Phyre 2 Results for P0AA93

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Email | l.a.kelley@imperial.ac.uk
Description | P0AA93
Date | Thu Jan 5 11:12:15 GMT 2012
Unique Job ID | 4dfabfae8b7a6478

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c2c2aA_
Top template information
PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
Confidence and coverage
Confidence: | 100.0% | Coverage: | 37%
208 residues ( 37% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
362 residues ( 64%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | H | E | I | F | N | M | L | L | A | V | F | D | R | A | A | L | M | L | I | C | L | F | F | L | I | R | I | R | L | F | R | E | L | L | H | K | S | A | H | S | P | K | E | L | L | A | V | T | A | I | F | S | L | F | A | L | F | S | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | W | S | G | V | P | V | E | G | S | L | V | N | V | R | I | I | A | V | M | S | G | G | I | L | F | G | P | W | V | G | I | I | T | G | V | I | A | G | I | H | R | Y | L | I | D | I | G | G | V | T | A | I | P | C | F | I | T | S | I | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | A | G | C | I | S | G | W | I | N | L | K | I | P | K | A | Q | R | W | R | V | G | I | L | G | G | M | L | C | E | T | L | T | M | I | L | V | I | V | W | A | P | T | T | A | L | G | I | D | I | V | S | K | I | G | I | P | M | I | L | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | S | V | C | I | G | F | I | V | L | L | V | Q | S | V | E | G | E | K | E | A | S | A | A | R | Q | A | K | L | A | L | D | I | A | N | K | T | L | P | L | F | R | H | V | N | S | E | S | L | R | K | V | C | E | I | I | R | D | D | I | H
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | A | D | A | V | A | I | T | N | T | D | H | V | L | A | Y | V | G | V | G | E | H | N | Y | Q | N | G | D | D | F | I | S | P | T | T | R | Q | A | M | N | Y | G | K | I | I | I | K | N | N | D | E | A | H | R | T | P | E | I | H | S | M
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  | ? | ? |  |  |  | ? |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360
Sequence |  | L | V | I | P | L | W | E | K | G | V | V | T | G | T | L | K | I | Y | Y | C | H | A | H | Q | I | T | S | S | L | Q | E | M | A | V | G | L | S | Q | I | I | S | T | Q | L | E | V | S | R | A | E | Q | L | R | E | M | A | N | K | A | E
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  | ? | ? |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420
Sequence |  | L | R | A | L | Q | S | K | I | N | P | H | F | L | F | N | A | L | N | A | I | S | S | S | I | R | L | N | P | D | T | A | R | Q | L | I | F | N | L | S | R | Y | L | R | Y | N | I | E | L | K | D | D | E | Q | I | D | I | K | K | E | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  | ? | ? |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480
Sequence |  | Y | Q | I | K | D | Y | I | A | I | E | Q | A | R | F | G | D | K | L | T | V | I | Y | D | I | D | E | E | V | N | C | C | I | P | S | L | L | I | Q | P | L | V | E | N | A | I | V | H | G | I | Q | P | C | K | G | K | G | V | V | T | I
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540
Sequence |  | S | V | A | E | C | G | N | R | V | R | I | A | V | R | D | T | G | H | G | I | D | P | K | V | I | E | R | V | E | A | N | E | M | P | G | N | K | I | G | L | L | N | V | H | H | R | V | K | L | L | Y | G | E | G | L | H | I | R | R | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | .
Sequence |  | E | P | G | T | E | I | A | F | Y | I | P | N | Q | R | T | P | V | A | S | Q | A | T | L | L | L
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c2c2aA_ |

### PDB 2c2a chain A

Region: 347 - 554
Aligned: 208
Modelled: 208
Confidence: 100.0%
Identity: 20%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase;
PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein

Phyre2
2 |
| c2q8fA_ |

### PDB 2q8f chain A

Region: 359 - 564
Aligned: 204
Modelled: 206
Confidence: 100.0%
Identity: 12%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;
PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1

