NPI TI Sbjct: 230 ENLFGDIISDEAAMVVGGIGTGASANIGDKY---AMFEPIHGSVPKYTGMDKVNPIGTIM 286 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 + MMLD++ +++A I A+ +V+ G T D+ G A +V I + Sbjct: 287 SVKMMLDWM-----DYKEAGKAIEDAVYKVLEEGKILTYDLGGTAKCSEVGKEIASKV 339 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 117/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ R+++A G + +E + + +PDD E + Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + G + P + + R+ F+ + N+RPVR P VP P G + Sbjct: 79 KRTRVVLKGPL----ETPVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG---RN 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+++ R G V I + + +G ++I+R+AFELA++ RK + Sbjct: 132 IDLVVVRENIEDLYAAIEYRETPG----VTIAHKLISYKGSEKIIRFAFELARAEGRKKV 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T ATKSN L ++ ++ E +A YP+I + ID + V PE+F+V+V +NL Sbjct: 188 TCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLN 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDI+SDL G +G A S N E ++FEPVHG+AP GKN+ NP A I M Sbjct: 248 GDIISDLASGLVGGLGFAASGNYGHE---VAIFEPVHGTAPKYAGKNVINPTAMILTAVM 304 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGN---ATTPQVADAICKIILR 361 ML ++ + I A+ + G T D+ G+ +T DAI + R Sbjct: 305 MLRYIDEF-----ETAETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGR 358 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 366 bits (940), Expect = e-100, Method: Composition-based stats. Identities = 103/362 (28%), Positives = 166/362 (45%), Gaps = 35/362 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHH----GKMM 58 + ++ PG GIG E+ + AA ++W E Y+ G ++ Sbjct: 303 QNHKVVLFPGHGIGPEISQAVCDIFAAAK---------VPIDWEHHEIYTKPINEAGDLI 353 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 ++ + + G P + R++ + + N+RP R GV P Sbjct: 354 KEESLNAVINYKWGLKGPFAT----PIGKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTP 409 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + ++D +RENTEGEYS L V G VV + ++ + I RYAFE A Sbjct: 410 YS-----NVDLVTIRENTEGEYSGLEHAVVPG----VVENLKIISQPACENIARYAFEFA 460 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + RK + + K+ + + + ++ YPEI + ++ ID +C + PE FD Sbjct: 461 RKNNRKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEVFD 520 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V NL+GDI+SDL G +G+ S N++ +++E VHG+APDI G N ANP Sbjct: 521 VMVMPNLYGDIVSDLCAGLIGGLGLTASGNIS---HTCAVYEAVHGTAPDIAGLNKANPT 577 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICK 357 A + +G MML +G Q+ I A+ + ++ G T D+ G ATT A+ Sbjct: 578 ALLLSGVMMLKAMG-----LQKEGFAIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAVIG 632 Query: 358 II 359 I Sbjct: 633 HI 634 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 173/366 (47%), Gaps = 30/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + GDGIG E++ + VL+ AA L E +E Y ++ + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D Q+ R A+ G V T P + R+ Y N+RP + P Sbjct: 57 DTWSQIFRTKALLKGPV----TTPQGGGYKSLNVTLRKTLGLYANVRPSCSY----FPFV 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +ID ++REN E Y+ + T V + +R G ++I+R+AFE A Sbjct: 109 NTSAPEIDVVIIRENEEDLYAGIEYHHTADTYESV----KLISRSGSEKIIRFAFEYALK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RKT++ +K N + + + + +A Y I+ D IDI AR + P++FDV+ Sbjct: 165 NNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDILSD+ +G+IG+A SAN+ + ++FE VHGSAPDI G+NIANP Sbjct: 225 VTSNLYGDILSDIAAKISGSIGLAGSANIGKDY---AMFEAVHGSAPDIAGQNIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADA 354 + A MML LG + I A+++ I G T D+ + T + A A Sbjct: 282 LNAAIMMLVHLG-----LTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQA 336 Query: 355 ICKIIL 360 I + Sbjct: 337 IINNLE 342 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 365 bits (937), Expect = 1e-99, Method: Composition-based stats. Identities = 122/363 (33%), Positives = 185/363 (50%), Gaps = 13/363 (3%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T+ IA +PGDGIG+EV+P + ++ AA G Q A +YY+ G +P Sbjct: 7 TLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPASTL 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + + DAI FGA+GWPD + L R E + +RP+R FPG+P L + Sbjct: 67 DACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPR 126 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 IDF +VRE TEG + + G E E TR G R+ +AF++A+ R R Sbjct: 127 AEQIDFVLVREQTEGLFYARGR--GEIRNDEEAYDTMQITRSGTQRVTEFAFDIARQRKR 184 Query: 184 K----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + +T K+N SM ++ + + +A+ + ++ D ++D L V +P FDV Sbjct: 185 RGKPGNVTCVDKANVFQ-SMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKPWTFDV 243 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+APSA++ + LF+P HG+APDI GK ANP A Sbjct: 244 LVTENMFGDILSDLAAGLIGGMGMAPSADIGDKH---GLFQPAHGTAPDIAGKGCANPSA 300 Query: 300 TIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAIC 356 + AMMLD+L G A + A+E ++ P + GNA ++ ++ Sbjct: 301 MFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPMEYGGNANCAEMTRSVI 360 Query: 357 KII 359 + Sbjct: 361 SSL 363 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 365 bits (937), Expect = 2e-99, Method: Composition-based stats. Identities = 136/372 (36%), Positives = 189/372 (50%), Gaps = 29/372 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 I IPGDGIG+EV+P + VL+A G FE + A E + G+ +P Sbjct: 4 APYTILVIPGDGIGREVIPAAVAVLRA----TGLPFHFENAD-AGWECFQRQGEALPSAT 58 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI FGAV P +++ RRE D Y N+RPV F +P + Sbjct: 59 LTAARAADAILFGAVASPGYPVAG--YRSPIVRLRRELDLYANIRPV--FDDLPENGSNP 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR- 181 + +D VVRENTE Y+ ++G I E V TRR RI+R A +LA++R Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGA---TAIAERVITRRASARIMRVACDLARARR 171 Query: 182 --------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 P +T K+N L + + +A+ YP+++ D+ +D + + Sbjct: 172 SARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATR 231 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 PERFDV+V +NLFGDILSD+ A G +G+APSANL +LFEPVHG+APDI GK Sbjct: 232 PERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH---ALFEPVHGAAPDIAGKG 288 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAH-----NGILAAIEEVIAHGPKTPDMKGNATT 348 IANP+A I A++LD L + I AI V A GP TPD+ G+A T Sbjct: 289 IANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVT 348 Query: 349 PQVADAICKIIL 360 + +A+ +L Sbjct: 349 TDITNAVLSHML 360 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 364 bits (934), Expect = 3e-99, Method: Composition-based stats. Identities = 120/366 (32%), Positives = 194/366 (53%), Gaps = 22/366 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK I I GDGIG EV+ + I+ L + R+ S++ + A + G MP + Sbjct: 1 MKK-NIVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNV-LAGAKAIETFGDPMPKE 58 Query: 62 WHEQLSRFDAIYFGAVGW--PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-PCP 118 + + DA+ FG++G D+ P + LLK R+E D Y N+RP+ +PG+ P Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSP 118 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + ++ ++F + RE T G Y GR G E V++ + ++RI +F+ A Sbjct: 119 IKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSFKAA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +SR RK +T K+N L S W E ++ MA +Y ++ + +ID + ++ P +FD Sbjct: 176 RSRNRK-MTLVDKANVLETSR-LWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ N+FGDILSD T ++G+ PSA++ ++ SLFEP+HGS P GKNIANP+ Sbjct: 234 VILTDNMFGDILSDEASILTSSLGLLPSASIGSKK---SLFEPIHGSYPQAKGKNIANPL 290 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 I + +MML++ Q N + A++ I TPD+ + +++T +V D Sbjct: 291 GCILSVSMMLEYF-----EMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDY 345 Query: 355 ICKIIL 360 I K I Sbjct: 346 IEKYIK 351 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 119/355 (33%), Positives = 162/355 (45%), Gaps = 13/355 (3%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI + GDG+G EV+ VL +G + E+ G+ +P Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQD-EYFGGVAIDLTGQPLPQRTLAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 DA+ GAVG P LL R+ + N+RPV + K Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +IDF VVRE T G Y S E EV + R ++RI+ YAF+LA R +K Sbjct: 123 EIDFVVVRELTGGIYFSYPKERTE----EVATDTLTYHRHEIERIVSYAFQLANKR-KKK 177 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +TS K+N L S W E +A YP + + +D + P RFDV+V NL Sbjct: 178 VTSIDKANVLESS-KLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTENL 236 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSD G++G+ PSA+ PSL+EP+HGSAPDI GKN ANPIA + + A Sbjct: 237 FGDILSDEASVLAGSLGMLPSAS--HAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML + I A+ V+ G T D+ G TT A+ + + Sbjct: 295 MML----GQSFGLTREGYAIEEAVSAVLKSGKCTADIGGTETTTSFTKAVIQEME 345 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 121/368 (32%), Positives = 182/368 (49%), Gaps = 20/368 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDGIG EV+ VLQ A G F++M G +P++ Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGG-AALDLVGVPLPEET 103 Query: 63 HEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 DAI GA+G D H+ +L RR+ + NLRP + P + Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDAST 163 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVN-EGTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + EV + ++ +DRI R AFE Sbjct: 164 LKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFET 223 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R R L S K+N L S+ W +RV A+A YP++ ++D + + P++F Sbjct: 224 ARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +N+FGDILSD TG+IG+ PSA+L + P LFEP+HGSAPDI G++ ANP Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGE--SGPGLFEPIHGSAPDIAGQDKANP 339 Query: 298 IATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT----TPQVA 352 +ATI + AM+L + LG ++A I A+ + + G +T D+ ++ Sbjct: 340 LATILSAAMLLKYGLGE-----EKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMG 394 Query: 353 DAICKIIL 360 + + K + Sbjct: 395 EEVLKSVE 402 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 359 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 116/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG E + ++VL+AA L++E E + + +P + E + Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + G + P + + R+ F+ Y N+RPVR FP VP P AG Sbjct: 78 RKTRVVLKGPL----ETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG---RG 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+ + V + + +G ++I+R+AFELA++ RK + Sbjct: 131 IDLVVVRENVEDLYAGIEHMQTP----SVAQTLKLISWKGSEKIVRFAFELARAEGRKKV 186 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 ATKSN + ++ E +A+ YP+I +D + V +PE+F+V+V +N+ Sbjct: 187 HCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMN 246 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSDL G +G APSAN+ E ++FE VHGSAP GKN+ NP A + + M Sbjct: 247 GDILSDLTSGLIGGLGFAPSANIGNE---VAIFEAVHGSAPKYAGKNVINPTAVLLSAVM 303 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKG---NATTPQVADAICKIILR 361 ML +L + I A+ + G T D+ G A T + +AI + + + Sbjct: 304 MLRYLEEFAT-----ADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 107/350 (30%), Positives = 171/350 (48%), Gaps = 15/350 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I A+PGDGIG E+L + +L+ +E++ F E + ++G + ++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVS-IDYYGTPLTNETL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAG 121 + DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 QSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQ 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +VRE T G Y V + + ++ + ++RI+R AF LA R Sbjct: 121 DIVEGTDLVIVRELTSGIYFGEPSYVKKTE----ALDSLKYSSQEIERIVRIAFNLANRR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK LTS K N L S W + V + ++YPE+ + +D + QP +FDV+V Sbjct: 177 -RKKLTSVDKENVL-SSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ +T L+EP+HGSAPDI ++ ANP + Sbjct: 235 TENLFGDILSDEASVIPGSLGLSPSASFG--QTGTRLYEPIHGSAPDIANEDKANPFGMV 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 + A+ L N ++ A N + + + I T D+ G T ++ Sbjct: 293 LSLALCLRESLNQND----AANELESIVYSFIQSNKTTADLGGQYRTSEI 338 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 359 bits (921), Expect = 1e-97, Method: Composition-based stats. Identities = 129/359 (35%), Positives = 184/359 (51%), Gaps = 33/359 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQM-EWASCEYYSHHGKMMPDD 61 +IA IPGDGIGKEV+ I VL + F+ + A E HG +P + Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDE------LDVDFDYIYGIAGDECNEEHGTPLPQE 62 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + DA FGA G ++K R+E + NLRPV+ +P Sbjct: 63 TIDIVRDSDACLFGAAGETAA--------DVIVKIRQEMKMFANLRPVKSYPNTKSLF-- 112 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++DF +VRENTEG Y + E I + V TR +RI+ YAF+ A+ Sbjct: 113 ---ENVDFMIVRENTEGLYIADQEEETEDG----AIAKRVITREAEERIIDYAFQYAKDN 165 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R +T+ K+N L + + + + E YP+I + ++D V QP+ F VVV Sbjct: 166 NRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQVVV 225 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G G +G+ PSAN+ + +LFEPVHGSAPDI G+ ANPIA + Sbjct: 226 TTNLFGDILSDEGAGLVGGLGLIPSANIGADG---ALFEPVHGSAPDIAGQQKANPIAMM 282 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + MML +LG D A + AAI +V++ G T D+ G+ATT +VA A+ + Sbjct: 283 LSAIMMLRYLGEND-----AADKFDAAILKVLSEGKTLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 114/366 (31%), Positives = 171/366 (46%), Gaps = 15/366 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ + GDGIG E+ + VLQAA + + ++ E H + Sbjct: 1 MSNLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEI-GFASLKKHKTTFRSE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + D + G D P R+ FD Y N+RP + G Sbjct: 60 VLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 P ID V+RENTEG YS G +V I TR+G RI F+ A Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAEIGFKYA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R RK L + K+N L S + E +++ YPE+ + +Q +D + A + P FD Sbjct: 176 MER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRDPSVFD 234 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++A+NLFGD LSD G +G+A S N + + HGSAPDI GKNIANP+ Sbjct: 235 VILATNLFGDNLSDAASEIAGGLGLAESINAGENYC---IAQAQHGSAPDIAGKNIANPV 291 Query: 299 ATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAI 355 + I + AMMLD+LG N +++ ++ I AI++ I + +T D+ GN +T D + Sbjct: 292 SLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDIGGNLSTTDFTDVL 351 Query: 356 CKIILR 361 + + Sbjct: 352 ISNLKK 357 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 356 bits (914), Expect = 7e-97, Method: Composition-based stats. Identities = 148/362 (40%), Positives = 205/362 (56%), Gaps = 14/362 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M +T+ +A +PGDGIG EV+ E +RVL+ A +L Q + + ++ G+++ D Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVPA-DVSLDTTQYPFGAG-HFLETGQILTD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 L++ DAI GAVG + I G LLK R FD Y+NLRP L PGV Sbjct: 59 SDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVAS 118 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PLA PG +DF VVRE TEG Y+ GG + GTEHE+ + SV T GV+R +R+AFEL Sbjct: 119 PLAA--PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAFEL 176 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R RK +T K+N L + W V+ +A +P++ D H+D V P RF Sbjct: 177 AEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPSRF 236 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V+ NLFGDI++DL A +G IG+A S N+NP FPS+FEPVHGSAPDI G+ A+P Sbjct: 237 DVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADP 296 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 A I + A++LD LG + + + T D +T +V DAI + Sbjct: 297 TAAILSVALLLDHLGLSEAAARVSAAVSDDLAARA------TGD-AAPRSTAEVGDAILR 349 Query: 358 II 359 + Sbjct: 350 AL 351 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 119/364 (32%), Positives = 193/364 (53%), Gaps = 12/364 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M ++ + + GDGIG EV + +R+L+ G ++ E Y G+ +P Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGE-YQRSGEALP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ DA+ GA+G P+ + L R Y +RP+RL+ PL Sbjct: 60 QSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPL 119 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G PG+IDF +VRE+TEG + E + TR +R+ R AFE A+ Sbjct: 120 KGHGPGEIDFVLVRESTEGLFYGRD--AIADLEADEATNLLRITRSASERVCRLAFETAR 177 Query: 180 SR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +KT+T K+N L SM Y+ + +A+ + +I+ + ++D V +P+ FD Sbjct: 178 RRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFD 236 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APS ++ + ++F+P HGSAPDI G++IANPI Sbjct: 237 VMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDD---AAVFQPSHGSAPDIAGQSIANPI 293 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICK 357 A + AMML++L + + R +A + + AAI +V++ +T DM GN +T ++ D I + Sbjct: 294 AMHLSTAMMLEWLDHPETR--RAADALNAAIADVLSDPTQRTADMGGNLSTVEITDKIAE 351 Query: 358 IILR 361 + + Sbjct: 352 RLSK 355 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 117/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M IA +PGDGIG E + ++L +++ + + + + + G P Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGG-DAINSEGTPFPK 59 Query: 61 DWHEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 + + +AI FGAVG W G+LL R+ F+ + NLRP+ L + Sbjct: 60 STLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKE 119 Query: 117 -CPLA-GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL P ID VRE T G Y + +E +V+ R ++RI A Sbjct: 120 LSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LAQ R RK ++S K+N L SM W E V +A+NYP++ + +ID + + P Sbjct: 180 FKLAQKR-RKRVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNASMQLINNP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 +FD+++ NLFGDILSD +G+IG+ PSA++N L+EP GSAPDI KNI Sbjct: 238 SKFDIILCPNLFGDILSDECAMISGSIGMLPSASINE--HNFGLYEPAGGSAPDIAEKNI 295 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----TTPQ 350 ANPIA I + A++ + + I A+ + + G +T D+ +T + Sbjct: 296 ANPIAHILSIALLFRY----SLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNE 351 Query: 351 VADAICKIIL 360 + D I +I Sbjct: 352 MGDIIAALIK 361 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 354 bits (908), Expect = 3e-96, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 178/366 (48%), Gaps = 16/366 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGF-ALSFEQMEWASCEYYSHHGKMMPD 60 K +A + GDGIG E++P +++L AA G +++ ++ +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPL-GRSAIDEYGEHTPT 79 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + L D G + S R+ F + N+RP + F G Sbjct: 80 KTLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG-----G 134 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFEL 177 D +VRENTEG Y+ G +V I + TR +RI AF+L Sbjct: 135 NAIVEGTDLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAHEAFQL 194 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A++R K +T K+N L ++ + + + + YP++ + HID V + ++F Sbjct: 195 ARTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVRRADKF 253 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V N+FGDILSDL G++GIAPS N + ++ + HGSAPDI G++IANP Sbjct: 254 DVIVTENMFGDILSDLAGEVAGSLGIAPSINSSATH---AMAQASHGSAPDIAGRDIANP 310 Query: 298 IATIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 IA I + AM+L +L DE+ +A + + AA++ +A G TPDM G ++ ADA+ Sbjct: 311 IAMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDMGGTSSCSGFADAV 370 Query: 356 CKIILR 361 R Sbjct: 371 VAATAR 376 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 353 bits (907), Expect = 4e-96, Method: Composition-based stats. Identities = 103/365 (28%), Positives = 169/365 (46%), Gaps = 30/365 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + + + GDGIG E+ + +L AA G L E +E Y + +P + Sbjct: 19 LTPIPVTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQE 74 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + ++R + G + T P + R+ Y N+RP R + P+ Sbjct: 75 AWDSIARTRVMLKGPI----TTPQGGGYKSLNVTMRKTLGLYANVRPCRTYK----PIVT 126 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D+D +VREN E Y+ + R +V + TR G +RI RYAFE A+ Sbjct: 127 TRHPDMDVVIVRENEEDLYAGIEHRQT----QDVAQCLKLITRSGSERIARYAFEYARQH 182 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R +T K N + ++ + + +A YPEI+ Q +D A FV +PE +DVV+ Sbjct: 183 GRSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVL 242 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ TG++G+ S N+ + ++FE +HGSAPD+ +++ANP + Sbjct: 243 LPNLYGDILSDIAAQMTGSVGLGGSVNIG---SGGAIFEAIHGSAPDLA-RDVANPSGLL 298 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG-----NATTPQVADAIC 356 A ML L + ++ A + G T D+ G A T + +A+ Sbjct: 299 LAAVEMLRHL-----KLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVI 353 Query: 357 KIILR 361 + + R Sbjct: 354 ERLGR 358 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 353 bits (905), Expect = 8e-96, Method: Composition-based stats. Identities = 131/368 (35%), Positives = 196/368 (53%), Gaps = 29/368 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K++ I IPGDGIGKEV+P G +VL+ + G + +F + +A + + GK +PD+ Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDL-YAGFQTFQETGKALPDET 80 Query: 63 HEQLSR-FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L FGAV P T + S ++ RRE + N+RPV+ G Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKVEGYS--SPIVALRREMGLFANVRPVKSVEG------- 131 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGR-VNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ ID +VRENTE Y + +++ T V + RI A ++A Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191 Query: 181 R----PRKTLTSATKSNGLAISMPYWDERVEAM----AENYPEIRWDKQHIDILCARFVM 232 R + TLT KSN L+ S + E + + + Y +I++++Q +D + R Sbjct: 192 RLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFR 251 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 +P+ FDV+VA NL+GDILSD A G++G+ PSAN+ PE + EP HGSAPDI GK Sbjct: 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGK 308 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQV 351 IANPIATI + A+ML+FLG+ +A I A++ + G KTPD+ G A+T QV Sbjct: 309 GIANPIATIRSTALMLEFLGH-----NEAAQDIYKAVDANLREGSIKTPDLGGKASTQQV 363 Query: 352 ADAICKII 359 D + + Sbjct: 364 VDDVLSRL 371 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 351 bits (901), Expect = 2e-95, Method: Composition-based stats. Identities = 126/368 (34%), Positives = 191/368 (51%), Gaps = 32/368 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA------AERWGFALSFEQMEWASCEYYSHHGKMMPD 60 I IP DGIGKEV+P ++V+ AA A++ F+L + +E A E + GK +P Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLE-AGWETFQKTGKSLPV 92 Query: 61 DWHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + E L + D FG+V P + S ++ R+ D Y N+RP + Sbjct: 93 ETVEALKNKCDGAIFGSVQSPSHKVEGYS--SPIVAMRKLVDLYANIRPCQDL------- 143 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 ID +VRENTE Y V+ T + + + + T R RI A++LA Sbjct: 144 ----AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEIAYKLA 199 Query: 179 QSRPRK---TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 R + +T KSN L++S + E +++ YP+++ ++Q +D + + ++ P Sbjct: 200 VQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKMILDPT 259 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 ++DVVVA NL+GDILSD G A G +G+ SANL+ +L EPVHGSAPDI+GK I+ Sbjct: 260 QYDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS---FALVEPVHGSAPDIFGKKIS 316 Query: 296 NPIATIWAGAMMLDFLGNGDER---FQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQV 351 NPIATI A AM+L L D + + + + A+ V+ TPD+ G T + Sbjct: 317 NPIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGNTETL 376 Query: 352 ADAICKII 359 DAI K + Sbjct: 377 VDAIIKNL 384 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 108/367 (29%), Positives = 171/367 (46%), Gaps = 30/367 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + I GDGIG E++ + +L+ A R + E +E Y H+ + + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E + R I + T P + R+ + N+RP F P Sbjct: 57 QSWESIERTGVILKAPI----TTPQGGGYKSLNVTIRKTLQLFANIRPSVSF----YPFT 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +++ ++REN E Y+ + R H + + +R G ++I+RYAFE A Sbjct: 109 KTLHPNLNLTIIRENEEDLYAGIEYRQT----HNMYESVKLISRTGCEKIIRYAFEYAVK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T +K N + S + + +A+ YP+I + IDI AR +PE FDV+ Sbjct: 165 NNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDI+SD+ +G++G+A SAN+ ++FE VHGSAPDI G++IANP Sbjct: 225 VTSNLYGDIISDVAAEISGSVGLAGSANIGEHY---AMFEAVHGSAPDIAGQDIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADA 354 + A MML +G GD I A ++ I G T D+ T + A+ Sbjct: 282 LNAAIMMLVHIGQGD-----IATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAEE 336 Query: 355 ICKIILR 361 + K + + Sbjct: 337 VVKRLGQ 343 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 166/360 (46%), Gaps = 30/360 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + IPGDGIG V +V++A + FE+ E +P++ Sbjct: 37 APRTVTLIPGDGIGPLVTGAVEQVMEAM----HAPVHFERYEVLGNMRK------VPEEV 86 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E + R G + P + ++ R+E D + +L PG+ Sbjct: 87 IESVKRNKVCLKGGLAT----PVGGGVSSLNMQLRKELDIFASLVNCINVPGLVT----- 137 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + ++D V+RENTEGEYS L V G VV V T+ +RI RYAFE A Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITKFCSERIARYAFEYAYLNN 193 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T+ K+N + ++ + E +A++Y I +++ +D C + V +PE+FDV+V Sbjct: 194 RKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVT 253 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD-IYGKNIANPIATI 301 NL+G+++++ G G+ P N+ E D + + ANP+A + Sbjct: 254 PNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALL 313 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + AMML L RF + + A+++VI G +T D+ G+ TT +V DA+ + Sbjct: 314 LSSAMMLRHL-----RFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 108/366 (29%), Positives = 167/366 (45%), Gaps = 30/366 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK + I GDGIG E++ ++V+ A G L E++E Y + + Sbjct: 1 MKKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVYSMGNPSGIEPS 56 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L R + T P + R+ Y N+RP + P Sbjct: 57 SWESLKRTKVFLKAPI----TTPQGGGFKSLNVTVRKALGLYANIRPCISY----APFIH 108 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + ID ++REN E Y + R + + TR+G +RI+RYAFE A+ Sbjct: 109 TKHPGIDLVIIRENEEDLYGGIEHRQGVDSFQ----ALKIMTRQGTERIIRYAFEYARCY 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK ++S TK N L I+ + + E +A+ YP+I + IDI A+ P+ FDV+V Sbjct: 165 GRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQSFDVLV 224 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NL+GDILSD+ G++G+ SAN+ E S+FE +HGSAP G+N+ANP + Sbjct: 225 LANLYGDILSDVAVQIAGSVGLGASANIGHEY---SMFEAIHGSAPRRAGQNVANPSGLL 281 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KG----NATTPQVADAI 355 A ML +G + + A + I G T D+ +G T + A + Sbjct: 282 LAAVQMLIHIGQ-----NAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREFARHV 336 Query: 356 CKIILR 361 K + + Sbjct: 337 IKNLGK 342 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 348 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 100/358 (27%), Positives = 153/358 (42%), Gaps = 28/358 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDI-----RNAI 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 67 MAIRRNRVALKGNIETNHNLP--PSHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 119 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 120 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 175 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 176 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 235 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+G+I++++ G G+ AN + + I KNIANP AT+ A Sbjct: 236 NLYGNIVNNVCAGLVGGPGLVAGANYG--HVYAVFETATRNTGKSIANKNIANPTATLLA 293 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIIL 360 MMLD L + I A+ + + TPD+ G TT + I + I Sbjct: 294 SCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIR 346 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 347 bits (891), Expect = 4e-94, Method: Composition-based stats. Identities = 107/364 (29%), Positives = 171/364 (46%), Gaps = 38/364 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY---YSHHGKMMPD 60 ++ I GDGIG E+ ++ AA +EW SC+ + + +PD Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAAN---------VPIEWESCDVSPIFVNGLTTIPD 86 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + +++ G + P L R+ F + N+RP + G Sbjct: 87 PAVQSITKNLVALKGPLAT----PIGKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY- 141 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++D ++RENTEGEYS + V G VV + TR +R++RYAFE A++ Sbjct: 142 ----ENVDLVLIRENTEGEYSGIEHIVCPG----VVQSIKLITRDASERVIRYAFEYARA 193 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-- 238 R + KS ++ + + +++ YP++ + + ID + V P + Sbjct: 194 IGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDA 253 Query: 239 VVVASNLFGDILSDLGPAC-TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 V V NL+GDILSDL G++G+ PSAN+ + S+FE VHGSAPDI G++ ANP Sbjct: 254 VSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHK---ISIFEAVHGSAPDIAGQDKANP 310 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP--KTPDMKGNATTPQVADAI 355 A + + MML+ +G + I A+ IA GP +T D+ G ATT +A+ Sbjct: 311 TALLLSSVMMLNHMG-----LTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAV 365 Query: 356 CKII 359 K + Sbjct: 366 IKRL 369 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 347 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 115/370 (31%), Positives = 170/370 (45%), Gaps = 18/370 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMP 59 M +I +PGD +G+E+ E I+VL+A ++ R FE G +P Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGG-AAIDATGVPLP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 D+ E + DA+ GAVG P + LLK R+E Y NLRP Sbjct: 60 DEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDL 119 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P+ + DF VVRE G Y + E V +T V RI R A Sbjct: 120 SPIKPQFAKGTDFVVVRELVGGIYFG---KRKEDDGDGVAWDSEQYTVPEVQRITRMAAF 176 Query: 177 LAQSR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +A P + S K+N LA S + E + +P ++ Q ID V P Sbjct: 177 MALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPT 236 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 + +++ SN+FGDI+SD G++G+ PSA+L + T L+EP HGSAPD+ Sbjct: 237 HLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-P 295 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 KN NPIATI + AMML + I A+++V+ G +T D+ G+ +T +V Sbjct: 296 KNKVNPIATILSAAMMLK----LSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEV 351 Query: 352 ADAICKIILR 361 DA+ + + + Sbjct: 352 GDAVAEEVKK 361 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 346 bits (889), Expect = 6e-94, Method: Composition-based stats. Identities = 99/358 (27%), Positives = 153/358 (42%), Gaps = 28/358 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 104 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 105 MAIRRNRVALKGNIETNHNLP--PSHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 157 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 213 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 214 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 273 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+G+I++++ G G+ AN + + I KNIANP AT+ A Sbjct: 274 NLYGNIVNNVCAGLVGGPGLVAGANYG--HVYAVFETATRNTGKSIANKNIANPTATLLA 331 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIIL 360 MMLD L + I A+ + + TPD+ G TT + + + I Sbjct: 332 SCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIR 384 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 139/367 (37%), Positives = 190/367 (51%), Gaps = 19/367 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA +PGDGIG EV +RVL A F + F + A E + G P+ Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALGTS-FPIEFRDYD-AGAECFRRTGTAFPEATQV 70 Query: 65 QLSRFDAIYFGAVGWPDTV-PDHISLWGS-LLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A+ GA G PD + PD +K R D Y N+RP+RL G P L GK Sbjct: 71 ACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ--- 179 P DI F +VRENTEG Y++ GG ++ V TR GV+RI+RYA ELA+ Sbjct: 131 GPDDIRFTIVRENTEGLYAARGG--GNIIRGQIATDTLVMTREGVERIVRYAAELARDGQ 188 Query: 180 ---SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 + + +T K+N L S ++ E + + + P I + +D + + +PE Sbjct: 189 GAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERPEH 247 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V NLFGDILSDLG A G +G+APS + + + F+ HGSAP I GK +AN Sbjct: 248 FDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRDHGY---FQGSHGSAPTIAGKGLAN 304 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 PIA I +GAMMLD+LG + D +A I A V+ G TPD+ G+ +T A Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCAA 364 Query: 354 AICKIIL 360 IC + Sbjct: 365 EICATLG 371 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 117/365 (32%), Positives = 182/365 (49%), Gaps = 28/365 (7%) Query: 1 MMKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M +T +I IPGDGIG E++ + VL A G ++ ++A + G + Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL----GSPFEWDS-QYAGMAAIARVGDPL 61 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P + + + G + T P ++ R+EF+ + N+RP Sbjct: 62 PRETIQSIHHNKLALKGPL----TTPTGGGYRSVNVQLRKEFELFANVRPA------LTL 111 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-HEVVIQESVFTRRGVDRILRYAFEL 177 + G + ++D ++REN +G Y++ + G + H V + TR G RI+RYAFE Sbjct: 112 IPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPER 236 A RK +T K+N L + E + +A+ Y I ++++ +D + V+ P R Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLVLDPGR 231 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V +NLFGDILSDL G +G+AP N+ + ++FE VHGSAPDI GK IAN Sbjct: 232 FDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIGKQ---AAIFEAVHGSAPDIAGKGIAN 288 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE-EVIAHGPKTPDMKGNATTPQVADAI 355 P+A + A AMMLD +G D + AI + G +TPD+ G A T ++ A+ Sbjct: 289 PLALMLAAAMMLDHVGKTD-----LATRLRNAIRITTLEDGIRTPDLGGTAKTRELTQAL 343 Query: 356 CKIIL 360 I Sbjct: 344 ISRIG 348 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 344 bits (883), Expect = 3e-93, Method: Composition-based stats. Identities = 129/351 (36%), Positives = 174/351 (49%), Gaps = 17/351 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + R+ +PGDGIG EV+ RV AAA R+G L +E+ G + Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRI-GAAAIREEGAPVSK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + + DA+ GAVG P+ + LL RRE + NLRPV P + P Sbjct: 60 ETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D +VRE T G Y + E SV+TR V+R+ R AFE A Sbjct: 120 LRPGVAEGVDLLIVRELTGGAYFG-----EKEEGEERASDLSVYTRGEVERVARVAFEAA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R + S K+N LA S W V +A +YP++ + +D V P RFD Sbjct: 175 RGR-RGRVASVDKANVLATSR-LWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRFD 232 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ NLFGDILSD G++G+ PSA+L E P +FEPVHGSAPDI GK +ANP Sbjct: 233 VILTENLFGDILSDEAAVLPGSMGMLPSASLG-EPGSPGIFEPVHGSAPDIAGKGVANPY 291 Query: 299 ATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 A I + AMM LG +A I +E +A G TPD+ G++ T Sbjct: 292 AAILSAAMMFRHGLGR-----PEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 343 bits (880), Expect = 6e-93, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 159/359 (44%), Gaps = 26/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG+E + + A + FE+++ E + + Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDVTGMEKNNKSSGDALHEAI 75 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P H S + R+E D Y +L ++ PG + Sbjct: 76 QSLKRNKVGLKGILFTPFEKGGHTSF---NVALRKELDIYASLVLIKNIPGFKT-----R 127 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++DF ++RENTEGEYS L + G VV + T RI ++AF+ A R Sbjct: 128 HDNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKIITEYKSKRIAQFAFDFALQNGR 183 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K++T K+N + ++ + +A Y I +D + V +P++FDV+V Sbjct: 184 KSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G ILS++G A G G+ P AN + +LFEP I G+ ANP A I Sbjct: 244 NLYGSILSNIGSALVGGPGVIPGANFGRDY---ALFEPGCRHVGLSITGRGEANPTAAIL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKIIL 360 + +ML LG + + I AA VI G T D+ G+A+T AI + + Sbjct: 301 SACLMLRHLG-----LKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 343 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 123/366 (33%), Positives = 183/366 (50%), Gaps = 31/366 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + ++ +PGDGIG EV+ + +L+A AE G +++ Y H + P+D Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISL----------WGSLLKFRREFDQYVNLRPVRLFP 113 + D I GAVGWP PD +++ R + D Y N+RPV+L P Sbjct: 69 ARCRGADVILLGAVGWPS--PDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLP 126 Query: 114 GVPCPLAGKQ-----PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVD 168 GV ++G + P +D ++RENTEG Y+ +GG++ G V + TRRG + Sbjct: 127 GVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCE 186 Query: 169 RILRYAFELAQSRPR-------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQ 221 RI+R AFEL + R R K +T K N L + E +A YP+I + Sbjct: 187 RIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVASEYPDIANELA 245 Query: 222 HIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP 281 +D V QPE +DV V +NLFGDI++DL G +G+A N+ E ++FEP Sbjct: 246 IVDAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEH---AMFEP 302 Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PK 338 +HGSAP + GK+ ANP+A + A L +LG D R + + + A+ V G P Sbjct: 303 IHGSAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPL 362 Query: 339 TPDMKG 344 T D+ G Sbjct: 363 TVDLVG 368 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 108/361 (29%), Positives = 176/361 (48%), Gaps = 13/361 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI +P DGIG E++ + VL++A + L+F+ + +G + D+ Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDV-GFTSLEKYGTTLRDEVLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + +D + G D FR D Y N+RP R P + + ++ Sbjct: 60 KAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNM--REG 117 Query: 125 GDIDFYVVRENTEGEY---SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D ++RE TEG Y + G ++ I TR +RI R AFELA R Sbjct: 118 RTMDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR 177 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 +K +T+ K+N ++ + E V +A ++PE+R D ID A V PERFDV+V Sbjct: 178 -KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 A+N +GDI+SDL +G++G+A S + + HGSAPDI G++ ANP++ I Sbjct: 237 ATNFYGDIISDLASELSGSLGLAGSMMASDTHC---CAQAQHGSAPDIAGQDKANPVSMI 293 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + AM++ ++G + A + AA++ V+ + +TPD+ GN + K+ Sbjct: 294 LSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKV 353 Query: 359 I 359 I Sbjct: 354 I 354 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 341 bits (876), Expect = 2e-92, Method: Composition-based stats. Identities = 117/382 (30%), Positives = 176/382 (46%), Gaps = 32/382 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M T +I +PGD IG E++ E I+VL + + HG + Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTT-DLVGGTSIDTHGVPIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPV-RLFPGV--P 116 + DA+ FG++G P+ H + LL+ R+ D + NLRP L P + Sbjct: 60 QSVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGA 119 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P+ F VVREN G Y E +V V+TR ++R+ R + Sbjct: 120 SPIREHVVKGTRFIVVRENCGGAYFGEKKE-----EEDVASDLWVYTRPEIERLARVSAA 174 Query: 177 LAQSRPRK-------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 +A+ R T+ SA K+N LA + + A+ +P+I Q D + Sbjct: 175 VARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSMAML 234 Query: 230 FVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHG 284 V P RF+ V+ N FGDILSD+ A TGT+G+ PSA+L ++EPVHG Sbjct: 235 MVRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHG 294 Query: 285 SAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG------PK 338 SAPDI GK +ANP+A I + AMML + ++ + A+ +V+ + Sbjct: 295 SAPDISGKGLANPVAQILSVAMMLRY----SMGLEKEATAVERAVVKVLDAKSEGGLEIR 350 Query: 339 TPDMKGNATTPQVADAICKIIL 360 T D+ G AT QV DA+C+++ Sbjct: 351 TGDLGGRATCSQVGDAVCEVLG 372 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 117/369 (31%), Positives = 181/369 (49%), Gaps = 19/369 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ +PGDGIG E + E +V+ E+ C Y HG+ + D Sbjct: 1 MASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGC-AYDAHGQAISDA 59 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E+ D++ FGAVG P D+VP + LL+ R++ Y NLRP +P + Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA++R R +TS K N + + + E + +++ + D + V P++ Sbjct: 180 LARTR-RNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV++ NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGNAT--T 348 IANPIA I + AM L + + + AAI V+ G +T D+ +GN T Sbjct: 299 GIANPIAMIASLAMCLRY----SFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGT 354 Query: 349 PQVADAICK 357 ++ DAI Sbjct: 355 TEMGDAILA 363 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 177/366 (48%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IA + GDGIG E+ +G+ V+ A E++G +++E + G P++ + Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYE-YAICGADAIDKVGDPFPEETYR 61 Query: 65 QLSRFDAIYFGAVGWPDTVPD---HISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPL 119 DA+ F AVG P D + LL R++ + N+RPV+ F + PL Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + DF +RE T G Y + +++ +++TR ++RIL+ FE A Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQ-----DNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RK LT K+N LA S W + + MA YPE+ D +D + + +P+ FDV Sbjct: 177 KR-RKHLTVVDKANVLASSR-LWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDV 234 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N FGDIL+D G +G++G+ PSA+ +FEP+HGS P G NIANP+A Sbjct: 235 MVTENTFGDILTDEGSVISGSMGLLPSASTGES---TPVFEPIHGSWPQAKGLNIANPLA 291 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADAI 355 I + AM+ ++ + I A++ + +TP++ T +V I Sbjct: 292 QILSVAMLFEYF-----DCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWI 346 Query: 356 CKIILR 361 I + Sbjct: 347 VDYIRK 352 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 120/346 (34%), Positives = 177/346 (51%), Gaps = 9/346 (2%) Query: 17 KEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL-SRFDAIYFG 75 V+ E +L+ ER G + +++ + Y G P+ + A+ G Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDL-GADRYLRDGTTFPNQIQIAIQRECSAVLLG 77 Query: 76 AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVREN 135 A+G P VP+ L R +D Y N+RPVR PL G+ DIDF V REN Sbjct: 78 ALGDPR-VPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFREN 136 Query: 136 TEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 TEG Y +GG+ GT EV I E V TR+GV+RI+R AF+ A++ R +T A KSN + Sbjct: 137 TEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMADKSNAM 196 Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 + W + YPEI+ + ++D LC + P +F V+V +NLFGDI++DLG Sbjct: 197 RHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGA 256 Query: 256 ACTGTIGIAPSANLNP-ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNG 314 A G +G+A SAN++ + +LFEPVHGSAP + GK+IANP A + ++L LG Sbjct: 257 ALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLG-- 314 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + I + + + G T D+ G T + + I Sbjct: 315 ---WPEEERRIERWVSQALDQGMCTVDVGGTLGTRAAGAWVREQIA 357 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 339 bits (871), Expect = 7e-92, Method: Composition-based stats. Identities = 96/352 (27%), Positives = 166/352 (47%), Gaps = 25/352 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP-DDWHE 64 + IPGDGIG E++ + + G + FE++ + + + ++ Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFR----HIGVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + R G + P L+ R D + N+ + PG+ + Sbjct: 108 SIKRNGVAMKGNIFTPLDAIPG--FRSLNLELRVHLDLFANIVRCKSIPGIQT-----RH 160 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ++D ++R+NTEGEYS L G V+ V T +I +YAF+ A+ RK Sbjct: 161 NNVDLVIIRQNTEGEYSHLEHENVSG----VIENLKVTTEEACMKIAQYAFDFAEKHDRK 216 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K+N + + + E M+ +YP I ++ ID C + V P++FDV+V N Sbjct: 217 KVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLPN 276 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIWA 303 L+G+I+S++G + G GI P N+ + ++FE + DI GK+I+NPI+ ++A Sbjct: 277 LYGNIVSNIGASLVGGPGIVPGENIGGDY---AIFESGSRHTGLDIQGKDISNPISMLFA 333 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 +ML+ L F + I +AI +V+ G T D+ G+ TT Q A+ Sbjct: 334 STLMLEHL-----EFTAYADLINSAILKVVQRGVLTADVGGSHTTTQFLSAL 380 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 339 bits (870), Expect = 9e-92, Method: Composition-based stats. Identities = 103/358 (28%), Positives = 168/358 (46%), Gaps = 34/358 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E R ++ + G + FE ++ + D Sbjct: 87 RYTVTLIPGDGIGPE----MARHVKTVLHKCGAPIDFEVIDI--------KDESSTDAAI 134 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 L R G + + P S+ + RR+ D Y N+ P + PGV + Sbjct: 135 ISLKRNGIGLKGTITTNISNPQSQSINA---QIRRKLDLYSNIVPCKSIPGV-----WTR 186 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G +D V+RENTEGEY SL +G VV + T + RI ++AF+ A R Sbjct: 187 HGQVDLVVIRENTEGEYGSLEHENVDG----VVESLKIITEKKSRRIAKFAFDYALQNNR 242 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 + +T+ K+N + ++ + E ++++Y +I ++ ID C + V P++FDV+V Sbjct: 243 RKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFDVMVMP 302 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+S +G G IG+ P N+ + ++FE D+ G N ANP ++ Sbjct: 303 NLYGNIVSHIGIGLVGGIGLVPGKNIGDKY---AIFESGARNIGSDLVGLNRANPCGFLF 359 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 A+ML LG + I +A+ I +G +TPD++G+ TT DA+ K I Sbjct: 360 TSALMLRHLG-----LDDYADIIESAVRTTIKNGKCRTPDIQGDRTTADFIDAVIKEI 412 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 338 bits (868), Expect = 1e-91, Method: Composition-based stats. Identities = 115/367 (31%), Positives = 178/367 (48%), Gaps = 18/367 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 IA +PGDGIG E++ + VL+ ER G F +E +Y G D+ Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLE-GGAAHYQKTGTAFSDEN 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + DA+ GA+G P + + L R E D Y LRP+R +P +P L K Sbjct: 65 MAACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDK 124 Query: 123 QPGDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + ID +VRE TEG YS G + + V + + +R G R+ +AF +A+ R Sbjct: 125 RASQIDLVLVREQTEGILYSRCRGTIEDDR---VAWETMMISRNGTSRVSEFAFRVAERR 181 Query: 182 PR-----KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 + + +SN L SM ++ +AE +P + D ++D + V P Sbjct: 182 AKSRRRPGKVLCVDRSNAL-TSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKSPWE 240 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V N FG ILSDL G++G+APSA++ + ++F+P HGSAP I G+ +AN Sbjct: 241 FDVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEKH---AVFQPAHGSAPHIAGQGLAN 297 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 P+A I + A+MLD+L +G+ R + A+E+ + + G T + A Sbjct: 298 PVAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALT-VVCPVEFGGKDGTAAITKA 356 Query: 355 ICKIILR 361 I I + Sbjct: 357 IIAQIRK 363 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 117/371 (31%), Positives = 168/371 (45%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E I+VL+A A F Q H + D Sbjct: 1 MATHNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 + DA+ GA+G P+ + LLK R+E Y NLRP Sbjct: 61 EALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + DF VVRE T G Y E ++R + RI R A Sbjct: 121 SPLKAEVCRGTDFIVVRELTGGIYFG---DRTEDDGSGYACDTEPYSRAEIVRIARLAGF 177 Query: 177 LA-QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA P + S K+N LA S + + +++ +P+++ + Q ID V P Sbjct: 178 LALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIY 290 + VV+ SNLFGDI+SD G+IG+ PSA+L + ++EP+HGSAPDI Sbjct: 238 ALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDIS 297 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP+ TI + AMML + + + + AA++ I +G KT D+ GNATT Sbjct: 298 GKGIVNPVGTILSVAMMLRY----SLNLPKEADAVEAAVKAAIDNGTKTKDLGGNATTSD 353 Query: 351 VADAICKIILR 361 + +A+ + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 126/356 (35%), Positives = 173/356 (48%), Gaps = 15/356 (4%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA IPGDGIG EV+ + VL A G + ++ + + Y G+ + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDAL----GLGTRTDILDHVNADTYLRTGEALTGSDLDR 76 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + +A GAVG P + D + G L R E D YVN RP RL+ PL Sbjct: 77 IRSSEAALLGAVGDPR-LGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARR 135 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ID +VRENTEG YS +GG GT E+ + + TR GV R+L +AF A R++ Sbjct: 136 AIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA----RRS 191 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N + W +P I ++D R P FDV+V +N Sbjct: 192 VCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNS 251 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL A G +G+A SANLNP T +LFEPVHGSAPDI G ANP I + A Sbjct: 252 YGDILSDLTAALAGGLGVAASANLNP-VTGRALFEPVHGSAPDIAGSGTANPFGAILSVA 310 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 ++ + LG +E +A G TPD+ G T +V A+ + R Sbjct: 311 LLAEHLGRNEEADAVRRAV-----AAAVAAGRVTPDLGGPLGTKEVGAAVLAELRR 361 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 152/349 (43%), Positives = 202/349 (57%), Gaps = 17/349 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A IPGDGIG EV+ EG++VL+A A + + + G+++PD + Sbjct: 1 MRLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDL-GASRWQRTGELLPDTVLD 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L R DAI GA+G +VP I G LL+ R E D +VNLRP RLF GV PLA P Sbjct: 56 ELRRHDAILLGAIG-DPSVPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAA--P 112 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 G ID VRE TEG Y GG + T HEV + S+ T GV+R++RYAFE A +RPR+ Sbjct: 113 GAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALARPRR 172 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT K+N L + W VE ++ +PE+ QH+D FV P RFDV+V N Sbjct: 173 HLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVIVTDN 232 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDI++DL A TG IG+A S NL+ T PS+FEPVHGSAPDI GK +A+P AT+ + Sbjct: 233 LFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSV 292 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVAD 353 ++LD LG D+ + AA+ ++ T D + T V D Sbjct: 293 GLLLDHLGRADQ-----ARKVNAAVAFDLS----TRDPEAQVRTEDVGD 332 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 119/361 (32%), Positives = 176/361 (48%), Gaps = 17/361 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I + GD IG E++PE +RV+QAAA R G A+ ++ + G +PD E Sbjct: 1 MKIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPI-GRAALDSLGSTLPDGTIE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L D G +G P R+ FD + N+RPV+ +PC Sbjct: 60 RLDALDGWLLGPIGHMAY-PKIPEAINPHPLLRKHFDLFANIRPVKSHAALPC-----LH 113 Query: 125 GDIDFYVVRENTEGE---YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D +VREN EG + + G +V I V TR G ++ R AFELA++R Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFELARAR 173 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ LT+ K + + E +A YP++ +D+ +D R VM P+R+DVVV Sbjct: 174 -RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYDVVV 232 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDIL+D G +G+A P ++ + HGSAPDI G+ IANP A I Sbjct: 233 TTNMFGDILTDEAAGLVGGLGMAAGLCAGPRH---AMAQATHGSAPDIAGRGIANPYAMI 289 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKI 358 +G M+LD+LG A I A+ +I TPD+ G TT + AI + Sbjct: 290 MSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQGTTAGMGSAIIEA 349 Query: 359 I 359 + Sbjct: 350 M 350 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 100/362 (27%), Positives = 165/362 (45%), Gaps = 33/362 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ GDG+G E++ + ++ A G + + +E Y + D E Sbjct: 3 KLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWET 58 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L R + + T P + + R++ + N+RP + L + P Sbjct: 59 LKRNKVLLKAPI----TTPRGGGVRSLNVTLRKKLGLFANIRPCK------SHLEWQDPK 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D ++REN E YS + R T + V T +RI RYAFE A+S RK Sbjct: 109 -MDIVIIRENEEDLYSGIEYRQTLDTYN----CTKVITESTSERICRYAFEYARSNGRKK 163 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K N + ++ + + + +A YP+I + IDI AR PE+FDV+V NL Sbjct: 164 VTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNL 223 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDI+SD+ +G++G+ S N+ E ++FE VHGSAPDI ++IANP + A Sbjct: 224 YGDIISDIAAEISGSVGLGGSINIGEEY---AMFEAVHGSAPDIADQDIANPSGLLNAAM 280 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVADAICKII 359 ML ++G ++ + +A + + G T D+ K T + + I I Sbjct: 281 YMLSYIGQ-----KEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 Query: 360 LR 361 R Sbjct: 336 DR 337 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 336 bits (863), Expect = 5e-91, Method: Composition-based stats. Identities = 115/372 (30%), Positives = 180/372 (48%), Gaps = 21/372 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T ++ +PGDGIG EV+ E R++ + + E Y + D Sbjct: 1 MATHKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEH-GLVGGAAYDADKVAITDA 59 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 DA+ FGAVG P D VP LL+ R++ + NLRP +P + Sbjct: 60 TMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + + G + I V+ ++RI R AF+ Sbjct: 120 SLKPEVVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AENYPEIRWDKQHIDILCARFVMQPE 235 LA+ R R +TS K N + + W+E + + A Y +++ + Q D V P+ Sbjct: 180 LARKR-RNKVTSMEKRNVMK-TGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPK 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYG 291 +FDV+V NLFGD+LSD+ TG++G+ PSA+L +++EPVHGSAPDI G Sbjct: 238 QFDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----T 347 K +ANP+A + + M L + + + + AI V+A G +T D+K + Sbjct: 298 KGLANPVAMLASFGMALRY----SLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVS 353 Query: 348 TPQVADAICKII 359 T Q+ +AI + + Sbjct: 354 TSQMGEAIVQEM 365 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 336 bits (861), Expect = 9e-91, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 160/359 (44%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +A + GDG+G E+L V Q G + FE++ D Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEV-----AVNQESEDATFTDAL 118 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + R + Y ++ R FPGV + Sbjct: 119 LAMKRNGVGIKGNFATEP------GQSSRNVALRLNLNLYAFVQRCRNFPGVVT-----R 167 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS L G VV + TR RI ++AF+ A R Sbjct: 168 HQNVDIVIIRENTEGEYSRLEHENVPG----VVESLKIITREKSTRIAQFAFDYAVRHNR 223 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + ++A+NYP+I ++ ID C + V +P++FDV+V Sbjct: 224 KKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFDVIVLP 283 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ NL P+ +LFE S + GKNIANP + Sbjct: 284 NLYGNIVGNVAAGLVGGAGLTTGINLGPQN---ALFEMGTRNSGRSLAGKNIANPCGMLL 340 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A ML++LG+ E I ++ +VI +T D+ G+ T +V +A+ K + Sbjct: 341 TSADMLEYLGHIKE-----AKLIRDSVVDVIGEQKIRTADLGGSFKTSKVIEAVLKSLR 394 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 336 bits (861), Expect = 1e-90, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 173/355 (48%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RIA IPGDG+G E++ I VL+ ++ L E A E G +P++ Sbjct: 3 RIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFE-AGDETKRKRGVALPEETLNG 61 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA A+G S +L R++ D YVNLRP + +P + Sbjct: 62 VMNSDATLMVAIG--------ESAREVILPLRQKLDLYVNLRPAKSYP------VPRAIP 107 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D +VRENTE Y G R + + + TRR +RI R+ + A+ R + Sbjct: 108 GFDLTIVRENTEDLYVMSGWR-----GLDTAVDLRIITRRASERICRFGYRYARERGKSR 162 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N L M + E +AE + + ++D R M FDV++ +N+ Sbjct: 163 VYVVHKANVLGGCM-LFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVIITTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSDL A G +G+ PSAN+ R ++FEPVHG+AP+I GKNIANP+ATI + A Sbjct: 220 FGDILSDLAAAFIGGLGMYPSANIGESR---AIFEPVHGTAPEIAGKNIANPMATILSAA 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MM+ +LG+ I A+ G TPD+ G+ T +V I +I+ Sbjct: 277 MMMGWLGHEG-----GSKLIEEAVRRACELGYTTPDVGGSMRTKEVGLKISEIMR 326 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 97/357 (27%), Positives = 160/357 (44%), Gaps = 36/357 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPG GIG E+ V +A + F+ ++ + E DD Q Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL----HVPIKFDVLDNFNFEN---------DDSKSQ 80 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L + + I G + + + KF + D Y N+ G+ ++ Sbjct: 81 LRKNECILLGVMTEKNQK------YTDNYKFYKYLDLYSNITFAFSVEGIT-----QRHN 129 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 + D V+RENTEGEYS + V G VV V T++ RI YAFE A R+ Sbjct: 130 NTDIVVIRENTEGEYSGVEHEVYPG----VVESIKVTTKQASLRIAEYAFEFAHLSGRRK 185 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A+ Y I++++ ID C + V P +FDV+V NL Sbjct: 186 VTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVMVMPNL 245 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +G I+ ++ TG +G+A A++ + S + + DI GKN+ NP A + + Sbjct: 246 YGSIVQNVVAGITGGVGMAAGASIGKDHALFS--QGCRHTGRDIAGKNVVNPSAMLVSST 303 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 ++L LG + I A++ I KT D+ GNATT Q + + + R Sbjct: 304 LLLRHLG-----LPNFADQICRAVQHTIQDKKIKTKDIGGNATTDQFTSEVIRSLGR 355 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 333 bits (853), Expect = 9e-90, Method: Composition-based stats. Identities = 99/359 (27%), Positives = 158/359 (44%), Gaps = 32/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDG+GKE+ + +A ++W + K + Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA---------ENIPIDWETINIKQTDHKEGVYEAV 78 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E L R G P D + R++ D Y N+ + GV + Sbjct: 79 ESLKRNKIGLKGLWHTP---ADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP--- 132 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID V+RENTEGE+S L G VV V TR +RI R+AF+ A+ R Sbjct: 133 --DIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRPKTERIARFAFDFAKKYNR 186 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K++T+ K+N + + + + + + YP+I +D + V +P +FDV+V Sbjct: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +++G IL ++G A G G+ AN + ++FEP DI G+N+ANP A I Sbjct: 247 PSMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEPGSRHVGLDIKGQNVANPTAMI 303 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + +ML+ LG + I A+ E IA G T D+ G+++T + I + Sbjct: 304 LSSTLMLNHLG-----LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 330 bits (847), Expect = 5e-89, Method: Composition-based stats. Identities = 108/379 (28%), Positives = 169/379 (44%), Gaps = 26/379 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 +T +I +PGDGIG EV+ E RVL+ A + E ++ C HG+ + Sbjct: 4 RTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCS-IDKHGEPLTAA 62 Query: 62 WHEQLSRFDAIYFGAVGWPDT-VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP---C 117 E DAI GA+G P V + +LL R+ Y N+RP Sbjct: 63 TLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLLAYS 122 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PL +D V+RE G Y + + + +++ V RI R ++ Sbjct: 123 PLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSRRQV 182 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A P + S K+N LA S + E + +P+++ D +D V P++ Sbjct: 183 ASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANPKKL 242 Query: 238 D-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPS----------LFEPVHGSA 286 + V++ NLFGDILSD G++G+ PSA+L +P+ ++EP+HGSA Sbjct: 243 NGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIHGSA 302 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV-----IAHGPKTPD 341 PDI G+ IANPI TI + AM L ++ I AA+E G +T D Sbjct: 303 PDIAGQGIANPIGTILSAAM----LCGTRSVWRSPAKAIEAAVEGARRQGDRREGLRTAD 358 Query: 342 MKGNATTPQVADAICKIIL 360 + G++ T + + +I+ Sbjct: 359 LGGSSKTKDIGHKVVEILK 377 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 103/363 (28%), Positives = 168/363 (46%), Gaps = 30/363 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDG+G E++ + +L+ A +S E ++ +Y + Sbjct: 7 SVPITVAYGDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAPSAW 62 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E +SR + P + R+ YVN+RP + P+ G + Sbjct: 63 ESISRTRLLLKAPTMT----PQGSGHKSLNVALRQRLGLYVNVRPCVSY----FPVVGTK 114 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 D+D ++REN E YS + +++E T V + TR ++I YAF A++ R Sbjct: 115 HPDLDVVIIRENEEDTYSGVEHKLSEDTHECV----KISTRSASEKICAYAFNYARAHNR 170 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T K N + ++ + +A+ YP+I + +D+ A+ PE FDVVV + Sbjct: 171 KKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVVVTT 230 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SD+ +G+IG+ SAN+ ++FE VHGSAPDI GKN+ANP + A Sbjct: 231 NLYGDIVSDIVSLSSGSIGLTGSANIGDYY---AMFEAVHGSAPDIAGKNVANPSGLLNA 287 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK------GNATTPQVADAICK 357 ML +G D+ I A + + G T D+ A+T + A AI Sbjct: 288 AVQMLVHIGQLDK-----AGVIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIVG 342 Query: 358 IIL 360 + Sbjct: 343 NLG 345 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 112/356 (31%), Positives = 173/356 (48%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRIA I GDG+G E++ + +L+ F +++ A Y+ GK + D+ E Sbjct: 1 MRIAVIKGDGVGPEIMGATLSLLE-----RYIGADFIEIK-AGKSYFIEEGKPIEDNAIE 54 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D++ G V P P + S+ RREF Y N+RP R + G+ Sbjct: 55 KIRECDSLLKGPVATPTKGPSYPSVNTL---LRREFKLYANVRPFRSYEGISI------- 104 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID +VREN E Y + + I V T+RG +RI +AF LA+ R Sbjct: 105 RRIDTILVRENLECLYYGWEVE-----DEDRAIAMRVITKRGAERISEFAFNLAKREGRG 159 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K N L + + + +A + ++R D + +D + V FDV++ N Sbjct: 160 RVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVMLTPN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSD+ G+IG+ SA + + + FEP+HG+ DI GK +ANPI I A Sbjct: 219 LYGDILSDVAAGVVGSIGLCGSAQIGED---FAAFEPIHGTGEDIAGKGVANPIGMIIAA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +MMLD+L R + I A++ VI TPD+ G+ T QV + I + Sbjct: 276 SMMLDWLWERG-RSPKRGEKIREAVDSVIRDRILTPDLGGDFRTEQVVEKIVDRLR 330 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 94/361 (26%), Positives = 160/361 (44%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PGDGIG E + ++Q + FE+ + S P+ Sbjct: 44 RHTVTLLPGDGIGPE----MLDIVQKIFTFANVPVDFEECQLDSK-------PTSPESDL 92 Query: 64 E-QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G +T D ++ RR D + N+ P +P Sbjct: 93 DNAIMSIQRNGVAIKGNIETKYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPT----- 147 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + I+ ++RENTEGEYS G VV + TR ++RI R+AF+ A + Sbjct: 148 RHKGINIVMIRENTEGEYSGHEHETVNG----VVESLKICTREKLERISRFAFDYAIAHN 203 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T+ K+N ++ + + V +A + YP I +D +D + V +P++FD+++ Sbjct: 204 RKKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQFDIML 263 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIAT 300 NL+G+I+S++ G G+ N+ + ++FE + I G++IANP A Sbjct: 264 MPNLYGNIISNIACGLVGGPGLVSGMNIGDKY---AVFETGTRNTGSGIAGQDIANPTAF 320 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKII 359 I AG ML +LG + N I A+ + I T D+ G A T V +A+ + I Sbjct: 321 IRAGVDMLHYLG-----LTEYANLISDALFDAIVIKRLHTKDIGGTAKTSDVVNAVMRNI 375 Query: 360 L 360 Sbjct: 376 E 376 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 326 bits (837), Expect = 6e-88, Method: Composition-based stats. Identities = 114/361 (31%), Positives = 166/361 (45%), Gaps = 31/361 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI + G+GIG E+ IRV++A G ++ + A E +G +P + Sbjct: 1 MRIGVLKGNGIGPEITAATIRVIEA----TGIQPEWDFIPIA-DEAVRLYGHALPPQVIQ 55 Query: 65 QLSRFDAIYF---------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 ++ G + T ++ RRE + +VN RP+R + G+ Sbjct: 56 RIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGI 115 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +D ++RE TE Y + +G E + TR ++ +YAF Sbjct: 116 S-----GRHEKMDMVIMREITEDTYIGWEKPLEDGAAAEAI---KRVTRSASWKVSQYAF 167 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+ RK ++ K+N L + + + +A YP+I D ID C V P Sbjct: 168 EYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPC 227 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDVVV N +GDI SDL G++G+AP AN+ S FE HG+APDI G A Sbjct: 228 WFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDS---ASTFEAAHGAAPDIAGTGAA 284 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADA 354 NPIA I +GA +L G G + I A+ VI G TPD+ G +TT QVADA Sbjct: 285 NPIALILSGAELLAHAGYG-----KGSEAIREAVTRVIEAGRTLTPDLGGRSTTEQVADA 339 Query: 355 I 355 I Sbjct: 340 I 340 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 326 bits (837), Expect = 7e-88, Method: Composition-based stats. Identities = 112/370 (30%), Positives = 179/370 (48%), Gaps = 21/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG E + E +++ E ++ C Y HG + + Sbjct: 1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGC-AYDAHGAAISEA 59 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC-- 117 ++ DA+ FGAVG P D+VP + LL+ R++ + NLRP +P + Sbjct: 60 DMQKALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NYPEIRWDKQHIDILCARFVMQPE 235 +A++R + S K N + S W++ V + Y +++ + D + V QP+ Sbjct: 180 MARTRQ-NRVCSMEKRNVMK-SGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPK 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYG 291 +FDV+V NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI G Sbjct: 238 QFDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----T 347 K IANPIA I + AM L + + + + AI V+ G +T D+ + Sbjct: 298 KGIANPIAMIASFAMCLRY----SFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVG 353 Query: 348 TPQVADAICK 357 T ++ +AI Sbjct: 354 TVEMGEAILA 363 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 97/358 (27%), Positives = 163/358 (45%), Gaps = 32/358 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD-WHEQ 65 + +PG GIG E +R ++A + FE + ++ G D + Sbjct: 50 VTLLPGHGIGPE----MMRHVEAIFACGKVPVDFETI-----IVDANVGDASSMDHAIKS 100 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R G + +T +++ L R + + YVN+ R PG+ + Sbjct: 101 IRRNGVALKGNI---ETTSYSMTVEPRNLLLRNKLELYVNVVHCRNHPGI-----NTKHK 152 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D V+R+NTEGEYS L V G VV + T +I +Y FE A++ RK Sbjct: 153 GVDIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYCFEYARTHMRKK 208 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K+N + ++ + + +A+ YP+I + ID C + V P +FDV++ NL Sbjct: 209 VTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDVMLVPNL 268 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIWAG 304 +G+I+ ++ G G+ N E ++FE + + GKN+ANP+AT++A Sbjct: 269 YGNIVVNVACGLVGGAGVTSGRNYGKEY---AVFETATRNTGTPLVGKNLANPVATLYAA 325 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIILR 361 ML L D I AIE+ + T D+ G+ATT +V + I K + + Sbjct: 326 VDMLKHLELWD-----HAVVIRRAIEKTVNRDKVHTKDLGGDATTSKVVENILKEVQK 378 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 326 bits (836), Expect = 8e-88, Method: Composition-based stats. Identities = 110/370 (29%), Positives = 175/370 (47%), Gaps = 18/370 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 +K +I +PGDGIG EV+ E +V+ ++ + A Y HG + D+ Sbjct: 4 IKKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDE-DLAGGCSYDKHGTPITDE 62 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + + + GAVG P D + +LLK R+E + NLRP F + Sbjct: 63 VFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDAS 122 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-VIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + E I +T + R+ + AF+ Sbjct: 123 TLKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFD 182 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R +TS KSN + + +E E + Y ++ D + + P++ Sbjct: 183 LARKRS-NRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQ 241 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V NLFGD+LSD TG++G+ PSA+L + +++EP+HGSAPDI GK Sbjct: 242 FDVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKE 301 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 IANPIA+I + AM L + + + A+++V+ G +T D+ K +T Sbjct: 302 IANPIASILSFAMALRY----SLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTS 357 Query: 350 QVADAICKII 359 + DAI + Sbjct: 358 AMGDAIISKL 367 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 106/369 (28%), Positives = 166/369 (44%), Gaps = 34/369 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG+E++ ++A G + +EQM+ E + G + D Sbjct: 32 QAHTVLTFDGDGIGREIVSAAKECIEA----TGVNIRWEQMD-MGYEAMQNTGVYIDDSH 86 Query: 63 HEQLSRFDAIYFGAVGWPDTVPD------HISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 + ++ G + P + FR+ F + N+RPVR PGV Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P D+D V+RENTE Y+ V+ T H V +R +R+ ++F+ Sbjct: 147 APF-----NDVDLVVIRENTEDVYTGEETWVDADTVHCV----KRISRGASERVADFSFK 197 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEA--MAENYPEIRWDKQHIDILCARFVMQP 234 A+ RK +T+ K+N S + A + I D Q D + +++P Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLMIEP 257 Query: 235 ERFDVVVASNLFGDILSDLG----PACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 + FDV+ NL+GD+++ L G++G+ PS N+ T +LFEP HGSAPDI Sbjct: 258 KSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG---THQALFEPAHGSAPDIA 314 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK IANP + I +G MML LG +A + A+ + A G D G A T + Sbjct: 315 GKGIANPTSQILSGCMMLSHLGEF-----EASQRLENALRAMYASGIVPVDFGGQADTKE 369 Query: 351 VADAICKII 359 V A+ K + Sbjct: 370 VVAAVLKHL 378 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 110/372 (29%), Positives = 179/372 (48%), Gaps = 18/372 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ +PGDGIG EV+ + R++ + + Y HG P + Sbjct: 1 MAAKKLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGG-AAYDVHGTPYPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E DA+ GAVG P D +P LL R++ + NLRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y ++ V+T + RI R AF+ Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R K L S K+N L ++ + +E ++ E +P++ ++D + V P++ Sbjct: 180 LARKRN-KKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYGKN 293 FDV+V N+FGDILSD TG++G+ PSA+L + +L+EPVHGSAPDI GK+ Sbjct: 239 FDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKD 298 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 +ANP+ATI + AM L + + I A++ V+ G +T D+ K +T Sbjct: 299 MANPLATIMSFAMCLRY----SFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTT 354 Query: 350 QVADAICKIILR 361 + +A+ + + + Sbjct: 355 VMGEAVVRELDK 366 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 117/387 (30%), Positives = 165/387 (42%), Gaps = 52/387 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M RI +PGDGIG EV+ + V+ A + + + G+ +P Sbjct: 5 MLRKRICVLPGDGIGIEVMEAALPVIAAL----NLPFDLVPADI-GWQCWRAEGETVPAR 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVR 110 E ++ DA GA+ + +++ R+ D Y N+RPV Sbjct: 60 TWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVT 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSL-------------------GGRVNEGT 151 G F V+RENTEG Y+ L G Sbjct: 120 DMTG---------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + + + + TR G+ RI YAFE A+ +T K L S + EA A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP++ +++D + V +PERF V+VA N+FGDILSDLG G +G APS N Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 + FEPVHGSAP G N ANP A A A+ML+ LG E I A+ Sbjct: 291 SG---AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFPTESA-----CISQAVSL 342 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKI 358 V +T D+ G+ TT QV +AI + Sbjct: 343 VSRTSTRTYDLGGSHTTAQVGEAIVQQ 369 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 114/361 (31%), Positives = 175/361 (48%), Gaps = 15/361 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I +PGDGIG E++ +RVL+AA++R+ L + A HG + E Sbjct: 1 MKIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIGH-DIAGHASLQRHGATVTPALLE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D + G + D + FR+E D Y N+RP R FPG+ + Sbjct: 60 KVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMA-----HRV 114 Query: 125 GDIDFYVVRENTEGEYSSL---GGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G+ + VVRENTEG Y+ G + VI TR +RI R AF+LA++R Sbjct: 115 GEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDLARTR 174 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R ++ K+N L I + + +A +P++R D +D + A V P+RFDV+V Sbjct: 175 AR-HVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFDVIV 233 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDILSDL +G++G+ S N + ++ + VHGSAPDI G+NIANP + I Sbjct: 234 TTNMFGDILSDLTAELSGSLGLGGSLNAGKDH---AMGQAVHGSAPDIAGRNIANPYSLI 290 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + +L + G F A I + T D G T + + + + Sbjct: 291 LSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRDAGGELGTAEAGQSFVRRL 350 Query: 360 L 360 L Sbjct: 351 L 351 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 324 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 115/374 (30%), Positives = 178/374 (47%), Gaps = 20/374 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +I + GDGIG EV+ + RV+ + A E Y G + D Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGG-AAYDAQGTPLHD 59 Query: 61 DWHEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 D DA+ GAVG W ++P + LL+ R++ + + NLRP +F + Sbjct: 60 DTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAE 119 Query: 117 -CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-VIQESVFTRRGVDRILRYA 174 L + +D +VRE T G Y ++ E + V+ + R+ + A Sbjct: 120 ASTLKTELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKVA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LA R K L S K+N + S W E V + +YPEI + D + V QP Sbjct: 180 FDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 ++FDV+V NLFGDILSD TG++G+ PSA+L +++EPVHGSAPDI G Sbjct: 238 KQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM---KGNA-T 347 ++ ANP+ATI + +MML + + + + A+ V+A G +T D+ Sbjct: 298 QDKANPLATILSFSMMLRY----SFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVG 353 Query: 348 TPQVADAICKIILR 361 T + DA+ + + Sbjct: 354 TTGMGDALLAEMAQ 367 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 324 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 91/358 (25%), Positives = 159/358 (44%), Gaps = 27/358 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ IP DGIG+ ++ + V Q G + FE+ +D Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKSF--NDIK 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G I + R + D Y N+ + +P V + Sbjct: 99 TSVLRNGTALKGNWATSM----GIDSKSYNVLLRHDLDLYANVVKFKSYPTVIT-----R 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D V+RENTEGEY++L G V+ + T++ +RI +YAF+ A R Sbjct: 150 HNNVDLIVIRENTEGEYTNLEHENIPG----VIEMIKIITKKKSERIAKYAFDYAMENNR 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + + + +AE YPEI ++ ID + V +PE+FDV+V Sbjct: 206 KKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFDVIVTP 265 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+G++LS++ A G G+ N S DI KNIANP++ ++A Sbjct: 266 NLYGNVLSNIAAALVGGPGLPHGENHGNGIHV--FESGTRNSGMDIATKNIANPMSMLFA 323 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 +L L + + I + I +++ + +T D+ GN +T + + + K + Sbjct: 324 ATALLRHL-----QLSKHAQLIESCIHKIVTTNQARTVDIGGNTSTSEFFEILVKEVE 376 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 324 bits (830), Expect = 4e-87, Method: Composition-based stats. Identities = 109/381 (28%), Positives = 164/381 (43%), Gaps = 36/381 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+T + +PGDG G E++ VL AA GF + ++ + A + ++PD Sbjct: 1 MRTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWDVHQ-AGQRALAESESLLPDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + A G T P + R+E D Y LRPVR P + Sbjct: 60 TLNSIRTNGAALKGPT----TTPIGTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEE 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLG---------------GRVNEGTEHEVVIQESVFTRRG 166 + +D VVRENTE Y+ L G + + + FT G Sbjct: 115 PERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPFTPHG 174 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +R++ +AF A RK + S + + + +A +P I + L Sbjct: 175 CERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVPVPAL 234 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 CA V P R DV+V NL+GDI+SD+ A G++G+AP AN+ ++FE HGSA Sbjct: 235 CADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAHH---AVFEATHGSA 291 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDM--- 342 P+ G NP A I++G M+LD LG + I AA+E+V+A G T D+ Sbjct: 292 PEFAGSGRLNPTALIFSGCMLLDHLGE-----HETAARIRAAVEDVVAAGEVLTFDLLAP 346 Query: 343 ---KGNATTPQVADAICKIIL 360 ATT + A+ + Sbjct: 347 QRSADAATTVEFTRAVTDRLG 367 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 323 bits (827), Expect = 8e-87, Method: Composition-based stats. Identities = 130/384 (33%), Positives = 190/384 (49%), Gaps = 42/384 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ RI IPGDGIG EV + ++V++AA +GF+L + E+Y +++PD Sbjct: 1 MKSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPY-GAEHYLSTRQVLPDH 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E++ DA+ GA+G P P I G LLK R FDQY N+RPVR F P PL Sbjct: 60 ALEEMEGLDALLLGAIGDPRVQP-GILERGILLKLRFHFDQYANIRPVRSF--TPGPL-- 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG----------RVNEGT-------------EHEVVIQ 158 G ++ V+RENTE Y +G V G +Q Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T G R +YAF+LA + +T ATKSN + ++ +A Y + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++D LC + V P F V++ N+FGDI+SDL G +G+APS N+ S+ Sbjct: 232 RVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDR---LSM 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 FEPVHGSAPDI G++ ANP+A+I +GAM+L LG A + A++ ++ Sbjct: 289 FEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETS-----AAKAMEDAVQRYLSGPVE 343 Query: 338 -KTPDMKGNATTPQVADAICKIIL 360 +M G T DA+ + + Sbjct: 344 ELPIEMGGRLGTRGAGDAVVRRLE 367 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 145/386 (37%), Positives = 201/386 (52%), Gaps = 37/386 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++ ++A +PGDGIG EV+ L+A G AL ++ W + ++ HG+MMP DW Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEALP---GPALVLTELGWPAHAWHRDHGEMMPADW 62 Query: 63 HEQLSRFDAIYFGAVGWPD--------TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 QL+ +DA+ GA+G P +PD +SL LL+ R+ D + RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSL-APLLQLRKGLDLWACERPAVPLAG 121 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 P PL+ + D V+REN+EGEY GGR+ GT E Q VFTR G +RI+R+A Sbjct: 122 APMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHA 181 Query: 175 FELAQS---------RPRK----------TLTSATKSNGLAISMPYWDERVEAMAENYPE 215 FE A R + + TK N + + W E +A YP Sbjct: 182 FERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPG 241 Query: 216 IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP-ERT 274 I + ID C +FV QP +FDVVVASNL GDIL+DL G +G+APSANLNP +R+ Sbjct: 242 IATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRS 301 Query: 275 FPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 P LFEP HGSAPDI G + A+P A + A ML+++G D ++ + A+ E IA Sbjct: 302 VPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIA 361 Query: 335 HGPKTPDMKGNATTPQVADAICKIIL 360 M G +V A+ + I Sbjct: 362 EHG----MGGR-GCAEVGRAVAQRIR 382 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 126/356 (35%), Positives = 173/356 (48%), Gaps = 37/356 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+A IPGDGIG EV+ +RVL+A R + FE E + + G + ++ E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYE-GGVDVFQECGSPIREEDLE 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ R DA+ FGA P +P + +L R+E Y NLR + P + Sbjct: 57 EIRRSDAVLFGATTTPFDLPGY---RSLILTLRKELGLYANLR---IIPDLRT------- 103 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + +VREN+EG Y +G VN + + TR G +RI R+A E A++R Sbjct: 104 -GREIVIVRENSEGLYFGIGAVVN-----GRAVDVRLITREGAERIARFAVEQAKARG-S 156 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K+N L ++ V +A + ID + V P V+++ N Sbjct: 157 FITFVHKANVL-TGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVILSEN 214 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSDL G+IGI PS N +LFEPVHGSAPDI GK IANPI I +G Sbjct: 215 LFGDILSDLATVHAGSIGIVPSGNYGD---GIALFEPVHGSAPDIAGKGIANPIGAILSG 271 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AM+LD+LG I AA+ + +G TPDM G A T V I I Sbjct: 272 AMLLDYLGLDGS-------LIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIE 320 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 318 bits (816), Expect = 1e-85, Method: Composition-based stats. Identities = 88/357 (24%), Positives = 163/357 (45%), Gaps = 25/357 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + +PGDG+G E++ V +AAA + F++ + + + K+ + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL--EQVL 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P ++ + ++ RR+ D + N+ V+ PG + Sbjct: 102 SSMKENKVAIIGKIHTPMEYKGELASYD--MRLRRKLDLFANVVHVKSLPGYMT-----R 154 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RE TEGEYSSL G V+ + TR RI ++AF+ A + R Sbjct: 155 HNNLDLVIIREQTEGEYSSLEHESARG----VIECLKIVTRAKSQRIAKFAFDYATKKGR 210 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T+ K+N + + + + E +AE YP+I+++ ID C + V P +FDV+V Sbjct: 211 GKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ +L G G+ P + + E ++FE G+NIANP A + Sbjct: 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEY---AVFETGARHPFAQAVGRNIANPTAMLL 327 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + ML L N + + + + + +T DM G +TT ++ + Sbjct: 328 SASNMLRHL-NLEYHSSMIADAVK---KVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 380 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 317 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 108/390 (27%), Positives = 176/390 (45%), Gaps = 52/390 (13%) Query: 2 MKT---MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 MK+ ++IA +PGDGIG EV + V + L++ + W E++ G + Sbjct: 1 MKSTDPIKIAVLPGDGIGIEVTEATLPVFEVLD--VPVILNYGDIGW---EFWKKEGAAI 55 Query: 59 PDDWHEQLSRFDAIYFGAVGWPD-----------TVPDHISLWGSLLKFRREFDQYVNLR 107 P + ++ D + GA+ + +++ R+ D + N+R Sbjct: 56 PSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVR 115 Query: 108 PVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH-------------- 153 P P +F ++REN+EG Y H Sbjct: 116 PCFSIDDQSKPF--------NFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPA 167 Query: 154 -EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN 212 E + ++ G+ R+ +AF+ A +T A K N L S + + E+ A+ Sbjct: 168 DEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQR 227 Query: 213 YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 YP+I+ D ++D + + PE+F V+VA N+FGDILSD+G G +G+APSAN+ + Sbjct: 228 YPKIQADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDK 287 Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV 332 ++ FEPVHGS P I KN ANP A +M+L+ G D I+ A+ +V Sbjct: 288 GSY---FEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPDR-----AKKIVNAVMQV 338 Query: 333 IAHGP-KTPDMKGNATTPQVADAICKIILR 361 I T D+ G+ATT +A+A+ + R Sbjct: 339 IKEKRFITYDLGGHATTTDMANAVIEHCAR 368 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 317 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 113/406 (27%), Positives = 173/406 (42%), Gaps = 66/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK--MMPDDWHE 64 I I GDGIGK+V P +VL+AAAE G +S+ ++ +A +G+ +PD+ + Sbjct: 33 IPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRV-YAGESAREEYGEDVNLPDETVD 91 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G + T P + R+ D Y N+RP GVP P+ P Sbjct: 92 AIREHRVAIKGPL----TTPVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPMKA--P 145 Query: 125 GDIDFYVVRENTEGEYSSLGGR--------VNEGTEHEVVIQE-----------SVFTRR 165 ++D RENTE Y+ + V E E E+ E T + Sbjct: 146 EEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPITEK 205 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE--------- 215 G R++R A + A R +T K N + + + + +A E YP+ Sbjct: 206 GSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVFAAPDS 265 Query: 216 --------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTI 261 + +++ D + ++ + FD++ NL GD LSD A G + Sbjct: 266 LWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLSDAAGAQIGGL 325 Query: 262 GIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQA 321 GIAP N R L EPVHGSAP G+++ANP A I +G +M D+LG + A Sbjct: 326 GIAPGGNFGKGRM---LAEPVHGSAPKRAGQDMANPTAMILSGRLMFDYLG-----WDDA 377 Query: 322 HNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADAICKIILR 361 + I A+EE I+ G T D++ T + D I I + Sbjct: 378 ADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 119/408 (29%), Positives = 179/408 (43%), Gaps = 62/408 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG +VLP+ IRVL+A GF ++ + E + + G +PD Sbjct: 1 MARPTVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADI-GWECWCNEGNALPDR 55 Query: 62 WHEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 + L + FGA+ P+ +S + ++ R+ F+ V +RP Sbjct: 56 TIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCL 115 Query: 111 LFPGVP------CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT------------- 151 FPG P G + +D V R+NTEG Y+ + Sbjct: 116 SFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAA 175 Query: 152 -----EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 E+ + + T++ RI AF+ A+ K +T K N L + +E Sbjct: 176 FANTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVA 235 Query: 207 EAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 + + + YPEI +ID PE + V+VASNLFGD++SD G +G A S Sbjct: 236 KQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAAS 295 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKN--IANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 N+ E ++FEP HGSAP N I NPIA I + AMMLD +G ++ + Sbjct: 296 GNIGDE---VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHIGESEK-----ADR 347 Query: 325 ILAAIEEVIAHGP-KTPDM-----------KGNATTPQVADAICKIIL 360 I AI +V+ G +T DM +G A T Q+ DAI + Sbjct: 348 IRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVE 395 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 314 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 131/370 (35%), Positives = 185/370 (50%), Gaps = 28/370 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPD 60 M RI I GDGIG E++ +RVL A AE + +E +E A + Y G + Sbjct: 1 MTGTRIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAE 60 Query: 61 DWHEQLS-RFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 +L DA G VG PD PD + R D Y N+RPVR +PGVP Sbjct: 61 ADVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSR 120 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFT-RRGVDRILRYAFEL 177 + + +D+ +VRENTEG Y+S G G + + +++ T R G R+ R AF L Sbjct: 121 VRADR---VDYVIVRENTEGLYASRGK----GVGNRWAVTDTLLTTREGTLRVARKAFTL 173 Query: 178 AQSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 A R + +T KSN L S ++ E V +A +PE+ + ++ D V Sbjct: 174 AAGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVELEYRYADAAAQDLV 232 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + PERFDV+V N GD+LSDLG A G +G+ P+ N+ + FEPVHGSAPD+ G Sbjct: 233 LCPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD---GAAYFEPVHGSAPDLVG 289 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN--ATTP 349 +N ANP+ + A AM+LD LG+ DE + A+ V+A G + G Sbjct: 290 RNRANPVGQLLAAAMLLDHLGHVDE-----AARLRRAVSAVLAFGTVRIEADGTVLGGAE 344 Query: 350 QVADAICKII 359 VADA+ + Sbjct: 345 AVADAVIAAL 354 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 310 bits (794), Expect = 6e-83, Method: Composition-based stats. Identities = 108/391 (27%), Positives = 173/391 (44%), Gaps = 48/391 (12%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M + ++ +PGD IG E++ E +++L E F + G + Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQI-SYGLIGGASLDKTGSAIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPG--- 114 D+ E DA+ G+VG P+ VP +S +L R+ D + N+RP R + Sbjct: 60 DEVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLL 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL + +DF +VREN G Y + R V+R R + Sbjct: 120 NQSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARVS 167 Query: 175 FELAQSRPRKT---------LTSATKSNGLAISMPYWDERVEAMAE-NYPEIRWDKQHID 224 LA++ R + +A K+N LA S +W + E +P+I Q D Sbjct: 168 AALARTFGRGKNTDDKSPAIVWNADKANVLA-SGRFWRTVTHDIFEREFPDIELHDQLAD 226 Query: 225 ILCARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLF 279 + V P +F+ V+ N FGDILSD+ G++G+ PSA++ E+ ++ Sbjct: 227 SMAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIY 286 Query: 280 EPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA----- 334 E VHGSAPDI G ANPIA I + AM+L + + + + A+ + + Sbjct: 287 EAVHGSAPDISGTGQANPIAQILSLAMLLRY----SFSMPRQADLLEDAVRKTLEVREHG 342 Query: 335 -HGPKTPDMKGNATTPQVADAIC---KIILR 361 G +T D+ G+A+T V DA+ + +LR Sbjct: 343 GLGIRTKDLGGSASTQDVGDAVAFQFRTLLR 373 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 309 bits (793), Expect = 7e-83, Method: Composition-based stats. Identities = 111/404 (27%), Positives = 172/404 (42%), Gaps = 64/404 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + I GDGIGK+V P +VL+AAA G +S+ ++ +A + + +PDD + Sbjct: 35 VPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRV-FAGESAREKYDENLPDDTVNAI 93 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 G + T P + R+ D Y N+RP GVP P+ P + Sbjct: 94 DEHRVAIKGPL----TTPVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKA--PEE 147 Query: 127 IDFYVVRENTEGEYSSLGGR--------VNEGTEHEVVIQE-----------SVFTRRGV 167 +D RENTE Y+ + V E E ++ + T G Sbjct: 148 MDMVTFRENTEDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGS 207 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE----------- 215 R++R A + A R +T K N + + + E +A E YP+ Sbjct: 208 KRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVFAAPDSLW 267 Query: 216 ------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 + + + D + ++ + F V+ NL GD LSD A G +GI Sbjct: 268 ETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSDAAGAQIGGLGI 327 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP AN R L EPVHGSAP G+N+ANP A I +G +M D++G ++ A + Sbjct: 328 APGANFGDARV---LAEPVHGSAPKRAGQNMANPTAMILSGRLMFDYMG-----WKDAAD 379 Query: 324 GILAAIEEVIAHGPKTPDMKGN------ATTPQVADAICKIILR 361 + A+EE I+ G T D++ T + +DAI + I + Sbjct: 380 LVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 103/357 (28%), Positives = 162/357 (45%), Gaps = 30/357 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG GIG E + + + G + FE ++ DD + Sbjct: 59 VTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDPTMDND-------DDVQYAI 107 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + G G +T + + + R E D Y + + +PGV + D Sbjct: 108 TTIKRNGVGLKGNIETKSEAAYVTSRNVALRNELDMYAYILNCKSYPGVAT-----RHKD 162 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID ++R+NTEGEY+ L G VV V T +R+ R+AFE A+ RK + Sbjct: 163 IDVVIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAKKNGRKKV 218 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T+ K+N + +S + E +A+ YP+I D ID C + V +P +FDV++ +NL+ Sbjct: 219 TTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLY 278 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIWAGA 305 G I+S++ G G+ N ++FEP + I GKNIANPIA I A Sbjct: 279 GSIVSNVVCGLLGGAGLLSGRNYGDHY---AVFEPGTRNTGTAIAGKNIANPIAMINASI 335 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIILR 361 ML+ LG+ Q + + AI + I TPD+ G+ T+ V AI + + R Sbjct: 336 DMLEHLGH-----QFHASLLRRAINKTINVDRVLTPDLGGSNTSTDVVGAILQNVGR 387 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 308 bits (790), Expect = 2e-82, Method: Composition-based stats. Identities = 111/414 (26%), Positives = 172/414 (41%), Gaps = 72/414 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKMMPDDWHE 64 I I GDGIG ++ RV+ AA E+ + E E A + + G+ +P + + Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + G + T P + + R+E D + LRPVR F GVP P+ +P Sbjct: 81 TIKEYLIAVKGPL----TTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVK--RP 134 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV-------------------IQESVFTRR 165 D+D + RENTE Y+ + + +V+ I ++ Sbjct: 135 QDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKE 194 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE--------------------- 204 G +R++R A + A RK++T K N + + + + Sbjct: 195 GTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYD 254 Query: 205 ------------RVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSD 252 + AE +I DI + + +P DVV NL GD +SD Sbjct: 255 EIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISD 314 Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 A G IGIAP AN+N E T ++FE HG+AP G N NP + I + +ML+ LG Sbjct: 315 ALAAQVGGIGIAPGANINYE-TGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLG 373 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPD----MKG--NATTPQVADAICKIIL 360 +Q+A + I +IE+ IA T D M G +T AD + K + Sbjct: 374 -----WQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK 422 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 104/406 (25%), Positives = 160/406 (39%), Gaps = 65/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH-HGKMMPDDWHE 64 I I GDGIG EV I+V A E+ +G + E E G +PD E Sbjct: 47 IGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLPDQSIE 106 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L + + P + R+ FD Y N+RPV+ FPG+P PL ++P Sbjct: 107 VLRKIRVFLKAPL----ETPVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPL--RRP 160 Query: 125 GDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFTRRGVD 168 +D + RENTE Y+ + + I ++ G Sbjct: 161 ELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPISKFGTQ 220 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NYPE------------ 215 RI R A + A R+ +T K N + + E +A + E Sbjct: 221 RIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFEDELAQYG 280 Query: 216 -------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN 268 + + + D + + + + +DV++A NL GD +SD G +G+AP + Sbjct: 281 GSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLGVAPGLD 340 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + + + EPVHG+AP GKN NP ATI A +M FLG +++ I+ Sbjct: 341 VGD---WGMMAEPVHGTAPKYRGKNYVNPTATILALELMFRFLG-----WREVAEYIMKG 392 Query: 329 IEEVIAHGPKTPDMKGNAT-------------TPQVADAICKIILR 361 +E G T D+ T T + AD + +II R Sbjct: 393 VETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIKR 438 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 103/394 (26%), Positives = 168/394 (42%), Gaps = 55/394 (13%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK------- 56 ++ +PGD G +++ + VL + + + + + C + K Sbjct: 14 RYKVCYMPGDDSGFDMMEGALVVLLSM----DLPIDWVRADLGWCMWEKSVNKFGQGDPR 69 Query: 57 --MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 +P + +++ DA A+ V ++L+ R+ FD Y+NLRP + P Sbjct: 70 CNTVPPETIDKIRSSDATLMAAITSKSGV---KGFKSAILQMRQLFDLYINLRPAKTLPD 126 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLG-------------GRVNEGTEHEVVIQESV 161 + PL G ID + RENTE YS++ G +V + V Sbjct: 127 LGSPLKGD--PKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDVAVSWRV 184 Query: 162 FTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE--IRWD 219 F+ G +RI+R AFE A+S R + K+N + + +A+ Y + I Sbjct: 185 FSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQYGITGI 244 Query: 220 KQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLF 279 +++ D + P+ + V+V SN+FGDILSD TG +G APS N+ ++F Sbjct: 245 EENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGEN---TAIF 301 Query: 280 EPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH---G 336 EP GS P + NP A + MML++LG QA I AI EV+ Sbjct: 302 EPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLG-----LDQAGQKIEWAINEVLKENRPK 356 Query: 337 PKTPDM-----------KGNATTPQVADAICKII 359 T D+ + A+T ++A AI + I Sbjct: 357 TLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 306 bits (784), Expect = 8e-82, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 179/374 (47%), Gaps = 24/374 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M T IA + GDGIG EV+ E ++VL+ +R + + + Y++ G PD Sbjct: 1 MTTYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAM-GHAFPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-----VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + + DAI G +G D G+LL RR ++ + N RPV L G+ Sbjct: 60 ETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGL 119 Query: 116 P--CPLAGK-QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL ID ++RE G Y V + + + +I++ Sbjct: 120 AHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVK 179 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 FE++ R +K + + KSN L S W+E VE ++NYPE+ +D + Sbjct: 180 VGFEVSMKR-KKVMHNIHKSNVLKSS-VLWNEIVEEESKNYPEVEVKNILVDAAATYLCL 237 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P FDV+V N+FGDILSD G G++G+ PSA P++++ +EP HGSAPDI GK Sbjct: 238 NPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSY---YEPSHGSAPDIAGK 294 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGNA---T 347 IANP + I + A+ML+ ++ + AA++ V +G T D+ +G A + Sbjct: 295 GIANPYSMIGSVALMLE----MSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVS 350 Query: 348 TPQVADAICKIILR 361 T + D +C + + Sbjct: 351 TAEFGDLVCAELAK 364 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 306 bits (784), Expect = 9e-82, Method: Composition-based stats. Identities = 110/360 (30%), Positives = 168/360 (46%), Gaps = 12/360 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA I GDGIG +V I VL+ A + G A Y+ G + D E Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DAI+ GA+G P + + L+ R F Y +RPV+ +P P LA + Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120 Query: 125 GDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR-- 181 ID ++RE+TEG YS+ + + + V TR+ ++ R+AF LA+ R Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRE 180 Query: 182 --PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 LT K+N S+ ++ + + + + ++ ++D V +P FDV Sbjct: 181 RGHPGRLTCVDKANVF-TSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+A + LF+P HGSAPDI G++ ANP+A Sbjct: 240 LVMENMFGDILSDLAGGLVGGMGMAACGEIGDT---TGLFQPAHGSAPDIMGEDKANPLA 296 Query: 300 TIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAIC 356 I + A+MLD+L A I +A+E H P + G+ T V + Sbjct: 297 AILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKELL 356 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 304 bits (778), Expect = 5e-81, Method: Composition-based stats. Identities = 112/364 (30%), Positives = 178/364 (48%), Gaps = 38/364 (10%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK---- 56 M K + A + GDGIG EV+ +RVL+ + L A E + +G+ Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCE-----AGSEQWDKNGRKDAS 53 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 +PD + L D + G +P + + R++FD Y N+RP + + + Sbjct: 54 YIPDVTMKILEETDCCFKGPTTT---IPVPGAPRSVAVTLRQKFDLYANIRPTKTYDRL- 109 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 +D RE TEG Y+ + ++ + + I TR+G R++ A + Sbjct: 110 -----TPDRKLDCVCFREATEGLYTGVEAKITD----DAAIAIRKITRQGSRRLIDSAVD 160 Query: 177 LAQSRPRKTLTSATKSNGLAISMP-YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 A K + + TK N L + +WDE +A+ +I + +ID + + V+ E Sbjct: 161 WANKFNMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQMVIATE 218 Query: 236 RFD--VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 +F+ V+V++NLF DI+S+L A G+IG+ SAN+ ++FE HGSAP G+N Sbjct: 219 QFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDNY---AMFEAAHGSAPQFAGQN 275 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 NP AT+ +GA M D+LG D R + I AA E+VI G T D+ G+A+T Q+ Sbjct: 276 KVNPTATVLSGAWMADYLGERDVR-----DAIFAATEQVINEGKAVTWDIGGDASTTQMT 330 Query: 353 DAIC 356 DAI Sbjct: 331 DAII 334 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 303 bits (777), Expect = 6e-81, Method: Composition-based stats. Identities = 116/369 (31%), Positives = 177/369 (47%), Gaps = 31/369 (8%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + EG++VL A +E G + E + Y P D ++ D I GAVGW Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 80 PDTVPDHISL---------WGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ-----PG 125 PD + + ++ R + Y N+RP++L+PGV + G G Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK- 184 +D ++RENTEG Y+ GG++ G + +V I V TRR ++++R+AFEL + R + Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 185 ------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +T+ K N L + + + YPEI D +D V QPE +D Sbjct: 181 PKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYD 239 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V V SN+FGDI++DL G +G+A N+ ++FEP+HGSAP GK+ NPI Sbjct: 240 VCVTSNMFGDIVTDLASTLQGGMGMAVGGNIG---KHNAMFEPIHGSAPKHAGKDKVNPI 296 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVA 352 A I + L++L D +A I AA+ EV+ G T D+ GN + +V Sbjct: 297 AMILSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVG 356 Query: 353 DAICKIILR 361 AI + +R Sbjct: 357 SAIAEAAVR 365 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 176/355 (49%), Gaps = 30/355 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG+EV+P + VLQA E SF + + A + G +P+ +E Sbjct: 7 HEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTEKQ-AGDDTRDQTGAALPETTYE 62 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA FGA G +L R +VN+RP R +PGV Sbjct: 63 AAADADATLFGAAGETAA--------DVILPLREAVGSFVNIRPARAYPGV-----DALQ 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + D +RENTEG YS R++E ++ V T +++ YA R Sbjct: 110 PETDLVFLRENTEGVYSGHEDRLSE----DLSTLTRVITTSASEQLAEYACSYVTERSID 165 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 + K+N + + + + V +A + ++ ++ +D R + P +FDVVV N Sbjct: 166 GFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLNPTQFDVVVCPN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GD+LSDL G +G+ PSAN+ +LFEPVHG+APDI G IANP A+I + Sbjct: 225 LAGDVLSDLAAGLVGGLGLLPSANIG---QTNALFEPVHGTAPDIAGDGIANPSASILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L++LG D A + A+E V+ GP+TPD+ GNA+T V +A+ + + Sbjct: 282 GMLLEYLGETD-----AATNVQMAVESVLNSGPRTPDLGGNASTEAVVNAVIEQL 331 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 107/382 (28%), Positives = 160/382 (41%), Gaps = 43/382 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+ + I GDG G E++ VL AA GF L ++ A G+++P Sbjct: 1 MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRP-AGQGALRSVGELLPAS 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + R G T P + + RRE D Y +RPVR++PG AG Sbjct: 60 TLDSIRRNGVALKGPT----TTPIGVGHRSVNITIRRELDLYACVRPVRVWPG-----AG 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEG--------------TEHEVVIQESVFTRRGV 167 ID VVRENTE YS L + + + T G Sbjct: 111 AVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPITPGGS 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAI--SMPYWDERVEAMAENYPEIRWDKQHIDI 225 RI+ +A + A+ R+ + ++ + + E + YP+I + + Sbjct: 171 RRIVAFALDHARKNGRRKVEVG--ADVYRYPRTEGLFFEAARELGPEYPDIVTATVPVTV 228 Query: 226 LCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGS 285 LC V P DV+V NL+GD++SD+ A G +G+AP AN+ ++FE HGS Sbjct: 229 LCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR---TAVFEATHGS 285 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM-- 342 AP+ G N NP A I +G M+LD LG I AA+ V+ G T D+ Sbjct: 286 APEFAGSNRLNPTALILSGCMLLDHLGEAPT-----AARIRAAVRSVLEEGRSVTFDLLP 340 Query: 343 ----KGNATTPQVADAICKIIL 360 TT A+A+ + + Sbjct: 341 PDRAARAVTTTAYAEAVIERLR 362 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 103/417 (24%), Positives = 156/417 (37%), Gaps = 70/417 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ V AA ++ G A Y G+ +P Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D L + G + T P I + R++ D Y RPV +PG P P+ Sbjct: 76 DKTLATLREYLVGIKGPL----TTPIGIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 P +++ V RENTE Y+ + V+ E Sbjct: 132 V--HPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE----- 215 +++G R++ A + A + R TLT K N + + + + AE Y + Sbjct: 190 PISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDKVFTW 249 Query: 216 ---------------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGD 248 + + D + ++ PE F+VV NL GD Sbjct: 250 NQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATMNLNGD 309 Query: 249 ILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML 308 +SD A G IGIAP N+N +T ++FE HG+AP G+N NP + I +GAMM Sbjct: 310 YISDALAAQVGGIGIAPGGNINY-QTGHAIFEATHGTAPQFAGQNKLNPTSIILSGAMMF 368 Query: 309 DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAICKIIL 360 D+LG + N I I+ I T D +T + + ++I Sbjct: 369 DYLG-----WDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIE 420 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 117/342 (34%), Positives = 166/342 (48%), Gaps = 25/342 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + RI AIPG+GIG EV+ +++LQ A+ GF L + W + G P Sbjct: 7 ASYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVD-YGWLGATAFEQLGSYFPQAT 65 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLA 120 E D I FGAV G LL+ R+ FD + NLRP+R + L Sbjct: 66 TELCDGADGIVFGAVS-----------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLR 114 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ +D +VRE G Y GR ++ + + + RI R A E AQ Sbjct: 115 PEKIQGLDILIVRELVSGIYFGPSGRSSDERGNY-GYHTMRYYDEEIRRIARKALEQAQY 173 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R LT A K N L +W V+ A +P + + +D L + V+ P+RFDV+ Sbjct: 174 R-RGLLTVAHKENALPH--LHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 +ASNLFGDILSD+G A G+IG+ SA+LN L+E +HG+APDI G IANP+ T Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNAN--GFGLYEAIHGTAPDIAGLGIANPLGT 288 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 + A +ML G Q + ++A G +T D+ Sbjct: 289 LGACVLMLQQWGEVQAAQQIIAAQ-----DRILAKGYRTADL 325 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 101/401 (25%), Positives = 159/401 (39%), Gaps = 62/401 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG E+ + ++ A E+ G + A + G+ +P + + Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLD 100 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L G +G P + RR FD Y +RPV G P+ P Sbjct: 101 VLKESIVGIKGPLGT----PVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPN--P 153 Query: 125 GDIDFYVVRENTEGEYSSLG-------------------GRVNEGTEHEVVIQESVFTRR 165 +D V RENT+ Y+ + G EG +V I + Sbjct: 154 ERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEF 213 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN------------- 212 R +R A A +K + K N + + + +AE Sbjct: 214 KTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEA 273 Query: 213 ---YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL 269 +++ K D + + V++PE +DV++A NL GD +SDL + G G PS N+ Sbjct: 274 EPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNI 333 Query: 270 NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAI 329 +LFE HG+A DI GK IANP++ +GAMML+++G +++A + A+ Sbjct: 334 GDGY---ALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIG-----WKEAAQKVYDAV 385 Query: 330 EEVIAHGPKTPDMKG----------NATTPQVADAICKIIL 360 +A TPD+ T + A+ I K I Sbjct: 386 RRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 297 bits (761), Expect = 4e-79, Method: Composition-based stats. Identities = 97/403 (24%), Positives = 167/403 (41%), Gaps = 65/403 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW---GFALSFEQMEWA--SCEYYSHHGKMMPDD 61 I I GDGIG ++ P I+V+ AA E+ +++ ++ + + Y +P + Sbjct: 31 IPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQD-TWLPQE 89 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + + G + T P + + R++ D YV RPVR F GVP P+ Sbjct: 90 TLDAVRDYVVSIKGPL----TTPVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPSPVK- 144 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV-------------------IQESVF 162 +PGD+D + REN+E Y+ + + +V+ I Sbjct: 145 -KPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIGIKPV 203 Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN---------- 212 ++ G R++R A + A R ++T K N + + + + +A + Sbjct: 204 SQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAELLDGG 263 Query: 213 ----------YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + D + + +++P +DV+ NL GD LSD A G IG Sbjct: 264 PWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEVGGIG 323 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAH 322 IAP ANL+ ++FE HG+AP G++ NP + I + MML +G + +A Sbjct: 324 IAPGANLSDS---VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRHMG-----WTEAA 375 Query: 323 NGILAAIEEVIAHGPKTPD----MKGNA--TTPQVADAICKII 359 + I+ IA T D M G + + DA+ + Sbjct: 376 DLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 96/405 (23%), Positives = 158/405 (39%), Gaps = 69/405 (17%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC----------------- 48 ++ +PGDGIG E+ + A + ++ + Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYA----NIPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 49 -EYYSHHGKMMPD-----------------------DWHEQLSRFDAIYFGAVGWPDTVP 84 E G+ P D H+ + + G D Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGPFITRDVSK 154 Query: 85 DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLG 144 + ++ Y ++ PV+ +P P D+D VVRENTE EYS L Sbjct: 155 SIDRMLAL------KYGLYAHVVPVKAPQNLP-PSVFTPFRDVDMVVVRENTEAEYSGLE 207 Query: 145 GRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE 204 +V G VV + TR G RI ++AFE A+ R + + K+N + S + E Sbjct: 208 HQVQPG----VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIE 263 Query: 205 RVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVVASNLFGDILSDLGPACTGTIG 262 + +A+ YP+I++ + +D + V P FD VVV NL+G I+S+ + G +G Sbjct: 264 CCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVG 323 Query: 263 IAPSAN---LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQ 319 + N +N + A DI G+ IANPI I + MLD +G Sbjct: 324 VISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMG-----MN 378 Query: 320 QAHNGILAAIEEVIAH---GPKTPDMKGNATTPQVADAICKIILR 361 N I A++E + + TPD+ G ++ +A+ + I + Sbjct: 379 THANRIKFALKETLLNANPKILTPDIGGTGSSVSFIEAMMRHIPK 423 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 292 bits (749), Expect = 9e-78, Method: Composition-based stats. Identities = 99/400 (24%), Positives = 162/400 (40%), Gaps = 61/400 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKMMPDDWHE 64 +A GDGIG E++ +VL AA ++ +G E A E G ++PD + Sbjct: 35 VAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLPDGTLQ 94 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 G + T P + R D Y N+RPV+ + G P P P Sbjct: 95 AFKLARVNLKGPL----TTPVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTPH--CHP 147 Query: 125 GDIDFYVVRENTEGEYSSLGG--------RVNEGTEHEVVIQE--------SVFTRRGVD 168 +ID+ + RENTE Y+ + ++ + + E I+ ++ Sbjct: 148 ENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPISKWRTQ 207 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV---------------EAMAENY 213 R +R A E A K +T K N + + + + E + Y Sbjct: 208 RHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEEVNTKY 267 Query: 214 PE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSA 267 I + + D + + + +P ++V+V NL GD +SD A G IG+A Sbjct: 268 GGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIGMAAGL 327 Query: 268 NLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGIL 326 ++ ++ EPVHGSAP GKN+ NP A I +G +L DF+G + + + Sbjct: 328 DMGD---GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKL-----LVE 379 Query: 327 AAIEEVIAHGPKTPDM----KG--NATTPQVADAICKIIL 360 A+++ IAH T D+ G +T + D + I Sbjct: 380 YAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 292 bits (748), Expect = 1e-77, Method: Composition-based stats. Identities = 94/409 (22%), Positives = 168/409 (41%), Gaps = 71/409 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW---GFALSFEQMEWASC--EYYSHHGKMMPD- 60 I I GDGIG ++ P I+V+ +A ++ +++ ++ + + H ++ P+ Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 61 -----DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D E ++ + G + T P + R++ D YV LRPVR + G Sbjct: 92 QWLLPDTIEAINHYKVSIKGPL----TTPIGEGFRSLNVALRQKMDLYVCLRPVRWY-GS 146 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV------------------- 156 P P+ P +D + REN+E Y+ + + +++ Sbjct: 147 PSPVKE--PQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSG 204 Query: 157 IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN---- 212 + ++ G +R++R A E A + ++T K N + + + + A+A+ Sbjct: 205 VGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNA 264 Query: 213 ----------------YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 EI D + +++P + V+ NL GD +SD A Sbjct: 265 QVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAA 324 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G IGIAP ANLN +FE HG+AP G + NP + I + MML +G Sbjct: 325 MVGGIGIAPGANLNDT---VGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMG---- 377 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPD----MKGNA--TTPQVADAICKII 359 + +A + I++A+E+ I T D M G + A + + + Sbjct: 378 -WVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 292 bits (748), Expect = 1e-77, Method: Composition-based stats. Identities = 98/402 (24%), Positives = 158/402 (39%), Gaps = 64/402 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSH---HGKMMPDDW 62 I I GDGIG +V P ++V+ AA A+ +G E +E + E + +P++ Sbjct: 29 IPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEET 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 L + G + T P + + R+ D YV RPV+ F GVP P+ Sbjct: 89 LNILQEYKVSIKGPL----TTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV-------------------IQESVFT 163 +P ++D + RENTE Y+ + + V+ I + Sbjct: 143 RPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVS 202 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN----------- 212 + G R++R A + A + ++T K N + + + + +A Sbjct: 203 KEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLLHGGP 262 Query: 213 ---------YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 EI D + + +++P + V+ NL GD LSD A G IGI Sbjct: 263 WCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQVGGIGI 322 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP ANL E ++FE HG+AP GKN NP + I + MML +G + + Sbjct: 323 APGANLGDE---VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWLE------AD 373 Query: 324 GILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKII 359 +L + I T D + + D I + Sbjct: 374 LLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 77/359 (21%), Positives = 161/359 (44%), Gaps = 37/359 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 KT ++ I G+G+G+E++ V+ A + ++ + E+ + + + Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEV 136 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L G V + R++F Q+ + G+ P Sbjct: 137 LKSLRANKVGIKGPVDSRHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY--- 183 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 GD D ++R+ EG+YS + V G V+ V T G RI + F A Sbjct: 184 --GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNK 237 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T A K+N + ++ + E + A A+ + ++ ++++++D + +++P + DV+V Sbjct: 238 RKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMV 297 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +S+++GD+L + G GI P +++ + ++F+ + + GK++ANP + Sbjct: 298 SSSMYGDVLRVIAGGMMGVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANPTGPL 354 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + A+ML + + + + + AI +V +TPD+ G A + A+C + Sbjct: 355 LSAALMLRHV-----KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 290 bits (742), Expect = 7e-77, Method: Composition-based stats. Identities = 94/358 (26%), Positives = 165/358 (46%), Gaps = 26/358 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + G GIG E++ +RVL+AA G LS+E +S + ++ D+ Sbjct: 37 KTNVTILTGSGIGPEIMDHTLRVLKAA----GAPLSYEIFALSSKDGSKNNDF---DEAL 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P + + FR+ D +V + + FPG+ + Sbjct: 90 TSIRRNRVALKGNIELQSKNP---HIKSRNIIFRKTLDLFVYILFCKTFPGLS-----NK 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G+ID V+R+NTEGEY L G+ V V TR ++R++ +AF+ A + R Sbjct: 142 FGEIDITVIRQNTEGEYLMLEHEPRTGS----VESLKVLTRFNLERLIEFAFDYALTNDR 197 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T +N ++ + ++++YP I+ + +++ + P FDV++A+ Sbjct: 198 KLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVILAT 257 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL G ++S+ G G+ N + + ++FEP I G N ANPIA I Sbjct: 258 NLNGSMISNYLNGMLGGPGLTSGINFSAD--GIAVFEPGARNKGSSIVGLNRANPIAMIM 315 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +G +L LG ++ + HN + A + + +TPD+ G AT + D I + I Sbjct: 316 SGINLLHHLGY-NKTAEMIHNSVYATL---VYDKIRTPDIGGQATAEETVDHIIRHIR 369 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 289 bits (739), Expect = 1e-76, Method: Composition-based stats. Identities = 99/399 (24%), Positives = 166/399 (41%), Gaps = 61/399 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFA---LSFEQMEWASCEYYSHHGKMMPDDWH 63 IA I GDG+G++V+P +V+ +A A + + Q+ + G P + Sbjct: 34 IAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDWFPQETI 93 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + T P + R+E D +VN+R ++ F +P PL Sbjct: 94 NAVRECKIAIKGPL----TTPLGGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKN-- 147 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTR 164 P + V+R+++E YS + + +V I ++ Sbjct: 148 PYLTNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISK 207 Query: 165 RGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NYPEI------- 216 G +R++RYA A ++LT K N L + + A+A+ Y I Sbjct: 208 EGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQAIDDENGRW 267 Query: 217 -----------RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 + D + + +M PE+FDVV +N GD L+D+ A G +GI P Sbjct: 268 LHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADMLSAQVGGVGIMP 327 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGI 325 +ANLN E + FEP HG+ I G+N ANP ++I + +ML F+ ++ +A N I Sbjct: 328 AANLNNE---VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKFM-----QWHEAANLI 379 Query: 326 LAAIEEVIAHGPKTPDMKGN------ATTPQVADAICKI 358 A+E +A G T D+ + A + + Sbjct: 380 ENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 289 bits (739), Expect = 2e-76, Method: Composition-based stats. Identities = 82/297 (27%), Positives = 127/297 (42%), Gaps = 23/297 (7%) Query: 39 SFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRR 98 FE++ +S + + R G + +P S R Sbjct: 1 DFEEVHVSSNADEEDIRNAI-----MAIRRNRVALKGNIETNHNLP--PSHKSRNNILRT 53 Query: 99 EFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 D Y N+ + PGV + DID +VRENTEGEYSSL G VV Sbjct: 54 SLDLYANVIHWKSLPGVVT-----RHKDIDILIVRENTEGEYSSLEHESVAG----VVES 104 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T+ RI YAF+LAQ RK +T+ K+N + + + + +A YP+I + Sbjct: 105 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITF 164 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 + +D + V +P++FDV+V NL+G+I++++ G G+ AN + Sbjct: 165 ENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYG--HVYAVF 222 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 + I KNIANP AT+ A MMLD L + I A+ + + Sbjct: 223 ETATRNTGKSIANKNIANPTATLLASCMMLDHL-----KLHSYATSIRKAVLASMDN 274 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 99/363 (27%), Positives = 172/363 (47%), Gaps = 30/363 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF--ALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I GDGIG + + R+L+ + + F+ ++ + E + +P + + Sbjct: 44 IGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAEVLK 103 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L I G P ++ + + R+E D + N+RPVR+ Sbjct: 104 ELKECHVILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE----------- 152 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID+ RENTEG Y+ G ++ + +V T G +RI+R AFE A++ + Sbjct: 153 QGIDWTFYRENTEGAYAV--GSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKT 210 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV--MQPERFDVVVA 242 +T+ TK+N + + + + +A++Y +I D +IDI+ A+ + + + F V+V Sbjct: 211 RVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKDFQVMVL 270 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANPIA 299 NL+GDI++D G +G A SAN+ S+FE +HGSAP + + A+P + Sbjct: 271 PNLYGDIITDEAAEFQGGVGTAGSANIGKRY---SMFEAIHGSAPRMVQEGRDQYADPCS 327 Query: 300 TIWAGAMMLDFLGNGDE--RFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 I AGAM+L +G G E + QA + ++++ G T AT + AD I + Sbjct: 328 VIRAGAMLLAHIGYGKEADKLYQALDICTVTEKKLVITGRNTG-----ATGAEFADYIME 382 Query: 358 IIL 360 I Sbjct: 383 TIE 385 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 286 bits (733), Expect = 7e-76, Method: Composition-based stats. Identities = 98/361 (27%), Positives = 175/361 (48%), Gaps = 31/361 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + + +PGDGIG E++ + I+++++ G+ ++ + ++ Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKSCI-YTGYKINIIYNYIGGIS-IDKFNTPITNNLIS 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + D I+ G VG LLK R++F+ + N+RP++ CP Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK---- 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV----VIQESVFTRRGVDRILRYAFELAQS 180 +ID +VRE G Y ++ +++ ++ + + R+ R +F LA + Sbjct: 110 -NIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLALN 168 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R +K L S KSN L + W + + + + Y +++ +ID + +FDV+ Sbjct: 169 R-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFDVI 226 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 + SNLFGDI+SDL TG++G+ PS ++N + SLFEP HGSAPDI KNIANP+ Sbjct: 227 ITSNLFGDIISDLCSLLTGSLGMLPSISINNK--SLSLFEPCHGSAPDIANKNIANPVGA 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + + MM +++ N + N + +I +V+++G T DMK +T + D Sbjct: 285 LLSLVMMFEYVLNDF----KLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDL 340 Query: 355 I 355 + Sbjct: 341 V 341 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 286 bits (732), Expect = 8e-76, Method: Composition-based stats. Identities = 88/373 (23%), Positives = 150/373 (40%), Gaps = 39/373 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ + GD IG EV+ E + + +G + + H + + Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGS-CLDQHDCPIQES 68 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHIS--LWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 ++ S A+ G+VG P S +L+ R+ + Y N+RP ++ Sbjct: 69 TLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L ++ +REN G Y + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI--RWDKQHIDILCARFVMQP 234 LA S + S K+N +A S + E + + +P++ + Q +D P Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN-------PERTFPSLFEPVHGSA 286 + + VV+ NLFGDILSDL G++G+ SA ++ R +++PV GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 PDI GK IANPI + +M + +A + I +AI++ + G T D+ G Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRW----SLGLPKAADAIDSAIKDCLESGQCTRDVGGTL 345 Query: 347 TTPQVADAICKII 359 +T Q A+ + I Sbjct: 346 STQQAGSALRQSI 358 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 122/402 (30%), Positives = 