Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	K	S	T	L	A	A	M	A	A	V	F	A	L	S	A	L	S	P	A	A	M	A	A	K	G	D	P	H	V	L	L	T	T	S	A	G	N	I	E	L	E	L	D	K	Q	K	A	P	V	S	V	Q	N	F	V	D	Y	V
Secondary structure
SS confidence
Disorder		?															?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	S	G	F	Y	N	N	T	T	F	H	R	V	I	P	G	F	M	I	Q	G	G	G	F	T	E	Q	M	Q	Q	K	K	P	N	P	P	I	K	N	E	A	D	N	G	L	R	N	T	R	G	T	I	A	M	A	R	T	A	D	K
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	S	A	T	S	Q	F	F	I	N	V	A	D	N	A	F	L	D	H	G	Q	R	D	F	G	Y	A	V	F	G	K	V	V	K	G	M	D	V	A	D	K	I	S	Q	V	P	T	H	D	V	G	P	Y	Q	N	V	P	S	K	P
Secondary structure
SS confidence
Disorder		?	?																																											?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190
Sequence		V	V	I	L	S	A	K	V	L	P
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1v9t chain A Region: 25 - 190 Aligned: 166 Modelled: 166 Confidence: 100.0% Identity: 99% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2k7n chain A Region: 19 - 189 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 33% PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase-like 1; PDBTitle: solution structure of the ppil1 bound to a fragment of skip Phyre2 PDB 3s6m chain A Region: 27 - 189 Aligned: 160 Modelled: 163 Confidence: 100.0% Identity: 57% PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: the structure of a peptidyl-prolyl cis-trans isomerase from2 burkholderia pseudomallei Phyre2 PDB 1ihg chain A Region: 16 - 190 Aligned: 164 Modelled: 175 Confidence: 100.0% Identity: 31% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin 40; PDBTitle: bovine cyclophilin 40, monoclinic form Phyre2 PDB 1lop chain A Region: 31 - 189 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 56% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2a2n chain A domain 1 Region: 21 - 188 Aligned: 160 Modelled: 168 Confidence: 100.0% Identity: 34% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2fu0 chain A domain 1 Region: 29 - 188 Aligned: 151 Modelled: 160 Confidence: 100.0% Identity: 30% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 3bo7 chain D Region: 26 - 189 Aligned: 155 Modelled: 164 Confidence: 100.0% Identity: 28% PDB header:isomerase/immunosuppressant Chain: D: PDB Molecule:peptidyl-prolyl cis-trans isomerase cyclophilin-type; PDBTitle: crystal structure of toxoplasma gondii peptidyl-prolyl cis-trans2 isomerase, 541.m00136 Phyre2 PDB 1xwn chain A domain 1 Region: 18 - 189 Aligned: 163 Modelled: 172 Confidence: 100.0% Identity: 33% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2hq6 chain A Region: 18 - 189 Aligned: 162 Modelled: 172 Confidence: 100.0% Identity: 32% PDB header:isomerase Chain: A: PDB Molecule:serologically defined colon cancer antigen 10; PDBTitle: structure of the cyclophilin_cecyp16-like domain of the serologically2 defined colon cancer antigen 10 from homo sapiens Phyre2 PDB 2b71 chain A Region: 23 - 187 Aligned: 156 Modelled: 165 Confidence: 100.0% Identity: 31% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein; PDBTitle: plasmodium yoelii cyclophilin-like protein Phyre2 PDB 2b71 chain A domain 1 Region: 23 - 187 Aligned: 156 Modelled: 165 Confidence: 100.0% Identity: 31% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1zkc chain A domain 1 Region: 30 - 189 Aligned: 152 Modelled: 160 Confidence: 100.0% Identity: 33% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2ok3 chain A domain 1 Region: 30 - 189 Aligned: 152 Modelled: 160 Confidence: 100.0% Identity: 29% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1ihg chain A domain 2 Region: 18 - 190 Aligned: 162 Modelled: 173 Confidence: 100.0% Identity: 30% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1z81 chain A Region: 18 - 189 Aligned: 163 Modelled: 172 Confidence: 100.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin; PDBTitle: crystal structure of cyclophilin from plasmodium yoelii. Phyre2 PDB 1z81 chain A domain 1 Region: 18 - 189 Aligned: 163 Modelled: 172 Confidence: 100.0% Identity: 26% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1w74 chain A Region: 27 - 188 Aligned: 152 Modelled: 162 Confidence: 100.0% Identity: 33% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2qer chain A Region: 29 - 189 Aligned: 152 Modelled: 154 Confidence: 100.0% Identity: 28% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein, putative; PDBTitle: crystal structure of cryptosporidium parvum cyclophilin type peptidyl-2 prolyl cis-trans isomerase cgd2_1660 in the presence of dipeptide3 ala-pro Phyre2 PDB 2he9 chain B Region: 28 - 189 Aligned: 153 Modelled: 162 Confidence: 100.0% Identity: 29% PDB header:isomerase Chain: B: PDB Molecule:nk-tumor recognition protein; PDBTitle: structure of the peptidylprolyl isomerase domain of the2 human nk-tumour recognition protein Phyre2 1 d1v9ta_ 2 c2k7nA_ 3 c3s6mA_ 4 c1ihgA_ 5 d1lopa_ 6 d2a2na1 7 d2fu0a1 8 c3bo7D_ 9 d1xwna1 10 c2hq6A_ 11 c2b71A_ 12 d2b71a1 13 d1zkca1 14 d2ok3a1 15 d1ihga2 16 c1z81A_ 17 d1z81a1 18 d1w74a_ 19 c2qerA_ 20 c2he9B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1v9ta_ 100.0 99 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 2 c2k7nA_ 100.0 33 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase-like 1; PDBTitle: solution structure of the ppil1 bound to a fragment of skip 3 c3s6mA_ 100.0 57 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: the structure of a peptidyl-prolyl cis-trans isomerase from2 burkholderia pseudomallei 4 c1ihgA_ 100.0 31 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin 40; PDBTitle: bovine cyclophilin 40, monoclinic form 5 d1lopa_ 100.0 56 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 6 d2a2na1 100.0 34 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 7 d2fu0a1 