BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (245 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 405 e-112 UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 355 7e-97 UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 285 8e-76 UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 283 3e-75 UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 281 2e-74 UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 248 1e-64 UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 246 5e-64 UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 5e-62 UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 2e-56 UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 8e-54 UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 212 1e-53 UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 209 6e-53 UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 202 1e-50 UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 187 2e-46 UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 186 7e-46 UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 183 3e-45 UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 170 4e-41 UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 169 6e-41 UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 165 1e-39 UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 162 9e-39 UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxa... 161 2e-38 UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 161 2e-38 UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 160 4e-38 UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 158 1e-37 UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 158 2e-37 UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 155 1e-36 UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 155 1e-36 UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 155 2e-36 UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 154 2e-36 UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 154 2e-36 UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 154 3e-36 UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 154 3e-36 UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 153 4e-36 UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 153 4e-36 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 152 7e-36 UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 152 8e-36 UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 152 1e-35 UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 151 2e-35 UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 151 2e-35 UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 150 3e-35 UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxa... 148 1e-34 UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 148 2e-34 UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=... 148 2e-34 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 147 3e-34 UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 147 3e-34 UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxa... 147 4e-34 UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxa... 146 6e-34 UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 145 8e-34 UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spir... 145 9e-34 UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 145 1e-33 UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 145 2e-33 UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 144 3e-33 UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 144 3e-33 UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 144 3e-33 UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 144 4e-33 UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 142 1e-32 UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 142 1e-32 UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 142 1e-32 UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 142 1e-32 UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 141 2e-32 UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 141 2e-32 UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 140 4e-32 UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 139 6e-32 UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 139 6e-32 UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 139 7e-32 UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 139 7e-32 UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxa... 139 8e-32 UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 139 8e-32 UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 139 1e-31 UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 137 3e-31 UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 137 3e-31 UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 137 4e-31 UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 137 4e-31 UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 136 6e-31 UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 135 9e-31 UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collins... 135 1e-30 UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 135 1e-30 UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole ... 135 1e-30 UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 135 1e-30 UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 135 1e-30 UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 135 2e-30 UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 134 4e-30 UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 134 4e-30 UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 134 4e-30 UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 134 4e-30 UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 134 4e-30 UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 133 6e-30 UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 132 8e-30 UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 132 9e-30 UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 132 1e-29 UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 132 1e-29 UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 131 2e-29 UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 130 3e-29 UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 130 3e-29 UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 130 3e-29 UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomyc... 130 5e-29 UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 130 5e-29 UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 129 7e-29 UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 127 4e-28 UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 126 5e-28 UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 125 9e-28 UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanae... 125 2e-27 UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 124 2e-27 UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 124 2e-27 UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 124 2e-27 UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 123 7e-27 UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 122 8e-27 UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 122 2e-26 UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 121 2e-26 UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 120 3e-26 UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 119 1e-25 UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole... 119 1e-25 UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 119 1e-25 UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 116 7e-25 UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicr... 112 1e-23 UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 111 2e-23 UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 109 1e-22 UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 107 3e-22 UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 107 5e-22 UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 104 3e-21 UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 103 5e-21 UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 101 2e-20 UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 99 1e-19 UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 97 4e-19 UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 96 1e-18 UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hi... 92 1e-17 UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanoco... 92 1e-17 UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazol... 92 2e-17 UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hi... 92 2e-17 UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 92 2e-17 UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxa... 91 3e-17 UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 90 7e-17 UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hi... 89 1e-16 UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosyl... 89 1e-16 UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hi... 89 1e-16 UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hi... 87 5e-16 UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hi... 87 7e-16 UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hi... 86 1e-15 UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 86 1e-15 UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hi... 86 1e-15 UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase s... 86 1e-15 UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 85 2e-15 UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxa... 84 3e-15 UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 83 9e-15 UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxa... 83 9e-15 UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hi... 82 1e-14 UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hi... 82 2e-14 UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanae... 81 4e-14 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 80 7e-14 UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3... 79 2e-13 UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase su... 78 2e-13 UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hi... 78 3e-13 UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hi... 78 3e-13 UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter... 77 3e-13 UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hi... 77 4e-13 UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hi... 77 4e-13 UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirg... 77 6e-13 UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococ... 76 8e-13 UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hi... 76 8e-13 UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hi... 76 9e-13 UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillon... 75 1e-12 UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hi... 75 1e-12 UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hi... 75 2e-12 UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 74 3e-12 UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hi... 74 5e-12 UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfati... 74 6e-12 UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, c... 74 6e-12 UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picr... 72 1e-11 UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 T... 72 2e-11 UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria ... 71 3e-11 UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase su... 71 3e-11 UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hi... 71 4e-11 UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methano... 70 8e-11 UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase s... 70 9e-11 UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winog... 69 1e-10 UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Pro... 69 1e-10 UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase su... 67 4e-10 UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hi... 67 5e-10 UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 66 1e-09 UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID... 65 1e-09 UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase s... 65 2e-09 UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hah... 65 2e-09 UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hi... 65 3e-09 UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 65 3e-09 UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Pro... 64 4e-09 UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hi... 64 4e-09 UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 4e-09 UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 64 4e-09 UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Pr... 64 5e-09 UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovi... 63 7e-09 UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hi... 63 9e-09 UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovi... 63 1e-08 UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobact... 61 3e-08 UniRef50_P72139 Putative imidazole glycerol phosphate synthase s... 61 4e-08 UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase su... 59 1e-07 UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 59 1e-07 UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase su... 59 2e-07 UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase s... 59 2e-07 UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter... 58 3e-07 UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Me... 57 4e-07 UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase s... 57 6e-07 UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase Hi... 57 6e-07 UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hi... 56 1e-06 UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlo... 56 1e-06 UniRef50_D2MIW0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 55 2e-06 UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit Hi... 55 3e-06 UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii H... 54 6e-06 UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase su... 53 8e-06 UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase s... 52 2e-05 UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase s... 52 3e-05 UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxa... 51 3e-05 UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methano... 51 3e-05 UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit Hi... 50 8e-05 UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlo... 49 1e-04 UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C... 49 2e-04 UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms Re... 48 2e-04 UniRef50_B1LZS6 Histidine biosynthesis protein n=10 Tax=Alphapro... 48 3e-04 UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlo... 47 4e-04 UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxa... 47 5e-04 UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis... 47 5e-04 UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oce... 47 8e-04 UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hi... 46 0.001 UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepI... 45 0.002 UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacte... 45 0.002 UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_Y... 45 0.002 UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlo... 44 0.007 UniRef50_A3HVC3 PcrB-like protein n=1 Tax=Algoriphagus sp. PR1 R... 43 0.010 UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hi... 43 0.012 UniRef50_B8EIK2 Histidine biosynthesis protein n=2 Tax=Beijerinc... 42 0.014 UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanoco... 42 0.016 UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planc... 42 0.018 UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit H... 42 0.018 UniRef50_Q2RGX5 Ferredoxin-dependent glutamate synthase n=2 Tax=... 40 0.063 UniRef50_O82782 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 40 0.075 >UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=97 Tax=Gammaproteobacteria RepID=HIS4_YERP3 Length = 245 Score = 405 bits (1040), Expect = e-112, Method: Compositional matrix adjust. Identities = 194/244 (79%), Positives = 221/244 (90%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALDLI+G VVRLHQGDYG+QRDYGN PLPRLQDY QGA+VLHLVDLTGAKDPA R Sbjct: 1 MIIPALDLIEGKVVRLHQGDYGQQRDYGNHPLPRLQDYQQQGAQVLHLVDLTGAKDPAAR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 QIPL++ L+AGV+VPVQVGGG+R+E+DV ALLEAG ARVVVGSTAVK +MV+ WFER+G Sbjct: 61 QIPLLRELLAGVDVPVQVGGGIRNEQDVVALLEAGAARVVVGSTAVKQPEMVQQWFERYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+A+VLALDVRI+E G K VA+SGWQENS +LEQ+VE YLP GLKHVLCTDISRDGTL+ Sbjct: 121 AEAIVLALDVRINEAGCKHVAISGWQENSDATLEQIVEQYLPYGLKHVLCTDISRDGTLS 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 GSNV LY+EVC RYPQVAFQ+SGGIG +DD+A LRG+GV+GVIVGRALL+GKF VKEAIA Sbjct: 181 GSNVELYQEVCQRYPQVAFQASGGIGCLDDIARLRGSGVQGVIVGRALLDGKFNVKEAIA 240 Query: 241 CWQN 244 CWQN Sbjct: 241 CWQN 244 >UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=92 Tax=Proteobacteria RepID=HIS4_ACTP2 Length = 250 Score = 355 bits (911), Expect = 7e-97, Method: Compositional matrix adjust. Identities = 169/244 (69%), Positives = 199/244 (81%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPALDLIDG VVRLHQGDY KQ Y ++P+ + +Y AQGAE LHLVDLTGAK PAKR Sbjct: 6 IIIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFANYLAQGAEQLHLVDLTGAKYPAKR 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI ++A N +QVGGG+R+E+DVA LL G RVV+GSTAVK + MVKGWFE++G Sbjct: 66 QTALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYG 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ VLALDV ID G K +A+SGWQE SGVSLE+L+E Y VGL+HVLCTDISRDGTLA Sbjct: 126 AEKFVLALDVNIDASGQKIIAISGWQEASGVSLEELIEDYQVVGLQHVLCTDISRDGTLA 185 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 GSNV+LY E+CA+YP++ FQSSGGIG +DD+ AL+GTGV GVIVGRALLEGKF V EAI Sbjct: 186 GSNVNLYREICAKYPKIHFQSSGGIGSLDDIKALKGTGVSGVIVGRALLEGKFNVAEAIE 245 Query: 241 CWQN 244 CWQN Sbjct: 246 CWQN 249 >UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Gammaproteobacteria RepID=HIS4_SHEDO Length = 250 Score = 285 bits (730), Expect = 8e-76, Method: Compositional matrix adjust. Identities = 142/250 (56%), Positives = 182/250 (72%), Gaps = 5/250 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPA+DLIDG VVRL+QGDY KQ + PL +L+ Y QGA++LH+VDLTGAKDP +R Sbjct: 1 MIIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLKSYQDQGAKLLHIVDLTGAKDPNQR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 QI LI LVAG++V +QVGGG+RSE+ V LL GV RVV+GS AVK ++VK W ++G Sbjct: 61 QIKLISELVAGLDVDIQVGGGIRSEQQVTELLAIGVKRVVIGSLAVKEPELVKSWLNKYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVG-----LKHVLCTDISR 175 +DA+ LALDV I+ G K VAVSGWQ G +LE LV + G LKH L TDISR Sbjct: 121 SDAICLALDVNINANGEKIVAVSGWQSAGGKTLESLVAEFERPGSKQTALKHALVTDISR 180 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGTL G+N +LY E+ A YP + +Q+SGGI +DDV+A++ + G+I+G+ALL +FTV Sbjct: 181 DGTLTGANTALYTELAAAYPTILWQASGGIATLDDVSAVKDSKAAGIIIGKALLINQFTV 240 Query: 236 KEAIACWQNA 245 +EAI CW NA Sbjct: 241 EEAIQCWPNA 250 >UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Alteromonadales RepID=HIS4_COLP3 Length = 261 Score = 283 bits (725), Expect = 3e-75, Method: Compositional matrix adjust. Identities = 137/242 (56%), Positives = 178/242 (73%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IPA+DLI G VVRL+QGDY ++ +Y R Q YA GA V+H VDL GAKD KR Sbjct: 1 MMIPAIDLIGGEVVRLYQGDYAQKTNYQYTVQDRQQAYAESGATVMHFVDLDGAKDSTKR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ +KT+V ++ +QVGGGVR E+DV LL G RVV+GS A+K ++V W + +G Sbjct: 61 QLKTLKTVVNHPSMIIQVGGGVRCEDDVKQLLALGADRVVIGSLAIKQPELVTQWVKTYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VLALD++ID QGNK + GW E+SGV+LE L+ Y G+KHVLCTDIS+DGTL Sbjct: 121 CEKIVLALDIKIDAQGNKTLPTHGWIEDSGVNLEDLLAQYQDAGIKHVLCTDISKDGTLT 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+NV LY EVCA+YP + +Q+SGGIG + D+ AL TGV GVI+GR+LLEGKFT++EAIA Sbjct: 181 GTNVDLYSEVCAKYPDIDWQASGGIGSLADIKALIPTGVSGVILGRSLLEGKFTLEEAIA 240 Query: 241 CW 242 CW Sbjct: 241 CW 242 >UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=117 Tax=Enterobacteriaceae RepID=HIS4_BLOFL Length = 251 Score = 281 bits (718), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 124/248 (50%), Positives = 175/248 (70%), Gaps = 4/248 (1%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALD+I+G VRL+QG Y Q YGN P L Y QGA ++HLVDL GA++P R Sbjct: 1 MIIPALDIINGDAVRLYQGKYQSQSHYGN-PYSILSTYVQQGATMIHLVDLDGARNPKNR 59 Query: 61 QIPLIKTLVAGV---NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 Q+ LIK L ++ +Q+GGG+R D+ LL+ GV RV++GS A+ VK WF Sbjct: 60 QLSLIKELTHTAITSHLKIQIGGGIRHATDIKTLLKFGVNRVILGSIAITHPKKVKQWFT 119 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 F +LVLALD+ ID + N++V + GWQ+ + + LE+++E Y VGLKHVLCTDIS+DG Sbjct: 120 YFNPSSLVLALDIYIDSKNNRKVVIHGWQKETNIQLEEVIENYNSVGLKHVLCTDISKDG 179 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 TL GSN++LY+ +C ++P+++FQ+SGG+ + ++ LR +GV +I+GR+ LE KFT+ E Sbjct: 180 TLLGSNINLYQSICYKWPKISFQASGGVAKLTEILQLRSSGVNSIIIGRSFLEKKFTLTE 239 Query: 238 AIACWQNA 245 AI+CWQNA Sbjct: 240 AISCWQNA 247 >UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=16 Tax=Campylobacter RepID=HIS4_CAMJD Length = 244 Score = 248 bits (633), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 125/244 (51%), Positives = 175/244 (71%), Gaps = 3/244 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPALDLIDG VVRL +GDY +++ Y +PL + ++Y GA+ LHLVDLTGAKDP+KRQ Sbjct: 4 IIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQ 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI+ L V+V +QVGGG+RS+E+V ALL+ GV RVV+GS A+K + ++FG+ Sbjct: 64 LVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGS 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +A+VLALD + E + VAV+ WQE S L ++++ Y GLKH+LCTDIS+DGT+ G Sbjct: 124 EAIVLALDTILKE--DYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV LY+ + +P++ Q+SGG+ + D+ L+G GVIVG+ALL+G F+V+E I C Sbjct: 182 VNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGI-CSGVIVGKALLDGVFSVEEGIRC 240 Query: 242 WQNA 245 QNA Sbjct: 241 LQNA 244 >UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=HIS4_BUCCC Length = 245 Score = 246 bits (628), Expect = 5e-64, Method: Compositional matrix adjust. Identities = 103/242 (42%), Positives = 157/242 (64%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP+LD I G +VRL+QG+Y + Y D +++ Y QGA +HLVDL G +P R Sbjct: 1 MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q + NV QVGGG+RS+ D+ L AGV+++V+G++A+ + K W + +G Sbjct: 61 QKSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + VL++D+ I+ + ++A+ GW++ + ++L+ ++ ++P GLK++LCTDISRDGT + Sbjct: 121 SKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILCTDISRDGTFS 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+SLY+ + ++P + QSSGGI I D+ L+ V VIVGRALLE KFT EA Sbjct: 181 GPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK 240 Query: 241 CW 242 CW Sbjct: 241 CW 242 >UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=HIS4_BUCBP Length = 241 Score = 239 bits (611), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 112/241 (46%), Positives = 161/241 (66%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP++DLI+G +VRL+QG+Y + Y N+ Y QGA+++HLVDL GA P + Sbjct: 1 MIIPSIDLIEGNIVRLYQGNYDTKTFYQNNIYDIALKYYNQGAKIVHLVDLDGALCPNNK 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LIK L+ N +QVGGG+RS +DV LL G RVV+GS+A+ + V+ W FG Sbjct: 61 QTSLIKNLLNYFNFHIQVGGGIRSYKDVETLLLNGAKRVVIGSSAINNITEVEKWLLEFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++VLALDV + G K+V ++GW+ S VSLE ++E + +G+K+VLCTD+ +DGT Sbjct: 121 YKSIVLALDVYVRNNGYKEVVINGWKNRSNVSLESVLERFSTLGIKYVLCTDVKKDGTCL 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N +LY+ + + V FQ SGGIG I DV + + +G++ +I+GRALLE KF++ EAI Sbjct: 181 GPNFTLYKNISKLFKNVCFQLSGGIGTISDVISAKKSGIKDIIIGRALLENKFSLLEAIR 240 Query: 241 C 241 C Sbjct: 241 C 241 >UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_FRAP2 Length = 241 Score = 221 bits (563), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 112/240 (46%), Positives = 156/240 (65%), Gaps = 1/240 (0%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DLI+G VRL +GD+ K Y +P + Y GAE +H+VDL GAK Q Sbjct: 3 IFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQTCQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ + N+ +QVGGGV+ E + LLE GV RVV+GS AVK + K +FE++GA Sbjct: 63 FETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKYGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +VLALDV I + G +A GWQE+S +L+++++TYL GL++VLCTDISRDG L G Sbjct: 123 EKIVLALDVFI-KNGVPYIATHGWQESSTTTLDEILQTYLGDGLEYVLCTDISRDGMLQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N LY + YP V F +SGG+G ++D+ L+ GVI+G+AL E KFT++EA+ C Sbjct: 182 PNFELYRIYSSIYPDVQFMASGGVGSLEDLEILKEQNTYGVIIGKALYENKFTLQEALEC 241 >UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alteromonadales RepID=HIS4_PSEHT Length = 242 Score = 212 bits (540), Expect = 8e-54, Method: Compositional matrix adjust. Identities = 108/240 (45%), Positives = 158/240 (65%), Gaps = 1/240 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALD++ +VRL+QG Y + Y + RL++YA GA LHLVDL GA+DP+K+ Sbjct: 1 MIIPALDVLQNQIVRLYQGKYETVQFYPFELGARLKEYADSGAGKLHLVDLEGARDPSKK 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q I+ +NVP QVGGG+R E+DV+ L+AG +VV+GS AV+ ++ VK W E+FG Sbjct: 61 QWQHIQAATKALNVPYQVGGGIRCEQDVSDWLKAGANQVVIGSMAVEKREQVKAWIEQFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ V+ALDV G A GW S L +LV+ Y +G+ LCTDIS+DGT+ Sbjct: 121 AEHFVIALDVNKTATGWAP-ATHGWLTESEFGLLELVDFYANLGVIDFLCTDISKDGTMT 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + +LYE++ + Q+SGG+ +DD+ L+ G+ G+I+G++LL+G F+V+EA+A Sbjct: 180 GPSFALYEDLIKHNSTIKVQASGGVSSLDDIKKLKELGIGGIILGKSLLDGAFSVEEALA 239 >UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alphaproteobacteria RepID=HIS4_MARMM Length = 244 Score = 212 bits (539), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 112/245 (45%), Positives = 160/245 (65%), Gaps = 2/245 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL+DG VVRLH+G + DYG+DP+ + + GA +H+VDL+GA+D A+R Sbjct: 2 ILYPAIDLLDGRVVRLHKGAFDAVTDYGDDPMRVAEQFGEAGAVWVHIVDLSGARDGARR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI++L + VQ GGGVRS ED+ LL AGV RV++GS AV + V GW + +G Sbjct: 62 QGALIRSLCE-TGLRVQTGGGVRSAEDIEDLLAAGVERVIIGSLAVTDTNRVAGWLQNYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + LALDVR G + A+ GW + + +L+ ++ Y GL H L TDI RDG L+ Sbjct: 121 GDRITLALDVR-QIGGQYRPALKGWTDMADTTLDDVISAYEGTGLAHALVTDIGRDGDLS 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N++LY+ + YP + +Q+SGG+ +DD+ A R G G I G+AL EG+FTV EAIA Sbjct: 180 GPNIALYKRLATDYPNIDWQASGGVSSLDDLRAARAAGAAGAITGKALYEGRFTVGEAIA 239 Query: 241 CWQNA 245 C ++A Sbjct: 240 CLRDA 244 >UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=21 Tax=Bacteria RepID=HIS4_XYLF2 Length = 269 Score = 209 bits (532), Expect = 6e-53, Method: Compositional matrix adjust. Identities = 108/239 (45%), Positives = 150/239 (62%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PALD+ +G VVRL QGDY +Q Y + LPR Q +A GA +HLVDL AK Sbjct: 4 IVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYT 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 PL++ + + VQ GGGVRS +DVA +L+AG ARVV+GS AV+ V W + FG Sbjct: 64 LAPLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFG 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +ALD R D G ++ V GW E + +LE L + Y GL+H+LCTDI+RDG L+ Sbjct: 124 PERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALAQQYAAAGLRHLLCTDIARDGMLS 183 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N+ +Y + A P V Q SGG D+ DV A + G G+++G+ALLEG+ +KEA+ Sbjct: 184 GPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKEAV 242 >UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=B4W8G6_9CAUL Length = 243 Score = 202 bits (513), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 112/242 (46%), Positives = 151/242 (62%), Gaps = 3/242 (1%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL G + + Y P RL +AA+GAE +H+VDL GA+ Sbjct: 2 LIYPAIDLKDGVCVRLMHGKFDQVTRYDEQPATRLSAFAAEGAEWIHVVDLDGAEAGEAV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI L ++V +Q GGGVRS DVA LL+ GV+RVVVGS AV + V W + FG Sbjct: 62 QHALIGELTKAIDVKIQSGGGVRSANDVAKLLDTGVSRVVVGSLAVTQPNDVAAWLKGFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGL-KHVLCTDISRDGTL 179 A+ + LA DV+I E G A+ GW ++SGV L ++ Y P GL KH+L TD+ RDG + Sbjct: 122 AEHITLAFDVKI-EDGVPVPALKGWTQSSGVDLWTALDRY-PKGLFKHLLVTDVGRDGAM 179 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N+ L E+ R P + Q+SGG+ +DD+AA++ G G IVGRAL E +FT+ +AI Sbjct: 180 TGPNLELLAEIRRRRPDLVLQASGGVSSLDDIAAVKSLGCNGAIVGRALYENRFTLPDAI 239 Query: 240 AC 241 A Sbjct: 240 AT 241 >UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=C7PAV4_CHIPD Length = 389 Score = 187 bits (476), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 92/236 (38%), Positives = 147/236 (62%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+IDG VRL QGDY +++ Y PL + + + G LHLVDL GAK A Sbjct: 148 VIPAIDIIDGKCVRLTQGDYAQKKVYNEHPLEVAKAFESIGIRRLHLVDLDGAKKGAVVN 207 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + N+ + GGG+++E+D+ + E G A +GS AVK + GW +++GA Sbjct: 208 WKVLEAIAGKTNLVIDFGGGIKTEDDLRIVYENGAALATIGSIAVKDPALFSGWVKKYGA 267 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + L DV+ +++AV GW E + +S+ +E + G++H+ CTDI++DG L G Sbjct: 268 DKIFLGADVK-----EEKIAVGGWLETTELSVFDFLEENVKQGVQHIFCTDIAKDGLLQG 322 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 +V+LYE++ R+PQ+ F +SGG+ + DV AL G GVIVG+A+ E + ++KE Sbjct: 323 PSVALYEKILQRFPQIDFVASGGVSTMADVHALAEAGCSGVIVGKAIYEERISMKE 378 >UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZT22_9SPHI Length = 239 Score = 186 bits (471), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 87/228 (38%), Positives = 142/228 (62%), Gaps = 5/228 (2%) Query: 10 DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLV 69 +G VRL QGDY ++R Y DP+ Q YA +G + LH+VDL GAK A + + L++ + Sbjct: 12 NGQCVRLTQGDYSQKRVYDKDPIEMAQKYADEGFQRLHVVDLDGAKSGAPKHLALVEQMA 71 Query: 70 AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALD 129 A N+ + GGG+++ E V A+L+AG A +GS AVK ++ KGW + FG+D ++LA D Sbjct: 72 AKTNLTIDYGGGIKTTEQVQAVLDAGAAMANIGSLAVKQPEVFKGWLQTFGSDKILLASD 131 Query: 130 VRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEE 189 V+ +++A++ WQ+ S VS+ + ++P GL CTD+S+DG L G + LY + Sbjct: 132 VK-----GEKIAINAWQDESEVSIYDFIADFIPSGLTQFFCTDVSKDGLLQGVALELYCK 186 Query: 190 VCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 + ++P + +SGG+ + D+ L G+ GVIVG+A+ E + ++E Sbjct: 187 LKQKFPTMTIIASGGVASMQDIEDLNKEGIDGVIVGKAIYENRIALEE 234 >UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=35 Tax=cellular organisms RepID=HIS4_GRAFK Length = 241 Score = 183 bits (465), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 84/236 (35%), Positives = 145/236 (61%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D+I+G VRL +GDY ++ Y DPL + + A G E LHLVDL GAK Sbjct: 3 IIPAIDIIEGKCVRLSKGDYATKKIYNEDPLEVAKSFEAHGIEYLHLVDLDGAKSSHIVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++T+ ++ + GGG+++++D+ E+G +++ GS AVK+ D+ + W ++FG Sbjct: 63 HKILETIANKTSLKIDFGGGLKTDKDLQIAFESGASQITGGSIAVKNSDVFQNWIQKFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++L D + ++++AVSGW E+S + ++ Y G+K+V+CTDIS+DG L G Sbjct: 123 KKIILGADAK-----DRKIAVSGWLEDSNEEIIPFIQNYEEKGVKYVICTDISKDGMLEG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 + LY+E+ + + +SGGI + D++ L G GVI+G+A+ E + ++K+ Sbjct: 178 PSFELYKEILSETKNINLIASGGISEFDELPKLAELGCEGVIIGKAIYENRISLKQ 233 >UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Legionella pneumophila RepID=HIS4_LEGPL Length = 239 Score = 170 bits (430), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 89/240 (37%), Positives = 142/240 (59%), Gaps = 2/240 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL G VRL QG + + + P+ R +A GA+ LH+VDL GA+ + Sbjct: 2 LVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ LI ++ + +Q GGG+RS E AG++++V+GS A+ + D+ E+ Sbjct: 62 QLELICSM-QKTGIAIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIK 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VLALDVR+D + +A++GWQ NS SL ++V Y G+KH+LCTDI+ DG + Sbjct: 121 PENIVLALDVRVDTKV-PLLAINGWQNNSTSSLWEVVSYYENHGIKHILCTDIACDGMMN 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N LY++ +PQ+A+Q+SGGI + D+ L G+ VI+G L + +E + Sbjct: 180 GPNFDLYQQAVEYFPQIAWQASGGIRHMQDITTLGSLGISAVILGLMLYQDNVNFEELLC 239 >UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=24 Tax=Bacteroidetes RepID=HIS4_PARD8 Length = 239 Score = 169 bits (429), Expect = 6e-41, Method: Compositional matrix adjust. Identities = 83/236 (35%), Positives = 136/236 (57%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+IDG VRL QGDY ++ Y DPL + + G LH+VDL GA++ Sbjct: 4 LIPAIDIIDGKCVRLTQGDYATKKVYNEDPLEVAKMFEGNGIRRLHVVDLDGAREGRIIN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + ++ + GGG++ E+D+ E+G V GS AVK+ +M W +FG+ Sbjct: 64 YRILERIATRTSLIIDFGGGLKQEDDLEIAFESGAQMVTGGSIAVKNPEMFTSWISKFGS 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++L D + K++A+SGW+E + L ++ Y G+ V+CTDI+RDG L G Sbjct: 124 EKIILGADAK-----EKKIAISGWEETTSQELVPFIKGYYDKGITKVICTDIARDGMLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 + LY+E+ P + +SGG+ I+D+ L G+ VI G+A+ EGK +K+ Sbjct: 179 PAIDLYKEIRDEIPFLYIIASGGVSSIEDIEKLSEAGIPAVIFGKAIYEGKIQLKD 234 >UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RFK6_LEGLO Length = 246 Score = 165 bits (417), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 87/240 (36%), Positives = 135/240 (56%), Gaps = 2/240 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL G VRL QG + + + P+ R +A GA+ LH+VDL GAK + Sbjct: 2 ILIPAIDLQAGRCVRLRQGQFDQVTQFDMSPIDRASYFAKLGAKRLHIVDLDGAKIGTMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+PLI T+ V VQ GGG+RS E AG++ +V+GS A+ + Sbjct: 62 QLPLICTM-QHTGVTVQAGGGIRSLEQAKTCYSAGISLLVIGSIAITDPGLTTKIINEIS 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++LALD+R+ E A GWQ S ++L ++V Y +G+ +LCTDI+ DG + Sbjct: 121 PKNIILALDIRM-ENKIPLPATHGWQTTSTMNLWEVVSFYQQLGITQILCTDIASDGMMQ 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N LY+E R+P +A+Q+SGGI DD+ L+ G++ I+G + + F +K ++ Sbjct: 180 GPNFDLYQEAVERFPNIAWQASGGIRHQDDINKLQKLGIKAAILGLTMYQDVFNLKSILS 239 >UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Salinibacter ruber DSM 13855 RepID=HIS4_SALRD Length = 258 Score = 162 bits (410), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 89/247 (36%), Positives = 144/247 (58%), Gaps = 9/247 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ DG VRLHQGDY + Y DP+ + + Q A+ LH+VDL A+ + Sbjct: 3 LVIPAIDIRDGRCVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEH 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + +++P+Q+GGG+RS + + A L+ GV RV++G+ AV++ D V+ E+F Sbjct: 63 NRDVIGKMCDALDIPIQLGGGIRSMDQIEAALDRGVYRVILGTAAVRNPDFVERAVEQFS 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A +V+++D R + +V V GW E SG+ + G++ ++ TDISRDGT+ Sbjct: 123 ARRVVVSIDAR-----DGEVRVQGWTEGSGLDAVAFAKDMEQRGVRRLVYTDISRDGTMD 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDID---DVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N+ Y + + +SGG+G+ D D+ L+ GV VIVG AL E +F ++ Sbjct: 178 GPNIQAYRTLGRQLAHAKVTASGGVGEHDDLLDIQTLQPYGVDSVIVGTALYENRFPCQQ 237 Query: 238 AIACWQN 244 A WQ+ Sbjct: 238 FWA-WQD 243 >UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N0X3_9GAMM Length = 240 Score = 161 bits (408), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 89/242 (36%), Positives = 141/242 (58%), Gaps = 4/242 (1%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ G VRL QG + + + P+ R +A GA+ LH+VDL GA+ + + Sbjct: 2 ILIPAIDIQAGRCVRLKQGQFEQITIFDTPPVERAAYFAKIGAQRLHVVDLDGAQIGSMQ 61 Query: 61 QIPLIKTLV-AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 Q+PLI ++ G+NV Q GGG+RS E AG+A +V+GS A+ ++++ + Sbjct: 62 QLPLICSMQNTGINV--QAGGGIRSLEQAKLCFSAGIANLVLGSIAISNRELATQIIQEI 119 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 ++LALD+R+ G A GWQ S +L +V Y +G++ +LCTDI+ DG + Sbjct: 120 SPKNIILALDIRLIN-GIPIPATHGWQTMSNRNLWDVVSYYQQLGIQQILCTDIACDGMM 178 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N SLY+E R+P + +Q+SGGI + +D+ AL GV I+G +L +G + E Sbjct: 179 QGPNFSLYQEAVKRFPMIDWQASGGIRNQEDIEALDKLGVAAAILGLSLYQGTLHLAEYK 238 Query: 240 AC 241 C Sbjct: 239 PC 240 >UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillus RepID=HIS4_LACPL Length = 241 Score = 161 bits (407), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 87/237 (36%), Positives = 133/237 (56%), Gaps = 5/237 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI PA+DL G VRL+QGD+ + DP+ + Q A G + LH+VDL GAK Sbjct: 3 MIFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSGRPE 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I + +++GGG+R+ E LE G+ R+++GS A+ +VK FG Sbjct: 63 NFATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLSEFG 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+ LD N VA+ GW E S + L++T G KH + TD++RDGT+ Sbjct: 123 GERIVIGLD-----GTNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTDVARDGTMQ 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N++LY+E+ A+ P +SGG+ ++ DV L+ +G + VI+G+AL EG T+ E Sbjct: 178 GPNLALYQELQAQVPTANLIASGGVRNLTDVQVLQASGFKDVIIGKALAEGGVTLAE 234 >UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Cyanobacteria RepID=HIS4_PROMS Length = 255 Score = 160 bits (405), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 81/240 (33%), Positives = 144/240 (60%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL++G VRL +GD+ K++D+ +P + + + +GA+ +H+VDL AK + Sbjct: 3 LIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSPTN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + VN+P+Q+GGG+RS+E + L GV +V++G++A++++++VK +F Sbjct: 63 DKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKFPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D + + +V+ GW E S + LV+ + + + TDI+ DGTL G Sbjct: 123 -RIIVGIDAK-----DGKVSTRGWLEQSNIFATDLVKEFSSFKIASFIVTDINTDGTLEG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKEA 238 +N + + + +SGG+G I D+ +L +G+ GVIVG+AL E KFT+ EA Sbjct: 177 TNEEFIKSIL-EITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFTINEA 235 >UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=2 Tax=Pedobacter RepID=C6Y3G6_PEDHD Length = 249 Score = 158 bits (400), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 87/247 (35%), Positives = 144/247 (58%), Gaps = 12/247 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++DG VVRL +GDY ++ Y ++ Y + G E +H++DL GAK Q Sbjct: 3 IIPAIDILDGKVVRLTEGDYNQKTVYDVSIAEMIETYRSNGTEFIHIIDLNGAKGDFSNQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG- 120 L + ++ ++ VQ GGG+R+ + V LL+AG+ RV+VG+ A+ + D ++ + G Sbjct: 63 KALFE-VIKKTDMRVQYGGGIRTIKQVTDLLDAGIHRVIVGTQAITNPDFLQELSKEVGK 121 Query: 121 ----ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 A+ +V+A+DV +DE + SGW E+S + L V+ L +G LCTDI++D Sbjct: 122 KYDYANRIVIAIDV-LDEV----IKYSGWMESSPIKLMDYVDKCLQLGFFRFLCTDINKD 176 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G L G+ V LY+++ P + +SGG+ + D+ L +R V+VG+A+ E + T+ Sbjct: 177 GKLGGAAVELYKKLLEHSPFIKLIASGGVSSMKDIEELDKYDIRSVVVGKAIYENRITI- 235 Query: 237 EAIACWQ 243 + I W Sbjct: 236 DQIKEWN 242 >UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Bacillales RepID=HIS4_BREBN Length = 249 Score = 158 bits (399), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 96/244 (39%), Positives = 139/244 (56%), Gaps = 14/244 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+D+ G VRL QGDYG++ Y + PL + + QGA +HLVDL GAK+ Sbjct: 4 IVYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEGKPA 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + + VPVQVGGG+R+EE +A LEAGVARV+VG+ A++ + K + G Sbjct: 64 NAAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQNDG 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + LD R N VA GW + V +L + + G + + TDI+RDGT+ Sbjct: 124 -DKIAIGLDCR-----NGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTDIARDGTMT 177 Query: 181 GSNVSLYEEVCARYPQV--AFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTV 235 G NV EE+ A + +SGG+ +DD+ L GV G IVG+AL FT+ Sbjct: 178 GPNV---EEIAALAMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYTDAFTL 234 Query: 236 KEAI 239 +EA+ Sbjct: 235 EEAL 238 >UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Firmicutes RepID=HIS4_CLOD6 Length = 240 Score = 155 bits (392), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 83/238 (34%), Positives = 142/238 (59%), Gaps = 7/238 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ D VRL QG++ K Y ++PL + +GAE +H+VDL GA+ Sbjct: 2 IIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ + +++P+QVGGGVR +E V +L+ AGV RV++GS A+++ ++V+ + Sbjct: 62 NTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+++D + + +VAV GW+ S V L + +G++ ++ TDIS+DG L Sbjct: 121 KEKIVVSIDAK-----DGKVAVRGWEVVSNVDSLTLCKQLEKIGVQTIVYTDISKDGMLQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N +YE + A+ + +SGG+ I+DV L+ + G I+G+AL + K KEA Sbjct: 176 GPNFDIYERI-AKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEA 232 >UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CALS8 Length = 237 Score = 155 bits (391), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 87/243 (35%), Positives = 140/243 (57%), Gaps = 14/243 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+IDG VRL QGDY + ++Y DP+ + + + +GA LH+VDL GAK + Sbjct: 2 IVIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + ++ V+ GGG+R ++ + L AG+ +++GS K+ + V+ +RFG Sbjct: 62 NFEVIKRIKESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +LD E+G V +SGWQE + +S+E+ + +G + ++ TDI DG L Sbjct: 122 NERFIASLDF---EEG--YVKLSGWQEATRISVEEGILHIKKLGFQKLIYTDIKTDGMLK 176 Query: 181 GSNVSLYEEVCARYPQVAFQ----SSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G N A+Y + F SSGGI ++DV L+ GV GVI+G+AL G + Sbjct: 177 GHNFE-----AAKYIRSLFDGFLISSGGISSMNDVLKLKDIGVDGVIIGKALYTGHVKLN 231 Query: 237 EAI 239 E I Sbjct: 232 EII 234 >UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Firmicutes RepID=HIS4_CLOBA Length = 237 Score = 155 bits (391), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 83/239 (34%), Positives = 140/239 (58%), Gaps = 7/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+D+IDG VRL+QGDY K+ ND +++ GAE +HLVDL GAK Sbjct: 2 IILPAIDIIDGQAVRLYQGDYNKKEVVANDIFNIAKEFECLGAEYIHLVDLDGAKSGYCV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I L V+VP++VGGG+R+ E + L+E G++RV++G+ A++ + ++K E +G Sbjct: 62 NEKIILKLAQTVDVPIEVGGGIRNFETIEKLIENGISRVILGTIAMEDEGLLKKAIECYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + N V GW S ++ + +G+K ++ TDIS+DGTL Sbjct: 122 -EKISVGIDCK-----NGYVYGRGWLAESKLNYLDFAKNMESLGVKSIIVTDISKDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N + ++ + + +SGGI DI+++ L+ + G I G+A+ G ++KEAI Sbjct: 176 GPNFDMLMKL-KKLVNIDITASGGIRDIENIKELKNIDIYGAITGKAIYSGNLSLKEAI 233 >UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=17 Tax=Epsilonproteobacteria RepID=HIS4_CAMHC Length = 236 Score = 154 bits (390), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 85/239 (35%), Positives = 139/239 (58%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL +G VRL +G+ + Y + P + +A GA+ LH+VDL GA + Sbjct: 3 ILPAIDLKNGFAVRLKKGEMNSAKIYSDKPWELAEKFADLGAKWLHIVDLDGAFAGEAKN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ +V N+ ++VGGG+R EE + +GV+R ++GS A+K+ + VK +++ Sbjct: 63 AKTIEKIVKSTNLKIEVGGGIRDEERIKFYKNSGVSRFILGSAALKNPEFVKQMAKKY-- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + N VA GW E S + +L + Y G++ ++CTDIS+DG L+G Sbjct: 121 -KIAVGIDAK-----NGFVATEGWAEVSNIKACELAKIYADAGVEAIICTDISKDGMLSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAI 239 NV EE+ A+ + +SGG+ D+ D+ AL+ +G + GVIVG+A EG +KEA Sbjct: 175 VNVKFSEEI-AKSSGIKTIASGGVKDLSDIKALKQSGKIYGVIVGKAYYEGSIDLKEAF 232 >UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Halothermothrix orenii H 168 RepID=HIS4_HALOH Length = 237 Score = 154 bits (390), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 83/235 (35%), Positives = 139/235 (59%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG+ VRL +GD+ K+R Y P+ + GA LH+VDL GAK Sbjct: 3 VIPAVDIKDGSCVRLKKGDFNKRRVYSTSPVDVALYWEKHGASRLHIVDLDGAKSGWPTH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + I+ + VN+P+QVGGG+RS + + L++GV R+++G+ A+K+ ++VK + FG+ Sbjct: 63 LKTIREIALRVNIPLQVGGGIRSLKVIKKYLDSGVDRIILGTVALKNPELVKRALDNFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V+ +D R +VA GW + S V++E ++ VG+K + TDI+RDG L G Sbjct: 123 NRIVVGVDAR-----GGKVATEGWLKTSQVTVEDIISEMEEVGVKTFIYTDINRDGMLKG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 ++ + V + + +SGGI D+ L+ G++ IVG+AL EG ++ Sbjct: 178 PDIEGIKRVL-KSTKARIIASGGISSRQDLINLKAIGIKAAIVGKALYEGNLPLE 231 >UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MJ01_RHOM4 Length = 266 Score = 154 bits (388), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 90/247 (36%), Positives = 139/247 (56%), Gaps = 10/247 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ G VRL+QG Y ++ Y +DP+ + Q A VLH+VDL A+ Sbjct: 3 LVIPAIDIRGGRCVRLYQGSYERETVYFDDPVKMACLWRVQNARVLHVVDLDAARGQGHN 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I + V++P+QVGGGVR+ ED+ ALL+ GV RVV+G+ AV+ ++V R+G Sbjct: 63 R-EVIGAICRTVDIPIQVGGGVRTLEDIEALLQVGVYRVVLGTAAVREPELVSEAIARYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D R + +V V GW E +GV +L G++ + TDISRDGTL Sbjct: 122 CSRVVVGIDAR-----DGEVRVQGWTEGTGVDAVELALDMERRGVRRFVYTDISRDGTLE 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIG---DIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G NV +Y + + +SGG+ D+ + L V VI+GRAL E +F ++ Sbjct: 177 GPNVEMYRTLGLHLKKARITASGGVSGYRDLMRLQELEPYRVDSVIIGRALYENRFPCQQ 236 Query: 238 AIACWQN 244 CW + Sbjct: 237 -FWCWHD 242 >UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Leptospira RepID=HIS4_LEPBL Length = 241 Score = 154 bits (388), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 88/247 (35%), Positives = 146/247 (59%), Gaps = 14/247 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL D VRL +G+Y +++ Y ++P + +A GA +LHLVDL GA++ Sbjct: 2 IIIPAIDLFDNCAVRLFKGNYKEKKIYSSEPWKLAEGFAKNGATLLHLVDLNGARNQLGI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I + ++ VQ+GGG+R +E +A + G+ R ++G+ AV D++K + + Sbjct: 62 NEDSILKIRKTTSLKVQLGGGIRDKEKLAYYDKIGIDRFILGTAAVTDPDLLKFALDNYE 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+A+D ID V ++GW+++SGV L++ G++H++ TDI++DGTLA Sbjct: 122 KERVVVAVDA-ID----GIVKIAGWEKDSGVRYRDLMDRLAKAGIEHIVFTDIAQDGTLA 176 Query: 181 GSNVSLYEEVCARYPQVAFQ--SSGGIGDIDDVAALRGTGVR----GVIVGRALLEGKFT 234 G N+ Y+E+ YP FQ +SGGI + D+ L + GVI G+AL EGK Sbjct: 177 GPNLKAYQEILNSYP---FQVIASGGISSLKDLMDLSSLKTKIPLYGVITGKALYEGKLD 233 Query: 235 VKEAIAC 241 + +AI+ Sbjct: 234 LAKAISS 240 >UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Aquificales RepID=HIS4_SULSY Length = 239 Score = 153 bits (387), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 88/242 (36%), Positives = 148/242 (61%), Gaps = 14/242 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ G VVRL++G++ K + Y +P+ + + GAE +H+VDL GA + + Sbjct: 6 FIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEGLPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I +++++V VN+P++ GGG+RS E V A+L+ GV RVV+GS A ++ + E F Sbjct: 66 NIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIVESF- 124 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +++ +D + + +VA+ GW E + VS + + Y + + L TD+SRDG++ Sbjct: 125 PNKVIVGIDAK-----DGKVAIKGWTEKTEVSPLEFAKKYDDLDIFGFLFTDVSRDGSMI 179 Query: 181 GSNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTV 235 G+NV E+ ++P +A SGG+G ++DV L R G+ GV+VG+A+ EGK + Sbjct: 180 GANVEATVELAKNLKHPVIA---SGGVGSLEDVIKLYEKREFGIFGVVVGKAIYEGKIDL 236 Query: 236 KE 237 KE Sbjct: 237 KE 238 >UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_LACLS Length = 246 Score = 153 bits (387), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 84/237 (35%), Positives = 138/237 (58%), Gaps = 7/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL +G VRL++GDY K+ Y +PL Q + GA+ LHLVDL GAK R Sbjct: 3 IIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQTRN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEA-GVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ + N+ +++GGG+R+ + V+ LE GV RV++G+ A + D +K ++G Sbjct: 63 LEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYG 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D+R V+ SGW E + + ++ +G+K V+ TDIS+DGTL Sbjct: 123 LSRIVVGVDIR-----EGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISKDGTLT 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N LY+E+ ++ + SGG+ D D+ + G+IVG+A EGK +++ Sbjct: 178 GPNFELYDEI-SKETSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEK 233 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 152 bits (385), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 84/237 (35%), Positives = 135/237 (56%), Gaps = 5/237 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI PA+DL DG VRL++GD+ ++ DP+ + + Y A LHLVDL GAK Sbjct: 1 MIFPAIDLQDGRSVRLYKGDFAQETVINPDPVDQAKQYEAAKVGALHLVDLDGAKAGKPV 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++K + A +++GGG+R +E V L GV RV++GS A+K+ + K +G Sbjct: 61 NVDIVKAVRAAFTGILEIGGGIRDKEAVDLYLSLGVDRVILGSVALKNPKLTKQVIAEYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ +V+ +D + N +VA GW + S V + L+ + G K+ + TD+ RDGT+ Sbjct: 121 AEHIVIGVDGK-----NGKVAAEGWLDQSDVPMTDLIGAMIEGGAKYFIVTDVDRDGTMQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G+N L + +P +SGG+ +++D+ +L GV IVG+AL EG T++E Sbjct: 176 GANEELLGNLQKEFPTARIVASGGVRNLEDIKSLEQKGVMDSIVGKALYEGTITLEE 232 >UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=15 Tax=root RepID=HIS4_DEHSC Length = 244 Score = 152 bits (384), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 88/238 (36%), Positives = 137/238 (57%), Gaps = 7/238 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++ G VRL QGDY ++ Y +DP+ + + GA LH+VDL GA D Sbjct: 10 IIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQSVN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LIK + +PV+VGGG+RS E V LL AGV RV++G+ AV++ ++VK R+ A Sbjct: 70 FELIKEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICARY-A 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D++ +++D R N +VA GW N+ + +L + +G++ + TDISRDGTL+ Sbjct: 129 DSVAVSIDAR-----NGKVATRGWVTNTEIDALELARSMKKLGIRRFIYTDISRDGTLSE 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 N + ++ + V +SGG+ + + L+ G G IVG+A+ G +K A Sbjct: 184 PNFAAIRDLISAI-NVPVIASGGVSSLSHLRLLKDIGAEGAIVGKAIYTGDLNLKRAF 240 >UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G189_ABIDE Length = 238 Score = 152 bits (383), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 74/239 (30%), Positives = 143/239 (59%), Gaps = 7/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ +G VVRL +GDY K Y + + + + A G E LHLVDL GAK+ Sbjct: 5 IIFPAIDIYEGKVVRLLKGDYNKMTIYSENVVDKACEIEAAGGEWLHLVDLEGAKEGNTP 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ + + V++GGG+R+E + + AGV R+++G+ A ++ + +++ Sbjct: 65 NFTYVEEICKKTGLKVEIGGGIRTEATIEKYINAGVNRIILGTKAATDKEFLNKMTDKY- 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +DV+ +++VA+ GW E + ++ V +G+K+++ TDI++DG ++ Sbjct: 124 REKIAVGIDVK-----DEKVAIKGWLEVTDKTIFDFVTELKEIGIKNIIVTDIAKDGAMS 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G NVS YE++ +++ + +SGG+ +DD+ L+ TG+ G I+G+A+ G ++EA+ Sbjct: 179 GINVSFYEKL-SKFTDMDITASGGVTTLDDLIRLKNTGIYGAILGKAMYTGNVDLREAL 236 >UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBX0_9FIRM Length = 234 Score = 151 bits (382), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 85/241 (35%), Positives = 136/241 (56%), Gaps = 8/241 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ D VRL QGDY KQ Y ++P +D+ +G + LH+VDL A Sbjct: 2 IIFPAIDIRDNKCVRLSQGDYDKQTVYFDNPFTVAEDFEKRGVKYLHIVDLDAALIGKLT 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK ++ N+ ++VGGG+R EE + ++ GV RV +G+ AVK +K E++ Sbjct: 62 NFDIIKKIITDTNMLIEVGGGIRGEEQIKKYVDIGVDRVSIGTKAVKDFAFLKEMSEKYP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + L+LDV+ ++ V + GW ENSG+ + ++ + L ++ TDI +DG L+ Sbjct: 122 Y-KISLSLDVK-----DEYVYIKGWSENSGILIWDYLDKIKDLPLTGIVVTDIKKDGMLS 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + LY ++ + + SGG+ +DD+ L+ GVIVG+AL E KF+V E I Sbjct: 176 GPSFELYRKL-KKATKHNIVVSGGVSSLDDINKLKEDDTYGVIVGKALYENKFSV-EDII 233 Query: 241 C 241 C Sbjct: 234 C 234 >UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Leptospira biflexa serovar Patoc RepID=HIS4_LEPBA Length = 247 Score = 151 bits (381), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 82/242 (33%), Positives = 139/242 (57%), Gaps = 8/242 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+DL+D VRL QGDY K+ Y + P +Q + QGA ++H+VDL AK Sbjct: 2 LVLPAIDLLDNEAVRLLQGDYSKKTVYSSSPEKMIQVFEEQGATLIHIVDLNAAKTGKSE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 IK + V +++GGG+R+ +++ GV+R+++G+ AV+ ++V+ FG Sbjct: 62 NEKTIKKIKEKCTVDLELGGGIRTIDNMKFYDGLGVSRLILGTVAVEEPNVVEKAVSLFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V+ +D + N V GW+ NSG+ + + T +G++HV+ TDI+RDG + Sbjct: 122 QDRIVIGVDAK-----NGYVRTKGWESNSGILYKDFLTTMYGMGIRHVIFTDIARDGMME 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL--RGTG-VRGVIVGRALLEGKFTVKE 237 G N Y E+ +P + +SGG+ +D+ L + G + G I G+A+ EGK +KE Sbjct: 177 GPNTLAYAELLETFPDLQLVASGGVSSKEDLVELYDKTNGKLFGAITGKAIYEGKLDLKE 236 Query: 238 AI 239 +I Sbjct: 237 SI 238 >UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW7_9FIRM Length = 243 Score = 150 bits (380), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 91/242 (37%), Positives = 143/242 (59%), Gaps = 10/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ G VRL +GD+ K+ + + P + + QGA+ LHLVDL GA + Sbjct: 2 IIFPAIDIRGGKCVRLLKGDFAKETVFSDKPEEMAKKWQTQGAQFLHLVDLDGALAGRPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +K ++A V++PV++GGG+R+ E + +L GV RV++GS AV+ ++VK ++G Sbjct: 62 NLATVKAILAAVDIPVELGGGIRTLESIDEVLALGVRRVILGSVAVRDPELVKTACAKYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V+ +D + + VAV GW + V L + G+K ++ TDISRDGTLA Sbjct: 122 -DRIVVGIDAK-----DGIVAVDGWGVSGDVEATALAKEMKKAGVKTIIYTDISRDGTLA 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR---GTGVRGVIVGRALLEGKFTVKE 237 G NV ++ AR VA +SGG+ I D+ AL+ G+ GVIVG+++ G + E Sbjct: 176 GVNVEATAKL-ARESGVAVVASGGVKSIADIEALKPYEKAGIEGVIVGKSIYMGTLDLAE 234 Query: 238 AI 239 AI Sbjct: 235 AI 236 >UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=6 Tax=Euryarchaeota RepID=D2RTG3_9EURY Length = 244 Score = 148 bits (374), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 92/237 (38%), Positives = 139/237 (58%), Gaps = 8/237 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG VV+L QG+ G ++ YG DP+ + + +GAE LHLVDL GA + + Sbjct: 9 VIPAVDMQDGEVVQLVQGERGTEKTYG-DPVDAARRWLDEGAEALHLVDLDGAFEGQRAN 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V+VP Q+GGG+R+ +D LLE GV RV++G+ AV++ D+V ER Sbjct: 68 GDAIDEVLETVDVPTQLGGGIRTADDAVDLLERGVDRVILGTAAVENPDIVAEISERH-P 126 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D++V++LD + + +V V GW E +G+S E Y +G +L T++ +G L G Sbjct: 127 DSVVVSLDAK-----DGEVVVEGWTEGAGISPVDAAERYAELGAAAILFTNVDVEGKLEG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 E+ V +SGG+ ++DV AL G V+VG AL EGKFT+ EA Sbjct: 182 VAAEPVRELV-EATDVPVIASGGVATLEDVRALEDAGAAAVVVGSALYEGKFTLAEA 237 >UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=91 Tax=Bacteria RepID=HIS4_SYNJB Length = 261 Score = 148 bits (373), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 99/249 (39%), Positives = 144/249 (57%), Gaps = 13/249 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL+ G VRL+QGDY + +DP+ + + +AAQGA LH+VDL GAK Sbjct: 10 VIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P+I+ +V + +PVQVGGG+RS E LL+ GV RV+VG+ AV+ D ++ + F Sbjct: 70 LPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPG 129 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 V +D R QG QVA GW + + +LV+ G ++ TDISRDGTLAG Sbjct: 130 RVWV-GIDAR---QG--QVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRDGTLAG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGD-IDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 N+ ++ A QV +SGGIG D +A L + G I+G+AL G +++EA+ Sbjct: 184 PNLEQLRQILA-VSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEALR 242 Query: 241 C-----WQN 244 WQ+ Sbjct: 243 AVGPGRWQD 251 >UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFDF6 Length = 236 Score = 148 bits (373), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 83/239 (34%), Positives = 138/239 (57%), Gaps = 7/239 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G +VRL +G Y + + Y DP L+ + +GA LH+VDL GAK Sbjct: 3 IFPAIDIKNGQIVRLTEGKYDQVKVYSKDPEEVLEHFTKEGATALHIVDLDGAKSGTIEN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IKT++ + Q+GGG+R E + L GV RV++G+ AV++ V+ +++ Sbjct: 63 QNTIKTILKNRHFVTQLGGGIRDESTINHYLNMGVDRVILGTVAVENPKFVEEMVKKYDQ 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + V +DE+ + QV +GW NS V + + +G+ ++ TDIS+DG +AG Sbjct: 123 Q-----IAVGVDEK-DGQVRANGWLVNSKVDAIEFCKMLTAMGVATIIYTDISKDGMMAG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 +++ Y ++C + +V +SGG+ I ++ L+ GV GVIVG+A+ EGK ++EA A Sbjct: 177 CDMASYRQLC-KDRKVNIIASGGVTSIAEIKELKRIGVAGVIVGKAIYEGKIALREATA 234 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 147 bits (372), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 80/243 (32%), Positives = 141/243 (58%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ DG VRL +G + + Y P + + GA+ +H VDL GA Sbjct: 3 LYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + + VNVPVQ+GGG+R+ E++ +L+ GV RV++G+ AV++ D +K +RFGA Sbjct: 63 AETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V+ +D + + VA+ GW++ S + L +G++ ++ TDIS+DG LAG Sbjct: 123 EHIVVGVDAK-----DGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDISKDGMLAG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV ++ + + +SGG+ +DD+ + G+ G I+G+A+ E + +KEA+ Sbjct: 178 PNVE-QTKILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNL 236 Query: 242 WQN 244 +++ Sbjct: 237 FES 239 >UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF74_THET1 Length = 243 Score = 147 bits (371), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 84/243 (34%), Positives = 149/243 (61%), Gaps = 8/243 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+++G +VRL QGDY +++ Y DP+ + + A GA+ LH+VDL GA+ Sbjct: 2 IVIPAIDILEGQLVRLTQGDYSRKKVYSYDPVVVARKWKAIGAQWLHVVDLDGARQGHPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +IK+++ VQVGGG+R+ ED+ +++E G +R+V+G++AVK + ++ ++ Sbjct: 62 NVDVIKSVIMEFGPQVQVGGGLRTLEDIQSIVELGASRIVLGTSAVKDPEFLREVCAKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V ALD R N VA+ GW ++SG+ + ++ + G+ ++L T I DGT+ Sbjct: 121 PDMVVAALDTR-----NGVVAIDGWTKSSGLDVLEVAKLVEDAGVGYILFTAIETDGTMT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G +++ + + + + V +SGGI + +D+ L GV VIVG+AL EG+ +E I Sbjct: 176 GPDIAAVQRLMS-HVSVPVIASGGISEPEDLEELSKAGVYAVIVGKALYEGRLP-EEVIT 233 Query: 241 CWQ 243 + Sbjct: 234 TYS 236 >UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB3_9BACT Length = 239 Score = 147 bits (370), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 87/238 (36%), Positives = 140/238 (58%), Gaps = 10/238 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL VVRL GD+ K ++YG+DP+ +A GA +HL+DL GA+ + Sbjct: 6 IYPAIDLYSRKVVRLTGGDFEKIKEYGDDPVETALSFAEAGARWIHLIDLEGAEKGSPVH 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + A +PVQ GGG+R+EEDVA L +G RV +GS K + ++RFG Sbjct: 66 LKELEKVAASTGLPVQYGGGLRTEEDVALALSSGAKRVYLGSLLFKGSP--RTLWKRFG- 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++V ++DV+ N VA+SGW E + + E+ + L +G L T +SRDGT +G Sbjct: 123 NSIVPSVDVK-----NGTVALSGWTEVTQLPPEEAITELLRIGYSTFLVTSVSRDGTASG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 ++ LYE + ++ ++GGI D D+A L GV G ++G+++ EG ++EA+ Sbjct: 178 PDLKLYERLKKTDGRIL--AAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAV 233 >UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DY29_METI4 Length = 248 Score = 146 bits (368), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 90/239 (37%), Positives = 135/239 (56%), Gaps = 11/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + A+DL G VVRL QG + YG+DP+ + +QGA+ LH+VDL GA R Sbjct: 11 MYAAIDLFKGQVVRLRQGKLEEMTVYGSDPVKTALFWQSQGADGLHIVDLEGAFSGTPRH 70 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L++ + V +P+Q GGG+R+ E V LE G RVV+GS V ++ E+ G Sbjct: 71 LDLLEKIAYAVTIPIQFGGGLRTVEQVLKALEGGAQRVVIGSKLVTDPGFLQELSEKIGP 130 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V ALD + N ++ + GW+++SG SLE ++ G +L T+I DGTL G Sbjct: 131 EKIVAALDTQ-----NGEIQIEGWKKSSGYSLENFIKWVEQKGAGFLLYTNIQTDGTLKG 185 Query: 182 SNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKE 237 ++V ++V +R P A SGGIG DV L+ G+ G I+GR+L EGK ++ E Sbjct: 186 ADVRGTQKVVEMSRLPVFA---SGGIGCTKDVEELLKLKGLYGAILGRSLYEGKISLSE 241 >UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=HIS4_THERP Length = 244 Score = 145 bits (367), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 95/234 (40%), Positives = 142/234 (60%), Gaps = 9/234 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL +G VRL +GD+ + Y +DP+ Q +A+ GA LH+VDL GA+ Sbjct: 2 IVIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPV 61 Query: 61 QIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 Q LI+ ++ V +V VQVGGGVR+ + V LL G ARVV+G+ A++ DM++ RF Sbjct: 62 QHELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALARF 121 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G + +V+A+D R + VA GW+ + +E++V + +G++ VL TD++RDGTL Sbjct: 122 GVERVVVAVDSR-----DGWVATHGWETVQAIRVEEVVHRVVLLGVRRVLATDVTRDGTL 176 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGK 232 N+ L + A V +SGG+G D+ AL R GV IVGRAL EG+ Sbjct: 177 TRPNLELMGRLAA--LGVTVIASGGVGSRSDLEALARVPGVEAAIVGRALYEGR 228 >UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZQ4_9SPHI Length = 250 Score = 145 bits (367), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 89/250 (35%), Positives = 142/250 (56%), Gaps = 17/250 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++D VVRL +G+Y Y ++ Y A G E++H++DL GAK Q Sbjct: 3 IIPAIDVLDKKVVRLREGNYDDVTTYDISLEEQIDRYHANGTELVHIIDLNGAKGDFSNQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK-------G 114 L ++ + +Q GGGVRS E V L++AGV RV+VG+ A+ + + ++ G Sbjct: 63 EYLF-NIIRKTEMKIQYGGGVRSIEKVKELIDAGVFRVIVGTQAITNPEFLEELSTLNEG 121 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 + AD +V+A+DV +DE + SGW E+S + L + ++ L +G LCTDIS Sbjct: 122 KIKY--ADHIVIAIDV-LDEV----IKYSGWLESSPIKLIEYIDKCLALGFYRFLCTDIS 174 Query: 175 RDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKF 233 +DG L G+ V LY+++ P + SGGI +DD+ L+ G + +VG+A+ E + Sbjct: 175 KDGKLGGAGVELYKKLLDHSPIIKLIGSGGISSMDDIRKLQELGRMESCVVGKAIYENRI 234 Query: 234 TVKEAIACWQ 243 +++E I W Sbjct: 235 SIEE-IQDWN 243 >UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Bacillales RepID=HIS4_BACLD Length = 245 Score = 145 bits (366), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 92/241 (38%), Positives = 137/241 (56%), Gaps = 10/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G VRL QGDY K+ YG+ PL +A +GA +HLVDL GA++ K Sbjct: 6 VYPAIDIRNGKCVRLIQGDYEKETIYGHSPLEMASRFAEEGASWIHLVDLDGAREGKKVN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ ++V VQVGGG+R+E+DV L GV RV++GS+AV + + VK + +G Sbjct: 66 GGHVISIADKLDVKVQVGGGIRTEKDVYDYLSQGVERVILGSSAVSNTEFVKKMLKAYGG 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LD R + V+ GW E S V E+L G + + TDI+ DG L+G Sbjct: 126 H-IAIGLDAR-----DGFVSTEGWLETSSVRAEELGRELANEGAEVFIFTDIATDGMLSG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKEA 238 N++ E+ AR +SGG+ + D+ AL GV G IVG+AL +FTV EA Sbjct: 180 PNINSTVEL-ARATGKQVIASGGVSSLADLEALASRASEGVSGAIVGKALYTNQFTVAEA 238 Query: 239 I 239 + Sbjct: 239 L 239 >UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Bacteria RepID=HIS4_LISW6 Length = 240 Score = 145 bits (365), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 86/246 (34%), Positives = 137/246 (55%), Gaps = 11/246 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL +G VRL QGD+ K+ DP+ + + +A GA LH+VDL GA + Sbjct: 3 IFPAIDLKNGQCVRLFQGDFSKKMIVNEDPIAQAKAFATGGATYLHIVDLDGALEGRPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + VPVQVGGG+RS V L++G+ RV++GS A+ + D + +++G Sbjct: 63 LEIIQKMKEAATVPVQVGGGIRSLAQVDYYLDSGIDRVIIGSAALTNPDFLHAAVQKYGP 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + N VA SGW E S V+ L + VG++ ++ TDISRDGTL G Sbjct: 123 K-IAVGIDAK-----NGYVATSGWLEVSQVNYLDLAKQMEKVGVETIIYTDISRDGTLTG 176 Query: 182 SNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 N+ E++ A ++ + +SGG+ D+ AL G+ G I G+AL G ++ + Sbjct: 177 PNL---EQMAALQKHVNIHLIASGGVSSRADLEALSQLGLYGAIAGKALYNGHISMSDVT 233 Query: 240 ACWQNA 245 +A Sbjct: 234 EVENHA 239 >UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Coriobacteriaceae RepID=C8WPG6_EGGLE Length = 257 Score = 144 bits (363), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 87/243 (35%), Positives = 140/243 (57%), Gaps = 10/243 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D++ G VRL +GDY + Y +DP + Q + QGA LH+VDL GA+ Sbjct: 3 LLPAIDILGGKAVRLAKGDYDRVTVYHDDPAAQAQLFEEQGATWLHVVDLDGARSGIPEN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ ++ + V+VGGGVRS + +A L +AGV+RVV+G++ V D + ++G Sbjct: 63 IAIVERIMRKTLLKVEVGGGVRSLDTIARLADAGVSRVVLGTSLVADPDFAEAAIAQYGK 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 L ID +G +VAV+GW+E +GV+ E+L +G +H++ TDI+RDG G Sbjct: 123 -----LLCAGIDAKGG-EVAVAGWREGAGVAAEELARDMSALGFRHLVYTDIARDGMQTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR--GTGVRGVIVGRALLEGKFTVKEAI 239 + Y + + +SGG+ +DD+ L + GVI GRA+ EG +V+E + Sbjct: 177 IEAAAYVRMAEAFGHPVI-ASGGVAGVDDIVRLGEVAGSIEGVIAGRAVYEGALSVQEGV 235 Query: 240 -AC 241 AC Sbjct: 236 RAC 238 >UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=12 Tax=Bacteria RepID=HIS4_BRAHW Length = 238 Score = 144 bits (363), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 77/238 (32%), Positives = 136/238 (57%), Gaps = 7/238 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL +G VVRL +G+Y + Y DPL L + G+ LH+VDL GA D Sbjct: 3 ILPAIDLKNGEVVRLVEGNYDNKTTYFKDPLEVLDFFIESGSSYLHVVDLDGASDGETIN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ ++ ++ V+VGGG+R+E+ + L+ GV R ++G+ AV++ D ++ Sbjct: 63 FKTIEKVIKKCDLFVEVGGGIRNEDTIKKYLDIGVKRTILGTAAVENIDFTNNMINKY-K 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +++D R ++ +AV GW+E + + +G+ ++ TDIS+DG L+G Sbjct: 122 EHIAVSIDSR-----DRMIAVKGWKEINKQDSVEFCMKLDSMGIDTIIYTDISKDGKLSG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 +N+ +Y+E+ + +SGG+ D++ LR + G IVG+A+ EGK +K+ I Sbjct: 177 TNLDIYKELREKIS-CNIIASGGVTFEDEIIKLRDMKINGAIVGKAIYEGKIDLKKII 233 >UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Deinococcus RepID=HIS4_DEIGD Length = 243 Score = 144 bits (362), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 89/233 (38%), Positives = 132/233 (56%), Gaps = 7/233 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIP +D+ G VRL++GD ++ Y PL + +AA GA ++HLVDL A + Sbjct: 11 LIIPCVDIQSGRAVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDAATGRGEN 70 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I + A + VPV+VGGG+R ALL+AGV RVV+G+ AVK+ +V+ G Sbjct: 71 R-AVITQITAELGVPVEVGGGIRDRAAAEALLDAGVGRVVIGTAAVKNPALVRELIAAHG 129 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V++LD R VA+ GW E SGVS+ +L GL+ ++ TD++RDGTL Sbjct: 130 PSRVVVSLDAR-----GLDVAIHGWAEGSGVSVAELAPLLAEAGLETLIFTDVTRDGTLR 184 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G + L +V + GG+ +DDV L G++G IVGRA+ EG Sbjct: 185 GLDRDLMRQVRQLWSNTLI-VGGGVATLDDVRLLAEEGIQGAIVGRAIYEGTL 236 >UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUX9_ALIAD Length = 252 Score = 144 bits (362), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 95/239 (39%), Positives = 132/239 (55%), Gaps = 11/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD---PA 58 + PA+D++ G VVRL QGDY + Y DP GA LH+VDL A+ Sbjct: 8 VYPAIDILGGEVVRLRQGDYQQVTRYDGDPAGVAGRLCDAGARFLHVVDLDAARSGQSDN 67 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 +R + I A VQVGGG+R+++ +A LEAGVARVV+G TAV+ ++V W + Sbjct: 68 ERAVRAIVETAASYGAAVQVGGGIRTKDAIARWLEAGVARVVIG-TAVRQVEVVAEWAQE 126 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 FG LV LD R ++AVSGW E + S+ L VGL L TD+ RDGT Sbjct: 127 FGGHRLVAGLDGR-----KGRLAVSGWLEETEWSIFDLARELAKVGLVQALVTDVERDGT 181 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N+ L + + + +SGGIG IDDV A+R G+ G ++G+AL +G+ + E Sbjct: 182 GEGPNLDL--ALGVQETGLFAIASGGIGSIDDVVAVRRAGLAGAVIGKALHDGRIHLGE 238 >UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HIS4_RUBXD Length = 243 Score = 142 bits (358), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 105/242 (43%), Positives = 142/242 (58%), Gaps = 10/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL G VRL QGD+G++R Y DP+ R +++ +GA LH+VDL GA++ Sbjct: 8 VVFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPV 67 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ LI+ + VP+QVGGG+R+ EDV A AG ARVVVG+ AV +D E G Sbjct: 68 QLALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELG 127 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 AD LV+A+D R VA GWQ SGV +L G++ VL TDISRDGT Sbjct: 128 AD-LVVAVDAR-----EGVVATHGWQRQSGVGAAELAGELAAEGVRAVLFTDISRDGTGE 181 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAI 239 G+ + EV P +A SGG+ D+ AL R GV G +VG AL EG+ T++E + Sbjct: 182 GAALERTAEVAGIIPTIA---SGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLEELL 238 Query: 240 AC 241 A Sbjct: 239 AA 240 >UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Thermus RepID=HIS4_THET2 Length = 235 Score = 142 bits (358), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 88/243 (36%), Positives = 137/243 (56%), Gaps = 10/243 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL G VRL++GD ++ YG DP+ + +GA +LHLVDL A + + Sbjct: 3 LIPAVDLKSGKAVRLYEGDPARETPYG-DPVEAALRFQEEGATLLHLVDLDRALGTGENR 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ + A +++P Q+ GG+RS E + L G +R VVG+ AVK ++ E G Sbjct: 62 -EAVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGP 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D L +ALD R +V VSGWQE + S L+ + +G++ +L TD+ RDGTL G Sbjct: 121 DRLAVALDAR-----GLEVVVSGWQEAASASALDLLRAWAEMGVRTLLYTDVRRDGTLLG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + + V A +P GGI +D+ L+ GV G ++G+AL EG+ +KEA+ Sbjct: 176 LDREVVARVRAAWPH-ELIVGGGIASPEDLHLLQALGVDGALIGKALYEGRIRLKEAV-- 232 Query: 242 WQN 244 W++ Sbjct: 233 WRS 235 >UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Bacilli RepID=HIS4_STRSV Length = 242 Score = 142 bits (358), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 79/236 (33%), Positives = 129/236 (54%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+D+ DG VRL +GD+ ++ D L + + + G ++H+VDL GA + Sbjct: 5 ILPAIDIKDGQAVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALEGRAAN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI + A + +QVGGG+RS E + L G+ RV++GS AVK+ + V+ ERFG+ Sbjct: 65 RDLIAQIKAETGLAIQVGGGIRSLEQIEDYLAVGIDRVIIGSMAVKNPEFVEAALERFGS 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+ +D + VA GW E S L +G++ + TD+ RDGTL G Sbjct: 125 GKIVIGIDAK-----EGLVATEGWLETSNQDYISLALAMEKIGVRLFVYTDVDRDGTLTG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 N+ Y+++ A +SGGI DD+ ++ G+ G IVG+A G+ ++++ Sbjct: 180 PNIQHYQKLLASLKHAQVIASGGIQSADDLEEMKKLGLAGAIVGKAYYSGRISLEQ 235 >UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Listeria grayi DSM 20601 RepID=C2BYH3_LISGR Length = 240 Score = 142 bits (357), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 89/240 (37%), Positives = 132/240 (55%), Gaps = 11/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G VRL+QGD+ K+ DP+ + +AA GA LH+VDL GA Sbjct: 3 IFPAIDIKNGKCVRLYQGDFAKETMMNADPIDQAAKFAAAGATFLHIVDLDGAVSGKPTN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I LI+ L V +P+QVGGG+R+ V L AG RV++GS A+ D VK ++G Sbjct: 63 IALIQRLQQQVKIPIQVGGGIRTMTQVDTYLRAGAERVIIGSAALSDPDFVKAAVTKYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D +++ +D + N VA GW + S +G+ ++ TDIS+DGTLAG Sbjct: 122 DKIIIGIDAK-----NGFVATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDISKDGTLAG 176 Query: 182 SNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 N +EE+ A + ++A +SGG+ D+ L G G I G+AL EGK T+ + + Sbjct: 177 PN---FEELRAIQKSARIAVIASGGVSSKADLEQLAAEGFYGAIAGKALYEGKITMADVL 233 >UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Faecalibacterium prausnitzii M21/2 RepID=A8S9L9_9FIRM Length = 239 Score = 141 bits (356), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL G VVRL QGDY + YG DP + + + A GA+ LH+VDL GAKD Sbjct: 3 LFPAIDLRGGQVVRLTQGDYDRMTVYGQDPCAQARSFVAAGAKNLHVVDLDGAKDGTLSN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I L + ++VGGG+R+EE + L GV R ++GS AV +++G Sbjct: 63 YDTIAALAKQGGLYIEVGGGIRTEERIEKYLSLGVGRCILGSVAVTDFAFTARMLQKYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D + + VA+ GW+E S + G ++ TDI+ DG + G Sbjct: 122 DKIAVGVDAK-----DGYVAIHGWKEVSAEPGVAFCKRLAEAGCTAIIYTDIACDGAMQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +N+SLY ++ A P VAF +SGGI ++ L+ G I+G++L G + + Sbjct: 177 TNLSLYRQLAAEVPGVAFTASGGISSEAELLELQQMGTAAAILGKSLYTGALDLARCVQL 236 Query: 242 WQN 244 Q+ Sbjct: 237 VQD 239 >UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Halobacteriaceae RepID=HIS4_HALWD Length = 245 Score = 141 bits (355), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 86/245 (35%), Positives = 139/245 (56%), Gaps = 12/245 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG VV+L QG+ G + YG DP+ + + GA+ LHLVDL GA + + Sbjct: 10 VIPAVDMQDGDVVQLVQGERGTETRYG-DPVVAAKQWVEAGAKTLHLVDLDGAFEGDRMN 68 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V++PVQ+GGG+R+ D A+LL+ GV RV++G+ AV++ D+V E + Sbjct: 69 ATAVDAIIDAVDIPVQLGGGIRTANDAASLLDRGVNRVILGTAAVENPDLVAELAESYPG 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++++LD + +V VSGW E++G+ + G +L TD+ +G LAG Sbjct: 129 -RIIVSLDA-----ADGEVVVSGWTESTGIDPAVAAARFADYGACGILFTDVDVEGKLAG 182 Query: 182 SNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 S+ V P +A SGG+ +DD+ L TG +VG AL E KFT+ +A+ Sbjct: 183 IQSSVTARVIDAVDIPVIA---SGGVASLDDIQTLHTTGAAATVVGTALYENKFTLADAM 239 Query: 240 ACWQN 244 ++ Sbjct: 240 EVCES 244 >UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Nannocystineae RepID=D0LIZ1_HALO1 Length = 239 Score = 140 bits (353), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 88/242 (36%), Positives = 135/242 (55%), Gaps = 11/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL+ G VVRLHQG + Y N+P ++ +A+ GAE +H+VDL GA + Sbjct: 3 IYPAIDLLGGNVVRLHQGKRSEALVYSNEPAEIVRRFASAGAERVHVVDLDGAFSGERAH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + A VP+QVGGG+R + A+ G V+G+ AVK+ + E A Sbjct: 63 REALAEMAAASPVPLQVGGGIRDRAALEAVFATGAGFAVLGTAAVKNPAFAR---EACAA 119 Query: 122 D--ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 +++A+D R + VA+ GW E++G++ E+L + G +L TD+ RDG Sbjct: 120 HPGCVIVAVDAR-----DGVVAIEGWVESAGITAEELGKRAADWGAAGLLYTDVMRDGAQ 174 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N++ + A+ + +SGG+G +DD+ AL GV V+VGRAL E KFT+ EA+ Sbjct: 175 VGPNIATTAAL-AQAVDIPVIASGGVGTLDDIRALAAAGVPSVVVGRALYENKFTLPEAL 233 Query: 240 AC 241 A Sbjct: 234 AA 235 >UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Euryarchaeota RepID=HIS4_METBU Length = 246 Score = 139 bits (351), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 83/243 (34%), Positives = 139/243 (57%), Gaps = 13/243 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ G V+L QG G + +DP+ D+ +QGA LHL+DL GA + + Sbjct: 5 VIPAVDMKGGKCVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIEGNRTN 64 Query: 62 IPLIKTLVAGVN---VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 P+IK +V + +QVGGG+RS ED A LL+ G+ +V++ + A+K +++K + Sbjct: 65 APIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLLDIGIDKVILSTAALKDPELIKKLSDE 124 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 FG++ + +ALD + N ++++ GW + S + ++ + G +L T+I +G Sbjct: 125 FGSEHINVALDSK-----NGKISIEGWTKESEHTAVEMGSQFEEKGAGSILFTNIDSEGL 179 Query: 179 LAGSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 L G N EE+ P +A SGG+ ++D+ L+ TG GV+VG AL + +FT+ Sbjct: 180 LNGVNPKPTEELVNAVTIPVIA---SGGVTTLEDIVTLKNTGAAGVVVGSALYKKRFTLT 236 Query: 237 EAI 239 EAI Sbjct: 237 EAI 239 >UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sibiricum 255-15 RepID=B1YL10_EXIS2 Length = 234 Score = 139 bits (351), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 86/238 (36%), Positives = 137/238 (57%), Gaps = 9/238 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL+ G VRL QGD+ +Q +G D L + + GA +HL+DL GAK Sbjct: 3 LYPAIDLMSGQAVRLKQGDFQQQTFFG-DALTIARRFKEDGATAIHLIDLDGAKAGEPLH 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI + + V+ GGGVR+ E V A + AG+ R+++G+ A++ + +++ ER G Sbjct: 62 LSLIADIKKETGLFVEAGGGVRNIETVEAYVGAGIDRILIGTVALEDEALLEQMIERAG- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D L +ALD + + V GW E S +LE+ +E + G+K L TDISRDG + G Sbjct: 121 DKLAVALDAK-----DGIVQTRGWLEASDWTLERAIEHLIQKGIKTFLYTDISRDGMMQG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 +V + + V +SGG+ ++DVA L+ G+ G ++GRALL+G ++KE + Sbjct: 176 PDVDGLD--LLKRDGVELIASGGVTTVEDVARLKEIGMDGAVIGRALLDGSLSLKEVL 231 >UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Proteobacteria RepID=HIS4_NITSB Length = 238 Score = 139 bits (351), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 83/244 (34%), Positives = 133/244 (54%), Gaps = 10/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL DG VRL +G + Y ++P + + G+ LHLVDL GA + Sbjct: 3 ILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEPKN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + IK + A ++ +++GGG+R EE + ++ G+ R+++GS AVK+ VK ++ Sbjct: 63 LEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKYPI 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + A+D VAV GW + S + L + G++ ++CTD+ +DGTL+G Sbjct: 123 AVGIDAID--------GFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVGKDGTLSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 NV + A + +SGG+ DI+D+ L+ TG V GVIVG+A EG ++EA Sbjct: 175 VNVDFTVSI-AEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLDLEEAFR 233 Query: 241 CWQN 244 QN Sbjct: 234 LVQN 237 >UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y7T0_9BACT Length = 237 Score = 139 bits (351), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 84/243 (34%), Positives = 129/243 (53%), Gaps = 7/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL G VRL +GDY + Y + P D+AAQGA LHL+DL GAK+ Sbjct: 2 LIYPAIDLYAGQAVRLQRGDYARMTVYSDRPETVAADFAAQGARQLHLIDLEGAKNGGTP 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I + + QVGGG+RS + + A L+AGV RV++G+ A R+G Sbjct: 62 NLETIVAVKKSSGLFCQVGGGIRSMDAIVAYLDAGVDRVILGTAAATQAHFAARAVARYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A + + +D++ + AV GW E S + + G+ ++CTDISRDG + Sbjct: 122 AR-IAVGVDIK-----DGFAAVKGWTEKSPLKAFEFCRRMQSDGVSTLICTDISRDGMMQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+NV+LY+ + ++ +SGG+ +DDV L G+ G I+G+A ++ AI Sbjct: 176 GTNVALYKTLSTEL-KMRIIASGGVSSLDDVRRLAALGLYGAIIGKACYTKAISIAAAIE 234 Query: 241 CWQ 243 Q Sbjct: 235 VTQ 237 >UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVE8_9SPHI Length = 244 Score = 139 bits (350), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 69/236 (29%), Positives = 124/236 (52%), Gaps = 3/236 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP++ LI+G VRL +GD+ + N+PL Q + + G + LHLVDL GA+ + Sbjct: 4 VIPSIWLINGKCVRLKRGDFATEEAISNNPLEIAQGFESIGIKRLHLVDLDGARRGEPKN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + N+ V GGV ++ DV E G V + S A + + +G Sbjct: 64 YHILEAIAGYTNLHVDFTGGVTTDGDVIKSFEFGAKTVTISSAAANYPERFSQFILSYGR 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LA D ++++ + GW + + + L +E + GLK++ C+D++RDG + G Sbjct: 124 EKINLAADT---NPADRKIKIRGWLKKTEIDLYDHIEFFYDRGLKYLKCSDVTRDGVMVG 180 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 N LY ++ ++P + +SGG+ I+D L+ GV + GRA EG +++ Sbjct: 181 PNFELYADLVKKFPNLNIAASGGVRSIEDFKELKKLGVNAAVFGRAYYEGMLKLED 236 >UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_DESHD Length = 250 Score = 139 bits (350), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 89/243 (36%), Positives = 137/243 (56%), Gaps = 12/243 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL +G VRL QG YG P+ + + QGA+ LH+VDL GA Sbjct: 5 LFPAIDLKEGKAVRLLQGRMEDATVYGEQPVEVARKFKEQGADSLHVVDLDGAFAGKPVN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I L+ + VQVGGG+R+ E + LL+ GV RV++G+ AV++ ++V+ +RF Sbjct: 65 DAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQRF-E 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +A+V+ +D + + VAV GW E + + L VG+KH++ TDISRDG L G Sbjct: 124 EAVVIGIDAK-----DGLVAVQGWAEKTEIKALDLALRMKKVGVKHLVFTDISRDGMLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-----RGTGVRGVIVGRALLEGKFTVK 236 N+ E+ AR + +SGG+ ++D+ L RG + G IVG+AL G F++ Sbjct: 179 PNIQSTVEL-ARLSGLQVVASGGVSRLEDLRLLQEEANRGVSLEGAIVGKALYAGAFSLA 237 Query: 237 EAI 239 EA+ Sbjct: 238 EAL 240 >UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Thaumarchaeota RepID=HIS4_NITMS Length = 236 Score = 139 bits (350), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 80/237 (33%), Positives = 140/237 (59%), Gaps = 8/237 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL+DG VVRL++GD ++ Y +DP+ + + GA++LH+VDL A Sbjct: 3 IIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDL-DATIGTGSN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI+ + +++PV+V GG+R+EE + + RVV+G+ A K ++M++ +++ Sbjct: 62 LDLIEKISKELSIPVEVAGGLRNEEIIDRAISFS-NRVVIGTMAFKDKEMLQRIAKKYDF 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D ID + GWQE++ L + ++ +G L T++S+DGTL G Sbjct: 121 SKIVISVD-HID----GFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVSKDGTLEG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 ++ E+ CA +SGGI +IDDV+ ++ VI+G+AL E K +++EA Sbjct: 176 PDLEYLEKACA-VQNANVIASGGISNIDDVSDVQRKNAFAVILGKALYENKISIEEA 231 >UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Thermoanaerobacter RepID=HIS4_THEPX Length = 235 Score = 137 bits (345), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 80/239 (33%), Positives = 132/239 (55%), Gaps = 8/239 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+++ VRL +GD+ + Y +P+ + + GA+ +H+VDL GAK Sbjct: 2 VLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ ++ ++VGGG+R+ E + L GV V++GS A+ +D++ +G Sbjct: 62 NGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V ID + N +VAVSGW E + + +L + +G+K ++ TDIS+DGTL Sbjct: 122 ERTI-----VGIDSK-NGEVAVSGWLEKTKIKDMELAKKMKEIGVKTIIFTDISKDGTLN 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N E + QV +SGGI I+D+ L+ G G I+G+AL GK K A+ Sbjct: 176 GPNFKALENILKTGVQVI--ASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSAL 232 >UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=HIS4_UNCTG Length = 244 Score = 137 bits (345), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 77/242 (31%), Positives = 141/242 (58%), Gaps = 10/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ G VRL QG+ + Y DP+ + + ++GA+ LH+VDL GA Sbjct: 2 IIIPAVDIRQGNSVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTNI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + A V++PV+VGGG+R+ + + + + G A ++G+ A + ++VK R+G Sbjct: 62 NKAIIKNICAAVDIPVEVGGGIRNMDKIKEVFDIGAAYAILGTVAFNNPEIVKKAITRYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ +++A+D + + +VA+SGW++ + + +LV +G++ +L TDISRDG Sbjct: 122 SEKIIVAVDAK-----DGKVAISGWKDITPIEASELVNKLKEIGVQEILYTDISRDGMFT 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR---GTGVRGVIVGRALLEGKFTVKE 237 G + + +++ ++ +SGG+ ID++ L+ GV IVG AL F +++ Sbjct: 177 GPDFAGLKKLSESGMRII--ASGGVKTIDNLVKLKKYEKDGVFAAIVGSALYTDDFKLED 234 Query: 238 AI 239 AI Sbjct: 235 AI 236 >UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Persephonella marina EX-H1 RepID=HIS4_PERMH Length = 241 Score = 137 bits (344), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 87/242 (35%), Positives = 141/242 (58%), Gaps = 14/242 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IPA+D+ DG VRL++GD YG+DP+ + + +GA+ LH+VDL GA + + Sbjct: 6 FVIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEGKPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I ++K +V V++PV+ GGG+RS E V +++E GV RVV+GS A +++ FER Sbjct: 66 NIDIVKDIVKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQE----FERI- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A + V ID + K VA+ GW E + + + + + L TD++RDG + Sbjct: 121 VSAYPGKVIVGIDAKDGK-VAIKGWLEKTEYTPLDFARMFDDLDIWGFLYTDVNRDGAMV 179 Query: 181 GSNV--SLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGKFTV 235 G N+ + Y ++P +A SGG+G ++D+ L+ GV GV+VG+AL EGK + Sbjct: 180 GPNIEGTKYLAQNLKHPVIA---SGGVGSVEDLKKLYDLKKYGVYGVVVGKALYEGKIKL 236 Query: 236 KE 237 ++ Sbjct: 237 EQ 238 >UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6X1_NATTJ Length = 246 Score = 137 bits (344), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 82/244 (33%), Positives = 138/244 (56%), Gaps = 13/244 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL +G VRL +G+ G ++ Y ++P + + QGA LHLVDL GA + + Sbjct: 5 LIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQGSVKN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ + V++PVQVGGG+RS E + L+ GV +V++G+ A +D ++ E F Sbjct: 65 STIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALELFHK 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + V +D +G K VA GW S + +G+ V+ TDIS+DG L G Sbjct: 125 NII-----VGVDIKGGK-VATEGWVNVSDTKTYDYLSELTELGVPRVILTDISKDGKLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR------GTGVRGVIVGRALLEGKFTV 235 N+ L++E+ A + ++ SGG+ ++D+ ++ + GVI+G+AL EGK + Sbjct: 179 PNLELFKEL-AIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDL 237 Query: 236 KEAI 239 + A+ Sbjct: 238 QGAL 241 >UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Deinococci RepID=C1CY68_DEIDV Length = 251 Score = 136 bits (343), Expect = 6e-31, Method: Compositional matrix adjust. Identities = 83/233 (35%), Positives = 132/233 (56%), Gaps = 7/233 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIP +D+ G VRL++GD ++ Y + PL + + +GA ++HLVDL A + Sbjct: 18 LIIPCVDIQSGRAVRLYEGDPERETVYFDSPLDAARHWVERGAGLVHLVDLDAATGRGEN 77 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I+ + + + VPV+VGGG+R E LL AGV RVV+G+ AV++ +V G Sbjct: 78 R-EVIRQITSELGVPVEVGGGIRDREAAEDLLRAGVHRVVIGTAAVRNPQLVADLIAAHG 136 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V++LD R +VA GW + SGV++ +L GL+ ++ TD++RDGTL Sbjct: 137 PERVVVSLDAR-----GLEVATHGWAQGSGVNVAELTPGLADAGLELLIFTDVTRDGTLK 191 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G N L +V + GG+ ++DDV L+ + G IVGRA+ EG Sbjct: 192 GLNRELMRQVRQLWINTLI-VGGGVANMDDVRLLQEERIEGAIVGRAIYEGTL 243 >UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_CLOK1 Length = 238 Score = 135 bits (341), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 79/246 (32%), Positives = 139/246 (56%), Gaps = 11/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+DL G VRL++GD Q DP + ++GA+ LH+VDL GA + Sbjct: 2 IILPAIDLKGGKCVRLYKGDMNSQEVVARDPFETALKFKSEGAQYLHMVDLDGALKGSGE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I +V V+VP++VGGG+R+ E + ++ GV+RV++G+ A+K++++V E + Sbjct: 62 NLDIISKIVKNVDVPIEVGGGIRNIETIDKFIKLGVSRVILGTAALKNKELVIKAVENYD 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + + A GW S + + +G++ ++ TDIS+DGTL Sbjct: 122 -EKIAVGIDAK-----DGVPAADGWTTLSKTNYIDFGKEMEKIGVQTLIFTDISKDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQ--SSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G+N+ E++ V +SGGI DI+D+ +L+ V G IVG+A+ ++K+A Sbjct: 176 GTNL---EQLLKLKNSVKCNVIASGGIKDIEDIKSLKKENVYGAIVGKAIYAKTLSLKKA 232 Query: 239 IACWQN 244 I N Sbjct: 233 IEIGGN 238 >UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ6_9ACTN Length = 247 Score = 135 bits (341), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 92/249 (36%), Positives = 136/249 (54%), Gaps = 18/249 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGA----KD 56 ++ PA+DLI G VVRL +GD + + Y +DP+ + +A QGA +H+VDL+ A +D Sbjct: 2 ILFPAIDLIGGKVVRLERGDRSRCKVYSDDPVAVARSFAEQGASWVHVVDLSSAFGEDED 61 Query: 57 PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 IK + + V VGGGVRS + L G R+ +G+ V + Sbjct: 62 TCAANSAAIKAICGVDGLSVDVGGGVRSLARIDELAGYGARRIALGTVLVTEPGFAEVAA 121 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 + FG + LV + R + QV V+GW++ +GV+L+ V +G KH++ TDI+RD Sbjct: 122 QGFG-ELLVADIAAR-----DGQVKVNGWRDGAGVALDDAVAQLSELGFKHLVYTDIARD 175 Query: 177 GTLAGSNVSLYEEVC--ARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEG 231 G G +V+ Y V A +P VA SGGI +DD+ AL G + G I GRAL EG Sbjct: 176 GMQTGIDVAAYRHVAEVAGFPVVA---SGGISALDDIRALAAVGEGAIEGAITGRALYEG 232 Query: 232 KFTVKEAIA 240 FT+ +A+A Sbjct: 233 NFTLAQALA 241 >UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Lactobacillus rhamnosus RepID=C7TCJ1_LACRG Length = 249 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 78/236 (33%), Positives = 129/236 (54%), Gaps = 6/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL+ G VRL QGDY +Q DPL ++++ A G + LHLVDL GA+ Sbjct: 3 LYPAIDLLAGQSVRLTQGDY-RQVSLTADPLTQVKNLTATGLKHLHLVDLDGARSQQPIN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I T+ +++GGG+R+ + L