172/402 (42%), Gaps = 65/402 (16%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 RI +PGDGIG E+ ++ W L+ Q+ W+ + HG +P + Sbjct: 13 APRRITLLPGDGIGPEITDACRGLIADVFPHW--ELTETQIGWSQ---WRAHGNPVPQET 67 Query: 63 HEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 E L R DA A+ P ++ +L+ R+ D + N+RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-T 126 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSS----LGGRVNEGTEH-------------- 153 PG DF +VRENTEG YS + H Sbjct: 127 LPGAAA----------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVA 176 Query: 154 -------EVVIQESVFTRRGVDRILRYAFELAQSRPRK--------TLTSATKSNGLAIS 198 EV + V T R+ R A +LA +R T+T A K N L S Sbjct: 177 RAVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDS 236 Query: 199 MPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 VE +AE YP++ +D + D + + V P RFDV++A NL GDILSD+G Sbjct: 237 ARVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLI 296 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +G+A SAN+ ++FEPVHGSAPDI G+ IANP A + + AM + LG Sbjct: 297 GGLGLAASANVGDN---FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSEL 353 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 A + A+ P T D+ G ATT + A+ + Sbjct: 354 APAAK-LREAVYAATRTAP-TLDLGGTATTSEFVAAVRAELG 393 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 279 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 109/368 (29%), Positives = 179/368 (48%), Gaps = 45/368 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIGKE++P+ ++ + F S E Y + G + D ++L Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTF-----YNISSERYINKGITIKDSEIDEL 58 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +++I+FGA+G P I G +L+ R+E D Y+N+RP F + + Sbjct: 59 KSYNSIFFGAIGDFRVKP-GIMEQGVILRLRKELDLYMNIRPAISFSRI-------TGNN 110 Query: 127 IDFYVVRENTEGEYSSLGGRVNEG-------------------TEHEVVIQESVFTRRGV 167 I ++REN E YS + G +NE ++ + +R+ + Sbjct: 111 IHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNL 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 R A+++A + +T+T K+N + + W E +E + + + ++ D L Sbjct: 171 KRFFNMAYKIADT---ETVTITDKANAVDMYS-LWREIAIEESEPAGK-KINFEYADSLA 225 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P ++ ++A NL+GDILSD+ A G +G APS N+ + S+FEPVHGSAP Sbjct: 226 YNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD---YSSMFEPVHGSAP 282 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 DI GKNIANP+A+I + MML L + + ++E VI +G + GNA Sbjct: 283 DIAGKNIANPVASILSCIMMLKHLNQT-----ETAGIMEKSVENVIRNGTIPIESGGNAG 337 Query: 348 TPQVADAI 355 T + + + Sbjct: 338 THEFINKV 345 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 278 bits (711), Expect = 3e-73, Method: Composition-based stats. Identities = 89/366 (24%), Positives = 158/366 (43%), Gaps = 30/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAA--AERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + +PGDGIG ++ + +RV + E + F + + E + +P + Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E D + G P ++ + RR Y +RPVR+ Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE--------- 157 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ REN EGEY + G + ++ + V TR G +RI R AFE A++ Sbjct: 158 --KGIDWTFFRENIEGEY--IWGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNG 213 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ--PERFDVV 240 + +T TK+N + + + + A+ + YP I ++ +D + A+ Q + V Sbjct: 214 KTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 + NL+GDI++D+ G +G A S+N+ + +LFE +HG + N A+P Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQY---ALFEAIHGVGNFLVQHNRAQYADP 330 Query: 298 IATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 + I A M+ +G + E+ +A + +V+ T D G AT + D + Sbjct: 331 CSLIRAMGEMISHIGYPEKKEQLVKALDICTRTERKVVI----TTDKDG-ATAEEFTDYL 385 Query: 356 CKIILR 361 + R Sbjct: 386 LDTLQR 391 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 276 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 119/376 (31%), Positives = 178/376 (47%), Gaps = 29/376 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MK IA IP DG+GK+V+P G + +Q A E G F L E A EY GKM D Sbjct: 1 MKKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE-AGVEYAVKTGKMCED 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT------VPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + E +++ DA+ G+ G D P + + L R + LRP+RL G Sbjct: 60 NLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + CPL + +ID +VR+ EG Y G + E + V TR ++ Sbjct: 120 IDCPLRNR--EEIDVLLVRQLAEGFYIRPGHMIGE----DAAYDTIVVTRNVTEKFADTC 173 Query: 175 FELAQSR------PRKTLTSATK-SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 F LA+ R +K +T K N ++ + ++ YP+I +D L Sbjct: 174 FRLARGRHGRRQDGKKMVTLGNKHGNV--TCFDFYRKIFTEVSAGYPDIGLQFTQVDALA 231 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P+RFDV+ N+ GDI+ D+G TG +GI P+A++ F P HG+ P Sbjct: 232 EHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVG---GVTPQFRPNHGTFP 288 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIE-EVIAHGPKTPDMKG 344 GK ANP+A+I ++LD LGN GD+ ++ I A+E + GP+T D+ G Sbjct: 289 RAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGG 348 Query: 345 NATTPQVADAICKIIL 360 A T A+A+ K + Sbjct: 349 TANTFATAEAVFKAME 364 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 72/258 (27%), Positives = 113/258 (43%), Gaps = 31/258 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ I GDG G E+ RVL+A G A ++ ++ A + G +PD E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA----TGVAFDWD-IQDAGVDVMEQLGTPLPDSVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + T P + R+E D Y +RP R +PGV Sbjct: 58 SIRSTKVALKAPI----TTPVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRSRF----- 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-----------------VIQESVFTRRGV 167 +ID VVRENTE Y+ + E+ I + G Sbjct: 109 ENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGS 168 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 +RI+R+AFE A++ RK +T+ K+N + S + E +A+ YP+I +D + +D +C Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMC 228 Query: 228 ARFVMQPERFDVVVASNL 245 + V +PE +DV+V NL Sbjct: 229 MQLVQKPELYDVMVLPNL 246 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 269 bits (688), Expect = 1e-70, Method: Composition-based stats. Identities = 111/372 (29%), Positives = 161/372 (43%), Gaps = 72/372 (19%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 ++T+RI IPGDGIGKEV+P G R+L+A G F + A E + G +PD Sbjct: 3 IRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLH-AGFETFERTGAALPDK 61 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L D FGAV P + S ++ R++ D Y N+RPV+ P Sbjct: 62 TVEILRNECDGALFGAVSSPSSPVKGYS--SPIVALRKKLDLYANVRPVKTVLSAAKP-- 117 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ID +VRENTE Y + + +V + R RI A ++A Sbjct: 118 ------IDMVIVRENTEDLYV-KEETTRDTPDGKVAEAIKRISERASHRIATMAGDIALR 170 Query: 181 RPRKT------------LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 R + +T KSN L + Sbjct: 171 RQKIRAAGAPSIHQSPLVTITHKSNVL-----LRLK------------------------ 201 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 +V+V NL+GDILSD A G++G+ PSAN+ ++ EP HGSAPD Sbjct: 202 ---------NVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE---GFAIGEPCHGSAPD 249 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNAT 347 I G+NIANPIAT+ + A+ML+FL + ++ + G +PD+ G A Sbjct: 250 IMGQNIANPIATLRSAALMLEFLDEEAAAAKIYAA-----VDANLTEGKLLSPDLGGTAK 304 Query: 348 TPQVADAICKII 359 T +V + I + + Sbjct: 305 TTEVIEDILRRL 316 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 95/457 (20%), Positives = 159/457 (34%), Gaps = 119/457 (26%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQME-WASCEYYSHHGKM--MPDDW 62 + I GDG G ++ P +VL AA A+ + + +A E +G +P D Sbjct: 29 VPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQYLPQDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + T P + + R+ FD Y +RP R + G P P Sbjct: 89 LTAIKEYGIAIKGPL----TTPIGGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKS- 143 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + + I Sbjct: 144 -PDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIPLDAGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA------ 210 +R G R++R A + A P++ +T K N + + + + +A Sbjct: 203 IKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELATQEFRA 262 Query: 211 --------------ENYPEIRWDK--QHID------------------------------ 224 E P+I ++ + ID Sbjct: 263 ECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTPEKKAQIVKEVETVINSIWSTHG 322 Query: 225 ----------------ILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN 268 + + +P+ + ++ NL GD LSD A G +G+ P AN Sbjct: 323 DGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGAN 382 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + ++FE HG+AP G + NP + I +G MML+++G +Q+A + I Sbjct: 383 IGDS---CAIFEATHGTAPKHAGLDKINPGSVILSGVMMLEYMG-----WQEAADLIKRG 434 Query: 329 IEEVIAHGPKTPDMKG-------NATTPQVADAICKI 358 + IA G T D+ + AD I + Sbjct: 435 LGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 268 bits (685), Expect = 3e-70, Method: Composition-based stats. Identities = 93/371 (25%), Positives = 166/371 (44%), Gaps = 34/371 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFA--LSFEQMEWASCEYYSHHGKMMP 59 + +++ +PGDGIG ++ + V + ++ + F ++ + E + K +P Sbjct: 35 LSHVKVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLP 94 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 E D + G P +L + RR+ Y +RP+R+ Sbjct: 95 PAVLEACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE------ 148 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 ID+ REN EGEY + G ++ I + ++ G +R+ R AFE A+ Sbjct: 149 -----KGIDWTFFRENIEGEY--IWGNKGICVGDDLAIDFKILSKPGAERLFRNAFEYAK 201 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE---R 236 S + +T ATK+N + + + + AM + YP I ++ ID L A+ M PE Sbjct: 202 SSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKL-MDPEFNAG 260 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI-- 294 V V NL+GDIL+D+ G +G A S+N+ + ++FE +HG + N Sbjct: 261 MQVFVLPNLYGDILTDIAAEYQGGLGTASSSNIGDQY---AMFEAIHGVGVYLVEHNRAQ 317 Query: 295 -ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE---EVIAHGPKTPDMKGNATTPQ 350 A+P + I A M+ F+G ++R + + A++ +V T D G AT + Sbjct: 318 YADPSSLIRAMGEMMAFIGYPEKR-----DRLFKALDFCTKVERKAVITTDKDG-ATAEE 371 Query: 351 VADAICKIILR 361 A+ + + + + Sbjct: 372 FAEYVVETLHK 382 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 266 bits (680), Expect = 8e-70, Method: Composition-based stats. Identities = 96/367 (26%), Positives = 154/367 (41%), Gaps = 17/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + IA IPGDG+G E+ E + L+ A E +G + F + A +P + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTE-AIAGTAALDRGQCPLPRE 69 Query: 62 WHEQLSRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 + D+I G AVG + L R ++RP + C Sbjct: 70 SLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 118 PLAGK-QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + + +D ++R+ G +++ G N + + R AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFTTEGKSSNLCNVR-AAWDTESYDETLIRDSARLAFQ 188 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA SR RK +TS K+ L S W + +E +YPEI + +D + V P+ Sbjct: 189 LAASRKRK-VTSLDKA-ILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDA 246 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+VASN+FGDI++D TG P+ +LN ER +H ++ G AN Sbjct: 247 FDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRAN 306 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPD--MKG--NATTPQVA 352 P+ I A AMML++ + G+ A+ V+ G G A T + Sbjct: 307 PVGMILAAAMMLEY----SFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIG 362 Query: 353 DAICKII 359 +A+ + + Sbjct: 363 EAVRECL 369 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 266 bits (680), Expect = 9e-70, Method: Composition-based stats. Identities = 125/337 (37%), Positives = 169/337 (50%), Gaps = 52/337 (15%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IAAI GDGIG EV+ G + A ++ W + S Sbjct: 16 YKIAAIRGDGIGPEVIEAG---------NYQSAEETNRVAWILLNWPSRT---------- 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLR------PVRLFPGVPCP 118 GAV D + S + F Y+ LR P R+F G+ P Sbjct: 57 --------LSGAVRITRNTADISPISSSTFLW---FSSYLPLRSSTSNMPTRVFHGIQSP 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D+ +VREN+EGEY+ GGR G EV S+FTR GV+RI+++AFE A Sbjct: 106 L------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAA 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVE-AMAENYPEIRWDKQHIDILCARFVMQPERF 237 +SR +K +T ATKSN + WDE +A +P++ DK +D + AR V+ PE Sbjct: 160 RSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPESL 219 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +NL ILSDL A G+IGIAP++NL+P R PS+FEPVHGSA DI GK++A Sbjct: 220 DTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA-- 277 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 T W A ML +LG A +L +E V Sbjct: 278 --TFWTVAEMLSWLGQKG-----AAAELLECVESVCK 307 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 263 bits (673), Expect = 6e-69, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 148/342 (43%), Gaps = 37/342 (10%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + V+ A + ++ + E+ + + + + L G V Sbjct: 1 MDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS 52 Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 + R++F Q+ + G+ P GD D ++R+ EG+ Sbjct: 53 RHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGD 97 Query: 140 YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 YS + V G V+ V T G RI + F A RK +T A K+N + ++ Sbjct: 98 YSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTD 153 Query: 200 PYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + E + A A+ + ++ ++++++D + +++P + DV+V+S+++GD+L + Sbjct: 154 GNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMM 213 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G GI P +++ + ++F+ + + GK++ANP + + A+ML + + Sbjct: 214 GVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHV-----KM 265 Query: 319 QQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + + + AI +V +TPD+ G A + A+C + Sbjct: 266 DKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 262 bits (670), Expect = 1e-68, Method: Composition-based stats. Identities = 79/373 (21%), Positives = 147/373 (39%), Gaps = 40/373 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK---MMP 59 + +R+ I G G G VL ++ +AA + + ++ + Y H + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAAL----VPVEW---DYQTLSVYRDHKTNRMTVN 91 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + + + + SL L + + +V +R G Sbjct: 92 PQLLDSAIETGLVL---CAKDSSPRQNDSLESDSLALHKALNAFVGVRKFNSVVG----- 143 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + G I+ +RE+ GEYS + V+ G VV +++ + + AF+ A Sbjct: 144 -HEPYGPINLVNIREHVSGEYSEIEHLVSPG----VVQSIKTVSKKISVEVAKLAFDYAC 198 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 +T K++ + +S + + ++ YP++ ++++ +D C P R++V Sbjct: 199 KHGHSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRYEV 258 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV------HGSAPDIYGK- 292 ++ ++L+G + +G + P+ P+ T S H I+ K Sbjct: 259 LLTTSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKM 318 Query: 293 -----NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 I NP I A A+MLD G A I AA+E+ I G +T DM G+A+ Sbjct: 319 VYGQEQIINPTGIIRAAALMLDHAG-----MVVAGRCIAAAVEDTIRQGIRTQDMGGDAS 373 Query: 348 TPQVADAICKIIL 360 Q DAI K + Sbjct: 374 CSQFTDAIIKNLK 386 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 262 bits (670), Expect = 2e-68, Method: Composition-based stats. Identities = 92/361 (25%), Positives = 154/361 (42%), Gaps = 29/361 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ + G G+G++ R+ AA + FE + A H +P + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFE-VHLAGRMALEHGKDALPKATFDA 57 Query: 66 LSRFDAIYF------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + VG P + FRR+ + ++RPV PG+P Sbjct: 58 IRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSRF 117 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 +DF + RE TE Y++ + G VV + T R + AF+ A+ Sbjct: 118 T-----GVDFLLFREITEDLYTASEHEIVPG----VVQSFKIVTEAACLRFFKLAFDTAR 168 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RKT+ K+N L ++ + E +A+ YPEI +D C + V +P++F+V Sbjct: 169 KRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEV 228 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + A NL+GD+LSDLG G + + N +++E V+G++ + +++NP+ Sbjct: 229 LAAGNLYGDLLSDLGAGLVGGVSTTAAINKG---NGTTVYEAVYGASHEAVPPDMSNPLP 285 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I +L LG I A+E V+ G +T D+ G ATT DAI Sbjct: 286 LILPAIELLKDLGETGT-----AGRIQKAVETVLLEGRIRTRDIGGTATTTAFTDAIVSR 340 Query: 359 I 359 + Sbjct: 341 M 341 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 260 bits (666), Expect = 4e-68, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 150/359 (41%), Gaps = 21/359 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG+G+G EV+ + +L+ E G + G+ + + Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV---- 85 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAGKQP 124 F A F G P + RR FD Y L P+R +P + L + Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAA 142 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VREN G Y G EG Q + V+RILR A LA R R Sbjct: 143 RSADVLIVRENASGLYCGEWGSEGEGAARS-AYQVCRYRADEVERILRTALRLAGQR-RG 200 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L TK G+ W + + A+A + +R +D + + P +FDV+V N Sbjct: 201 DLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPN 260 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDIL D G G+ G++ S N ++++ HG+A D+ G++ ANPI + + Sbjct: 261 MFGDILGDCGSLLMGSRGMSWSGNYGA--AGQAVYQTAHGAAWDLAGRDRANPIGQVCSL 318 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAICKII 359 AMML R + + AI +A G +T D++G T + A+C + Sbjct: 319 AMMLR----ESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQALCASL 373 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 259 bits (663), Expect = 1e-67, Method: Composition-based stats. Identities = 103/367 (28%), Positives = 143/367 (38%), Gaps = 43/367 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E ++VL+A F Q H + Sbjct: 1 MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTA 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-ISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 DAI GA+G P+ P + LL+ R+E Y NLRP Sbjct: 61 KALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL DF VVRE T G Y E + ++R ++RI R A Sbjct: 121 SPLKADVCRGTDFIVVRELTGGIYFGA---RTEDDGSGFAMDTDAYSRAEIERIARLAGF 177 Query: 177 LAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA + P + S K+N LA S + E A +P++ Q ID V P Sbjct: 178 LALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 + VVV SNLFGDI+SD G+I G I Sbjct: 238 ALNGVVVTSNLFGDIISDEASVIPGSI-----------------------------GAGI 268 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NPI TI + AMML + N + + A++ +G +T D+ G+A T Q+ADA Sbjct: 269 VNPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTALD----NGTRTKDLGGSAGTFQMADA 324 Query: 355 ICKIILR 361 + +++ Sbjct: 325 VVVELVK 331 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 257 bits (657), Expect = 4e-67, Method: Composition-based stats. Identities = 96/360 (26%), Positives = 147/360 (40%), Gaps = 30/360 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M I + GDGI +E+ V A F + F ++ S E G + D+ Sbjct: 6 MNRYSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDL-SDESREAKGDAIYDE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + R+ G P + R + V RPV PG+ Sbjct: 61 AEAAMRRY--------GTSLKYPTATTKESPNRVLRERCNFAVIHRPVATIPGIQTHYNE 112 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + I +VR T G Y G R+N T + RR R+AF LAQ R Sbjct: 113 R----IHLDIVRIATGGTYEDAGRRINRDT----AVSIRAIERRPSVLASRFAFRLAQLR 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + + +K + + E +A +YP + ++ D L A +M+PER+ V+V Sbjct: 165 D-SNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTF---PSLFEPVHGSAPDIYGKNIANPI 298 N +GD LSD+ G+IG+ SA+ + + ++F+P G+APDI G+N ANP Sbjct: 224 CPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPT 283 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A + A A ML +G D + A+ I G KT D+ G+ + I Sbjct: 284 AALLAMANMLRHIGEHDS-----SKALRGALFGAIEAGEKTADIGGSLNLSEFTQVIVDR 338 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 252 bits (644), Expect = 1e-65, Method: Composition-based stats. Identities = 111/346 (32%), Positives = 172/346 (49%), Gaps = 47/346 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A IPGDGIG+E++P AAA ++F + S E Y G ++ DD E+L Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDI-SSERYIKTGIIIKDDELEEL 57 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + AI FGA+G P P I G +L+ RRE + Y+N+RPVR F Sbjct: 58 KNYRAILFGAIGDPRVRP-GIMEQGVILRLRRELELYMNIRPVRSFDD-----------K 105 Query: 127 IDFYVVRENTEGEYSSLGG---------------RVNEGTEHEVVIQESVFTRRGVDRIL 171 I ++RENT+ Y+ + G ++ + EV + + R + + Sbjct: 106 IKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFF 165 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 AF + S T+T K+N + + W A I ++ D L + Sbjct: 166 NKAFSICDS----TVTVTDKANAVKMY-NLWRSTAMEAAIE-KNINISFEYADALAYNMI 219 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + P+++ ++A NL+GDI+SD+G A G +G APSAN+ + +LFEPVHGSAPDI G Sbjct: 220 LNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDKN---ALFEPVHGSAPDIAG 276 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 +++ANP A+I AG+M+L++LG DE I + + +G Sbjct: 277 RDMANPAASIMAGSMLLEYLGYRDE-----SRIINDMVRNLYINGV 317 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 241 bits (616), Expect = 3e-62, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 142/326 (43%), Gaps = 35/326 (10%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + ++V + ++ + S G+ + E L R G Sbjct: 2 IESLVKVFSTVQ----VPIDWDVFH--EHKINSAEGEDVSPKLLESLCRNKIGIKGPFES 55 Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 L K R++F + + R G + G +D ++R+ EGE Sbjct: 56 GPC----------LRKLRKKFQLFAFVAVCRNLEG-----QNTRYGKLDCLIIRDQVEGE 100 Query: 140 YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 YS + RV G V+ V T G DR+ RY FE A+ RK +T A K+N + ++ Sbjct: 101 YSGIEHRVVPG----VMQTIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLTD 156 Query: 200 PYWDERVEAMAENYP-EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + + A Y +I ++++++D +C +M+PER DV+VAS+++GD+L+ + + Sbjct: 157 GTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASIM 216 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G + P + P ++EP+ + +I GK+I NP + +G +ML + + Sbjct: 217 GGPALCPGFAVGP---MGLIYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLREM-----KL 268 Query: 319 QQAHNGILAAIEEVIAHGP-KTPDMK 343 + + I A+ V +T D+ Sbjct: 269 NEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 237 bits (605), Expect = 5e-61, Method: Composition-based stats. Identities = 75/355 (21%), Positives = 130/355 (36%), Gaps = 23/355 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + ++A +PGDG G + R L R + + ++ + G +P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---PCP 118 + DA+ G P I LL R+E + VN+RPVR Sbjct: 68 TLGACRQSDAVLVCGCGDPRY---GIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + +D R+ T G Y + E + ++R+ ++RI R A A Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGE---AYDTTPYSRQTIERIARLAGTYA 181 Query: 179 QS-RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 P K + S K N +A S + +P++ +D P Sbjct: 182 MQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDPLSL 241 Query: 238 D-VVVASNLFGDILSDLGPACTGTIGIAPSANL-----NPERTFPSLFEPVHGSAPDIYG 291 + +++ N+FGDILSD G+ + SA + R P +FEP + + G Sbjct: 242 NGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNP----G 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE--EVIAHGPKTPDMKG 344 P+ +I A +ML+ + I ++ E++ +T D+ G Sbjct: 298 GKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 98/365 (26%), Positives = 148/365 (40%), Gaps = 33/365 (9%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPDDWH 63 +R+A +PGDG+G+EVL R+L+ AER ++ W + G ++P Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTG---PWPVGARAAAETGDVLPAGTL 58 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHI--SLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 DAI GAVG VP + +L + R +D +++R + G Sbjct: 59 AACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGRE----- 113 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 VVR G Y RV E TR V ++ A ++ R Sbjct: 114 -------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLGRR 165 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 L S K+N L + W + +A I + +++D DV+V Sbjct: 166 GGGRLVSVDKAN-LYATGRLWRQVAGDVARE-RGIEVEHRYVDRAAFELGSGAPVPDVLV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP----SLFEPVHGSAPDIYGKNIANP 297 L GDILSDL G+ + SA+L+P LFEP HGSAP ++ +P Sbjct: 224 TEGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDP 283 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVAD 353 + A A +L ++A + AA+ V+ GP T D+ A+T QVAD Sbjct: 284 LGGFLALAALLRHF----PATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVAD 339 Query: 354 AICKI 358 A+ Sbjct: 340 AVLAA 344 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 234 bits (596), Expect = 6e-60, Method: Composition-based stats. Identities = 93/362 (25%), Positives = 148/362 (40%), Gaps = 17/362 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 T I + GD G+E+L + +RVLQ + R L F + S E + + Sbjct: 4 TTPTIVVMHGDQTGEELLIQALRVLQPSVIRQ--PLQFLDYDL-SLENRRATDNKVVWEA 60 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A P+ D S R + V LR R P + P+AG Sbjct: 61 AQAARDSGLSLKAATITPEIAGDVGSPNAI---LREALNAKVILRTGRRIPKI-RPIAGV 116 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +VR + Y S R E+ + S +R + + F+ A R Sbjct: 117 YS---PIAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFTFQYA-KRT 172 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 + + K A + E ++A A+ YPE+ + ID A + V+ A Sbjct: 173 KAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTGESLVIPA 232 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPI 298 N GD+LSD+ G+I + S L ++ + E HG+AP ++GKNIANP+ Sbjct: 233 LNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPM 292 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A I AGA +L + + ++A I ++ E I G TPD+ G TT + D + + Sbjct: 293 AMILAGAALLSY--GRIPQAEKASRAIYESVFETIYEGKATPDLGGQMTTSEFTDEVIRR 350 Query: 359 IL 360 + Sbjct: 351 VE 352 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 231 bits (590), Expect = 3e-59, Method: Composition-based stats. Identities = 102/365 (27%), Positives = 154/365 (42%), Gaps = 17/365 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++I + GD G+E+L + +RVL E G L E+ + S E + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDL-SLENRRATQNGVVS 57 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D + A P+ D S R E D V +R R PGV P+A Sbjct: 58 DAAAAMRTCGFGIKAATITPEGADDVGSPNRI---LREEVDGKVIVRTGRRIPGV-TPIA 113 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +VR E Y + R + G EV + TR + YAF A+ Sbjct: 114 GVHY---PISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEYAFRTAR 170 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP-ERFD 238 + + K + E ++A A +P++ ++ ID A V + Sbjct: 171 AMQ-ARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGAADEPL 229 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNIA 295 VV A N GD LSDL G+I A S L + T ++ E HG+AP + GK++A Sbjct: 230 VVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVA 289 Query: 296 NPIATIWAGAMMLDFLGN-GDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NP+A + A +L G ++A I ++ E IA G KTPD+ G+A T + DA Sbjct: 290 NPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTDA 349 Query: 355 ICKII 359 + + I Sbjct: 350 VIERI 354 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 229 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 78/342 (22%), Positives = 152/342 (44%), Gaps = 45/342 (13%) Query: 18 EVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAV 77 E+ + LQ A G ++++ ++ + ++P+ + + G + Sbjct: 12 ELGAQVTNALQMAIAATGVDITWQIVDIGGED----QQGLLPNYIFDIIRTAKTAVIGPL 67 Query: 78 GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE 137 +PD+ + R + D YVNLRP + G+P ++D +VRE TE Sbjct: 68 ----MMPDNYRQMEA--DIREKLDLYVNLRPAKTMVGIPSNYQ-----NVDIMIVRETTE 116 Query: 138 GEYSSLGGR----------------VNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G Y+ + + + + + +G +I+ +AF A+ Sbjct: 117 GIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKT 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R + + +++ +A + + E +A+ +P+I + + I+++C + +PERFDV+V Sbjct: 177 KRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GD+L+ L G + + P A++ + ++F + D G + P + I Sbjct: 237 MPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKY---AVFGA-QSTGTDDVGHD---PTSLI 288 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDM 342 AGA+ML LG Q+A + AA+E V+A H T D+ Sbjct: 289 LAGALMLRHLGE-----QEAAQRLQAAVEAVVASHVDTTADL 325 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 224 bits (570), Expect = 6e-57, Method: Composition-based stats. Identities = 109/343 (31%), Positives = 162/343 (47%), Gaps = 21/343 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T R+ G+GIG E++ ++ ++ A + G A E + G+++P++ Sbjct: 5 ETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEET 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E ++ D G P R++ D + N+RPVR PG P Sbjct: 65 WETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP---- 120 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEG---TEHEVVIQESVFTRRGVDRILRYAFELAQ 179 D+D +VRENTEG Y+ + G EV + VFT+ + RI+R A Sbjct: 121 ---DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVRRA-AAIA 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + LT A KSN L + + +A AE + + HID LCA V +PER+ Sbjct: 177 AARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTRPERYAT 235 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +VA N+FGDILSDL G++GIA S N + + + + HGSAPDI G+ IANP Sbjct: 236 IVAENMFGDILSDLAGGLGGSLGIAGSINASESQV---MAQAAHGSAPDIAGQGIANPAG 292 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 + + A MLD LG QA + A+ E + P T D+ Sbjct: 293 IMNSAAQMLDSLGY-----PQAAELLEGAVREAVVKAP-TADL 329 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 219 bits (557), Expect = 2e-55, Method: Composition-based stats. Identities = 91/255 (35%), Positives = 126/255 (49%), Gaps = 19/255 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG E++ + VL+AAA R L F + A + + G M E++ Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSED-AGADAFRRTGSAMSAATLERI 66 Query: 67 S-RFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 R+ + G VG P PD R D Y N+RP+ L PGV PL G Sbjct: 67 RTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTA- 125 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESV-FTRRGVDRILRYAFELAQSR-- 181 +D+ +VRENTEG Y S G G ++ + + TR GV+R++ +AFELA R Sbjct: 126 --VDYVIVRENTEGLYLSRG----RGVGNDRACADQLLMTRHGVERVVVHAFELATRRTG 179 Query: 182 ----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + +T KSN L S ++ E + +A YP++ D ++ D V P RF Sbjct: 180 APADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRF 238 Query: 238 DVVVASNLFGDILSD 252 DV+V N GDILSD Sbjct: 239 DVLVMENFLGDILSD 253 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 197 bits (500), Expect = 7e-49, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 89/165 (53%), Gaps = 9/165 (5%) Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 +S + V MA+ +PEI+++++++D +C V P ++DV+V NL+GDILSD+ Sbjct: 112 RMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 171 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 G +G+ PS N+ +LFE VHG+APDI GK++ANP A + + MML + Sbjct: 172 GLVGGLGLTPSGNMG---LNGALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM---- 224 Query: 316 ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + I A E I G T D+ G A + + IC + Sbjct: 225 -ELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 268 Score = 52.6 bits (125), Expect = 2e-05, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 21/42 (50%), Gaps = 4/42 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW 45 T ++ IPGDGIG E+ ++ AA + +E ++ Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDV 84 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 187 bits (474), Expect = 8e-46, Method: Composition-based stats. Identities = 68/376 (18%), Positives = 137/376 (36%), Gaps = 46/376 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAE---RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + I I GDGIG E+ I V+ +A E + ++ + ++ E Y G +P+D Sbjct: 24 LTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILI-GTEAYEKFGTYVPED 82 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 +++ + +Y + +PD R+ Y N+R ++ G+ P+ Sbjct: 83 SIKEIQK---MYIAMKSTLNFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMDIPVN- 135 Query: 122 KQPGDIDFYVVR-------------ENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVD 168 ++ ++R E+T+ + + I ++ Sbjct: 136 -TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFRTR 194 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 +I + A ++ +K +T + + A ++ ++ Sbjct: 195 KIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEASAQEDVGYEVLKTREFMK 249 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 R + PE F+V++ N+ L D GTI I +++ E ++FE V S P Sbjct: 250 RLISSPEDFEVILVDNVLSQTLVDY---LAGTINIEYGSSIGDE---CAVFEAVQSSLPS 303 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN--- 345 G + A+P++ I +G ML +G + +A I AI D+ Sbjct: 304 EAGYDAADPLSFILSGCEMLMHIG-----WVEAAQIIENAISAAFRDNKIPKDINTRPDI 358 Query: 346 --ATTPQVADAICKII 359 + + I K + Sbjct: 359 SPIKCSEFSSEIIKRM 374 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 177 bits (450), Expect = 4e-43, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 106/268 (39%), Gaps = 19/268 (7%) Query: 94 LKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH 153 LK + D YV + +R FPG C D+D V+ +N G YS L +G Sbjct: 135 LKICNDLDLYVFMTRLRSFPGFKCRFP-----DVDIQVIAQNNIGNYSELEYAPVKG--- 186 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 VV V T V + LR+AFE A R +T K+N ++ E E M AE+ Sbjct: 187 -VVEALRVVTHENVTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAED 245 Query: 213 YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 Y I+ + +D R + P FD + ++ + L+ + G + + L Sbjct: 246 YCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIELGDS 305 Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV 332 ++F+P+ + + ++ +P + +L+ +G + + + Sbjct: 306 H---AVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQ-----ESCAKSLWKGMLRT 356 Query: 333 IAHGPKTPDMKGNATTPQVADAICKIIL 360 + G KT + G T V I + Sbjct: 357 MTDGIKTVEFDGPDTGEYVICNIMNKLR 384 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 170 bits (432), Expect = 5e-41, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 121/342 (35%), Gaps = 61/342 (17%) Query: 19 VLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVG 78 V +V+ A + FE + + + + + + G V Sbjct: 12 VTNAVHQVMDAMQA----PVYFETYIIKG-----KNMNHLTWEVVDSIRKNKVCLNGRVN 62 Query: 79 WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEG 138 R+E D + +L G P + ++D V+RENTEG Sbjct: 63 NSLCGGA-----------RKELDLFASLVDCFNLNGQPS-----RHENVDIVVIRENTEG 106 Query: 139 EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL-AI 197 EY+ V G + T+ DRI +YAFE A RK +T+ + + Sbjct: 107 EYAGREHEVVPGVIESFQVT---MTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNGKYEKL 163 Query: 198 SMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + ++ E + +A+ YP I +++ +R R S I++++ Sbjct: 164 ADAFFLESCQEVAKMYPNITYNEI-----ASRETRAIRRHS---NSKSLWAIIANIASGV 215 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDER 317 G + + ++FE V N NP+A +++ MML L Sbjct: 216 AGG-------SFGDDY---AIFEQVGSVG------NHKNPVALLFSSVMMLRHL-----L 254 Query: 318 FQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + A+ VI+ G N TT +V D++ + Sbjct: 255 LPLFADRLKTAVTRVISEGKC---GNSNTTTQEVVDSVIANL 293 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 167 bits (422), Expect = 8e-40, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 108/286 (37%), Gaps = 26/286 (9%) Query: 81 DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEY 140 D P LLK R+E Y ++RP L Q + + + Sbjct: 35 DGAPATSRPERGLLKLRKEMGTYGSMRPCFFASD---SLVAPQGRGVPRHRLCHCARAHR 91 Query: 141 SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 L R G+ ++ V+R A L + R K L S +N LA S Sbjct: 92 RYLLWRAQTGSGS--AWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSRF 149 Query: 201 YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVASNLFGDILSDLGPACTG 259 + E + +P+++ + Q I+ V P + VVV S LFGDI+SD Sbjct: 150 WRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPD 209 Query: 260 TIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 +IG+ PSA+L + R ++EP+H + + A+ + + Sbjct: 210 SIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC----------- 256 Query: 316 ERFQQAHNGILAAIEE--VIAHGPKTPDMKGNATTPQVADAICKII 359 + + + ++ V +T ++ G A T ++ +A+ + Sbjct: 257 -PWPCFSDTLSTSLRRLWVPPWSLRTKELGGGANTKELGEAVINEV 301 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 164 bits (416), Expect = 4e-39, Method: Composition-based stats. Identities = 78/371 (21%), Positives = 140/371 (37%), Gaps = 42/371 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY----YSHHGKM 57 M ++++ G+G G E+ RV+Q+ A R+ +++F + Y + Sbjct: 1 MSSIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADA 60 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 + ++ + + AV S+ L RE Q + + L P Sbjct: 61 VTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQAIKVEHFTLSPTSS- 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 +VR+ +G YS + T + V + + F++ RIL YA Sbjct: 120 -----------ILLVRDQAQGFYSG---TNSVNTSKDAVSRTAHFSKAIFARILSYALGR 165 Query: 178 AQSR--PRKTLTSATKSNGLAISMPYWD----ERVEAMAENYPEIRWDKQHIDILCARFV 231 A ++T K + + E N ++ D + D+L Sbjct: 166 ANQLWGGTNSVTMVYKFHLF---DGLFHTWATEWERTFGVNIRFVQGDTMNRDLLAFGV- 221 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSA-----NLNPERTFPSLFEPVHGSA 286 +++++ N + DI+ + G +G SA L+P+ S ++ HGSA Sbjct: 222 ---SGHNLLISGNEYADIMQTILLDRFG-LGAQESACAENVYLHPDVQGLSEYQTAHGSA 277 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 D+ GK I NP ATI A A +L+ + + ++ A G TPD G A Sbjct: 278 DDLLGKGIVNPTATIRAAAAVLEDQAGCSG----LKQRVDCVLGDLGARGIGTPDQGGTA 333 Query: 347 TTPQVADAICK 357 TT + +A + Sbjct: 334 TTERFVEAFLQ 344 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 160 bits (405), Expect = 7e-38, Method: Composition-based stats. Identities = 48/131 (36%), Positives = 67/131 (51%), Gaps = 8/131 (6%) Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P +FDV+V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGAN--GVAIFESVHGTAPDI 87 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATT 348 GK++ANP A + + MML +G I A + I T D+ GN Sbjct: 88 AGKDMANPTALLLSAVMMLRHMG-----LHGHAKKIETACFDTIRDKKVLTKDLGGNPKC 142 Query: 349 PQVADAICKII 359 + IC+ + Sbjct: 143 SEFTADICRRV 153 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 160 bits (404), Expect = 9e-38, Method: Composition-based stats. Identities = 51/234 (21%), Positives = 83/234 (35%), Gaps = 36/234 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQME-WASCEYYSHHGKM--MPDDW 62 I I GDG G ++ P V+ AA A+ +G + +A E +G P+D Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + T P + + R+ FD Y +RP R +PG P P Sbjct: 89 LTAIKEYGVAIKGPL----TTPVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + I Sbjct: 143 TPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRLDSGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA 210 ++ G R++R A A+ P+ +T K N + + + + +A Sbjct: 203 IKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELA 256 Score = 133 bits (334), Expect = 1e-29, Method: Composition-based stats. Identities = 42/151 (27%), Positives = 69/151 (45%), Gaps = 16/151 (10%) Query: 216 IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTF 275 + + + D + + +P+ + ++ NL GD LSD A G +G+ P AN+ Sbjct: 330 VMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGANIGDS--- 386 Query: 276 PSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 ++FE HG+AP G + NP + I +G MML+F+G +Q+A + I I IA+ Sbjct: 387 AAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMG-----WQEAADLIKKGIGAAIAN 441 Query: 336 GPKTPDMKG--------NATTPQVADAICKI 358 T D+ + A AI Sbjct: 442 REVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 156 bits (394), Expect = 2e-36, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 115/302 (38%), Gaps = 22/302 (7%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E ++++ +K + D Y+ VR FPG C Sbjct: 93 DPLETDDFYNSVLRNRSAVHVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGFNCRFP 152 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D++ ++ +N G YS L +G VV SV T+ G ++ LR AF A Sbjct: 153 -----DVNIRIIAQNNMGVYSDLEYSPVKG----VVEAISVSTQEGNEKYLRKAFATAVK 203 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDV 239 RK +T KS I+ + + ++Y + + +++ R + P+ FD Sbjct: 204 ANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHCLELELMNVEDCIGRLITHPQEFDC 263 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + +S+ + +++ + G + + + F ++F+P+ + I +P Sbjct: 264 IFSSDRYATMIATMCSGICGGANLFSAVEIGD---FHAVFKPLQ-VKLSLTNYPILSPYG 319 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + D LG + + + + + G KT D G + V IC II Sbjct: 320 IVNTIVDLFDHLGYT-----ECGDALWEQMLRTMESGIKTKDFGGEDSGEYV---ICNII 371 Query: 360 LR 361 R Sbjct: 372 NR 373 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 155 bits (391), Expect = 3e-36, Method: Composition-based stats. Identities = 80/385 (20%), Positives = 145/385 (37%), Gaps = 57/385 (14%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 ++T+R+ G G G+E++ RV+Q A+++ F + +S Y+S+H + + Sbjct: 3 IQTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVR---SSSTYHSYHTLTVSGE 59 Query: 62 WHEQLSRF------DAIYF-----GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 ++ DAI + A G ++ L R+ Q + Sbjct: 60 DKNLITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYLVRQHLQAAKVEHFS 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRI 170 L G +VR+ +G Y+ + + + + F++ DRI Sbjct: 120 LGDGNA------------LLMVRDEAQGFYAG---DNTYSADQLSITRTTSFSKPVFDRI 164 Query: 171 LRYAFELAQSR-----PRKTLTSATKSNGLAISMPYWDERVEAMAENYP---EIRWDKQH 222 +R+A + A K +T +A +D +A + I +D Sbjct: 165 IRFALDRAAENWGPENVPKKVT-------MAYKFHLFDGVFQAWEPQWKAQFGIDFDFIQ 217 Query: 223 IDILCARFVMQ-PERFDVVVASNLFGDI-----LSDLGPACTGTIGIAPSANLNPERTFP 276 D L + + +++A N + D+ L+ G + T+ A + L P+ Sbjct: 218 PDTLNRSLMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETM-YAENVYLRPDVNGL 276 Query: 277 SLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAH 335 S ++ VHGSA I K + NP ATI A A +L G AI+ ++ Sbjct: 277 SEYQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKG-----IQKLTEQAIQSLLQR 331 Query: 336 GPKTPDMKGNATTPQVADAICKIIL 360 TPD G+ T + D + I Sbjct: 332 KLTTPDQGGSLKTEETVDHFLQAIA 356 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 145 bits (367), Expect = 2e-33, Method: Composition-based stats. Identities = 50/268 (18%), Positives = 105/268 (39%), Gaps = 20/268 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++A + GD V+ + +++++ A ++ + + +P+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDS-TAFEVTELPF-GVNGVLSFNEPLPNQTLR 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLAGK 122 +L +D I GA+ +S+ SL+ R+ + + + V++ PL + Sbjct: 60 ELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLKNQ 119 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTE-----HEVVIQESVFTRRGVDRILRYAFEL 177 D DF +V+ R N+ + + + +R V++++ FE Sbjct: 120 IVRDTDFIIVQ---------SAKRANDHVDGNISVDDFAQDTITYEQREVEQVITAGFER 170 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A +R R +T T + S W E +A+ YP++ + + + + + QP Sbjct: 171 AMNRKR-AVTVVTPFDSFYTS-KIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSL 228 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAP 265 DVVVA +L++ TG P Sbjct: 229 DVVVAPKWVDQVLNEESQKITGLPETVP 256 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 140 bits (353), Expect = 9e-32, Method: Composition-based stats. Identities = 47/168 (27%), Positives = 73/168 (43%), Gaps = 16/168 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG E+ +++ AA + FE E A + Y G+++P+ +E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFET-ENAGSDVYEKTGELIPESLYES 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R G + T P + R+++D Y N R R PG+ Sbjct: 58 VERNKIAIKGPI----TTPIGKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY-----D 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 +ID + RENTEG Y NE E I T++G + +L+ Sbjct: 109 NIDLAIFRENTEGIYIGEEKYENE--EKTSAIAVKRITKKGSEELLKV 154 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 137 bits (346), Expect = 5e-31, Method: Composition-based stats. Identities = 49/197 (24%), Positives = 83/197 (42%), Gaps = 29/197 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH---HGKMMPDDW 62 I I GDGIG ++ P I+V+ AA ++ +G ME + E + +P + Sbjct: 31 IPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQET 90 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + G + T P + + R++ D YV LRPVR F GVP P+ Sbjct: 91 LDAVKDYVVSIKGPL----TTPVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVK-- 144 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVVIQESVFT 163 +PGD+D + REN+E Y+ + + + + I + Sbjct: 145 KPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGVKPVS 204 Query: 164 RRGVDRILRYAFELAQS 180 + G R+ R A A++ Sbjct: 205 KEGTKRLARKALHSAEA 221 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 128 bits (323), Expect = 2e-28, Method: Composition-based stats. Identities = 72/387 (18%), Positives = 134/387 (34%), Gaps = 64/387 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M +RI G G G E+ V++ A R+ + F + + Y+S++ + D+ Sbjct: 4 MDPLRIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRI---YHSYNSLPLADE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + + G + FR + V L Sbjct: 61 SQNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAIS-------AQSLYAVRQQLEA 113 Query: 122 KQPGDID-----FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 + D V+R+ +G Y+ ++ + V + F + I+ ++ E Sbjct: 114 VKVECFDRGTSSLLVIRDQAQGFYTG---TNKLESDQDSVSRVCHFRKGVFQHIIAFSLE 170 Query: 177 LAQSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ + K++ K + + + I+ + D + Sbjct: 171 RAREKWGYDLGGIKSVFLVYKFHLF---DGLLLSWARDWTKEF-GIKVEFIQPDTMNRNL 226 Query: 231 VMQPERFDV----VVASNLFGDILSDL----------GPACTGTIGIAPSANLNPERTFP 276 + F V ++A N + DI+ + +C+ + + P N Sbjct: 227 I----AFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNR------L 276 Query: 277 SLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI--- 333 S ++ HGSA DI GK I NP ATI A A +L+ G GI A +++ + Sbjct: 277 SEYQTTHGSADDITGKGIVNPSATIRAAAAILERFGGCV--------GIDAKVDDTLNIL 328 Query: 334 -AHGPKTPDMKGNATTPQVADAICKII 359 + TPD GN TT D + + Sbjct: 329 QKNKSGTPDQGGNLTTAAFVDVFLRTL 355 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 128 bits (323), Expect = 3e-28, Method: Composition-based stats. Identities = 41/160 (25%), Positives = 57/160 (35%), Gaps = 18/160 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + PG G+G E+ + AA + +++ + ++ D Sbjct: 31 QFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHID-VDNAKPGQDLISADAL 85 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P L R+ Y N+RP PGV P Sbjct: 86 DSLRRNRFGLKGPMAT----PIGKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---- 137 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFT 163 D+D VRENTEGEYS L V G VV V T Sbjct: 138 -DDVDVVTVRENTEGEYSGLEHVVYPG----VVESLKVIT 172 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 123 bits (310), Expect = 7e-27, Method: Composition-based stats. Identities = 66/125 (52%), Positives = 80/125 (64%), Gaps = 12/125 (9%) Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT- 300 N+FGDILSDLGPACTGTI +APS ++NPE FPSLFEPVHGS PDI+GK IANPI Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 301 --IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG----PKTPDMKGNATTPQVADA 354 GAM+LD LG + I + IE+V++ G P TPD+ G+A T + A Sbjct: 61 ARFGVGAMILDHLGY-----PETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKA 115 Query: 355 ICKII 359 I I Sbjct: 116 IAAAI 120 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 116 bits (292), Expect = 1e-24, Method: Composition-based stats. Identities = 34/114 (29%), Positives = 50/114 (43%), Gaps = 3/114 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 98 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + DA+ GA+G D+ H+ LL+ R + NLRP + P Sbjct: 99 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 111 bits (277), Expect = 5e-23, Method: Composition-based stats. Identities = 46/226 (20%), Positives = 89/226 (39%), Gaps = 18/226 (7%) Query: 138 GEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 G ++ L EG VV SV +++G D+ LRYAF+ A RK +T K+ I Sbjct: 2 GIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPI 57 Query: 198 SMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 S E + + +Y + + + ++ +R + +P FD + AS + LS + Sbjct: 58 SDGSLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSG 117 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN--PIATIWAGAMMLDFLGNG 314 G + + + ++F+P+ + N AN + + LG+ Sbjct: 118 VCGGANLFSAVEIGDHH---AVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGH- 170 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + + ++ + G +T + G T V I + Sbjct: 171 ----DKCADALWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLR 212 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 102 bits (254), Expect = 2e-20, Method: Composition-based stats. Identities = 31/111 (27%), Positives = 46/111 (41%), Gaps = 9/111 (8%) Query: 96 FRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV 155 D Y ++ ++ P V D+D VV ENTEGEYS+L +G V Sbjct: 2 LHTTLDLYASVIHLKNLPNVET-----WHKDVDILVVWENTEGEYSNLEHESVKG----V 52 Query: 156 VIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 + T+ RI YAF+LAQ K + + K N + + + Sbjct: 53 TESLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 96.1 bits (238), Expect = 2e-18, Method: Composition-based stats. Identities = 42/132 (31%), Positives = 64/132 (48%), Gaps = 12/132 (9%) Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + P R + A NL GDI SD+ A G++ A S + ++ LFE HG+A D Sbjct: 430 KMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASS--IIESKSSTMLFEAPHGTAHD 487 Query: 289 IYGKNIA--------NPIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPK 338 +Y K + NP A I+A A L+ LG +E + AA+++ + G Sbjct: 488 LYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYSARLKAALKDTVGDGIV 547 Query: 339 TPDMKGNATTPQ 350 T D+K TTP+ Sbjct: 548 TADLKDKTTTPE 559 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 95.7 bits (237), Expect = 2e-18, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 7/113 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I I GDGIG E++ E +VL ++G + +E + C G + D+ Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCS-IDATGVPLTDEAIAA 62 Query: 66 LSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLF 112 DA+ G++G + LLK R+ + + NLRP L+ Sbjct: 63 AKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 95.4 bits (236), Expect = 3e-18, Method: Composition-based stats. Identities = 30/135 (22%), Positives = 55/135 (40%), Gaps = 7/135 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQ-AAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + ++ + GD IG E++ E ++ L ER F + A + + Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAGAS-LDKTNEPIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-- 115 D + DA+ G+VG P+ +P ++ +L+ R+ D + N+RP R Sbjct: 60 DKVLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRFCASSLV 119 Query: 116 -PCPLAGKQPGDIDF 129 PL ++F Sbjct: 120 EQSPLKSDMVNGVNF 134 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 93.4 bits (231), Expect = 1e-17, Method: Composition-based stats. Identities = 68/379 (17%), Positives = 135/379 (35%), Gaps = 61/379 (16%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERW---GFALSFEQMEWASCEYYSHHGKMMPDD 61 + I I GDG G E+ I + +A E ++ ++++ + E Y +GK +P + Sbjct: 16 VTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKI-YIGREAYEKYGKYLPRE 74 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP----- 116 E + + + G + +I+ + +R + Y +++ + PG+ Sbjct: 75 SIEDIRKTVFVMKGPLSS------NINGHDININIKRILNLYTDVKCITGLPGLSEGKEI 128 Query: 117 ---CPLAGKQ------PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGV 167 P + D D R+ Y ++ G + ++ +R Sbjct: 129 FIFSPSIDEVYHFSYDSEDSDML--RQ-----YLQQSFNISIGGDSDIF--LKGTSRY-- 177 Query: 168 DRILRYAFELAQ---SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHID 224 RI++ A ++A+ K A G P W + + + + + Sbjct: 178 -RIIKIASKIAEISSLYGIKRTLVADDYTGSHA--PLW--VYNTLNKMEMPVEIENLY-- 230 Query: 225 ILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHG 284 L + RF++ + + ++ + A T A L F SLFE Sbjct: 231 NLYDEMTSE-SRFNIFIPDSRLSSLIIKIINART-----FFGAILGD---FISLFESQSR 281 Query: 285 SAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP--DM 342 + G ++A+P + + A +MML L F A + A+ V + G ++ Sbjct: 282 PSFTEEGYDLADPTSFLLASSMMLRRL-----NFNDAALILRNALNSVYSDGILPASLNL 336 Query: 343 KGNATTPQVADAICKIILR 361 DAI K + R Sbjct: 337 NNGLKCSDFIDAIVKRMKR 355 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 92.7 bits (229), Expect = 2e-17, Method: Composition-based stats. Identities = 73/417 (17%), Positives = 128/417 (30%), Gaps = 69/417 (16%) Query: 3 KTMRIA--AIPGDGIGKEVLPEGIRVL-QAAAERW---GFALSFEQMEWASCEYYSHHGK 56 K +++A + DG E R++ Q E+ + + + + Sbjct: 42 KRIKVAKPVVEMDG------DEMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQ 95 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLW----GSLLKFRREFDQYVNLRPV--- 109 + D A+ + + + L R V P+ Sbjct: 96 VTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICK 155 Query: 110 ---RLFPGVPCPLA------GKQPGDIDFYVVRENT--------EGEYSSLGGRVNEGTE 152 RL PG P+ G Q DF R T +G S + Sbjct: 156 NIPRLVPGWTKPITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDG--SGVKEWEVYNFP 213 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN 212 V T + F+ A + L +TK+ L + + + + + Sbjct: 214 AGGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEIFDK 272 Query: 213 YPE-------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 + + I ++ + ID + A+ + F V N GD+ SD+ G++G+ Sbjct: 273 HYKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMT 331 Query: 266 SANLNPERTFPSLFEPVHGSAPDIY---GKNI---ANPIATIWAGAMMLDFLGNGD--ER 317 S + P+ E HG+ Y K NPIA+I+A L+ G D + Sbjct: 332 SVLVCPDGKTI-EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQD 390 Query: 318 FQQAHNGILAAIEEVIAHGPKTPDMKGN-------------ATTPQVADAICKIILR 361 + + E + G T D+ G T D I + R Sbjct: 391 LIRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDR 447 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 92.3 bits (228), Expect = 2e-17, Method: Composition-based stats. Identities = 44/81 (54%), Positives = 57/81 (70%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + RIA IPGDGIGKE +PE +RV AAA R+GFAL ++AS + + HGK+ PDD Sbjct: 1 MSSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDD 60 Query: 62 WHEQLSRFDAIYFGAVGWPDT 82 + L +DA++FGAVG PDT Sbjct: 61 RFDTLRGYDALFFGAVGRPDT 81 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 90.3 bits (223), Expect = 9e-17, Method: Composition-based stats. Identities = 40/134 (29%), Positives = 64/134 (47%), Gaps = 12/134 (8%) Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 ++ + P R+ + A NL GDI SD+ A G++ A S + + T LFE HG+A Sbjct: 428 LSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTL--LFEAPHGTA 485 Query: 287 PDIYGKNIA--------NPIATIWAGAMMLDFLGNGDERFQ--QAHNGILAAIEEVIAHG 336 D+Y + + N A I+A A L+ L ++ + + AA+ E +A G Sbjct: 486 HDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNAPLAEYAEALKAALIETVAQG 545 Query: 337 PKTPDMKGNATTPQ 350 T D+KG P+ Sbjct: 546 TITGDLKGKTLAPE 559 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 90.0 bits (222), Expect = 1e-16, Method: Composition-based stats. Identities = 69/398 (17%), Positives = 126/398 (31%), Gaps = 65/398 (16%) Query: 21 PEGIRVLQAAAERWGFALSFEQMEWA----SCEYYSHHGKMMPDDWHEQLSRFDAIYFGA 76 E RV+ A + L + + S ++ + D + R A Sbjct: 194 DEMARVI-WAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTIDAALAIKRHGVGVKCA 252 Query: 77 VGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYV 131 PD R D + P+ L VP + + Sbjct: 253 TITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPI-LMKNVPRLVPSWTK---PIII 308 Query: 132 VRENTEGEYSSLGGRVNEGTE---------------HEV------VIQESVF-TRRGVDR 169 R +Y +L V++ HEV + ++ T + Sbjct: 309 GRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKGGGVALGMYNTDASIKG 368 Query: 170 ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AENYPE------IRWDKQH 222 F+ A + L +TK+ L + + + + + Y + + ++ + Sbjct: 369 FAHSCFQYALD-QKMPLYLSTKNTVLKKYDGRFKDIFQTIYEKEYKQKFEEAGLWYEHRL 427 Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV 282 ID + A+ + F V N GD+ SD+ G++G+ S + P+ E Sbjct: 428 IDDMVAQAIKSSGGF-VWACKNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTI-EAEAA 485 Query: 283 HGSAPDI---YGKNI---ANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIA 334 HG+ Y K I NPIA+I+A L D ++ ++ + A E + Sbjct: 486 HGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKLKEFVEALEDACVETVE 545 Query: 335 HGPKTPDM-----KGNAT------TPQVADAICKIILR 361 G T D+ T T D + ++ R Sbjct: 546 AGFMTKDLALAIKGDKLTDRDYLCTEDFMDKLARVAER 583 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 87.6 bits (216), Expect = 5e-16, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 48/134 (35%), Gaps = 15/134 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+L + + + + FE + S + Sbjct: 50 RHTVTLIPGDGIGPELLNHVRELFRFSC----VPVDFEVVHVNSSSTSEDDIS----NAI 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + T+P + +L R D Y N+ + PGV + Sbjct: 102 MAIRRNGVALKGNIETNHTMPPNHKSRNNL--LRTSLDLYANVMHCQSLPGVQT-----R 154 Query: 124 PGDIDFYVVRENTE 137 +ID ++ E +E Sbjct: 155 HKNIDIIIILEKSE 168 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 86.5 bits (213), Expect = 1e-15, Method: Composition-based stats. Identities = 75/375 (20%), Positives = 128/375 (34%), Gaps = 48/375 (12%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY-------YSHHGKMM 58 + G G G+EV RVL A R ++ + Y G + Sbjct: 32 TVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAGV 91 Query: 59 PD---DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKF-RREFDQYVNLRPVRLFPG 114 P+ E + ++ V ++ L R+ R V+ Sbjct: 92 PEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQRL------RAVK---- 141 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + +VR+ +G Y+ G G V + + F+R +++L YA Sbjct: 142 ----VDTLDADGARLLLVRDEAQGFYTG-GNTHTPGH----VSRTTEFSREITEQLLAYA 192 Query: 175 FELAQSR---PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 A+ + A K + L D V A I D + V Sbjct: 193 LRRAREEWPEGPARIVMAYKFHLL---DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLV 248 Query: 232 MQP-ERFDVVVASNLFGDILSDLGPACTGTI----GIAPSANLNPERTFPSLFEPVHGSA 286 P E V++A N + DI+ + G+ + +L+P ++ VHGSA Sbjct: 249 AHPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAVAELVEYQTVHGSA 308 Query: 287 PDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN 345 D+ G+++ NP+AT+ A A + ++G A V +TPD G Sbjct: 309 DDLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGV-----RTPDQGGK 363 Query: 346 ATTPQVADAICKIIL 360 +T V DA + + Sbjct: 364 HSTTGVVDAFIEELG 378 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 84.6 bits (208), Expect = 5e-15, Method: Composition-based stats. Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TP 340 VHGSAP G NP A + +G MML +L +A I +++V+A T Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNE-----HEAATRIEKGVDKVLAEAKHLTY 58 Query: 341 DMKGNATTPQVADAICKIIL 360 D G A+T + ADAI K + Sbjct: 59 DAGGTASTDEYADAIIKAMG 78 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 83.8 bits (206), Expect = 9e-15, Method: Composition-based stats. Identities = 65/402 (16%), Positives = 119/402 (29%), Gaps = 68/402 (16%) Query: 16 GKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYF 74 G+E+ + +++A E ++ + + + +++ D E AI+ Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTAWREFDLRAKNRDDTEDQVLRD-VIEAGKAVKAIFK 76 Query: 75 GAVGWP-----DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDF 129 P + S RR ++ R GV + Sbjct: 77 EPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE--- 133 Query: 130 YVVRENTEGEYSSLGGRVNEGT-------------EHEVVIQESVFTRRG---------- 166 R GEY++ V +GT V + T Sbjct: 134 ---RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNPY 190 Query: 167 --VDRILRYAFELAQSRPRKTLT--SATKSNGLAISMPYWDERVEAMAENYP-------- 214 V + R+ F +T TK P+W + E Y Sbjct: 191 DNVHELARFFFGRCLE---AKITPYVVTKKTVFKWQEPFWQIMKKVFDEEYKSKFVDAGV 247 Query: 215 ---EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 D + V + + A N GD+L+D + G S + Sbjct: 248 MKSGDELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGFITSNLVGV 307 Query: 272 ERTFPSL--FEPVHGSAPD-----IYGKNIA-NPIATIWAGAMMLDFLGNGD----ERFQ 319 + + FE HG+ D + G+ + NP+ + ++ + ER Sbjct: 308 DENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNVDKERTL 367 Query: 320 QAHNGILAAIEEVIAHGPKTPDMKGNA--TTPQVADAICKII 359 + A I ++ G T D+ G + TT Q DA+ + + Sbjct: 368 AFTAKMRAVIHQLFREGKGTRDLSGPSGLTTEQFVDAVAERL 409 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 83.8 bits (206), Expect = 1e-14, Method: Composition-based stats. Identities = 64/370 (17%), Positives = 118/370 (31%), Gaps = 67/370 (18%) Query: 47 SCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLW---------GSLLKFR 97 EY + + E + ++ A PD + R Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCAT----ITPDEARVEEFKLKKMWLSPNGTIR 156 Query: 98 REFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVI 157 V P+ + P +P + G + R +Y + + + E+V Sbjct: 157 NILGGTVFREPI-VIPAIPRLVPGWTK---PIIIGRHAFGDQYRATDRVIPGPGKLELVY 212 Query: 158 --------QESVF--------------TRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 V+ T + +F++A + L +TK+ L Sbjct: 213 TPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNTIL 271 Query: 196 AISMPYWDERVEAM-AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGD 248 + + + + Y I ++ + ID + A+ + F ++ N GD Sbjct: 272 KRYDGRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMALKNYDGD 330 Query: 249 ILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIW 302 + SD+ G++G+ S P+ + E HG+ Y G+ + NPIA+I+ Sbjct: 331 VQSDIVAQGFGSLGLMTSTLTTPDGSAFES-EAAHGTVTRHYREHQKGRETSTNPIASIF 389 Query: 303 AGAMMLDFLGNGD--ERFQQAHNGILAA-IEEVIAHGPKTPDMK---GNA------TTPQ 350 A L G D + A IE V G T D+ G TT + Sbjct: 390 AWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKEREAWVTTRE 449 Query: 351 VADAICKIIL 360 A+ + + Sbjct: 450 YMAAVERRLK 459 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 83.4 bits (205), Expect = 1e-14, Method: Composition-based stats. Identities = 68/396 (17%), Positives = 127/396 (32%), Gaps = 74/396 (18%) Query: 1 MMKTMR---IAAIPGDGIGKEVLPEGIRVL-QAAAERWGFA---LSFEQMEWASCEYYSH 53 M K + + + GD E R++ + E+ F L + E Sbjct: 1 MSKKISGGSVVEMQGD--------EMTRIIWELIKEKLIFPYVELDLHSYDL-GIENRDA 51 Query: 54 HGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLW---------GSLLKFRREFDQYV 104 + D E + + + A PD + R V Sbjct: 52 TNDQVTKDAAEAIKKHNVGVKCAT----ITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV 107 Query: 105 NLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTR 164 R + +P ++G + R +Y + V + E+ S T+ Sbjct: 108 -FREAIICKNIPRLVSGWVK---PIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQ 163 Query: 165 RG-----------------------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPY 201 + ++ +F++A S+ L +TK+ L Sbjct: 164 KVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGR 222 Query: 202 WDERVEAM-AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLG 254 + + + + + Y +I ++ + ID + A+ + F + N GD+ SD Sbjct: 223 FKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSV 281 Query: 255 PACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAMML 308 G++G+ S + P+ E HG+ Y G+ + NPIA+I+A L Sbjct: 282 AQGYGSLGMMTSVLVCPDGK-TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGL 340 Query: 309 DFLGNGDERFQQA--HNGILAAIEEVIAHGPKTPDM 342 D + A N + E I G T D+ Sbjct: 341 AHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDL 376 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 83.4 bits (205), Expect = 1e-14, Method: Composition-based stats. Identities = 66/390 (16%), Positives = 131/390 (33%), Gaps = 58/390 (14%) Query: 2 MKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M +++ + D G E+ +V++ + + + EY + Sbjct: 7 MNKIKVKNPVVELD--GDEMTRIIWQVIKDKFIHPYLDIDLKYYDL-GLEYRDETNDQVT 63 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLW---------GSLLKFRREFDQYVNLRPVR 110 D E + ++ A PD + R V P+ Sbjct: 64 LDAAEAIKKYSVGVKCAT----ITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI- 118 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRI 170 + P +P + + + R +Y + ++ E+V + V ++ Sbjct: 119 VIPAIPRLVPSWKQ---PIIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKG-GKPEVIKV 174 Query: 171 LRYAFE--LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 + E +AQ++ K I + + EA I ++ + ID + A Sbjct: 175 YDFPAEGGVAQTQF--------KDIFQEIYEAQYRKEFEAAG-----IWYEHRLIDDMVA 221 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + + ++ N GD+ SD+ G++G+ S + P+ E HG+ Sbjct: 222 QMIKSEGGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTF-EAEAAHGTVTR 279 Query: 289 IY-----GKNIA-NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAA-IEEVIAHGPKT 339 Y G+ + NPIA+I+A L G D + A ++ V G T Sbjct: 280 HYREHQKGRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMT 339 Query: 340 PDMK---GNA------TTPQVADAICKIIL 360 D+ G TT + DA+ + + Sbjct: 340 KDLALAQGKKDRSAWVTTNEYLDAVERRLK 369 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 83.0 bits (204), Expect = 2e-14, Method: Composition-based stats. Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDG+G EV+P + VL A G SFE++ G +P + Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGV-ALDLVGVPLPKET 97 Query: 63 HEQLSRFDAIYFGAVGWP 80 + + DA+ GAVGW Sbjct: 98 LIRAKQSDALLLGAVGWY 115 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 82.3 bits (202), Expect = 2e-14, Method: Composition-based stats. Identities = 68/414 (16%), Positives = 118/414 (28%), Gaps = 79/414 (19%) Query: 16 GKEVLPEGIRVL--QAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIY 73 G+E+ ++L Q + + S+E + SC+ D E R AI+ Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDIS-SWETFDL-SCKARDDSDDATLIDAVEAGKRIGAIF 146 Query: 74 FGAVGWP-----DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDID 128 P + + RR ++ R G+ + Sbjct: 147 KEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQ------ 200 Query: 129 FYVVRENTEGEYSSLGGRVNEGT----------EHEVVIQESVFTRR------------G 166 R GEY + V EGT V+ + T + Sbjct: 201 VLFERHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPYDN 260 Query: 167 VDRILRYAFELAQSRPRKTLT--SATKSNGLAISMPYWDERVEAMAENYPEI-------- 216 V + F+ +T TK +W + Y + Sbjct: 261 VRELAHLFFKRCLEH---KVTPYIVTKKTVFKWQEGFWATMKRVFDDTYKDEFLKAGLLD 317 Query: 217 ----RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 D + + + + A N GD+L+D + G S + Sbjct: 318 RSGGELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGVS 377 Query: 273 RTFPSL---FEPVHGSAPD-----IYGKNIA-NPIATI--WAGAMM----LDFLGNGDER 317 +L FE HG+ D + GK + NP+ + GAM L++ ++ Sbjct: 378 DDGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLEYDAKPNDV 437 Query: 318 FQQ--------AHNGILAAIEEVIAHGPKTPDMKGNA--TTPQVADAICKIILR 361 + N + A+ +G T DM G TT + + R Sbjct: 438 EAKRMYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTGFTTEDFIAKVAWRLDR 491 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 81.1 bits (199), Expect = 5e-14, Method: Composition-based stats. Identities = 71/423 (16%), Positives = 128/423 (30%), Gaps = 79/423 (18%) Query: 2 MKTMRIAA------IPGDGIGKEVLPEGIRVL-QAAAERWGFALSFEQMEW--ASCEYYS 52 M +I + GD E RV+ ++ ++ +++ + Sbjct: 1 MAFQKITVQNPIVEMDGD--------EMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRD 52 Query: 53 HHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLR 107 + + E +++ A PD R + V Sbjct: 53 ATDDKVTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFRE 112 Query: 108 PV------RLFPGVPCPLA------GKQPGDIDFYV----------VRENTEGEYSSLGG 145 P+ RL PG P+ G Q D + V E + E + Sbjct: 113 PIMCKNIPRLVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGS-DEKTEFEV 171 Query: 146 RVNEGTEHEVVIQESVFTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE 204 G + S++ R + +A + L +TK+ L + + Sbjct: 172 YNFTGAG---GVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKD 227 Query: 205 RVEAMAE-------NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + + E I ++ + ID + A + + V N GD+ SD Sbjct: 228 IFQEVYEANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQG 286 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY------GKNIANPIATIWAGAMMLDFL 311 G++G+ S + P+ E HG+ Y G+ N IA+I+A L Sbjct: 287 FGSLGLMTSVLVCPDGKTI-EAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHR 345 Query: 312 GNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMK-----GN-------ATTPQVADAICK 357 D ER + AA + G T D+ G+ T + DA+ Sbjct: 346 ATLDNNERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVAD 405 Query: 358 IIL 360 + Sbjct: 406 ELK 408 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 79.2 bits (194), Expect = 2e-13, Method: Composition-based stats. Identities = 67/374 (17%), Positives = 114/374 (30%), Gaps = 58/374 (15%) Query: 36 FALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTV----PDHISLW- 90 L E + + + D E R A P+ D +W Sbjct: 67 VDLKTEYYDL-GLAHRDETDDQVTVDSAEATKRLGVAVKCATITPNAARVEEYDLKRMWK 125 Query: 91 GSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEG 150 R D V P+ + PC +P + R Y R+ Sbjct: 126 SPNGTIRAMLDGTVFRAPIVVRGIDPCVKNWVRP----ITLARHAYGDVYRDAEMRIPGP 181 Query: 151 TEHEVVIQES----------VFTRRGV-----------DRILRYAFELAQSRPRKTLTSA 189 E+V S FT GV + R F+ A + + + A Sbjct: 182 GTVELVYTASDGTETRRLVHEFTEPGVVEGMHNLDASIESFARACFDFALATSQD-VWFA 240 Query: 190 TKSNGLAISMPYWDERVEAMAE-------NYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 TK + + + + + I + ID AR + F + Sbjct: 241 TKDTISKTYDHRFKDIFQEIFDADYAARFEAAGIEYFYTLIDDAVARVMKAEGGF-IWAC 299 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA------N 296 N GD++SD+ + G++ + S +P + +E HG+ Y K++A N Sbjct: 300 KNYDGDVMSDMVSSAFGSLAMMTSVLASPHGYWE--YEAAHGTVQRHYYKHLAGEETSTN 357 Query: 297 PIATI--WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG--------NA 346 +ATI W GA+ +G + + A I G T D+ Sbjct: 358 SVATIFAWTGALRKRAELDGLADLAAFADALEQATVATIESGKMTGDLARITSIEHPTKL 417 Query: 347 TTPQVADAICKIIL 360 +T A+ + + Sbjct: 418 STGAFIKAVAEDLK 431 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 78.0 bits (191), Expect = 5e-13, Method: Composition-based stats. Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%) Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK 338 +EP GSAPDI GKNIANPIA I + AM++ + + + I +A+ + + G + Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRY----TMKLPIISDQIESAVIDTLKKGYR 66 Query: 339 TPDMKGNA----TTPQVADAICKIILR 361 T D+ + +T + D I I+ + Sbjct: 67 TLDIANDKEKCESTNDIGDIISYILKK 93 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 77.6 bits (190), Expect = 6e-13, Method: Composition-based stats. Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 2/79 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDD 61 KT +IA+IPGD IG EV+ I VL++ E + L F +++W Y GK MP D Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDW-GTARYKRTGKYMPAD 65 Query: 62 WHEQLSRFDAIYFGAVGWP 80 L F A FGAVG P Sbjct: 66 GLSTLKTFHAGIFGAVGAP 84 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 77.2 bits (189), Expect = 8e-13, Method: Composition-based stats. Identities = 30/106 (28%), Positives = 48/106 (45%), Gaps = 7/106 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQA-AAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M T I + GDGIG E+ E ++VL A + ++ F L E ++ S + G + Sbjct: 360 MTTHTILVLRGDGIGLEITAEAVKVLSAFSLKKRTFDLRSELIDGCSIDT---DGTPITK 416 Query: 61 DWHEQLSRFDAIYFGAVG---WPDTVPDHISLWGSLLKFRREFDQY 103 + DA+ F +VG W D G LL+ R+ +Q+ Sbjct: 417 TVIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 72.6 bits (177), Expect = 2e-11, Method: Composition-based stats. Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 6/67 (8%) Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 IANP A + + ML + Q I AI EV+A G +T D+ G+++T + Sbjct: 155 IANPTAMLMCASKMLRHV-----NLQHYSESIRNAIREVLAAGKVRTRDLGGSSSTHEFT 209 Query: 353 DAICKII 359 DA+ K I Sbjct: 210 DAVIKAI 216 Score = 61.5 bits (148), Expect = 4e-08, Method: Composition-based stats. Identities = 24/103 (23%), Positives = 42/103 (40%), Gaps = 8/103 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + IPGDG+ E++ VL+A G + FE + ++ + H +D Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAI----GAPIDFETILFSEVQ---HSSSAKVEDV 115 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVN 105 + ++R GA+ PD L +K R+ D N Sbjct: 116 IKSINRNRICLMGALMSPDVSYSG-ELQNLHMKLRKGLDLIAN 157 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 71.9 bits (175), Expect = 4e-11, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 8/82 (9%) Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 GSAPDI GKNIANPIA I + AM++ + + + + I +++ + + G KT D+ Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRY----TMKLHKIADDIESSVIDALKKGYKTLDIA 57 Query: 344 G----NATTPQVADAICKIILR 361 + +T + D I I+ + Sbjct: 58 NVNETHISTSDMGDVISNILNK 79 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 63.4 bits (153), Expect = 1e-08, Method: Composition-based stats. Identities = 65/402 (16%), Positives = 120/402 (29%), Gaps = 75/402 (18%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I + GD E+ R+++ L + + + K+ + L Sbjct: 87 IVEMDGD----EMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDKVTVESAEATL 142 Query: 67 SRFDAIYFGAVGWPDTVPDHISL----WGSLLKFRREFDQYVNLRPV------RLFPGVP 116 A+ + +T L R + V P+ R+ PG Sbjct: 143 KYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCLNIPRIVPGWK 202 Query: 117 CPLAGKQ----------------PGDIDFYVVRE--NTEGEYSSLGGRVNEGTEHEVVIQ 158 P+ + PG + V E NT L V + V + Sbjct: 203 KPICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNT-----PLELDVYDFKGPGVALA 257 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN-----Y 213 + + + LA + + L +TK+ L + + + + E + Sbjct: 258 MYNVDQS-IRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKQKF 315 Query: 214 PE--IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 E I ++ + ID + A V + V N GD+ SD + A Sbjct: 316 EEHSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEAEAAHGT 367 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAI 329 LF+ ++ N IA+I+A L+ D E + + + Sbjct: 368 VTRHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVHKLEGSC 419 Query: 330 EEVIAHGPKTPDMK----GN-------ATTPQVADAICKIIL 360 E + G T D+ G T + DA+ + + Sbjct: 420 IETVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLE 461 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 62.6 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 31/96 (32%), Positives = 44/96 (45%), Gaps = 9/96 (9%) Query: 94 LKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEH 153 LK + D YV R FPG C +D ++ +N G ++ L EG Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFP-----GVDIQLIGQNNMGIFNELEYSPVEG--- 183 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSA 189 VV SV +++G D+ LRYAF+ A RK +T Sbjct: 184 -VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 62.6 bits (151), Expect = 2e-08, Method: Composition-based stats. Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 3/79 (3%) Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP 340 P+HG APDI G IANP A + A +L G +E QQ N I +A E TP Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGY-EELAQQVENQIESAFYE--NRDQTTP 265 Query: 341 DMKGNATTPQVADAICKII 359 D G T + + + I Sbjct: 266 DQGGVLNTEKYMAMMVECI 284 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 59.9 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 1/61 (1%) Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHG 336 +FEP HGSAPDI G+NIANPIA IW+GA ML G + A + V+ Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHRHPSAAGHGANKAVMIDA 60 Query: 337 P 337 Sbjct: 61 T 61 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 58.8 bits (141), Expect = 3e-07, Method: Composition-based stats. Identities = 15/52 (28%), Positives = 26/52 (50%), Gaps = 1/52 (1%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG 55 + +I +PGDGIG E++ E ++VL+ A E++ + HG Sbjct: 9 SKQILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTH-DVIGGAAIDKHG 59 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 58.8 bits (141), Expect = 3e-07, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 31/77 (40%), Gaps = 5/77 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ IPGDGIG E+ ++ +AA + ++ ++ + + +P E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA----NAPIEWDPVDVTPVKGDDGIFR-IPSKCIEL 81 Query: 66 LSRFDAIYFGAVGWPDT 82 + G + P+ Sbjct: 82 MRINKIGLKGPLATPNW 98 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 58.0 bits (139), Expect = 5e-07, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 28/82 (34%), Gaps = 7/82 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + IPGDGIG E+ + + + +EQ + G+ + E Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYV----NAPIEWEQYNVSGMS---SAGEDLFKQAVE 61 Query: 65 QLSRFDAIYFGAVGWPDTVPDH 86 L R G + P + H Sbjct: 62 SLRRNRVGLKGILFTPISQSGH 83 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 56.8 bits (136), Expect = 1e-06, Method: Composition-based stats. Identities = 28/104 (26%), Positives = 36/104 (34%), Gaps = 31/104 (29%) Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 +GP +G+ L E ++Y KNIANP AT+ A MMLD L Sbjct: 25 VGPELMAAVGVIECLKLGDGLFLQCCEEVA-----ELYPKNIANPTATLLASCMMLDHL- 78 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 KT DM G AT +A+ Sbjct: 79 -------------------------KTSDMGGYATCQDFTEAVI 97 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 56.4 bits (135), Expect = 2e-06, Method: Composition-based stats. Identities = 27/92 (29%), Positives = 41/92 (44%), Gaps = 10/92 (10%) Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L G QP ++ +V EN EGEYS GR + E++I + + A++ Sbjct: 81 SSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG---------LSKIAYQ 131 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 L + P K + ATKSN + W+E Sbjct: 132 LLRG-PEKHIAIATKSNAQRNGLVIWNEVAAE 162 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 56.1 bits (134), Expect = 2e-06, Method: Composition-based stats. Identities = 18/61 (29%), Positives = 27/61 (44%), Gaps = 6/61 (9%) Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + A +MLD L + N I +AI + T D+ G TT +V +I +I Sbjct: 1 MLLASCLMLDHL-----KLHDYANMIRSAILTTMNETRLHTVDIGGQGTTSEVVQSIMRI 55 Query: 359 I 359 I Sbjct: 56 I 56 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 54.5 bits (130), Expect = 6e-06, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 27/45 (60%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY 50 +I A+ GDGIG E++ G+ VL+A AE+ GF ++ + + Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGADI 48 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 54.1 bits (129), Expect = 7e-06, Method: Composition-based stats. Identities = 18/75 (24%), Positives = 29/75 (38%), Gaps = 11/75 (14%) Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNA 346 NIANP + A ML ++G I A + + G T D+ K Sbjct: 6 NIANPSGLLNAAVHMLIYIGQVGT-----AKLIYDAWLKTLEGGIHTADLYKEKRSKQKV 60 Query: 347 TTPQVADAICKIILR 361 T + A+A+ + + Sbjct: 61 GTKEFAEAVIDNLGK 75 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 51.8 bits (123), Expect = 4e-05, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 110/356 (30%), Gaps = 80/356 (22%) Query: 2 MKTMRIAAIPGD--GIGKEVLPEGI---RVLQAA--------------AERWGFALSFEQ 42 M +IA IPGD GIG E++ + + V +AA A + G L + Sbjct: 6 MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65 Query: 43 MEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQ 102 + WA+ + + E + D S +L + D Sbjct: 66 IAWANLAEF----SGLRQLEMETIDVADV--------KVAEVTIQSGKSALRTLDQALDL 113 Query: 103 YVN--LRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE------YSSLGGRVNEGTEHE 154 V + V P L N E E Y G +E + Sbjct: 114 AVAGIVDGVLFGPFNKAALTAAGL----------NAEDEHRYMARYLGFKGYHSEVNVLD 163 Query: 155 VVIQESV------------FTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPY 201 ++ V T GV + + A + + A + N A Sbjct: 164 DLMTTRVTSHIGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGK 223 Query: 202 W-DERVEAMAENYPEIRWDKQHID----ILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + E ++ +A E + H+ + D VV ++ D + Sbjct: 224 FGREEIDILAPVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIK 280 Query: 257 CTG---TIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLD 309 G + +A + + P HG+A DI G+++AN AT A ++L Sbjct: 281 LMGFDRGVTVAGGLPI-------PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLR 329 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 51.4 bits (122), Expect = 5e-05, Method: Composition-based stats. Identities = 5/33 (15%), Positives = 17/33 (51%) Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 +T K+N + ++ + +A+++P++ Sbjct: 79 KVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 49.1 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 16/34 (47%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALS 39 + IPGDGIG E+ +++ AA + Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVR 39 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 48.4 bits (114), Expect = 5e-04, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 27/80 (33%), Gaps = 3/80 (3%) Query: 170 ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN---YPEIRWDKQHIDIL 226 +R A + + L A K N + + + E+ I W ID + Sbjct: 160 FVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAAETLESLAGAAGIAWRSLIIDHM 219 Query: 227 CARFVMQPERFDVVVASNLF 246 A V P + ++ + F Sbjct: 220 AAELVRNPLDYRAILTHSSF 239 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 48.0 bits (113), Expect = 6e-04, Method: Composition-based stats. Identities = 14/28 (50%), Positives = 21/28 (75%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAER 33 +I A+ GDGIG E++ G+ VL+A AE+ Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEK 31 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 43.0 bits (100), Expect = 0.017, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 52/174 (29%), Gaps = 22/174 (12%) Query: 190 TKSNGLAISMPYWDERVEAMAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASN-- 244 K N + + + + E I + ID + A P+ + ++ Sbjct: 3 HKGNSIKYTDGLFAVVAKQELEKLIGDSGIIQESLIIDHMAAELTRNPQDYRAILTHGAF 62 Query: 245 -------LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP--DIYGKNIA 295 L G + +D G C TIG A + +L H AP + G+ Sbjct: 63 AELLAALLDGQLDTDAGGVCR-TIGTARRPLFGYD---VALDPARHTRAPEAEAAGRLR- 117 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 + + AG+++ D L G T + A T Sbjct: 118 ---SVLLAGSLLADHLDQGVAAAGIRAAADALDAPATADGHAGTAGLAACARTA 168 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 43.0 bits (100), Expect = 0.018, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 16/40 (40%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE 41 ++ PGDGIG E+ +V AA + F Sbjct: 41 STPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFV 80 >UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis RepID=A7IS87_NEIME Length = 44 Score = 42.6 bits (99), Expect = 0.024, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 1/44 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS 47 T IA + GDGIG E++ E +RVL + G +E Sbjct: 2 TKHIAILRGDGIGSEIVAETVRVLDKLIAQ-GLDAGYEYAPLGG 44 >UniRef50_P41566 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3G_PIG Length = 106 Score = 42.2 bits (98), Expect = 0.032, Method: Composition-based stats. Identities = 14/20 (70%), Positives = 15/20 (75%) Query: 292 KNIANPIATIWAGAMMLDFL 311 KNIANP AT+ A MMLD L Sbjct: 86 KNIANPTATLLASCMMLDHL 105 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 42.2 bits (98), Expect = 0.032, Method: Composition-based stats. Identities = 9/25 (36%), Positives = 13/25 (52%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQ 28 + IPGDGIG E++ V + Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFR 136 >UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q0V0_9BACT Length = 346 Score = 41.8 bits (97), Expect = 0.041, Method: Composition-based stats. Identities = 15/30 (50%), Positives = 17/30 (56%), Gaps = 3/30 (10%) Query: 281 PVHGSAPDIYGKNIANPIAT---IWAGAMM 307 P HG+A DI GK IANP + I MM Sbjct: 310 PDHGTAYDIAGKGIANPDSMKEAIMTAIMM 339 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 434 e-120 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 432 e-119 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 413 e-114 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 406 e-112 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 404 e-111 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 396 e-109 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 395 e-108 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 390 e-107 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 390 e-107 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 389 e-107 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 389 e-107 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 388 e-106 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 388 e-106 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 387 e-106 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 386 e-106 UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 383 e-105 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 383 e-105 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 381 e-104 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 380 e-104 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 380 e-104 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 378 e-103 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 377 e-103 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 377 e-103 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 377 e-103 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 376 e-103 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 375 e-102 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 375 e-102 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 374 e-102 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 373 e-102 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 372 e-101 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 372 e-101 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 370 e-101 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 370 e-101 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 369 e-101 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 368 e-100 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 368 e-100 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 368 e-100 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 367 e-100 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 366 e-100 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 366 e-100 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 365 1e-99 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 365 2e-99 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 365 2e-99 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 364 2e-99 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 364 3e-99 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 364 3e-99 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 363 5e-99 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 363 5e-99 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 363 8e-99 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 360 6e-98 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 359 8e-98 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 358 1e-97 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 358 2e-97 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 357 4e-97 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 354 2e-96 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 354 3e-96 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 353 8e-96 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 352 1e-95 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 352 1e-95 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 350 6e-95 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 349 1e-94 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 349 1e-94 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 348 1e-94 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 348 3e-94 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 347 4e-94 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 347 5e-94 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 346 6e-94 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 346 9e-94 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 346 1e-93 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 345 2e-93 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 344 4e-93 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 343 4e-93 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 343 8e-93 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 341 2e-92 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 341 3e-92 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 340 4e-92 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 340 5e-92 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 340 5e-92 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 340 5e-92 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 339 6e-92 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 339 1e-91 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 338 2e-91 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 338 3e-91 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 337 4e-91 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 336 8e-91 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 336 9e-91 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 334 4e-90 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 333 7e-90 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 332 1e-89 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 331 3e-89 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 331 3e-89 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 330 5e-89 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 329 6e-89 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 329 1e-88 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 327 4e-88 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 327 4e-88 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 326 7e-88 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 326 8e-88 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 326 1e-87 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 326 1e-87 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 325 2e-87 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 324 3e-87 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 323 6e-87 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 323 7e-87 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 322 1e-86 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 321 2e-86 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 320 4e-86 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 319 1e-85 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 318 2e-85 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 315 1e-84 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 315 2e-84 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 315 2e-84 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 314 4e-84 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 313 5e-84 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 313 6e-84 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 313 7e-84 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 313 7e-84 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 313 8e-84 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 313 1e-83 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 313 1e-83 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 309 9e-83 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 308 3e-82 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 307 3e-82 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 307 5e-82 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 304 3e-81 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 304 4e-81 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 303 1e-80 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 302 1e-80 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 302 2e-80 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 300 4e-80 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 297 5e-79 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 295 2e-78 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 294 3e-78 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 293 5e-78 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 289 8e-77 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 287 3e-76 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 287 3e-76 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 287 4e-76 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 282 1e-74 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 276 1e-72 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 276 1e-72 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 275 1e-72 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 272 9e-72 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 272 2e-71 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 271 4e-71 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 268 2e-70 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 266 8e-70 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 264 3e-69 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 260 6e-68 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 258 3e-67 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 258 3e-67 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 256 1e-66 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 255 2e-66 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 255 2e-66 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 251 3e-65 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 246 8e-64 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 243 8e-63 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 242 2e-62 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 236 1e-60 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 230 5e-59 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 230 6e-59 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 229 1e-58 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 211 3e-53 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 210 4e-53 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 200 6e-50 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 196 9e-49 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 195 2e-48 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 192 1e-47 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 191 4e-47 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 189 1e-46 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 185 2e-45 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 182 1e-44 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 182 2e-44 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 181 4e-44 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 181 4e-44 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 180 5e-44 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 171 4e-41 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 171 4e-41 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 170 7e-41 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 166 1e-39 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 166 1e-39 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 163 8e-39 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 163 9e-39 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 160 8e-38 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 147 5e-34 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 142 2e-32 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 141 3e-32 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 139 2e-31 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 133 1e-29 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 129 2e-28 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 126 2e-27 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 121 4e-26 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 113 1e-23 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 105 4e-21 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 100 1e-19 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 98 6e-19 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 97 7e-19 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 94 6e-18 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 93 1e-17 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 93 2e-17 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 85 4e-15 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 84 6e-15 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 83 1e-14 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 81 6e-14 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 80 1e-13 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 75 3e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 75 3e-12 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 73 1e-11 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 72 4e-11 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 68 4e-10 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 65 3e-09 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 65 4e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 65 4e-09 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 64 1e-08 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 62 4e-08 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 60 1e-07 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 57 1e-06 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 55 3e-06 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 55 3e-06 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 50 2e-04 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 50 2e-04 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 47 0.001 Sequences not found previously or not previously below threshold: UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 132 2e-29 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 82 3e-14 UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 49 3e-04 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 46 0.002 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 45 0.004 UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Ta... 45 0.007 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 44 0.008 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 44 0.009 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 44 0.009 UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 42 0.027 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 42 0.031 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 42 0.033 UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n... 42 0.034 UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic prot... 41 0.053 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 434 bits (1116), Expect = e-120, Method: Composition-based stats. Identities = 278/363 (76%), Positives = 311/363 (85%), Gaps = 2/363 (0%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIAAIPGDGIG EVLPEGIRVL+AAA + G AL F+ EWASC+YY HGKMMP Sbjct: 1 MPAHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMP 60 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW EQL ++DAIYFGAV WPD VPDHISLWGSLLKFRREFDQYVN+RPVRLFPGVPC L Sbjct: 61 DDWAEQLKQYDAIYFGAVDWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCAL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 A ++ GDIDF VVRENTEGEYSSLGG + E TE+E+VIQES+FTRRGVDRIL+YAF+LA+ Sbjct: 121 ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAFDLAE 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD- 238 R RK +TSATKSNG+AISMPYWD+R EAMA +YP + WDKQHIDILCARFV+QPERFD Sbjct: 181 KRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPERFDV 240 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 VVVASNLFGDILSDLGPAC GTIGIAPSANLNPER FPSLFEPVHGSAPDI+GKNIANPI Sbjct: 241 VVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNIANPI 300 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A IW+GA+ML+FLG GDER+Q+AH+ +L AIE VIA G TPDM G +T QV AI Sbjct: 301 AMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDMGGTLSTQQVGAAISDT 360 Query: 359 ILR 361 + R Sbjct: 361 LAR 363 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 432 bits (1110), Expect = e-119, Method: Composition-based stats. Identities = 254/360 (70%), Positives = 298/360 (82%), Gaps = 2/360 (0%) Query: 1 MMKT-MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + RIA IPGDGIG EV+PEG+R L A + R+G ++E +EWASC+YY+ HG+MMP Sbjct: 36 MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP 95 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 DDW QLS DA+ FGAVGWP+TVPDHISLWGSL+KFRREFDQYVNLRP RLF GVPCPL Sbjct: 96 DDWKTQLSGMDALLFGAVGWPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVPCPL 155 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 AG++ GDIDF +VRENTEGEYS++GG + EGTE E V+Q++VFTR G +R+L++AFELAQ Sbjct: 156 AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFAFELAQ 215 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R K LT ATKSNG+AISMP+WD R MA YP++ WDKQHIDILCARFVMQP+RFDV Sbjct: 216 RRA-KRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPDRFDV 274 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 VVASNLFGDILSDLGPACTGTIGIAPSANLNPER FPSLFEPVHGSAPDI GK+IANPIA Sbjct: 275 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIANPIA 334 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 IW+ AMM+DFLG G ++AH+ I+AAIE V+ HGP+T DM G A+T +V DAI + Sbjct: 335 MIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRASTREVGDAIVAHL 394 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 413 bits (1061), Expect = e-114, Method: Composition-based stats. Identities = 223/359 (62%), Positives = 268/359 (74%), Gaps = 9/359 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +IA IPGDGIG EV+PEGIRVL+AA+ ++GF L+F +W SC Y G MMP D Sbjct: 5 QQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDW-SCARYHSQGSMMPSDG 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L DAI+ GAVG+P VPDH+SLW L+ RREFDQYVNLRPVRL PGVPCPLA K Sbjct: 64 IERLRDSDAIFLGAVGFP-GVPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPLANK 122 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +PGDIDF++VRENTEGEYS +GGR+ GTEHE V QE++FTRRG DRI+RYAF+LA+ Sbjct: 123 KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFDLAKKLG 182 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +TSATKSNG+ SMP+WDER A+ YP+IR D+ HIDIL ARF M PERFDVVV Sbjct: 183 RNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPERFDVVVG 242 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDLGP TGTI +APSAN+NPER +PS+FEPVHGSAPDI G+ IANPI IW Sbjct: 243 SNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIANPIGQIW 302 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA--HGPKTPDMKGNATTPQVADAICKII 359 +GAMML+ LG +A I+ AIE V+ TPD+ G A+T Q+ I + + Sbjct: 303 SGAMMLEHLGQ-----PEAAAAIMQAIETVLTHPDRVHTPDLGGRASTQQMGAEIARAV 356 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 406 bits (1044), Expect = e-112, Method: Composition-based stats. Identities = 181/360 (50%), Positives = 243/360 (67%), Gaps = 8/360 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 M+ +IAAIP DGIG EV+ G++VL+A +R G F++ E +W +YY +G MMP Sbjct: 1 MREYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDW-GSDYYKKNGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL +FDAI+FGAVG PD VPDHI+LWG L + FDQY N+RP ++ PG+ PL Sbjct: 60 DGLEQLKKFDAIFFGAVGAPD-VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITPPLR 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 PGD+D+ +VREN+EGEYS GGR ++G EV + ++FTR GV RI+RYAF+LAQ+ Sbjct: 119 NCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFKLAQA 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN M WDE +++ +P++ WDK +D + R ++P+ D + Sbjct: 179 RPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQSLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++G+AP+AN++PER FPS+FEP+HGSA DI GK IANP+AT Sbjct: 239 VATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIANPVAT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W A ML+ LG D A +++A+E V G TPD+ G A T QV DA+C+ I Sbjct: 299 FWTAAQMLEHLGEKD-----AATRLMSAVERVTEAGILTPDVGGTADTQQVTDAVCEAIA 353 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 404 bits (1039), Expect = e-111, Method: Composition-based stats. Identities = 173/359 (48%), Positives = 231/359 (64%), Gaps = 9/359 (2%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDDW 62 T RIA+IPGDGIG EV+ I+V++ A+ G F + F + W YY HG+ + +D Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPW-GTAYYKEHGRYVSEDC 104 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L +FDA FGAVG PD VPDHISLWG LL R Y N+RPVR FPG CPL Sbjct: 105 LDTLRKFDAGLFGAVGAPD-VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPL-NT 162 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ +VREN+EGEYS GGR + G E + ++FTR G++RI+R+AFE+AQSRP Sbjct: 163 ATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEVAQSRP 222 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK LT TKSN + M WD+ +A+++P++ WDK +D + R V +P+ D +V Sbjct: 223 RKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSIDTIVG 282 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NL DILSDL A G+IG+APS+NL+P R PS+FEPVHGSA DI GK +ANP+AT W Sbjct: 283 TNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANPVATFW 342 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 + A ML +LG ++A ++ +E+V A G TPD+ G + T V DA+ K I R Sbjct: 343 SAAEMLSWLGE-----KEAAKQLMDCVEKVCAAGILTPDLGGTSNTQGVVDAVKKEIER 396 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 396 bits (1018), Expect = e-109, Method: Composition-based stats. Identities = 179/362 (49%), Positives = 229/362 (63%), Gaps = 9/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPD 60 MKT RIA IPGDGIGKEV+P G + +Q AE G F F+ +W +YY HG MMP Sbjct: 1 MKTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGG-DYYRRHGVMMPA 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E L DAI FG+ G PD DHI+LWG LK + DQY N+RP RL PG+ PL Sbjct: 60 DGLEPLRDKDAILFGSAGDPDIA-DHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPLK 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D+ +VREN+EGEYS +GGRV++G E S+ TR GV+RILRYAF LAQS Sbjct: 119 RCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFRLAQS 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK LT TKSN +M WDE ++ +P++RWDK+ +D AR V +P D + Sbjct: 179 RPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPASLDTI 238 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VA+NL DILSDL A G++GIAP+ N++PER PS+FEP+HGSA DI GK +ANPI T Sbjct: 239 VATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLANPIGT 298 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 W+ M+L+ LG QA ++ A+E V A T D+ G ATT QV A+C+ + Sbjct: 299 FWSVVMLLEHLGE-----HQAAARMMRAVESVTADQALHTRDLGGTATTEQVTQAVCQHL 353 Query: 360 LR 361 + Sbjct: 354 RQ 355 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 395 bits (1016), Expect = e-108, Method: Composition-based stats. Identities = 176/362 (48%), Positives = 241/362 (66%), Gaps = 10/362 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M+ RIA +PGDGIG EV+ E ++VL+ ++ + F + W S EYY HG+MMP+ Sbjct: 1 MREFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNS-EYYLQHGRMMPE 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + L +DAI FGA+G P VPD IS+W ++ R+ F QYVNLRPV+ G+P Sbjct: 60 NGLDILKNYDAILFGAIGDPR-VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQFI 118 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 Q I+F +VREN EGEYS+ GGR+ +GT+ E+ +Q ++ TR+G +RI RYAF+ A+ Sbjct: 119 -HQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQYAKK 177 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + + +ATKSN + SM WDE +E +A YP+I+ +K +ID L A FV +P+ V+ Sbjct: 178 HGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDTLQVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDLG A G +GI+PSAN+NPE FPS+FEPVHGSAPDI GK ANPIA Sbjct: 238 VASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKANPIAQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 IW+ A+ML LG D + IL AIE+V HG T D+ GN+TT ++ + I + I Sbjct: 298 IWSAALMLQSLGRED-----LASIILKAIEKVTEHGEKLTEDLGGNSTTAEMGEEIVRQI 352 Query: 360 LR 361 ++ Sbjct: 353 VK 354 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 104/357 (29%), Positives = 167/357 (46%), Gaps = 27/357 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +A IPGDGIG E+ + + A + +E ++ + MP + Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTPRPTEDGRFR-MPQSSLDI 2032 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+EF+ Y N+RP + G P Sbjct: 2033 IRKHGIGLKGPLATPI----GKGHQSLNLALRKEFNLYANVRPCKSIEGYETPYK----- 2083 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ++D VRENTEGEYS + + +G VV + T R+ R+AF+ A+ R++ Sbjct: 2084 NVDLVTVRENTEGEYSGIEHVIVDG----VVQSIKLITEEASRRVARFAFQYAKDNGRRS 2139 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + A ++ EI + +D +C V P RFDV+V NL Sbjct: 2140 VTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVLVMPNL 2199 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI G++ ANP A +++ Sbjct: 2200 YGDILSDLAAGLIGGLGVTPSGNIGETG---AIFESVHGTAPDIAGQDRANPTALLFSAI 2256 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 MML ++ + + I +A+ I T D+ G +T Q IC+ I + Sbjct: 2257 MMLRYM-----NLNKHADLIESAVLATIREAKYLTADLGGRSTCSQYTKEICRQIEQ 2308 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 390 bits (1003), Expect = e-107, Method: Composition-based stats. Identities = 126/357 (35%), Positives = 180/357 (50%), Gaps = 27/357 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T +I IPGDGIG EV +RVL+A G +E A E Y + + +P + + Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA----TGLKFEWESFA-AGAEAYEKYKEYIPKELN 56 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G V P ++ R+ F+ Y N+RP+R PGV Sbjct: 57 ESIERTRIGLKGPVTTPI----GGGFSSINVELRKRFELYANVRPIRNLPGVHTRY---- 108 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +D VVRENTEG YS + V G VV + T + RI ++AF A+ R Sbjct: 109 -PGVDLVVVRENTEGLYSGIEHEVVPG----VVESLKIITEKASTRISKFAFNYARKMGR 163 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K + S K+N + +S + +++ YPEI + + +D C + VM P ++D+++ Sbjct: 164 KKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYDILLLE 223 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SDL G +G+AP AN+ S+FE VHGSAPDI GKNIANP A I + Sbjct: 224 NLYGDIVSDLCAGLVGGLGLAPGANIGER---ASIFEAVHGSAPDIAGKNIANPTAVIRS 280 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 G +ML L D A N + AA+ V G T DM G +T + AD + + I Sbjct: 281 GILMLRHLDEQD-----AANRVKAAVHHVYREGKHLTRDMGGTTSTSEFADKVVEAI 332 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 389 bits (1000), Expect = e-107, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 182/355 (51%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIGKEV+ + +L+ + + A E +GK +PD+ E Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILEKL----DLPFEYSYYD-AGDEALEKYGKALPDETLEA 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA+ FGA G +++ RRE + N+RP + G+ C Sbjct: 58 CRKSDAVLFGAAGETAA--------DVIVRLRRELGTFANVRPAKAIEGIECLY-----P 104 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D VVRENTE Y +V V TR +RI RYAFELA+ RK Sbjct: 105 GLDIVVVRENTECLYMGFEFGFG-----DVTEAIRVITREASERIARYAFELAKREGRKK 159 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A++YPEI+++ +ID C VM P RFDV+V +N+ Sbjct: 160 VTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVIVTTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDI+SDL G +G+APSAN+ ++FEPVHG+A DI GK IANP A I Sbjct: 220 FGDIVSDLAAGLVGGLGLAPSANVGER---TAIFEPVHGAAFDIAGKGIANPTAMILTAC 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML G +E + A+E+ I G KTPD+ GN T + A+ + ++ Sbjct: 277 MMLRHFGYVEE-----AKKVEEAVEKTIKEGKKTPDLGGNLKTMEFANEVASLLD 326 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 389 bits (1000), Expect = e-107, Method: Composition-based stats. Identities = 187/361 (51%), Positives = 244/361 (67%), Gaps = 11/361 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IAAIPGDG+GKEV+ +VL AAE G + SF W SC+YY HGKMMP+ Sbjct: 3 MKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPW-SCDYYLEHGKMMPE 61 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L++F+A++ GAVG P VPDHISLWG LLK RRE + +N+RP + G+ PL Sbjct: 62 DGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPL- 120 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 P D DF V+REN+EGEYS +GGR++ G + E+ IQ +VFTR+ +R++R+AFELA+ Sbjct: 121 -LHPNDFDFVVIRENSEGEYSEVGGRIHRG-DDEIAIQNAVFTRKATERVMRFAFELAKK 178 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R +TSATKSNG+ +MP+WDE + A +Y I QHID L A FV +PE FDV+ Sbjct: 179 R-RSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETFDVI 237 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDIL+D+ + G+IGIAPSAN+NP +PS+FEPVHGSAPDI G+ +ANPI Sbjct: 238 VASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANPIGQ 297 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 IW +MLD G ++ IL +E+V A G KT D+ G +TT +V D IC + Sbjct: 298 IWTAKLMLDHFGE-----EELGAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEICSRLR 352 Query: 361 R 361 + Sbjct: 353 K 353 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 111/359 (30%), Positives = 170/359 (47%), Gaps = 32/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ IPGDGIG E+ RV A +EW + ++ G + + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKA---------PIEWETVVVDANTG--ISKE 69 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E +S+ G + P L R+ F+ Y N+RP PG Sbjct: 70 VIESISKNKIGLKGPISTPI----GTGHQSLNLGLRKTFNLYANIRPCLSIPGHKTRY-- 123 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +++ VVRENTEGEYS + + +G V + T+ RI YAF+ A + Sbjct: 124 ---NNVNTVVVRENTEGEYSGIENQPVKG----VAQSIKIITKEASTRIAHYAFQYALAN 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T K+N + S + + ++ YP I++++ ID C + V+ P + DV+V Sbjct: 177 GRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQMDVMV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDI+SDL G +G+ PS N+ + ++FE VHG+APDI GKN ANP A I Sbjct: 237 LPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGS--AIFEAVHGTAPDIAGKNKANPTALI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + MML LG+ E + I A+ + G T D+ GN++ + D + K I Sbjct: 295 LSSIMMLRHLGHFHE-----ASIIENAVLNTLTEGKVKTGDLGGNSSCSEYTDELVKKI 348 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 388 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 180/359 (50%), Positives = 218/359 (60%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ IA IPGDGIG++V +VL A GF L+ W SC +Y G MMP D Sbjct: 1 MKSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPW-SCAFYKETGAMMPPD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L RFDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL GV PL Sbjct: 60 GIETLRRFDAILLGAVGWPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKGPLK- 118 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV++GT EV ++ S+FTR GV+RILR+ F+ A+ R Sbjct: 119 --AEGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQARQR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ L S TKSN SM WDE +A YP++ HID + AR VM PE DVVV Sbjct: 177 -RRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLDVVV 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMMLD LG +A ++ A+E A G T G T + A+ + Sbjct: 296 WSGAMMLDHLGQ-----ARAARKVIEALERTTARGIGTVP--GKNRTETITAAVLAALD 347 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 108/361 (29%), Positives = 181/361 (50%), Gaps = 24/361 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M I+ + GDGIG E+ + +L+A + + +L +++E A + GK +PD Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLE-AGDAVLKNTGKALPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + E + DA VG S ++ RR D Y N+RP + +P +P Sbjct: 60 ETFEAIKNSDACLKAPVG--------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL-- 109 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 D+D +VRENTE Y+ + + + + + + RI YAF +A Sbjct: 110 ---RDDVDLVIVRENTEDLYTGEEFDIG-----DAAVAFRIISEKASKRIANYAFTIASK 161 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R K +T KSN + + + +A ++P++++++ ++D + QP+ FDV+ Sbjct: 162 RKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQLFDVI 221 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDILSD G +G+AP+AN+ LFEPVHG+A DI GK IANP + Sbjct: 222 VTTNLFGDILSDESAQVVGGLGMAPAANIGDN---FGLFEPVHGAAFDIAGKQIANPTSF 278 Query: 301 IWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 I + MMLD+LG + D++ + + + +++ + KT D+ G+ TT + I Sbjct: 279 ILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGDKTTMEFTKEIISR 338 Query: 359 I 359 + Sbjct: 339 L 339 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 386 bits (992), Expect = e-106, Method: Composition-based stats. Identities = 167/361 (46%), Positives = 220/361 (60%), Gaps = 11/361 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +IA IPGDG G E + EG++VL AAA + GFAL ++W EYY G+++P Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGG-EYYLRTGEVLPP 71 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D EQL R+DAIY GA+G P+ P I G LL+ R E DQY+NLRPV+L+PGV P+A Sbjct: 72 DAVEQLKRYDAIYLGAIGHPEVRP-GILEKGILLRLRFELDQYINLRPVKLYPGVETPIA 130 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 GK P DIDF VVRENTEG Y+ GG + GT EV IQ S+ TR+GV+R +R+AFE + Sbjct: 131 GKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAFEYCRK 190 Query: 181 R-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R+ +T K+N L + W+ + E YP+I D H+D +C V PE FDV Sbjct: 191 RGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNPEWFDV 250 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDI++DLG G +GIA NLNPE S+FEP+ GSAP GKN+ NP+A Sbjct: 251 IVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPE--GVSMFEPIGGSAPKYTGKNVINPLA 308 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA-TTPQVADAICKI 358 + AGAMML+ LG A I A+++V A K+ T +V D + Sbjct: 309 AVCAGAMMLEQLGETG-----AAARIEEAVKKVCAGHLKSLAAGRMGYGTDEVGDLVVSH 363 Query: 359 I 359 + Sbjct: 364 L 364 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 133/367 (36%), Positives = 192/367 (52%), Gaps = 18/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M++ +A + GDGIG EV+ E ++VL E++GF L+F + H G +P + Sbjct: 1 MQSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGG-AAIDHCGYPLPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP-- 116 + DAI FG+VG P PD G+LL R+ F + NLRP L+ G+ Sbjct: 60 TLKGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKF 119 Query: 117 CPLAGKQP-GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 CPL D VVRE T G Y V+ + ++RI R AF Sbjct: 120 CPLRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAF 179 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A R K +TS K+N L S+ W E V MA++YPE+ + +ID + + PE Sbjct: 180 EAAMKRN-KKVTSVDKANVLQSSI-LWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPE 237 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDV++ SN+FGDI+SD TG++G+ PSA+LN L+EP GSAPDI GK IA Sbjct: 238 SFDVLLCSNIFGDIISDEAAMITGSMGMLPSASLNE--AGFGLYEPAGGSAPDIAGKGIA 295 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT---TPQVA 352 NPIA I + AMML + +A + I +A+++V+A G +T D+ ++T T ++ Sbjct: 296 NPIAQILSAAMMLRY----SFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMG 351 Query: 353 DAICKII 359 I + I Sbjct: 352 TLITQAI 358 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 383 bits (984), Expect = e-105, Method: Composition-based stats. Identities = 126/366 (34%), Positives = 188/366 (51%), Gaps = 29/366 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 MM ++ I GDGIGKEV+PE I++L E A E +G +P+ Sbjct: 1 MM---KVCVIEGDGIGKEVIPEAIKILNELGEFEIIKGE------AGLECLKKYGNALPE 51 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP-----GV 115 D E+ D I FGA+ P + + ++ R+ F Y N+RP+ F G Sbjct: 52 DTIEKAKEADIILFGAITSPK-PGEVKNYKSPIITLRKMFHLYANVRPINNFGIGQLIGK 110 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 +ID ++RENTE Y E++ I E V TR+G +RI+R+AF Sbjct: 111 IADYEFLNAKNIDIVIIRENTEDLYVGRER-----LENDTAIAERVITRKGSERIIRFAF 165 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A RK ++ K+N L I+ + E + ++Y I D +D + PE Sbjct: 166 EYAIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPE 224 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 +FDV+V +N+FGDILSD A G +G+APSAN+ ++ +LFEPVHGSAPDI GK IA Sbjct: 225 KFDVIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK---ALFEPVHGSAPDIAGKGIA 281 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 NP+A+I + AM+ D++G ++ + I A++ + + TPD+ G+ T V D I Sbjct: 282 NPMASILSIAMLFDYIGEKEK-----GDLIREAVKYCLINKKVTPDLGGDLKTKDVGDEI 336 Query: 356 CKIILR 361 I + Sbjct: 337 LNYIRK 342 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 185/359 (51%), Positives = 233/359 (64%), Gaps = 12/359 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M MR+A IPGDGIG +V E ++V+ +A G + + + ++ SCE Y+ G MMP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA---TGGRIEWTEFDY-SCERYAKTGAMMPP 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D L+ FDAI GAVG+P VPD +SLWG L+ RR F+QYVNLRPVRL PG+ PLA Sbjct: 57 DAPTTLAGFDAILLGAVGYP-GVPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASPLA 115 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 G + +VRENTEGEYS +GG N G ++E +QESVFTR G +RI+RYAFELA S Sbjct: 116 GVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAFELAAS 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 + SATKSNG+ SMPYWD +A YP+ H+D L AR V P DV+ Sbjct: 176 AGF-RVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPASLDVI 234 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 VASNLFGDILSDL A TG +G+A S N+NPERT S+FE VHGSAPDI G+ IANP+A Sbjct: 235 VASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIANPVAQ 294 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I AGAM+LD L N I A+++V++ G +TPD+ G ATT Q+ AI + Sbjct: 295 ILAGAMLLDHLNE-----PATANKIRLAVDQVLSDGRVRTPDLGGTATTEQLGTAIAEA 348 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 380 bits (976), Expect = e-104, Method: Composition-based stats. Identities = 125/359 (34%), Positives = 180/359 (50%), Gaps = 31/359 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+M+IA IPGDGIG EV+ + +L L F + A G +P++ Sbjct: 1 MKSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHAD-AGDACLKRTGTALPEE 55 