Phyre2
3 |
| c3d2rB_ |

### PDB 3d2r chain B

Region: 359 - 563
Aligned: 205
Modelled: 205
Confidence: 100.0%
Identity: 12%
PDB header:transferase
Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4;
PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp

Phyre2
4 |
| c1y8oA_ |

### PDB 1y8o chain A

Region: 359 - 563
Aligned: 205
Modelled: 205
Confidence: 100.0%
Identity: 11%
PDB header:transferase
Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3;
PDBTitle: crystal structure of the pdk3-l2 complex

Phyre2
5 |
| c3d36B_ |

### PDB 3d36 chain B

Region: 362 - 552
Aligned: 186
Modelled: 191
Confidence: 100.0%
Identity: 19%
PDB header:transferase/transferase inhibitor
Chain: B: PDB Molecule:sporulation kinase b;
PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda

Phyre2
6 |
| c2bu8A_ |

### PDB 2bu8 chain A

Region: 360 - 563
Aligned: 204
Modelled: 204
Confidence: 100.0%
Identity: 12%
PDB header:transferase
Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2;
PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands

Phyre2
7 |
| c1gjvA_ |

### PDB 1gjv chain A

Region: 334 - 557
Aligned: 224
Modelled: 224
Confidence: 100.0%
Identity: 13%
PDB header:transferase
Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase
PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s

Phyre2
8 |
| c3a0rA_ |

### PDB 3a0r chain A

Region: 233 - 556
Aligned: 316
Modelled: 324
Confidence: 100.0%
Identity: 10%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)

Phyre2
9 |
| d2c2aa2 |

### PDB 2c2a chain A domain 2

Region: 408 - 554
Aligned: 147
Modelled: 147
Confidence: 99.9%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
10 |
| c1b3qA_ |

### PDB 1b3q chain A

Region: 370 - 556
Aligned: 181
Modelled: 185
Confidence: 99.9%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:protein (chemotaxis protein chea);
PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase

Phyre2
11 |
| c3a0tA_ |

### PDB 3a0t chain A

Region: 409 - 555
Aligned: 146
Modelled: 147
Confidence: 99.9%
Identity: 14%
PDB header:transferase
Chain: A: PDB Molecule:sensor protein;
PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)

Phyre2
12 |
| d1gkza2 |

### PDB 1gkz chain A domain 2

Region: 414 - 552
Aligned: 139
Modelled: 139
Confidence: 99.9%
Identity: 17%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2
13 |
| d1id0a_ |

### PDB 1id0 chain A

Region: 411 - 553
Aligned: 139
Modelled: 143
Confidence: 99.9%
Identity: 19%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
14 |
| d1jm6a2 |

### PDB 1jm6 chain A domain 2

Region: 414 - 563
Aligned: 150
Modelled: 150
Confidence: 99.9%
Identity: 15%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: alpha-ketoacid dehydrogenase kinase, C-terminal domain

Phyre2
15 |
| c2ch4A_ |

### PDB 2ch4 chain A

Region: 411 - 555
Aligned: 145
Modelled: 145
Confidence: 99.9%
Identity: 19%
PDB header:transferase/chemotaxis
Chain: A: PDB Molecule:chemotaxis protein chea;
PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew

Phyre2
16 |
| d1i58a_ |

### PDB 1i58 chain A

Region: 413 - 552
Aligned: 140
Modelled: 139
Confidence: 99.9%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
17 |
| d1bxda_ |

### PDB 1bxd chain A

Region: 408 - 562
Aligned: 147
Modelled: 155
Confidence: 99.9%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
18 |
| d1ysra1 |

### PDB 1ysr chain A domain 1

Region: 410 - 552
Aligned: 134
Modelled: 142
Confidence: 99.9%
Identity: 21%
Fold: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Superfamily: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
Family: Histidine kinase

Phyre2
19 |
| c3jz3B_ |

### PDB 3jz3 chain B

Region: 384 - 552
Aligned: 145
Modelled: 150
Confidence: 99.9%
Identity: 21%
PDB header:transferase
Chain: B: PDB Molecule:sensor protein qsec;
PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec

Phyre2
20 |
| c3gieA_ |

### PDB 3gie chain A

Region: 338 - 551
Aligned: 192
Modelled: 197
Confidence: 99.8%
Identity: 17%
PDB header:transferase
Chain: A: PDB Molecule:sensor histidine kinase desk;
PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp

Phyre2
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
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37 |
38 |
39 |
40 |
41 |
42 |
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68 |
69 |
70 |
71 |
72 |
73 |
74 |
75 |
76 |
77 |
78 |
79 |
80 |
81 |
| c1vhmB_ |

### PDB 1vhm chain B

Region: 203 - 351
Aligned: 149
Modelled: 149
Confidence: 94.2%
Identity: 12%
PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:protein yebr;
PDBTitle: crystal structure of an hypothetical protein

Phyre2
82 |
83 |
84 |
85 |
86 |
87 |
88 |
89 |
90 |
91 |
92 |
93 |
94 |
95 |
96 |
97 |
98 |
99 |
100 |
101 |
102 |
103 |
| c3mf0A_ |

### PDB 3mf0 chain A

Region: 171 - 357
Aligned: 187
Modelled: 187
Confidence: 80.0%
Identity: 9%
PDB header:hydrolase
Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase;
PDBTitle: crystal structure of pde5a gaf domain (89-518)

Phyre2
104 |
105 |
106 |
107 |
108 |
109 |
110 |
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136 |