AG+ R+++GS AV + ++V ++FGA Sbjct: 62 QAVISTIRQHTPAFIELGGGIRTLAIMDHYLNAGIDRLILGSVAVTNPELVTQAVQKFGA 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D R + VA GW S S L++ + G+ + TDI RDG + G Sbjct: 122 DKIAVGIDARAGK-----VATDGWLTTSTQSPTHLMQAMVRRGVTTFIVTDIGRDGMMKG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 NV+L + P V +SGG+ + D+ AL+ G++ ++G+A G F + + Sbjct: 177 PNVALLAMLHQTVPNVNIVASGGVHTLADLTALQTAGIQAAVIGKAWQTGSFPLNK 232 >UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3165B Length = 246 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 85/246 (34%), Positives = 139/246 (56%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+D+ G+ VRL QGD+ + Y DPL + + GA LH+VDL GA+D Sbjct: 2 ILYPAIDIRGGSAVRLRQGDFADETVYDADPLSAARAWVEGGARWLHVVDLDGARDGRPA 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++ + + VPV+ GGG+RS V A +EAG RV++G+ A D + +G Sbjct: 62 NLEHLRRIAGELGVPVEFGGGLRSRASVDAAIEAGAERVILGTAAFADVDFLDDVVAAYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+++DVR +VA +GW+E + + +++ G++ ++ ++I RDG L Sbjct: 122 -ERVVVSVDVR-----GGKVASAGWKEQTEMEAAAVIDHLQRRGVRKLVYSNIERDGMLT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGKFTVKE 237 G ++ V A + +F SGGIG +D +AA LR + GVIVG+AL E KFTV + Sbjct: 176 GPDLDEVRRV-AESVRGSFIYSGGIGSLDHLAALASLRQVNLNGVIVGKALYERKFTVGD 234 Query: 238 AIACWQ 243 A+ + Sbjct: 235 ALTALK 240 >UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=31 Tax=cellular organisms RepID=HIS4_CHRSD Length = 249 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 89/242 (36%), Positives = 130/242 (53%), Gaps = 11/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL DG VRL QG YG+DP+ + GA LHLVDL GA + Sbjct: 2 LVIPAIDLKDGQCVRLKQGRMDDSTTYGDDPVAMAARWVETGARRLHLVDLNGAFEGKPV 61 Query: 61 QIPLIKTLV-AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + A ++P+Q+GGG+R+ E + A LEAGV+ V++G+ AVK V RF Sbjct: 62 NAEAVTAIARAYPDLPIQIGGGIRTAETIEAYLEAGVSYVIIGTQAVKEPAFVGEMCRRF 121 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 +V LD R + VA GW E S + L + + G+ ++ TDI+RDG + Sbjct: 122 PGHVIV-GLDAR-----DGYVATDGWAEVSTLKAVDLAKRFADDGVSSIVYTDIARDGMM 175 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGI---GDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G N++ E+ AR + +SGG+ GDI+ + + G+ G I GRA+ EGK V Sbjct: 176 QGVNIAATAEL-AREGGLPVIASGGVTHLGDIEALLEVADAGILGAITGRAIYEGKLDVA 234 Query: 237 EA 238 EA Sbjct: 235 EA 236 >UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Chlorobiaceae RepID=HIS4_PROA2 Length = 261 Score = 135 bits (340), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 88/250 (35%), Positives = 132/250 (52%), Gaps = 18/250 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ DG VRL +GD+ +Q+ Y ++P + Q A++LH+VDL A Sbjct: 2 LIIPAIDIKDGKCVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGTMV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I+ +VA +++PVQVGGG+RS EDV L GV+RVV+GS AV + ++ F Sbjct: 62 NFEKIREIVATLDIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELLATFS 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D N + GW E+S + +L +G+K ++ TDISRDG + Sbjct: 122 PSQIVVGIDAE-----NGIPKIKGWTESSSMQDYELALEMKKLGVKRIIYTDISRDGMMQ 176 Query: 181 GSNVSLYEEVCARYPQVA---FQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFT 234 G E R+ A +SGG+ DD+ L+ GV VIVG+AL E F Sbjct: 177 GVGY----ESTRRFAMKAGMRVTASGGVTSSDDLKKLQTLEQYGVDSVIVGKALYESNFP 232 Query: 235 VKEAIACWQN 244 ++ W N Sbjct: 233 CQQ---LWYN 239 >UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PWX6_9BACT Length = 243 Score = 135 bits (339), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 81/243 (33%), Positives = 134/243 (55%), Gaps = 17/243 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL G VRL QG ++ + +DP+ + + QGA+ LH+VDL GA D + Sbjct: 2 IIFPAIDLKGGKCVRLTQGKKDEETVFSDDPVDMAKSWEDQGAQYLHVVDLDGAFDGLPK 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ +V +N+P++ GGG+R+ E V ++L+ GV RV++G+ A+ S V+ F Sbjct: 62 NLSIVEQIVNNINIPIEFGGGLRTTESVKSVLDLGVERVIIGTKALDSPSWVEELCSLFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGW---QENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 V +D + N +VAV GW E + + + +E + P ++ TDIS+DG Sbjct: 122 GRVAV-GIDAK-----NGKVAVHGWTSLSEKTAIDFAREMEKFSPCA---IIFTDISKDG 172 Query: 178 TLAGSNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 L G N+ +E+ + + P +A SGGI + D+ + V G+IVG+AL G Sbjct: 173 MLQGPNIESLKELLSSIKTPVIA---SGGISSLKDIEYICQLPVEGMIVGKALYTGHIKF 229 Query: 236 KEA 238 EA Sbjct: 230 SEA 232 >UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrio RepID=HIS4_DESVH Length = 249 Score = 134 bits (336), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 77/243 (31%), Positives = 133/243 (54%), Gaps = 11/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL++G VRL +G + + +DP+ + + QG LH+VDL GA Sbjct: 2 IVFPAIDLMNGVCVRLRRGRADDETVFSSDPVATARHWQEQGGRWLHVVDLDGAFSGQPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 PLI+++ +++PVQ+GGG+R A LEAGV R+++G+ A++ D F Sbjct: 62 NAPLIRSICDALDIPVQLGGGIRDAATAKAYLEAGVERLIIGTIALEEPDAYAALCAEFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V +D +G K + GW +SG+++++++ L G ++ TDI RDG Sbjct: 122 G-----RIGVSLDAEGGK-LKTKGWVADSGLTVDEVLPRLLEAGTAFIIYTDIDRDGMQT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL----RGTGVRGVIVGRALLEGKFTVK 236 G N+ E + A+ V ++GG+ ++DV AL R T ++G + GRA+ EG ++ Sbjct: 176 GVNLPALEHL-AKASTVPVIAAGGVATLEDVKALYPLSRTTNLQGAVSGRAIYEGTLDLR 234 Query: 237 EAI 239 A+ Sbjct: 235 TAM 237 >UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_DESAP Length = 262 Score = 134 bits (336), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 86/243 (35%), Positives = 140/243 (57%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL G VRL QG ++ Y DP+ + + QGA LH+VDL GA + Sbjct: 2 LIIPAVDLRGGRCVRLFQGRADQETVYSTDPVAVARTWEEQGARRLHVVDLDGAFTGKPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ +V VN+PVQVGGG+R+ E+V LE GV RV++G+ A+ + + + +G Sbjct: 62 NSGVVLDIVKSVNIPVQVGGGIRNPENVKCYLEHGVDRVILGTAALTNPEFLDAVVAAYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+ +D R + +V V GW++ + + +E + G++ V+ TD+ RDGTL Sbjct: 122 -ERIVVGVDCR-----DGRVCVQGWEQTAATDVLPFLEELVRRGVRRVVFTDVKRDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKE 237 G N+ V A + ++ +SGG+ ++D+ AL+ GV VI+G+AL G T+ E Sbjct: 176 GPNLEEIARVAA-HTELKVIASGGVSRLEDLRALKKLEHLGVDSVIIGKALYAGTITLAE 234 Query: 238 AIA 240 A+A Sbjct: 235 ALA 237 >UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Euryarchaeota RepID=HIS4_METJA Length = 237 Score = 134 bits (336), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 83/245 (33%), Positives = 139/245 (56%), Gaps = 10/245 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL D V+L QGD K+ N+P+ + + +GAE LH++DL A Sbjct: 2 IIIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAFGTGNN 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +IK ++ VNVPV+VGGG+R+ E L+ GV RV+VG+ A+ + + G Sbjct: 62 R-DVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQEN-SGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 D +VLA++ + +G +V + GW+E +E + E VG ++L T++ +G L Sbjct: 121 KDKIVLAVECK---EG--KVVIKGWKEKVDKTPIEVIKEFEDKVG--YILFTNVDVEGLL 173 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G NV + +E+ + + SGGI ++D+ AL+ G+ GV++G AL +G +K+A+ Sbjct: 174 KGINVDIIKELIEK-TDIPIIYSGGITTLEDIKALKELGIYGVVIGSALYKGLIDLKKAL 232 Query: 240 ACWQN 244 +N Sbjct: 233 EIVKN 237 >UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Leptospirillum RepID=A3EUM5_9BACT Length = 247 Score = 134 bits (336), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 86/241 (35%), Positives = 140/241 (58%), Gaps = 13/241 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G VVRL QG + ++ YG DP+ + +G + LH+VDL GA++ Sbjct: 3 LYPAIDIRNGKVVRLTQGRFDQETVYGEDPVRTALQFRERGVQHLHVVDLDGAREGVPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ +V VQVGGGVRS++ + +AGV+R+++G+ A+K + E+ Sbjct: 63 RSLIREIVKAFRGFVQVGGGVRSKDIASFYYDAGVSRLILGTAAIKDPVFLGSMIEQH-P 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQE-NSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + +DV+ ++ +AV+GW + ++ LE +V +G++ + TDI RDG L+ Sbjct: 122 DLFYVGIDVK-----DESLAVNGWLDLDTQDPLEVMVRMS-ELGVRGFVYTDIHRDGLLS 175 Query: 181 GSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N + YE + R P +A SGG+ DI D+A LR GV G IVG+A+ G+ + EA Sbjct: 176 GPNFARYETLRRTVRVPVIA---SGGVRDISDIARLREIGVDGAIVGKAIYTGEMDLTEA 232 Query: 239 I 239 + Sbjct: 233 L 233 >UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_THEYD Length = 244 Score = 134 bits (336), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 87/239 (36%), Positives = 132/239 (55%), Gaps = 8/239 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL DG VRL QG + + Y ++P + +GAEVLH+VDL GAK+ Sbjct: 3 IIPAIDLKDGKCVRLRQGKFSEVTVYYDNPEDAALRWQNEGAEVLHVVDLDGAKEGKIGN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P IK + ++VGGG+R ED+ LL G+ RV+VG+ AV+S D VK +RF Sbjct: 63 LPSIKKIREAFRGNIEVGGGIRRIEDIELLLSVGIDRVIVGTIAVQSPDFVKEVCKRF-P 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D + + VAV GW E + + +L G+ ++ TDISRDG L G Sbjct: 122 KKIIVGIDAK-----DGLVAVKGWVEVTEIRAIELALKMQDYGIWGIIYTDISRDGMLTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAI 239 N+ + + +V +SGG+ I+D+ L + GVI G+A+ G +KEA+ Sbjct: 177 PNIEATKALVESV-KVPVIASGGVSSIEDIRKLAEIPQLWGVITGKAIYSGAIDLKEAL 234 >UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=23 Tax=Bacteria RepID=HIS4_THEEB Length = 257 Score = 133 bits (334), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 90/250 (36%), Positives = 128/250 (51%), Gaps = 13/250 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL+DG VRL QG+Y K + +DPL + GA LHLVDL AK R Sbjct: 3 VIPAIDLLDGKCVRLVQGNYDKVNVFHDDPLKVALYWQRLGAPRLHLVDLDAAKTGEPRN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI +VA + +PVQVGGG+RS + VA L GV R ++G+ A+++ +V + Sbjct: 63 YDLIGKIVASLEIPVQVGGGLRSRQAVADLFLQGVNRAILGTVALENPKLVASLAAEYPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 V LD R + VA GW E S + L + +G+ + TDI RDGTL G Sbjct: 123 RIWV-GLDAR-----DGYVATRGWLETSKILATDLAQNMAAMGVAGFVYTDIQRDGTLQG 176 Query: 182 SNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 N+ ++ A P +A + DI + AL G+ G IVG+AL ++EA+ Sbjct: 177 PNIPALRQLLAVTNRPVIASGGVSSLNDILSLFALTPHGLVGAIVGKALYTKAMDLREAV 236 Query: 240 AC-----WQN 244 WQ+ Sbjct: 237 RAVGQGRWQD 246 >UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Chlorobiaceae RepID=HIS4_CHLT3 Length = 262 Score = 132 bits (333), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 83/238 (34%), Positives = 134/238 (56%), Gaps = 13/238 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ G VRL +GD+ +++ Y ++P + Q A+++H+VDL A Sbjct: 2 LIIPAIDIKGGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALTGKPE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 IK +V +++P+++GGG+R+ ED A L+ GV RVV+GS AVK+ +V E++G Sbjct: 62 NFDKIKQIVDTLDIPIEIGGGIRTAEDAARYLDIGVYRVVIGSAAVKNPSLVSQLIEKYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D E G + +SGW E+S +L G++ ++ TDI+RDGTL Sbjct: 122 PRKIVVGIDA---EDGIAK--ISGWTESSQKKDYELALEMKDRGVERIIYTDITRDGTLE 176 Query: 181 GSNVSLYE--EVCARYPQVAFQSSGGI---GDIDDVAALRGTGVRGVIVGRALLEGKF 233 G YE + A Q+ +SGG+ D+ + L GV VI+G+AL E +F Sbjct: 177 GVG---YETTKAFAEKAQMRITASGGVFGKQDLSKLCKLEHLGVDSVIIGKALYEERF 231 >UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=104 Tax=Bacteria RepID=HIS4_CLOB1 Length = 242 Score = 132 bits (332), Expect = 9e-30, Method: Compositional matrix adjust. Identities = 74/239 (30%), Positives = 142/239 (59%), Gaps = 7/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+DL +G +RL+QGD+ + DP+ + GAE +H+VDL GA + Sbjct: 2 IILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIK 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I +++ +N+PV++GGG+R+ + L+ AG+ RV++G+ A+ ++ +V+ +++ Sbjct: 62 NLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKYD 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + N++VA++GW S ++ + +G+++++ TDIS+DGTL Sbjct: 122 -EKIAIGIDAK-----NEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLK 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N+ E++ +SGGI DI+D+ ++ V G IVG+A+ G + EAI Sbjct: 176 GPNLKQLEKLNESI-NCNVIASGGIKDIEDLKGIKEMDVYGAIVGKAIYSGNINLNEAI 233 >UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U8M5_HYDS0 Length = 234 Score = 132 bits (332), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 80/238 (33%), Positives = 135/238 (56%), Gaps = 13/238 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ DG VVRL +G + + Y +P+ + + + G +H+VDL GAK + Sbjct: 4 FIIPAIDIKDGAVVRLKEGKFENVKVYRQNPIDQFKLFVDLGFTRIHIVDLDGAKVGIPK 63 Query: 61 QIPLIKTLVAGVN-VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + L++ ++ N V++GGG+RS E AL E G ++VG+ AVK ++ E + Sbjct: 64 NLKLLEDMLKQKNDAKVEIGGGIRSLETAKALFEIGADYIIVGTLAVKDKEEFIRLLELY 123 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 D ++L++D + N +VA+ GW+E S +S + Y ++ L T+I+ DGTL Sbjct: 124 -KDRIILSVDAK-----NGKVAIGGWEEESSISPCDMARIYDNYPIESYLYTNINIDGTL 177 Query: 180 AGSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 G +++ Y++ C P +A SGG+ ++DV L+ T V GV+VG+A+ E K + Sbjct: 178 TGVDINPYKDFKKCTTKPIIA---SGGVASLEDVIKLK-TVVNGVVVGKAIYENKIDI 231 >UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9Y4_9FIRM Length = 245 Score = 132 bits (331), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 80/246 (32%), Positives = 132/246 (53%), Gaps = 20/246 (8%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL G VRL +G++ K+ Y DP + +A GA +H+VDL GA Sbjct: 6 LYPAIDLRGGMCVRLEKGNFSKETVYSKDPGAMARRFAEAGARTIHVVDLDGALAGKSEN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + IK ++ + ++VGGG+R+ E + LL GV++V++GS A+ +V ER Sbjct: 66 LSAIKAILREGGISIEVGGGIRTYEQIEGLLSLGVSQVILGSAAIYDPQLV----ERANR 121 Query: 122 D---ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 D +V+ +D + N A GW+++S ++ E L G + ++ TDISRDG Sbjct: 122 DFPYKIVVGIDAK-----NGYAAADGWEKDSNLTAEALARRVAAAGTERIIFTDISRDGM 176 Query: 179 LAGSNVSLYEEVCARYPQ--VAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKF 233 + GSN+ E A Y V +SGG+ ++D+ L+ G+ G I+G+AL G F Sbjct: 177 MNGSNI---EATAALYQACGVPITASGGVSSLEDIRRLKARETDGIEGCIIGKALYAGAF 233 Query: 234 TVKEAI 239 ++ +A+ Sbjct: 234 SLSDAL 239 >UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Clostridia RepID=HIS4_SYNWW Length = 244 Score = 131 bits (329), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 85/242 (35%), Positives = 133/242 (54%), Gaps = 9/242 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL QG + Y + P + + QGA LH+VDL GA + + Sbjct: 2 IIYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I+ + A +++ QVGGG+R DV LL G +RV++G+ AV D + ++FG Sbjct: 62 NLKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VL LD + VAV GW S VS +G++ + TD+SRDG L Sbjct: 122 PERIVLGLDAK-----EGMVAVEGWVSTSSVSAIDFGLQMKALGIQTAIYTDVSRDGLLQ 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR---GTGVRGVIVGRALLEGKFTVKE 237 G N++ +E+ A + +SGG+ +D++ AL+ GV G I+G+AL +GK + + Sbjct: 177 GPNLAAIKEM-ASSTGLDIIASGGVSSLDNIRALKELENDGVSGAIIGKALYDGKIGLVD 235 Query: 238 AI 239 A+ Sbjct: 236 AL 237 >UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZVN4_9SPHI Length = 246 Score = 130 bits (328), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 69/236 (29%), Positives = 127/236 (53%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P++ ++ G VVR +GD + + Y +PL ++ G + LHLVDL GAK Sbjct: 4 IVPSIAILGGKVVRTIKGDIDQVQVYDTNPLDLALEFENNGIKHLHLVDLDGAKARQIVN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ L + + + GG+ ++D+ E G V + AV ++ W +G Sbjct: 64 YNILEMLASYTQLEIDYTGGITRDDDIRTAFECGAKHVTAATVAVHEREKFLSWVITYGG 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++LA D + V GW++N+G+ L + +++Y G++ V T+I R+GTL G Sbjct: 124 NKVILAADAL-----DGVVLTKGWRKNTGIDLVEHIKSYHERGVRFVKTTEIGRNGTLEG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 N Y+++ +P++ +SGGI I+D+ L GV GVI+G++ +G+ +K+ Sbjct: 179 PNFDTYKKLRTEFPELQILASGGIRSIEDIEQLDALGVAGVIIGKSYYDGQIKLKD 234 >UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Planctomycetaceae RepID=A6C5Q1_9PLAN Length = 246 Score = 130 bits (328), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 90/248 (36%), Positives = 135/248 (54%), Gaps = 19/248 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+D+ G VRL QGDYG++ +G+DP + +A GA+ LHLVDL GAK Sbjct: 3 ILPAIDIRGGKCVRLRQGDYGQETVFGDDPTEMARRWADGGAQRLHLVDLDGAKAGQPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALL-EAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ +V V+VP Q+GGG+R E + +L E G+ RV+VG+ A+K K +R+ Sbjct: 63 HEVVRKIVEAVSVPCQMGGGIRDEASIQLMLDEVGIDRVIVGTQALKDPQWFKQMVQRY- 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + L L LD R + +VA GW + S S L + Y+ V L V+ T+I+ DG + Sbjct: 122 PNRLALGLDAR-----DSKVATEGWLDVSETSAIDLAKEYVGVELAAVIYTNIANDGMMQ 176 Query: 181 GSNVSLYEEVCAR----YPQVAFQSSGGIGDIDDVAALRGTG-----VRGVIVGRALLEG 231 G + +++ A P +A SGG+ + DV+ L + G I+GRAL EG Sbjct: 177 GVDEGTIQDMIALAELGLPVIA---SGGVTTLKDVSRLAEVSRTQPKLVGAIIGRALYEG 233 Query: 232 KFTVKEAI 239 V AI Sbjct: 234 TIEVPAAI 241 >UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Caulobacter RepID=HIS4_CAUSK Length = 241 Score = 130 bits (328), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 83/241 (34%), Positives = 131/241 (54%), Gaps = 8/241 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL DG VRL GD K + N P + + + G LH+VDL GA + Sbjct: 2 ILYPAIDLKDGQCVRLLHGDMEKATVFNNSPADQAERFVRDGFSWLHVVDLNGAIEGKSV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++++ +++PVQ+GGG+R+ E V A +EAGV+RV++G+ AV D+V+ R Sbjct: 62 NTAAVQSILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPDLVRK-AARLW 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +A+DVR + +VAV GW S + L + + VG+ ++ TDISRDG L Sbjct: 121 PEQIAVAVDVR-----DGKVAVDGWTGLSDLDAITLGKRFEDVGVAALIVTDISRDGALT 175 Query: 181 GSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G NV E+ P +A + DI+ + A G + G I+GR+L G EA Sbjct: 176 GVNVEGVGELADAVSIPVIASGGVASVADIERLKARPGVEIAGAILGRSLYAGTIRPAEA 235 Query: 239 I 239 + Sbjct: 236 L 236 >UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomycetales RepID=D2Q1W2_9ACTO Length = 256 Score = 130 bits (326), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 85/242 (35%), Positives = 135/242 (55%), Gaps = 13/242 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+D+ DG VRL QG+ G + YG DPL + GAE +HLVDL A Sbjct: 17 VLLPAVDVADGQAVRLVQGEAGSETSYG-DPLAAATAWQEAGAEWIHLVDLDAAFGRGSN 75 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + L+ + ++V V++ GG+R +E + A L G RV +G+ A++ + + +G Sbjct: 76 R-ELLADVTGRLDVQVELSGGIRDDESLEAALATGARRVNIGTAALEDPEWCDRVIQTYG 134 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + LDVR + +A GW + G L +++E G + + TD+++DG L Sbjct: 135 -DRVAIGLDVR-----GRTLAARGWTKEGG-DLYEVLERLERAGCERYVVTDVTKDGMLQ 187 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKE 237 G N+ LY ++CAR + +SGG+ +DD+ AL GV GVIVG+AL G FT+ E Sbjct: 188 GPNLDLYRDLCARTAK-PIVASGGVSSLDDLRALATLVPDGVEGVIVGKALYAGAFTLTE 246 Query: 238 AI 239 A+ Sbjct: 247 AL 248 >UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Proteobacteria RepID=HIS4_DESOH Length = 251 Score = 130 bits (326), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 94/243 (38%), Positives = 132/243 (54%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IPA+D+ G VRL QGD + + +DP + +A GAE++H+VDL GA + + R Sbjct: 2 MVIPAVDIKGGKCVRLLQGDMNAETVFSDDPGAMAERWAEAGAELIHVVDLDGAIEKSPR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I L+ V VPVQVGGG+R + V + GVAR+V+GS AV D+V F Sbjct: 62 NLKAISALIRRVGVPVQVGGGIREIDTVKMYADLGVARIVIGSAAVNHPDLVTAACREFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +VL +D R + +VA GW + ++ L + G+ + TDI RDG Sbjct: 122 GR-IVLGIDAR-----DGRVATEGWTSTTDIAAADLAARFEGCGVAAINFTDIHRDGMRT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N+ E AR + +SGG+ IDD+ AL G GV GVI GRAL +G + E Sbjct: 176 GPNIPAIEAF-ARATAIPVVASGGVSTIDDIQALLGIQEFGVTGVITGRALYDGTLDLAE 234 Query: 238 AIA 240 AIA Sbjct: 235 AIA 237 >UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=root RepID=HIS4_PELUB Length = 239 Score = 129 bits (325), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 77/241 (31%), Positives = 131/241 (54%), Gaps = 12/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ D VRL +GD+ + +Y P+ + Y G + LH+VDL GA Sbjct: 3 IFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGETVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +IK +V ++ ++VGGGVRS + + + AGV +V++GS A+K+++ +K ++F Sbjct: 63 LDIIKEIVHKFDLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKF-P 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + L LD + + ++VSGW+ENS ++ G ++ TDI+RDGT Sbjct: 122 NKIALGLDAK-----DGYLSVSGWKENSNQLTLDFLKEVNDYGASRLIYTDINRDGTKES 176 Query: 182 SNVSLYEEVC--ARYPQVAFQSSGGIGDIDDVAALRG-TGVRGVIVGRALLEGKFTVKEA 238 N +EE A SGG+ IDD+ +G + G+IVG+A+ +G ++E Sbjct: 177 PN---FEETTNVANVSNCPVIISGGVSSIDDIKKAKGLKNIEGIIVGKAIYDGDIKLEEL 233 Query: 239 I 239 + Sbjct: 234 V 234 >UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CARHZ Length = 243 Score = 127 bits (319), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 81/248 (32%), Positives = 132/248 (53%), Gaps = 14/248 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL+ VVRL QG+ ++ +Y P+ Y GA ++H+VDL A Sbjct: 2 ILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I ++ V++PVQVGGG+R E L++ GV+RV+VG+ AV + ++++ Sbjct: 62 NFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEML-TLD 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + +D + N VA+ GW E+S L +G+ ++ TDI+RDG+L Sbjct: 121 RDKVAVGIDAK-----NGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARDGSLT 175 Query: 181 GSNVSLYEEVCARYPQVAFQ--SSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKFTV 235 G N + E + +SGGI ++D+ R G + GVI G+A+LEGK + Sbjct: 176 GPN---FNETLKLAIDTGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDL 232 Query: 236 KEAIACWQ 243 KE I + Sbjct: 233 KEGIRILE 240 >UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrionales RepID=HIS4_DESDA Length = 250 Score = 126 bits (317), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 84/253 (33%), Positives = 136/253 (53%), Gaps = 20/253 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ +G VRL QG + + P+ + + GA LH+VDL GA D A + Sbjct: 2 IIFPAVDIQNGKAVRLKQGRAHESTVFAESPVDAARAWEEAGARWLHVVDLDGAFDGAAQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKS----QDMVKGWF 116 +++ + A + +PVQ+GGG+R A LEAGV+R+++G+ A++ DM + + Sbjct: 62 SRRIVRDICAALAIPVQLGGGIRDMHTAEAYLEAGVSRLIIGTLALEQPTLFADMCRAFP 121 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 R G V +D +G + + GW E++G++++ + L G V+ TDI RD Sbjct: 122 GRVG---------VSLDAEGGR-LKSRGWVEDTGMTVDTALPRLLDDGAAFVIYTDIERD 171 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG----TGVRGVIVGRALLEGK 232 G G NV+ E + AR V ++GG+ ++D+ L T + G + GRAL EG Sbjct: 172 GMQCGVNVAALEHL-ARLSTVPVIAAGGVATLEDIQKLYPLTLETSLMGAVSGRALYEGT 230 Query: 233 FTVKEAIACWQNA 245 +KEA A W +A Sbjct: 231 LDLKEANA-WIDA 242 >UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQP1_9RICK Length = 238 Score = 125 bits (315), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 74/240 (30%), Positives = 132/240 (55%), Gaps = 8/240 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL +GD+ +Q Y P+ + + + +G E LH+VDL K Sbjct: 2 IIYPAIDLQDGKCVRLTKGDFEQQTVYSRSPIEQAKAFEDKGFEFLHVVDLDRTIHKEKS 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + IK ++ + VQVGGG+R+++ V +++ GV V+G+ AV D++ +++ Sbjct: 62 NLKTIKEIIQSTGLKVQVGGGLRTKDTVEEVIDLGVENAVMGTAAVNDPDLLIEISQKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + LDVR +K +A+ GW++ + +S +ET + LK ++ TDI++DG Sbjct: 121 KNKISVGLDVR-----DKMIALKGWKDQTEISCFDFLETIKNLPLKSIIFTDINKDGMKQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDD-VAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N+ ++ A + +SGG+ IDD + GV+VG+A+ +G + E + Sbjct: 176 GINIDDTLKM-AESSNIPVTASGGVSSIDDIKLIKSKKKISGVVVGKAIYDGLIDLNELV 234 >UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B860_THEAS Length = 232 Score = 125 bits (313), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 84/239 (35%), Positives = 128/239 (53%), Gaps = 12/239 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL G VVRL G + Y P +A G H+VDL GAK Sbjct: 3 IYPAVDLYGGKVVRLTGGRFQDATVYPTSPGEMALLFAQAGVRWAHVVDLEGAKTGRPVH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAV-KSQDMVKGWFERFG 120 + ++ AG + VQ GGG+RS + V L AG RV++GS +S D+V+ R Sbjct: 63 LWALEAF-AGAGLKVQFGGGIRSIQSVRDALSAGATRVMMGSALFDRSVDVVEA--HRLF 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A++ A+D R +V+V GW + + + +++ +E VG L TD RDGTL+ Sbjct: 120 GPAILPAVDHR-----GWRVSVKGWTQGTDIPVDRALENLSRVGFSLFLVTDGDRDGTLS 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G ++ Y ++CARY +A +GGIG++ + LR G G ++G+AL EG +++EA+ Sbjct: 175 GPDLEGYRKICARYGIIA---AGGIGELGHLRGLRNAGAAGAVLGKALYEGAISIEEAM 230 >UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sp. AT1b RepID=C4L175_EXISA Length = 237 Score = 124 bits (312), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 80/242 (33%), Positives = 134/242 (55%), Gaps = 11/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+DLI G +VRL +GD+ + YG DP L+ + + ++HL+DL GAK R Sbjct: 3 LLPAIDLIGGKIVRLTEGDFSTEEQYG-DPYELLKAWQGK-VPMIHLIDLEGAKAGEPRH 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ + VQ GGG+RSE + A++E G RV++G+ A D + E++G Sbjct: 61 LDVVR-YAKSLGFLVQTGGGIRSEASLDAVMETGADRVLLGTKAFTDPDFLDKAIEKYGK 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 V ALD + +VA++GWQE + + + + + G++ +L TDI DG L G Sbjct: 120 RVAV-ALDAY-----DGKVAINGWQEATKLDDISVAQDLVKRGIETILYTDIGSDGKLNG 173 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV+ + + V +SGG+ +DV L+ + +VG+ALL GK +++E I Sbjct: 174 PNVTRM-KALRQIVNVTLIASGGVTTEEDVKELKMAKIDEAVVGKALLSGKVSIEELIE- 231 Query: 242 WQ 243 W+ Sbjct: 232 WE 233 >UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=209 Tax=Bacteria RepID=HIS4_HERAR Length = 265 Score = 124 bits (312), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 79/251 (31%), Positives = 132/251 (52%), Gaps = 20/251 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL DG VRL QGD + + DP + + QGA LHLVDL GA + Sbjct: 2 LLIPAIDLKDGHCVRLKQGDMDQATVFSEDPADMARHWLEQGARRLHLVDLNGAFAGKPK 61 Query: 61 QIPLIKTLVAGV----------NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 P +K ++ V +PVQ+GGG+R + + L+ G++ +++G+ AVK+ Sbjct: 62 NEPAVKAILQAVREYAEKNGIEEIPVQLGGGIRDLDTIERYLDDGLSYIIIGTAAVKNPG 121 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 + F +++ LD + + +VA GW + SG + L + + G + ++ Sbjct: 122 FLHDACSAFPGQ-IIVGLDAK-----DGKVATDGWSKLSGHEVIDLAKKFEDYGCESIIY 175 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRA 227 TDI RDG + G N+ ++ A+ + +SGG+ +I DV AL + G+ GVI GR+ Sbjct: 176 TDIGRDGMMGGVNIEATVKL-AQSMTIPVIASGGVHNIKDVEALCAVQEEGIEGVICGRS 234 Query: 228 LLEGKFTVKEA 238 + EG ++ A Sbjct: 235 IYEGTLDLRSA 245 >UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Zymomonas mobilis RepID=HIS4_ZYMMO Length = 250 Score = 124 bits (311), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 82/243 (33%), Positives = 128/243 (52%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL +G VVRL +GD + Y +DP R + + GA LH+VDL GA Sbjct: 6 IIFPAIDLKEGHVVRLSEGDMDRATIYDDDPAARARQFYEAGARYLHVVDLDGAFAGHAM 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +V +++GGG+R + L G++RVV+G+ A ++ D+VK +++ Sbjct: 66 NAAAVDAIVKAFPGTIELGGGIRDMNAIDGWLSRGISRVVIGTAAFENPDLVKEAAQKYP 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+A+D R + V GW E S +S+ + E + G+ +L TD+ RDG Sbjct: 126 GQ-IVVAVDAR-----DGMVTTKGWAEQSEISVTDMAERFADAGVVALLYTDVGRDGLKK 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGT--GVRGVIVGRALLEGKFTVKE 237 G N S A + +SGG+ DI D+ L R T G+ GVI GRA+ +G +K Sbjct: 180 GCN-SEATLALAAATDIPVIASGGVKDIGDIELLARHTKDGIEGVICGRAIYDGSLDLKA 238 Query: 238 AIA 240 A+A Sbjct: 239 ALA 241 >UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=144 Tax=Bacteria RepID=HIS4_CORJK Length = 258 Score = 123 bits (308), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 88/247 (35%), Positives = 132/247 (53%), Gaps = 13/247 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D+ DG VRL QG G + YG P+ + GAE +HLVDL A Sbjct: 12 LLPAVDVADGQAVRLVQGAAGTETSYGA-PIEAALAWQNAGAEWIHLVDLDAAFGRGS-N 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L+K + ++V V++ GG+R +E + L G RV +G+ A++ + + R+G Sbjct: 70 FELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYG- 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + LD R + G ++ GW + G L +++E G+ ++ TD+SRDG L G Sbjct: 129 DKVAIGLDTR-EVDGEWRLRGRGWTSDGG-ELWEVLERLDSQGVSRLVVTDVSRDGMLNG 186 Query: 182 SNVSLYEEVCARY--PQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVK 236 N+ L EV A P VA SGGI +DD+ AL GV IVG+AL GKFT++ Sbjct: 187 PNIDLLREVAAATDAPVVA---SGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFTLE 243 Query: 237 EAIACWQ 243 EA+ Q Sbjct: 244 EALEAAQ 250 >UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_ANADF Length = 238 Score = 122 bits (307), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 76/230 (33%), Positives = 126/230 (54%), Gaps = 7/230 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL+ G VRL +GD+ + Y P + +++A GA +LH+VDL GAK Sbjct: 2 LVIPAIDLMGGEAVRLEKGDFATKTVYARHPAEKAEEFARAGATLLHVVDLDGAKAGWPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++ + + V++GGG+RS D+ +L GV VV+G+ AV+ +V+ +RF Sbjct: 62 NLDAVRAICEVPGIEVELGGGLRSLPDIEKVLALGVRYVVLGTAAVERLGLVEQACQRFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +D R N +V ++GW E +G++ + G+ V TD++RDG Sbjct: 122 GQ-VRAGIDAR-----NGEVKIAGWLEGTGLAAVDVARKVKGAGVGLVEYTDVARDGMFT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 G + + + A + +SGG+ +DDV A R G+ GVIVG+AL E Sbjct: 176 GVDAAGAARIQAE-AGIPVVASGGVASLDDVTACRAAGLAGVIVGKALYE 224 >UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=142 Tax=cellular organisms RepID=HIS4_METNO Length = 253 Score = 122 bits (305), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 84/248 (33%), Positives = 133/248 (53%), Gaps = 10/248 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL +G VRL QGD + + +DP + +A QG LH+VDL GA A Sbjct: 5 ILFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFAGAPM 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++A V +PVQ+GGG+R V L GV+RV++G+ AV+ V+ F Sbjct: 65 NAAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFVREAARLFP 124 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V ID + + +VAV GW + S V+ E+L + G+ ++ TDI+RDG L Sbjct: 125 GR-----IAVGIDAK-DGRVAVEGWAKTSTVTAEELGRRFEDAGVAALIYTDIARDGVLK 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKFTVKE 237 G N+ + + A+ + +SGG+ I+DV + + G I GRAL +G+ +E Sbjct: 179 GLNIPMTLAL-AQAVSIPVIASGGLASIEDVHRILEPDCALLAGAITGRALYDGRIDPRE 237 Query: 238 AIACWQNA 245 A+A + A Sbjct: 238 ALAAIRRA 245 >UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Methanomicrobiales RepID=HIS4_METMJ Length = 239 Score = 121 bits (304), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 83/238 (34%), Positives = 125/238 (52%), Gaps = 8/238 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D++DG V+L QG YG DP + +GA+ LH+V+L GA A++ Sbjct: 3 IYPAVDILDGRCVQLVQGRPEAATVYG-DPAAWAHRWLDEGADGLHVVNLDGAFGRARKN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ ++GGG+RS ED A L+AGV RV+V + AV+ +M++ E FG Sbjct: 62 ADLIRAFTRETETFTELGGGIRSVEDAAGWLDAGVDRVIVSTQAVREPEMIRTLAEEFGG 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++ +D R E V + GW+ +G L E + +G +L T++ +G G Sbjct: 122 ERVMAGIDARAGE-----VMIEGWERPAGSYL-SWAERFESLGAGSLLYTNVDVEGLQQG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 + E+ AR +V SGGI DVAALR G G ++G AL GK + EA+ Sbjct: 176 IAIEPVTELLARV-KVPVVVSGGISSPGDVAALRDAGAAGAVLGSALYAGKVRLPEAM 232 >UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodopirellula baltica RepID=HIS4_RHOBA Length = 253 Score = 120 bits (302), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 81/241 (33%), Positives = 123/241 (51%), Gaps = 10/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAK-DPAKR 60 I PA+DL G VRL QGDY +Q +G+DP+ + + GA+ LHLVDL A+ D Sbjct: 14 IWPAIDLRHGKPVRLRQGDYDQQTTFGDDPVEFAKRWQESGAKRLHLVDLDAARGDSPDA 73 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ ++ +P Q+GGGVR E + +LL GV R+VVGS A+K D +++ Sbjct: 74 NRDAVQRIIEATGLPCQMGGGVRDEITIESLLNVGVTRLVVGSRALKDPDWFVEMCDKYP 133 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP--VGLKHVLCTDISRDGT 178 LV +D R + +VA GW E S VS + + ++ TDI++DG Sbjct: 134 G-KLVAGIDAR-----DGKVATQGWLETSDVSAFEFATKLRSRTENIAAIVYTDIAKDGM 187 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 + G N E+ A + +SGG+ DD+ L + IVGR+L +G + E Sbjct: 188 MQGPNFEGLAEMAA-ASDIPLVASGGVTTYDDIKQLVEMKMPAAIVGRSLYDGVMELGEV 246 Query: 239 I 239 + Sbjct: 247 V 247 >UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillales RepID=HIS4_LACC3 Length = 238 Score = 119 bits (297), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 75/230 (32%), Positives = 124/230 (53%), Gaps = 14/230 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL++G VRL QGDY Q DPL + Q G LHLVDL GA+ A+R Sbjct: 3 LYPAIDLLNGKSVRLTQGDY-DQVSLTEDPLYQAQRLTDAGFAHLHLVDLDGAR--AQR- 58 Query: 62 IPLIKTLVAGV----NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 P+ +T++ + + +++GGG+R+ + L G+ R+++GS AV D+V+ Sbjct: 59 -PINRTVITRIREQTSAFIELGGGIRTLAAMEIYLTIGIDRLILGSAAVSDPDLVEQAIA 117 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 RFG++ + + +D R + VA +GW S + L+ G+ + TDI++DG Sbjct: 118 RFGSNRIAVGIDTRAGK-----VATNGWLTTSQQTANALLTAMQQRGVTTFIVTDIAKDG 172 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 + G N L ++ PQ +SGGI + D+ L+ G++ I+G+A Sbjct: 173 MMQGPNAQLLADLQQAMPQATIIASGGISLLADLHRLQTAGIQAAIIGKA 222 >UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41EB6 Length = 246 Score = 119 bits (297), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 137/244 (56%), Gaps = 8/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+D+ G V+L QG G ++ +P + + GAEV+H++DL GA + Sbjct: 9 LIMPAVDIRGGKCVQLVQGKPGSEQVVIENPEKVAKKWEDAGAEVVHVIDLDGALESV-T 67 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I IK ++ V+VP+Q+GGG+RS E LL + R+++G+ +K+ +++ +G Sbjct: 68 NIETIKKILNEVSVPIQLGGGIRSIEYAEELLNLDIDRLIIGTMGIKNPEIISKLSNEYG 127 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ ++++LD + + +V + GWQE S ++ + + +G +L T++ +G L Sbjct: 128 SERVMISLDSK-----DNKVVIKGWQEKIDKSASEISKEFQELGAGSILFTNVDVEGLLG 182 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G V ++ + SGG+ +DD+ L+ TG +GV++G AL + K +++A+ Sbjct: 183 GFYVDPVIDLVDSV-DIPVVYSGGVTSLDDLKQLQTTGAKGVVIGSALYKDKIKLEDALK 241 Query: 241 CWQN 244 +QN Sbjct: 242 -YQN 244 >UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Dictyoglomus RepID=HIS4_DICT6 Length = 242 Score = 119 bits (297), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 78/243 (32%), Positives = 130/243 (53%), Gaps = 14/243 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ VVR+ G K N+PL + + +GA+ LHL+DL A D Sbjct: 2 LIIPAIDIYKHKVVRMETGKKEKIVLEFNNPLDLAKYWEEKGAKALHLIDLQSAIDANDE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ +V V++PV+VGGG RS E + + GV RV+V S D + F ++ Sbjct: 62 SKSIVRDIVRSVSIPVEVGGGYRSREKIEEAISWGVWRVIVSSILGMELDYLLDLFSKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++ ++D + +V + GWQ+ + + + ++ V+ TDISRDGTL Sbjct: 121 ENKIIPSID-----WYDGKVGIKGWQD--FIEWRDIKRKIDLLKVREVIFTDISRDGTLK 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR----GTG-VRGVIVGRALLEGKFTV 235 G N+ + + + + +GGI I+DV ++ TG ++G+I+GRALLEGK Sbjct: 174 GVNLENIKNFLSLHDYDVW-IAGGISSIEDVIKIKDLSENTGRIKGIIIGRALLEGKINW 232 Query: 236 KEA 238 +EA Sbjct: 233 EEA 235 >UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Methanocaldococcus RepID=C9RH20_METVM Length = 237 Score = 116 bits (290), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 78/240 (32%), Positives = 132/240 (55%), Gaps = 10/240 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL D V+L QGD K+ DP+ + + GAE LH+VDL A Sbjct: 2 IVIPAVDLKDKKCVQLIQGDPTKKHLELEDPVNVAKKWVHDGAEYLHIVDLDAALGCG-N 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I+ +V VN+PV+VGGG+RS L++ GV ++VVG+ A+ + Sbjct: 61 NVDVIEKIVEEVNIPVEVGGGIRSLTIAKRLMDIGVDKIVVGTKAITDPTFLNELLSEIE 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETY-LPVGLKHVLCTDISRDGTL 179 + ++LA++ + QG +VA+ GW+E + ++ + Y VG +L T++ +G L Sbjct: 121 REKIILAVECK---QG--KVAIKGWKETINKNPIEIAKKYEKKVG--GILFTNVDVEGML 173 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 +G + E + + +V SGGI ++D+ L+ GV GVI+G AL +G +K+A+ Sbjct: 174 SGIKTDIIETL-VKNVRVPIIYSGGITTLEDIKKLKEIGVDGVIIGSALYKGIINLKDAL 232 >UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZ82_ACIFD Length = 246 Score = 112 bits (280), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 90/250 (36%), Positives = 134/250 (53%), Gaps = 18/250 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA-KR 60 ++ A+DL+DG VRL QG + R +G DP ++ GA H+VDL A+ P +R Sbjct: 3 LVVAVDLLDGEAVRLRQGRFDAPRRFG-DPRRYVEGALDAGARWFHVVDLDRARTPGDRR 61 Query: 61 QIPLIKTLVAGVN---VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 ++ L+A V V+VGGGVR+ D+A LLE G +RVV+G+ V+ + Sbjct: 62 NADMVGDLIALVREAGGSVEVGGGVRTARDIAELLETGASRVVLGTALVEET------LD 115 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 + LV ALD R ++G +V VS W+ + G L + G++ L TD+ RDG Sbjct: 116 ELDPEHLVAALDYRRGDEGALEVVVSAWERSGGRRLLEASARLFARGVRTQLLTDVGRDG 175 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD---VAALRGT--GVRGVIVGRALLEGK 232 +G ++ Y+ +C P V +SGG+ DD +AA+RG V G +VG ALL+G Sbjct: 176 MASGPDLGTYQGLCEVVP-VEVIASGGVASADDLAKLAAIRGARGAVWGAVVGTALLDGS 234 Query: 233 FTVKEAI-AC 241 EA+ AC Sbjct: 235 LGFDEALSAC 244 >UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Opitutaceae RepID=HIS4_OPITP Length = 243 Score = 111 bits (278), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 80/234 (34%), Positives = 122/234 (52%), Gaps = 13/234 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ G VRL QG ++ Y +P + A G+E +H+VDL GA + Sbjct: 3 IYPAIDIKGGRCVRLTQGRAEQETIYAQNPADVAMQFRAAGSEWVHVVDLDGAFAGEPQN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ +VA V + VQ GGG+R+ V L GV+RVV+G+ A +S+ V + FG Sbjct: 63 LAAVQAIVA-VGMKVQFGGGLRTRAAVERALALGVSRVVLGTRAAESESFVGELVQAFG- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D + N +VAV GW + +S L +G+ ++ TDI DG L G Sbjct: 121 DKIAVGIDAK-----NGKVAVKGWVATADLSTLVLARRMDTLGVATLIHTDIGTDGMLTG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-----RGTGVRGVIVGRALLE 230 N++ E +C+ +SGG+ DDV L R + GVIVG+AL E Sbjct: 176 PNLAAQEALCSAVKSRVI-ASGGVSRRDDVVNLAKLAQRHANLDGVIVGKALYE 228 >UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=cellular organisms RepID=HIS4_THEON Length = 229 Score = 109 bits (272), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 77/242 (31%), Positives = 124/242 (51%), Gaps = 16/242 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL+ G VRL++G K + YG DP+ + + + +H+VDL GA + Sbjct: 3 IYPAIDLMGGKAVRLYRGQKEKVKVYG-DPVE-IASRFTELVDKIHVVDLDGAFTGKPQN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++K ++ + VQVGGG RS E +A E G V++G+ A + ++ + F Sbjct: 61 LDVVKEIIEETGLKVQVGGGFRSYESIAKAYEIGAENVIIGTKAF-DLEFLEKITDNF-- 117 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + ++LD R ++AV GW E S + + + E L + + T I RDGTL G Sbjct: 118 DGITVSLDAR-----GGKIAVKGWLEESSLKVGEAYEM-LREYVDRFIYTSIERDGTLTG 171 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 E + + F +GG+ +DDV LR G G IVG+AL E + ++KE + Sbjct: 172 -----IESIERFWKDEEFIYAGGVSSVDDVLKLRRVGFSGAIVGKALYESEVSLKELLEV 226 Query: 242 WQ 243 + Sbjct: 227 LE 228 >UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=HIS42_PHOLL Length = 258 Score = 107 bits (268), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/252 (31%), Positives = 131/252 (51%), Gaps = 14/252 (5%) Query: 2 IIPALDLIDG------TVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 I P++D++DG + +RL +G+ R P + GA+ +H+VDL A Sbjct: 9 IFPSVDIVDGIAMTSNSAIRLTRGESSTLRRPLGTPAEVALAWQNAGAKWIHVVDLDAAS 68 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 LI ++A V++ VQV GG+R E + +L G RV +G+ A+++ D Sbjct: 69 GRGSNS-HLIADVLAAVDINVQVCGGIRDETILRKVLATGCQRVNLGTAALENPDWCAQA 127 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +G D + +ALDV+ +G Q+A GW + G +L L+E G + + TD+ R Sbjct: 128 IAEYG-DKIAIALDVKSTSEG-YQLATHGWNVSKG-NLWDLLERLDKQGCQRYVVTDVER 184 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGK 232 G ++ N +L +EVCA+ + GG+ +DD+ A L GV G I+G+AL GK Sbjct: 185 GGMMSSPNFTLLQEVCAKTSSPVI-AGGGVSSLDDLRALADLSTIGVEGAILGQALHIGK 243 Query: 233 FTVKEAIACWQN 244 +++A+A Q+ Sbjct: 244 VPLEDALAATQS 255 >UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_SYMTH Length = 249 Score = 107 bits (266), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 85/245 (34%), Positives = 128/245 (52%), Gaps = 14/245 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL DG VVRL QG + YG DP+ +A GA +H+VDL GA + Sbjct: 5 LYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQN 64 Query: 62 IPLIKTLVAGVN-----VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 ++ +V + V VQ+GGG+R+ E + A L GV+R ++G++A++ D+ Sbjct: 65 AAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSALEG-DVAARAV 123 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 RFG D + +++D R VA GW E + V L VG++ V+ TDI+ D Sbjct: 124 ARFGPDRVAVSIDAR-----GGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATD 178 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTV 235 G L G N + E + V +SGGI ++D+ L GV G I+GRAL G + Sbjct: 179 GMLTGPNFAELEMMGRTGLDVI--ASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDL 236 Query: 236 KEAIA 240 EA++ Sbjct: 237 AEALS 241 >UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 n=15 Tax=Rhodobacterales RepID=HIS41_SILST Length = 247 Score = 104 bits (259), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 76/246 (30%), Positives = 123/246 (50%), Gaps = 13/246 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI P ++L+DG V L +G+ + DP+ + +A GAE +HL D + + Sbjct: 2 MIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFNALQGDSSN 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q L++ L+ +P+Q+GGG+RS E +E GV RVV+G+ A V ++ Sbjct: 62 Q-DLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAE-LAKYY 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +VLA+DV QG QV GW+++ + E V+ + +L TDI D + Sbjct: 120 PDQVVLAVDVW---QG--QVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVTDIDSDMSDL 174 Query: 181 GSNVSLYEEVC--ARYPQVAFQSSGGIGDIDDVAALRG-TGVRGVIVGRALLEGKFTVKE 237 + + L + A P +A SG + DD++ L+ + G +VGRAL T++E Sbjct: 175 DAQLGLISGLAEQAHSPVIA---SGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEE 231 Query: 238 AIACWQ 243 A+ Q Sbjct: 232 AMETAQ 237 >UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Archaeoglobaceae RepID=HIS4_ARCFU Length = 238 Score = 103 bits (257), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 77/240 (32%), Positives = 122/240 (50%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL DG VVRL QG + +P+ + + GA+VLH++DL+GA R Sbjct: 4 VIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRLRH 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + VQVGGG+R L E GV RV+ G+ AV+ + ++ + +++ Sbjct: 64 EEIIAEIAK--MAEVQVGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKWKG 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V A+D + +VAV GW+E ++ QL E Y + + L T+I +G ++G Sbjct: 122 RVMV-AIDSK-----KGRVAVKGWKEVVELTPVQLAELYDDLDVSF-LYTNIDVEGLVSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 EEV + +GGI I+D+ + G GV++G AL K +EAI Sbjct: 175 IERERIEEVVKSLRNPVY-VAGGISSIEDIRFAKRVGAAGVVIGSALYTKKLKFEEAIKV 233 >UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=HIS4_THENN Length = 248 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 81/252 (32%), Positives = 130/252 (51%), Gaps = 17/252 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL VVR+ +G Y DP+ ++ +G ++H+VDL+ A + + Sbjct: 2 LVIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEESDE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +P+++ L + + +Q+GGG+R E LL G R +V S ++ +K E G Sbjct: 62 NLPVLEKLSSYAD-HIQIGGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKLKE-IG 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V +LD R +G +VA GW + + LV GL+ ++ T+I +DGTL Sbjct: 120 VNP-VFSLDTR---EG--KVAFKGWLDEKDIDPVFLVNRLKEFGLEEIVHTEIEKDGTLK 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AAL----RGTG-VRGVIVGRALLEGKFT 234 + SL E + A V ++GGI + AL R G ++GVIVGRA LEG T Sbjct: 174 EHDFSLTERI-ALETGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGRAFLEGTLT 232 Query: 235 VK--EAIACWQN 244 V+ + AC +N Sbjct: 233 VEVMKRYACQEN 244 >UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=1 Tax=Silicibacter lacuscaerulensis ITI-1157 RepID=D0CY30_9RHOB Length = 282 Score = 99.4 bits (246), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 76/247 (30%), Positives = 119/247 (48%), Gaps = 13/247 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + P ++L +G V L +G + + DP+ Q +AA GAE +HL D A + Sbjct: 38 VYPTMELQNGRCVTLDKGRLDEPMIWHVDPVETAQGWAAAGAEWMHLTDF-DAIEGRDTN 96 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ ++ +PVQ+ GG RS E V ++ G R+V+G+ A + + K + Sbjct: 97 SALVEQIIRSAELPVQLAGGFRSREQVERWIDKGAGRIVIGTLAARDPHLFKE-LAKLYP 155 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D +VLA+DV QG V GW+ S S E +E + L +L TDI D Sbjct: 156 DQIVLAVDV---WQG--YVMTDGWRTQSAFSPEAFIEAFADAPLAAILVTDIDSDMVDVE 210 Query: 182 SNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEA 238 + + L + A R P +A SG + DD++ L + GV+VGRAL + EA Sbjct: 211 AQLGLISGLAAHSRTPVIA---SGVVRSSDDISRLAYIPNISGVLVGRALFRKTVDLSEA 267 Query: 239 IACWQNA 245 +A + A Sbjct: 268 LAVARTA 274 >UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8V9_IGNH4 Length = 235 Score = 97.4 bits (241), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 70/241 (29%), Positives = 125/241 (51%), Gaps = 11/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + P++D+ +G V+ +G G D G DP+ + +A +GA+ LH+VDL GA+ Sbjct: 3 VFPSIDVSEGRAVKRVRGVKGTGLDLG-DPVKWAEFWALEGAKGLHVVDLDGAEAGKPIN 61 Query: 62 IPLIKTLVAGVN---VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + +I ++ + VQV GG+R E + +A V+GS A K + ++ E Sbjct: 62 VEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPKADA--FVIGSRAHKDPEFLEVASEA 119 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 GAD +++A+D++ +V+V GW+E V L++ +E + + L T + +GT Sbjct: 120 VGADKVIVAIDLK-----GGKVSVEGWKEEIPVGLKEALEKFKGRSFRGFLYTYVDTEGT 174 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 + G +VS + + YP + +GG+G + V L G V++G AL GK +K+ Sbjct: 175 MEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDL 234 Query: 239 I 239 + Sbjct: 235 V 235 >UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=60 Tax=Staphylococcus RepID=HIS4_STAAB Length = 234 Score = 95.9 bits (237), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/231 (26%), Positives = 111/231 (48%), Gaps = 8/231 (3%) Query: 4 PALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAA-QGAEVLHLVDLTGAKDPAKRQI 62 PA+DLI T VRL +G Y + + Y+ + +H+VDL GAK R+ Sbjct: 6 PAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAREF 65 Query: 63 PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGAD 122 IK+L ++VGGG+R++ + AG+ +VG+ ++ D +K F Sbjct: 66 DYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFPG- 124 Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 + +D G + + V+GW+E++ ++L V+ + L ++ T I++DG ++G Sbjct: 125 ----RIYFSVDAYG-EDIKVNGWEEDTELNLFSFVKQLSDIPLGGIIYTHIAKDGKMSGP 179 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 N L ++ + + +SGGI D+ L V I+G+A + F Sbjct: 180 NFELTGQLV-KATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASF 229 >UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW6_9FIRM Length = 252 Score = 92.4 bits (228), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 68/237 (28%), Positives = 122/237 (51%), Gaps = 5/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ RD G DP+ Y + A+ L +D+T + D Sbjct: 6 IIPCLDVKDGRVVK--GTNFVGLRDAG-DPVELAARYDEERADELVFLDITASSDNRGTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + + + V +P VGGG+R+ ED+ +L+AG + + + AVK+ ++K E+FG Sbjct: 63 VNVARDCASKVFIPFTVGGGIRTVEDMRRMLKAGADKTSLNTAAVKNPGLLKEGAEKFGR 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +VLA+D R +V V+G + +G+ + V+ + +G +L T + DGT G Sbjct: 123 QCMVLAVDARRAGNHRWEVYVNGGRTPTGLDCLEWVKKAVALGAGEILLTSMDADGTKDG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE-GKFTVKE 237 ++ L V + V +SGG G ++ + G ++ ++ G+FTV++ Sbjct: 183 YDIELTRAV-SDAVNVPVIASGGAGKLEHFYDVLTLGHADAVLAASVFHYGQFTVRQ 238 >UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TG14_METVO Length = 148 Score = 92.0 bits (227), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 48/137 (35%), Positives = 85/137 (62%), Gaps = 6/137 (4%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 + GAE+LHLVDL GA D + +P++K ++ VPVQ+GGG+R+ EDV L+ G+ Sbjct: 13 WVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIEDVEELVNLGIN 72 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 RV++G+ AV++ D V+ ++ G++ +++ALD + + +V + GW+E + + Q+ Sbjct: 73 RVIIGTVAVQNPDFVEKLAKKVGSEKIMVALDAK-----DGKVVIKGWKEKTEYTPVQM- 126 Query: 158 ETYLPVGLKHVLCTDIS 174 YL ++ V C +S Sbjct: 127 GKYLRKKVQVVYCLPMS 143 >UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW5_HODCD Length = 241 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/240 (30%), Positives = 114/240 (47%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + ++D+ +G VRL +G R Y + PL ++ + Q +++H+VDL GA + + Sbjct: 3 FLASIDVKNGECVRLCRGQMADCRVYASSPLEAVRKFNLQCCDLVHIVDLDGAVCGSPQN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I + VQVGGGVR+ D LE G ++VV+G++A+ + V + Sbjct: 63 WRSILEAARQLKGCVQVGGGVRTLADAKLYLEGGASKVVLGTSAIADMEFVCHVSWLYPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 V +D G + VA GW S V +QLV + ++ TDI+RDGTL G Sbjct: 123 RVC-----VGVDTFG-ELVATDGWTAVSCVRCDQLVPKLEAARVSCLIWTDINRDGTLQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIG---DIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 N + V A V SGG+ D+ + L + GVI G+AL E T + A Sbjct: 177 VNFDALDRVLAA-SAVPVIVSGGVATALDLIKLHNLYADKLAGVICGKALYERTLTARFA 235 >UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hisF n=28 Tax=Bacteria RepID=HIS6_EXISA Length = 255 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 68/237 (28%), Positives = 132/237 (55%), Gaps = 8/237 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ ++ + RD G DP+ + Y GA+ L +D+T + + + Sbjct: 6 IIPCLDVKEGRVVK--GIEFVQLRDIG-DPVEIAKYYDESGADELVFLDITASTERRQTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + V +P+ VGGG+RS ED+++LL+AG +V + + AV+S +++ +RFG+ Sbjct: 63 LDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+DV+ + G V G ++ + + + + +G +L T +++DG +G Sbjct: 123 QCIVVAIDVKFKD-GEYYVYTYGGKQKTDLLAVEWAKQVAALGAGELLVTSMNQDGKQSG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTVKE 237 ++S+ E++ + +SGG G+ + V AL V ++ L + K TV+E Sbjct: 182 YDLSILEQL-REVVDIPIIASGGAGNAEHVVEALE--KVDAALLASILHDRKTTVEE 235 >UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermotogaceae RepID=HIS4_THEP1 Length = 241 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 73/245 (29%), Positives = 126/245 (51%), Gaps = 21/245 (8%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+DL G V R+ +G Y DP ++ +G ++H+VDL+ A + + Sbjct: 2 LVVPAIDLFRGKVARMVKGKKENTIFYEKDPAELVKKLIEEGFTLIHVVDLSKAIENSVE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 P+++ L + +Q+GGG+RS + L + G R +V S ++ +K + + Sbjct: 62 NFPVLERL-SEFAEHIQIGGGIRSFDYAERLRKLGYKRQIVSSKVLEDPSFLK-FLKEID 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGW---QENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 + V +LD R G K VA GW +E +SL + ++ Y GL+ ++ T+I +DG Sbjct: 120 VEP-VFSLDTR----GGK-VAFKGWLAEEEIDPISLLKRLKEY---GLEEIVHTEIEKDG 170 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL----RGTG--VRGVIVGRALLEG 231 TL + SL ++ +V ++GGI + + R T ++GVIVGRA LEG Sbjct: 171 TLQEHDFSLTRKIAIE-AEVNVFAAGGISSENSLKTAQRVHRETNGLLKGVIVGRAFLEG 229 Query: 232 KFTVK 236 TV+ Sbjct: 230 ILTVE 234 >UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V5Z6_9AQUI Length = 119 Score = 91.3 bits (225), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 43/111 (38%), Positives = 74/111 (66%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ +G VRL++GD + YG++P+ + + +GA+ LH+VDL GA + + Sbjct: 6 FIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHIVDLDGAFEGIPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM 111 +++ +V VNVP++ GGG+R+ E V ++E GV RVV+GS A + +++ Sbjct: 66 NYKIVEQIVKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDKEL 116 >UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Methanopyrus kandleri RepID=HIS4_METKA Length = 242 Score = 90.1 bits (222), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 70/234 (29%), Positives = 119/234 (50%), Gaps = 12/234 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IP++D+++G V+L +GD ++ +DP+ ++ + +H+VD+ A+ Sbjct: 4 VVIPSVDVVEGKCVQLVEGDPERRTFESDDPVETAHQWS-EFFPWIHVVDVDAARGEGDN 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE--- 117 +I + V+ VQVGGG+RS E L+E G R++VG+ A +D + Sbjct: 63 S-DIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDDFSKIVDVCH 121 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 G + V ALDV N +V VSGW+E++GV+LE +E + V + L T + +G Sbjct: 122 DHGIEVFV-ALDV----NENHEVLVSGWKEDAGVTLEDAIERFNEVADGY-LTTAVHVEG 175 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 G + + E+ + +GGI I DV + G GV++G AL G Sbjct: 176 KEMGIDEKVVEKSTGA-TDLPVLYAGGIASIKDVKRAKEAGAYGVVIGTALYHG 228 >UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hisF n=10 Tax=Bacteria RepID=HIS6_SULSY Length = 252 Score = 89.4 bits (220), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 111/209 (53%), Gaps = 8/209 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ D G DP+ Y +GA+ L +D+T + + Sbjct: 6 IIPCLDVDKGRVVK--GVNFVNLIDAG-DPVEIASVYDKEGADELVFLDITASSEDRNII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++K V +P+ VGGGVRS ED+ LLE G +V + + AVK+ +V+ RFG+ Sbjct: 63 LDVVKKTAETVFMPLTVGGGVRSLEDIRKLLENGADKVSINTAAVKNPSLVENAAIRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+D + + +V + G + +G+ + + +G +L T + +DGT +G Sbjct: 123 STIVVAIDAKKVGENKWEVYIHGGRTPTGIDAIEWAKAVESLGAGEILLTSMDKDGTKSG 182 Query: 182 SNVSLYEEV--CARYPQVAFQSSGGIGDI 208 ++ L + V + P +A SGG G++ Sbjct: 183 YDIELTKAVSEAVKIPVIA---SGGAGNV 208 >UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E352 Length = 229 Score = 89.0 bits (219), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 66/243 (27%), Positives = 116/243 (47%), Gaps = 18/243 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G V L G K +G DP+ Q++++ + LH+VDL GA Sbjct: 4 IYPAIDIYNGEAVSLENGKIEKIESFG-DPVKFAQEFSSISGK-LHIVDLNGAFTGNPAN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LIK + V +Q GGG R+ E + A G+ +++G TA + +++ E+ Sbjct: 62 TNLIKNIRKNVKSFMQAGGGYRTMESIEAGYSLGIDSIIIG-TASLDKKILEEVSEK--H 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D N + +GW + + +S + + + T I+ DGT Sbjct: 119 KNITISIDAY-----NGYIKYNGWADGTEISYRDFY-SMVKGRANRFIFTAINSDGT--- 169 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++S E+ + + F +GG+ IDD+ L G G I+G+AL G ++E + C Sbjct: 170 GHISRIEKF---WDEGYFMYAGGVNSIDDLKKLENMGFNGAIIGKALYNGNIKIEE-LKC 225 Query: 242 WQN 244 QN Sbjct: 226 LQN 228 >UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hisF n=157 Tax=root RepID=HIS6_HELMI Length = 261 Score = 89.0 bits (219), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 122/232 (52%), Gaps = 17/232 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ RD G DP+ Y +GA+ + +D+T + D Sbjct: 6 IIPCLDVHGGRVVK--GTNFVNLRDAG-DPVELAAVYDKEGADEVVFLDITASSDGRAIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ V +P VGGG+RS ED+ +L+AG ++ + ++AV++ ++ +FG+ Sbjct: 63 LDVVRRTAEEVFIPFTVGGGLRSVEDIREMLKAGADKISLNTSAVQTPKLISDGAWKFGS 122 Query: 122 DALVLALDV--RIDEQGNK----QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +V+A+D R D +GN +V G ++ +G+ + + +G +L T + + Sbjct: 123 QCIVVAIDARRRRDAEGNPVEGWEVYTHGGRKPTGIDVLEWARRVEELGAGEILLTSMDK 182 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 DGT G ++ L V + + +SGG+G++D + V G+ VG+A Sbjct: 183 DGTKDGYDIPLTRAV-SEAVTIPVIASGGVGNLDHI-------VEGLTVGKA 226 >UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hisF n=420 Tax=cellular organisms RepID=HIS6_BRUMB Length = 261 Score = 87.0 bits (214), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 73/244 (29%), Positives = 123/244 (50%), Gaps = 13/244 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP LD+ DG VV+ ++ D G DP+ + Y A GA+ L +D+T + D + Sbjct: 7 VIPCLDVKDGRVVK--GVNFVDLIDAG-DPVEAARAYDAAGADELCFLDITASSDNRETI 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ +P+ VGGGVR D+ LL AG +V + + AVK+ + V ++FG Sbjct: 64 FDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFGN 123 Query: 122 DALVLALDVR----IDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+A+D + E + ++ G ++ +G+ + + + +G +L T + RDG Sbjct: 124 QCIVVAIDAKKVSGAGENDHWEIFTHGGRQPTGIDAVEFAQKVVDLGAGEILLTSMDRDG 183 Query: 178 TLAGSNVSLYEEVC--ARYPQVAFQSSGGIGDIDD-VAALRGTGVRGVIVGRALLEGKFT 234 T AG +V+L V R P +A SGG+G +D VA +R V+ G +T Sbjct: 184 TKAGYDVALTRAVADSVRAPVIA---SGGVGTLDHLVAGIRDGHATAVLAASIFHFGTYT 240 Query: 235 VKEA 238 + EA Sbjct: 241 IGEA 244 >UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=C7P985_METFA Length = 272 Score = 86.7 bits (213), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 117/224 (52%), Gaps = 23/224 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ + + RD G DP+ Q Y +GA+ L +D+T + + Sbjct: 6 IIPCLDIKDGRVVKGTK--FLNLRDAG-DPVELAQLYDDEGADELVFLDITASAEKRDII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ V +P+ VGGG++S ED +L AG ++ + + AVK+ +++K E FG+ Sbjct: 63 IDVVERTAEKVFIPLTVGGGIKSIEDFRKILRAGADKISINTAAVKNPNLIKEASEIFGS 122 Query: 122 DALVLALDV-----------RIDEQGNK--------QVAVSGWQENSGVSLEQLVETYLP 162 +V+A+D +ID+ K +V + G ++ +G+ + + Sbjct: 123 QCVVVAIDAKRHYINEDEIDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKVEE 182 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIG 206 +G +L T I +DGT +G ++ L E+ ++ ++ +SGG G Sbjct: 183 LGAGEILLTSIDKDGTKSGYDLILTREI-SKSVKLPVIASGGCG 225 >UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hisF n=55 Tax=cellular organisms RepID=HIS6_THEEB Length = 281 Score = 85.9 bits (211), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 73/236 (30%), Positives = 114/236 (48%), Gaps = 22/236 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ G VV+ ++ RD G DP+ Q Y A GA+ L +D+T + Sbjct: 7 ILPCLDVKAGRVVK--GVNFVNLRDAG-DPVELAQAYNAAGADELVFLDITATHEERNIL 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V +P+ VGGG++S + LL AG +V + S AV+ D+V +RFGA Sbjct: 64 IDVVYRTADQVFIPLTVGGGIQSLTMIKDLLRAGADKVSLNSAAVRQPDLVNQASDRFGA 123 Query: 122 DALVLALDVRID-----EQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +V+A+D R + +Q QV V G +E +G+ G +L T + D Sbjct: 124 QCIVVAIDARREPDCAPDQPRWQVYVRGGREATGLDAVAWAVEMAKRGAGELLVTSMDAD 183 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 GT AG ++ L + R ++ +SGG G + + A AL+EGK Sbjct: 184 GTQAGYDLELTRAIAERV-EIPVIASGGAGTCEHIRA-------------ALVEGK 225 >UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_MYXXD Length = 238 Score = 85.5 bits (210), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 66/231 (28%), Positives = 111/231 (48%), Gaps = 7/231 (3%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQI 62 IPA+DL +G V+L G Y ++ +PL L+ + G H+VDL A Sbjct: 4 IPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSNAD 63 Query: 63 PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGAD 122 + + + VGGGVR + V +L G VVVG+ A++ + RF Sbjct: 64 AIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRF-PG 122 Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 +V+A DV+ ++V GW S + +++ + P+ L +L T + ++G L+G Sbjct: 123 RVVVAADVK-----GREVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKEGQLSGV 177 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 ++ L EV A + +SGG+ ++D+ AL G G ++G AL G+ Sbjct: 178 DLPLMREV-ASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRL 227 >UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hisF n=76 Tax=Bacteria RepID=HIS6_MYCBP Length = 267 Score = 85.5 bits (210), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 108/214 (50%), Gaps = 10/214 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP LD+ DG VV+ ++ RD G DP+ Y A+GA+ L +D+T + Sbjct: 17 VIPCLDVDDGRVVK--GVNFENLRDAG-DPVELAAVYDAEGADELTFLDVTASSSGRATM 73 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ V +P+ VGGGVR+ DV +LL AG +V V + A+ D++ +FG+ Sbjct: 74 LEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFGS 133 Query: 122 DALVLALDVRIDEQGNK------QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +VL++D R G+ +V G + +G+ Q +G+ +L + Sbjct: 134 QCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDA 193 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDID 209 DGT AG +++L V A V +SGG G ++ Sbjct: 194 DGTKAGFDLALLRAVRAAV-TVPVIASGGAGAVE 226 >UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase subunit n=3 Tax=Bacteria RepID=Q2LTH2_SYNAS Length = 254 Score = 85.5 bits (210), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 113/212 (53%), Gaps = 8/212 (3%) Query: 2 IIPALDLIDGTVVR-LHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 I+P LD+ +G VV+ +H + + +D G DP+ Y A+GA+ L ++D+ + K Sbjct: 6 IMPCLDMKEGRVVKGIH---FVELKDAG-DPVENAAFYQAEGADELAMLDIAATLENRKT 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ + + A + +P+ VGGG+ + ED+ +L+AG A++ + S AVK+ +V ++FG Sbjct: 62 RLEWVNKVSAVLTIPLTVGGGISTLEDIELVLQAGAAKISMNSAAVKNPSLVSEAAKKFG 121 Query: 121 ADALVLALDVRIDEQ--GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 ++ + +A+D R + Q ++ VSG T +G +L T + DGT Sbjct: 122 SEKITVAIDARRNSQMPSGFELVVSGGTLPVARDAVAWARTCQELGAGVILPTSMDGDGT 181 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 AG ++ Y + A + +SGG G ++D Sbjct: 182 RAGYDIE-YTKAIADAVDLPVVASGGAGKLED 212 >UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Acidobacteria RepID=Q1IKB1_ACIBL Length = 228 Score = 84.7 bits (208), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 78/243 (32%), Positives = 121/243 (49%), Gaps = 25/243 (10%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IP++DL+ G +V+L QG+ K+ D + +A G ++ L+DL D AKR Sbjct: 1 MLIPSIDLMGGKIVQLVQGE--KKAFETTDFDAWCERFA--GFPMVQLIDL----DAAKR 52 Query: 61 Q---IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQ----DMVK 113 Q LI +V + +P QVGGGVR + LL G RV+VGS+ ++ D + Sbjct: 53 QGDNRELIANIV--LRLPCQVGGGVRDADVAERLLAIGAKRVIVGSSYIRDGRVDVDFAR 110 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 G ER G D ++ A+D R VAV GWQE+ ++ +++ P + L T + Sbjct: 111 GLAERCGTDRVIAAIDSR-----EGFVAVRGWQESVPITAGEMIAALTPY-VGGFLYTHV 164 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 +G L G + + + ++GGI +++ L G GV V VG A+ GK Sbjct: 165 DTEGLLVGFPTDIARRL-RTLTEKQLIAAGGIRSQEEIDELDGIGVDAV-VGMAIYTGKL 222 Query: 234 TVK 236 VK Sbjct: 223 VVK 225 >UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Picrophilus torridus RepID=Q6KZD4_PICTO Length = 222 Score = 84.3 bits (207), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 70/248 (28%), Positives = 116/248 (46%), Gaps = 38/248 (15%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLP---RLQDYAAQGAEVLHLVDLTGAKDPA 58 + PA+D+ +G V L G + + YG DP+ R Q+Y + LH++DL GA + Sbjct: 4 VYPAIDIYNGRAVFLENGRLERIKVYG-DPVYYALRFQEYF----DFLHVIDLNGAIENK 58 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 ++ +IK ++ V VQVGGG+R+ DV + + G ++G+ D Sbjct: 59 RKNRDVIKNIIKEVKAKVQVGGGLRTLNDVIDVYDFGAYSAIIGTNIDIEVDK------- 111 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGW---QENSGVSLEQLVETYLPVGLKHVLCTDISR 175 + L++DV D +VA GW +N VS ++++ + T+I Sbjct: 112 ----NVTLSIDVYKD-----RVANRGWLNITDNDPVSFYKMLKN----RFSRFIYTNIGS 158 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGT +N + E+ + F +GG+ I+DV G G+I+GRAL E + Sbjct: 159 DGT---NNSGIPEKF---WDNEYFIYAGGVSGINDVKKALKNGFSGIIIGRALYENRIDP 212 Query: 236 KEAIACWQ 243 E + C Q Sbjct: 213 GE-LKCLQ 219 >UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01ZU7_SOLUE Length = 227 Score = 82.8 bits (203), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 65/237 (27%), Positives = 117/237 (49%), Gaps = 15/237 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI+P +DL+DG VV+L QG ++ G+ P L+ +A G + ++DL A Sbjct: 1 MIVPCIDLMDGKVVQLIQGR--EKALEGDSPDEMLRRFA--GFPEIQVIDLDAALGKGSN 56 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L+K L + +VGGGVR+ + LL G RV+VG++A + + E Sbjct: 57 D-TLVKMLAS--KAVCRVGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLD 113 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ALD + ++ V GWQE + + E+++ + P LCT + ++G + Sbjct: 114 PATTIVALDSK-----GGRIVVKGWQEATEFTAEEVLHSLEPY-CSGFLCTYVDKEGMMQ 167 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G+++ + + A ++GGI ++D+ AL + VG A+ G+ ++E Sbjct: 168 GTDLDWFARLRAATAH-EITAAGGITTLEDIKALLAMNIH-TAVGMAIYTGRLDLEE 222 >UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase n=2 Tax=Rothia mucilaginosa RepID=D2NNQ2_9MICC Length = 262 Score = 82.8 bits (203), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 78/256 (30%), Positives = 123/256 (48%), Gaps = 25/256 (9%) Query: 2 IIPALDLIDGTVVRLHQGDY--GKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK 59 ++PA+D+ +G VR G G+QR DP+ + GA +HLVDL A Sbjct: 8 LLPAVDISEGYAVRPVGGTLSGGEQR---LDPVEAALTWVKAGARWIHLVDLDLAFGRGT 64 Query: 60 RQIPLIKTLVA----------GVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQ 109 L + + A V +QV GGVR+ E + L RV V S A+ Sbjct: 65 NTEVLAEVVAAVRAENARMTGSAPVRIQVSGGVRNPESLERALSLNPDRVNVTSAALADS 124 Query: 110 DMVKGWFERFG-ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHV 168 ++G R+ +D L L LD R + V V+ + SG + + + G++ Sbjct: 125 SWLEGTLARYADSDLLALGLDARYTPE-RGWVTVARGTDWSGPGVAEALAWLEGAGVRRY 183 Query: 169 LCTDISRDGTLAGSNVSLYEEVCARY--PQVAFQSSGGIGDIDDVAALRG---TGVRGVI 223 + TD+S+DG+LAG L + V A+ P VA SGG+ + D+ LR +G+ GV+ Sbjct: 184 IVTDVSKDGSLAGPGAELLDVVLAQTDRPVVA---SGGVASLADLVKLRSMVPSGLEGVV 240 Query: 224 VGRALLEGKFTVKEAI 239 +G+AL G F+ ++A+ Sbjct: 241 LGKALYVGNFSFEQAL 256 >UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hisF n=67 Tax=Bacteria RepID=HIS6_SYNY3 Length = 261 Score = 82.0 bits (201), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/213 (30%), Positives = 105/213 (49%), Gaps = 7/213 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ G VV+ ++ +D G DP+ + Y GA+ L +D+T + Sbjct: 7 ILPCLDVNAGRVVK--GINFVDLQDAG-DPVELARAYNEAGADELVFLDITATHEQRDTI 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V +P+ VGGG+ + E + LL AG +V V S+AV+ D + +RFG Sbjct: 64 IDVVYRTAEEVFIPLTVGGGISTLEHIKNLLRAGADKVSVNSSAVRDPDFISRASDRFGR 123 Query: 122 DALVLALDVRIDEQGNK---QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 +V+A+D R + V V G +EN+G+ E G +L T + DGT Sbjct: 124 QCIVVAIDARRRLDADNPGWDVYVRGGRENTGLDAIAWAEEVAKRGAGELLVTSMDGDGT 183 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 AG +++L + R ++ +SGG G+ V Sbjct: 184 QAGYDLALTAAIAERV-EIPVIASGGAGNCQHV 215 >UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hisF n=354 Tax=cellular organisms RepID=HIS6_METBU Length = 273 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/228 (28%), Positives = 113/228 (49%), Gaps = 27/228 (11%) Query: 2 IIPALDLI----DGTVVR-LHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 IIP LD+ GTVV+ + D K DP+ + Y QGA+ L +D+T + + Sbjct: 6 IIPCLDVTLDASGGTVVKGVEFVDLKK----AGDPVDLAKRYNEQGADELVFLDITASHE 61 Query: 57 PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 I +I+ V +P+ VGGG+ S EDV +L AG +V V + AVK+ + ++ Sbjct: 62 GRSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREAS 121 Query: 117 ERFGADALVLALDVR--IDEQGNK---------------QVAVSGWQENSGVSLEQLVET 159 FG+ +V A+D + +D + N+ +V + G +E +G+ Q + Sbjct: 122 NIFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIYGGREPTGLDTVQWAKK 181 Query: 160 YLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGD 207 +G +L T ++RDGT G ++ + +++ + +SGG+G+ Sbjct: 182 VEELGSGEILLTSMNRDGTYDGFDIPITKKLSEEL-DIPIIASGGVGN 228 >UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B9F8_THEAS Length = 253 Score = 80.9 bits (198), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 61/206 (29%), Positives = 105/206 (50%), Gaps = 4/206 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L+ G+ RL +G + DP+ + AQGAE + LVD+ ++ Sbjct: 6 IIPQF-LLKGS--RLVKGTSFRDHVDVGDPVSQAMIQDAQGAEEIVLVDVDATREGRLVD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI +V +P+ VGGGV + +D + L AG +V+V + AV + M++ ERFGA Sbjct: 63 TSLISRMVERCRLPIAVGGGVGNVDDASRLFVAGADKVIVNTAAVLNPSMIRPLAERFGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V++LD++ + + V +E + L+E G + T + R+GTL+G Sbjct: 123 QSVVVSLDLKRNSKRGWVPVVRSGEEEVDLDFVYLLEALEANGAGEFIVTSVDREGTLSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGD 207 ++ + +V +V +SGG G+ Sbjct: 183 FDLDML-KVVREVVKVPLIASGGAGN 207 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 80.1 bits (196), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 119/242 (49%), Gaps = 20/242 (8%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IP++DL+DG V+L QGD ++ ++ L++++ G + ++DL A Sbjct: 1 MLIPSIDLLDGKAVQLQQGDASRKIVEKDNLFELLEEFSLFGE--VAIIDLNAALGKGDN 58 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + LIK L+ +VGGG+R+ E L +G ++++G++ +D VK + Sbjct: 59 K-ALIKQLIK--KFSCRVGGGIRNYETAREYLSSGAKKIILGTSC--REDFVK----KLP 109 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 L+ A+D + D+ GWQ +S + +++ L L T + ++G + Sbjct: 110 RSQLIFAIDAKGDDW-----VTHGWQSSSDNKVAAMIDE-LQDNCSEFLYTQVEKEGMMQ 163 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI- 239 G + E+V + ++ +GGI D+DD+ + G + G ++ GK + EA+ Sbjct: 164 GIDRERIEQVI-KQSKIQVTVAGGITDLDDIKFINKLGANSQL-GMSIYTGKLKLDEAVM 221 Query: 240 AC 241 AC Sbjct: 222 AC 223 >UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3E3_9BURK Length = 251 Score = 78.6 bits (192), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/247 (25%), Positives = 113/247 (45%), Gaps = 15/247 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDL-----TGAKD 56 IIP++ + DG V + GD + DPL + +A GA+ LH+V L T Sbjct: 3 IIPSIYIQDGKCVHVSYGDKTSSSPFEIDPLDLAKKWADLGADRLHIVQLGLNASTQNAT 62 Query: 57 PAKRQIPLIKTLVAGVN--VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + ++ L+ V+ +P+Q+ GG+++ + + L+ G VVVGS VK + Sbjct: 63 SLSKNNEVLSKLIEEVSHYLPLQIAGGIKTMASIESYLDMGFDFVVVGSAGVKDPHFMND 122 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 F ++L LD R + +V W + + + + G+ ++ TD+ Sbjct: 123 ACSAFNG-QVILGLDAR-----DGKVVTDSWSKVTKFDAVTIAQRLTDEGIDSIIYTDMG 176 Query: 175 RDGTLAGSNV--SLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 DG + N+ +L P +A G + ++ L GV G+I+G++L G Sbjct: 177 PDGNMTEVNLEATLNFAKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDGIILGKSLDLGV 236 Query: 233 FTVKEAI 239 ++++EAI Sbjct: 237 YSLQEAI 243 >UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Arcobacter butzleri RM4018 RepID=A8ESN1_ARCB4 Length = 256 Score = 78.2 bits (191), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 45/212 (21%), Positives = 108/212 (50%), Gaps = 5/212 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L G L++ + K+ Y DP+ ++ + + + L +D+ + + + Sbjct: 7 VIPCLLLHKGG---LYKTEKFKKPTYIGDPINAIKIFNEKEVDELMFIDIDASVEDREPN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ + + +P+ GGGV++ E + + GV +V + S A+ + +++K FG Sbjct: 64 YKMIEDIASECFMPLCYGGGVKNIEQMKKIYALGVEKVSISSQAIINPNLIKEAARLFGN 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++++ +D++ D GNK++ ++ ++N+ ++ ++ +G ++ DG + G Sbjct: 124 QSVIVTIDIKKDFWGNKKIFINNGKKNTKLNPIDFIKQVESLGAGEIVINSCDNDGIMKG 183 Query: 182 SNVSLYEEV--CARYPQVAFQSSGGIGDIDDV 211 ++ L +E+ + P +A +G + I DV Sbjct: 184 YDIELLKEIKENTKVPIIALGGAGNLNHIKDV 215 >UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hisF n=224 Tax=Bacteria RepID=HIS6_STACT Length = 254 Score = 77.8 bits (190), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 50/190 (26%), Positives = 103/190 (54%), Gaps = 4/190 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ Q + RD G DP+ Y A+ A+ L +D++ ++ + Sbjct: 6 IIPCLDVKDGRVVKGVQ--FKGLRDIG-DPVALAAYYNAELADELVFLDISRTENGHQMM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + + +P+ +GGG+ S +D++ LL+ G +V + S+A+++ +VK E+FG+ Sbjct: 63 LDIIEETASKLFIPLTIGGGISSTDDISTLLKHGADKVSLNSSALRNPSLVKEASEKFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVS-GWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +A+D + +++ N + G ++ + + + V +G +L T + DG Sbjct: 123 QCICIAVDAKWEDERNDWFCYTHGGKQPTDIRVLDWVRQVEYLGAGELLVTSMDYDGVKQ 182 Query: 181 GSNVSLYEEV 190 G + L ++ Sbjct: 183 GFDHQLLNQI 192 >UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hisF n=36 Tax=cellular organisms RepID=HIS6_HALWD Length = 270 Score = 77.8 bits (190), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 107/228 (46%), Gaps = 19/228 (8%) Query: 2 IIPALDLI---DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 IIP +D+ DG ++ G + +Y DP+ + Y GA+ +D+T + Sbjct: 6 IIPCIDVDLDEDGNPA-VYTGINFEDLEYTGDPVEMAKQYNMAGADEFVFLDITASAVGR 64 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + + + + + +P+ VGGG+R+ +D+ + L AG +V + + A+++ +++ Sbjct: 65 ETMLETVSRVADEIFIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALETPELITTGASA 124 Query: 119 FGADALVLALDV--RIDEQGNKQVAVSG---W--------QENSGVSLEQLVETYLPVGL 165 FG+ +V+++D R DEQG ++V G W +E +G+ + + V G Sbjct: 125 FGSQCIVISVDARRRFDEQGENYLSVDGESCWFECTVKGGREGTGIDVLEWVTEAETRGA 184 Query: 166 KHVLCTDISRDGTLAGSNVSLYEEVC--ARYPQVAFQSSGGIGDIDDV 211 + I DGT G ++ L VC P +A G D+ +V Sbjct: 185 GELFINSIDADGTQDGYDIPLTSAVCDAVSTPVIASSGCGSPADMHEV 232 >UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WSE3_VEREI Length = 229 Score = 77.4 bits (189), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 5/202 (2%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y +QGA+ L +D+ + +I+ + VP+ VGGG+RS DV +L +G Sbjct: 17 YYSQGADELVFMDIVASLYQRNNLAGIIERAADQIYVPITVGGGIRSLHDVRTMLCSGAD 76 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 +V + + AV ++ ERFG+ +VL+++ + G + V +E++G+ + V Sbjct: 77 KVAINTAAVARPGLIAEVSERFGSQCMVLSVEAKRKSGGGWEAFVDNGREHTGLDVVAWV 136 Query: 158 ETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALR 215 + +G ++ T + ++GT G +V L V C P +A SGG G D+ Sbjct: 137 RQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTVAGCVTVPIIA---SGGYGRPSDLQQAA 193 Query: 216 GTGVRGVIVGRALLEGKFTVKE 237 G G+ + AL + T+ E Sbjct: 194 EAGASGLAIADALHWQRATIAE 215 >UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hisF n=27 Tax=cellular organisms RepID=HIS6_META3 Length = 275 Score = 77.4 bits (189), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 64/232 (27%), Positives = 119/232 (51%), Gaps = 35/232 (15%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ ++ + RD G DP+ + Y QGA+ L +D+ + + KR Sbjct: 6 IIPCLDIKNGRVVK--GTNFVELRDAG-DPVELSKIYNEQGADELVFLDIGASHE--KRD 60 Query: 62 I--PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 I L++ V +P+ VGGG+R+ +D +L AG ++ V + A+ + D++K E + Sbjct: 61 IIEHLVEKTADQVFIPLTVGGGIRTTDDFRRILRAGADKISVNTAAIHNPDLIKQSSELY 120 Query: 120 GADALVLALD---------------------VRIDEQGNK----QVAVSGWQENSGVSLE 154 GA +V+A+D V++D+ NK +V + G ++ +G+ Sbjct: 121 GAQCVVVAIDSKRHYVNEEDLDSKQLEDKNVVKVDK--NKYCWFEVFIYGGRKETGIDAI 178 Query: 155 QLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIG 206 + +T +G +L T + DGT G ++ L + + + + ++ +SGG G Sbjct: 179 EWAKTAEELGAGEILLTSMDADGTKDGYDIELTKSI-STHIKLPVIASGGCG 229 >UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M910_CALMQ Length = 254 Score = 77.4 bits (189), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 59/206 (28%), Positives = 103/206 (50%), Gaps = 5/206 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP +D +D +V + ++ R G DP+ Y +GA+ L L+D+T Sbjct: 11 IIPCMD-VDADIV-VKGVNFEGLRVMG-DPVELASRYEEEGADELFLLDITATVQGRSTF 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + A V++P+ VGGG+R ED A +AG +V + + AVK +V +G+ Sbjct: 68 LETVRNVAAAVSIPLGVGGGIRGMEDADAAFKAGADKVSINTAAVKDPSIVAKLSREYGS 127 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V+A+D R +V + G + + ++ T +G +L T I DGT AG Sbjct: 128 QSVVVAIDTR-RINNEWRVFIMGGRRETLLNAVDWARTVEELGAGELLVTSIDADGTRAG 186 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGD 207 ++ LY + A + +SGG G+ Sbjct: 187 YDIELYRRL-ADAVNIPVIASGGAGE 211 >UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M908_CALMQ Length = 228 Score = 76.6 bits (187), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 73/234 (31%), Positives = 120/234 (51%), Gaps = 24/234 (10%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQ--RDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 ++IP++DL +G VV+ +G G + + N+ L ++DY +H+VDL GA+ Sbjct: 4 LVIPSIDLSNGLVVKRVRGVKGSELVKLNLNEALSLVKDYP-----FIHVVDLNGAELGK 58 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + I + A VN +VGGGVR ED A LL +RVV+G+ AV++ ++ R Sbjct: 59 PINVDSIAKIGATVNGRCEVGGGVRVIED-AELLLKYCSRVVLGTVAVENPALLLNMINR 117 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVE--TYLPVGLKHVLCTDISRD 176 G D + ++LD + + GW GV ++++ + LP + V+ T++S + Sbjct: 118 LGVDKVAVSLD-----TDGEWLMTRGW----GVRARRIMDALSNLP-RVSAVIYTNVSVE 167 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQ--SSGGIGDIDDVAALRGTGVRGVIVGRAL 228 GT G V+ E+ R + + +GG+ DV L G G GVI+G AL Sbjct: 168 GTGMGPRVN--GELVKRLRDIGKEVYYAGGVSSCSDVEYLWGLGFDGVIIGYAL 219 >UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococcoides RepID=A5FQU7_DEHSB Length = 268 Score = 76.3 bits (186), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 105/217 (48%), Gaps = 10/217 (4%) Query: 2 IIPALDLIDGTVVR-LHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIP LD+ DG VV+ + D RD P Y+ QGA+ L +D+T + + Sbjct: 6 IIPCLDVKDGRVVKEIKFTDMADARD----PAEAAFVYSKQGADELAFLDITATIENSSI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +K +++ ++P+ GGG+R+ +D+ L GV+ V + + ++Q+ ++ RFG Sbjct: 62 HTDWVKKIISKTSLPLIAGGGIRNLQDIENLFTLGVSNVALNTITPQNQEFIRKAVARFG 121 Query: 121 ADALVLALDVRIDEQGNK----QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 ++ +++A+D + GN + + + + L + +G +L T D Sbjct: 122 SERIIVAIDGIKNPPGNGHPRLETVMPNGDDTHNLELVDWAKQVEALGAGAILLTSKDTD 181 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 GT G ++ + V R + +SGG G ++D+ A Sbjct: 182 GTKDGFDMEMIRSVT-RAVSIPVIASGGAGKLEDMYA 217 >UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hisF n=7 Tax=cellular organisms RepID=HIS6_THEP1 Length = 254 Score = 76.3 bits (186), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 103/210 (49%), Gaps = 9/210 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ DG VV+ ++ RD G DP+ + Y+ G + L +D+T + + K Sbjct: 6 IIACLDVKDGRVVK--GTNFENLRDSG-DPVELGKFYSEIGIDELVFLDITASVEKRKTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L++ + +++P VGGG+ E + L+ G +V + + AV+ ++ FG+ Sbjct: 63 LELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVEDPSLITKIARTFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A+V+A+D + G V ++N+G+ L V G +L T I RDGT AG Sbjct: 123 QAVVVAIDAK-KVDGEFVVFTYSGKKNTGILLRDWVVEVERRGAGEILLTSIDRDGTKAG 181 Query: 182 SNVSLYEEV--CARYPQVAFQSSGGIGDID 209 + + V P +A SGG G ++ Sbjct: 182 YDTEMIRFVRPLTTLPIIA---SGGAGKME 208 >UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=HIS6_THEYD Length = 278 Score = 76.3 bits (186), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 117/239 (48%), Gaps = 40/239 (16%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ RD G DP+ Y + A+ L +D+T + + K Sbjct: 6 IIPCLDVKDGRVVK--GVNFLNLRDAG-DPVENALYYNEEEADELVFLDVTASHEKRKII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ + V +P+ VGGG++S +D+ LL AG +V + +TAVK ++ RFG+ Sbjct: 63 IDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRFGS 122 Query: 122 DALVLALDV-RIDEQGN------------KQVAVSGWQENS----------------GVS 152 +V+A+D R+D+ N K+++ ++E+S ++ Sbjct: 123 QCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRPIDAIA 182 Query: 153 LEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEV--CARYPQVAFQSSGGIGDID 209 + +E + G +L T + RDGT G ++ L + P +A SGG G ++ Sbjct: 183 WAKKMEEF---GAGEILLTSMDRDGTKEGYDIELTRAISEAVSIPVIA---SGGAGTLE 235 >UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC 17748 RepID=C4FS06_9FIRM Length = 256 Score = 75.5 bits (184), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 109/242 (45%), Gaps = 11/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L + +G R+ G + DP+ + Y QGA+ L L+D+T + K Sbjct: 6 IIPCLGVANG---RVQNGVQFRDMVDAGDPVECAERYEIQGADELVLLDITATTEARKTF 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ V +P+ VGGG+ S ED+ L++AG +V + + A+ + ++ ++FG Sbjct: 63 TDIVLNASDKVFMPLTVGGGITSVEDMTQLMKAGADKVSINTAALSNPSLITEGAKKFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAV-SGWQENSGVSLEQLVE---TYLPVGLKHVLCTDISRDG 177 +V+ LDV+ + A G + G + +E + G +L T I R G Sbjct: 123 QGIVVCLDVKYNPFEKMWYAYGHGTSNDPGAQCKNALEWAKEAVDRGAGELLVTSIDRHG 182 Query: 178 TLAGSNVSLYEEVC--ARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 T G ++ LY+ + P AF +G I D+ T V G + L T+ Sbjct: 183 TGLGFDIELYQALAEVVDVPVTAFGGAGNIQHFVDL--FTKTNVTGALASALLHNKVLTI 240 Query: 236 KE 237 K+ Sbjct: 241 KD 242 >UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hisF n=14 Tax=Bacteria RepID=HIS6_BEUC1 Length = 256 Score = 75.5 bits (184), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 73/251 (29%), Positives = 116/251 (46%), Gaps = 13/251 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P LD+ G VV+ ++ RD G DP+ + Y A GA+ + +D++ + Sbjct: 7 VVPCLDVDGGRVVK--GVNFLDLRDAG-DPVELARRYDADGADEITFLDVSASTQGRATT 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V VP+ VGGGVR+ DV ALL AG +V V + A+ +++ + +G Sbjct: 64 LEMVSATAEQVFVPLTVGGGVRAVADVEALLRAGADKVGVNTAAIARPELLTEIAQHYGN 123 Query: 122 DALVLALDVR-----IDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 LVL++D R + +V G + +G+ + G VL I D Sbjct: 124 QVLVLSVDARRCPDGVVTDSGFEVTTHGGRTGTGIDAVEWAAEATSRGAGEVLLNSIDAD 183 Query: 177 GTLAGSNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 GT AG +V + E V A P VA SGG G ++D A G V+ G T Sbjct: 184 GTTAGFDVEMIEAVRAVVDTPLVA---SGGAGTVEDFVAAARAGADAVLAASVFHYGTLT 240 Query: 235 VKEAIACWQNA 245 + E A ++A Sbjct: 241 ISEVKAALRDA 251 >UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Thauera sp. MZ1T RepID=C4ZLR4_THASP Length = 226 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/240 (28%), Positives = 112/240 (46%), Gaps = 35/240 (14%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ + RD G DP+ + Y Q AE Sbjct: 6 IIPCLDVKSGRVVK--GVNFVELRDAG-DPVEIARRYDEQVAE----------------- 45 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 V +P+ VGGGVR EDV LL AG +V + + AV + +V + G+ Sbjct: 46 ---------QVFIPLTVGGGVRVVEDVRRLLNAGADKVSMNTAAVNNPQLVFEAASKVGS 96 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+D + G +V G + N+G+ + +G +L T + RDGT +G Sbjct: 97 QCIVVAIDAKQTAPGKWEVFTHGGRNNTGLDAIEWARKVESLGAGEILLTSMDRDGTKSG 156 Query: 182 SNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE-GKFTVKEA 238 +++L V R P +A SGG+G ++ +A G ++ ++ G+ TV+EA Sbjct: 157 FDLALTRAVSDAVRIPVIA---SGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHTVREA 213 >UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=4 Tax=Vibrio RepID=A6Y2G9_VIBCH Length = 262 Score = 74.3 bits (181), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 100/203 (49%), Gaps = 13/203 (6%) Query: 42 GAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVN--VPVQVGGGVRSEEDVAALLEAGVARV 99 GA+ +H+VDL A Q LI LV + V QV GG+RS E + + AG +RV Sbjct: 51 GAKWIHIVDLDAASGVGSNQ-RLIMDLVKHFSEKVQTQVCGGIRSNEILEQYILAGCSRV 109 Query: 100 VVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGW---QENSGVSLEQL 156 + S + + +++G + + +ALDV++ Q K +A GW Q N +L+ L Sbjct: 110 NISSMIFDKPKLCEKLLKKYG-EKIAIALDVKLVNQEYK-LATRGWNTLQGNLWTTLDWL 167 Query: 157 VETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG 216 + G + + TD+ R G+L N SL E+V + S GG+ +DD+ L Sbjct: 168 DNS----GCQRYVLTDVDRGGSLNHPNFSLLEQVLTK-TSTPIISGGGLCSLDDIDRLYQ 222 Query: 217 TGVRGVIVGRALLEGKFTVKEAI 239 G+ G ++G+ + + +K + Sbjct: 223 IGIEGAVLGQLIHTQQHQLKRFL 245 >UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hisF n=24 Tax=cellular organisms RepID=HIS6_HALS3 Length = 273 Score = 73.6 bits (179), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 96/217 (44%), Gaps = 15/217 (6%) Query: 2 IIPALD--LIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK 59 +IP +D L D ++ G ++ Y DP+ + Y GA+ +D+T + + + Sbjct: 7 VIPCIDVDLDDDGEPAVYTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASAEGRE 66 Query: 60 RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + + V +P+ VGGG+R +D+ L AG +V + S A+ +V + F Sbjct: 67 TMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRGAKAF 126 Query: 120 GADALVLALDV--RIDEQGNK-----------QVAVSGWQENSGVSLEQLVETYLPVGLK 166 G+ +V+++D R DEQG + V G +E +G+ + V+ G Sbjct: 127 GSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREGTGMDAIEWVQEAQRRGAG 186 Query: 167 HVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSG 203 + I DGT G +V L VC SSG Sbjct: 187 ELFVNSIDADGTQDGYDVPLTAAVCDAVSTPVIASSG 223 >UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJR2_DESAA Length = 262 Score = 73.6 bits (179), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 97/207 (46%), Gaps = 9/207 (4%) Query: 21 YGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGG 80 +G + G DP+ + + Y AQ A+ L +DL + + +I + +P+ VGG Sbjct: 31 FGPSTEIG-DPVSQAKIYQAQAADELVFLDLDASIEHRDALTDIIAKAAEEIFMPITVGG 89 Query: 81 GVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQV 140 GVRS ED LL G +V + + A++ +++ + FGA +V+++D + G +V Sbjct: 90 GVRSVEDCRRLLNHGADKVSINTGAMEIPELINQGSDMFGAQCIVVSIDYKKHPNGAYEV 149 Query: 141 AVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQ 200 G + ++G+ G +L T I RDGT G N+ L +V + Sbjct: 150 FTRGGKSSTGLDPVAWAVEAQHRGAGEILLTSIDRDGTRKGLNLELTAKVAGAV-DIPVI 208 Query: 201 SSGGIGDIDDVAALRGTGVRGVIVGRA 227 +SGG G L V G +VG+A Sbjct: 209 TSGGCG-------LASHFVDGFLVGKA 228 >UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW6_HODCD Length = 264 Score = 73.6 bits (179), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/237 (27%), Positives = 109/237 (45%), Gaps = 6/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP +D+ +G VV+ + + G L Y+ GA+ L +D++ + Sbjct: 9 IIPCMDVKEGHVVKGSK--FCGLVRVGEATLVA-NSYSVSGADELCFLDVSASSANRSIL 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I + +P+ VGGGVR +DV LL AG +V + S V S + + ++FG+ Sbjct: 66 YATISQVAESCLIPLTVGGGVRRVKDVGDLLRAGADKVSINSAGVLSPEFIARCVDKFGS 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D + + G +V G +GV + G +L T + RDG AG Sbjct: 126 QCVVVSIDCKASD-GAWEVCTHGGARPTGVDALEYACQAAQFGAGEILLTSVDRDGVKAG 184 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTVKE 237 +++L + V + V +SGG G++ A AL G V+ L + TV + Sbjct: 185 YDLALLKAV-SSLVSVPVIASGGGGELSHFALALIEGGASAVLTASLLHRNELTVSQ 240 >UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picrophilus torridus RepID=Q6KZD5_PICTO Length = 249 Score = 72.4 bits (176), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/205 (28%), Positives = 102/205 (49%), Gaps = 6/205 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II ALD+ +G VV+ + + +D G DP+ Y QGA+ + +D++ + Sbjct: 6 IIAALDVRNGRVVKGVR--FMDIKDAG-DPVENAVIYQDQGADEIVFLDISATDEKRDIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I L+K++ +N+P VGGG+RS + LL G +V + + A+++ ++K G+ Sbjct: 63 IDLVKSVSRELNIPFTVGGGIRSVKTALNLLREGCDKVFLNTYAIENPWIIKEISRETGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 LV+A+D + V + + NSG+ L + + +G +L T I DGT+ G Sbjct: 123 ANLVIAVDAMYNN--GYYVYKNAGRINSGLKLNEWLPMAEYLGAGEILLTSIDSDGTMKG 180 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIG 206 + L E A + +SGG G Sbjct: 181 FDNRLISE-AASMIDIPVIASGGAG 204 >UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC778 Length = 164 Score = 71.6 bits (174), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 35/110 (31%), Positives = 63/110 (57%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y+ GA+ L D+T + + K + + + +N+P VGGGV ED +L G Sbjct: 31 YSDCGADELVFYDITASNEERKTSLEFVTKVAENINIPFCVGGGVNKLEDFTDILRKGAD 90 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQE 147 +V + S+AVK+ ++++ +FGA +VL++D + +E+G+ V V G +E Sbjct: 91 KVSINSSAVKNPELIREASLKFGAQCVVLSIDAKKNEEGSWSVYVKGGRE 140 >UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria RepID=B4SDB6_PELPB Length = 256 Score = 71.2 bits (173), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 48/181 (26%), Positives = 90/181 (49%), Gaps = 1/181 (0%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y QG + L +D + +I++ + VP+ VGGG+RS ED +L +G Sbjct: 39 YYQQGVDELIYMDCVASLYDRNHLGDIIRSAAKDIFVPMTVGGGIRSVEDATQILRSGAD 98 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 +V V + AV + ++ RFG+ +VL+++ + + +V +E +G+ + V Sbjct: 99 KVAVNTAAVANPKLINEISRRFGSQCMVLSIEAKEVGKDRWEVYTDNGRERTGLDVIAWV 158 Query: 158 ETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT 217 + + +G VL T + R+GT G + +L + V A + +SGG+G +D+ + Sbjct: 159 KKGVAMGAGEVLLTSVDREGTRKGFDTALVKAVTAEV-SIPVIASGGMGKPEDLVGVVSV 217 Query: 218 G 218 G Sbjct: 218 G 218 >UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Bacteria RepID=C5BRY3_TERTT Length = 259 Score = 71.2 bits (173), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/217 (26%), Positives = 102/217 (47%), Gaps = 8/217 (3%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 DP + Y QGA+ L +DL + + ++ + +P+ VGGG+RS EDV Sbjct: 36 DPQIYAKRYYEQGADELLYIDLVASLYGRNKLKDIVSRTAQDIFIPLTVGGGIRSVEDVT 95 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENS 149 LL AG +V + + AV + +++ RFG+ +VL+++ + + +V +E+S Sbjct: 96 ELLAAGADKVAINTAAVANPALIEQVALRFGSQCMVLSIEAKRLGEDRWEVYTDCARESS 155 Query: 150 GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVC--ARYPQVAFQSSGGIGD 207 G + + + G +L T I ++GT G + +L V R P +A SGG G Sbjct: 156 GRDVIAWAKEAVERGAGEILLTSIDQEGTRKGFDTALTAAVAETVRVPVIA---SGGYGQ 