Phyre 2 Results for Q2M7X4

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Email | l.a.kelley@imperial.ac.uk
Description | Q2M7X4
Date | Thu Jan 5 12:34:02 GMT 2012
Unique Job ID | 50b0e543e40ddc26

Summary |

Top model
Image coloured by rainbow N → C terminus
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Model (left) based on template c2dhyA_
Top template information
PDB header:immune system Chain: A: PDB Molecule:cue domain-containing protein 1; PDBTitle: solution structure of the cue domain in the human cue2 domain containing protein 1 (cuedc1)
Confidence and coverage
Confidence: | 21.5% | Coverage: | 48%
47 residues ( 48% of your sequence) have been modelled with 21.5% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | K | P | T | T | L | L | L | I | F | T | F | F | A | M | P | G | I | V | Y | A | E | S | P | F | S | S | L | Q | S | A | K | E | K | T | T | V | L | Q | D | L | R | K | I | C | T | P | Q | A | S | L | S | D | E | A | W | E | K | L | M
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  | ? | ? | ? |  | ? |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | .
Sequence |  | L | S | D | E | N | N | K | Q | H | I | R | E | A | I | V | A | M | E | R | N | N | Q | S | N | Y | W | E | A | L | G | K | V | E | C | P | D | M
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c2dhyA_ |

### PDB 2dhy chain A

Region: 35 - 84
Aligned: 47
Modelled: 50
Confidence: 21.5%
Identity: 9%
PDB header:immune system
Chain: A: PDB Molecule:cue domain-containing protein 1;
PDBTitle: solution structure of the cue domain in the human cue2 domain containing protein 1 (cuedc1)

Phyre2
2 |
| c3fpjA_ |

### PDB 3fpj chain A

Region: 35 - 71
Aligned: 37
Modelled: 37
Confidence: 11.5%
Identity: 11%
PDB header:biosynthetic protein, transferase
Chain: A: PDB Molecule:putative uncharacterized protein;
PDBTitle: crystal structure of e81q mutant of mtnas in complex with s-2 adenosylmethionine

Phyre2
3 |
| c2d1lA_ |

### PDB 2d1l chain A

Region: 35 - 92
Aligned: 45
Modelled: 53
Confidence: 8.9%
Identity: 27%
PDB header:protein binding
Chain: A: PDB Molecule:metastasis suppressor protein 1;
PDBTitle: structure of f-actin binding domain imd of mim (missing in metastasis)

Phyre2
4 |
| d1unda_ |

### PDB 1und chain A

Region: 50 - 60
Aligned: 11
Modelled: 11
Confidence: 7.9%
Identity: 18%
Fold: VHP, Villin headpiece domain
Superfamily: VHP, Villin headpiece domain
Family: VHP, Villin headpiece domain

Phyre2
5 |
| c3q8iA_ |

### PDB 3q8i chain A

Region: 32 - 60
Aligned: 29
Modelled: 29
Confidence: 7.3%
Identity: 21%
PDB header:odorant binding protein
Chain: A: PDB Molecule:odorant binding protein;
PDBTitle: crystal structure of anopheles gambiae odorant binding protein 4 in2 complex with indole

Phyre2
6 |
| c2k6nA_ |

### PDB 2k6n chain A

Region: 49 - 60
Aligned: 12
Modelled: 12
Confidence: 7.1%
Identity: 33%
PDB header:structural protein
Chain: A: PDB Molecule:supervillin;
PDBTitle: solution structure of human supervillin headpiece, minimized2 average

Phyre2
7 |
| c2o42B_ |

### PDB 2o42 chain B

Region: 33 - 45
Aligned: 13
Modelled: 13
Confidence: 7.0%
Identity: 31%
PDB header:apoptosis inhibitor
Chain: B: PDB Molecule:m11l protein;
PDBTitle: crystal structure of m11l, bcl-2 homolog from myxoma virus

Phyre2
8 |
| d1qzpa_ |

### PDB 1qzp chain A

Region: 49 - 60
Aligned: 12
Modelled: 12
Confidence: 6.8%
Identity: 25%
Fold: VHP, Villin headpiece domain
Superfamily: VHP, Villin headpiece domain
Family: VHP, Villin headpiece domain

Phyre2
9 |
| d1yu5x1 |

### PDB 1yu5 chain X domain 1

Region: 49 - 60
Aligned: 12
Modelled: 12
Confidence: 6.3%
Identity: 33%
Fold: VHP, Villin headpiece domain
Superfamily: VHP, Villin headpiece domain
Family: VHP, Villin headpiece domain