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c2c2aA_ |
|  | 100.0 | 20 | PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: structure of the entire cytoplasmic portion of a sensor2 histidine kinase protein
2 | c2q8fA_ |
|  | 100.0 | 12 | PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 1; PDBTitle: structure of pyruvate dehydrogenase kinase isoform 1
3 | c3d2rB_ |
|  | 100.0 | 12 | PDB header:transferase Chain: B: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 4; PDBTitle: crystal structure of pyruvate dehydrogenase kinase isoform 4 in2 complex with adp
4 | c1y8oA_ |
|  | 100.0 | 11 | PDB header:transferase Chain: A: PDB Molecule:[pyruvate dehydrogenase [lipoamide]] kinase isozyme 3; PDBTitle: crystal structure of the pdk3-l2 complex
5 | c3d36B_ |
|  | 100.0 | 19 | PDB header:transferase/transferase inhibitor Chain: B: PDB Molecule:sporulation kinase b; PDBTitle: how to switch off a histidine kinase: crystal structure of2 geobacillus stearothermophilus kinb with the inhibitor sda
6 | c2bu8A_ |
|  | 100.0 | 12 | PDB header:transferase Chain: A: PDB Molecule:pyruvate dehydrogenase kinase isoenzyme 2; PDBTitle: crystal structures of human pyruvate dehydrogenase kinase 22 containing physiological and synthetic ligands
7 | c1gjvA_ |
|  | 100.0 | 13 | PDB header:transferase Chain: A: PDB Molecule:[3-methyl-2-oxobutanoate dehydrogenase PDBTitle: branched-chain alpha-ketoacid dehydrogenase kinase (bck)2 complxed with atp-gamma-s
8 | c3a0rA_ |
|  | 100.0 | 10 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of histidine kinase thka (tm1359) in complex with2 response regulator protein trra (tm1360)
9 | d2c2aa2 |
|  | 99.9 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
10 | c1b3qA_ |
|  | 99.9 | 17 | PDB header:transferase Chain: A: PDB Molecule:protein (chemotaxis protein chea); PDBTitle: crystal structure of chea-289, a signal transducing histidine kinase
11 | c3a0tA_ |
|  | 99.9 | 14 | PDB header:transferase Chain: A: PDB Molecule:sensor protein; PDBTitle: catalytic domain of histidine kinase thka (tm1359) in2 complex with adp and mg ion (trigonal)
12 | d1gkza2 |
|  | 99.9 | 17 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
13 | d1id0a_ |
|  | 99.9 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
14 | d1jm6a2 |
|  | 99.9 | 15 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
15 | c2ch4A_ |
|  | 99.9 | 19 | PDB header:transferase/chemotaxis Chain: A: PDB Molecule:chemotaxis protein chea; PDBTitle: complex between bacterial chemotaxis histidine kinase chea2 domains p4 and p5 and receptor-adaptor protein chew
16 | d1i58a_ |
|  | 99.9 | 21 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
17 | d1bxda_ |
|  | 99.9 | 21 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
18 | d1ysra1 |
|  | 99.9 | 21 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
19 | c3jz3B_ |
|  | 99.9 | 21 | PDB header:transferase Chain: B: PDB Molecule:sensor protein qsec; PDBTitle: structure of the cytoplasmic segment of histidine kinase qsec
20 | c3gieA_ |
|  | 99.8 | 17 | PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase desk; PDBTitle: crystal structure of deskc_h188e in complex with amp-pcp
21 | d1r62a_ |
| not modelled | 99.8 | 20 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
22 | c3ehgA_ |
| not modelled | 99.7 | 20 | PDB header:transferase Chain: A: PDB Molecule:sensor kinase (yocf protein); PDBTitle: crystal structure of the atp-binding domain of desk in complex with2 atp
23 | c3zxqA_ |
| not modelled | 99.6 | 21 | PDB header:transferase Chain: A: PDB Molecule:hypoxia sensor histidine kinase response regulator dost; PDBTitle: crystal structure of the atp-binding domain of mycobacterium2 tuberculosis dost
24 | d2hkja3 |
| not modelled | 99.6 | 12 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
25 | c3zxoB_ |
| not modelled | 99.5 | 20 | PDB header:transferase Chain: B: PDB Molecule:redox sensor histidine kinase response regulator devs; PDBTitle: crystal structure of the mutant atp-binding domain of2 mycobacterium tuberculosis doss
26 | d1ixma_ |
| not modelled | 99.5 | 12 | Fold:Sporulation response regulatory protein Spo0B Superfamily:Sporulation response regulatory protein Spo0B Family:Sporulation response regulatory protein Spo0B