212 Query: 208 IDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 + + A+ G I A + +E IA ++ Sbjct: 213 PEHINAITHQGSANAI---AFADALHFERETIASLKS 246 >UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Synechococcus sp. CC9311 RepID=Q0IDQ9_SYNS3 Length = 255 Score = 70.9 bits (172), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 60/237 (25%), Positives = 114/237 (48%), Gaps = 5/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ GT+++ Q + R G DP+ + Y+ GA+ L +D+ + Sbjct: 6 IIPRLDIKSGTLIKGVQME--GWRKVG-DPILAAKRYSEYGADELLFMDVVASLYERNTL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + + V +PV VGGG+R +DV LL G +V V + A+ +++ +R+G+ Sbjct: 63 HEIVEQVCSNVFIPVTVGGGIRKIKDVETLLSRGADKVSVNTGALLKPELINEISDRYGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A VL ++ + + + + SG + + V+ G ++ T I +DG G Sbjct: 123 QATVLTVECLKCGEKSWEALTDNGRNRSGREVIEWVKEAENRGAGEIVLTSIDQDGRGYG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKE 237 ++ L ++ ++ + +SGG G + L + T V G + +AL K + E Sbjct: 183 FDIDLV-DIVSQAVNIPIIASGGFGKPSHIVELIKSTDVSGAAIAQALHWEKVSFSE 238 >UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEW9_METST Length = 239 Score = 69.7 bits (169), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 61/252 (24%), Positives = 117/252 (46%), Gaps = 26/252 (10%) Query: 1 MIIPALDLIDGTVVRLHQG---DYGKQRD-YGNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 MIIP +D++ V G Y K R YG++PL GA+++++ DL D Sbjct: 4 MIIPVIDIMHNECVSGKSGRRSTYKKLRSIYGDNPLDIATALKEDGAQLIYIADL----D 59 Query: 57 PAKRQIPLIKTLVAGVNV-PVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 +R + + N+ PV + G+ S ED+ + + ++ + + S D ++ Sbjct: 60 KIERIDDNNNIISSINNIIPVMLDNGISSIEDIENN-KNICSYNILATETMTSLDNIEEI 118 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQ---LVETYLPVGLKHVLCTD 172 F+++ ++ LV+++D++ N ++ V+ N + LE L+ Y P K+ + + Sbjct: 119 FKKYDSNKLVVSIDIK-----NNELLVN----NKDIDLEDVIYLINKYKP---KYTIILN 166 Query: 173 ISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 IS GT G N ++ EE+ + P +GGI + D+ + ++G L EG Sbjct: 167 ISYVGTKKGVNTNIIEEITKKIPHTKCCIAGGIRN-SDIETYTKKNINNFLIGTLLHEGN 225 Query: 233 FTVKEAIACWQN 244 + K + +N Sbjct: 226 LSYKLYMESKKN 237 >UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Prochlorococcus marinus str. MIT 9313 RepID=HIS62_PROMM Length = 261 Score = 69.7 bits (169), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 51/178 (28%), Positives = 86/178 (48%), Gaps = 3/178 (1%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 DP+ + + Y AQ A+ L LVDL G D + + + + P+ VGGG+ S E V Sbjct: 39 DPVSQAKIYEAQLADELVLVDLEGTSDSWPILLDTLSNMSESLATPLSVGGGITSFEQVQ 98 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENS 149 LL+ G +VV+ S AV + ++ +G+ +V+++D+R + ++ V + G + Sbjct: 99 QLLDRGADKVVLNSGAVNNPQLIDLVANSYGSQCVVISIDIRKESDLSRHVYIDGGSTAT 158 Query: 150 GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYP-QVAFQSSGGIG 206 SL G +L T I DGT G ++ ++ RY + +SGG G Sbjct: 159 DWSLFSWANDCASRGAGELLITSIDNDGTGTGLDLDSIRQL--RYEVNLPLIASGGCG 214 >UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winogradskyi Nb-255 RepID=Q3SPZ7_NITWN Length = 258 Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 98/207 (47%), Gaps = 3/207 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L DG +V+ + + +R GN P+ + Y G + L ++D+ + R Sbjct: 6 LIPKFLLRDGRLVK-YTCFFDNERIAGN-PVTTAKVYNDYGVDELIVLDIVPSAASRARV 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + + +P VGGGV++ EDV ALL AG +V + S AV+ + V+ FG Sbjct: 64 EDIIGRMSEEIFMPFTVGGGVKTAEDVNALLRAGADKVSINSEAVRRPEFVREAARTFGD 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D + + V + G +E+ + + + +L + I RDGT+ G Sbjct: 124 QCITVSIDYKRIGSHHASVYIDGGREHVALDPVEWALRCEDLHCGEILMSSIDRDGTMQG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDI 208 ++ + + R V SGG G + Sbjct: 184 YDLEMINTLTKRL-GVPMIVSGGCGSL 209 >UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Prochlorococcus marinus RepID=A2C5V2_PROM3 Length = 500 Score = 68.9 bits (167), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 96/211 (45%), Gaps = 6/211 (2%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 DPL + YA G + L +D + I ++K+ + V +P+ GGG+R+ ED Sbjct: 44 DPLDMARKYAKAGIDELLYIDAVASLYGRNSLIEVLKSTSSEVFIPITAGGGIRNLEDAK 103 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENS 149 LL G ++ + + A++ ++ G+ +V+++ R + +E S Sbjct: 104 LLLSNGADKIAINTAALECPQLISELSNTLGSQCVVVSIQARASSSSSWDAMKESGREKS 163 Query: 150 GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCA--RYPQVAFQSSGGIGD 207 G+ + + +E +G +L T + +DGT + L ++V + P + SGG D Sbjct: 164 GIDVIKWIENVQLLGAGEILLTSVDQDGTCIKPDEILIQKVLPILKLPLIV---SGGFSD 220 Query: 208 IDDV-AALRGTGVRGVIVGRALLEGKFTVKE 237 + V AL + + V +G AL K V + Sbjct: 221 PNQVYQALTNSRISAVAIGAALHYQKTNVSD 251 >UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase subunit n=1 Tax=Erythrobacter litoralis HTCC2594 RepID=Q2N6D2_ERYLH Length = 264 Score = 67.4 bits (163), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 103/214 (48%), Gaps = 11/214 (5%) Query: 2 IIPALDLIDGT-VVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIP L L+DGT V+ HQ K Y D + Q + ++ A+ L +VD+ +D R Sbjct: 6 IIPVL-LLDGTSAVKTHQF---KPARYIGDIVNAAQIFNSKMADELIVVDIGYHQDNPSR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ L +P+ GGG+ S ++ AAL + G+ +V + + V+ +V+ +FG Sbjct: 62 P-EVIRHLAEECFMPLAFGGGISSVDEAAALFKDGIEKVSINTAFVEGGALVEEAARQFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++V ++D R + G+ QV G G+ ++ G +L I RDG Sbjct: 121 SQSVVASIDARREADGSYQVYSRGGTRALGIDPVEMARRAEAQGAGEILIQSIDRDGMRK 180 Query: 181 GSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVA 212 G + +L + P VA GG +DD+A Sbjct: 181 GYDRNLVRSIVDATTLPVVAL---GGADTVDDLA 211 >UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI6_KANKD Length = 265 Score = 67.0 bits (162), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 53/198 (26%), Positives = 98/198 (49%), Gaps = 9/198 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ G VV+ ++ +D G DP+ Y QGA+ + +D+ + Sbjct: 9 VIVCLDVAHGRVVK--GVNFKGLQDMG-DPVELAIRYQEQGADEIIFLDIKATLEQRANA 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + +++P VGGG+ + DVA L AG +V + S AVK D+V + FG+ Sbjct: 66 LEVVTRVAENLSIPFTVGGGLNTYADVAQFLNAGADKVALNSAAVKHPDLVDEIAKGFGS 125 Query: 122 DALVLALDVRIDE----QGNK--QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +V+A+D+ ++ QG+ +V ++G + ++ Q + G +L T + R Sbjct: 126 QCVVVAVDLNQEQDQKTQGSSEYEVYINGGHTLTDLNAMQWLTEIEQRGAGEILLTAMHR 185 Query: 176 DGTLAGSNVSLYEEVCAR 193 DGT G + L +V + Sbjct: 186 DGTGFGFDNELMSQVSKK 203 >UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermoproteaceae RepID=HIS4_PYRAE Length = 229 Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 69/232 (29%), Positives = 107/232 (46%), Gaps = 13/232 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP++D+ G V+ +G G + DPL + + A ++H+VDL GA+ Sbjct: 1 MIIPSIDIEGGRAVKRIRGQRGNY-IFQGDPLELAARF--RKAPLVHVVDLDGAEAGGLV 57 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I +I + + ++GGG+RS E V L VVGS K+ + + E + Sbjct: 58 NISVISKIAEILEGRCELGGGLRSLEAVERALSL-CQYAVVGSLPFKNWPLFRRAAELY- 115 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVG-LKHVLCTDISRDGTL 179 D L ++LD R +V V GW+E + S+ + V G V+ T + +GT Sbjct: 116 RDRLAVSLDYR-----GGEVLVGGWREKA-ASIAEAVRRLEEAGPYAAVIVTSVEVEGTG 169 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 G + + R + F +GG+ D +DV G GVIVG AL G Sbjct: 170 GGVKADIDVKSLKRIARRVFY-AGGVRDCNDVERAYALGFDGVIVGYALYAG 220 >UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID=Q1N2Y7_9GAMM Length = 223 Score = 65.5 bits (158), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 104/215 (48%), Gaps = 14/215 (6%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 D + ++ ++++ A+ + +VD+ A + + +PL+K L + +P+ +GGGV + ED Sbjct: 4 DAITNVKVFSSRKADEMVIVDIE-ATEKKRINLPLLKRLSSHCIMPLTIGGGVTTLEDAE 62 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENS 149 L G +V+V S +++ +FG A+V +LDV ++ N+ V VS +N Sbjct: 63 DLFSVGADKVLVNSAFYNRPEILTDISSKFGRQAVVFSLDVM--KKSNEYVPVS---KNG 117 Query: 150 GV----SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGI 205 V +L + VE + G ++ + DG + G +++L ++V + V +GG Sbjct: 118 SVKQSWTLRETVERAIEYGAGEIILNSVDCDGMMQGFDLNLCKQV-SDISSVPVVIAGGC 176 Query: 206 GDIDDVAALRGTGVRGVIVGRALL---EGKFTVKE 237 G +D +G V G E T+K+ Sbjct: 177 GTKEDCVLAVNSGADAVAAGSIFYWVGESILTIKD 211 >UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase subunit hisF3 n=18 Tax=cellular organisms RepID=HIS63_VIBVY Length = 260 Score = 65.5 bits (158), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 107/215 (49%), Gaps = 7/215 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L + + +V+ + GK Y DPL ++ + Q A+ L L+D+ ++ + Sbjct: 11 VIPVLLMREKGLVKTVKFKEGK---YVGDPLNAVKIFNEQEADELTLLDIDASRLGHEPD 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ + + +P+ GGG+++ E +L+ GV +V + S ++ ++ ER G Sbjct: 68 YVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERVGR 127 Query: 122 DALVLALDVRIDEQGNK--QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 ++V+ LDV+ G+K ++G ++ S ++E V+ +G ++ I DG + Sbjct: 128 QSIVVCLDVKKRLFGSKFDCFTINGTKKQSVDTIE-FVKQIQTLGAGEIVLNFIDNDGVM 186 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL 214 G ++ + A +V GG G +DD+A L Sbjct: 187 KGYDLDAVSKFKA-LVKVPLTVVGGAGCVDDIAKL 220 >UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SCV5_HAHCH Length = 255 Score = 64.7 bits (156), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 97/194 (50%), Gaps = 8/194 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA--K 59 IIP L L G +V+ Q + RD G DP+ + Y AQ A+ L +D+ + + + Sbjct: 6 IIPMLLLSQGRMVKGKQ--FSAFRDTG-DPVSAARIYNAQFADELVFLDVDANRQGSDFE 62 Query: 60 RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + LI + + +P+ VGGGV S E V L+++G +VV+ + A+++ ++ F Sbjct: 63 QLLNLIDKVSSECFMPLSVGGGVNSVEQVRRLVQSGADKVVITTAALENPGLINDASAIF 122 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G +V+ LDV+ E G ++ + + LE+ + G + + RDG + Sbjct: 123 GRQCIVVGLDVK-REDGAYRLYSHCGRHKTERELEEFIRDMTQRGAGEFIVNAVDRDGMM 181 Query: 180 AGSNVSLYEEVCAR 193 G ++ + + CA+ Sbjct: 182 QGYDLEMIK--CAK 193 >UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hisF n=3 Tax=Bacteria RepID=C8PKX5_9PROT Length = 306 Score = 64.7 bits (156), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 37/130 (28%), Positives = 75/130 (57%), Gaps = 3/130 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ D G DP+ + Y +GA+ L +D+T + Sbjct: 8 IIPCLDVKDGRVVK--GVNFVGLVDAG-DPVEIAKRYNEEGADELCFLDITASHLGRDTI 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ + + +P+ VGGG+R+ +D++ LL G ++ + S A+K+ +++ +FG+ Sbjct: 65 VDVVERVARELFIPLTVGGGIRTIDDISRLLNVGCDKISLNSAAIKNPNLIDEAANKFGS 124 Query: 122 DALVLALDVR 131 +V+A+D + Sbjct: 125 QCVVIAIDAK 134 >UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YI32_METS5 Length = 228 Score = 64.7 bits (156), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 63/232 (27%), Positives = 108/232 (46%), Gaps = 16/232 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P++D+ G V+ +G G G DPL ++ G +HLVDL A+ Sbjct: 3 VVPSIDISKGMAVKRVRGREGTGLVLG-DPLKIAEELRNMGYTSVHLVDLDAAEGKGD-N 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF-- 119 + +I+ ++ + + VGGG+R + L +G +VV+ + A D F R Sbjct: 61 VEVIERVMKDFS-EISVGGGIRDRSRLERFLSSGATKVVMSTLAFTKPDT----FRRVVA 115 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G + VL V +D ++V + GW E S +S E+ + +G++ V+ T + +GT Sbjct: 116 GYENRVL---VSVD-YCERKVLIKGWNE-SAMSFEEAISHVNSLGVRGVIFTYVCNEGTR 170 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 G + + V + + +GGIG I D+ L G IVG +L G Sbjct: 171 NGIDPEIGRYVNLVQGEKGY--AGGIGSIQDLQELDKMGFHFAIVGMSLYAG 220 >UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Proteobacteria RepID=A6T0B3_JANMA Length = 253 Score = 64.3 bits (155), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/225 (23%), Positives = 106/225 (47%), Gaps = 5/225 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P L + G +V+ Q K+ Y DP+ ++ + + + L L+D+T + Sbjct: 6 VMPCLLMDQGALVKTVQF---KKPTYIGDPVNAVRIFNQKEVDELLLIDITATTEKRGID 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ LV +P+ GGGV + D+ L G+ ++ + + A+ + ++V+ FG Sbjct: 63 FETLEKLVTECFMPICYGGGVDNLVDMRRLYHLGIEKISLSAAAITNPELVREAAAEFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A+V+ LDV+ + G V + ++ S ++ G +L I +DGT +G Sbjct: 123 QAIVVTLDVKKNLFGKHTVRTHQGKTDTKRSPVEVAREMEQAGAGEILLYSIDKDGTWSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVG 225 ++ L + V R + + GG G++ + +A+ G V +G Sbjct: 183 FDLDLIQNV-TRAVGIPVIACGGAGELAHLRSAVNEAGASAVAIG 226 >UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKR3_FIBSS Length = 263 Score = 64.3 bits (155), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 98/212 (46%), Gaps = 7/212 (3%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 DP+ Y+ +G + L D+T + + + +I+ + V +P VGGG+R+ +D+ Sbjct: 31 DPVEMGARYSDEGVDELVFYDITASAENRPCDMEMIRQIAKRVFIPFAVGGGIRNLDDMH 90 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNK-----QVAVSG 144 L AG +V V S AV +++ + FG +VL +D + +K +V + G Sbjct: 91 EALLAGAEKVSVNSLAVLHPEIIAEGAKAFGRQCIVLGMDAKFVGVSDKIPSGYEVFIRG 150 Query: 145 WQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGG 204 ++ G+ Q + +G+ + I DG G +++ + + A+ QV +SGG Sbjct: 151 GRQAMGIDALQWAKRAEELGVGEICLNSIDTDGVKNGYELTITDMI-AKAVQVPVIASGG 209 Query: 205 IGDIDDVAAL-RGTGVRGVIVGRALLEGKFTV 235 G + L R T +V + G +TV Sbjct: 210 AGTPAHIVDLFRKTSADAALVASMVHFGDYTV 241 >UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Sulfolobus RepID=HIS4_SULSO Length = 232 Score = 63.9 bits (154), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/231 (23%), Positives = 107/231 (46%), Gaps = 9/231 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP++D+ G V+ +G G GN P+ +G +H+VDL A+ + Sbjct: 4 IIPSIDISFGKAVKRIRGVRGTGLVLGN-PIELANKLYNEGYSRIHVVDLDAAEGVGNNE 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + + G + +QVGGG+R E L+ V ++ + + ++ G Sbjct: 63 MYIKEICKIGFD-WIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGN 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++ V ID K+V +SGW+E S + + ++ + L ++ T ++ +GT+ G Sbjct: 122 NRVI----VSIDYDDTKRVLISGWKERS-MEIIDGIKKVNELELLGIILTYVTNEGTVKG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 + S+ + A+ + + +GG+ D+ L+ G +IVG A K Sbjct: 177 IDYSVKD--YAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNK 225 >UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Sulfolobus acidocaldarius RepID=Q4J8J0_SULAC Length = 226 Score = 63.9 bits (154), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P++D+ + V+ +G G G DPL ++ ++G + +H+VDL A+ + Sbjct: 3 VMPSIDISNKVAVKRIRGKGGSGIILG-DPLKIAKEIISEGYDAIHIVDLDAAEGLGDNK 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +IK + QVGGGVR E +LE + +VV + + ++ G Sbjct: 62 -DIIKQICTLGFSWTQVGGGVRKLEIAKDILEY-CSSIVVSTLPITNRQEYDKIISGVGV 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + L+ ID N V + GW+E S V + L++ L G V+ T I +GT G Sbjct: 120 DKVFLS----IDYDDNGYVLIKGWKEKS-VKVSDLLD--LESG--GVIFTYIPNEGTKGG 170 Query: 182 --SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 +NV Y + + + A GGIG +DD+ L+ G I+G + G Sbjct: 171 IDNNVVEYVKSVKKIKEYA----GGIGSLDDLLKLKSFGFDYSIIGMSFYNG 218 >UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Prochlorococcus marinus str. NATL1A RepID=A2C1S3_PROM1 Length = 248 Score = 63.9 bits (154), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 50/187 (26%), Positives = 91/187 (48%), Gaps = 6/187 (3%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 DP +Y QG E + +D + +I+ V VP+ +GGG+RS +DV+ Sbjct: 28 DPQELAVEYYKQGIEEIVFMDAVASLYNRNNLFHIIQKACEKVFVPIALGGGLRSLDDVS 87 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENS 149 L AG +VV+ + V D+ K +++G+ LV +++ + E + +V V +E + Sbjct: 88 KALNAGADKVVINTALVNRIDLAKEIAQKYGSQCLVGSIEAK-RENDSWRVYVDNGREPT 146 Query: 150 GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEV--CARYPQVAFQSSGGIGD 207 ++ G+ +L T I ++GT G ++ L +++ R P +A SGG G+ Sbjct: 147 KHNVVDWAIKLKEAGVGEILLTSIDQEGTSKGFDIELIKQINESIRCPIIA---SGGYGN 203 Query: 208 IDDVAAL 214 +A L Sbjct: 204 KKHLADL 210 >UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L5A7_9DELT Length = 261 Score = 63.2 bits (152), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 44/140 (31%), Positives = 65/140 (46%), Gaps = 5/140 (3%) Query: 74 VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRID 133 VP+ VGGGVR ED LL AG +V + + A + +++ E FG +V+++D R Sbjct: 74 VPLTVGGGVRRIEDFQELLRAGADKVSLNTAAFRDPELITRAAEAFGNQEVVVSIDARRH 133 Query: 134 EQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCA- 192 G +V V G +E +G G +L I RDG G ++ L V Sbjct: 134 ADGRYEVFVGGGREATGADPRDFAREAERRGAGEILLNAIDRDGGKQGYDLELVRRVATA 193 Query: 193 -RYPQVAFQSSGGIGDIDDV 211 P +A GG+G I+ V Sbjct: 194 VSIPVIAL---GGVGRIEHV 210 >UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hisF n=19 Tax=cellular organisms RepID=HIS6_DESAA Length = 260 Score = 63.2 bits (152), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 8/190 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ DG + + + D G DP+ + Y G + L D+T + + Sbjct: 6 VIVCLDVRDGKTTKGIK--FKGNVDIG-DPVDMARVYYEAGCDELVFYDITASHEKRGIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ + + +P VGGG+ S ED+ +L AG ++ V S AVK+ ++ E FG Sbjct: 63 IDVVRRVAETIFIPFSVGGGISSVEDMRDVLLAGAEKISVNSAAVKNPKIITQGAEAFGN 122 Query: 122 DALVLALDVRIDEQGNK-----QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +VL +DV+ E+ K ++ ++G + G+ + +G + I D Sbjct: 123 QCVVLGMDVKKVEKSEKIPSGYEIVINGGRTYMGIDALWWAQEGERLGAGEICLNSIDAD 182 Query: 177 GTLAGSNVSL 186 GT G + L Sbjct: 183 GTKEGYELEL 192 >UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7I5_9DELT Length = 289 Score = 62.8 bits (151), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/215 (24%), Positives = 100/215 (46%), Gaps = 12/215 (5%) Query: 2 IIPALDLIDGTVVR-LHQGDY---GKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 IIP LD+ +V+ +H GK D+ + Y GA+ L D + Sbjct: 5 IIPRLDIKGPNLVKGIHFEGLRVLGKPEDFA-------RHYYENGADELFFQDAVASLYD 57 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 ++K + + +P+ VGGG+RS +D+ A+L AG +V + + A+K ++++ Sbjct: 58 RNSLHDIVKRTSSEIFIPLCVGGGLRSVDDIRAVLRAGADKVAINTEAIKRPELIREASV 117 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 FG+ +V++++ G + V +E +GV+ + + +G ++ T I ++G Sbjct: 118 AFGSSTIVVSIEAIRRANGEWEALVEYGRETTGVNAVEWAKRACELGAGELMITSIDQEG 177 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA 212 T G ++ L + A V + GG G D A Sbjct: 178 TGKGYDIELTRAI-ASAVSVPVIAGGGCGSPADAA 211 >UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BNI2_9BACT Length = 248 Score = 61.2 bits (147), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 38/170 (22%), Positives = 81/170 (47%), Gaps = 5/170 (2%) Query: 21 YGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGG 80 + R GN P+ + + ++G + L +D+ K K + L+K ++ +PV +GG Sbjct: 23 FKNPRMVGN-PVQTARVFNSRGVDELIFLDIYATKQSRKINLSLVKEVIKECYMPVSIGG 81 Query: 81 GVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQV 140 G+++ + + LL+ G +VV+ S A+ + +K FG+ + +++DV Sbjct: 82 GIQTIDQINDLLKIGADKVVIKSKALTDKKFLKEAINFFGSQCICISVDVLFVNNNYLIY 141 Query: 141 AVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEV 190 G + +SLE+ + + +L ++ DG + G ++ L +V Sbjct: 142 NDLGLK----ISLEEFITEMSLINAGELLVNSVNNDGVMNGFDIDLINKV 187 >UniRef50_P72139 Putative imidazole glycerol phosphate synthase subunit hisF2 n=9 Tax=cellular organisms RepID=HIS62_PSEAE Length = 251 Score = 60.8 bits (146), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 46/212 (21%), Positives = 96/212 (45%), Gaps = 5/212 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L D +V+ + K+ Y DP+ ++ + + + L L+D+ ++ + Sbjct: 6 VIPCLLLKDRGLVKTVKF---KEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQEPN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI + +P+ GGG+++ E + GV +V + + A+ +++ ++FG+ Sbjct: 63 YELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V ++D R G V + S + + G+ + I RDG G Sbjct: 123 QSVVGSIDCRKGFWGGHSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSIDRDGVQKG 182 Query: 182 SNVSLYEEVCA--RYPQVAFQSSGGIGDIDDV 211 + +L E + + P +A +G I D+ D+ Sbjct: 183 FDNALVENIASNVHVPVIACGGAGSIADLIDL 214 >UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=uncultured marine bacterium 440 RepID=Q6SHC0_9BACT Length = 262 Score = 59.3 bits (142), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 54/231 (23%), Positives = 107/231 (46%), Gaps = 23/231 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN--DPLPRLQDYAAQGAEVLHLVDLT------- 52 IIP L + +G +VR ++ K + GN + RL DY + L +D+T Sbjct: 7 IIPVLFIKNGLIVR--SQNFYKHQFIGNVIEQAKRLNDY---DVDELVYIDITRNDNYDL 61 Query: 53 GAKD---PAKRQI-PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKS 108 G D +KR I +IK + +P+ GGG+RS +D + AG ++ + S K Sbjct: 62 GRDDLLVKSKRDIMSIIKDISKVCFMPLTFGGGIRSVDDAVNRIRAGADKITINSLLYKD 121 Query: 109 QDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGW-QENSGVSLEQLVETYLPVGLKH 167 ++VK G+ A+V ++D +I + K + + + Q+N+ + L ++ +G+ Sbjct: 122 LNIVKKIISEIGSQAVVASIDYKIINE--KLIIFNNFGQDNTNIELIDFIKKIENLGVGE 179 Query: 168 VLCTDISRDGTLAGSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRG 216 ++ DG G +++ +++ P +A +G + + ++G Sbjct: 180 FFIQNVELDGMQKGFDLNNIKKIVNSVNLPVIACSGAGSLEHFLEAVKIKG 230 >UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=1 Tax=Cyanothece sp. PCC 7425 RepID=B8HVG9_CYAP4 Length = 226 Score = 58.9 bits (141), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 58/177 (32%), Positives = 84/177 (47%), Gaps = 14/177 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPAL +++G H+ Y + DP+ + +A QGA LHL+D G A Sbjct: 3 IIPALKIMEGFCCH-HRQPY----RFNCDPVAMAEQWANQGATRLHLIDCNGVTTGAMLN 57 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P I +V V VPVQV G + S + L GV RVVV + + ++V E F Sbjct: 58 LPTIAAIVQQVKVPVQVEGTIYSRAQIETLFAIGVDRVVVDGS-IGWSELVADLCEHFSG 116 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 +V E + +VA SG E +G+ L E VG ++ TDI+R G+ Sbjct: 117 KIMVNL------EAYDGRVACSG--ELTGLLATTLAERAEAVGAAGIIYTDIARQGS 165 >UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H029_9FIRM Length = 250 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/211 (24%), Positives = 106/211 (50%), Gaps = 7/211 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+P +D+ G VV+ + + +D DP+ + Y A GA++L D+ + + + Sbjct: 4 LIMPCMDIRHGKVVKGIK--FEGVKDVA-DPVELAKYYDATGADILVFYDIAASVEDKQI 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L K++ A ++P+ GGG+++ EDV +++ G V + + A+ + D++ E+ G Sbjct: 61 YEGLFKSVRAVSDLPLVAGGGLKTIEDVDNIIKLGADMVSINTGAIDNPDLLNEAAEKIG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGV-SLEQLVETYLPVGLKHVLCTDISRDGTL 179 ++ ++L++D + G V + ++G+ +LE + E Y G ++ I DG Sbjct: 121 SENVILSVDAK-KVNGEYHVFRNAGMMDTGLDALEWISEGY-DRGAGILVLNSIDTDGVK 178 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 AG ++ + + +SGG G + D Sbjct: 179 AGYDIEML-KAAGEVTDAKIVASGGAGKMQD 208 >UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Synechococcus sp. WH 8102 RepID=HIS62_SYNPX Length = 269 Score = 58.9 bits (141), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/163 (23%), Positives = 77/163 (47%), Gaps = 8/163 (4%) Query: 24 QRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVR 83 QR+Y +Y+A + L ++D++ + L+ L + VP+ GGG+R Sbjct: 35 QRNYN-------FNYSATFIDELIILDISRKSRDINKFATLLYNLSENIFVPITAGGGIR 87 Query: 84 SEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVS 143 S ED L E G +V + ++ ++ + + +G +LV ++D + D K + Sbjct: 88 SFEDAKVLFENGADKVCLNTSLIQCPHVSEKISSVYGQQSLVASIDFKHDHGDFKFFIDN 147 Query: 144 GWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSL 186 G E ++++L+ P+ +L + RDGT G +++L Sbjct: 148 GLIE-VQYNIQELISFLDPLPFCEILLQSVDRDGTGTGFDLTL 189 >UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E201_GEOLS Length = 282 Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 44/191 (23%), Positives = 88/191 (46%), Gaps = 3/191 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +V+ G + + DP+ Y GA+ L D+ + Sbjct: 6 IIPRLDIKGPNLVK---GIHLEGLRVLGDPIAFAHYYYENGADELIYSDIVASLYQRNSI 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L+ V +P+ + GG+R+ D+ L AG +V + + A+++ D + FG+ Sbjct: 63 LDLVTETSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVRVFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A++V ++ + +++SG+ V+ +G +L T I+ +GT G Sbjct: 123 STIVVAVEVVRNDDNSLIAYTENGRQSSGIEAVSWVQRVEELGAGEILLTSINAEGTGDG 182 Query: 182 SNVSLYEEVCA 192 ++ L V + Sbjct: 183 YDMDLINRVVS 193 >UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41F9C Length = 231 Score = 57.4 bits (137), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 27/240 (11%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY---------GNDPLPRLQDYAAQGAEVLHLVDLT 52 IIP +DL++ V G G + Y +DPL + GA+ +++ DL Sbjct: 4 IIPVIDLMNSVAV---SGKSGNRETYTPLQTIYASSSDPLEIALSLKSAGAKEMYIADLD 60 Query: 53 GAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMV 112 + I IK V V +PV + GV E LLE +++V + ++S + + Sbjct: 61 FIERNGNNNIFKIKE-VNSV-LPVILDVGVDKLETFEFLLEFAY-KIIVATETLESIEEL 117 Query: 113 KGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTD 172 FE++ + +++++DV+ +E + +N + LE E + ++ D Sbjct: 118 GKIFEKYPKERIIVSVDVKNNEL---------YAKNMDLDLEGFKEVLRRIDPNEIILLD 168 Query: 173 ISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 IS GT G N L E ++ GGI D+++ L G+R +VG AL +G+ Sbjct: 169 ISSVGTEGGFNKPLLESFEEFKDKIIL--GGGITP-DEISQLDALGIRKALVGTALHKGQ 225 >UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase subunit HisF n=1 Tax=Campylobacterales bacterium GD 1 RepID=B6BGE0_9PROT Length = 254 Score = 57.0 bits (136), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 33/141 (23%), Positives = 71/141 (50%), Gaps = 1/141 (0%) Query: 74 VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRID 133 +P+ VGGG+R+ +D+ L +G +V + + A++ + ++FG+ ++ ++ + Sbjct: 75 IPITVGGGLRNLQDIQEALNSGADKVAINTQAIREPSFITTASKQFGSQCIISSIVAKKI 134 Query: 134 EQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCAR 193 + G + + +E +GV + + +G ++ T I ++GT G ++ L + V A Sbjct: 135 DDGKWEAYIENGREPTGVDVLAWAKEVQELGAGEIMLTSIDKEGTKKGFDLELNKAV-AE 193 Query: 194 YPQVAFQSSGGIGDIDDVAAL 214 + SSGG G D+ L Sbjct: 194 LVNIPVISSGGAGSTKDIVHL 214 >UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase HisF n=1 Tax=Sphingobacterium spiritivorum ATCC 33300 RepID=C2G0W0_9SPHI Length = 263 Score = 57.0 bits (136), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 35/126 (27%), Positives = 68/126 (53%), Gaps = 9/126 (7%) Query: 65 IKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADAL 124 + LV G +PV VGGG+RS ED L ++G ++V+ ++ D+VK +++G+ ++ Sbjct: 69 VSRLVEGTYMPVAVGGGIRSLEDAEMLFKSGADKIVLNTSLSSDPDLVKLIVQKYGSQSV 128 Query: 125 VLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP----VGLKHVLCTDISRDGTLA 180 V ++D + + + ++ + EN +++ + E YL + + V + RDGT Sbjct: 129 VASIDY-LKKGESSEIFI----ENGSLNINEGFENYLSHLKDLNVGEVYLNSMERDGTGF 183 Query: 181 GSNVSL 186 G + SL Sbjct: 184 GYDFSL 189 >UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LAC8_MAGSM Length = 260 Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/212 (21%), Positives = 100/212 (47%), Gaps = 3/212 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L +G +V+ + + K Y DP+ + + + + L ++D++ ++ A+ Sbjct: 6 VIPTLLLKEGRLVKTVRFNQAKA-TYVGDPVNTAKIFNDKEVDELAVLDISASRRGAEPD 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ L + +P+ GGGVR+ + + L +GV +V++ + +++ + +G+ Sbjct: 65 FECVEQLASECFMPLLYGGGVRNLQQIQRLFHSGVEKVMLNTAFFSGSGLLQEAVKIYGS 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +L +++DV+ D G +V G Q +G+ + G +L + +DG G Sbjct: 125 QSLGVSIDVKKDLWGRYRVMSQGGQRKTGLDPVVAAQQAEQAGAGELLLNAMDQDGMQQG 184 Query: 182 SNVSLYEEVC--ARYPQVAFQSSGGIGDIDDV 211 ++ L + V P +A + + D V Sbjct: 185 YDLELVQRVSRGVAIPVIAVGGAASVADFRTV 216 >UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlorococcus marinus clone ASNC1363 RepID=Q1PLA2_PROMA Length = 268 Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 46/180 (25%), Positives = 87/180 (48%), Gaps = 13/180 (7%) Query: 37 DYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGV 96 D A + L ++D+T + ++ ++ + + VP+ +GGG+ S E ++G Sbjct: 42 DNVAYHIDELLILDVTRGRKDSEEFCKVVTQISENIFVPLTIGGGINSLEKAKLFFKSGA 101 Query: 97 ARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGV----S 152 +V + S+ + + +V + +G LV ++DV + N++ V N+G S Sbjct: 102 DKVSINSSLL-DESLVTQIVKNYGKQCLVGSIDVL---KKNEEYYV---YSNNGTKLVSS 154 Query: 153 LEQLVETY-LPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 L + E + + I++DGT G ++SL E V A+ +V F SGG+G I D+ Sbjct: 155 LNKFFENKEFFNNIGEIYINSINQDGTGNGLDISLAEFVSAK-SEVPFIISGGVGKITDI 213 >UniRef50_D2MIW0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIW0_9BACT Length = 104 Score = 55.5 bits (132), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 35/101 (34%), Positives = 55/101 (54%), Gaps = 3/101 (2%) Query: 142 VSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQS 201 + GW S + E ++ + L V+ T+ISRDG L G NV+ + P V + Sbjct: 1 MHGWTNVSESTAEPVLASLKEYPLAGVIFTEISRDGMLEGPNVAALRDAVRASP-VPLIA 59 Query: 202 SGGIGDIDDVAALR--GTGVRGVIVGRALLEGKFTVKEAIA 240 SGG+ ++D+ A++ G + GVIVG+AL EG + A+A Sbjct: 60 SGGVTRVEDIRAIKRLGQKIIGVIVGKALYEGTLDLPAALA 100 >UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit HisF n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BR00_9RICK Length = 254 Score = 54.7 bits (130), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 83/178 (46%), Gaps = 8/178 (4%) Query: 31 PLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAA 90 PL ++ Y ++ + + D++ + I ++ V+VP+ +GGG+ + Sbjct: 33 PLTTVKIYNSRDVDEILFFDISRNNKIIDKD--FILSITDCVSVPITIGGGIEKISQMND 90 Query: 91 LLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSG 150 L E G +V + S K+ +++ +RFG+ A+ +++DVR + Q N + + S Sbjct: 91 LFEYGADKVAINSIIYKNPNIIDEASKRFGSQAITVSIDVRKNNQ-NYECYYDLGKIKSD 149 Query: 151 VSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVC--ARYPQVAFQSSGGIG 206 L L+ + G ++ I+ DG + G + L ++ A P VA SGG G Sbjct: 150 RKLNDLLVECVNRGAGEIVINCINNDGLMKGYDNELIQQTSSLANIPIVA---SGGAG 204 >UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UE29_9RHOB Length = 261 Score = 53.5 bits (127), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 93/201 (46%), Gaps = 15/201 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLT-------GA 54 +IP L L++G +VR + + G DPL + + + L +D++ G Sbjct: 6 LIPVLLLMNGQLVRSET--FTTHQIIG-DPLHEVARFNEWKVDELIYLDISRTAGLAQGR 62 Query: 55 KDPAKRQ----IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 +D R + +++ + + +P+ GG V S + V + + G +V + + A ++ D Sbjct: 63 RDAGNRAYADAMDVLEAVASHCFMPLTWGGHVTSLDQVRDIFKRGADKVAINTAAYETPD 122 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 ++ +RFGA A+V+++D R E G +V G + +G + G +L Sbjct: 123 LITQVSKRFGAQAMVVSIDARQIENG-YEVMTQGGRTATGRDPVSWAKEAEDRGAGEILL 181 Query: 171 TDISRDGTLAGSNVSLYEEVC 191 + RDG G + +L E+V Sbjct: 182 QSLDRDGRGTGYDTTLIEQVS 202 >UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Roseburia RepID=C7GBG4_9FIRM Length = 252 Score = 53.1 bits (126), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 43/181 (23%), Positives = 80/181 (44%), Gaps = 4/181 (2%) Query: 32 LPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAAL 91 LP ++ Y + + L L+D+ + I+ VP VGGG+ + + L Sbjct: 33 LPAIKVYNMREVDELILLDIEATNEKRDPDYDEIRDFSRECFVPFCVGGGICHIDQIKNL 92 Query: 92 LEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVR-IDEQGNKQVAVSGWQENSG 150 L AG +V + S A + ++ + FG+ +V ++D R ID G ++G Sbjct: 93 LRAGADKVAINSAAYDNLSLITEGAKLFGSQCIVASIDCRKID--GEYHCFSHNGSVDTG 150 Query: 151 VSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 L+ + + G +L T + DGT+ G +V + ++ V +SGG G+ + Sbjct: 151 WLLQDWIIKVVEAGAGEILLTSVELDGTMEGYDVEMI-KIATSLVNVPVIASGGAGNYEH 209 Query: 211 V 211 + Sbjct: 210 M 210 >UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase subunit hisF2 n=17 Tax=delta/epsilon subdivisions RepID=HIS62_CAMJJ Length = 248 Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 32/130 (24%), Positives = 68/130 (52%), Gaps = 4/130 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP + L +G +V+ ++ R G+ ++ Y A+ + L ++D+ +K + Sbjct: 6 IIPCVLLKNGQLVK--SIEFKDFRTIGH-LTSTMRIYNARNVDELIILDIDASK-SGEID 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ L +P+ +GGG+++ ED+ +L G ++ + S A++ D + RFG+ Sbjct: 62 FESIEDLAKECFMPLTIGGGIKTLEDIQKILNLGADKISINSKALEDMDFISKAANRFGS 121 Query: 122 DALVLALDVR 131 +V ++DV+ Sbjct: 122 QCIVCSIDVK 131 >UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Vibrio vulnificus YJ016 RepID=HIS62_VIBVY Length = 272 Score = 51.6 bits (122), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 45/169 (26%), Positives = 78/169 (46%), Gaps = 14/169 (8%) Query: 50 DLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQ 109 D+ +K+ + + L+ VP+ VGGG+++ E + LL+AG +V + + A+ Sbjct: 54 DIDASKEFREPNVDLVSWAAKECFVPLTVGGGIKTLEHIRNLLKAGADKVTINTKAIDDP 113 Query: 110 DMVKGWFERFGADALVLALDVRIDEQGN----KQVAVSGWQENSGVSLEQLVETYLPVGL 165 D +K FG+ + +++D +QGN + V + VE+Y G Sbjct: 114 DFIKNAASVFGSQCITVSVDAI--KQGNVYKLYDYRDGRVLDVDVVDWVRKVESY---GA 168 Query: 166 KHVLCTDISRDGTLAGSNVSLYEEVC--ARYPQVAFQSSGGIGDIDDVA 212 +L + RDG+ G +V L + V P +A GGIG D +A Sbjct: 169 GEILLNSVDRDGSREGYDVELLKTVSGIVSIPVIAL---GGIGRFDQLA 214 >UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NHA2_KYTSD Length = 470 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 97/219 (44%), Gaps = 21/219 (9%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDV 88 +DP + + AQGAE LHLVDL A A L++ LV +VPV+V GG+ S DV Sbjct: 26 SDPQAAVDHWVAQGAERLHLVDLDRATG-AGENDALLERLVRRASVPVEVSGGILSPRDV 84 Query: 89 AALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQEN 148 L G V S W + GA+ + V ID G++ VA Sbjct: 85 ERALSWGAVAVTTSSALWADPAAALEWLQGCGAE-----VQVGIDLVGDRVVA-----RG 134 Query: 149 SGVSLEQLVETYLP---VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGI 205 + ++L + + + +G + + + DG + G +++ + +SGG+ Sbjct: 135 TDLALGPVADLWPDLAGLGERRWVLASAAADGRMTGPDLAGL-RAATEHLTGTLIASGGV 193 Query: 206 ---GDIDDVAALR---GTGVRGVIVGRALLEGKFTVKEA 238 GD+ V++LR G V VI+G AL G + A Sbjct: 194 STTGDLVAVSSLRGVAGPAVGEVILGAALYAGAVDLGRA 232 >UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methanobrevibacter smithii RepID=A5UNR3_METS3 Length = 229 Score = 51.2 bits (121), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 57/241 (23%), Positives = 109/241 (45%), Gaps = 26/241 (10%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQI 62 +P LDL D V G G + Y PL + +A ++ + + + GA + + Sbjct: 5 VPVLDLKDNIAV---SGKSGLRDTYT--PLQTVFAPSANPVDIANGLSINGADELYIADL 59 Query: 63 PLIK------TLVAGVN--VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 LI+ V VN +PV + GV+ E L+ +++V + +KS +K Sbjct: 60 DLIEGNGHNIHDVKMVNSILPVMLDAGVKDFESFTFFLDYAY-KIIVPTETIKSIGEIKK 118 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 FE++ + +V+++DV+ +E + +N +SL + E + ++ DI+ Sbjct: 119 IFEKYPKERIVVSVDVKDNEL---------YSKNLNISLAEFKEILEELDPDEIILLDIT 169 Query: 175 RDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 GT G N L ++ ++ +GG+ + V+ L G++ V+VG AL G+ Sbjct: 170 GVGTQKGYNQELLDDFKDLKDKLII--AGGLNN-KSVSELEDMGIKKVLVGTALHSGEMK 226 Query: 235 V 235 + Sbjct: 227 L 227 >UniRef50_C4Z9Z2 Imidazole glycerol phosphate synthase subunit HisF, putative n=3 Tax=Clostridiales RepID=C4Z9Z2_EUBR3 Length = 427 Score = 49.7 bits (117), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 48/93 (51%) Query: 36 QDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAG 95 Q Y G + + + DL+ D ++ I I+ + +++ V GG + EDV LL AG Sbjct: 36 QLYNDSGIDKIIIFDLSTDDDEHEKNIHTIENINRNIDIKVCAGGNINRIEDVKKLLYAG 95 Query: 96 VARVVVGSTAVKSQDMVKGWFERFGADALVLAL 128 +V+ +T S ++ E+FG D ++L++ Sbjct: 96 CLQVIFNATKDSSLELANVASEKFGKDKILLSI 128 >UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. AS9601 RepID=A2BSD9_PROMS Length = 254 Score = 48.9 bits (115), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/219 (18%), Positives = 96/219 (43%), Gaps = 8/219 (3%) Query: 15 RLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTG-AKDPAKRQIPLIKTLVAGVN 73 R+ + K Y DPL ++ + ++ + + ++ K ++ + Sbjct: 17 RMIKRSKFKNYKYLGDPLNIIRIFNSKRVDEISIISCENYEKKDINIDFEFLEKISGEAF 76 Query: 74 VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRID 133 P+ GGVRS ED L G ++ + + + +++K E++G+ ++V+ +D + Sbjct: 77 CPLTYSGGVRSLEDADKLFSIGFEKIGIRNLLHTNPEVIKQIAEKYGSQSVVIFIDYK-- 134 Query: 134 EQGNKQVAV----SGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEE 189 E N ++ + + + +++ S+ + ++ G V+ I R+G G ++ + +E Sbjct: 135 ELNNNEIEIYTSYNSFFKSTKSSILEFIKNAESYGAGEVVLQSILREGQSKGLDLDIIKE 194 Query: 190 VCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRAL 228 + + + SS G+ D+ D G GV+ + Sbjct: 195 ITNK-TILPIISSCGMRDLSDARKAFSLGADGVMASKFF 232 >UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C5E2I9_LACTC Length = 550 Score = 48.5 bits (114), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 61/268 (22%), Positives = 110/268 (41%), Gaps = 55/268 (20%) Query: 22 GKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL---VAGVNVPVQV 78 G R+ G P+ Q Y QGA+ + +++T +D + P+++ L V VP+ V Sbjct: 269 GNVRNLGK-PVELAQKYYEQGADEVTFLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTV 327 Query: 79 GGGVRSEEDV-----------AALLEAGVARVVVGSTAVKSQDMVKGWFER--------- 118 GGG++ DV A +G +V +GS AV + + ER Sbjct: 328 GGGIKDIVDVDGTHIPALQVAALYFASGADKVSIGSDAVYAAEKYYELGERGDGASPIET 387 Query: 119 ----FGADALVLALD---VRID----------------EQGNK----QVAVSGWQENSGV 151 +GA A+V+++D V +D E+G Q + G +E+ + Sbjct: 388 ISKSYGAQAVVISVDPKRVYVDGPESVKHKTFETKFPNEKGQTWCWYQCTIKGGRESRDM 447 Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSL--YEEVCARYPQVAFQSSGGIGDID 209 + +L +G VL I +DG+ +G ++ L + + + P +A +G Sbjct: 448 GVWELTRACEALGAGEVLLNCIDKDGSNSGYDLELINHAKEAVKIPVIASSGAGEPKHFK 507 Query: 210 DVAALRGTGVRGVIVGRALLEGKFTVKE 237 + A TG + G++TV + Sbjct: 508 E--AFESTGADACLGAGMFHRGEYTVND 533 >UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms RepID=C1FJN8_9CHLO Length = 601 Score = 48.1 bits (113), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/142 (28%), Positives = 67/142 (47%), Gaps = 33/142 (23%) Query: 23 KQRDYGND------PLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL---VAGVN 73 +++D GND P+ Y QGA+ + +++TG +D P+++ L V Sbjct: 312 REKDDGNDVRNLGKPVELAGKYFKQGADEVAFLNITGYRDLPLTDAPMLEVLRRSSETVF 371 Query: 74 VPVQVGGGVRSEED-----------VAALLEAGVARVVVGSTAV----------KSQD-- 110 VP+ VGGG+R D AA +AG +V +GS AV K +D Sbjct: 372 VPLTVGGGIRDFTDSNGVSYTALEVAAAYFKAGADKVSIGSDAVYVAEQYYANDKKKDGC 431 Query: 111 -MVKGWFERFGADALVLALDVR 131 ++ ER+G A+V+++D R Sbjct: 432 TSIEQISERYGVQAMVVSIDPR 453 >UniRef50_B1LZS6 Histidine biosynthesis protein n=10 Tax=Alphaproteobacteria RepID=B1LZS6_METRJ Length = 243 Score = 47.8 bits (112), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 86/195 (44%), Gaps = 26/195 (13%) Query: 43 AEVLHLVDLTGAKD---PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARV 99 A +L++ DL D P R + I GV++ V G V A L +G+ R Sbjct: 64 AAILYVADLDAIIDRAAPDLRALEAIARACPGVSL--WVDAGFAEPAAVDAFLASGLGRP 121 Query: 100 VVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVET 159 V+GS + D+V R G D V +LD R G +++ + ++ + Sbjct: 122 VIGSESQADADLVT----RLG-DRAVFSLDTR----GAERLGPAALHDDPAL-------- 164 Query: 160 YLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGV 219 + P V+ +++ G AG ++ + AR P ++GG+ DD+ ALR G+ Sbjct: 165 WPP----EVIAMTLAQVGAGAGPDLGALGALRARAPDRRLYAAGGVRGPDDLRALRAAGI 220 Query: 220 RGVIVGRALLEGKFT 234 G +V AL +G + Sbjct: 221 AGALVASALHDGTLS 235 >UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9303 RepID=A2CB98_PROM3 Length = 266 Score = 47.4 bits (111), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 19/91 (20%), Positives = 54/91 (59%) Query: 46 LHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTA 105 L ++D++ K ++R ++K L + +P+ GGG+ S + L ++G ++++ ++ Sbjct: 52 LLVIDVSRKKRNSQRFCSMLKKLSSDCFLPIGAGGGLDSLDKAKMLFDSGADKLILNTSV 111 Query: 106 VKSQDMVKGWFERFGADALVLALDVRIDEQG 136 ++ +++K + +G A++ ++D++ +E G Sbjct: 112 YENPELIKALNKFYGQQAIIASVDIKKNELG 142 >UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=O26765_METTH Length = 227 Score = 47.4 bits (111), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 65/241 (26%), Positives = 106/241 (43%), Gaps = 33/241 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN------DPLPRLQDYAAQGAEVLHLVDL---- 51 IIP +DL+DG V G+ K R + DP+ A GA +++ DL Sbjct: 4 IIPVIDLMDGIAVSGKSGEREKYRPLESVYSPSPDPVNIALSLRAAGARSIYIADLDAIE 63 Query: 52 -TGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 TG+ A R++ + +PV + GVR E +LE +RVVV + ++S + Sbjct: 64 GTGSNLEAVRRVNHV--------LPVILDAGVRDLETFHFMLEFA-SRVVVATETLESTE 114 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 ++ + + V+++DV+ + N + LE+L + + + +L Sbjct: 115 ELEEILRNYPPERTVVSVDVK---------DMRLHSRNLEIGLEELRDLLMGYEVDIILL 165 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 DI GT +G N L E P + GG +++ L GVR +VGRAL E Sbjct: 166 -DIGSVGTSSGFNRELLELF---RPLIERVIPGGGVLPEEIPELEAMGVRAALVGRALHE 221 Query: 231 G 231 G Sbjct: 222 G 222 >UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SPR8_NEMVE Length = 545 Score = 47.4 bits (111), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 62/277 (22%), Positives = 108/277 (38%), Gaps = 64/277 (23%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL---VAGVNVPVQVGGGVR--- 83 DP+ + + + GA+ + +++T + + ++K L + VP VGGG+R Sbjct: 264 DPVELGERFFSDGADEIAFLNITSFRSSPIHDLAMLKLLRKCCERIFVPFTVGGGIRDIY 323 Query: 84 -----------------SEEDVAAL-LEAGVARVVVGSTAVKS-------------QDMV 112 S +VAA+ ++G +V V S AV + + + Sbjct: 324 ALDPDSVEEGKPVMRQFSALEVAAMYFKSGADKVSVASDAVYAAEEFIASGHKKTGKTSI 383 Query: 113 KGWFERFGADALVLALDVRI-------------------DEQGNK----QVAVSGWQENS 149 + ER+G A+VLA+D + G K Q V G +E Sbjct: 384 EKIAERYGRQAVVLAVDTKTVYVPSPDSTKHHTVKARYPGPNGEKYVWWQCTVKGGRETR 443 Query: 150 GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEV--CARYPQVAFQSSGGIGD 207 V +LV+ +G +L +I RDGT G ++ L + V P +A +G + D Sbjct: 444 DVGAYELVKACEELGAGEILLNNIDRDGTNHGYDLDLVKMVKGAVSIPVIASSGAGHVSD 503 Query: 208 IDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 D+ R T G + G G+ + + +N Sbjct: 504 FVDL--FRETNADGAMAGAIFHRGEVDITDVKEHLRN 538 >UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oceani RepID=Q3JEF8_NITOC Length = 235 Score = 46.6 bits (109), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 60/261 (22%), Positives = 98/261 (37%), Gaps = 58/261 (22%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEV--------------LH 47 ++P LDL G VV G QRD LP +A + + L+ Sbjct: 3 LLPVLDLWGGVVVHAR----GGQRD---SYLPLNSPFAPNSSPLQVVAGLLQWCRFQQLY 55 Query: 48 LVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVK 107 + DL + + ++ + V GG E VA L GVAR VVG+ + Sbjct: 56 IADLNAIMGDGNNHFMIAAIARSYPDLELWVDGGTARHEAVAQLFALGVARPVVGTETLP 115 Query: 108 SQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYL-PVGLK 166 ++ W Q S W E +S++ +L P GL Sbjct: 116 D---LESW-----------------------QALQSSWPEQLALSMDHRRGAFLGPAGLD 149 Query: 167 H--------VLCTDISRDGTLAGSNVSLYEEVCARY--PQVAFQSSGGIGDIDDVAALRG 216 V+ + + G+ G + SL E + R +++ ++GG+ ++D+ L Sbjct: 150 RQPELWPGTVIAMSLDQIGSQQGPDWSLLERLGQRSLRKRISLLAAGGVRCLEDLKQLAA 209 Query: 217 TGVRGVIVGRALLEGKFTVKE 237 GV GV++ AL +G E Sbjct: 210 WGVEGVLLASALHDGSLNPAE 230 >UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hisF n=360 Tax=Bacteria RepID=HIS6_XANOM Length = 258 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 51/216 (23%), Positives = 96/216 (44%), Gaps = 10/216 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ + + D G D + Y AQGA+ L D+ + + Sbjct: 6 IIPCLDVRNGRVVKGVK--FHDHIDMG-DIVELALRYRAQGADELVFYDIGASPEGRSVD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ + +++P V GG+ E A+L AG ++ + S A+ ++ + FG Sbjct: 63 YTWVERVARLIDIPFCVAGGIGDVETARAVLHAGADKISINSPALGRPQLISELADAFGV 122 Query: 122 DALVLALDVRIDEQGNKQVA-----VSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +V+ +D ++ G +V S Q +L+ + E +G ++ + D Sbjct: 123 QCVVVGIDSIREDDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQR-LGAGEIVLNCMDND 181 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA 212 G G +++ +V A V +SGG G++ A Sbjct: 182 GVRRGYDIAQLRQVRA-LCHVPLIASGGAGEMQHFA 216 >UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepID=Q4JIN2_9BACT Length = 248 Score = 45.4 bits (106), Expect = 0.002, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 106/244 (43%), Gaps = 22/244 (9%) Query: 2 IIPALDLIDGTVVRLHQG---DYGKQRDYG------NDPLPRLQDY-AAQGAEVLHLVDL 51 +I +DL G V G DY R G DP + Y +G L++ DL Sbjct: 3 VIGVIDLAAGRAVHARGGRRTDYAPVRLSGAAAAHVGDPCALARTYLETRGLTELYVADL 62 Query: 52 TGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM 111 A Q I L+ + P+ + GV S L G + VVVG + S D+ Sbjct: 63 D-AIGGGPSQDAAIGALIR-LGAPLWLDSGVHSVPRARHALGLGASFVVVGLETLPSYDV 120 Query: 112 VKGWFERFGADALVLALDVR--IDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVL 169 + G++ + +LD+R + + VA +G S+EQ+ + G+ ++ Sbjct: 121 LSEICADVGSERVAFSLDLRDGLPITAHADVA-------AGRSVEQIAARAVEAGVGAII 173 Query: 170 CTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 D++R G G +++L + + P V + GG+ +D+A+L G GV+V AL Sbjct: 174 VIDVARVGMGEGVDLALISSLRSVAPAV-LLAGGGVRGSEDLASLAHAGCDGVLVATALH 232 Query: 230 EGKF 233 +G+ Sbjct: 233 DGRI 236 >UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6XVQ0_PEDHD Length = 288 Score = 45.4 bits (106), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/220 (19%), Positives = 91/220 (41%), Gaps = 19/220 (8%) Query: 42 GAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVV 101 G + + L D++ + + +I+ VP+ VGGG+ + + LL G ++ + Sbjct: 43 GIDEIILTDISATRKQSGPDFDMIRRAAQKCFVPLTVGGGISNTGQMKELLHNGADKISL 102 Query: 102 GSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSG--VSLEQLVET 159 + A+ + +++ FG +V+++D NK + + +S +S + + Sbjct: 103 NNAAITTPELITETAHIFGGQCVVISID---GIHTNKGFRIYDYLTHSALDISPSEFAKR 159 Query: 160 YLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCA--RYPQVAFQSSGGIGDIDDVAA---- 213 G +L + RDG+ G + L VC+ P + + GD +V + Sbjct: 160 AEDSGAGEILINSVDRDGSYLGFDHELINSVCSVVNIPVIVCGGAKNAGDFIEVFSKTNA 219 Query: 214 -------LRGTGVRGVIVGRALLEGKFTVK-EAIACWQNA 245 V + +++L K V+ EA A +++A Sbjct: 220 SAATAANFFHFSEHSVNITKSILNKKMDVRSEAFANYEDA 259 >UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_YEAST Length = 552 Score = 45.1 bits (105), Expect = 0.002, Method: Compositional matrix adjust. Identities = 58/259 (22%), Positives = 108/259 (41%), Gaps = 54/259 (20%) Query: 31 PLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL---VAGVNVPVQVGGGVRSEED 87 P+ Q Y QGA+ + +++T +D + P+++ L V VP+ VGGG++ D Sbjct: 279 PVQLAQKYYQQGADEVTFLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVD 338 Query: 88 V-----------AALLEAGVARVVVGSTAVKSQDMVKGWFER-------------FGADA 123 V + +G +V +G+ AV + + R +GA A Sbjct: 339 VDGTKIPALEVASLYFRSGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQA 398 Query: 124 LVLALD---VRIDEQG---NK-----------------QVAVSGWQENSGVSLEQLVETY 160 +V+++D V ++ Q NK Q + G +E+ + + +L Sbjct: 399 VVISVDPKRVYVNSQADTKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRAC 458 Query: 161 LPVGLKHVLCTDISRDGTLAGSNVSLYEEV--CARYPQVAFQSSGGIGDIDDVAALRGTG 218 +G +L I +DG+ +G ++ L E V + P +A S G+ + + A L+ T Sbjct: 459 EALGAGEILLNCIDKDGSNSGYDLELIEHVKDAVKIPVIA-SSGAGVPEHFEEAFLK-TR 516 Query: 219 VRGVIVGRALLEGKFTVKE 237 + G+FTV + Sbjct: 517 ADACLGAGMFHRGEFTVND 535 >UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9301 RepID=A3PE78_PROM0 Length = 222 Score = 43.5 bits (101), Expect = 0.007, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 78/179 (43%), Gaps = 19/179 (10%) Query: 65 IKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADAL 124 I L++ +P+ +GG +RS E+ L G ++++ + Q+++K + +G ++ Sbjct: 39 ISLLLSKTFLPITIGGKIRSIENAKELFNFGADKILISRAFFQDQNLLKEIRDLYGVQSI 98 Query: 125 VLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLK-HVLCTDISRDGTLAGSN 183 V+ D+ N + ++ E +L+++V + L ++ I RDGT G N Sbjct: 99 VVQFDIN---SQNYDIFINSSLEKVS-NLKKIVYSLNEKNLMGELIINQIDRDGTGFGHN 154 Query: 184 VSLYEEVCA-RYPQVAFQSSGGIGD---------IDDVAALRGTGVRGVIVGRALLEGK 232 + P +A SGG G D ++A+ + + I G A E + Sbjct: 155 TEYLNAIPKLNMPLIA---SGGFGSSIHMAECLKFDSISAVATSNLLNFI-GDAFSEAR 209 >UniRef50_A3HVC3 PcrB-like protein n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVC3_9SPHI Length = 259 Score = 42.7 bits (99), Expect = 0.010, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 39/72 (54%), Gaps = 8/72 (11%) Query: 52 TGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM 111 +GA+ P Q+ I+TL ++ P+ +GGG+ S+E V EAG VV+G++ K D Sbjct: 184 SGAQKPVSSQV--IETLSKAISCPLIIGGGIDSQEKVREAYEAGADLVVLGNSIEKDPDF 241 Query: 112 V------KGWFE 117 + K W+ Sbjct: 242 LAEVLNFKAWYN 253 >UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hisF n=2 Tax=Bacteria RepID=C9YDK8_9BURK Length = 286 Score = 42.7 bits (99), Expect = 0.012, Method: Compositional matrix adjust. Identities = 37/152 (24%), Positives = 60/152 (39%) Query: 32 LPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAAL 91 LP ++ Y + + L LVD+ + I VP+ VGGG+ E V L Sbjct: 59 LPAIKVYNQREVDELVLVDILAHGRGEEPDYESIHEFGQDCFVPLTVGGGITHIEQVQRL 118 Query: 92 LEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGV 151 L G +V + + A ++V R G +V ++DVR G + +G Sbjct: 119 LRVGADKVSLNTAAYARPELVSDIARRHGVQCVVASIDVRPRAGGGWDCFSHAGTQPTGR 178 Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 + G +L T I DG++ G + Sbjct: 179 DVVAWARELEDRGAGEILVTSIDLDGSMRGYD 210 >UniRef50_B8EIK2 Histidine biosynthesis protein n=2 Tax=Beijerinckiaceae RepID=B8EIK2_METSB Length = 237 Score = 42.4 bits (98), Expect = 0.014, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 101/246 (41%), Gaps = 32/246 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP +DL DG VVR G +R++ RL +A G V L+ L Sbjct: 3 VIPVIDLKDGAVVRARLG----RREFYAPIESRLAATSAPGDIVAGLLSLH--------- 49 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTA-VKSQDMVKGWFERFG 120 P +A +N G EDV LE +V A VK + W R Sbjct: 50 -PFATIYIADLNAIDARG----DHEDVLFSLEEAFPQVEFWVDAGVKDAGEARSWLLRHK 104 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYL-PVGL--------KHVLCT 171 LVL + + + + +E +SL+ ET++ P L V+ Sbjct: 105 RAILVLGTETL---GSSATLEILKDEERIILSLDFRGETFIGPEALLSAQHIWPSRVIAM 161 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 + R G AG ++S V A + + ++GG+ +D+AAL GV G +V AL +G Sbjct: 162 TLGRIGANAGPDLSRIASVKALSDRKVY-AAGGVRGTEDLAALDRAGVDGALVASALHDG 220 Query: 232 KFTVKE 237 + T +E Sbjct: 221 QLTSQE 226 >UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TGW8_METVO Length = 181 Score = 42.4 bits (98), Expect = 0.016, Method: Compositional matrix adjust. Identities = 30/135 (22%), Positives = 64/135 (47%), Gaps = 4/135 (2%) Query: 79 GGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNK 138 GGG+++ E+ + + E G ++ + S + ++ + +G+ ++V ++DV+ + G Sbjct: 12 GGGIKTFEEASKIFELGFEKISLNSVLFEKPSLLTELSQSYGSQSIVASVDVKKNLFGKL 71 Query: 139 QVAVSGWQENS-GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCA--RYP 195 +V +G + NS + V+ +G +L + +GT G N+SL E+ P Sbjct: 72 KV-YNGSKNNSINDKILDYVKNLENLGAGELLINSVDLEGTYKGYNLSLINELSNALTIP 130 Query: 196 QVAFQSSGGIGDIDD 210 +A + D D Sbjct: 131 LIALGGASSTKDFKD 145 >UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C0W3_9PLAN Length = 247 Score = 42.0 bits (97), Expect = 0.018, Method: Compositional matrix adjust. Identities = 62/252 (24%), Positives = 107/252 (42%), Gaps = 36/252 (14%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY---------GNDPL---PRLQDYAAQGAEVLHLV 49 IIP LD+++ T+VR G G++ Y + PL LQD G ++ Sbjct: 3 IIPVLDILNQTIVR---GIAGQRETYQPIQSGLTHSSQPLDIAQALQDEF--GFSEFYVA 57 Query: 50 DLTGAKDPAKRQIPLIKTLV-AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKS 108 DL A + + + + L+ AG + G + D L + +V G ++S Sbjct: 58 DLD-AILQQRLNLQMYQCLLDAGFTFLLDCG--LHFAGDSQPLSKMKGITIVAGLETLES 114 Query: 109 QDMVKGWFERFGADALVLALD------VRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP 162 +K + +GA + V +LD VR N A+ E + +SL+Q Sbjct: 115 PQELKQLVQNWGAASTVFSLDLKQGKPVRNSSSDNPYAAIDDPLEIAELSLQQ------- 167 Query: 163 VGLKHVLCTDISRDGTLAGSNV-SLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRG 221 G+ ++ D++ GT G+ +L + + +P + + GGI IDD+ G Sbjct: 168 -GVNQMILLDLANVGTGQGTGTEALCRTLRSHHPDLRLITGGGIHSIDDLQTQAEQGADA 226 Query: 222 VIVGRALLEGKF 233 V+V AL +G+ Sbjct: 227 VLVASALHDGRL 238 >UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit HisF2 n=3 Tax=Rhizobium RepID=Q7WYR2_RHIL3 Length = 251 Score = 42.0 bits (97), Expect = 0.018, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 95/210 (45%), Gaps = 14/210 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L+D + ++G +R Y DP ++ + + + + ++D+ + Sbjct: 5 LIPVL-LVDQKRRLVKTIEFG-ERTYVGDPFNVVRLFNEKEVDEICILDIDATRTGRGPD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ L +P+ GGG+ + L +GV + V+G A SQ +V G+ Sbjct: 63 LGFVRELATECFMPLAYGGGITELKQCEELNRSGVEKFVLGQGARNSQ-LVGAIAADMGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPV---GLKHVLCTDISRDGT 178 ALV +DV D +G A + +SG E +E L + G+ ++ + DGT Sbjct: 122 QALVACVDV--DGRG----AAASCYASSGARQEP-IEFCLRLQDAGVGEIILQSKTLDGT 174 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDI 208 G ++ L + + R + + GG GD+ Sbjct: 175 RNGYDLELIQSI-TRKLSIPVVALGGAGDV 203 >UniRef50_Q2RGX5 Ferredoxin-dependent glutamate synthase n=2 Tax=Clostridia RepID=Q2RGX5_MOOTA Length = 472 Score = 40.0 bits (92), Expect = 0.063, Method: Compositional matrix adjust. Identities = 32/96 (33%), Positives = 44/96 (45%), Gaps = 6/96 (6%) Query: 19 GDYGKQRDYGNDPLP--RLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLI---KTLVAGVN 73 G G +YG P RL A V H + G KDP K PL+ + L GV Sbjct: 216 GGLGHSTNYGEIPTKGRRLLGIKPGQAAVTH-ARMPGIKDPKKDLPPLVTRLRHLTGGVP 274 Query: 74 VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQ 109 + ++G G E+D+A LLEAGV + + S+ Sbjct: 275 IGAKIGAGNDLEKDLAILLEAGVDFIAIDGAGAASK 310 >UniRef50_O82782 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic n=33 Tax=cellular organisms RepID=HIS4_ARATH Length = 304 Score = 40.0 bits (92), Expect = 0.075, Method: Compositional matrix adjust. Identities = 46/177 (25%), Positives = 76/177 (42%), Gaps = 12/177 (6%) Query: 76 VQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM----VKGWFERFGADALVLALDVR 131 +QVGGG+ S E+ + +E G + V+V S + + +K G L+L L R Sbjct: 126 LQVGGGINS-ENCMSYIEEGASHVIVTSYVFNNGKIDLERLKDIVSIVGKQRLILDLSCR 184 Query: 132 IDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVC 191 + G + WQ+ S V L++ +L L + +G G + L + Sbjct: 185 -KKDGRYAIVTDRWQKFSDVILDEKSLEFLGGFSDEFLVHGVDVEGKKLGIDEELV-ALL 242 Query: 192 ARYPQVAFQSSGGIGDIDDVAALR--GTGVRGVIVGRAL--LEGKFTVKEAIACWQN 244 Y + +GG+ +DDV ++ G G V VG AL G K+ +A W + Sbjct: 243 GNYSPIPVTYAGGVTVMDDVERIKDAGKGRVDVTVGSALDIFGGNLPYKDVVA-WHH 298 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 316 3e-85 UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 301 9e-81 UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 296 5e-79 UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 294 2e-78 UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 284 2e-75 UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 283 5e-75 UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 281 1e-74 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 280 2e-74 UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 279 5e-74 UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 278 1e-73 UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 278 1e-73 UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 277 2e-73 UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 276 5e-73 UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 273 4e-72 UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 273 5e-72 UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 272 6e-72 UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 271 2e-71 UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 269 4e-71 UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 269 4e-71 UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 268 8e-71 UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 268 1e-70 UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 267 2e-70 UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 267 3e-70 UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 266 5e-70 UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 266 6e-70 UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 264 1e-69 UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 264 2e-69 UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 263 3e-69 UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 263 4e-69 UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 263 5e-69 UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 262 7e-69 UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 262 7e-69 UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 262 9e-69 UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 262 9e-69 UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 262 9e-69 UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 260 2e-68 UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 260 3e-68 UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 259 5e-68 UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 259 5e-68 UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxa... 259 6e-68 UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 259 6e-68 UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 259 6e-68 UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 259 6e-68 UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 258 1e-67 UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 258 1e-67 UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 258 2e-67 UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 258 2e-67 UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 3e-67 UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 256 3e-67 UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=... 256 5e-67 UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 256 5e-67 UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 255 7e-67 UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxa... 255 1e-66 UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 255 1e-66 UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 1e-66 UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 1e-66 UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 1e-66 UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 2e-66 UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 2e-66 UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 3e-66 UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 253 4e-66 UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 253 5e-66 UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 253 5e-66 UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 253 6e-66 UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 252 7e-66 UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 251 1e-65 UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 250 4e-65 UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole ... 249 4e-65 UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 248 2e-64 UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 248 2e-64 UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 247 2e-64 UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 247 2e-64 UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 247 3e-64 UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 247 3e-64 UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hi... 246 6e-64 UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 246 7e-64 UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 245 7e-64 UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 245 1e-63 UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 245 1e-63 UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxa... 245 1e-63 UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hi... 244 2e-63 UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 244 3e-63 UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 243 4e-63 UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 6e-63 UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 6e-63 UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hi... 242 1e-62 UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 241 2e-62 UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 240 2e-62 UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 3e-62 UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 4e-62 UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomyc... 239 4e-62 UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxa... 239 5e-62 UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 6e-62 UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 6e-62 UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxa... 239 7e-62 UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 8e-62 UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hi... 239 9e-62 UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 1e-61 UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 1e-61 UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole... 237 3e-61 UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 4e-61 UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 235 8e-61 UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 235 9e-61 UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hi... 234 3e-60 UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 3e-60 UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 3e-60 UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 4e-60 UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hi... 232 1e-59 UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 228 1e-58 UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 228 1e-58 UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hi... 227 2e-58 UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 227 2e-58 UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hi... 227 2e-58 UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 227 3e-58 UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hi... 226 6e-58 UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 225 1e-57 UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 3e-57 UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hi... 223 4e-57 UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spir... 223 4e-57 UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hi... 222 9e-57 UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanae... 222 1e-56 UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 3e-56 UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hi... 219 9e-56 UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 1e-55 UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 218 2e-55 UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hi... 217 2e-55 UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collins... 216 6e-55 UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 7e-55 UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hi... 214 3e-54 UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 3e-54 UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hi... 213 5e-54 UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase su... 212 5e-54 UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hi... 212 7e-54 UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winog... 212 9e-54 UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hah... 212 1e-53 UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfati... 212 1e-53 UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hi... 212 1e-53 UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hi... 211 2e-53 UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hi... 211 2e-53 UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 210 3e-53 UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococ... 209 5e-53 UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazol... 209 7e-53 UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Pro... 208 1e-52 UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase su... 207 2e-52 UniRef50_P72139 Putative imidazole glycerol phosphate synthase s... 207 3e-52 UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovi... 207 3e-52 UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillon... 206 6e-52 UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Pro... 206 7e-52 UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hi... 205 9e-52 UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hi... 205 9e-52 UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hi... 204 3e-51 UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, c... 203 4e-51 UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hi... 202 9e-51 UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 200 4e-50 UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 198 1e-49 UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter... 198 1e-49 UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase s... 198 1e-49 UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picr... 198 2e-49 UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hi... 197 4e-49 UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria ... 197 4e-49 UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosyl... 196 4e-49 UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 196 6e-49 UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase s... 196 6e-49 UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hi... 196 7e-49 UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase s... 195 1e-48 UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanae... 194 2e-48 UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter... 194 2e-48 UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 192 1e-47 UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hi... 191 1e-47 UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase s... 191 2e-47 UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Pr... 191 2e-47 UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 191 2e-47 UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxa... 189 1e-46 UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3... 189 1e-46 UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 188 2e-46 UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 187 3e-46 UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase su... 181 1e-44 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 181 2e-44 UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase s... 181 3e-44 UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 179 6e-44 UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii H... 179 7e-44 UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase su... 177 2e-43 UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase su... 176 8e-43 UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobact... 175 1e-42 UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxa... 174 2e-42 UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 172 7e-42 UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit Hi... 172 1e-41 UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovi... 171 2e-41 UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID... 170 3e-41 UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 170 4e-41 UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 169 9e-41 UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicr... 169 9e-41 UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 169 1e-40 UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirg... 165 8e-40 UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacte... 164 2e-39 UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis... 163 4e-39 UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlo... 160 5e-38 UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C... 159 9e-38 UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase s... 158 1e-37 UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 157 4e-37 UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_Y... 157 4e-37 UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Me... 156 6e-37 UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methano... 154 3e-36 UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase su... 154 3e-36 UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxa... 152 1e-35 UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanoco... 149 7e-35 UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepI... 147 2e-34 UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 147 3e-34 UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms Re... 145 1e-33 UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxa... 143 4e-33 UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase s... 143 6e-33 UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methano... 140 3e-32 UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxa... 139 7e-32 UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase Hi... 139 7e-32 UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 T... 139 9e-32 UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oce... 137 3e-31 UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlo... 135 2e-30 UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlo... 134 3e-30 UniRef50_B1LZS6 Histidine biosynthesis protein n=10 Tax=Alphapro... 110 6e-23 UniRef50_D2MIW0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 100 7e-20 Sequences not found previously or not previously below threshold: UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hi... 173 6e-42 UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine... 155 1e-36 UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes:... 149 6e-35 UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. ... 149 7e-35 UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n... 144 2e-33 UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=La... 139 8e-32 UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit H... 139 1e-31 UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogen... 134 4e-30 UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malasse... 131 2e-29 UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales... 124 3e-27 UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanoco... 121 2e-26 UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococ... 120 5e-26 UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole ... 120 6e-26 UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanoco... 119 1e-25 UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planc... 106 6e-22 UniRef50_C0N3H2 Histidine biosynthesis protein n=1 Tax=Methyloph... 106 7e-22 UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobial... 105 1e-21 UniRef50_Q1H0R8 Histidine biosynthesis n=1 Tax=Methylobacillus f... 103 6e-21 UniRef50_Q603E0 Putative HisA/HisF family protein n=1 Tax=Methyl... 100 4e-20 UniRef50_A2SJ37 HisA/HisF family protein, putative n=3 Tax=Burkh... 100 7e-20 UniRef50_Q6R3H4 Conserved protein n=1 Tax=Methylosinus sp. LW2 R... 99 9e-20 UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlo... 99 1e-19 UniRef50_D1JF95 Putative phosphoribosylformimino-5-aminoimidazol... 99 1e-19 UniRef50_C6XDW4 Histidine biosynthesis protein n=1 Tax=Methylovo... 96 8e-19 UniRef50_Q0G4J3 HisA/HisF family protein, putative n=1 Tax=Fulvi... 96 9e-19 UniRef50_A7IL67 Histidine biosynthesis protein n=2 Tax=Alphaprot... 95 1e-18 >UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=97 Tax=Gammaproteobacteria RepID=HIS4_YERP3 Length = 245 Score = 316 bits (812), Expect = 3e-85, Method: Composition-based stats. Identities = 194/244 (79%), Positives = 221/244 (90%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALDLI+G VVRLHQGDYG+QRDYGN PLPRLQDY QGA+VLHLVDLTGAKDPA R Sbjct: 1 MIIPALDLIEGKVVRLHQGDYGQQRDYGNHPLPRLQDYQQQGAQVLHLVDLTGAKDPAAR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 QIPL++ L+AGV+VPVQVGGG+R+E+DV ALLEAG ARVVVGSTAVK +MV+ WFER+G Sbjct: 61 QIPLLRELLAGVDVPVQVGGGIRNEQDVVALLEAGAARVVVGSTAVKQPEMVQQWFERYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+A+VLALDVRI+E G K VA+SGWQENS +LEQ+VE YLP GLKHVLCTDISRDGTL+ Sbjct: 121 AEAIVLALDVRINEAGCKHVAISGWQENSDATLEQIVEQYLPYGLKHVLCTDISRDGTLS 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 GSNV LY+EVC RYPQVAFQ+SGGIG +DD+A LRG+GV+GVIVGRALL+GKF VKEAIA Sbjct: 181 GSNVELYQEVCQRYPQVAFQASGGIGCLDDIARLRGSGVQGVIVGRALLDGKFNVKEAIA 240 Query: 241 CWQN 244 CWQN Sbjct: 241 CWQN 244 >UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=92 Tax=Proteobacteria RepID=HIS4_ACTP2 Length = 250 Score = 301 bits (773), Expect = 9e-81, Method: Composition-based stats. Identities = 169/244 (69%), Positives = 199/244 (81%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPALDLIDG VVRLHQGDY KQ Y ++P+ + +Y AQGAE LHLVDLTGAK PAKR Sbjct: 6 IIIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFANYLAQGAEQLHLVDLTGAKYPAKR 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI ++A N +QVGGG+R+E+DVA LL G RVV+GSTAVK + MVKGWFE++G Sbjct: 66 QTALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYG 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ VLALDV ID G K +A+SGWQE SGVSLE+L+E Y VGL+HVLCTDISRDGTLA Sbjct: 126 AEKFVLALDVNIDASGQKIIAISGWQEASGVSLEELIEDYQVVGLQHVLCTDISRDGTLA 185 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 GSNV+LY E+CA+YP++ FQSSGGIG +DD+ AL+GTGV GVIVGRALLEGKF V EAI Sbjct: 186 GSNVNLYREICAKYPKIHFQSSGGIGSLDDIKALKGTGVSGVIVGRALLEGKFNVAEAIE 245 Query: 241 CWQN 244 CWQN Sbjct: 246 CWQN 249 >UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Alteromonadales RepID=HIS4_COLP3 Length = 261 Score = 296 bits (758), Expect = 5e-79, Method: Composition-based stats. Identities = 137/242 (56%), Positives = 178/242 (73%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IPA+DLI G VVRL+QGDY ++ +Y R Q YA GA V+H VDL GAKD KR Sbjct: 1 MMIPAIDLIGGEVVRLYQGDYAQKTNYQYTVQDRQQAYAESGATVMHFVDLDGAKDSTKR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ +KT+V ++ +QVGGGVR E+DV LL G RVV+GS A+K ++V W + +G Sbjct: 61 QLKTLKTVVNHPSMIIQVGGGVRCEDDVKQLLALGADRVVIGSLAIKQPELVTQWVKTYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VLALD++ID QGNK + GW E+SGV+LE L+ Y G+KHVLCTDIS+DGTL Sbjct: 121 CEKIVLALDIKIDAQGNKTLPTHGWIEDSGVNLEDLLAQYQDAGIKHVLCTDISKDGTLT 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+NV LY EVCA+YP + +Q+SGGIG + D+ AL TGV GVI+GR+LLEGKFT++EAIA Sbjct: 181 GTNVDLYSEVCAKYPDIDWQASGGIGSLADIKALIPTGVSGVILGRSLLEGKFTLEEAIA 240 Query: 241 CW 242 CW Sbjct: 241 CW 242 >UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_FRAP2 Length = 241 Score = 294 bits (753), Expect = 2e-78, Method: Composition-based stats. Identities = 111/240 (46%), Positives = 155/240 (64%), Gaps = 1/240 (0%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DLI+G VRL +GD+ K Y +P + Y GAE +H+VDL GAK Q Sbjct: 3 IFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQTCQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ + N+ +QVGGGV+ E + LLE GV RVV+GS AVK + K +FE++GA Sbjct: 63 FETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKYGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +VLALDV + G +A GWQE+S +L+++++TYL GL++VLCTDISRDG L G Sbjct: 123 EKIVLALDV-FIKNGVPYIATHGWQESSTTTLDEILQTYLGDGLEYVLCTDISRDGMLQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N LY + YP V F +SGG+G ++D+ L+ GVI+G+AL E KFT++EA+ C Sbjct: 182 PNFELYRIYSSIYPDVQFMASGGVGSLEDLEILKEQNTYGVIIGKALYENKFTLQEALEC 241 >UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=15 Tax=root RepID=HIS4_DEHSC Length = 244 Score = 284 bits (728), Expect = 2e-75, Method: Composition-based stats. Identities = 88/241 (36%), Positives = 137/241 (56%), Gaps = 7/241 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++ G VRL QGDY ++ Y +DP+ + + GA LH+VDL GA D Sbjct: 10 IIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQSVN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LIK + +PV+VGGG+RS E V LL AGV RV++G+ AV++ ++VK R+ A Sbjct: 70 FELIKEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICARY-A 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D++ +++D R N +VA GW N+ + +L + +G++ + TDISRDGTL+ Sbjct: 129 DSVAVSIDAR-----NGKVATRGWVTNTEIDALELARSMKKLGIRRFIYTDISRDGTLSE 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + ++ + V +SGG+ + + L+ G G IVG+A+ G +K A Sbjct: 184 PNFAAIRDLISAI-NVPVIASGGVSSLSHLRLLKDIGAEGAIVGKAIYTGDLNLKRAFED 242 Query: 242 W 242 Sbjct: 243 L 243 Score = 45.4 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 24/96 (25%), Positives = 39/96 (40%), Gaps = 5/96 (5%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAG--SNVSLYEEVCARYPQVAFQSSGGIGDID 209 + +G + + DG G N L +E+ A + + GGI ++ Sbjct: 38 DPVGTAMRWQSLGAPRLHV--VDLDGAADGQSVNFELIKEI-ANSALIPVEVGGGIRSME 94 Query: 210 DVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA 245 V L GV VI+G A +E VKE A + ++ Sbjct: 95 TVKKLLVAGVDRVILGTAAVENPELVKEICARYADS 130 >UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Salinibacter ruber DSM 13855 RepID=HIS4_SALRD Length = 258 Score = 283 bits (724), Expect = 5e-75, Method: Composition-based stats. Identities = 88/247 (35%), Positives = 143/247 (57%), Gaps = 9/247 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ DG VRLHQGDY + Y DP+ + + Q A+ LH+VDL A+ + Sbjct: 3 LVIPAIDIRDGRCVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEH 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + +++P+Q+GGG+RS + + A L+ GV RV++G+ AV++ D V+ E+F Sbjct: 63 NRDVIGKMCDALDIPIQLGGGIRSMDQIEAALDRGVYRVILGTAAVRNPDFVERAVEQFS 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A +V+++D R + +V V GW E SG+ + G++ ++ TDISRDGT+ Sbjct: 123 ARRVVVSIDAR-----DGEVRVQGWTEGSGLDAVAFAKDMEQRGVRRLVYTDISRDGTMD 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDID---DVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N+ Y + + +SGG+G+ D D+ L+ GV VIVG AL E +F ++ Sbjct: 178 GPNIQAYRTLGRQLAHAKVTASGGVGEHDDLLDIQTLQPYGVDSVIVGTALYENRFPCQQ 237 Query: 238 AIACWQN 244 WQ+ Sbjct: 238 -FWAWQD 243 >UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Bacteria RepID=HIS4_LISW6 Length = 240 Score = 281 bits (721), Expect = 1e-74, Method: Composition-based stats. Identities = 84/244 (34%), Positives = 134/244 (54%), Gaps = 7/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL +G VRL QGD+ K+ DP+ + + +A GA LH+VDL GA + Sbjct: 3 IFPAIDLKNGQCVRLFQGDFSKKMIVNEDPIAQAKAFATGGATYLHIVDLDGALEGRPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + VPVQVGGG+RS V L++G+ RV++GS A+ + D + +++G Sbjct: 63 LEIIQKMKEAATVPVQVGGGIRSLAQVDYYLDSGIDRVIIGSAALTNPDFLHAAVQKYGP 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + N VA SGW E S V+ L + VG++ ++ TDISRDGTL G Sbjct: 123 -KIAVGIDAK-----NGYVATSGWLEVSQVNYLDLAKQMEKVGVETIIYTDISRDGTLTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N+ + ++ + +SGG+ D+ AL G+ G I G+AL G ++ + Sbjct: 177 PNLEQMAAL-QKHVNIHLIASGGVSSRADLEALSQLGLYGAIAGKALYNGHISMSDVTEV 235 Query: 242 WQNA 245 +A Sbjct: 236 ENHA 239 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 280 bits (718), Expect = 2e-74, Method: Composition-based stats. Identities = 80/243 (32%), Positives = 141/243 (58%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ DG VRL +G + + Y P + + GA+ +H VDL GA Sbjct: 3 LYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + + VNVPVQ+GGG+R+ E++ +L+ GV RV++G+ AV++ D +K +RFGA Sbjct: 63 AETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V+ +D + + VA+ GW++ S + L +G++ ++ TDIS+DG LAG Sbjct: 123 EHIVVGVDAK-----DGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDISKDGMLAG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV ++ + + +SGG+ +DD+ + G+ G I+G+A+ E + +KEA+ Sbjct: 178 PNVEQT-KILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNL 236 Query: 242 WQN 244 +++ Sbjct: 237 FES 239 >UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Halothermothrix orenii H 168 RepID=HIS4_HALOH Length = 237 Score = 279 bits (715), Expect = 5e-74, Method: Composition-based stats. Identities = 83/235 (35%), Positives = 139/235 (59%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG+ VRL +GD+ K+R Y P+ + GA LH+VDL GAK Sbjct: 3 VIPAVDIKDGSCVRLKKGDFNKRRVYSTSPVDVALYWEKHGASRLHIVDLDGAKSGWPTH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + I+ + VN+P+QVGGG+RS + + L++GV R+++G+ A+K+ ++VK + FG+ Sbjct: 63 LKTIREIALRVNIPLQVGGGIRSLKVIKKYLDSGVDRIILGTVALKNPELVKRALDNFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V+ +D R +VA GW + S V++E ++ VG+K + TDI+RDG L G Sbjct: 123 NRIVVGVDAR-----GGKVATEGWLKTSQVTVEDIISEMEEVGVKTFIYTDINRDGMLKG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 ++ + V + + +SGGI D+ L+ G++ IVG+AL EG ++ Sbjct: 178 PDIEGIKRVL-KSTKARIIASGGISSRQDLINLKAIGIKAAIVGKALYEGNLPLE 231 >UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PWX6_9BACT Length = 243 Score = 278 bits (713), Expect = 1e-73, Method: Composition-based stats. Identities = 76/238 (31%), Positives = 127/238 (53%), Gaps = 7/238 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL G VRL QG ++ + +DP+ + + QGA+ LH+VDL GA D + Sbjct: 2 IIFPAIDLKGGKCVRLTQGKKDEETVFSDDPVDMAKSWEDQGAQYLHVVDLDGAFDGLPK 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ +V +N+P++ GGG+R+ E V ++L+ GV RV++G+ A+ S V+ F Sbjct: 62 NLSIVEQIVNNINIPIEFGGGLRTTESVKSVLDLGVERVIIGTKALDSPSWVEELCSLFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +D + N +VAV GW S + ++ TDIS+DG L Sbjct: 122 G-RVAVGIDAK-----NGKVAVHGWTSLSEKTAIDFAREMEKFSPCAIIFTDISKDGMLQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N+ +E+ + + +SGGI + D+ + V G+IVG+AL G EA Sbjct: 176 GPNIESLKELLSSI-KTPVIASGGISSLKDIEYICQLPVEGMIVGKALYTGHIKFSEA 232 >UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MJ01_RHOM4 Length = 266 Score = 278 bits (712), Expect = 1e-73, Method: Composition-based stats. Identities = 90/247 (36%), Positives = 138/247 (55%), Gaps = 10/247 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ G VRL+QG Y ++ Y +DP+ + Q A VLH+VDL A+ Sbjct: 3 LVIPAIDIRGGRCVRLYQGSYERETVYFDDPVKMACLWRVQNARVLHVVDLDAAR-GQGH 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + V++P+QVGGGVR+ ED+ ALL+ GV RVV+G+ AV+ ++V R+G Sbjct: 62 NREVIGAICRTVDIPIQVGGGVRTLEDIEALLQVGVYRVVLGTAAVREPELVSEAIARYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D R + +V V GW E +GV +L G++ + TDISRDGTL Sbjct: 122 CSRVVVGIDAR-----DGEVRVQGWTEGTGVDAVELALDMERRGVRRFVYTDISRDGTLE 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G NV +Y + + +SGG+ D+ L+ V VI+GRAL E +F ++ Sbjct: 177 GPNVEMYRTLGLHLKKARITASGGVSGYRDLMRLQELEPYRVDSVIIGRALYENRFPCQQ 236 Query: 238 AIACWQN 244 CW + Sbjct: 237 -FWCWHD 242 >UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=117 Tax=Enterobacteriaceae RepID=HIS4_BLOFL Length = 251 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 123/248 (49%), Positives = 175/248 (70%), Gaps = 4/248 (1%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALD+I+G VRL+QG Y Q YG +P L Y QGA ++HLVDL GA++P R Sbjct: 1 MIIPALDIINGDAVRLYQGKYQSQSHYG-NPYSILSTYVQQGATMIHLVDLDGARNPKNR 59 Query: 61 QIPLIKTLVAGV---NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 Q+ LIK L ++ +Q+GGG+R D+ LL+ GV RV++GS A+ VK WF Sbjct: 60 QLSLIKELTHTAITSHLKIQIGGGIRHATDIKTLLKFGVNRVILGSIAITHPKKVKQWFT 119 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 F +LVLALD+ ID + N++V + GWQ+ + + LE+++E Y VGLKHVLCTDIS+DG Sbjct: 120 YFNPSSLVLALDIYIDSKNNRKVVIHGWQKETNIQLEEVIENYNSVGLKHVLCTDISKDG 179 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 TL GSN++LY+ +C ++P+++FQ+SGG+ + ++ LR +GV +I+GR+ LE KFT+ E Sbjct: 180 TLLGSNINLYQSICYKWPKISFQASGGVAKLTEILQLRSSGVNSIIIGRSFLEKKFTLTE 239 Query: 238 AIACWQNA 245 AI+CWQNA Sbjct: 240 AISCWQNA 247 >UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Gammaproteobacteria RepID=HIS4_SHEDO Length = 250 Score = 276 bits (707), Expect = 5e-73, Method: Composition-based stats. Identities = 142/250 (56%), Positives = 182/250 (72%), Gaps = 5/250 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPA+DLIDG VVRL+QGDY KQ + PL +L+ Y QGA++LH+VDLTGAKDP +R Sbjct: 1 MIIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLKSYQDQGAKLLHIVDLTGAKDPNQR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 QI LI LVAG++V +QVGGG+RSE+ V LL GV RVV+GS AVK ++VK W ++G Sbjct: 61 QIKLISELVAGLDVDIQVGGGIRSEQQVTELLAIGVKRVVIGSLAVKEPELVKSWLNKYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVG-----LKHVLCTDISR 175 +DA+ LALDV I+ G K VAVSGWQ G +LE LV + G LKH L TDISR Sbjct: 121 SDAICLALDVNINANGEKIVAVSGWQSAGGKTLESLVAEFERPGSKQTALKHALVTDISR 180 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGTL G+N +LY E+ A YP + +Q+SGGI +DDV+A++ + G+I+G+ALL +FTV Sbjct: 181 DGTLTGANTALYTELAAAYPTILWQASGGIATLDDVSAVKDSKAAGIIIGKALLINQFTV 240 Query: 236 KEAIACWQNA 245 +EAI CW NA Sbjct: 241 EEAIQCWPNA 250 >UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=16 Tax=Campylobacter RepID=HIS4_CAMJD Length = 244 Score = 273 bits (699), Expect = 4e-72, Method: Composition-based stats. Identities = 125/244 (51%), Positives = 175/244 (71%), Gaps = 3/244 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPALDLIDG VVRL +GDY +++ Y +PL + ++Y GA+ LHLVDLTGAKDP+KRQ Sbjct: 4 IIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQ 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI+ L V+V +QVGGG+RS+E+V ALL+ GV RVV+GS A+K + ++FG+ Sbjct: 64 LVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGS 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +A+VLALD + E + VAV+ WQE S L ++++ Y GLKH+LCTDIS+DGT+ G Sbjct: 124 EAIVLALDTILKE--DYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV LY+ + +P++ Q+SGG+ + D+ L+G GVIVG+ALL+G F+V+E I C Sbjct: 182 VNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGI-CSGVIVGKALLDGVFSVEEGIRC 240 Query: 242 WQNA 245 QNA Sbjct: 241 LQNA 244 >UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Bacillales RepID=HIS4_BREBN Length = 249 Score = 273 bits (698), Expect = 5e-72, Method: Composition-based stats. Identities = 93/243 (38%), Positives = 136/243 (55%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+D+ G VRL QGDYG++ Y + PL + + QGA +HLVDL GAK+ Sbjct: 4 IVYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEGKPA 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + + VPVQVGGG+R+EE +A LEAGVARV+VG+ A++ + K + Sbjct: 64 NAAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQN-D 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + LD R N VA GW + V +L + + G + + TDI+RDGT+ Sbjct: 123 GDKIAIGLDCR-----NGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTDIARDGTMT 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G NV + A + +SGG+ +DD+ L GV G IVG+AL FT++E Sbjct: 178 GPNVEEIAAL-AMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYTDAFTLEE 236 Query: 238 AIA 240 A+ Sbjct: 237 ALQ 239 >UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=HIS4_BUCCC Length = 245 Score = 272 bits (697), Expect = 6e-72, Method: Composition-based stats. Identities = 103/242 (42%), Positives = 157/242 (64%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP+LD I G +VRL+QG+Y + Y D +++ Y QGA +HLVDL G +P R Sbjct: 1 MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q + NV QVGGG+RS+ D+ L AGV+++V+G++A+ + K W + +G Sbjct: 61 QKSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + VL++D+ I+ + ++A+ GW++ + ++L+ ++ ++P GLK++LCTDISRDGT + Sbjct: 121 SKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILCTDISRDGTFS 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+SLY+ + ++P + QSSGGI I D+ L+ V VIVGRALLE KFT EA Sbjct: 181 GPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK 240 Query: 241 CW 242 CW Sbjct: 241 CW 242 >UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Firmicutes RepID=HIS4_CLOD6 Length = 240 Score = 271 bits (693), Expect = 2e-71, Method: Composition-based stats. Identities = 83/238 (34%), Positives = 142/238 (59%), Gaps = 7/238 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ D VRL QG++ K Y ++PL + +GAE +H+VDL GA+ Sbjct: 2 IIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ + +++P+QVGGGVR +E V +L+ AGV RV++GS A+++ ++V+ + Sbjct: 62 NTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+++D + + +VAV GW+ S V L + +G++ ++ TDIS+DG L Sbjct: 121 KEKIVVSIDAK-----DGKVAVRGWEVVSNVDSLTLCKQLEKIGVQTIVYTDISKDGMLQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N +YE + A+ + +SGG+ I+DV L+ + G I+G+AL + K KEA Sbjct: 176 GPNFDIYERI-AKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEA 232 >UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_DESAP Length = 262 Score = 269 bits (690), Expect = 4e-71, Method: Composition-based stats. Identities = 86/243 (35%), Positives = 140/243 (57%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL G VRL QG ++ Y DP+ + + QGA LH+VDL GA + Sbjct: 2 LIIPAVDLRGGRCVRLFQGRADQETVYSTDPVAVARTWEEQGARRLHVVDLDGAFTGKPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ +V VN+PVQVGGG+R+ E+V LE GV RV++G+ A+ + + + +G Sbjct: 62 NSGVVLDIVKSVNIPVQVGGGIRNPENVKCYLEHGVDRVILGTAALTNPEFLDAVVAAYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+ +D R + +V V GW++ + + +E + G++ V+ TD+ RDGTL Sbjct: 122 -ERIVVGVDCR-----DGRVCVQGWEQTAATDVLPFLEELVRRGVRRVVFTDVKRDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKE 237 G N+ V A + ++ +SGG+ ++D+ AL+ GV VI+G+AL G T+ E Sbjct: 176 GPNLEEIARVAA-HTELKVIASGGVSRLEDLRALKKLEHLGVDSVIIGKALYAGTITLAE 234 Query: 238 AIA 240 A+A Sbjct: 235 ALA 237 >UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Chlorobiaceae RepID=HIS4_PROA2 Length = 261 Score = 269 bits (690), Expect = 4e-71, Method: Composition-based stats. Identities = 83/246 (33%), Positives = 130/246 (52%), Gaps = 9/246 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ DG VRL +GD+ +Q+ Y ++P + Q A++LH+VDL A Sbjct: 2 LIIPAIDIKDGKCVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGTMV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I+ +VA +++PVQVGGG+RS EDV L GV+RVV+GS AV + ++ F Sbjct: 62 NFEKIREIVATLDIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELLATFS 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D N + GW E+S + +L +G+K ++ TDISRDG + Sbjct: 122 PSQIVVGIDA-----ENGIPKIKGWTESSSMQDYELALEMKKLGVKRIIYTDISRDGMMQ 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G + + +SGG+ DD+ L+ GV VIVG+AL E F ++ Sbjct: 177 GVGYESTRRFAMKA-GMRVTASGGVTSSDDLKKLQTLEQYGVDSVIVGKALYESNFPCQQ 235 Query: 238 AIACWQ 243 ++ Sbjct: 236 LWYNYE 241 >UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Cyanobacteria RepID=HIS4_PROMS Length = 255 Score = 268 bits (687), Expect = 8e-71, Method: Composition-based stats. Identities = 81/240 (33%), Positives = 144/240 (60%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL++G VRL +GD+ K++D+ +P + + + +GA+ +H+VDL AK + Sbjct: 3 LIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSPTN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + VN+P+Q+GGG+RS+E + L GV +V++G++A++++++VK +F Sbjct: 63 DKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKFPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D + + +V+ GW E S + LV+ + + + TDI+ DGTL G Sbjct: 123 -RIIVGIDAK-----DGKVSTRGWLEQSNIFATDLVKEFSSFKIASFIVTDINTDGTLEG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKEA 238 +N + + + +SGG+G I D+ +L +G+ GVIVG+AL E KFT+ EA Sbjct: 177 TNEEFIKSIL-EITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFTINEA 235 >UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF74_THET1 Length = 243 Score = 268 bits (687), Expect = 1e-70, Method: Composition-based stats. Identities = 84/242 (34%), Positives = 148/242 (61%), Gaps = 8/242 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+++G +VRL QGDY +++ Y DP+ + + A GA+ LH+VDL GA+ Sbjct: 2 IVIPAIDILEGQLVRLTQGDYSRKKVYSYDPVVVARKWKAIGAQWLHVVDLDGARQGHPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +IK+++ VQVGGG+R+ ED+ +++E G +R+V+G++AVK + ++ ++ Sbjct: 62 NVDVIKSVIMEFGPQVQVGGGLRTLEDIQSIVELGASRIVLGTSAVKDPEFLREVCAKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V ALD R N VA+ GW ++SG+ + ++ + G+ ++L T I DGT+ Sbjct: 121 PDMVVAALDTR-----NGVVAIDGWTKSSGLDVLEVAKLVEDAGVGYILFTAIETDGTMT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G +++ + + + V +SGGI + +D+ L GV VIVG+AL EG+ +E I Sbjct: 176 GPDIAAVQRLMSHVS-VPVIASGGISEPEDLEELSKAGVYAVIVGKALYEGRLP-EEVIT 233 Query: 241 CW 242 + Sbjct: 234 TY 235 >UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Bacilli RepID=HIS4_STRSV Length = 242 Score = 267 bits (684), Expect = 2e-70, Method: Composition-based stats. Identities = 79/242 (32%), Positives = 130/242 (53%), Gaps = 5/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+D+ DG VRL +GD+ ++ D L + + + G ++H+VDL GA + Sbjct: 5 ILPAIDIKDGQAVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALEGRAAN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI + A + +QVGGG+RS E + L G+ RV++GS AVK+ + V+ ERFG+ Sbjct: 65 RDLIAQIKAETGLAIQVGGGIRSLEQIEDYLAVGIDRVIIGSMAVKNPEFVEAALERFGS 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+ +D + VA GW E S L +G++ + TD+ RDGTL G Sbjct: 125 GKIVIGIDAK-----EGLVATEGWLETSNQDYISLALAMEKIGVRLFVYTDVDRDGTLTG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N+ Y+++ A +SGGI DD+ ++ G+ G IVG+A G+ ++++ Sbjct: 180 PNIQHYQKLLASLKHAQVIASGGIQSADDLEEMKKLGLAGAIVGKAYYSGRISLEQIKEA 239 Query: 242 WQ 243 + Sbjct: 240 ER 241 >UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=23 Tax=Bacteria RepID=HIS4_THEEB Length = 257 Score = 267 bits (683), Expect = 3e-70, Method: Composition-based stats. Identities = 89/251 (35%), Positives = 131/251 (52%), Gaps = 15/251 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL+DG VRL QG+Y K + +DPL + GA LHLVDL AK R Sbjct: 3 VIPAIDLLDGKCVRLVQGNYDKVNVFHDDPLKVALYWQRLGAPRLHLVDLDAAKTGEPRN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI +VA + +PVQVGGG+RS + VA L GV R ++G+ A+++ +V + Sbjct: 63 YDLIGKIVASLEIPVQVGGGLRSRQAVADLFLQGVNRAILGTVALENPKLVASLAAEYPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LD R + VA GW E S + L + +G+ + TDI RDGTL G Sbjct: 123 -RIWVGLDAR-----DGYVATRGWLETSKILATDLAQNMAAMGVAGFVYTDIQRDGTLQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA---ALRGTGVRGVIVGRALLEGKFTVKEA 238 N+ ++ A +SGG+ ++D+ AL G+ G IVG+AL ++EA Sbjct: 177 PNIPALRQLLA-VTNRPVIASGGVSSLNDILSLFALTPHGLVGAIVGKALYTKAMDLREA 235 Query: 239 IAC-----WQN 244 + WQ+ Sbjct: 236 VRAVGQGRWQD 246 >UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=C7PAV4_CHIPD Length = 389 Score = 266 bits (680), Expect = 5e-70, Method: Composition-based stats. Identities = 92/236 (38%), Positives = 147/236 (62%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+IDG VRL QGDY +++ Y PL + + + G LHLVDL GAK A Sbjct: 148 VIPAIDIIDGKCVRLTQGDYAQKKVYNEHPLEVAKAFESIGIRRLHLVDLDGAKKGAVVN 207 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + N+ + GGG+++E+D+ + E G A +GS AVK + GW +++GA Sbjct: 208 WKVLEAIAGKTNLVIDFGGGIKTEDDLRIVYENGAALATIGSIAVKDPALFSGWVKKYGA 267 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + L DV+ +++AV GW E + +S+ +E + G++H+ CTDI++DG L G Sbjct: 268 DKIFLGADVK-----EEKIAVGGWLETTELSVFDFLEENVKQGVQHIFCTDIAKDGLLQG 322 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 +V+LYE++ R+PQ+ F +SGG+ + DV AL G GVIVG+A+ E + ++KE Sbjct: 323 PSVALYEKILQRFPQIDFVASGGVSTMADVHALAEAGCSGVIVGKAIYEERISMKE 378 >UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=HIS4_BUCBP Length = 241 Score = 266 bits (680), Expect = 6e-70, Method: Composition-based stats. Identities = 112/241 (46%), Positives = 161/241 (66%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP++DLI+G +VRL+QG+Y + Y N+ Y QGA+++HLVDL GA P + Sbjct: 1 MIIPSIDLIEGNIVRLYQGNYDTKTFYQNNIYDIALKYYNQGAKIVHLVDLDGALCPNNK 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LIK L+ N +QVGGG+RS +DV LL G RVV+GS+A+ + V+ W FG Sbjct: 61 QTSLIKNLLNYFNFHIQVGGGIRSYKDVETLLLNGAKRVVIGSSAINNITEVEKWLLEFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++VLALDV + G K+V ++GW+ S VSLE ++E + +G+K+VLCTD+ +DGT Sbjct: 121 YKSIVLALDVYVRNNGYKEVVINGWKNRSNVSLESVLERFSTLGIKYVLCTDVKKDGTCL 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N +LY+ + + V FQ SGGIG I DV + + +G++ +I+GRALLE KF++ EAI Sbjct: 181 GPNFTLYKNISKLFKNVCFQLSGGIGTISDVISAKKSGIKDIIIGRALLENKFSLLEAIR 240 Query: 241 C 241 C Sbjct: 241 C 241 >UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_THEYD Length = 244 Score = 264 bits (677), Expect = 1e-69, Method: Composition-based stats. Identities = 87/243 (35%), Positives = 133/243 (54%), Gaps = 8/243 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL DG VRL QG + + Y ++P + +GAEVLH+VDL GAK+ Sbjct: 3 IIPAIDLKDGKCVRLRQGKFSEVTVYYDNPEDAALRWQNEGAEVLHVVDLDGAKEGKIGN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P IK + ++VGGG+R ED+ LL G+ RV+VG+ AV+S D VK +RF Sbjct: 63 LPSIKKIREAFRGNIEVGGGIRRIEDIELLLSVGIDRVIVGTIAVQSPDFVKEVCKRF-P 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D + + VAV GW E + + +L G+ ++ TDISRDG L G Sbjct: 122 KKIIVGIDAK-----DGLVAVKGWVEVTEIRAIELALKMQDYGIWGIIYTDISRDGMLTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 N+ + + +V +SGG+ I+D+ L + GVI G+A+ G +KEA+ Sbjct: 177 PNIEATKAL-VESVKVPVIASGGVSSIEDIRKLAEIPQLWGVITGKAIYSGAIDLKEALR 235 Query: 241 CWQ 243 + Sbjct: 236 IIK 238 >UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Aquificales RepID=HIS4_SULSY Length = 239 Score = 264 bits (676), Expect = 2e-69, Method: Composition-based stats. Identities = 86/240 (35%), Positives = 144/240 (60%), Gaps = 10/240 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ G VVRL++G++ K + Y +P+ + + GAE +H+VDL GA + + Sbjct: 6 FIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEGLPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I +++++V VN+P++ GGG+RS E V A+L+ GV RVV+GS A ++ + E F Sbjct: 66 NIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIVESF- 124 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +++ +D + + +VA+ GW E + VS + + Y + + L TD+SRDG++ Sbjct: 125 PNKVIVGIDAK-----DGKVAIKGWTEKTEVSPLEFAKKYDDLDIFGFLFTDVSRDGSMI 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKE 237 G+NV E+ +SGG+G ++DV L R G+ GV+VG+A+ EGK +KE Sbjct: 180 GANVEATVELAKNLKH-PVIASGGVGSLEDVIKLYEKREFGIFGVVVGKAIYEGKIDLKE 238 >UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=24 Tax=Bacteroidetes RepID=HIS4_PARD8 Length = 239 Score = 263 bits (674), Expect = 3e-69, Method: Composition-based stats. Identities = 83/239 (34%), Positives = 137/239 (57%), Gaps = 5/239 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+IDG VRL QGDY ++ Y DPL + + G LH+VDL GA++ Sbjct: 4 LIPAIDIIDGKCVRLTQGDYATKKVYNEDPLEVAKMFEGNGIRRLHVVDLDGAREGRIIN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + ++ + GGG++ E+D+ E+G V GS AVK+ +M W +FG+ Sbjct: 64 YRILERIATRTSLIIDFGGGLKQEDDLEIAFESGAQMVTGGSIAVKNPEMFTSWISKFGS 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++L D + K++A+SGW+E + L ++ Y G+ V+CTDI+RDG L G Sbjct: 124 EKIILGADAK-----EKKIAISGWEETTSQELVPFIKGYYDKGITKVICTDIARDGMLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 + LY+E+ P + +SGG+ I+D+ L G+ VI G+A+ EGK +K+ + Sbjct: 179 PAIDLYKEIRDEIPFLYIIASGGVSSIEDIEKLSEAGIPAVIFGKAIYEGKIQLKDLLR 237 >UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_DESHD Length = 250 Score = 263 bits (673), Expect = 4e-69, Method: Composition-based stats. Identities = 89/245 (36%), Positives = 137/245 (55%), Gaps = 12/245 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL +G VRL QG YG P+ + + QGA+ LH+VDL GA Sbjct: 5 LFPAIDLKEGKAVRLLQGRMEDATVYGEQPVEVARKFKEQGADSLHVVDLDGAFAGKPVN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I L+ + VQVGGG+R+ E + LL+ GV RV++G+ AV++ ++V+ +RF Sbjct: 65 DAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQRF-E 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +A+V+ +D + + VAV GW E + + L VG+KH++ TDISRDG L G Sbjct: 124 EAVVIGIDAK-----DGLVAVQGWAEKTEIKALDLALRMKKVGVKHLVFTDISRDGMLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-----RGTGVRGVIVGRALLEGKFTVK 236 N+ E+ AR + +SGG+ ++D+ L RG + G IVG+AL G F++ Sbjct: 179 PNIQSTVEL-ARLSGLQVVASGGVSRLEDLRLLQEEANRGVSLEGAIVGKALYAGAFSLA 237 Query: 237 EAIAC 241 EA+ Sbjct: 238 EALRV 242 >UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Persephonella marina EX-H1 RepID=HIS4_PERMH Length = 241 Score = 263 bits (672), Expect = 5e-69, Method: Composition-based stats. Identities = 77/240 (32%), Positives = 137/240 (57%), Gaps = 10/240 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IPA+D+ DG VRL++GD YG+DP+ + + +GA+ LH+VDL GA + + Sbjct: 6 FVIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEGKPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I ++K +V V++PV+ GGG+RS E V +++E GV RVV+GS A +++ + + Sbjct: 66 NIDIVKDIVKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVSAYP 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +++ +D + + +VA+ GW E + + + + + L TD++RDG + Sbjct: 126 G-KVIVGIDAK-----DGKVAIKGWLEKTEYTPLDFARMFDDLDIWGFLYTDVNRDGAMV 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGKFTVKE 237 G N+ + + +SGG+G ++D+ L+ GV GV+VG+AL EGK +++ Sbjct: 180 GPNIEGTKYLAQNLKH-PVIASGGVGSVEDLKKLYDLKKYGVYGVVVGKALYEGKIKLEQ 238 Score = 47.3 bits (112), Expect = 4e-04, Method: Composition-based stats. Identities = 18/121 (14%), Positives = 49/121 (40%), Gaps = 5/121 (4%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS- 182 ++ A+D++ + G + + + G KH+ + DG G Sbjct: 7 VIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHI--VDLDGAFEGKP 64 Query: 183 -NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N+ + +++ + + + GG+ + V ++ TGV V++G + + + ++ Sbjct: 65 KNIDIVKDI-VKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVSA 123 Query: 242 W 242 + Sbjct: 124 Y 124 >UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_LACLS Length = 246 Score = 262 bits (671), Expect = 7e-69, Method: Composition-based stats. Identities = 84/237 (35%), Positives = 136/237 (57%), Gaps = 7/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL +G VRL++GDY K+ Y +PL Q + GA+ LHLVDL GAK R Sbjct: 3 IIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQTRN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLE-AGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ + N+ +++GGG+R+ + V+ LE GV RV++G+ A + D +K ++G Sbjct: 63 LEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYG 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D+R V+ SGW E + + ++ +G+K V+ TDIS+DGTL Sbjct: 123 LSRIVVGVDIR-----EGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISKDGTLT 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N LY+E+ + SGG+ D D+ + G+IVG+A EGK +++ Sbjct: 178 GPNFELYDEISKE-TSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEK 233 Score = 44.3 bits (104), Expect = 0.004, Method: Composition-based stats. Identities = 24/119 (20%), Positives = 51/119 (42%), Gaps = 6/119 (5%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS- 182 ++ A+D++ E + + ++ + + +G K++ + DG G Sbjct: 3 IIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHL--VDLDGAKLGQT 60 Query: 183 -NVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTVKEAI 239 N+ + ++ + + GGI ++D V+ L GV VI+G A E +KE + Sbjct: 61 RNLEIVRKI-KDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELL 118 >UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Faecalibacterium prausnitzii M21/2 RepID=A8S9L9_9FIRM Length = 239 Score = 262 bits (671), Expect = 7e-69, Method: Composition-based stats. Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL G VVRL QGDY + YG DP + + + A GA+ LH+VDL GAKD Sbjct: 3 LFPAIDLRGGQVVRLTQGDYDRMTVYGQDPCAQARSFVAAGAKNLHVVDLDGAKDGTLSN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I L + ++VGGG+R+EE + L GV R ++GS AV +++G Sbjct: 63 YDTIAALAKQGGLYIEVGGGIRTEERIEKYLSLGVGRCILGSVAVTDFAFTARMLQKYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D + + VA+ GW+E S + G ++ TDI+ DG + G Sbjct: 122 DKIAVGVDAK-----DGYVAIHGWKEVSAEPGVAFCKRLAEAGCTAIIYTDIACDGAMQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +N+SLY ++ A P VAF +SGGI ++ L+ G I+G++L G + + Sbjct: 177 TNLSLYRQLAAEVPGVAFTASGGISSEAELLELQQMGTAAAILGKSLYTGALDLARCVQL 236 Query: 242 WQN 244 Q+ Sbjct: 237 VQD 239 >UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Bacillales RepID=HIS4_BACLD Length = 245 Score = 262 bits (670), Expect = 9e-69, Method: Composition-based stats. Identities = 92/242 (38%), Positives = 137/242 (56%), Gaps = 10/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G VRL QGDY K+ YG+ PL +A +GA +HLVDL GA++ K Sbjct: 6 VYPAIDIRNGKCVRLIQGDYEKETIYGHSPLEMASRFAEEGASWIHLVDLDGAREGKKVN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ ++V VQVGGG+R+E+DV L GV RV++GS+AV + + VK + +G Sbjct: 66 GGHVISIADKLDVKVQVGGGIRTEKDVYDYLSQGVERVILGSSAVSNTEFVKKMLKAYGG 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LD R + V+ GW E S V E+L G + + TDI+ DG L+G Sbjct: 126 -HIAIGLDAR-----DGFVSTEGWLETSSVRAEELGRELANEGAEVFIFTDIATDGMLSG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKEA 238 N++ E+ AR +SGG+ + D+ AL GV G IVG+AL +FTV EA Sbjct: 180 PNINSTVEL-ARATGKQVIASGGVSSLADLEALASRASEGVSGAIVGKALYTNQFTVAEA 238 Query: 239 IA 240 + Sbjct: 239 LE 240 >UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=35 Tax=cellular organisms RepID=HIS4_GRAFK Length = 241 Score = 262 bits (670), Expect = 9e-69, Method: Composition-based stats. Identities = 84/236 (35%), Positives = 145/236 (61%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D+I+G VRL +GDY ++ Y DPL + + A G E LHLVDL GAK Sbjct: 3 IIPAIDIIEGKCVRLSKGDYATKKIYNEDPLEVAKSFEAHGIEYLHLVDLDGAKSSHIVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++T+ ++ + GGG+++++D+ E+G +++ GS AVK+ D+ + W ++FG Sbjct: 63 HKILETIANKTSLKIDFGGGLKTDKDLQIAFESGASQITGGSIAVKNSDVFQNWIQKFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++L D + ++++AVSGW E+S + ++ Y G+K+V+CTDIS+DG L G Sbjct: 123 KKIILGADAK-----DRKIAVSGWLEDSNEEIIPFIQNYEEKGVKYVICTDISKDGMLEG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 + LY+E+ + + +SGGI + D++ L G GVI+G+A+ E + ++K+ Sbjct: 178 PSFELYKEILSETKNINLIASGGISEFDELPKLAELGCEGVIIGKAIYENRISLKQ 233 >UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=31 Tax=cellular organisms RepID=HIS4_CHRSD Length = 249 Score = 262 bits (670), Expect = 9e-69, Method: Composition-based stats. Identities = 87/242 (35%), Positives = 129/242 (53%), Gaps = 11/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL DG VRL QG YG+DP+ + GA LHLVDL GA + Sbjct: 2 LVIPAIDLKDGQCVRLKQGRMDDSTTYGDDPVAMAARWVETGARRLHLVDLNGAFEGKPV 61 Query: 61 QIPLIKTLVA-GVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + ++P+Q+GGG+R+ E + A LEAGV+ V++G+ AVK V RF Sbjct: 62 NAEAVTAIARAYPDLPIQIGGGIRTAETIEAYLEAGVSYVIIGTQAVKEPAFVGEMCRRF 121 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 +++ LD R + VA GW E S + L + + G+ ++ TDI+RDG + Sbjct: 122 PG-HVIVGLDAR-----DGYVATDGWAEVSTLKAVDLAKRFADDGVSSIVYTDIARDGMM 175 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVK 236 G N++ E+ AR + +SGG+ + D+ AL G+ G I GRA+ EGK V Sbjct: 176 QGVNIAATAEL-AREGGLPVIASGGVTHLGDIEALLEVADAGILGAITGRAIYEGKLDVA 234 Query: 237 EA 238 EA Sbjct: 235 EA 236 >UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Thermoanaerobacter RepID=HIS4_THEPX Length = 235 Score = 260 bits (666), Expect = 2e-68, Method: Composition-based stats. Identities = 77/241 (31%), Positives = 132/241 (54%), Gaps = 8/241 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+++ VRL +GD+ + Y +P+ + + GA+ +H+VDL GAK Sbjct: 2 VLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ ++ ++VGGG+R+ E + L GV V++GS A+ +D++ +G Sbjct: 62 NGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++ +D + N +VAVSGW E + + +L + +G+K ++ TDIS+DGTL Sbjct: 122 -ERTIVGIDSK-----NGEVAVSGWLEKTKIKDMELAKKMKEIGVKTIIFTDISKDGTLN 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N E + V +SGGI I+D+ L+ G G I+G+AL GK K A+ Sbjct: 176 GPNFKALENILK--TGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALE 233 Query: 241 C 241 Sbjct: 234 V 234 >UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=209 Tax=Bacteria RepID=HIS4_HERAR Length = 265 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 78/251 (31%), Positives = 130/251 (51%), Gaps = 20/251 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL DG VRL QGD + + DP + + QGA LHLVDL GA + Sbjct: 2 LLIPAIDLKDGHCVRLKQGDMDQATVFSEDPADMARHWLEQGARRLHLVDLNGAFAGKPK 61 Query: 61 QIPLIKTLVAGV----------NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 P +K ++ V +PVQ+GGG+R + + L+ G++ +++G+ AVK+ Sbjct: 62 NEPAVKAILQAVREYAEKNGIEEIPVQLGGGIRDLDTIERYLDDGLSYIIIGTAAVKNPG 121 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 + F +++ LD + + +VA GW + SG + L + + G + ++ Sbjct: 122 FLHDACSAFPGQ-IIVGLDAK-----DGKVATDGWSKLSGHEVIDLAKKFEDYGCESIIY 175 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRA 227 TDI RDG + G N+ ++ + +SGG+ +I DV AL + G+ GVI GR+ Sbjct: 176 TDIGRDGMMGGVNIEATVKLAQSMT-IPVIASGGVHNIKDVEALCAVQEEGIEGVICGRS 234 Query: 228 LLEGKFTVKEA 238 + EG ++ A Sbjct: 235 IYEGTLDLRSA 245 >UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=91 Tax=Bacteria RepID=HIS4_SYNJB Length = 261 Score = 259 bits (664), Expect = 5e-68, Method: Composition-based stats. Identities = 96/249 (38%), Positives = 143/249 (57%), Gaps = 13/249 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL+ G VRL+QGDY + +DP+ + + +AAQGA LH+VDL GAK Sbjct: 10 VIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P+I+ +V + +PVQVGGG+RS E LL+ GV RV+VG+ AV+ D ++ + F Sbjct: 70 LPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPG 129 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D R QVA GW + + +LV+ G ++ TDISRDGTLAG Sbjct: 130 -RVWVGIDARQ-----GQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRDGTLAG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVR-GVIVGRALLEGKFTVKEAIA 240 N+ ++ A QV +SGGIG + D+ AL G I+G+AL G +++EA+ Sbjct: 184 PNLEQLRQILA-VSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEALR 242 Query: 241 C-----WQN 244 WQ+ Sbjct: 243 AVGPGRWQD 251 >UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=21 Tax=Bacteria RepID=HIS4_XYLF2 Length = 269 Score = 259 bits (663), Expect = 5e-68, Method: Composition-based stats. Identities = 108/241 (44%), Positives = 150/241 (62%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PALD+ +G VVRL QGDY +Q Y + LPR Q +A GA +HLVDL AK Sbjct: 4 IVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYT 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 PL++ + + VQ GGGVRS +DVA +L+AG ARVV+GS AV+ V W + FG Sbjct: 64 LAPLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFG 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +ALD R D G ++ V GW E + +LE L + Y GL+H+LCTDI+RDG L+ Sbjct: 124 PERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALAQQYAAAGLRHLLCTDIARDGMLS 183 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ +Y + A P V Q SGG D+ DV A + G G+++G+ALLEG+ +KEA+ Sbjct: 184 GPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKEAVQ 243 Query: 241 C 241 Sbjct: 244 H 244 >UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N0X3_9GAMM Length = 240 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 87/241 (36%), Positives = 139/241 (57%), Gaps = 2/241 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ G VRL QG + + + P+ R +A GA+ LH+VDL GA+ + + Sbjct: 2 ILIPAIDIQAGRCVRLKQGQFEQITIFDTPPVERAAYFAKIGAQRLHVVDLDGAQIGSMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+PLI ++ + VQ GGG+RS E AG+A +V+GS A+ ++++ + Sbjct: 62 QLPLICSM-QNTGINVQAGGGIRSLEQAKLCFSAGIANLVLGSIAISNRELATQIIQEIS 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++LALD+R+ G A GWQ S +L +V Y +G++ +LCTDI+ DG + Sbjct: 121 PKNIILALDIRLI-NGIPIPATHGWQTMSNRNLWDVVSYYQQLGIQQILCTDIACDGMMQ 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N SLY+E R+P + +Q+SGGI + +D+ AL GV I+G +L +G + E Sbjct: 180 GPNFSLYQEAVKRFPMIDWQASGGIRNQEDIEALDKLGVAAAILGLSLYQGTLHLAEYKP 239 Query: 241 C 241 C Sbjct: 240 C 240 >UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW7_9FIRM Length = 243 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 91/243 (37%), Positives = 143/243 (58%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ G VRL +GD+ K+ + + P + + QGA+ LHLVDL GA + Sbjct: 2 IIFPAIDIRGGKCVRLLKGDFAKETVFSDKPEEMAKKWQTQGAQFLHLVDLDGALAGRPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +K ++A V++PV++GGG+R+ E + +L GV RV++GS AV+ ++VK ++G Sbjct: 62 NLATVKAILAAVDIPVELGGGIRTLESIDEVLALGVRRVILGSVAVRDPELVKTACAKYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V+ +D + + VAV GW + V L + G+K ++ TDISRDGTLA Sbjct: 122 -DRIVVGIDAK-----DGIVAVDGWGVSGDVEATALAKEMKKAGVKTIIYTDISRDGTLA 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR---GTGVRGVIVGRALLEGKFTVKE 237 G NV ++ AR VA +SGG+ I D+ AL+ G+ GVIVG+++ G + E Sbjct: 176 GVNVEATAKL-ARESGVAVVASGGVKSIADIEALKPYEKAGIEGVIVGKSIYMGTLDLAE 234 Query: 238 AIA 240 AI Sbjct: 235 AIE 237 >UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillus RepID=HIS4_LACPL Length = 241 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 87/237 (36%), Positives = 133/237 (56%), Gaps = 5/237 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI PA+DL G VRL+QGD+ + DP+ + Q A G + LH+VDL GAK Sbjct: 3 MIFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSGRPE 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I + +++GGG+R+ E LE G+ R+++GS A+ +VK FG Sbjct: 63 NFATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLSEFG 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+ LD N VA+ GW E S + L++T G KH + TD++RDGT+ Sbjct: 123 GERIVIGLD-----GTNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTDVARDGTMQ 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N++LY+E+ A+ P +SGG+ ++ DV L+ +G + VI+G+AL EG T+ E Sbjct: 178 GPNLALYQELQAQVPTANLIASGGVRNLTDVQVLQASGFKDVIIGKALAEGGVTLAE 234 >UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Listeria grayi DSM 20601 RepID=C2BYH3_LISGR Length = 240 Score = 259 bits (663), Expect = 6e-68, Method: Composition-based stats. Identities = 87/244 (35%), Positives = 130/244 (53%), Gaps = 7/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G VRL+QGD+ K+ DP+ + +AA GA LH+VDL GA Sbjct: 3 IFPAIDIKNGKCVRLYQGDFAKETMMNADPIDQAAKFAAAGATFLHIVDLDGAVSGKPTN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I LI+ L V +P+QVGGG+R+ V L AG RV++GS A+ D VK ++G Sbjct: 63 IALIQRLQQQVKIPIQVGGGIRTMTQVDTYLRAGAERVIIGSAALSDPDFVKAAVTKYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D +++ +D + N VA GW + S +G+ ++ TDIS+DGTLAG Sbjct: 122 DKIIIGIDAK-----NGFVATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDISKDGTLAG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + + ++A +SGG+ D+ L G G I G+AL EGK T+ + + Sbjct: 177 PNFEELRAI-QKSARIAVIASGGVSSKADLEQLAAEGFYGAIAGKALYEGKITMADVLEV 235 Query: 242 WQNA 245 +A Sbjct: 236 EGHA 239 >UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Legionella pneumophila RepID=HIS4_LEGPL Length = 239 Score = 258 bits (661), Expect = 1e-67, Method: Composition-based stats. Identities = 89/239 (37%), Positives = 142/239 (59%), Gaps = 2/239 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL G VRL QG + + + P+ R +A GA+ LH+VDL GA+ + Sbjct: 2 LVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ LI ++ + +Q GGG+RS E AG++++V+GS A+ + D+ E+ Sbjct: 62 QLELICSM-QKTGIAIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIK 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VLALDVR+D + +A++GWQ NS SL ++V Y G+KH+LCTDI+ DG + Sbjct: 121 PENIVLALDVRVDTKV-PLLAINGWQNNSTSSLWEVVSYYENHGIKHILCTDIACDGMMN 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N LY++ +PQ+A+Q+SGGI + D+ L G+ VI+G L + +E + Sbjct: 180 GPNFDLYQQAVEYFPQIAWQASGGIRHMQDITTLGSLGISAVILGLMLYQDNVNFEELL 238 >UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Leptospirillum RepID=A3EUM5_9BACT Length = 247 Score = 258 bits (660), Expect = 1e-67, Method: Composition-based stats. Identities = 82/241 (34%), Positives = 137/241 (56%), Gaps = 7/241 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G VVRL QG + ++ YG DP+ + +G + LH+VDL GA++ Sbjct: 3 LYPAIDIRNGKVVRLTQGRFDQETVYGEDPVRTALQFRERGVQHLHVVDLDGAREGVPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ +V VQVGGGVRS++ + +AGV+R+++G+ A+K + E+ Sbjct: 63 RSLIREIVKAFRGFVQVGGGVRSKDIASFYYDAGVSRLILGTAAIKDPVFLGSMIEQH-P 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + +DV+ ++ +AV+GW + +++ +G++ + TDI RDG L+G Sbjct: 122 DLFYVGIDVK-----DESLAVNGWLDLDTQDPLEVMVRMSELGVRGFVYTDIHRDGLLSG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + YE + R +V +SGG+ DI D+A LR GV G IVG+A+ G+ + EA+ Sbjct: 177 PNFARYETLR-RTVRVPVIASGGVRDISDIARLREIGVDGAIVGKAIYTGEMDLTEALRL 235 Query: 242 W 242 Sbjct: 236 L 236 Score = 47.3 bits (112), Expect = 4e-04, Method: Composition-based stats. Identities = 24/91 (26%), Positives = 33/91 (36%) Query: 30 DPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA 89 DPL + + G D+ + +TL V VPV GGVR D+A Sbjct: 147 DPLEVMVRMSELGVRGFVYTDIHRDGLLSGPNFARYETLRRTVRVPVIASGGVRDISDIA 206 Query: 90 ALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L E GV +VG + + G Sbjct: 207 RLREIGVDGAIVGKAIYTGEMDLTEALRLLG 237 >UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=B4W8G6_9CAUL Length = 243 Score = 258 bits (659), Expect = 2e-67, Method: Composition-based stats. Identities = 109/241 (45%), Positives = 148/241 (61%), Gaps = 1/241 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL G + + Y P RL +AA+GAE +H+VDL GA+ Sbjct: 2 LIYPAIDLKDGVCVRLMHGKFDQVTRYDEQPATRLSAFAAEGAEWIHVVDLDGAEAGEAV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI L ++V +Q GGGVRS DVA LL+ GV+RVVVGS AV + V W + FG Sbjct: 62 QHALIGELTKAIDVKIQSGGGVRSANDVAKLLDTGVSRVVVGSLAVTQPNDVAAWLKGFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ + LA DV+I E G A+ GW ++SGV L ++ Y KH+L TD+ RDG + Sbjct: 122 AEHITLAFDVKI-EDGVPVPALKGWTQSSGVDLWTALDRYPKGLFKHLLVTDVGRDGAMT 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ L E+ R P + Q+SGG+ +DD+AA++ G G IVGRAL E +FT+ +AIA Sbjct: 181 GPNLELLAEIRRRRPDLVLQASGGVSSLDDIAAVKSLGCNGAIVGRALYENRFTLPDAIA 240 Query: 241 C 241 Sbjct: 241 T 241 >UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodopirellula baltica RepID=HIS4_RHOBA Length = 253 Score = 258 bits (659), Expect = 2e-67, Method: Composition-based stats. Identities = 80/246 (32%), Positives = 124/246 (50%), Gaps = 10/246 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK-R 60 I PA+DL G VRL QGDY +Q +G+DP+ + + GA+ LHLVDL A+ + Sbjct: 14 IWPAIDLRHGKPVRLRQGDYDQQTTFGDDPVEFAKRWQESGAKRLHLVDLDAARGDSPDA 73 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ ++ +P Q+GGGVR E + +LL GV R+VVGS A+K D +++ Sbjct: 74 NRDAVQRIIEATGLPCQMGGGVRDEITIESLLNVGVTRLVVGSRALKDPDWFVEMCDKYP 133 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPV--GLKHVLCTDISRDGT 178 LV +D R + +VA GW E S VS + + ++ TDI++DG Sbjct: 134 G-KLVAGIDAR-----DGKVATQGWLETSDVSAFEFATKLRSRTENIAAIVYTDIAKDGM 187 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 + G N E+ A + +SGG+ DD+ L + IVGR+L +G + E Sbjct: 188 MQGPNFEGLAEMAA-ASDIPLVASGGVTTYDDIKQLVEMKMPAAIVGRSLYDGVMELGEV 246 Query: 239 IACWQN 244 + + Sbjct: 247 VRLAGD 252 >UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBX0_9FIRM Length = 234 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 83/239 (34%), Positives = 136/239 (56%), Gaps = 7/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ D VRL QGDY KQ Y ++P +D+ +G + LH+VDL A Sbjct: 2 IIFPAIDIRDNKCVRLSQGDYDKQTVYFDNPFTVAEDFEKRGVKYLHIVDLDAALIGKLT 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK ++ N+ ++VGGG+R EE + ++ GV RV +G+ AVK +K E++ Sbjct: 62 NFDIIKKIITDTNMLIEVGGGIRGEEQIKKYVDIGVDRVSIGTKAVKDFAFLKEMSEKYP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + L+LDV+ ++ V + GW ENSG+ + ++ + L ++ TDI +DG L+ Sbjct: 122 Y-KISLSLDVK-----DEYVYIKGWSENSGILIWDYLDKIKDLPLTGIVVTDIKKDGMLS 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G + LY ++ + + SGG+ +DD+ L+ GVIVG+AL E KF+V++ I Sbjct: 176 GPSFELYRKL-KKATKHNIVVSGGVSSLDDINKLKEDDTYGVIVGKALYENKFSVEDII 233 >UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CALS8 Length = 237 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 82/239 (34%), Positives = 136/239 (56%), Gaps = 6/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+IDG VRL QGDY + ++Y DP+ + + + +GA LH+VDL GAK + Sbjct: 2 IVIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + ++ V+ GGG+R ++ + L AG+ +++GS K+ + V+ +RFG Sbjct: 62 NFEVIKRIKESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +LD V +SGWQE + +S+E+ + +G + ++ TDI DG L Sbjct: 122 NERFIASLD-----FEEGYVKLSGWQEATRISVEEGILHIKKLGFQKLIYTDIKTDGMLK 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N + + + + SSGGI ++DV L+ GV GVI+G+AL G + E I Sbjct: 177 GHNFEAAKYIRSLFDGF-LISSGGISSMNDVLKLKDIGVDGVIIGKALYTGHVKLNEII 234 >UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alteromonadales RepID=HIS4_PSEHT Length = 242 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 108/243 (44%), Positives = 159/243 (65%), Gaps = 1/243 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALD++ +VRL+QG Y + Y + RL++YA GA LHLVDL GA+DP+K+ Sbjct: 1 MIIPALDVLQNQIVRLYQGKYETVQFYPFELGARLKEYADSGAGKLHLVDLEGARDPSKK 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q I+ +NVP QVGGG+R E+DV+ L+AG +VV+GS AV+ ++ VK W E+FG Sbjct: 61 QWQHIQAATKALNVPYQVGGGIRCEQDVSDWLKAGANQVVIGSMAVEKREQVKAWIEQFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ V+ALDV G A GW S L +LV+ Y +G+ LCTDIS+DGT+ Sbjct: 121 AEHFVIALDVNKTATG-WAPATHGWLTESEFGLLELVDFYANLGVIDFLCTDISKDGTMT 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + +LYE++ + Q+SGG+ +DD+ L+ G+ G+I+G++LL+G F+V+EA+A Sbjct: 180 GPSFALYEDLIKHNSTIKVQASGGVSSLDDIKKLKELGIGGIILGKSLLDGAFSVEEALA 239 Query: 241 CWQ 243 + Sbjct: 240 VTR 242 >UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=17 Tax=Epsilonproteobacteria RepID=HIS4_CAMHC Length = 236 Score = 257 bits (657), Expect = 2e-67, Method: Composition-based stats. Identities = 85/239 (35%), Positives = 139/239 (58%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL +G VRL +G+ + Y + P + +A GA+ LH+VDL GA + Sbjct: 3 ILPAIDLKNGFAVRLKKGEMNSAKIYSDKPWELAEKFADLGAKWLHIVDLDGAFAGEAKN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ +V N+ ++VGGG+R EE + +GV+R ++GS A+K+ + VK +++ Sbjct: 63 AKTIEKIVKSTNLKIEVGGGIRDEERIKFYKNSGVSRFILGSAALKNPEFVKQMAKKY-- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + N VA GW E S + +L + Y G++ ++CTDIS+DG L+G Sbjct: 121 -KIAVGIDAK-----NGFVATEGWAEVSNIKACELAKIYADAGVEAIICTDISKDGMLSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAI 239 NV EE+ A+ + +SGG+ D+ D+ AL+ +G + GVIVG+A EG +KEA Sbjct: 175 VNVKFSEEI-AKSSGIKTIASGGVKDLSDIKALKQSGKIYGVIVGKAYYEGSIDLKEAF 232 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 84/237 (35%), Positives = 135/237 (56%), Gaps = 5/237 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI PA+DL DG VRL++GD+ ++ DP+ + + Y A LHLVDL GAK Sbjct: 1 MIFPAIDLQDGRSVRLYKGDFAQETVINPDPVDQAKQYEAAKVGALHLVDLDGAKAGKPV 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++K + A +++GGG+R +E V L GV RV++GS A+K+ + K +G Sbjct: 61 NVDIVKAVRAAFTGILEIGGGIRDKEAVDLYLSLGVDRVILGSVALKNPKLTKQVIAEYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ +V+ +D + N +VA GW + S V + L+ + G K+ + TD+ RDGT+ Sbjct: 121 AEHIVIGVDGK-----NGKVAAEGWLDQSDVPMTDLIGAMIEGGAKYFIVTDVDRDGTMQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G+N L + +P +SGG+ +++D+ +L GV IVG+AL EG T++E Sbjct: 176 GANEELLGNLQKEFPTARIVASGGVRNLEDIKSLEQKGVMDSIVGKALYEGTITLEE 232 >UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Euryarchaeota RepID=HIS4_METBU Length = 246 Score = 256 bits (656), Expect = 3e-67, Method: Composition-based stats. Identities = 81/246 (32%), Positives = 139/246 (56%), Gaps = 9/246 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ G V+L QG G + +DP+ D+ +QGA LHL+DL GA + + Sbjct: 5 VIPAVDMKGGKCVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIEGNRTN 64 Query: 62 IPLIKTLVAGV---NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 P+IK +V + +QVGGG+RS ED A LL+ G+ +V++ + A+K +++K + Sbjct: 65 APIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLLDIGIDKVILSTAALKDPELIKKLSDE 124 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 FG++ + +ALD + N ++++ GW + S + ++ + G +L T+I +G Sbjct: 125 FGSEHINVALDSK-----NGKISIEGWTKESEHTAVEMGSQFEEKGAGSILFTNIDSEGL 179 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 L G N EE+ + +SGG+ ++D+ L+ TG GV+VG AL + +FT+ EA Sbjct: 180 LNGVNPKPTEEL-VNAVTIPVIASGGVTTLEDIVTLKNTGAAGVVVGSALYKKRFTLTEA 238 Query: 239 IACWQN 244 I + Sbjct: 239 INIISD 244 >UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFDF6 Length = 236 Score = 256 bits (655), Expect = 5e-67, Method: Composition-based stats. Identities = 81/239 (33%), Positives = 136/239 (56%), Gaps = 7/239 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G +VRL +G Y + + Y DP L+ + +GA LH+VDL GAK Sbjct: 3 IFPAIDIKNGQIVRLTEGKYDQVKVYSKDPEEVLEHFTKEGATALHIVDLDGAKSGTIEN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IKT++ + Q+GGG+R E + L GV RV++G+ AV++ V+ +++ Sbjct: 63 QNTIKTILKNRHFVTQLGGGIRDESTINHYLNMGVDRVILGTVAVENPKFVEEMVKKYD- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + + QV +GW NS V + + +G+ ++ TDIS+DG +AG Sbjct: 122 QQIAVGVDEK-----DGQVRANGWLVNSKVDAIEFCKMLTAMGVATIIYTDISKDGMMAG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 +++ Y ++C +V +SGG+ I ++ L+ GV GVIVG+A+ EGK ++EA A Sbjct: 177 CDMASYRQLCKDR-KVNIIASGGVTSIAEIKELKRIGVAGVIVGKAIYEGKIALREATA 234 >UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RFK6_LEGLO Length = 246 Score = 256 bits (655), Expect = 5e-67, Method: Composition-based stats. Identities = 86/241 (35%), Positives = 136/241 (56%), Gaps = 2/241 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL G VRL QG + + + P+ R +A GA+ LH+VDL GAK + Sbjct: 2 ILIPAIDLQAGRCVRLRQGQFDQVTQFDMSPIDRASYFAKLGAKRLHIVDLDGAKIGTMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+PLI T+ V VQ GGG+RS E AG++ +V+GS A+ + Sbjct: 62 QLPLICTM-QHTGVTVQAGGGIRSLEQAKTCYSAGISLLVIGSIAITDPGLTTKIINEIS 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++LALD+R++ + A GWQ S ++L ++V Y +G+ +LCTDI+ DG + Sbjct: 121 PKNIILALDIRMENKI-PLPATHGWQTTSTMNLWEVVSFYQQLGITQILCTDIASDGMMQ 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N LY+E R+P +A+Q+SGGI DD+ L+ G++ I+G + + F +K ++ Sbjct: 180 GPNFDLYQEAVERFPNIAWQASGGIRHQDDINKLQKLGIKAAILGLTMYQDVFNLKSILS 239 Query: 241 C 241 Sbjct: 240 S 240 >UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Clostridia RepID=HIS4_SYNWW Length = 244 Score = 255 bits (653), Expect = 7e-67, Method: Composition-based stats. Identities = 85/247 (34%), Positives = 135/247 (54%), Gaps = 9/247 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL QG + Y + P + + QGA LH+VDL GA + + Sbjct: 2 IIYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I+ + A +++ QVGGG+R DV LL G +RV++G+ AV D + ++FG Sbjct: 62 NLKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VL LD + VAV GW S VS +G++ + TD+SRDG L Sbjct: 122 PERIVLGLDAK-----EGMVAVEGWVSTSSVSAIDFGLQMKALGIQTAIYTDVSRDGLLQ 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N++ +E+ A + +SGG+ +D++ AL+ GV G I+G+AL +GK + + Sbjct: 177 GPNLAAIKEM-ASSTGLDIIASGGVSSLDNIRALKELENDGVSGAIIGKALYDGKIGLVD 235 Query: 238 AIACWQN 244 A+ ++ Sbjct: 236 ALREAES 242 >UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DY29_METI4 Length = 248 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 87/242 (35%), Positives = 133/242 (54%), Gaps = 7/242 (2%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQI 62 A+DL G VVRL QG + YG+DP+ + +QGA+ LH+VDL GA R + Sbjct: 12 YAAIDLFKGQVVRLRQGKLEEMTVYGSDPVKTALFWQSQGADGLHIVDLEGAFSGTPRHL 71 Query: 63 PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGAD 122 L++ + V +P+Q GGG+R+ E V LE G RVV+GS V ++ E+ G + Sbjct: 72 DLLEKIAYAVTIPIQFGGGLRTVEQVLKALEGGAQRVVIGSKLVTDPGFLQELSEKIGPE 131 Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 +V ALD N ++ + GW+++SG SLE ++ G +L T+I DGTL G+ Sbjct: 132 KIVAALDT-----QNGEIQIEGWKKSSGYSLENFIKWVEQKGAGFLLYTNIQTDGTLKGA 186 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIAC 241 +V ++V ++ +SGGIG DV L G+ G I+GR+L EGK ++ E Sbjct: 187 DVRGTQKV-VEMSRLPVFASGGIGCTKDVEELLKLKGLYGAILGRSLYEGKISLSEIKKN 245 Query: 242 WQ 243 ++ Sbjct: 246 FK 247 >UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alphaproteobacteria RepID=HIS4_MARMM Length = 244 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 112/245 (45%), Positives = 160/245 (65%), Gaps = 2/245 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL+DG VVRLH+G + DYG+DP+ + + GA +H+VDL+GA+D A+R Sbjct: 2 ILYPAIDLLDGRVVRLHKGAFDAVTDYGDDPMRVAEQFGEAGAVWVHIVDLSGARDGARR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI++L + VQ GGGVRS ED+ LL AGV RV++GS AV + V GW + +G Sbjct: 62 QGALIRSLCE-TGLRVQTGGGVRSAEDIEDLLAAGVERVIIGSLAVTDTNRVAGWLQNYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + LALDVR G + A+ GW + + +L+ ++ Y GL H L TDI RDG L+ Sbjct: 121 GDRITLALDVRQIG-GQYRPALKGWTDMADTTLDDVISAYEGTGLAHALVTDIGRDGDLS 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N++LY+ + YP + +Q+SGG+ +DD+ A R G G I G+AL EG+FTV EAIA Sbjct: 180 GPNIALYKRLATDYPNIDWQASGGVSSLDDLRAARAAGAAGAITGKALYEGRFTVGEAIA 239 Query: 241 CWQNA 245 C ++A Sbjct: 240 CLRDA 244 >UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrio RepID=HIS4_DESVH Length = 249 Score = 254 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 75/243 (30%), Positives = 132/243 (54%), Gaps = 11/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL++G VRL +G + + +DP+ + + QG LH+VDL GA Sbjct: 2 IVFPAIDLMNGVCVRLRRGRADDETVFSSDPVATARHWQEQGGRWLHVVDLDGAFSGQPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 PLI+++ +++PVQ+GGG+R A LEAGV R+++G+ A++ D F Sbjct: 62 NAPLIRSICDALDIPVQLGGGIRDAATAKAYLEAGVERLIIGTIALEEPDAYAALCAEFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++LD ++ GW +SG+++++++ L G ++ TDI RDG Sbjct: 122 G-RIGVSLDA-----EGGKLKTKGWVADSGLTVDEVLPRLLEAGTAFIIYTDIDRDGMQT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL----RGTGVRGVIVGRALLEGKFTVK 236 G N+ E + A+ V ++GG+ ++DV AL R T ++G + GRA+ EG ++ Sbjct: 176 GVNLPALEHL-AKASTVPVIAAGGVATLEDVKALYPLSRTTNLQGAVSGRAIYEGTLDLR 234 Query: 237 EAI 239 A+ Sbjct: 235 TAM 237 >UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Proteobacteria RepID=HIS4_NITSB Length = 238 Score = 254 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 82/244 (33%), Positives = 134/244 (54%), Gaps = 10/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL DG VRL +G + Y ++P + + G+ LHLVDL GA + Sbjct: 3 ILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEPKN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + IK + A ++ +++GGG+R EE + ++ G+ R+++GS AVK+ VK ++ Sbjct: 63 LEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKYP- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + VAV GW + S + L + G++ ++CTD+ +DGTL+G Sbjct: 122 --IAVGIDA-----IDGFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVGKDGTLSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 NV + A + +SGG+ DI+D+ L+ TG V GVIVG+A EG ++EA Sbjct: 175 VNVDFTVSI-AEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLDLEEAFR 233 Query: 241 CWQN 244 QN Sbjct: 234 LVQN 237 >UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CARHZ Length = 243 Score = 254 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 80/246 (32%), Positives = 133/246 (54%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL+ VVRL QG+ ++ +Y P+ Y GA ++H+VDL A Sbjct: 2 ILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I ++ V++PVQVGGG+R E L++ GV+RV+VG+ AV + ++++ Sbjct: 62 NFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEML-TLD 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + +D + N VA+ GW E+S L +G+ ++ TDI+RDG+L Sbjct: 121 RDKVAVGIDAK-----NGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARDGSLT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKFTVKE 237 G N + ++ + +SGGI ++D+ R G + GVI G+A+LEGK +KE Sbjct: 176 GPNFNETLKLAID-TGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKE 234 Query: 238 AIACWQ 243 I + Sbjct: 235 GIRILE 240 >UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Firmicutes RepID=HIS4_CLOBA Length = 237 Score = 254 bits (650), Expect = 2e-66, Method: Composition-based stats. Identities = 83/243 (34%), Positives = 141/243 (58%), Gaps = 7/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+D+IDG VRL+QGDY K+ ND +++ GAE +HLVDL GAK Sbjct: 2 IILPAIDIIDGQAVRLYQGDYNKKEVVANDIFNIAKEFECLGAEYIHLVDLDGAKSGYCV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I L V+VP++VGGG+R+ E + L+E G++RV++G+ A++ + ++K E +G Sbjct: 62 NEKIILKLAQTVDVPIEVGGGIRNFETIEKLIENGISRVILGTIAMEDEGLLKKAIECYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + N V GW S ++ + +G+K ++ TDIS+DGTL Sbjct: 122 -EKISVGIDCK-----NGYVYGRGWLAESKLNYLDFAKNMESLGVKSIIVTDISKDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N + ++ + + +SGGI DI+++ L+ + G I G+A+ G ++KEAI Sbjct: 176 GPNFDMLMKL-KKLVNIDITASGGIRDIENIKELKNIDIYGAITGKAIYSGNLSLKEAID 234 Query: 241 CWQ 243 + Sbjct: 235 ITR 237 >UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_CLOK1 Length = 238 Score = 254 bits (649), Expect = 2e-66, Method: Composition-based stats. Identities = 77/244 (31%), Positives = 138/244 (56%), Gaps = 7/244 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+DL G VRL++GD Q DP + ++GA+ LH+VDL GA + Sbjct: 2 IILPAIDLKGGKCVRLYKGDMNSQEVVARDPFETALKFKSEGAQYLHMVDLDGALKGSGE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I +V V+VP++VGGG+R+ E + ++ GV+RV++G+ A+K++++V E + Sbjct: 62 NLDIISKIVKNVDVPIEVGGGIRNIETIDKFIKLGVSRVILGTAALKNKELVIKAVENYD 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + + A GW S + + +G++ ++ TDIS+DGTL Sbjct: 122 -EKIAVGIDAK-----DGVPAADGWTTLSKTNYIDFGKEMEKIGVQTLIFTDISKDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+N+ ++ + +SGGI DI+D+ +L+ V G IVG+A+ ++K+AI Sbjct: 176 GTNLEQLLKL-KNSVKCNVIASGGIKDIEDIKSLKKENVYGAIVGKAIYAKTLSLKKAIE 234 Query: 241 CWQN 244 N Sbjct: 235 IGGN 238 >UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Chlorobiaceae RepID=HIS4_CHLT3 Length = 262 Score = 254 bits (649), Expect = 3e-66, Method: Composition-based stats. Identities = 78/240 (32%), Positives = 132/240 (55%), Gaps = 9/240 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ G VRL +GD+ +++ Y ++P + Q A+++H+VDL A Sbjct: 2 LIIPAIDIKGGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALTGKPE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 IK +V +++P+++GGG+R+ ED A L+ GV RVV+GS AVK+ +V E++G Sbjct: 62 NFDKIKQIVDTLDIPIEIGGGIRTAEDAARYLDIGVYRVVIGSAAVKNPSLVSQLIEKYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D + +SGW E+S +L G++ ++ TDI+RDGTL Sbjct: 122 PRKIVVGIDA-----EDGIAKISGWTESSQKKDYELALEMKDRGVERIIYTDITRDGTLE 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA---ALRGTGVRGVIVGRALLEGKFTVKE 237 G + + Q+ +SGG+ D++ L GV VI+G+AL E +F ++ Sbjct: 177 GVGYETTKAFAEKA-QMRITASGGVFGKQDLSKLCKLEHLGVDSVIIGKALYEERFPCQK 235 >UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9Y4_9FIRM Length = 245 Score = 253 bits (647), Expect = 4e-66, Method: Composition-based stats. Identities = 75/242 (30%), Positives = 130/242 (53%), Gaps = 10/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL G VRL +G++ K+ Y DP + +A GA +H+VDL GA Sbjct: 6 LYPAIDLRGGMCVRLEKGNFSKETVYSKDPGAMARRFAEAGARTIHVVDLDGALAGKSEN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + IK ++ + ++VGGG+R+ E + LL GV++V++GS A+ +V+ F Sbjct: 66 LSAIKAILREGGISIEVGGGIRTYEQIEGLLSLGVSQVILGSAAIYDPQLVERANRDFPY 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+ +D + N A GW+++S ++ E L G + ++ TDISRDG + G Sbjct: 126 -KIVVGIDAK-----NGYAAADGWEKDSNLTAEALARRVAAAGTERIIFTDISRDGMMNG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKEA 238 SN+ + + V +SGG+ ++D+ L+ G+ G I+G+AL G F++ +A Sbjct: 180 SNIEATAALY-QACGVPITASGGVSSLEDIRRLKARETDGIEGCIIGKALYAGAFSLSDA 238 Query: 239 IA 240 + Sbjct: 239 LK 240 >UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=HIS4_UNCTG Length = 244 Score = 253 bits (646), Expect = 5e-66, Method: Composition-based stats. Identities = 77/246 (31%), Positives = 141/246 (57%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ G VRL QG+ + Y DP+ + + ++GA+ LH+VDL GA Sbjct: 2 IIIPAVDIRQGNSVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTNI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + A V++PV+VGGG+R+ + + + + G A ++G+ A + ++VK R+G Sbjct: 62 NKAIIKNICAAVDIPVEVGGGIRNMDKIKEVFDIGAAYAILGTVAFNNPEIVKKAITRYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ +++A+D + + +VA+SGW++ + + +LV +G++ +L TDISRDG Sbjct: 122 SEKIIVAVDAK-----DGKVAISGWKDITPIEASELVNKLKEIGVQEILYTDISRDGMFT 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G + + +++ + +SGG+ ID++ L+ GV IVG AL F +++ Sbjct: 177 GPDFAGLKKLSE--SGMRIIASGGVKTIDNLVKLKKYEKDGVFAAIVGSALYTDDFKLED 234 Query: 238 AIACWQ 243 AI + Sbjct: 235 AIEEIE 240 >UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6X1_NATTJ Length = 246 Score = 253 bits (646), Expect = 5e-66, Method: Composition-based stats. Identities = 79/248 (31%), Positives = 139/248 (56%), Gaps = 13/248 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL +G VRL +G+ G ++ Y ++P + + QGA LHLVDL GA + + Sbjct: 5 LIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQGSVKN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ + V++PVQVGGG+RS E + L+ GV +V++G+ A +D ++ E F Sbjct: 65 STIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALELF-H 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D++ +VA GW S + +G+ V+ TDIS+DG L G Sbjct: 124 KNIIVGVDIK-----GGKVATEGWVNVSDTKTYDYLSELTELGVPRVILTDISKDGKLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT------GVRGVIVGRALLEGKFTV 235 N+ L++E+ A + ++ SGG+ ++D+ ++ + GVI+G+AL EGK + Sbjct: 179 PNLELFKEL-AIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDL 237 Query: 236 KEAIACWQ 243 + A+ + Sbjct: 238 QGALETIR 245 >UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=root RepID=HIS4_PELUB Length = 239 Score = 253 bits (646), Expect = 6e-66, Method: Composition-based stats. Identities = 76/242 (31%), Positives = 129/242 (53%), Gaps = 8/242 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ D VRL +GD+ + +Y P+ + Y G + LH+VDL GA Sbjct: 3 IFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGETVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +IK +V ++ ++VGGGVRS + + + AGV +V++GS A+K+++ +K ++F Sbjct: 63 LDIIKEIVHKFDLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKF-P 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + L LD + + ++VSGW+ENS ++ G ++ TDI+RDGT Sbjct: 122 NKIALGLDAK-----DGYLSVSGWKENSNQLTLDFLKEVNDYGASRLIYTDINRDGTKES 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIA 240 N V A SGG+ IDD+ +G + G+IVG+A+ +G ++E + Sbjct: 177 PNFEETTNV-ANVSNCPVIISGGVSSIDDIKKAKGLKNIEGIIVGKAIYDGDIKLEELVK 235 Query: 241 CW 242 Sbjct: 236 EL 237 >UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZT22_9SPHI Length = 239 Score = 252 bits (645), Expect = 7e-66, Method: Composition-based stats. Identities = 87/228 (38%), Positives = 142/228 (62%), Gaps = 5/228 (2%) Query: 10 DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLV 69 +G VRL QGDY ++R Y DP+ Q YA +G + LH+VDL GAK A + + L++ + Sbjct: 12 NGQCVRLTQGDYSQKRVYDKDPIEMAQKYADEGFQRLHVVDLDGAKSGAPKHLALVEQMA 71 Query: 70 AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALD 129 A N+ + GGG+++ E V A+L+AG A +GS AVK ++ KGW + FG+D ++LA D Sbjct: 72 AKTNLTIDYGGGIKTTEQVQAVLDAGAAMANIGSLAVKQPEVFKGWLQTFGSDKILLASD 131 Query: 130 VRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEE 189 V+ +++A++ WQ+ S VS+ + ++P GL CTD+S+DG L G + LY + Sbjct: 132 VK-----GEKIAINAWQDESEVSIYDFIADFIPSGLTQFFCTDVSKDGLLQGVALELYCK 186 Query: 190 VCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 + ++P + +SGG+ + D+ L G+ GVIVG+A+ E + ++E Sbjct: 187 LKQKFPTMTIIASGGVASMQDIEDLNKEGIDGVIVGKAIYENRIALEE 234 >UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Thaumarchaeota RepID=HIS4_NITMS Length = 236 Score = 251 bits (642), Expect = 1e-65, Method: Composition-based stats. Identities = 77/237 (32%), Positives = 138/237 (58%), Gaps = 8/237 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL+DG VVRL++GD ++ Y +DP+ + + GA++LH+VDL Sbjct: 3 IIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDLDATI-GTGSN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI+ + +++PV+V GG+R+EE + + RVV+G+ A K ++M++ +++ Sbjct: 62 LDLIEKISKELSIPVEVAGGLRNEEIIDRAISF-SNRVVIGTMAFKDKEMLQRIAKKYDF 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D + + GWQE++ L + ++ +G L T++S+DGTL G Sbjct: 121 SKIVISVD-----HIDGFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVSKDGTLEG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 ++ E+ CA +SGGI +IDDV+ ++ VI+G+AL E K +++EA Sbjct: 176 PDLEYLEKACA-VQNANVIASGGISNIDDVSDVQRKNAFAVILGKALYENKISIEEA 231 >UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=HIS4_THERP Length = 244 Score = 250 bits (639), Expect = 4e-65, Method: Composition-based stats. Identities = 94/238 (39%), Positives = 142/238 (59%), Gaps = 9/238 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL +G VRL +GD+ + Y +DP+ Q +A+ GA LH+VDL GA+ Sbjct: 2 IVIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPV 61 Query: 61 QIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 Q LI+ ++ V +V VQVGGGVR+ + V LL G ARVV+G+ A++ DM++ RF Sbjct: 62 QHELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALARF 121 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G + +V+A+D R + VA GW+ + +E++V + +G++ VL TD++RDGTL Sbjct: 122 GVERVVVAVDSR-----DGWVATHGWETVQAIRVEEVVHRVVLLGVRRVLATDVTRDGTL 176 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVK 236 N+ L + A V +SGG+G D+ AL GV IVGRAL EG+ + Sbjct: 177 TRPNLELMGRLAAL--GVTVIASGGVGSRSDLEALARVPGVEAAIVGRALYEGRVRFE 232 Score = 52.4 bits (125), Expect = 1e-05, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 4/91 (4%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAG--SNVSLYEEVCARYPQVAFQSSGGIGDID 209 ++ + + G + + + DG G L E V P VA Q GG+ +D Sbjct: 31 DPIEMAQRWASAGARWLHV--VDLDGARLGQPVQHELIERVIRAVPDVAVQVGGGVRTLD 88 Query: 210 DVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 V L G V++G A LE ++EA+A Sbjct: 89 AVERLLVGGAARVVIGTAALERPDMLREALA 119 >UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3165B Length = 246 Score = 249 bits (638), Expect = 4e-65, Method: Composition-based stats. Identities = 85/246 (34%), Positives = 139/246 (56%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+D+ G+ VRL QGD+ + Y DPL + + GA LH+VDL GA+D Sbjct: 2 ILYPAIDIRGGSAVRLRQGDFADETVYDADPLSAARAWVEGGARWLHVVDLDGARDGRPA 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++ + + VPV+ GGG+RS V A +EAG RV++G+ A D + +G Sbjct: 62 NLEHLRRIAGELGVPVEFGGGLRSRASVDAAIEAGAERVILGTAAFADVDFLDDVVAAYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+++DVR +VA +GW+E + + +++ G++ ++ ++I RDG L Sbjct: 122 -ERVVVSVDVR-----GGKVASAGWKEQTEMEAAAVIDHLQRRGVRKLVYSNIERDGMLT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGKFTVKE 237 G ++ V A + +F SGGIG +D +AA LR + GVIVG+AL E KFTV + Sbjct: 176 GPDLDEVRRV-AESVRGSFIYSGGIGSLDHLAALASLRQVNLNGVIVGKALYERKFTVGD 234 Query: 238 AIACWQ 243 A+ + Sbjct: 235 ALTALK 240 >UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=142 Tax=cellular organisms RepID=HIS4_METNO Length = 253 Score = 248 bits (633), Expect = 2e-64, Method: Composition-based stats. Identities = 82/248 (33%), Positives = 133/248 (53%), Gaps = 10/248 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL +G VRL QGD + + +DP + +A QG LH+VDL GA A Sbjct: 5 ILFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFAGAPM 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++A V +PVQ+GGG+R V L GV+RV++G+ AV+ V+ F Sbjct: 65 NAAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFVREAARLFP 124 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +D + + +VAV GW + S V+ E+L + G+ ++ TDI+RDG L Sbjct: 125 G-RIAVGIDAK-----DGRVAVEGWAKTSTVTAEELGRRFEDAGVAALIYTDIARDGVLK 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKFTVKE 237 G N+ + + A+ + +SGG+ I+DV + + G I GRAL +G+ +E Sbjct: 179 GLNIPMTLAL-AQAVSIPVIASGGLASIEDVHRILEPDCALLAGAITGRALYDGRIDPRE 237 Query: 238 AIACWQNA 245 A+A + A Sbjct: 238 ALAAIRRA 245 >UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Lactobacillus rhamnosus RepID=C7TCJ1_LACRG Length = 249 Score = 248 bits (633), Expect = 2e-64, Method: Composition-based stats. Identities = 79/243 (32%), Positives = 130/243 (53%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL+ G VRL QGDY +Q DPL ++++ A G + LHLVDL GA+ Sbjct: 3 LYPAIDLLAGQSVRLTQGDY-RQVSLTADPLTQVKNLTATGLKHLHLVDLDGARSQQPIN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I T+ +++GGG+R+ + L AG+ R+++GS AV + ++V ++FGA Sbjct: 62 QAVISTIRQHTPAFIELGGGIRTLAIMDHYLNAGIDRLILGSVAVTNPELVTQAVQKFGA 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D R +VA GW S S L++ + G+ + TDI RDG + G Sbjct: 122 DKIAVGIDARA-----GKVATDGWLTTSTQSPTHLMQAMVRRGVTTFIVTDIGRDGMMKG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV+L + P V +SGG+ + D+ AL+ G++ ++G+A G F + + Sbjct: 177 PNVALLAMLHQTVPNVNIVASGGVHTLADLTALQTAGIQAAVIGKAWQTGSFPLNKLKEL 236 Query: 242 WQN 244 N Sbjct: 237 EDN 239 >UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G189_ABIDE Length = 238 Score = 247 bits (632), Expect = 2e-64, Method: Composition-based stats. Identities = 74/240 (30%), Positives = 143/240 (59%), Gaps = 7/240 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ +G VVRL +GDY K Y + + + + A G E LHLVDL GAK+ Sbjct: 5 IIFPAIDIYEGKVVRLLKGDYNKMTIYSENVVDKACEIEAAGGEWLHLVDLEGAKEGNTP 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ + + V++GGG+R+E + + AGV R+++G+ A ++ + +++ Sbjct: 65 NFTYVEEICKKTGLKVEIGGGIRTEATIEKYINAGVNRIILGTKAATDKEFLNKMTDKY- 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +DV+ +++VA+ GW E + ++ V +G+K+++ TDI++DG ++ Sbjct: 124 REKIAVGIDVK-----DEKVAIKGWLEVTDKTIFDFVTELKEIGIKNIIVTDIAKDGAMS 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G NVS YE++ +++ + +SGG+ +DD+ L+ TG+ G I+G+A+ G ++EA+ Sbjct: 179 GINVSFYEKL-SKFTDMDITASGGVTTLDDLIRLKNTGIYGAILGKAMYTGNVDLREALK 237 >UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Leptospira biflexa serovar Patoc RepID=HIS4_LEPBA Length = 247 Score = 247 bits (632), Expect = 2e-64, Method: Composition-based stats. Identities = 81/246 (32%), Positives = 137/246 (55%), Gaps = 8/246 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+DL+D VRL QGDY K+ Y + P +Q + QGA ++H+VDL AK Sbjct: 2 LVLPAIDLLDNEAVRLLQGDYSKKTVYSSSPEKMIQVFEEQGATLIHIVDLNAAKTGKSE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 IK + V +++GGG+R+ +++ GV+R+++G+ AV+ ++V+ FG Sbjct: 62 NEKTIKKIKEKCTVDLELGGGIRTIDNMKFYDGLGVSRLILGTVAVEEPNVVEKAVSLFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V+ +D + N V GW+ NSG+ + + T +G++HV+ TDI+RDG + Sbjct: 122 QDRIVIGVDAK-----NGYVRTKGWESNSGILYKDFLTTMYGMGIRHVIFTDIARDGMME 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N Y E+ +P + +SGG+ +D+ L + G I G+A+ EGK +KE Sbjct: 177 GPNTLAYAELLETFPDLQLVASGGVSSKEDLVELYDKTNGKLFGAITGKAIYEGKLDLKE 236 Query: 238 AIACWQ 243 +I Sbjct: 237 SIRILN 242 >UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Planctomycetaceae RepID=A6C5Q1_9PLAN Length = 246 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 88/247 (35%), Positives = 134/247 (54%), Gaps = 13/247 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+D+ G VRL QGDYG++ +G+DP + +A GA+ LHLVDL GAK Sbjct: 3 ILPAIDIRGGKCVRLRQGDYGQETVFGDDPTEMARRWADGGAQRLHLVDLDGAKAGQPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALL-EAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ +V V+VP Q+GGG+R E + +L E G+ RV+VG+ A+K K +R+ Sbjct: 63 HEVVRKIVEAVSVPCQMGGGIRDEASIQLMLDEVGIDRVIVGTQALKDPQWFKQMVQRY- 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + L L LD R + +VA GW + S S L + Y+ V L V+ T+I+ DG + Sbjct: 122 PNRLALGLDAR-----DSKVATEGWLDVSETSAIDLAKEYVGVELAAVIYTNIANDGMMQ 176 Query: 181 GSNVSLYEEVCARY-PQVAFQSSGGIGDIDDVAALRGT-----GVRGVIVGRALLEGKFT 234 G + +++ A + +SGG+ + DV+ L + G I+GRAL EG Sbjct: 177 GVDEGTIQDMIALAELGLPVIASGGVTTLKDVSRLAEVSRTQPKLVGAIIGRALYEGTIE 236 Query: 235 VKEAIAC 241 V AI Sbjct: 237 VPAAIEA 243 >UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Deinococci RepID=C1CY68_DEIDV Length = 251 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 7/233 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIP +D+ G VRL++GD ++ Y + PL + + +GA ++HLVDL A Sbjct: 18 LIIPCVDIQSGRAVRLYEGDPERETVYFDSPLDAARHWVERGAGLVHLVDLDAA-TGRGE 76 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ + + + VPV+VGGG+R E LL AGV RVV+G+ AV++ +V G Sbjct: 77 NREVIRQITSELGVPVEVGGGIRDREAAEDLLRAGVHRVVIGTAAVRNPQLVADLIAAHG 136 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V++LD R +VA GW + SGV++ +L GL+ ++ TD++RDGTL Sbjct: 137 PERVVVSLDAR-----GLEVATHGWAQGSGVNVAELTPGLADAGLELLIFTDVTRDGTLK 191 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G N L +V + GG+ ++DDV L+ + G IVGRA+ EG Sbjct: 192 GLNRELMRQVRQLWINT-LIVGGGVANMDDVRLLQEERIEGAIVGRAIYEGTL 243 >UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW6_9FIRM Length = 252 Score = 246 bits (628), Expect = 6e-64, Method: Composition-based stats. Identities = 70/244 (28%), Positives = 122/244 (50%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ RD G DP+ Y + A+ L +D+T + D Sbjct: 6 IIPCLDVKDGRVVKGT--NFVGLRDAG-DPVELAARYDEERADELVFLDITASSDNRGTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + + + V +P VGGG+R+ ED+ +L+AG + + + AVK+ ++K E+FG Sbjct: 63 VNVARDCASKVFIPFTVGGGIRTVEDMRRMLKAGADKTSLNTAAVKNPGLLKEGAEKFGR 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +VLA+D R +V V+G + +G+ + V+ + +G +L T + DGT G Sbjct: 123 QCMVLAVDARRAGNHRWEVYVNGGRTPTGLDCLEWVKKAVALGAGEILLTSMDADGTKDG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 ++ L V + V +SGG G ++ + G V+ G+FTV++ Sbjct: 183 YDIELTRAV-SDAVNVPVIASGGAGKLEHFYDVLTLGHADAVLAASVFHYGQFTVRQVKE 241 Query: 241 CWQN 244 Q+ Sbjct: 242 YLQS 245 >UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrionales RepID=HIS4_DESDA Length = 250 Score = 246 bits (628), Expect = 7e-64, Method: Composition-based stats. Identities = 79/249 (31%), Positives = 131/249 (52%), Gaps = 12/249 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ +G VRL QG + + P+ + + GA LH+VDL GA D A + Sbjct: 2 IIFPAVDIQNGKAVRLKQGRAHESTVFAESPVDAARAWEEAGARWLHVVDLDGAFDGAAQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ + A + +PVQ+GGG+R A LEAGV+R+++G+ A++ + F Sbjct: 62 SRRIVRDICAALAIPVQLGGGIRDMHTAEAYLEAGVSRLIIGTLALEQPTLFADMCRAFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++LD ++ GW E++G++++ + L G V+ TDI RDG Sbjct: 122 G-RVGVSLDA-----EGGRLKSRGWVEDTGMTVDTALPRLLDDGAAFVIYTDIERDGMQC 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR----GTGVRGVIVGRALLEGKFTVK 236 G NV+ E + AR V ++GG+ ++D+ L T + G + GRAL EG +K Sbjct: 176 GVNVAALEHL-ARLSTVPVIAAGGVATLEDIQKLYPLTLETSLMGAVSGRALYEGTLDLK 234 Query: 237 EAIACWQNA 245 EA W +A Sbjct: 235 EA-NAWIDA 242 >UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillales RepID=HIS4_LACC3 Length = 238 Score = 245 bits (627), Expect = 7e-64, Method: Composition-based stats. Identities = 72/235 (30%), Positives = 119/235 (50%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL++G VRL QGDY + DPL + Q G LHLVDL GA+ Sbjct: 3 LYPAIDLLNGKSVRLTQGDYDQV-SLTEDPLYQAQRLTDAGFAHLHLVDLDGARAQRPIN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + + +++GGG+R+ + L G+ R+++GS AV D+V+ RFG+ Sbjct: 62 RTVITRIREQTSAFIELGGGIRTLAAMEIYLTIGIDRLILGSAAVSDPDLVEQAIARFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + + +D R +VA +GW S + L+ G+ + TDI++DG + G Sbjct: 122 NRIAVGIDTRA-----GKVATNGWLTTSQQTANALLTAMQQRGVTTFIVTDIAKDGMMQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 N L ++ PQ +SGGI + D+ L+ G++ I+G+A G + Sbjct: 177 PNAQLLADLQQAMPQATIIASGGISLLADLHRLQTAGIQAAIIGKAWQTGAIELA 231 >UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Euryarchaeota RepID=HIS4_METJA Length = 237 Score = 245 bits (627), Expect = 1e-63, Method: Composition-based stats. Identities = 78/244 (31%), Positives = 137/244 (56%), Gaps = 8/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL D V+L QGD K+ N+P+ + + +GAE LH++DL A Sbjct: 2 IIIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAF-GTGN 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK ++ VNVPV+VGGG+R+ E L+ GV RV+VG+ A+ + + G Sbjct: 61 NRDVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +VLA++ + +V + GW+E + ++++ + + ++L T++ +G L Sbjct: 121 KDKIVLAVECK-----EGKVVIKGWKEKVDKTPIEVIKEFEDK-VGYILFTNVDVEGLLK 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G NV + +E+ + + SGGI ++D+ AL+ G+ GV++G AL +G +K+A+ Sbjct: 175 GINVDIIKELIEK-TDIPIIYSGGITTLEDIKALKELGIYGVVIGSALYKGLIDLKKALE 233 Query: 241 CWQN 244 +N Sbjct: 234 IVKN 237 >UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=12 Tax=Bacteria RepID=HIS4_BRAHW Length = 238 Score = 245 bits (626), Expect = 1e-63, Method: Composition-based stats. Identities = 77/242 (31%), Positives = 137/242 (56%), Gaps = 7/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL +G VVRL +G+Y + Y DPL L + G+ LH+VDL GA D Sbjct: 3 ILPAIDLKNGEVVRLVEGNYDNKTTYFKDPLEVLDFFIESGSSYLHVVDLDGASDGETIN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ ++ ++ V+VGGG+R+E+ + L+ GV R ++G+ AV++ D ++ Sbjct: 63 FKTIEKVIKKCDLFVEVGGGIRNEDTIKKYLDIGVKRTILGTAAVENIDFTNNMINKY-K 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +++D R ++ +AV GW+E + + +G+ ++ TDIS+DG L+G Sbjct: 122 EHIAVSIDSR-----DRMIAVKGWKEINKQDSVEFCMKLDSMGIDTIIYTDISKDGKLSG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +N+ +Y+E+ + +SGG+ D++ LR + G IVG+A+ EGK +K+ I Sbjct: 177 TNLDIYKELREKIS-CNIIASGGVTFEDEIIKLRDMKINGAIVGKAIYEGKIDLKKIIEI 235 Query: 242 WQ 243 + Sbjct: 236 AK 237 >UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=6 Tax=Euryarchaeota RepID=D2RTG3_9EURY Length = 244 Score = 245 bits (626), Expect = 1e-63, Method: Composition-based stats. Identities = 92/237 (38%), Positives = 139/237 (58%), Gaps = 8/237 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG VV+L QG+ G ++ YG DP+ + + +GAE LHLVDL GA + + Sbjct: 9 VIPAVDMQDGEVVQLVQGERGTEKTYG-DPVDAARRWLDEGAEALHLVDLDGAFEGQRAN 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V+VP Q+GGG+R+ +D LLE GV RV++G+ AV++ D+V ER Sbjct: 68 GDAIDEVLETVDVPTQLGGGIRTADDAVDLLERGVDRVILGTAAVENPDIVAEISERH-P 126 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D++V++LD + + +V V GW E +G+S E Y +G +L T++ +G L G Sbjct: 127 DSVVVSLDAK-----DGEVVVEGWTEGAGISPVDAAERYAELGAAAILFTNVDVEGKLEG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 E+ V +SGG+ ++DV AL G V+VG AL EGKFT+ EA Sbjct: 182 VAAEPVREL-VEATDVPVIASGGVATLEDVRALEDAGAAAVVVGSALYEGKFTLAEA 237 Score = 60.4 bits (146), Expect = 5e-08, Method: Composition-based stats. Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 9/122 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHL--VDLTGAKDPAK 59 ++ +LD DG VV +G G P+ + YA GA + VD+ G + Sbjct: 129 VVVSLDAKDGEVV--VEGWTEGA---GISPVDAAERYAELGAAAILFTNVDVEGKLEG-- 181 Query: 60 RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 ++ LV +VPV GGV + EDV AL +AG A VVVGS + + + Sbjct: 182 VAAEPVRELVEATDVPVIASGGVATLEDVRALEDAGAAAVVVGSALYEGKFTLAEAQSAI 241 Query: 120 GA 121 + Sbjct: 242 DS 243 >UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hisF n=28 Tax=Bacteria RepID=HIS6_EXISA Length = 255 Score = 244 bits (623), Expect = 2e-63, Method: Composition-based stats. Identities = 66/243 (27%), Positives = 132/243 (54%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ ++ + RD G DP+ + Y GA+ L +D+T + + + Sbjct: 6 IIPCLDVKEGRVVKGI--EFVQLRDIG-DPVEIAKYYDESGADELVFLDITASTERRQTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + V +P+ VGGG+RS ED+++LL+AG +V + + AV+S +++ +RFG+ Sbjct: 63 LDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+DV+ + G V G ++ + + + + +G +L T +++DG +G Sbjct: 123 QCIVVAIDVKF-KDGEYYVYTYGGKQKTDLLAVEWAKQVAALGAGELLVTSMNQDGKQSG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++S+ E++ + +SGG G+ + V V ++ L + K TV+E Sbjct: 182 YDLSILEQLR-EVVDIPIIASGGAGNAEHVVEALE-KVDAALLASILHDRKTTVEEVKHV 239 Query: 242 WQN 244 ++ Sbjct: 240 CKS 242 >UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Thermus RepID=HIS4_THET2 Length = 235 Score = 244 bits (623), Expect = 3e-63, Method: Composition-based stats. Identities = 87/238 (36%), Positives = 132/238 (55%), Gaps = 8/238 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL G VRL++GD ++ YG DP+ + +GA +LHLVDL A Sbjct: 3 LIPAVDLKSGKAVRLYEGDPARETPYG-DPVEAALRFQEEGATLLHLVDLDRAL-GTGEN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ + A +++P Q+ GG+RS E + L G +R VVG+ AVK ++ E G Sbjct: 61 REAVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGP 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D L +ALD R +V VSGWQE + S L+ + +G++ +L TD+ RDGTL G Sbjct: 121 DRLAVALDAR-----GLEVVVSGWQEAASASALDLLRAWAEMGVRTLLYTDVRRDGTLLG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 + + V A +P GGI +D+ L+ GV G ++G+AL EG+ +KEA+ Sbjct: 176 LDREVVARVRAAWPH-ELIVGGGIASPEDLHLLQALGVDGALIGKALYEGRIRLKEAV 232 >UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Deinococcus RepID=HIS4_DEIGD Length = 243 Score = 243 bits (621), Expect = 4e-63, Method: Composition-based stats. Identities = 89/233 (38%), Positives = 130/233 (55%), Gaps = 7/233 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIP +D+ G VRL++GD ++ Y PL + +AA GA ++HLVDL A Sbjct: 11 LIIPCVDIQSGRAVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDAA-TGRGE 69 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + A + VPV+VGGG+R ALL+AGV RVV+G+ AVK+ +V+ G Sbjct: 70 NRAVITQITAELGVPVEVGGGIRDRAAAEALLDAGVGRVVIGTAAVKNPALVRELIAAHG 129 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V++LD R VA+ GW E SGVS+ +L GL+ ++ TD++RDGTL Sbjct: 130 PSRVVVSLDAR-----GLDVAIHGWAEGSGVSVAELAPLLAEAGLETLIFTDVTRDGTLR 184 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G + L +V + GG+ +DDV L G++G IVGRA+ EG Sbjct: 185 GLDRDLMRQVRQLWSNT-LIVGGGVATLDDVRLLAEEGIQGAIVGRAIYEGTL 236 >UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Nannocystineae RepID=D0LIZ1_HALO1 Length = 239 Score = 242 bits (619), Expect = 6e-63, Method: Composition-based stats. Identities = 86/242 (35%), Positives = 134/242 (55%), Gaps = 7/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL+ G VVRLHQG + Y N+P ++ +A+ GAE +H+VDL GA + Sbjct: 3 IYPAIDLLGGNVVRLHQGKRSEALVYSNEPAEIVRRFASAGAERVHVVDLDGAFSGERAH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + A VP+QVGGG+R + A+ G V+G+ AVK+ + Sbjct: 63 REALAEMAAASPVPLQVGGGIRDRAALEAVFATGAGFAVLGTAAVKNPAFAREACAAHPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++A+D R + VA+ GW E++G++ E+L + G +L TD+ RDG G Sbjct: 123 -CVIVAVDAR-----DGVVAIEGWVESAGITAEELGKRAADWGAAGLLYTDVMRDGAQVG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N++ + A+ + +SGG+G +DD+ AL GV V+VGRAL E KFT+ EA+A Sbjct: 177 PNIATTAAL-AQAVDIPVIASGGVGTLDDIRALAAAGVPSVVVGRALYENKFTLPEALAA 235 Query: 242 WQ 243 + Sbjct: 236 AR 237 >UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y7T0_9BACT Length = 237 Score = 242 bits (619), Expect = 6e-63, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 129/243 (53%), Gaps = 7/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL G VRL +GDY + Y + P D+AAQGA LHL+DL GAK+ Sbjct: 2 LIYPAIDLYAGQAVRLQRGDYARMTVYSDRPETVAADFAAQGARQLHLIDLEGAKNGGTP 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I + + QVGGG+RS + + A L+AGV RV++G+ A R+G Sbjct: 62 NLETIVAVKKSSGLFCQVGGGIRSMDAIVAYLDAGVDRVILGTAAATQAHFAARAVARYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A + + +D++ + AV GW E S + + G+ ++CTDISRDG + Sbjct: 122 A-RIAVGVDIK-----DGFAAVKGWTEKSPLKAFEFCRRMQSDGVSTLICTDISRDGMMQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+NV+LY+ + ++ +SGG+ +DDV L G+ G I+G+A ++ AI Sbjct: 176 GTNVALYKTLSTEL-KMRIIASGGVSSLDDVRRLAALGLYGAIIGKACYTKAISIAAAIE 234 Query: 241 CWQ 243 Q Sbjct: 235 VTQ 237 >UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hisF n=10 Tax=Bacteria RepID=HIS6_SULSY Length = 252 Score = 242 bits (618), Expect = 1e-62, Method: Composition-based stats. Identities = 64/244 (26%), Positives = 118/244 (48%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ D G DP+ Y +GA+ L +D+T + + Sbjct: 6 IIPCLDVDKGRVVKGV--NFVNLIDAG-DPVEIASVYDKEGADELVFLDITASSEDRNII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++K V +P+ VGGGVRS ED+ LLE G +V + + AVK+ +V+ RFG+ Sbjct: 63 LDVVKKTAETVFMPLTVGGGVRSLEDIRKLLENGADKVSINTAAVKNPSLVENAAIRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+D + + +V + G + +G+ + + +G +L T + +DGT +G Sbjct: 123 STIVVAIDAKKVGENKWEVYIHGGRTPTGIDAIEWAKAVESLGAGEILLTSMDKDGTKSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 ++ L + V + ++ +SGG G++ G + + + E Sbjct: 183 YDIELTKAV-SEAVKIPVIASGGAGNVQHFYEAFEYGKADACLAASLFHFKEIEISELKN 241 Query: 241 CWQN 244 +N Sbjct: 242 YLKN 245 >UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=144 Tax=Bacteria RepID=HIS4_CORJK Length = 258 Score = 241 bits (615), Expect = 2e-62, Method: Composition-based stats. Identities = 85/245 (34%), Positives = 130/245 (53%), Gaps = 9/245 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D+ DG VRL QG G + YG P+ + GAE +HLVDL A Sbjct: 12 LLPAVDVADGQAVRLVQGAAGTETSYGA-PIEAALAWQNAGAEWIHLVDLDAAF-GRGSN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L+K + ++V V++ GG+R +E + L G RV +G+ A++ + + R+G Sbjct: 70 FELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYG- 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + LD R + G ++ GW + G L +++E G+ ++ TD+SRDG L G Sbjct: 129 DKVAIGLDTR-EVDGEWRLRGRGWTSDGG-ELWEVLERLDSQGVSRLVVTDVSRDGMLNG 186 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKEA 238 N+ L EV A +SGGI +DD+ AL GV IVG+AL GKFT++EA Sbjct: 187 PNIDLLREVAA-ATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFTLEEA 245 Query: 239 IACWQ 243 + Q Sbjct: 246 LEAAQ 250 >UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=2 Tax=Pedobacter RepID=C6Y3G6_PEDHD Length = 249 Score = 240 bits (614), Expect = 2e-62, Method: Composition-based stats. Identities = 83/244 (34%), Positives = 141/244 (57%), Gaps = 11/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++DG VVRL +GDY ++ Y ++ Y + G E +H++DL GAK Q Sbjct: 3 IIPAIDILDGKVVRLTEGDYNQKTVYDVSIAEMIETYRSNGTEFIHIIDLNGAKGDFSNQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG- 120 L + ++ ++ VQ GGG+R+ + V LL+AG+ RV+VG+ A+ + D ++ + G Sbjct: 63 KALFE-VIKKTDMRVQYGGGIRTIKQVTDLLDAGIHRVIVGTQAITNPDFLQELSKEVGK 121 Query: 121 ----ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 A+ +V+A+DV ++ + SGW E+S + L V+ L +G LCTDI++D Sbjct: 122 KYDYANRIVIAIDV-----LDEVIKYSGWMESSPIKLMDYVDKCLQLGFFRFLCTDINKD 176 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G L G+ V LY+++ P + +SGG+ + D+ L +R V+VG+A+ E + T+ Sbjct: 177 GKLGGAAVELYKKLLEHSPFIKLIASGGVSSMKDIEELDKYDIRSVVVGKAIYENRITID 236 Query: 237 EAIA 240 + Sbjct: 237 QIKE 240 >UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=104 Tax=Bacteria RepID=HIS4_CLOB1 Length = 242 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 74/240 (30%), Positives = 142/240 (59%), Gaps = 7/240 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+DL +G +RL+QGD+ + DP+ + GAE +H+VDL GA + Sbjct: 2 IILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIK 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I +++ +N+PV++GGG+R+ + L+ AG+ RV++G+ A+ ++ +V+ +++ Sbjct: 62 NLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKYD 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + N++VA++GW S ++ + +G+++++ TDIS+DGTL Sbjct: 122 -EKIAIGIDAK-----NEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLK 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ E++ +SGGI DI+D+ ++ V G IVG+A+ G + EAI Sbjct: 176 GPNLKQLEKLNESI-NCNVIASGGIKDIEDLKGIKEMDVYGAIVGKAIYSGNINLNEAIK 234 >UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Leptospira RepID=HIS4_LEPBL Length = 241 Score = 240 bits (613), Expect = 4e-62, Method: Composition-based stats. Identities = 84/245 (34%), Positives = 143/245 (58%), Gaps = 10/245 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL D VRL +G+Y +++ Y ++P + +A GA +LHLVDL GA++ Sbjct: 2 IIIPAIDLFDNCAVRLFKGNYKEKKIYSSEPWKLAEGFAKNGATLLHLVDLNGARNQLGI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I + ++ VQ+GGG+R +E +A + G+ R ++G+ AV D++K + + Sbjct: 62 NEDSILKIRKTTSLKVQLGGGIRDKEKLAYYDKIGIDRFILGTAAVTDPDLLKFALDNYE 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+A+D + V ++GW+++SGV L++ G++H++ TDI++DGTLA Sbjct: 122 KERVVVAVDA-----IDGIVKIAGWEKDSGVRYRDLMDRLAKAGIEHIVFTDIAQDGTLA 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG----VRGVIVGRALLEGKFTVK 236 G N+ Y+E+ YP +SGGI + D+ L + GVI G+AL EGK + Sbjct: 177 GPNLKAYQEILNSYP-FQVIASGGISSLKDLMDLSSLKTKIPLYGVITGKALYEGKLDLA 235 Query: 237 EAIAC 241 +AI+ Sbjct: 236 KAISS 240 >UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomycetales RepID=D2Q1W2_9ACTO Length = 256 Score = 239 bits (612), Expect = 4e-62, Method: Composition-based stats. Identities = 85/246 (34%), Positives = 135/246 (54%), Gaps = 13/246 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+D+ DG VRL QG+ G + YG DPL + GAE +HLVDL A Sbjct: 17 VLLPAVDVADGQAVRLVQGEAGSETSYG-DPLAAATAWQEAGAEWIHLVDLDAAF-GRGS 74 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L+ + ++V V++ GG+R +E + A L G RV +G+ A++ + + +G Sbjct: 75 NRELLADVTGRLDVQVELSGGIRDDESLEAALATGARRVNIGTAALEDPEWCDRVIQTYG 134 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + LDVR + +A GW + G L +++E G + + TD+++DG L Sbjct: 135 -DRVAIGLDVR-----GRTLAARGWTKEGG-DLYEVLERLERAGCERYVVTDVTKDGMLQ 187 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N+ LY ++CAR + +SGG+ +DD+ AL GV GVIVG+AL G FT+ E Sbjct: 188 GPNLDLYRDLCARTAK-PIVASGGVSSLDDLRALATLVPDGVEGVIVGKALYAGAFTLTE 246 Query: 238 AIACWQ 243 A+ + Sbjct: 247 ALELTR 252 >UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB3_9BACT Length = 239 Score = 239 bits (612), Expect = 5e-62, Method: Composition-based stats. Identities = 87/239 (36%), Positives = 139/239 (58%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL VVRL GD+ K ++YG+DP+ +A GA +HL+DL GA+ + Sbjct: 6 IYPAIDLYSRKVVRLTGGDFEKIKEYGDDPVETALSFAEAGARWIHLIDLEGAEKGSPVH 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + A +PVQ GGG+R+EEDVA L +G RV +GS K + ++RFG Sbjct: 66 LKELEKVAASTGLPVQYGGGLRTEEDVALALSSGAKRVYLGSLLFKGSP--RTLWKRFG- 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++V ++DV+ N VA+SGW E + + E+ + L +G L T +SRDGT +G Sbjct: 123 NSIVPSVDVK-----NGTVALSGWTEVTQLPPEEAITELLRIGYSTFLVTSVSRDGTASG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ LYE + + ++GGI D D+A L GV G ++G+++ EG ++EA+ Sbjct: 178 PDLKLYERL--KKTDGRILAAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAVE 234 Score = 40.0 bits (93), Expect = 0.074, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 51/119 (42%), Gaps = 6/119 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P++D+ +GT V L Q P + + G + ++ + Sbjct: 125 IVPSVDVKNGT-VALSGWTEVTQLP----PEEAITELLRIGYSTFLVTSVSRDGTASGPD 179 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + L + L + + GG+R ++D+A L E GV+ V+G + + ++ E FG Sbjct: 180 LKLYERL-KKTDGRILAAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAVEEFG 237 >UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQP1_9RICK Length = 238 Score = 239 bits (611), Expect = 6e-62, Method: Composition-based stats. Identities = 74/241 (30%), Positives = 132/241 (54%), Gaps = 8/241 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL +GD+ +Q Y P+ + + + +G E LH+VDL K Sbjct: 2 IIYPAIDLQDGKCVRLTKGDFEQQTVYSRSPIEQAKAFEDKGFEFLHVVDLDRTIHKEKS 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + IK ++ + VQVGGG+R+++ V +++ GV V+G+ AV D++ +++ Sbjct: 62 NLKTIKEIIQSTGLKVQVGGGLRTKDTVEEVIDLGVENAVMGTAAVNDPDLLIEISQKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + LDVR +K +A+ GW++ + +S +ET + LK ++ TDI++DG Sbjct: 121 KNKISVGLDVR-----DKMIALKGWKDQTEISCFDFLETIKNLPLKSIIFTDINKDGMKQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDD-VAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N+ ++ A + +SGG+ IDD + GV+VG+A+ +G + E + Sbjct: 176 GINIDDTLKM-AESSNIPVTASGGVSSIDDIKLIKSKKKISGVVVGKAIYDGLIDLNELV 234 Query: 240 A 240 Sbjct: 235 K 235 >UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Proteobacteria RepID=HIS4_DESOH Length = 251 Score = 239 bits (611), Expect = 6e-62, Method: Composition-based stats. Identities = 93/244 (38%), Positives = 132/244 (54%), Gaps = 10/244 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IPA+D+ G VRL QGD + + +DP + +A GAE++H+VDL GA + + R Sbjct: 2 MVIPAVDIKGGKCVRLLQGDMNAETVFSDDPGAMAERWAEAGAELIHVVDLDGAIEKSPR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I L+ V VPVQVGGG+R + V + GVAR+V+GS AV D+V F Sbjct: 62 NLKAISALIRRVGVPVQVGGGIREIDTVKMYADLGVARIVIGSAAVNHPDLVTAACREFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +VL +D R + +VA GW + ++ L + G+ + TDI RDG Sbjct: 122 G-RIVLGIDAR-----DGRVATEGWTSTTDIAAADLAARFEGCGVAAINFTDIHRDGMRT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKE 237 G N+ E AR + +SGG+ IDD+ AL + GV GVI GRAL +G + E Sbjct: 176 GPNIPAIEAF-ARATAIPVVASGGVSTIDDIQALLGIQEFGVTGVITGRALYDGTLDLAE 234 Query: 238 AIAC 241 AIA Sbjct: 235 AIAV 238 >UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVE8_9SPHI Length = 244 Score = 239 bits (610), Expect = 7e-62, Method: Composition-based stats. Identities = 69/236 (29%), Positives = 124/236 (52%), Gaps = 3/236 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP++ LI+G VRL +GD+ + N+PL Q + + G + LHLVDL GA+ + Sbjct: 4 VIPSIWLINGKCVRLKRGDFATEEAISNNPLEIAQGFESIGIKRLHLVDLDGARRGEPKN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + N+ V GGV ++ DV E G V + S A + + +G Sbjct: 64 YHILEAIAGYTNLHVDFTGGVTTDGDVIKSFEFGAKTVTISSAAANYPERFSQFILSYGR 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LA D ++++ + GW + + + L +E + GLK++ C+D++RDG + G Sbjct: 124 EKINLAADT---NPADRKIKIRGWLKKTEIDLYDHIEFFYDRGLKYLKCSDVTRDGVMVG 180 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 N LY ++ ++P + +SGG+ I+D L+ GV + GRA EG +++ Sbjct: 181 PNFELYADLVKKFPNLNIAASGGVRSIEDFKELKKLGVNAAVFGRAYYEGMLKLED 236 >UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Caulobacter RepID=HIS4_CAUSK Length = 241 Score = 239 bits (610), Expect = 8e-62, Method: Composition-based stats. Identities = 83/242 (34%), Positives = 133/242 (54%), Gaps = 10/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL DG VRL GD K + N P + + + G LH+VDL GA + Sbjct: 2 ILYPAIDLKDGQCVRLLHGDMEKATVFNNSPADQAERFVRDGFSWLHVVDLNGAIEGKSV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++++ +++PVQ+GGG+R+ E V A +EAGV+RV++G+ AV D+V+ R Sbjct: 62 NTAAVQSILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPDLVRKAA-RLW 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +A+DVR + +VAV GW S + L + + VG+ ++ TDISRDG L Sbjct: 121 PEQIAVAVDVR-----DGKVAVDGWTGLSDLDAITLGKRFEDVGVAALIVTDISRDGALT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKE 237 G NV E+ A + +SGG+ + D+ L+ + G I+GR+L G E Sbjct: 176 GVNVEGVGEL-ADAVSIPVIASGGVASVADIERLKARPGVEIAGAILGRSLYAGTIRPAE 234 Query: 238 AI 239 A+ Sbjct: 235 AL 236 >UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hisF n=157 Tax=root RepID=HIS6_HELMI Length = 261 Score = 239 bits (610), Expect = 9e-62, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 120/249 (48%), Gaps = 11/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ RD G DP+ Y +GA+ + +D+T + D Sbjct: 6 IIPCLDVHGGRVVKGT--NFVNLRDAG-DPVELAAVYDKEGADEVVFLDITASSDGRAIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ V +P VGGG+RS ED+ +L+AG ++ + ++AV++ ++ +FG+ Sbjct: 63 LDVVRRTAEEVFIPFTVGGGLRSVEDIREMLKAGADKISLNTSAVQTPKLISDGAWKFGS 122 Query: 122 DALVLALDVRI------DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +V+A+D R + +V G ++ +G+ + + +G +L T + + Sbjct: 123 QCIVVAIDARRRRDAEGNPVEGWEVYTHGGRKPTGIDVLEWARRVEELGAGEILLTSMDK 182 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFT 234 DGT G ++ L V + + +SGG+G++D + L + ++T Sbjct: 183 DGTKDGYDIPLTRAV-SEAVTIPVIASGGVGNLDHIVEGLTVGKADAALAASIFHYREYT 241 Query: 235 VKEAIACWQ 243 + E + Sbjct: 242 IGETKEYLR 250 >UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Halobacteriaceae RepID=HIS4_HALWD Length = 245 Score = 238 bits (609), Expect = 1e-61, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 138/243 (56%), Gaps = 8/243 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG VV+L QG+ G + YG DP+ + + GA+ LHLVDL GA + + Sbjct: 10 VIPAVDMQDGDVVQLVQGERGTETRYG-DPVVAAKQWVEAGAKTLHLVDLDGAFEGDRMN 68 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V++PVQ+GGG+R+ D A+LL+ GV RV++G+ AV++ D+V E + Sbjct: 69 ATAVDAIIDAVDIPVQLGGGIRTANDAASLLDRGVNRVILGTAAVENPDLVAELAESYPG 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++++LD + +V VSGW E++G+ + G +L TD+ +G LAG Sbjct: 129 -RIIVSLDA-----ADGEVVVSGWTESTGIDPAVAAARFADYGACGILFTDVDVEGKLAG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 S+ V + +SGG+ +DD+ L TG +VG AL E KFT+ +A+ Sbjct: 183 IQSSVTARVI-DAVDIPVIASGGVASLDDIQTLHTTGAAATVVGTALYENKFTLADAMEV 241 Query: 242 WQN 244 ++ Sbjct: 242 CES 244 >UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Methanocaldococcus RepID=C9RH20_METVM Length = 237 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 74/244 (30%), Positives = 131/244 (53%), Gaps = 8/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL D V+L QGD K+ DP+ + + GAE LH+VDL A Sbjct: 2 IVIPAVDLKDKKCVQLIQGDPTKKHLELEDPVNVAKKWVHDGAEYLHIVDLDAALGCG-N 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I+ +V VN+PV+VGGG+RS L++ GV ++VVG+ A+ + Sbjct: 61 NVDVIEKIVEEVNIPVEVGGGIRSLTIAKRLMDIGVDKIVVGTKAITDPTFLNELLSEIE 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++LA++ + +VA+ GW+E + ++ + Y + +L T++ +G L+ Sbjct: 121 REKIILAVECKQ-----GKVAIKGWKETINKNPIEIAKKYEKK-VGGILFTNVDVEGMLS 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + E + + +V SGGI ++D+ L+ GV GVI+G AL +G +K+A+ Sbjct: 175 GIKTDIIETL-VKNVRVPIIYSGGITTLEDIKKLKEIGVDGVIIGSALYKGIINLKDALK 233 Query: 241 CWQN 244 ++ Sbjct: 234 ISKS 237 >UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41EB6 Length = 246 Score = 237 bits (606), Expect = 3e-61, Method: Composition-based stats. Identities = 69/240 (28%), Positives = 135/240 (56%), Gaps = 7/240 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+D+ G V+L QG G ++ +P + + GAEV+H++DL GA + + Sbjct: 9 LIMPAVDIRGGKCVQLVQGKPGSEQVVIENPEKVAKKWEDAGAEVVHVIDLDGALE-SVT 67 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I IK ++ V+VP+Q+GGG+RS E LL + R+++G+ +K+ +++ +G Sbjct: 68 NIETIKKILNEVSVPIQLGGGIRSIEYAEELLNLDIDRLIIGTMGIKNPEIISKLSNEYG 127 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ ++++LD + + +V + GWQE S ++ + + +G +L T++ +G L Sbjct: 128 SERVMISLDSK-----DNKVVIKGWQEKIDKSASEISKEFQELGAGSILFTNVDVEGLLG 182 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G V ++ + SGG+ +DD+ L+ TG +GV++G AL + K +++A+ Sbjct: 183 GFYVDPVIDL-VDSVDIPVVYSGGVTSLDDLKQLQTTGAKGVVIGSALYKDKIKLEDALK 241 >UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Methanomicrobiales RepID=HIS4_METMJ Length = 239 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 82/240 (34%), Positives = 125/240 (52%), Gaps = 8/240 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D++DG V+L QG YG DP + +GA+ LH+V+L GA A++ Sbjct: 3 IYPAVDILDGRCVQLVQGRPEAATVYG-DPAAWAHRWLDEGADGLHVVNLDGAFGRARKN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ ++GGG+RS ED A L+AGV RV+V + AV+ +M++ E FG Sbjct: 62 ADLIRAFTRETETFTELGGGIRSVEDAAGWLDAGVDRVIVSTQAVREPEMIRTLAEEFGG 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++ +D R +V + GW+ +G S E + +G +L T++ +G G Sbjct: 122 ERVMAGIDARA-----GEVMIEGWERPAG-SYLSWAERFESLGAGSLLYTNVDVEGLQQG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + E+ AR +V SGGI DVAALR G G ++G AL GK + EA+ Sbjct: 176 IAIEPVTELLARV-KVPVVVSGGISSPGDVAALRDAGAAGAVLGSALYAGKVRLPEAMEA 234 >UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Zymomonas mobilis RepID=HIS4_ZYMMO Length = 250 Score = 235 bits (601), Expect = 8e-61, Method: Composition-based stats. Identities = 79/246 (32%), Positives = 126/246 (51%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL +G VVRL +GD + Y +DP R + + GA LH+VDL GA Sbjct: 6 IIFPAIDLKEGHVVRLSEGDMDRATIYDDDPAARARQFYEAGARYLHVVDLDGAFAGHAM 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +V +++GGG+R + L G++RVV+G+ A ++ D+VK +++ Sbjct: 66 NAAAVDAIVKAFPGTIELGGGIRDMNAIDGWLSRGISRVVIGTAAFENPDLVKEAAQKYP 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+A+D R + V GW E S +S+ + E + G+ +L TD+ RDG Sbjct: 126 GQ-IVVAVDAR-----DGMVTTKGWAEQSEISVTDMAERFADAGVVALLYTDVGRDGLKK 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N A + +SGG+ DI D+ L G+ GVI GRA+ +G +K Sbjct: 180 GCNSEATLA-LAAATDIPVIASGGVKDIGDIELLARHTKDGIEGVICGRAIYDGSLDLKA 238 Query: 238 AIACWQ 243 A+A + Sbjct: 239 ALAIAR 244 >UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sibiricum 255-15 RepID=B1YL10_EXIS2 Length = 234 Score = 235 bits (601), Expect = 9e-61, Method: Composition-based stats. Identities = 86/240 (35%), Positives = 138/240 (57%), Gaps = 9/240 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL+ G VRL QGD+ +Q +G D L + + GA +HL+DL GAK Sbjct: 3 LYPAIDLMSGQAVRLKQGDFQQQTFFG-DALTIARRFKEDGATAIHLIDLDGAKAGEPLH 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI + + V+ GGGVR+ E V A + AG+ R+++G+ A++ + +++ ER G Sbjct: 62 LSLIADIKKETGLFVEAGGGVRNIETVEAYVGAGIDRILIGTVALEDEALLEQMIERAG- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D L +ALD + + V GW E S +LE+ +E + G+K L TDISRDG + G Sbjct: 121 DKLAVALDAK-----DGIVQTRGWLEASDWTLERAIEHLIQKGIKTFLYTDISRDGMMQG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +V + + + V +SGG+ ++DVA L+ G+ G ++GRALL+G ++KE + Sbjct: 176 PDVDGLDLL--KRDGVELIASGGVTTVEDVARLKEIGMDGAVIGRALLDGSLSLKEVLRV 233 >UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=C7P985_METFA Length = 272 Score = 234 bits (597), Expect = 3e-60, Method: Composition-based stats. Identities = 67/256 (26%), Positives = 126/256 (49%), Gaps = 24/256 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ + + RD G DP+ Q Y +GA+ L +D+T + + Sbjct: 6 IIPCLDIKDGRVVKGTK--FLNLRDAG-DPVELAQLYDDEGADELVFLDITASAEKRDII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ V +P+ VGGG++S ED +L AG ++ + + AVK+ +++K E FG+ Sbjct: 63 IDVVERTAEKVFIPLTVGGGIKSIEDFRKILRAGADKISINTAAVKNPNLIKEASEIFGS 122 Query: 122 DALVLALDVRI-------------------DEQGNKQVAVSGWQENSGVSLEQLVETYLP 162 +V+A+D + D +V + G ++ +G+ + + Sbjct: 123 QCVVVAIDAKRHYINEDEIDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKVEE 182 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRG 221 +G +L T I +DGT +G ++ L E+ ++ ++ +SGG G + V G Sbjct: 183 LGAGEILLTSIDKDGTKSGYDLILTREI-SKSVKLPVIASGGCGKPEHVYEAFVHGKADA 241 Query: 222 VIVGRALLEGKFTVKE 237 ++ L ++T++E Sbjct: 242 ALMAGILHYKEYTIEE 257 Score = 41.6 bits (97), Expect = 0.028, Method: Composition-based stats. Identities = 29/127 (22%), Positives = 50/127 (39%), Gaps = 11/127 (8%) Query: 6 LDLIDGTVVRLHQG-------DYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 +D ID VV++ G YG +++ G D + + GA + L + KD Sbjct: 141 IDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKVEELGAGEILLTSID--KDGT 198 Query: 59 KRQIPLI--KTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 K LI + + V +PV GG E V G A + + + ++ Sbjct: 199 KSGYDLILTREISKSVKLPVIASGGCGKPEHVYEAFVHGKADAALMAGILHYKEYTIEEI 258 Query: 117 ERFGADA 123 +++ AD Sbjct: 259 KKYCADR 265 >UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_ANADF Length = 238 Score = 233 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 76/235 (32%), Positives = 128/235 (54%), Gaps = 7/235 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL+ G VRL +GD+ + Y P + +++A GA +LH+VDL