Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	P	T	T	L	L	L	I	F	T	F	F	A	M	P	G	I	V	Y	A	E	S	P	F	S	S	L	Q	S	A	K	E	K	T	T	V	L	Q	D	L	R	K	I	C	T	P	Q	A	S	L	S	D	E	A	W	E	K	L	M
Secondary structure
SS confidence
Disorder		?	?	?													?	?		?	?	?		?		?	?																					?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		L	S	D	E	N	N	K	Q	H	I	R	E	A	I	V	A	M	E	R	N	N	Q	S	N	Y	W	E	A	L	G	K	V	E	C	P	D	M
Secondary structure
SS confidence
Disorder																			?	?	?	?										?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2dhy chain A Region: 35 - 84 Aligned: 47 Modelled: 50 Confidence: 21.5% Identity: 9% PDB header:immune system Chain: A: PDB Molecule:cue domain-containing protein 1; PDBTitle: solution structure of the cue domain in the human cue2 domain containing protein 1 (cuedc1) Phyre2 PDB 3fpj chain A Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 11.5% Identity: 11% PDB header:biosynthetic protein, transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of e81q mutant of mtnas in complex with s-2 adenosylmethionine Phyre2 PDB 2d1l chain A Region: 35 - 92 Aligned: 45 Modelled: 53 Confidence: 8.9% Identity: 27% PDB header:protein binding Chain: A: PDB Molecule:metastasis suppressor protein 1; PDBTitle: structure of f-actin binding domain imd of mim (missing in metastasis) Phyre2 PDB 1und chain A Region: 50 - 60 Aligned: 11 Modelled: 11 Confidence: 7.9% Identity: 18% Fold: VHP, Villin headpiece domain Superfamily: VHP, Villin headpiece domain Family: VHP, Villin headpiece domain Phyre2 PDB 3q8i chain A Region: 32 - 60 Aligned: 29 Modelled: 29 Confidence: 7.3% Identity: 21% PDB header:odorant binding protein Chain: A: PDB Molecule:odorant binding protein; PDBTitle: crystal structure of anopheles gambiae odorant binding protein 4 in2 complex with indole Phyre2 PDB 2k6n chain A Region: 49 - 60 Aligned: 12 Modelled: 12 Confidence: 7.1% Identity: 33% PDB header:structural protein Chain: A: PDB Molecule:supervillin; PDBTitle: solution structure of human supervillin headpiece, minimized2 average Phyre2 PDB 2o42 chain B Region: 33 - 45 Aligned: 13 Modelled: 13 Confidence: 7.0% Identity: 31% PDB header:apoptosis inhibitor Chain: B: PDB Molecule:m11l protein; PDBTitle: crystal structure of m11l, bcl-2 homolog from myxoma virus Phyre2 PDB 1qzp chain A Region: 49 - 60 Aligned: 12 Modelled: 12 Confidence: 6.8% Identity: 25% Fold: VHP, Villin headpiece domain Superfamily: VHP, Villin headpiece domain Family: VHP, Villin headpiece domain Phyre2 PDB 1yu5 chain X domain 1 Region: 49 - 60 Aligned: 12 Modelled: 12 Confidence: 6.3% Identity: 33% Fold: VHP, Villin headpiece domain Superfamily: VHP, Villin headpiece domain Family: VHP, Villin headpiece domain Phyre2 PDB 2l3x chain A Region: 49 - 60 Aligned: 12 Modelled: 12 Confidence: 6.2% Identity: 25% PDB header:protein binding Chain: A: PDB Molecule:ablim2 protein; PDBTitle: villin head piece domain of human ablim2 Phyre2 PDB 1r5r chain A Region: 32 - 60 Aligned: 29 Modelled: 29 Confidence: 6.1% Identity: 7% Fold: EF Hand-like Superfamily: Insect pheromone/odorant-binding proteins Family: Insect pheromone/odorant-binding proteins Phyre2 PDB 1ooh chain A Region: 31 - 59 Aligned: 29 Modelled: 29 Confidence: 5.5% Identity: 28% Fold: EF Hand-like Superfamily: Insect pheromone/odorant-binding