27 | c2zbkB_ |
| not modelled | 99.5 | 14 | PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of an intact type ii dna topoisomerase:2 insights into dna transfer mechanisms
28 | c1mx0D_ |
| not modelled | 99.4 | 13 | PDB header:isomerase Chain: D: PDB Molecule:type ii dna topoisomerase vi subunit b; PDBTitle: structure of topoisomerase subunit
29 | c2q2eB_ |
| not modelled | 99.4 | 17 | PDB header:isomerase Chain: B: PDB Molecule:type 2 dna topoisomerase 6 subunit b; PDBTitle: crystal structure of the topoisomerase vi holoenzyme from2 methanosarcina mazei
30 | d1th8a_ |
| not modelled | 99.4 | 23 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Histidine kinase
31 | d1y8oa2 |
| not modelled | 99.3 | 13 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:alpha-ketoacid dehydrogenase kinase, C-terminal domain
32 | d1h7sa2 |
| not modelled | 99.3 | 10 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
33 | d1bkna2 |
| not modelled | 99.2 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
34 | d1b63a2 |
| not modelled | 99.0 | 17 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
35 | c3na3A_ |
| not modelled | 98.5 | 16 | PDB header:protein binding Chain: A: PDB Molecule:dna mismatch repair protein mlh1; PDBTitle: mutl protein homolog 1 isoform 1 from homo sapiens
36 | c3h4lB_ |
| not modelled | 98.2 | 19 | PDB header:dna binding protein, protein binding Chain: B: PDB Molecule:dna mismatch repair protein pms1; PDBTitle: crystal structure of n terminal domain of a dna repair protein
37 | c1bknA_ |
| not modelled | 98.1 | 22 | PDB header:dna repair Chain: A: PDB Molecule:mutl; PDBTitle: crystal structure of an n-terminal 40kd fragment of e. coli2 dna mismatch repair protein mutl
38 | c1ea6A_ |
| not modelled | 98.0 | 18 | PDB header:dna repair Chain: A: PDB Molecule:pms1 protein homolog 2; PDBTitle: n-terminal 40kda fragment of nhpms2 complexed with adp
39 | d1ei1a2 |
| not modelled | 98.0 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
40 | d1kija2 |
| not modelled | 97.8 | 15 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
41 | c1y4sA_ |
| not modelled | 97.8 | 16 | PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: conformation rearrangement of heat shock protein 90 upon2 adp binding
42 | d1pvga2 |
| not modelled | 97.7 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
43 | d2iwxa1 |
| not modelled | 97.7 | 14 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
44 | d2c2aa1 |
| not modelled | 97.7 | 23 | Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase
45 | c2o1uA_ |
| not modelled | 97.6 | 17 | PDB header:chaperone Chain: A: PDB Molecule:endoplasmin; PDBTitle: structure of full length grp94 with amp-pnp bound
46 | c1zwhA_ |
| not modelled | 97.6 | 14 | PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: yeast hsp82 in complex with the novel hsp90 inhibitor radester amine
47 | c3ke6A_ |
| not modelled | 97.6 | 32 | PDB header:unknown function Chain: A: PDB Molecule:protein rv1364c/mt1410; PDBTitle: the crystal structure of the rsbu and rsbw domains of rv1364c from2 mycobacterium tuberculosis
48 | c1ei1B_ |
| not modelled | 97.5 | 20 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase b; PDBTitle: dimerization of e. coli dna gyrase b provides a structural mechanism2 for activating the atpase catalytic center
49 | d1s16a2 |
| not modelled | 97.5 | 19 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
50 | c1zxnB_ |
| not modelled | 97.5 | 19 | PDB header:isomerase Chain: B: PDB Molecule:dna topoisomerase ii, alpha isozyme; PDBTitle: human dna topoisomerase iia atpase/adp
51 | c2o1wB_ |
| not modelled | 97.5 | 19 | PDB header:chaperone Chain: B: PDB Molecule:endoplasmin; PDBTitle: structure of n-terminal plus middle domains (n+m) of grp94
52 | c1kijB_ |
| not modelled | 97.4 | 14 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: crystal structure of the 43k atpase domain of thermus thermophilus2 gyrase b in complex with novobiocin
53 | c2cg9A_ |
| not modelled | 97.4 | 13 | PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: crystal structure of an hsp90-sba1 closed chaperone complex
54 | c1qzrA_ |