GAK Sbjct: 2 LVIPAIDLMGGEAVRLEKGDFATKTVYARHPAEKAEEFARAGATLLHVVDLDGAKAGWPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++ + + V++GGG+RS D+ +L GV VV+G+ AV+ +V+ +RF Sbjct: 62 NLDAVRAICEVPGIEVELGGGLRSLPDIEKVLALGVRYVVLGTAAVERLGLVEQACQRFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +D R N +V ++GW E +G++ + G+ V TD++RDG Sbjct: 122 GQ-VRAGIDAR-----NGEVKIAGWLEGTGLAAVDVARKVKGAGVGLVEYTDVARDGMFT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 G + + + A + +SGG+ +DDV A R G+ GVIVG+AL E + + Sbjct: 176 GVDAAGAARIQAEA-GIPVVASGGVASLDDVTACRAAGLAGVIVGKALYERRIDL 229 >UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_SYMTH Length = 249 Score = 233 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 84/245 (34%), Positives = 128/245 (52%), Gaps = 14/245 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL DG VVRL QG + YG DP+ +A GA +H+VDL GA + Sbjct: 5 LYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQN 64 Query: 62 IPLIKTLVAGV-----NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 ++ +V + V VQ+GGG+R+ E + A L GV+R ++G++A++ D+ Sbjct: 65 AAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSALEG-DVAARAV 123 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 RFG D + +++D R VA GW E + V L VG++ V+ TDI+ D Sbjct: 124 ARFGPDRVAVSIDAR-----GGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATD 178 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTV 235 G L G N + E + + +SGGI ++D+ L GV G I+GRAL G + Sbjct: 179 GMLTGPNFAELEMMGR--TGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDL 236 Query: 236 KEAIA 240 EA++ Sbjct: 237 AEALS 241 >UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Coriobacteriaceae RepID=C8WPG6_EGGLE Length = 257 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 83/242 (34%), Positives = 137/242 (56%), Gaps = 9/242 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D++ G VRL +GDY + Y +DP + Q + QGA LH+VDL GA+ Sbjct: 3 LLPAIDILGGKAVRLAKGDYDRVTVYHDDPAAQAQLFEEQGATWLHVVDLDGARSGIPEN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ ++ + V+VGGGVRS + +A L +AGV+RVV+G++ V D + ++G Sbjct: 63 IAIVERIMRKTLLKVEVGGGVRSLDTIARLADAGVSRVVLGTSLVADPDFAEAAIAQYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 L +D + +VAV+GW+E +GV+ E+L +G +H++ TDI+RDG G Sbjct: 122 KLLCAGIDAK-----GGEVAVAGWREGAGVAAEELARDMSALGFRHLVYTDIARDGMQTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT--GVRGVIVGRALLEGKFTVKEAI 239 + Y + + +SGG+ +DD+ L + GVI GRA+ EG +V+E + Sbjct: 177 IEAAAYVRMAEAFGH-PVIASGGVAGVDDIVRLGEVAGSIEGVIAGRAVYEGALSVQEGV 235 Query: 240 AC 241 Sbjct: 236 RA 237 >UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hisF n=27 Tax=cellular organisms RepID=HIS6_META3 Length = 275 Score = 232 bits (592), Expect = 1e-59, Method: Composition-based stats. Identities = 62/260 (23%), Positives = 120/260 (46%), Gaps = 28/260 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ ++ + RD G DP+ + Y QGA+ L +D+ + + Sbjct: 6 IIPCLDIKNGRVVKGT--NFVELRDAG-DPVELSKIYNEQGADELVFLDIGASHEKRDII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ V +P+ VGGG+R+ +D +L AG ++ V + A+ + D++K E +GA Sbjct: 63 EHLVEKTADQVFIPLTVGGGIRTTDDFRRILRAGADKISVNTAAIHNPDLIKQSSELYGA 122 Query: 122 DALVLALDVRIDEQGNK-----------------------QVAVSGWQENSGVSLEQLVE 158 +V+A+D + + +V + G ++ +G+ + + Sbjct: 123 QCVVVAIDSKRHYVNEEDLDSKQLEDKNVVKVDKNKYCWFEVFIYGGRKETGIDAIEWAK 182 Query: 159 TYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG 218 T +G +L T + DGT G ++ L + + ++ +SGG G + + G Sbjct: 183 TAEELGAGEILLTSMDADGTKDGYDIELTKSISTHI-KLPVIASGGCGAPQHIHQVFEYG 241 Query: 219 -VRGVIVGRALLEGKFTVKE 237 ++ L ++TV E Sbjct: 242 KADAALMASILHYREYTVGE 261 >UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=cellular organisms RepID=HIS4_THEON Length = 229 Score = 228 bits (583), Expect = 1e-58, Method: Composition-based stats. Identities = 75/242 (30%), Positives = 121/242 (50%), Gaps = 16/242 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL+ G VRL++G K + YG DP+ + + +H+VDL GA + Sbjct: 3 IYPAIDLMGGKAVRLYRGQKEKVKVYG-DPVEIASRFTEL-VDKIHVVDLDGAFTGKPQN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++K ++ + VQVGGG RS E +A E G V++G+ A + ++ + F Sbjct: 61 LDVVKEIIEETGLKVQVGGGFRSYESIAKAYEIGAENVIIGTKAF-DLEFLEKITDNFDG 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++LD R ++AV GW E S + + + E + + T I RDGTL G Sbjct: 120 --ITVSLDAR-----GGKIAVKGWLEESSLKVGEAYEMLREY-VDRFIYTSIERDGTLTG 171 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 E + + F +GG+ +DDV LR G G IVG+AL E + ++KE + Sbjct: 172 -----IESIERFWKDEEFIYAGGVSSVDDVLKLRRVGFSGAIVGKALYESEVSLKELLEV 226 Query: 242 WQ 243 + Sbjct: 227 LE 228 >UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZVN4_9SPHI Length = 246 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 69/236 (29%), Positives = 127/236 (53%), Gaps = 5/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P++ ++ G VVR +GD + + Y +PL ++ G + LHLVDL GAK Sbjct: 4 IVPSIAILGGKVVRTIKGDIDQVQVYDTNPLDLALEFENNGIKHLHLVDLDGAKARQIVN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ L + + + GG+ ++D+ E G V + AV ++ W +G Sbjct: 64 YNILEMLASYTQLEIDYTGGITRDDDIRTAFECGAKHVTAATVAVHEREKFLSWVITYGG 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++LA D + V GW++N+G+ L + +++Y G++ V T+I R+GTL G Sbjct: 124 NKVILAADA-----LDGVVLTKGWRKNTGIDLVEHIKSYHERGVRFVKTTEIGRNGTLEG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 N Y+++ +P++ +SGGI I+D+ L GV GVI+G++ +G+ +K+ Sbjct: 179 PNFDTYKKLRTEFPELQILASGGIRSIEDIEQLDALGVAGVIIGKSYYDGQIKLKD 234 >UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hisF n=354 Tax=cellular organisms RepID=HIS6_METBU Length = 273 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 64/264 (24%), Positives = 121/264 (45%), Gaps = 26/264 (9%) Query: 2 IIPALDL----IDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 IIP LD+ GTVV+ ++ + G DP+ + Y QGA+ L +D+T + + Sbjct: 6 IIPCLDVTLDASGGTVVKGV--EFVDLKKAG-DPVDLAKRYNEQGADELVFLDITASHEG 62 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 I +I+ V +P+ VGGG+ S EDV +L AG +V V + AVK+ + ++ Sbjct: 63 RSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREASN 122 Query: 118 RFGADALVLALDVRIDEQGN-----------------KQVAVSGWQENSGVSLEQLVETY 160 FG+ +V A+D + + +V + G +E +G+ Q + Sbjct: 123 IFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIYGGREPTGLDTVQWAKKV 182 Query: 161 LPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGV 219 +G +L T ++RDGT G ++ + +++ + +SGG+G+ + + Sbjct: 183 EELGSGEILLTSMNRDGTYDGFDIPITKKLSEEL-DIPIIASGGVGNPEHMYKGFVDGKA 241 Query: 220 RGVIVGRALLEGKFTVKEAIACWQ 243 + G++TV++ + Sbjct: 242 DAGLAASIFHFGEYTVRDVKEALR 265 >UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Opitutaceae RepID=HIS4_OPITP Length = 243 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 80/237 (33%), Positives = 123/237 (51%), Gaps = 13/237 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ G VRL QG ++ Y +P + A G+E +H+VDL GA + Sbjct: 3 IYPAIDIKGGRCVRLTQGRAEQETIYAQNPADVAMQFRAAGSEWVHVVDLDGAFAGEPQN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ +VA V + VQ GGG+R+ V L GV+RVV+G+ A +S+ V + FG Sbjct: 63 LAAVQAIVA-VGMKVQFGGGLRTRAAVERALALGVSRVVLGTRAAESESFVGELVQAFG- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D + N +VAV GW + +S L +G+ ++ TDI DG L G Sbjct: 121 DKIAVGIDAK-----NGKVAVKGWVATADLSTLVLARRMDTLGVATLIHTDIGTDGMLTG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-----RGTGVRGVIVGRALLEGKF 233 N++ E +C+ +SGG+ DDV L R + GVIVG+AL E + Sbjct: 176 PNLAAQEALCSAVKS-RVIASGGVSRRDDVVNLAKLAQRHANLDGVIVGKALYERRV 231 >UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hisF n=55 Tax=cellular organisms RepID=HIS6_THEEB Length = 281 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 68/222 (30%), Positives = 107/222 (48%), Gaps = 9/222 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ G VV+ ++ RD G DP+ Q Y A GA+ L +D+T + Sbjct: 7 ILPCLDVKAGRVVKGV--NFVNLRDAG-DPVELAQAYNAAGADELVFLDITATHEERNIL 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V +P+ VGGG++S + LL AG +V + S AV+ D+V +RFGA Sbjct: 64 IDVVYRTADQVFIPLTVGGGIQSLTMIKDLLRAGADKVSLNSAAVRQPDLVNQASDRFGA 123 Query: 122 DALVLALDVRIDEQG-----NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +V+A+D R + QV V G +E +G+ G +L T + D Sbjct: 124 QCIVVAIDARREPDCAPDQPRWQVYVRGGREATGLDAVAWAVEMAKRGAGELLVTSMDAD 183 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG 218 GT AG ++ L + R ++ +SGG G + + A G Sbjct: 184 GTQAGYDLELTRAIAERV-EIPVIASGGAGTCEHIRAALVEG 224 >UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U8M5_HYDS0 Length = 234 Score = 227 bits (579), Expect = 3e-58, Method: Composition-based stats. Identities = 75/236 (31%), Positives = 132/236 (55%), Gaps = 9/236 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ DG VVRL +G + + Y +P+ + + + G +H+VDL GAK + Sbjct: 4 FIIPAIDIKDGAVVRLKEGKFENVKVYRQNPIDQFKLFVDLGFTRIHIVDLDGAKVGIPK 63 Query: 61 QIPLIKTLVAG-VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + L++ ++ + V++GGG+RS E AL E G ++VG+ AVK ++ E + Sbjct: 64 NLKLLEDMLKQKNDAKVEIGGGIRSLETAKALFEIGADYIIVGTLAVKDKEEFIRLLELY 123 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 D ++L++D + N +VA+ GW+E S +S + Y ++ L T+I+ DGTL Sbjct: 124 -KDRIILSVDAK-----NGKVAIGGWEEESSISPCDMARIYDNYPIESYLYTNINIDGTL 177 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 G +++ Y++ + +SGG+ ++DV L+ V GV+VG+A+ E K + Sbjct: 178 TGVDINPYKDF-KKCTTKPIIASGGVASLEDVIKLKTV-VNGVVVGKAIYENKIDI 231 >UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hisF n=420 Tax=cellular organisms RepID=HIS6_BRUMB Length = 261 Score = 226 bits (576), Expect = 6e-58, Method: Composition-based stats. Identities = 70/244 (28%), Positives = 122/244 (50%), Gaps = 9/244 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP LD+ DG VV+ ++ D G DP+ + Y A GA+ L +D+T + D + Sbjct: 7 VIPCLDVKDGRVVKGV--NFVDLIDAG-DPVEAARAYDAAGADELCFLDITASSDNRETI 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ +P+ VGGGVR D+ LL AG +V + + AVK+ + V ++FG Sbjct: 64 FDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFGN 123 Query: 122 DALVLALDVRI----DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+A+D + E + ++ G ++ +G+ + + + +G +L T + RDG Sbjct: 124 QCIVVAIDAKKVSGAGENDHWEIFTHGGRQPTGIDAVEFAQKVVDLGAGEILLTSMDRDG 183 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVK 236 T AG +V+L V A + +SGG+G +D + A +R V+ G +T+ Sbjct: 184 TKAGYDVALTRAV-ADSVRAPVIASGGVGTLDHLVAGIRDGHATAVLAASIFHFGTYTIG 242 Query: 237 EAIA 240 EA Sbjct: 243 EAKR 246 >UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=HIS42_PHOLL Length = 258 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 79/252 (31%), Positives = 131/252 (51%), Gaps = 14/252 (5%) Query: 2 IIPALDLIDG------TVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 I P++D++DG + +RL +G+ R P + GA+ +H+VDL A Sbjct: 9 IFPSVDIVDGIAMTSNSAIRLTRGESSTLRRPLGTPAEVALAWQNAGAKWIHVVDLDAA- 67 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 LI ++A V++ VQV GG+R E + +L G RV +G+ A+++ D Sbjct: 68 SGRGSNSHLIADVLAAVDINVQVCGGIRDETILRKVLATGCQRVNLGTAALENPDWCAQA 127 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +G D + +ALDV+ +G Q+A GW + G +L L+E G + + TD+ R Sbjct: 128 IAEYG-DKIAIALDVKSTSEG-YQLATHGWNVSKG-NLWDLLERLDKQGCQRYVVTDVER 184 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGK 232 G ++ N +L +EVCA+ + GG+ +DD+ AL GV G I+G+AL GK Sbjct: 185 GGMMSSPNFTLLQEVCAKTSS-PVIAGGGVSSLDDLRALADLSTIGVEGAILGQALHIGK 243 Query: 233 FTVKEAIACWQN 244 +++A+A Q+ Sbjct: 244 VPLEDALAATQS 255 >UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUX9_ALIAD Length = 252 Score = 223 bits (570), Expect = 3e-57, Method: Composition-based stats. Identities = 92/242 (38%), Positives = 131/242 (54%), Gaps = 11/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D++ G VVRL QGDY + Y DP GA LH+VDL A+ Sbjct: 8 VYPAIDILGGEVVRLRQGDYQQVTRYDGDPAGVAGRLCDAGARFLHVVDLDAARSGQSDN 67 Query: 62 IPLIKTLVAGV---NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 ++ +V VQVGGG+R+++ +A LEAGVARVV+G+ AV+ ++V W + Sbjct: 68 ERAVRAIVETAASYGAAVQVGGGIRTKDAIARWLEAGVARVVIGT-AVRQVEVVAEWAQE 126 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 FG LV LD R ++AVSGW E + S+ L VGL L TD+ RDGT Sbjct: 127 FGGHRLVAGLDGRK-----GRLAVSGWLEETEWSIFDLARELAKVGLVQALVTDVERDGT 181 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N+ L + + + +SGGIG IDDV A+R G+ G ++G+AL +G+ + E Sbjct: 182 GEGPNLDL--ALGVQETGLFAIASGGIGSIDDVVAVRRAGLAGAVIGKALHDGRIHLGEL 239 Query: 239 IA 240 Sbjct: 240 FQ 241 >UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hisF n=224 Tax=Bacteria RepID=HIS6_STACT Length = 254 Score = 223 bits (570), Expect = 4e-57, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 120/245 (48%), Gaps = 6/245 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ Q + RD G DP+ Y A+ A+ L +D++ ++ + Sbjct: 6 IIPCLDVKDGRVVKGVQ--FKGLRDIG-DPVALAAYYNAELADELVFLDISRTENGHQMM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + + +P+ +GGG+ S +D++ LL+ G +V + S+A+++ +VK E+FG+ Sbjct: 63 LDIIEETASKLFIPLTIGGGISSTDDISTLLKHGADKVSLNSSALRNPSLVKEASEKFGS 122 Query: 122 DALVLALDVRI-DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +A+D + DE+ + G ++ + + + V +G +L T + DG Sbjct: 123 QCICIAVDAKWEDERNDWFCYTHGGKQPTDIRVLDWVRQVEYLGAGELLVTSMDYDGVKQ 182 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAI 239 G + L ++ + +SGG G+ L + T V + + + T+ Sbjct: 183 GFDHQLLNQINT-VVSIPVIASGGGGNAQHFVDLFQQTNVSAGLAASIFHDKETTIGAVK 241 Query: 240 ACWQN 244 ++ Sbjct: 242 TYLKD 246 >UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZQ4_9SPHI Length = 250 Score = 223 bits (569), Expect = 4e-57, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 139/243 (57%), Gaps = 14/243 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++D VVRL +G+Y Y ++ Y A G E++H++DL GAK Q Sbjct: 3 IIPAIDVLDKKVVRLREGNYDDVTTYDISLEEQIDRYHANGTELVHIIDLNGAKGDFSNQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE---- 117 L ++ + +Q GGGVRS E V L++AGV RV+VG+ A+ + + ++ Sbjct: 63 EYLF-NIIRKTEMKIQYGGGVRSIEKVKELIDAGVFRVIVGTQAITNPEFLEELSTLNEG 121 Query: 118 --RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 ++ AD +V+A+DV ++ + SGW E+S + L + ++ L +G LCTDIS+ Sbjct: 122 KIKY-ADHIVIAIDV-----LDEVIKYSGWLESSPIKLIEYIDKCLALGFYRFLCTDISK 175 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFT 234 DG L G+ V LY+++ P + SGGI +DD+ L+ G + +VG+A+ E + + Sbjct: 176 DGKLGGAGVELYKKLLDHSPIIKLIGSGGISSMDDIRKLQELGRMESCVVGKAIYENRIS 235 Query: 235 VKE 237 ++E Sbjct: 236 IEE 238 >UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hisF n=67 Tax=Bacteria RepID=HIS6_SYNY3 Length = 261 Score = 222 bits (566), Expect = 9e-57, Method: Composition-based stats. Identities = 65/220 (29%), Positives = 106/220 (48%), Gaps = 7/220 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ G VV+ ++ +D G DP+ + Y GA+ L +D+T + Sbjct: 7 ILPCLDVNAGRVVKGI--NFVDLQDAG-DPVELARAYNEAGADELVFLDITATHEQRDTI 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V +P+ VGGG+ + E + LL AG +V V S+AV+ D + +RFG Sbjct: 64 IDVVYRTAEEVFIPLTVGGGISTLEHIKNLLRAGADKVSVNSSAVRDPDFISRASDRFGR 123 Query: 122 DALVLALDVRIDEQGN---KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 +V+A+D R + V V G +EN+G+ E G +L T + DGT Sbjct: 124 QCIVVAIDARRRLDADNPGWDVYVRGGRENTGLDAIAWAEEVAKRGAGELLVTSMDGDGT 183 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG 218 AG +++L + R ++ +SGG G+ V G Sbjct: 184 QAGYDLALTAAIAERV-EIPVIASGGAGNCQHVYEAFTEG 222 >UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B860_THEAS Length = 232 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 80/239 (33%), Positives = 121/239 (50%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL G VVRL G + Y P +A G H+VDL GAK Sbjct: 3 IYPAVDLYGGKVVRLTGGRFQDATVYPTSPGEMALLFAQAGVRWAHVVDLEGAKTGRPVH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + VQ GGG+RS + V L AG RV++GS V FG Sbjct: 63 LWALEAFAGA-GLKVQFGGGIRSIQSVRDALSAGATRVMMGSALFDRSVDVVEAHRLFGP 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A++ A+D R +V+V GW + + + +++ +E VG L TD RDGTL+G Sbjct: 122 -AILPAVDHR-----GWRVSVKGWTQGTDIPVDRALENLSRVGFSLFLVTDGDRDGTLSG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ Y ++CARY ++GGIG++ + LR G G ++G+AL EG +++EA+ Sbjct: 176 PDLEGYRKICARY---GIIAAGGIGELGHLRGLRNAGAAGAVLGKALYEGAISIEEAMR 231 >UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=1 Tax=Silicibacter lacuscaerulensis ITI-1157 RepID=D0CY30_9RHOB Length = 282 Score = 220 bits (562), Expect = 3e-56, Method: Composition-based stats. Identities = 71/245 (28%), Positives = 117/245 (47%), Gaps = 9/245 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + P ++L +G V L +G + + DP+ Q +AA GAE +HL D A + Sbjct: 38 VYPTMELQNGRCVTLDKGRLDEPMIWHVDPVETAQGWAAAGAEWMHLTDFD-AIEGRDTN 96 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ ++ +PVQ+ GG RS E V ++ G R+V+G+ A + + K + + Sbjct: 97 SALVEQIIRSAELPVQLAGGFRSREQVERWIDKGAGRIVIGTLAARDPHLFKELAKLY-P 155 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D +VLA+DV V GW+ S S E +E + L +L TDI D Sbjct: 156 DQIVLAVDVWQ-----GYVMTDGWRTQSAFSPEAFIEAFADAPLAAILVTDIDSDMVDVE 210 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIA 240 + + L + A + + +SG + DD++ L + GV+VGRAL + EA+A Sbjct: 211 AQLGLISGLAA-HSRTPVIASGVVRSSDDISRLAYIPNISGVLVGRALFRKTVDLSEALA 269 Query: 241 CWQNA 245 + A Sbjct: 270 VARTA 274 >UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=HIS6_THEYD Length = 278 Score = 219 bits (558), Expect = 9e-56, Method: Composition-based stats. Identities = 59/238 (24%), Positives = 106/238 (44%), Gaps = 30/238 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ RD G DP+ Y + A+ L +D+T + + K Sbjct: 6 IIPCLDVKDGRVVKGV--NFLNLRDAG-DPVENALYYNEEEADELVFLDVTASHEKRKII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ + V +P+ VGGG++S +D+ LL AG +V + +TAVK ++ RFG+ Sbjct: 63 IDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRFGS 122 Query: 122 DALVLALDVRI--------------------------DEQGNKQVAVSGWQENSGVSLEQ 155 +V+A+D + E ++ G + + Sbjct: 123 QCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRPIDAIA 182 Query: 156 LVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 + G +L T + RDGT G ++ L + + + +SGG G ++ + Sbjct: 183 WAKKMEEFGAGEILLTSMDRDGTKEGYDIELTRAI-SEAVSIPVIASGGAGTLEHLYE 239 >UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Archaeoglobaceae RepID=HIS4_ARCFU Length = 238 Score = 218 bits (556), Expect = 1e-55, Method: Composition-based stats. Identities = 76/240 (31%), Positives = 122/240 (50%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL DG VVRL QG + +P+ + + GA+VLH++DL+GA R Sbjct: 4 VIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRLRH 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + VQVGGG+R L E GV RV+ G+ AV+ + ++ + +++ Sbjct: 64 EEIIAEIAKMA--EVQVGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKWKG 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++A+D + +VAV GW+E ++ QL E Y + + L T+I +G ++G Sbjct: 122 -RVMVAIDSKK-----GRVAVKGWKEVVELTPVQLAELYDDLDVS-FLYTNIDVEGLVSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 EEV +GGI I+D+ + G GV++G AL K +EAI Sbjct: 175 IERERIEEVVKSLRN-PVYVAGGISSIEDIRFAKRVGAAGVVIGSALYTKKLKFEEAIKV 233 >UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 n=15 Tax=Rhodobacterales RepID=HIS41_SILST Length = 247 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 71/244 (29%), Positives = 117/244 (47%), Gaps = 9/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI P ++L+DG V L +G+ + DP+ + +A GAE +HL D A Sbjct: 2 MIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFN-ALQGDSS 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L++ L+ +P+Q+GGG+RS E +E GV RVV+G+ A V ++ Sbjct: 61 NQDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELA-KYY 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +VLA+DV QV GW+++ + E V+ + +L TDI D + Sbjct: 120 PDQVVLAVDVWQ-----GQVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVTDIDSDMSDL 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAI 239 + + L + + +SG + DD++ L+ + G +VGRAL T++EA+ Sbjct: 175 DAQLGLISGLAEQA-HSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAM 233 Query: 240 ACWQ 243 Q Sbjct: 234 ETAQ 237 >UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Thauera sp. MZ1T RepID=C4ZLR4_THASP Length = 226 Score = 217 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 65/243 (26%), Positives = 110/243 (45%), Gaps = 31/243 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ + RD G DP+ + Y Q Sbjct: 6 IIPCLDVKSGRVVKGV--NFVELRDAG-DPVEIARRYDEQ-------------------- 42 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + V +P+ VGGGVR EDV LL AG +V + + AV + +V + G+ Sbjct: 43 ------VAEQVFIPLTVGGGVRVVEDVRRLLNAGADKVSMNTAAVNNPQLVFEAASKVGS 96 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+D + G +V G + N+G+ + +G +L T + RDGT +G Sbjct: 97 QCIVVAIDAKQTAPGKWEVFTHGGRNNTGLDAIEWARKVESLGAGEILLTSMDRDGTKSG 156 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 +++L V + ++ +SGG+G ++ +A G V+ G+ TV+EA Sbjct: 157 FDLALTRAV-SDAVRIPVIASGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHTVREAKE 215 Query: 241 CWQ 243 + Sbjct: 216 LMR 218 >UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ6_9ACTN Length = 247 Score = 216 bits (551), Expect = 6e-55, Method: Composition-based stats. Identities = 88/250 (35%), Positives = 133/250 (53%), Gaps = 14/250 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK- 59 ++ PA+DLI G VVRL +GD + + Y +DP+ + +A QGA +H+VDL+ A + Sbjct: 2 ILFPAIDLIGGKVVRLERGDRSRCKVYSDDPVAVARSFAEQGASWVHVVDLSSAFGEDED 61 Query: 60 ---RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 IK + + V VGGGVRS + L G R+ +G+ V + Sbjct: 62 TCAANSAAIKAICGVDGLSVDVGGGVRSLARIDELAGYGARRIALGTVLVTEPGFAEVAA 121 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 + FG + LV + R + QV V+GW++ +GV+L+ V +G KH++ TDI+RD Sbjct: 122 QGFG-ELLVADIAAR-----DGQVKVNGWRDGAGVALDDAVAQLSELGFKHLVYTDIARD 175 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKF 233 G G +V+ Y V A +SGGI +DD+ AL G + G I GRAL EG F Sbjct: 176 GMQTGIDVAAYRHV-AEVAGFPVVASGGISALDDIRALAAVGEGAIEGAITGRALYEGNF 234 Query: 234 TVKEAIACWQ 243 T+ +A+A + Sbjct: 235 TLAQALAAAR 244 >UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sp. AT1b RepID=C4L175_EXISA Length = 237 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 78/239 (32%), Positives = 133/239 (55%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+DLI G +VRL +GD+ + YG DP L+ + + ++HL+DL GAK R Sbjct: 3 LLPAIDLIGGKIVRLTEGDFSTEEQYG-DPYELLKAWQGK-VPMIHLIDLEGAKAGEPRH 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + VQ GGG+RSE + A++E G RV++G+ A D + E++G Sbjct: 61 LDVV-RYAKSLGFLVQTGGGIRSEASLDAVMETGADRVLLGTKAFTDPDFLDKAIEKYG- 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +ALD + +VA++GWQE + + + + + G++ +L TDI DG L G Sbjct: 119 KRVAVALDAY-----DGKVAINGWQEATKLDDISVAQDLVKRGIETILYTDIGSDGKLNG 173 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 NV+ + + + V +SGG+ +DV L+ + +VG+ALL GK +++E I Sbjct: 174 PNVTRMKALR-QIVNVTLIASGGVTTEEDVKELKMAKIDEAVVGKALLSGKVSIEELIE 231 >UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI6_KANKD Length = 265 Score = 214 bits (545), Expect = 3e-54, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 108/249 (43%), Gaps = 10/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ G VV+ ++ +D G DP+ Y QGA+ + +D+ + Sbjct: 9 VIVCLDVAHGRVVKGV--NFKGLQDMG-DPVELAIRYQEQGADEIIFLDIKATLEQRANA 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + +++P VGGG+ + DVA L AG +V + S AVK D+V + FG+ Sbjct: 66 LEVVTRVAENLSIPFTVGGGLNTYADVAQFLNAGADKVALNSAAVKHPDLVDEIAKGFGS 125 Query: 122 DALVLALDV------RIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +V+A+D+ + +V ++G + ++ Q + G +L T + R Sbjct: 126 QCVVVAVDLNQEQDQKTQGSSEYEVYINGGHTLTDLNAMQWLTEIEQRGAGEILLTAMHR 185 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGT G + L +V + + +SGG G + G+FTV Sbjct: 186 DGTGFGFDNELMSQVSKKL-GIQVIASGGASKPAHFTDTFLAGSDAALAAGMFHRGEFTV 244 Query: 236 KEAIACWQN 244 + N Sbjct: 245 GQVKQELLN 253 >UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HIS4_RUBXD Length = 243 Score = 214 bits (545), Expect = 3e-54, Method: Composition-based stats. Identities = 103/242 (42%), Positives = 141/242 (58%), Gaps = 10/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL G VRL QGD+G++R Y DP+ R +++ +GA LH+VDL GA++ Sbjct: 8 VVFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPV 67 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ LI+ + VP+QVGGG+R+ EDV A AG ARVVVG+ AV +D E G Sbjct: 68 QLALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELG 127 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 AD LV+A+D R VA GWQ SGV +L G++ VL TDISRDGT Sbjct: 128 AD-LVVAVDAR-----EGVVATHGWQRQSGVGAAELAGELAAEGVRAVLFTDISRDGTGE 181 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAI 239 G+ + EV + +SGG+ D+ AL R GV G +VG AL EG+ T++E + Sbjct: 182 GAALERTAEVAG---IIPTIASGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLEELL 238 Query: 240 AC 241 A Sbjct: 239 AA 240 >UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M910_CALMQ Length = 254 Score = 213 bits (543), Expect = 5e-54, Method: Composition-based stats. Identities = 60/235 (25%), Positives = 106/235 (45%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP +D+ VV+ ++ R G DP+ Y +GA+ L L+D+T Sbjct: 11 IIPCMDVDADIVVKGV--NFEGLRVMG-DPVELASRYEEEGADELFLLDITATVQGRSTF 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + A V++P+ VGGG+R ED A +AG +V + + AVK +V +G+ Sbjct: 68 LETVRNVAAAVSIPLGVGGGIRGMEDADAAFKAGADKVSINTAAVKDPSIVAKLSREYGS 127 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V+A+D R +V + G + + ++ T +G +L T I DGT AG Sbjct: 128 QSVVVAIDTRRINN-EWRVFIMGGRRETLLNAVDWARTVEELGAGELLVTSIDADGTRAG 186 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 ++ LY + A + +SGG G+ + + G + Sbjct: 187 YDIELYRRL-ADAVNIPVIASGGAGEPSHFLEVLKY-ADAALAASVFHMGVINIS 239 >UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Arcobacter butzleri RM4018 RepID=A8ESN1_ARCB4 Length = 256 Score = 212 bits (542), Expect = 5e-54, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 114/235 (48%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L G L++ + K+ Y DP+ ++ + + + L +D+ + + + Sbjct: 7 VIPCLLLHKGG---LYKTEKFKKPTYIGDPINAIKIFNEKEVDELMFIDIDASVEDREPN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ + + +P+ GGGV++ E + + GV +V + S A+ + +++K FG Sbjct: 64 YKMIEDIASECFMPLCYGGGVKNIEQMKKIYALGVEKVSISSQAIINPNLIKEAARLFGN 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++++ +D++ D GNK++ ++ ++N+ ++ ++ +G ++ DG + G Sbjct: 124 QSVIVTIDIKKDFWGNKKIFINNGKKNTKLNPIDFIKQVESLGAGEIVINSCDNDGIMKG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRAL-LEGKFT 234 ++ L +E+ +V + GG G+++ + + V V G +G Sbjct: 184 YDIELLKEI-KENTKVPIIALGGAGNLNHIKDVFESSKVDAVACGSMFVYQGPLK 237 >UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hisF n=3 Tax=Bacteria RepID=C8PKX5_9PROT Length = 306 Score = 212 bits (541), Expect = 7e-54, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 115/296 (38%), Gaps = 59/296 (19%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ D G DP+ + Y +GA+ L +D+T + Sbjct: 8 IIPCLDVKDGRVVKGV--NFVGLVDAG-DPVEIAKRYNEEGADELCFLDITASHLGRDTI 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ + + +P+ VGGG+R+ +D++ LL G ++ + S A+K+ +++ +FG+ Sbjct: 65 VDVVERVARELFIPLTVGGGIRTIDDISRLLNVGCDKISLNSAAIKNPNLIDEAANKFGS 124 Query: 122 DALVLALDVRIDE----------------------------------------------- 134 +V+A+D + + Sbjct: 125 QCVVIAIDAKRNSIEISRGDLYGEARNSNGDLHGGMRNPDTNLGSEARNFGEILRGAQDE 184 Query: 135 --QGNKQ-----VAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLY 187 GN + V ++G + ++G + G +L T + DG G ++L Sbjct: 185 ILTGNGELCGYSVFINGGRLDTGRDALAWAKEAQERGAGEILLTSMDCDGVKNGFELNLT 244 Query: 188 EEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQ 243 A + +SGG G ++ G + + +K A Q Sbjct: 245 RIFSAL--DIPVIASGGAGKMEHFKDAFLAGADACLAASIFHFREIEIKALKAYLQ 298 Score = 43.5 bits (102), Expect = 0.006, Method: Composition-based stats. Identities = 21/100 (21%), Positives = 36/100 (36%), Gaps = 4/100 (4%) Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A ++ LDV+ V ++G ++ + Y G + DI+ Sbjct: 5 AKRIIPCLDVKDGRVVKGVNFV--GLVDAG-DPVEIAKRYNEEGADELCFLDITASHLGR 61 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVR 220 + V + E V + GGI IDD++ L G Sbjct: 62 DTIVDVVERVAREL-FIPLTVGGGIRTIDDISRLLNVGCD 100 >UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winogradskyi Nb-255 RepID=Q3SPZ7_NITWN Length = 258 Score = 212 bits (540), Expect = 9e-54, Method: Composition-based stats. Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 3/228 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L DG +V+ + + +R G +P+ + Y G + L ++D+ + R Sbjct: 6 LIPKFLLRDGRLVK-YTCFFDNERIAG-NPVTTAKVYNDYGVDELIVLDIVPSAASRARV 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + + +P VGGGV++ EDV ALL AG +V + S AV+ + V+ FG Sbjct: 64 EDIIGRMSEEIFMPFTVGGGVKTAEDVNALLRAGADKVSINSEAVRRPEFVREAARTFGD 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D + + V + G +E+ + + + +L + I RDGT+ G Sbjct: 124 QCITVSIDYKRIGSHHASVYIDGGREHVALDPVEWALRCEDLHCGEILMSSIDRDGTMQG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 ++ + + R V SGG G + G V + L Sbjct: 184 YDLEMINTLTKRL-GVPMIVSGGCGSLQHAIDALEAGASAVAISSMFL 230 >UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SCV5_HAHCH Length = 255 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 57/247 (23%), Positives = 106/247 (42%), Gaps = 8/247 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK-- 59 IIP L L G +V+ Q + DP+ + Y AQ A+ L +D+ + + Sbjct: 6 IIPMLLLSQGRMVKGKQFSAFRDT---GDPVSAARIYNAQFADELVFLDVDANRQGSDFE 62 Query: 60 RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + LI + + +P+ VGGGV S E V L+++G +VV+ + A+++ ++ F Sbjct: 63 QLLNLIDKVSSECFMPLSVGGGVNSVEQVRRLVQSGADKVVITTAALENPGLINDASAIF 122 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G +V+ LDV+ E G ++ + + LE+ + G + + RDG + Sbjct: 123 GRQCIVVGLDVKR-EDGAYRLYSHCGRHKTERELEEFIRDMTQRGAGEFIVNAVDRDGMM 181 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTVKEA 238 G ++ + + ++GG G + AA + V+ G A Sbjct: 182 QGYDLEMI-KCAKAVTDRPVLAAGGAGTFAHLTAAFQEANADAVVCASIFHFGDNNPIRA 240 Query: 239 IACWQNA 245 + NA Sbjct: 241 RSHLLNA 247 >UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJR2_DESAA Length = 262 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 60/216 (27%), Positives = 101/216 (46%), Gaps = 9/216 (4%) Query: 12 TVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAG 71 +V + +G + G DP+ + + Y AQ A+ L +DL + + +I Sbjct: 22 RMVLVTTVGFGPSTEIG-DPVSQAKIYQAQAADELVFLDLDASIEHRDALTDIIAKAAEE 80 Query: 72 VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVR 131 + +P+ VGGGVRS ED LL G +V + + A++ +++ + FGA +V+++D + Sbjct: 81 IFMPITVGGGVRSVEDCRRLLNHGADKVSINTGAMEIPELINQGSDMFGAQCIVVSIDYK 140 Query: 132 IDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVC 191 G +V G + ++G+ G +L T I RDGT G N+ L +V Sbjct: 141 KHPNGAYEVFTRGGKSSTGLDPVAWAVEAQHRGAGEILLTSIDRDGTRKGLNLELTAKV- 199 Query: 192 ARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 A + +SGG G L V G +VG+A Sbjct: 200 AGAVDIPVITSGGCG-------LASHFVDGFLVGKA 228 >UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hisF n=7 Tax=cellular organisms RepID=HIS6_THEP1 Length = 254 Score = 212 bits (540), Expect = 1e-53, Method: Composition-based stats. Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 5/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ DG VV+ ++ RD DP+ + Y+ G + L +D+T + + K Sbjct: 6 IIACLDVKDGRVVKGT--NFENLRD-SGDPVELGKFYSEIGIDELVFLDITASVEKRKTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L++ + +++P VGGG+ E + L+ G +V + + AV+ ++ FG+ Sbjct: 63 LELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVEDPSLITKIARTFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A+V+A+D + G V ++N+G+ L V G +L T I RDGT AG Sbjct: 123 QAVVVAIDAKKV-DGEFVVFTYSGKKNTGILLRDWVVEVERRGAGEILLTSIDRDGTKAG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + + V + +SGG G ++ G + + V+E Sbjct: 182 YDTEMIRFVRP-LTTLPIIASGGAGKMEHFLEAFLAGADAALAASVFHFREIDVRELKEY 240 Query: 242 WQ 243 + Sbjct: 241 LK 242 >UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hisF n=76 Tax=Bacteria RepID=HIS6_MYCBP Length = 267 Score = 211 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 69/247 (27%), Positives = 116/247 (46%), Gaps = 10/247 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP LD+ DG VV+ ++ RD G DP+ Y A+GA+ L +D+T + Sbjct: 17 VIPCLDVDDGRVVKGV--NFENLRDAG-DPVELAAVYDAEGADELTFLDVTASSSGRATM 73 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ V +P+ VGGGVR+ DV +LL AG +V V + A+ D++ +FG+ Sbjct: 74 LEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFGS 133 Query: 122 DALVLALDVRIDEQG------NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +VL++D R G +V G + +G+ Q +G+ +L + Sbjct: 134 QCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDA 193 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGT AG +++L V A V +SGG G ++ A G V+ + T+ Sbjct: 194 DGTKAGFDLALLRAVRAAVT-VPVIASGGAGAVEHFAPAVAAGADAVLAASVFHFRELTI 252 Query: 236 KEAIACW 242 + A Sbjct: 253 GQVKAAL 259 >UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Synechococcus sp. CC9311 RepID=Q0IDQ9_SYNS3 Length = 255 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 60/244 (24%), Positives = 115/244 (47%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ GT+++ Q R G DP+ + Y+ GA+ L +D+ + Sbjct: 6 IIPRLDIKSGTLIKGVQ--MEGWRKVG-DPILAAKRYSEYGADELLFMDVVASLYERNTL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + + V +PV VGGG+R +DV LL G +V V + A+ +++ +R+G+ Sbjct: 63 HEIVEQVCSNVFIPVTVGGGIRKIKDVETLLSRGADKVSVNTGALLKPELINEISDRYGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A VL ++ + + + + SG + + V+ G ++ T I +DG G Sbjct: 123 QATVLTVECLKCGEKSWEALTDNGRNRSGREVIEWVKEAENRGAGEIVLTSIDQDGRGYG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ L ++ ++ + +SGG G + L + T V G + +AL K + E Sbjct: 183 FDIDLV-DIVSQAVNIPIIASGGFGKPSHIVELIKSTDVSGAAIAQALHWEKVSFSEIRD 241 Query: 241 CWQN 244 ++ Sbjct: 242 SLRD 245 >UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8V9_IGNH4 Length = 235 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 69/241 (28%), Positives = 123/241 (51%), Gaps = 11/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + P++D+ +G V+ +G G D G DP+ + +A +GA+ LH+VDL GA+ Sbjct: 3 VFPSIDVSEGRAVKRVRGVKGTGLDLG-DPVKWAEFWALEGAKGLHVVDLDGAEAGKPIN 61 Query: 62 IPLIKTL---VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + +I + + VQV GG+R E + + V+GS A K + ++ E Sbjct: 62 VEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPK--ADAFVIGSRAHKDPEFLEVASEA 119 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 GAD +++A+D++ +V+V GW+E V L++ +E + + L T + +GT Sbjct: 120 VGADKVIVAIDLK-----GGKVSVEGWKEEIPVGLKEALEKFKGRSFRGFLYTYVDTEGT 174 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 + G +VS + + YP + +GG+G + V L G V++G AL GK +K+ Sbjct: 175 MEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDL 234 Query: 239 I 239 + Sbjct: 235 V 235 >UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococcoides RepID=A5FQU7_DEHSB Length = 268 Score = 209 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 113/242 (46%), Gaps = 11/242 (4%) Query: 2 IIPALDLIDGTVVRLHQG-DYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIP LD+ DG VV+ + D R DP Y+ QGA+ L +D+T + + Sbjct: 6 IIPCLDVKDGRVVKEIKFTDMADAR----DPAEAAFVYSKQGADELAFLDITATIENSSI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +K +++ ++P+ GGG+R+ +D+ L GV+ V + + ++Q+ ++ RFG Sbjct: 62 HTDWVKKIISKTSLPLIAGGGIRNLQDIENLFTLGVSNVALNTITPQNQEFIRKAVARFG 121 Query: 121 ADALVLALDVRIDEQGNK----QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 ++ +++A+D + GN + + + + L + +G +L T D Sbjct: 122 SERIIVAIDGIKNPPGNGHPRLETVMPNGDDTHNLELVDWAKQVEALGAGAILLTSKDTD 181 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTV 235 GT G ++ + V R + +SGG G ++D+ AA+ + V+ G + Sbjct: 182 GTKDGFDMEMIRSV-TRAVSIPVIASGGAGKLEDMYAAIIEGKAQAVLAASVFHSGIINI 240 Query: 236 KE 237 E Sbjct: 241 SE 242 >UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW5_HODCD Length = 241 Score = 209 bits (533), Expect = 7e-53, Method: Composition-based stats. Identities = 72/237 (30%), Positives = 112/237 (47%), Gaps = 10/237 (4%) Query: 5 ALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPL 64 ++D+ +G VRL +G R Y + PL ++ + Q +++H+VDL GA + + Sbjct: 6 SIDVKNGECVRLCRGQMADCRVYASSPLEAVRKFNLQCCDLVHIVDLDGAVCGSPQNWRS 65 Query: 65 IKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADAL 124 I + VQVGGGVR+ D LE G ++VV+G++A+ + V + + Sbjct: 66 ILEAARQLKGCVQVGGGVRTLADAKLYLEGGASKVVLGTSAIADMEFVCHVSWLYPG-RV 124 Query: 125 VLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNV 184 + +D + VA GW S V +QLV + ++ TDI+RDGTL G N Sbjct: 125 CVGVDT-----FGELVATDGWTAVSCVRCDQLVPKLEAARVSCLIWTDINRDGTLQGVNF 179 Query: 185 SLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKEA 238 + V A V SGG+ D+ L + GVI G+AL E T + A Sbjct: 180 DALDRVLA-ASAVPVIVSGGVATALDLIKLHNLYADKLAGVICGKALYERTLTARFA 235 >UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Prochlorococcus marinus RepID=A2C5V2_PROM3 Length = 500 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 56/237 (23%), Positives = 107/237 (45%), Gaps = 5/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ +++ + + R G DPL + YA G + L +D + Sbjct: 19 IIARLDVKGNKIIKGVR--FEGLRVIG-DPLDMARKYAKAGIDELLYIDAVASLYGRNSL 75 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++K+ + V +P+ GGG+R+ ED LL G ++ + + A++ ++ G+ Sbjct: 76 IEVLKSTSSEVFIPITAGGGIRNLEDAKLLLSNGADKIAINTAALECPQLISELSNTLGS 135 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++ R + +E SG+ + + +E +G +L T + +DGT Sbjct: 136 QCVVVSIQARASSSSSWDAMKESGREKSGIDVIKWIENVQLLGAGEILLTSVDQDGTCIK 195 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTVKE 237 + L ++V ++ SGG D + V AL + + V +G AL K V + Sbjct: 196 PDEILIQKVLP-ILKLPLIVSGGFSDPNQVYQALTNSRISAVAIGAALHYQKTNVSD 251 >UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Bacteria RepID=C5BRY3_TERTT Length = 259 Score = 207 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 62/242 (25%), Positives = 111/242 (45%), Gaps = 7/242 (2%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQI 62 I LD+ +++ R G DP + Y QGA+ L +DL + + Sbjct: 12 IARLDVKGDQLIKAIH--LEGLRVVG-DPQIYAKRYYEQGADELLYIDLVASLYGRNKLK 68 Query: 63 PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGAD 122 ++ + +P+ VGGG+RS EDV LL AG +V + + AV + +++ RFG+ Sbjct: 69 DIVSRTAQDIFIPLTVGGGIRSVEDVTELLAAGADKVAINTAAVANPALIEQVALRFGSQ 128 Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 +VL+++ + + +V +E+SG + + + G +L T I ++GT G Sbjct: 129 CMVLSIEAKRLGEDRWEVYTDCARESSGRDVIAWAKEAVERGAGEILLTSIDQEGTRKGF 188 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACW 242 + +L V A +V +SGG G + + A+ G I A + +E IA Sbjct: 189 DTALTAAV-AETVRVPVIASGGYGQPEHINAITHQGSANAI---AFADALHFERETIASL 244 Query: 243 QN 244 ++ Sbjct: 245 KS 246 >UniRef50_P72139 Putative imidazole glycerol phosphate synthase subunit hisF2 n=9 Tax=cellular organisms RepID=HIS62_PSEAE Length = 251 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 48/228 (21%), Positives = 98/228 (42%), Gaps = 4/228 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L D +V+ + K+ Y DP+ ++ + + + L L+D+ ++ + Sbjct: 6 VIPCLLLKDRGLVKTVK---FKEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQEPN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI + +P+ GGG+++ E + GV +V + + A+ +++ ++FG+ Sbjct: 63 YELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V ++D R G V + S + + G+ + I RDG G Sbjct: 123 QSVVGSIDCRKGFWGGHSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSIDRDGVQKG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 + +L E + + V + GG G I D+ L + +L Sbjct: 183 FDNALVENIASNV-HVPVIACGGAGSIADLIDLFERTCVSAVAAGSLF 229 >UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7I5_9DELT Length = 289 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 103/233 (44%), Gaps = 5/233 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +V+ + R G P + Y GA+ L D + Sbjct: 5 IIPRLDIKGPNLVKGIH--FEGLRVLGK-PEDFARHYYENGADELFFQDAVASLYDRNSL 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++K + + +P+ VGGG+RS +D+ A+L AG +V + + A+K ++++ FG+ Sbjct: 62 HDIVKRTSSEIFIPLCVGGGLRSVDDIRAVLRAGADKVAINTEAIKRPELIREASVAFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V++++ G + V +E +GV+ + + +G ++ T I ++GT G Sbjct: 122 STIVVSIEAIRRANGEWEALVEYGRETTGVNAVEWAKRACELGAGELMITSIDQEGTGKG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKF 233 ++ L + A V + GG G D A + G V + L Sbjct: 182 YDIELTRAI-ASAVSVPVIAGGGCGSPADAANVITQGRADAVSMASVLHYKTI 233 >UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC 17748 RepID=C4FS06_9FIRM Length = 256 Score = 206 bits (525), Expect = 6e-52, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 109/249 (43%), Gaps = 9/249 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L + +G V G + DP+ + Y QGA+ L L+D+T + K Sbjct: 6 IIPCLGVANGRV---QNGVQFRDMVDAGDPVECAERYEIQGADELVLLDITATTEARKTF 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ V +P+ VGGG+ S ED+ L++AG +V + + A+ + ++ ++FG Sbjct: 63 TDIVLNASDKVFMPLTVGGGITSVEDMTQLMKAGADKVSINTAALSNPSLITEGAKKFGN 122 Query: 122 DALVLALDVRIDEQGN-KQVAVSGWQENSG---VSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+ LDV+ + G + G + + + + G +L T I R G Sbjct: 123 QGIVVCLDVKYNPFEKMWYAYGHGTSNDPGAQCKNALEWAKEAVDRGAGELLVTSIDRHG 182 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVK 236 T G ++ LY+ + A V + GG G+I L T V G + L T+K Sbjct: 183 TGLGFDIELYQAL-AEVVDVPVTAFGGAGNIQHFVDLFTKTNVTGALASALLHNKVLTIK 241 Query: 237 EAIACWQNA 245 + A Sbjct: 242 DIKKALHAA 250 >UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Proteobacteria RepID=A6T0B3_JANMA Length = 253 Score = 206 bits (524), Expect = 7e-52, Method: Composition-based stats. Identities = 52/227 (22%), Positives = 105/227 (46%), Gaps = 5/227 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P L + G +V+ Q K+ Y DP+ ++ + + + L L+D+T + Sbjct: 6 VMPCLLMDQGALVKTVQ---FKKPTYIGDPVNAVRIFNQKEVDELLLIDITATTEKRGID 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ LV +P+ GGGV + D+ L G+ ++ + + A+ + ++V+ FG Sbjct: 63 FETLEKLVTECFMPICYGGGVDNLVDMRRLYHLGIEKISLSAAAITNPELVREAAAEFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A+V+ LDV+ + G V + ++ S ++ G +L I +DGT +G Sbjct: 123 QAIVVTLDVKKNLFGKHTVRTHQGKTDTKRSPVEVAREMEQAGAGEILLYSIDKDGTWSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRA 227 ++ L + V R + + GG G++ + A+ G V +G Sbjct: 183 FDLDLIQNV-TRAVGIPVIACGGAGELAHLRSAVNEAGASAVAIGSM 228 Score = 58.1 bits (140), Expect = 3e-07, Method: Composition-based stats. Identities = 28/110 (25%), Positives = 46/110 (41%), Gaps = 9/110 (8%) Query: 2 IIPALDLI----DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 I+ LD+ VR HQG +R P+ ++ GA + L + Sbjct: 125 IVVTLDVKKNLFGKHTVRTHQGKTDTKR----SPVEVAREMEQAGAGEILLYSIDKDGTW 180 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALL-EAGVARVVVGSTAV 106 + + LI+ + V +PV GG + + + EAG + V +GS AV Sbjct: 181 SGFDLDLIQNVTRAVGIPVIACGGAGELAHLRSAVNEAGASAVAIGSMAV 230 >UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hisF n=14 Tax=Bacteria RepID=HIS6_BEUC1 Length = 256 Score = 205 bits (523), Expect = 9e-52, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 114/249 (45%), Gaps = 9/249 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P LD+ G VV+ ++ RD G DP+ + Y A GA+ + +D++ + Sbjct: 7 VVPCLDVDGGRVVKGV--NFLDLRDAG-DPVELARRYDADGADEITFLDVSASTQGRATT 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V VP+ VGGGVR+ DV ALL AG +V V + A+ +++ + +G Sbjct: 64 LEMVSATAEQVFVPLTVGGGVRAVADVEALLRAGADKVGVNTAAIARPELLTEIAQHYGN 123 Query: 122 DALVLALDVRIDEQG-----NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 LVL++D R G +V G + +G+ + G VL I D Sbjct: 124 QVLVLSVDARRCPDGVVTDSGFEVTTHGGRTGTGIDAVEWAAEATSRGAGEVLLNSIDAD 183 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 GT AG +V + E V A +SGG G ++D A G V+ G T+ Sbjct: 184 GTTAGFDVEMIEAVRA-VVDTPLVASGGAGTVEDFVAAARAGADAVLAASVFHYGTLTIS 242 Query: 237 EAIACWQNA 245 E A ++A Sbjct: 243 EVKAALRDA 251 >UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hisF n=36 Tax=cellular organisms RepID=HIS6_HALWD Length = 270 Score = 205 bits (523), Expect = 9e-52, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 104/252 (41%), Gaps = 19/252 (7%) Query: 2 IIPALDLI---DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 IIP +D+ DG ++ Y DP+ + Y GA+ +D+T + Sbjct: 6 IIPCIDVDLDEDGNPAVYTGINFEDLE-YTGDPVEMAKQYNMAGADEFVFLDITASAVGR 64 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + + + + + +P+ VGGG+R+ +D+ + L AG +V + + A+++ +++ Sbjct: 65 ETMLETVSRVADEIFIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALETPELITTGASA 124 Query: 119 FGADALVLALDVRIDEQGNK-------------QVAVSGWQENSGVSLEQLVETYLPVGL 165 FG+ +V+++D R + V G +E +G+ + + V G Sbjct: 125 FGSQCIVISVDARRRFDEQGENYLSVDGESCWFECTVKGGREGTGIDVLEWVTEAETRGA 184 Query: 166 KHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIV 224 + I DGT G ++ L VC +S G G D+ G + Sbjct: 185 GELFINSIDADGTQDGYDIPLTSAVC-DAVSTPVIASSGCGSPADMHEVFTEAGADAGLA 243 Query: 225 GRALLEGKFTVK 236 G+++++ Sbjct: 244 ASIFHFGEYSIE 255 Score = 49.7 bits (118), Expect = 1e-04, Method: Composition-based stats. Identities = 23/111 (20%), Positives = 39/111 (35%), Gaps = 3/111 (2%) Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGV--SLEQLVETYLPVGLKHVLCTDISRDGTL 179 ++ +DV +DE GN V E+ ++ + Y G + DI+ Sbjct: 4 KRIIPCIDVDLDEDGNPAVYTGINFEDLEYTGDPVEMAKQYNMAGADEFVFLDITASAVG 63 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 + + V + GGI DD+ + G V + A LE Sbjct: 64 RETMLETVSRVADEI-FIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALE 113 >UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hisF n=19 Tax=cellular organisms RepID=HIS6_DESAA Length = 260 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 107/249 (42%), Gaps = 10/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ DG + +G K DP+ + Y G + L D+T + + Sbjct: 6 VIVCLDVRDG---KTTKGIKFKGNVDIGDPVDMARVYYEAGCDELVFYDITASHEKRGIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ + + +P VGGG+ S ED+ +L AG ++ V S AVK+ ++ E FG Sbjct: 63 IDVVRRVAETIFIPFSVGGGISSVEDMRDVLLAGAEKISVNSAAVKNPKIITQGAEAFGN 122 Query: 122 DALVLALDVRIDEQ-----GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +VL +DV+ E+ ++ ++G + G+ + +G + I D Sbjct: 123 QCVVLGMDVKKVEKSEKIPSGYEIVINGGRTYMGIDALWWAQEGERLGAGEICLNSIDAD 182 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTV 235 GT G + L + + + +SGG G + L+ ++ + G +T+ Sbjct: 183 GTKEGYELELT-ALISENVNIPVIASGGGGIPQHLGDVLKEGKADAALIASMVHYGTYTI 241 Query: 236 KEAIACWQN 244 E ++ Sbjct: 242 PEIKDHLKS 250 >UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW6_HODCD Length = 264 Score = 203 bits (517), Expect = 4e-51, Method: Composition-based stats. Identities = 64/237 (27%), Positives = 108/237 (45%), Gaps = 6/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP +D+ +G VV+ + + G L Y+ GA+ L +D++ + Sbjct: 9 IIPCMDVKEGHVVKGSK--FCGLVRVGEATL-VANSYSVSGADELCFLDVSASSANRSIL 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I + +P+ VGGGVR +DV LL AG +V + S V S + + ++FG+ Sbjct: 66 YATISQVAESCLIPLTVGGGVRRVKDVGDLLRAGADKVSINSAGVLSPEFIARCVDKFGS 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D + G +V G +GV + G +L T + RDG AG Sbjct: 126 QCVVVSIDCKA-SDGAWEVCTHGGARPTGVDALEYACQAAQFGAGEILLTSVDRDGVKAG 184 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTVKE 237 +++L + V + V +SGG G++ A AL G V+ L + TV + Sbjct: 185 YDLALLKAV-SSLVSVPVIASGGGGELSHFALALIEGGASAVLTASLLHRNELTVSQ 240 >UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKR3_FIBSS Length = 263 Score = 202 bits (514), Expect = 9e-51, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 107/240 (44%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ + V +G K DP+ Y+ +G + L D+T + + Sbjct: 6 LIVCLDVRNRKV---TKGVKFKGNIDIGDPVEMGARYSDEGVDELVFYDITASAENRPCD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + V +P VGGG+R+ +D+ L AG +V V S AV +++ + FG Sbjct: 63 MEMIRQIAKRVFIPFAVGGGIRNLDDMHEALLAGAEKVSVNSLAVLHPEIIAEGAKAFGR 122 Query: 122 DALVLALDVRIDEQGN-----KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +VL +D + + +V + G ++ G+ Q + +G+ + I D Sbjct: 123 QCIVLGMDAKFVGVSDKIPSGYEVFIRGGRQAMGIDALQWAKRAEELGVGEICLNSIDTD 182 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTV 235 G G +++ + + A+ QV +SGG G + L R T +V + G +TV Sbjct: 183 GVKNGYELTITDMI-AKAVQVPVIASGGAGTPAHIVDLFRKTSADAALVASMVHFGDYTV 241 >UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=60 Tax=Staphylococcus RepID=HIS4_STAAB Length = 234 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 61/233 (26%), Positives = 112/233 (48%), Gaps = 8/233 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAA-QGAEVLHLVDLTGAKDPAKR 60 + PA+DLI T VRL +G Y + + Y+ + +H+VDL GAK R Sbjct: 4 LWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAR 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + IK+L ++VGGG+R++ + AG+ +VG+ ++ D +K F Sbjct: 64 EFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFP 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++D + + V+GW+E++ ++L V+ + L ++ T I++DG ++ Sbjct: 124 G-RIYFSVDAY-----GEDIKVNGWEEDTELNLFSFVKQLSDIPLGGIIYTHIAKDGKMS 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G N L ++ + + +SGGI D+ L V I+G+A + F Sbjct: 178 GPNFELTGQL-VKATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASF 229 >UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Dictyoglomus RepID=HIS4_DICT6 Length = 242 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 76/245 (31%), Positives = 128/245 (52%), Gaps = 14/245 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ VVR+ G K N+PL + + +GA+ LHL+DL A D Sbjct: 2 LIIPAIDIYKHKVVRMETGKKEKIVLEFNNPLDLAKYWEEKGAKALHLIDLQSAIDANDE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ +V V++PV+VGGG RS E + + GV RV+V S D + F ++ Sbjct: 62 SKSIVRDIVRSVSIPVEVGGGYRSREKIEEAISWGVWRVIVSSILGMELDYLLDLFSKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++ ++D + +V + GWQ+ + + + ++ V+ TDISRDGTL Sbjct: 121 ENKIIPSID-----WYDGKVGIKGWQDF--IEWRDIKRKIDLLKVREVIFTDISRDGTLK 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-----GVRGVIVGRALLEGKFTV 235 G N+ + + + + + GGI I+DV ++ ++G+I+GRALLEGK Sbjct: 174 GVNLENIKNFLSLHDYDVWIA-GGISSIEDVIKIKDLSENTGRIKGIIIGRALLEGKINW 232 Query: 236 KEAIA 240 +EA Sbjct: 233 EEAKK 237 >UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WSE3_VEREI Length = 229 Score = 198 bits (504), Expect = 1e-49, Method: Composition-based stats. Identities = 56/208 (26%), Positives = 100/208 (48%), Gaps = 1/208 (0%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y +QGA+ L +D+ + +I+ + VP+ VGGG+RS DV +L +G Sbjct: 17 YYSQGADELVFMDIVASLYQRNNLAGIIERAADQIYVPITVGGGIRSLHDVRTMLCSGAD 76 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 +V + + AV ++ ERFG+ +VL+++ + G + V +E++G+ + V Sbjct: 77 KVAINTAAVARPGLIAEVSERFGSQCMVLSVEAKRKSGGGWEAFVDNGREHTGLDVVAWV 136 Query: 158 ETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT 217 + +G ++ T + ++GT G +V L V A V +SGG G D+ Sbjct: 137 RQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTV-AGCVTVPIIASGGYGRPSDLQQAAEA 195 Query: 218 GVRGVIVGRALLEGKFTVKEAIACWQNA 245 G G+ + AL + T+ E A + A Sbjct: 196 GASGLAIADALHWQRATIAELKAHARAA 223 >UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase subunit n=3 Tax=Bacteria RepID=Q2LTH2_SYNAS Length = 254 Score = 198 bits (504), Expect = 1e-49, Method: Composition-based stats. Identities = 61/238 (25%), Positives = 119/238 (50%), Gaps = 7/238 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ +G VV+ + + +D G DP+ Y A+GA+ L ++D+ + K + Sbjct: 6 IMPCLDMKEGRVVKGIH--FVELKDAG-DPVENAAFYQAEGADELAMLDIAATLENRKTR 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + + A + +P+ VGGG+ + ED+ +L+AG A++ + S AVK+ +V ++FG+ Sbjct: 63 LEWVNKVSAVLTIPLTVGGGISTLEDIELVLQAGAAKISMNSAAVKNPSLVSEAAKKFGS 122 Query: 122 DALVLALDVRIDEQ--GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 + + +A+D R + Q ++ VSG T +G +L T + DGT Sbjct: 123 EKITVAIDARRNSQMPSGFELVVSGGTLPVARDAVAWARTCQELGAGVILPTSMDGDGTR 182 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA-LLEGKFTVK 236 AG ++ Y + A + +SGG G ++D G +++ + +++ Sbjct: 183 AGYDIE-YTKAIADAVDLPVVASGGAGKLEDFYEAVQKGGASILLAASVFHYRTLSIR 239 >UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picrophilus torridus RepID=Q6KZD5_PICTO Length = 249 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 59/209 (28%), Positives = 103/209 (49%), Gaps = 6/209 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II ALD+ +G VV+ + + +D G DP+ Y QGA+ + +D++ + Sbjct: 6 IIAALDVRNGRVVKGVR--FMDIKDAG-DPVENAVIYQDQGADEIVFLDISATDEKRDIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I L+K++ +N+P VGGG+RS + LL G +V + + A+++ ++K G+ Sbjct: 63 IDLVKSVSRELNIPFTVGGGIRSVKTALNLLREGCDKVFLNTYAIENPWIIKEISRETGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 LV+A+D + V + + NSG+ L + + +G +L T I DGT+ G Sbjct: 123 ANLVIAVDAMYNN--GYYVYKNAGRINSGLKLNEWLPMAEYLGAGEILLTSIDSDGTMKG 180 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 + L E A + +SGG G + Sbjct: 181 FDNRLISE-AASMIDIPVIASGGAGKPEH 208 >UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hisF n=360 Tax=Bacteria RepID=HIS6_XANOM Length = 258 Score = 197 bits (501), Expect = 4e-49, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 99/247 (40%), Gaps = 9/247 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ + + D G D + Y AQGA+ L D+ + + Sbjct: 6 IIPCLDVRNGRVVKGVK--FHDHIDMG-DIVELALRYRAQGADELVFYDIGASPEGRSVD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ + +++P V GG+ E A+L AG ++ + S A+ ++ + FG Sbjct: 63 YTWVERVARLIDIPFCVAGGIGDVETARAVLHAGADKISINSPALGRPQLISELADAFGV 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGW----QENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+ +D ++ G +V + + V +G ++ + DG Sbjct: 123 QCVVVGIDSIREDDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMDNDG 182 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVK 236 G +++ +V A V +SGG G++ A V G + G + Sbjct: 183 VRRGYDIAQLRQVRA-LCHVPLIASGGAGEMQHFADVFDQADVDGALAASVFHSGAIPIP 241 Query: 237 EAIACWQ 243 E + Sbjct: 242 ELKQFLR 248 >UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria RepID=B4SDB6_PELPB Length = 256 Score = 197 bits (501), Expect = 4e-49, Method: Composition-based stats. Identities = 57/237 (24%), Positives = 107/237 (45%), Gaps = 5/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ L +G + + P Y QG + L +D + Sbjct: 6 LIARLDIKGPN---LIKGIHLEGLRVIGSPNEYALRYYQQGVDELIYMDCVASLYDRNHL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I++ + VP+ VGGG+RS ED +L +G +V V + AV + ++ RFG+ Sbjct: 63 GDIIRSAAKDIFVPMTVGGGIRSVEDATQILRSGADKVAVNTAAVANPKLINEISRRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +VL+++ + + +V +E +G+ + V+ + +G VL T + R+GT G Sbjct: 123 QCMVLSIEAKEVGKDRWEVYTDNGRERTGLDVIAWVKKGVAMGAGEVLLTSVDREGTRKG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKE 237 + +L + V A + +SGG+G +D+ + G V + L + + E Sbjct: 183 FDTALVKAVTAEVS-IPVIASGGMGKPEDLVGVVSVGGADAVAMADILHYNRAGIGE 238 >UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E352 Length = 229 Score = 196 bits (500), Expect = 4e-49, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 111/243 (45%), Gaps = 18/243 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G V L G K +G DP+ Q++++ + LH+VDL GA Sbjct: 4 IYPAIDIYNGEAVSLENGKIEKIESFG-DPVKFAQEFSSISGK-LHIVDLNGAFTGNPAN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LIK + V +Q GGG R+ E + A G+ +++G+ ++ + +++ E+ Sbjct: 62 TNLIKNIRKNVKSFMQAGGGYRTMESIEAGYSLGIDSIIIGTASL-DKKILEEVSEKH-- 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D N + +GW + + +S + T I+ DGT Sbjct: 119 KNITISIDAY-----NGYIKYNGWADGTEISYRDFYSMVKGR-ANRFIFTAINSDGTGH- 171 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + + + F +GG+ IDD+ L G G I+G+AL G ++E + C Sbjct: 172 -----ISRIEKFWDEGYFMYAGGVNSIDDLKKLENMGFNGAIIGKALYNGNIKIEE-LKC 225 Query: 242 WQN 244 QN Sbjct: 226 LQN 228 >UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=HIS4_THENN Length = 248 Score = 196 bits (499), Expect = 6e-49, Method: Composition-based stats. Identities = 76/252 (30%), Positives = 125/252 (49%), Gaps = 17/252 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL VVR+ +G Y DP+ ++ +G ++H+VDL+ A + + Sbjct: 2 LVIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEESDE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +P+++ L + + +Q+GGG+R E LL G R +V S ++ +K + G Sbjct: 62 NLPVLEKLSSYAD-HIQIGGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKL-KEIG 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V +LD R +VA GW + + LV GL+ ++ T+I +DGTL Sbjct: 120 VNP-VFSLDTR-----EGKVAFKGWLDEKDIDPVFLVNRLKEFGLEEIVHTEIEKDGTLK 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-----RGTG-VRGVIVGRALLEGKFT 234 + SL E + V ++GGI + R G ++GVIVGRA LEG T Sbjct: 174 EHDFSLTERIALE-TGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGRAFLEGTLT 232 Query: 235 VK--EAIACWQN 244 V+ + AC +N Sbjct: 233 VEVMKRYACQEN 244 >UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase subunit HisF n=1 Tax=Campylobacterales bacterium GD 1 RepID=B6BGE0_9PROT Length = 254 Score = 196 bits (499), Expect = 6e-49, Method: Composition-based stats. Identities = 47/244 (19%), Positives = 103/244 (42%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I +D+ + +G + + +P Y G + + L+D + Sbjct: 6 VIARIDIKNE---HTIKGIHLEGLRKVGNPNEMALRYYEDGIDEIVLMDAVASLYDRNSL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + +P+ VGGG+R+ +D+ L +G +V + + A++ + ++FG+ Sbjct: 63 KDVIVKACEDIFIPITVGGGLRNLQDIQEALNSGADKVAINTQAIREPSFITTASKQFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++ ++ + + G + + +E +GV + + +G ++ T I ++GT G Sbjct: 123 QCIISSIVAKKIDDGKWEAYIENGREPTGVDVLAWAKEVQELGAGEIMLTSIDKEGTKKG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ L + V A + SSGG G D+ L + + V + L +V E Sbjct: 183 FDLELNKAV-AELVNIPVISSGGAGSTKDIVHLCESSDIDAVAIASILHYKLESVSEIKK 241 Query: 241 CWQN 244 N Sbjct: 242 TLIN 245 Score = 45.8 bits (108), Expect = 0.001, Method: Composition-based stats. Identities = 22/104 (21%), Positives = 40/104 (38%), Gaps = 1/104 (0%) Query: 28 GNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEED 87 G D L ++ GA + L + + L K + VN+PV GG S +D Sbjct: 151 GVDVLAWAKEVQELGAGEIMLTSIDKEGTKKGFDLELNKAVAELVNIPVISSGGAGSTKD 210 Query: 88 VAALLEA-GVARVVVGSTAVKSQDMVKGWFERFGADALVLALDV 130 + L E+ + V + S + V + + + + +D Sbjct: 211 IVHLCESSDIDAVAIASILHYKLESVSEIKKTLINNKIKVRIDA 254 >UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hisF n=24 Tax=cellular organisms RepID=HIS6_HALS3 Length = 273 Score = 196 bits (498), Expect = 7e-49, Method: Composition-based stats. Identities = 53/222 (23%), Positives = 94/222 (42%), Gaps = 20/222 (9%) Query: 2 IIPALDLI---DGT-VVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 +IP +D+ DG V + G ++ Y DP+ + Y GA+ +D+T + + Sbjct: 7 VIPCIDVDLDDDGEPAV--YTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASAEG 64 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 + + + + V +P+ VGGG+R +D+ L AG +V + S A+ +V + Sbjct: 65 RETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRGAK 124 Query: 118 RFGADALVLALDVRIDEQGNK-------------QVAVSGWQENSGVSLEQLVETYLPVG 164 FG+ +V+++D R + V G +E +G+ + V+ G Sbjct: 125 AFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREGTGMDAIEWVQEAQRRG 184 Query: 165 LKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIG 206 + I DGT G +V L VC +S G G Sbjct: 185 AGELFVNSIDADGTQDGYDVPLTAAVC-DAVSTPVIASSGCG 225 >UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Prochlorococcus marinus str. MIT 9313 RepID=HIS62_PROMM Length = 261 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 56/220 (25%), Positives = 94/220 (42%), Gaps = 2/220 (0%) Query: 9 IDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL 68 V + + +R G DP+ + + Y AQ A+ L LVDL G D + + + Sbjct: 19 RGPKPVLVITRQFDSKRAIG-DPVSQAKIYEAQLADELVLVDLEGTSDSWPILLDTLSNM 77 Query: 69 VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLAL 128 + P+ VGGG+ S E V LL+ G +VV+ S AV + ++ +G+ +V+++ Sbjct: 78 SESLATPLSVGGGITSFEQVQQLLDRGADKVVLNSGAVNNPQLIDLVANSYGSQCVVISI 137 Query: 129 DVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYE 188 D+R + ++ V + G + SL G +L T I DGT G ++ Sbjct: 138 DIRKESDLSRHVYIDGGSTATDWSLFSWANDCASRGAGELLITSIDNDGTGTGLDLDSIR 197 Query: 189 EVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRAL 228 ++ + +SGG G A G V G Sbjct: 198 QLRYEV-NLPLIASGGCGLAQHFVAGYEVGASAVAAGTFF 236 >UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B9F8_THEAS Length = 253 Score = 194 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 65/228 (28%), Positives = 111/228 (48%), Gaps = 5/228 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L RL +G + DP+ + AQGAE + LVD+ ++ Sbjct: 6 IIPQFLLKGS---RLVKGTSFRDHVDVGDPVSQAMIQDAQGAEEIVLVDVDATREGRLVD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI +V +P+ VGGGV + +D + L AG +V+V + AV + M++ ERFGA Sbjct: 63 TSLISRMVERCRLPIAVGGGVGNVDDASRLFVAGADKVIVNTAAVLNPSMIRPLAERFGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V++LD++ + + V +E + L+E G + T + R+GTL+G Sbjct: 123 QSVVVSLDLKRNSKRGWVPVVRSGEEEVDLDFVYLLEALEANGAGEFIVTSVDREGTLSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRAL 228 ++ + +V +V +SGG G+ + L + GV +G+ L Sbjct: 183 FDLDML-KVVREVVKVPLIASGGAGNYLHLVELFLSIDLEGVGIGKML 229 >UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E201_GEOLS Length = 282 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 52/229 (22%), Positives = 98/229 (42%), Gaps = 5/229 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +V+ R G DP+ Y GA+ L D+ + Sbjct: 6 IIPRLDIKGPNLVKGIH--LEGLRVLG-DPIAFAHYYYENGADELIYSDIVASLYQRNSI 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L+ V +P+ + GG+R+ D+ L AG +V + + A+++ D + FG+ Sbjct: 63 LDLVTETSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVRVFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A++V ++ + +++SG+ V+ +G +L T I+ +GT G Sbjct: 123 STIVVAVEVVRNDDNSLIAYTENGRQSSGIEAVSWVQRVEELGAGEILLTSINAEGTGDG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALL 229 ++ L V + + + GG G + V + VR V Sbjct: 183 YDMDLINRVVSAVS-IPVIAHGGAGKPEHVREVFATSDVRAAAVASMFH 230 >UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Methanopyrus kandleri RepID=HIS4_METKA Length = 242 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 68/236 (28%), Positives = 116/236 (49%), Gaps = 10/236 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IP++D+++G V+L +GD ++ +DP+ ++ +H+VD+ A+ Sbjct: 4 VVIPSVDVVEGKCVQLVEGDPERRTFESDDPVETAHQWSEF-FPWIHVVDVDAARGEGD- 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + V+ VQVGGG+RS E L+E G R++VG+ A +D + Sbjct: 62 NSDIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDDFSKIVDVCH 121 Query: 121 ADAL--VLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 + +ALDV N +V VSGW+E++GV+LE +E + V L T + +G Sbjct: 122 DHGIEVFVALDV----NENHEVLVSGWKEDAGVTLEDAIERFNEV-ADGYLTTAVHVEGK 176 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 G + + E+ + +GGI I DV + G GV++G AL G Sbjct: 177 EMGIDEKVVEK-STGATDLPVLYAGGIASIKDVKRAKEAGAYGVVIGTALYHGDID 231 >UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LAC8_MAGSM Length = 260 Score = 191 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 45/211 (21%), Positives = 101/211 (47%), Gaps = 2/211 (0%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L +G +V+ + + K Y DP+ + + + + L ++D++ ++ A+ Sbjct: 6 VIPTLLLKEGRLVKTVRFNQAKAT-YVGDPVNTAKIFNDKEVDELAVLDISASRRGAEPD 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ L + +P+ GGGVR+ + + L +GV +V++ + +++ + +G+ Sbjct: 65 FECVEQLASECFMPLLYGGGVRNLQQIQRLFHSGVEKVMLNTAFFSGSGLLQEAVKIYGS 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +L +++DV+ D G +V G Q +G+ + G +L + +DG G Sbjct: 125 QSLGVSIDVKKDLWGRYRVMSQGGQRKTGLDPVVAAQQAEQAGAGELLLNAMDQDGMQQG 184 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA 212 ++ L + V +R + + GG + D Sbjct: 185 YDLELVQRV-SRGVAIPVIAVGGAASVADFR 214 Score = 48.5 bits (115), Expect = 2e-04, Method: Composition-based stats. Identities = 15/91 (16%), Positives = 35/91 (38%), Gaps = 1/91 (1%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 + + + + DIS A + E++ + + GG+ ++ + Sbjct: 33 DPVNTAKIFNDKEVDELAVLDISASRRGAEPDFECVEQLASE-CFMPLLYGGGVRNLQQI 91 Query: 212 AALRGTGVRGVIVGRALLEGKFTVKEAIACW 242 L +GV V++ A G ++EA+ + Sbjct: 92 QRLFHSGVEKVMLNTAFFSGSGLLQEAVKIY 122 >UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase subunit hisF3 n=18 Tax=cellular organisms RepID=HIS63_VIBVY Length = 260 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 54/229 (23%), Positives = 105/229 (45%), Gaps = 6/229 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L + + +V+ + GK Y DPL ++ + Q A+ L L+D+ ++ + Sbjct: 11 VIPVLLMREKGLVKTVKFKEGK---YVGDPLNAVKIFNEQEADELTLLDIDASRLGHEPD 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ + + +P+ GGG+++ E +L+ GV +V + S ++ ++ ER G Sbjct: 68 YVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERVGR 127 Query: 122 DALVLALDVRIDEQGNKQ-VAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++V+ LDV+ G+K + V + V+ +G ++ I DG + Sbjct: 128 QSIVVCLDVKKRLFGSKFDCFTINGTKKQSVDTIEFVKQIQTLGAGEIVLNFIDNDGVMK 187 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRAL 228 G ++ + A +V GG G +DD+A L + + G G Sbjct: 188 GYDLDAVSKFKA-LVKVPLTVVGGAGCVDDIAKLVQQEKLVGAAAGSLF 235 >UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Prochlorococcus marinus str. NATL1A RepID=A2C1S3_PROM1 Length = 248 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 59/236 (25%), Positives = 107/236 (45%), Gaps = 6/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ + V++ R G DP +Y QG E + +D + Sbjct: 3 IIGRLDVKNNHVIKGIH--LEGLRKVG-DPQELAVEYYKQGIEEIVFMDAVASLYNRNNL 59 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ V VP+ +GGG+RS +DV+ L AG +VV+ + V D+ K +++G+ Sbjct: 60 FHIIQKACEKVFVPIALGGGLRSLDDVSKALNAGADKVVINTALVNRIDLAKEIAQKYGS 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 LV +++ + E + +V V +E + ++ G+ +L T I ++GT G Sbjct: 120 QCLVGSIEAKR-ENDSWRVYVDNGREPTKHNVVDWAIKLKEAGVGEILLTSIDQEGTSKG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVI-VGRALLEGKFTVK 236 ++ L +++ + +SGG G+ +A L I + +L K TV Sbjct: 179 FDIELIKQINESI-RCPIIASGGYGNKKHLADLLKIVEPSAIAIAGSLHYKKDTVS 233 >UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_MYXXD Length = 238 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 66/234 (28%), Positives = 112/234 (47%), Gaps = 7/234 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 + IPA+DL +G V+L G Y ++ +PL L+ + G H+VDL A Sbjct: 2 IAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSN 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + + + VGGGVR + V +L G VVVG+ A++ + RF Sbjct: 62 ADAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+A DV+ ++V GW S + +++ + P+ L +L T + ++G L+ Sbjct: 122 G-RVVVAADVK-----GREVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKEGQLS 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 G ++ L EV A + +SGG+ ++D+ AL G G ++G AL G+ Sbjct: 176 GVDLPLMREV-ASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLD 228 >UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase n=2 Tax=Rothia mucilaginosa RepID=D2NNQ2_9MICC Length = 262 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 73/254 (28%), Positives = 118/254 (46%), Gaps = 19/254 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D+ +G VR G DP+ + GA +HLVDL A Sbjct: 8 LLPAVDISEGYAVRPVGGTLSGGEQ-RLDPVEAALTWVKAGARWIHLVDLDLAF-GRGTN 65 Query: 62 IPLIKTLVAGVN-----------VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 ++ +VA V V +QV GGVR+ E + L RV V S A+ Sbjct: 66 TEVLAEVVAAVRAENARMTGSAPVRIQVSGGVRNPESLERALSLNPDRVNVTSAALADSS 125 Query: 111 MVKGWFERF-GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVL 169 ++G R+ +D L L LD R + V V+ + SG + + + G++ + Sbjct: 126 WLEGTLARYADSDLLALGLDARYTPERGW-VTVARGTDWSGPGVAEALAWLEGAGVRRYI 184 Query: 170 CTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGR 226 TD+S+DG+LAG L + V A+ +SGG+ + D+ LR G+ GV++G+ Sbjct: 185 VTDVSKDGSLAGPGAELLDVVLAQ-TDRPVVASGGVASLADLVKLRSMVPSGLEGVVLGK 243 Query: 227 ALLEGKFTVKEAIA 240 AL G F+ ++A+ Sbjct: 244 ALYVGNFSFEQALE 257 >UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3E3_9BURK Length = 251 Score = 189 bits (480), Expect = 1e-46, Method: Composition-based stats. Identities = 62/248 (25%), Positives = 115/248 (46%), Gaps = 17/248 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVD--LTGAKDPA- 58 IIP++ + DG V + GD + DPL + +A GA+ LH+V L + A Sbjct: 3 IIPSIYIQDGKCVHVSYGDKTSSSPFEIDPLDLAKKWADLGADRLHIVQLGLNASTQNAT 62 Query: 59 --KRQIPLIKTLVAGVN--VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + ++ L+ V+ +P+Q+ GG+++ + + L+ G VVVGS VK + Sbjct: 63 SLSKNNEVLSKLIEEVSHYLPLQIAGGIKTMASIESYLDMGFDFVVVGSAGVKDPHFMND 122 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 F ++L LD R + +V W + + + + G+ ++ TD+ Sbjct: 123 ACSAFNGQ-VILGLDAR-----DGKVVTDSWSKVTKFDAVTIAQRLTDEGIDSIIYTDMG 176 Query: 175 RDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDID---DVAALRGTGVRGVIVGRALLEG 231 DG + N+ A+ V + G +G + ++ L GV G+I+G++L G Sbjct: 177 PDGNMTEVNLEATLNF-AKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDGIILGKSLDLG 235 Query: 232 KFTVKEAI 239 ++++EAI Sbjct: 236 VYSLQEAI 243 >UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermotogaceae RepID=HIS4_THEP1 Length = 241 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 66/242 (27%), Positives = 118/242 (48%), Gaps = 15/242 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+DL G V R+ +G Y DP ++ +G ++H+VDL+ A + + Sbjct: 2 LVVPAIDLFRGKVARMVKGKKENTIFYEKDPAELVKKLIEEGFTLIHVVDLSKAIENSVE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 P+++ L +Q+GGG+RS + L + G R +V S ++ +K + + Sbjct: 62 NFPVLERLSEFAE-HIQIGGGIRSFDYAERLRKLGYKRQIVSSKVLEDPSFLK-FLKEID 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V +LD R +VA GW + L++ GL+ ++ T+I +DGTL Sbjct: 120 VEP-VFSLDTR-----GGKVAFKGWLAEEEIDPISLLKRLKEYGLEEIVHTEIEKDGTLQ 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG------VRGVIVGRALLEGKFT 234 + SL ++ +V ++GGI + + + ++GVIVGRA LEG T Sbjct: 174 EHDFSLTRKIAIEA-EVNVFAAGGISSENSLKTAQRVHRETNGLLKGVIVGRAFLEGILT 232 Query: 235 VK 236 V+ Sbjct: 233 VE 234 >UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01ZU7_SOLUE Length = 227 Score = 187 bits (476), Expect = 3e-46, Method: Composition-based stats. Identities = 64/237 (27%), Positives = 116/237 (48%), Gaps = 15/237 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI+P +DL+DG VV+L QG ++ G+ P L+ + G + ++DL A Sbjct: 1 MIVPCIDLMDGKVVQLIQGR--EKALEGDSPDEMLRRF--AGFPEIQVIDLDAALGKGS- 55 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L+K L + +VGGGVR+ + LL G RV+VG++A + + E Sbjct: 56 NDTLVKMLASKA--VCRVGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLD 113 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ALD + ++ V GWQE + + E+++ + P LCT + ++G + Sbjct: 114 PATTIVALDSK-----GGRIVVKGWQEATEFTAEEVLHSLEPY-CSGFLCTYVDKEGMMQ 167 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G+++ + + A ++GGI ++D+ AL + VG A+ G+ ++E Sbjct: 168 GTDLDWFARLRAATAH-EITAAGGITTLEDIKALLAMNIHTA-VGMAIYTGRLDLEE 222 >UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H029_9FIRM Length = 250 Score = 181 bits (461), Expect = 1e-44, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 111/244 (45%), Gaps = 9/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+P +D+ G VV+ + + +D DP+ + Y A GA++L D+ + + + Sbjct: 4 LIMPCMDIRHGKVVKGIK--FEGVKDVA-DPVELAKYYDATGADILVFYDIAASVEDKQI 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L K++ A ++P+ GGG+++ EDV +++ G V + + A+ + D++ E+ G Sbjct: 61 YEGLFKSVRAVSDLPLVAGGGLKTIEDVDNIIKLGADMVSINTGAIDNPDLLNEAAEKIG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ ++L++D + G V + ++G+ + + G ++ I DG A Sbjct: 121 SENVILSVDAKKV-NGEYHVFRNAGMMDTGLDALEWISEGYDRGAGILVLNSIDTDGVKA 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKF---TVK 236 G ++ + + +SGG G + D AL V + + +K Sbjct: 180 GYDIEMLKA-AGEVTDAKIVASGGAGKMQDFKEALMLPKVEVALAASVFHYKEIVIDDLK 238 Query: 237 EAIA 240 E + Sbjct: 239 EYLR 242 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 58/243 (23%), Positives = 117/243 (48%), Gaps = 20/243 (8%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IP++DL+DG V+L QGD ++ ++ L++++ G + ++DL A Sbjct: 1 MLIPSIDLLDGKAVQLQQGDASRKIVEKDNLFELLEEFSLFG--EVAIIDLNAALGKGD- 57 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 LIK L+ + +VGGG+R+ E L +G ++++G++ + + ++ Sbjct: 58 NKALIKQLIKKFS--CRVGGGIRNYETAREYLSSGAKKIILGTSCRED------FVKKLP 109 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 L+ A+D + D+ GWQ +S + +++ L T + ++G + Sbjct: 110 RSQLIFAIDAKGDDW-----VTHGWQSSSDNKVAAMIDELQD-NCSEFLYTQVEKEGMMQ 163 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA-I 239 G + E+V + ++ +GGI D+DD+ + G + G ++ GK + EA + Sbjct: 164 GIDRERIEQVI-KQSKIQVTVAGGITDLDDIKFINKLGANSQL-GMSIYTGKLKLDEAVM 221 Query: 240 ACW 242 AC Sbjct: 222 ACL 224 >UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase subunit hisF2 n=17 Tax=delta/epsilon subdivisions RepID=HIS62_CAMJJ Length = 248 Score = 181 bits (459), Expect = 3e-44, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 104/241 (43%), Gaps = 8/241 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP + L +G +V+ ++ R G+ ++ Y A+ + L ++D+ +K + Sbjct: 6 IIPCVLLKNGQLVKSI--EFKDFRTIGH-LTSTMRIYNARNVDELIILDIDASKSG-EID 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ L +P+ +GGG+++ ED+ +L G ++ + S A++ D + RFG+ Sbjct: 62 FESIEDLAKECFMPLTIGGGIKTLEDIQKILNLGADKISINSKALEDMDFISKAANRFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V ++DV+ + G V G S +L Y G +L T + +G G Sbjct: 122 QCIVCSIDVKR-KGGQFCVYDRG--NLLEKSPLELALEYEKKGAGELLLTSVDFEGRAKG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++ L + + ++ +GG+ + D G + K+T K+ Sbjct: 179 YDLELLKIFQNKL-KIPLIINGGLSNPSDGVEALNLGADALAGAYIFHFSKYTPKDVKEE 237 Query: 242 W 242 Sbjct: 238 L 238 >UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=4 Tax=Vibrio RepID=A6Y2G9_VIBCH Length = 262 Score = 179 bits (456), Expect = 6e-44, Method: Composition-based stats. Identities = 61/249 (24%), Positives = 114/249 (45%), Gaps = 12/249 (4%) Query: 2 IIPALDLIDGTVVRLHQG-----DYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 + P++D++ G + +++ Y + + + GA+ +H+VDL A Sbjct: 6 LYPSIDIVGGKALTSRSAIDITLGITEEKTYLGEVFEVAELHFQSGAKWIHIVDLDAA-S 64 Query: 57 PAKRQIPLIKTLVAGVNVPVQ--VGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 LI LV + VQ V GG+RS E + + AG +RV + S + + Sbjct: 65 GVGSNQRLIMDLVKHFSEKVQTQVCGGIRSNEILEQYILAGCSRVNISSMIFDKPKLCEK 124 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 +++G + + +ALDV++ Q ++A GW G +L ++ G + + TD+ Sbjct: 125 LLKKYG-EKIAIALDVKLVNQ-EYKLATRGWNTLQG-NLWTTLDWLDNSGCQRYVLTDVD 181 Query: 175 RDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 R G+L N SL E+V + S GG+ +DD+ L G+ G ++G+ + + Sbjct: 182 RGGSLNHPNFSLLEQVLTKTST-PIISGGGLCSLDDIDRLYQIGIEGAVLGQLIHTQQHQ 240 Query: 235 VKEAIACWQ 243 +K + Q Sbjct: 241 LKRFLQYVQ 249 >UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UE29_9RHOB Length = 261 Score = 179 bits (455), Expect = 7e-44, Method: Composition-based stats. Identities = 50/220 (22%), Positives = 98/220 (44%), Gaps = 16/220 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLT-------GA 54 +IP L L++G +VR + + G DPL + + + L +D++ G Sbjct: 6 LIPVLLLMNGQLVRSE--TFTTHQIIG-DPLHEVARFNEWKVDELIYLDISRTAGLAQGR 62 Query: 55 KDPAKRQI----PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 +D R +++ + + +P+ GG V S + V + + G +V + + A ++ D Sbjct: 63 RDAGNRAYADAMDVLEAVASHCFMPLTWGGHVTSLDQVRDIFKRGADKVAINTAAYETPD 122 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 ++ +RFGA A+V+++D R E G +V G + +G + G +L Sbjct: 123 LITQVSKRFGAQAMVVSIDARQIENG-YEVMTQGGRTATGRDPVSWAKEAEDRGAGEILL 181 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 + RDG G + +L E+V + + G+G + Sbjct: 182 QSLDRDGRGTGYDTTLIEQVSQAVT-IPVIACSGVGVYEH 220 >UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase subunit n=1 Tax=Erythrobacter litoralis HTCC2594 RepID=Q2N6D2_ERYLH Length = 264 Score = 177 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 53/212 (25%), Positives = 98/212 (46%), Gaps = 5/212 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L L + V+ HQ + Y D + Q + ++ A+ L +VD+ G + Sbjct: 6 IIPVLLLDGTSAVKTHQFKPAR---YIGDIVNAAQIFNSKMADELIVVDI-GYHQDNPSR 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ L +P+ GGG+ S ++ AAL + G+ +V + + V+ +V+ +FG+ Sbjct: 62 PEVIRHLAEECFMPLAFGGGISSVDEAAALFKDGIEKVSINTAFVEGGALVEEAARQFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V ++D R + G+ QV G G+ ++ G +L I RDG G Sbjct: 122 QSVVASIDARREADGSYQVYSRGGTRALGIDPVEMARRAEAQGAGEILIQSIDRDGMRKG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 + +L + + + GG +DD+A Sbjct: 182 YDRNLVRSI-VDATTLPVVALGGADTVDDLAQ 212 >UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Roseburia RepID=C7GBG4_9FIRM Length = 252 Score = 176 bits (446), Expect = 8e-43, Method: Composition-based stats. Identities = 47/213 (22%), Positives = 87/213 (40%), Gaps = 5/213 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L V L +G + LP ++ Y + + L L+D+ + Sbjct: 6 VIPTLLYKS---VGLVKGVGFNSWRRVDTVLPAIKVYNMREVDELILLDIEATNEKRDPD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ VP VGGG+ + + LL AG +V + S A + ++ + FG+ Sbjct: 63 YDEIRDFSRECFVPFCVGGGICHIDQIKNLLRAGADKVAINSAAYDNLSLITEGAKLFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V ++D R G ++G L+ + + G +L T + DGT+ G Sbjct: 123 QCIVASIDCRK-IDGEYHCFSHNGSVDTGWLLQDWIIKVVEAGAGEILLTSVELDGTMEG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL 214 +V + ++ V +SGG G+ + + Sbjct: 182 YDVEMI-KIATSLVNVPVIASGGAGNYEHMRKA 213 >UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BNI2_9BACT Length = 248 Score = 175 bits (445), Expect = 1e-42, Method: Composition-based stats. Identities = 48/230 (20%), Positives = 106/230 (46%), Gaps = 11/230 (4%) Query: 2 IIPALDLIDG-TVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIP + +G +V+ + R G +P+ + + ++G + L +D+ K K Sbjct: 6 IIP-ILTFNGLGLVKTKG--FKNPRMVG-NPVQTARVFNSRGVDELIFLDIYATKQSRKI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + L+K ++ +PV +GGG+++ + + LL+ G +VV+ S A+ + +K FG Sbjct: 62 NLSLVKEVIKECYMPVSIGGGIQTIDQINDLLKIGADKVVIKSKALTDKKFLKEAINFFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +++DV + N + + +SLE+ + + +L ++ DG + Sbjct: 122 SQCICISVDV-LFVNNNYLIYNDLGLK---ISLEEFITEMSLINAGELLVNSVNNDGVMN 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALL 229 G ++ L +V + + ++GG G+ + + L T + V Sbjct: 178 GFDIDLINKV-EQMTTIPVIAAGGGGEPEHYSTLFNKTKINAVASSSIFH 226 Score = 48.5 bits (115), Expect = 2e-04, Method: Composition-based stats. Identities = 29/107 (27%), Positives = 45/107 (42%), Gaps = 4/107 (3%) Query: 135 QGNKQVAVSGWQENSGV-SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCAR 193 G V G++ V + Q + G+ ++ DI N+SL +EV Sbjct: 13 NGLGLVKTKGFKNPRMVGNPVQTARVFNSRGVDELIFLDIYATKQSRKINLSLVKEVIKE 72 Query: 194 YPQVAFQSSGGIGDIDDVAALRGTGVRGVIV-GRALLEGKFTVKEAI 239 + GGI ID + L G V++ +AL + KF +KEAI Sbjct: 73 -CYMPVSIGGGIQTIDQINDLLKIGADKVVIKSKALTDKKF-LKEAI 117 >UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Picrophilus torridus RepID=Q6KZD4_PICTO Length = 222 Score = 174 bits (443), Expect = 2e-42, Method: Composition-based stats. Identities = 64/242 (26%), Positives = 107/242 (44%), Gaps = 26/242 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G V L G + + YG DP+ + + LH++DL GA + ++ Sbjct: 4 VYPAIDIYNGRAVFLENGRLERIKVYG-DPVYYALRFQEY-FDFLHVIDLNGAIENKRKN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +IK ++ V VQVGGG+R+ DV + + G ++G+ D Sbjct: 62 RDVIKNIIKEVKAKVQVGGGLRTLNDVIDVYDFGAYSAIIGTNIDIEVD----------- 110 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + L++DV D +VA GW + + + T+I DGT Sbjct: 111 KNVTLSIDVYKD-----RVANRGWLNITDNDPVSFYKMLKNR-FSRFIYTNIGSDGT--- 161 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +N + E+ + F +GG+ I+DV G G+I+GRAL E + E + C Sbjct: 162 NNSGIPEKF---WDNEYFIYAGGVSGINDVKKALKNGFSGIIIGRALYENRIDPGE-LKC 217 Query: 242 WQ 243 Q Sbjct: 218 LQ 219 >UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hisF n=2 Tax=Bacteria RepID=C9YDK8_9BURK Length = 286 Score = 173 bits (439), Expect = 6e-42, Method: Composition-based stats. Identities = 49/211 (23%), Positives = 85/211 (40%), Gaps = 6/211 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPL-PRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IP L +V+ + R G P+ P ++ Y + + L LVD+ + Sbjct: 32 VIPTLLWKHFGLVKGVG--FNSWRRVG--PVLPAIKVYNQREVDELVLVDILAHGRGEEP 87 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I VP+ VGGG+ E V LL G +V + + A ++V R G Sbjct: 88 DYESIHEFGQDCFVPLTVGGGITHIEQVQRLLRVGADKVSLNTAAYARPELVSDIARRHG 147 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V ++DVR G + +G + G +L T I DG++ Sbjct: 148 VQCVVASIDVRPRAGGGWDCFSHAGTQPTGRDVVAWARELEDRGAGEILVTSIDLDGSMR 207 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 G +++L A+ ++ +SGG G+ + Sbjct: 208 GYDLALVAA-VAQAVKIPVIASGGAGNYQHM 237 >UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermoproteaceae RepID=HIS4_PYRAE Length = 229 Score = 172 bits (438), Expect = 7e-42, Method: Composition-based stats. Identities = 68/235 (28%), Positives = 105/235 (44%), Gaps = 13/235 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP++D+ G V+ +G G + DPL + A ++H+VDL GA+ Sbjct: 1 MIIPSIDIEGGRAVKRIRGQRGNY-IFQGDPLELAARFRK--APLVHVVDLDGAEAGGLV 57 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I +I + + ++GGG+RS E V L VVGS K+ + + E + Sbjct: 58 NISVISKIAEILEGRCELGGGLRSLEAVERALSL-CQYAVVGSLPFKNWPLFRRAAELY- 115 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGL-KHVLCTDISRDGTL 179 D L ++LD R +V V GW+E + S+ + V G V+ T + +GT Sbjct: 116 RDRLAVSLDYR-----GGEVLVGGWREKAA-SIAEAVRRLEEAGPYAAVIVTSVEVEGTG 169 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 G + + R + +GG+ D +DV G GVIVG AL G Sbjct: 170 GGVKADIDVKSLKRIAR-RVFYAGGVRDCNDVERAYALGFDGVIVGYALYAGDLK 223 >UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit HisF n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BR00_9RICK Length = 254 Score = 172 bits (436), Expect = 1e-41, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 92/215 (42%), Gaps = 5/215 (2%) Query: 16 LHQGD-YGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNV 74 L +G+ + ++ PL ++ Y ++ + + D+ +++ I ++ V+V Sbjct: 17 LVKGNKFENEKRSAGSPLTTVKIYNSRDVDEILFFDI--SRNNKIIDKDFILSITDCVSV 74 Query: 75 PVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDE 134 P+ +GGG+ + L E G +V + S K+ +++ +RFG+ A+ +++DVR + Sbjct: 75 PITIGGGIEKISQMNDLFEYGADKVAINSIIYKNPNIIDEASKRFGSQAITVSIDVRKNN 134 Query: 135 QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARY 194 Q N + + S L L+ + G ++ I+ DG + G + L ++ + Sbjct: 135 Q-NYECYYDLGKIKSDRKLNDLLVECVNRGAGEIVINCINNDGLMKGYDNELIQQ-TSSL 192 Query: 195 PQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 + +SGG G + G Sbjct: 193 ANIPIVASGGAGSYEHFYEAYKNGADAFAAASIYH 227 >UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L5A7_9DELT Length = 261 Score = 171 bits (434), Expect = 2e-41, Method: Composition-based stats. Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 5/212 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP + + G VV+ P ++ + + + L+ + D A R Sbjct: 6 LIPVVLVKQGLVVQSIGFRRYLPV---GRPKITVEFFNRWDCDEIVLLAIDREPDLA-RL 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L + VP+ VGGGVR ED LL AG +V + + A + +++ E FG Sbjct: 62 AGLTAHVSGAAFVPLTVGGGVRRIEDFQELLRAGADKVSLNTAAFRDPELITRAAEAFGN 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D R G +V V G +E +G G +L I RDG G Sbjct: 122 QEVVVSIDARRHADGRYEVFVGGGREATGADPRDFAREAERRGAGEILLNAIDRDGGKQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 ++ L V A + + GG+G I+ V Sbjct: 182 YDLELVRRV-ATAVSIPVIALGGVGRIEHVPE 212 >UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID=Q1N2Y7_9GAMM Length = 223 Score = 170 bits (433), Expect = 3e-41, Method: Composition-based stats. Identities = 51/214 (23%), Positives = 101/214 (47%), Gaps = 6/214 (2%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDV 88 D + ++ ++++ A+ + +VD+ A + + +PL+K L + +P+ +GGGV + ED Sbjct: 3 GDAITNVKVFSSRKADEMVIVDIE-ATEKKRINLPLLKRLSSHCIMPLTIGGGVTTLEDA 61 Query: 89 AALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQEN 148 L G +V+V S +++ +FG A+V +LDV V+ +G + Sbjct: 62 EDLFSVGADKVLVNSAFYNRPEILTDISSKFGRQAVVFSLDVMKKSNEYVPVSKNGSVKQ 121 Query: 149 SGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDI 208 S +L + VE + G ++ + DG + G +++L ++V + V +GG G Sbjct: 122 S-WTLRETVERAIEYGAGEIILNSVDCDGMMQGFDLNLCKQV-SDISSVPVVIAGGCGTK 179 Query: 209 DDVAALRGTGVRGVIVGRALL---EGKFTVKEAI 239 +D +G V G E T+K+ + Sbjct: 180 EDCVLAVNSGADAVAAGSIFYWVGESILTIKDYM 213 >UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YI32_METS5 Length = 228 Score = 170 bits (431), Expect = 4e-41, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 107/232 (46%), Gaps = 12/232 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P++D+ G V+ +G G G DPL ++ G +HLVDL A+ Sbjct: 3 VVPSIDISKGMAVKRVRGREGTGLVLG-DPLKIAEELRNMGYTSVHLVDLDAAEGKGD-N 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ ++ + + VGGG+R + L +G +VV+ + A D + + Sbjct: 61 VEVIERVMKDFS-EISVGGGIRDRSRLERFLSSGATKVVMSTLAFTKPDTFRRVVAGY-E 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++++D ++V + GW E S +S E+ + +G++ V+ T + +GT G Sbjct: 119 NRVLVSVDY-----CERKVLIKGWNE-SAMSFEEAISHVNSLGVRGVIFTYVCNEGTRNG 172 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + + V Q +GGIG I D+ L G IVG +L G Sbjct: 173 IDPEIGRYV--NLVQGEKGYAGGIGSIQDLQELDKMGFHFAIVGMSLYAGVL 222 >UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Sulfolobus RepID=HIS4_SULSO Length = 232 Score = 169 bits (428), Expect = 9e-41, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 105/232 (45%), Gaps = 9/232 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP++D+ G V+ +G G G +P+ +G +H+VDL A + Sbjct: 4 IIPSIDISFGKAVKRIRGVRGTGLVLG-NPIELANKLYNEGYSRIHVVDLDAA-EGVGNN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + +QVGGG+R E L+ V ++ + + ++ G Sbjct: 62 EMYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGN 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++++D K+V +SGW+E S + + ++ + L ++ T ++ +GT+ G Sbjct: 122 NRVIVSIDY----DDTKRVLISGWKERS-MEIIDGIKKVNELELLGIILTYVTNEGTVKG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + S+ + A+ + + +GG+ D+ L+ G +IVG A K Sbjct: 177 IDYSV--KDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKI 226 >UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZ82_ACIFD Length = 246 Score = 169 bits (428), Expect = 9e-41, Method: Composition-based stats. Identities = 85/248 (34%), Positives = 127/248 (51%), Gaps = 17/248 (6%) Query: 5 ALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR-QIP 63 A+DL+DG VRL QG + R +G DP ++ GA H+VDL A+ P R Sbjct: 6 AVDLLDGEAVRLRQGRFDAPRRFG-DPRRYVEGALDAGARWFHVVDLDRARTPGDRRNAD 64 Query: 64 LIK---TLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ LV V+VGGGVR+ D+A LLE G +RVV+G+ +V+ + Sbjct: 65 MVGDLIALVREAGGSVEVGGGVRTARDIAELLETGASRVVLGTA------LVEETLDELD 118 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + LV ALD R ++G +V VS W+ + G L + G++ L TD+ RDG + Sbjct: 119 PEHLVAALDYRRGDEGALEVVVSAWERSGGRRLLEASARLFARGVRTQLLTDVGRDGMAS 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-----VRGVIVGRALLEGKFTV 235 G ++ Y+ +C P V +SGG+ DD+A L V G +VG ALL+G Sbjct: 179 GPDLGTYQGLCEVVP-VEVIASGGVASADDLAKLAAIRGARGAVWGAVVGTALLDGSLGF 237 Query: 236 KEAIACWQ 243 EA++ + Sbjct: 238 DEALSACR 245 >UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Acidobacteria RepID=Q1IKB1_ACIBL Length = 228 Score = 169 bits (428), Expect = 1e-40, Method: Composition-based stats. Identities = 73/240 (30%), Positives = 116/240 (48%), Gaps = 19/240 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IP++DL+ G +V+L QG K+ D + + G ++ L+DL AK Sbjct: 1 MLIPSIDLMGGKIVQLVQG--EKKAFETTDFDAWCERF--AGFPMVQLIDLDAAKRQGD- 55 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVK----SQDMVKGWF 116 LI +V + +P QVGGGVR + LL G RV+VGS+ ++ D +G Sbjct: 56 NRELIANIV--LRLPCQVGGGVRDADVAERLLAIGAKRVIVGSSYIRDGRVDVDFARGLA 113 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 ER G D ++ A+D R VAV GWQE+ ++ +++ P + L T + + Sbjct: 114 ERCGTDRVIAAIDSR-----EGFVAVRGWQESVPITAGEMIAALTPY-VGGFLYTHVDTE 167 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G L G + + + ++GGI +++ L G GV +VG A+ GK VK Sbjct: 168 GLLVGFPTDIARRLRT-LTEKQLIAAGGIRSQEEIDELDGIGVD-AVVGMAIYTGKLVVK 225 >UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M908_CALMQ Length = 228 Score = 165 bits (420), Expect = 8e-40, Method: Composition-based stats. Identities = 70/234 (29%), Positives = 115/234 (49%), Gaps = 22/234 (9%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRD--YGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 ++IP++DL +G VV+ +G G + N+ L ++DY +H+VDL GA+ Sbjct: 4 LVIPSIDLSNGLVVKRVRGVKGSELVKLNLNEALSLVKDY-----PFIHVVDLNGAELGK 58 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + I + A VN +VGGGVR ED LL+ +RVV+G+ AV++ ++ R Sbjct: 59 PINVDSIAKIGATVNGRCEVGGGVRVIEDAELLLKY-CSRVVLGTVAVENPALLLNMINR 117 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVG-LKHVLCTDISRDG 177 G D + ++LD + + GW GV ++++ + + V+ T++S +G Sbjct: 118 LGVDKVAVSLDT-----DGEWLMTRGW----GVRARRIMDALSNLPRVSAVIYTNVSVEG 168 Query: 178 TLAGS--NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 T G N L + + R +GG+ DV L G G GVI+G AL Sbjct: 169 TGMGPRVNGELVKRL--RDIGKEVYYAGGVSSCSDVEYLWGLGFDGVIIGYALY 220 >UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6XVQ0_PEDHD Length = 288 Score = 164 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 98/253 (38%), Gaps = 20/253 (7%) Query: 8 LIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKT 67 + DG VV+ + K G P ++ G + + L D++ + + +I+ Sbjct: 12 VKDGIVVQSIG--FKKYLPVGK-PEIAIEFLNQWGIDEIILTDISATRKQSGPDFDMIRR 68 Query: 68 LVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLA 127 VP+ VGGG+ + + LL G ++ + + A+ + +++ FG +V++ Sbjct: 69 AAQKCFVPLTVGGGISNTGQMKELLHNGADKISLNNAAITTPELITETAHIFGGQCVVIS 128 Query: 128 LDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLY 187 +D I ++ +S + + G +L + RDG+ G + L Sbjct: 129 ID-GIHTNKGFRIYDYLTHSALDISPSEFAKRAEDSGAGEILINSVDRDGSYLGFDHELI 187 Query: 188 EEVCARYPQVAFQSSGGIGDIDDVAAL--------------RGTGVRGVIVGRALLEGKF 233 VC+ + GG + D + V + +++L K Sbjct: 188 NSVCS-VVNIPVIVCGGAKNAGDFIEVFSKTNASAATAANFFHFSEHSVNITKSILNKKM 246 Query: 234 TVK-EAIACWQNA 245 V+ EA A +++A Sbjct: 247 DVRSEAFANYEDA 259 >UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SPR8_NEMVE Length = 545 Score = 163 bits (414), Expect = 4e-39, Method: Composition-based stats. Identities = 59/291 (20%), Positives = 106/291 (36%), Gaps = 66/291 (22%) Query: 15 RLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIK---TLVAG 71 + +GD DP+ + + + GA+ + +++T + + ++K Sbjct: 253 KPVKGDVKAV----GDPVELGERFFSDGADEIAFLNITSFRSSPIHDLAMLKLLRKCCER 308 Query: 72 VNVPVQVGGGVRS---------------------EEDVAALLEAGVARVVVGSTAVKSQD 110 + VP VGGG+R E A ++G +V V S AV + + Sbjct: 309 IFVPFTVGGGIRDIYALDPDSVEEGKPVMRQFSALEVAAMYFKSGADKVSVASDAVYAAE 368 Query: 111 M-------------VKGWFERFGADALVLALDVRI-----------------------DE 134 ++ ER+G A+VLA+D + ++ Sbjct: 369 EFIASGHKKTGKTSIEKIAERYGRQAVVLAVDTKTVYVPSPDSTKHHTVKARYPGPNGEK 428 Query: 135 QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARY 194 Q V G +E V +LV+ +G +L +I RDGT G ++ L + V Sbjct: 429 YVWWQCTVKGGRETRDVGAYELVKACEELGAGEILLNNIDRDGTNHGYDLDLVKMVKGAV 488 Query: 195 PQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 + +S G G + D L R T G + G G+ + + +N Sbjct: 489 S-IPVIASSGAGHVSDFVDLFRETNADGAMAGAIFHRGEVDITDVKEHLRN 538 >UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. AS9601 RepID=A2BSD9_PROMS Length = 254 Score = 160 bits (405), Expect = 5e-38, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 95/220 (43%), Gaps = 6/220 (2%) Query: 15 RLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDL-TGAKDPAKRQIPLIKTLVAGVN 73 R+ + K Y DPL ++ + ++ + + ++ K ++ + Sbjct: 17 RMIKRSKFKNYKYLGDPLNIIRIFNSKRVDEISIISCENYEKKDINIDFEFLEKISGEAF 76 Query: 74 VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRID 133 P+ GGVRS ED L G ++ + + + +++K E++G+ ++V+ +D + Sbjct: 77 CPLTYSGGVRSLEDADKLFSIGFEKIGIRNLLHTNPEVIKQIAEKYGSQSVVIFIDYKEL 136 Query: 134 EQGNKQVAV--SGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVC 191 ++ + + +++ S+ + ++ G V+ I R+G G ++ + +E+ Sbjct: 137 NNNEIEIYTSYNSFFKSTKSSILEFIKNAESYGAGEVVLQSILREGQSKGLDLDIIKEIT 196 Query: 192 ARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGR--ALL 229 + + SS G+ D+ D G GV+ + +L Sbjct: 197 NK-TILPIISSCGMRDLSDARKAFSLGADGVMASKFFSLY 235 >UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C5E2I9_LACTC Length = 550 Score = 159 bits (402), Expect = 9e-38, Method: Composition-based stats. Identities = 58/305 (19%), Positives = 114/305 (37%), Gaps = 62/305 (20%) Query: 2 IIPALDLI---DGTVVRLHQGDYG-KQRDYGND------PLPRLQDYAAQGAEVLHLVDL 51 II LD+ G +V Y +++ G + P+ Q Y QGA+ + +++ Sbjct: 238 IIACLDVRTNDQGDLVVTKGDQYDVREKQEGGNVRNLGKPVELAQKYYEQGADEVTFLNI 297 Query: 52 TGAKDPAKRQ---IPLIKTLVAGVNVPVQVGGGVRSEEDVA-----------ALLEAGVA 97 T +D + + ++K V VP+ VGGG++ DV +G Sbjct: 298 TSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTHIPALQVAALYFASGAD 357 Query: 98 RVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRIDEQGN------- 137 +V +GS AV + + ++ + +GA A+V+++D + Sbjct: 358 KVSIGSDAVYAAEKYYELGERGDGASPIETISKSYGAQAVVISVDPKRVYVDGPESVKHK 417 Query: 138 ----------------KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 Q + G +E+ + + +L +G VL I +DG+ +G Sbjct: 418 TFETKFPNEKGQTWCWYQCTIKGGRESRDMGVWELTRACEALGAGEVLLNCIDKDGSNSG 477 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ L ++ +S G G+ A TG + G++TV + Sbjct: 478 YDLELINH-AKEAVKIPVIASSGAGEPKHFKEAFESTGADACLGAGMFHRGEYTVNDVKQ 536 Query: 241 CWQNA 245 ++ Sbjct: 537 YLLDS 541 >UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Vibrio vulnificus YJ016 RepID=HIS62_VIBVY Length = 272 Score = 158 bits (401), Expect = 1e-37, Method: Composition-based stats. Identities = 47/225 (20%), Positives = 92/225 (40%), Gaps = 14/225 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRL-QDYAAQGAEVLHLVDLTGAKDPAKR 60 +IP + + G +V + + GN + + + + + D+ +K+ + Sbjct: 9 LIPCI-VTKGELV-VQSFAFKNYLPIGN--VKTAIDFFVNWDVDEIIVNDIDASKEFREP 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + L+ VP+ VGGG+++ E + LL+AG +V + + A+ D +K FG Sbjct: 65 NVDLVSWAAKECFVPLTVGGGIKTLEHIRNLLKAGADKVTINTKAIDDPDFIKNAASVFG 124 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +++D I + ++ V + V G +L + RDG+ Sbjct: 125 SQCITVSVDA-IKQGNVYKLYDYRDGRVLDVDVVDWVRKVESYGAGEILLNSVDRDGSRE 183 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVG 225 G +V L + V + + GGIG D + G I G Sbjct: 184 GYDVELLKTVSG-IVSIPVIALGGIGRFDQL-------AEGAIEG 220 >UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Sulfolobus acidocaldarius RepID=Q4J8J0_SULAC Length = 226 Score = 157 bits (397), Expect = 4e-37, Method: Composition-based stats. Identities = 60/232 (25%), Positives = 107/232 (46%), Gaps = 14/232 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P++D+ + V+ +G G G DPL ++ ++G + +H+VDL A+ Sbjct: 3 VMPSIDISNKVAVKRIRGKGGSGIILG-DPLKIAKEIISEGYDAIHIVDLDAAEGLGD-N 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +IK + QVGGGVR E +LE + +VV + + ++ G Sbjct: 61 KDIIKQICTLGFSWTQVGGGVRKLEIAKDILEY-CSSIVVSTLPITNRQEYDKIISGVGV 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + L++D N V + GW+E S V + L+ + V+ T I +GT G Sbjct: 120 DKVFLSIDY----DDNGYVLIKGWKEKS-VKVSDLL----DLESGGVIFTYIPNEGTKGG 170 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + ++ E V + + + +GGIG +DD+ L+ G I+G + G Sbjct: 171 IDNNVVEYV--KSVKKIKEYAGGIGSLDDLLKLKSFGFDYSIIGMSFYNGTL 220 >UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_YEAST Length = 552 Score = 157 bits (397), Expect = 4e-37, Method: Composition-based stats. Identities = 59/301 (19%), Positives = 116/301 (38%), Gaps = 64/301 (21%) Query: 2 IIPALDLI---DGTVVRLHQGDYGKQRDYGN--------DPLPRLQDYAAQGAEVLHLVD 50 II LD+ G +V + +GD R+ + P+ Q Y QGA+ + ++ Sbjct: 240 IIACLDVRTNDQGDLV-VTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVTFLN 298 Query: 51 LTGAKDPAKRQ---IPLIKTLVAGVNVPVQVGGGVRSEEDVA-----------ALLEAGV 96 +T +D + + ++K V VP+ VGGG++ DV +G Sbjct: 299 ITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGA 358 Query: 97 ARVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRI----------- 132 +V +G+ AV + + ++ + +GA A+V+++D + Sbjct: 359 DKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKN 418 Query: 133 ------------DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ Q + G +E+ + + +L +G +L I +DG+ + Sbjct: 419 KVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDGSNS 478 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTVKEAI 239 G ++ L E V ++ +S G G + A T + G+FTV + Sbjct: 479 GYDLELIEHV-KDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVNDVK 537 Query: 240 A 240 Sbjct: 538 E 538 >UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41F9C Length = 231 Score = 156 bits (395), Expect = 6e-37, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 108/241 (44%), Gaps = 21/241 (8%) Query: 2 IIPALDLIDGTVVRLHQGDYGK----QRDY--GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL++ V G+ Q Y +DPL + GA+ +++ DL + Sbjct: 4 IIPVIDLMNSVAVSGKSGNRETYTPLQTIYASSSDPLEIALSLKSAGAKEMYIADLDFIE 63 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 I IK + + +PV + GV E LLE +++V + ++S + + Sbjct: 64 RNGNNNIFKIKEVNSV--LPVILDVGVDKLETFEFLLEF-AYKIIVATETLESIEELGKI 120 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 FE++ + +++++DV+ +E + +N + LE E + ++ DIS Sbjct: 121 FEKYPKERIIVSVDVKNNEL---------YAKNMDLDLEGFKEVLRRIDPNEIILLDISS 171 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 GT G N L E ++ GGI D+++ L G+R +VG AL +G+ + Sbjct: 172 VGTEGGFNKPLLESFEEFKDKI--ILGGGI-TPDEISQLDALGIRKALVGTALHKGQIRL 228 Query: 236 K 236 Sbjct: 229 N 229 >UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) n=8 Tax=Saccharomycetales RepID=C4R8P0_PICPG Length = 561 Score = 155 bits (393), Expect = 1e-36, Method: Composition-based stats. Identities = 54/298 (18%), Positives = 109/298 (36%), Gaps = 62/298 (20%) Query: 2 IIPALDLI---DGTVVRLHQGDYG-KQRDYGND------PLPRLQDYAAQGAEVLHLVDL 51 II LD+ G +V Y +++ D P+ + Y QGA+ + +++ Sbjct: 250 IIACLDVRTNDSGDLVVTKGDQYDVREKSESGDVRNLGKPVEMAEKYYQQGADEVTFLNI 309 Query: 52 TGAKDPAKRQ---IPLIKTLVAGVNVPVQVGGGVRSEED-----------VAALLEAGVA 97 T ++ + + ++K V VP+ VGGG++ D AG Sbjct: 310 TSFRNSPIKDAPMLEVLKRAAETVFVPLTVGGGIKDVVDPDGTKVPALKVATLYFRAGAD 369 Query: 98 RVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRIDEQGN------- 137 +V +G+ AV + + ++ +G A+V+++D + + Sbjct: 370 KVSIGTDAVLAAEEFYRNNEKGTGLTPIETISASYGVQAVVISVDPKRFYVADPSKTPYK 429 Query: 138 ----------------KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V G + + +L +G +LC I +DG+ +G Sbjct: 430 TIKTKFPGPNGENYCYYKVTSQGGRNVHDLGAWELCYACEKLGAGEILCNCIDKDGSNSG 489 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKEA 238 ++ L + + ++ +S G G+ R T + G++TVKE Sbjct: 490 YDLELIDYI-KSATKLPVIASSGAGNPSHFEEVFRKTETDAALGAGMFHRGEYTVKEV 546 >UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEW9_METST Length = 239 Score = 154 bits (389), Expect = 3e-36, Method: Composition-based stats. Identities = 52/248 (20%), Positives = 108/248 (43%), Gaps = 18/248 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQR----DYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 MIIP +D++ V G + YG++PL GA+++++ DL + Sbjct: 4 MIIPVIDIMHNECVSGKSGRRSTYKKLRSIYGDNPLDIATALKEDGAQLIYIADLDKIER 63 Query: 57 PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 +PV + G+ S ED+ + + ++ + + S D ++ F Sbjct: 64 IDDNNN---IISSINNIIPVMLDNGISSIEDIENN-KNICSYNILATETMTSLDNIEEIF 119 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +++ ++ LV+++D++ N ++ V+ N + LE ++ K+ + +IS Sbjct: 120 KKYDSNKLVVSIDIK-----NNELLVN----NKDIDLEDVIYLINKYKPKYTIILNISYV 170 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 GT G N ++ EE+ + P +GGI + D+ + ++G L EG + K Sbjct: 171 GTKKGVNTNIIEEITKKIPHTKCCIAGGIRN-SDIETYTKKNINNFLIGTLLHEGNLSYK 229 Query: 237 EAIACWQN 244 + +N Sbjct: 230 LYMESKKN 237 >UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=uncultured marine bacterium 440 RepID=Q6SHC0_9BACT Length = 262 Score = 154 bits (389), Expect = 3e-36, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 103/236 (43%), Gaps = 17/236 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAK------ 55 IIP L + +G +VR ++ K + G + + + + + L +D+T Sbjct: 7 IIPVLFIKNGLIVR--SQNFYKHQFIG-NVIEQAKRLNDYDVDELVYIDITRNDNYDLGR 63 Query: 56 -----DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 + + +IK + +P+ GGG+RS +D + AG ++ + S K + Sbjct: 64 DDLLVKSKRDIMSIIKDISKVCFMPLTFGGGIRSVDDAVNRIRAGADKITINSLLYKDLN 123 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 +VK G+ A+V ++D +I + + + Q+N+ + L ++ +G+ Sbjct: 124 IVKKIISEIGSQAVVASIDYKIINE-KLIIFNNFGQDNTNIELIDFIKKIENLGVGEFFI 182 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD-VAALRGTGVRGVIVG 225 ++ DG G +++ +++ + + G G ++ + A++ G+ V G Sbjct: 183 QNVELDGMQKGFDLNNIKKI-VNSVNLPVIACSGAGSLEHFLEAVKIKGLSAVAAG 237 >UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V5Z6_9AQUI Length = 119 Score = 152 bits (385), Expect = 1e-35, Method: Composition-based stats. Identities = 43/114 (37%), Positives = 75/114 (65%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ +G VRL++GD + YG++P+ + + +GA+ LH+VDL GA + + Sbjct: 6 FIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHIVDLDGAFEGIPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 +++ +V VNVP++ GGG+R+ E V ++E GV RVV+GS A + +++ + Sbjct: 66 NYKIVEQIVKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDKELFEK 119 Score = 47.0 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 45/114 (39%), Gaps = 5/114 (4%) Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++ A+D++ + G + ++ + + G KH+ + DG Sbjct: 4 KEFIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHI--VDLDGAFE 61 Query: 181 GS--NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 G N + E++ + V + GG+ + V + GV V++G + K Sbjct: 62 GIPKNYKIVEQI-VKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDK 114 >UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes: glutamine amidotransferase; cyclase], putative n=6 Tax=cellular organisms RepID=B9WJS1_CANDC Length = 622 Score = 149 bits (378), Expect = 6e-35, Method: Composition-based stats. Identities = 56/318 (17%), Positives = 112/318 (35%), Gaps = 78/318 (24%) Query: 2 IIPALDLI---DGTVVRLHQGDYGKQR----------------DYGNDPLPRLQDYAAQG 42 II LD+ DG +V + +GD R P+ Y QG Sbjct: 292 IIACLDVRTNDDGDLV-VTKGDQYNVREQQSSSSKISENSNQVRNLGKPVELATKYYNQG 350 Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTL---VAGVNVPVQVGGGVRSE------------ED 87 A+ + +++T ++ + +P+++ L + VP+ VGGG++ + Sbjct: 351 ADEITFLNITSFRNSPLKDLPMLQVLRKSAETIFVPLTVGGGIKDLYDSETKKIIPAVDI 410 Query: 88 VAALLEAGVARVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRIDE 134 ++G ++ +GS AV + ++ +FG A+V+++D + Sbjct: 411 AHLYFQSGADKISIGSDAVIIAENYYANNQIPLGTSSIETISSKFGNQAVVISVDPKRKY 470 Query: 135 QGN---------------------------KQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 N QV G ++ + +L +G Sbjct: 471 IKNPQLDTTMETIKIIDPLQYGPNGEQYCYYQVTSQGGRKLHELGALELCLACEKLGAGE 530 Query: 168 VLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT--GVRGVIVG 225 +L I DG+ G N+ L +++ + + +S G G+ + G+ + Sbjct: 531 ILLNSIDNDGSNKGFNLQLLQQI-KSHVSIPVIASSGAGNPQHFQQVFEMDCGIDAALGA 589 Query: 226 RALLEGKFTVKEAIACWQ 243 G++TV E Q Sbjct: 590 GIFHRGEYTVNEVKKYLQ 607 >UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. BL107 RepID=Q062W6_9SYNE Length = 255 Score = 149 bits (378), Expect = 7e-35, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 83/181 (45%), Gaps = 3/181 (1%) Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVG 102 + L ++D++ K + ++ + +P+ +GG + S +D L+ G ++++ Sbjct: 47 IDELVILDVSREKPDRQEFCEVVNEVCQNCFMPLALGGHINSLDDAKMLIYNGADKLIIN 106 Query: 103 STAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP 162 + ++ ++V+ +G+ ++ ++D +I E+G+ V + ++ L + +E Sbjct: 107 TALHENPNLVRELIAIYGSQCIIGSVDYKI-EEGSFIVYTNQGKKRLDRPLNEHIERLGE 165 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRG 221 +G+ + I RDGT G + +++ + +GG G+ + L GV Sbjct: 166 MGVGELYLNSIDRDGTGQGYVSEVLKQL-DSASHLPIIQAGGAGNKHHLQESLECRGVDA 224 Query: 222 V 222 V Sbjct: 225 V 225 >UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TG14_METVO Length = 148 Score = 149 bits (377), Expect = 7e-35, Method: Composition-based stats. Identities = 44/134 (32%), Positives = 82/134 (61%), Gaps = 5/134 (3%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDV 88 ++P + + GAE+LHLVDL GA D + +P++K ++ VPVQ+GGG+R+ EDV Sbjct: 4 DNPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIEDV 63 Query: 89 AALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQEN 148 L+ G+ RV++G+ AV++ D V+ ++ G++ +++ALD + + +V + GW+E Sbjct: 64 EELVNLGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVALDAK-----DGKVVIKGWKEK 118 Query: 149 SGVSLEQLVETYLP 162 + + Q+ + Sbjct: 119 TEYTPVQMGKYLRK 132 Score = 48.1 bits (114), Expect = 3e-04, Method: Composition-based stats. Identities = 18/77 (23%), Positives = 38/77 (49%), Gaps = 5/77 (6%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAG--SNVSLYEEVCARYPQVAFQSSGGIGDID 209 + +++ + ++ G + + + DG + G N+ + +++ +V Q GGI I+ Sbjct: 5 NPDEIAKMWVENGAEMLHL--VDLDGAIDGERVNLPMVKKIIQE-SKVPVQMGGGIRTIE 61 Query: 210 DVAALRGTGVRGVIVGR 226 DV L G+ VI+G Sbjct: 62 DVEELVNLGINRVIIGT 78 >UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepID=Q4JIN2_9BACT Length = 248 Score = 147 bits (373), Expect = 2e-34, Method: Composition-based stats. Identities = 61/242 (25%), Positives = 104/242 (42%), Gaps = 18/242 (7%) Query: 2 IIPALDLIDGTVVRLHQG---DYGKQRDYG------NDPLPRLQDYAA-QGAEVLHLVDL 51 +I +DL G V G DY R G DP + Y +G L++ DL Sbjct: 3 VIGVIDLAAGRAVHARGGRRTDYAPVRLSGAAAAHVGDPCALARTYLETRGLTELYVADL 62 Query: 52 TGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM 111 A Q I L+ + P+ + GV S L G + VVVG + S D+ Sbjct: 63 D-AIGGGPSQDAAIGALIR-LGAPLWLDSGVHSVPRARHALGLGASFVVVGLETLPSYDV 120 Query: 112 VKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 + G++ + +LD+R + + +G S+EQ+ + G+ ++ Sbjct: 121 LSEICADVGSERVAFSLDLR-----DGLPITAHADVAAGRSVEQIAARAVEAGVGAIIVI 175 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 D++R G G +++L + + P V + GG+ +D+A+L G GV+V AL +G Sbjct: 176 DVARVGMGEGVDLALISSLRSVAPAV-LLAGGGVRGSEDLASLAHAGCDGVLVATALHDG 234 Query: 232 KF 233 + Sbjct: 235 RI 236 >UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=1 Tax=Cyanothece sp. PCC 7425 RepID=B8HVG9_CYAP4 Length = 226 Score = 147 bits (372), Expect = 3e-34, Method: Composition-based stats. Identities = 66/228 (28%), Positives = 99/228 (43%), Gaps = 17/228 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPAL +++G Q + DP+ + +A QGA LHL+D G A Sbjct: 3 IIPALKIMEGFCCHHRQ-----PYRFNCDPVAMAEQWANQGATRLHLIDCNGVTTGAMLN 57 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P I +V V VPVQV G + S + L GV RVVV + + ++V E F Sbjct: 58 LPTIAAIVQQVKVPVQVEGTIYSRAQIETLFAIGVDRVVVDGS-IGWSELVADLCEHFSG 116 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V E + +VA SG E +G+ L E VG ++ TDI+R G+ Sbjct: 117 KIMV------NLEAYDGRVACSG--ELTGLLATTLAERAEAVGAAGIIYTDIARQGSGI- 167 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 N+ + + R + + GG I ++ L IVG + Sbjct: 168 INLKALKHLADRV-NLPIIAGGGASSIAELLRLFNPSTP-QIVGMMVY 213 >UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms RepID=C1FJN8_9CHLO Length = 601 Score = 145 bits (366), Expect = 1e-33, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 108/298 (36%), Gaps = 62/298 (20%) Query: 2 IIPALDLID---GTVVRLHQGDYG-KQRDYGND------PLPRLQDYAAQGAEVLHLVDL 51 +I LD+ G +V Y +++D GND P+ Y QGA+ + +++ Sbjct: 287 VIACLDVRSNDAGDLVVTKGDSYDVREKDDGNDVRNLGKPVELAGKYFKQGADEVAFLNI 346 Query: 52 TGAKDPAKRQIPLIKTLVAG---VNVPVQVGGGVRS-----------EEDVAALLEAGVA 97 TG +D P+++ L V VP+ VGGG+R E AA +AG Sbjct: 347 TGYRDLPLTDAPMLEVLRRSSETVFVPLTVGGGIRDFTDSNGVSYTALEVAAAYFKAGAD 406 Query: 98 RVVVGSTAVKSQDM-------------VKGWFERFGADALVLALD--------------- 129 +V +GS AV + ++ ER+G A+V+++D Sbjct: 407 KVSIGSDAVYVAEQYYANDKKKDGCTSIEQISERYGVQAMVVSIDPRRAYVADPSETKNR 466 Query: 130 ----VRIDEQGNKQV----AVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 R G + V V G +E + +L +G +L I DG G Sbjct: 467 CIKTSRPGPNGEEYVWFQCTVKGGREGRDIGAYELAIAMEDLGCGEILLNCIDEDGQGNG 526 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKEA 238 + L + A + +S G G+ T + G+ + E Sbjct: 527 FDHELVG-LVADAVTIPVIASSGAGEPKHFTDVFNATKCSAALAAGIFHRGEVDISEV 583 >UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n=3 Tax=Basidiomycota RepID=Q5KNA0_CRYNE Length = 619 Score = 144 bits (364), Expect = 2e-33, Method: Composition-based stats. Identities = 56/317 (17%), Positives = 109/317 (34%), Gaps = 82/317 (25%) Query: 2 IIPALDLID---GTVVRLHQGDYGKQRDYGND--------PLPRLQDYAAQGAEVLHLVD 50 I+ LD+ G +V + +GD R+ +D P+ Q Y GA+ + ++ Sbjct: 286 IVACLDVRSNDAGDLV-VTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVAFLN 344 Query: 51 LTGAKDPA---KRQIPLIKTLVAGVNVPVQVGGGVRS-----------EEDVAALLEAGV 96 +T + A + + +++ V VP+ +GGG++ E A +G Sbjct: 345 ITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFRSGA 404 Query: 97 ARVVVGSTAV------------KSQDM-----VKGWFERFGADALVLALDVRIDEQG--- 136 +V +GS AV + ++ + +G A+V+++D + Sbjct: 405 DKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVDTSA 464 Query: 137 ----------------------------------NKQVAVSGWQENSGVSLEQLVETYLP 162 Q +SG + + + QL + Sbjct: 465 PGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQCTISGGRAVRDIDVVQLAQGVER 524 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRG 221 +G +L + RDG+ G ++ L ++ + SS G G D R TG Sbjct: 525 LGAGEILLNSVDRDGSGQGFDLDLV-KLVKNAVGIPVVSSSGAGSPADFEEVFRETGTEA 583 Query: 222 VIVGRALLEGKFTVKEA 238 + G+ + E Sbjct: 584 ALAAGIFHRGEVGIDEV 600 >UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NHA2_KYTSD Length = 470 Score = 143 bits (362), Expect = 4e-33, Method: Composition-based stats. Identities = 67/246 (27%), Positives = 103/246 (41%), Gaps = 27/246 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ G R Q D +DP + + AQGAE LHLVDL A A Sbjct: 5 LWPAVDVRGG---RTAQVDPDSPL---SDPQAAVDHWVAQGAERLHLVDLDRA-TGAGEN 57 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ LV +VPV+V GG+ S DV L G V S W + GA Sbjct: 58 DALLERLVRRASVPVEVSGGILSPRDVERALSWGAVAVTTSSALWADPAAALEWLQGCGA 117 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP---VGLKHVLCTDISRDGT 178 + + V ID G++ VA + ++L + + + +G + + + DG Sbjct: 118 E-----VQVGIDLVGDRVVA-----RGTDLALGPVADLWPDLAGLGERRWVLASAAADGR 167 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRG-----VIVGRALLEGK 232 + G +++ +SGG+ D+ A+ GV G VI+G AL G Sbjct: 168 MTGPDLAGLRAATEHLTGT-LIASGGVSTTGDLVAVSSLRGVAGPAVGEVILGAALYAGA 226 Query: 233 FTVKEA 238 + A Sbjct: 227 VDLGRA 232 >UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Synechococcus sp. WH 8102 RepID=HIS62_SYNPX Length = 269 Score = 143 bits (361), Expect = 6e-33, Method: Composition-based stats. Identities = 38/176 (21%), Positives = 79/176 (44%), Gaps = 2/176 (1%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y+A + L ++D++ + L+ L + VP+ GGG+RS ED L E G Sbjct: 42 YSATFIDELIILDISRKSRDINKFATLLYNLSENIFVPITAGGGIRSFEDAKVLFENGAD 101 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 +V + ++ ++ + + +G +LV ++D + D G+ + + ++++L+ Sbjct: 102 KVCLNTSLIQCPHVSEKISSVYGQQSLVASIDFKHDH-GDFKFFIDNGLIEVQYNIQELI 160 Query: 158 ETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 P+ +L + RDGT G +++L + + GG G D + Sbjct: 161 SFLDPLPFCEILLQSVDRDGTGTGFDLTLANTFRDQLSK-PIILLGGAGHSDHLVE 215 >UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methanobrevibacter smithii RepID=A5UNR3_METS3 Length = 229 Score = 140 bits (355), Expect = 3e-32, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 102/239 (42%), Gaps = 22/239 (9%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 +P LDL D V G +P+ + GA+ L++ DL + Sbjct: 5 VPVLDLKDNIAVSGKSGLRDTYTPLQTVFAPSANPVDIANGLSINGADELYIADLDLIEG 64 Query: 57 PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 + +V + +PV + GV+ E L+ +++V + +KS +K F Sbjct: 65 NGHNIHDV--KMVNSI-LPVMLDAGVKDFESFTFFLDY-AYKIIVPTETIKSIGEIKKIF 120 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 E++ + +V+++DV+ +E + +N +SL + E + ++ DI+ Sbjct: 121 EKYPKERIVVSVDVKDNEL---------YSKNLNISLAEFKEILEELDPDEIILLDITGV 171 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 GT G N L ++ + +GG+ + V+ L G++ V+VG AL G+ + Sbjct: 172 GTQKGYNQELLDDFKDLKDK--LIIAGGLNNKS-VSELEDMGIKKVLVGTALHSGEMKL 227 >UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=O26765_METTH Length = 227 Score = 139 bits (352), Expect = 7e-32, Method: Composition-based stats. Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 23/236 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQR----DYGN--DPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL+DG V G+ K R Y DP+ A GA +++ DL A Sbjct: 4 IIPVIDLMDGIAVSGKSGEREKYRPLESVYSPSPDPVNIALSLRAAGARSIYIADLD-AI 62 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 + + ++ + +PV + GVR E +LE +RVVV + ++S + ++ Sbjct: 63 EGTGSNLEAVRRVNHV--LPVILDAGVRDLETFHFMLEF-ASRVVVATETLESTEELEEI 119 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 + + V+++DV+ + N + LE+L + + + ++ DI Sbjct: 120 LRNYPPERTVVSVDVKD---------MRLHSRNLEIGLEELRDLLMGYEVD-IILLDIGS 169 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 GT +G N L E P + GG +++ L GVR +VGRAL EG Sbjct: 170 VGTSSGFNRELLELFR---PLIERVIPGGGVLPEEIPELEAMGVRAALVGRALHEG 222 >UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase HisF n=1 Tax=Sphingobacterium spiritivorum ATCC 33300 RepID=C2G0W0_9SPHI Length = 263 Score = 139 bits (352), Expect = 7e-32, Method: Composition-based stats. Identities = 39/180 (21%), Positives = 82/180 (45%), Gaps = 3/180 (1%) Query: 44 EVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGS 103 + L +++++ + + LV G +PV VGGG+RS ED L ++G ++V+ + Sbjct: 48 DELVILNVSRKSKNQEEFGRTVSRLVEGTYMPVAVGGGIRSLEDAEMLFKSGADKIVLNT 107 Query: 104 TAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPV 163 + D+VK +++G+ ++V ++D + + ++ + N E + + Sbjct: 108 SLSSDPDLVKLIVQKYGSQSVVASIDYLKKGESS-EIFIENGSLNINEGFENYLSHLKDL 166 Query: 164 GLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGV 222 + V + RDGT G + SL ++ V +GG G+ + AL + + Sbjct: 167 NVGEVYLNSMERDGTGFGYDFSLV-KLVKSILNVPLIIAGGAGNEGHLKEALLHSEISAA 225 >UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=Lactobacillus fermentum RepID=C0WXE8_LACFE Length = 188 Score = 139 bits (351), Expect = 8e-32, Method: Composition-based stats. Identities = 39/183 (21%), Positives = 82/183 (44%), Gaps = 4/183 (2%) Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ + V +P+ V VR+ +V LL AG +V + + ++ + D + + FG Sbjct: 1 MLDMVEAISQQVFMPMTVVCNVRTVVEVRNLLLAGADKVGISTRSIMAPDFIPKVAQVFG 60 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++V LD +D + N+++ + N+ + + + +G+ +L + RDGT Sbjct: 61 NQSIVAILDYHVDPRTNRKIVCTPG--NTELDAYEWTLRVVELGVGELLVNSMDRDGTEN 118 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKEAI 239 G + + Y ++ + +SGG G D +GV G + A + T+ E Sbjct: 119 GFDTAFYRDLTTTLT-IPVVASGGAGSTVDFEEVFVNSGVTGAMAASAFHLDQMTISEVK 177 Query: 240 ACW 242 Sbjct: 178 ETL 180 >UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC778 Length = 164 Score = 139 bits (351), Expect = 9e-32, Method: Composition-based stats. Identities = 39/153 (25%), Positives = 76/153 (49%) Query: 15 RLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNV 74 + +G K + P + Y+ GA+ L D+T + + K + + + +N+ Sbjct: 8 KSCKGKKFKDIVDVDSPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENINI 67 Query: 75 PVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDE 134 P VGGGV ED +L G +V + S+AVK+ ++++ +FGA +VL++D + +E Sbjct: 68 PFCVGGGVNKLEDFTDILRKGADKVSINSSAVKNPELIREASLKFGAQCVVLSIDAKKNE 127 Query: 135 QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 +G+ V V G +E + + +G++ Sbjct: 128 EGSWSVYVKGGREKLIWMQLNGLLKVVELGVRR 160 >UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit HisF2 n=3 Tax=Rhizobium RepID=Q7WYR2_RHIL3 Length = 251 Score = 139 bits (350), Expect = 1e-31, Method: Composition-based stats. Identities = 41/210 (19%), Positives = 86/210 (40%), Gaps = 8/210 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L + RL + +R Y DP ++ + + + + ++D+ + Sbjct: 5 LIPVLLVDQKR--RLVKTIEFGERTYVGDPFNVVRLFNEKEVDEICILDIDATRTGRGPD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ L +P+ GGG+ + L +GV + V+G A ++ +V G+ Sbjct: 63 LGFVRELATECFMPLAYGGGITELKQCEELNRSGVEKFVLGQGA-RNSQLVGAIAADMGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ALV +DV A SG ++ + G+ ++ + DGT G Sbjct: 122 QALVACVDVDGRGAAASCYASSGARQ----EPIEFCLRLQDAGVGEIILQSKTLDGTRNG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 ++ L + + + + + GG GD+ + Sbjct: 178 YDLELIQSITRKLS-IPVVALGGAGDVAHL 206 >UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oceani RepID=Q3JEF8_NITOC Length = 235 Score = 137 bits (346), Expect = 3e-31, Method: Composition-based stats. Identities = 50/245 (20%), Positives = 90/245 (36%), Gaps = 26/245 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN------DPLPRLQDYAAQG-AEVLHLVDLTGA 54 ++P LDL G VV G + PL + + L++ DL Sbjct: 3 LLPVLDLWGGVVVHARGGQRDSYLPLNSPFAPNSSPLQVVAGLLQWCRFQQLYIADLNAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + + ++ + V GG E VA L GVAR VVG+ + + Sbjct: 63 MGDGNNHFMIAAIARSYPDLELWVDGGTARHEAVAQLFALGVARPVVGTETLPDLESW-Q 121 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 + + L L++D R ++ + V+ + Sbjct: 122 ALQSSWPEQLALSMDHRRGAFLGP----------------AGLDRQPELWPGTVIAMSLD 165 Query: 175 RDGTLAGSNVSLYEEVCARY--PQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 + G+ G + SL E + R +++ ++GG+ ++D+ L GV GV++ AL +G Sbjct: 166 QIGSQQGPDWSLLERLGQRSLRKRISLLAAGGVRCLEDLKQLAAWGVEGVLLASALHDGS 225 Query: 233 FTVKE 237 E Sbjct: 226 LNPAE 230 >UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9303 RepID=A2CB98_PROM3 Length = 266 Score = 135 bits (340), Expect = 2e-30, Method: Composition-based stats. Identities = 32/182 (17%), Positives = 82/182 (45%), Gaps = 3/182 (1%) Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVG 102 + L ++D++ K ++R ++K L + +P+ GGG+ S + L ++G ++++ Sbjct: 49 IDELLVIDVSRKKRNSQRFCSMLKKLSSDCFLPIGAGGGLDSLDKAKMLFDSGADKLILN 108 Query: 103 STAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVE-TYL 161 ++ ++ +++K + +G A++ ++D++ +E G + + + SL+ Sbjct: 109 TSVYENPELIKALNKFYGQQAIIASVDIKKNELGIFDIYTHNGTKKAS-SLKDYQNIICK 167 Query: 162 PVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVR 220 + + + RDGT G + ++ + + +GG G + L GV Sbjct: 168 NEWIGELYLNSMERDGTGQGYDFNMLKSFTNLNKKHPIILAGGAGKTSHIVEGLLTDGVD 227 Query: 221 GV 222 Sbjct: 228 AC 229 >UniRef50_Q1PLA2 Putative cyclase hisF n=1 Tax=uncultured Prochlorococcus marinus clone ASNC1363 RepID=Q1PLA2_PROMA Length = 268 Score = 134 bits (338), Expect = 3e-30, Method: Composition-based stats. Identities = 41/182 (22%), Positives = 83/182 (45%), Gaps = 5/182 (2%) Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVG 102 + L ++D+T + ++ ++ + + VP+ +GGG+ S E ++G +V + Sbjct: 48 IDELLILDVTRGRKDSEEFCKVVTQISENIFVPLTIGGGINSLEKAKLFFKSGADKVSIN 107 Query: 103 STAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP 162 S+ + + +V + +G LV ++DV + + V + + SL + E Sbjct: 108 SSLL-DESLVTQIVKNYGKQCLVGSIDV-LKKNEEYYVYSNNGTKLVS-SLNKFFENKEF 164 Query: 163 V-GLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRG 221 + + I++DGT G ++SL E V A+ +V F SGG+G I D+ Sbjct: 165 FNNIGEIYINSINQDGTGNGLDISLAEFVSAK-SEVPFIISGGVGKITDIKDAFKYDFIN 223 Query: 222 VI 223 + Sbjct: 224 AV 225 >UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8LDL7_THAPS Length = 570 Score = 134 bits (337), Expect = 4e-30, Method: Composition-based stats. Identities = 42/269 (15%), Positives = 93/269 (34%), Gaps = 57/269 (21%) Query: 31 PLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIP---LIKTLVAGVNVPVQVGGGVRSEED 87 P+ Y +GA+ + +++T + +P +++ + VP+ VGGG+RS ED Sbjct: 293 PVSLASRYYKEGADEIAFLNITSFRSGVIEDMPMLQVLEEASKEIFVPLTVGGGIRSYED 352 Query: 88 ------------VAALLEAGVARVVVGSTAVKSQDM-------------VKGWFERFGAD 122 + AG +V +GS +V + + ++ +G Sbjct: 353 PGTGKVYSALEVASRYFRAGADKVSIGSDSVHAAEEYIASGNTKTGQTSIETISHVYGVQ 412 Query: 123 ALVLALDVRI---------------------------DEQGNKQVAVSGWQENSGVSLEQ 155 A+V+++D + ++ Q V G +E + Sbjct: 413 AVVISIDPKRVYVTSPDAADSKHTVVTLDDSQKGPNGEQYCWYQCTVKGGREARDICAVS 472 Query: 156 LVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-L 214 + + +G ++ I DG G + +L + V + + +S G G + Sbjct: 473 VAKAAEALGAGEIMLNCIDMDGQCNGFDHALMKAV-SDAVTIPVIASSGAGKESHFSDVF 531 Query: 215 RGTGVRGVIVGRALLEGKFTVKEAIACWQ 243 T V+ + + + + + Sbjct: 532 SETSVQAALAAGMFHRKEVEIADVKKHME 560 >UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PRW0_MALGO Length = 576 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 53/324 (16%), Positives = 106/324 (32%), Gaps = 97/324 (29%) Query: 17 HQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD---PAKRQIPLIKTLVAGVN 73 G + R+ G P+ Q Y +GA+ + +++T ++ + + L+ A + Sbjct: 248 RSGGKAQVRNMGK-PVELAQRYYEEGADEIAFLNITSFRNWALGDQPMLSLLNVAAATIF 306 Query: 74 VPVQVGGGVRS-----------EEDVAALLEAGVARVVVGSTAVKSQDM----------- 111 VP+ VGGG+R E A AG +V +GS AV + + Sbjct: 307 VPLTVGGGIRDFTDPDGTFHPALEVAHAYFRAGADKVSIGSEAVYAVEQLLQRATELGDC 366 Query: 112 -----------------VKGWFERFGADALVLALDVRIDEQGNKQV-------------- 140 ++ ++G A+V+++D + ++++ Sbjct: 367 TGDPCAAPAMALRGDTGIEQIAHKYGVQAVVVSVDPKRVYLSDQEIDGLSDEHSSGDGPV 426 Query: 141 --------------------------------AVSGWQENSGVSLEQLVETYLPVGLKHV 168 V G +E+ + + QL +G + Sbjct: 427 DARTHPHASSIVCGQDERPETAGQSARWWYMCTVKGGRESRDIDVVQLARGVERLGAGEL 486 Query: 169 LCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-------AALRGTGVRG 221 L I RDG+ AG + L ++ + +S G G D A RG + Sbjct: 487 LINSIDRDGSYAGFDEKLI-DLVRGCVNIPVIASSGAGCADHFCDVLASRPAARGAPIEA 545 Query: 222 VIVGRALLEGKFTVKEAIACWQNA 245 + + ++ + +A Sbjct: 546 ALAAGIFHRREVSIMDVKKRCADA 569 >UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales RepID=C9RDL3_METVM Length = 229 Score = 124 bits (311), Expect = 3e-27, Method: Composition-based stats. Identities = 52/252 (20%), Positives = 95/252 (37%), Gaps = 37/252 (14%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +D+ V G K + +DP+ + Y +G+E++++ DL A Sbjct: 3 IIPVIDIKGNIAVHGKSGMRSKYQPLKSVICETSDPICLAKSYKEKGSEMVYIADLD-AI 61 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEED---VAALLEAGVARVVVGSTAVKSQDMV 112 LIK + + V G+++ ED V L + ++ + + ++++ Sbjct: 62 CGEGDNFNLIKNID---FINKIVDAGIKTREDLERVREYLNKN-DKAIIATETLIDKELI 117 Query: 113 KGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTD 172 ++++LD + + N V L + D Sbjct: 118 SE-------KNIIVSLDFKDGKLLNYTVEEVLGLVRKDTPL---------------IILD 155 Query: 173 ISRDGTLAGSNVSLYEEVCARYPQV-AFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 IS GT G N+ L + GGI DI D+ G+ GV+VG A+ G Sbjct: 156 ISSVGTGRGINMKLINMILKLNKGKNPIYVGGGIRDITDIEKCYNLGIDGVLVGTAIHRG 215 Query: 232 KFTVKEAIACWQ 243 ++E I ++ Sbjct: 216 VIDLEEVIKKFE 227 >UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanococcales RepID=Y703_METJA Length = 226 Score = 121 bits (304), Expect = 2e-26, Method: Composition-based stats. Identities = 52/249 (20%), Positives = 100/249 (40%), Gaps = 41/249 (16%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL D V G+ + + ++P+ + Y +GA+ +++ DL Sbjct: 3 IIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNFIM 62 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEED---VAALLEAGVARVVVGSTAVKSQDMV 112 +IK + + V GV+S ED + +L R +V + +K +++ Sbjct: 63 GNGD-NFDIIKEID---FINKIVDIGVKSREDLETIKKVLNKD-DRAIVATETLKDIELL 117 Query: 113 KGWFERFGADALVLALDVRIDEQGNKQV--AVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 K +V++LD + N + +S ++++ + + Sbjct: 118 KE-------KDIVVSLDFKNGNLLNYSLDEILSCVRDDTPL-----------------II 153 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 DIS GT G N L + V + GGI ++D+ GV V++ A+ + Sbjct: 154 LDISSVGTQRGVNAELIKYVLDKTNN-PVYVGGGIKGMEDLELCYNLGVDAVLIATAIHK 212 Query: 231 GKFTVKEAI 239 G ++E I Sbjct: 213 GVLDLEEII 221 Score = 56.2 bits (135), Expect = 1e-06, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 35/75 (46%) Query: 46 LHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTA 105 L ++D++ LIK ++ N PV VGGG++ ED+ GV V++ + Sbjct: 151 LIILDISSVGTQRGVNAELIKYVLDKTNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAI 210 Query: 106 VKSQDMVKGWFERFG 120 K ++ +FG Sbjct: 211 HKGVLDLEEIINKFG 225 >UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococcus sp. FS406-22 RepID=D1SND3_9EURY Length = 237 Score = 120 bits (302), Expect = 5e-26, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 105/252 (41%), Gaps = 31/252 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL++ V G+ + + +P+ Y +GAE +++ DL Sbjct: 3 IIPVIDLMNKIAVHGKSGNRDEYKPLKSVICNSPNPIDVAMAYKERGAETIYIADLNFIM 62 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEED---VAALLEAGVARVVVGSTAVKSQDMV 112 +IK + V V GV+ ED + +L + +V + +K +++ Sbjct: 63 GNGD-NFEVIKEID---FVNKIVDIGVKRREDLENIKKILNKD-DKAIVATETLKDIELL 117 Query: 113 KGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTD 172 K +V++LD + + + +++ S + V P+ +L D Sbjct: 118 KE-------KDIVVSLDFK----NGELLLDKNFKDYSLDGILSYVREDTPL---TIL--D 161 Query: 173 ISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 IS GT G NV L + V + GGI +DD+ GV GV++ A+ +G Sbjct: 162 ISSVGTQRGINVELIKYVLDKTNN-PVYVGGGIKGMDDLELCYNLGVDGVLIATAIHKGI 220 Query: 233 FTVKEAIACWQN 244 ++E I+ + + Sbjct: 221 LDLEEIISKFSD 232 >UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole carboxamide isomerase family protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C36C9 Length = 235 Score = 120 bits (301), Expect = 6e-26, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 89/235 (37%), Gaps = 13/235 (5%) Query: 9 IDGTVVRLHQGDYGKQRDY------GNDPLPRLQDY-AAQGAEVLHLVDLTGAKDPAKRQ 61 ++G VVR GD R P Q + GA L++ DL A + R Sbjct: 1 MNGVVVRAVGGDRKNYRPVRSPLTPSTVPTDIAQALLRSVGAGELYVADLD-AITGSARV 59 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 P ++ L+ VPV + G DV R VVG + +++ Sbjct: 60 TPSVEALMEACAVPVWLDAG-TGRRDVLDWPPHQNLRPVVGFETCRVPEVLAEALLEPRQ 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +LD+R + W L + +G++ ++ D++R GT G Sbjct: 119 RPVAFSLDLRNGQLLGNW---RAWGLAGDRDALALTRRVVDMGVRTLIVLDLARVGTGTG 175 Query: 182 SNV-SLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 + L + A +P + + GG+ DV L G GV+V AL EG + Sbjct: 176 AGTDELVRVIRAEFPDLDLIAGGGVRTWSDVERLGKAGATGVLVASALHEGTLVL 230 >UniRef50_A8TGW8 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TGW8_METVO Length = 181 Score = 119 bits (299), Expect = 1e-25, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 59/134 (44%), Gaps = 1/134 (0%) Query: 79 GGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNK 138 GGG+++ E+ + + E G ++ + S + ++ + +G+ ++V ++DV+ + G Sbjct: 12 GGGIKTFEEASKIFELGFEKISLNSVLFEKPSLLTELSQSYGSQSIVASVDVKKNLFGKL 71 Query: 139 QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVA 198 +V + + V+ +G +L + +GT G N+SL E+ + Sbjct: 72 KVYNGSKNNSINDKILDYVKNLENLGAGELLINSVDLEGTYKGYNLSLINELSNALT-IP 130 Query: 199 FQSSGGIGDIDDVA 212 + GG D Sbjct: 131 LIALGGASSTKDFK 144 >UniRef50_B1LZS6 Histidine biosynthesis protein n=10 Tax=Alphaproteobacteria RepID=B1LZS6_METRJ Length = 243 Score = 110 bits (275), Expect = 6e-23, Method: Composition-based stats. Identities = 47/209 (22%), Positives = 86/209 (41%), Gaps = 23/209 (11%) Query: 28 GNDPLPRLQDYAAQ-GAEVLHLVDLTGAKDPAKRQIPLIKTLVAGV-NVPVQVGGGVRSE 85 G+ P + A +L++ DL D A + ++ + V + V G Sbjct: 48 GSAPDAVARGLRDAWPAAILYVADLDAIIDRAAPDLRALEAIARACPGVSLWVDAGFAEP 107 Query: 86 EDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGW 145 V A L +G+ R V+GS + D+V D V +LD R G +++ + Sbjct: 108 AAVDAFLASGLGRPVIGSESQADADLVTRL-----GDRAVFSLDTR----GAERLGPAAL 158 Query: 146 QENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGI 205 ++ + + V+ +++ G AG ++ + AR P ++GG+ Sbjct: 159 HDDPALWPPE------------VIAMTLAQVGAGAGPDLGALGALRARAPDRRLYAAGGV 206 Query: 206 GDIDDVAALRGTGVRGVIVGRALLEGKFT 234 DD+ ALR G+ G +V AL +G + Sbjct: 207 RGPDDLRALRAAGIAGALVASALHDGTLS 235 >UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C0W3_9PLAN Length = 247 Score = 106 bits (266), Expect = 6e-22, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 95/246 (38%), Gaps = 24/246 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQ-GAEVLHLVDLTGA 54 IIP LD+++ T+VR G + + PL Q + G ++ DL Sbjct: 3 IIPVLDILNQTIVRGIAGQRETYQPIQSGLTHSSQPLDIAQALQDEFGFSEFYVADLDAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + + + L+ + + G+ D L + +V G ++S +K Sbjct: 63 LQQRL-NLQMYQCLLDAGFTFL-LDCGLHFAGDSQPLSKMKGITIVAGLETLESPQELKQ 120 Query: 115 WFERFGADALVLALD------VRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHV 168 + +GA + V +LD VR N A+ ++ E L G+ + Sbjct: 121 LVQNWGAASTVFSLDLKQGKPVRNSSSDNPYAAID--------DPLEIAELSLQQGVNQM 172 Query: 169 LCTDISRDGTLAGSNVSLY-EEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 + D++ GT G+ + + +P + + GGI IDD+ G V+V A Sbjct: 173 ILLDLANVGTGQGTGTEALCRTLRSHHPDLRLITGGGIHSIDDLQTQAEQGADAVLVASA 232 Query: 228 LLEGKF 233 L +G+ Sbjct: 233 LHDGRL 238 >UniRef50_C0N3H2 Histidine biosynthesis protein n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N3H2_9GAMM Length = 237 Score = 106 bits (265), Expect = 7e-22, Method: Composition-based stats. Identities = 43/246 (17%), Positives = 89/246 (36%), Gaps = 32/246 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYG------KQRDYGNDPLPRLQ-DYAAQGAEVLHLVDLTGA 54 IIP +D+ G VV G+ D + E ++ DL Sbjct: 3 IIPVIDIRGGIVVHARGGNRDAYSALNSVLTRSTDVFQVVNDILNWYPFEQFYIADLDAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + R + + + G+ S++D+ + ++V+GS +KS +++ Sbjct: 63 EAAKHRPEFYAELVHCFTGTQFWLDAGITSQKDLRLYSKLHNLKIVIGSETLKSLSLLEI 122 Query: 115 WFERFGADALVLALDVRIDE---QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 R +++L+LD R + N W E + + Sbjct: 123 EGAR---QSMILSLDRRGKQLLGAHNLLHRTELWTEQT-------------------IVM 160 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 D+ G G ++ + + A+ P + + ++GG+ + D+ L+ G ++ AL G Sbjct: 161 DLDVIGANQGPSLEWLQALIAQRPDIEWYAAGGVRNKADLEQLQKIRAAGTLIASALHTG 220 Query: 232 KFTVKE 237 + E Sbjct: 221 QIDKAE 226 >UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobiales RepID=C6QGP7_9RHIZ Length = 235 Score = 105 bits (263), Expect = 1e-21, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 91/247 (36%), Gaps = 26/247 (10%) Query: 2 IIPALDLIDGTVVRLHQGDY------GKQRDYGNDPLPRLQDYAA-QGAEVLHLVDLTGA 54 IIP +D+ G VVR QG ++P + + ++ DL G Sbjct: 3 IIPVIDVSRGKVVRAIQGKRAAYLPIETPLAATSEPGDVARGLRSLYPFRRAYVADLDG- 61 Query: 55 KDPAKRQIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 + R L+ L + N + + G S A+L A VA +VVGS +++S Sbjct: 62 IEGRGRNTHLVPELSQALPNTELWIDAGTGSRSAARAVLAAPVATLVVGSESLESVRAWH 121 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 VL+LD R DE + L V+ + Sbjct: 122 EISAEAPG-RTVLSLDFRGDEFMGPEAL-----------LADAALW-----PTRVIVMTL 164 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 R + G N++L E + AR ++GGI ++D+A + G G +V L K Sbjct: 165 DRIASEGGPNIALLETIAARAGGRRVYAAGGIRSLEDLARIGKAGAAGALVASILHAQKI 224 Query: 234 TVKEAIA 240 + + Sbjct: 225 SAGDLKE 231 >UniRef50_Q1H0R8 Histidine biosynthesis n=1 Tax=Methylobacillus flagellatus KT RepID=Q1H0R8_METFK Length = 234 Score = 103 bits (257), Expect = 6e-21, Method: Composition-based stats. Identities = 58/247 (23%), Positives = 95/247 (38%), Gaps = 41/247 (16%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGA-------EVLHLVDLTGA 54 +IP +DL++G VV QG+ + ++ + GA L++ DL A Sbjct: 3 VIPVIDLMNGAVVHARQGNRAHYQPIVSNLCNGSEAQEIVGALLGLYPFPALYIADLD-A 61 Query: 55 KDPAKRQIPLIKTL-VAGVNVPVQVGGGVRSEEDVAAL----LEAGVARVVVGSTAVKSQ 109 LI TL + + V G+ S V L R V+G+ ++ S Sbjct: 62 IQCRNDHRTLIHTLLSKHPTLEIWVDAGINSVAKVQRWQHPRL-----RPVLGTESIPSI 116 Query: 110 ---DMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLK 166 ++ G E +L+LD +G+Q S L Q + Sbjct: 117 ATWHLLAGACEG----RHILSLD----------FTTAGYQGPSE--LLQEARHWPQ---- 156 Query: 167 HVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGR 226 HV+ + G+ AG ++ A P+ ++GGI D D+ LR G++G +V Sbjct: 157 HVIIMSLPHVGSHAGPDMDKLTHFRALSPKHHLYAAGGIRDASDLQLLRKRGIKGALVAS 216 Query: 227 ALLEGKF 233 AL G Sbjct: 217 ALHNGNL 223 >UniRef50_Q603E0 Putative HisA/HisF family protein n=1 Tax=Methylococcus capsulatus RepID=Q603E0_METCA Length = 227 Score = 100 bits (250), Expect = 4e-20, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 93/243 (38%), Gaps = 33/243 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN------DPLPRLQDYAA-QGAEVLHLVDLTGA 54 IIP LDL+ G VV +G R + DP ++ + + ++ DL Sbjct: 3 IIPVLDLMQGRVVHAVKGRRENYRPLSSPLCPDADPRAVVEAFRNLYRFDTFYIADLDAL 62 Query: 55 KDPAKRQIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 + LI L ++ + G+ E A L+ GV V+GS ++ + D ++ Sbjct: 63 MGLGCQN-ELIAALRTAFPDIVFWLDRGL--PEAGEAALD-GVV-PVIGSESLPTVDRLQ 117 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 R +L+LD G + L Q + V+ + Sbjct: 118 RMTTR----DWILSLD-----------FFDGTLKGCSRLLAQ-----PQCWPERVIVMTL 157 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 +R G+ G ++ L + V P A ++GG+ D D+ L G+ V+V AL G Sbjct: 158 NRVGSFDGPDLDLLDRVRRLTPHRALIAAGGVRDAGDLEILERRGIHAVLVASALHSGSL 217 Query: 234 TVK 236 + Sbjct: 218 ELS 220 >UniRef50_A2SJ37 HisA/HisF family protein, putative n=3 Tax=Burkholderiales RepID=A2SJ37_METPP Length = 273 Score = 99.7 bits (248), Expect = 7e-20, Method: Composition-based stats. Identities = 60/246 (24%), Positives = 102/246 (41%), Gaps = 33/246 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGA-EVLHLVDLTGA 54 IIP +DL+DG VVR +G+ R DP + A + L+L DL A Sbjct: 3 IIPVIDLLDGQVVRAVRGERRHYRAIASALCGSADPRIVARRLCEHCATDTLYLADLN-A 61 Query: 55 KDPAKRQIPLIKTLVA-GVNVPVQVGGGVRSEEDVAALLE----AGVARV--VVGSTAVK 107 Q+ ++TL+ ++ + + G +D A LL ARV V GS +++ Sbjct: 62 LQGRPPQLEWLRTLLQDRPDLALWLDAGFSGPDDAAHLLARLEPTAAARVTPVYGSESLR 121 Query: 108 SQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 S++ + F +L+LD R + + +L + + Sbjct: 122 SRETLAACFA--PPSRALLSLDHRQGAPLD------------PAGVWELPAQWP----RR 163 Query: 168 VLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 ++ +SR G+ G ++ V AR P +GG+ D D+AA + G +V A Sbjct: 164 LIVMTLSRVGSDGGPDLDTLAAVRARAPHAQLIGAGGVRDAADLAAAQAAGAHAWLVASA 223 Query: 228 LLEGKF 233 L +G+ Sbjct: 224 LHDGRL 229 >UniRef50_D2MIW0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Poribacteria sp. WGA-A3 RepID=D2MIW0_9BACT Length = 104 Score = 99.7 bits (248), Expect = 7e-20, Method: Composition-based stats. Identities = 35/104 (33%), Positives = 56/104 (53%), Gaps = 3/104 (2%) Query: 142 VSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQS 201 + GW S + E ++ + L V+ T+ISRDG L G NV+ + P V + Sbjct: 1 MHGWTNVSESTAEPVLASLKEYPLAGVIFTEISRDGMLEGPNVAALRDAVRASP-VPLIA 59 Query: 202 SGGIGDIDDVAALRGTG--VRGVIVGRALLEGKFTVKEAIACWQ 243 SGG+ ++D+ A++ G + GVIVG+AL EG + A+A + Sbjct: 60 SGGVTRVEDIRAIKRLGQKIIGVIVGKALYEGTLDLPAALAEAR 103 >UniRef50_Q6R3H4 Conserved protein n=1 Tax=Methylosinus sp. LW2 RepID=Q6R3H4_9RHIZ Length = 230 Score = 99.4 bits (247), Expect = 9e-20, Method: Composition-based stats. Identities = 50/249 (20%), Positives = 86/249 (34%), Gaps = 43/249 (17%) Query: 2 IIPALDLIDGTVVRLHQGDYGK------QRDYGNDPLPRLQDYAA-QGAEVLHLVDLTGA 54 +IP +D+ +G VR GD +DPL + E +++ DL Sbjct: 3 VIPVIDIRNGVAVRAVAGDRKNYAPLTTPLAATSDPLDVARGLMTLHPFEAIYVADLDAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVAR------VVVGSTAVKS 108 + + + A + + G LE G R V GS ++ Sbjct: 63 ERRGNNRTSIAAIAKAIAPARLWLDAG------FTGALEVGAWRSLENVDPVFGSETLQE 116 Query: 109 QDMVKGWFERFGADALVLALDVRIDEQ-GNKQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 D ++ +L+LD G+ ++ Sbjct: 117 SDDLRA------DKHAILSLDFSTRSFLGDPRLYDD-----------------ESFWPDR 153 Query: 168 VLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 ++ +SR G G +VS + +V AR ++GG +DD+ L+ G G +V A Sbjct: 154 LIVMTLSRVGAKQGPDVSRFYDVAARAGSRQVCAAGGARGLDDLLVLKEAGAAGALVATA 213 Query: 228 LLEGKFTVK 236 L EG+ T Sbjct: 214 LHEGRLTPA 222 >UniRef50_A3PE78 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9301 RepID=A3PE78_PROM0 Length = 222 Score = 99.0 bits (246), Expect = 1e-19, Method: Composition-based stats. Identities = 34/188 (18%), Positives = 78/188 (41%), Gaps = 11/188 (5%) Query: 40 AQGAEVLHLVDLTGAKDPAKRQIPLIKTLV---AGVNVPVQVGGGVRSEEDVAALLEAGV 96 A ++ + +++L+ + + +P+ +GG +RS E+ L G Sbjct: 11 ANCSDEILIINLSEKNWEEAYNNKFFNDISLLLSKTFLPITIGGKIRSIENAKELFNFGA 70 Query: 97 ARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQL 156 ++++ + Q+++K + +G ++V+ D+ N + ++ E +L+++ Sbjct: 71 DKILISRAFFQDQNLLKEIRDLYGVQSIVVQFDI---NSQNYDIFINSSLEKVS-NLKKI 126 Query: 157 VETYLPVGL-KHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-L 214 V + L ++ I RDGT G N + + +SGG G +A L Sbjct: 127 VYSLNEKNLMGELIINQIDRDGTGFGHNTEYLNAIPKL--NMPLIASGGFGSSIHMAECL 184 Query: 215 RGTGVRGV 222 + + V Sbjct: 185 KFDSISAV 192 >UniRef50_D1JF95 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=uncultured archaeon RepID=D1JF95_9ARCH Length = 238 Score = 99.0 bits (246), Expect = 1e-19, Method: Composition-based stats. Identities = 43/242 (17%), Positives = 99/242 (40%), Gaps = 23/242 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGK--------QRDYGNDPLPRLQDYAAQGAEVLHLVDLTG 53 +I +DL+DG VV +G+ K +DP + + +++ DL Sbjct: 5 LIFVMDLLDGVVVHAKRGEREKYVPIHRFSSIVTSSDP---ARVIETIKPKEVYIADLNR 61 Query: 54 AKDPAKRQIPLIKTLV-AGVNVPVQVGGGVRSEEDVAALLEAG-VARVVVGSTAVKSQDM 111 P++K L ++ + + GV+ ED+ ++A + V+G+ + S ++ Sbjct: 62 LLSTG-NNRPILKDLRTRNRDLRIMLDYGVKGMEDLKEAVDAEMADKFVLGTETI-SIEL 119 Query: 112 VKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 ++ + + + + N +V S + + +L++ ++ V+ Sbjct: 120 LEEASKSDIITDISI-----SIDLFNNEVLTSDTRMK--IDPLRLIKELNKFPVRDVIVL 172 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 +++R GT +G + + GG+ + +DV + GV+G +V A+ +G Sbjct: 173 ELNRVGTKSGIDFEFLAR-AVELSEHDILCGGGVRNCEDVHKMAEIGVKGALVATAIHDG 231 Query: 232 KF 233 Sbjct: 232 GI 233 >UniRef50_C6XDW4 Histidine biosynthesis protein n=1 Tax=Methylovorus sp. SIP3-4 RepID=C6XDW4_METSD Length = 232 Score = 96.3 bits (239), Expect = 8e-19, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 91/244 (37%), Gaps = 28/244 (11%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAA-QGAEVLHLVDLTGA 54 IIP +DL++ VV +G+ R + PL + + L++ DL A Sbjct: 3 IIPVIDLLEHHVVHAKRGERQHYRPIESGLCDSSQPLAITRALLELYPFDTLYIADLN-A 61 Query: 55 KDPAKRQIPLIKTLVAG-VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 + I + + + + G ++ D+ V V+GS ++ + Sbjct: 62 IQGKPAHVDEIALIRQHYPQLRIWLDAGFKNTRDLLPWSGLEVT-PVIGSESLPDIGAYQ 120 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 A VL+LD R D + + + + V+ + Sbjct: 121 ELISE--GVAHVLSLDFRGDRYQGPEALLDNPRLWPQL----------------VIGMTL 162 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + G+ G + + +++ +GG+ DI+D+ LR G+ G +V AL G+ Sbjct: 163 ANVGSNQGPDHARLQQLVGMAQHGKLYGAGGVRDINDLQRLREQGIAGALVASALHSGQI 222 Query: 234 TVKE 237 + ++ Sbjct: 223 SSQD 226 >UniRef50_Q0G4J3 HisA/HisF family protein, putative n=1 Tax=Fulvimarina pelagi HTCC2506 RepID=Q0G4J3_9RHIZ Length = 237 Score = 96.3 bits (239), Expect = 9e-19, Method: Composition-based stats. Identities = 55/245 (22%), Positives = 99/245 (40%), Gaps = 35/245 (14%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYA-AQGAEVLHLVDLTGA 54 +IP LDL++G VVR G R G +P+ + A G +V+++ DL A Sbjct: 10 LIPVLDLMNGLVVRGEGGRRESYRPIETPLADGAEPVAVARGLIGATGTDVMYVADLD-A 68 Query: 55 KDPAKRQIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLE---AGVARVV--VGSTAVKS 108 + Q+P+++ L ++ V G ++ + AL+ G R+V G+ + Sbjct: 69 IMGGEAQVPVLQALGEAFPDLRFWVDAGFQTIDAAEALIAAVALGAGRIVPVFGTETLDE 128 Query: 109 QDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHV 168 + + VL+LD G++ + L + E + V Sbjct: 129 TEALARM-----DGPAVLSLDFGA----------EGYRGSPA--LLEGAELWPAD----V 167 Query: 169 LCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRAL 228 + ++ G+ G + EE+ AR ++GG+ D+ AL GV G +V AL Sbjct: 168 VVMSLAAVGSSGGPDFQRLEEIVARAGTRRVHAAGGVRGRTDLDALAAMGVAGALVASAL 227 Query: 229 LEGKF 233 + Sbjct: 228 HNRRL 232 >UniRef50_A7IL67 Histidine biosynthesis protein n=2 Tax=Alphaproteobacteria RepID=A7IL67_XANP2 Length = 235 Score = 95.5 bits (237), Expect = 1e-18, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 90/244 (36%), Gaps = 32/244 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPR-LQDYAAQGAEVLHLVDLTGA 54 +IP +DL G VV +G+ R + PL A L++ DL A Sbjct: 3 LIPVVDLKGGYVVHARRGERDSYRPIHTPLAATSAPLDVVAGLLALAPFRTLYVADLD-A 61 Query: 55 KDPAKRQIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 +I L A + + V G + V A G V+G+ + K Sbjct: 62 IAGKGSHGAVIDGLRAAFPRLDLWVDAGEARADQVHARAAQGRGFCVIGTETLPDVAAAK 121 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 A ++L+LD V+V E+ + E V+ + Sbjct: 122 DVLA---AGDVILSLD-HDAAGPRGPVSVH---EDPALWPE------------RVIVMTL 162 Query: 174 SRDGTLAGSNVSLYEEVCARYPQV----AFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 +R G+ G +++ E AR + + ++GG+ +D+ L G GV+V AL Sbjct: 163 ARVGSGEGPDLAALERTAARADGIGRHPSLYAAGGVRGPEDLDRLAAMGTAGVLVASALH 222 Query: 230 EGKF 233 +G+ Sbjct: 223 DGRI 226 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 269 6e-71 UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 264 2e-69 UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 260 3e-68 UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 260 4e-68 UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 259 8e-68 UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 257 2e-67 UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 256 6e-67 UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 255 8e-67 UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 255 1e-66 UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 254 2e-66 UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 251 2e-65 UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 250 2e-65 UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 250 2e-65 UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 246 6e-64 UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 246 6e-64 UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 245 9e-64 UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 244 2e-63 UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 244 2e-63 UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 244 2e-63 UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 243 3e-63 UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 243 3e-63 UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 7e-63 UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 242 8e-63 UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 3e-62 UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 3e-62 UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 240 3e-62 UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 5e-62 UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 5e-62 UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 5e-62 UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 239 6e-62 UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hi... 239 7e-62 UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 9e-62 UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 1e-61 UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 1e-61 UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 1e-61 UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 238 2e-61 UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxa... 237 2e-61 UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 237 2e-61 UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 237 3e-61 UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 237 3e-61 UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 3e-61 UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 4e-61 UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 4e-61 UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 4e-61 UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 4e-61 UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 236 5e-61 UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 235 1e-60 UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 234 2e-60 UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hi... 234 2e-60 UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hi... 234 3e-60 UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hi... 234 3e-60 UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 3e-60 UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 4e-60 UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 5e-60 UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 233 6e-60 UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 232 7e-60 UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 232 7e-60 UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 232 8e-60 UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxa... 231 1e-59 UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxa... 231 1e-59 UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=... 231 2e-59 UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 231 2e-59 UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 2e-59 UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 3e-59 UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 3e-59 UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 3e-59 UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 4e-59 UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 230 5e-59 UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 228 9e-59 UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 227 2e-58 UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 5e-58 UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 5e-58 UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 5e-58 UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hi... 226 6e-58 UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 6e-58 UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole... 226 6e-58 UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole ... 226 7e-58 UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 226 7e-58 UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 225 9e-58 UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 225 1e-57 UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 225 1e-57 UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxa... 225 1e-57 UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 2e-57 UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 2e-57 UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 2e-57 UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 224 2e-57 UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hi... 223 4e-57 UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 223 6e-57 UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 222 9e-57 UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 1e-56 UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 221 2e-56 UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxa... 220 2e-56 UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hi... 220 4e-56 UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 220 4e-56 UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 219 7e-56 UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hi... 218 1e-55 UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 217 2e-55 UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 217 2e-55 UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 216 4e-55 UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomyc... 216 7e-55 UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 215 8e-55 UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 215 1e-54 UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 215 1e-54 UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 214 2e-54 UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 3e-54 UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 213 3e-54 UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hi... 211 1e-53 UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hi... 211 1e-53 UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 211 2e-53 UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hi... 211 2e-53 UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 210 2e-53 UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 210 3e-53 UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 210 5e-53 UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hi... 209 7e-53 UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanae... 208 9e-53 UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 1e-52 UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 208 2e-52 UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hi... 206 4e-52 UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hi... 206 4e-52 UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 5e-52 UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 6e-52 UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 206 8e-52 UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hi... 205 1e-51 UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hi... 205 2e-51 UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hi... 204 2e-51 UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hi... 204 3e-51 UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 203 3e-51 UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hah... 203 5e-51 UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hi... 202 8e-51 UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hi... 201 1e-50 UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovi... 201 2e-50 UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winog... 201 2e-50 UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hi... 201 2e-50 UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillon... 200 4e-50 UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococ... 200 5e-50 UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 198 1e-49 UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spir... 198 1e-49 UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase su... 198 1e-49 UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 197 2e-49 UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Pro... 196 5e-49 UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collins... 195 1e-48 UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazol... 195 1e-48 UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfati... 195 1e-48 UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, c... 195 1e-48 UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hi... 195 1e-48 UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hi... 194 2e-48 UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 194 2e-48 UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hi... 194 3e-48 UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase su... 193 4e-48 UniRef50_P72139 Putative imidazole glycerol phosphate synthase s... 193 7e-48 UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase s... 191 2e-47 UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Pro... 190 4e-47 UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hi... 189 4e-47 UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase s... 189 5e-47 UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter... 189 9e-47 UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria ... 188 2e-46 UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase s... 188 2e-46 UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picr... 187 3e-46 UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase s... 185 1e-45 UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 185 1e-45 UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter... 184 2e-45 UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 183 4e-45 UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Pr... 183 4e-45 UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanae... 183 5e-45 UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 183 6e-45 UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 181 1e-44 UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 180 3e-44 UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxa... 179 6e-44 UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 178 2e-43 UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hi... 176 4e-43 UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 176 8e-43 UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosyl... 176 9e-43 UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 175 1e-42 UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3... 174 2e-42 UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase su... 174 2e-42 UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase s... 174 3e-42 UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobact... 173 6e-42 UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C... 173 6e-42 UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiel... 172 1e-41 UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_Y... 170 4e-41 UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine... 169 7e-41 UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovi... 167 3e-40 UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii H... 166 7e-40 UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxa... 166 9e-40 UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase su... 165 1e-39 UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 165 1e-39 UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 164 2e-39 UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hi... 164 2e-39 UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Me... 164 3e-39 UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes:... 163 6e-39 UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 163 6e-39 UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID... 163 6e-39 UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis... 163 7e-39 UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit Hi... 162 9e-39 UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacte... 162 1e-38 UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oce... 161 2e-38 UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase su... 160 4e-38 UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methano... 159 9e-38 UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicr... 158 2e-37 UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms Re... 156 9e-37 UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 155 1e-36 UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole ... 154 3e-36 UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n... 152 1e-35 UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepI... 152 1e-35 UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planc... 151 1e-35 UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase su... 151 2e-35 UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales... 151 2e-35 UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase s... 151 2e-35 UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirg... 150 3e-35 UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlo... 150 4e-35 UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methano... 149 6e-35 UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanoco... 149 7e-35 UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococ... 148 2e-34 UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxa... 147 3e-34 UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 147 4e-34 UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobial... 146 5e-34 UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogen... 146 6e-34 UniRef50_C0N3H2 Histidine biosynthesis protein n=1 Tax=Methyloph... 144 2e-33 UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=La... 144 2e-33 UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. ... 142 6e-33 UniRef50_Q1H0R8 Histidine biosynthesis n=1 Tax=Methylobacillus f... 141 3e-32 UniRef50_B2JX56 Histidine biosynthesis protein n=6 Tax=Burkholde... 140 5e-32 UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase s... 139 8e-32 UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malasse... 139 8e-32 UniRef50_Q603E0 Putative HisA/HisF family protein n=1 Tax=Methyl... 139 9e-32 UniRef50_C6XDW4 Histidine biosynthesis protein n=1 Tax=Methylovo... 138 1e-31 UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit H... 136 4e-31 UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)m... 136 5e-31 UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanoco... 132 7e-30 UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxa... 132 7e-30 UniRef50_Q6R3G3 Conserved protein n=1 Tax=Methylomonas sp. LW13 ... 132 8e-30 UniRef50_Q6R3H4 Conserved protein n=1 Tax=Methylosinus sp. LW2 R... 132 1e-29 UniRef50_A2SJ37 HisA/HisF family protein, putative n=3 Tax=Burkh... 131 2e-29 UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase Hi... 131 2e-29 UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlo... 131 2e-29 UniRef50_C4ZG69 APG10 (Albino and pale green 10); 1-(5-phosphori... 131 3e-29 UniRef50_O82782 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 130 3e-29 UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxa... 130 4e-29 UniRef50_Q2FS89 Histidine biosynthesis n=1 Tax=Methanospirillum ... 129 6e-29 UniRef50_C1ZC07 HisA/hisF family protein n=1 Tax=Planctomyces li... 129 8e-29 UniRef50_A7IL67 Histidine biosynthesis protein n=2 Tax=Alphaprot... 129 1e-28 UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 T... 128 2e-28 UniRef50_Q10184 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m... 127 2e-28 Sequences not found previously or not previously below threshold: >UniRef50_A7FJH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=97 Tax=Gammaproteobacteria RepID=HIS4_YERP3 Length = 245 Score = 269 bits (688), Expect = 6e-71, Method: Composition-based stats. Identities = 194/244 (79%), Positives = 221/244 (90%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALDLI+G VVRLHQGDYG+QRDYGN PLPRLQDY QGA+VLHLVDLTGAKDPA R Sbjct: 1 MIIPALDLIEGKVVRLHQGDYGQQRDYGNHPLPRLQDYQQQGAQVLHLVDLTGAKDPAAR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 QIPL++ L+AGV+VPVQVGGG+R+E+DV ALLEAG ARVVVGSTAVK +MV+ WFER+G Sbjct: 61 QIPLLRELLAGVDVPVQVGGGIRNEQDVVALLEAGAARVVVGSTAVKQPEMVQQWFERYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+A+VLALDVRI+E G K VA+SGWQENS +LEQ+VE YLP GLKHVLCTDISRDGTL+ Sbjct: 121 AEAIVLALDVRINEAGCKHVAISGWQENSDATLEQIVEQYLPYGLKHVLCTDISRDGTLS 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 GSNV LY+EVC RYPQVAFQ+SGGIG +DD+A LRG+GV+GVIVGRALL+GKF VKEAIA Sbjct: 181 GSNVELYQEVCQRYPQVAFQASGGIGCLDDIARLRGSGVQGVIVGRALLDGKFNVKEAIA 240 Query: 241 CWQN 244 CWQN Sbjct: 241 CWQN 244 >UniRef50_B0TY42 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_FRAP2 Length = 241 Score = 264 bits (675), Expect = 2e-69, Method: Composition-based stats. Identities = 111/240 (46%), Positives = 155/240 (64%), Gaps = 1/240 (0%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DLI+G VRL +GD+ K Y +P + Y GAE +H+VDL GAK Q Sbjct: 3 IFPAIDLINGKCVRLEKGDFNKTTTYELEPKDVAKAYQQAGAEFIHVVDLDGAKKGQTCQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ + N+ +QVGGGV+ E + LLE GV RVV+GS AVK + K +FE++GA Sbjct: 63 FETIQKIRENCNMTLQVGGGVKDFETIEKLLEIGVDRVVIGSLAVKDIALTKKFFEKYGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +VLALDV + G +A GWQE+S +L+++++TYL GL++VLCTDISRDG L G Sbjct: 123 EKIVLALDV-FIKNGVPYIATHGWQESSTTTLDEILQTYLGDGLEYVLCTDISRDGMLQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N LY + YP V F +SGG+G ++D+ L+ GVI+G+AL E KFT++EA+ C Sbjct: 182 PNFELYRIYSSIYPDVQFMASGGVGSLEDLEILKEQNTYGVIIGKALYENKFTLQEALEC 241 >UniRef50_Q47XB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Alteromonadales RepID=HIS4_COLP3 Length = 261 Score = 260 bits (665), Expect = 3e-68, Method: Composition-based stats. Identities = 137/242 (56%), Positives = 178/242 (73%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IPA+DLI G VVRL+QGDY ++ +Y R Q YA GA V+H VDL GAKD KR Sbjct: 1 MMIPAIDLIGGEVVRLYQGDYAQKTNYQYTVQDRQQAYAESGATVMHFVDLDGAKDSTKR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ +KT+V ++ +QVGGGVR E+DV LL G RVV+GS A+K ++V W + +G Sbjct: 61 QLKTLKTVVNHPSMIIQVGGGVRCEDDVKQLLALGADRVVIGSLAIKQPELVTQWVKTYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VLALD++ID QGNK + GW E+SGV+LE L+ Y G+KHVLCTDIS+DGTL Sbjct: 121 CEKIVLALDIKIDAQGNKTLPTHGWIEDSGVNLEDLLAQYQDAGIKHVLCTDISKDGTLT 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+NV LY EVCA+YP + +Q+SGGIG + D+ AL TGV GVI+GR+LLEGKFT++EAIA Sbjct: 181 GTNVDLYSEVCAKYPDIDWQASGGIGSLADIKALIPTGVSGVILGRSLLEGKFTLEEAIA 240 Query: 241 CW 242 CW Sbjct: 241 CW 242 Score = 45.5 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 40/97 (41%), Gaps = 1/97 (1%) Query: 28 GNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL-VAGVNVPVQVGGGVRSEE 86 G + L Y G + + D++ + L + ++ Q GG+ S Sbjct: 150 GVNLEDLLAQYQDAGIKHVLCTDISKDGTLTGTNVDLYSEVCAKYPDIDWQASGGIGSLA 209 Query: 87 DVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADA 123 D+ AL+ GV+ V++G + ++ + ++ + + Sbjct: 210 DIKALIPTGVSGVILGRSLLEGKFTLEEAIACWPKTS 246 >UniRef50_A0AG16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Bacteria RepID=HIS4_LISW6 Length = 240 Score = 260 bits (664), Expect = 4e-68, Method: Composition-based stats. Identities = 84/244 (34%), Positives = 134/244 (54%), Gaps = 7/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL +G VRL QGD+ K+ DP+ + + +A GA LH+VDL GA + Sbjct: 3 IFPAIDLKNGQCVRLFQGDFSKKMIVNEDPIAQAKAFATGGATYLHIVDLDGALEGRPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + VPVQVGGG+RS V L++G+ RV++GS A+ + D + +++G Sbjct: 63 LEIIQKMKEAATVPVQVGGGIRSLAQVDYYLDSGIDRVIIGSAALTNPDFLHAAVQKYGP 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + N VA SGW E S V+ L + VG++ ++ TDISRDGTL G Sbjct: 123 -KIAVGIDAK-----NGYVATSGWLEVSQVNYLDLAKQMEKVGVETIIYTDISRDGTLTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N+ + ++ + +SGG+ D+ AL G+ G I G+AL G ++ + Sbjct: 177 PNLEQMAAL-QKHVNIHLIASGGVSSRADLEALSQLGLYGAIAGKALYNGHISMSDVTEV 235 Query: 242 WQNA 245 +A Sbjct: 236 ENHA 239 >UniRef50_C4Z0A8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Clostridiales RepID=C4Z0A8_EUBE2 Length = 362 Score = 259 bits (662), Expect = 8e-68, Method: Composition-based stats. Identities = 80/243 (32%), Positives = 141/243 (58%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ DG VRL +G + + Y P + + GA+ +H VDL GA Sbjct: 3 LYPAIDVKDGQCVRLKKGLFNEVTVYSERPYEIAKGFEEAGAQFIHTVDLDGALKGHGVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + + VNVPVQ+GGG+R+ E++ +L+ GV RV++G+ AV++ D +K +RFGA Sbjct: 63 AETIKKICSSVNVPVQMGGGIRTLENIQEVLDLGVYRVIIGTKAVENPDFIKAAIDRFGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V+ +D + + VA+ GW++ S + L +G++ ++ TDIS+DG LAG Sbjct: 123 EHIVVGVDAK-----DGLVAIEGWEKVSDKTALSLALAMKDIGVQTIVYTDISKDGMLAG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV ++ + + +SGG+ +DD+ + G+ G I+G+A+ E + +KEA+ Sbjct: 178 PNVEQT-KILSDKTGIDIIASGGMSCMDDLTHINDAGIHGAIIGKAIYEKRIDLKEAVNL 236 Query: 242 WQN 244 +++ Sbjct: 237 FES 239 >UniRef50_Q1PWX6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1PWX6_9BACT Length = 243 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 76/244 (31%), Positives = 128/244 (52%), Gaps = 7/244 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL G VRL QG ++ + +DP+ + + QGA+ LH+VDL GA D + Sbjct: 2 IIFPAIDLKGGKCVRLTQGKKDEETVFSDDPVDMAKSWEDQGAQYLHVVDLDGAFDGLPK 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ +V +N+P++ GGG+R+ E V ++L+ GV RV++G+ A+ S V+ F Sbjct: 62 NLSIVEQIVNNINIPIEFGGGLRTTESVKSVLDLGVERVIIGTKALDSPSWVEELCSLFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +D + N +VAV GW S + ++ TDIS+DG L Sbjct: 122 G-RVAVGIDAK-----NGKVAVHGWTSLSEKTAIDFAREMEKFSPCAIIFTDISKDGMLQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ +E+ + + +SGGI + D+ + V G+IVG+AL G EA Sbjct: 176 GPNIESLKELLSSI-KTPVIASGGISSLKDIEYICQLPVEGMIVGKALYTGHIKFSEAKQ 234 Query: 241 CWQN 244 + Sbjct: 235 LCDS 238 >UniRef50_B8D115 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Halothermothrix orenii H 168 RepID=HIS4_HALOH Length = 237 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 83/235 (35%), Positives = 139/235 (59%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG+ VRL +GD+ K+R Y P+ + GA LH+VDL GAK Sbjct: 3 VIPAVDIKDGSCVRLKKGDFNKRRVYSTSPVDVALYWEKHGASRLHIVDLDGAKSGWPTH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + I+ + VN+P+QVGGG+RS + + L++GV R+++G+ A+K+ ++VK + FG+ Sbjct: 63 LKTIREIALRVNIPLQVGGGIRSLKVIKKYLDSGVDRIILGTVALKNPELVKRALDNFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +V+ +D R +VA GW + S V++E ++ VG+K + TDI+RDG L G Sbjct: 123 NRIVVGVDAR-----GGKVATEGWLKTSQVTVEDIISEMEEVGVKTFIYTDINRDGMLKG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 ++ + V + + +SGGI D+ L+ G++ IVG+AL EG ++ Sbjct: 178 PDIEGIKRVL-KSTKARIIASGGISSRQDLINLKAIGIKAAIVGKALYEGNLPLE 231 >UniRef50_Q2S296 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Salinibacter ruber DSM 13855 RepID=HIS4_SALRD Length = 258 Score = 256 bits (654), Expect = 6e-67, Method: Composition-based stats. Identities = 88/247 (35%), Positives = 143/247 (57%), Gaps = 9/247 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ DG VRLHQGDY + Y DP+ + + Q A+ LH+VDL A+ + Sbjct: 3 LVIPAIDIRDGRCVRLHQGDYDNETVYFEDPVKMAKLWRVQNAQTLHVVDLDAARGEGEH 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + +++P+Q+GGG+RS + + A L+ GV RV++G+ AV++ D V+ E+F Sbjct: 63 NRDVIGKMCDALDIPIQLGGGIRSMDQIEAALDRGVYRVILGTAAVRNPDFVERAVEQFS 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A +V+++D R + +V V GW E SG+ + G++ ++ TDISRDGT+ Sbjct: 123 ARRVVVSIDAR-----DGEVRVQGWTEGSGLDAVAFAKDMEQRGVRRLVYTDISRDGTMD 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDID---DVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N+ Y + + +SGG+G+ D D+ L+ GV VIVG AL E +F ++ Sbjct: 178 GPNIQAYRTLGRQLAHAKVTASGGVGEHDDLLDIQTLQPYGVDSVIVGTALYENRFPCQQ 237 Query: 238 AIACWQN 244 WQ+ Sbjct: 238 -FWAWQD 243 >UniRef50_A3N3W4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=92 Tax=Proteobacteria RepID=HIS4_ACTP2 Length = 250 Score = 255 bits (653), Expect = 8e-67, Method: Composition-based stats. Identities = 169/244 (69%), Positives = 199/244 (81%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPALDLIDG VVRLHQGDY KQ Y ++P+ + +Y AQGAE LHLVDLTGAK PAKR Sbjct: 6 IIIPALDLIDGNVVRLHQGDYAKQTTYSDNPIEQFANYLAQGAEQLHLVDLTGAKYPAKR 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI ++A N +QVGGG+R+E+DVA LL G RVV+GSTAVK + MVKGWFE++G Sbjct: 66 QTALIGKIIAETNCQIQVGGGIRTEQDVADLLAVGANRVVIGSTAVKDRAMVKGWFEKYG 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ VLALDV ID G K +A+SGWQE SGVSLE+L+E Y VGL+HVLCTDISRDGTLA Sbjct: 126 AEKFVLALDVNIDASGQKIIAISGWQEASGVSLEELIEDYQVVGLQHVLCTDISRDGTLA 185 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 GSNV+LY E+CA+YP++ FQSSGGIG +DD+ AL+GTGV GVIVGRALLEGKF V EAI Sbjct: 186 GSNVNLYREICAKYPKIHFQSSGGIGSLDDIKALKGTGVSGVIVGRALLEGKFNVAEAIE 245 Query: 241 CWQN 244 CWQN Sbjct: 246 CWQN 249 >UniRef50_Q3ZYM9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=15 Tax=root RepID=HIS4_DEHSC Length = 244 Score = 255 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 88/241 (36%), Positives = 137/241 (56%), Gaps = 7/241 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++ G VRL QGDY ++ Y +DP+ + + GA LH+VDL GA D Sbjct: 10 IIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQSVN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LIK + +PV+VGGG+RS E V LL AGV RV++G+ AV++ ++VK R+ A Sbjct: 70 FELIKEIANSALIPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICARY-A 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D++ +++D R N +VA GW N+ + +L + +G++ + TDISRDGTL+ Sbjct: 129 DSVAVSIDAR-----NGKVATRGWVTNTEIDALELARSMKKLGIRRFIYTDISRDGTLSE 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + ++ + V +SGG+ + + L+ G G IVG+A+ G +K A Sbjct: 184 PNFAAIRDLIS-AINVPVIASGGVSSLSHLRLLKDIGAEGAIVGKAIYTGDLNLKRAFED 242 Query: 242 W 242 Sbjct: 243 L 243 Score = 53.2 bits (127), Expect = 8e-06, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 43/122 (35%), Gaps = 1/122 (0%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 ++ A+D+ + + +G + D+ N Sbjct: 10 IIPAIDILGGRCVRLFQGDYAQETVYSSDPVGTAMRWQSLGAPRLHVVDLDGAADGQSVN 69 Query: 184 VSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQ 243 L +E+ + + GGI ++ V L GV VI+G A +E VKE A + Sbjct: 70 FELIKEIANSAL-IPVEVGGGIRSMETVKKLLVAGVDRVILGTAAVENPELVKEICARYA 128 Query: 244 NA 245 ++ Sbjct: 129 DS 130 >UniRef50_D0MJ01 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodothermus marinus DSM 4252 RepID=D0MJ01_RHOM4 Length = 266 Score = 254 bits (650), Expect = 2e-66, Method: Composition-based stats. Identities = 90/247 (36%), Positives = 138/247 (55%), Gaps = 10/247 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ G VRL+QG Y ++ Y +DP+ + Q A VLH+VDL A+ Sbjct: 3 LVIPAIDIRGGRCVRLYQGSYERETVYFDDPVKMACLWRVQNARVLHVVDLDAAR-GQGH 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + V++P+QVGGGVR+ ED+ ALL+ GV RVV+G+ AV+ ++V R+G Sbjct: 62 NREVIGAICRTVDIPIQVGGGVRTLEDIEALLQVGVYRVVLGTAAVREPELVSEAIARYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D R + +V V GW E +GV +L G++ + TDISRDGTL Sbjct: 122 CSRVVVGIDAR-----DGEVRVQGWTEGTGVDAVELALDMERRGVRRFVYTDISRDGTLE 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G NV +Y + + +SGG+ D+ L+ V VI+GRAL E +F ++ Sbjct: 177 GPNVEMYRTLGLHLKKARITASGGVSGYRDLMRLQELEPYRVDSVIIGRALYENRFPCQQ 236 Query: 238 AIACWQN 244 CW + Sbjct: 237 -FWCWHD 242 >UniRef50_B4S4Z8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Chlorobiaceae RepID=HIS4_PROA2 Length = 261 Score = 251 bits (641), Expect = 2e-65, Method: Composition-based stats. Identities = 83/241 (34%), Positives = 128/241 (53%), Gaps = 9/241 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ DG VRL +GD+ +Q+ Y ++P + Q A++LH+VDL A Sbjct: 2 LIIPAIDIKDGKCVRLTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGTMV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I+ +VA +++PVQVGGG+RS EDV L GV+RVV+GS AV + ++ F Sbjct: 62 NFEKIREIVATLDIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELLATFS 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D N + GW E+S + +L +G+K ++ TDISRDG + Sbjct: 122 PSQIVVGIDA-----ENGIPKIKGWTESSSMQDYELALEMKKLGVKRIIYTDISRDGMMQ 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G + + +SGG+ DD+ L+ GV VIVG+AL E F ++ Sbjct: 177 GVGYESTRRFAMKA-GMRVTASGGVTSSDDLKKLQTLEQYGVDSVIVGKALYESNFPCQQ 235 Query: 238 A 238 Sbjct: 236 L 236 Score = 57.5 bits (138), Expect = 4e-07, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 45/122 (36%), Gaps = 7/122 (5%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGV---SLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ A+D++ + G + + + + + K + D+ T Sbjct: 3 IIPAIDIKDGKCVR---LTRGDFDQQKIYLDNPRDMAIIWRKQNAKMLHVVDLDAALTGT 59 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 N E+ A + Q GGI +DV G GV V++G A + + E +A Sbjct: 60 MVNFEKIREIVATL-DIPVQVGGGIRSFEDVERYLGIGVSRVVIGSAAVTNPQLIAELLA 118 Query: 241 CW 242 + Sbjct: 119 TF 120 >UniRef50_A3CNT1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Bacilli RepID=HIS4_STRSV Length = 242 Score = 250 bits (640), Expect = 2e-65, Method: Composition-based stats. Identities = 79/242 (32%), Positives = 130/242 (53%), Gaps = 5/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+D+ DG VRL +GD+ ++ D L + + + G ++H+VDL GA + Sbjct: 5 ILPAIDIKDGQAVRLFKGDFSQKTVVNPDVLEQARVFKEAGVTMIHVVDLEGALEGRAAN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI + A + +QVGGG+RS E + L G+ RV++GS AVK+ + V+ ERFG+ Sbjct: 65 RDLIAQIKAETGLAIQVGGGIRSLEQIEDYLAVGIDRVIIGSMAVKNPEFVEAALERFGS 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+ +D + VA GW E S L +G++ + TD+ RDGTL G Sbjct: 125 GKIVIGIDAK-----EGLVATEGWLETSNQDYISLALAMEKIGVRLFVYTDVDRDGTLTG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N+ Y+++ A +SGGI DD+ ++ G+ G IVG+A G+ ++++ Sbjct: 180 PNIQHYQKLLASLKHAQVIASGGIQSADDLEEMKKLGLAGAIVGKAYYSGRISLEQIKEA 239 Query: 242 WQ 243 + Sbjct: 240 ER 241 >UniRef50_C0Z6P5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Bacillales RepID=HIS4_BREBN Length = 249 Score = 250 bits (640), Expect = 2e-65, Method: Composition-based stats. Identities = 94/246 (38%), Positives = 138/246 (56%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+D+ G VRL QGDYG++ Y + PL + + QGA +HLVDL GAK+ Sbjct: 4 IVYPAIDIRGGKCVRLFQGDYGQETVYADSPLAMAKRWVEQGASWVHLVDLDGAKEGKPA 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + + VPVQVGGG+R+EE +A LEAGVARV+VG+ A++ + K + G Sbjct: 64 NAAIIKEIARSIPVPVQVGGGIRTEEQIADYLEAGVARVIVGTAAIEDEPFTKRILQNDG 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + LD R N VA GW + V +L + + G + + TDI+RDGT+ Sbjct: 124 -DKIAIGLDCR-----NGLVATRGWLTTTDVQATELAKRLVTYGAETFIYTDIARDGTMT 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G NV + A + +SGG+ +DD+ L GV G IVG+AL FT++E Sbjct: 178 GPNVEEIAAL-AMATGKSVIASGGVSQLDDLLTLATHASDGVSGAIVGKALYTDAFTLEE 236 Query: 238 AIACWQ 243 A+ + Sbjct: 237 ALQRME 242 >UniRef50_Q18C71 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Firmicutes RepID=HIS4_CLOD6 Length = 240 Score = 246 bits (628), Expect = 6e-64, Method: Composition-based stats. Identities = 82/242 (33%), Positives = 140/242 (57%), Gaps = 7/242 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ D VRL QG++ K Y ++PL + +GAE +H+VDL GA+ Sbjct: 2 IIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ + +++P+QVGGGVR +E V +L+ AGV RV++GS A+++ ++V+ + Sbjct: 62 NTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+++D + + +VAV GW+ S V L + +G++ ++ TDIS+DG L Sbjct: 121 KEKIVVSIDAK-----DGKVAVRGWEVVSNVDSLTLCKQLEKIGVQTIVYTDISKDGMLQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N +YE + + +SGG+ I+DV L+ + G I+G+AL + K KEA Sbjct: 176 GPNFDIYERIAKE-TSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEAQQ 234 Query: 241 CW 242 Sbjct: 235 LC 236 Score = 49.0 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 53/123 (43%), Gaps = 7/123 (5%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGV---SLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + A+D++ ++ G + V + ++ + G +++ D++ + Sbjct: 3 IFPAIDIKDNKCVR---LTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEF 59 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N + E++ + Q GG+ D + V +L GV VI+G +E V+E + Sbjct: 60 GVNTKIIEDIANNI-DIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVN 118 Query: 241 CWQ 243 ++ Sbjct: 119 EYK 121 >UniRef50_B1I557 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_DESAP Length = 262 Score = 246 bits (628), Expect = 6e-64, Method: Composition-based stats. Identities = 86/246 (34%), Positives = 140/246 (56%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL G VRL QG ++ Y DP+ + + QGA LH+VDL GA + Sbjct: 2 LIIPAVDLRGGRCVRLFQGRADQETVYSTDPVAVARTWEEQGARRLHVVDLDGAFTGKPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ +V VN+PVQVGGG+R+ E+V LE GV RV++G+ A+ + + + +G Sbjct: 62 NSGVVLDIVKSVNIPVQVGGGIRNPENVKCYLEHGVDRVILGTAALTNPEFLDAVVAAYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+ +D R + +V V GW++ + + +E + G++ V+ TD+ RDGTL Sbjct: 122 -ERIVVGVDCR-----DGRVCVQGWEQTAATDVLPFLEELVRRGVRRVVFTDVKRDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKE 237 G N+ V A ++ +SGG+ ++D+ AL+ GV VI+G+AL G T+ E Sbjct: 176 GPNLEEIARVAAH-TELKVIASGGVSRLEDLRALKKLEHLGVDSVIIGKALYAGTITLAE 234 Query: 238 AIACWQ 243 A+A + Sbjct: 235 ALALER 240 >UniRef50_A2BQT3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Cyanobacteria RepID=HIS4_PROMS Length = 255 Score = 245 bits (626), Expect = 9e-64, Method: Composition-based stats. Identities = 80/240 (33%), Positives = 142/240 (59%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL++G VRL +GD+ K++D+ +P + + + +GA+ +H+VDL AK + Sbjct: 3 LIPAIDLMNGKCVRLFKGDFNKRKDFAKEPHEQAEFWEREGAKYIHIVDLDAAKTGSPTN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + VN+P+Q+GGG+RS+E + L GV +V++G++A++++++VK +F Sbjct: 63 DKSIKKIAKTVNIPIQIGGGIRSQERIEQLFSYGVEKVIMGTSAIENKELVKDLSNKFPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D + + +V+ GW E S + LV+ + + + TDI+ DGTL G Sbjct: 123 -RIIVGIDAK-----DGKVSTRGWLEQSNIFATDLVKEFSSFKIASFIVTDINTDGTLEG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDD---VAALRGTGVRGVIVGRALLEGKFTVKEA 238 +N + + + +SGG+G I D + +G+ GVIVG+AL E KFT+ EA Sbjct: 177 TNEEFIKSIL-EITDIPVIASGGVGSISDLLSLVKFENSGLFGVIVGKALYENKFTINEA 235 >UniRef50_D1CF74 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CF74_THET1 Length = 243 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 84/242 (34%), Positives = 148/242 (61%), Gaps = 8/242 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+++G +VRL QGDY +++ Y DP+ + + A GA+ LH+VDL GA+ Sbjct: 2 IVIPAIDILEGQLVRLTQGDYSRKKVYSYDPVVVARKWKAIGAQWLHVVDLDGARQGHPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +IK+++ VQVGGG+R+ ED+ +++E G +R+V+G++AVK + ++ ++ Sbjct: 62 NVDVIKSVIMEFGPQVQVGGGLRTLEDIQSIVELGASRIVLGTSAVKDPEFLREVCAKYP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V ALD R N VA+ GW ++SG+ + ++ + G+ ++L T I DGT+ Sbjct: 122 -DMVVAALDTR-----NGVVAIDGWTKSSGLDVLEVAKLVEDAGVGYILFTAIETDGTMT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G +++ + + + V +SGGI + +D+ L GV VIVG+AL EG+ +E I Sbjct: 176 GPDIAAVQRLMSHVS-VPVIASGGISEPEDLEELSKAGVYAVIVGKALYEGRLP-EEVIT 233 Query: 241 CW 242 + Sbjct: 234 TY 235 >UniRef50_C0QRW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Persephonella marina EX-H1 RepID=HIS4_PERMH Length = 241 Score = 244 bits (623), Expect = 2e-63, Method: Composition-based stats. Identities = 77/241 (31%), Positives = 138/241 (57%), Gaps = 10/241 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IPA+D+ DG VRL++GD YG+DP+ + + +GA+ LH+VDL GA + + Sbjct: 6 FVIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEGKPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I ++K +V V++PV+ GGG+RS E V +++E GV RVV+GS A +++ + + Sbjct: 66 NIDIVKDIVKTVSIPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVSAYP 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +++ +D + + +VA+ GW E + + + + + L TD++RDG + Sbjct: 126 G-KVIVGIDAK-----DGKVAIKGWLEKTEYTPLDFARMFDDLDIWGFLYTDVNRDGAMV 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGKFTVKE 237 G N+ + + + +SGG+G ++D+ L+ GV GV+VG+AL EGK +++ Sbjct: 180 GPNIEGTKYLAQNL-KHPVIASGGVGSVEDLKKLYDLKKYGVYGVVVGKALYEGKIKLEQ 238 Query: 238 A 238 Sbjct: 239 L 239 Score = 52.1 bits (124), Expect = 2e-05, Method: Composition-based stats. Identities = 16/119 (13%), Positives = 46/119 (38%), Gaps = 1/119 (0%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 ++ A+D++ + G + + + G KH+ D+ N Sbjct: 7 VIPAVDIKDGKAVRLYKGDPEAVTVYGDDPVSVAKQWEEKGAKHLHIVDLDGAFEGKPKN 66 Query: 184 VSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACW 242 + + +++ + + GG+ + V ++ TGV V++G + + + ++ + Sbjct: 67 IDIVKDIVKTVS-IPVEFGGGLRSFEAVKSIVETGVERVVIGSLAYQNRQEFERIVSAY 124 >UniRef50_A7H5V3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=16 Tax=Campylobacter RepID=HIS4_CAMJD Length = 244 Score = 244 bits (623), Expect = 2e-63, Method: Composition-based stats. Identities = 124/244 (50%), Positives = 174/244 (71%), Gaps = 