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E + A FGA G S +++ RREFD + NLRPV+ PGVPC Sbjct: 56 TLEAVGEARATLFGAAG--------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLY-- 105 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D+DF +VRENTE Y EG + + + TR RI ++AF+ AQ Sbjct: 106 ---PDLDFVIVRENTEDLYVGDEEYTPEG-----AVAKRIITRTASRRISQFAFQYAQKE 157 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + +T+ K+N L + + + +A YP++ ++D + QP+ F +V Sbjct: 158 GMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEFQTIV 217 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NLFGDILSD G +G+APSAN+ + +LFEPVHGSAP I GKNIANP A I Sbjct: 218 TTNLFGDILSDEAAGLIGGLGLAPSANIGEK---NALFEPVHGSAPQIAGKNIANPTAMI 274 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +ML L +Q I A+++ +A G TPD+ G T ++A I + + Sbjct: 275 LTTTLMLKHLNK-----KQEAQKIEKALQKTLAEGLVTPDLGGKLGTMEMAAEIARHLE 328 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 124/369 (33%), Positives = 180/369 (48%), Gaps = 20/369 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 199 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + DA+ GA+G H+ LL+ R + NLRP + P + Sbjct: 200 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLG-GRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D VVRE T G Y G E+ V+ +DRI R AFE Sbjct: 260 TLKKEVAEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFE 319 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 AQ R R L S K+N L SM W +RV AMA YP++ ++D + V P++ Sbjct: 320 TAQKR-RGKLCSVDKANVLEASM-LWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQ 377 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FD +V +N+FGDILSD TG+IG+ PSA++ P LFEP+HGSAPDI G++ AN Sbjct: 378 FDTIVTNNIFGDILSDEASMITGSIGMLPSASVGES--GPGLFEPIHGSAPDIAGQDKAN 435 Query: 297 PIATIWAGAMMLDF-LGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGN--ATTPQV 351 P+AT+ + AM+L + LG G+ A I A+ + + G +T D+ G ++ Sbjct: 436 PLATVLSAAMLLRYGLGEGN-----AAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEM 490 Query: 352 ADAICKIIL 360 + + K + Sbjct: 491 GEQVLKAVE 499 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 378 bits (972), Expect = e-103, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 171/366 (46%), Gaps = 30/366 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + GDGIG E++ + VL+ AA L E +E Y ++ + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D Q+ R A+ G V P + R+ Y N+RP + P Sbjct: 57 DTWSQIFRTKALLKGPVTTPQ----GGGYKSLNVTLRKTLGLYANVRPSCSY----FPFV 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +ID ++REN E Y+ + + + +R G ++I+R+AFE A Sbjct: 109 NTSAPEIDVVIIRENEEDLYAGIEY----HHTADTYESVKLISRSGSEKIIRFAFEYALK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RKT++ +K N + + + + +A Y I+ D IDI AR + P++FDV+ Sbjct: 165 NNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSPQKFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDILSD+ +G+IG+A SAN+ + ++FE VHGSAPDI G+NIANP Sbjct: 225 VTSNLYGDILSDIAAKISGSIGLAGSANIGKDY---AMFEAVHGSAPDIAGQNIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADA 354 + A MML LG + I A+++ I G T D+ + T + A A Sbjct: 282 LNAAIMMLVHLG-----LTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQA 336 Query: 355 ICKIIL 360 I + Sbjct: 337 IINNLE 342 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 175/358 (48%), Gaps = 15/358 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T I A+PGDGIG E+L + +L+ + ++ F E E+ G+ + + Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGG-ASIDTFGEPLTEKTL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC--PLAG 121 R DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 NACKRADAILLGAIGGPKWTDPNNRPEQGLLKLRKSLNLFANIRPTTVVKGASSLSPLKA 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 ++ D +VRE T G Y N + +TR ++RI+ AF+LA SR Sbjct: 121 ERVEGTDLVIVRELTSGIYFGEPRYFNNHE----ALDSLTYTREEIERIVHVAFKLAASR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS K N LA S W + V +++ YPE+ + +D + P++FDV+V Sbjct: 177 -RGKLTSVDKENVLASS-KLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ + + P L+EP+HGSAPDI GKN+ANP I Sbjct: 235 YENLFGDILSDEASVIPGSLGLSPSASFSND--GPRLYEPIHGSAPDIAGKNVANPFGMI 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + AM L A + + I +I HG T D+ G T + + + + + Sbjct: 293 LSLAMCLR----ESLNQPDAADELEQHIYNMIEHGQTTADLGGKLNTTDIFEILSQKL 346 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 377 bits (969), Expect = e-103, Method: Composition-based stats. Identities = 133/356 (37%), Positives = 194/356 (54%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RI I GDGIG EV+P RVL+A G L F + E A E + G +P++ E Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA----TGLPLEFVEAE-AGWETFERRGTSVPEETVE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ A FGA P +G++ RR D Y N+RP + P Sbjct: 58 KILSCHATLFGAATSPTRKVPG--FFGAIRYLRRRLDLYANVRPAKSRP------VPGSR 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 +D +VRENTEG Y R +V I ++V +++ +RI R A +A+ RPRK Sbjct: 110 PGVDLVIVRENTEGLYVEQERRY-----LDVAIADAVISKKASERIGRAALRIAEGRPRK 164 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 TL A K+N L ++ + + V+ +A+++P + +D + VM+PERFDV+V +N Sbjct: 165 TLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDVIVTTN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GDILSDL G +G+APS N+ ++FEPVHGSAPDI GK IANP A I + Sbjct: 225 LLGDILSDLAAGLVGGLGLAPSGNIGD---TTAVFEPVHGSAPDIAGKGIANPTAAILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AMMLD+LG ++A + A++ V+ GP+TPD+ G+ATT +A+ + + Sbjct: 282 AMMLDYLGE-----KEAAKRVEKAVDLVLERGPRTPDLGGDATTEAFTEAVVEALK 332 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 113/375 (30%), Positives = 173/375 (46%), Gaps = 41/375 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ IPGDGIG EV VL+A G L + ++E A E +G +P E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVE-AGVEVIEKYGTPLPPQVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G +G P + R+E D Y NLRP + PG+ P Sbjct: 58 SIRETRVAIKGPIGT----PVGTGFRSVNVAIRKELDLYANLRPAKSLPGIKSPF----- 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTE----------------HEVVIQESVFTRRGVD 168 DID VVRENTE Y+ + I + G Sbjct: 109 QDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPISEFGSR 168 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 RI+++AFE A+ RK +T+ K+N + + + + +A+ YP+I ++ +D +C Sbjct: 169 RIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIVDNMCL 228 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 + + +P+ +DV+V +NL+GDI+SDL G +G+AP AN+ ++FE +HGSAP Sbjct: 229 QLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD---GIAVFEAIHGSAPK 285 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM--KGN 345 G+N NP A I +GAMML +LG + + + VIA G T D+ Sbjct: 286 YAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAV-----QSVIAEGKYVTYDLAQGEP 340 Query: 346 ATTPQVADAICKIIL 360 T ++A+AI + Sbjct: 341 VGTQEMAEAIAARVQ 355 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 376 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 110/359 (30%), Positives = 172/359 (47%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + I GDGIG E+ + AA + +E ++ +PDD Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAA----NAPIKWEPVDVTPI--LKDGKTAIPDDAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E + R G + P L RR F+ + N+RP R G P Sbjct: 108 ESVRRNYVALKGPLAT----PVGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY---- 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V +G VV + T+ +R+LR+AF+ A+S + Sbjct: 160 -DNVDTVLIRENTEGEYSGIEHVVVDG----VVQSIKLITKEASERVLRFAFQYARSINK 214 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 K + K+ + +S + +A+++P++ +D + +D C + V P ++ V+V Sbjct: 215 KKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYNDKVLV 274 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GDILSD+ G +G+ PS N+ E S+FE VHGSAPDI GK +ANP A + Sbjct: 275 MPNLYGDILSDMCAGLIGGLGLTPSGNIGDE---CSIFEAVHGSAPDIAGKGLANPTALL 331 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +G + I AI + +A G T D+ G A T + A+AI K + Sbjct: 332 LSSIMMLQHMG-----LHEHAGRIQKAIFDTLAEGKALTGDLGGKAKTSEYAEAIMKKL 385 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 107/356 (30%), Positives = 170/356 (47%), Gaps = 26/356 (7%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPGDGIG E+ +++ AA + +E+ + + M+P + E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQWEERNVTAIQGP-GGKWMIPSEAKES 87 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + + G + P L R+ FD Y N+RP G P Sbjct: 88 MDKNKMGLKGPLKTPIAA----GHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYT----- 138 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D++ +RENTEGEYS + + +G VV + T RI +AFE A++ R Sbjct: 139 DVNIVTIRENTEGEYSGIEHVIVDG----VVQSIKLITEGASKRIAEFAFEYARNNHRSN 194 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + +S + ++ +AE+ +I++++ ++D +C V P +FDV+V NL Sbjct: 195 VTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNL 254 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL G +G+ PS N+ ++FE VHG+APDI GK++ANP A + + Sbjct: 255 YGDILSDLCAGLIGGLGVTPSGNIGAN--GVAIFESVHGTAPDIAGKDMANPTALLLSAV 312 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 MML +G I AA I G T D+ GNA + IC+ + Sbjct: 313 MMLRHMG-----LFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVK 363 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 177/359 (49%), Positives = 224/359 (62%), Gaps = 12/359 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT RIA +PGDGIG++V VL+ A GF+L + W SC+YY +G MMP D Sbjct: 1 MKTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPW-SCDYYLENGSMMPAD 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAI GAVGWP VPD +SL G LL R+ F QY N+RP RL PGV PL Sbjct: 60 GIETLKSFDAILLGAVGWPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGPL-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + D +RENTEGEYS GGR+++G ++EV I+ ++FTR+GV+RILR+ FE A++R Sbjct: 118 -RSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQARAR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R L S TKSN SM +WDE ++ YP++ HID + AR VM PE DVV Sbjct: 177 -RGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLDVVA 235 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI IANPIA I Sbjct: 236 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPIAAI 295 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 W+GAMML+ LG A ++ AIE A G + G T + ++ + Sbjct: 296 WSGAMMLEHLGET-----AAAEKVMDAIETTTARGV--GAIPGKDRTDAITASVLSALG 347 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 164/352 (46%), Positives = 224/352 (63%), Gaps = 12/352 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M + +PGDG+G EV+ E + L A +++ + W +++ HG MMP D + Sbjct: 1 MNVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPW-GSAWWAEHGTMMPADAID 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L DAI GAVG P VPD +LWG +LK R+E D +VN+RP RL G+P PLAG+ P Sbjct: 56 VLRGHDAILMGAVGDP-AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPLAGRAP 114 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D+D VREN+EGEY+ +GGRV+ G H+V I+ SVFTRRG +R++RYAF +A +R + Sbjct: 115 HDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASAR-KG 173 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L +ATKSN P+WDE V + +P + D+ +D L AR + P DVVVASN Sbjct: 174 VLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVVASN 233 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDIL+D+ A G +G+A SANL+P P+LFEPVHGSAPDI G+ IANP+ IW+ Sbjct: 234 LFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAIWSA 293 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A+ML+ LG G + ++ A+E V GP+T D+ G ATT +V DA+ Sbjct: 294 ALMLEQLGAG-----EGSRRLMDALETVCRRGPRTRDVGGTATTAEVGDAVV 340 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 373 bits (958), Expect = e-102, Method: Composition-based stats. Identities = 144/359 (40%), Positives = 195/359 (54%), Gaps = 24/359 (6%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M KT +I I GDGIG EV+P VL+A G F + + A E + G +P+ Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA----TGLKFEFVEAQ-AGWETFERIGTSVPE 55 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E ++ DA FGA P +G++ RR+ D + N+RP + P Sbjct: 56 ATLEAVTHTDATLFGAATSPTKKVPG--FFGAIRYMRRKLDLFANVRPAKHHP------V 107 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +D VVRENTEG Y EG E+ I ++V TR+ RI YA LA S Sbjct: 108 PGSRPGVDLIVVRENTEGLYVEQERSYLEG---EIAIADTVITRKASARIGEYAARLAAS 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RPRK L A K+N L ++ + V A A +PE++ ID + V PERFDV+ Sbjct: 165 RPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPERFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V +NLFGDI+SDL G +GIA S N+ + ++FEPVHGSAPDI GK IANP AT Sbjct: 225 VTTNLFGDIISDLTAGLVGGLGIAASGNIGIKH---AVFEPVHGSAPDIAGKGIANPAAT 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 I +G MMLD LG +A + AA+++V+ GP+TPD+ GNATT Q A+A+ + + Sbjct: 282 ILSGVMMLDHLGE-----HEAARRVEAAVDKVLQEGPRTPDLGGNATTLQFAEAVARSL 335 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 117/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + IPGDGIG E++ R+++A G + +E + + +PDD E + Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 R + G + P + + R+ F+ + N+RPVR P VP P G + Sbjct: 79 KRTRVVLKGPLET----PVGYGEKSANVTLRKLFEAFANVRPVRELPSVPTPYRG---RN 131 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+++ R G V I + + +G ++I+R+AFELA++ RK + Sbjct: 132 IDLVVVRENIEDLYAAIEYRETPG----VTIAHKLISYKGSEKIIRFAFELARAEGRKKV 187 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 T ATKSN L ++ ++ E +A YP+I + ID + V PE+F+V+V +NL Sbjct: 188 TCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVIVTTNLN 247 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDI+SDL G +G A S N E ++FEPVHG+AP GKN+ NP A I M Sbjct: 248 GDIISDLASGLVGGLGFAASGNYGHE---VAIFEPVHGTAPKYAGKNVINPTAMILTAVM 304 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGN---ATTPQVADAICKIILR 361 ML ++ + I A+ + G T D+ G+ +T DAI + R Sbjct: 305 MLRYIDEFET-----AETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGR 358 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 372 bits (955), Expect = e-101, Method: Composition-based stats. Identities = 102/358 (28%), Positives = 165/358 (46%), Gaps = 27/358 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + ++ PG GIG E+ + AA + +E E + G ++ ++ Sbjct: 303 QNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEA-GDLIKEES 357 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G P + R++ + + N+RP R GV P + Sbjct: 358 LNAVINYKWGLKGPFATPI----GKGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPYS-- 411 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +RENTEGEYS L V G VV + ++ + I RYAFE A+ Sbjct: 412 ---NVDLVTIRENTEGEYSGLEHAVVPG----VVENLKIISQPACENIARYAFEFARKNN 464 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK + + K+ + + + ++ YPEI + ++ ID +C + PE FDV+V Sbjct: 465 RKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEVFDVMVM 524 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDI+SDL G +G+ S N++ +++E VHG+APDI G N ANP A + Sbjct: 525 PNLYGDIVSDLCAGLIGGLGLTASGNIS---HTCAVYEAVHGTAPDIAGLNKANPTALLL 581 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 +G MML +G Q+ I A+ + ++ G T D+ G ATT A+ I Sbjct: 582 SGVMMLKAMG-----LQKEGFAIEEAVIKTLSEGKFLTGDLGGKATTTDYTKAVIGHI 634 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 123/367 (33%), Positives = 175/367 (47%), Gaps = 21/367 (5%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA + GDGIG EV+ E +VL A ++ F ++ + + +HG +PD Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGG-AAIDNHGNALPDSTMAG 61 Query: 66 LSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL--- 119 DAI FG+VG P P +LL R FD + N+RP L P + Sbjct: 62 CIESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLR 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + D V+RE T Y E E ++RR V RI AF+ AQ Sbjct: 122 SDISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQ 181 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R +TS K+N LA S W + VE +A YP++ + ++D + V P +FDV Sbjct: 182 KRN-NKVTSVDKANVLATSQ-LWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 ++ NLFGDILSD+ TG++G+ PSA+LN + ++EP GSAPDI G +ANPIA Sbjct: 240 MLCPNLFGDILSDICAMITGSMGLLPSASLNSD--GFGMYEPAGGSAPDIAGLGVANPIA 297 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM------KGNATTPQVAD 353 I + A+ML + A I A+ + +G T D+ K +T +V D Sbjct: 298 QILSAALMLRY----SLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGD 353 Query: 354 AICKIIL 360 ICK I Sbjct: 354 YICKQIE 360 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 179/322 (55%), Positives = 212/322 (65%), Gaps = 6/322 (1%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MKT +A IPGDGIG +V + VL AAA + FA W SCEYY HG+MMP+D Sbjct: 1 MKTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPW-SCEYYLEHGRMMPED 58 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L FDAIY GAVGWP TVPD +SL G LL R+ F+QY N+RP RL GV PL Sbjct: 59 GIETLRGFDAIYLGAVGWPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGPLK- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +RENTEGEYS GGRV+EG +EV ++ SVFTR GV+RILR+ FE A+SR Sbjct: 118 --AEGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQARSR 175 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R LTS TKSN SM +WDE +A YP++ HID + A+ VM P+ DVVV Sbjct: 176 -RGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLDVVV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 ASNLFGDIL+DLG A G +G A SAN+NP+R+ PS+FEPVHGSAPDI GKNIANPIA I Sbjct: 235 ASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPIAAI 294 Query: 302 WAGAMMLDFLGNGDERFQQAHN 323 W+ A MLD LG + Sbjct: 295 WSVAQMLDHLGEAEVSAAVLSA 316 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 369 bits (947), Expect = e-101, Method: Composition-based stats. Identities = 159/356 (44%), Positives = 226/356 (63%), Gaps = 15/356 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +I IPGDGIG EV+ E ++ Q+ + + ++W ++Y GK++P D+ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSL----NLPIQRDYVDW-GIQHYLKTGKVVPIDYI 64 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 +Q+ ++DAI G++G P T+PD+++L L++ R++ DQ++ LRP + FPG+P PL Sbjct: 65 DQVKQYDAILLGSLGDPRTLPDYVTLE-PLIQMRQQLDQFLCLRPAKHFPGIPTPLKKC- 122 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 +ID VVREN+EGEYS++GG GT E I+ +V TRRG++R++RYAFE ++ R R Sbjct: 123 --EIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEASRKR-R 179 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T ATKSN + M WD EA+A YP++ +K ++D L A V P +FDV+V S Sbjct: 180 NHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDVIVGS 239 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NLF DI+SDL G++GIAPSAN+NPERTFPSLFEPVHGSA DI GK I +PI T+ A Sbjct: 240 NLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIGTMRA 299 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +MML+FLG +E I AI+ I T D+ G TT +V + I I Sbjct: 300 SSMMLEFLGYSEESV-----LIEEAIQSSILQKITTIDIGGTKTTNEVGNFIADYI 350 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 121/360 (33%), Positives = 181/360 (50%), Gaps = 19/360 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M++A +PGDGIG EV ++VL+A E G L++E + G+ P+ + Sbjct: 1 MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGG-AAIDAFGEPFPEPTRK 59 Query: 65 QLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLA 120 + +A+ G+VG P P I LL R+ D + NLRP ++FPG+ PL Sbjct: 60 GVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLK 119 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D +VRE T G Y G +++ V+R+ R AFE A+ Sbjct: 120 EEIARGVDVLIVRELTGGIYFGEP----RGMSEAEAWNTERYSKPEVERVARVAFEAARK 175 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R RK + S K+N L + +W + VE + YP++ + Q++D + V P RFDVV Sbjct: 176 R-RKHVVSVDKANVLEVGE-FWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVV 233 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V N+FGDILSDL G++G+ PSA+L +FEPVHGSAPDI GK IANP A Sbjct: 234 VTGNIFGDILSDLASVLPGSLGLLPSASLG---RGTPVFEPVHGSAPDIAGKGIANPTAA 290 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 I + AMML+ + + A+ + + P PD+ G+A T + + + Sbjct: 291 ILSAAMMLEHA----FGLVELARKVEDAVAKALLETP-PPDLGGSAGTEAFTATVLRHLA 345 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 368 bits (946), Expect = e-100, Method: Composition-based stats. Identities = 126/364 (34%), Positives = 187/364 (51%), Gaps = 18/364 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I IPGDGIGKE+ + VL+ E++G LS+ + A Y G +PDD Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKD-AGGTAYDKFGTPLPDDTI 60 Query: 64 EQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 E D + FGAVG V + ++L R+ Y NLRPV++ + PL Sbjct: 61 EACKASDGVLFGAVGGDKWDNVDPALRPEKAILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + +D +VRE G Y + E ++ VDRI + AFE A+ Sbjct: 121 KPELVKGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETAK 180 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R R +TS K+N LA S W V +AE+YP++ + ++D + ++P +FDV Sbjct: 181 LR-RGKVTSVDKANVLATSR-LWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDV 238 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V NLFGDILSD G+IG+ PSA++ T SL+EP+HGSAPDI GK IANP+ Sbjct: 239 IVTGNLFGDILSDEAAVVGGSIGMMPSASIG---TSTSLYEPIHGSAPDIAGKGIANPMG 295 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KG--NATTPQVADAI 355 TI + AM+L + + + + + A +A G +TPD+ +G A T ++ I Sbjct: 296 TILSAAMLLRYSLHEEAAAKAIEAAVDKA----LADGYRTPDLWKEGFQKANTEEITKVI 351 Query: 356 CKII 359 C+ I Sbjct: 352 CERI 355 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 125/366 (34%), Positives = 193/366 (52%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA +PGDGIG EV+ E ++VL+ ++ G + G+ +P++ + Sbjct: 1 MKIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGG-DAIDRFGEPLPEETKK 59 Query: 65 QLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPL 119 DAI+ G+VG P P+ G LL R+ + Y N+RP++++ + PL Sbjct: 60 ICLEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPL 119 Query: 120 AGKQPG-DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 K G +D VRE + G Y G + E ++ R+ V+RI R AFE+A Sbjct: 120 KEKVIGSGVDLVTVRELSYGVYYGQP----RGLDEEKGFDTMIYDRKTVERIARTAFEIA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R RK +TS K+N L SM W + V +A YP++ ++D + +++P +FD Sbjct: 176 KNR-RKKVTSVDKANVLYSSM-LWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ +N+FGDILSD A G++G+ PSA+ + L+EP GSAPDI GKNIANPI Sbjct: 234 VILTTNMFGDILSDESAALPGSLGLLPSASFGDKN----LYEPAGGSAPDIAGKNIANPI 289 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVADA 354 A I + AMML+ + I A+E VI G +T D+ + +T Q+ D Sbjct: 290 AQILSLAMMLEH----SFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDL 345 Query: 355 ICKIIL 360 ICK + Sbjct: 346 ICKKLE 351 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 116/359 (32%), Positives = 178/359 (49%), Gaps = 27/359 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I IPGDGIG E + ++VL+AA L++E E + + +P + E + Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + + G + P + + R+ F+ Y N+RPVR FP VP P AG Sbjct: 78 RKTRVVLKGPL----ETPVGYGEKSANVTLRKLFETYANVRPVREFPNVPTPYAG---RG 130 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTL 186 ID VVREN E Y+ + V + + +G ++I+R+AFELA++ RK + Sbjct: 131 IDLVVVRENVEDLYAGIEHMQTP----SVAQTLKLISWKGSEKIVRFAFELARAEGRKKV 186 Query: 187 TSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 ATKSN + ++ E +A+ YP+I +D + V +PE+F+V+V +N+ Sbjct: 187 HCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVIVTTNMN 246 Query: 247 GDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAM 306 GDILSDL G +G APSAN+ E ++FE VHGSAP GKN+ NP A + + M Sbjct: 247 GDILSDLTSGLIGGLGFAPSANIGNE---VAIFEAVHGSAPKYAGKNVINPTAVLLSAVM 303 Query: 307 MLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVADAICKIILR 361 ML +L + I A+ + G T D+ G A T + +AI + + + Sbjct: 304 MLRYLEEF-----ATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 160/355 (45%), Gaps = 13/355 (3%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RI + GDG+G EV+ VL +G + + G+ +P Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGV-AIDLTGQPLPQRTLAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 DA+ GAVG P LL R+ + N+RPV + K Sbjct: 63 CLASDAVLLGAVGGPRWDSAKERPEKGLLALRKGLGVFANVRPVTVESATAHLSPLKNAD 122 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +IDF VVRE T G Y S EV + R ++RI+ YAF+LA R +K Sbjct: 123 EIDFVVVRELTGGIYFSYPKERT----EEVATDTLTYHRHEIERIVSYAFQLANKR-KKK 177 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +TS K+N L S W E +A YP + + +D + P RFDV+V NL Sbjct: 178 VTSIDKANVLESS-KLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTENL 236 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSD G++G+ PSA+ PSL+EP+HGSAPDI GKN ANPIA + + A Sbjct: 237 FGDILSDEASVLAGSLGMLPSASHAE--KGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MML + I A+ V+ G T D+ G TT A+ + + Sbjct: 295 MML----GQSFGLTREGYAIEEAVSAVLKSGKCTADIGGTETTTSFTKAVIQEME 345 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 366 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 118/358 (32%), Positives = 182/358 (50%), Gaps = 23/358 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K R+A I GDG+G +V+ + VL A +++ + + A +G +P + Sbjct: 4 KKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPA-VAGLNTVEKYGTNLPKET 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L D + G P+ SL + + R+ FD Y ++RP + P VP Sbjct: 63 LDTLKETDCVLKGPTTTPE---GANSLPSANVGIRKYFDLYADVRPNKTLPNVPS----- 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++D +VRENTEG YS L RVN E I V TR+ +RI++YAF+LA+SR Sbjct: 115 IKPNVDMVIVRENTEGMYSGLDFRVN----QETTIGIRVITRKACERIVKYAFKLAESR- 169 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +K +T K N L +S + + A+ +P+++ D H+D + F+ QPE +DV+V Sbjct: 170 KKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFYDVIVT 229 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI+SD G IG SAN+ + ++FEP+HGS P G + NPI TI Sbjct: 230 ENLFGDIISDEAAMVVGGIGTGASANIGDKY---AMFEPIHGSVPKYTGMDKVNPIGTIM 286 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKII 359 + MMLD++ ++A I A+ +V+ G T D+ G A +V I + Sbjct: 287 SVKMMLDWMDY-----KEAGKAIEDAVYKVLEEGKILTYDLGGTAKCSEVGKEIASKV 339 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 365 bits (937), Expect = 1e-99, Method: Composition-based stats. Identities = 155/384 (40%), Positives = 219/384 (57%), Gaps = 32/384 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ I GDGIG EV+ EG +V+ AA E + F + + M + S ++Y G+ + + Sbjct: 1 MVSYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPF-SADHYVKTGETISES 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 ++LS++ AI+ G++G V + G LL R +DQYVNLRPV+L GV PL G Sbjct: 60 SLKELSKYRAIFLGSIGDDRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-----------------------HEVVIQ 158 K DIDFYVVRENTE Y +GGR +GT E+ Q Sbjct: 120 KTAADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEIAYQ 179 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 V ++ G RI+ Y+F+LA SRP+K L+S K+N L +W E A YP+++ Sbjct: 180 LGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPDVKT 239 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 D ++D + FV PE FDVVV+ N+FGDI++DLG G +G+AP N+NPE S+ Sbjct: 240 DFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPE--GTSM 297 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GP 337 FEP+ GSAP G N NPIATIWAGAM+L+ LG +QA GI+ AIE+ + Sbjct: 298 FEPMGGSAPKYKGLNKVNPIATIWAGAMLLEHLGE-----KQAAAGIVDAIEQNLKEKKI 352 Query: 338 KTPDMKGNATTPQVADAICKIILR 361 +T D+ G+A T V I +I+ + Sbjct: 353 RTYDLGGSAGTSDVGTDIARIVKQ 376 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 107/367 (29%), Positives = 170/367 (46%), Gaps = 30/367 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + I GDGIG E++ + +L+ A R + E +E Y H+ + + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E + R I + P + R+ + N+RP F P Sbjct: 57 QSWESIERTGVILKAPITTPQ----GGGYKSLNVTIRKTLQLFANIRPSVSFY----PFT 108 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 +++ ++REN E Y+ + R H + + +R G ++I+RYAFE A Sbjct: 109 KTLHPNLNLTIIRENEEDLYAGIEYRQT----HNMYESVKLISRTGCEKIIRYAFEYAVK 164 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 RK +T +K N + S + + +A+ YP+I + IDI AR +PE FDV+ Sbjct: 165 NNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKPEIFDVI 224 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 V SNL+GDI+SD+ +G++G+A SAN+ ++FE VHGSAPDI G++IANP Sbjct: 225 VTSNLYGDIISDVAAEISGSVGLAGSANIGEHY---AMFEAVHGSAPDIAGQDIANPSGL 281 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADA 354 + A MML +G GD I A ++ I G T D+ T + A+ Sbjct: 282 LNAAIMMLVHIGQGD-----IATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAEE 336 Query: 355 ICKIILR 361 + K + + Sbjct: 337 VVKRLGQ 343 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 122/363 (33%), Positives = 185/363 (50%), Gaps = 13/363 (3%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 T+ IA +PGDGIG+EV+P + ++ AA G Q A +YY+ G +P Sbjct: 7 TLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPASTL 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + + DAI FGA+GWPD + L R E + +RP+R FPG+P L + Sbjct: 67 DACRKSDAILFGAMGWPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRVLTDPR 126 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 IDF +VRE TEG + + G E E TR G R+ +AF++A+ R R Sbjct: 127 AEQIDFVLVREQTEGLFYARGR--GEIRNDEEAYDTMQITRSGTQRVTEFAFDIARQRKR 184 Query: 184 K----TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + +T K+N SM ++ + + +A+ + ++ D ++D L V +P FDV Sbjct: 185 RGKPGNVTCVDKANVF-QSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKPWTFDV 243 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+APSA++ + LF+P HG+APDI GK ANP A Sbjct: 244 LVTENMFGDILSDLAAGLIGGMGMAPSADIGDKH---GLFQPAHGTAPDIAGKGCANPSA 300 Query: 300 TIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAHGPKTP-DMKGNATTPQVADAIC 356 + AMMLD+L G A + A+E ++ P + GNA ++ ++ Sbjct: 301 MFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPMEYGGNANCAEMTRSVI 360 Query: 357 KII 359 + Sbjct: 361 SSL 363 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 364 bits (935), Expect = 2e-99, Method: Composition-based stats. Identities = 151/359 (42%), Positives = 208/359 (57%), Gaps = 11/359 (3%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K +R+A IPGDGIG EV+ + L+AA E G L +W E Y G MP D Sbjct: 6 KVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGG-ERYLRQGAAMPPDA 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + DA+ FGAVG PD VP+H +WG ++ R++ D VNLRPVR FPGVP + Sbjct: 65 ADLVKKTDAVLFGAVGRPD-VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKVRDT 123 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +D +VRENTEGEY GG + G+ H++ I+ +V +RR ++R AF LA R Sbjct: 124 --DGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFALAGRRS 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L TKSN + P WD V + E YP + + +D + AR + P DV++A Sbjct: 182 -GRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSLDVLLA 240 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 SNLFGDILSDL G +G+APSAN+ P+ P ++EPVHGSAPDI GK +ANP+A + Sbjct: 241 SNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANPVACLL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIIL 360 +GAM+L+ LG+ D A + A+ + + T D+ GNATT VA A+ + Sbjct: 301 SGAMLLEDLGHTD-----AARRVRDAVADTLRDTRHHTADLGGNATTADVASAVLHTME 354 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 364 bits (934), Expect = 3e-99, Method: Composition-based stats. Identities = 135/371 (36%), Positives = 188/371 (50%), Gaps = 29/371 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 I IPGDGIG+EV+P + VL+A G FE + A E + G+ +P Sbjct: 4 APYTILVIPGDGIGREVIPAAVAVLRA----TGLPFHFENAD-AGWECFQRQGEALPSAT 58 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI FGAV P +++ RRE D Y N+RPV F +P + Sbjct: 59 LTAARAADAILFGAVASPGYPVAG--YRSPIVRLRRELDLYANIRPV--FDDLPENGSNP 114 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR- 181 + +D VVRENTE Y+ ++G I E V TRR RI+R A +LA++R Sbjct: 115 RRRKVDLVVVRENTEDVYAGRERVEDDGAT---AIAERVITRRASARIMRVACDLARARR 171 Query: 182 --------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ 233 P +T K+N L + + +A+ YP+++ D+ +D + + Sbjct: 172 SARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQLATR 231 Query: 234 PERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 PERFDV+V +NLFGDILSD+ A G +G+APSANL +LFEPVHG+APDI GK Sbjct: 232 PERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGERH---ALFEPVHGAAPDIAGKG 288 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAH-----NGILAAIEEVIAHGPKTPDMKGNATT 348 IANP+A I A++LD L + I AI V A GP TPD+ G+A T Sbjct: 289 IANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDLGGSAVT 348 Query: 349 PQVADAICKII 359 + +A+ + Sbjct: 349 TDITNAVLSHM 359 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 364 bits (934), Expect = 3e-99, Method: Composition-based stats. Identities = 125/355 (35%), Positives = 186/355 (52%), Gaps = 29/355 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A I GDGIG+E++P ++VL A +G +E + G + ++ E Sbjct: 1 MRLAVIEGDGIGREIIPAAVKVLDA----FGLEFEKVPLEL-GYTRWERTGTAISNNDLE 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA+ FGA+ + LL R+E D Y N+RPV+ PG+ Sbjct: 56 TIKGCDAVLFGAITT----VPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGV---TGR 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D DF +VRENTEG YS + E+ + V TR+G +RI YA +LA+ R + Sbjct: 109 NDFDFIIVRENTEGLYSGIE-----EIGPELSWTKRVVTRKGSERIAEYACKLAKKR-KN 162 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT KSN L S + + A + ++ +D + +M+PER+D+VV +N Sbjct: 163 KLTIVHKSNVLK-SDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVTTN 220 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSD+ A G++G+ PSAN+ + + FEPVHGSAPDI GK IANP+A I Sbjct: 221 LFGDILSDMCAALVGSLGLVPSANIGEKY---AFFEPVHGSAPDIAGKGIANPLAAILCV 277 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L+++G I AI V+ TPD+ G A+T +V +A+ + + Sbjct: 278 KMLLEWMGEPR------SQIIDEAIAYVLQKKIITPDLGGTASTMEVGNAVAEYV 326 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 363 bits (933), Expect = 5e-99, Method: Composition-based stats. Identities = 106/366 (28%), Positives = 164/366 (44%), Gaps = 30/366 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK + I GDGIG E++ ++V+ A G L E++E Y + + Sbjct: 1 MKKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVYSMGNPSGIEPS 56 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E L R + P + R+ Y N+RP + P Sbjct: 57 SWESLKRTKVFLKAPITTPQ----GGGFKSLNVTVRKALGLYANIRPCISY----APFIH 108 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 + ID ++REN E Y + R + + TR+G +RI+RYAFE A+ Sbjct: 109 TKHPGIDLVIIRENEEDLYGGIEHRQ----GVDSFQALKIMTRQGTERIIRYAFEYARCY 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK ++S TK N L I+ + + E +A+ YP+I + IDI A+ P+ FDV+V Sbjct: 165 GRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQSFDVLV 224 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +NL+GDILSD+ G++G+ SAN+ E S+FE +HGSAP G+N+ANP + Sbjct: 225 LANLYGDILSDVAVQIAGSVGLGASANIGHEY---SMFEAIHGSAPRRAGQNVANPSGLL 281 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAI 355 A ML +G + + A + I G T D+ T + A + Sbjct: 282 LAAVQMLIHIGQ-----NAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREFARHV 336 Query: 356 CKIILR 361 K + + Sbjct: 337 IKNLGK 342 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 363 bits (932), Expect = 5e-99, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 178/367 (48%), Gaps = 18/367 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDGIG EV+ VLQ A G F++M G +P++ Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGG-AALDLVGVPLPEET 103 Query: 63 HEQLSRFDAIYFGAVGWPDTVP--DHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCP 118 DAI GA+G H+ +L RR+ + NLRP + P + Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDAST 163 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVN-EGTEHEVVIQESVFTRRGVDRILRYAFEL 177 L + +D +VRE T G Y + EV + ++ +DRI R AFE Sbjct: 164 LKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFET 223 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R R L S K+N L S+ W +RV A+A YP++ ++D + + P++F Sbjct: 224 ARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +N+FGDILSD TG+IG+ PSA+L P LFEP+HGSAPDI G++ ANP Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGES--GPGLFEPIHGSAPDIAGQDKANP 339 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATTPQVAD 353 +ATI + AM+L + ++A I A+ + + G +T D+ ++ + Sbjct: 340 LATILSAAMLLKY----GLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGE 395 Query: 354 AICKIIL 360 + K + Sbjct: 396 EVLKSVE 402 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 363 bits (931), Expect = 8e-99, Method: Composition-based stats. Identities = 102/364 (28%), Positives = 167/364 (45%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG E+ + +L AA G L E +E Y + +P + Sbjct: 20 TPIPVTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEA 75 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + ++R + G + P + R+ Y N+RP R + P+ Sbjct: 76 WDSIARTRVMLKGPITTPQ----GGGYKSLNVTMRKTLGLYANVRPCRTYK----PIVTT 127 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + D+D +VREN E Y+ + R +V + TR G +RI RYAFE A+ Sbjct: 128 RHPDMDVVIVRENEEDLYAGIEHRQT----QDVAQCLKLITRSGSERIARYAFEYARQHG 183 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T K N + ++ + + +A YPEI+ Q +D A FV +PE +DVV+ Sbjct: 184 RSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVVLL 243 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NL+GDILSD+ TG++G+ S N+ + ++FE +HGSAPD+ +++ANP + Sbjct: 244 PNLYGDILSDIAAQMTGSVGLGGSVNIG---SGGAIFEAIHGSAPDLA-RDVANPSGLLL 299 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG-----NATTPQVADAICK 357 A ML L + ++ A + G T D+ G A T + +A+ + Sbjct: 300 AAVEMLRHL-----KLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVIE 354 Query: 358 IILR 361 + R Sbjct: 355 RLGR 358 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 360 bits (923), Expect = 6e-98, Method: Composition-based stats. Identities = 106/350 (30%), Positives = 168/350 (48%), Gaps = 15/350 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +I A+PGDGIG E+L + +L+ +E++ F E + ++G + ++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVS-IDYYGTPLTNETL 60 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAG 121 + DAI GA+G P + LLK R+ + + N+RP + G PL Sbjct: 61 QSCKNADAILLGAIGGPKWTDPNNRPEHGLLKLRKSLNLFANIRPTFVTKGASHLSPLKQ 120 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 D +VRE T G Y V + + ++ + ++RI+R AF LA R Sbjct: 121 DIVEGTDLVIVRELTSGIYFGEPSYVKKTE----ALDSLKYSSQEIERIVRIAFNLANRR 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 RK LTS K N L S W + V + ++YPE+ + +D + QP +FDV+V Sbjct: 177 -RKKLTSVDKENVL-SSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVIV 234 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NLFGDILSD G++G++PSA+ +T L+EP+HGSAPDI ++ ANP + Sbjct: 235 TENLFGDILSDEASVIPGSLGLSPSASFG--QTGTRLYEPIHGSAPDIANEDKANPFGMV 292 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 + A+ L A N + + + I T D+ G T ++ Sbjct: 293 LSLALCLR----ESLNQNDAANELESIVYSFIQSNKTTADLGGQYRTSEI 338 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 164/358 (45%), Positives = 212/358 (59%), Gaps = 10/358 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T+++A IPGDGIG EV+ EG++VL A A R G L + E + + G+++PD Sbjct: 4 RTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYEL-GAQRWHATGEVLPDAV 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E+L + DAI GAVG P TVP + G LL+ R F YVNLRPVRL+PGV PLAG Sbjct: 63 EEELRQHDAILLGAVGDP-TVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGV 121 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 P DID VVRE TEG Y+ +GG + +GT HE+ Q+SV TR GV+R++RYAF A RP Sbjct: 122 APEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERP 181 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 LT K N L + W V + YP++ D H+D FV QP RFDVVV Sbjct: 182 CHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRRFDVVVT 241 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 NLFGDI++DLG A G IG+A S N+NPE FPS+FEPVHGSAPDI G+ A+P ATI Sbjct: 242 DNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKADPTATIL 301 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + ++ML+ LG D Q E G + +T Q+ D I + + Sbjct: 302 SVSLMLEHLGYADAAAQIDQAVAEDLQERAKNGGVR--------STTQIGDDIAQRVA 351 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 121/366 (33%), Positives = 195/366 (53%), Gaps = 22/366 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK I I GDGIG EV+ + I+ L + R+ S++ + A + G MP + Sbjct: 1 MKK-NIVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNV-LAGAKAIETFGDPMPKE 58 Query: 62 WHEQLSRFDAIYFGAVGWP--DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-PCP 118 + + DA+ FG++G P D+ P + LLK R+E D Y N+RP+ +PG+ P Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDGLLKLRKEMDLYCNIRPIVTYPGINKSP 118 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + ++ ++F + RE T G Y GR G E V++ + ++RI +F+ A Sbjct: 119 IKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSFKAA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +SR RK +T K+N L S W E ++ MA +Y ++ + +ID + ++ P +FD Sbjct: 176 RSRNRK-MTLVDKANVLETSR-LWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKFD 233 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ N+FGDILSD T ++G+ PSA++ ++ SLFEP+HGS P GKNIANP+ Sbjct: 234 VILTDNMFGDILSDEASILTSSLGLLPSASIGSKK---SLFEPIHGSYPQAKGKNIANPL 290 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 I + +MML++ Q N + A++ I TPD+ + +++T +V D Sbjct: 291 GCILSVSMMLEYF-----EMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDY 345 Query: 355 ICKIIL 360 I K I Sbjct: 346 IEKYIK 351 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 104/361 (28%), Positives = 170/361 (47%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDGIG E+ ++ AA + +E + + + + +PD Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAA----NVPIEWESCDVSPI--FVNGLTTIPDPAV 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + +++ G + P L R+ F + N+RP + G Sbjct: 90 QSITKNLVALKGPLATPI----GKGHRSLNLTLRKTFGLFANVRPAKSIEGFKTTY---- 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS + V G VV + TR +R++RYAFE A++ R Sbjct: 142 -ENVDLVLIRENTEGEYSGIEHIVCPG----VVQSIKLITRDASERVIRYAFEYARAIGR 196 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVV 241 + KS ++ + + +++ YP++ + + ID + V P + V V Sbjct: 197 PRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYTDAVSV 256 Query: 242 ASNLFGDILSDLGPAC-TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 NL+GDILSDL G++G+ PSAN+ + S+FE VHGSAPDI G++ ANP A Sbjct: 257 CPNLYGDILSDLNSGLSAGSLGLTPSANIGHK---ISIFEAVHGSAPDIAGQDKANPTAL 313 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP--KTPDMKGNATTPQVADAICKI 358 + + MML+ +G + I A+ IA GP +T D+ G ATT +A+ K Sbjct: 314 LLSSVMMLNHMG-----LTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTEAVIKR 368 Query: 359 I 359 + Sbjct: 369 L 369 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 357 bits (916), Expect = 4e-97, Method: Composition-based stats. Identities = 117/370 (31%), Positives = 180/370 (48%), Gaps = 19/370 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M IA +PGDGIG E + ++L +++ + + + + + G P Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGG-DAINSEGTPFPK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 + + +AI FGAVG P G+LL R+ F+ + NLRP+ L + Sbjct: 60 STLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKE 119 Query: 117 -CPLA-GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL P ID VRE T G Y + +E +V+ R ++RI A Sbjct: 120 LSPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LAQ R RK ++S K+N L SM W E V +A+NYP++ + +ID + + P Sbjct: 180 FKLAQKR-RKRVSSIDKANVLHTSM-LWREVVSHLAKNYPDVELEHLYIDNASMQLINNP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 +FD+++ NLFGDILSD +G+IG+ PSA++N L+EP GSAPDI KNI Sbjct: 238 SKFDIILCPNLFGDILSDECAMISGSIGMLPSASINEH--NFGLYEPAGGSAPDIAEKNI 295 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA----TTPQ 350 ANPIA I + A++ + + I A+ + + G +T D+ +T + Sbjct: 296 ANPIAHILSIALLFRY----SLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNE 351 Query: 351 VADAICKIIL 360 + D I +I Sbjct: 352 MGDIIAALIK 361 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 132/368 (35%), Positives = 195/368 (52%), Gaps = 29/368 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K++ I IPGDGIGKEV+P G +VL+ + G + +F +A + + GK +PD+ Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFID-LYAGFQTFQETGKALPDET 80 Query: 63 HEQLSR-FDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L FGAV P T + S ++ RRE + N+RPV+ G Sbjct: 81 VKVLKEQCQGALFGAVQSPTTKVEGYS--SPIVALRREMGLFANVRPVKSVEG------- 131 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ ID +VRENTE Y + +++ T V + RI A ++A Sbjct: 132 EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIALDIALK 191 Query: 181 R----PRKTLTSATKSNGLAISMPYWDERVEAMAE----NYPEIRWDKQHIDILCARFVM 232 R + TLT KSN L+ S + E + + E Y +I++++Q +D + R Sbjct: 192 RLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMVYRLFR 251 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 +P+ FDV+VA NL+GDILSD A G++G+ PSAN+ PE + EP HGSAPDI GK Sbjct: 252 EPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE---IVIGEPCHGSAPDIAGK 308 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQV 351 IANPIATI + A+ML+FLG+ +A I A++ + G KTPD+ G A+T QV Sbjct: 309 GIANPIATIRSTALMLEFLGH-----NEAAQDIYKAVDANLREGSIKTPDLGGKASTQQV 363 Query: 352 ADAICKII 359 D + + Sbjct: 364 VDDVLSRL 371 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 354 bits (909), Expect = 3e-96, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 170/366 (46%), Gaps = 15/366 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ + GDGIG E+ + VLQAA + + ++ E H + Sbjct: 1 MSNLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEI-GFASLKKHKTTFRSE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + D + G D P R+ FD Y N+RP + G Sbjct: 60 VLKIAEKCDGMILGTCSHNDYPPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLERF-- 117 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 P ID V+RENTEG YS G +V I TR+G RI F+ A Sbjct: 118 --PMGIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAEIGFKYA 175 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R RK L + K+N L S + E +++ YPE+ + +Q +D + A + P FD Sbjct: 176 MER-RKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRDPSVFD 234 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++A+NLFGD LSD G +G+A S N + + HGSAPDI GKNIANP+ Sbjct: 235 VILATNLFGDNLSDAASEIAGGLGLAESINAGENY---CIAQAQHGSAPDIAGKNIANPV 291 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAI 355 + I + AMMLD+LG +++ ++ I AI++ I + +T D+ GN +T D + Sbjct: 292 SLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDIGGNLSTTDFTDVL 351 Query: 356 CKIILR 361 + + Sbjct: 352 ISNLKK 357 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 353 bits (905), Expect = 8e-96, Method: Composition-based stats. Identities = 128/358 (35%), Positives = 182/358 (50%), Gaps = 31/358 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +IA IPGDGIGKEV+ I VL + A E HG +P + Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDELDVDFD-----YIYGIAGDECNEEHGTPLPQET 63 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + DA FGA G ++K R+E + NLRPV+ +P Sbjct: 64 IDIVRDSDACLFGAAGETAA--------DVIVKIRQEMKMFANLRPVKSYPNTKSLF--- 112 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ++DF +VRENTEG Y + E + I + V TR +RI+ YAF+ A+ Sbjct: 113 --ENVDFMIVRENTEGLYIAD----QEEETEDGAIAKRVITREAEERIIDYAFQYAKDNN 166 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T+ K+N L + + + + E YP+I + ++D V QP+ F VVV Sbjct: 167 RTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQVVVT 226 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIW 302 +NLFGDILSD G G +G+ PSAN+ + +LFEPVHGSAPDI G+ ANPIA + Sbjct: 227 TNLFGDILSDEGAGLVGGLGLIPSANIGADG---ALFEPVHGSAPDIAGQQKANPIAMML 283 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + MML +LG D A + AAI +V++ G T D+ G+ATT +VA A+ + Sbjct: 284 SAIMMLRYLGEND-----AADKFDAAILKVLSEGKTLTGDLGGSATTMEVAQAVKNAL 336 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 168/370 (45%), Gaps = 18/370 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMP 59 M +I +PGD +G+E+ E I+VL+A ++ R FE G +P Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGG-AAIDATGVPLP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 D+ E + DA+ GAVG P + LLK R+E Y NLRP Sbjct: 60 DEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDL 119 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P+ + DF VVRE G Y V +T V RI R A Sbjct: 120 SPIKPQFAKGTDFVVVRELVGGIYFGKRKE---DDGDGVAWDSEQYTVPEVQRITRMAAF 176 Query: 177 LAQSR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 +A P + S K+N LA S + E + +P ++ Q ID V P Sbjct: 177 MALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPT 236 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 + +++ SN+FGDI+SD G++G+ PSA+L + T L+EP HGSAPD+ Sbjct: 237 HLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDL-P 295 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQV 351 KN NPIATI + AMML + I A+++V+ G +T D+ G+ +T +V Sbjct: 296 KNKVNPIATILSAAMML----KLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEV 351 Query: 352 ADAICKIILR 361 DA+ + + + Sbjct: 352 GDAVAEEVKK 361 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 352 bits (903), Expect = 1e-95, Method: Composition-based stats. Identities = 114/370 (30%), Positives = 176/370 (47%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + ++ +PGDGIG E + E +V+ E+ C Y HG+ + D Sbjct: 1 MASRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAY-DAHGQAISDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E+ D++ FGAVG P VP + LL+ R++ Y NLRP +P + Sbjct: 60 DMEKALAADSVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDMQLYANLRPAICYPALAHSS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPEVIEGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA++R R +TS K N + + + E + +++ + D + V P++ Sbjct: 180 LARTR-RNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV++ NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + AAI V+ G +T D+ T Sbjct: 299 GIANPIAMIASLAMCLRY----SFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGT 354 Query: 349 PQVADAICKI 358 ++ DAI Sbjct: 355 TEMGDAILAK 364 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 350 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 166/360 (46%), Gaps = 30/360 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + IPGDGIG V +V++A + FE+ E +P++ Sbjct: 37 APRTVTLIPGDGIGPLVTGAVEQVMEAM----HAPVHFERYEVLGNMRK------VPEEV 86 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E + R G + P + ++ R+E D + +L PG+ Sbjct: 87 IESVKRNKVCLKGGLAT----PVGGGVSSLNMQLRKELDIFASLVNCINVPGLVT----- 137 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + ++D V+RENTEGEYS L V G VV V T+ +RI RYAFE A Sbjct: 138 RHENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITKFCSERIARYAFEYAYLNN 193 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T+ K+N + ++ + E +A++Y I +++ +D C + V +PE+FDV+V Sbjct: 194 RKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVT 253 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD-IYGKNIANPIATI 301 NL+G+++++ G G+ P N+ E D + + ANP+A + Sbjct: 254 PNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALL 313 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + AMML L RF + + A+++VI G +T D+ G+ TT +V DA+ + Sbjct: 314 LSSAMMLRHL-----RFPTFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 115/364 (31%), Positives = 186/364 (51%), Gaps = 12/364 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW-GFALSFEQMEWASCEYYSHHGKMMP 59 M ++ + + GDGIG EV + +R+L+ G ++ EY G+ +P Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEY-QRSGEALP 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 ++ DA+ GA+G P+ + L R Y +RP+RL+ PL Sbjct: 60 QSAYDACLASDAVLLGAMGLPNVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADTPL 119 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G PG+IDF +VRE+TEG + E + TR +R+ R AFE A+ Sbjct: 120 KGHGPGEIDFVLVRESTEGLFYGRD--AIADLEADEATNLLRITRSASERVCRLAFETAR 177 Query: 180 SR-PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 R +KT+T K+N L SM Y+ + +A+ + +I+ + ++D V +P+ FD Sbjct: 178 RRDGKKTVTLIDKANVL-SSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRPQDFD 236 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G +G+APS ++ + ++F+P HGSAPDI G++IANPI Sbjct: 237 VMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDD---AAVFQPSHGSAPDIAGQSIANPI 293 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICK 357 A + AMML++L + + R +V++ +T DM GN +T ++ D I + Sbjct: 294 AMHLSTAMMLEWLDHPETRRAADALNAAI--ADVLSDPTQRTADMGGNLSTVEITDKIAE 351 Query: 358 IILR 361 + + Sbjct: 352 RLSK 355 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 97/362 (26%), Positives = 161/362 (44%), Gaps = 33/362 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ GDG+G E++ + ++ A G + + +E Y + D E Sbjct: 3 KLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWET 58 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L R + + P + + R++ + N+RP + Q Sbjct: 59 LKRNKVLLKAPITTPR----GGGVRSLNVTLRKKLGLFANIRPCKS-------HLEWQDP 107 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +D ++REN E YS + R T + V T +RI RYAFE A+S RK Sbjct: 108 KMDIVIIRENEEDLYSGIEYRQTLDTYN----CTKVITESTSERICRYAFEYARSNGRKK 163 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T K N + ++ + + + +A YP+I + IDI AR PE+FDV+V NL Sbjct: 164 VTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFDVIVTLNL 223 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDI+SD+ +G++G+ S N+ E ++FE VHGSAPDI ++IANP + A Sbjct: 224 YGDIISDIAAEISGSVGLGGSINIGEEY---AMFEAVHGSAPDIADQDIANPSGLLNAAM 280 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKII 359 ML ++G ++ + +A + + G T D+ T + + I I Sbjct: 281 YMLSYIGQ-----KEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHNI 335 Query: 360 LR 361 R Sbjct: 336 DR 337 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 348 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 113/365 (30%), Positives = 173/365 (47%), Gaps = 14/365 (3%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K +A + GDGIG E++P +++L AA G +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + L D G + S R+ F + N+RP + F G Sbjct: 81 TLDALDEVDGWLLGPHDSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG-----GN 135 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELA 178 D +VRENTEG Y+ G +V I + TR +RI AF+LA Sbjct: 136 AIVEGTDLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAHEAFQLA 195 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 ++R K +T K+N L ++ + + + + YP++ + HID V + ++FD Sbjct: 196 RTRD-KRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVRRADKFD 254 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V+V N+FGDILSDL G++GIAPS N + ++ + HGSAPDI G++IANPI Sbjct: 255 VIVTENMFGDILSDLAGEVAGSLGIAPSINSSATH---AMAQASHGSAPDIAGRDIANPI 311 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAIC 356 A I + AM+L +L DE+ +A + + AA++ +A G TPDM G ++ ADA+ Sbjct: 312 AMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDMGGTSSCSGFADAVV 371 Query: 357 KIILR 361 R Sbjct: 372 AATAR 376 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 348 bits (892), Expect = 3e-94, Method: Composition-based stats. Identities = 117/381 (30%), Positives = 175/381 (45%), Gaps = 30/381 (7%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M T +I +PGD IG E++ E I+VL + HG + Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQ 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPV-RLFPGV--PC 117 + DA+ FG++G P+ H + LL+ R+ D + NLRP L P + Sbjct: 61 SVLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGAS 120 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 P+ F VVREN G Y E +V V+TR ++R+ R + + Sbjct: 121 PIREHVVKGTRFIVVRENCGGAYFGEKKE-----EEDVASDLWVYTRPEIERLARVSAAV 175 Query: 178 AQSRPRK-------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ R T+ SA K+N LA + + A+ +P+I Q D + Sbjct: 176 ARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSMAMLM 235 Query: 231 VMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGS 285 V P RF+ V+ N FGDILSD+ A TGT+G+ PSA+L ++EPVHGS Sbjct: 236 VRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGS 295 Query: 286 APDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG------PKT 339 APDI GK +ANP+A I + AMML + ++ + A+ +V+ +T Sbjct: 296 APDISGKGLANPVAQILSVAMMLRY----SMGLEKEATAVERAVVKVLDAKSEGGLEIRT 351 Query: 340 PDMKGNATTPQVADAICKIIL 360 D+ G AT QV DA+C+++ Sbjct: 352 GDLGGRATCSQVGDAVCEVLG 372 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 116/365 (31%), Positives = 180/365 (49%), Gaps = 28/365 (7%) Query: 1 MMKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMM 58 M +T +I IPGDGIG E++ + VL A G ++ ++A + G + Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL----GSPFEWDS-QYAGMAAIARVGDPL 61 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 P + + + G + P ++ R+EF+ + N+RP Sbjct: 62 PRETIQSIHHNKLALKGPLTT----PTGGGYRSVNVQLRKEFELFANVRPALTL------ 111 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE-HEVVIQESVFTRRGVDRILRYAFEL 177 + G + ++D ++REN +G Y++ + G + H V + TR G RI+RYAFE Sbjct: 112 IPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIRYAFEY 171 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPER 236 A RK +T K+N L + E + +A+ Y I ++++ +D + V+ P R Sbjct: 172 AMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLVLDPGR 231 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V +NLFGDILSDL G +G+AP N+ ++FE VHGSAPDI GK IAN Sbjct: 232 FDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIG---KQAAIFEAVHGSAPDIAGKGIAN 288 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE-EVIAHGPKTPDMKGNATTPQVADAI 355 P+A + A AMMLD +G D + AI + G +TPD+ G A T ++ A+ Sbjct: 289 PLALMLAAAMMLDHVGKTD-----LATRLRNAIRITTLEDGIRTPDLGGTAKTRELTQAL 343 Query: 356 CKIIL 360 I Sbjct: 344 ISRIG 348 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 347 bits (890), Expect = 5e-94, Method: Composition-based stats. Identities = 123/367 (33%), Positives = 186/367 (50%), Gaps = 30/367 (8%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER----WGFALSFEQMEW-ASCEYYSHHGKMMPDD 61 I IP DGIGKEV+P ++V+ AA + S + + A E + GK +P + Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKSLPVE 93 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L + D FG+V P + S ++ R+ D Y N+RP + Sbjct: 94 TVEALKNKCDGAIFGSVQSPSHKVEGYS--SPIVAMRKLVDLYANIRPCQDL-------- 143 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGG-RVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 ID +VRENTE Y V+ T + + + + T R RI A++LA Sbjct: 144 ---AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEIAYKLAV 200 Query: 180 SRPRK---TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 R + +T KSN L++S + E +++ YP+++ ++Q +D + + ++ P + Sbjct: 201 QRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKMILDPTQ 260 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 +DVVVA NL+GDILSD G A G +G+ SANL+ +L EPVHGSAPDI+GK I+N Sbjct: 261 YDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS---FALVEPVHGSAPDIFGKKISN 317 Query: 297 PIATIWAGAMMLDFLGNGDER---FQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVA 352 PIATI A AM+L L D + + + + A+ V+ TPD+ G T + Sbjct: 318 PIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGNTETLV 377 Query: 353 DAICKII 359 DAI K + Sbjct: 378 DAIIKNL 384 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 346 bits (888), Expect = 6e-94, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 66 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 67 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 119 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 120 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 175 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 176 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 235 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 236 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 292 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + I + I Sbjct: 293 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDIIRHIR 346 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 346 bits (887), Expect = 9e-94, Method: Composition-based stats. Identities = 112/372 (30%), Positives = 177/372 (47%), Gaps = 19/372 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T ++ +PGDGIG EV+ E R++ + + E Y + D Sbjct: 1 MATHKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGG-AAYDADKVAITDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 DA+ FGAVG P VP LL+ R++ + NLRP +P + Sbjct: 60 TMALAQASDAVIFGAVGGPKWDAVPYDARPEAGLLRLRKDLALFANLRPAVCYPALAEAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + + G + I V+ ++RI R AF+ Sbjct: 120 SLKPEVVEGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R R +TS K N + + + + + A Y +++ + Q D V P++ Sbjct: 180 LARKR-RNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +++EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN----ATT 348 +ANP+A + + M L + + + + AI V+A G +T D+K +T Sbjct: 299 GLANPVAMLASFGMALRY----SLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVST 354 Query: 349 PQVADAICKIIL 360 Q+ +AI + + Sbjct: 355 SQMGEAIVQEMQ 366 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 346 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 117/371 (31%), Positives = 168/371 (45%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E I+VL+A A F Q H + D Sbjct: 1 MATHNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 + DA+ GA+G P+ + LLK R+E Y NLRP Sbjct: 61 EALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + DF VVRE T G Y E ++R + RI R A Sbjct: 121 SPLKAEVCRGTDFIVVRELTGGIYFG---DRTEDDGSGYACDTEPYSRAEIVRIARLAGF 177 Query: 177 LA-QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA P + S K+N LA S + + +++ +P+++ + Q ID V P Sbjct: 178 LALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIY 290 + VV+ SNLFGDI+SD G+IG+ PSA+L + ++EP+HGSAPDI Sbjct: 238 ALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDIS 297 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK I NP+ TI + AMML + + + + AA++ I +G KT D+ GNATT Sbjct: 298 GKGIVNPVGTILSVAMMLRY----SLNLPKEADAVEAAVKAAIDNGTKTKDLGGNATTSD 353 Query: 351 VADAICKIILR 361 + +A+ + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 101/359 (28%), Positives = 155/359 (43%), Gaps = 30/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E++ V + A + FE++ +S + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHAC----VPVDFEEVHVSSNADEEDIRNAI----- 104 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + +P S R D Y N+ + PGV + Sbjct: 105 MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRTSLDLYANVIHCKSLPGVVT-----R 157 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID +VRENTEGEYSSL G VV + T+ RI YAF+LAQ R Sbjct: 158 HKDIDILIVRENTEGEYSSLEHESVAG----VVESLKIITKAKSLRIAEYAFKLAQESGR 213 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + +A YP+I ++ +D + V +P++FDV+V Sbjct: 214 KKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMP 273 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I++++ G G+ AN ++FE + I KNIANP AT+ Sbjct: 274 NLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AVFETATRNTGKSIANKNIANPTATLL 330 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A MMLD L + I A+ + TPD+ G TT + + + I Sbjct: 331 ASCMMLDHL-----KLHSYATSIRKAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIR 384 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 344 bits (882), Expect = 4e-93, Method: Composition-based stats. Identities = 108/371 (29%), Positives = 172/371 (46%), Gaps = 18/371 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 +K +I +PGDGIG EV+ E +V+ ++ + A Y HG + D+ Sbjct: 4 IKKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDE-DLAGGCSYDKHGTPITDE 62 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PC 117 + + + GAVG P +LLK R+E + NLRP F + Sbjct: 63 VFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDAS 122 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D +VRE T G Y + I +T + R+ + AF+ Sbjct: 123 TLKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFD 182 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R +TS KSN + + +E E + Y ++ D + + P++ Sbjct: 183 LARKRS-NRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQ 241 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V NLFGD+LSD TG++G+ PSA+L + +++EP+HGSAPDI GK Sbjct: 242 FDVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKE 301 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 IANPIA+I + AM L + + + A+++V+ G +T D+ K +T Sbjct: 302 IANPIASILSFAMALRY----SLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTS 357 Query: 350 QVADAICKIIL 360 + DAI + Sbjct: 358 AMGDAIISKLQ 368 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 102/359 (28%), Positives = 159/359 (44%), Gaps = 26/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG+E + + A + FE+++ E + + Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTA----NVPIEFEEIDVTGMEKNNKSSGDALHEAI 75 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P H S + R+E D Y +L ++ PG + Sbjct: 76 QSLKRNKVGLKGILFTPFEKGGHTSF---NVALRKELDIYASLVLIKNIPGFKT-----R 127 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++DF ++RENTEGEYS L + G VV + T RI ++AF+ A R Sbjct: 128 HDNVDFAIIRENTEGEYSGLEHQSVPG----VVESLKIITEYKSKRIAQFAFDFALQNGR 183 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K++T K+N + ++ + +A Y I +D + V +P++FDV+V Sbjct: 184 KSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFDVLVMP 243 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G ILS++G A G G+ P AN + +LFEP I G+ ANP A I Sbjct: 244 NLYGSILSNIGSALVGGPGVIPGANFGRDY---ALFEPGCRHVGLSITGRGEANPTAAIL 300 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 + +ML LG + + I AA VI G T D+ G+A+T AI + + Sbjct: 301 SACLMLRHLG-----LKDYADLINAATYSVIEEGKTLTKDLGGSASTGDFTHAILERME 354 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 343 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 148/362 (40%), Positives = 203/362 (56%), Gaps = 14/362 (3%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M +T+ +A +PGDGIG EV+ E +RVL+ A +L Q + ++ G+++ D Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVP-ADVSLDTTQYPF-GAGHFLETGQILTD 58 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVP---DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 L++ DAI GAVG I G LLK R FD Y+NLRP L PGV Sbjct: 59 SDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVAS 118 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 PLA PG +DF VVRE TEG Y+ GG + GTEHE+ + SV T GV+R +R+AFEL Sbjct: 119 PLAA--PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAFEL 176 Query: 178 AQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 A+ R RK +T K+N L + W V+ +A +P++ D H+D V P RF Sbjct: 177 AEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPSRF 236 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V+ NLFGDI++DL A +G IG+A S N+NP FPS+FEPVHGSAPDI G+ A+P Sbjct: 237 DVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKADP 296 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 A I + A++LD LG + + + T D +T +V DAI + Sbjct: 297 TAAILSVALLLDHLGLSEAAARVSAAVSDDLAARA------TGD-AAPRSTAEVGDAILR 349 Query: 358 II 359 + Sbjct: 350 AL 351 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 96/358 (26%), Positives = 167/358 (46%), Gaps = 25/358 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK-MMPDDWHE 64 + IPGDGIG E++ + + G + FE++ + + ++ Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFRHI----GVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + R G + P L+ R D + N+ + PG+ + Sbjct: 108 SIKRNGVAMKGNIFTPLDAIPG--FRSLNLELRVHLDLFANIVRCKSIPGIQT-----RH 160 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ++D ++R+NTEGEYS L G V+ V T +I +YAF+ A+ RK Sbjct: 161 NNVDLVIIRQNTEGEYSHLEHENVSG----VIENLKVTTEEACMKIAQYAFDFAEKHDRK 216 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K+N + + + E M+ +YP I ++ ID C + V P++FDV+V N Sbjct: 217 KVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVMVLPN 276 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIWA 303 L+G+I+S++G + G GI P N+ + ++FE + DI GK+I+NPI+ ++A Sbjct: 277 LYGNIVSNIGASLVGGPGIVPGENIGGDY---AIFESGSRHTGLDIQGKDISNPISMLFA 333 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 +ML+ L F + I +AI +V+ G T D+ G+ TT Q A+ + + Sbjct: 334 STLMLEHL-----EFTAYADLINSAILKVVQRGVLTADVGGSHTTTQFLSALKSELDQ 386 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 341 bits (875), Expect = 3e-92, Method: Composition-based stats. Identities = 109/370 (29%), Positives = 173/370 (46%), Gaps = 19/370 (5%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG E + E +++ E ++ C Y HG + + Sbjct: 1 MTARNLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAY-DAHGAAISEA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC-- 117 ++ DA+ FGAVG P VP + LL+ R++ + NLRP +P + Sbjct: 60 DMQKALAADAVLFGAVGGPKWDSVPYEVRPEAGLLRLRKDLQLFANLRPAICYPALASAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y + + G + I V+ ++RI AFE Sbjct: 120 SLKPELVEGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFE 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 +A++R + S K N + + + E Y +++ + D + V QP++ Sbjct: 180 MARTRQ-NRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGK 292 FDV+V NLFGD+LSD+ TG++G+ PSA+L +L+EPVHGSAPDI GK Sbjct: 239 FDVIVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGK 298 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATT 348 IANPIA I + AM L + + + + AI V+ G +T D+ T Sbjct: 299 GIANPIAMIASFAMCLRY----SFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGT 354 Query: 349 PQVADAICKI 358 ++ +AI Sbjct: 355 VEMGEAILAE 364 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 340 bits (873), Expect = 4e-92, Method: Composition-based stats. Identities = 126/350 (36%), Positives = 171/350 (48%), Gaps = 15/350 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + R+ +PGDGIG EV+ RV AAA R+G L +E+ G + Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRI-GAAAIREEGAPVSK 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CP 118 + + DA+ GAVG P+ + LL RRE + NLRPV P + P Sbjct: 60 ETLRRAGEADAVLLGAVGDPEFDGGEVRPEAGLLALRRELGTFANLRPVAAIPALSGSSP 119 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D +VRE T G Y E SV+TR V+R+ R AFE A Sbjct: 120 LRPGVAEGVDLLIVRELTGGAYFGEKEE-----GEERASDLSVYTRGEVERVARVAFEAA 174 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 + R R + S K+N LA S W V +A +YP++ + +D V P RFD Sbjct: 175 RGR-RGRVASVDKANVLATSR-LWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRFD 232 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V++ NLFGDILSD G++G+ PSA+L + P +FEPVHGSAPDI GK +ANP Sbjct: 233 VILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGS-PGIFEPVHGSAPDIAGKGVANPY 291 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATT 348 A I + AMM +A I +E +A G TPD+ G++ T Sbjct: 292 AAILSAAMMFRH----GLGRPEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 109/372 (29%), Positives = 177/372 (47%), Gaps = 18/372 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M ++ +PGDGIG EV+ + R++ + + Y HG P + Sbjct: 1 MAAKKLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGG-AAYDVHGTPYPAE 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV--PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 E DA+ GAVG P P LL R++ + NLRP + + Sbjct: 60 TLEAALAADAVLLGAVGGPKWDDLPFDKKPERGLLGIRKDMGLFANLRPATVLEALADAS 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFE 176 L + +D ++RE T G Y ++ V+T + RI R AF+ Sbjct: 120 TLKAEVVSGLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFD 179 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA+ R K L S K+N L ++ + +E ++ E +P++ ++D + V P++ Sbjct: 180 LARKRN-KKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQ 238 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP---ERTFPSLFEPVHGSAPDIYGKN 293 FDV+V N+FGDILSD TG++G+ PSA+L + +L+EPVHGSAPDI GK+ Sbjct: 239 FDVMVTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKD 298 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTP 349 +ANP+ATI + AM L + + I A++ V+ G +T D+ K +T Sbjct: 299 MANPLATIMSFAMCLRY----SFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTT 354 Query: 350 QVADAICKIILR 361 + +A+ + + + Sbjct: 355 VMGEAVVRELDK 366 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 121/364 (33%), Positives = 182/364 (50%), Gaps = 27/364 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + ++ +PGDGIG EV+ + +L+A AE G +++ Y H + P+D Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHI--------SLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + D I GAVGWP + +++ R + D Y N+RPV+L PGV Sbjct: 69 ARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGV 128 Query: 116 PCPLAG-----KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRI 170 ++G +P +D ++RENTEG Y+ +GG++ G V + TRRG +RI Sbjct: 129 AHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCERI 188 Query: 171 LRYAFELAQSRPR-------KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHI 223 +R AFEL + R R K +T K N L + E +A YP+I + + Sbjct: 189 IRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLE-GCKLFAEVFAEVASEYPDIANELAIV 247 Query: 224 DILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVH 283 D V QPE +DV V +NLFGDI++DL G +G+A N+ E ++FEP+H Sbjct: 248 DAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDEH---AMFEPIH 304 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTP 340 GSAP + GK+ ANP+A + A L +LG D R + + + A+ V G P T Sbjct: 305 GSAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTV 364 Query: 341 DMKG 344 D+ G Sbjct: 365 DLVG 368 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 177/366 (48%), Gaps = 25/366 (6%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IA + GDGIG E+ +G+ V+ A E++G +++E + G P++ + Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYE-YAICGADAIDKVGDPFPEETYR 61 Query: 65 QLSRFDAIYFGAVGWPDTVPD---HISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPL 119 DA+ F AVG P D + LL R++ + N+RPV+ F + PL Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPL 121 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 + DF +RE T G Y + +++ +++TR ++RIL+ FE A Sbjct: 122 RAELVEGADFLCIRELTGGMYFGEKYQ-----DNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RK LT K+N LA S W + + MA YPE+ D +D + + +P+ FDV Sbjct: 177 KR-RKHLTVVDKANVLASSR-LWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDV 234 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N FGDIL+D G +G++G+ PSA+ +FEP+HGS P G NIANP+A Sbjct: 235 MVTENTFGDILTDEGSVISGSMGLLPSASTGES---TPVFEPIHGSWPQAKGLNIANPLA 291 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADAI 355 I + AM+ ++ + I A++ + +TP++ T +V I Sbjct: 292 QILSVAMLFEYF-----DCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWI 346 Query: 356 CKIILR 361 I + Sbjct: 347 VDYIRK 352 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 339 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 103/363 (28%), Positives = 168/363 (46%), Gaps = 30/363 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ I GDG+G E++ + +L+ A +S E ++ +Y + Sbjct: 7 SVPITVAYGDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAPSAW 62 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E +SR + P + R+ YVN+RP + P+ G + Sbjct: 63 ESISRTRLLLKAPTMTPQ----GSGHKSLNVALRQRLGLYVNVRPCVSY----FPVVGTK 114 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 D+D ++REN E YS + +++E T V + TR ++I YAF A++ R Sbjct: 115 HPDLDVVIIRENEEDTYSGVEHKLSEDTHECV----KISTRSASEKICAYAFNYARAHNR 170 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T K N + ++ + +A+ YP+I + +D+ A+ PE FDVVV + Sbjct: 171 KKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVVVTT 230 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWA 303 NL+GDI+SD+ +G+IG+ SAN+ ++FE VHGSAPDI GKN+ANP + A Sbjct: 231 NLYGDIVSDIVSLSSGSIGLTGSANIGDYY---AMFEAVHGSAPDIAGKNVANPSGLLNA 287 Query: 304 GAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK------GNATTPQVADAICK 357 ML +G D+ I A + + G T D+ A+T + A AI Sbjct: 288 AVQMLVHIGQLDK-----AGVIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIVG 342 Query: 358 IIL 360 + Sbjct: 343 NLG 345 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 120/346 (34%), Positives = 177/346 (51%), Gaps = 9/346 (2%) Query: 17 KEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL-SRFDAIYFG 75 V+ E +L+ ER G + +++ + Y G P+ + A+ G Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDL-GADRYLRDGTTFPNQIQIAIQRECSAVLLG 77 Query: 76 AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVREN 135 A+G P VP+ L R +D Y N+RPVR PL G+ DIDF V REN Sbjct: 78 ALGDPR-VPNLEHARDILFGMRFGYDLYANVRPVRALSDRLVPLKGRTAKDIDFVVFREN 136 Query: 136 TEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGL 195 TEG Y +GG+ GT EV I E V TR+GV+RI+R AF+ A++ R +T A KSN + Sbjct: 137 TEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMADKSNAM 196 Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 + W + YPEI+ + ++D LC + P +F V+V +NLFGDI++DLG Sbjct: 197 RHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIVTDLGA 256 Query: 256 ACTGTIGIAPSANLNP-ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNG 314 A G +G+A SAN++ + +LFEPVHGSAP + GK+IANP A + ++L LG Sbjct: 257 ALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLAHLG-- 314 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + I + + + G T D+ G T + + I Sbjct: 315 ---WPEEERRIERWVSQALDQGMCTVDVGGTLGTRAAGAWVREQIA 357 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 97/359 (27%), Positives = 160/359 (44%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 +A + GDG+G E+L V Q G + FE++ D Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEV-----AVNQESEDATFTDAL 118 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + R + Y ++ R FPGV + Sbjct: 119 LAMKRNGVGIKGNFAT------EPGQSSRNVALRLNLNLYAFVQRCRNFPGVVT-----R 167 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RENTEGEYS L G VV + TR RI ++AF+ A R Sbjct: 168 HQNVDIVIIRENTEGEYSRLEHENVPG----VVESLKIITREKSTRIAQFAFDYAVRHNR 223 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + + + + ++A+NYP+I ++ ID C + V +P++FDV+V Sbjct: 224 KKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFDVIVLP 283 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ ++ G G+ NL P+ +LFE S + GKNIANP + Sbjct: 284 NLYGNIVGNVAAGLVGGAGLTTGINLGPQ---NALFEMGTRNSGRSLAGKNIANPCGMLL 340 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 A ML++LG+ + I ++ +VI +T D+ G+ T +V +A+ K + Sbjct: 341 TSADMLEYLGHI-----KEAKLIRDSVVDVIGEQKIRTADLGGSFKTSKVIEAVLKSLR 394 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 338 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 138/367 (37%), Positives = 190/367 (51%), Gaps = 19/367 (5%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 RIA +PGDGIG EV +RVL A F + F + A E + G P+ Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALG-TSFPIEFRDYD-AGAECFRRTGTAFPEATQV 70 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGS--LLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A+ GA G PD + + G +K R D Y N+RP+RL G P L GK Sbjct: 71 ACRQAHAVLHGAAGLPDVLFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ--- 179 P DI F +VRENTEG Y++ GG ++ V TR GV+RI+RYA ELA+ Sbjct: 131 GPDDIRFTIVRENTEGLYAARGG--GNIIRGQIATDTLVMTREGVERIVRYAAELARDGQ 188 Query: 180 ---SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 + + +T K+N L S ++ E + + + P I + +D + + +PE Sbjct: 189 GAPADGVRRVTIVDKANVLR-SYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERPEH 247 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+V NLFGDILSDLG A G +G+APS + + + F+ HGSAP I GK +AN Sbjct: 248 FDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRDHGY---FQGSHGSAPTIAGKGLAN 304 Query: 297 PIATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVAD 353 PIA I +GAMMLD+LG + D +A I A V+ G TPD+ G+ +T A Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCAA 364 Query: 354 AICKIIL 360 IC + Sbjct: 365 EICATLG 371 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 337 bits (865), Expect = 4e-91, Method: Composition-based stats. Identities = 109/382 (28%), Positives = 168/382 (43%), Gaps = 27/382 (7%) Query: 1 MMK-TMRIAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMM 58 M K T +I +PGDGIG EV+ E RVL+ A + E ++ C HG+ + Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCS-IDKHGEPL 59 Query: 59 PDDWHEQLSRFDAIYFGAVGWPDTVP-DHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 E DAI GA+G P + +LL R+ Y N+RP Sbjct: 60 TAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSLL 119 Query: 117 --CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 PL +D V+RE G Y + + + +++ V RI R Sbjct: 120 AYSPLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRSR 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 ++A P + S K+N LA S + E + +P+++ D +D V P Sbjct: 180 RQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVANP 239 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFP----------SLFEPVH 283 ++ + V++ NLFGDILSD G++G+ PSA+L +P ++EP+H Sbjct: 240 KKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPIH 299 Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEV-----IAHGPK 338 GSAPDI G+ IANPI TI + AM L ++ I AA+E G + Sbjct: 300 GSAPDIAGQGIANPIGTILSAAM----LCGTRSVWRSPAKAIEAAVEGARRQGDRREGLR 355 Query: 339 TPDMKGNATTPQVADAICKIIL 360 T D+ G++ T + + +I+ Sbjct: 356 TADLGGSSKTKDIGHKVVEILK 377 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 103/359 (28%), Positives = 166/359 (46%), Gaps = 34/359 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+ VL + G + FE ++ + D Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVLH----KCGAPIDFEVIDI--------KDESSTDAAI 134 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 L R G + + P + RR+ D Y N+ P + PGV + Sbjct: 135 ISLKRNGIGLKGTITTNISNPQS---QSINAQIRRKLDLYSNIVPCKSIPGV-----WTR 186 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G +D V+RENTEGEY SL +G VV + T + RI ++AF+ A R Sbjct: 187 HGQVDLVVIRENTEGEYGSLEHENVDG----VVESLKIITEKKSRRIAKFAFDYALQNNR 242 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 + +T+ K+N + ++ + E ++++Y +I ++ ID C + V P++FDV+V Sbjct: 243 RKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFDVMVMP 302 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+S +G G IG+ P N+ + ++FE D+ G N ANP ++ Sbjct: 303 NLYGNIVSHIGIGLVGGIGLVPGKNIGDKY---AIFESGARNIGSDLVGLNRANPCGFLF 359 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A+ML LG + I +A+ I +G +TPD++G+ TT DA+ K I Sbjct: 360 TSALMLRHLG-----LDDYADIIESAVRTTIKNGKCRTPDIQGDRTTADFIDAVIKEID 413 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 336 bits (861), Expect = 9e-91, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 175/366 (47%), Gaps = 16/366 (4%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA +PGDGIG E++ + VL+ ER G +Y G D+ Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAFSDENM 65 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + DA+ GA+G P + + L R E D Y LRP+R +P +P L K+ Sbjct: 66 AACKKADAVLLGAIGLPHVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVLVDKR 125 Query: 124 PGDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID +VRE TEG YS G + + V + + +R G R+ +AF +A+ R Sbjct: 126 ASQIDLVLVREQTEGILYSRCRGTIE---DDRVAWETMMISRNGTSRVSEFAFRVAERRA 182 Query: 183 R-----KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + + +SN L SM ++ +AE +P + D ++D + V P F Sbjct: 183 KSRRRPGKVLCVDRSNAL-TSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKSPWEF 241 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 DV+V N FG ILSDL G++G+APSA++ + ++F+P HGSAP I G+ +ANP Sbjct: 242 DVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEKH---AVFQPAHGSAPHIAGQGLANP 298 Query: 298 IATIWAGAMMLDFLG--NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 +A I + A+MLD+L +G+ R + A+E+ + + G T + AI Sbjct: 299 VAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALTV-VCPVEFGGKDGTAAITKAI 357 Query: 356 CKIILR 361 I + Sbjct: 358 IAQIRK 363 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 334 bits (856), Expect = 4e-90, Method: Composition-based stats. Identities = 98/359 (27%), Positives = 159/359 (44%), Gaps = 32/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDG+GKE+ + +A + +E + ++ + Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINIKQTDHKEGV-----YEAV 78 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E L R G P D + R++ D Y N+ + GV + Sbjct: 79 ESLKRNKIGLKGLWHTPA---DQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRI---- 131 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID V+RENTEGE+S L G VV V TR +RI R+AF+ A+ R Sbjct: 132 -PDIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRPKTERIARFAFDFAKKYNR 186 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K++T+ K+N + + + + + + YP+I +D + V +P +FDV+V Sbjct: 187 KSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVT 246 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATI 301 +++G IL ++G A G G+ AN + ++FEP DI G+N+ANP A I Sbjct: 247 PSMYGTILGNIGAALIGGPGLVAGANFGRDY---AVFEPGSRHVGLDIKGQNVANPTAMI 303 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TPDMKGNATTPQVADAICKII 359 + +ML+ LG + I A+ E IA G T D+ G+++T + I + Sbjct: 304 LSSTLMLNHLG-----LNEYATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 333 bits (854), Expect = 7e-90, Method: Composition-based stats. Identities = 114/374 (30%), Positives = 175/374 (46%), Gaps = 20/374 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + +I + GDGIG EV+ + RV+ + A E Y G + D Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGG-AAYDAQGTPLHD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDTV---PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP- 116 D DA+ GAVG P P + LL+ R++ + + NLRP +F + Sbjct: 60 DTVALALAADAVLLGAVGGPKWDASLPFELKPERGLLRLRKDLELFANLRPAMVFDALAE 119 Query: 117 -CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYA 174 L + +D +VRE T G Y ++ + V+ + R+ + A Sbjct: 120 ASTLKTELVSGLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKVA 179 Query: 175 FELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQP 234 F+LA R K L S K+N + S W E V + +YPEI + D + V QP Sbjct: 180 FDLAGKRG-KRLCSVEKANVME-SGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQP 237 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN---PERTFPSLFEPVHGSAPDIYG 291 ++FDV+V NLFGDILSD TG++G+ PSA+L +++EPVHGSAPDI G Sbjct: 238 KQFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAG 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM---KGNA-T 347 ++ ANP+ATI + +MML + + + + A+ V+A G +T D+ Sbjct: 298 QDKANPLATILSFSMMLRY----SFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVG 353 Query: 348 TPQVADAICKIILR 361 T + DA+ + + Sbjct: 354 TTGMGDALLAEMAQ 367 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 332 bits (851), Expect = 1e-89, Method: Composition-based stats. Identities = 112/356 (31%), Positives = 171/356 (48%), Gaps = 26/356 (7%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRIA I GDG+G E++ + +L+ F +++ A Y+ GK + D+ E Sbjct: 1 MRIAVIKGDGVGPEIMGATLSLLE-----RYIGADFIEIK-AGKSYFIEEGKPIEDNAIE 54 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D++ G V P P S RREF Y N+RP R + G+ Sbjct: 55 KIRECDSLLKGPVATPTKGP---SYPSVNTLLRREFKLYANVRPFRSYEGIS-------I 104 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID +VREN E Y + + I V T+RG +RI +AF LA+ R Sbjct: 105 RRIDTILVRENLECLYYGWEVE-----DEDRAIAMRVITKRGAERISEFAFNLAKREGRG 159 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T+ K N L + + + +A + ++R D + +D + V FDV++ N Sbjct: 160 RVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVMLTPN 218 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L+GDILSD+ G+IG+ SA + + + FEP+HG+ DI GK +ANPI I A Sbjct: 219 LYGDILSDVAAGVVGSIGLCGSAQIGED---FAAFEPIHGTGEDIAGKGVANPIGMIIAA 275 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 +MMLD+L R + I A++ VI TPD+ G+ T QV + I + Sbjct: 276 SMMLDWLWERG-RSPKRGEKIREAVDSVIRDRILTPDLGGDFRTEQVVEKIVDRLR 330 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 126/356 (35%), Positives = 173/356 (48%), Gaps = 15/356 (4%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 IA IPGDGIG EV+ + VL A G + ++ + + Y G+ + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDAL----GLGTRTDILDHVNADTYLRTGEALTGSDLDR 76 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + +A GAVG P + D + G L R E D YVN RP RL+ PL Sbjct: 77 IRSSEAALLGAVGDPR-LGDTSYVRGVLTTLRLELDLYVNYRPARLWHDRLSPLRDPARR 135 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 ID +VRENTEG YS +GG GT E+ + + TR GV R+L +AF A R++ Sbjct: 136 AIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA----RRS 191 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N + W +P I ++D R P FDV+V +N Sbjct: 192 VCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIVTNNS 251 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +GDILSDL A G +G+A SANLNP T +LFEPVHGSAPDI G ANP I + A Sbjct: 252 YGDILSDLTAALAGGLGVAASANLNP-VTGRALFEPVHGSAPDIAGSGTANPFGAILSVA 310 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIILR 361 ++ + LG +E +A G TPD+ G T +V A+ + R Sbjct: 311 LLAEHLGRNEEADAVRRAV-----AAAVAAGRVTPDLGGPLGTKEVGAAVLAELRR 361 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 173/355 (48%), Gaps = 31/355 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 RIA IPGDG+G E++ I VL+ ++ L E A E G +P++ Sbjct: 3 RIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFE-AGDETKRKRGVALPEETLNG 61 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + DA A+G S +L R++ D YVNLRP + +P + Sbjct: 62 VMNSDATLMVAIG--------ESAREVILPLRQKLDLYVNLRPAKSYP------VPRAIP 107 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 D +VRENTE Y G R + + + TRR +RI R+ + A+ R + Sbjct: 108 GFDLTIVRENTEDLYVMSGWR-----GLDTAVDLRIITRRASERICRFGYRYARERGKSR 162 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 + K+N L M + E +AE + + ++D R M FDV++ +N+ Sbjct: 163 VYVVHKANVLGGCM-LFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVIITTNM 219 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 FGDILSDL A G +G+ PSAN+ R ++FEPVHG+AP+I GKNIANP+ATI + A Sbjct: 220 FGDILSDLAAAFIGGLGMYPSANIGESR---AIFEPVHGTAPEIAGKNIANPMATILSAA 276 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 MM+ +LG+ I A+ G TPD+ G+ T +V I +I+ Sbjct: 277 MMMGWLGHEGG-----SKLIEEAVRRACELGYTTPDVGGSMRTKEVGLKISEIMR 326 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 119/361 (32%), Positives = 174/361 (48%), Gaps = 17/361 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I + GD IG E++PE +RV+QAAA R G A+ ++ + G +PD E Sbjct: 1 MKIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPI-GRAALDSLGSTLPDGTIE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L D G +G P R+ FD + N+RPV+ +PC Sbjct: 60 RLDALDGWLLGPIGH-MAYPKIPEAINPHPLLRKHFDLFANIRPVKSHAALPCL-----H 113 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D +VREN EG G +V I V TR G ++ R AFELA++R Sbjct: 114 QGVDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFELARAR 173 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R+ LT+ K + + E +A YP++ +D+ +D R VM P+R+DVVV Sbjct: 174 -RRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYDVVV 232 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDIL+D G +G+A P ++ + HGSAPDI G+ IANP A I Sbjct: 233 TTNMFGDILTDEAAGLVGGLGMAAGLCAGPRH---AMAQATHGSAPDIAGRGIANPYAMI 289 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKI 358 +G M+LD+LG A I A+ +I TPD+ G TT + AI + Sbjct: 290 MSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQGTTAGMGSAIIEA 349 Query: 359 I 359 + Sbjct: 350 M 350 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 329 bits (845), Expect = 6e-89, Method: Composition-based stats. Identities = 108/381 (28%), Positives = 163/381 (42%), Gaps = 36/381 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+T + +PGDG G E++ VL AA GF + ++ + A + ++PD Sbjct: 1 MRTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWD-VHQAGQRALAESESLLPDA 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + A G P + R+E D Y LRPVR P + Sbjct: 60 TLNSIRTNGAALKGPTTTPI----GTGHRSVNITIRQELDLYACLRPVRSLP-IASTQEE 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLG---------------GRVNEGTEHEVVIQESVFTRRG 166 + +D VVRENTE Y+ L G + + + FT G Sbjct: 115 PERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPFTPHG 174 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +R++ +AF A RK + S + + + +A +P I + L Sbjct: 175 CERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVPVPAL 234 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 CA V P R DV+V NL+GDI+SD+ A G++G+AP AN+ ++FE HGSA Sbjct: 235 CADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAHH---AVFEATHGSA 291 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDM--- 342 P+ G NP A I++G M+LD LG + I AA+E+V+A G T D+ Sbjct: 292 PEFAGSGRLNPTALIFSGCMLLDHLGE-----HETAARIRAAVEDVVAAGEVLTFDLLAP 346 Query: 343 ---KGNATTPQVADAICKIIL 360 ATT + A+ + Sbjct: 347 QRSADAATTVEFTRAVTDRLG 367 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 329 bits (843), Expect = 1e-88, Method: Composition-based stats. Identities = 113/366 (30%), Positives = 165/366 (45%), Gaps = 31/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI + G+GIG E+ IRV++A G ++ + A E +G +P + Sbjct: 1 MRIGVLKGNGIGPEITAATIRVIEA----TGIQPEWDFIPIA-DEAVRLYGHALPPQVIQ 55 Query: 65 QLSRFDAIYF---------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 ++ G + T ++ RRE + +VN RP+R + G+ Sbjct: 56 RIKDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGI 115 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +D ++RE TE Y + +G TR ++ +YAF Sbjct: 116 SG-----RHEKMDMVIMREITEDTYIGWEKPLEDGA---AAEAIKRVTRSASWKVSQYAF 167 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 E A+ RK ++ K+N L + + + +A YP+I D ID C V P Sbjct: 168 EYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPC 227 Query: 236 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 FDVVV N +GDI SDL G++G+AP AN+ S FE HG+APDI G A Sbjct: 228 WFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDS---ASTFEAAHGAAPDIAGTGAA 284 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADA 354 NPIA I +GA +L G G + I A+ VI G TPD+ G +TT QVADA Sbjct: 285 NPIALILSGAELLAHAGYG-----KGSEAIREAVTRVIEAGRTLTPDLGGRSTTEQVADA 339 Query: 355 ICKIIL 360 I + Sbjct: 340 ISVEVR 345 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 108/362 (29%), Positives = 175/362 (48%), Gaps = 13/362 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MRI +P DGIG E++ + VL++A + L+F+ + +G + D+ Sbjct: 1 MRILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDV-GFTSLEKYGTTLRDEVLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + +D + G D FR D Y N+RP R P + + + Sbjct: 60 KAKTYDGVILGTQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNMREGRT 119 Query: 125 GDIDFYVVRENTEGEY---SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 +D ++RE TEG Y + G ++ I TR +RI R AFELA R Sbjct: 120 --MDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFELAMKR 177 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 +K +T+ K+N ++ + E V +A ++PE+R D ID A V PERFDV+V Sbjct: 178 -KKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 A+N +GDI+SDL +G++G+A S + + HGSAPDI G++ ANP++ I Sbjct: 237 ATNFYGDIISDLASELSGSLGLAGSMMASDTH---CCAQAQHGSAPDIAGQDKANPVSMI 293 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + AM++ ++G + A + AA++ V+ + +TPD+ GN + K+ Sbjct: 294 LSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCGCKAFGQLVAKV 353 Query: 359 IL 360 I Sbjct: 354 IQ 355 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 106/369 (28%), Positives = 165/369 (44%), Gaps = 34/369 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + GDGIG+E++ ++A G + +EQM+ E + G + D Sbjct: 32 QAHTVLTFDGDGIGREIVSAAKECIEA----TGVNIRWEQMD-MGYEAMQNTGVYIDDSH 86 Query: 63 HEQLSRFDAIYFGAVGWPDTV------PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 + ++ G + P FR+ F + N+RPVR PGV Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 P D+D V+RENTE Y+ V+ T H V +R +R+ ++F+ Sbjct: 147 APF-----NDVDLVVIRENTEDVYTGEETWVDADTVHCV----KRISRGASERVADFSFK 197 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEA--MAENYPEIRWDKQHIDILCARFVMQP 234 A+ RK +T+ K+N S + A + I D Q D + +++P Sbjct: 198 YARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLMIEP 257 Query: 235 ERFDVVVASNLFGDILSDLGP----ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY 290 + FDV+ NL+GD+++ L G++G+ PS N+ T +LFEP HGSAPDI Sbjct: 258 KSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG---THQALFEPAHGSAPDIA 314 Query: 291 GKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 GK IANP + I +G MML LG +A + A+ + A G D G A T + Sbjct: 315 GKGIANPTSQILSGCMMLSHLGEF-----EASQRLENALRAMYASGIVPVDFGGQADTKE 369 Query: 351 VADAICKII 359 V A+ K + Sbjct: 370 VVAAVLKHL 378 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 95/360 (26%), Positives = 160/360 (44%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PGDGIG E+L ++ A + FE+ + S D+ Sbjct: 44 RHTVTLLPGDGIGPEMLDIVQKIFTFA----NVPVDFEECQLDSKPTSPESDL---DNAI 96 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + D ++ RR D + N+ P +P + Sbjct: 97 MSIQRNGVAIKGNIET---KYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPT-----R 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 I+ ++RENTEGEYS G VV + TR ++RI R+AF+ A + R Sbjct: 149 HKGINIVMIRENTEGEYSGHEHETVNG----VVESLKICTREKLERISRFAFDYAIAHNR 204 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMA-ENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 K +T+ K+N ++ + + V +A + YP I +D +D + V +P++FD+++ Sbjct: 205 KKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQFDIMLM 264 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATI 301 NL+G+I+S++ G G+ N+ + ++FE + I G++IANP A I Sbjct: 265 PNLYGNIISNIACGLVGGPGLVSGMNIGDKY---AVFETGTRNTGSGIAGQDIANPTAFI 321 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 AG ML +LG + N I A+ + I T D+ G A T V +A+ + I Sbjct: 322 RAGVDMLHYLG-----LTEYANLISDALFDAIVIKRLHTKDIGGTAKTSDVVNAVMRNIE 376 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 326 bits (836), Expect = 8e-88, Method: Composition-based stats. Identities = 97/357 (27%), Positives = 159/357 (44%), Gaps = 36/357 (10%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 + IPG GIG E+ V +A + F+ ++ + E DD Q Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL----HVPIKFDVLDNFNFEN---------DDSKSQ 80 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 L + + I G + + KF + D Y N+ G+ ++ Sbjct: 81 LRKNECILLGVMTEKNQKYTD------NYKFYKYLDLYSNITFAFSVEGIT-----QRHN 129 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 + D V+RENTEGEYS + V G VV V T++ RI YAFE A R+ Sbjct: 130 NTDIVVIRENTEGEYSGVEHEVYPG----VVESIKVTTKQASLRIAEYAFEFAHLSGRRK 185 Query: 186 LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNL 245 +T+ K+N + + + + +A+ Y I++++ ID C + V P +FDV+V NL Sbjct: 186 VTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVMVMPNL 245 Query: 246 FGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGA 305 +G I+ ++ TG +G+A A++ + S + + DI GKN+ NP A + + Sbjct: 246 YGSIVQNVVAGITGGVGMAAGASIGKDHALFS--QGCRHTGRDIAGKNVVNPSAMLVSST 303 Query: 306 MMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKIILR 361 ++L LG + I A++ I KT D+ GNATT Q + + + R Sbjct: 304 LLLRHLG-----LPNFADQICRAVQHTIQDKKIKTKDIGGNATTDQFTSEVIRSLGR 355 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 108/406 (26%), Positives = 168/406 (41%), Gaps = 66/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM--MPDDWHE 64 I I GDGIGK+V P +VL+AAAE G +S+ ++ +A +G+ +PD+ + Sbjct: 33 IPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRV-YAGESAREEYGEDVNLPDETVD 91 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + G + P + R+ D Y N+RP GVP P+ P Sbjct: 92 AIREHRVAIKGPLTT----PVGAGFRSLNVALRQTLDLYANVRPTYYLDGVPSPMKA--P 145 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTRR 165 ++D RENTE Y+ + +V I T + Sbjct: 146 EEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPIGIGLKPITEK 205 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE--------- 215 G R++R A + A R +T K N + + + + +A E YP+ Sbjct: 206 GSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYPDDEVFAAPDS 265 Query: 216 --------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTI 261 + +++ D + ++ + FD++ NL GD LSD A G + Sbjct: 266 LWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLSDAAGAQIGGL 325 Query: 262 GIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQA 321 GIAP N L EPVHGSAP G+++ANP A I +G +M D+LG + A Sbjct: 326 GIAPGGNFG---KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDYLG-----WDDA 377 Query: 322 HNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + I A+EE I+ G T D++ T + D I I + Sbjct: 378 ADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 95/361 (26%), Positives = 161/361 (44%), Gaps = 32/361 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP-DDW 62 + +PG GIG E++ R ++A + FE + ++ G D Sbjct: 47 RFFVTLLPGHGIGPEMM----RHVEAIFACGKVPVDFETIIV-----DANVGDASSMDHA 97 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + R G + +++ L R + + YVN+ R PG+ Sbjct: 98 IKSIRRNGVALKGNIETTSY---SMTVEPRNLLLRNKLELYVNVVHCRNHPGI-----NT 149 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 + +D V+R+NTEGEYS L V G VV + T +I +Y FE A++ Sbjct: 150 KHKGVDIVVIRQNTEGEYSCLEHEVTSG----VVESLKIITWAKSFQIAKYCFEYARTHM 205 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 RK +T K+N + ++ + + +A+ YP+I + ID C + V P +FDV++ Sbjct: 206 RKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDVMLV 265 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATI 301 NL+G+I+ ++ G G+ N E ++FE + + GKN+ANP+AT+ Sbjct: 266 PNLYGNIVVNVACGLVGGAGVTSGRNYGKEY---AVFETATRNTGTPLVGKNLANPVATL 322 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVI-AHGPKTPDMKGNATTPQVADAICKIIL 360 +A ML L I AIE+ + T D+ G+ATT +V + I K + Sbjct: 323 YAAVDMLKHL-----ELWDHAVVIRRAIEKTVNRDKVHTKDLGGDATTSKVVENILKEVQ 377 Query: 361 R 361 + Sbjct: 378 K 378 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 130/384 (33%), Positives = 190/384 (49%), Gaps = 42/384 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 MK+ RI IPGDGIG EV + ++V++AA +GF+L + E+Y +++PD Sbjct: 1 MKSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPY-GAEHYLSTRQVLPDH 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 E++ DA+ GA+G P P I G LLK R FDQY N+RPVR F P PL Sbjct: 60 ALEEMEGLDALLLGAIGDPRVQP-GILERGILLKLRFHFDQYANIRPVRSF--TPGPL-- 114 Query: 122 KQPGDIDFYVVRENTEGEYSSLGG----------RVNEGT-------------EHEVVIQ 158 G ++ V+RENTE Y +G V G +Q Sbjct: 115 ---GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKRFAMQ 171 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T G R +YAF+LA + +T ATKSN + ++ +A Y + Sbjct: 172 VAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYESVSL 231 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 +++D LC + V P F V++ N+FGDI+SDL G +G+APS N+ S+ Sbjct: 232 RVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDR---LSM 288 Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP- 337 FEPVHGSAPDI G++ ANP+A+I +GAM+L LG A + A++ ++ Sbjct: 289 FEPVHGSAPDIAGQDRANPVASILSGAMLLRHLGETS-----AAKAMEDAVQRYLSGPVE 343 Query: 338 -KTPDMKGNATTPQVADAICKIIL 360 +M G T DA+ + + Sbjct: 344 ELPIEMGGRLGTRGAGDAVVRRLE 367 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 153/353 (43%), Positives = 203/353 (57%), Gaps = 17/353 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 MR+A IPGDGIG EV+ EG++VL+A A + + + G+++PD + Sbjct: 1 MRLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDL-GASRWQRTGELLPDTVLD 55 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L R DAI GA+G P VP I G LL+ R E D +VNLRP RLF GV PLA P Sbjct: 56 ELRRHDAILLGAIGDPS-VPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPLAA--P 112 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 G ID VRE TEG Y GG + T HEV + S+ T GV+R++RYAFE A +RPR+ Sbjct: 113 GAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALARPRR 172 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 LT K+N L + W VE ++ +PE+ QH+D FV P RFDV+V N Sbjct: 173 HLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVIVTDN 232 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDI++DL A TG IG+A S NL+ T PS+FEPVHGSAPDI GK +A+P AT+ + Sbjct: 233 LFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTATVLSV 292 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICK 357 ++LD LG D+ + AA+ ++ T D + T V D + Sbjct: 293 GLLLDHLGRADQ-----ARKVNAAVAFDLS----TRDPEAQVRTEDVGDRLAA 336 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 119/408 (29%), Positives = 179/408 (43%), Gaps = 62/408 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + +PGDGIG +VLP+ IRVL+A GF ++ + E + + G +PD Sbjct: 1 MARPTVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADI-GWECWCNEGNALPDR 55 Query: 62 WHEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVR 110 + L + FGA+ P+ +S + ++ R+ F+ V +RP Sbjct: 56 TIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCL 115 Query: 111 LFPGVP------CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT------------- 151 FPG P G + +D V R+NTEG Y+ + Sbjct: 116 SFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAA 175 Query: 152 -----EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 E+ + + T++ RI AF+ A+ K +T K N L + +E Sbjct: 176 FANTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVA 235 Query: 207 EAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 + + + YPEI +ID PE + V+VASNLFGD++SD G +G A S Sbjct: 236 KQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAAS 295 Query: 267 ANLNPERTFPSLFEPVHGSAPDIYGKN--IANPIATIWAGAMMLDFLGNGDERFQQAHNG 324 N+ E ++FEP HGSAP N I NPIA I + AMMLD +G ++ + Sbjct: 296 GNIGDE---VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDHIGESEK-----ADR 347 Query: 325 ILAAIEEVIAHGP-KTPDM-----------KGNATTPQVADAICKIIL 360 I AI +V+ G +T DM +G A T Q+ DAI + Sbjct: 348 IRKAIADVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVE 395 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 323 bits (828), Expect = 7e-87, Method: Composition-based stats. Identities = 113/360 (31%), Positives = 174/360 (48%), Gaps = 15/360 (4%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+I +PGDGIG E++ +RVL+AA++R+ L + A HG + E Sbjct: 1 MKIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIG-HDIAGHASLQRHGATVTPALLE 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ D + G + D + FR+E D Y N+RP R FPG+ + Sbjct: 60 KVKAADGLMLGPMATYDFKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAH-----RV 114 Query: 125 GDIDFYVVRENTEGEYSS---LGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G+ + VVRENTEG Y+ G + VI TR +RI R AF+LA++R Sbjct: 115 GEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDLARTR 174 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R ++ K+N L I + + +A +P++R D +D + A V P+RFDV+V Sbjct: 175 AR-HVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFDVIV 233 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +N+FGDILSDL +G++G+ S N + ++ + VHGSAPDI G+NIANP + I Sbjct: 234 TTNMFGDILSDLTAELSGSLGLGGSLNAGKDH---AMGQAVHGSAPDIAGRNIANPYSLI 290 Query: 302 WAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + +L + G F A I + T D G T + + + + Sbjct: 291 LSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRDAGGELGTAEAGQSFVRRL 350 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 93/359 (25%), Positives = 161/359 (44%), Gaps = 29/359 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++ IP DGIG+ ++ + V Q G + FE+ +D Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKSF--NDIK 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G I + R + D Y N+ + +P V + Sbjct: 99 TSVLRNGTALKGNWATSM----GIDSKSYNVLLRHDLDLYANVVKFKSYPTVIT-----R 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D V+RENTEGEY++L G V+ + T++ +RI +YAF+ A R Sbjct: 150 HNNVDLIVIRENTEGEYTNLEHENIPG----VIEMIKIITKKKSERIAKYAFDYAMENNR 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + + + +AE YPEI ++ ID + V +PE+FDV+V Sbjct: 206 KKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFDVIVTP 265 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G++LS++ A G G+ N +FE S DI KNIANP++ ++ Sbjct: 266 NLYGNVLSNIAAALVGGPGLPHGENHG---NGIHVFESGTRNSGMDIATKNIANPMSMLF 322 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKIIL 360 A +L L + + I + I +++ +T D+ GN +T + + + K + Sbjct: 323 AATALLRHL-----QLSKHAQLIESCIHKIVTTNQARTVDIGGNTSTSEFFEILVKEVE 376 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 109/404 (26%), Positives = 168/404 (41%), Gaps = 64/404 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + I GDGIGK+V P +VL+AAA G +S+ ++ +A + + +PDD + Sbjct: 35 VPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRV-FAGESAREKYDENLPDDTVNAI 93 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 G + P + R+ D Y N+RP GVP P+ P + Sbjct: 94 DEHRVAIKGPLTT----PVGAGFRSLNVALRQTLDFYSNVRPTYYLDGVPSPMKA--PEE 147 Query: 127 IDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTRRGV 167 +D RENTE Y+ + +V I T G Sbjct: 148 MDMVTFRENTEDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIGIGIKPITEFGS 207 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENYPE----------- 215 R++R A + A R +T K N + + + E +A E YP+ Sbjct: 208 KRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPDDEVFAAPDSLW 267 Query: 216 ------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 + + + D + ++ + F V+ NL GD LSD A G +GI Sbjct: 268 ETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSDAAGAQIGGLGI 327 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP AN R L EPVHGSAP G+N+ANP A I +G +M D++G ++ A + Sbjct: 328 APGANFGDAR---VLAEPVHGSAPKRAGQNMANPTAMILSGRLMFDYMG-----WKDAAD 379 Query: 324 GILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIILR 361 + A+EE I+ G T D++ T + +DAI + I + Sbjct: 380 LVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 103/385 (26%), Positives = 169/385 (43%), Gaps = 49/385 (12%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 ++IA +PGDGIG EV + V + + + E++ G +P Sbjct: 6 PIKIAVLPGDGIGIEVTEATLPVFEVL----DVPVILNYGDI-GWEFWKKEGAAIPSRTW 60 Query: 64 EQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVRLF 112 + ++ D + GA+ + +++ R+ D + N+RP Sbjct: 61 QLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSI 120 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT---------------EHEVVI 157 P +F ++REN+EG Y E Sbjct: 121 DDQSKPF--------NFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASC 172 Query: 158 QESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 + ++ G+ R+ +AF+ A +T A K N L S + + E+ A+ YP+I+ Sbjct: 173 ALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQ 232 Query: 218 WDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPS 277 D ++D + + PE+F V+VA N+FGDILSD+G G +G+APSAN+ + ++ Sbjct: 233 ADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKGSY-- 290 Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 FEPVHGS P I KN ANP A +M+L+ G D I+ A+ +VI Sbjct: 291 -FEPVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPDR-----AKKIVNAVMQVIKEKR 343 Query: 338 -KTPDMKGNATTPQVADAICKIILR 361 T D+ G+ATT +A+A+ + R Sbjct: 344 FITYDLGGHATTTDMANAVIEHCAR 368 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 116/387 (29%), Positives = 164/387 (42%), Gaps = 52/387 (13%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M RI +PGDGIG EV+ + V+ A + + + G+ +P Sbjct: 5 MLRKRICVLPGDGIGIEVMEAALPVIAAL----NLPFDLVPADI-GWQCWRAEGETVPAR 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTV-----------PDHISLWGSLLKFRREFDQYVNLRPVR 110 E ++ DA GA+ + +++ R+ D Y N+RPV Sbjct: 60 TWEIMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVT 119 Query: 111 LFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGR-------------------VNEGT 151 G F V+RENTEG Y+ L Sbjct: 120 DMTG---------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 152 EHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE 211 + + + + TR G+ RI YAFE A+ +T K L S + EA A+ Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 YP++ +++D + V +PERF V+VA N+FGDILSDLG G +G APS N Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 + FEPVHGSAP G N ANP A A A+ML+ LG F I A+ Sbjct: 291 SG---AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLG-----FPTESACISQAVSL 342 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKI 358 V +T D+ G+ TT QV +AI + Sbjct: 343 VSRTSTRTYDLGGSHTTAQVGEAIVQQ 369 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 125/356 (35%), Positives = 172/356 (48%), Gaps = 37/356 (10%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+A IPGDGIG EV+ +RVL+A R + FE E + + G + ++ E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYE-GGVDVFQECGSPIREEDLE 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 ++ R DA+ FGA P +P +L R+E Y NLR + P + Sbjct: 57 EIRRSDAVLFGATTTPFDLP---GYRSLILTLRKELGLYANLR---IIPDLRT------- 103 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + +VREN+EG Y +G V + + + TR G +RI R+A E A++R Sbjct: 104 -GREIVIVRENSEGLYFGIGAVV-----NGRAVDVRLITREGAERIARFAVEQAKARG-S 156 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 +T K+N L ++ V +A + ID + V P V+++ N Sbjct: 157 FITFVHKANVL-TGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVILSEN 214 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 LFGDILSDL G+IGI PS N +LFEPVHGSAPDI GK IANPI I +G Sbjct: 215 LFGDILSDLATVHAGSIGIVPSGNYGD---GIALFEPVHGSAPDIAGKGIANPIGAILSG 271 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 AM+LD+LG I AA+ + +G TPDM G A T V I I Sbjct: 272 AMLLDYLGLDGS-------LIRAAVRGYVVNGELTPDMGGRARTEDVVRGIIGEIE 320 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 107/414 (25%), Positives = 167/414 (40%), Gaps = 72/414 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG ++ RV+ AA E+ G + A + + G+ +P + + Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + G + P + + R+E D + LRPVR F GVP P+ +P Sbjct: 81 TIKEYLIAVKGPLTTPI----GGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVK--RP 134 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTRR 165 D+D + RENTE Y+ + + +V I ++ Sbjct: 135 QDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKE 194 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDER-------------------- 205 G +R++R A + A RK++T K N + + + + Sbjct: 195 GTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGDQVFTWQQYD 254 Query: 206 -------------VEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSD 252 + AE +I DI + + +P DVV NL GD +SD Sbjct: 255 EIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISD 314 Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 A G IGIAP AN+N E T ++FE HG+AP G N NP + I + +ML+ LG Sbjct: 315 ALAAQVGGIGIAPGANINYE-TGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLG 373 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKIIL 360 +Q+A + I +IE+ IA T D +T AD + K + Sbjct: 374 -----WQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK 422 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 105/382 (27%), Positives = 167/382 (43%), Gaps = 43/382 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++ +PGD IG E++ E +++L E G + D Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPG---V 115 + E DA+ G+VG P+ VP +S +L R+ D + N+RP R + Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKGILHLRQRLDAFANIRPCRFYASSLLN 120 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 PL + +DF +VREN G Y + R V+R R + Sbjct: 121 QSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARVSA 168 Query: 176 ELAQSRPRKT---------LTSATKSNGLAISMPYWDERVEAMAE-NYPEIRWDKQHIDI 225 LA++ R + +A K+N LA S +W + E +P+I Q D Sbjct: 169 ALARTFGRGKNTDDKSPAIVWNADKANVLA-SGRFWRTVTHDIFEREFPDIELHDQLADS 227 Query: 226 LCARFVMQPERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFE 280 + V P +F+ V+ N FGDILSD+ G++G+ PSA++ E+ ++E Sbjct: 228 MAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYE 287 Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA------ 334 VHGSAPDI G ANPIA I + AM+L + + + + A+ + + Sbjct: 288 AVHGSAPDISGTGQANPIAQILSLAMLLRY----SFSMPRQADLLEDAVRKTLEVREHGG 343 Query: 335 HGPKTPDMKGNATTPQVADAIC 356 G +T D+ G+A+T V DA+ Sbjct: 344 LGIRTKDLGGSASTQDVGDAVA 365 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 103/406 (25%), Positives = 158/406 (38%), Gaps = 65/406 (16%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWA-SCEYYSHHGKMMPDDWHE 64 I I GDGIG EV I+V A E+ +G + E + G +PD E Sbjct: 47 IGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLPDQSIE 106 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L + + P + R+ FD Y N+RPV+ FPG+P PL +P Sbjct: 107 VLRKIRVFLKAPLET----PVGGGFRSINVTLRQLFDLYANIRPVKYFPGLPSPLR--RP 160 Query: 125 GDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFTRRGVD 168 +D + RENTE Y+ + + I ++ G Sbjct: 161 ELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPISKFGTQ 220 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA--------------ENYP 214 RI R A + A R+ +T K N + + E +A Y Sbjct: 221 RIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFEDELAQYG 280 Query: 215 E------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN 268 + + + D + + + + +DV++A NL GD +SD G +G+AP + Sbjct: 281 GSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLGVAPGLD 340 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + + + EPVHG+AP GKN NP ATI A +M FLG +++ I+ Sbjct: 341 VGD---WGMMAEPVHGTAPKYRGKNYVNPTATILALELMFRFLG-----WREVAEYIMKG 392 Query: 329 IEEVIAHGPKTPDMKGNAT-------------TPQVADAICKIILR 361 +E G T D+ T T + AD + +II R Sbjct: 393 VETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIKR 438 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 314 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 100/401 (24%), Positives = 158/401 (39%), Gaps = 62/401 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG E+ + ++ A E+ G + A + G+ +P + + Sbjct: 41 IPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQETLD 100 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 L G +G P + RR FD Y +RPV G P+ P Sbjct: 101 VLKESIVGIKGPLGT----PVGKGVRSINSALRRAFDYYSAVRPVYWM-GQATPIPN--P 153 Query: 125 GDIDFYVVRENTEGEYSSLGGRVN-------------------EGTEHEVVIQESVFTRR 165 +D V RENT+ Y+ + EG +V I + Sbjct: 154 ERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVGITVKPMSEF 213 Query: 166 GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN------------- 212 R +R A A +K + K N + + + +AE Sbjct: 214 KTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFKGKVVTDPEA 273 Query: 213 ---YPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANL 269 +++ K D + + V++PE +DV++A NL GD +SDL + G G PS N+ Sbjct: 274 EPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIGGPGFVPSGNI 333 Query: 270 NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAI 329 +LFE HG+A DI GK IANP++ +GAMML+++G +++A + A+ Sbjct: 334 GDGY---ALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEYIG-----WKEAAQKVYDAV 385 Query: 330 EEVIAHGPKTPDM----------KGNATTPQVADAICKIIL 360 +A TPD+ T + A+ I K I Sbjct: 386 RRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 132/370 (35%), Positives = 182/370 (49%), Gaps = 26/370 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW-ASCEYYSHHGKMMPD 60 M RI I GDGIG E++ +RVL A AE + +E +E A + Y G + Sbjct: 1 MTGTRIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAE 60 Query: 61 DWHEQLS-RFDAIYFGAVGWPD-TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 +L DA G VG PD PD + R D Y N+RPVR +PGVP Sbjct: 61 ADVRRLRDEVDATLKGPVGLPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSR 120 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + + +D+ +VRENTEG Y+S G V V + TR G R+ R AF LA Sbjct: 121 VRADR---VDYVIVRENTEGLYASRGKGVGNRW---AVTDTLLTTREGTLRVARKAFTLA 174 Query: 179 QSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 R + +T KSN L S ++ E V +A +PE+ + ++ D V+ Sbjct: 175 AGRQGAPADGVRRVTCVDKSNVLR-SHAFFREVVTEVAAEFPEVELEYRYADAAAQDLVL 233 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 PERFDV+V N GD+LSDLG A G +G+ P+ N+ + FEPVHGSAPD+ G+ Sbjct: 234 CPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD---GAAYFEPVHGSAPDLVGR 290 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA--TTPQ 350 N ANP+ + A AM+LD LG+ DE + A+ V+A G + G Sbjct: 291 NRANPVGQLLAAAMLLDHLGHVDE-----AARLRRAVSAVLAFGTVRIEADGTVLGGAEA 345 Query: 351 VADAICKIIL 360 VADA+ + Sbjct: 346 VADAVIAALQ 355 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 313 bits (803), Expect = 6e-84, Method: Composition-based stats. Identities = 109/365 (29%), Positives = 170/365 (46%), Gaps = 12/365 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 M+IA I GDGIG +V I VL+ A + G A Y+ G + D E Sbjct: 1 MKIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEE 60 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DAI+ GA+G P + + L+ R F Y +RPV+ +P P LA + Sbjct: 61 RAGLADAIFLGAIGLPSIRHANGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQRLADPRA 120 Query: 125 GDIDFYVVRENTEGE-YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR-- 181 ID ++RE+TEG YS+ + + + V TR+ ++ R+AF LA+ R Sbjct: 121 AGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLARKRRE 180 Query: 182 --PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 LT K+N S+ ++ + + + + ++ ++D V +P FDV Sbjct: 181 RGHPGRLTCVDKANVF-TSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPWEFDV 239 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +V N+FGDILSDL G +G+A + LF+P HGSAPDI G++ ANP+A Sbjct: 240 LVMENMFGDILSDLAGGLVGGMGMAACGEIGD---TTGLFQPAHGSAPDIMGEDKANPLA 296 Query: 300 TIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAIC 356 I + A+MLD+L A I +A+E H + + G+ T V + Sbjct: 297 AILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKELL 356 Query: 357 KIILR 361 + + Sbjct: 357 GRVAQ 361 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 88/358 (24%), Positives = 161/358 (44%), Gaps = 25/358 (6%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + +PGDG+G E++ V +AAA + F++ + + + K+ + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL--EQVL 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P ++ ++ RR+ D + N+ V+ PG + Sbjct: 102 SSMKENKVAIIGKIHTPMEYKGELA--SYDMRLRRKLDLFANVVHVKSLPGYMT-----R 154 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ++D ++RE TEGEYSSL G V+ + TR RI ++AF+ A + R Sbjct: 155 HNNLDLVIIREQTEGEYSSLEHESARG----VIECLKIVTRAKSQRIAKFAFDYATKKGR 210 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 +T+ K+N + + + + E +AE YP+I+++ ID C + V P +FDV+V Sbjct: 211 GKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFE-PVHGSAPDIYGKNIANPIATIW 302 NL+G+I+ +L G G+ P + + E ++FE G+NIANP A + Sbjct: 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEY---AVFETGARHPFAQAVGRNIANPTAMLL 327 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + ML L N + + + + +T DM G +TT ++ + Sbjct: 328 SASNMLRHL-NLEYHSSMIADA---VKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 381 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 106/380 (27%), Positives = 157/380 (41%), Gaps = 39/380 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M+ + I GDG G E++ VL AA GF L ++ A G+++P Sbjct: 1 MRKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRP-AGQGALRSVGELLPAS 59 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + R G P + + RRE D Y +RPVR++PG AG Sbjct: 60 TLDSIRRNGVALKGPTTTPI----GVGHRSVNITIRRELDLYACVRPVRVWPG-----AG 110 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGT--------------EHEVVIQESVFTRRGV 167 ID VVRENTE YS L + + + T G Sbjct: 111 AVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPITPGGS 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 RI+ +A + A+ R+ + + + E + YP+I + +LC Sbjct: 171 RRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPVTVLC 230 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 V P DV+V NL+GD++SD+ A G +G+AP AN+ ++FE HGSAP Sbjct: 231 DSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR---TAVFEATHGSAP 287 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM---- 342 + G N NP A I +G M+LD LG I AA+ V+ G T D+ Sbjct: 288 EFAGSNRLNPTALILSGCMLLDHLGEAPT-----AARIRAAVRSVLEEGRSVTFDLLPPD 342 Query: 343 --KGNATTPQVADAICKIIL 360 TT A+A+ + + Sbjct: 343 RAARAVTTTAYAEAVIERLR 362 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 