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 8 c3bo7D_ 100.0 28 PDB header:isomerase/immunosuppressant Chain: D: PDB Molecule:peptidyl-prolyl cis-trans isomerase cyclophilin-type; PDBTitle: crystal structure of toxoplasma gondii peptidyl-prolyl cis-trans2 isomerase, 541.m00136 9 d1xwna1 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 10 c2hq6A_ 100.0 32 PDB header:isomerase Chain: A: PDB Molecule:serologically defined colon cancer antigen 10; PDBTitle: structure of the cyclophilin_cecyp16-like domain of the serologically2 defined colon cancer antigen 10 from homo sapiens 11 c2b71A_ 100.0 31 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein; PDBTitle: plasmodium yoelii cyclophilin-like protein 12 d2b71a1 100.0 31 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 13 d1zkca1 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 14 d2ok3a1 100.0 29 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 15 d1ihga2 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 16 c1z81A_ 100.0 26 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin; PDBTitle: crystal structure of cyclophilin from plasmodium yoelii. 17 d1z81a1 100.0 26 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 18 d1w74a_ 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 19 c2qerA_ 100.0 28 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein, putative; PDBTitle: crystal structure of cryptosporidium parvum cyclophilin type peptidyl-2 prolyl cis-trans isomerase cgd2_1660 in the presence of dipeptide3 ala-pro 20 c2he9B_ 100.0 29 PDB header:isomerase Chain: B: PDB Molecule:nk-tumor recognition protein; PDBTitle: structure of the peptidylprolyl isomerase domain of the2 human nk-tumour recognition protein 21 c2poyB_ not modelled 100.0 33 PDB header:isomerase/immunosuppressant Chain: B: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans2 isomerase cgd2_4120 in complex with cyclosporin a 22 d1cyna_ not modelled 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 23 d2z6wa1 not modelled 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 24 d1xo7a_ not modelled 100.0 35 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 25 c3k2cA_ not modelled 100.0 30 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase; PDBTitle: crystal structure of peptidyl-prolyl cis-trans isomerase2 from encephalitozoon cuniculi at 1.9 a resolution 26 c3bkpA_ not modelled 100.0 29 PDB header:isomerase Chain: A: PDB Molecule:cyclophilin; PDBTitle: crystal structure of the toxoplasma gondii cyclophilin, 49.m03261 27 d1a33a_ not modelled 100.0 33 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 28 c2ck1A_ not modelled 100.0 31 PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase e; PDBTitle: the structure of oxidised cyclophilin a from s. mansoni 29 d2rmca_ not modelled 100.0 30 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 30 d2igva1 not modelled 100.0 29 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 31 d1qnga_ not modelled 100.0 28 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 32 d2esla1 not modelled 100.0 29 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 33 d1vdna1 not modelled 100.0 28 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 34 c2oseA_ not modelled 100.0 20 PDB header:isomerase Chain: A: PDB Molecule:probable peptidyl-prolyl cis-trans isomerase; PDBTitle: crystal structure of the mimivirus cyclophilin 35 d1w8ma_ not modelled 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 36 d1qoia_ not modelled 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 37 d2r99a1 not modelled 100.0 28 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 38 d1h0pa_ not modelled 100.0 32 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 39 d2cfea1 not modelled 100.0 29 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 40 d2c3ba1 not modelled 100.0 31 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Cyclophilin (peptidylprolyl isomerase) 41 c3kopB_ not modelled 95.5 17 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein with a cyclophilin-like fold2 (yp_831253.1) from arthrobacter sp. fb24 at 1.90 a resolution 42 c2nnzA_ not modelled 94.8 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: solution structure of the hypothetical protein af2241 from2 archaeoglobus fulgidus 43 d1zx8a1 not modelled 78.8 17 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:TM1367-like 44 d3bbda1 not modelled 15.2 10 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:EMG1/NEP1-like 45 d2v3ka1 not modelled 12.2 20 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:EMG1/NEP1-like 46 c2khfA_ not modelled 10.6 36 PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in dpc-micelles 47 c2khgA_ not modelled 9.4 36 PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in tfe 48 c3lkxB_ not modelled 8.5 21 PDB header:chaperone Chain: B: PDB Molecule:nascent polypeptide-associated complex subunit alpha; PDBTitle: human nac dimerization domain 49 c4a1dE_ not modelled 7.0 8 PDB header:ribosome Chain: E: PDB Molecule:rpl6; PDBTitle: t.thermophila 60s ribosomal subunit in complex with initiation2 factor 6. this file contains 26s rrna and proteins of3 molecule 4. 50 c2v3jA_ not modelled 6.1 22 PDB header:ribosomal protein Chain: A: PDB Molecule:essential for mitotic growth 1; PDBTitle: the yeast ribosome synthesis factor emg1 alpha beta knot2 fold methyltransferase 51 c3ipfA_ not modelled 5.6 25 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the q251q8_deshy protein from desulfitobacterium2 hafniense. northeast structural genomics consortium target dhr8c. 52 c3iz5G_ not modelled 5.5 12 PDB header:ribosome Chain: G: PDB Molecule:60s ribosomal protein l6 (l6e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0