Phyre2
10 |
| c2l3xA_ |

### PDB 2l3x chain A

Region: 49 - 60
Aligned: 12
Modelled: 12
Confidence: 6.2%
Identity: 25%
PDB header:protein binding
Chain: A: PDB Molecule:ablim2 protein;
PDBTitle: villin head piece domain of human ablim2

Phyre2
11 |
| d1r5ra_ |

### PDB 1r5r chain A

Region: 32 - 60
Aligned: 29
Modelled: 29
Confidence: 6.1%
Identity: 7%
Fold: EF Hand-like
Superfamily: Insect pheromone/odorant-binding proteins
Family: Insect pheromone/odorant-binding proteins

Phyre2
12 |
| d1ooha_ |

### PDB 1ooh chain A

Region: 31 - 59
Aligned: 29
Modelled: 29
Confidence: 5.5%
Identity: 28%
Fold: EF Hand-like
Superfamily: Insect pheromone/odorant-binding proteins
Family: Insect pheromone/odorant-binding proteins

Phyre2
13 |
| d1wgla_ |

### PDB 1wgl chain A

Region: 35 - 77
Aligned: 40
Modelled: 43
Confidence: 5.4%
Identity: 13%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: CUE domain

Phyre2
14 |
| d1ivsa1 |

### PDB 1ivs chain A domain 1

Region: 58 - 93
Aligned: 36
Modelled: 36
Confidence: 5.3%
Identity: 11%
Fold: Long alpha-hairpin
Superfamily: tRNA-binding arm
Family: Valyl-tRNA synthetase (ValRS) C-terminal domain

Phyre2
15 |
| d1unca_ |

### PDB 1unc chain A

Region: 51 - 60
Aligned: 10
Modelled: 10
Confidence: 5.3%
Identity: 30%
Fold: VHP, Villin headpiece domain
Superfamily: VHP, Villin headpiece domain
Family: VHP, Villin headpiece domain

Phyre2
16 |
| d1yu8x1 |

### PDB 1yu8 chain X domain 1

Region: 51 - 60
Aligned: 10
Modelled: 10
Confidence: 5.2%
Identity: 40%
Fold: VHP, Villin headpiece domain
Superfamily: VHP, Villin headpiece domain
Family: VHP, Villin headpiece domain

Phyre2

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c2dhyA_ |
|  | 21.5 | 9 | PDB header:immune system Chain: A: PDB Molecule:cue domain-containing protein 1; PDBTitle: solution structure of the cue domain in the human cue2 domain containing protein 1 (cuedc1)
2 | c3fpjA_ |
|  | 11.5 | 11 | PDB header:biosynthetic protein, transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of e81q mutant of mtnas in complex with s-2 adenosylmethionine
3 | c2d1lA_ |
|  | 8.9 | 27 | PDB header:protein binding Chain: A: PDB Molecule:metastasis suppressor protein 1; PDBTitle: structure of f-actin binding domain imd of mim (missing in metastasis)
4 | d1unda_ |
|  | 7.9 | 18 | Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain
5 | c3q8iA_ |
|  | 7.3 | 21 | PDB header:odorant binding protein Chain: A: PDB Molecule:odorant binding protein; PDBTitle: crystal structure of anopheles gambiae odorant binding protein 4 in2 complex with indole
6 | c2k6nA_ |
|  | 7.1 | 33 | PDB header:structural protein Chain: A: PDB Molecule:supervillin; PDBTitle: solution structure of human supervillin headpiece, minimized2 average
7 | c2o42B_ |
|  | 7.0 | 31 | PDB header:apoptosis inhibitor Chain: B: PDB Molecule:m11l protein; PDBTitle: crystal structure of m11l, bcl-2 homolog from myxoma virus
8 | d1qzpa_ |
|  | 6.8 | 25 | Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain
9 | d1yu5x1 |
|  | 6.3 | 33 | Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain
10 | c2l3xA_ |
|  | 6.2 | 25 | PDB header:protein binding Chain: A: PDB Molecule:ablim2 protein; PDBTitle: villin head piece domain of human ablim2
11 | d1r5ra_ |
|  | 6.1 | 7 | Fold:EF Hand-like Superfamily:Insect pheromone/odorant-binding proteins Family:Insect pheromone/odorant-binding proteins
12 | d1ooha_ |
|  | 5.5 | 28 | Fold:EF Hand-like Superfamily:Insect pheromone/odorant-binding proteins Family:Insect pheromone/odorant-binding proteins
13 | d1wgla_ |
|  | 5.4 | 13 | Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:CUE domain
14 | d1ivsa1 |
|  | 5.3 | 11 | Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Valyl-tRNA synthetase (ValRS) C-terminal domain
15 | d1unca_ |
|  | 5.3 | 30 | Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain
16 | d1yu8x1 |
|  | 5.2 | 40 | Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0