| not modelled | 97.4 | 15 | PDB header:isomerase Chain: A: PDB Molecule:dna topoisomerase ii; PDBTitle: crystal structure of the atpase region of saccharomyces cerevisiae2 topoisomerase ii bound to icrf-187 (dexrazoxane)
55 | c1s16B_ |
| not modelled | 97.4 | 22 | PDB header:isomerase Chain: B: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of e. coli topoisomerase iv pare 43kda subunit2 complexed with adpnp
56 | c3pehB_ |
| not modelled | 97.3 | 14 | PDB header:chaperone Chain: B: PDB Molecule:endoplasmin homolog; PDBTitle: crystal structure of the n-terminal domain of an hsp90 from plasmodium2 falciparum, pfl1070c in the presence of a thienopyrimidine derivative
57 | c2iorA_ |
| not modelled | 97.3 | 18 | PDB header:chaperone Chain: A: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of the n-terminal domain of htpg, the2 escherichia coli hsp90, bound to adp
58 | d1uyla_ |
| not modelled | 97.2 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
59 | c2fwyA_ |
| not modelled | 97.2 | 16 | PDB header:chaperone Chain: A: PDB Molecule:heat shock protein hsp 90-alpha; PDBTitle: structure of human hsp90-alpha bound to the potent water2 soluble inhibitor pu-h64
60 | d1s14a_ |
| not modelled | 97.2 | 18 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:DNA gyrase/MutL, N-terminal domain
61 | c3iedA_ |
| not modelled | 97.2 | 22 | PDB header:chaperone Chain: A: PDB Molecule:heat shock protein; PDBTitle: crystal structure of n-terminal domain of plasmodium falciparum hsp902 (pf14_0417) in complex with amppn
62 | c3g7bB_ |
| not modelled | 97.2 | 21 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase subunit b; PDBTitle: staphylococcus aureus gyrase b co-complex with inhibitor
63 | c2iopD_ |
| not modelled | 97.2 | 15 | PDB header:chaperone Chain: D: PDB Molecule:chaperone protein htpg; PDBTitle: crystal structure of full-length htpg, the escherichia coli2 hsp90, bound to adp
64 | d1uyma_ |
| not modelled | 97.1 | 14 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
65 | d1joya_ |
| not modelled | 97.0 | 25 | Fold:ROP-like Superfamily:Homodimeric domain of signal transducing histidine kinase Family:Homodimeric domain of signal transducing histidine kinase
66 | d2gqpa1 |
| not modelled | 97.0 | 13 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
67 | c3lnuA_ |
| not modelled | 96.9 | 19 | PDB header:isomerase Chain: A: PDB Molecule:topoisomerase iv subunit b; PDBTitle: crystal structure of pare subunit
68 | c2akpA_ |
| not modelled | 96.9 | 18 | PDB header:chaperone Chain: A: PDB Molecule:atp-dependent molecular chaperone hsp82; PDBTitle: hsp90 delta24-n210 mutant
69 | d1qy5a_ |
| not modelled | 96.8 | 16 | Fold:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Superfamily:ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase Family:Heat shock protein 90, HSP90, N-terminal domain
70 | c3zrwB_ |
| not modelled | 96.8 | 22 | PDB header:signaling protein Chain: B: PDB Molecule:af1503 protein, osmolarity sensor protein envz; PDBTitle: the structure of the dimeric hamp-dhp fusion a291v mutant
71 | c2w1tB_ |
| not modelled | 96.7 | 16 | PDB header:transcription Chain: B: PDB Molecule:stage v sporulation protein t; PDBTitle: crystal structure of b. subtilis spovt
72 | c2w1rA_ |
| not modelled | 96.2 | 15 | PDB header:transcription Chain: A: PDB Molecule:stage v sporulation protein t; PDBTitle: crystal structure of the c-terminal domain of b. subtilis2 spovt
73 | d2veaa1 |
| not modelled | 95.7 | 12 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
74 | c2lb5A_ |
| not modelled | 94.6 | 16 | PDB header:transferase Chain: A: PDB Molecule:sensor histidine kinase; PDBTitle: refined structural basis for the photoconversion of a phytochrome to2 the activated far-red light-absorbing form
75 | c2oolA_ |
| not modelled | 94.4 | 11 | PDB header:signaling protein Chain: A: PDB Molecule:sensor protein; PDBTitle: crystal structure of the chromophore-binding domain of an unusual2 bacteriophytochrome rpbphp3 from r. palustris
76 | c3cwvB_ |
| not modelled | 94.4 | 20 | PDB header:isomerase Chain: B: PDB Molecule:dna gyrase, b subunit, truncated; PDBTitle: crystal structure of b-subunit of the dna gyrase from myxococcus2 xanthus
77 | c3mmhA_ |