313 bits (801), Expect = 8e-84, Method: Composition-based stats. Identities = 102/417 (24%), Positives = 155/417 (37%), Gaps = 70/417 (16%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 I I GDGIG E+ V AA ++ G A Y G+ +P Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 D L + G + P I + R++ D Y RPV +PG P P+ Sbjct: 76 DKTLATLREYLVGIKGPLTTPI----GIGHRSINVTLRQKLDLYACFRPVTYYPGTPSPV 131 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQES 160 P +++ V RENTE Y+ + V+ E Sbjct: 132 --VHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSAFAIK 189 Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE----- 215 +++G R++ A + A + R TLT K N + + + + AE Y + Sbjct: 190 PISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDKVFTW 249 Query: 216 ---------------------------IRWDKQHIDILCARFVMQPERFDVVVASNLFGD 248 + + D + ++ PE F+VV NL GD Sbjct: 250 NQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATMNLNGD 309 Query: 249 ILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML 308 +SD A G IGIAP N+N +T ++FE HG+AP G+N NP + I +GAMM Sbjct: 310 YISDALAAQVGGIGIAPGGNIN-YQTGHAIFEATHGTAPQFAGQNKLNPTSIILSGAMMF 368 Query: 309 DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN-----ATTPQVADAICKIIL 360 D+LG + N I I+ I T D +T + + ++I Sbjct: 369 DYLG-----WDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIE 420 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 313 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 102/394 (25%), Positives = 167/394 (42%), Gaps = 55/394 (13%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK------- 56 ++ +PGD G +++ + VL + + + + + C + K Sbjct: 14 RYKVCYMPGDDSGFDMMEGALVVLLSM----DLPIDWVRADLGWCMWEKSVNKFGQGDPR 69 Query: 57 --MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 +P + +++ DA A+ V ++L+ R+ FD Y+NLRP + P Sbjct: 70 CNTVPPETIDKIRSSDATLMAAITSKSGV---KGFKSAILQMRQLFDLYINLRPAKTLPD 126 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLG-------------GRVNEGTEHEVVIQESV 161 + PL G ID + RENTE YS++ G +V + V Sbjct: 127 LGSPLKGD--PKIDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDVAVSWRV 184 Query: 162 FTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWD-- 219 F+ G +RI+R AFE A+S R + K+N + + +A+ Y + Sbjct: 185 FSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQYGITGI 244 Query: 220 KQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLF 279 +++ D + P+ + V+V SN+FGDILSD TG +G APS N+ ++F Sbjct: 245 EENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGEN---TAIF 301 Query: 280 EPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH---G 336 EP GS P + NP A + MML++LG QA I AI EV+ Sbjct: 302 EPCSGSVPKYAHQYRVNPSAMLLTSKMMLEYLG-----LDQAGQKIEWAINEVLKENRPK 356 Query: 337 PKTPDM-----------KGNATTPQVADAICKII 359 T D+ + A+T ++A AI + I Sbjct: 357 TLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 313 bits (801), Expect = 1e-83, Method: Composition-based stats. Identities = 100/360 (27%), Positives = 157/360 (43%), Gaps = 30/360 (8%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + +PG GIG E + + + G + FE ++ Sbjct: 56 RHAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDPTMDNDDD----VQYAI 107 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + + + R E D Y + + +PGV + Sbjct: 108 TTIKRNGVGLKGNIETKSEA---AYVTSRNVALRNELDMYAYILNCKSYPGVAT-----R 159 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 DID ++R+NTEGEY+ L G VV V T +R+ R+AFE A+ R Sbjct: 160 HKDIDVVIIRQNTEGEYAMLEHESVNG----VVESMKVVTADNSERVARFAFEFAKKNGR 215 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T+ K+N + +S + E +A+ YP+I D ID C + V +P +FDV++ + Sbjct: 216 KKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLMT 275 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL+G I+S++ G G+ N ++FEP + I GKNIANPIA I Sbjct: 276 NLYGSIVSNVVCGLLGGAGLLSGRNYGDHY---AVFEPGTRNTGTAIAGKNIANPIAMIN 332 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIILR 361 A ML+ LG+ Q + + AI + I TPD+ G+ T+ V AI + + R Sbjct: 333 ASIDMLEHLGH-----QFHASLLRRAINKTINVDRVLTPDLGGSNTSTDVVGAILQNVGR 387 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 309 bits (792), Expect = 9e-83, Method: Composition-based stats. Identities = 96/407 (23%), Positives = 164/407 (40%), Gaps = 63/407 (15%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG---FALSFEQMEWASCEYYSHH-GKM 57 K I I GDGIG ++ P I+V+ AA E+ +++ ++ + Sbjct: 26 PKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTW 85 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 +P + + + + G + P + + R++ D YV RPVR F GVP Sbjct: 86 LPQETLDAVRDYVVSIKGPLTT----PVGGGIRSLNVALRQQLDLYVCQRPVRWFEGVPS 141 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQ 158 P+ +PGD+D + REN+E Y+ + + +V I Sbjct: 142 PVK--KPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFTENCGIG 199 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY----- 213 ++ G R++R A + A R ++T K N + + + + +A + Sbjct: 200 IKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARDEFGAEL 259 Query: 214 ---------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + D + + +++P +DV+ NL GD LSD A Sbjct: 260 LDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSDALAAEV 319 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G IGIAP ANL+ ++FE HG+AP G++ NP + I + MML +G + Sbjct: 320 GGIGIAPGANLSDS---VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRHMG-----W 371 Query: 319 QQAHNGILAAIEEVIAHGPKTPD----MKGN--ATTPQVADAICKII 359 +A + I+ IA T D M G + + DA+ + Sbjct: 372 TEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 308 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 143/385 (37%), Positives = 196/385 (50%), Gaps = 35/385 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 ++ ++A +PGDGIG EV+ L+A G AL ++ W + ++ HG+MMP DW Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEAL---PGPALVLTELGWPAHAWHRDHGEMMPADW 62 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISL-------WGSLLKFRREFDQYVNLRPVRLFPGV 115 QL+ +DA+ GA+G P D LL+ R+ D + RP G Sbjct: 63 RGQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLAGA 122 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 P PL+ + D V+REN+EGEY GGR+ GT E Q VFTR G +RI+R+AF Sbjct: 123 PMPLSDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIRHAF 182 Query: 176 ELA----------QSRPR---------KTLTSATKSNGLAISMPYWDERVEAMAENYPEI 216 E A PR + TK N + + W E +A YP I Sbjct: 183 ERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEYPGI 242 Query: 217 RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP-ERTF 275 + ID C +FV QP +FDVVVASNL GDIL+DL G +G+APSANLNP +R+ Sbjct: 243 ATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPADRSV 302 Query: 276 PSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 P LFEP HGSAPDI G + A+P A + A ML+++G D ++ + A+ E IA Sbjct: 303 PPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAEDIAE 362 Query: 336 GPKTPDMKGNATTPQVADAICKIIL 360 M G +V A+ + I Sbjct: 363 HG----MGGR-GCAEVGRAVAQRIR 382 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 112/373 (30%), Positives = 178/373 (47%), Gaps = 42/373 (11%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG----K 56 M K + A + GDGIG EV+ +RVL+ + L A E + +G Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILCE-----AGSEQWDKNGRKDAS 53 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP 116 +PD + L D + G +P + + R++FD Y N+RP + + Sbjct: 54 YIPDVTMKILEETDCCFKGPTTT---IPVPGAPRSVAVTLRQKFDLYANIRPTKTYD--- 107 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 +D RE TEG Y+ + ++ + I TR+G R++ A + Sbjct: 108 ---RLTPDRKLDCVCFREATEGLYTGVEAKIT----DDAAIAIRKITRQGSRRLIDSAVD 160 Query: 177 LAQSRPRKTLTSATKSNGLAISMP-YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 A K + + TK N L + +WDE +A+ +I + +ID + + V+ E Sbjct: 161 WANKFNMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQMVIATE 218 Query: 236 RFD--VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKN 293 +F+ V+V++NLF DI+S+L A G+IG+ SAN+ ++FE HGSAP G+N Sbjct: 219 QFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDNY---AMFEAAHGSAPQFAGQN 275 Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 NP AT+ +GA M D+LG D R + I AA E+VI G T D+ G+A+T Q+ Sbjct: 276 KVNPTATVLSGAWMADYLGERDVR-----DAIFAATEQVINEGKAVTWDIGGDASTTQMT 330 Query: 353 DAIC----KIILR 361 DAI + + + Sbjct: 331 DAIITYAKEKLRK 343 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 307 bits (786), Expect = 5e-82, Method: Composition-based stats. Identities = 97/400 (24%), Positives = 156/400 (39%), Gaps = 61/400 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKMMPDDWHE 64 +A GDGIG E++ +VL AA ++ +G E A E G ++PD + Sbjct: 35 VAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLPDGTLQ 94 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 G + P + R D Y N+RPV+ + G P P P Sbjct: 95 AFKLARVNLKGPLTT----PVGGGFRSLNVTLRMVLDLYSNVRPVKWY-GQPTP--HCHP 147 Query: 125 GDIDFYVVRENTEGEYSSLGG----------------RVNEGTEHEVVIQESVFTRRGVD 168 +ID+ + RENTE Y+ + + I ++ Sbjct: 148 ENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGIKPISKWRTQ 207 Query: 169 RILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV---------------EAMAENY 213 R +R A E A K +T K N + + + + E + Y Sbjct: 208 RHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVVTEEEVNTKY 267 Query: 214 PE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSA 267 I + + D + + + +P ++V+V NL GD +SD A G IG+A Sbjct: 268 GGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALVGGIGMAAGL 327 Query: 268 NLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGIL 326 ++ ++ EPVHGSAP GKN+ NP A I +G +L DF+G + + + Sbjct: 328 DMGD---GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKL-----LVE 379 Query: 327 AAIEEVIAHGPKTPDM----KG--NATTPQVADAICKIIL 360 A+++ IAH T D+ G +T + D + I Sbjct: 380 YAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 304 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 112/374 (29%), Positives = 176/374 (47%), Gaps = 24/374 (6%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 M T IA + GDGIG EV+ E ++VL+ +R + + + Y++ G PD Sbjct: 1 MTTYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFA-MGHAFPD 59 Query: 61 DWHEQLSRFDAIYFGAVGWPDT-----VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 + + DAI G +G D G+LL RR ++ + N RPV L G+ Sbjct: 60 ETKAACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGL 119 Query: 116 P--CPLAGKQ-PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILR 172 PL ID ++RE G Y V + + + +I++ Sbjct: 120 AHFSPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVK 179 Query: 173 YAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 FE++ R +K + + KSN L S W+E VE ++NYPE+ +D + Sbjct: 180 VGFEVSMKR-KKVMHNIHKSNVLKSS-VLWNEIVEEESKNYPEVEVKNILVDAAATYLCL 237 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGK 292 P FDV+V N+FGDILSD G G++G+ PSA P++++ +EP HGSAPDI GK Sbjct: 238 NPGMFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDKSY---YEPSHGSAPDIAGK 294 Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM-----KGNAT 347 IANP + I + A+ML+ ++ + AA++ V +G T D+ + Sbjct: 295 GIANPYSMIGSVALMLE----MSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVS 350 Query: 348 TPQVADAICKIILR 361 T + D +C + + Sbjct: 351 TAEFGDLVCAELAK 364 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 304 bits (778), Expect = 4e-81, Method: Composition-based stats. Identities = 116/369 (31%), Positives = 178/369 (48%), Gaps = 31/369 (8%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + EG++VL A +E G + E + Y P D ++ D I GAVGW Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 80 PDTVPDHISL---------WGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG-----KQPG 125 PD + + ++ R + Y N+RP++L+PGV + G + G Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK- 184 +D ++RENTEG Y+ GG++ G + +V I V TRR ++++R+AFEL + R + Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 185 ------TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD 238 +T+ K N L + + + YPEI D +D V QPE +D Sbjct: 181 PKDGKLRVTAIIKDNVL-HGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYD 239 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPI 298 V V SN+FGDI++DL G +G+A N+ ++FEP+HGSAP GK+ NPI Sbjct: 240 VCVTSNMFGDIVTDLASTLQGGMGMAVGGNIG---KHNAMFEPIHGSAPKHAGKDKVNPI 296 Query: 299 ATIWAGAMMLDFLGNG--DERFQQAHNGILAAIEEVIAHG-PKTPDMKGN---ATTPQVA 352 A I + L++L D +A I AA+ EV+ G T D+ GN + +V Sbjct: 297 AMILSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVG 356 Query: 353 DAICKIILR 361 AI + +R Sbjct: 357 SAIAEAAVR 365 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 303 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 91/409 (22%), Positives = 163/409 (39%), Gaps = 71/409 (17%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEY--YSHHGKMMPDD 61 I I GDGIG ++ P I+V+ +A ++ +++ ++ Y + H ++ P++ Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 62 ------WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 E ++ + G + P + R++ D YV LRPVR + G Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPI----GEGFRSLNVALRQKMDLYVCLRPVRWY-GS 146 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVV 156 P P+ P +D + REN+E Y+ + + Sbjct: 147 PSPVKE--PQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSG 204 Query: 157 IQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMA-ENY-- 213 + ++ G +R++R A E A + ++T K N + + + + A+A + + Sbjct: 205 VGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNA 264 Query: 214 -----------------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 EI D + +++P + V+ NL GD +SD A Sbjct: 265 QVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAA 324 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G IGIAP ANLN +FE HG+AP G + NP + I + MML +G Sbjct: 325 MVGGIGIAPGANLND---TVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHMG---- 377 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG------NATTPQVADAICKII 359 + +A + I++A+E+ I T D + A + + + Sbjct: 378 -WVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 96/399 (24%), Positives = 164/399 (41%), Gaps = 61/399 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGF---ALSFEQMEWASCEYYSHHGKMMPDDWH 63 IA I GDG+G++V+P +V+ +A + + Q+ + G P + Sbjct: 34 IAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDWFPQETI 93 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + G + P + R+E D +VN+R ++ F +P PL Sbjct: 94 NAVRECKIAIKGPLTTPL----GGGFRSLNVALRQEMDLFVNMRTIKGFSALPSPLKNPY 149 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFTR 164 + V+R+++E YS + + +V I ++ Sbjct: 150 L--TNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFTQECGIGIKNISK 207 Query: 165 RGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-NY---------- 213 G +R++RYA A ++LT K N L + + A+A+ Y Sbjct: 208 EGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKREYQAIDDENGRW 267 Query: 214 --------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 P + + D + + +M PE+FDVV +N GD L+D+ A G +GI P Sbjct: 268 LHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADMLSAQVGGVGIMP 327 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGI 325 +ANLN E + FEP HG+ I G+N ANP ++I + +ML F+ ++ +A N I Sbjct: 328 AANLNNE---VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKFM-----QWHEAANLI 379 Query: 326 LAAIEEVIAHGPKTPDMKG------NATTPQVADAICKI 358 A+E +A G T D+ + A + + Sbjct: 380 ENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 96/402 (23%), Positives = 155/402 (38%), Gaps = 64/402 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH---HGKMMPDDW 62 I I GDGIG +V P ++V+ AA + +G E +E + E + +P++ Sbjct: 29 IPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEET 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 L + G + P + + R+ D YV RPV+ F GVP P+ Sbjct: 89 LNILQEYKVSIKGPLTT----PVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-------------------VIQESVFT 163 +P ++D + RENTE Y+ + + V I + Sbjct: 143 RPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVS 202 Query: 164 RRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY---------- 213 + G R++R A + A + ++T K N + + + + +A Sbjct: 203 KEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIEEFGASLLHGGP 262 Query: 214 ----------PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGI 263 EI D + + +++P + V+ NL GD LSD A G IGI Sbjct: 263 WCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQVGGIGI 322 Query: 264 APSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHN 323 AP ANL E ++FE HG+AP GKN NP + I + MML +G + + Sbjct: 323 APGANLGDE---VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWLE------AD 373 Query: 324 GILAAIEEVIAHGPKTPDMKGNA------TTPQVADAICKII 359 +L + I T D + + D I + Sbjct: 374 LLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 300 bits (769), Expect = 4e-80, Method: Composition-based stats. Identities = 117/355 (32%), Positives = 176/355 (49%), Gaps = 30/355 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I I GDGIG+EV+P + VLQA E SF + + A + G +P+ +E Sbjct: 7 HEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTE-KQAGDDTRDQTGAALPETTYE 62 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + DA FGA G +L R +VN+RP R +PGV Sbjct: 63 AAADADATLFGAAGETAA--------DVILPLREAVGSFVNIRPARAYPGV-----DALQ 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 + D +RENTEG YS R++E ++ V T +++ YA R Sbjct: 110 PETDLVFLRENTEGVYSGHEDRLSE----DLSTLTRVITTSASEQLAEYACSYVTERSID 165 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 + K+N + + + + V +A + ++ ++ +D R + P +FDVVV N Sbjct: 166 GFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLNPTQFDVVVCPN 224 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 L GD+LSDL G +G+ PSAN+ +LFEPVHG+APDI G IANP A+I + Sbjct: 225 LAGDVLSDLAAGLVGGLGLLPSANIG---QTNALFEPVHGTAPDIAGDGIANPSASILSA 281 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 M+L++LG D A + A+E V+ GP+TPD+ GNA+T V +A+ + + Sbjct: 282 GMLLEYLGETD-----AATNVQMAVESVLNSGPRTPDLGGNASTEAVVNAVIEQL 331 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 297 bits (760), Expect = 5e-79, Method: Composition-based stats. Identities = 87/374 (23%), Positives = 149/374 (39%), Gaps = 39/374 (10%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K ++ + GD IG EV+ E + + +G + + H + + Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGG-SCLDQHDCPIQES 68 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHI--SLWGSLLKFRREFDQYVNLRPVRLFPGVP--- 116 ++ S A+ G+VG P +L+ R+ + Y N+RP ++ Sbjct: 69 TLQEASECHAVLLGSVGGPKWDVGDSSRRPETGILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 L ++ +REN G Y + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI--RWDKQHIDILCARFVMQP 234 LA S + S K+N +A S + E + + +P++ + Q +D P Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 235 ERFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLN-------PERTFPSLFEPVHGSA 286 + + VV+ NLFGDILSDL G++G+ SA ++ R +++PV GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 PDI GK IANPI + +M + +A + I +AI++ + G T D+ G Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRW----SLGLPKAADAIDSAIKDCLESGQCTRDVGGTL 345 Query: 347 TTPQVADAICKIIL 360 +T Q A+ + I Sbjct: 346 STQQAGSALRQSIQ 359 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 295 bits (755), Expect = 2e-78, Method: Composition-based stats. Identities = 96/405 (23%), Positives = 158/405 (39%), Gaps = 69/405 (17%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASC----------------- 48 ++ +PGDGIG E+ + A + ++ + Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYA----NIPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 49 -EYYSHHGKMMP-----------------------DDWHEQLSRFDAIYFGAVGWPDTVP 84 E G+ P D H+ + + G D Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGPFITRDVSK 154 Query: 85 DHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLG 144 + ++ Y ++ PV+ +P P D+D VVRENTE EYS L Sbjct: 155 SIDRMLAL------KYGLYAHVVPVKAPQNLP-PSVFTPFRDVDMVVVRENTEAEYSGLE 207 Query: 145 GRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDE 204 +V G VV + TR G RI ++AFE A+ R + + K+N + S + E Sbjct: 208 HQVQPG----VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIE 263 Query: 205 RVEAMAENYPEIRWDKQHIDILCARFVMQPERFD--VVVASNLFGDILSDLGPACTGTIG 262 + +A+ YP+I++ + +D + V P FD VVV NL+G I+S+ + G +G Sbjct: 264 CCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVG 323 Query: 263 IAPSAN---LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQ 319 + N +N + A DI G+ IANPI I + MLD +G Sbjct: 324 VISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDHMG-----MN 378 Query: 320 QAHNGILAAIEEVIAH---GPKTPDMKGNATTPQVADAICKIILR 361 N I A++E + + TPD+ G ++ +A+ + I + Sbjct: 379 THANRIKFALKETLLNANPKILTPDIGGTGSSVSFIEAMMRHIPK 423 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 294 bits (754), Expect = 3e-78, Method: Composition-based stats. Identities = 120/364 (32%), Positives = 173/364 (47%), Gaps = 30/364 (8%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + RI AIPG+GIG EV+ +++LQ A+ GF L W + G P Sbjct: 7 ASYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQ-VDYGWLGATAFEQLGSYFPQAT 65 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLA 120 E D I FGAV G LL+ R+ FD + NLRP+R + L Sbjct: 66 TELCDGADGIVFGAVS-----------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSLR 114 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ++ +D +VRE G Y GR ++ + + + RI R A E AQ Sbjct: 115 PEKIQGLDILIVRELVSGIYFGPSGRSSDERGN-YGYHTMRYYDEEIRRIARKALEQAQY 173 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R R LT A K N L +W V+ A +P + + +D L + V+ P+RFDV+ Sbjct: 174 R-RGLLTVAHKENALPH--LHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 +ASNLFGDILSD+G A G+IG+ SA+LN L+E +HG+APDI G IANP+ T Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNAN--GFGLYEAIHGTAPDIAGLGIANPLGT 288 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM--KGN---ATTPQVADAI 355 + A +ML G Q + ++A G +T D+ +G T + D + Sbjct: 289 LGACVLMLQQWGEVQAAQQIIAAQ-----DRILAKGYRTADLFTQGEEILVNTATLVDLL 343 Query: 356 CKII 359 + + Sbjct: 344 LEEL 347 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 293 bits (751), Expect = 5e-78, Method: Composition-based stats. Identities = 98/361 (27%), Positives = 174/361 (48%), Gaps = 31/361 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + + +PGDGIG E++ + I+++++ G+ ++ + ++ Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKSC-IYTGYKINIIYNYIGGIS-IDKFNTPITNNLIS 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + D I+ G VG LLK R++F+ + N+RP++ CP Sbjct: 60 IIKYIDTIFLGCVGGYKWNHSIFKPEYGLLKLRKKFNFFTNIRPIK------CPFK---- 109 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV----VIQESVFTRRGVDRILRYAFELAQS 180 +ID +VRE G Y ++ +++ ++ + + R+ R +F LA + Sbjct: 110 -NIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFNLALN 168 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVV 240 R +K L S KSN L + W + + + + Y +++ +ID + +FDV+ Sbjct: 169 R-KKKLCSIDKSNVLE-TFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFDVI 226 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT 300 + SNLFGDI+SDL TG++G+ PS ++N SLFEP HGSAPDI KNIANP+ Sbjct: 227 ITSNLFGDIISDLCSLLTGSLGMLPSISINN--KSLSLFEPCHGSAPDIANKNIANPVGA 284 Query: 301 IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGN------ATTPQVADA 354 + + MM +++ N + N + +I +V+++G T DMK +T + D Sbjct: 285 LLSLVMMFEYVLNDF----KLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDL 340 Query: 355 I 355 + Sbjct: 341 V 341 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 289 bits (741), Expect = 8e-77, Method: Composition-based stats. Identities = 92/359 (25%), Positives = 161/359 (44%), Gaps = 28/359 (7%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + + G GIG E++ +RVL+AA G LS+E +S + ++ D+ Sbjct: 37 KTNVTILTGSGIGPEIMDHTLRVLKAA----GAPLSYEIFALSSKDGSKNND---FDEAL 89 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + P + + FR+ D +V + + FPG+ + Sbjct: 90 TSIRRNRVALKGNIELQSKNP---HIKSRNIIFRKTLDLFVYILFCKTFPGLS-----NK 141 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 G+ID V+R+NTEGEY L G+ V V TR ++R++ +AF+ A + R Sbjct: 142 FGEIDITVIRQNTEGEYLMLEHEPRTGS----VESLKVLTRFNLERLIEFAFDYALTNDR 197 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVAS 243 K +T +N ++ + ++++YP I+ + +++ + P FDV++A+ Sbjct: 198 KLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVILAT 257 Query: 244 NLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP-VHGSAPDIYGKNIANPIATIW 302 NL G ++S+ G G+ N + + ++FEP I G N ANPIA I Sbjct: 258 NLNGSMISNYLNGMLGGPGLTSGINFSAD--GIAVFEPGARNKGSSIVGLNRANPIAMIM 315 Query: 303 AGAMMLDFLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G +L LG + I ++ + +TPD+ G AT + D I + I Sbjct: 316 SGINLLHHLGY-----NKTAEMIHNSVYATLVYDKIRTPDIGGQATAEETVDHIIRHIR 369 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 118/402 (29%), Positives = 166/402 (41%), Gaps = 65/402 (16%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 RI +PGDGIG E+ ++ W + + HG +P + Sbjct: 13 APRRITLLPGDGIGPEITDACRGLIADVFPHWELTET-----QIGWSQWRAHGNPVPQET 67 Query: 63 HEQLSRFDAIYFGAVGW-----------PDTVPDHISLWGSLLKFRREFDQYVNLRPVRL 111 E L R DA A+ P ++ +L+ R+ D + N+RPV Sbjct: 68 WETLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-T 126 Query: 112 FPGVPCPLAGKQPGDIDFYVVRENTEGEYSS----LGGRVNEGTEH-------------- 153 PG DF +VRENTEG YS + H Sbjct: 127 LPGAAA----------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVA 176 Query: 154 -------EVVIQESVFTRRGVDRILRYAFELAQSRPRKT--------LTSATKSNGLAIS 198 EV + V T R+ R A +LA +R +T A K N L S Sbjct: 177 RAVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDS 236 Query: 199 MPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 VE +AE YP++ +D + D + + V P RFDV++A NL GDILSD+G Sbjct: 237 ARVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLI 296 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G +G+A SAN+ ++FEPVHGSAPDI G+ IANP A + + AM + LG Sbjct: 297 GGLGLAASANVGDN---FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSEL 353 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 A + A+ P T D+ G ATT + A+ + Sbjct: 354 APAA-KLREAVYAATRTAP-TLDLGGTATTSEFVAAVRAELG 393 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 287 bits (736), Expect = 3e-76, Method: Composition-based stats. Identities = 97/368 (26%), Positives = 172/368 (46%), Gaps = 40/368 (10%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER--WGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 I GDGIG + + R+L+ + + F+ ++ + E + +P + + Sbjct: 44 IGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAEVLK 103 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 +L I G P ++ + + R+E D + N+RPVR+ Sbjct: 104 ELKECHVILKGPTTTPRKGDPWPNVESANVAMRKELDLFANVRPVRIPE----------- 152 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 ID+ RENTEG Y+ G ++ + +V T G +RI+R AFE A++ + Sbjct: 153 QGIDWTFYRENTEGAYAV--GSKGIHVTEDLGVDFTVVTSGGSERIIRAAFEYAKANGKT 210 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV--MQPERFDVVVA 242 +T+ TK+N + + + + +A++Y +I D +IDI+ A+ + + + F V+V Sbjct: 211 RVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKDFQVMVL 270 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANPIA 299 NL+GDI++D G +G A SAN+ S+FE +HGSAP + + A+P + Sbjct: 271 PNLYGDIITDEAAEFQGGVGTAGSANIGKRY---SMFEAIHGSAPRMVQEGRDQYADPCS 327 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIE-------EVIAHGPKTPDMKGNATTPQVA 352 I AGAM+L +G G + + + A++ +++ G T AT + A Sbjct: 328 VIRAGAMLLAHIGYG-----KEADKLYQALDICTVTEKKLVITGRNTG-----ATGAEFA 377 Query: 353 DAICKIIL 360 D I + I Sbjct: 378 DYIMETIE 385 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 287 bits (735), Expect = 4e-76, Method: Composition-based stats. Identities = 84/298 (28%), Positives = 130/298 (43%), Gaps = 25/298 (8%) Query: 39 SFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRR 98 FE++ +S + + R G + +P S R Sbjct: 1 DFEEVHVSSNADEEDIRNAI-----MAIRRNRVALKGNIETNHNLPP--SHKSRNNILRT 53 Query: 99 EFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 D Y N+ + PGV + DID +VRENTEGEYSSL G VV Sbjct: 54 SLDLYANVIHWKSLPGVVT-----RHKDIDILIVRENTEGEYSSLEHESVAG----VVES 104 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRW 218 + T+ RI YAF+LAQ RK +T+ K+N + + + + +A YP+I + Sbjct: 105 LKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITF 164 Query: 219 DKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSL 278 + +D + V +P++FDV+V NL+G+I++++ G G+ AN ++ Sbjct: 165 ENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVY---AV 221 Query: 279 FE-PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH 335 FE + I KNIANP AT+ A MMLD L + I A+ + + Sbjct: 222 FETATRNTGKSIANKNIANPTATLLASCMMLDHL-----KLHSYATSIRKAVLASMDN 274 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 282 bits (722), Expect = 1e-74, Method: Composition-based stats. Identities = 89/366 (24%), Positives = 158/366 (43%), Gaps = 30/366 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAA--ERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + +PGDGIG ++ + +RV + E + F + + E + +P + Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E D + G P ++ + RR Y +RPVR+ Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVSANSLLRRALQLYAAVRPVRIPE--------- 157 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 ID+ REN EGEY + G + ++ + V TR G +RI R AFE A++ Sbjct: 158 --KGIDWTFFRENIEGEY--IWGNKGIQVDDDLAVDFKVLTRPGAERICRAAFEFAKNNG 213 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQ--PERFDVV 240 + +T TK+N + + + + A+ + YP I ++ +D + A+ Q + V Sbjct: 214 KTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKGMQVF 273 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 + NL+GDI++D+ G +G A S+N+ + +LFE +HG + N A+P Sbjct: 274 LLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQY---ALFEAIHGVGNFLVQHNRAQYADP 330 Query: 298 IATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAI 355 + I A M+ +G + E+ +A + +V+ T D G AT + D + Sbjct: 331 CSLIRAMGEMISHIGYPEKKEQLVKALDICTRTERKVV----ITTDKDG-ATAEEFTDYL 385 Query: 356 CKIILR 361 + R Sbjct: 386 LDTLQR 391 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 276 bits (706), Expect = 1e-72, Method: Composition-based stats. Identities = 92/361 (25%), Positives = 154/361 (42%), Gaps = 29/361 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 ++ + G G+G++ R+ AA + FE + A H +P + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFE-VHLAGRMALEHGKDALPKATFDA 57 Query: 66 LSRFDAIYF------GAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 + VG P + FRR+ + ++RPV PG+P Sbjct: 58 IRECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPSRF 117 Query: 120 AGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 +DF + RE TE Y++ + G VV + T R + AF+ A+ Sbjct: 118 T-----GVDFLLFREITEDLYTASEHEIVPG----VVQSFKIVTEAACLRFFKLAFDTAR 168 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 R RKT+ K+N L ++ + E +A+ YPEI +D C + V +P++F+V Sbjct: 169 KRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEV 228 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + A NL+GD+LSDLG G + + N +++E V+G++ + +++NP+ Sbjct: 229 LAAGNLYGDLLSDLGAGLVGGVSTTAAINKG---NGTTVYEAVYGASHEAVPPDMSNPLP 285 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG-PKTPDMKGNATTPQVADAICKI 358 I +L LG I A+E V+ G +T D+ G ATT DAI Sbjct: 286 LILPAIELLKDLGETGT-----AGRIQKAVETVLLEGRIRTRDIGGTATTTAFTDAIVSR 340 Query: 359 I 359 + Sbjct: 341 M 341 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 276 bits (705), Expect = 1e-72, Method: Composition-based stats. Identities = 109/368 (29%), Positives = 178/368 (48%), Gaps = 45/368 (12%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIGKE++P+ ++ + F S E Y + G + D ++L Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDPSVNFTFY-----NISSERYINKGITIKDSEIDEL 58 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 +++I+FGA+G P I G +L+ R+E D Y+N+RP F + + Sbjct: 59 KSYNSIFFGAIGDFRVKP-GIMEQGVILRLRKELDLYMNIRPAISFSRITG-------NN 110 Query: 127 IDFYVVRENTEGEYSSLGGRVNEG-------------------TEHEVVIQESVFTRRGV 167 I ++REN E YS + G +NE ++ + +R+ + Sbjct: 111 IHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFLSRKNL 170 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 R A+++A + +T+T K+N + + W E +E + + ++ D L Sbjct: 171 KRFFNMAYKIADT---ETVTITDKANAVDMYS-LWREIAIEESEP-AGKKINFEYADSLA 225 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P ++ ++A NL+GDILSD+ A G +G APS N+ + S+FEPVHGSAP Sbjct: 226 YNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD---YSSMFEPVHGSAP 282 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNAT 347 DI GKNIANP+A+I + MML L + + ++E VI +G + GNA Sbjct: 283 DIAGKNIANPVASILSCIMMLKHLNQTET-----AGIMEKSVENVIRNGTIPIESGGNAG 337 Query: 348 TPQVADAI 355 T + + + Sbjct: 338 THEFINKV 345 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 275 bits (704), Expect = 1e-72, Method: Composition-based stats. Identities = 92/367 (25%), Positives = 161/367 (43%), Gaps = 34/367 (9%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWAS--CEYYSHHGKMMPDDWH 63 ++ +PGDGIG ++ + V + ++ E + E + K +P Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAVL 98 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 E D + G P +L + RR+ Y +RP+R+ Sbjct: 99 EACKACDILVKGPFVTPRAGDRWPNLLSANSLLRRQLQLYAAVRPIRIPE---------- 148 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPR 183 ID+ REN EGEY + G ++ I + ++ G +R+ R AFE A+S + Sbjct: 149 -KGIDWTFFRENIEGEY--IWGNKGICVGDDLAIDFKILSKPGAERLFRNAFEYAKSSGK 205 Query: 184 KTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE---RFDVV 240 +T ATK+N + + + + AM + YP I ++ ID L A+ + PE V Sbjct: 206 TNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DPEFNAGMQVF 264 Query: 241 VASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI---ANP 297 V NL+GDIL+D+ G +G A S+N+ + ++FE +HG + N A+P Sbjct: 265 VLPNLYGDILTDIAAEYQGGLGTASSSNIGDQY---AMFEAIHGVGVYLVEHNRAQYADP 321 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIE---EVIAHGPKTPDMKGNATTPQVADA 354 + I A M+ F+G ++R + + A++ +V T D G AT + A+ Sbjct: 322 SSLIRAMGEMMAFIGYPEKR-----DRLFKALDFCTKVERKAVITTDKDG-ATAEEFAEY 375 Query: 355 ICKIILR 361 + + + + Sbjct: 376 VVETLHK 382 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 272 bits (697), Expect = 9e-72, Method: Composition-based stats. Identities = 95/367 (25%), Positives = 154/367 (41%), Gaps = 17/367 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + IA IPGDG+G E+ E + L+ A E +G + F + A +P + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEA-IAGTAALDRGQCPLPRE 69 Query: 62 WHEQLSRFDAIYFG--AVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--C 117 + D+I G AVG + L R ++RP + C Sbjct: 70 SLKTCLEADSILMGKLAVGRHPGLKFEERPESILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 118 PLAGK-QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL + + +D ++R+ G ++ G+ + + + R AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFT-TEGKSSNLCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 177 LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPER 236 LA SR RK +TS K+ L S W + +E +YPEI + +D + V P+ Sbjct: 189 LAASRKRK-VTSLDKA-ILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDA 246 Query: 237 FDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN 296 FDV+VASN+FGDI++D TG P+ +LN ER +H ++ G AN Sbjct: 247 FDVIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRAN 306 Query: 297 PIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPD--MKG--NATTPQVA 352 P+ I A AMML++ + G+ A+ V+ G G A T + Sbjct: 307 PVGMILAAAMMLEY----SFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIG 362 Query: 353 DAICKII 359 +A+ + + Sbjct: 363 EAVRECL 369 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 272 bits (695), Expect = 2e-71, Method: Composition-based stats. Identities = 77/359 (21%), Positives = 161/359 (44%), Gaps = 37/359 (10%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 KT ++ I G+G+G+E++ V+ A + ++ + E+ + + + Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEV 136 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + L G V + R++F Q+ + G+ P Sbjct: 137 LKSLRANKVGIKGPVDSRHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY--- 183 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 GD D ++R+ EG+YS + V G V+ V T G RI + F A Sbjct: 184 --GDFDVVIIRDQMEGDYSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNK 237 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVV 241 RK +T A K+N + ++ + E + A A+ + ++ ++++++D + +++P + DV+V Sbjct: 238 RKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMV 297 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 +S+++GD+L + G GI P +++ + ++F+ + + GK++ANP + Sbjct: 298 SSSMYGDVLRVIAGGMMGVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANPTGPL 354 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + A+ML + + + + + AI +V +TPD+ G A + A+C + Sbjct: 355 LSAALMLRHV-----KMDKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 408 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 271 bits (692), Expect = 4e-71, Method: Composition-based stats. Identities = 118/376 (31%), Positives = 177/376 (47%), Gaps = 29/376 (7%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSHHGKMMPD 60 MK IA IP DG+GK+V+P G + +Q A E GF L E A EY GKM D Sbjct: 1 MKKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYE-AGVEYAVKTGKMCED 59 Query: 61 DWHEQLSRFDAIYFGAVGWPD------TVPDHISLWGSLLKFRREFDQYVNLRPVRLFPG 114 + E +++ DA+ G+ G D P + + L R + LRP+RL G Sbjct: 60 NLGEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 + CPL + +ID +VR+ EG Y G + + V TR ++ Sbjct: 120 IDCPLRNR--EEIDVLLVRQLAEGFYIRPGHMI----GEDAAYDTIVVTRNVTEKFADTC 173 Query: 175 FELAQSR------PRKTLTSATK-SNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 F LA+ R +K +T K N ++ + ++ YP+I +D L Sbjct: 174 FRLARGRHGRRQDGKKMVTLGNKHGNV--TCFDFYRKIFTEVSAGYPDIGLQFTQVDALA 231 Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 + P+RFDV+ N+ GDI+ D+G TG +GI P+A++ F P HG+ P Sbjct: 232 EHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVG---GVTPQFRPNHGTFP 288 Query: 288 DIYGKNIANPIATIWAGAMMLDFLGN--GDERFQQAHNGILAAIEEVIAH-GPKTPDMKG 344 GK ANP+A+I ++LD LGN GD+ ++ I A+E + GP+T D+ G Sbjct: 289 RAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGG 348 Query: 345 NATTPQVADAICKIIL 360 A T A+A+ K + Sbjct: 349 TANTFATAEAVFKAME 364 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 150/359 (41%), Gaps = 21/359 (5%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 + +PG+G+G EV+ + +L+ E G + G+ + + Sbjct: 30 VGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV---- 85 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP--CPLAGKQP 124 F A F G P + RR FD Y L P+R +P + L + Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRF---VYDLRRHFDLYCKLIPLRHWPALADAGVLRPEAA 142 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRK 184 D +VREN G Y G EG Q + V+RILR A LA R R Sbjct: 143 RSADVLIVRENASGLYCGEWGSEGEGA-ARSAYQVCRYRADEVERILRTALRLAGQR-RG 200 Query: 185 TLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASN 244 L TK G+ W + + A+A + +R +D + + P +FDV+V N Sbjct: 201 DLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQFDVIVCPN 260 Query: 245 LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAG 304 +FGDIL D G G+ G++ S N ++++ HG+A D+ G++ ANPI + + Sbjct: 261 MFGDILGDCGSLLMGSRGMSWSGNYGA--AGQAVYQTAHGAAWDLAGRDRANPIGQVCSL 318 Query: 305 AMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG----NATTPQVADAICKII 359 AMML R + + AI +A G +T D++G T + A+C + Sbjct: 319 AMMLR----ESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQALCASL 373 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 266 bits (680), Expect = 8e-70, Method: Composition-based stats. Identities = 113/372 (30%), Positives = 161/372 (43%), Gaps = 72/372 (19%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 ++T+RI IPGDGIGKEV+P G R+L+A G F + A E + G +PD Sbjct: 3 IRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLH-AGFETFERTGAALPDK 61 Query: 62 WHEQLS-RFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 E L D FGAV P + S ++ R++ D Y N+RPV+ P Sbjct: 62 TVEILRNECDGALFGAVSSPSSPVKGYS--SPIVALRKKLDLYANVRPVKTVLSAAKP-- 117 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 ID +VRENTE Y + V + R RI A ++A Sbjct: 118 ------IDMVIVRENTEDLYVKEETTRDTPDGK-VAEAIKRISERASHRIATMAGDIALR 170 Query: 181 RPRKT------------LTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 R + +T KSN L + Sbjct: 171 RQKIRAAGAPSIHQSPLVTITHKSNVL-----LRLK------------------------ 201 Query: 229 RFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPD 288 +V+V NL+GDILSD A G++G+ PSAN+ ++ EP HGSAPD Sbjct: 202 ---------NVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE---GFAIGEPCHGSAPD 249 Query: 289 IYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNAT 347 I G+NIANPIAT+ + A+ML+FL + AA++ + G +PD+ G A Sbjct: 250 IMGQNIANPIATLRSAALMLEFLDEEAAAAKIY-----AAVDANLTEGKLLSPDLGGTAK 304 Query: 348 TPQVADAICKII 359 T +V + I + + Sbjct: 305 TTEVIEDILRRL 316 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 264 bits (676), Expect = 3e-69, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 112/258 (43%), Gaps = 31/258 (12%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 R+ I GDG G E+ RVL+A G A ++ + A + G +PD E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA----TGVAFDWDIQD-AGVDVMEQLGTPLPDSVLE 57 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 + + P + R+E D Y +RP R +PGV + Sbjct: 58 SIRSTKVALKAPITT----PVGTGFRSVNVAIRKELDLYACVRPCRSYPGVRS-----RF 108 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEV-----------------VIQESVFTRRGV 167 +ID VVRENTE Y+ + E+ I + G Sbjct: 109 ENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPMSVPGS 168 Query: 168 DRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILC 227 +RI+R+AFE A++ RK +T+ K+N + S + E +A+ YP+I +D + +D +C Sbjct: 169 ERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRIVDNMC 228 Query: 228 ARFVMQPERFDVVVASNL 245 + V +PE +DV+V NL Sbjct: 229 MQLVQKPELYDVMVLPNL 246 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 260 bits (665), Expect = 6e-68, Method: Composition-based stats. Identities = 103/367 (28%), Positives = 141/367 (38%), Gaps = 43/367 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFE-QMEWASCEYYSHHGKMMPD 60 M T I GD G EV+ E ++VL+A F Q H + Sbjct: 1 MATHNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTA 60 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHI-SLWGSLLKFRREFDQYVNLRPVRLFPGV---P 116 DAI GA+G P+ P LL+ R+E Y NLRP Sbjct: 61 KALAAAKAADAILLGAIGGPEWGPSSPVRPEEGLLRLRKELGTYGNLRPCNFASDSLVDS 120 Query: 117 CPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 PL DF VVRE T G Y E + ++R ++RI R A Sbjct: 121 SPLKADVCRGTDFIVVRELTGGIYFGA---RTEDDGSGFAMDTDAYSRAEIERIARLAGF 177 Query: 177 LAQ-SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPE 235 LA + P + S K+N LA S + E A +P++ Q ID V P Sbjct: 178 LALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSPR 237 Query: 236 RFD-VVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNI 294 + VVV SNLFGDI+SD G+IG I Sbjct: 238 ALNGVVVTSNLFGDIISDEASVIPGSIGA-----------------------------GI 268 Query: 295 ANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NPI TI + AMML + N + + A + +G +T D+ G+A T Q+ADA Sbjct: 269 VNPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTA----LDNGTRTKDLGGSAGTFQMADA 324 Query: 355 ICKIILR 361 + +++ Sbjct: 325 VVVELVK 331 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 94/360 (26%), Positives = 145/360 (40%), Gaps = 30/360 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M I + GDGI +E+ V A F + F ++ S E G + D+ Sbjct: 6 MNRYSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDL-SDESREAKGDAIYDE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + R+ P + R + V RPV PG+ Sbjct: 61 AEAAMRRYGTSLK--------YPTATTKESPNRVLRERCNFAVIHRPVATIPGIQTHYN- 111 Query: 122 KQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 I +VR T G Y G R+N + + RR R+AF LAQ R Sbjct: 112 ---ERIHLDIVRIATGGTYEDAGRRINR----DTAVSIRAIERRPSVLASRFAFRLAQLR 164 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 + + +K + + E +A +YP + ++ D L A +M+PER+ V+V Sbjct: 165 D-SNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYGVIV 223 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTF---PSLFEPVHGSAPDIYGKNIANPI 298 N +GD LSD+ G+IG+ SA+ + + ++F+P G+APDI G+N ANP Sbjct: 224 CPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKANPT 283 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A + A A ML +G D + A+ I G KT D+ G+ + I Sbjct: 284 AALLAMANMLRHIGEHDS-----SKALRGALFGAIEAGEKTADIGGSLNLSEFTQVIVDR 338 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 125/337 (37%), Positives = 169/337 (50%), Gaps = 52/337 (15%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +IAAI GDGIG EV+ G + A ++ W + S Sbjct: 16 YKIAAIRGDGIGPEVIEAG---------NYQSAEETNRVAWILLNWPSRT---------- 56 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLR------PVRLFPGVPCP 118 GAV D + S + F Y+ LR P R+F G+ P Sbjct: 57 --------LSGAVRITRNTADISPISSSTFLW---FSSYLPLRSSTSNMPTRVFHGIQSP 105 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 L +D+ +VREN+EGEY+ GGR G EV S+FTR GV+RI+++AFE A Sbjct: 106 L------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEAA 159 Query: 179 QSRPRKTLTSATKSNGLAISMPYWDERVE-AMAENYPEIRWDKQHIDILCARFVMQPERF 237 +SR +K +T ATKSN + WDE +A +P++ DK +D + AR V+ PE Sbjct: 160 RSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPESL 219 Query: 238 DVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANP 297 D +V +NL ILSDL A G+IGIAP++NL+P R PS+FEPVHGSA DI GK++A Sbjct: 220 DTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA-- 277 Query: 298 IATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIA 334 T W A ML +LG A +L +E V Sbjct: 278 --TFWTVAEMLSWLGQKG-----AAAELLECVESVCK 307 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 256 bits (654), Expect = 1e-66, Method: Composition-based stats. Identities = 91/457 (19%), Positives = 152/457 (33%), Gaps = 119/457 (26%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEW-ASCEYYSHHGKM--MPDDW 62 + I GDG G ++ P +VL AA + + + A E +G +P D Sbjct: 29 VPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQYLPQDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + P + + R+ FD Y +RP R + G P P Sbjct: 89 LTAIKEYGIAIKGPLTTPI----GGGIRSLNVALRQIFDLYACVRPCRYYAGTPSPHKS- 143 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + + I Sbjct: 144 -PDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHGKKQIPLDAGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA------ 210 +R G R++R A + A P++ +T K N + + + + +A Sbjct: 203 IKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDWGYELATQEFRA 262 Query: 211 --------------ENYPEIRWDK--QHIDILC--------ARFVMQPERF--------- 237 E P+I ++ + ID A+ V + E Sbjct: 263 ECVTERESWILGNKEKNPQISLEENARMIDPGFDNLTPEKKAQIVKEVETVINSIWSTHG 322 Query: 238 ------DVVVASNLFGDILSDL-----------------------GPACTGTIGIAPSAN 268 V+V + I + A G +G+ P AN Sbjct: 323 DGQWKDKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGAN 382 Query: 269 LNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAA 328 + ++FE HG+AP G + NP + I +G MML+++G +Q+A + I Sbjct: 383 IGDS---CAIFEATHGTAPKHAGLDKINPGSVILSGVMMLEYMG-----WQEAADLIKRG 434 Query: 329 IEEVIAHGPKTPDMKG-------NATTPQVADAICKI 358 + IA G T D+ + AD I + Sbjct: 435 LGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 255 bits (652), Expect = 2e-66, Method: Composition-based stats. Identities = 110/346 (31%), Positives = 171/346 (49%), Gaps = 47/346 (13%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 +A IPGDGIG+E++P AAA ++F + S E Y G ++ DD E+L Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDI-SSERYIKTGIIIKDDELEEL 57 Query: 67 SRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGD 126 + AI FGA+G P P I G +L+ RRE + Y+N+RPVR F Sbjct: 58 KNYRAILFGAIGDPRVRP-GIMEQGVILRLRRELELYMNIRPVRSFD-----------DK 105 Query: 127 IDFYVVRENTEGEYSSLGG---------------RVNEGTEHEVVIQESVFTRRGVDRIL 171 I ++RENT+ Y+ + G ++ + EV + + R + + Sbjct: 106 IKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFF 165 Query: 172 RYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFV 231 AF + T+T K+N + + W A I ++ D L + Sbjct: 166 NKAFSIC----DSTVTVTDKANAVKMYN-LWRSTAMEAAIE-KNINISFEYADALAYNMI 219 Query: 232 MQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYG 291 + P+++ ++A NL+GDI+SD+G A G +G APSAN+ + +LFEPVHGSAPDI G Sbjct: 220 LNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDK---NALFEPVHGSAPDIAG 276 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP 337 +++ANP A+I AG+M+L++LG DE I + + +G Sbjct: 277 RDMANPAASIMAGSMLLEYLGYRDE-----SRIINDMVRNLYINGV 317 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 255 bits (651), Expect = 2e-66, Method: Composition-based stats. Identities = 92/362 (25%), Positives = 147/362 (40%), Gaps = 17/362 (4%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 T I + GD G+E+L + +RVLQ + R L F + S E + + Sbjct: 4 TTPTIVVMHGDQTGEELLIQALRVLQPSVIR--QPLQFLDYDL-SLENRRATDNKVVWEA 60 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + A P+ D R + V LR R P + P+AG Sbjct: 61 AQAARDSGLSLKAATITPEIAGDVG---SPNAILREALNAKVILRTGRRIPKI-RPIAGV 116 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 +VR + Y S R E+ + S +R + + F+ A R Sbjct: 117 YSP---IAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFTFQYA-KRT 172 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 + + K A + E ++A A+ YPE+ + ID A + V+ A Sbjct: 173 KAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTGESLVIPA 232 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPI 298 N GD+LSD+ G+I + S L ++ + E HG+AP ++GKNIANP+ Sbjct: 233 LNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPM 292 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKI 358 A I AGA +L + + ++A I ++ E I G TPD+ G TT + D + + Sbjct: 293 AMILAGAALLSY--GRIPQAEKASRAIYESVFETIYEGKATPDLGGQMTTSEFTDEVIRR 350 Query: 359 IL 360 + Sbjct: 351 VE 352 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 251 bits (641), Expect = 3e-65, Method: Composition-based stats. Identities = 78/370 (21%), Positives = 145/370 (39%), Gaps = 34/370 (9%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + +R+ I G G G VL ++ +AA + ++ + + + + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAAL----VPVEWDYQTLSVYRDHKTNRMTVNPQL 94 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + P SL L + + +V +R G + Sbjct: 95 LDSAIETGLVLCAKDSSPRQND---SLESDSLALHKALNAFVGVRKFNSVVG------HE 145 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 G I+ +RE+ GEYS + V+ G VV +++ + + AF+ A Sbjct: 146 PYGPINLVNIREHVSGEYSEIEHLVSPG----VVQSIKTVSKKISVEVAKLAFDYACKHG 201 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 +T K++ + +S + + ++ YP++ ++++ +D C P R++V++ Sbjct: 202 HSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRYEVLLT 261 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEP------VHGSAPDIYGK---- 292 ++L+G + +G + P+ P+ T S H I+ K Sbjct: 262 TSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFKKMVYG 321 Query: 293 --NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 I NP I A A+MLD G A I AA+E+ I G +T DM G+A+ Q Sbjct: 322 QEQIINPTGIIRAAALMLDHAG-----MVVAGRCIAAAVEDTIRQGIRTQDMGGDASCSQ 376 Query: 351 VADAICKIIL 360 DAI K + Sbjct: 377 FTDAIIKNLK 386 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 246 bits (629), Expect = 8e-64, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 148/342 (43%), Gaps = 37/342 (10%) Query: 20 LPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGW 79 + V+ A + ++ + E+ + + + + L G V Sbjct: 1 MDAVQEVICAVKA----PIEWDVHD----EFKAKDSDDVSPEVLKSLRANKVGIKGPVDS 52 Query: 80 PDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE 139 + R++F Q+ + G+ P GD D ++R+ EG+ Sbjct: 53 RHWQ----------RQIRKQFAQFAYVSLCSHIEGLDSPY-----GDFDVVIIRDQMEGD 97 Query: 140 YSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 YS + V G V+ V T G RI + F A RK +T A K+N + ++ Sbjct: 98 YSGIEHLVVPG----VMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANIMRMTD 153 Query: 200 PYWDERVEAMAENY-PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACT 258 + E + A A+ + ++ ++++++D + +++P + DV+V+S+++GD+L + Sbjct: 154 GNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMM 213 Query: 259 GTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERF 318 G GI P +++ + ++F+ + + GK++ANP + + A+ML + + Sbjct: 214 GVPGICPGYSVS---SLGTVFDCRMKACHALAGKDLANPTGPLLSAALMLRHV-----KM 265 Query: 319 QQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKII 359 + + + AI +V +TPD+ G A + A+C + Sbjct: 266 DKQADQVDCAIRKVYKDTDIRTPDVGGKAKCSEFVKAVCDCL 307 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 243 bits (620), Expect = 8e-63, Method: Composition-based stats. Identities = 77/327 (23%), Positives = 143/327 (43%), Gaps = 35/327 (10%) Query: 19 VLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVG 78 ++ ++V + ++ + S G+ + E L R G Sbjct: 1 MIESLVKVFSTVQ----VPIDWDVFH--EHKINSAEGEDVSPKLLESLCRNKIGIKGPFE 54 Query: 79 WPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEG 138 L K R++F + + R G + G +D ++R+ EG Sbjct: 55 SGPC----------LRKLRKKFQLFAFVAVCRNLEG-----QNTRYGKLDCLIIRDQVEG 99 Query: 139 EYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAIS 198 EYS + RV G V+ V T G DR+ RY FE A+ RK +T A K+N + ++ Sbjct: 100 EYSGIEHRVVPG----VMQTIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKANIMRLT 155 Query: 199 MPYWDERVEAMAENYP-EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPAC 257 + + A Y +I ++++++D +C +M+PER DV+VAS+++GD+L+ + + Sbjct: 156 DGTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASI 215 Query: 258 TGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDER 317 G + P + P ++EP+ + +I GK+I NP + +G +ML + + Sbjct: 216 MGGPALCPGFAVGPMGL---IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLR-----EMK 267 Query: 318 FQQAHNGILAAIEEVIAH-GPKTPDMK 343 + + I A+ V +T D+ Sbjct: 268 LNEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 242 bits (617), Expect = 2e-62, Method: Composition-based stats. Identities = 100/365 (27%), Positives = 152/365 (41%), Gaps = 17/365 (4%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + ++I + GD G+E+L + +RVL E G L E+ + S E + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDL-SLENRRATQNGVVS 57 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D + A P+ D R E D V +R R PGV P+A Sbjct: 58 DAAAAMRTCGFGIKAATITPEGADDVG---SPNRILREEVDGKVIVRTGRRIPGV-TPIA 113 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNE-GTEHEVVIQESVFTRRGVDRILRYAFELAQ 179 G +VR E Y + R + G EV + TR + YAF A+ Sbjct: 114 GVHYP---ISIVRMAIEDAYGAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEYAFRTAR 170 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QPERFD 238 + + K + E ++A A +P++ ++ ID A V + Sbjct: 171 AMQ-ARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGAADEPL 229 Query: 239 VVVASNLFGDILSDLGPACTGTIGIAPSANL---NPERTFPSLFEPVHGSAPDIYGKNIA 295 VV A N GD LSDL G+I A S L + T ++ E HG+AP + GK++A Sbjct: 230 VVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALRGKDVA 289 Query: 296 NPIATIWAGAMMLDFLGNG-DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADA 354 NP+A + A +L ++A I ++ E IA G KTPD+ G+A T + DA Sbjct: 290 NPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDLGGHAGTTEFTDA 349 Query: 355 ICKII 359 + + I Sbjct: 350 VIERI 354 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 236 bits (602), Expect = 1e-60, Method: Composition-based stats. Identities = 75/355 (21%), Positives = 130/355 (36%), Gaps = 23/355 (6%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAE-RWGFALSFEQMEWASCEYYSHHGKMMPDD 61 + ++A +PGDG G + R L R + + ++ + G +P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV---PCP 118 + DA+ G P I LL R+E + VN+RPVR Sbjct: 68 TLGACRQSDAVLVCGCGDPRY---GIEPERGLLTLRQELEGCVNIRPVRFPSSQLVQQSS 124 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELA 178 + +D R+ T G Y + E + ++R+ ++RI R A A Sbjct: 125 YKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGE---AYDTTPYSRQTIERIARLAGTYA 181 Query: 179 QS-RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 P K + S K N +A S + +P++ +D P Sbjct: 182 MQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDPLSL 241 Query: 238 D-VVVASNLFGDILSDLGPACTGTIGIAPSANL-----NPERTFPSLFEPVHGSAPDIYG 291 + +++ N+FGDILSD G+ + SA + R P +FEP + + G Sbjct: 242 NGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLNP----G 297 Query: 292 KNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIE--EVIAHGPKTPDMKG 344 P+ +I A +ML+ + I ++ E++ +T D+ G Sbjct: 298 GKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 230 bits (588), Expect = 5e-59, Method: Composition-based stats. Identities = 76/342 (22%), Positives = 145/342 (42%), Gaps = 45/342 (13%) Query: 18 EVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAV 77 E+ + LQ A G ++++ ++ ++P+ + + G + Sbjct: 12 ELGAQVTNALQMAIAATGVDITWQIVDIGG----EDQQGLLPNYIFDIIRTAKTAVIGPL 67 Query: 78 GWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTE 137 PD + R + D YVNLRP + G+P ++D +VRE TE Sbjct: 68 MMPD------NYRQMEADIREKLDLYVNLRPAKTMVGIPSNY-----QNVDIMIVRETTE 116 Query: 138 GEYSSLGGR----------------VNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSR 181 G Y+ + + + + + +G +I+ +AF A+ Sbjct: 117 GIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQIIEFAFNYARKT 176 Query: 182 PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVV 241 R + + +++ +A + + E +A+ +P+I + + I+++C + +PERFDV+V Sbjct: 177 KRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQELMQKPERFDVLV 236 Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATI 301 NL+GD+L+ L G + + P A++ + + D G + P + I Sbjct: 237 MPNLYGDLLAHLCAGMVGGLSV-PIAHVGDKYAVFG----AQSTGTDDVGHD---PTSLI 288 Query: 302 WAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDM 342 AGA+ML LG Q+A + AA+E V+A T D+ Sbjct: 289 LAGALMLRHLGE-----QEAAQRLQAAVEAVVASHVDTTADL 325 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 97/364 (26%), Positives = 146/364 (40%), Gaps = 31/364 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 +R+A +PGDG+G+EVL R+L+ AER ++ + G ++P Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVTGPWP--VGARAAAETGDVLPAGTLA 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDH--ISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 DAI GAVG VP +L + R +D +++R + G Sbjct: 60 ACDAADAILLGAVGEDPRVPAGVCPRPEVALHRLRERYDLRISVREIPFADGRE------ 113 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 VVR G Y RV E TR V ++ A ++ R Sbjct: 114 ------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLGRRG 166 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 L S K+N L + W + +A I + +++D DV+V Sbjct: 167 GGRLVSVDKAN-LYATGRLWRQVAGDVARE-RGIEVEHRYVDRAAFELGSGAPVPDVLVT 224 Query: 243 SNLFGDILSDLGPACTGTIGIAPSANLNP----ERTFPSLFEPVHGSAPDIYGKNIANPI 298 L GDILSDL G+ + SA+L+P LFEP HGSAP ++ +P+ Sbjct: 225 EGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDPL 284 Query: 299 ATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM----KGNATTPQVADA 354 A A +L ++A + AA+ V+ GP T D+ A+T QVADA Sbjct: 285 GGFLALAALLRHF----PATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVADA 340 Query: 355 ICKI 358 + Sbjct: 341 VLAA 344 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 229 bits (584), Expect = 1e-58, Method: Composition-based stats. Identities = 106/351 (30%), Positives = 159/351 (45%), Gaps = 21/351 (5%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 +T R+ G+GIG E++ ++ ++ A + G A E + G+++P++ Sbjct: 5 ETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEET 64 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 E ++ D G P R++ D + N+RPVR PG P Sbjct: 65 WETITGLDGWILGPHDNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP---- 120 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT---EHEVVIQESVFTRRGVDRILRYAFELAQ 179 D+D +VRENTEG Y+ + G EV + VFT+ + + Sbjct: 121 ---DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIR-RIVRRAAAIA 176 Query: 180 SRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 + LT A KSN L + + +A AE + + HID LCA V +PER+ Sbjct: 177 AARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTRPERYAT 235 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 +VA N+FGDILSDL G++GIA S N + + + + HGSAPDI G+ IANP Sbjct: 236 IVAENMFGDILSDLAGGLGGSLGIAGSINASESQ---VMAQAAHGSAPDIAGQGIANPAG 292 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQ 350 + + A MLD LG QA + A+ E + P T D+ A Sbjct: 293 IMNSAAQMLDSLGY-----PQAAELLEGAVREAVVKAP-TADLVREAAAAD 337 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 211 bits (537), Expect = 3e-53, Method: Composition-based stats. Identities = 91/255 (35%), Positives = 126/255 (49%), Gaps = 19/255 (7%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 IA IPGDGIG E++ + VL+AAA R L F + A + + G M E++ Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSED-AGADAFRRTGSAMSAATLERI 66 Query: 67 S-RFDAIYFGAVGWPDTV-PDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQP 124 R+ + G VG P PD R D Y N+RP+ L PGV PL G Sbjct: 67 RTRYHGVLKGPVGLPGVRHPDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAPLRGTA- 125 Query: 125 GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESV-FTRRGVDRILRYAFELAQSR-- 181 +D+ +VRENTEG Y S G G ++ + + TR GV+R++ +AFELA R Sbjct: 126 --VDYVIVRENTEGLYLSRG----RGVGNDRACADQLLMTRHGVERVVVHAFELATRRTG 179 Query: 182 ----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERF 237 + +T KSN L S ++ E + +A YP++ D ++ D V P RF Sbjct: 180 APADGVRRVTCVDKSNVLR-SFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPGRF 238 Query: 238 DVVVASNLFGDILSD 252 DV+V N GDILSD Sbjct: 239 DVLVMENFLGDILSD 253 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 210 bits (536), Expect = 4e-53, Method: Composition-based stats. Identities = 68/378 (17%), Positives = 130/378 (34%), Gaps = 44/378 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERW--GFALSFEQMEWASCEYYSHHGKMMP 59 + I I GDGIG E+ I V+ +A E G E Y G +P Sbjct: 21 PDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVP 80 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPL 119 +D +++ + + +PD R+ Y N+R ++ G+ P+ Sbjct: 81 EDSIKEIQKMYIAMK---STLNFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMDIPV 134 Query: 120 AGKQPGDIDFYVVR-------------ENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRG 166 ++ ++R E+T+ + + I ++ Sbjct: 135 N--TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQSKFR 192 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDIL 226 +I + A ++ +K +T + + A ++ ++ Sbjct: 193 TRKIAKQAVRYSRRNGKKKITILE-----SQQNHEFANWCIEEASAQEDVGYEVLKTREF 247 Query: 227 CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 R + PE F+V++ N+ L D GTI I +++ E ++FE V S Sbjct: 248 MKRLISSPEDFEVILVDNVLSQTLVDYLA---GTINIEYGSSIGDE---CAVFEAVQSSL 301 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK--- 343 P G + A+P++ I +G ML +G + +A I AI D+ Sbjct: 302 PSEAGYDAADPLSFILSGCEMLMHIG-----WVEAAQIIENAISAAFRDNKIPKDINTRP 356 Query: 344 --GNATTPQVADAICKII 359 + + I K + Sbjct: 357 DISPIKCSEFSSEIIKRM 374 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 200 bits (509), Expect = 6e-50, Method: Composition-based stats. Identities = 69/361 (19%), Positives = 126/361 (34%), Gaps = 68/361 (18%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 M + + + I V +V+ A + FE + + Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQA----PVYFETYIIKG-----KNMNHLTW 44 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + + + G V R+E D + +L G P Sbjct: 45 EVVDSIRKNKVCLNGRVNNSLCGGA-----------RKELDLFASLVDCFNLNGQPS--- 90 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + ++D V+RENTEGEY+ V G + T+ DRI +YAFE A Sbjct: 91 --RHENVDIVVIRENTEGEYAGREHEVVPGVIESFQVTM---TKFWSDRIAKYAFEYAHF 145 Query: 181 RPRKTLTSATKSNGL-AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDV 239 RK +T+ + ++ ++ E + +A+ YP I +++ +R R Sbjct: 146 SKRKKVTAVHNNGKYEKLADAFFLESCQEVAKMYPNITYNEI-----ASRETRAIRRHS- 199 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 S I++++ G + + ++FE V N NP+A Sbjct: 200 --NSKSLWAIIANIASGVAGG-------SFGDDY---AIFEQVGSVG------NHKNPVA 241 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 +++ MML L + + A+ VI+ G N TT +V D++ + Sbjct: 242 LLFSSVMMLRHLL-----LPLFADRLKTAVTRVISEGKCG---NSNTTTQEVVDSVIANL 293 Query: 360 L 360 Sbjct: 294 D 294 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 196 bits (499), Expect = 9e-49, Method: Composition-based stats. Identities = 57/165 (34%), Positives = 89/165 (53%), Gaps = 9/165 (5%) Query: 196 AISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGP 255 +S + V MA+ +PEI+++++++D +C V P ++DV+V NL+GDILSD+ Sbjct: 112 RMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCA 171 Query: 256 ACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 G +G+ PS N+ +LFE VHG+APDI GK++ANP A + + MML + Sbjct: 172 GLVGGLGLTPSGNMGLNG---ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRHM---- 224 Query: 316 ERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVADAICKII 359 + I A E I G T D+ G A + + IC + Sbjct: 225 -ELNTYADKIERAAFETIKEGKYLTGDLGGRAKCSEFTNEICAKL 268 Score = 49.2 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 21/42 (50%), Gaps = 4/42 (9%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEW 45 T ++ IPGDGIG E+ ++ AA + +E ++ Sbjct: 47 TKKVTLIPGDGIGPEISAAVQKIFTAA----NVPIEWEAVDV 84 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 195 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 64/416 (15%), Positives = 120/416 (28%), Gaps = 67/416 (16%) Query: 3 KTMRIA--AIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++A + D G E+ + ++ + + + + Sbjct: 42 KRIKVAKPVVEMD--GDEMTRIIWQFIKEKLILPHVDIQLKYFDL-GLPNRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D ++ A PD R V P+ + + Sbjct: 99 DSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPI-ICKNI 157 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEY----------------------SSLGGRVNEGTEH 153 P + G + R +Y S + Sbjct: 158 PRLVPGWTKP---ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPA 214 Query: 154 EVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 V T + F+ A + L +TK+ L + + + + ++ Sbjct: 215 GGVGMGMYNTDESISGFAHSCFQYAIQ-KKWPLYMSTKNTILKAYDGRFKDIFQEIFDKH 273 Query: 213 YP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y +I ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 274 YKTDFDKNKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTS 332 Query: 267 ANLNPERTFPSLFEPVHGSAPDIY---GKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K NPIA+I+A L+ G D + Sbjct: 333 VLVCPDGKTI-EAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDL 391 Query: 319 QQAHNGILAAIEEVIAHGPKTPDMKGN-------------ATTPQVADAICKIILR 361 + + E + G T D+ G T D I + R Sbjct: 392 IRFAQMLEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDR 447 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 66/418 (15%), Positives = 128/418 (30%), Gaps = 70/418 (16%) Query: 1 MMKTMR---IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M K + + + GD E+ +++ L + E Sbjct: 1 MSKKISGGSVVEMQGD----EMTRIIWELIKEKLIFPYVELDLHSYDL-GIENRDATNDQ 55 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLF 112 + D E + + + A PD R V R + Sbjct: 56 VTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVF-REAIIC 114 Query: 113 PGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRR------- 165 +P ++G + R +Y + V + E+ S T++ Sbjct: 115 KNIPRLVSGWVKP---IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHN 171 Query: 166 ----------------GVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 ++ +F++A S+ L +TK+ L + + + + Sbjct: 172 FEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKG-WPLYLSTKNTILKKYDGRFKDIFQEI 230 Query: 210 -AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 + Y +I ++ + ID + A+ + F + N GD+ SD G++G Sbjct: 231 YDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSLG 289 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ + NPIA+I+A L D Sbjct: 290 MMTSVLVCPDGK-TVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDN 348 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMKG------------NATTPQVADAICKIIL 360 + N + E I G T D+ T + D + + + Sbjct: 349 NKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLK 406 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 55/301 (18%), Positives = 111/301 (36%), Gaps = 19/301 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 D E ++++ +K + D Y+ VR FPG Sbjct: 93 DPLETDDFYNSVLRNRSAVHVENVVDAEAKKKSMKLCNDLDLYMFKCRVRSFPGF----- 147 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + D++ ++ +N G YS L +G VV SV T+ G ++ LR AF A Sbjct: 148 NCRFPDVNIRIIAQNNMGVYSDLEYSPVKG----VVEAISVSTQEGNEKYLRKAFATAVK 203 Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDV 239 RK +T KS I+ + + ++Y + + +++ R + P+ FD Sbjct: 204 ANRKRVTLIHKSTEWPITDGAMVSAAKEIHKDYEHCLELELMNVEDCIGRLITHPQEFDC 263 Query: 240 VVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIA 299 + +S+ + +++ + G + + + ++F+P+ + I +P Sbjct: 264 IFSSDRYATMIATMCSGICGGANLFSAVEIGDFH---AVFKPLQ-VKLSLTNYPILSPYG 319 Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 + + D LG + + + + + G KT D G + V I + Sbjct: 320 IVNTIVDLFDHLGYT-----ECGDALWEQMLRTMESGIKTKDFGGEDSGEYVICNIINRL 374 Query: 360 L 360 Sbjct: 375 R 375 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 189 bits (481), Expect = 1e-46, Method: Composition-based stats. Identities = 67/414 (16%), Positives = 132/414 (31%), Gaps = 65/414 (15%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 + +++ + D G E+ +++ + + S ++ + Sbjct: 180 QRIKVDQPVVEMD--GDEMARVIWAMIKEKLILPYLDIPLMYYDL-SIQHRDKTDDQVTI 236 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 D + R A PD R D + P+ L V Sbjct: 237 DAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPI-LMKNV 295 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE---------------HEV----- 155 P + + R +Y +L V++ HEV Sbjct: 296 PRLVPSWTKP---IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKG 352 Query: 156 -VIQESVF-TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AEN 212 + ++ T + F+ A + + L +TK+ L + + + + + Sbjct: 353 GGVALGMYNTDASIKGFAHSCFQYALDQ-KMPLYLSTKNTVLKKYDGRFKDIFQTIYEKE 411 Query: 213 YPE------IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPS 266 Y + + ++ + ID + A+ + F V N GD+ SD+ G++G+ S Sbjct: 412 YKQKFEEAGLWYEHRLIDDMVAQAIKSSGGF-VWACKNYDGDVQSDVVAQGYGSLGLMTS 470 Query: 267 ANLNPERTFPSLFEPVHGSAPDI---YGKNI---ANPIATIWAGAMMLDFLGNGD--ERF 318 + P+ E HG+ Y K I NPIA+I+A L D ++ Sbjct: 471 VLVCPDGKTI-EAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKL 529 Query: 319 QQAHNGILAAIEEVIAHGPKTPDM-----KGNAT------TPQVADAICKIILR 361 ++ + A E + G T D+ T T D + ++ R Sbjct: 530 KEFVEALEDACVETVEAGFMTKDLALAIKGDKLTDRDYLCTEDFMDKLARVAER 583 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 185 bits (471), Expect = 2e-45, Method: Composition-based stats. Identities = 68/418 (16%), Positives = 123/418 (29%), Gaps = 69/418 (16%) Query: 2 MKTMRIAA----IPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKM 57 M +I + D G E+ + ++ L + + Sbjct: 1 MAFQKITVQNPIVEMD--GDEMTRVIWKSIKDKLILPFLELDIKYFSL-GLPHRDATDDK 57 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPV--- 109 + + E +++ A PD R + V P+ Sbjct: 58 VTVESAEATQKYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCK 117 Query: 110 ---RLFPGVPCPLAGKQP----------------GDIDFYVVRENTEGEYSSLGGRVNEG 150 RL PG P+ + G + V E + E + G Sbjct: 118 NIPRLVPGWTKPICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGS-DEKTEFEVYNFTG 176 Query: 151 TEHEVVIQESVFTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM 209 + S++ R + +A + L +TK+ L + + + + Sbjct: 177 AG---GVALSMYNTDESVRSFAEASMNMAFQ-KKWPLYLSTKNTILKKYDGRFKDIFQEV 232 Query: 210 AE-------NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIG 262 E I ++ + ID + A + + V N GD+ SD G++G Sbjct: 233 YEANWKSKYEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLG 291 Query: 263 IAPSANLNPERTFPSLFEPVHGSAPDIY------GKNIANPIATIWAGAMMLDFLGNGD- 315 + S + P+ E HG+ Y G+ N IA+I+A L D Sbjct: 292 LMTSVLVCPDGKTI-EAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDN 350 Query: 316 -ERFQQAHNGILAAIEEVIAHGPKTPDMK-----GN-------ATTPQVADAICKIIL 360 ER + AA + G T D+ G+ T + DA+ + Sbjct: 351 NERLLDFTEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELK 408 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats. Identities = 75/372 (20%), Positives = 139/372 (37%), Gaps = 36/372 (9%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS----HHGKM 57 M ++++ G+G G E+ RV+Q+ A R+ +++F + Y S + Sbjct: 1 MSSIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDADA 60 Query: 58 MPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPC 117 + ++ + + AV S+ L RE Q + + L P Sbjct: 61 VTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQALYLVREQLQAIKVEHFTLSPTSS- 119 Query: 118 PLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 +VR+ +G YS + T + V + + F++ RIL YA Sbjct: 120 -----------ILLVRDQAQGFYSG---TNSVNTSKDAVSRTAHFSKAIFARILSYALGR 165 Query: 178 AQSR--PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM-QP 234 A ++T K + + + + D + + Sbjct: 166 ANQLWGGTNSVTMVYKFHLF---DGLFHTWATEWERTF-GVNIRFVQGDTMNRDLLAFGV 221 Query: 235 ERFDVVVASNLFGDILSDLGPACTGTIGIAPSA-----NLNPERTFPSLFEPVHGSAPDI 289 +++++ N + DI+ + G +G SA L+P+ S ++ HGSA D+ Sbjct: 222 SGHNLLISGNEYADIMQTILLDRFG-LGAQESACAENVYLHPDVQGLSEYQTAHGSADDL 280 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 GK I NP ATI A A +L+ + + ++ A G TPD G ATT Sbjct: 281 LGKGIVNPTATIRAAAAVLEDQAGCSG----LKQRVDCVLGDLGARGIGTPDQGGTATTE 336 Query: 350 QVADAICKIILR 361 + +A + + + Sbjct: 337 RFVEAFLQGLDQ 348 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 62/366 (16%), Positives = 115/366 (31%), Gaps = 59/366 (16%) Query: 47 SCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFD 101 EY + + E + ++ A PD R Sbjct: 101 GIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIRNILG 160 Query: 102 QYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ--- 158 V P+ + P +P + G + R +Y + + + E+V Sbjct: 161 GTVFREPI-VIPAIPRLVPGWTKP---IIIGRHAFGDQYRATDRVIPGPGKLELVYTPAN 216 Query: 159 -------------------ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISM 199 T + +F++A + L +TK+ L Sbjct: 217 GQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKG-LPLYMSTKNTILKRYD 275 Query: 200 PYWDERVEAM-AENYP------EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSD 252 + + + + Y I ++ + ID + A+ + F ++ N GD+ SD Sbjct: 276 GRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMALKNYDGDVQSD 334 Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-----GKNIA-NPIATIWAGAM 306 + G++G+ S P+ + E HG+ Y G+ + NPIA+I+A Sbjct: 335 IVAQGFGSLGLMTSTLTTPDGSAFES-EAAHGTVTRHYREHQKGRETSTNPIASIFAWTR 393 Query: 307 MLDFLGNGD--ERFQQAHNGILAAIEEVI-AHGPKTPDMK---GN------ATTPQVADA 354 L G D + A EV+ G T D+ G TT + A Sbjct: 394 GLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKEREAWVTTREYMAA 453 Query: 355 ICKIIL 360 + + + Sbjct: 454 VERRLK 459 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 61/286 (21%), Positives = 108/286 (37%), Gaps = 26/286 (9%) Query: 81 DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEY 140 D P LLK R+E Y ++RP L Q + + + Sbjct: 35 DGAPATSRPERGLLKLRKEMGTYGSMRPCFFASD---SLVAPQGRGVPRHRLCHCARAHR 91 Query: 141 SSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMP 200 L R G+ ++ V+R A L + R K L S +N LA S Sbjct: 92 RYLLWRAQTGSGS--AWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSRF 149 Query: 201 YWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFD-VVVASNLFGDILSDLGPACTG 259 + E + +P+++ + Q I+ V P + VVV S LFGDI+SD Sbjct: 150 WRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIPD 209 Query: 260 TIGIAPSANL----NPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD 315 +IG+ PSA+L + R ++EP+H + + A+ + + Sbjct: 210 SIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC----------- 256 Query: 316 ERFQQAHNGILAAIEE--VIAHGPKTPDMKGNATTPQVADAICKII 359 + + + ++ V +T ++ G A T ++ +A+ + Sbjct: 257 -PWPCFSDTLSTSLRRLWVPPWSLRTKELGGGANTKELGEAVINEV 301 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 66/386 (17%), Positives = 130/386 (33%), Gaps = 50/386 (12%) Query: 2 MKTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M +++ + D G E+ +V++ + + + EY + Sbjct: 7 MNKIKVKNPVVELD--GDEMTRIIWQVIKDKFIHPYLDIDLKYYDL-GLEYRDETNDQVT 63 Query: 60 DDWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRPVRLFPG 114 D E + ++ A PD R V P+ + P Sbjct: 64 LDAAEAIKKYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPA 122 Query: 115 VPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYA 174 +P + + + R +Y + ++ E+V + V ++ + Sbjct: 123 IPRLVPSWKQP---IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPKG-GKPEVIKVYDFP 178 Query: 175 FE--LAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 E +AQ++ K I + + EA I ++ + ID + A+ + Sbjct: 179 AEGGVAQTQF--------KDIFQEIYEAQYRKEFEA-----AGIWYEHRLIDDMVAQMIK 225 Query: 233 QPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIY-- 290 + ++ N GD+ SD+ G++G+ S + P+ E HG+ Y Sbjct: 226 SEGGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTF-EAEAAHGTVTRHYRE 283 Query: 291 ---GKNIA-NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAA-IEEVIAHGPKTPDMK 343 G+ + NPIA+I+A L G D + A ++ V G T D+ Sbjct: 284 HQKGRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLA 343 Query: 344 ---GN------ATTPQVADAICKIIL 360 G TT + DA+ + + Sbjct: 344 LAQGKKDRSAWVTTNEYLDAVERRLK 369 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 180 bits (458), Expect = 5e-44, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 106/269 (39%), Gaps = 19/269 (7%) Query: 93 LLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTE 152 LK + D YV + +R FPG C + D+D V+ +N G YS L +G Sbjct: 134 SLKICNDLDLYVFMTRLRSFPGFKC-----RFPDVDIQVIAQNNIGNYSELEYAPVKG-- 186 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-AE 211 VV V T V + LR+AFE A R +T K+N ++ E E M AE Sbjct: 187 --VVEALRVVTHENVTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMHAE 244 Query: 212 NYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNP 271 +Y I+ + +D R + P FD + ++ + L+ + G + + L Sbjct: 245 DYCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIELGD 304 Query: 272 ERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEE 331 ++F+P+ + + ++ +P + +L+ +G + + Sbjct: 305 SH---AVFKPLQ-TKLSLTNYSLLSPYGIVSTCVDLLNHVGQES-----CAKSLWKGMLR 355 Query: 332 VIAHGPKTPDMKGNATTPQVADAICKIIL 360 + G KT + G T V I + Sbjct: 356 TMTDGIKTVEFDGPDTGEYVICNIMNKLR 384 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 171 bits (433), Expect = 4e-41, Method: Composition-based stats. Identities = 68/412 (16%), Positives = 117/412 (28%), Gaps = 75/412 (18%) Query: 16 GKEVLPEGIRVL--QAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIY 73 G+E+ ++L Q + + S+E + SC+ D E R AI+ Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDIS-SWETFDL-SCKARDDSDDATLIDAVEAGKRIGAIF 146 Query: 74 FGAVGWP-----DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDID 128 P + + RR ++ R G+ + Sbjct: 147 KEPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQ------ 200 Query: 129 FYVVRENTEGEYSSLGGRVNEGT----------EHEVVIQESVFTRR------------G 166 R GEY + V EGT V+ + T + Sbjct: 201 VLFERHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPYDN 260 Query: 167 VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEI---------- 216 V + F+ TK +W + Y + Sbjct: 261 VRELAHLFFKRCLEHKVTP-YIVTKKTVFKWQEGFWATMKRVFDDTYKDEFLKAGLLDRS 319 Query: 217 --RWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERT 274 D + + + + A N GD+L+D + G S + Sbjct: 320 GGELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGVSDD 379 Query: 275 FPSL---FEPVHGSAPD-----IYGKNIA-NPIATIWA--GAMM----LDFLGNGDERFQ 319 +L FE HG+ D + GK + NP+ + A GAM L++ ++ Sbjct: 380 GTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLEYDAKPNDVEA 439 Query: 320 Q--------AHNGILAAIEEVIAHGPKTPDMKGNA--TTPQVADAICKIILR 361 + N + A+ +G T DM G TT + + R Sbjct: 440 KRMYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTGFTTEDFIAKVAWRLDR 491 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 171 bits (433), Expect = 4e-41, Method: Composition-based stats. Identities = 50/234 (21%), Positives = 81/234 (34%), Gaps = 36/234 (15%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAA-AERWGFALSFEQMEW-ASCEYYSHHGKM--MPDDW 62 I I GDG G ++ P V+ AA A+ +G + A E +G P+D Sbjct: 29 IPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQIFPEDT 88 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + G + P + + R+ FD Y +RP R +PG P P Sbjct: 89 LTAIKEYGVAIKGPLTT----PVGGGIRSLNVALRQIFDLYTCVRPCRYYPGTPSPHK-- 142 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEH------------------------EVVIQ 158 P +D V RENTE Y + + I Sbjct: 143 TPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALGKKQIRLDSGIG 202 Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKT--LTSATKSNGLAISMPYWDERVEAMA 210 ++ G R++R A A+ P+ +T K N + + + + +A Sbjct: 203 IKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDWGYELA 256 Score = 139 bits (351), Expect = 1e-31, Method: Composition-based stats. Identities = 44/170 (25%), Positives = 72/170 (42%), Gaps = 26/170 (15%) Query: 197 ISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 W E ++ + + D + + +P+ + ++ NL GD LSD A Sbjct: 321 HGNGQWKE----------KVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAA 370 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDE 316 G +G+ P AN+ ++FE HG+AP G + NP + I +G MML+F+G Sbjct: 371 VVGGLGMGPGANIGDS---AAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEFMG---- 423 Query: 317 RFQQAHNGILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKI 358 +Q+A + I I IA+ T D+ + A AI Sbjct: 424 -WQEAADLIKKGIGAAIANREVTYDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 170 bits (431), Expect = 7e-41, Method: Composition-based stats. Identities = 64/400 (16%), Positives = 116/400 (29%), Gaps = 64/400 (16%) Query: 16 GKEVLPEGIRVLQAA-AERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQLSRFDAIYF 74 G+E+ + +++A E ++ + + + +++ D E AI+ Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTAWREFDLRAKNRDDTEDQVLRD-VIEAGKAVKAIFK 76 Query: 75 GAVGWP-----DTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDF 129 P + S RR ++ R GV + Sbjct: 77 EPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGYKKPVFFE--- 133 Query: 130 YVVRENTEGEYSSLGGRVNEGT-------------EHEVVIQESVFTRRG---------- 166 R GEY++ V +GT V + T Sbjct: 134 ---RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHNPY 190 Query: 167 --VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYP---------- 214 V + R+ F TK P+W + E Y Sbjct: 191 DNVHELARFFFGRCLEAKITP-YVVTKKTVFKWQEPFWQIMKKVFDEEYKSKFVDAGVMK 249 Query: 215 -EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPER 273 D + V + + A N GD+L+D + G S + + Sbjct: 250 SGDELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGFITSNLVGVDE 309 Query: 274 TFPSL--FEPVHGSAPD-----IYGKNIA-NPIATIWAGAMMLDFLGNGD----ERFQQA 321 + FE HG+ D + G+ + NP+ + ++ + ER Sbjct: 310 NGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNVDKERTLAF 369 Query: 322 HNGILAAIEEVIAHGPKTPDMKGN--ATTPQVADAICKII 359 + A I ++ G T D+ G TT Q DA+ + + Sbjct: 370 TAKMRAVIHQLFREGKGTRDLSGPSGLTTEQFVDAVAERL 409 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 67/406 (16%), Positives = 119/406 (29%), Gaps = 60/406 (14%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 M + D G E+ ++++ L E + + + D Sbjct: 37 QMTTPLVEMD--GDEMTRIMWQMIKDELICPFVDLKTEYYDL-GLAHRDETDDQVTVDSA 93 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHI-----SLWGSLLKFRREFDQYVNLRPVRLFPGVPCP 118 E R A P+ R D V P+ + PC Sbjct: 94 EATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPIVVRGIDPCV 153 Query: 119 LAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ----------ESVFTRRG-- 166 +P + R Y R+ E+V FT G Sbjct: 154 KNWVRP----ITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVHEFTEPGVV 209 Query: 167 ---------VDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAM-----AEN 212 ++ R F+ A + + + ATK + + + + A Sbjct: 210 EGMHNLDASIESFARACFDFALATSQD-VWFATKDTISKTYDHRFKDIFQEIFDADYAAR 268 Query: 213 YP--EIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLN 270 + I + ID AR + F + N GD++SD+ + G++ + S + Sbjct: 269 FEAAGIEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAMMTSVLAS 327 Query: 271 PERTFPSLFEPVHGSAPDIYGKNIA------NPIATIWAGAMMLDFLGNGD--ERFQQAH 322 P + +E HG+ Y K++A N +ATI+A L D Sbjct: 328 PHGYW--EYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLADLAAFA 385 Query: 323 NGILAAIEEVIAHGPKTPDMKG--------NATTPQVADAICKIIL 360 + + A I G T D+ +T A+ + + Sbjct: 386 DALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDLK 431 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 72/378 (19%), Positives = 133/378 (35%), Gaps = 43/378 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYY--------SH 53 ++T+R+ G G G+E++ RV+Q A+++ F + Y+ + Sbjct: 3 IQTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVRSSSTYHSYHTLTVSGEDKN 62 Query: 54 HGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + D+ + + A G ++ L R+ Q + L Sbjct: 63 LITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYLVRQHLQAAKVEHFSLGD 122 Query: 114 GVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRY 173 G +VR+ +G Y+ + + + + F++ DRI+R+ Sbjct: 123 GNA------------LLMVRDEAQGFYAG---DNTYSADQLSITRTTSFSKPVFDRIIRF 167 Query: 174 AFELAQSR-----PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCA 228 A + A K +T A K + + + I +D D L Sbjct: 168 ALDRAAENWGPENVPKKVTMAYKFHLF---DGVFQAWEPQWKAQF-GIDFDFIQPDTLNR 223 Query: 229 RFVMQ-PERFDVVVASNLFGDILSDLGPACTGTIG----IAPSANLNPERTFPSLFEPVH 283 + + +++A N + D++ + G A + L P+ S ++ VH Sbjct: 224 SLMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETMYAENVYLRPDVNGLSEYQTVH 283 Query: 284 GSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDM 342 GSA I K + NP ATI A A +L G AI+ ++ TPD Sbjct: 284 GSADAIADKGLVNPFATIRAAAAILERHAGGKG-----IQKLTEQAIQSLLQRKLTTPDQ 338 Query: 343 KGNATTPQVADAICKIIL 360 G+ T + D + I Sbjct: 339 GGSLKTEETVDHFLQAIA 356 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 163 bits (413), Expect = 8e-39, Method: Composition-based stats. Identities = 67/377 (17%), Positives = 126/377 (33%), Gaps = 44/377 (11%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M +RI G G G E+ V++ A R+ + F + + Y + + D+ Sbjct: 4 MDPLRIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRIYHSY---NSLPLADE 60 Query: 62 WHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAG 121 + + + G + FR + V L Sbjct: 61 SQNATPDICDETVNDITHYQQFCEQEASRGLKVIFRTAIS-------AQSLYAVRQQLEA 113 Query: 122 KQPGDID-----FYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFE 176 + D V+R+ +G Y+ ++ + V + F + I+ ++ E Sbjct: 114 VKVECFDRGTSSLLVIRDQAQGFYTG---TNKLESDQDSVSRVCHFRKGVFQHIIAFSLE 170 Query: 177 LAQSR------PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARF 230 A+ + K++ K + + + I+ + D + Sbjct: 171 RAREKWGYDLGGIKSVFLVYKFHLF---DGLLLSWARDWTKEF-GIKVEFIQPDTMNRNL 226 Query: 231 VMQPERFDVVVASNLFGDILSDLG----PACTGTIGIAPSANLNPERTFPSLFEPVHGSA 286 + +++A N + DI+ + + + L P S ++ HGSA Sbjct: 227 IAFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSEYQTTHGSA 286 Query: 287 PDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVI----AHGPKTPDM 342 DI GK I NP ATI A A +L+ G I A +++ + + TPD Sbjct: 287 DDITGKGIVNPSATIRAAAAILERFGGCVG--------IDAKVDDTLNILQKNKSGTPDQ 338 Query: 343 KGNATTPQVADAICKII 359 GN TT D + + Sbjct: 339 GGNLTTAAFVDVFLRTL 355 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 163 bits (413), Expect = 9e-39, Method: Composition-based stats. Identities = 48/132 (36%), Positives = 67/132 (50%), Gaps = 8/132 (6%) Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 V P +FDV+V NL+GDILSDL G +G+ PS N+ ++FE VHG+APDI Sbjct: 30 MVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGAN--GVAIFESVHGTAPDI 87 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATT 348 GK++ANP A + + MML +G I A + I T D+ GN Sbjct: 88 AGKDMANPTALLLSAVMMLRHMG-----LHGHAKKIETACFDTIRDKKVLTKDLGGNPKC 142 Query: 349 PQVADAICKIIL 360 + IC+ + Sbjct: 143 SEFTADICRRVQ 154 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 160 bits (404), Expect = 8e-38, Method: Composition-based stats. Identities = 60/408 (14%), Positives = 115/408 (28%), Gaps = 87/408 (21%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I + GD E+ R+++ L + + + + E Sbjct: 87 IVEMDGD----EMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNR-DATDDKVTVESAEAT 141 Query: 67 SRFDAIYFGAVGWPDTV-----PDHISLWGSLLKFRREFDQYVNLRPV------RLFPGV 115 +++ A PD R + V P+ R+ PG Sbjct: 142 LKYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCLNIPRIVPGW 201 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSS-----------------------LGGRVNEGTE 152 P+ + R +Y + L V + Sbjct: 202 KKPIC----------IGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKG 251 Query: 153 HEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAEN 212 V + + + + LA + + L +TK+ L + + + + E Sbjct: 252 PGVALAMYNVDQS-IRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEE 309 Query: 213 -----YPE--IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAP 265 + E I ++ + ID + A V + V N GD+ SD + Sbjct: 310 KWKQKFEEHSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEA 361 Query: 266 SANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGD--ERFQQAHN 323 A LF+ ++ N IA+I+A L+ D E + Sbjct: 362 EAAHGTVTRHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVH 413 Query: 324 GILAAIEEVIAHGPKTPDMK----GN-------ATTPQVADAICKIIL 360 + + E + G T D+ G T + DA+ + + Sbjct: 414 KLEGSCIETVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLE 461 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 147 bits (372), Expect = 5e-34, Method: Composition-based stats. Identities = 48/197 (24%), Positives = 82/197 (41%), Gaps = 29/197 (14%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAER-WGFALSFEQMEWASCEYYSH---HGKMMPDDW 62 I I GDGIG ++ P I+V+ AA ++ +G ME + E + +P + Sbjct: 31 IPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTWLPQET 90 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGK 122 + + + G + P + + R++ D YV LRPVR F GVP P+ Sbjct: 91 LDAVKDYVVSIKGPLTT----PVGGGIRSLNVALRQQLDLYVCLRPVRWFEGVPSPVK-- 144 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGT-------------------EHEVVIQESVFT 163 +PGD+D + REN+E Y+ + + + + I + Sbjct: 145 KPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFDQDCGIGVKPVS 204 Query: 164 RRGVDRILRYAFELAQS 180 + G R+ R A A++ Sbjct: 205 KEGTKRLARKALHSAEA 221 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 142 bits (359), Expect = 2e-32, Method: Composition-based stats. Identities = 47/186 (25%), Positives = 76/186 (40%), Gaps = 16/186 (8%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I IPGDGIG E+ +++ AA + FE E A + Y G+++P+ +E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFET-ENAGSDVYEKTGELIPESLYES 57 Query: 66 LSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPG 125 + R G + P + R+++D Y N R R PG+ Sbjct: 58 VERNKIAIKGPITTPI----GKGFRSINVYLRKKYDLYTNFRSSRNLPGIETRY-----D 108 Query: 126 DIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKT 185 +ID + RENTEG Y NE I T++G + +L+ + + + Sbjct: 109 NIDLAIFRENTEGIYIGEEKYENEEKTS--AIAVKRITKKGSEELLKVLLNMQRIMEFRK 166 Query: 186 LTSATK 191 L K Sbjct: 167 LQLFIK 172 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats. Identities = 66/374 (17%), Positives = 126/374 (33%), Gaps = 53/374 (14%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAE--RWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 I I GDG G E+ I + +A E G + + E Y +GK +P + Sbjct: 17 TIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGKYLPRESI 76 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVP------- 116 E + + + G + +I+ + +R + Y +++ + PG+ Sbjct: 77 EDIRKTVFVMKGPLSS------NINGHDININIKRILNLYTDVKCITGLPGLSEGKEIFI 130 Query: 117 -CPLAGKQP------GDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDR 169 P + D D R+ Y ++ G + ++ +R + + Sbjct: 131 FSPSIDEVYHFSYDSEDSDML--RQ-----YLQQSFNISIGGDSDIF--LKGTSRYRIIK 181 Query: 170 ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCAR 229 I E++ K A G P W + + + + + Sbjct: 182 IASKIAEISSLYGIKRTLVADDYTGSHA--PLW--VYNTLNKMEMPVEIENLY---NLYD 234 Query: 230 FVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDI 289 + RF++ + + ++ + A T A L F SLFE + Sbjct: 235 EMTSESRFNIFIPDSRLSSLIIKIINART-----FFGAILGD---FISLFESQSRPSFTE 286 Query: 290 YGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP--DMKGNAT 347 G ++A+P + + A +MML L F A + A+ V + G ++ Sbjct: 287 EGYDLADPTSFLLASSMMLRRL-----NFNDAALILRNALNSVYSDGILPASLNLNNGLK 341 Query: 348 TPQVADAICKIILR 361 DAI K + R Sbjct: 342 CSDFIDAIVKRMKR 355 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 139 bits (350), Expect = 2e-31, Method: Composition-based stats. Identities = 43/174 (24%), Positives = 63/174 (36%), Gaps = 18/174 (10%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + PG G+G E+ + AA + +++ + ++ D Sbjct: 31 QFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHID-VDNAKPGQDLISADAL 85 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + L R G + P L R+ Y N+RP PGV P Sbjct: 86 DSLRRNRFGLKGPMATPI----GKGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY---- 137 Query: 124 PGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFEL 177 D+D VRENTEGEYS L V G VV V T V+ ++ F + Sbjct: 138 -DDVDVVTVRENTEGEYSGLEHVVYPG----VVESLKVITPERVNARVQVPFSI 186 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 133 bits (335), Expect = 1e-29, Method: Composition-based stats. Identities = 46/226 (20%), Positives = 89/226 (39%), Gaps = 18/226 (7%) Query: 138 GEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAI 197 G ++ L EG VV SV +++G D+ LRYAF+ A RK +T K+ I Sbjct: 2 GIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPI 57 Query: 198 SMPYWDERVEAMAENYPE-IRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 S E + + +Y + + + ++ +R + +P FD + AS + LS + Sbjct: 58 SDGSLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSG 117 Query: 257 CTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIAN--PIATIWAGAMMLDFLGNG 314 G + + + ++F+P+ + N AN + + LG+ Sbjct: 118 VCGGANLFSAVEIGDHH---AVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGH- 170 Query: 315 DERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKIIL 360 + + + ++ + G +T + G T V I + Sbjct: 171 ----DKCADALWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLR 212 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 132 bits (333), Expect = 2e-29, Method: Composition-based stats. Identities = 65/442 (14%), Positives = 116/442 (26%), Gaps = 122/442 (27%) Query: 7 IAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQL 66 I + GD E+ R+++ L + + + E Sbjct: 67 IVEMDGD----EMARIMWRMIKDKLIFPYLDLDIRYFDLGILNR-DATDDKVTVESAEAT 121 Query: 67 SRFDAIYFGAVGWPDTV-----PDHISLWGSLLKFRREFDQYVNLRPV------RLFPGV 115 +++ A PD R + V P+ R+ PG Sbjct: 122 LKYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPILCXNVPRIVPGW 181 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVV------------------- 156 P+ + R +Y + V + ++V Sbjct: 182 KKPIC----------IGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKG 231 Query: 157 --IQESVFTRRGVDR-ILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAENY 213 I +++ R + LA + + L +TK+ L Sbjct: 232 PGIALAMYNVDESIRAFAESSMSLAFA-KKWPLYLSTKNTILKKYDG------------- 277 Query: 214 PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPA----------------- 256 R++ + ID + A + + V N GD+ SDL Sbjct: 278 ---RYEHRLIDDMVAYALKSDGGY-VWACKNYDGDVQSDLLAQGFLLHMRNERSDYPVXL 333 Query: 257 ----------------CTGTIGI---APSANLNPERTFPSLFEPVHGSAPDI---YGKNI 294 G+ L+ + E HG+ Y K + Sbjct: 334 HLVKSYPILFVLSRIRFFGSYDFSIAISGKQLSSDGKTL-EAEAAHGTVTRHFRQYQKGL 392 Query: 295 ---ANPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMK----GN 345 N IA+I+A L+ D ER + + AA E + G T D+ G Sbjct: 393 ETSTNSIASIFAWTRGLEHRAKLDKNERLLDFVHKLEAACIETVESGNMTKDLAILIHGP 452 Query: 346 -------ATTPQVADAICKIIL 360 T + D + + Sbjct: 453 KASXEFYLNTEEFIDTVAHNLE 474 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats. Identities = 47/263 (17%), Positives = 103/263 (39%), Gaps = 10/263 (3%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 ++A + GD V+ + +++++ A ++ + + +P+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDS-TAFEVTELPF-GVNGVLSFNEPLPNQTLR 59 Query: 65 QLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV--PCPLAGK 122 +L +D I GA+ +S+ SL+ R+ + + + V++ PL + Sbjct: 60 ELKNYDGILVGALNQEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLKNQ 119 Query: 123 QPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRP 182 D DF +V+ + + + + +R V++++ FE A +R Sbjct: 120 IVRDTDFIIVQSAK----RANDHVDGNISVDDFAQDTITYEQREVEQVITAGFERAMNRK 175 Query: 183 RKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVMQPERFDVVVA 242 R +T T + + W E +A+ YP++ + + + + + QP DVVVA Sbjct: 176 RA-VTVVTPFDSF-YTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDVVVA 233 Query: 243 SNLFGDILSDLGPACTGTIGIAP 265 +L++ TG P Sbjct: 234 PKWVDQVLNEESQKITGLPETVP 256 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 126 bits (316), Expect = 2e-27, Method: Composition-based stats. Identities = 74/374 (19%), Positives = 127/374 (33%), Gaps = 46/374 (12%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEY-------YSHHGKMM 58 + G G G+EV RVL A R ++ + Y G + Sbjct: 32 TVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSPRVYHSYVSLRPLATEPGGAGV 91 Query: 59 PD---DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV 115 P+ E + ++ V ++ L R+ LR V+ Sbjct: 92 PEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQ-----RLRAVK----- 141 Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 + +VR+ +G Y+ V + + F+R +++L YA Sbjct: 142 ---VDTLDADGARLLLVRDEAQGFYTG-----GNTHTPGHVSRTTEFSREITEQLLAYAL 193 Query: 176 ELAQSR---PRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIRWDKQHIDILCARFVM 232 A+ + A K + L D V A I D + V Sbjct: 194 RRAREEWPEGPARIVMAYKFHLL---DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLVA 249 Query: 233 QP-ERFDVVVASNLFGDILSDLGPACTGTI----GIAPSANLNPERTFPSLFEPVHGSAP 287 P E V++A N + DI+ + G+ + +L+P ++ VHGSA Sbjct: 250 HPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAVAELVEYQTVHGSAD 309 Query: 288 DIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNA 346 D+ G+++ NP+AT+ A A + ++G A V +TPD G Sbjct: 310 DLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGV-----RTPDQGGKH 364 Query: 347 TTPQVADAICKIIL 360 +T V DA + + Sbjct: 365 STTGVVDAFIEELG 378 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 121 bits (304), Expect = 4e-26, Method: Composition-based stats. Identities = 66/125 (52%), Positives = 80/125 (64%), Gaps = 12/125 (9%) Query: 242 ASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIAT- 300 N+FGDILSDLGPACTGTI +APS ++NPE FPSLFEPVHGS PDI+GK IANPI Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 301 --IWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHG----PKTPDMKGNATTPQVADA 354 GAM+LD LG + I + IE+V++ G P TPD+ G+A T + A Sbjct: 61 ARFGVGAMILDHLGY-----PETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKA 115 Query: 355 ICKII 359 I I Sbjct: 116 IAAAI 120 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 33/114 (28%), Positives = 48/114 (42%), Gaps = 3/114 (2%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 K I +PGDGIG EV+ VL+ A G F++M C G +P++ Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGC-ALDLTGVPLPEE 98 Query: 62 WHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFP 113 + DA+ GA+G H+ LL+ R + NLRP + P Sbjct: 99 TLLVAKQSDAVLLGAIGGYKWDSNEKHLKPETGLLQLRSGLKVFANLRPASVLP 152 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 105 bits (261), Expect = 4e-21, Method: Composition-based stats. Identities = 31/111 (27%), Positives = 46/111 (41%), Gaps = 9/111 (8%) Query: 96 FRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEV 155 D Y ++ ++ P V D+D VV ENTEGEYS+L +G V Sbjct: 2 LHTTLDLYASVIHLKNLPNVET-----WHKDVDILVVWENTEGEYSNLEHESVKG----V 52 Query: 156 VIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERV 206 + T+ RI YAF+LAQ K + + K N + + + Sbjct: 53 TESLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 99.6 bits (247), Expect = 1e-19, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 62/164 (37%), Gaps = 14/164 (8%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQ-AAAERWGFALSFEQMEWASCEYYSHHGKMMP 59 M + ++ + GD IG E++ E ++ L ER F + A + + Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAG-ASLDKTNEPIT 59 Query: 60 DDWHEQLSRFDAIYFGAVGWPDT--VPDHISLWGSLLKFRREFDQYVNLRPVRLFPGV-- 115 D + DA+ G+VG P+ +P ++ +L+ R+ D + N+RP R Sbjct: 60 DKVLDAALATDAVLLGSVGEPEWAHMPGALNPEKGILRLRQRLDAFANIRPCRFCASSLV 119 Query: 116 -PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQ 158 PL ++F +Y++ ++ + Sbjct: 120 EQSPLKSDMVNGVNF-------GEQYAARSRSTGGCCTKDIGLA 156 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 97.7 bits (242), Expect = 6e-19, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 46/134 (34%), Gaps = 15/134 (11%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWH 63 + IPGDGIG E+L + + + + FE + S + Sbjct: 50 RHTVTLIPGDGIGPELLNHVRELFRFSC----VPVDFEVVHVNSSSTSEDDIS----NAI 101 Query: 64 EQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQ 123 + R G + T+P + R D Y N+ + PGV + Sbjct: 102 MAIRRNGVALKGNIETNHTMPPN--HKSRNNLLRTSLDLYANVMHCQSLPGVQT-----R 154 Query: 124 PGDIDFYVVRENTE 137 +ID ++ E +E Sbjct: 155 HKNIDIIIILEKSE 168 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 97.3 bits (241), Expect = 7e-19, Method: Composition-based stats. Identities = 52/227 (22%), Positives = 86/227 (37%), Gaps = 30/227 (13%) Query: 159 ESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPY---WDERVEAMAENY-- 213 + + F A S K + K + + ++ +A ++ Sbjct: 357 LMSNDHEAIKDWVSQVFRDASS-KHKEVYFGLKREYMEYDEVFSTVINDVRRELAADHTS 415 Query: 214 -PEIRWDKQHIDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPE 272 P + + P R + A NL GDI SD+ A G++ A S + Sbjct: 416 PPAFMI--MRPSSQLIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASS--IIES 471 Query: 273 RTFPSLFEPVHGSAPDIYGKNIA--------NPIATIWAGAMMLDFLG--NGDERFQQAH 322 ++ LFE HG+A D+Y K + NP A I+A A L+ LG +E Sbjct: 472 KSSTMLFEAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYS 531 Query: 323 NGILAAIEEVIAHGPKTPDMKGNATTPQ---------VADAICKIIL 360 + AA+++ + G T D+K TTP+ D+I K + Sbjct: 532 ARLKAALKDTVGDGIVTADLKDKTTTPESETLVDMMGFLDSIEKRLG 578 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 94.2 bits (233), Expect = 6e-18, Method: Composition-based stats. Identities = 65/356 (18%), Positives = 110/356 (30%), Gaps = 80/356 (22%) Query: 2 MKTMRIAAIPGD--GIGKEVLPEGI---RVLQAA--------------AERWGFALSFEQ 42 M +IA IPGD GIG E++ + + V +AA A + G L + Sbjct: 6 MTKPKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLDP 65 Query: 43 MEWASCEYYSHHGKMMPDDWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQ 102 + WA+ + + E + D S +L + D Sbjct: 66 IAWANLAEF----SGLRQLEMETIDVADV--------KVAEVTIQSGKSALRTLDQALDL 113 Query: 103 YV--NLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE------YSSLGGRVNEGTEHE 154 V + V P L N E E Y G +E + Sbjct: 114 AVAGIVDGVLFGPFNKAALTAAGL----------NAEDEHRYMARYLGFKGYHSEVNVLD 163 Query: 155 VVIQESV------------FTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPY 201 ++ V T GV + + A + + A + N A Sbjct: 164 DLMTTRVTSHIGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGK 223 Query: 202 W-DERVEAMAENYPEIRWDKQHID----ILCARFVMQPERFDVVVASNLFGDILSDLGPA 256 + E ++ +A E + H+ + D VV ++ D + Sbjct: 224 FGREEIDILAPVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIK 280 Query: 257 CTG---TIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLD 309 G + +A + + P HG+A DI G+++AN AT A ++L Sbjct: 281 LMGFDRGVTVAGGLPI-------PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLR 329 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 93.1 bits (230), Expect = 1e-17, Method: Composition-based stats. Identities = 29/113 (25%), Positives = 48/113 (42%), Gaps = 7/113 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 +I I GDGIG E++ E +VL ++G + +E + C G + D+ Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCS-IDATGVPLTDEAIAA 62 Query: 66 LSRFDAIYFGAVGWPDTVPDH------ISLWGSLLKFRREFDQYVNLRPVRLF 112 DA+ G++G + LLK R+ + + NLRP L+ Sbjct: 63 AKASDAVLMGSIGGNTATSPWYKLAPELRPEAGLLKLRKSLNLFANLRPAYLY 115 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 92.7 bits (229), Expect = 2e-17, Method: Composition-based stats. Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 21/153 (13%) Query: 228 ARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAP 287 ++ + P R+ + A NL GDI SD+ A G++ A S + + T LFE HG+A Sbjct: 429 SKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTL--LFEAPHGTAH 486 Query: 288 DIYGKNIA--------NPIATIWAGAMMLDFLGNGDERFQ--QAHNGILAAIEEVIAHGP 337 D+Y + + N A I+A A L+ L ++ + + AA+ E +A G Sbjct: 487 DLYLRYLETDGKEANFNSSALIFAVANALEELARREDNAPLAEYAEALKAALIETVAQGT 546 Query: 338 KTPDMKGNATTPQ---------VADAICKIILR 361 T D+KG P+ DAI + + Sbjct: 547 ITGDLKGKTLAPESETVVDMYGFLDAIESNLNK 579 Score = 45.3 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 36/297 (12%), Positives = 83/297 (27%), Gaps = 60/297 (20%) Query: 1 MMKTMRI----AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGK 56 M + +++ + GD E+ + + +++ ++ + + +G+ Sbjct: 1 MGERIKVEKPLVILHGD----EMAQIAFERILEQFVTSRLDIQLVEVDLSAEQRLTSNGQ 56 Query: 57 MMPDDWHEQLSRFDAIYFGAVGWPDTVP----------------DHISLWGSLLKFRREF 100 ++ + E L A + D ++ R+ Sbjct: 57 VVL-EAIEALKDHGIGVKNAGMTVNRSQLDEMLAKYPQINEAQLDKLATKSPNGAIRKGI 115 Query: 101 DQYVNL-RPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGE---YS------SLGGRVNEG 150 N+ R F + DI+ + + G YS + + G Sbjct: 116 GG--NITREDIEFRNLTSVRPDWVNRDIEVDTM--ESGGLDFSYSELSDATGVAKVMFVG 171 Query: 151 TEHEVVIQESVFTRRG------------VDRILRYAFELAQSRPRKTLTSATKSNGLAIS 198 + + V ++G V F+ A R + K + Sbjct: 172 SSGDPVELHRRTLKKGDPWMLATNDLDDVKAWAHRFFQRALDEKRD-IYLGLKDTVVPGY 230 Query: 199 MPYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERFDVV-VASNLFG 247 +E + +++ + ID AR V P + + V N+ G Sbjct: 231 DGVMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNPPQRALWGVPDNVSG 287 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 85.0 bits (209), Expect = 4e-15, Method: Composition-based stats. Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 6/80 (7%) Query: 282 VHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK-TP 340 VHGSAP G NP A + +G MML +L +A I +++V+A T Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKWLNE-----HEAATRIEKGVDKVLAEAKHLTY 58 Query: 341 DMKGNATTPQVADAICKIIL 360 D G A+T + ADAI K + Sbjct: 59 DAGGTASTDEYADAIIKAMG 78 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 84.2 bits (207), Expect = 6e-15, Method: Composition-based stats. Identities = 29/87 (33%), Positives = 47/87 (54%), Gaps = 8/87 (9%) Query: 279 FEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPK 338 +EP GSAPDI GKNIANPIA I + AM++ + + + I +A+ + + G + Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRY----TMKLPIISDQIESAVIDTLKKGYR 66 Query: 339 TPDMKGNA----TTPQVADAICKIILR 361 T D+ + +T + D I I+ + Sbjct: 67 TLDIANDKEKCESTNDIGDIISYILKK 93 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 83.5 bits (205), Expect = 1e-14, Method: Composition-based stats. Identities = 44/81 (54%), Positives = 57/81 (70%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M + RIA IPGDGIGKE +PE +RV AAA R+GFAL ++AS + + HGK+ PDD Sbjct: 1 MSSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDD 60 Query: 62 WHEQLSRFDAIYFGAVGWPDT 82 + L +DA++FGAVG PDT Sbjct: 61 RFDTLRGYDALFFGAVGRPDT 81 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 81.9 bits (201), Expect = 3e-14, Method: Composition-based stats. Identities = 31/198 (15%), Positives = 60/198 (30%), Gaps = 34/198 (17%) Query: 89 LWGSLLKFRREFDQYVNLRPVRLFPGVPCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVN 148 R + V P+ L VP L+G + + R +Y + +N Sbjct: 31 WRSPNGTIRNILNGTVFREPI-LCKNVPRILSGWKKP---ICIGRHAFGDQYRATDTIIN 86 Query: 149 EGTEHEVV--------------------IQESVFTRRGVDR-ILRYAFELAQSRPRKTLT 187 + ++V + S++ R + +A S + L Sbjct: 87 GPGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALS-KKWPLY 145 Query: 188 SATKSNGLAISMPYWDERVEAM-------AENYPEIRWDKQHIDILCARFVMQPERFDVV 240 +TK+ L + + + + I ++ + ID + A V + V Sbjct: 146 LSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGY-VW 204 Query: 241 VASNLFGDILSDLGPACT 258 N GD+ SD Sbjct: 205 ACKNYDGDVQSDFLAQIF 222 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 81.1 bits (199), Expect = 6e-14, Method: Composition-based stats. Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 5/105 (4%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDD 61 M T I + GDGIG E+ E ++VL +A C G + Sbjct: 360 MTTHTILVLRGDGIGLEITAEAVKVL-SAFSLKKRTFDLRSELIDGCS-IDTDGTPITKT 417 Query: 62 WHEQLSRFDAIYFGAVGWPDT---VPDHISLWGSLLKFRREFDQY 103 + DA+ F +VG P D G LL+ R+ +Q+ Sbjct: 418 VIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 80.0 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 27/78 (34%), Positives = 38/78 (48%), Gaps = 1/78 (1%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 K IA +PGDG+G EV+P + VL A G SFE++ G +P + Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGV-ALDLVGVPLPKET 97 Query: 63 HEQLSRFDAIYFGAVGWP 80 + + DA+ GAVGW Sbjct: 98 LIRAKQSDALLLGAVGWY 115 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 75.4 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 8/82 (9%) Query: 284 GSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMK 343 GSAPDI GKNIANPIA I + AM++ + + + + I +++ + + G KT D+ Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRY----TMKLHKIADDIESSVIDALKKGYKTLDIA 57 Query: 344 G----NATTPQVADAICKIILR 361 + +T + D I I+ + Sbjct: 58 NVNETHISTSDMGDVISNILNK 79 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 75.4 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 6/67 (8%) Query: 294 IANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGP-KTPDMKGNATTPQVA 352 IANP A + + ML + Q I AI EV+A G +T D+ G+++T + Sbjct: 155 IANPTAMLMCASKMLRHV-----NLQHYSESIRNAIREVLAAGKVRTRDLGGSSSTHEFT 209 Query: 353 DAICKII 359 DA+ K I Sbjct: 210 DAVIKAI 216 Score = 71.1 bits (173), Expect = 6e-11, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 42/103 (40%), Gaps = 8/103 (7%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDW 62 + + IPGDG+ E++ VL+A G + FE + ++ ++ +D Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAI----GAPIDFETILFSEVQH---SSSAKVEDV 115 Query: 63 HEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVN 105 + ++R GA+ PD L +K R+ D N Sbjct: 116 IKSINRNRICLMGALMSPDVSYSGE-LQNLHMKLRKGLDLIAN 157 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 73.4 bits (179), Expect = 1e-11, Method: Composition-based stats. Identities = 34/79 (43%), Positives = 43/79 (54%), Gaps = 2/79 (2%) Query: 3 KTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWG-FALSFEQMEWASCEYYSHHGKMMPDD 61 KT +IA+IPGD IG EV+ I VL++ E + L F +++W Y GK MP D Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDW-GTARYKRTGKYMPAD 65 Query: 62 WHEQLSRFDAIYFGAVGWP 80 L F A FGAVG P Sbjct: 66 GLSTLKTFHAGIFGAVGAP 84 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 71.5 bits (174), Expect = 4e-11, Method: Composition-based stats. Identities = 32/129 (24%), Positives = 50/129 (38%), Gaps = 9/129 (6%) Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDHISLWGSLLKFRREFDQYVNLRPVRLFPGVPCPLA 120 + + F ++ LK + D YV R FPG C Sbjct: 99 EAGQDDEYFHSVLRNRTAVHVDNQADAEAKQKALKICNDLDLYVFKTRTRSFPGFKC--- 155 Query: 121 GKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAFELAQS 180 + +D ++ +N G ++ L EG VV SV +++G D+ LRYAF+ A Sbjct: 156 --RFPGVDIQLIGQNNMGIFNELEYSPVEG----VVEALSVVSQKGNDKYLRYAFKAAAK 209 Query: 181 RPRKTLTSA 189 RK +T Sbjct: 210 AGRKRVTLI 218 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 68.4 bits (166), Expect = 4e-10, Method: Composition-based stats. Identities = 29/79 (36%), Positives = 37/79 (46%), Gaps = 3/79 (3%) Query: 281 PVHGSAPDIYGKNIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTP 340 P+HG APDI G IANP A + A +L G +E QQ N I +A E TP Sbjct: 209 PMHGHAPDIVGMGIANPYALLMAFCRLLTVAGY-EELAQQVENQIESAFYE--NRDQTTP 265 Query: 341 DMKGNATTPQVADAICKII 359 D G T + + + I Sbjct: 266 DQGGVLNTEKYMAMMVECI 284 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 65.3 bits (158), Expect = 3e-09, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 28/75 (37%), Gaps = 11/75 (14%) Query: 293 NIANPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKG------NA 346 NIANP + A ML ++G I A + + G T D+ Sbjct: 6 NIANPSGLLNAAVHMLIYIGQVGT-----AKLIYDAWLKTLEGGIHTADLYKEKRSKQKV 60 Query: 347 TTPQVADAICKIILR 361 T + A+A+ + + Sbjct: 61 GTKEFAEAVIDNLGK 75 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 65.3 bits (158), Expect = 4e-09, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 31/77 (40%), Gaps = 5/77 (6%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHEQ 65 R+ IPGDGIG E+ ++ +AA + ++ ++ + + +P E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAA----NAPIEWDPVDVTPVKGDDGIFR-IPSKCIEL 81 Query: 66 LSRFDAIYFGAVGWPDT 82 + G + P+ Sbjct: 82 MRINKIGLKGPLATPNW 98 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 65.0 bits (157), Expect = 4e-09, Method: Composition-based stats. Identities = 27/61 (44%), Positives = 33/61 (54%), Gaps = 1/61 (1%) Query: 278 LFEPVHGSAPDIYGKNIANPIATIWAGAMML-DFLGNGDERFQQAHNGILAAIEEVIAHG 336 +FEP HGSAPDI G+NIANPIA IW+GA ML G + A + V+ Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHRHPSAAGHGANKAVMIDA 60 Query: 337 P 337 Sbjct: 61 T 61 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 63.8 bits (154), Expect = 1e-08, Method: Composition-based stats. Identities = 17/82 (20%), Positives = 28/82 (34%), Gaps = 7/82 (8%) Query: 5 MRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPDDWHE 64 + IPGDGIG E+ + + + +EQ + G+ + E Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYV----NAPIEWEQYNVSGMSSA---GEDLFKQAVE 61 Query: 65 QLSRFDAIYFGAVGWPDTVPDH 86 L R G + P + H Sbjct: 62 SLRRNRVGLKGILFTPISQSGH 83 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 61.9 bits (149), Expect = 4e-08, Method: Composition-based stats. Identities = 28/107 (26%), Positives = 37/107 (34%), Gaps = 31/107 (28%) Query: 253 LGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDFLG 312 +GP +G+ L E ++Y KNIANP AT+ A MMLD L Sbjct: 25 VGPELMAAVGVIECLKLGDGLFLQCCEE-----VAELYPKNIANPTATLLASCMMLDHL- 78 Query: 313 NGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTPQVADAICKII 359 KT DM G AT +A+ + Sbjct: 79 -------------------------KTSDMGGYATCQDFTEAVIGAL 100 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 60.0 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 10/93 (10%) Query: 116 PCPLAGKQPGDIDFYVVRENTEGEYSSLGGRVNEGTEHEVVIQESVFTRRGVDRILRYAF 175 L G QP ++ +V EN EGEYS GR + E++I + + A+ Sbjct: 80 RSSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG---------LSKIAY 130 Query: 176 ELAQSRPRKTLTSATKSNGLAISMPYWDERVEA 208 +L + P K + ATKSN + W+E Sbjct: 131 QLLRG-PEKHIAIATKSNAQRNGLVIWNEVAAE 162 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 56.9 bits (136), Expect = 1e-06, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 30/102 (29%), Gaps = 3/102 (2%) Query: 148 NEGTEHEVVIQESVFTRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVE 207 + + V +R A + + L A K N + + + Sbjct: 138 PREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDDLVVAHKGNSIKHTDGLFALTAA 197 Query: 208 AMAEN---YPEIRWDKQHIDILCARFVMQPERFDVVVASNLF 246 E+ I W ID + A V P + ++ + F Sbjct: 198 ETLESLAGAAGIAWRSLIIDHMAAELVRNPLDYRAILTHSSF 239 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 55.3 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 27/55 (49%), Gaps = 3/55 (5%) Query: 1 MMKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHG 55 M K +I +PGDGIG E++ E ++VL+ A E++ + HG Sbjct: 8 MSK--QILILPGDGIGPEIMTEAVKVLELANEKYQLGFELT-HDVIGGAAIDKHG 59 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 55.3 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 18/62 (29%), Positives = 27/62 (43%), Gaps = 6/62 (9%) Query: 300 TIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAH-GPKTPDMKGNATTPQVADAICKI 358 + A +MLD L + N I +AI + T D+ G TT +V +I +I Sbjct: 1 MLLASCLMLDHL-----KLHDYANMIRSAILTTMNETRLHTVDIGGQGTTSEVVQSIMRI 55 Query: 359 IL 360 I Sbjct: 56 IQ 57 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 49.6 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 6/37 (16%), Positives = 19/37 (51%) Query: 181 RPRKTLTSATKSNGLAISMPYWDERVEAMAENYPEIR 217 R + +T K+N + ++ + +A+++P++ Sbjct: 75 RVEEKVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 49.6 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 16/47 (34%), Positives = 28/47 (59%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYS 52 +I A+ GDGIG E++ G+ VL+A AE+ GF ++ + + + Sbjct: 4 KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGADIDA 50 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 48.8 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 12/113 (10%), Positives = 25/113 (22%), Gaps = 10/113 (8%) Query: 3 KTMRI--AAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWASCEYYSHHGKMMPD 60 K +++ + D G E+ ++ + + + Y + Sbjct: 42 KRIKVSQPVVEMD--GDEMTRIIWEFIKEKLILSNVDVELKYYDL-GLPYRDQTDDQVTI 98 Query: 61 DWHEQLSRFDAIYFGAVGWPDTVPDH-----ISLWGSLLKFRREFDQYVNLRP 108 D ++ A PD R V P Sbjct: 99 DSAIATQKYHVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTVFREP 151 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 47.2 bits (111), Expect = 0.001, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 15/27 (55%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAE 32 + IPGDGIG E+ +++ AA Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKA 32 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 46.1 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 15/79 (18%), Positives = 25/79 (31%), Gaps = 14/79 (17%) Query: 296 NPIATIWAGAMMLDFLGNGD--ERFQQAHNGILAAIEEVIAHGPKTPDMKG--------- 344 NPIA+I+A L D + N + E I G T D+ Sbjct: 6 NPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSAQ 65 Query: 345 ---NATTPQVADAICKIIL 360 T + + + + + Sbjct: 66 CSDYLNTFEFMEKLGENLK 84 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 45.3 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 22/37 (59%) Query: 6 RIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQ 42 +I A+ GDGIG E++ G+ VL+A AE+ + Sbjct: 4 KIVALVGDGIGPEIMEAGLEVLEALAEKQVLTMRLTD 40 >UniRef50_UPI0001AF257B hypothetical protein SrosN15_15958 n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF257B Length = 177 Score = 44.5 bits (104), Expect = 0.007, Method: Composition-based stats. Identities = 26/174 (14%), Positives = 46/174 (26%), Gaps = 18/174 (10%) Query: 188 SATKSNGLAISMPYWDERVEAMAENY---PEIRWDKQHIDILCARFVMQPERFDVVVASN 244 K N + + + + E I + ID + A P+ + ++ Sbjct: 1 MTHKGNSIKYTDGLFAVVAKQELEKLIGDSGIIQESLIIDHMAAELTRNPQDYRAILTHG 60 Query: 245 ---------LFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPVHGSAPDIYGKNIA 295 L G + +D TIG A + H AP+ Sbjct: 61 AFAELLAALLDGQLDTD-AGGVCRTIGTARRPLFGYDVALDP---ARHTRAPEAEAAGRL 116 Query: 296 NPIATIWAGAMMLDFLGNGDERFQQAHNGILAAIEEVIAHGPKTPDMKGNATTP 349 + + AG+++ D L G T + A T Sbjct: 117 RSV--LLAGSLLADHLDQGVAAAGIRAAADALDAPATADGHAGTAGLAACARTA 168 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 44.2 bits (103), Expect = 0.008, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 25/52 (48%), Gaps = 6/52 (11%) Query: 310 FLGNGDERFQQAHNGILAAIEEVIA-HGPKTPDMKGNATTPQVADAICKIIL 360 +G G++ N I A+E+V+ +T + G+ATT + A + + Sbjct: 39 HVGEGEK-----ANAIRNAVEKVLNIDNVRTGGLGGSATTKEFTAATERRLA 85 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 43.8 bits (102), Expect = 0.009, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 31/83 (37%), Gaps = 14/83 (16%) Query: 292 KNIANPIATIWAGAMMLDFLGNGDE--RFQQAHNGILAAIEEVIAHGPKTPDM----KGN 345 K NPIA+I+A + L+ D+ R + + A E + G + D+ G Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 346 --------ATTPQVADAICKIIL 360 T+ + D + + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERLK 85 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 43.8 bits (102), Expect = 0.009, Method: Composition-based stats. Identities = 10/71 (14%), Positives = 23/71 (32%), Gaps = 8/71 (11%) Query: 163 TRRGVDRILRYAFELAQSRPRKTLTSATKSNGLAISMPYWDERVEAMAE-------NYPE 215 T + + A + L +TK+ L + + + + E Sbjct: 1 TDESIYSFAEASMTTAYE-KKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAG 59 Query: 216 IRWDKQHIDIL 226 I ++ + ID + Sbjct: 60 IWYEHRLIDDM 70 >UniRef50_C5F751 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Lactobacillus paracasei subsp. paracasei 8700:2 RepID=C5F751_LACPA Length = 326 Score = 42.2 bits (98), Expect = 0.027, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 54/158 (34%), Gaps = 17/158 (10%) Query: 161 VFTRRGVDRILRYAFELAQSRPRKTLTSATKS-NGLAISMPYW-DERVEAMAENYPEIRW 218 + T+ V+ + A + A N A + DE ++ + E + Sbjct: 174 LVTKARVEECIDLANSAIKRLGISKPRIAVAGLNPHAGEDGLFGDEEIKEINPAVKEKQS 233 Query: 219 DKQHIDIL----CARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSAN--LNPE 272 + +FD+VVA ++ D G + N L Sbjct: 234 QGIDVQGALPPDTVFLKASQGKFDIVVA--MYHD----QGHIPMKLLAFDEGVNVTLGLP 287 Query: 273 RTFPSLFEPVHGSAPDIYGKNIANPIATIWAGAMMLDF 310 S+ HG+A DI GK IAN + + + A+ + F Sbjct: 288 IIRTSV---DHGTAFDIAGKGIANESSMLASIALAIKF 322 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 42.2 bits (98), Expect = 0.031, Method: Composition-based stats. Identities = 10/45 (22%), Positives = 18/45 (40%), Gaps = 4/45 (8%) Query: 2 MKTMRIAAIPGDGIGKEVLPEGIRVLQAAAERWGFALSFEQMEWA 46 ++ PGDGIG E+ +V AA + +++ Sbjct: 41 STPIKATLFPGDGIGPEIAESVKQVFTAA----DVVIDWDEQFVG 81 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 41.8 bits (97), Expect = 0.033, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 13/26 (50%) Query: 4 TMRIAAIPGDGIGKEVLPEGIRVLQA 29 + IPGDGIG E++ V + Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_Q9I1Q5 4-hydroxythreonine-4-phosphate dehydrogenase 2 n=10 Tax=Proteobacteria RepID=PDXA2_PSEAE Length = 337 Score = 41.8 bits (97), Expect = 0.034, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 31/94 (32%), Gaps = 16/94 (17%) Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTG---TIGIAPSANLNPERTFPSLF 279 D + + FD VV ++ D + G + + + + Sbjct: 252 ADTIFLKVQGDARAFDAVVT--MYHD-QGQIAIKLMGFSRGVTVQGGLPI-------PIA 301 Query: 280 EPVHGSAPDIYGKNIANPIATIWA---GAMMLDF 310 P HG+A DI G+ A+ AT A M Sbjct: 302 TPAHGTAFDIAGQGRADVGATRQAFEIACRMGRH 335 >UniRef50_Q1Q0V0 Similar to pyridoxal phosphate biosynthetic protein pdxA n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q0V0_9BACT Length = 346 Score = 41.5 bits (96), Expect = 0.053, Method: Composition-based stats. Identities = 22/88 (25%), Positives = 35/88 (39%), Gaps = 12/88 (13%) Query: 223 IDILCARFVMQPERFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERTFPSLFEPV 282 D + + + ++D+VV+ ++ D + N+ F P Sbjct: 261 ADTVFYKALK--GQYDLVVS--MYHD-QGAIPLKLH---AFETGVNITLGIPFIRT-SPD 311 Query: 283 HGSAPDIYGKNIANPIAT---IWAGAMM 307 HG+A DI GK IANP + I MM Sbjct: 312 HGTAYDIAGKGIANPDSMKEAIMTAIMM 339 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.312 0.146 0.402 Lambda K H 0.267 0.0446 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,275,439,714 Number of Sequences: 3077464 Number of extensions: 95779612 Number of successful extensions: 267676 Number of sequences better than 1.0e-01: 242 Number of HSP's better than 0.1 without gapping: 579 Number of HSP's successfully gapped in prelim test: 89 Number of HSP's that attempted gapping in prelim test: 264111 Number of HSP's gapped (non-prelim): 747 length of query: 361 length of database: 1,040,396,356 effective HSP length: 130 effective length of query: 231 effective length of database: 640,326,036 effective search space: 147915314316 effective search space used: 147915314316 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 94 (40.7 bits)