proteins Family: Insect pheromone/odorant-binding proteins Phyre2 PDB 1wgl chain A Region: 35 - 77 Aligned: 40 Modelled: 43 Confidence: 5.4% Identity: 13% Fold: RuvA C-terminal domain-like Superfamily: UBA-like Family: CUE domain Phyre2 PDB 1ivs chain A domain 1 Region: 58 - 93 Aligned: 36 Modelled: 36 Confidence: 5.3% Identity: 11% Fold: Long alpha-hairpin Superfamily: tRNA-binding arm Family: Valyl-tRNA synthetase (ValRS) C-terminal domain Phyre2 PDB 1unc chain A Region: 51 - 60 Aligned: 10 Modelled: 10 Confidence: 5.3% Identity: 30% Fold: VHP, Villin headpiece domain Superfamily: VHP, Villin headpiece domain Family: VHP, Villin headpiece domain Phyre2 PDB 1yu8 chain X domain 1 Region: 51 - 60 Aligned: 10 Modelled: 10 Confidence: 5.2% Identity: 40% Fold: VHP, Villin headpiece domain Superfamily: VHP, Villin headpiece domain Family: VHP, Villin headpiece domain Phyre2 1 c2dhyA_ 2 c3fpjA_ 3 c2d1lA_ 4 d1unda_ 5 c3q8iA_ 6 c2k6nA_ 7 c2o42B_ 8 d1qzpa_ 9 d1yu5x1 10 c2l3xA_ 11 d1r5ra_ 12 d1ooha_ 13 d1wgla_ 14 d1ivsa1 15 d1unca_ 16 d1yu8x1

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2dhyA_ 21.5 9 PDB header:immune system Chain: A: PDB Molecule:cue domain-containing protein 1; PDBTitle: solution structure of the cue domain in the human cue2 domain containing protein 1 (cuedc1) 2 c3fpjA_ 11.5 11 PDB header:biosynthetic protein, transferase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of e81q mutant of mtnas in complex with s-2 adenosylmethionine 3 c2d1lA_ 8.9 27 PDB header:protein binding Chain: A: PDB Molecule:metastasis suppressor protein 1; PDBTitle: structure of f-actin binding domain imd of mim (missing in metastasis) 4 d1unda_ 7.9 18 Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain 5 c3q8iA_ 7.3 21 PDB header:odorant binding protein Chain: A: PDB Molecule:odorant binding protein; PDBTitle: crystal structure of anopheles gambiae odorant binding protein 4 in2 complex with indole 6 c2k6nA_ 7.1 33 PDB header:structural protein Chain: A: PDB Molecule:supervillin; PDBTitle: solution structure of human supervillin headpiece, minimized2 average 7 c2o42B_ 7.0 31 PDB header:apoptosis inhibitor Chain: B: PDB Molecule:m11l protein; PDBTitle: crystal structure of m11l, bcl-2 homolog from myxoma virus 8 d1qzpa_ 6.8 25 Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain 9 d1yu5x1 6.3 33 Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain 10 c2l3xA_ 6.2 25 PDB header:protein binding Chain: A: PDB Molecule:ablim2 protein; PDBTitle: villin head piece domain of human ablim2 11 d1r5ra_ 6.1 7 Fold:EF Hand-like Superfamily:Insect pheromone/odorant-binding proteins Family:Insect pheromone/odorant-binding proteins 12 d1ooha_ 5.5 28 Fold:EF Hand-like Superfamily:Insect pheromone/odorant-binding proteins Family:Insect pheromone/odorant-binding proteins 13 d1wgla_ 5.4 13 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:CUE domain 14 d1ivsa1 5.3 11 Fold:Long alpha-hairpin Superfamily:tRNA-binding arm Family:Valyl-tRNA synthetase (ValRS) C-terminal domain 15 d1unca_ 5.3 30 Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain 16 d1yu8x1 5.2 40 Fold:VHP, Villin headpiece domain Superfamily:VHP, Villin headpiece domain Family:VHP, Villin headpiece domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0