| not modelled | 94.4 | 17 | PDB header:oxidoreductase Chain: A: PDB Molecule:methionine-r-sulfoxide reductase; PDBTitle: x-ray structure of free methionine-r-sulfoxide reductase from2 neisseria meningitidis in complex with its substrate
78 | c3e0yA_ |
| not modelled | 94.3 | 12 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved domain protein; PDBTitle: the crystal structure of a conserved domain from a protein of2 geobacter sulfurreducens pca
79 | d2o9ca1 |
| not modelled | 94.3 | 17 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
80 | c3k2nB_ |
| not modelled | 94.2 | 16 | PDB header:transcription regulator Chain: B: PDB Molecule:sigma-54-dependent transcriptional regulator; PDBTitle: the crystal structure of sigma-54-dependent transcriptional2 regulator domain from chlorobium tepidum tls
81 | c1vhmB_ |
|  | 94.2 | 12 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein yebr; PDBTitle: crystal structure of an hypothetical protein
82 | c1mc0A_ |
| not modelled | 94.0 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:3',5'-cyclic nucleotide phosphodiesterase 2a; PDBTitle: regulatory segment of mouse 3',5'-cyclic nucleotide phosphodiesterase2 2a, containing the gaf a and gaf b domains
83 | c3p01C_ |
| not modelled | 93.8 | 14 | PDB header:signaling protein Chain: C: PDB Molecule:two-component response regulator; PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120
84 | c3trcA_ |
| not modelled | 93.3 | 22 | PDB header:transferase Chain: A: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: structure of the gaf domain from a phosphoenolpyruvate-protein2 phosphotransferase (ptsp) from coxiella burnetii
85 | d1vhma_ |
| not modelled | 93.3 | 15 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
86 | c3hcyB_ |
| not modelled | 93.1 | 22 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative two-component sensor histidine kinase protein; PDBTitle: the crystal structure of the domain of putative two-component sensor2 histidine kinase protein from sinorhizobium meliloti 1021
87 | d2k2na1 |
| not modelled | 93.1 | 15 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
88 | c2vjwA_ |
| not modelled | 92.8 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:gaf family protein; PDBTitle: crystal structure of the second gaf domain of devs from2 mycobacterium smegmatis
89 | d2oola1 |
| not modelled | 92.1 | 11 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
90 | c3ci6B_ |
| not modelled | 91.9 | 16 | PDB header:transferase Chain: B: PDB Molecule:phosphoenolpyruvate-protein phosphotransferase; PDBTitle: crystal structure of the gaf domain from acinetobacter2 phosphoenolpyruvate-protein phosphotransferase
91 | c3lmmA_ |
| not modelled | 91.7 | 18 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the dip2311 protein from2 corynebacterium diphtheriae, northeast structural genomics3 consortium target cdr35
92 | c2o9bA_ |
| not modelled | 91.4 | 17 | PDB header:transferase Chain: A: PDB Molecule:bacteriophytochrome; PDBTitle: crystal structure of bacteriophytochrome chromophore binding domain
93 | c2zmfA_ |
| not modelled | 90.3 | 10 | PDB header:hydrolase Chain: A: PDB Molecule:camp and camp-inhibited cgmp 3',5'-cyclic phosphodiesterase PDBTitle: crystal structure of the c-terminal gaf domain of human2 phosphodiesterase 10a
94 | c3ksiA_ |
| not modelled | 89.7 | 14 | PDB header:oxidoreductase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: structure of frmsr of staphylococcus aureus (complex with 2-propanol)
95 | c3oovA_ |
| not modelled | 88.1 | 13 | PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein, putative; PDBTitle: crystal structure of a methyl-accepting chemotaxis protein, residues2 122 to 287
96 | c1ykdB_ |
| not modelled | 87.7 | 13 | PDB header:lyase Chain: B: PDB Molecule:adenylate cyclase; PDBTitle: crystal structure of the tandem gaf domains from a cyanobacterial2 adenylyl cyclase: novel modes of ligand-binding and dimerization
97 | c3o5yA_ |
| not modelled | 87.5 | 14 | PDB header:transcription regulator Chain: A: PDB Molecule:sensor protein; PDBTitle: the crystal structure of the gaf domain of a two-component sensor2 histidine kinase from bacillus halodurans to 2.45a
98 | c3eeaB_ |
| not modelled | 84.6 | 6 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:gaf domain/hd domain protein; PDBTitle: the crystal structure of the gaf domain/hd domain protein2 from geobacter sulfurreducens
99 | d1mc0a1 |
| not modelled | 82.9 | 14 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
100 | c3dbaB_ |
| not modelled | 82.6 | 17 | PDB header:hydrolase Chain: B: PDB Molecule:cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit PDBTitle: crystal structure of the cgmp-bound gaf a domain from the2 photoreceptor phosphodiesterase 6c
101 | d1f5ma_ |
| not modelled | 81.7 | 14 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
102 | c2w3gA_ |
| not modelled | 81.5 | 14 | PDB header:transferase Chain: A: PDB Molecule:two component sensor histidine kinase devs (gaf PDBTitle: air-oxidized structure of the first gaf domain of2 mycobacterium tuberculosis doss
103 | c3mf0A_ |
|  | 80.0 | 9 | PDB header:hydrolase Chain: A: PDB Molecule:cgmp-specific 3',5'-cyclic phosphodiesterase; PDBTitle: crystal structure of pde5a gaf domain (89-518)
104 | c2veaA_ |
| not modelled | 79.4 | 10 | PDB header:transferase Chain: A: PDB Molecule:phytochrome-like protein cph1; PDBTitle: the complete sensory module of the cyanobacterial2 phytochrome cph1 in the pr-state.
105 | c3p01A_ |
| not modelled | 74.9 | 15 | PDB header:signaling protein Chain: A: PDB Molecule:two-component response regulator; PDBTitle: crystal structure of two-component response regulator from nostoc sp.2 pcc 7120
106 | d3c2wa1 |
| not modelled | 73.9 | 15 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
107 | d1mc0a2 |
| not modelled | 72.9 | 11 | Fold:Profilin-like Superfamily:GAF domain-like Family:GAF domain
108 | c3ibjB_ |
| not modelled | 69.0 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:cgmp-dependent 3',5'-cyclic phosphodiesterase; PDBTitle: x-ray structure of pde2a
109 | c3c2wB_ |
| not modelled | 64.3 | 14 | PDB header:signaling protein Chain: B: PDB Molecule:bacteriophytochrome; PDBTitle: crystal structure of the photosensory core domain of p.2 aeruginosa bacteriophytochrome pabphp in the pfr state
110 | d1q8ka2 |
| not modelled | 58.6 | 11 | Fold:Ferredoxin-like Superfamily:eIF-2-alpha, C-terminal domain Family:eIF-2-alpha, C-terminal domain
111 | c1yz7A_ |
| not modelled | 52.5 | 17 | PDB header:translation Chain: A: PDB Molecule:probable translation initiation factor 2 alpha PDBTitle: crystal structure of a c-terminal segment of the alpha2 subunit of aif2 from pyrococcus abyssi
112 | c3e98B_ |
| not modelled | 50.2 | 22 | PDB header:unknown function Chain: B: PDB Molecule:gaf domain of unknown function; PDBTitle: crystal structure of a gaf domain containing protein that belongs to2 pfam duf484 family (pa5279) from pseudomonas aeruginosa at 2.43 a3 resolution
113 | c3p5nA_ |
| not modelled | 47.3 | 16 | PDB header:transport protein Chain: A: PDB Molecule:riboflavin uptake protein; PDBTitle: structure and mechanism of the s component of a bacterial ecf2 transporter
114 | c2qybA_ |
| not modelled | 43.8 | 17 | PDB header:membrane protein Chain: A: PDB Molecule:membrane protein, putative; PDBTitle: crystal structure of the gaf domain region of putative membrane2 protein from geobacter sulfurreducens pca
115 | c1yz6A_ |
| not modelled | 42.6 | 16 | PDB header:translation Chain: A: PDB Molecule:probable translation initiation factor 2 alpha PDBTitle: crystal structure of intact alpha subunit of aif2 from2 pyrococcus abyssi
116 | d1j0ga_ |
| not modelled | 41.9 | 22 | Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:BM-002-like
117 | c1ut8B_ |
| not modelled | 39.2 | 30 | PDB header:hydrolase Chain: B: PDB Molecule:exodeoxyribonuclease; PDBTitle: divalent metal ions (zinc) bound to t5 5'-exonuclease
118 | d1b74a1 |
| not modelled | 38.2 | 27 | Fold:ATC-like Superfamily:Aspartate/glutamate racemase Family:Aspartate/glutamate racemase
119 | d1kyfa2 |
| not modelled | 37.7 | 9 | Fold:Subdomain of clathrin and coatomer appendage domain Superfamily:Subdomain of clathrin and coatomer appendage domain Family:Clathrin adaptor appendage, alpha and beta chain-specific domain
120 | c2xssB_ |
| not modelled | 32.2 | 6 | PDB header:hydrolase Chain: B: PDB Molecule:cgmp-specific 3', 5'-cyclic phosphodiesterase; PDBTitle: crystal structure of gafb from the human phosphodiesterase 5

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0