3/244 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPALDLIDG VVRL +GDY +++ Y +PL + ++Y GA+ LHLVDLTGAKDP+KRQ Sbjct: 4 IIPALDLIDGEVVRLVKGDYKQKKVYKYNPLKKFKEYEKAGAKELHLVDLTGAKDPSKRQ 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI+ L V+V +QVGGG+RS+E+V ALL+ GV RVV+GS A+K + ++FG+ Sbjct: 64 LVLIEKLAKEVSVNLQVGGGIRSKEEVKALLDCGVKRVVIGSMAIKDATLCLEILKKFGS 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +A+VLALD + + VAV+ WQE S L ++++ Y GLKH+LCTDIS+DGT+ G Sbjct: 124 EAIVLALDT--ILKEDYVVAVNAWQEASDKKLMEVLDFYSNKGLKHILCTDISKDGTMQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV LY+ + +P++ Q+SGG+ + D+ L+G GVIVG+ALL+G F+V+E I C Sbjct: 182 VNVRLYKLIHEIFPKICIQASGGVASLKDLENLKGI-CSGVIVGKALLDGVFSVEEGIRC 240 Query: 242 WQNA 245 QNA Sbjct: 241 LQNA 244 >UniRef50_B2V6T1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Aquificales RepID=HIS4_SULSY Length = 239 Score = 243 bits (622), Expect = 3e-63, Method: Composition-based stats. Identities = 86/241 (35%), Positives = 145/241 (60%), Gaps = 10/241 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ G VVRL++G++ K + Y +P+ + + GAE +H+VDL GA + + Sbjct: 6 FIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEGLPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I +++++V VN+P++ GGG+RS E V A+L+ GV RVV+GS A ++ + E F Sbjct: 66 NIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIVESFP 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +++ +D + + +VA+ GW E + VS + + Y + + L TD+SRDG++ Sbjct: 126 -NKVIVGIDAK-----DGKVAIKGWTEKTEVSPLEFAKKYDDLDIFGFLFTDVSRDGSMI 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKE 237 G+NV E+ + +SGG+G ++DV L R G+ GV+VG+A+ EGK +KE Sbjct: 180 GANVEATVELAKNL-KHPVIASGGVGSLEDVIKLYEKREFGIFGVVVGKAIYEGKIDLKE 238 Query: 238 A 238 Sbjct: 239 I 239 Score = 51.7 bits (123), Expect = 2e-05, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 49/125 (39%), Gaps = 5/125 (4%) Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++ A+D++ + + + + + + G +H+ + DG L G Sbjct: 5 EFIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHV--VDLDGALEG 62 Query: 182 S--NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 N+ + E + R + + GG+ + V A+ GV V++G + + + Sbjct: 63 LPKNIKILESIV-RSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIV 121 Query: 240 ACWQN 244 + N Sbjct: 122 ESFPN 126 >UniRef50_Q02YX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_LACLS Length = 246 Score = 243 bits (622), Expect = 3e-63, Method: Composition-based stats. Identities = 84/237 (35%), Positives = 136/237 (57%), Gaps = 7/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL +G VRL++GDY K+ Y +PL Q + GA+ LHLVDL GAK R Sbjct: 3 IIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQTRN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLE-AGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ + N+ +++GGG+R+ + V+ LE GV RV++G+ A + D +K ++G Sbjct: 63 LEIVRKIKDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELLVKYG 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D+R V+ SGW E + + ++ +G+K V+ TDIS+DGTL Sbjct: 123 LSRIVVGVDIR-----EGFVSTSGWLEKTTLPYLSFLKDLEKIGVKTVIVTDISKDGTLT 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 G N LY+E+ + SGG+ D D+ + G+IVG+A EGK +++ Sbjct: 178 GPNFELYDEISKE-TSLDVIVSGGVKDSSDIQRAADSDFYGIIVGKAYYEGKINLEK 233 Score = 49.0 bits (116), Expect = 1e-04, Method: Composition-based stats. Identities = 22/117 (18%), Positives = 49/117 (41%), Gaps = 2/117 (1%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 ++ A+D++ E + + ++ + + +G K++ D+ N Sbjct: 3 IIPAIDLQNGEAVRLYKGDYDKKTVYSKNPLEIAQKFEQMGAKYLHLVDLDGAKLGQTRN 62 Query: 184 VSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKEAI 239 + + ++ + + GGI ++D V+ L GV VI+G A E +KE + Sbjct: 63 LEIVRKI-KDQTNLKIEIGGGIRNLDTVSLYLEQIGVERVILGTAAAEKPDFLKELL 118 >UniRef50_Q7VQW6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=117 Tax=Enterobacteriaceae RepID=HIS4_BLOFL Length = 251 Score = 242 bits (619), Expect = 7e-63, Method: Composition-based stats. Identities = 123/248 (49%), Positives = 175/248 (70%), Gaps = 4/248 (1%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALD+I+G VRL+QG Y Q YG +P L Y QGA ++HLVDL GA++P R Sbjct: 1 MIIPALDIINGDAVRLYQGKYQSQSHYG-NPYSILSTYVQQGATMIHLVDLDGARNPKNR 59 Query: 61 QIPLIKTL---VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 Q+ LIK L ++ +Q+GGG+R D+ LL+ GV RV++GS A+ VK WF Sbjct: 60 QLSLIKELTHTAITSHLKIQIGGGIRHATDIKTLLKFGVNRVILGSIAITHPKKVKQWFT 119 Query: 118 RFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 F +LVLALD+ ID + N++V + GWQ+ + + LE+++E Y VGLKHVLCTDIS+DG Sbjct: 120 YFNPSSLVLALDIYIDSKNNRKVVIHGWQKETNIQLEEVIENYNSVGLKHVLCTDISKDG 179 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 TL GSN++LY+ +C ++P+++FQ+SGG+ + ++ LR +GV +I+GR+ LE KFT+ E Sbjct: 180 TLLGSNINLYQSICYKWPKISFQASGGVAKLTEILQLRSSGVNSIIIGRSFLEKKFTLTE 239 Query: 238 AIACWQNA 245 AI+CWQNA Sbjct: 240 AISCWQNA 247 >UniRef50_Q8DMA5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=23 Tax=Bacteria RepID=HIS4_THEEB Length = 257 Score = 242 bits (618), Expect = 8e-63, Method: Composition-based stats. Identities = 86/243 (35%), Positives = 128/243 (52%), Gaps = 10/243 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL+DG VRL QG+Y K + +DPL + GA LHLVDL AK R Sbjct: 3 VIPAIDLLDGKCVRLVQGNYDKVNVFHDDPLKVALYWQRLGAPRLHLVDLDAAKTGEPRN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI +VA + +PVQVGGG+RS + VA L GV R ++G+ A+++ +V + Sbjct: 63 YDLIGKIVASLEIPVQVGGGLRSRQAVADLFLQGVNRAILGTVALENPKLVASLAAEYPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LD R + VA GW E S + L + +G+ + TDI RDGTL G Sbjct: 123 -RIWVGLDAR-----DGYVATRGWLETSKILATDLAQNMAAMGVAGFVYTDIQRDGTLQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKEA 238 N+ ++ A +SGG+ ++D+ +L G+ G IVG+AL ++EA Sbjct: 177 PNIPALRQLLA-VTNRPVIASGGVSSLNDILSLFALTPHGLVGAIVGKALYTKAMDLREA 235 Query: 239 IAC 241 + Sbjct: 236 VRA 238 >UniRef50_Q88UE2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillus RepID=HIS4_LACPL Length = 241 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 87/238 (36%), Positives = 133/238 (55%), Gaps = 5/238 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI PA+DL G VRL+QGD+ + DP+ + Q A G + LH+VDL GAK Sbjct: 3 MIFPAIDLRAGQSVRLYQGDFKQATLINPDPVVQAQQINAAGLQQLHMVDLDGAKSGRPE 62 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I + +++GGG+R+ E LE G+ R+++GS A+ +VK FG Sbjct: 63 NFATITAIRQAFTGTIELGGGIRTYELATRYLELGIDRLILGSVALTDPRLVKRLLSEFG 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+ LD N VA+ GW E S + L++T G KH + TD++RDGT+ Sbjct: 123 GERIVIGLD-----GTNGYVAIKGWLEQSQTKMSTLMKTMTTSGAKHFIVTDVARDGTMQ 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N++LY+E+ A+ P +SGG+ ++ DV L+ +G + VI+G+AL EG T+ E Sbjct: 178 GPNLALYQELQAQVPTANLIASGGVRNLTDVQVLQASGFKDVIIGKALAEGGVTLAEL 235 >UniRef50_A8S9L9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Faecalibacterium prausnitzii M21/2 RepID=A8S9L9_9FIRM Length = 239 Score = 240 bits (613), Expect = 3e-62, Method: Composition-based stats. Identities = 82/243 (33%), Positives = 127/243 (52%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL G VVRL QGDY + YG DP + + + A GA+ LH+VDL GAKD Sbjct: 3 LFPAIDLRGGQVVRLTQGDYDRMTVYGQDPCAQARSFVAAGAKNLHVVDLDGAKDGTLSN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I L + ++VGGG+R+EE + L GV R ++GS AV +++G Sbjct: 63 YDTIAALAKQGGLYIEVGGGIRTEERIEKYLSLGVGRCILGSVAVTDFAFTARMLQKYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D + + VA+ GW+E S + G ++ TDI+ DG + G Sbjct: 122 DKIAVGVDAK-----DGYVAIHGWKEVSAEPGVAFCKRLAEAGCTAIIYTDIACDGAMQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +N+SLY ++ A P VAF +SGGI ++ L+ G I+G++L G + + Sbjct: 177 TNLSLYRQLAAEVPGVAFTASGGISSEAELLELQQMGTAAAILGKSLYTGALDLARCVQL 236 Query: 242 WQN 244 Q+ Sbjct: 237 VQD 239 >UniRef50_B5YIB4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_THEYD Length = 244 Score = 240 bits (613), Expect = 3e-62, Method: Composition-based stats. Identities = 87/243 (35%), Positives = 133/243 (54%), Gaps = 8/243 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL DG VRL QG + + Y ++P + +GAEVLH+VDL GAK+ Sbjct: 3 IIPAIDLKDGKCVRLRQGKFSEVTVYYDNPEDAALRWQNEGAEVLHVVDLDGAKEGKIGN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P IK + ++VGGG+R ED+ LL G+ RV+VG+ AV+S D VK +RF Sbjct: 63 LPSIKKIREAFRGNIEVGGGIRRIEDIELLLSVGIDRVIVGTIAVQSPDFVKEVCKRFP- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D + + VAV GW E + + +L G+ ++ TDISRDG L G Sbjct: 122 KKIIVGIDAK-----DGLVAVKGWVEVTEIRAIELALKMQDYGIWGIIYTDISRDGMLTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 N+ + + +V +SGG+ I+D+ L + GVI G+A+ G +KEA+ Sbjct: 177 PNIEATKALV-ESVKVPVIASGGVSSIEDIRKLAEIPQLWGVITGKAIYSGAIDLKEALR 235 Query: 241 CWQ 243 + Sbjct: 236 IIK 238 >UniRef50_C7PAV4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=C7PAV4_CHIPD Length = 389 Score = 239 bits (611), Expect = 5e-62, Method: Composition-based stats. Identities = 92/237 (38%), Positives = 147/237 (62%), Gaps = 5/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+IDG VRL QGDY +++ Y PL + + + G LHLVDL GAK A Sbjct: 148 VIPAIDIIDGKCVRLTQGDYAQKKVYNEHPLEVAKAFESIGIRRLHLVDLDGAKKGAVVN 207 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + N+ + GGG+++E+D+ + E G A +GS AVK + GW +++GA Sbjct: 208 WKVLEAIAGKTNLVIDFGGGIKTEDDLRIVYENGAALATIGSIAVKDPALFSGWVKKYGA 267 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + L DV+ +++AV GW E + +S+ +E + G++H+ CTDI++DG L G Sbjct: 268 DKIFLGADVK-----EEKIAVGGWLETTELSVFDFLEENVKQGVQHIFCTDIAKDGLLQG 322 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 +V+LYE++ R+PQ+ F +SGG+ + DV AL G GVIVG+A+ E + ++KE Sbjct: 323 PSVALYEKILQRFPQIDFVASGGVSTMADVHALAEAGCSGVIVGKAIYEERISMKEL 379 >UniRef50_Q65EG2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Bacillales RepID=HIS4_BACLD Length = 245 Score = 239 bits (611), Expect = 5e-62, Method: Composition-based stats. Identities = 92/242 (38%), Positives = 137/242 (56%), Gaps = 10/242 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G VRL QGDY K+ YG+ PL +A +GA +HLVDL GA++ K Sbjct: 6 VYPAIDIRNGKCVRLIQGDYEKETIYGHSPLEMASRFAEEGASWIHLVDLDGAREGKKVN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ ++V VQVGGG+R+E+DV L GV RV++GS+AV + + VK + +G Sbjct: 66 GGHVISIADKLDVKVQVGGGIRTEKDVYDYLSQGVERVILGSSAVSNTEFVKKMLKAYGG 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LD R + V+ GW E S V E+L G + + TDI+ DG L+G Sbjct: 126 H-IAIGLDAR-----DGFVSTEGWLETSSVRAEELGRELANEGAEVFIFTDIATDGMLSG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKEA 238 N++ E+ AR +SGG+ + D+ AL GV G IVG+AL +FTV EA Sbjct: 180 PNINSTVEL-ARATGKQVIASGGVSSLADLEALASRASEGVSGAIVGKALYTNQFTVAEA 238 Query: 239 IA 240 + Sbjct: 239 LE 240 >UniRef50_Q12NS9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Gammaproteobacteria RepID=HIS4_SHEDO Length = 250 Score = 239 bits (611), Expect = 5e-62, Method: Composition-based stats. Identities = 142/250 (56%), Positives = 182/250 (72%), Gaps = 5/250 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPA+DLIDG VVRL+QGDY KQ + PL +L+ Y QGA++LH+VDLTGAKDP +R Sbjct: 1 MIIPAIDLIDGQVVRLYQGDYDKQTTFDLSPLAQLKSYQDQGAKLLHIVDLTGAKDPNQR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 QI LI LVAG++V +QVGGG+RSE+ V LL GV RVV+GS AVK ++VK W ++G Sbjct: 61 QIKLISELVAGLDVDIQVGGGIRSEQQVTELLAIGVKRVVIGSLAVKEPELVKSWLNKYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVG-----LKHVLCTDISR 175 +DA+ LALDV I+ G K VAVSGWQ G +LE LV + G LKH L TDISR Sbjct: 121 SDAICLALDVNINANGEKIVAVSGWQSAGGKTLESLVAEFERPGSKQTALKHALVTDISR 180 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGTL G+N +LY E+ A YP + +Q+SGGI +DDV+A++ + G+I+G+ALL +FTV Sbjct: 181 DGTLTGANTALYTELAAAYPTILWQASGGIATLDDVSAVKDSKAAGIIIGKALLINQFTV 240 Query: 236 KEAIACWQNA 245 +EAI CW NA Sbjct: 241 EEAIQCWPNA 250 >UniRef50_A4G9I7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=209 Tax=Bacteria RepID=HIS4_HERAR Length = 265 Score = 239 bits (611), Expect = 6e-62, Method: Composition-based stats. Identities = 78/251 (31%), Positives = 130/251 (51%), Gaps = 20/251 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL DG VRL QGD + + DP + + QGA LHLVDL GA + Sbjct: 2 LLIPAIDLKDGHCVRLKQGDMDQATVFSEDPADMARHWLEQGARRLHLVDLNGAFAGKPK 61 Query: 61 QIPLIKTLVAGV----------NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 P +K ++ V +PVQ+GGG+R + + L+ G++ +++G+ AVK+ Sbjct: 62 NEPAVKAILQAVREYAEKNGIEEIPVQLGGGIRDLDTIERYLDDGLSYIIIGTAAVKNPG 121 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 + F +++ LD + + +VA GW + SG + L + + G + ++ Sbjct: 122 FLHDACSAFPGQ-IIVGLDAK-----DGKVATDGWSKLSGHEVIDLAKKFEDYGCESIIY 175 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRA 227 TDI RDG + G N+ ++ + +SGG+ +I DV AL + G+ GVI GR+ Sbjct: 176 TDIGRDGMMGGVNIEATVKLAQSMT-IPVIASGGVHNIKDVEALCAVQEEGIEGVICGRS 234 Query: 228 LLEGKFTVKEA 238 + EG ++ A Sbjct: 235 IYEGTLDLRSA 245 >UniRef50_C9KKW6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW6_9FIRM Length = 252 Score = 239 bits (610), Expect = 7e-62, Method: Composition-based stats. Identities = 70/244 (28%), Positives = 122/244 (50%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ RD G DP+ Y + A+ L +D+T + D Sbjct: 6 IIPCLDVKDGRVVKGT--NFVGLRDAG-DPVELAARYDEERADELVFLDITASSDNRGTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + + + V +P VGGG+R+ ED+ +L+AG + + + AVK+ ++K E+FG Sbjct: 63 VNVARDCASKVFIPFTVGGGIRTVEDMRRMLKAGADKTSLNTAAVKNPGLLKEGAEKFGR 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +VLA+D R +V V+G + +G+ + V+ + +G +L T + DGT G Sbjct: 123 QCMVLAVDARRAGNHRWEVYVNGGRTPTGLDCLEWVKKAVALGAGEILLTSMDADGTKDG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 ++ L V + V +SGG G ++ + G V+ G+FTV++ Sbjct: 183 YDIELTRAV-SDAVNVPVIASGGAGKLEHFYDVLTLGHADAVLAASVFHYGQFTVRQVKE 241 Query: 241 CWQN 244 Q+ Sbjct: 242 YLQS 245 Score = 41.3 bits (96), Expect = 0.031, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 33/99 (33%) Query: 25 RDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRS 84 G D L ++ A GA + L + I L + + VNVPV GG Sbjct: 148 TPTGLDCLEWVKKAVALGAGEILLTSMDADGTKDGYDIELTRAVSDAVNVPVIASGGAGK 207 Query: 85 EEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADA 123 E +L G A V+ ++ + + Sbjct: 208 LEHFYDVLTLGHADAVLAASVFHYGQFTVRQVKEYLQSR 246 >UniRef50_Q12WC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=18 Tax=Euryarchaeota RepID=HIS4_METBU Length = 246 Score = 238 bits (609), Expect = 9e-62, Method: Composition-based stats. Identities = 81/246 (32%), Positives = 139/246 (56%), Gaps = 9/246 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ G V+L QG G + +DP+ D+ +QGA LHL+DL GA + + Sbjct: 5 VIPAVDMKGGKCVQLVQGVPGSEMISLDDPVEVALDWVSQGARTLHLIDLDGAIEGNRTN 64 Query: 62 IPLIKTLVAGV---NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 P+IK +V + +QVGGG+RS ED A LL+ G+ +V++ + A+K +++K + Sbjct: 65 APIIKKIVEKCKPQGIYIQVGGGIRSFEDAATLLDIGIDKVILSTAALKDPELIKKLSDE 124 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 FG++ + +ALD + N ++++ GW + S + ++ + G +L T+I +G Sbjct: 125 FGSEHINVALDSK-----NGKISIEGWTKESEHTAVEMGSQFEEKGAGSILFTNIDSEGL 179 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 L G N EE+ + +SGG+ ++D+ L+ TG GV+VG AL + +FT+ EA Sbjct: 180 LNGVNPKPTEELV-NAVTIPVIASGGVTTLEDIVTLKNTGAAGVVVGSALYKKRFTLTEA 238 Query: 239 IACWQN 244 I + Sbjct: 239 INIISD 244 >UniRef50_Q058A3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola str. Cc (Cinara cedri) RepID=HIS4_BUCCC Length = 245 Score = 238 bits (609), Expect = 1e-61, Method: Composition-based stats. Identities = 103/242 (42%), Positives = 157/242 (64%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP+LD I G +VRL+QG+Y + Y D +++ Y QGA +HLVDL G +P R Sbjct: 1 MIIPSLDFIHGKIVRLYQGNYNNKISYKKDIFKQIEKYIYQGATYIHLVDLDGCNNPENR 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q + NV QVGGG+RS+ D+ L AGV+++V+G++A+ + K W + +G Sbjct: 61 QKSMFNIFSNFKNVSFQVGGGIRSKRDIENLFHAGVSKIVIGTSAILYPNKFKKWLKNYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + VL++D+ I+ + ++A+ GW++ + ++L+ ++ ++P GLK++LCTDISRDGT + Sbjct: 121 SKNFVLSVDININTKKENKIAIQGWKKTTEINLDDAIKQFIPYGLKNILCTDISRDGTFS 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+SLY+ + ++P + QSSGGI I D+ L+ V VIVGRALLE KFT EA Sbjct: 181 GPNISLYKYLKNKFPNIVLQSSGGINSISDIYNLKKNNVEHVIVGRALLENKFTFLEASK 240 Query: 241 CW 242 CW Sbjct: 241 CW 242 >UniRef50_Q1R079 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=31 Tax=cellular organisms RepID=HIS4_CHRSD Length = 249 Score = 238 bits (609), Expect = 1e-61, Method: Composition-based stats. Identities = 87/246 (35%), Positives = 129/246 (52%), Gaps = 11/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL DG VRL QG YG+DP+ + GA LHLVDL GA + Sbjct: 2 LVIPAIDLKDGQCVRLKQGRMDDSTTYGDDPVAMAARWVETGARRLHLVDLNGAFEGKPV 61 Query: 61 QIPLIKTLVAG-VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + ++P+Q+GGG+R+ E + A LEAGV+ V++G+ AVK V RF Sbjct: 62 NAEAVTAIARAYPDLPIQIGGGIRTAETIEAYLEAGVSYVIIGTQAVKEPAFVGEMCRRF 121 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 +++ LD R + VA GW E S + L + + G+ ++ TDI+RDG + Sbjct: 122 PGH-VIVGLDAR-----DGYVATDGWAEVSTLKAVDLAKRFADDGVSSIVYTDIARDGMM 175 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVK 236 G N++ E+ AR + +SGG+ + D+ AL G+ G I GRA+ EGK V Sbjct: 176 QGVNIAATAEL-AREGGLPVIASGGVTHLGDIEALLEVADAGILGAITGRAIYEGKLDVA 234 Query: 237 EAIACW 242 EA Sbjct: 235 EAQRLC 240 >UniRef50_B8FP23 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_DESHD Length = 250 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 87/245 (35%), Positives = 136/245 (55%), Gaps = 12/245 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL +G VRL QG YG P+ + + QGA+ LH+VDL GA Sbjct: 5 LFPAIDLKEGKAVRLLQGRMEDATVYGEQPVEVARKFKEQGADSLHVVDLDGAFAGKPVN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I L+ + VQVGGG+R+ E + LL+ GV RV++G+ AV++ ++V+ +RF Sbjct: 65 DAVILKLIQSSGLRVQVGGGIRTLERIEELLKLGVERVILGTVAVRNPELVEKAVQRF-E 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +A+V+ +D + + VAV GW E + + L VG+KH++ TDISRDG L G Sbjct: 124 EAVVIGIDAK-----DGLVAVQGWAEKTEIKALDLALRMKKVGVKHLVFTDISRDGMLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG-----TGVRGVIVGRALLEGKFTVK 236 N+ E+ AR + +SGG+ ++D+ L+ + G IVG+AL G F++ Sbjct: 179 PNIQSTVEL-ARLSGLQVVASGGVSRLEDLRLLQEEANRGVSLEGAIVGKALYAGAFSLA 237 Query: 237 EAIAC 241 EA+ Sbjct: 238 EALRV 242 >UniRef50_Q7UG70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rhodopirellula baltica RepID=HIS4_RHOBA Length = 253 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 80/246 (32%), Positives = 124/246 (50%), Gaps = 10/246 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK-R 60 I PA+DL G VRL QGDY +Q +G+DP+ + + GA+ LHLVDL A+ + Sbjct: 14 IWPAIDLRHGKPVRLRQGDYDQQTTFGDDPVEFAKRWQESGAKRLHLVDLDAARGDSPDA 73 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ ++ +P Q+GGGVR E + +LL GV R+VVGS A+K D +++ Sbjct: 74 NRDAVQRIIEATGLPCQMGGGVRDEITIESLLNVGVTRLVVGSRALKDPDWFVEMCDKYP 133 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPV--GLKHVLCTDISRDGT 178 LV +D R + +VA GW E S VS + + ++ TDI++DG Sbjct: 134 G-KLVAGIDAR-----DGKVATQGWLETSDVSAFEFATKLRSRTENIAAIVYTDIAKDGM 187 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 + G N E+ A + +SGG+ DD+ L + IVGR+L +G + E Sbjct: 188 MQGPNFEGLAEMAA-ASDIPLVASGGVTTYDDIKQLVEMKMPAAIVGRSLYDGVMELGEV 246 Query: 239 IACWQN 244 + + Sbjct: 247 VRLAGD 252 >UniRef50_B3DY29 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3DY29_METI4 Length = 248 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 87/242 (35%), Positives = 133/242 (54%), Gaps = 7/242 (2%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQI 62 A+DL G VVRL QG + YG+DP+ + +QGA+ LH+VDL GA R + Sbjct: 12 YAAIDLFKGQVVRLRQGKLEEMTVYGSDPVKTALFWQSQGADGLHIVDLEGAFSGTPRHL 71 Query: 63 PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGAD 122 L++ + V +P+Q GGG+R+ E V LE G RVV+GS V ++ E+ G + Sbjct: 72 DLLEKIAYAVTIPIQFGGGLRTVEQVLKALEGGAQRVVIGSKLVTDPGFLQELSEKIGPE 131 Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 +V ALD N ++ + GW+++SG SLE ++ G +L T+I DGTL G+ Sbjct: 132 KIVAALDT-----QNGEIQIEGWKKSSGYSLENFIKWVEQKGAGFLLYTNIQTDGTLKGA 186 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIAC 241 +V ++V ++ +SGGIG DV L G+ G I+GR+L EGK ++ E Sbjct: 187 DVRGTQKVV-EMSRLPVFASGGIGCTKDVEELLKLKGLYGAILGRSLYEGKISLSEIKKN 245 Query: 242 WQ 243 ++ Sbjct: 246 FK 247 >UniRef50_P59520 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Buchnera aphidicola (Baizongia pistaciae) RepID=HIS4_BUCBP Length = 241 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 112/241 (46%), Positives = 161/241 (66%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP++DLI+G +VRL+QG+Y + Y N+ Y QGA+++HLVDL GA P + Sbjct: 1 MIIPSIDLIEGNIVRLYQGNYDTKTFYQNNIYDIALKYYNQGAKIVHLVDLDGALCPNNK 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LIK L+ N +QVGGG+RS +DV LL G RVV+GS+A+ + V+ W FG Sbjct: 61 QTSLIKNLLNYFNFHIQVGGGIRSYKDVETLLLNGAKRVVIGSSAINNITEVEKWLLEFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++VLALDV + G K+V ++GW+ S VSLE ++E + +G+K+VLCTD+ +DGT Sbjct: 121 YKSIVLALDVYVRNNGYKEVVINGWKNRSNVSLESVLERFSTLGIKYVLCTDVKKDGTCL 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N +LY+ + + V FQ SGGIG I DV + + +G++ +I+GRALLE KF++ EAI Sbjct: 181 GPNFTLYKNISKLFKNVCFQLSGGIGTISDVISAKKSGIKDIIIGRALLENKFSLLEAIR 240 Query: 241 C 241 C Sbjct: 241 C 241 >UniRef50_A4XL21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CALS8 Length = 237 Score = 237 bits (605), Expect = 3e-61, Method: Composition-based stats. Identities = 82/239 (34%), Positives = 136/239 (56%), Gaps = 6/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+IDG VRL QGDY + ++Y DP+ + + + +GA LH+VDL GAK + Sbjct: 2 IVIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + ++ V+ GGG+R ++ + L AG+ +++GS K+ + V+ +RFG Sbjct: 62 NFEVIKRIKESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +LD V +SGWQE + +S+E+ + +G + ++ TDI DG L Sbjct: 122 NERFIASLDF-----EEGYVKLSGWQEATRISVEEGILHIKKLGFQKLIYTDIKTDGMLK 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N + + + + SSGGI ++DV L+ GV GVI+G+AL G + E I Sbjct: 177 GHNFEAAKYIRSLFDGF-LISSGGISSMNDVLKLKDIGVDGVIIGKALYTGHVKLNEII 234 Score = 43.6 bits (102), Expect = 0.006, Method: Composition-based stats. Identities = 15/121 (12%), Positives = 45/121 (37%), Gaps = 1/121 (0%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 ++ A+D+ + + + Q + + G +++ D+ + N Sbjct: 3 VIPAIDIIDGKCVRLTQGDYSRVQEYNLDPVQQAKYFEKEGARYLHVVDLDGAKKGSPVN 62 Query: 184 VSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQ 243 + + + ++ + GGI D + G+ +I+G + + V++ + + Sbjct: 63 FEVIKRI-KESTSLSVECGGGIRDKKTINDYLLAGIDYIILGSVIFKNPEFVEDVLKRFG 121 Query: 244 N 244 N Sbjct: 122 N 122 >UniRef50_A0M284 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=35 Tax=cellular organisms RepID=HIS4_GRAFK Length = 241 Score = 237 bits (605), Expect = 3e-61, Method: Composition-based stats. Identities = 85/243 (34%), Positives = 146/243 (60%), Gaps = 5/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D+I+G VRL +GDY ++ Y DPL + + A G E LHLVDL GAK Sbjct: 3 IIPAIDIIEGKCVRLSKGDYATKKIYNEDPLEVAKSFEAHGIEYLHLVDLDGAKSSHIVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++T+ ++ + GGG+++++D+ E+G +++ GS AVK+ D+ + W ++FG Sbjct: 63 HKILETIANKTSLKIDFGGGLKTDKDLQIAFESGASQITGGSIAVKNSDVFQNWIQKFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++L D + ++++AVSGW E+S + ++ Y G+K+V+CTDIS+DG L G Sbjct: 123 KKIILGADAK-----DRKIAVSGWLEDSNEEIIPFIQNYEEKGVKYVICTDISKDGMLEG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + LY+E+ + + +SGGI + D++ L G GVI+G+A+ E + ++K+ Sbjct: 178 PSFELYKEILSETKNINLIASGGISEFDELPKLAELGCEGVIIGKAIYENRISLKQFENY 237 Query: 242 WQN 244 N Sbjct: 238 ILN 240 >UniRef50_B0K628 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Thermoanaerobacter RepID=HIS4_THEPX Length = 235 Score = 236 bits (604), Expect = 3e-61, Method: Composition-based stats. Identities = 77/242 (31%), Positives = 132/242 (54%), Gaps = 8/242 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+++ VRL +GD+ + Y +P+ + + GA+ +H+VDL GAK Sbjct: 2 VLIPAIDIMEEKCVRLTKGDFNTKEVYYENPVDVAKMWEELGAKRIHVVDLDGAKQGHLV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ ++ ++VGGG+R+ E + L GV V++GS A+ +D++ +G Sbjct: 62 NGNIIEQIIKSCKAEIEVGGGIRNRETIDYLFSVGVKYVILGSAAIYDKDLLLYSLSNYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++ +D + N +VAVSGW E + + +L + +G+K ++ TDIS+DGTL Sbjct: 122 -ERTIVGIDSK-----NGEVAVSGWLEKTKIKDMELAKKMKEIGVKTIIFTDISKDGTLN 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N E + V +SGGI I+D+ L+ G G I+G+AL GK K A+ Sbjct: 176 GPNFKALENILK--TGVQVIASGGISSIEDLKKLKEMGAYGAIIGKALYIGKINFKSALE 233 Query: 241 CW 242 Sbjct: 234 VI 235 >UniRef50_D1BQK4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Firmicutes RepID=D1BQK4_VEIPT Length = 240 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 85/243 (34%), Positives = 136/243 (55%), Gaps = 5/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI PA+DL DG VRL++GD+ ++ DP+ + + Y A LHLVDL GAK Sbjct: 1 MIFPAIDLQDGRSVRLYKGDFAQETVINPDPVDQAKQYEAAKVGALHLVDLDGAKAGKPV 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++K + A +++GGG+R +E V L GV RV++GS A+K+ + K +G Sbjct: 61 NVDIVKAVRAAFTGILEIGGGIRDKEAVDLYLSLGVDRVILGSVALKNPKLTKQVIAEYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ +V+ +D + N +VA GW + S V + L+ + G K+ + TD+ RDGT+ Sbjct: 121 AEHIVIGVDGK-----NGKVAAEGWLDQSDVPMTDLIGAMIEGGAKYFIVTDVDRDGTMQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+N L + +P +SGG+ +++D+ +L GV IVG+AL EG T++E Sbjct: 176 GANEELLGNLQKEFPTARIVASGGVRNLEDIKSLEQKGVMDSIVGKALYEGTITLEEIGE 235 Query: 241 CWQ 243 Q Sbjct: 236 YNQ 238 >UniRef50_A3EUM5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Leptospirillum RepID=A3EUM5_9BACT Length = 247 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 82/241 (34%), Positives = 137/241 (56%), Gaps = 7/241 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G VVRL QG + ++ YG DP+ + +G + LH+VDL GA++ Sbjct: 3 LYPAIDIRNGKVVRLTQGRFDQETVYGEDPVRTALQFRERGVQHLHVVDLDGAREGVPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ +V VQVGGGVRS++ + +AGV+R+++G+ A+K + E+ Sbjct: 63 RSLIREIVKAFRGFVQVGGGVRSKDIASFYYDAGVSRLILGTAAIKDPVFLGSMIEQHP- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + +DV+ ++ +AV+GW + +++ +G++ + TDI RDG L+G Sbjct: 122 DLFYVGIDVK-----DESLAVNGWLDLDTQDPLEVMVRMSELGVRGFVYTDIHRDGLLSG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + YE + R +V +SGG+ DI D+A LR GV G IVG+A+ G+ + EA+ Sbjct: 177 PNFARYETLR-RTVRVPVIASGGVRDISDIARLREIGVDGAIVGKAIYTGEMDLTEALRL 235 Query: 242 W 242 Sbjct: 236 L 236 Score = 51.3 bits (122), Expect = 3e-05, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 33/93 (35%) Query: 28 GNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEED 87 DPL + + G D+ + +TL V VPV GGVR D Sbjct: 145 TQDPLEVMVRMSELGVRGFVYTDIHRDGLLSGPNFARYETLRRTVRVPVIASGGVRDISD 204 Query: 88 VAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +A L E GV +VG + + G Sbjct: 205 IARLREIGVDGAIVGKAIYTGEMDLTEALRLLG 237 >UniRef50_C2BYH3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Listeria grayi DSM 20601 RepID=C2BYH3_LISGR Length = 240 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 87/244 (35%), Positives = 129/244 (52%), Gaps = 7/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G VRL+QGD+ K+ DP+ + +AA GA LH+VDL GA Sbjct: 3 IFPAIDIKNGKCVRLYQGDFAKETMMNADPIDQAAKFAAAGATFLHIVDLDGAVSGKPTN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I LI+ L V +P+QVGGG+R+ V L AG RV++GS A+ D VK ++G Sbjct: 63 IALIQRLQQQVKIPIQVGGGIRTMTQVDTYLRAGAERVIIGSAALSDPDFVKAAVTKYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D +++ +D + N VA GW + S +G+ ++ TDIS+DGTLAG Sbjct: 122 DKIIIGIDAK-----NGFVATEGWLQLSDKKATTFAGEIAKLGVNTIIYTDISKDGTLAG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + ++A +SGG+ D+ L G G I G+AL EGK T+ + + Sbjct: 177 PNFEELRAIQKSA-RIAVIASGGVSSKADLEQLAAEGFYGAIAGKALYEGKITMADVLEV 235 Query: 242 WQNA 245 +A Sbjct: 236 EGHA 239 >UniRef50_Q0AW40 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Clostridia RepID=HIS4_SYNWW Length = 244 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 85/247 (34%), Positives = 135/247 (54%), Gaps = 9/247 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL QG + Y + P + + QGA LH+VDL GA + + Sbjct: 2 IIYPAIDLKDGQCVRLVQGRVENKTVYSDAPANVARSFQEQGASFLHIVDLDGAFQGSPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I+ + A +++ QVGGG+R DV LL G +RV++G+ AV D + ++FG Sbjct: 62 NLKAIEAIAAAIDISFQVGGGLRQLSDVEKLLALGASRVIIGTRAVSHPDFIANLLDKFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VL LD + VAV GW S VS +G++ + TD+SRDG L Sbjct: 122 PERIVLGLDAK-----EGMVAVEGWVSTSSVSAIDFGLQMKALGIQTAIYTDVSRDGLLQ 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N++ +E+ A + +SGG+ +D++ AL+ GV G I+G+AL +GK + + Sbjct: 177 GPNLAAIKEM-ASSTGLDIIASGGVSSLDNIRALKELENDGVSGAIIGKALYDGKIGLVD 235 Query: 238 AIACWQN 244 A+ ++ Sbjct: 236 ALREAES 242 >UniRef50_A6LDI6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=24 Tax=Bacteroidetes RepID=HIS4_PARD8 Length = 239 Score = 236 bits (603), Expect = 5e-61, Method: Composition-based stats. Identities = 82/239 (34%), Positives = 136/239 (56%), Gaps = 5/239 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+IDG VRL QGDY ++ Y DPL + + G LH+VDL GA++ Sbjct: 4 LIPAIDIIDGKCVRLTQGDYATKKVYNEDPLEVAKMFEGNGIRRLHVVDLDGAREGRIIN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + ++ + GGG++ E+D+ E+G V GS AVK+ +M W +FG+ Sbjct: 64 YRILERIATRTSLIIDFGGGLKQEDDLEIAFESGAQMVTGGSIAVKNPEMFTSWISKFGS 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++L D + ++A+SGW+E + L ++ Y G+ V+CTDI+RDG L G Sbjct: 124 EKIILGADAKEK-----KIAISGWEETTSQELVPFIKGYYDKGITKVICTDIARDGMLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 + LY+E+ P + +SGG+ I+D+ L G+ VI G+A+ EGK +K+ + Sbjct: 179 PAIDLYKEIRDEIPFLYIIASGGVSSIEDIEKLSEAGIPAVIFGKAIYEGKIQLKDLLR 237 >UniRef50_B3QRR1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Chlorobiaceae RepID=HIS4_CHLT3 Length = 262 Score = 235 bits (599), Expect = 1e-60, Method: Composition-based stats. Identities = 78/248 (31%), Positives = 135/248 (54%), Gaps = 9/248 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ G VRL +GD+ +++ Y ++P + Q A+++H+VDL A Sbjct: 2 LIIPAIDIKGGKCVRLTRGDFEQEKIYLDEPSDMAIIWRKQNAKLIHVVDLDAALTGKPE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 IK +V +++P+++GGG+R+ ED A L+ GV RVV+GS AVK+ +V E++G Sbjct: 62 NFDKIKQIVDTLDIPIEIGGGIRTAEDAARYLDIGVYRVVIGSAAVKNPSLVSQLIEKYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+ +D + +SGW E+S +L G++ ++ TDI+RDGTL Sbjct: 122 PRKIVVGIDA-----EDGIAKISGWTESSQKKDYELALEMKDRGVERIIYTDITRDGTLE 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA---ALRGTGVRGVIVGRALLEGKFTVKE 237 G + + Q+ +SGG+ D++ L GV VI+G+AL E +F ++ Sbjct: 177 GVGYETTKAFAEKA-QMRITASGGVFGKQDLSKLCKLEHLGVDSVIIGKALYEERFPCQK 235 Query: 238 AIACWQNA 245 ++ + Sbjct: 236 LWHLFEES 243 >UniRef50_C9KKW7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KKW7_9FIRM Length = 243 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 91/245 (37%), Positives = 143/245 (58%), Gaps = 10/245 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ G VRL +GD+ K+ + + P + + QGA+ LHLVDL GA + Sbjct: 2 IIFPAIDIRGGKCVRLLKGDFAKETVFSDKPEEMAKKWQTQGAQFLHLVDLDGALAGRPQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +K ++A V++PV++GGG+R+ E + +L GV RV++GS AV+ ++VK ++G Sbjct: 62 NLATVKAILAAVDIPVELGGGIRTLESIDEVLALGVRRVILGSVAVRDPELVKTACAKYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V+ +D + + VAV GW + V L + G+K ++ TDISRDGTLA Sbjct: 122 -DRIVVGIDAK-----DGIVAVDGWGVSGDVEATALAKEMKKAGVKTIIYTDISRDGTLA 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR---GTGVRGVIVGRALLEGKFTVKE 237 G NV ++ AR VA +SGG+ I D+ AL+ G+ GVIVG+++ G + E Sbjct: 176 GVNVEATAKL-ARESGVAVVASGGVKSIADIEALKPYEKAGIEGVIVGKSIYMGTLDLAE 234 Query: 238 AIACW 242 AI Sbjct: 235 AIEIA 239 >UniRef50_Q3AD49 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Clostridia RepID=HIS4_CARHZ Length = 243 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 80/246 (32%), Positives = 133/246 (54%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL+ VVRL QG+ ++ +Y P+ Y GA ++H+VDL A Sbjct: 2 ILIPAIDLMGKKVVRLTQGEKERKTEYPISPVELALKYQEAGARLIHVVDLDRAFTGESE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I ++ V++PVQVGGG+R E L++ GV+RV+VG+ AV + ++++ Sbjct: 62 NFEVIAEIIKNVSIPVQVGGGIRDIESFRELIDLGVSRVIVGTIAVTNPELLEEML-TLD 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + +D + N VA+ GW E+S L +G+ ++ TDI+RDG+L Sbjct: 121 RDKVAVGIDAK-----NGWVAIKGWVESSNYRALDLAYKVKEMGVTTIIYTDIARDGSLT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKFTVKE 237 G N + ++ + +SGGI ++D+ R G + GVI G+A+LEGK +KE Sbjct: 176 GPNFNETLKLAID-TGLKVIASGGISGLEDLRRWRELGENKIYGVIAGKAILEGKIDLKE 234 Query: 238 AIACWQ 243 I + Sbjct: 235 GIRILE 240 Score = 57.9 bits (139), Expect = 3e-07, Method: Composition-based stats. Identities = 23/95 (24%), Positives = 38/95 (40%), Gaps = 1/95 (1%) Query: 150 GVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDID 209 +S +L Y G + + D+ R T N + E+ + Q GGI DI+ Sbjct: 29 PISPVELALKYQEAGARLIHVVDLDRAFTGESENFEVIAEIIKNVS-IPVQVGGGIRDIE 87 Query: 210 DVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 L GV VIVG + ++E + ++ Sbjct: 88 SFRELIDLGVSRVIVGTIAVTNPELLEEMLTLDRD 122 >UniRef50_A9A5X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Thaumarchaeota RepID=HIS4_NITMS Length = 236 Score = 234 bits (598), Expect = 2e-60, Method: Composition-based stats. Identities = 77/239 (32%), Positives = 138/239 (57%), Gaps = 8/239 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+DL+DG VVRL++GD ++ Y +DP+ + + GA++LH+VDL Sbjct: 3 IIPAIDLMDGQVVRLYKGDPKQKTVYSDDPVSVAKKWQKAGADMLHIVDLDATI-GTGSN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI+ + +++PV+V GG+R+EE + + RVV+G+ A K ++M++ +++ Sbjct: 62 LDLIEKISKELSIPVEVAGGLRNEEIIDRAISF-SNRVVIGTMAFKDKEMLQRIAKKYDF 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D + + GWQE++ L + ++ +G L T++S+DGTL G Sbjct: 121 SKIVISVD-----HIDGFIVTHGWQESTKTPLLDAINEFVSMGFTEFLLTNVSKDGTLEG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ E+ CA +SGGI +IDDV+ ++ VI+G+AL E K +++EA Sbjct: 176 PDLEYLEKACA-VQNANVIASGGISNIDDVSDVQRKNAFAVILGKALYENKISIEEAKQ 233 >UniRef50_Q2JK82 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=91 Tax=Bacteria RepID=HIS4_SYNJB Length = 261 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 94/241 (39%), Positives = 140/241 (58%), Gaps = 8/241 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL+ G VRL+QGDY + +DP+ + + +AAQGA LH+VDL GAK Sbjct: 10 VIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P+I+ +V + +PVQVGGG+RS E LL+ GV RV+VG+ AV+ D ++ + F Sbjct: 70 LPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPG 129 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D R QVA GW + + +LV+ G ++ TDISRDGTLAG Sbjct: 130 -RVWVGIDARQ-----GQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRDGTLAG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVR-GVIVGRALLEGKFTVKEAIA 240 N+ ++ A QV +SGGIG + D+ AL G I+G+AL G +++EA+ Sbjct: 184 PNLEQLRQILA-VSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEALR 242 Query: 241 C 241 Sbjct: 243 A 243 >UniRef50_B2I5X7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=21 Tax=Bacteria RepID=HIS4_XYLF2 Length = 269 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 108/241 (44%), Positives = 150/241 (62%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PALD+ +G VVRL QGDY +Q Y + LPR Q +A GA +HLVDL AK Sbjct: 4 IVYPALDIRNGAVVRLQQGDYARQTRYDDQVLPRAQAFADSGATWMHLVDLDAAKAGGYT 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 PL++ + + VQ GGGVRS +DVA +L+AG ARVV+GS AV+ V W + FG Sbjct: 64 LAPLLRQITRATGLQVQTGGGVRSRDDVARILDAGAARVVIGSLAVRQMTCVIEWLQAFG 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +ALD R D G ++ V GW E + +LE L + Y GL+H+LCTDI+RDG L+ Sbjct: 124 PERITVALDTRQDAGGVWRLPVHGWTEVAEATLEALAQQYAAAGLRHLLCTDIARDGMLS 183 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ +Y + A P V Q SGG D+ DV A + G G+++G+ALLEG+ +KEA+ Sbjct: 184 GPNMDVYAYLRALVPAVQIQVSGGARDVADVVAAKMAGCAGIVLGKALLEGRLALKEAVQ 243 Query: 241 C 241 Sbjct: 244 H 244 >UniRef50_B1H0E7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=HIS4_UNCTG Length = 244 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 77/246 (31%), Positives = 141/246 (57%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ G VRL QG+ + Y DP+ + + ++GA+ LH+VDL GA Sbjct: 2 IIIPAVDIRQGNSVRLKQGNIDAETIYSKDPVFIAKLWKSKGAKRLHVVDLDGAFSGTNI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK + A V++PV+VGGG+R+ + + + + G A ++G+ A + ++VK R+G Sbjct: 62 NKAIIKNICAAVDIPVEVGGGIRNMDKIKEVFDIGAAYAILGTVAFNNPEIVKKAITRYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ +++A+D + + +VA+SGW++ + + +LV +G++ +L TDISRDG Sbjct: 122 SEKIIVAVDAK-----DGKVAISGWKDITPIEASELVNKLKEIGVQEILYTDISRDGMFT 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G + + +++ + +SGG+ ID++ L+ GV IVG AL F +++ Sbjct: 177 GPDFAGLKKLSE--SGMRIIASGGVKTIDNLVKLKKYEKDGVFAAIVGSALYTDDFKLED 234 Query: 238 AIACWQ 243 AI + Sbjct: 235 AIEEIE 240 >UniRef50_B2V9M8 Imidazole glycerol phosphate synthase subunit hisF n=10 Tax=Bacteria RepID=HIS6_SULSY Length = 252 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 64/244 (26%), Positives = 118/244 (48%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ D G DP+ Y +GA+ L +D+T + + Sbjct: 6 IIPCLDVDKGRVVKGV--NFVNLIDAG-DPVEIASVYDKEGADELVFLDITASSEDRNII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++K V +P+ VGGGVRS ED+ LLE G +V + + AVK+ +V+ RFG+ Sbjct: 63 LDVVKKTAETVFMPLTVGGGVRSLEDIRKLLENGADKVSINTAAVKNPSLVENAAIRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+D + + +V + G + +G+ + + +G +L T + +DGT +G Sbjct: 123 STIVVAIDAKKVGENKWEVYIHGGRTPTGIDAIEWAKAVESLGAGEILLTSMDKDGTKSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 ++ L + V + ++ +SGG G++ G + + + E Sbjct: 183 YDIELTKAV-SEAVKIPVIASGGAGNVQHFYEAFEYGKADACLAASLFHFKEIEISELKN 241 Query: 241 CWQN 244 +N Sbjct: 242 YLKN 245 >UniRef50_B0TDM7 Imidazole glycerol phosphate synthase subunit hisF n=157 Tax=root RepID=HIS6_HELMI Length = 261 Score = 234 bits (597), Expect = 3e-60, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 119/249 (47%), Gaps = 11/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ RD G DP+ Y +GA+ + +D+T + D Sbjct: 6 IIPCLDVHGGRVVKGT--NFVNLRDAG-DPVELAAVYDKEGADEVVFLDITASSDGRAIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ V +P VGGG+RS ED+ +L+AG ++ + ++AV++ ++ +FG+ Sbjct: 63 LDVVRRTAEEVFIPFTVGGGLRSVEDIREMLKAGADKISLNTSAVQTPKLISDGAWKFGS 122 Query: 122 DALVLALDVRIDEQ------GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +V+A+D R +V G ++ +G+ + + +G +L T + + Sbjct: 123 QCIVVAIDARRRRDAEGNPVEGWEVYTHGGRKPTGIDVLEWARRVEELGAGEILLTSMDK 182 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFT 234 DGT G ++ L V + + +SGG+G++D + G + ++T Sbjct: 183 DGTKDGYDIPLTRAV-SEAVTIPVIASGGVGNLDHIVEGLTVGKADAALAASIFHYREYT 241 Query: 235 VKEAIACWQ 243 + E + Sbjct: 242 IGETKEYLR 250 Score = 42.8 bits (100), Expect = 0.009, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 37/99 (37%) Query: 25 RDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRS 84 + G D L + GA + L + IPL + + V +PV GGV + Sbjct: 154 KPTGIDVLEWARRVEELGAGEILLTSMDKDGTKDGYDIPLTRAVSEAVTIPVIASGGVGN 213 Query: 85 EEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADA 123 + + L G A + ++ ++ G + + + Sbjct: 214 LDHIVEGLTVGKADAALAASIFHYREYTIGETKEYLRER 252 >UniRef50_C4L176 Imidazole glycerol phosphate synthase subunit hisF n=28 Tax=Bacteria RepID=HIS6_EXISA Length = 255 Score = 234 bits (597), Expect = 3e-60, Method: Composition-based stats. Identities = 66/243 (27%), Positives = 132/243 (54%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ ++ + RD G DP+ + Y GA+ L +D+T + + + Sbjct: 6 IIPCLDVKEGRVVKGI--EFVQLRDIG-DPVEIAKYYDESGADELVFLDITASTERRQTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + V +P+ VGGG+RS ED+++LL+AG +V + + AV+S +++ +RFG+ Sbjct: 63 LDVVSAVARKVFIPLTVGGGIRSLEDISSLLKAGADKVSLNTLAVESPSLIREAADRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+DV+ + G V G ++ + + + + +G +L T +++DG +G Sbjct: 123 QCIVVAIDVK-FKDGEYYVYTYGGKQKTDLLAVEWAKQVAALGAGELLVTSMNQDGKQSG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++S+ E++ + +SGG G+ + V V ++ L + K TV+E Sbjct: 182 YDLSILEQLR-EVVDIPIIASGGAGNAEHVVEALE-KVDAALLASILHDRKTTVEEVKHV 239 Query: 242 WQN 244 ++ Sbjct: 240 CKS 242 >UniRef50_P62353 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrio RepID=HIS4_DESVH Length = 249 Score = 233 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 75/247 (30%), Positives = 133/247 (53%), Gaps = 11/247 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL++G VRL +G + + +DP+ + + QG LH+VDL GA Sbjct: 2 IVFPAIDLMNGVCVRLRRGRADDETVFSSDPVATARHWQEQGGRWLHVVDLDGAFSGQPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 PLI+++ +++PVQ+GGG+R A LEAGV R+++G+ A++ D F Sbjct: 62 NAPLIRSICDALDIPVQLGGGIRDAATAKAYLEAGVERLIIGTIALEEPDAYAALCAEFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++LD ++ GW +SG+++++++ L G ++ TDI RDG Sbjct: 122 G-RIGVSLDA-----EGGKLKTKGWVADSGLTVDEVLPRLLEAGTAFIIYTDIDRDGMQT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL----RGTGVRGVIVGRALLEGKFTVK 236 G N+ E + A+ V ++GG+ ++DV AL R T ++G + GRA+ EG ++ Sbjct: 176 GVNLPALEHL-AKASTVPVIAAGGVATLEDVKALYPLSRTTNLQGAVSGRAIYEGTLDLR 234 Query: 237 EAIACWQ 243 A+ + Sbjct: 235 TAMDWIR 241 >UniRef50_Q5WX95 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Legionella pneumophila RepID=HIS4_LEGPL Length = 239 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 89/239 (37%), Positives = 142/239 (59%), Gaps = 2/239 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL G VRL QG + + + P+ R +A GA+ LH+VDL GA+ + Sbjct: 2 LVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ LI ++ + +Q GGG+RS E AG++++V+GS A+ + D+ E+ Sbjct: 62 QLELICSM-QKTGIAIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIK 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +VLALDVR+D + +A++GWQ NS SL ++V Y G+KH+LCTDI+ DG + Sbjct: 121 PENIVLALDVRVDTKV-PLLAINGWQNNSTSSLWEVVSYYENHGIKHILCTDIACDGMMN 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N LY++ +PQ+A+Q+SGGI + D+ L G+ VI+G L + +E + Sbjct: 180 GPNFDLYQQAVEYFPQIAWQASGGIRHMQDITTLGSLGISAVILGLMLYQDNVNFEELL 238 >UniRef50_B4W8G6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=B4W8G6_9CAUL Length = 243 Score = 233 bits (595), Expect = 5e-60, Method: Composition-based stats. Identities = 109/242 (45%), Positives = 148/242 (61%), Gaps = 1/242 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL G + + Y P RL +AA+GAE +H+VDL GA+ Sbjct: 2 LIYPAIDLKDGVCVRLMHGKFDQVTRYDEQPATRLSAFAAEGAEWIHVVDLDGAEAGEAV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI L ++V +Q GGGVRS DVA LL+ GV+RVVVGS AV + V W + FG Sbjct: 62 QHALIGELTKAIDVKIQSGGGVRSANDVAKLLDTGVSRVVVGSLAVTQPNDVAAWLKGFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ + LA DV+I E G A+ GW ++SGV L ++ Y KH+L TD+ RDG + Sbjct: 122 AEHITLAFDVKI-EDGVPVPALKGWTQSSGVDLWTALDRYPKGLFKHLLVTDVGRDGAMT 180 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ L E+ R P + Q+SGG+ +DD+AA++ G G IVGRAL E +FT+ +AIA Sbjct: 181 GPNLELLAEIRRRRPDLVLQASGGVSSLDDIAAVKSLGCNGAIVGRALYENRFTLPDAIA 240 Query: 241 CW 242 Sbjct: 241 TA 242 >UniRef50_A1ZT22 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZT22_9SPHI Length = 239 Score = 233 bits (594), Expect = 6e-60, Method: Composition-based stats. Identities = 87/231 (37%), Positives = 142/231 (61%), Gaps = 5/231 (2%) Query: 10 DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLV 69 +G VRL QGDY ++R Y DP+ Q YA +G + LH+VDL GAK A + + L++ + Sbjct: 12 NGQCVRLTQGDYSQKRVYDKDPIEMAQKYADEGFQRLHVVDLDGAKSGAPKHLALVEQMA 71 Query: 70 AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALD 129 A N+ + GGG+++ E V A+L+AG A +GS AVK ++ KGW + FG+D ++LA D Sbjct: 72 AKTNLTIDYGGGIKTTEQVQAVLDAGAAMANIGSLAVKQPEVFKGWLQTFGSDKILLASD 131 Query: 130 VRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEE 189 V+ +++A++ WQ+ S VS+ + ++P GL CTD+S+DG L G + LY + Sbjct: 132 VK-----GEKIAINAWQDESEVSIYDFIADFIPSGLTQFFCTDVSKDGLLQGVALELYCK 186 Query: 190 VCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 + ++P + +SGG+ + D+ L G+ GVIVG+A+ E + ++E Sbjct: 187 LKQKFPTMTIIASGGVASMQDIEDLNKEGIDGVIVGKAIYENRIALEELKQ 237 >UniRef50_Q4FNT6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=root RepID=HIS4_PELUB Length = 239 Score = 232 bits (593), Expect = 7e-60, Method: Composition-based stats. Identities = 76/242 (31%), Positives = 129/242 (53%), Gaps = 8/242 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ D VRL +GD+ + +Y P+ + Y G + LH+VDL GA Sbjct: 3 IFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGETVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +IK +V ++ ++VGGGVRS + + + AGV +V++GS A+K+++ +K ++F Sbjct: 63 LDIIKEIVHKFDLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKFP- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + L LD + + ++VSGW+ENS ++ G ++ TDI+RDGT Sbjct: 122 NKIALGLDAK-----DGYLSVSGWKENSNQLTLDFLKEVNDYGASRLIYTDINRDGTKES 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIA 240 N V A SGG+ IDD+ +G + G+IVG+A+ +G ++E + Sbjct: 177 PNFEETTNV-ANVSNCPVIISGGVSSIDDIKKAKGLKNIEGIIVGKAIYDGDIKLEELVK 235 Query: 241 CW 242 Sbjct: 236 EL 237 Score = 53.6 bits (128), Expect = 6e-06, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 50/122 (40%), Gaps = 1/122 (0%) Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 + A+D++ + + +S Y G K++ D+ T Sbjct: 2 KIFPAIDIKDKKCVRLIKGDFNNKTEYEISPVDQAGKYKDHGFKNLHIVDLDGALTGETV 61 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACW 242 N+ + +E+ ++ + + GG+ ID + GV VI+G A ++ K +KEA + Sbjct: 62 NLDIIKEIVHKF-DLKIEVGGGVRSIDSIEKYINAGVEKVILGSAAIKNKNFLKEACQKF 120 Query: 243 QN 244 N Sbjct: 121 PN 122 >UniRef50_A6Q4V9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=9 Tax=Proteobacteria RepID=HIS4_NITSB Length = 238 Score = 232 bits (593), Expect = 7e-60, Method: Composition-based stats. Identities = 82/244 (33%), Positives = 134/244 (54%), Gaps = 10/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL DG VRL +G + Y ++P + + G+ LHLVDL GA + Sbjct: 3 ILPAIDLKDGKAVRLTKGLMESAKIYSDEPWQVAKRFEEMGSRWLHLVDLNGAFAGEPKN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + IK + A ++ +++GGG+R EE + ++ G+ R+++GS AVK+ VK ++ Sbjct: 63 LEQIKKIRANTSLKIELGGGIRDEETIRKYIDLGIERLILGSIAVKNPQFVKAMAAKYP- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + VAV GW + S + L + G++ ++CTD+ +DGTL+G Sbjct: 122 --IAVGIDA-----IDGFVAVEGWAKTSTMRATDLAREFAKSGVQAIICTDVGKDGTLSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 NV + A + +SGG+ DI+D+ L+ TG V GVIVG+A EG ++EA Sbjct: 175 VNVDFTVSI-AEASGIDTIASGGVRDIEDIKKLQATGTVAGVIVGKAFYEGTLDLEEAFR 233 Query: 241 CWQN 244 QN Sbjct: 234 LVQN 237 >UniRef50_B1CBX0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Anaerofustis stercorihominis DSM 17244 RepID=B1CBX0_9FIRM Length = 234 Score = 232 bits (592), Expect = 8e-60, Method: Composition-based stats. Identities = 83/239 (34%), Positives = 136/239 (56%), Gaps = 7/239 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ D VRL QGDY KQ Y ++P +D+ +G + LH+VDL A Sbjct: 2 IIFPAIDIRDNKCVRLSQGDYDKQTVYFDNPFTVAEDFEKRGVKYLHIVDLDAALIGKLT 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK ++ N+ ++VGGG+R EE + ++ GV RV +G+ AVK +K E++ Sbjct: 62 NFDIIKKIITDTNMLIEVGGGIRGEEQIKKYVDIGVDRVSIGTKAVKDFAFLKEMSEKYP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + L+LDV+ ++ V + GW ENSG+ + ++ + L ++ TDI +DG L+ Sbjct: 122 Y-KISLSLDVK-----DEYVYIKGWSENSGILIWDYLDKIKDLPLTGIVVTDIKKDGMLS 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G + LY ++ + + SGG+ +DD+ L+ GVIVG+AL E KF+V++ I Sbjct: 176 GPSFELYRKL-KKATKHNIVVSGGVSSLDDINKLKEDDTYGVIVGKALYENKFSVEDII 233 >UniRef50_C6N0X3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Legionella drancourtii LLAP12 RepID=C6N0X3_9GAMM Length = 240 Score = 231 bits (590), Expect = 1e-59, Method: Composition-based stats. Identities = 87/241 (36%), Positives = 139/241 (57%), Gaps = 2/241 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+D+ G VRL QG + + + P+ R +A GA+ LH+VDL GA+ + + Sbjct: 2 ILIPAIDIQAGRCVRLKQGQFEQITIFDTPPVERAAYFAKIGAQRLHVVDLDGAQIGSMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+PLI ++ + VQ GGG+RS E AG+A +V+GS A+ ++++ + Sbjct: 62 QLPLICSM-QNTGINVQAGGGIRSLEQAKLCFSAGIANLVLGSIAISNRELATQIIQEIS 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++LALD+R+ G A GWQ S +L +V Y +G++ +LCTDI+ DG + Sbjct: 121 PKNIILALDIRLI-NGIPIPATHGWQTMSNRNLWDVVSYYQQLGIQQILCTDIACDGMMQ 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N SLY+E R+P + +Q+SGGI + +D+ AL GV I+G +L +G + E Sbjct: 180 GPNFSLYQEAVKRFPMIDWQASGGIRNQEDIEALDKLGVAAAILGLSLYQGTLHLAEYKP 239 Query: 241 C 241 C Sbjct: 240 C 240 >UniRef50_D2RTG3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=6 Tax=Euryarchaeota RepID=D2RTG3_9EURY Length = 244 Score = 231 bits (590), Expect = 1e-59, Method: Composition-based stats. Identities = 92/244 (37%), Positives = 142/244 (58%), Gaps = 8/244 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG VV+L QG+ G ++ YG DP+ + + +GAE LHLVDL GA + + Sbjct: 9 VIPAVDMQDGEVVQLVQGERGTEKTYG-DPVDAARRWLDEGAEALHLVDLDGAFEGQRAN 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V+VP Q+GGG+R+ +D LLE GV RV++G+ AV++ D+V ER Sbjct: 68 GDAIDEVLETVDVPTQLGGGIRTADDAVDLLERGVDRVILGTAAVENPDIVAEISERHP- 126 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D++V++LD + + +V V GW E +G+S E Y +G +L T++ +G L G Sbjct: 127 DSVVVSLDAK-----DGEVVVEGWTEGAGISPVDAAERYAELGAAAILFTNVDVEGKLEG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 E+ V +SGG+ ++DV AL G V+VG AL EGKFT+ EA + Sbjct: 182 VAAEPVRELV-EATDVPVIASGGVATLEDVRALEDAGAAAVVVGSALYEGKFTLAEAQSA 240 Query: 242 WQNA 245 ++ Sbjct: 241 IDSS 244 >UniRef50_UPI00016BFDF6 putative 1-(5-phosphoribosyl)-5- n=1 Tax=Epulopiscium sp. 'N.t. morphotype B' RepID=UPI00016BFDF6 Length = 236 Score = 231 bits (589), Expect = 2e-59, Method: Composition-based stats. Identities = 81/241 (33%), Positives = 136/241 (56%), Gaps = 7/241 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G +VRL +G Y + + Y DP L+ + +GA LH+VDL GAK Sbjct: 3 IFPAIDIKNGQIVRLTEGKYDQVKVYSKDPEEVLEHFTKEGATALHIVDLDGAKSGTIEN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IKT++ + Q+GGG+R E + L GV RV++G+ AV++ V+ +++ Sbjct: 63 QNTIKTILKNRHFVTQLGGGIRDESTINHYLNMGVDRVILGTVAVENPKFVEEMVKKY-D 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + + QV +GW NS V + + +G+ ++ TDIS+DG +AG Sbjct: 122 QQIAVGVDEK-----DGQVRANGWLVNSKVDAIEFCKMLTAMGVATIIYTDISKDGMMAG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +++ Y ++C +V +SGG+ I ++ L+ GV GVIVG+A+ EGK ++EA A Sbjct: 177 CDMASYRQLCKDR-KVNIIASGGVTSIAEIKELKRIGVAGVIVGKAIYEGKIALREATAI 235 Query: 242 W 242 Sbjct: 236 C 236 >UniRef50_B2UX21 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Firmicutes RepID=HIS4_CLOBA Length = 237 Score = 231 bits (589), Expect = 2e-59, Method: Composition-based stats. Identities = 83/243 (34%), Positives = 141/243 (58%), Gaps = 7/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+D+IDG VRL+QGDY K+ ND +++ GAE +HLVDL GAK Sbjct: 2 IILPAIDIIDGQAVRLYQGDYNKKEVVANDIFNIAKEFECLGAEYIHLVDLDGAKSGYCV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I L V+VP++VGGG+R+ E + L+E G++RV++G+ A++ + ++K E +G Sbjct: 62 NEKIILKLAQTVDVPIEVGGGIRNFETIEKLIENGISRVILGTIAMEDEGLLKKAIECYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + N V GW S ++ + +G+K ++ TDIS+DGTL Sbjct: 122 -EKISVGIDCK-----NGYVYGRGWLAESKLNYLDFAKNMESLGVKSIIVTDISKDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N + ++ + + +SGGI DI+++ L+ + G I G+A+ G ++KEAI Sbjct: 176 GPNFDMLMKL-KKLVNIDITASGGIRDIENIKELKNIDIYGAITGKAIYSGNLSLKEAID 234 Query: 241 CWQ 243 + Sbjct: 235 ITR 237 >UniRef50_B9E171 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=8 Tax=Bacteria RepID=HIS4_CLOK1 Length = 238 Score = 230 bits (588), Expect = 2e-59, Method: Composition-based stats. Identities = 77/244 (31%), Positives = 138/244 (56%), Gaps = 7/244 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+DL G VRL++GD Q DP + ++GA+ LH+VDL GA + Sbjct: 2 IILPAIDLKGGKCVRLYKGDMNSQEVVARDPFETALKFKSEGAQYLHMVDLDGALKGSGE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I +V V+VP++VGGG+R+ E + ++ GV+RV++G+ A+K++++V E + Sbjct: 62 NLDIISKIVKNVDVPIEVGGGIRNIETIDKFIKLGVSRVILGTAALKNKELVIKAVENY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + + A GW S + + +G++ ++ TDIS+DGTL Sbjct: 121 DEKIAVGIDAK-----DGVPAADGWTTLSKTNYIDFGKEMEKIGVQTLIFTDISKDGTLE 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+N+ ++ + +SGGI DI+D+ +L+ V G IVG+A+ ++K+AI Sbjct: 176 GTNLEQLLKL-KNSVKCNVIASGGIKDIEDIKSLKKENVYGAIVGKAIYAKTLSLKKAIE 234 Query: 241 CWQN 244 N Sbjct: 235 IGGN 238 >UniRef50_B2A6X1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A6X1_NATTJ Length = 246 Score = 230 bits (588), Expect = 3e-59, Method: Composition-based stats. Identities = 79/248 (31%), Positives = 139/248 (56%), Gaps = 13/248 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL +G VRL +G+ G ++ Y ++P + + QGA LHLVDL GA + + Sbjct: 5 LIPAIDLYEGECVRLTEGELGSKKVYSDNPSDMARHFQEQGASRLHLVDLEGAFQGSVKN 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ + V++PVQVGGG+RS E + L+ GV +V++G+ A +D ++ E F Sbjct: 65 STIIEKIANKVSIPVQVGGGIRSIEAIERLVNMGVDQVILGTKAYNDRDFLQSALELF-H 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++ +D++ +VA GW S + +G+ V+ TDIS+DG L G Sbjct: 124 KNIIVGVDIK-----GGKVATEGWVNVSDTKTYDYLSELTELGVPRVILTDISKDGKLQG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT------GVRGVIVGRALLEGKFTV 235 N+ L++E+ A + ++ SGG+ ++D+ ++ + GVI+G+AL EGK + Sbjct: 179 PNLELFKEL-AIFTELDLVLSGGMSSLEDINRIQKLQNEIAHNLAGVILGKALYEGKIDL 237 Query: 236 KEAIACWQ 243 + A+ + Sbjct: 238 QGALETIR 245 >UniRef50_Q3ICF4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alteromonadales RepID=HIS4_PSEHT Length = 242 Score = 230 bits (588), Expect = 3e-59, Method: Composition-based stats. Identities = 107/243 (44%), Positives = 158/243 (65%), Gaps = 1/243 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIPALD++ +VRL+QG Y + Y + RL++YA GA LHLVDL GA+DP+K+ Sbjct: 1 MIIPALDVLQNQIVRLYQGKYETVQFYPFELGARLKEYADSGAGKLHLVDLEGARDPSKK 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q I+ +NVP QVGGG+R E+DV+ L+AG +VV+GS AV+ ++ VK W E+FG Sbjct: 61 QWQHIQAATKALNVPYQVGGGIRCEQDVSDWLKAGANQVVIGSMAVEKREQVKAWIEQFG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A+ V+ALDV A GW S L +LV+ Y +G+ LCTDIS+DGT+ Sbjct: 121 AEHFVIALDVNKTA-TGWAPATHGWLTESEFGLLELVDFYANLGVIDFLCTDISKDGTMT 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + +LYE++ + Q+SGG+ +DD+ L+ G+ G+I+G++LL+G F+V+EA+A Sbjct: 180 GPSFALYEDLIKHNSTIKVQASGGVSSLDDIKKLKELGIGGIILGKSLLDGAFSVEEALA 239 Query: 241 CWQ 243 + Sbjct: 240 VTR 242 >UniRef50_C0W9Y4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Acidaminococcus sp. D21 RepID=C0W9Y4_9FIRM Length = 245 Score = 230 bits (587), Expect = 3e-59, Method: Composition-based stats. Identities = 75/244 (30%), Positives = 130/244 (53%), Gaps = 10/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL G VRL +G++ K+ Y DP + +A GA +H+VDL GA Sbjct: 6 LYPAIDLRGGMCVRLEKGNFSKETVYSKDPGAMARRFAEAGARTIHVVDLDGALAGKSEN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + IK ++ + ++VGGG+R+ E + LL GV++V++GS A+ +V+ F Sbjct: 66 LSAIKAILREGGISIEVGGGIRTYEQIEGLLSLGVSQVILGSAAIYDPQLVERANRDFPY 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+ +D + N A GW+++S ++ E L G + ++ TDISRDG + G Sbjct: 126 -KIVVGIDAK-----NGYAAADGWEKDSNLTAEALARRVAAAGTERIIFTDISRDGMMNG 179 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKEA 238 SN+ + + V +SGG+ ++D+ L+ G+ G I+G+AL G F++ +A Sbjct: 180 SNIEATAALY-QACGVPITASGGVSSLEDIRRLKARETDGIEGCIIGKALYAGAFSLSDA 238 Query: 239 IACW 242 + Sbjct: 239 LKIA 242 >UniRef50_C7TCJ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Lactobacillus rhamnosus RepID=C7TCJ1_LACRG Length = 249 Score = 230 bits (586), Expect = 4e-59, Method: Composition-based stats. Identities = 78/243 (32%), Positives = 129/243 (53%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL+ G VRL QGDY + DPL ++++ A G + LHLVDL GA+ Sbjct: 3 LYPAIDLLAGQSVRLTQGDYRQV-SLTADPLTQVKNLTATGLKHLHLVDLDGARSQQPIN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I T+ +++GGG+R+ + L AG+ R+++GS AV + ++V ++FGA Sbjct: 62 QAVISTIRQHTPAFIELGGGIRTLAIMDHYLNAGIDRLILGSVAVTNPELVTQAVQKFGA 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D R +VA GW S S L++ + G+ + TDI RDG + G Sbjct: 122 DKIAVGIDARA-----GKVATDGWLTTSTQSPTHLMQAMVRRGVTTFIVTDIGRDGMMKG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 NV+L + P V +SGG+ + D+ AL+ G++ ++G+A G F + + Sbjct: 177 PNVALLAMLHQTVPNVNIVASGGVHTLADLTALQTAGIQAAVIGKAWQTGSFPLNKLKEL 236 Query: 242 WQN 244 N Sbjct: 237 EDN 239 >UniRef50_A7I1W6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=17 Tax=Epsilonproteobacteria RepID=HIS4_CAMHC Length = 236 Score = 230 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 85/239 (35%), Positives = 139/239 (58%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL +G VRL +G+ + Y + P + +A GA+ LH+VDL GA + Sbjct: 3 ILPAIDLKNGFAVRLKKGEMNSAKIYSDKPWELAEKFADLGAKWLHIVDLDGAFAGEAKN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ +V N+ ++VGGG+R EE + +GV+R ++GS A+K+ + VK +++ Sbjct: 63 AKTIEKIVKSTNLKIEVGGGIRDEERIKFYKNSGVSRFILGSAALKNPEFVKQMAKKY-- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +D + N VA GW E S + +L + Y G++ ++CTDIS+DG L+G Sbjct: 121 -KIAVGIDAK-----NGFVATEGWAEVSNIKACELAKIYADAGVEAIICTDISKDGMLSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAI 239 NV EE+ A+ + +SGG+ D+ D+ AL+ +G + GVIVG+A EG +KEA Sbjct: 175 VNVKFSEEI-AKSSGIKTIASGGVKDLSDIKALKQSGKIYGVIVGKAYYEGSIDLKEAF 232 >UniRef50_D1RFK6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Legionella longbeachae D-4968 RepID=D1RFK6_LEGLO Length = 246 Score = 228 bits (583), Expect = 9e-59, Method: Composition-based stats. Identities = 86/241 (35%), Positives = 136/241 (56%), Gaps = 2/241 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL G VRL QG + + + P+ R +A GA+ LH+VDL GAK + Sbjct: 2 ILIPAIDLQAGRCVRLRQGQFDQVTQFDMSPIDRASYFAKLGAKRLHIVDLDGAKIGTMQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+PLI T+ V VQ GGG+RS E AG++ +V+GS A+ + Sbjct: 62 QLPLICTM-QHTGVTVQAGGGIRSLEQAKTCYSAGISLLVIGSIAITDPGLTTKIINEIS 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++LALD+R++ + A GWQ S ++L ++V Y +G+ +LCTDI+ DG + Sbjct: 121 PKNIILALDIRMENKI-PLPATHGWQTTSTMNLWEVVSFYQQLGITQILCTDIASDGMMQ 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N LY+E R+P +A+Q+SGGI DD+ L+ G++ I+G + + F +K ++ Sbjct: 180 GPNFDLYQEAVERFPNIAWQASGGIRHQDDINKLQKLGIKAAILGLTMYQDVFNLKSILS 239 Query: 241 C 241 Sbjct: 240 S 240 >UniRef50_Q58927 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Euryarchaeota RepID=HIS4_METJA Length = 237 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 78/244 (31%), Positives = 137/244 (56%), Gaps = 8/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL D V+L QGD K+ N+P+ + + +GAE LH++DL A Sbjct: 2 IIIPAVDLKDKKCVQLIQGDPNKKHLELNNPVEVAKKFVDEGAEYLHIIDLDAAF-GTGN 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +IK ++ VNVPV+VGGG+R+ E L+ GV RV+VG+ A+ + + G Sbjct: 61 NRDVIKNIIKEVNVPVEVGGGIRNLEIAKELISLGVDRVIVGTKAILEPKFIDDLNKEIG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +VLA++ + +V + GW+E + ++++ + + ++L T++ +G L Sbjct: 121 KDKIVLAVECK-----EGKVVIKGWKEKVDKTPIEVIKEFEDK-VGYILFTNVDVEGLLK 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G NV + +E+ + + SGGI ++D+ AL+ G+ GV++G AL +G +K+A+ Sbjct: 175 GINVDIIKELIEK-TDIPIIYSGGITTLEDIKALKELGIYGVVIGSALYKGLIDLKKALE 233 Query: 241 CWQN 244 +N Sbjct: 234 IVKN 237 >UniRef50_Q039B4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Lactobacillales RepID=HIS4_LACC3 Length = 238 Score = 226 bits (577), Expect = 5e-58, Method: Composition-based stats. Identities = 72/239 (30%), Positives = 119/239 (49%), Gaps = 6/239 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL++G VRL QGDY + DPL + Q G LHLVDL GA+ Sbjct: 3 LYPAIDLLNGKSVRLTQGDYDQV-SLTEDPLYQAQRLTDAGFAHLHLVDLDGARAQRPIN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + + +++GGG+R+ + L G+ R+++GS AV D+V+ RFG+ Sbjct: 62 RTVITRIREQTSAFIELGGGIRTLAAMEIYLTIGIDRLILGSAAVSDPDLVEQAIARFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + + +D R +VA +GW S + L+ G+ + TDI++DG + G Sbjct: 122 NRIAVGIDTRA-----GKVATNGWLTTSQQTANALLTAMQQRGVTTFIVTDIAKDGMMQG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 N L ++ PQ +SGGI + D+ L+ G++ I+G+A G + Sbjct: 177 PNAQLLADLQQAMPQATIIASGGISLLADLHRLQTAGIQAAIIGKAWQTGAIELAMLKQ 235 >UniRef50_Q0AP83 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Alphaproteobacteria RepID=HIS4_MARMM Length = 244 Score = 226 bits (577), Expect = 5e-58, Method: Composition-based stats. Identities = 112/245 (45%), Positives = 160/245 (65%), Gaps = 2/245 (0%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL+DG VVRLH+G + DYG+DP+ + + GA +H+VDL+GA+D A+R Sbjct: 2 ILYPAIDLLDGRVVRLHKGAFDAVTDYGDDPMRVAEQFGEAGAVWVHIVDLSGARDGARR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q LI++L + VQ GGGVRS ED+ LL AGV RV++GS AV + V GW + +G Sbjct: 62 QGALIRSLCE-TGLRVQTGGGVRSAEDIEDLLAAGVERVIIGSLAVTDTNRVAGWLQNYG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + LALDVR G + A+ GW + + +L+ ++ Y GL H L TDI RDG L+ Sbjct: 121 GDRITLALDVRQIG-GQYRPALKGWTDMADTTLDDVISAYEGTGLAHALVTDIGRDGDLS 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N++LY+ + YP + +Q+SGG+ +DD+ A R G G I G+AL EG+FTV EAIA Sbjct: 180 GPNIALYKRLATDYPNIDWQASGGVSSLDDLRAARAAGAAGAITGKALYEGRFTVGEAIA 239 Query: 241 CWQNA 245 C ++A Sbjct: 240 CLRDA 244 >UniRef50_P62356 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Thermus RepID=HIS4_THET2 Length = 235 Score = 226 bits (577), Expect = 5e-58, Method: Composition-based stats. Identities = 87/238 (36%), Positives = 132/238 (55%), Gaps = 8/238 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL G VRL++GD ++ YG DP+ + +GA +LHLVDL A Sbjct: 3 LIPAVDLKSGKAVRLYEGDPARETPYG-DPVEAALRFQEEGATLLHLVDLDRAL-GTGEN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ + A +++P Q+ GG+RS E + L G +R VVG+ AVK ++ E G Sbjct: 61 REAVRRVAASLSIPFQLAGGIRSLEALQEALSLGASRAVVGTVAVKDPGLLARMLEAVGP 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D L +ALD R +V VSGWQE + S L+ + +G++ +L TD+ RDGTL G Sbjct: 121 DRLAVALDAR-----GLEVVVSGWQEAASASALDLLRAWAEMGVRTLLYTDVRRDGTLLG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAI 239 + + V A +P GGI +D+ L+ GV G ++G+AL EG+ +KEA+ Sbjct: 176 LDREVVARVRAAWPH-ELIVGGGIASPEDLHLLQALGVDGALIGKALYEGRIRLKEAV 232 Score = 48.6 bits (115), Expect = 2e-04, Method: Composition-based stats. Identities = 20/92 (21%), Positives = 34/92 (36%) Query: 27 YGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEE 86 L L+ +A G L D+ ++ + A + VGGG+ S E Sbjct: 143 ASASALDLLRAWAEMGVRTLLYTDVRRDGTLLGLDREVVARVRAAWPHELIVGGGIASPE 202 Query: 87 DVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 D+ L GV ++G + + +K R Sbjct: 203 DLHLLQALGVDGALIGKALYEGRIRLKEAVWR 234 >UniRef50_C7P985 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=C7P985_METFA Length = 272 Score = 226 bits (576), Expect = 6e-58, Method: Composition-based stats. Identities = 67/263 (25%), Positives = 127/263 (48%), Gaps = 24/263 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ + + RD G DP+ Q Y +GA+ L +D+T + + Sbjct: 6 IIPCLDIKDGRVVKGTK--FLNLRDAG-DPVELAQLYDDEGADELVFLDITASAEKRDII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ V +P+ VGGG++S ED +L AG ++ + + AVK+ +++K E FG+ Sbjct: 63 IDVVERTAEKVFIPLTVGGGIKSIEDFRKILRAGADKISINTAAVKNPNLIKEASEIFGS 122 Query: 122 DALVLALDVRI-------------------DEQGNKQVAVSGWQENSGVSLEQLVETYLP 162 +V+A+D + D +V + G ++ +G+ + + Sbjct: 123 QCVVVAIDAKRHYINEDEIDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKVEE 182 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRG 221 +G +L T I +DGT +G ++ L E+ ++ ++ +SGG G + V G Sbjct: 183 LGAGEILLTSIDKDGTKSGYDLILTREI-SKSVKLPVIASGGCGKPEHVYEAFVHGKADA 241 Query: 222 VIVGRALLEGKFTVKEAIACWQN 244 ++ L ++T++E + Sbjct: 242 ALMAGILHYKEYTIEEIKKYCAD 264 Score = 46.3 bits (109), Expect = 8e-04, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 48/125 (38%), Gaps = 7/125 (5%) Query: 6 LDLIDGTVVRLHQG-------DYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 +D ID VV++ G YG +++ G D + + GA + L + + Sbjct: 141 IDKIDKNVVKVEDGYCWFEVYIYGGRKETGIDAIEWAKKVEELGAGEILLTSIDKDGTKS 200 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + L + + V +PV GG E V G A + + + ++ ++ Sbjct: 201 GYDLILTREISKSVKLPVIASGGCGKPEHVYEAFVHGKADAALMAGILHYKEYTIEEIKK 260 Query: 119 FGADA 123 + AD Sbjct: 261 YCADR 265 >UniRef50_Q18DL2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=6 Tax=Halobacteriaceae RepID=HIS4_HALWD Length = 245 Score = 226 bits (576), Expect = 6e-58, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 138/243 (56%), Gaps = 8/243 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+D+ DG VV+L QG+ G + YG DP+ + + GA+ LHLVDL GA + + Sbjct: 10 VIPAVDMQDGDVVQLVQGERGTETRYG-DPVVAAKQWVEAGAKTLHLVDLDGAFEGDRMN 68 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V++PVQ+GGG+R+ D A+LL+ GV RV++G+ AV++ D+V E + Sbjct: 69 ATAVDAIIDAVDIPVQLGGGIRTANDAASLLDRGVNRVILGTAAVENPDLVAELAESYPG 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++++LD + +V VSGW E++G+ + G +L TD+ +G LAG Sbjct: 129 -RIIVSLDA-----ADGEVVVSGWTESTGIDPAVAAARFADYGACGILFTDVDVEGKLAG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 S+ V + +SGG+ +DD+ L TG +VG AL E KFT+ +A+ Sbjct: 183 IQSSVTARVI-DAVDIPVIASGGVASLDDIQTLHTTGAAATVVGTALYENKFTLADAMEV 241 Query: 242 WQN 244 ++ Sbjct: 242 CES 244 Score = 55.6 bits (133), Expect = 1e-06, Method: Composition-based stats. Identities = 34/121 (28%), Positives = 51/121 (42%), Gaps = 5/121 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II +LD DG VV G G DP +A GA + D+ A Q Sbjct: 130 IIVSLDAADGEVV--VSGWTEST---GIDPAVAAARFADYGACGILFTDVDVEGKLAGIQ 184 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V++PV GGV S +D+ L G A VVG+ +++ + E + Sbjct: 185 SSVTARVIDAVDIPVIASGGVASLDDIQTLHTTGAAATVVGTALYENKFTLADAMEVCES 244 Query: 122 D 122 D Sbjct: 245 D 245 >UniRef50_UPI0001C41EB6 phosphoribosylformimino-5- aminoimidazole carboxamide ribotide isomerase HisA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41EB6 Length = 246 Score = 226 bits (576), Expect = 6e-58, Method: Composition-based stats. Identities = 69/241 (28%), Positives = 135/241 (56%), Gaps = 7/241 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+D+ G V+L QG G ++ +P + + GAEV+H++DL GA + + Sbjct: 9 LIMPAVDIRGGKCVQLVQGKPGSEQVVIENPEKVAKKWEDAGAEVVHVIDLDGALE-SVT 67 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I IK ++ V+VP+Q+GGG+RS E LL + R+++G+ +K+ +++ +G Sbjct: 68 NIETIKKILNEVSVPIQLGGGIRSIEYAEELLNLDIDRLIIGTMGIKNPEIISKLSNEYG 127 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ ++++LD + + +V + GWQE S ++ + + +G +L T++ +G L Sbjct: 128 SERVMISLDSK-----DNKVVIKGWQEKIDKSASEISKEFQELGAGSILFTNVDVEGLLG 182 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G V ++ + SGG+ +DD+ L+ TG +GV++G AL + K +++A+ Sbjct: 183 GFYVDPVIDLV-DSVDIPVVYSGGVTSLDDLKQLQTTGAKGVVIGSALYKDKIKLEDALK 241 Query: 241 C 241 Sbjct: 242 Y 242 >UniRef50_UPI0001C3165B phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3165B Length = 246 Score = 226 bits (576), Expect = 7e-58, Method: Composition-based stats. Identities = 85/246 (34%), Positives = 139/246 (56%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+D+ G+ VRL QGD+ + Y DPL + + GA LH+VDL GA+D Sbjct: 2 ILYPAIDIRGGSAVRLRQGDFADETVYDADPLSAARAWVEGGARWLHVVDLDGARDGRPA 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++ + + VPV+ GGG+RS V A +EAG RV++G+ A D + +G Sbjct: 62 NLEHLRRIAGELGVPVEFGGGLRSRASVDAAIEAGAERVILGTAAFADVDFLDDVVAAYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+++DVR +VA +GW+E + + +++ G++ ++ ++I RDG L Sbjct: 122 -ERVVVSVDVR-----GGKVASAGWKEQTEMEAAAVIDHLQRRGVRKLVYSNIERDGMLT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA---LRGTGVRGVIVGRALLEGKFTVKE 237 G ++ V A + +F SGGIG +D +AA LR + GVIVG+AL E KFTV + Sbjct: 176 GPDLDEVRRV-AESVRGSFIYSGGIGSLDHLAALASLRQVNLNGVIVGKALYERKFTVGD 234 Query: 238 AIACWQ 243 A+ + Sbjct: 235 ALTALK 240 >UniRef50_B0SDS6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Leptospira biflexa serovar Patoc RepID=HIS4_LEPBA Length = 247 Score = 226 bits (576), Expect = 7e-58, Method: Composition-based stats. Identities = 81/246 (32%), Positives = 137/246 (55%), Gaps = 8/246 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+DL+D VRL QGDY K+ Y + P +Q + QGA ++H+VDL AK Sbjct: 2 LVLPAIDLLDNEAVRLLQGDYSKKTVYSSSPEKMIQVFEEQGATLIHIVDLNAAKTGKSE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 IK + V +++GGG+R+ +++ GV+R+++G+ AV+ ++V+ FG Sbjct: 62 NEKTIKKIKEKCTVDLELGGGIRTIDNMKFYDGLGVSRLILGTVAVEEPNVVEKAVSLFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D +V+ +D + N V GW+ NSG+ + + T +G++HV+ TDI+RDG + Sbjct: 122 QDRIVIGVDAK-----NGYVRTKGWESNSGILYKDFLTTMYGMGIRHVIFTDIARDGMME 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N Y E+ +P + +SGG+ +D+ L + G I G+A+ EGK +KE Sbjct: 177 GPNTLAYAELLETFPDLQLVASGGVSSKEDLVELYDKTNGKLFGAITGKAIYEGKLDLKE 236 Query: 238 AIACWQ 243 +I Sbjct: 237 SIRILN 242 >UniRef50_C4G189 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Abiotrophia defectiva ATCC 49176 RepID=C4G189_ABIDE Length = 238 Score = 225 bits (575), Expect = 9e-58, Method: Composition-based stats. Identities = 74/241 (30%), Positives = 143/241 (59%), Gaps = 7/241 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ +G VVRL +GDY K Y + + + + A G E LHLVDL GAK+ Sbjct: 5 IIFPAIDIYEGKVVRLLKGDYNKMTIYSENVVDKACEIEAAGGEWLHLVDLEGAKEGNTP 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ + + V++GGG+R+E + + AGV R+++G+ A ++ + +++ Sbjct: 65 NFTYVEEICKKTGLKVEIGGGIRTEATIEKYINAGVNRIILGTKAATDKEFLNKMTDKY- 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +DV+ +++VA+ GW E + ++ V +G+K+++ TDI++DG ++ Sbjct: 124 REKIAVGIDVK-----DEKVAIKGWLEVTDKTIFDFVTELKEIGIKNIIVTDIAKDGAMS 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G NVS YE++ +++ + +SGG+ +DD+ L+ TG+ G I+G+A+ G ++EA+ Sbjct: 179 GINVSFYEKL-SKFTDMDITASGGVTTLDDLIRLKNTGIYGAILGKAMYTGNVDLREALK 237 Query: 241 C 241 Sbjct: 238 I 238 >UniRef50_D1Y7T0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y7T0_9BACT Length = 237 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 129/243 (53%), Gaps = 7/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL G VRL +GDY + Y + P D+AAQGA LHL+DL GAK+ Sbjct: 2 LIYPAIDLYAGQAVRLQRGDYARMTVYSDRPETVAADFAAQGARQLHLIDLEGAKNGGTP 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I + + QVGGG+RS + + A L+AGV RV++G+ A R+G Sbjct: 62 NLETIVAVKKSSGLFCQVGGGIRSMDAIVAYLDAGVDRVILGTAAATQAHFAARAVARYG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A + + +D++ + AV GW E S + + G+ ++CTDISRDG + Sbjct: 122 A-RIAVGVDIK-----DGFAAVKGWTEKSPLKAFEFCRRMQSDGVSTLICTDISRDGMMQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G+NV+LY+ + ++ +SGG+ +DDV L G+ G I+G+A ++ AI Sbjct: 176 GTNVALYKTLSTEL-KMRIIASGGVSSLDDVRRLAALGLYGAIIGKACYTKAISIAAAIE 234 Query: 241 CWQ 243 Q Sbjct: 235 VTQ 237 >UniRef50_C0QWR6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=12 Tax=Bacteria RepID=HIS4_BRAHW Length = 238 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 77/242 (31%), Positives = 137/242 (56%), Gaps = 7/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+DL +G VVRL +G+Y + Y DPL L + G+ LH+VDL GA D Sbjct: 3 ILPAIDLKNGEVVRLVEGNYDNKTTYFKDPLEVLDFFIESGSSYLHVVDLDGASDGETIN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ ++ ++ V+VGGG+R+E+ + L+ GV R ++G+ AV++ D ++ Sbjct: 63 FKTIEKVIKKCDLFVEVGGGIRNEDTIKKYLDIGVKRTILGTAAVENIDFTNNMINKY-K 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + +++D R ++ +AV GW+E + + +G+ ++ TDIS+DG L+G Sbjct: 122 EHIAVSIDSR-----DRMIAVKGWKEINKQDSVEFCMKLDSMGIDTIIYTDISKDGKLSG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +N+ +Y+E+ + +SGG+ D++ LR + G IVG+A+ EGK +K+ I Sbjct: 177 TNLDIYKELREKIS-CNIIASGGVTFEDEIIKLRDMKINGAIVGKAIYEGKIDLKKIIEI 235 Query: 242 WQ 243 + Sbjct: 236 AK 237 >UniRef50_C1TLB3 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLB3_9BACT Length = 239 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 87/241 (36%), Positives = 139/241 (57%), Gaps = 10/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL VVRL GD+ K ++YG+DP+ +A GA +HL+DL GA+ + Sbjct: 6 IYPAIDLYSRKVVRLTGGDFEKIKEYGDDPVETALSFAEAGARWIHLIDLEGAEKGSPVH 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + A +PVQ GGG+R+EEDVA L +G RV +GS K + ++RFG Sbjct: 66 LKELEKVAASTGLPVQYGGGLRTEEDVALALSSGAKRVYLGSLLFKGSP--RTLWKRFG- 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++V ++DV+ N VA+SGW E + + E+ + L +G L T +SRDGT +G Sbjct: 123 NSIVPSVDVK-----NGTVALSGWTEVTQLPPEEAITELLRIGYSTFLVTSVSRDGTASG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++ LYE + ++GGI D D+A L GV G ++G+++ EG ++EA+ Sbjct: 178 PDLKLYERLKK--TDGRILAAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAVEE 235 Query: 242 W 242 + Sbjct: 236 F 236 Score = 46.3 bits (109), Expect = 9e-04, Method: Composition-based stats. Identities = 26/119 (21%), Positives = 51/119 (42%), Gaps = 6/119 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P++D+ +GT V L Q P + + G + ++ + Sbjct: 125 IVPSVDVKNGT-VALSGWTEVTQLP----PEEAITELLRIGYSTFLVTSVSRDGTASGPD 179 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + L + L + + GG+R ++D+A L E GV+ V+G + + ++ E FG Sbjct: 180 LKLYERLKK-TDGRILAAGGIRDKKDLADLAEIGVSGAVLGKSIYEGTVDLREAVEEFG 237 >UniRef50_A6C5Q1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Planctomycetaceae RepID=A6C5Q1_9PLAN Length = 246 Score = 224 bits (572), Expect = 2e-57, Method: Composition-based stats. Identities = 88/250 (35%), Positives = 135/250 (54%), Gaps = 13/250 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+PA+D+ G VRL QGDYG++ +G+DP + +A GA+ LHLVDL GAK Sbjct: 3 ILPAIDIRGGKCVRLRQGDYGQETVFGDDPTEMARRWADGGAQRLHLVDLDGAKAGQPVN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALL-EAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ +V V+VP Q+GGG+R E + +L E G+ RV+VG+ A+K K +R+ Sbjct: 63 HEVVRKIVEAVSVPCQMGGGIRDEASIQLMLDEVGIDRVIVGTQALKDPQWFKQMVQRYP 122 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + L L LD R + +VA GW + S S L + Y+ V L V+ T+I+ DG + Sbjct: 123 -NRLALGLDAR-----DSKVATEGWLDVSETSAIDLAKEYVGVELAAVIYTNIANDGMMQ 176 Query: 181 GSNVSLYEEVCARY-PQVAFQSSGGIGDIDDVAALRGT-----GVRGVIVGRALLEGKFT 234 G + +++ A + +SGG+ + DV+ L + G I+GRAL EG Sbjct: 177 GVDEGTIQDMIALAELGLPVIASGGVTTLKDVSRLAEVSRTQPKLVGAIIGRALYEGTIE 236 Query: 235 VKEAIACWQN 244 V AI + Sbjct: 237 VPAAIEAAGS 246 >UniRef50_C1CY68 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Deinococci RepID=C1CY68_DEIDV Length = 251 Score = 224 bits (572), Expect = 2e-57, Method: Composition-based stats. Identities = 83/233 (35%), Positives = 130/233 (55%), Gaps = 7/233 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIP +D+ G VRL++GD ++ Y + PL + + +GA ++HLVDL A Sbjct: 18 LIIPCVDIQSGRAVRLYEGDPERETVYFDSPLDAARHWVERGAGLVHLVDLDAA-TGRGE 76 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I+ + + + VPV+VGGG+R E LL AGV RVV+G+ AV++ +V G Sbjct: 77 NREVIRQITSELGVPVEVGGGIRDREAAEDLLRAGVHRVVIGTAAVRNPQLVADLIAAHG 136 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V++LD R +VA GW + SGV++ +L GL+ ++ TD++RDGTL Sbjct: 137 PERVVVSLDAR-----GLEVATHGWAQGSGVNVAELTPGLADAGLELLIFTDVTRDGTLK 191 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G N L +V + GG+ ++DDV L+ + G IVGRA+ EG Sbjct: 192 GLNRELMRQVRQLWINT-LIVGGGVANMDDVRLLQEERIEGAIVGRAIYEGTL 243 >UniRef50_B8J249 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=Desulfovibrionales RepID=HIS4_DESDA Length = 250 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 79/249 (31%), Positives = 131/249 (52%), Gaps = 12/249 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+D+ +G VRL QG + + P+ + + GA LH+VDL GA D A + Sbjct: 2 IIFPAVDIQNGKAVRLKQGRAHESTVFAESPVDAARAWEEAGARWLHVVDLDGAFDGAAQ 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ + A + +PVQ+GGG+R A LEAGV+R+++G+ A++ + F Sbjct: 62 SRRIVRDICAALAIPVQLGGGIRDMHTAEAYLEAGVSRLIIGTLALEQPTLFADMCRAFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++LD ++ GW E++G++++ + L G V+ TDI RDG Sbjct: 122 G-RVGVSLDA-----EGGRLKSRGWVEDTGMTVDTALPRLLDDGAAFVIYTDIERDGMQC 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR----GTGVRGVIVGRALLEGKFTVK 236 G NV+ E + AR V ++GG+ ++D+ L T + G + GRAL EG +K Sbjct: 176 GVNVAALEHL-ARLSTVPVIAAGGVATLEDIQKLYPLTLETSLMGAVSGRALYEGTLDLK 234 Query: 237 EAIACWQNA 245 EA W +A Sbjct: 235 EA-NAWIDA 242 >UniRef50_D0LIZ1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Nannocystineae RepID=D0LIZ1_HALO1 Length = 239 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 86/242 (35%), Positives = 134/242 (55%), Gaps = 7/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL+ G VVRLHQG + Y N+P ++ +A+ GAE +H+VDL GA + Sbjct: 3 IYPAIDLLGGNVVRLHQGKRSEALVYSNEPAEIVRRFASAGAERVHVVDLDGAFSGERAH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + A VP+QVGGG+R + A+ G V+G+ AVK+ + Sbjct: 63 REALAEMAAASPVPLQVGGGIRDRAALEAVFATGAGFAVLGTAAVKNPAFAREACAAHPG 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++A+D R + VA+ GW E++G++ E+L + G +L TD+ RDG G Sbjct: 123 -CVIVAVDAR-----DGVVAIEGWVESAGITAEELGKRAADWGAAGLLYTDVMRDGAQVG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N++ + A+ + +SGG+G +DD+ AL GV V+VGRAL E KFT+ EA+A Sbjct: 177 PNIATTAAL-AQAVDIPVIASGGVGTLDDIRALAAAGVPSVVVGRALYENKFTLPEALAA 235 Query: 242 WQ 243 + Sbjct: 236 AR 237 >UniRef50_A6UUZ9 Imidazole glycerol phosphate synthase subunit hisF n=27 Tax=cellular organisms RepID=HIS6_META3 Length = 275 Score = 223 bits (569), Expect = 4e-57, Method: Composition-based stats. Identities = 62/267 (23%), Positives = 122/267 (45%), Gaps = 28/267 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ ++ + RD G DP+ + Y QGA+ L +D+ + + Sbjct: 6 IIPCLDIKNGRVVKGT--NFVELRDAG-DPVELSKIYNEQGADELVFLDIGASHEKRDII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ V +P+ VGGG+R+ +D +L AG ++ V + A+ + D++K E +GA Sbjct: 63 EHLVEKTADQVFIPLTVGGGIRTTDDFRRILRAGADKISVNTAAIHNPDLIKQSSELYGA 122 Query: 122 DALVLALDVRI-----------------------DEQGNKQVAVSGWQENSGVSLEQLVE 158 +V+A+D + ++ +V + G ++ +G+ + + Sbjct: 123 QCVVVAIDSKRHYVNEEDLDSKQLEDKNVVKVDKNKYCWFEVFIYGGRKETGIDAIEWAK 182 Query: 159 TYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG 218 T +G +L T + DGT G ++ L + + ++ +SGG G + + G Sbjct: 183 TAEELGAGEILLTSMDADGTKDGYDIELTKSISTHI-KLPVIASGGCGAPQHIHQVFEYG 241 Query: 219 -VRGVIVGRALLEGKFTVKEAIACWQN 244 ++ L ++TV E + Sbjct: 242 KADAALMASILHYREYTVGELKKYCMD 268 >UniRef50_C9RH20 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Methanocaldococcus RepID=C9RH20_METVM Length = 237 Score = 223 bits (568), Expect = 6e-57, Method: Composition-based stats. Identities = 74/244 (30%), Positives = 130/244 (53%), Gaps = 8/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL D V+L QGD K+ DP+ + + GAE LH+VDL A Sbjct: 2 IVIPAVDLKDKKCVQLIQGDPTKKHLELEDPVNVAKKWVHDGAEYLHIVDLDAALGCG-N 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I+ +V VN+PV+VGGG+RS L++ GV ++VVG+ A+ + Sbjct: 61 NVDVIEKIVEEVNIPVEVGGGIRSLTIAKRLMDIGVDKIVVGTKAITDPTFLNELLSEIE 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++LA++ + +VA+ GW+E + ++ + Y + +L T++ +G L+ Sbjct: 121 REKIILAVECKQ-----GKVAIKGWKETINKNPIEIAKKYEKK-VGGILFTNVDVEGMLS 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + E + +V SGGI ++D+ L+ GV GVI+G AL +G +K+A+ Sbjct: 175 GIKTDIIETLVKN-VRVPIIYSGGITTLEDIKKLKEIGVDGVIIGSALYKGIINLKDALK 233 Query: 241 CWQN 244 ++ Sbjct: 234 ISKS 237 >UniRef50_B8IPH4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=142 Tax=cellular organisms RepID=HIS4_METNO Length = 253 Score = 222 bits (566), Expect = 9e-57, Method: Composition-based stats. Identities = 82/248 (33%), Positives = 132/248 (53%), Gaps = 10/248 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL +G VRL QGD + + +DP + +A QG LH+VDL GA A Sbjct: 5 ILFPAIDLKEGRCVRLVQGDMAQAIVFSDDPAAQAASFAEQGFSWLHVVDLDGAFAGAPM 64 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++A V +PVQ+GGG+R V L GV+RV++G+ AV+ V+ F Sbjct: 65 NAAAVDAILAAVTIPVQLGGGIREMRTVEGWLAKGVSRVIIGTAAVRDPAFVREAARLFP 124 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +D + + +VAV GW + S V+ E+L + G+ ++ TDI+RDG L Sbjct: 125 G-RIAVGIDAK-----DGRVAVEGWAKTSTVTAEELGRRFEDAGVAALIYTDIARDGVLK 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGV---RGVIVGRALLEGKFTVKE 237 G N+ + + A+ + +SGG+ I+DV + G I GRAL +G+ +E Sbjct: 179 GLNIPMTLAL-AQAVSIPVIASGGLASIEDVHRILEPDCALLAGAITGRALYDGRIDPRE 237 Query: 238 AIACWQNA 245 A+A + A Sbjct: 238 ALAAIRRA 245 >UniRef50_B9KXJ4 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermomicrobium roseum DSM 5159 RepID=HIS4_THERP Length = 244 Score = 221 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 94/238 (39%), Positives = 142/238 (59%), Gaps = 9/238 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL +G VRL +GD+ + Y +DP+ Q +A+ GA LH+VDL GA+ Sbjct: 2 IVIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPV 61 Query: 61 QIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 Q LI+ ++ V +V VQVGGGVR+ + V LL G ARVV+G+ A++ DM++ RF Sbjct: 62 QHELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALARF 121 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G + +V+A+D R + VA GW+ + +E++V + +G++ VL TD++RDGTL Sbjct: 122 GVERVVVAVDSR-----DGWVATHGWETVQAIRVEEVVHRVVLLGVRRVLATDVTRDGTL 176 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVK 236 N+ L + A V +SGG+G D+ AL GV IVGRAL EG+ + Sbjct: 177 TRPNLELMGRLAAL--GVTVIASGGVGSRSDLEALARVPGVEAAIVGRALYEGRVRFE 232 Score = 54.4 bits (130), Expect = 4e-06, Method: Composition-based stats. Identities = 26/117 (22%), Positives = 44/117 (37%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 ++ A+D+R ++ + + G + + D+ Sbjct: 3 VIPAIDLREGRCVRLFRGDFARATVYSDDPIEMAQRWASAGARWLHVVDLDGARLGQPVQ 62 Query: 184 VSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 L E V P VA Q GG+ +D V L G V++G A LE ++EA+A Sbjct: 63 HELIERVIRAVPDVAVQVGGGVRTLDAVERLLVGGAARVVIGTAALERPDMLREALA 119 >UniRef50_Q1IWD2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Deinococcus RepID=HIS4_DEIGD Length = 243 Score = 221 bits (563), Expect = 2e-56, Method: Composition-based stats. Identities = 89/233 (38%), Positives = 130/233 (55%), Gaps = 7/233 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIP +D+ G VRL++GD ++ Y PL + +AA GA ++HLVDL A Sbjct: 11 LIIPCVDIQSGRAVRLYEGDPDRETVYFESPLEAARHWAALGAGLVHLVDLDAA-TGRGE 69 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + A + VPV+VGGG+R ALL+AGV RVV+G+ AVK+ +V+ G Sbjct: 70 NRAVITQITAELGVPVEVGGGIRDRAAAEALLDAGVGRVVIGTAAVKNPALVRELIAAHG 129 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V++LD R VA+ GW E SGVS+ +L GL+ ++ TD++RDGTL Sbjct: 130 PSRVVVSLDAR-----GLDVAIHGWAEGSGVSVAELAPLLAEAGLETLIFTDVTRDGTLR 184 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G + L +V + GG+ +DDV L G++G IVGRA+ EG Sbjct: 185 GLDRDLMRQVRQLWSNT-LIVGGGVATLDDVRLLAEEGIQGAIVGRAIYEGTL 236 Score = 43.6 bits (102), Expect = 0.005, Method: Composition-based stats. Identities = 24/90 (26%), Positives = 38/90 (42%), Gaps = 2/90 (2%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 S + + +G V D+ T G N ++ ++ A V + GGI D Sbjct: 40 SPLEAARHWAALGAGLVHLVDLDA-ATGRGENRAVITQITAEL-GVPVEVGGGIRDRAAA 97 Query: 212 AALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 AL GV V++G A ++ V+E IA Sbjct: 98 EALLDAGVGRVVIGTAAVKNPALVRELIAA 127 >UniRef50_A3HVE8 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Algoriphagus sp. PR1 RepID=A3HVE8_9SPHI Length = 244 Score = 220 bits (562), Expect = 2e-56, Method: Composition-based stats. Identities = 69/237 (29%), Positives = 124/237 (52%), Gaps = 3/237 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP++ LI+G VRL +GD+ + N+PL Q + + G + LHLVDL GA+ + Sbjct: 4 VIPSIWLINGKCVRLKRGDFATEEAISNNPLEIAQGFESIGIKRLHLVDLDGARRGEPKN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + N+ V GGV ++ DV E G V + S A + + +G Sbjct: 64 YHILEAIAGYTNLHVDFTGGVTTDGDVIKSFEFGAKTVTISSAAANYPERFSQFILSYGR 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + LA D ++++ + GW + + + L +E + GLK++ C+D++RDG + G Sbjct: 124 EKINLAAD---TNPADRKIKIRGWLKKTEIDLYDHIEFFYDRGLKYLKCSDVTRDGVMVG 180 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 N LY ++ ++P + +SGG+ I+D L+ GV + GRA EG +++ Sbjct: 181 PNFELYADLVKKFPNLNIAASGGVRSIEDFKELKKLGVNAAVFGRAYYEGMLKLEDL 237 >UniRef50_Q12UY6 Imidazole glycerol phosphate synthase subunit hisF n=354 Tax=cellular organisms RepID=HIS6_METBU Length = 273 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 64/264 (24%), Positives = 121/264 (45%), Gaps = 26/264 (9%) Query: 2 IIPALDL----IDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 IIP LD+ GTVV+ ++ + G DP+ + Y QGA+ L +D+T + + Sbjct: 6 IIPCLDVTLDASGGTVVKGV--EFVDLKKAG-DPVDLAKRYNEQGADELVFLDITASHEG 62 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 I +I+ V +P+ VGGG+ S EDV +L AG +V V + AVK+ + ++ Sbjct: 63 RSTMIDVIERTANEVFIPLTVGGGINSVEDVRQILRAGADKVSVNTAAVKNPEFIREASN 122 Query: 118 RFGADALVLALDVRIDEQGN-----------------KQVAVSGWQENSGVSLEQLVETY 160 FG+ +V A+D + + +V + G +E +G+ Q + Sbjct: 123 IFGSQCIVTAIDCKRNLDVENNQDKTILELEDGTLAWYEVVIYGGREPTGLDTVQWAKKV 182 Query: 161 LPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGV 219 +G +L T ++RDGT G ++ + +++ + +SGG+G+ + + Sbjct: 183 EELGSGEILLTSMNRDGTYDGFDIPITKKLSEEL-DIPIIASGGVGNPEHMYKGFVDGKA 241 Query: 220 RGVIVGRALLEGKFTVKEAIACWQ 243 + G++TV++ + Sbjct: 242 DAGLAASIFHFGEYTVRDVKEALR 265 >UniRef50_A3CTR9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Methanomicrobiales RepID=HIS4_METMJ Length = 239 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 82/242 (33%), Positives = 125/242 (51%), Gaps = 8/242 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D++DG V+L QG YG DP + +GA+ LH+V+L GA A++ Sbjct: 3 IYPAVDILDGRCVQLVQGRPEAATVYG-DPAAWAHRWLDEGADGLHVVNLDGAFGRARKN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ ++GGG+RS ED A L+AGV RV+V + AV+ +M++ E FG Sbjct: 62 ADLIRAFTRETETFTELGGGIRSVEDAAGWLDAGVDRVIVSTQAVREPEMIRTLAEEFGG 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++ +D R +V + GW+ +G S E + +G +L T++ +G G Sbjct: 122 ERVMAGIDARA-----GEVMIEGWERPAG-SYLSWAERFESLGAGSLLYTNVDVEGLQQG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + E+ AR +V SGGI DVAALR G G ++G AL GK + EA+ Sbjct: 176 IAIEPVTELLAR-VKVPVVVSGGISSPGDVAALRDAGAAGAVLGSALYAGKVRLPEAMEA 234 Query: 242 WQ 243 Sbjct: 235 AH 236 >UniRef50_D0RQP1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RQP1_9RICK Length = 238 Score = 219 bits (558), Expect = 7e-56, Method: Composition-based stats. Identities = 74/241 (30%), Positives = 132/241 (54%), Gaps = 8/241 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL DG VRL +GD+ +Q Y P+ + + + +G E LH+VDL K Sbjct: 2 IIYPAIDLQDGKCVRLTKGDFEQQTVYSRSPIEQAKAFEDKGFEFLHVVDLDRTIHKEKS 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + IK ++ + VQVGGG+R+++ V +++ GV V+G+ AV D++ +++ Sbjct: 62 NLKTIKEIIQSTGLKVQVGGGLRTKDTVEEVIDLGVENAVMGTAAVNDPDLLIEISQKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + LDVR +K +A+ GW++ + +S +ET + LK ++ TDI++DG Sbjct: 121 KNKISVGLDVR-----DKMIALKGWKDQTEISCFDFLETIKNLPLKSIIFTDINKDGMKQ 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDD-VAALRGTGVRGVIVGRALLEGKFTVKEAI 239 G N+ ++ A + +SGG+ IDD + GV+VG+A+ +G + E + Sbjct: 176 GINIDDTLKM-AESSNIPVTASGGVSSIDDIKLIKSKKKISGVVVGKAIYDGLIDLNELV 234 Query: 240 A 240 Sbjct: 235 K 235 >UniRef50_B9DIP1 Imidazole glycerol phosphate synthase subunit hisF n=224 Tax=Bacteria RepID=HIS6_STACT Length = 254 Score = 218 bits (556), Expect = 1e-55, Method: Composition-based stats. Identities = 59/245 (24%), Positives = 120/245 (48%), Gaps = 6/245 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ Q + RD G DP+ Y A+ A+ L +D++ ++ + Sbjct: 6 IIPCLDVKDGRVVKGVQ--FKGLRDIG-DPVALAAYYNAELADELVFLDISRTENGHQMM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + + +P+ +GGG+ S +D++ LL+ G +V + S+A+++ +VK E+FG+ Sbjct: 63 LDIIEETASKLFIPLTIGGGISSTDDISTLLKHGADKVSLNSSALRNPSLVKEASEKFGS 122 Query: 122 DALVLALDVR-IDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +A+D + DE+ + G ++ + + + V +G +L T + DG Sbjct: 123 QCICIAVDAKWEDERNDWFCYTHGGKQPTDIRVLDWVRQVEYLGAGELLVTSMDYDGVKQ 182 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAI 239 G + L ++ + +SGG G+ L + T V + + + T+ Sbjct: 183 GFDHQLLNQI-NTVVSIPVIASGGGGNAQHFVDLFQQTNVSAGLAASIFHDKETTIGAVK 241 Query: 240 ACWQN 244 ++ Sbjct: 242 TYLKD 246 >UniRef50_C6Y3G6 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=2 Tax=Pedobacter RepID=C6Y3G6_PEDHD Length = 249 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 83/244 (34%), Positives = 141/244 (57%), Gaps = 11/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++DG VVRL +GDY ++ Y ++ Y + G E +H++DL GAK Q Sbjct: 3 IIPAIDILDGKVVRLTEGDYNQKTVYDVSIAEMIETYRSNGTEFIHIIDLNGAKGDFSNQ 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG- 120 L + ++ ++ VQ GGG+R+ + V LL+AG+ RV+VG+ A+ + D ++ + G Sbjct: 63 KALFE-VIKKTDMRVQYGGGIRTIKQVTDLLDAGIHRVIVGTQAITNPDFLQELSKEVGK 121 Query: 121 ----ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 A+ +V+A+DV ++ + SGW E+S + L V+ L +G LCTDI++D Sbjct: 122 KYDYANRIVIAIDV-----LDEVIKYSGWMESSPIKLMDYVDKCLQLGFFRFLCTDINKD 176 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G L G+ V LY+++ P + +SGG+ + D+ L +R V+VG+A+ E + T+ Sbjct: 177 GKLGGAAVELYKKLLEHSPFIKLIASGGVSSMKDIEELDKYDIRSVVVGKAIYENRITID 236 Query: 237 EAIA 240 + Sbjct: 237 QIKE 240 >UniRef50_A7FU80 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=104 Tax=Bacteria RepID=HIS4_CLOB1 Length = 242 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 74/243 (30%), Positives = 142/243 (58%), Gaps = 7/243 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+PA+DL +G +RL+QGD+ + DP+ + GAE +H+VDL GA + Sbjct: 2 IILPAIDLKEGKCIRLYQGDFKASKVVAEDPIEVALKFKENGAEYIHIVDLDGALTGEIK 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +I +++ +N+PV++GGG+R+ + L+ AG+ RV++G+ A+ ++ +V+ +++ Sbjct: 62 NLSIISSIIKTINIPVELGGGIRNLNTIDMLIGAGIERVILGTAALNNRGLVEEAVKKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + + +D + N++VA++GW S ++ + +G+++++ TDIS+DGTL Sbjct: 121 DEKIAIGIDAK-----NEKVAINGWLNVSSINYIDFAKEMEKIGVRNIIFTDISKDGTLK 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G N+ E++ +SGGI DI+D+ ++ V G IVG+A+ G + EAI Sbjct: 176 GPNLKQLEKLNESI-NCNVIASGGIKDIEDLKGIKEMDVYGAIVGKAIYSGNINLNEAIK 234 Query: 241 CWQ 243 Sbjct: 235 IIN 237 >UniRef50_B0T799 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Caulobacter RepID=HIS4_CAUSK Length = 241 Score = 216 bits (552), Expect = 4e-55, Method: Composition-based stats. Identities = 83/242 (34%), Positives = 133/242 (54%), Gaps = 10/242 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL DG VRL GD K + N P + + + G LH+VDL GA + Sbjct: 2 ILYPAIDLKDGQCVRLLHGDMEKATVFNNSPADQAERFVRDGFSWLHVVDLNGAIEGKSV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++++ +++PVQ+GGG+R+ E V A +EAGV+RV++G+ AV D+V+ R Sbjct: 62 NTAAVQSILESISIPVQLGGGIRTLEGVEAWIEAGVSRVILGTVAVHDPDLVRKAA-RLW 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +A+DVR + +VAV GW S + L + + VG+ ++ TDISRDG L Sbjct: 121 PEQIAVAVDVR-----DGKVAVDGWTGLSDLDAITLGKRFEDVGVAALIVTDISRDGALT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG---TGVRGVIVGRALLEGKFTVKE 237 G NV E+ A + +SGG+ + D+ L+ + G I+GR+L G E Sbjct: 176 GVNVEGVGEL-ADAVSIPVIASGGVASVADIERLKARPGVEIAGAILGRSLYAGTIRPAE 234 Query: 238 AI 239 A+ Sbjct: 235 AL 236 >UniRef50_D2Q1W2 Bifunctional HisA/TrpF protein n=2 Tax=Actinomycetales RepID=D2Q1W2_9ACTO Length = 256 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 85/246 (34%), Positives = 134/246 (54%), Gaps = 13/246 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+D+ DG VRL QG+ G + YG DPL + GAE +HLVDL A Sbjct: 17 VLLPAVDVADGQAVRLVQGEAGSETSYG-DPLAAATAWQEAGAEWIHLVDLDAAF-GRGS 74 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L+ + ++V V++ GG+R +E + A L G RV +G+ A++ + + +G Sbjct: 75 NRELLADVTGRLDVQVELSGGIRDDESLEAALATGARRVNIGTAALEDPEWCDRVIQTYG 134 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 D + + LDVR + +A GW + G L +++E G + + TD+++DG L Sbjct: 135 -DRVAIGLDVR-----GRTLAARGWTKEGG-DLYEVLERLERAGCERYVVTDVTKDGMLQ 187 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N+ LY ++CAR +SGG+ +DD+ AL GV GVIVG+AL G FT+ E Sbjct: 188 GPNLDLYRDLCAR-TAKPIVASGGVSSLDDLRALATLVPDGVEGVIVGKALYAGAFTLTE 246 Query: 238 AIACWQ 243 A+ + Sbjct: 247 ALELTR 252 >UniRef50_B1YL10 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sibiricum 255-15 RepID=B1YL10_EXIS2 Length = 234 Score = 215 bits (549), Expect = 8e-55, Method: Composition-based stats. Identities = 86/241 (35%), Positives = 138/241 (57%), Gaps = 9/241 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL+ G VRL QGD+ +Q +G D L + + GA +HL+DL GAK Sbjct: 3 LYPAIDLMSGQAVRLKQGDFQQQTFFG-DALTIARRFKEDGATAIHLIDLDGAKAGEPLH 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + LI + + V+ GGGVR+ E V A + AG+ R+++G+ A++ + +++ ER G Sbjct: 62 LSLIADIKKETGLFVEAGGGVRNIETVEAYVGAGIDRILIGTVALEDEALLEQMIERAG- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D L +ALD + + V GW E S +LE+ +E + G+K L TDISRDG + G Sbjct: 121 DKLAVALDAK-----DGIVQTRGWLEASDWTLERAIEHLIQKGIKTFLYTDISRDGMMQG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 +V + + + V +SGG+ ++DVA L+ G+ G ++GRALL+G ++KE + Sbjct: 176 PDVDGLDLL--KRDGVELIASGGVTTVEDVARLKEIGMDGAVIGRALLDGSLSLKEVLRV 233 Query: 242 W 242 Sbjct: 234 C 234 Score = 42.1 bits (98), Expect = 0.016, Method: Composition-based stats. Identities = 15/93 (16%), Positives = 38/93 (40%), Gaps = 1/93 (1%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 + + G + D+ ++SL ++ + ++ GG+ +I+ V Sbjct: 30 DALTIARRFKEDGATAIHLIDLDGAKAGEPLHLSLIADIKKE-TGLFVEAGGGVRNIETV 88 Query: 212 AALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 A G G+ +++G LE + +++ I + Sbjct: 89 EAYVGAGIDRILIGTVALEDEALLEQMIERAGD 121 >UniRef50_Q056S8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=4 Tax=Leptospira RepID=HIS4_LEPBL Length = 241 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 84/246 (34%), Positives = 143/246 (58%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+DL D VRL +G+Y +++ Y ++P + +A GA +LHLVDL GA++ Sbjct: 2 IIIPAIDLFDNCAVRLFKGNYKEKKIYSSEPWKLAEGFAKNGATLLHLVDLNGARNQLGI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I + ++ VQ+GGG+R +E +A + G+ R ++G+ AV D++K + + Sbjct: 62 NEDSILKIRKTTSLKVQLGGGIRDKEKLAYYDKIGIDRFILGTAAVTDPDLLKFALDNYE 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +V+A+D + V ++GW+++SGV L++ G++H++ TDI++DGTLA Sbjct: 122 KERVVVAVDA-----IDGIVKIAGWEKDSGVRYRDLMDRLAKAGIEHIVFTDIAQDGTLA 176 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG----VRGVIVGRALLEGKFTVK 236 G N+ Y+E+ YP +SGGI + D+ L + GVI G+AL EGK + Sbjct: 177 GPNLKAYQEILNSYP-FQVIASGGISSLKDLMDLSSLKTKIPLYGVITGKALYEGKLDLA 235 Query: 237 EAIACW 242 +AI+ Sbjct: 236 KAISSI 241 >UniRef50_Q4JW54 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=144 Tax=Bacteria RepID=HIS4_CORJK Length = 258 Score = 215 bits (547), Expect = 1e-54, Method: Composition-based stats. Identities = 85/245 (34%), Positives = 129/245 (52%), Gaps = 9/245 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D+ DG VRL QG G + YG P+ + GAE +HLVDL A Sbjct: 12 LLPAVDVADGQAVRLVQGAAGTETSYGA-PIEAALAWQNAGAEWIHLVDLDAAF-GRGSN 69 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L+K + ++V V++ GG+R +E + L G RV +G+ A++ + + R+G Sbjct: 70 FELLKEVTGQLDVNVELSGGIRDDESLERALSTGCRRVNIGTAALEDPEWCESVISRYG- 128 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + LD R G ++ GW + G L +++E G+ ++ TD+SRDG L G Sbjct: 129 DKVAIGLDTREV-DGEWRLRGRGWTSDGG-ELWEVLERLDSQGVSRLVVTDVSRDGMLNG 186 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKEA 238 N+ L EV A +SGGI +DD+ AL GV IVG+AL GKFT++EA Sbjct: 187 PNIDLLREVAA-ATDAPVVASGGISSLDDIRALAAVVHEGVDSAIVGKALYAGKFTLEEA 245 Query: 239 IACWQ 243 + Q Sbjct: 246 LEAAQ 250 >UniRef50_Q5NMD5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Zymomonas mobilis RepID=HIS4_ZYMMO Length = 250 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 79/246 (32%), Positives = 126/246 (51%), Gaps = 10/246 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I PA+DL +G VVRL +GD + Y +DP R + + GA LH+VDL GA Sbjct: 6 IIFPAIDLKEGHVVRLSEGDMDRATIYDDDPAARARQFYEAGARYLHVVDLDGAFAGHAM 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +V +++GGG+R + L G++RVV+G+ A ++ D+VK +++ Sbjct: 66 NAAAVDAIVKAFPGTIELGGGIRDMNAIDGWLSRGISRVVIGTAAFENPDLVKEAAQKYP 125 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+A+D R + V GW E S +S+ + E + G+ +L TD+ RDG Sbjct: 126 GQ-IVVAVDAR-----DGMVTTKGWAEQSEISVTDMAERFADAGVVALLYTDVGRDGLKK 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKE 237 G N A + +SGG+ DI D+ L G+ GVI GRA+ +G +K Sbjct: 180 GCNSEATLA-LAAATDIPVIASGGVKDIGDIELLARHTKDGIEGVICGRAIYDGSLDLKA 238 Query: 238 AIACWQ 243 A+A + Sbjct: 239 ALAIAR 244 >UniRef50_A8ZUC6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Proteobacteria RepID=HIS4_DESOH Length = 251 Score = 213 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 93/245 (37%), Positives = 132/245 (53%), Gaps = 10/245 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IPA+D+ G VRL QGD + + +DP + +A GAE++H+VDL GA + + R Sbjct: 2 MVIPAVDIKGGKCVRLLQGDMNAETVFSDDPGAMAERWAEAGAELIHVVDLDGAIEKSPR 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + I L+ V VPVQVGGG+R + V + GVAR+V+GS AV D+V F Sbjct: 62 NLKAISALIRRVGVPVQVGGGIREIDTVKMYADLGVARIVIGSAAVNHPDLVTAACREFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +VL +D R + +VA GW + ++ L + G+ + TDI RDG Sbjct: 122 G-RIVLGIDAR-----DGRVATEGWTSTTDIAAADLAARFEGCGVAAINFTDIHRDGMRT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL---RGTGVRGVIVGRALLEGKFTVKE 237 G N+ E AR + +SGG+ IDD+ AL + GV GVI GRAL +G + E Sbjct: 176 GPNIPAIEAF-ARATAIPVVASGGVSTIDDIQALLGIQEFGVTGVITGRALYDGTLDLAE 234 Query: 238 AIACW 242 AIA Sbjct: 235 AIAVA 239 >UniRef50_Q67KH9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_SYMTH Length = 249 Score = 213 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 84/247 (34%), Positives = 127/247 (51%), Gaps = 14/247 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+DL DG VVRL QG + YG DP+ +A GA +H+VDL GA + Sbjct: 5 LYPAIDLKDGQVVRLRQGRMDEATVYGVDPVRIAARWAEAGARWIHVVDLDGALRGRPQN 64 Query: 62 IPLIKTLVAG-----VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 ++ +V V VQ+GGG+R+ E + A L GV+R ++G++A++ D+ Sbjct: 65 AAAVRAIVEALRQRHPGVRVQLGGGLRTLEALEAALALGVSRAIIGTSALEG-DVAARAV 123 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 RFG D + +++D R VA GW E + V L VG++ V+ TDI+ D Sbjct: 124 ARFGPDRVAVSIDAR-----GGFVAARGWVEVTRVRAVDLAVRMREVGVRTVVYTDIATD 178 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTV 235 G L G N + E + + +SGGI ++D+ L GV G I+GRAL G + Sbjct: 179 GMLTGPNFAELEMMGR--TGLDVIASGGISSLEDIRRLTEIPGVAGAIIGRALYTGAVDL 236 Query: 236 KEAIACW 242 EA++ Sbjct: 237 AEALSLC 243 >UniRef50_C7RAI6 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI6_KANKD Length = 265 Score = 211 bits (539), Expect = 1e-53, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 108/249 (43%), Gaps = 10/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ G VV+ ++ +D G DP+ Y QGA+ + +D+ + Sbjct: 9 VIVCLDVAHGRVVKGV--NFKGLQDMG-DPVELAIRYQEQGADEIIFLDIKATLEQRANA 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + +++P VGGG+ + DVA L AG +V + S AVK D+V + FG+ Sbjct: 66 LEVVTRVAENLSIPFTVGGGLNTYADVAQFLNAGADKVALNSAAVKHPDLVDEIAKGFGS 125 Query: 122 DALVLALDV------RIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +V+A+D+ + +V ++G + ++ Q + G +L T + R Sbjct: 126 QCVVVAVDLNQEQDQKTQGSSEYEVYINGGHTLTDLNAMQWLTEIEQRGAGEILLTAMHR 185 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGT G + L +V + + +SGG G + G+FTV Sbjct: 186 DGTGFGFDNELMSQVSKKL-GIQVIASGGASKPAHFTDTFLAGSDAALAAGMFHRGEFTV 244 Query: 236 KEAIACWQN 244 + N Sbjct: 245 GQVKQELLN 253 >UniRef50_C0RFX3 Imidazole glycerol phosphate synthase subunit hisF n=420 Tax=cellular organisms RepID=HIS6_BRUMB Length = 261 Score = 211 bits (539), Expect = 1e-53, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 123/249 (49%), Gaps = 9/249 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP LD+ DG VV+ ++ D G DP+ + Y A GA+ L +D+T + D + Sbjct: 7 VIPCLDVKDGRVVKGV--NFVDLIDAG-DPVEAARAYDAAGADELCFLDITASSDNRETI 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ +P+ VGGGVR D+ LL AG +V + + AVK+ + V ++FG Sbjct: 64 FDVVARTAEQCFMPLTVGGGVRQVADIRKLLLAGADKVSINTAAVKNPEFVAEAADKFGN 123 Query: 122 DALVLALDVRI----DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+A+D + E + ++ G ++ +G+ + + + +G +L T + RDG Sbjct: 124 QCIVVAIDAKKVSGAGENDHWEIFTHGGRQPTGIDAVEFAQKVVDLGAGEILLTSMDRDG 183 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVK 236 T AG +V+L V A + +SGG+G +D + A +R V+ G +T+ Sbjct: 184 TKAGYDVALTRAV-ADSVRAPVIASGGVGTLDHLVAGIRDGHATAVLAASIFHFGTYTIG 242 Query: 237 EAIACWQNA 245 EA A Sbjct: 243 EAKRYMAEA 251 >UniRef50_B6YWA8 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=7 Tax=cellular organisms RepID=HIS4_THEON Length = 229 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 75/242 (30%), Positives = 121/242 (50%), Gaps = 16/242 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL+ G VRL++G K + YG DP+ + + +H+VDL GA + Sbjct: 3 IYPAIDLMGGKAVRLYRGQKEKVKVYG-DPVEIASRFTEL-VDKIHVVDLDGAFTGKPQN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++K ++ + VQVGGG RS E +A E G V++G+ A + ++ + F Sbjct: 61 LDVVKEIIEETGLKVQVGGGFRSYESIAKAYEIGAENVIIGTKAF-DLEFLEKITDNFDG 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++LD R ++AV GW E S + + + E + + T I RDGTL G Sbjct: 120 --ITVSLDAR-----GGKIAVKGWLEESSLKVGEAYEMLREY-VDRFIYTSIERDGTLTG 171 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 E + + F +GG+ +DDV LR G G IVG+AL E + ++KE + Sbjct: 172 -----IESIERFWKDEEFIYAGGVSSVDDVLKLRRVGFSGAIVGKALYESEVSLKELLEV 226 Query: 242 WQ 243 + Sbjct: 227 LE 228 >UniRef50_C8WPG6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Coriobacteriaceae RepID=C8WPG6_EGGLE Length = 257 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 83/243 (34%), Positives = 137/243 (56%), Gaps = 9/243 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D++ G VRL +GDY + Y +DP + Q + QGA LH+VDL GA+ Sbjct: 3 LLPAIDILGGKAVRLAKGDYDRVTVYHDDPAAQAQLFEEQGATWLHVVDLDGARSGIPEN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ ++ + V+VGGGVRS + +A L +AGV+RVV+G++ V D + ++G Sbjct: 63 IAIVERIMRKTLLKVEVGGGVRSLDTIARLADAGVSRVVLGTSLVADPDFAEAAIAQYG- 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 L +D + +VAV+GW+E +GV+ E+L +G +H++ TDI+RDG G Sbjct: 122 KLLCAGIDAK-----GGEVAVAGWREGAGVAAEELARDMSALGFRHLVYTDIARDGMQTG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT--GVRGVIVGRALLEGKFTVKEAI 239 + Y + + +SGG+ +DD+ L + GVI GRA+ EG +V+E + Sbjct: 177 IEAAAYVRMAEAFGH-PVIASGGVAGVDDIVRLGEVAGSIEGVIAGRAVYEGALSVQEGV 235 Query: 240 ACW 242 Sbjct: 236 RAC 238 >UniRef50_Q8DJN7 Imidazole glycerol phosphate synthase subunit hisF n=55 Tax=cellular organisms RepID=HIS6_THEEB Length = 281 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 71/248 (28%), Positives = 115/248 (46%), Gaps = 10/248 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ G VV+ ++ RD G DP+ Q Y A GA+ L +D+T + Sbjct: 7 ILPCLDVKAGRVVKGV--NFVNLRDAG-DPVELAQAYNAAGADELVFLDITATHEERNIL 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V +P+ VGGG++S + LL AG +V + S AV+ D+V +RFGA Sbjct: 64 IDVVYRTADQVFIPLTVGGGIQSLTMIKDLLRAGADKVSLNSAAVRQPDLVNQASDRFGA 123 Query: 122 DALVLALDVRIDEQG-----NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +V+A+D R + QV V G +E +G+ G +L T + D Sbjct: 124 QCIVVAIDARREPDCAPDQPRWQVYVRGGREATGLDAVAWAVEMAKRGAGELLVTSMDAD 183 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTV 235 GT AG ++ L + R ++ +SGG G + + AL ++ L G+ T+ Sbjct: 184 GTQAGYDLELTRAIAER-VEIPVIASGGAGTCEHIRAALVEGKAEAALLASLLHYGQLTI 242 Query: 236 KEAIACWQ 243 + Sbjct: 243 AQIKGYLH 250 >UniRef50_A7H8C3 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Bacteria RepID=HIS4_ANADF Length = 238 Score = 210 bits (536), Expect = 2e-53, Method: Composition-based stats. Identities = 76/235 (32%), Positives = 128/235 (54%), Gaps = 7/235 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL+ G VRL +GD+ + Y P + +++A GA +LH+VDL GAK Sbjct: 2 LVIPAIDLMGGEAVRLEKGDFATKTVYARHPAEKAEEFARAGATLLHVVDLDGAKAGWPV 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + ++ + + V++GGG+RS D+ +L GV VV+G+ AV+ +V+ +RF Sbjct: 62 NLDAVRAICEVPGIEVELGGGLRSLPDIEKVLALGVRYVVLGTAAVERLGLVEQACQRFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + +D R N +V ++GW E +G++ + G+ V TD++RDG Sbjct: 122 GQ-VRAGIDAR-----NGEVKIAGWLEGTGLAAVDVARKVKGAGVGLVEYTDVARDGMFT 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 G + + + A + +SGG+ +DDV A R G+ GVIVG+AL E + + Sbjct: 176 GVDAAGAARIQAEA-GIPVVASGGVASLDDVTACRAAGLAGVIVGKALYERRIDL 229 >UniRef50_A1ZVN4 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZVN4_9SPHI Length = 246 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 69/237 (29%), Positives = 127/237 (53%), Gaps = 5/237 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P++ ++ G VVR +GD + + Y +PL ++ G + LHLVDL GAK Sbjct: 4 IVPSIAILGGKVVRTIKGDIDQVQVYDTNPLDLALEFENNGIKHLHLVDLDGAKARQIVN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ L + + + GG+ ++D+ E G V + AV ++ W +G Sbjct: 64 YNILEMLASYTQLEIDYTGGITRDDDIRTAFECGAKHVTAATVAVHEREKFLSWVITYGG 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++LA D + V GW++N+G+ L + +++Y G++ V T+I R+GTL G Sbjct: 124 NKVILAADA-----LDGVVLTKGWRKNTGIDLVEHIKSYHERGVRFVKTTEIGRNGTLEG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 N Y+++ +P++ +SGGI I+D+ L GV GVI+G++ +G+ +K+ Sbjct: 179 PNFDTYKKLRTEFPELQILASGGIRSIEDIEQLDALGVAGVIIGKSYYDGQIKLKDL 235 Score = 47.1 bits (111), Expect = 5e-04, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 48/120 (40%), Gaps = 6/120 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I A D +DG V L +G G D + ++ Y +G + ++ Sbjct: 126 VILAADALDGVV--LTKGWRKNT---GIDLVEHIKSYHERGVRFVKTTEIGRNGTLEGPN 180 Query: 62 IPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 K L + + GG+RS ED+ L GVA V++G + Q +K + G Sbjct: 181 FDTYKKLRTEFPELQILASGGIRSIEDIEQLDALGVAGVIIGKSYYDGQIKLKDLQKFIG 240 >UniRef50_C8WUX9 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WUX9_ALIAD Length = 252 Score = 210 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 92/244 (37%), Positives = 131/244 (53%), Gaps = 11/244 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D++ G VVRL QGDY + Y DP GA LH+VDL A+ Sbjct: 8 VYPAIDILGGEVVRLRQGDYQQVTRYDGDPAGVAGRLCDAGARFLHVVDLDAARSGQSDN 67 Query: 62 IPLIKTLVAGV---NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 ++ +V VQVGGG+R+++ +A LEAGVARVV+G+ AV+ ++V W + Sbjct: 68 ERAVRAIVETAASYGAAVQVGGGIRTKDAIARWLEAGVARVVIGT-AVRQVEVVAEWAQE 126 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 FG LV LD R ++AVSGW E + S+ L VGL L TD+ RDGT Sbjct: 127 FGGHRLVAGLDGRK-----GRLAVSGWLEETEWSIFDLARELAKVGLVQALVTDVERDGT 181 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G N+ L + + + +SGGIG IDDV A+R G+ G ++G+AL +G+ + E Sbjct: 182 GEGPNLDL--ALGVQETGLFAIASGGIGSIDDVVAVRRAGLAGAVIGKALHDGRIHLGEL 239 Query: 239 IACW 242 Sbjct: 240 FQRL 243 >UniRef50_A8M910 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M910_CALMQ Length = 254 Score = 209 bits (532), Expect = 7e-53, Method: Composition-based stats. Identities = 61/241 (25%), Positives = 107/241 (44%), Gaps = 6/241 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP +D+ VV+ ++ R G DP+ Y +GA+ L L+D+T Sbjct: 11 IIPCMDVDADIVVKGV--NFEGLRVMG-DPVELASRYEEEGADELFLLDITATVQGRSTF 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + A V++P+ VGGG+R ED A +AG +V + + AVK +V +G+ Sbjct: 68 LETVRNVAAAVSIPLGVGGGIRGMEDADAAFKAGADKVSINTAAVKDPSIVAKLSREYGS 127 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V+A+D R +V + G + + ++ T +G +L T I DGT AG Sbjct: 128 QSVVVAIDTRRINN-EWRVFIMGGRRETLLNAVDWARTVEELGAGELLVTSIDADGTRAG 186 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++ LY + A + +SGG G+ + + G + A Sbjct: 187 YDIELYRRL-ADAVNIPVIASGGAGEPSHFLEVLKY-ADAALAASVFHMGVINISILKAY 244 Query: 242 W 242 Sbjct: 245 L 245 >UniRef50_D1B860 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B860_THEAS Length = 232 Score = 208 bits (531), Expect = 9e-53, Method: Composition-based stats. Identities = 80/239 (33%), Positives = 121/239 (50%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+DL G VVRL G + Y P +A G H+VDL GAK Sbjct: 3 IYPAVDLYGGKVVRLTGGRFQDATVYPTSPGEMALLFAQAGVRWAHVVDLEGAKTGRPVH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ + VQ GGG+RS + V L AG RV++GS V FG Sbjct: 63 LWALEAFAGA-GLKVQFGGGIRSIQSVRDALSAGATRVMMGSALFDRSVDVVEAHRLFGP 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A++ A+D R +V+V GW + + + +++ +E VG L TD RDGTL+G Sbjct: 122 -AILPAVDHR-----GWRVSVKGWTQGTDIPVDRALENLSRVGFSLFLVTDGDRDGTLSG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ Y ++CARY ++GGIG++ + LR G G ++G+AL EG +++EA+ Sbjct: 176 PDLEGYRKICARYG---IIAAGGIGELGHLRGLRNAGAAGAVLGKALYEGAISIEEAMR 231 >UniRef50_Q7N8D1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2 n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=HIS42_PHOLL Length = 258 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 79/252 (31%), Positives = 129/252 (51%), Gaps = 14/252 (5%) Query: 2 IIPALDLIDGTV------VRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 I P++D++DG +RL +G+ R P + GA+ +H+VDL A Sbjct: 9 IFPSVDIVDGIAMTSNSAIRLTRGESSTLRRPLGTPAEVALAWQNAGAKWIHVVDLDAA- 67 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 LI ++A V++ VQV GG+R E + +L G RV +G+ A+++ D Sbjct: 68 SGRGSNSHLIADVLAAVDINVQVCGGIRDETILRKVLATGCQRVNLGTAALENPDWCAQA 127 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +G D + +ALDV+ +G Q+A GW S +L L+E G + + TD+ R Sbjct: 128 IAEYG-DKIAIALDVKSTSEG-YQLATHGW-NVSKGNLWDLLERLDKQGCQRYVVTDVER 184 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGK 232 G ++ N +L +EVCA+ + GG+ +DD+ AL GV G I+G+AL GK Sbjct: 185 GGMMSSPNFTLLQEVCAKTSS-PVIAGGGVSSLDDLRALADLSTIGVEGAILGQALHIGK 243 Query: 233 FTVKEAIACWQN 244 +++A+A Q+ Sbjct: 244 VPLEDALAATQS 255 >UniRef50_B4U8M5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Hydrogenobaculum sp. Y04AAS1 RepID=B4U8M5_HYDS0 Length = 234 Score = 208 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 76/236 (32%), Positives = 131/236 (55%), Gaps = 9/236 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ DG VVRL +G + + Y +P+ + + + G +H+VDL GAK + Sbjct: 4 FIIPAIDIKDGAVVRLKEGKFENVKVYRQNPIDQFKLFVDLGFTRIHIVDLDGAKVGIPK 63 Query: 61 QIPLIKT-LVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + L++ L + V++GGG+RS E AL E G ++VG+ AVK ++ E + Sbjct: 64 NLKLLEDMLKQKNDAKVEIGGGIRSLETAKALFEIGADYIIVGTLAVKDKEEFIRLLELY 123 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 D ++L++D + N +VA+ GW+E S +S + Y ++ L T+I+ DGTL Sbjct: 124 -KDRIILSVDAK-----NGKVAIGGWEEESSISPCDMARIYDNYPIESYLYTNINIDGTL 177 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 G +++ Y++ + +SGG+ ++DV L+ V GV+VG+A+ E K + Sbjct: 178 TGVDINPYKDF-KKCTTKPIIASGGVASLEDVIKLKTV-VNGVVVGKAIYENKIDI 231 >UniRef50_C4ZLR4 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Thauera sp. MZ1T RepID=C4ZLR4_THASP Length = 226 Score = 206 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 65/243 (26%), Positives = 110/243 (45%), Gaps = 31/243 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ G VV+ ++ + RD G DP+ + Y Q Sbjct: 6 IIPCLDVKSGRVVKGV--NFVELRDAG-DPVEIARRYDEQ-------------------- 42 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + V +P+ VGGGVR EDV LL AG +V + + AV + +V + G+ Sbjct: 43 ------VAEQVFIPLTVGGGVRVVEDVRRLLNAGADKVSMNTAAVNNPQLVFEAASKVGS 96 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A+D + G +V G + N+G+ + +G +L T + RDGT +G Sbjct: 97 QCIVVAIDAKQTAPGKWEVFTHGGRNNTGLDAIEWARKVESLGAGEILLTSMDRDGTKSG 156 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKEAIA 240 +++L V + ++ +SGG+G ++ +A G V+ G+ TV+EA Sbjct: 157 FDLALTRAV-SDAVRIPVIASGGVGTLEHLAEGVSEGRADAVLAASIFHFGQHTVREAKE 215 Query: 241 CWQ 243 + Sbjct: 216 LMR 218 >UniRef50_P74106 Imidazole glycerol phosphate synthase subunit hisF n=67 Tax=Bacteria RepID=HIS6_SYNY3 Length = 261 Score = 206 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 69/246 (28%), Positives = 115/246 (46%), Gaps = 8/246 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ G VV+ ++ +D G DP+ + Y GA+ L +D+T + Sbjct: 7 ILPCLDVNAGRVVKGI--NFVDLQDAG-DPVELARAYNEAGADELVFLDITATHEQRDTI 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++ V +P+ VGGG+ + E + LL AG +V V S+AV+ D + +RFG Sbjct: 64 IDVVYRTAEEVFIPLTVGGGISTLEHIKNLLRAGADKVSVNSSAVRDPDFISRASDRFGR 123 Query: 122 DALVLALDVRIDEQGN---KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 +V+A+D R + V V G +EN+G+ E G +L T + DGT Sbjct: 124 QCIVVAIDARRRLDADNPGWDVYVRGGRENTGLDAIAWAEEVAKRGAGELLVTSMDGDGT 183 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTVKE 237 AG +++L + R ++ +SGG G+ V G ++ L G+ T+ E Sbjct: 184 QAGYDLALTAAIAER-VEIPVIASGGAGNCQHVYEAFTEGKAEAALLASLLHYGQLTIGE 242 Query: 238 AIACWQ 243 + Sbjct: 243 LKTFLE 248 >UniRef50_O29276 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Archaeoglobaceae RepID=HIS4_ARCFU Length = 238 Score = 206 bits (525), Expect = 5e-52, Method: Composition-based stats. Identities = 76/240 (31%), Positives = 122/240 (50%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IPA+DL DG VVRL QG + +P+ + + GA+VLH++DL+GA R Sbjct: 4 VIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAKVLHVIDLSGAFQGRLRH 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + VQVGGG+R L E GV RV+ G+ AV+ + ++ + +++ Sbjct: 64 EEIIAEIAKMAE--VQVGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKWKG 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +++A+D + +VAV GW+E ++ QL E Y + + L T+I +G ++G Sbjct: 122 -RVMVAIDSKK-----GRVAVKGWKEVVELTPVQLAELYDDLDVS-FLYTNIDVEGLVSG 174 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 EEV +GGI I+D+ + G GV++G AL K +EAI Sbjct: 175 IERERIEEVVKSLRN-PVYVAGGISSIEDIRFAKRVGAAGVVIGSALYTKKLKFEEAIKV 233 Score = 43.2 bits (101), Expect = 0.008, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 43/121 (35%), Gaps = 3/121 (2%) Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 ++ A+D++ + + + ++ + ++ +G K + I G G Sbjct: 3 RVIPAIDLKDGKVVRLRQGKEDEVTFEATNPIEVAKQWVEIGAK--VLHVIDLSGAFQGR 60 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACW 242 + E + Q GGI D L GV VI G +E ++E W Sbjct: 61 -LRHEEIIAEIAKMAEVQVGGGIRDFRVAERLFELGVDRVIFGTIAVERVEELREFAKKW 119 Query: 243 Q 243 + Sbjct: 120 K 120 >UniRef50_B1ZW12 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Opitutaceae RepID=HIS4_OPITP Length = 243 Score = 206 bits (524), Expect = 6e-52, Method: Composition-based stats. Identities = 78/237 (32%), Positives = 122/237 (51%), Gaps = 13/237 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ G VRL QG ++ Y +P + A G+E +H+VDL GA + Sbjct: 3 IYPAIDIKGGRCVRLTQGRAEQETIYAQNPADVAMQFRAAGSEWVHVVDLDGAFAGEPQN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ +V V + VQ GGG+R+ V L GV+RVV+G+ A +S+ V + FG Sbjct: 63 LAAVQAIV-AVGMKVQFGGGLRTRAAVERALALGVSRVVLGTRAAESESFVGELVQAFG- 120 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + + +D + N +VAV GW + +S L +G+ ++ TDI DG L G Sbjct: 121 DKIAVGIDAK-----NGKVAVKGWVATADLSTLVLARRMDTLGVATLIHTDIGTDGMLTG 175 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-----GVRGVIVGRALLEGKF 233 N++ E +C+ + +SGG+ DDV L + GVIVG+AL E + Sbjct: 176 PNLAAQEALCS-AVKSRVIASGGVSRRDDVVNLAKLAQRHANLDGVIVGKALYERRV 231 >UniRef50_Q1GHT0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1 n=15 Tax=Rhodobacterales RepID=HIS41_SILST Length = 247 Score = 206 bits (524), Expect = 8e-52, Method: Composition-based stats. Identities = 70/244 (28%), Positives = 116/244 (47%), Gaps = 9/244 (3%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI P ++L+DG V L +G+ + DP+ + +A GAE +HL D A Sbjct: 2 MIYPTMELLDGRCVTLDKGNLDAPMIWHVDPVETAKGFAEAGAEWMHLTDFN-ALQGDSS 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L++ L+ +P+Q+GGG+RS E +E GV RVV+G+ A V + + Sbjct: 61 NQDLVEELIRTAGLPIQLGGGIRSREQAEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYP 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +VLA+DV QV GW+++ + E V+ + +L TDI D + Sbjct: 121 DQ-VVLAVDVWQ-----GQVMTEGWRKSGAWTPEAFVKAFGNAPFAGILVTDIDSDMSDL 174 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAI 239 + + L + + +SG + DD++ L+ + G +VGRAL T++EA+ Sbjct: 175 DAQLGLISGLAEQA-HSPVIASGVVRSKDDISRLKYLPNISGALVGRALFNKTITLEEAM 233 Query: 240 ACWQ 243 Q Sbjct: 234 ETAQ 237 Score = 40.5 bits (94), Expect = 0.052, Method: Composition-based stats. Identities = 18/94 (19%), Positives = 32/94 (34%), Gaps = 2/94 (2%) Query: 151 VSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 V + + + G + + TD + + N L EE+ + Q GGI + Sbjct: 30 VDPVETAKGFAEAGAEWMHLTDFNALQGDSS-NQDLVEELIRTA-GLPIQLGGGIRSREQ 87 Query: 211 VAALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 GV V++G V E + + Sbjct: 88 AEFWIEKGVGRVVIGTMAAYDPAAVAELAKYYPD 121 >UniRef50_Q18JI3 Imidazole glycerol phosphate synthase subunit hisF n=36 Tax=cellular organisms RepID=HIS6_HALWD Length = 270 Score = 205 bits (521), Expect = 1e-51, Method: Composition-based stats. Identities = 51/259 (19%), Positives = 106/259 (40%), Gaps = 21/259 (8%) Query: 2 IIPALDLI----DGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 IIP +D+ V + G + +Y DP+ + Y GA+ +D+T + Sbjct: 6 IIPCIDVDLDEDGNPAV--YTGINFEDLEYTGDPVEMAKQYNMAGADEFVFLDITASAVG 63 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 + + + + + +P+ VGGG+R+ +D+ + L AG +V + + A+++ +++ Sbjct: 64 RETMLETVSRVADEIFIPLTVGGGIRTRDDIKSTLRAGADKVSINTAALETPELITTGAS 123 Query: 118 RFGADALVLALDVRIDEQGNK-------------QVAVSGWQENSGVSLEQLVETYLPVG 164 FG+ +V+++D R + V G +E +G+ + + V G Sbjct: 124 AFGSQCIVISVDARRRFDEQGENYLSVDGESCWFECTVKGGREGTGIDVLEWVTEAETRG 183 Query: 165 LKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVI 223 + I DGT G ++ L VC +S G G D+ + G + Sbjct: 184 AGELFINSIDADGTQDGYDIPLTSAVC-DAVSTPVIASSGCGSPADMHEVFTEAGADAGL 242 Query: 224 VGRALLEGKFTVKEAIACW 242 G+++++ Sbjct: 243 AASIFHFGEYSIEATKEYL 261 Score = 39.8 bits (92), Expect = 0.074, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 36/108 (33%), Gaps = 5/108 (4%) Query: 17 HQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPV 76 +G G D L + + +GA L + + IPL + V+ PV Sbjct: 161 VKGGREGT---GIDVLEWVTEAETRGAGELFINSIDADGTQDGYDIPLTSAVCDAVSTPV 217 Query: 77 QVGGGVRSEEDVAALL-EAGVARVVVGSTAVKSQDMVKGWFERFGADA 123 G S D+ + EAG + ++ + + + + Sbjct: 218 IASSGCGSPADMHEVFTEAGADA-GLAASIFHFGEYSIEATKEYLDER 264 >UniRef50_B5YIB7 Imidazole glycerol phosphate synthase subunit hisF n=5 Tax=cellular organisms RepID=HIS6_THEYD Length = 278 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 116/269 (43%), Gaps = 31/269 (11%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ RD G DP+ Y + A+ L +D+T + + K Sbjct: 6 IIPCLDVKDGRVVKGV--NFLNLRDAG-DPVENALYYNEEEADELVFLDVTASHEKRKII 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ + V +P+ VGGG++S +D+ LL AG +V + +TAVK ++ RFG+ Sbjct: 63 IDVVERTASVVFMPLTVGGGIKSLDDIRDLLNAGADKVSINTTAVKDPYFIQKASTRFGS 122 Query: 122 DALVLALDVRI--------------------------DEQGNKQVAVSGWQENSGVSLEQ 155 +V+A+D + E ++ G + + Sbjct: 123 QCIVIAIDAKRVDKNFNPKAYPPESWFDDKELSDVLYKEDSRFVLSTHGGRLMRPIDAIA 182 Query: 156 LVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AAL 214 + G +L T + RDGT G ++ L + + + +SGG G ++ + A Sbjct: 183 WAKKMEEFGAGEILLTSMDRDGTKEGYDIELTRAI-SEAVSIPVIASGGAGTLEHLYEAF 241 Query: 215 RGTGVRGVIVGRALLEGKFTVKEAIACWQ 243 + +++++EA + Sbjct: 242 AYAKADAALAASIFHFREYSIREAKEFLR 270 >UniRef50_A1KJ21 Imidazole glycerol phosphate synthase subunit hisF n=76 Tax=Bacteria RepID=HIS6_MYCBP Length = 267 Score = 204 bits (519), Expect = 2e-51, Method: Composition-based stats. Identities = 69/247 (27%), Positives = 116/247 (46%), Gaps = 10/247 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP LD+ DG VV+ ++ RD G DP+ Y A+GA+ L +D+T + Sbjct: 17 VIPCLDVDDGRVVKGV--NFENLRDAG-DPVELAAVYDAEGADELTFLDVTASSSGRATM 73 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ V +P+ VGGGVR+ DV +LL AG +V V + A+ D++ +FG+ Sbjct: 74 LEVVRRTAEQVFIPLTVGGGVRTVADVDSLLRAGADKVAVNTAAIACLDLLADMARQFGS 133 Query: 122 DALVLALDVRIDEQG------NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 +VL++D R G +V G + +G+ Q +G+ +L + Sbjct: 134 QCIVLSVDARTVPVGSAPTPSGWEVTTHGGRRGTGMDAVQWAARGADLGVGEILLNSMDA 193 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 DGT AG +++L V A V +SGG G ++ A G V+ + T+ Sbjct: 194 DGTKAGFDLALLRAVRA-AVTVPVIASGGAGAVEHFAPAVAAGADAVLAASVFHFRELTI 252 Query: 236 KEAIACW 242 + A Sbjct: 253 GQVKAAL 259 >UniRef50_Q0IDQ9 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Synechococcus sp. CC9311 RepID=Q0IDQ9_SYNS3 Length = 255 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 60/244 (24%), Positives = 115/244 (47%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ GT+++ Q R G DP+ + Y+ GA+ L +D+ + Sbjct: 6 IIPRLDIKSGTLIKGVQ--MEGWRKVG-DPILAAKRYSEYGADELLFMDVVASLYERNTL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +++ + + V +PV VGGG+R +DV LL G +V V + A+ +++ +R+G+ Sbjct: 63 HEIVEQVCSNVFIPVTVGGGIRKIKDVETLLSRGADKVSVNTGALLKPELINEISDRYGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A VL ++ + + + + SG + + V+ G ++ T I +DG G Sbjct: 123 QATVLTVECLKCGEKSWEALTDNGRNRSGREVIEWVKEAENRGAGEIVLTSIDQDGRGYG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ L ++ ++ + +SGG G + L + T V G + +AL K + E Sbjct: 183 FDIDLV-DIVSQAVNIPIIASGGFGKPSHIVELIKSTDVSGAAIAQALHWEKVSFSEIRD 241 Query: 241 CWQN 244 ++ Sbjct: 242 SLRD 245 >UniRef50_D0CY30 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=1 Tax=Silicibacter lacuscaerulensis ITI-1157 RepID=D0CY30_9RHOB Length = 282 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 70/245 (28%), Positives = 115/245 (46%), Gaps = 9/245 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + P ++L +G V L +G + + DP+ Q +AA GAE +HL D A + Sbjct: 38 VYPTMELQNGRCVTLDKGRLDEPMIWHVDPVETAQGWAAAGAEWMHLTDFD-AIEGRDTN 96 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ ++ +PVQ+ GG RS E V ++ G R+V+G+ A + + K + + Sbjct: 97 SALVEQIIRSAELPVQLAGGFRSREQVERWIDKGAGRIVIGTLAARDPHLFKELAKLYPD 156 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +VLA+DV V GW+ S S E +E + L +L TDI D Sbjct: 157 Q-IVLAVDVWQ-----GYVMTDGWRTQSAFSPEAFIEAFADAPLAAILVTDIDSDMVDVE 210 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIA 240 + + L + A + +SG + DD++ L + GV+VGRAL + EA+A Sbjct: 211 AQLGLISGLAAH-SRTPVIASGVVRSSDDISRLAYIPNISGVLVGRALFRKTVDLSEALA 269 Query: 241 CWQNA 245 + A Sbjct: 270 VARTA 274 >UniRef50_Q2SCV5 Imidazoleglycerol-phosphate synthase n=1 Tax=Hahella chejuensis KCTC 2396 RepID=Q2SCV5_HAHCH Length = 255 Score = 203 bits (517), Expect = 5e-51, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 105/247 (42%), Gaps = 8/247 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK-- 59 IIP L L G +V+ Q + DP+ + Y AQ A+ L +D+ + + Sbjct: 6 IIPMLLLSQGRMVKGKQFSAFRDT---GDPVSAARIYNAQFADELVFLDVDANRQGSDFE 62 Query: 60 RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERF 119 + + LI + + +P+ VGGGV S E V L+++G +VV+ + A+++ ++ F Sbjct: 63 QLLNLIDKVSSECFMPLSVGGGVNSVEQVRRLVQSGADKVVITTAALENPGLINDASAIF 122 Query: 120 GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 G +V+ LDV+ E G ++ + + LE+ + G + + RDG + Sbjct: 123 GRQCIVVGLDVKR-EDGAYRLYSHCGRHKTERELEEFIRDMTQRGAGEFIVNAVDRDGMM 181 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEA 238 G ++ + + ++GG G + A + V+ G A Sbjct: 182 QGYDLEMI-KCAKAVTDRPVLAAGGAGTFAHLTAAFQEANADAVVCASIFHFGDNNPIRA 240 Query: 239 IACWQNA 245 + NA Sbjct: 241 RSHLLNA 247 >UniRef50_A5INE6 Imidazole glycerol phosphate synthase subunit hisF n=7 Tax=cellular organisms RepID=HIS6_THEP1 Length = 254 Score = 202 bits (515), Expect = 8e-51, Method: Composition-based stats. Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 5/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ DG VV+ ++ RD DP+ + Y+ G + L +D+T + + K Sbjct: 6 IIACLDVKDGRVVKGT--NFENLRD-SGDPVELGKFYSEIGIDELVFLDITASVEKRKTM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L++ + +++P VGGG+ E + L+ G +V + + AV+ ++ FG+ Sbjct: 63 LELVEKVAEQIDIPFTVGGGIHDFETASELILRGADKVSINTAAVEDPSLITKIARTFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A+V+A+D + G V ++N+G+ L V G +L T I RDGT AG Sbjct: 123 QAVVVAIDAKKV-DGEFVVFTYSGKKNTGILLRDWVVEVERRGAGEILLTSIDRDGTKAG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + + V + +SGG G ++ G + + V+E Sbjct: 182 YDTEMIRFVRP-LTTLPIIASGGAGKMEHFLEAFLAGADAALAASVFHFREIDVRELKEY 240 Query: 242 WQ 243 + Sbjct: 241 LK 242 >UniRef50_B8FFL4 Imidazole glycerol phosphate synthase subunit hisF n=19 Tax=cellular organisms RepID=HIS6_DESAA Length = 260 Score = 201 bits (513), Expect = 1e-50, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 107/249 (42%), Gaps = 10/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ DG + +G K DP+ + Y G + L D+T + + Sbjct: 6 VIVCLDVRDG---KTTKGIKFKGNVDIGDPVDMARVYYEAGCDELVFYDITASHEKRGIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I +++ + + +P VGGG+ S ED+ +L AG ++ V S AVK+ ++ E FG Sbjct: 63 IDVVRRVAETIFIPFSVGGGISSVEDMRDVLLAGAEKISVNSAAVKNPKIITQGAEAFGN 122 Query: 122 DALVLALDVRIDEQ-----GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +VL +DV+ E+ ++ ++G + G+ + +G + I D Sbjct: 123 QCVVLGMDVKKVEKSEKIPSGYEIVINGGRTYMGIDALWWAQEGERLGAGEICLNSIDAD 182 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTV 235 GT G + L + + + +SGG G + L+ ++ + G +T+ Sbjct: 183 GTKEGYELELTA-LISENVNIPVIASGGGGIPQHLGDVLKEGKADAALIASMVHYGTYTI 241 Query: 236 KEAIACWQN 244 E ++ Sbjct: 242 PEIKDHLKS 250 >UniRef50_D1U7I5 Histidine biosynthesis protein n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1U7I5_9DELT Length = 289 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 103/233 (44%), Gaps = 5/233 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +V+ + R G P + Y GA+ L D + Sbjct: 5 IIPRLDIKGPNLVKGIH--FEGLRVLGK-PEDFARHYYENGADELFFQDAVASLYDRNSL 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++K + + +P+ VGGG+RS +D+ A+L AG +V + + A+K ++++ FG+ Sbjct: 62 HDIVKRTSSEIFIPLCVGGGLRSVDDIRAVLRAGADKVAINTEAIKRPELIREASVAFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V++++ G + V +E +GV+ + + +G ++ T I ++GT G Sbjct: 122 STIVVSIEAIRRANGEWEALVEYGRETTGVNAVEWAKRACELGAGELMITSIDQEGTGKG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKF 233 ++ L + A V + GG G D A + G V + L Sbjct: 182 YDIELTRAI-ASAVSVPVIAGGGCGSPADAANVITQGRADAVSMASVLHYKTI 233 >UniRef50_Q3SPZ7 Histidine biosynthesis n=1 Tax=Nitrobacter winogradskyi Nb-255 RepID=Q3SPZ7_NITWN Length = 258 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 56/229 (24%), Positives = 102/229 (44%), Gaps = 3/229 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L DG +V+ + + +R G +P+ + Y G + L ++D+ + R Sbjct: 6 LIPKFLLRDGRLVK-YTCFFDNERIAG-NPVTTAKVYNDYGVDELIVLDIVPSAASRARV 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + + +P VGGGV++ EDV ALL AG +V + S AV+ + V+ FG Sbjct: 64 EDIIGRMSEEIFMPFTVGGGVKTAEDVNALLRAGADKVSINSEAVRRPEFVREAARTFGD 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D + + V + G +E+ + + + +L + I RDGT+ G Sbjct: 124 QCITVSIDYKRIGSHHASVYIDGGREHVALDPVEWALRCEDLHCGEILMSSIDRDGTMQG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 ++ + + R V SGG G + G V + L Sbjct: 184 YDLEMINTLTKRL-GVPMIVSGGCGSLQHAIDALEAGASAVAISSMFLF 231 >UniRef50_C5BV99 Imidazole glycerol phosphate synthase subunit hisF n=14 Tax=Bacteria RepID=HIS6_BEUC1 Length = 256 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 71/249 (28%), Positives = 114/249 (45%), Gaps = 9/249 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P LD+ G VV+ ++ RD G DP+ + Y A GA+ + +D++ + Sbjct: 7 VVPCLDVDGGRVVKGV--NFLDLRDAG-DPVELARRYDADGADEITFLDVSASTQGRATT 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ V VP+ VGGGVR+ DV ALL AG +V V + A+ +++ + +G Sbjct: 64 LEMVSATAEQVFVPLTVGGGVRAVADVEALLRAGADKVGVNTAAIARPELLTEIAQHYGN 123 Query: 122 DALVLALDVRIDEQG-----NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 LVL++D R G +V G + +G+ + G VL I D Sbjct: 124 QVLVLSVDARRCPDGVVTDSGFEVTTHGGRTGTGIDAVEWAAEATSRGAGEVLLNSIDAD 183 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 GT AG +V + E V A +SGG G ++D A G V+ G T+ Sbjct: 184 GTTAGFDVEMIEAVRA-VVDTPLVASGGAGTVEDFVAAARAGADAVLAASVFHYGTLTIS 242 Query: 237 EAIACWQNA 245 E A ++A Sbjct: 243 EVKAALRDA 251 >UniRef50_C4FS06 Putative uncharacterized protein n=1 Tax=Veillonella dispar ATCC 17748 RepID=C4FS06_9FIRM Length = 256 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 64/249 (25%), Positives = 109/249 (43%), Gaps = 9/249 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L + +G V G + DP+ + Y QGA+ L L+D+T + K Sbjct: 6 IIPCLGVANGRV---QNGVQFRDMVDAGDPVECAERYEIQGADELVLLDITATTEARKTF 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ V +P+ VGGG+ S ED+ L++AG +V + + A+ + ++ ++FG Sbjct: 63 TDIVLNASDKVFMPLTVGGGITSVEDMTQLMKAGADKVSINTAALSNPSLITEGAKKFGN 122 Query: 122 DALVLALDVRIDEQGN-KQVAVSGWQENSG---VSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+ LDV+ + G + G + + + + G +L T I R G Sbjct: 123 QGIVVCLDVKYNPFEKMWYAYGHGTSNDPGAQCKNALEWAKEAVDRGAGELLVTSIDRHG 182 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVK 236 T G ++ LY+ + A V + GG G+I L T V G + L T+K Sbjct: 183 TGLGFDIELYQAL-AEVVDVPVTAFGGAGNIQHFVDLFTKTNVTGALASALLHNKVLTIK 241 Query: 237 EAIACWQNA 245 + A Sbjct: 242 DIKKALHAA 250 >UniRef50_A5FQU7 Histidine biosynthesis protein n=5 Tax=Dehalococcoides RepID=A5FQU7_DEHSB Length = 268 Score = 200 bits (508), Expect = 5e-50, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 112/248 (45%), Gaps = 9/248 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ + DP Y+ QGA+ L +D+T + + Sbjct: 6 IIPCLDVKDGRVVKEIK---FTDMADARDPAEAAFVYSKQGADELAFLDITATIENSSIH 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +K +++ ++P+ GGG+R+ +D+ L GV+ V + + ++Q+ ++ RFG+ Sbjct: 63 TDWVKKIISKTSLPLIAGGGIRNLQDIENLFTLGVSNVALNTITPQNQEFIRKAVARFGS 122 Query: 122 DALVLALDVRIDEQGNK----QVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 + +++A+D + GN + + + + L + +G +L T DG Sbjct: 123 ERIIVAIDGIKNPPGNGHPRLETVMPNGDDTHNLELVDWAKQVEALGAGAILLTSKDTDG 182 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTVK 236 T G ++ + V R + +SGG G ++D+ AA+ + V+ G + Sbjct: 183 TKDGFDMEMIRSVT-RAVSIPVIASGGAGKLEDMYAAIIEGKAQAVLAASVFHSGIINIS 241 Query: 237 EAIACWQN 244 E + Sbjct: 242 ELKTYLHS 249 >UniRef50_Q1AX07 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=HIS4_RUBXD Length = 243 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 103/243 (42%), Positives = 141/243 (58%), Gaps = 10/243 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++ PA+DL G VRL QGD+G++R Y DP+ R +++ +GA LH+VDL GA++ Sbjct: 8 VVFPAIDLKGGRCVRLRQGDFGRERVYDADPVGRAREWERRGARALHVVDLDGAREGRPV 67 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 Q+ LI+ + VP+QVGGG+R+ EDV A AG ARVVVG+ AV +D E G Sbjct: 68 QLALIREIARAAGVPLQVGGGIRTLEDVRAARRAGAARVVVGTAAVADRDFRLRALEELG 127 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 AD LV+A+D R VA GWQ SGV +L G++ VL TDISRDGT Sbjct: 128 AD-LVVAVDAR-----EGVVATHGWQRQSGVGAAELAGELAAEGVRAVLFTDISRDGTGE 181 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAI 239 G+ + EV + +SGG+ D+ AL T GV G +VG AL EG+ T++E + Sbjct: 182 GAALERTAEV---AGIIPTIASGGVRGAGDIRALARTPGVVGAVVGTALYEGQATLEELL 238 Query: 240 ACW 242 A Sbjct: 239 AAA 241 >UniRef50_C2FZQ4 Possible isomerase n=2 Tax=Sphingobacterium spiritivorum RepID=C2FZQ4_9SPHI Length = 250 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 82/243 (33%), Positives = 137/243 (56%), Gaps = 12/243 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPA+D++D VVRL +G+Y Y ++ Y A G E++H++DL GAK Sbjct: 3 IIPAIDVLDKKVVRLREGNYDDVTTYDISLEEQIDRYHANGTELVHIIDLNGAK-GDFSN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF----- 116 + ++ + +Q GGGVRS E V L++AGV RV+VG+ A+ + + ++ Sbjct: 62 QEYLFNIIRKTEMKIQYGGGVRSIEKVKELIDAGVFRVIVGTQAITNPEFLEELSTLNEG 121 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 + AD +V+A+DV ++ + SGW E+S + L + ++ L +G LCTDIS+D Sbjct: 122 KIKYADHIVIAIDV-----LDEVIKYSGWLESSPIKLIEYIDKCLALGFYRFLCTDISKD 176 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-VRGVIVGRALLEGKFTV 235 G L G+ V LY+++ P + SGGI +DD+ L+ G + +VG+A+ E + ++ Sbjct: 177 GKLGGAGVELYKKLLDHSPIIKLIGSGGISSMDDIRKLQELGRMESCVVGKAIYENRISI 236 Query: 236 KEA 238 +E Sbjct: 237 EEI 239 >UniRef50_A8ESN1 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Arcobacter butzleri RM4018 RepID=A8ESN1_ARCB4 Length = 256 Score = 198 bits (504), Expect = 1e-49, Method: Composition-based stats. Identities = 47/235 (20%), Positives = 115/235 (48%), Gaps = 6/235 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L G L++ + K+ Y DP+ ++ + + + L +D+ + + + Sbjct: 7 VIPCLLLHKGG---LYKTEKFKKPTYIGDPINAIKIFNEKEVDELMFIDIDASVEDREPN 63 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ + + +P+ GGGV++ E + + GV +V + S A+ + +++K FG Sbjct: 64 YKMIEDIASECFMPLCYGGGVKNIEQMKKIYALGVEKVSISSQAIINPNLIKEAARLFGN 123 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++++ +D++ D GNK++ ++ ++N+ ++ ++ +G ++ DG + G Sbjct: 124 QSVIVTIDIKKDFWGNKKIFINNGKKNTKLNPIDFIKQVESLGAGEIVINSCDNDGIMKG 183 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG-TGVRGVIVGRAL-LEGKFT 234 ++ L +E+ +V + GG G+++ + + + V V G +G Sbjct: 184 YDIELLKEI-KENTKVPIIALGGAGNLNHIKDVFESSKVDAVACGSMFVYQGPLK 237 >UniRef50_C4L175 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Exiguobacterium sp. AT1b RepID=C4L175_EXISA Length = 237 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 78/239 (32%), Positives = 134/239 (56%), Gaps = 10/239 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+DLI G +VRL +GD+ + YG DP L+ + ++HL+DL GAK R Sbjct: 3 LLPAIDLIGGKIVRLTEGDFSTEEQYG-DPYELLKAW-QGKVPMIHLIDLEGAKAGEPRH 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ + + VQ GGG+RSE + A++E G RV++G+ A D + E++G Sbjct: 61 LDVVRYAKSLGFL-VQTGGGIRSEASLDAVMETGADRVLLGTKAFTDPDFLDKAIEKYG- 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +ALD + +VA++GWQE + + + + + G++ +L TDI DG L G Sbjct: 119 KRVAVALDAY-----DGKVAINGWQEATKLDDISVAQDLVKRGIETILYTDIGSDGKLNG 173 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 NV+ + + + V +SGG+ +DV L+ + +VG+ALL GK +++E I Sbjct: 174 PNVTRMKALR-QIVNVTLIASGGVTTEEDVKELKMAKIDEAVVGKALLSGKVSIEELIE 231 >UniRef50_A2C5V2 Imidazoleglycerol-phosphate synthase n=2 Tax=Prochlorococcus marinus RepID=A2C5V2_PROM3 Length = 500 Score = 196 bits (500), Expect = 5e-49, Method: Composition-based stats. Identities = 56/242 (23%), Positives = 108/242 (44%), Gaps = 5/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ +++ + + R G DPL + YA G + L +D + Sbjct: 19 IIARLDVKGNKIIKGVR--FEGLRVIG-DPLDMARKYAKAGIDELLYIDAVASLYGRNSL 75 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I ++K+ + V +P+ GGG+R+ ED LL G ++ + + A++ ++ G+ Sbjct: 76 IEVLKSTSSEVFIPITAGGGIRNLEDAKLLLSNGADKIAINTAALECPQLISELSNTLGS 135 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++ R + +E SG+ + + +E +G +L T + +DGT Sbjct: 136 QCVVVSIQARASSSSSWDAMKESGREKSGIDVIKWIENVQLLGAGEILLTSVDQDGTCIK 195 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTVKEAIA 240 + L ++V ++ SGG D + V AL + + V +G AL K V + + Sbjct: 196 PDEILIQKVLPIL-KLPLIVSGGFSDPNQVYQALTNSRISAVAIGAALHYQKTNVSDIKS 254 Query: 241 CW 242 Sbjct: 255 ML 256 >UniRef50_A4EBZ6 Putative uncharacterized protein n=2 Tax=Collinsella RepID=A4EBZ6_9ACTN Length = 247 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 88/250 (35%), Positives = 133/250 (53%), Gaps = 14/250 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAK- 59 ++ PA+DLI G VVRL +GD + + Y +DP+ + +A QGA +H+VDL+ A + Sbjct: 2 ILFPAIDLIGGKVVRLERGDRSRCKVYSDDPVAVARSFAEQGASWVHVVDLSSAFGEDED 61 Query: 60 ---RQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 IK + + V VGGGVRS + L G R+ +G+ V + Sbjct: 62 TCAANSAAIKAICGVDGLSVDVGGGVRSLARIDELAGYGARRIALGTVLVTEPGFAEVAA 121 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 + FG + LV + R + QV V+GW++ +GV+L+ V +G KH++ TDI+RD Sbjct: 122 QGFG-ELLVADIAAR-----DGQVKVNGWRDGAGVALDDAVAQLSELGFKHLVYTDIARD 175 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGRALLEGKF 233 G G +V+ Y V A +SGGI +DD+ AL G + G I GRAL EG F Sbjct: 176 GMQTGIDVAAYRHV-AEVAGFPVVASGGISALDDIRALAAVGEGAIEGAITGRALYEGNF 234 Query: 234 TVKEAIACWQ 243 T+ +A+A + Sbjct: 235 TLAQALAAAR 244 >UniRef50_C6UMW5 Putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW5_HODCD Length = 241 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 72/241 (29%), Positives = 113/241 (46%), Gaps = 10/241 (4%) Query: 5 ALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPL 64 ++D+ +G VRL +G R Y + PL ++ + Q +++H+VDL GA + + Sbjct: 6 SIDVKNGECVRLCRGQMADCRVYASSPLEAVRKFNLQCCDLVHIVDLDGAVCGSPQNWRS 65 Query: 65 IKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADAL 124 I + VQVGGGVR+ D LE G ++VV+G++A+ + V + + Sbjct: 66 ILEAARQLKGCVQVGGGVRTLADAKLYLEGGASKVVLGTSAIADMEFVCHVSWLYPG-RV 124 Query: 125 VLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNV 184 + +D + VA GW S V +QLV + ++ TDI+RDGTL G N Sbjct: 125 CVGVDT-----FGELVATDGWTAVSCVRCDQLVPKLEAARVSCLIWTDINRDGTLQGVNF 179 Query: 185 SLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGRALLEGKFTVKEAIAC 241 + V A V SGG+ D+ L + GVI G+AL E T + A + Sbjct: 180 DALDRVLA-ASAVPVIVSGGVATALDLIKLHNLYADKLAGVICGKALYERTLTARFARSI 238 Query: 242 W 242 Sbjct: 239 L 239 >UniRef50_B8FJR2 Histidine biosynthesis protein n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FJR2_DESAA Length = 262 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 56/199 (28%), Positives = 93/199 (46%), Gaps = 8/199 (4%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDV 88 DP+ + + Y AQ A+ L +DL + + +I + +P+ VGGGVRS ED Sbjct: 38 GDPVSQAKIYQAQAADELVFLDLDASIEHRDALTDIIAKAAEEIFMPITVGGGVRSVEDC 97 Query: 89 AALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQEN 148 LL G +V + + A++ +++ + FGA +V+++D + G +V G + + Sbjct: 98 RRLLNHGADKVSINTGAMEIPELINQGSDMFGAQCIVVSIDYKKHPNGAYEVFTRGGKSS 157 Query: 149 SGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDI 208 +G+ G +L T I RDGT G N+ L +V A + +SGG G Sbjct: 158 TGLDPVAWAVEAQHRGAGEILLTSIDRDGTRKGLNLELTAKV-AGAVDIPVITSGGCGLA 216 Query: 209 DDVAALRGTGVRGVIVGRA 227 V G +VG+A Sbjct: 217 SHF-------VDGFLVGKA 228 >UniRef50_C6UMW6 Putative imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Candidatus Hodgkinia cicadicola Dsem RepID=C6UMW6_HODCD Length = 264 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 63/239 (26%), Positives = 106/239 (44%), Gaps = 6/239 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP +D+ +G VV+ G + Y+ GA+ L +D++ + Sbjct: 9 IIPCMDVKEGHVVK---GSKFCGLVRVGEATLVANSYSVSGADELCFLDVSASSANRSIL 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I + +P+ VGGGVR +DV LL AG +V + S V S + + ++FG+ Sbjct: 66 YATISQVAESCLIPLTVGGGVRRVKDVGDLLRAGADKVSINSAGVLSPEFIARCVDKFGS 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D + G +V G +GV + G +L T + RDG AG Sbjct: 126 QCVVVSIDCK-ASDGAWEVCTHGGARPTGVDALEYACQAAQFGAGEILLTSVDRDGVKAG 184 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRALLEGKFTVKEAI 239 +++L + V + V +SGG G++ A AL G V+ L + TV + Sbjct: 185 YDLALLKAV-SSLVSVPVIASGGGGELSHFALALIEGGASAVLTASLLHRNELTVSQLK 242 Score = 39.8 bits (92), Expect = 0.079, Method: Composition-based stats. Identities = 27/115 (23%), Positives = 45/115 (39%), Gaps = 1/115 (0%) Query: 25 RDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRS 84 R G D L A GA + L + A + L+K + + V+VPV GG Sbjct: 150 RPTGVDALEYACQAAQFGAGEILLTSVDRDGVKAGYDLALLKAVSSLVSVPVIASGGGGE 209 Query: 85 EED-VAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNK 138 AL+E G + V+ S +++ V G+ +V+ D ++ Sbjct: 210 LSHFALALIEGGASAVLTASLLHRNELTVSQLKFFLGSCGIVVRDDYVRFGSRDE 264 >UniRef50_C9RKR3 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RKR3_FIBSS Length = 263 Score = 195 bits (495), Expect = 1e-48, Method: Composition-based stats. Identities = 58/240 (24%), Positives = 107/240 (44%), Gaps = 10/240 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ + V +G K DP+ Y+ +G + L D+T + + Sbjct: 6 LIVCLDVRNRKV---TKGVKFKGNIDIGDPVEMGARYSDEGVDELVFYDITASAENRPCD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ + V +P VGGG+R+ +D+ L AG +V V S AV +++ + FG Sbjct: 63 MEMIRQIAKRVFIPFAVGGGIRNLDDMHEALLAGAEKVSVNSLAVLHPEIIAEGAKAFGR 122 Query: 122 DALVLALDVRIDEQGN-----KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +VL +D + + +V + G ++ G+ Q + +G+ + I D Sbjct: 123 QCIVLGMDAKFVGVSDKIPSGYEVFIRGGRQAMGIDALQWAKRAEELGVGEICLNSIDTD 182 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTV 235 G G +++ + + A+ QV +SGG G + L R T +V + G +TV Sbjct: 183 GVKNGYELTITDMI-AKAVQVPVIASGGAGTPAHIVDLFRKTSADAALVASMVHFGDYTV 241 >UniRef50_Q2P3J8 Imidazole glycerol phosphate synthase subunit hisF n=360 Tax=Bacteria RepID=HIS6_XANOM Length = 258 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 52/247 (21%), Positives = 100/247 (40%), Gaps = 9/247 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +G VV+ + + D G D + Y AQGA+ L D+ + + Sbjct: 6 IIPCLDVRNGRVVKGVK--FHDHIDMG-DIVELALRYRAQGADELVFYDIGASPEGRSVD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ + +++P V GG+ E A+L AG ++ + S A+ ++ + FG Sbjct: 63 YTWVERVARLIDIPFCVAGGIGDVETARAVLHAGADKISINSPALGRPQLISELADAFGV 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGW----QENSGVSLEQLVETYLPVGLKHVLCTDISRDG 177 +V+ +D ++ G +V + + V +G ++ + DG Sbjct: 123 QCVVVGIDSIREDDGQWRVRRYTGDPSKTQALPMRTLDWVAEAQRLGAGEIVLNCMDNDG 182 Query: 178 TLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVK 236 G +++ +V A V +SGG G++ A + V G + G + Sbjct: 183 VRRGYDIAQLRQVRA-LCHVPLIASGGAGEMQHFADVFDQADVDGALAASVFHSGAIPIP 241 Query: 237 EAIACWQ 243 E + Sbjct: 242 ELKQFLR 248 >UniRef50_A8A8V9 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase n=1 Tax=Ignicoccus hospitalis KIN4/I RepID=A8A8V9_IGNH4 Length = 235 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 69/241 (28%), Positives = 123/241 (51%), Gaps = 11/241 (4%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + P++D+ +G V+ +G G D G DP+ + +A +GA+ LH+VDL GA+ Sbjct: 3 VFPSIDVSEGRAVKRVRGVKGTGLDLG-DPVKWAEFWALEGAKGLHVVDLDGAEAGKPIN 61 Query: 62 IPLIKTL---VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + +I + + VQV GG+R E + + V+GS A K + ++ E Sbjct: 62 VEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPK--ADAFVIGSRAHKDPEFLEVASEA 119 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 GAD +++A+D++ +V+V GW+E V L++ +E + + L T + +GT Sbjct: 120 VGADKVIVAIDLK-----GGKVSVEGWKEEIPVGLKEALEKFKGRSFRGFLYTYVDTEGT 174 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 + G +VS + + YP + +GG+G + V L G V++G AL GK +K+ Sbjct: 175 MEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDL 234 Query: 239 I 239 + Sbjct: 235 V 235 >UniRef50_C8PKX5 Imidazole glycerol phosphate synthase subunit hisF n=3 Tax=Bacteria RepID=C8PKX5_9PROT Length = 306 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 111/296 (37%), Gaps = 59/296 (19%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ DG VV+ ++ D G DP+ + Y +GA+ L +D+T + Sbjct: 8 IIPCLDVKDGRVVKGV--NFVGLVDAG-DPVEIAKRYNEEGADELCFLDITASHLGRDTI 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +++ + + +P+ VGGG+R+ +D++ LL G ++ + S A+K+ +++ +FG+ Sbjct: 65 VDVVERVARELFIPLTVGGGIRTIDDISRLLNVGCDKISLNSAAIKNPNLIDEAANKFGS 124 Query: 122 DALVLALDVRID--EQGNKQVA---------VSGWQENSGVSL----------------- 153 +V+A+D + + E + + G N +L Sbjct: 125 QCVVIAIDAKRNSIEISRGDLYGEARNSNGDLHGGMRNPDTNLGSEARNFGEILRGAQDE 184 Query: 154 --------------------------EQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLY 187 + G +L T + DG G ++L Sbjct: 185 ILTGNGELCGYSVFINGGRLDTGRDALAWAKEAQERGAGEILLTSMDCDGVKNGFELNLT 244 Query: 188 EEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQ 243 A + +SGG G ++ G + + +K A Q Sbjct: 245 RIFSAL--DIPVIASGGAGKMEHFKDAFLAGADACLAASIFHFREIEIKALKAYLQ 298 Score = 50.2 bits (119), Expect = 6e-05, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 39/107 (36%), Gaps = 4/107 (3%) Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 A ++ LDV+ V ++G ++ + Y G + DI+ Sbjct: 5 AKRIIPCLDVKDGRVVKGVNFV--GLVDAG-DPVEIAKRYNEEGADELCFLDITASHLGR 61 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 + V + E V + GGI IDD++ L G + + A Sbjct: 62 DTIVDVVERVAREL-FIPLTVGGGIRTIDDISRLLNVGCDKISLNSA 107 Score = 42.8 bits (100), Expect = 0.010, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 40/116 (34%), Gaps = 9/116 (7%) Query: 11 GTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHL--VDLTGAKDPAKRQIPLIKTL 68 G V ++ G G D L ++ +GA + L +D G K+ + + + Sbjct: 194 GYSVFINGGRLDT----GRDALAWAKEAQERGAGEILLTSMDCDGVKNGFELN---LTRI 246 Query: 69 VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADAL 124 + +++PV GG E AG + S + +K + Sbjct: 247 FSALDIPVIASGGAGKMEHFKDAFLAGADACLAASIFHFREIEIKALKAYLQEQGI 302 >UniRef50_C5BRY3 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Bacteria RepID=C5BRY3_TERTT Length = 259 Score = 193 bits (492), Expect = 4e-48, Method: Composition-based stats. Identities = 61/240 (25%), Positives = 109/240 (45%), Gaps = 5/240 (2%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQI 62 I LD+ +++ R G DP + Y QGA+ L +DL + + Sbjct: 12 IARLDVKGDQLIKAIH--LEGLRVVG-DPQIYAKRYYEQGADELLYIDLVASLYGRNKLK 68 Query: 63 PLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGAD 122 ++ + +P+ VGGG+RS EDV LL AG +V + + AV + +++ RFG+ Sbjct: 69 DIVSRTAQDIFIPLTVGGGIRSVEDVTELLAAGADKVAINTAAVANPALIEQVALRFGSQ 128 Query: 123 ALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGS 182 +VL+++ + + +V +E+SG + + + G +L T I ++GT G Sbjct: 129 CMVLSIEAKRLGEDRWEVYTDCARESSGRDVIAWAKEAVERGAGEILLTSIDQEGTRKGF 188 Query: 183 NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIV-GRALLEGKFTVKEAIAC 241 + +L V A +V +SGG G + + A+ G I AL + T+ + Sbjct: 189 DTALTAAV-AETVRVPVIASGGYGQPEHINAITHQGSANAIAFADALHFERETIASLKSY 247 >UniRef50_P72139 Putative imidazole glycerol phosphate synthase subunit hisF2 n=9 Tax=cellular organisms RepID=HIS62_PSEAE Length = 251 Score = 193 bits (490), Expect = 7e-48, Method: Composition-based stats. Identities = 48/228 (21%), Positives = 98/228 (42%), Gaps = 4/228 (1%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L D +V+ + K+ Y DP+ ++ + + + L L+D+ ++ + Sbjct: 6 VIPCLLLKDRGLVKTVK---FKEPKYVGDPINAIRIFNEKEVDELILLDIDASRLNQEPN 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI + +P+ GGG+++ E + GV +V + + A+ +++ ++FG+ Sbjct: 63 YELIAEVAGECFMPICYGGGIKTLEHAEKIFSLGVEKVSINTAALMDLSLIRRIADKFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V ++D R G V + S + + G+ + I RDG G Sbjct: 123 QSVVGSIDCRKGFWGGHSVFSENGTRDMKRSPLEWAQALEEAGVGEIFLNSIDRDGVQKG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 + +L E + + V + GG G I D+ L + +L Sbjct: 183 FDNALVENIASN-VHVPVIACGGAGSIADLIDLFERTCVSAVAAGSLF 229 >UniRef50_B6BGE0 Imidazole glycerol phosphate synthase, cyclase subunit HisF n=1 Tax=Campylobacterales bacterium GD 1 RepID=B6BGE0_9PROT Length = 254 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 47/244 (19%), Positives = 103/244 (42%), Gaps = 5/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I +D+ + +G + + +P Y G + + L+D + Sbjct: 6 VIARIDIKNE---HTIKGIHLEGLRKVGNPNEMALRYYEDGIDEIVLMDAVASLYDRNSL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I + +P+ VGGG+R+ +D+ L +G +V + + A++ + ++FG+ Sbjct: 63 KDVIVKACEDIFIPITVGGGLRNLQDIQEALNSGADKVAINTQAIREPSFITTASKQFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++ ++ + + G + + +E +GV + + +G ++ T I ++GT G Sbjct: 123 QCIISSIVAKKIDDGKWEAYIENGREPTGVDVLAWAKEVQELGAGEIMLTSIDKEGTKKG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ L + V A + SSGG G D+ L + + V + L +V E Sbjct: 183 FDLELNKAV-AELVNIPVISSGGAGSTKDIVHLCESSDIDAVAIASILHYKLESVSEIKK 241 Query: 241 CWQN 244 N Sbjct: 242 TLIN 245 >UniRef50_A6T0B3 Imidazoleglycerol phosphate synthase n=4 Tax=Proteobacteria RepID=A6T0B3_JANMA Length = 253 Score = 190 bits (483), Expect = 4e-47, Method: Composition-based stats. Identities = 52/227 (22%), Positives = 105/227 (46%), Gaps = 5/227 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P L + G +V+ Q K+ Y DP+ ++ + + + L L+D+T + Sbjct: 6 VMPCLLMDQGALVKTVQ---FKKPTYIGDPVNAVRIFNQKEVDELLLIDITATTEKRGID 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ LV +P+ GGGV + D+ L G+ ++ + + A+ + ++V+ FG Sbjct: 63 FETLEKLVTECFMPICYGGGVDNLVDMRRLYHLGIEKISLSAAAITNPELVREAAAEFGN 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 A+V+ LDV+ + G V + ++ S ++ G +L I +DGT +G Sbjct: 123 QAIVVTLDVKKNLFGKHTVRTHQGKTDTKRSPVEVAREMEQAGAGEILLYSIDKDGTWSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVA-ALRGTGVRGVIVGRA 227 ++ L + V R + + GG G++ + A+ G V +G Sbjct: 183 FDLDLIQNVT-RAVGIPVIACGGAGELAHLRSAVNEAGASAVAIGSM 228 >UniRef50_B0R4B2 Imidazole glycerol phosphate synthase subunit hisF n=24 Tax=cellular organisms RepID=HIS6_HALS3 Length = 273 Score = 189 bits (482), Expect = 4e-47, Method: Composition-based stats. Identities = 58/261 (22%), Positives = 106/261 (40%), Gaps = 20/261 (7%) Query: 2 IIPALDLI---DGT-VVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP 57 +IP +D+ DG V + G ++ Y DP+ + Y GA+ +D+T + + Sbjct: 7 VIPCIDVDLDDDGEPAV--YTGVNFEELAYTGDPVEMAKRYNEAGADEFVFLDITASAEG 64 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFE 117 + + + + V +P+ VGGG+R +D+ L AG +V + S A+ +V + Sbjct: 65 RETMLDTVSAVADEVFIPLTVGGGIRDTDDIRETLRAGADKVSINSGAIADPSLVDRGAK 124 Query: 118 RFGADALVLALDVRIDEQGNK-------------QVAVSGWQENSGVSLEQLVETYLPVG 164 FG+ +V+++D R + V G +E +G+ + V+ G Sbjct: 125 AFGSQCIVISVDARRRFDEQGQHYTQVDGESCWFECTVHGGREGTGMDAIEWVQEAQRRG 184 Query: 165 LKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIV 224 + I DGT G +V L VC +S G G D+A G + Sbjct: 185 AGELFVNSIDADGTQDGYDVPLTAAVC-DAVSTPVIASSGCGAPGDMADAYDAGADAALA 243 Query: 225 GRALLEGKFTVKEAIACWQNA 245 ++++ E +A Sbjct: 244 ASIFHFDEYSIAETKETLADA 264 >UniRef50_Q2LTH2 Imidazole glycerol phosphate synthase, cyclase subunit n=3 Tax=Bacteria RepID=Q2LTH2_SYNAS Length = 254 Score = 189 bits (482), Expect = 5e-47, Method: Composition-based stats. Identities = 61/246 (24%), Positives = 121/246 (49%), Gaps = 7/246 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I+P LD+ +G VV+ + + +D G DP+ Y A+GA+ L ++D+ + K + Sbjct: 6 IMPCLDMKEGRVVKGIH--FVELKDAG-DPVENAAFYQAEGADELAMLDIAATLENRKTR 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + + + A + +P+ VGGG+ + ED+ +L+AG A++ + S AVK+ +V ++FG+ Sbjct: 63 LEWVNKVSAVLTIPLTVGGGISTLEDIELVLQAGAAKISMNSAAVKNPSLVSEAAKKFGS 122 Query: 122 DALVLALDVRIDEQ--GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTL 179 + + +A+D R + Q ++ VSG T +G +L T + DGT Sbjct: 123 EKITVAIDARRNSQMPSGFELVVSGGTLPVARDAVAWARTCQELGAGVILPTSMDGDGTR 182 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-AALRGTGVRGVIVGRALLEGKFTVKEA 238 AG ++ + + A + +SGG G ++D A++ G ++ +++ Sbjct: 183 AGYDIEYTKAI-ADAVDLPVVASGGAGKLEDFYEAVQKGGASILLAASVFHYRTLSIRAV 241 Query: 239 IACWQN 244 + Sbjct: 242 KQYLAD 247 Score = 40.9 bits (95), Expect = 0.034, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 38/98 (38%) Query: 26 DYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSE 85 D + + GA V+ + G A I K + V++PV GG Sbjct: 151 PVARDAVAWARTCQELGAGVILPTSMDGDGTRAGYDIEYTKAIADAVDLPVVASGGAGKL 210 Query: 86 EDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADA 123 ED ++ G A +++ ++ + + +++ AD Sbjct: 211 EDFYEAVQKGGASILLAASVFHYRTLSIRAVKQYLADR 248 >UniRef50_B3E201 Histidine biosynthesis protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E201_GEOLS Length = 282 Score = 189 bits (480), Expect = 9e-47, Method: Composition-based stats. Identities = 53/230 (23%), Positives = 99/230 (43%), Gaps = 5/230 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP LD+ +V+ R G DP+ Y GA+ L D+ + Sbjct: 6 IIPRLDIKGPNLVKGIH--LEGLRVLG-DPIAFAHYYYENGADELIYSDIVASLYQRNSI 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L+ V +P+ + GG+R+ D+ L AG +V + + A+++ D + FG+ Sbjct: 63 LDLVTETSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVRVFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+A++V ++ + +++SG+ V+ +G +L T I+ +GT G Sbjct: 123 STIVVAVEVVRNDDNSLIAYTENGRQSSGIEAVSWVQRVEELGAGEILLTSINAEGTGDG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLE 230 ++ L V + + + GG G + V + T VR V Sbjct: 183 YDMDLINRVVS-AVSIPVIAHGGAGKPEHVREVFATSDVRAAAVASMFHY 231 Score = 45.5 bits (107), Expect = 0.002, Method: Composition-based stats. Identities = 19/125 (15%), Positives = 45/125 (36%), Gaps = 4/125 (3%) Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ LD++ + + G + Y G ++ +DI Sbjct: 3 PVRIIPRLDIKGPNLVKG-IHLEGLRVLGD--PIAFAHYYYENGADELIYSDIVASLYQR 59 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 S + L E +R + +GG+ ++D+ G V + A +E + +A+ Sbjct: 60 NSILDLVTE-TSRSVFIPITLAGGLRTLNDIQKALRAGADKVCINTAAIENPDFIAQAVR 118 Query: 241 CWQNA 245 + ++ Sbjct: 119 VFGSS 123 >UniRef50_B4SDB6 Histidine biosynthesis protein n=9 Tax=Bacteria RepID=B4SDB6_PELPB Length = 256 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 57/243 (23%), Positives = 108/243 (44%), Gaps = 5/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +I LD+ L +G + + P Y QG + L +D + Sbjct: 6 LIARLDIKGPN---LIKGIHLEGLRVIGSPNEYALRYYQQGVDELIYMDCVASLYDRNHL 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I++ + VP+ VGGG+RS ED +L +G +V V + AV + ++ RFG+ Sbjct: 63 GDIIRSAAKDIFVPMTVGGGIRSVEDATQILRSGADKVAVNTAAVANPKLINEISRRFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +VL+++ + + +V +E +G+ + V+ + +G VL T + R+GT G Sbjct: 123 QCMVLSIEAKEVGKDRWEVYTDNGRERTGLDVIAWVKKGVAMGAGEVLLTSVDREGTRKG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIA 240 + +L + V A + +SGG+G +D+ + G V + L + + E Sbjct: 183 FDTALVKAVTAEVS-IPVIASGGMGKPEDLVGVVSVGGADAVAMADILHYNRAGIGEIRN 241 Query: 241 CWQ 243 + Sbjct: 242 VAK 244 >UniRef50_Q7V958 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Prochlorococcus marinus str. MIT 9313 RepID=HIS62_PROMM Length = 261 Score = 188 bits (477), Expect = 2e-46, Method: Composition-based stats. Identities = 58/237 (24%), Positives = 100/237 (42%), Gaps = 2/237 (0%) Query: 9 IDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTL 68 V + + +R G DP+ + + Y AQ A+ L LVDL G D + + + Sbjct: 19 RGPKPVLVITRQFDSKRAIG-DPVSQAKIYEAQLADELVLVDLEGTSDSWPILLDTLSNM 77 Query: 69 VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLAL 128 + P+ VGGG+ S E V LL+ G +VV+ S AV + ++ +G+ +V+++ Sbjct: 78 SESLATPLSVGGGITSFEQVQQLLDRGADKVVLNSGAVNNPQLIDLVANSYGSQCVVISI 137 Query: 129 DVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYE 188 D+R + ++ V + G + SL G +L T I DGT G ++ Sbjct: 138 DIRKESDLSRHVYIDGGSTATDWSLFSWANDCASRGAGELLITSIDNDGTGTGLDLDSIR 197 Query: 189 EVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIACWQNA 245 ++ + +SGG G A G V G + + + +NA Sbjct: 198 QLRYE-VNLPLIASGGCGLAQHFVAGYEVGASAVAAGTFFSQRDQNPMQCRSHIRNA 253 >UniRef50_Q6KZD5 Histidine biosynthesis protein HisF n=1 Tax=Picrophilus torridus RepID=Q6KZD5_PICTO Length = 249 Score = 187 bits (475), Expect = 3e-46, Method: Composition-based stats. Identities = 64/243 (26%), Positives = 111/243 (45%), Gaps = 6/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II ALD+ +G VV+ + + +D G DP+ Y QGA+ + +D++ + Sbjct: 6 IIAALDVRNGRVVKGVR--FMDIKDAG-DPVENAVIYQDQGADEIVFLDISATDEKRDIM 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I L+K++ +N+P VGGG+RS + LL G +V + + A+++ ++K G+ Sbjct: 63 IDLVKSVSRELNIPFTVGGGIRSVKTALNLLREGCDKVFLNTYAIENPWIIKEISRETGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 LV+A+D V + + NSG+ L + + +G +L T I DGT+ G Sbjct: 123 ANLVIAVDA--MYNNGYYVYKNAGRINSGLKLNEWLPMAEYLGAGEILLTSIDSDGTMKG 180 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + L E A + +SGG G + G G + L TV + Sbjct: 181 FDNRLISE-AASMIDIPVIASGGAGKPEHFLDAFMAGASGALAASILHFKINTVNDIKRY 239 Query: 242 WQN 244 ++ Sbjct: 240 LRS 242 >UniRef50_A1W0U8 Putative imidazole glycerol phosphate synthase subunit hisF2 n=17 Tax=delta/epsilon subdivisions RepID=HIS62_CAMJJ Length = 248 Score = 185 bits (470), Expect = 1e-45, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 101/241 (41%), Gaps = 8/241 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP + L +G +V+ ++ R G ++ Y A+ + L ++D+ +K Sbjct: 6 IIPCVLLKNGQLVKSI--EFKDFRTIG-HLTSTMRIYNARNVDELIILDIDASKSGE-ID 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ L +P+ +GGG+++ ED+ +L G ++ + S A++ D + RFG+ Sbjct: 62 FESIEDLAKECFMPLTIGGGIKTLEDIQKILNLGADKISINSKALEDMDFISKAANRFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V ++DV+ G V G S +L Y G +L T + +G G Sbjct: 122 QCIVCSIDVKRKG-GQFCVYDRG--NLLEKSPLELALEYEKKGAGELLLTSVDFEGRAKG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 ++ L + + ++ +GG+ + D G + K+T K+ Sbjct: 179 YDLELLKIFQNKL-KIPLIINGGLSNPSDGVEALNLGADALAGAYIFHFSKYTPKDVKEE 237 Query: 242 W 242 Sbjct: 238 L 238 >UniRef50_B9K9S2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Thermotoga neapolitana DSM 4359 RepID=HIS4_THENN Length = 248 Score = 185 bits (470), Expect = 1e-45, Method: Composition-based stats. Identities = 72/242 (29%), Positives = 117/242 (48%), Gaps = 15/242 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IPA+DL VVR+ +G Y DP+ ++ +G ++H+VDL+ A + + Sbjct: 2 LVIPAIDLYRKKVVRMVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEESDE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +P+++ L + + +Q+GGG+R E LL G R +V S ++ +K E Sbjct: 62 NLPVLEKLSSYAD-HIQIGGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKLKEI-- 118 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 V +LD R +VA GW + + LV GL+ ++ T+I +DGTL Sbjct: 119 GVNPVFSLDTR-----EGKVAFKGWLDEKDIDPVFLVNRLKEFGLEEIVHTEIEKDGTLK 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG------VRGVIVGRALLEGKFT 234 + SL E + A V ++GGI + ++GVIVGRA LEG T Sbjct: 174 EHDFSLTERI-ALETGVKVIAAGGISSERSLEEALEVHRRTNGLLKGVIVGRAFLEGTLT 232 Query: 235 VK 236 V+ Sbjct: 233 VE 234 Score = 43.6 bits (102), Expect = 0.007, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 50/121 (41%), Gaps = 8/121 (6%) Query: 124 LVLALDVRIDEQGNKQVAVSGWQENS---GVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ A+D+ + V G +EN+ +LVE + G + D+SR + Sbjct: 3 VIPAIDLYRKKVVR---MVKGKKENTIFYEKDPIELVEKLVEEGFSLIHVVDLSRAIEES 59 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 N+ + E++ + + GGI ++ L G G R IV +LE +K+ Sbjct: 60 DENLPVLEKLSSYADHIQI--GGGIRILEYAKKLLGMGFRRQIVSSKVLEDPSFLKKLKE 117 Query: 241 C 241 Sbjct: 118 I 118 >UniRef50_A1WSE3 Histidine biosynthesis n=1 Tax=Verminephrobacter eiseniae EF01-2 RepID=A1WSE3_VEREI Length = 229 Score = 184 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 56/208 (26%), Positives = 100/208 (48%), Gaps = 1/208 (0%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y +QGA+ L +D+ + +I+ + VP+ VGGG+RS DV +L +G Sbjct: 17 YYSQGADELVFMDIVASLYQRNNLAGIIERAADQIYVPITVGGGIRSLHDVRTMLCSGAD 76 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 +V + + AV ++ ERFG+ +VL+++ + G + V +E++G+ + V Sbjct: 77 KVAINTAAVARPGLIAEVSERFGSQCMVLSVEAKRKSGGGWEAFVDNGREHTGLDVVAWV 136 Query: 158 ETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT 217 + +G ++ T + ++GT G +V L V A V +SGG G D+ Sbjct: 137 RQAVALGAGEIMLTSVDQEGTRKGFDVDLVRTV-AGCVTVPIIASGGYGRPSDLQQAAEA 195 Query: 218 GVRGVIVGRALLEGKFTVKEAIACWQNA 245 G G+ + AL + T+ E A + A Sbjct: 196 GASGLAIADALHWQRATIAELKAHARAA 223 >UniRef50_Q2YZ70 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=60 Tax=Staphylococcus RepID=HIS4_STAAB Length = 234 Score = 183 bits (465), Expect = 4e-45, Method: Composition-based stats. Identities = 61/233 (26%), Positives = 112/233 (48%), Gaps = 8/233 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAA-QGAEVLHLVDLTGAKDPAKR 60 + PA+DLI T VRL +G Y + + Y+ + +H+VDL GAK R Sbjct: 4 LWPAIDLIGSTSVRLTEGKYDSEEKMSRSAEESIAYYSQFECVNRIHIVDLIGAKAQHAR 63 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + IK+L ++VGGG+R++ + AG+ +VG+ ++ D +K F Sbjct: 64 EFDYIKSLRRLTTKDIEVGGGIRTKSQIMDYFAAGINYCIVGTKGIQDTDWLKEMAHTFP 123 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++D + + V+GW+E++ ++L V+ + L ++ T I++DG ++ Sbjct: 124 G-RIYFSVDAY-----GEDIKVNGWEEDTELNLFSFVKQLSDIPLGGIIYTHIAKDGKMS 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 G N L ++ + + +SGGI D+ L V I+G+A + F Sbjct: 178 GPNFELTGQLV-KATTIPVIASGGIRHQQDIQRLASLNVHAAIIGKAAHQASF 229 >UniRef50_A2C1S3 Imidazole glycerol-phosphate synthase n=1 Tax=Prochlorococcus marinus str. NATL1A RepID=A2C1S3_PROM1 Length = 248 Score = 183 bits (465), Expect = 4e-45, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 107/244 (43%), Gaps = 6/244 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 II LD+ + V++ R G DP +Y QG E + +D + Sbjct: 3 IIGRLDVKNNHVIKGIH--LEGLRKVG-DPQELAVEYYKQGIEEIVFMDAVASLYNRNNL 59 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ V VP+ +GGG+RS +DV+ L AG +VV+ + V D+ K +++G+ Sbjct: 60 FHIIQKACEKVFVPIALGGGLRSLDDVSKALNAGADKVVINTALVNRIDLAKEIAQKYGS 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 LV +++ + + +V V +E + ++ G+ +L T I ++GT G Sbjct: 120 QCLVGSIEAKRENDS-WRVYVDNGREPTKHNVVDWAIKLKEAGVGEILLTSIDQEGTSKG 178 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVI-VGRALLEGKFTVKEAIA 240 ++ L +++ + +SGG G+ +A L I + +L K TV Sbjct: 179 FDIELIKQINESI-RCPIIASGGYGNKKHLADLLKIVEPSAIAIAGSLHYKKDTVSSIKQ 237 Query: 241 CWQN 244 + Sbjct: 238 EINS 241 >UniRef50_D1B9F8 Histidine biosynthesis protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B9F8_THEAS Length = 253 Score = 183 bits (465), Expect = 5e-45, Method: Composition-based stats. Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 5/243 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L RL +G + DP+ + AQGAE + LVD+ ++ Sbjct: 6 IIPQFLLKGS---RLVKGTSFRDHVDVGDPVSQAMIQDAQGAEEIVLVDVDATREGRLVD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI +V +P+ VGGGV + +D + L AG +V+V + AV + M++ ERFGA Sbjct: 63 TSLISRMVERCRLPIAVGGGVGNVDDASRLFVAGADKVIVNTAAVLNPSMIRPLAERFGA 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V++LD++ + + V +E + L+E G + T + R+GTL+G Sbjct: 123 QSVVVSLDLKRNSKRGWVPVVRSGEEEVDLDFVYLLEALEANGAGEFIVTSVDREGTLSG 182 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVKEAIA 240 ++ + +V +V +SGG G+ + L + GV +G+ L + V A Sbjct: 183 FDLDML-KVVREVVKVPLIASGGAGNYLHLVELFLSIDLEGVGIGKMLALRDYDVVRIKA 241 Query: 241 CWQ 243 + Sbjct: 242 FLK 244 >UniRef50_Q8TYD6 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Methanopyrus kandleri RepID=HIS4_METKA Length = 242 Score = 183 bits (464), Expect = 6e-45, Method: Composition-based stats. Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 10/237 (4%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 ++IP++D+++G V+L +GD ++ +DP+ ++ +H+VD+ A+ Sbjct: 4 VVIPSVDVVEGKCVQLVEGDPERRTFESDDPVETAHQWSEF-FPWIHVVDVDAAR-GEGD 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +I + V+ VQVGGG+RS E L+E G R++VG+ A +D + Sbjct: 62 NSDIIGRICEEVDAKVQVGGGIRSAERAEELIELGADRLIVGTVAFTDKDDFSKIVDVCH 121 Query: 121 ADAL--VLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 + +ALDV N +V VSGW+E++GV+LE +E + V L T + +G Sbjct: 122 DHGIEVFVALDV----NENHEVLVSGWKEDAGVTLEDAIERFNEV-ADGYLTTAVHVEGK 176 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 G + + E+ + +GGI I DV + G GV++G AL G Sbjct: 177 EMGIDEKVVEK-STGATDLPVLYAGGIASIKDVKRAKEAGAYGVVIGTALYHGDIDP 232 Score = 40.9 bits (95), Expect = 0.036, Method: Composition-based stats. Identities = 14/93 (15%), Positives = 25/93 (26%), Gaps = 3/93 (3%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 + + + D+ G N + +C Q GGI + Sbjct: 33 DPVETAHQWSEFFPW-IHVVDVDA-ARGEGDNSDIIGRICEE-VDAKVQVGGGIRSAERA 89 Query: 212 AALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 L G +IVG K + + + Sbjct: 90 EELIELGADRLIVGTVAFTDKDDFSKIVDVCHD 122 >UniRef50_B5YE89 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Dictyoglomus RepID=HIS4_DICT6 Length = 242 Score = 181 bits (461), Expect = 1e-44, Method: Composition-based stats. Identities = 76/247 (30%), Positives = 127/247 (51%), Gaps = 14/247 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +IIPA+D+ VVR+ G K N+PL + + +GA+ LHL+DL A D Sbjct: 2 LIIPAIDIYKHKVVRMETGKKEKIVLEFNNPLDLAKYWEEKGAKALHLIDLQSAIDANDE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 +++ +V V++PV+VGGG RS E + + GV RV+V S D + F ++ Sbjct: 62 SKSIVRDIVRSVSIPVEVGGGYRSREKIEEAISWGVWRVIVSSILGMELDYLLDLFSKY- 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + ++ ++D + +V + GWQ+ + + ++ V+ TDISRDGTL Sbjct: 121 ENKIIPSID-----WYDGKVGIKGWQDFIEWR--DIKRKIDLLKVREVIFTDISRDGTLK 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-----GVRGVIVGRALLEGKFTV 235 G N+ + + + + + GGI I+DV ++ ++G+I+GRALLEGK Sbjct: 174 GVNLENIKNFLSLHDYDVWIA-GGISSIEDVIKIKDLSENTGRIKGIIIGRALLEGKINW 232 Query: 236 KEAIACW 242 +EA Sbjct: 233 EEAKKII 239 >UniRef50_Q01ZU7 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Candidatus Solibacter usitatus Ellin6076 RepID=Q01ZU7_SOLUE Length = 227 Score = 180 bits (458), Expect = 3e-44, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 115/238 (48%), Gaps = 15/238 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MI+P +DL+DG VV+L QG ++ G+ P L+ + G + ++DL A Sbjct: 1 MIVPCIDLMDGKVVQLIQGR--EKALEGDSPDEMLRRF--AGFPEIQVIDLDAAL-GKGS 55 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L+K L + VGGGVR+ + LL G RV+VG++A + + E Sbjct: 56 NDTLVKMLASKAVCR--VGGGVRTLDRANTLLSQGAHRVIVGTSAFTKGGINVPFLETLD 113 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ALD + ++ V GWQE + + E+++ + P LCT + ++G + Sbjct: 114 PATTIVALDSK-----GGRIVVKGWQEATEFTAEEVLHSLEPY-CSGFLCTYVDKEGMMQ 167 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEA 238 G+++ + + A ++GGI ++D+ AL + VG A+ G+ ++E Sbjct: 168 GTDLDWFARLRA-ATAHEITAAGGITTLEDIKALLAMNIHTA-VGMAIYTGRLDLEEL 223 >UniRef50_D2NNQ2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase n=2 Tax=Rothia mucilaginosa RepID=D2NNQ2_9MICC Length = 262 Score = 179 bits (456), Expect = 6e-44, Method: Composition-based stats. Identities = 73/258 (28%), Positives = 119/258 (46%), Gaps = 19/258 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++PA+D+ +G VR G DP+ + GA +HLVDL A Sbjct: 8 LLPAVDISEGYAVRPVGGTLSGGEQRL-DPVEAALTWVKAGARWIHLVDLDLAF-GRGTN 65 Query: 62 IPLIKTLVAGV-----------NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 ++ +VA V V +QV GGVR+ E + L RV V S A+ Sbjct: 66 TEVLAEVVAAVRAENARMTGSAPVRIQVSGGVRNPESLERALSLNPDRVNVTSAALADSS 125 Query: 111 MVKGWFERF-GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVL 169 ++G R+ +D L L LD R + V V+ + SG + + + G++ + Sbjct: 126 WLEGTLARYADSDLLALGLDARYTPERGW-VTVARGTDWSGPGVAEALAWLEGAGVRRYI 184 Query: 170 CTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT---GVRGVIVGR 226 TD+S+DG+LAG L + V A+ +SGG+ + D+ LR G+ GV++G+ Sbjct: 185 VTDVSKDGSLAGPGAELLDVVLAQ-TDRPVVASGGVASLADLVKLRSMVPSGLEGVVLGK 243 Query: 227 ALLEGKFTVKEAIACWQN 244 AL G F+ ++A+ + Sbjct: 244 ALYVGNFSFEQALEIAGS 261 >UniRef50_Q1D4M2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=3 Tax=Bacteria RepID=HIS4_MYXXD Length = 238 Score = 178 bits (451), Expect = 2e-43, Method: Composition-based stats. Identities = 66/234 (28%), Positives = 112/234 (47%), Gaps = 7/234 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 + IPA+DL +G V+L G Y ++ +PL L+ + G H+VDL A Sbjct: 2 IAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSN 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + + + VGGGVR + V +L G VVVG+ A++ + RF Sbjct: 62 ADAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFP 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V+A DV+ ++V GW S + +++ + P+ L +L T + ++G L+ Sbjct: 122 G-RVVVAADVK-----GREVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKEGQLS 175 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 G ++ L EV A + +SGG+ ++D+ AL G G ++G AL G+ Sbjct: 176 GVDLPLMREV-ASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLD 228 >UniRef50_A0LAC8 Imidazole glycerol phosphate synthase subunit hisF n=1 Tax=Magnetococcus sp. MC-1 RepID=A0LAC8_MAGSM Length = 260 Score = 176 bits (448), Expect = 4e-43, Method: Composition-based stats. Identities = 45/213 (21%), Positives = 102/213 (47%), Gaps = 2/213 (0%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L L +G +V+ + + K Y DP+ + + + + L ++D++ ++ A+ Sbjct: 6 VIPTLLLKEGRLVKTVRFNQAKAT-YVGDPVNTAKIFNDKEVDELAVLDISASRRGAEPD 64 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 ++ L + +P+ GGGVR+ + + L +GV +V++ + +++ + +G+ Sbjct: 65 FECVEQLASECFMPLLYGGGVRNLQQIQRLFHSGVEKVMLNTAFFSGSGLLQEAVKIYGS 124 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +L +++DV+ D G +V G Q +G+ + G +L + +DG G Sbjct: 125 QSLGVSIDVKKDLWGRYRVMSQGGQRKTGLDPVVAAQQAEQAGAGELLLNAMDQDGMQQG 184 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL 214 ++ L + V +R + + GG + D + Sbjct: 185 YDLELVQRV-SRGVAIPVIAVGGAASVADFRTV 216 Score = 60.6 bits (146), Expect = 5e-08, Method: Composition-based stats. Identities = 15/93 (16%), Positives = 36/93 (38%), Gaps = 1/93 (1%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 + + + + DIS A + E++ + + GG+ ++ + Sbjct: 33 DPVNTAKIFNDKEVDELAVLDISASRRGAEPDFECVEQLASEC-FMPLLYGGGVRNLQQI 91 Query: 212 AALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 L +GV V++ A G ++EA+ + + Sbjct: 92 QRLFHSGVEKVMLNTAFFSGSGLLQEAVKIYGS 124 >UniRef50_A6Y2G9 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase 2 n=4 Tax=Vibrio RepID=A6Y2G9_VIBCH Length = 262 Score = 176 bits (446), Expect = 8e-43, Method: Composition-based stats. Identities = 60/249 (24%), Positives = 113/249 (45%), Gaps = 12/249 (4%) Query: 2 IIPALDLIDGTVVRLHQGD-----YGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 + P++D++ G + +++ Y + + + GA+ +H+VDL A Sbjct: 6 LYPSIDIVGGKALTSRSAIDITLGITEEKTYLGEVFEVAELHFQSGAKWIHIVDLDAA-S 64 Query: 57 PAKRQIPLIKTLVAGVNVPVQ--VGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 LI LV + VQ V GG+RS E + + AG +RV + S + + Sbjct: 65 GVGSNQRLIMDLVKHFSEKVQTQVCGGIRSNEILEQYILAGCSRVNISSMIFDKPKLCEK 124 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 +++G + + +ALDV++ ++A GW G +L ++ G + + TD+ Sbjct: 125 LLKKYG-EKIAIALDVKLV-NQEYKLATRGWNTLQG-NLWTTLDWLDNSGCQRYVLTDVD 181 Query: 175 RDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 R G+L N SL E+V + S GG+ +DD+ L G+ G ++G+ + + Sbjct: 182 RGGSLNHPNFSLLEQVLTK-TSTPIISGGGLCSLDDIDRLYQIGIEGAVLGQLIHTQQHQ 240 Query: 235 VKEAIACWQ 243 +K + Q Sbjct: 241 LKRFLQYVQ 249 >UniRef50_UPI000038E352 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E352 Length = 229 Score = 176 bits (446), Expect = 9e-43, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 110/243 (45%), Gaps = 18/243 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 I PA+D+ +G V L G K +G DP+ Q++++ + LH+VDL GA Sbjct: 4 IYPAIDIYNGEAVSLENGKIEKIESFG-DPVKFAQEFSSISGK-LHIVDLNGAFTGNPAN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LIK + V +Q GGG R+ E + A G+ +++G+ ++ +++ E+ Sbjct: 62 TNLIKNIRKNVKSFMQAGGGYRTMESIEAGYSLGIDSIIIGTASLDK-KILEEVSEKH-- 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D N + +GW + + +S + T I+ DGT Sbjct: 119 KNITISIDAY-----NGYIKYNGWADGTEISYRDFYSMVKGR-ANRFIFTAINSDGTG-- 170 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 + + + F +GG+ IDD+ L G G I+G+AL G ++E + C Sbjct: 171 ----HISRIEKFWDEGYFMYAGGVNSIDDLKKLENMGFNGAIIGKALYNGNIKIEE-LKC 225 Query: 242 WQN 244 QN Sbjct: 226 LQN 228 >UniRef50_A5INE5 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermotogaceae RepID=HIS4_THEP1 Length = 241 Score = 175 bits (445), Expect = 1e-42, Method: Composition-based stats. Identities = 66/249 (26%), Positives = 119/249 (47%), Gaps = 15/249 (6%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +++PA+DL G V R+ +G Y DP ++ +G ++H+VDL+ A + + Sbjct: 2 LVVPAIDLFRGKVARMVKGKKENTIFYEKDPAELVKKLIEEGFTLIHVVDLSKAIENSVE 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 P+++ L +Q+GGG+RS + L + G R +V S ++ +K + + Sbjct: 62 NFPVLERLSEFAE-HIQIGGGIRSFDYAERLRKLGYKRQIVSSKVLEDPSFLK-FLKEID 119 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + V +LD R +VA GW + L++ GL+ ++ T+I +DGTL Sbjct: 120 VEP-VFSLDTR-----GGKVAFKGWLAEEEIDPISLLKRLKEYGLEEIVHTEIEKDGTLQ 173 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG------VRGVIVGRALLEGKFT 234 + SL ++ +V ++GGI + + + ++GVIVGRA LEG T Sbjct: 174 EHDFSLTRKIAIEA-EVNVFAAGGISSENSLKTAQRVHRETNGLLKGVIVGRAFLEGILT 232 Query: 235 VKEAIACWQ 243 V+ + Sbjct: 233 VEVMKRYAR 241 >UniRef50_B9U3E3 HisA n=1 Tax=Taylorella equigenitalis RepID=B9U3E3_9BURK Length = 251 Score = 174 bits (443), Expect = 2e-42, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 116/253 (45%), Gaps = 17/253 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLV--DLTGAKDPA- 58 IIP++ + DG V + GD + DPL + +A GA+ LH+V L + A Sbjct: 3 IIPSIYIQDGKCVHVSYGDKTSSSPFEIDPLDLAKKWADLGADRLHIVQLGLNASTQNAT 62 Query: 59 --KRQIPLIKTLVAGVN--VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + ++ L+ V+ +P+Q+ GG+++ + + L+ G VVVGS VK + Sbjct: 63 SLSKNNEVLSKLIEEVSHYLPLQIAGGIKTMASIESYLDMGFDFVVVGSAGVKDPHFMND 122 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 F ++L LD R + +V W + + + + G+ ++ TD+ Sbjct: 123 ACSAFNGQ-VILGLDAR-----DGKVVTDSWSKVTKFDAVTIAQRLTDEGIDSIIYTDMG 176 Query: 175 RDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDID---DVAALRGTGVRGVIVGRALLEG 231 DG + N+ A+ V + G +G + ++ L GV G+I+G++L G Sbjct: 177 PDGNMTEVNLEATLNF-AKAVDVPVLACGDVGQLSRFHEIKTLVDHGVDGIILGKSLDLG 235 Query: 232 KFTVKEAIACWQN 244 ++++EAI + Sbjct: 236 VYSLQEAIDIVDS 248 >UniRef50_C7H029 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=Eubacterium saphenum ATCC 49989 RepID=C7H029_9FIRM Length = 250 Score = 174 bits (442), Expect = 2e-42, Method: Composition-based stats. Identities = 48/244 (19%), Positives = 108/244 (44%), Gaps = 6/244 (2%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 +I+P +D+ G VV+ + + +D DP+ + Y A GA++L D+ + + + Sbjct: 4 LIMPCMDIRHGKVVKGIK--FEGVKDVA-DPVELAKYYDATGADILVFYDIAASVEDKQI 60 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 L K++ A ++P+ GGG+++ EDV +++ G V + + A+ + D++ E+ G Sbjct: 61 YEGLFKSVRAVSDLPLVAGGGLKTIEDVDNIIKLGADMVSINTGAIDNPDLLNEAAEKIG 120 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ ++L++D + G V + ++G+ + + G ++ I DG A Sbjct: 121 SENVILSVDAKKV-NGEYHVFRNAGMMDTGLDALEWISEGYDRGAGILVLNSIDTDGVKA 179 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAI 239 G ++ + + +SGG G + D V + + + + Sbjct: 180 GYDIEMLKA-AGEVTDAKIVASGGAGKMQDFKEALMLPKVEVALAASVFHYKEIVIDDLK 238 Query: 240 ACWQ 243 + Sbjct: 239 EYLR 242 >UniRef50_Q7MPK7 Putative imidazole glycerol phosphate synthase subunit hisF3 n=18 Tax=cellular organisms RepID=HIS63_VIBVY Length = 260 Score = 174 bits (441), Expect = 3e-42, Method: Composition-based stats. Identities = 54/236 (22%), Positives = 107/236 (45%), Gaps = 7/236 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L + + +V+ + K+ Y DPL ++ + Q A+ L L+D+ ++ + Sbjct: 11 VIPVLLMREKGLVKTVK---FKEGKYVGDPLNAVKIFNEQEADELTLLDIDASRLGHEPD 67 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 LI+ + + +P+ GGG+++ E +L+ GV +V + S ++ ++ ER G Sbjct: 68 YVLIERIASECRMPLCYGGGIKTVEQAERILKLGVEKVSLSSAVFENPKIITQLAERVGR 127 Query: 122 DALVLALDVRIDEQG-NKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++V+ LDV+ G + V + V+ +G ++ I DG + Sbjct: 128 QSIVVCLDVKKRLFGSKFDCFTINGTKKQSVDTIEFVKQIQTLGAGEIVLNFIDNDGVMK 187 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRAL-LEGKFT 234 G ++ + A +V GG G +DD+A L + + G G +GK+ Sbjct: 188 GYDLDAVSKFKA-LVKVPLTVVGGAGCVDDIAKLVQQEKLVGAAAGSLFVFKGKYK 242 >UniRef50_C0BNI2 Histidine biosynthesis protein n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BNI2_9BACT Length = 248 Score = 173 bits (438), Expect = 6e-42, Method: Composition-based stats. Identities = 49/244 (20%), Positives = 110/244 (45%), Gaps = 11/244 (4%) Query: 2 IIPALDLIDGT-VVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIP + +G +V+ + R G +P+ + + ++G + L +D+ K K Sbjct: 6 IIP-ILTFNGLGLVKTKG--FKNPRMVG-NPVQTARVFNSRGVDELIFLDIYATKQSRKI 61 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + L+K ++ +PV +GGG+++ + + LL+ G +VV+ S A+ + +K FG Sbjct: 62 NLSLVKEVIKECYMPVSIGGGIQTIDQINDLLKIGADKVVIKSKALTDKKFLKEAINFFG 121 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + + +++DV N + + +SLE+ + + +L ++ DG + Sbjct: 122 SQCICISVDVLFVNN-NYLIYNDLGLK---ISLEEFITEMSLINAGELLVNSVNNDGVMN 177 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVKEAI 239 G ++ L +V + + ++GG G+ + + L T + V ++T + Sbjct: 178 GFDIDLINKV-EQMTTIPVIAAGGGGEPEHYSTLFNKTKINAVASSSIFHFTQYTPLDIK 236 Query: 240 ACWQ 243 + Sbjct: 237 NELK 240 >UniRef50_C5E2I9 KLTH0H05368p n=17 Tax=cellular organisms RepID=C5E2I9_LACTC Length = 550 Score = 173 bits (438), Expect = 6e-42, Method: Composition-based stats. Identities = 57/305 (18%), Positives = 112/305 (36%), Gaps = 62/305 (20%) Query: 2 IIPALDLI---DGTVVRLHQGDYG-KQRDYGND------PLPRLQDYAAQGAEVLHLVDL 51 II LD+ G +V Y +++ G + P+ Q Y QGA+ + +++ Sbjct: 238 IIACLDVRTNDQGDLVVTKGDQYDVREKQEGGNVRNLGKPVELAQKYYEQGADEVTFLNI 297 Query: 52 TGAKD---PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA-----------ALLEAGVA 97 T +D + ++K V VP+ VGGG++ DV +G Sbjct: 298 TSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTHIPALQVAALYFASGAD 357 Query: 98 RVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRID----------- 133 +V +GS AV + + ++ + +GA A+V+++D + Sbjct: 358 KVSIGSDAVYAAEKYYELGERGDGASPIETISKSYGAQAVVISVDPKRVYVDGPESVKHK 417 Query: 134 ------------EQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 Q + G +E+ + + +L +G VL I +DG+ +G Sbjct: 418 TFETKFPNEKGQTWCWYQCTIKGGRESRDMGVWELTRACEALGAGEVLLNCIDKDGSNSG 477 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRG-TGVRGVIVGRALLEGKFTVKEAIA 240 ++ L ++ +S G G+ TG + G++TV + Sbjct: 478 YDLELINH-AKEAVKIPVIASSGAGEPKHFKEAFESTGADACLGAGMFHRGEYTVNDVKQ 536 Query: 241 CWQNA 245 ++ Sbjct: 537 YLLDS 541 >UniRef50_C7RAI7 Phosphoribosyl-ATP diphosphatase n=1 Tax=Kangiella koreensis DSM 16069 RepID=C7RAI7_KANKD Length = 412 Score = 172 bits (436), Expect = 1e-41, Method: Composition-based stats. Identities = 56/244 (22%), Positives = 115/244 (47%), Gaps = 19/244 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IP++DL+DG V+L QGD ++ ++ L++++ G + ++DL A Sbjct: 1 MLIPSIDLLDGKAVQLQQGDASRKIVEKDNLFELLEEFSLFG--EVAIIDLNAAL-GKGD 57 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 LIK L+ + VGGG+R+ E L +G ++++G++ + + ++ Sbjct: 58 NKALIKQLIKKFSCR--VGGGIRNYETAREYLSSGAKKIILGTSCR------EDFVKKLP 109 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 L+ A+D + D+ GWQ +S + +++ L T + ++G + Sbjct: 110 RSQLIFAIDAKGDDW-----VTHGWQSSSDNKVAAMIDELQD-NCSEFLYTQVEKEGMMQ 163 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIA 240 G + E+V + ++ +GGI D+DD+ + G + G ++ GK + EA+ Sbjct: 164 GIDRERIEQVIKQ-SKIQVTVAGGITDLDDIKFINKLGANSQL-GMSIYTGKLKLDEAVM 221 Query: 241 CWQN 244 + Sbjct: 222 ACLD 225 >UniRef50_P33734 Cyclase n=51 Tax=cellular organisms RepID=HIS5_YEAST Length = 552 Score = 170 bits (432), Expect = 4e-41, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 114/303 (37%), Gaps = 64/303 (21%) Query: 2 IIPALDLI---DGTVVRLHQGDYGKQRDYGN--------DPLPRLQDYAAQGAEVLHLVD 50 II LD+ G +V + +GD R+ + P+ Q Y QGA+ + ++ Sbjct: 240 IIACLDVRTNDQGDLV-VTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVTFLN 298 Query: 51 LTGAKD---PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVA-----------ALLEAGV 96 +T +D + ++K V VP+ VGGG++ DV +G Sbjct: 299 ITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGA 358 Query: 97 ARVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRI----------- 132 +V +G+ AV + + ++ + +GA A+V+++D + Sbjct: 359 DKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKN 418 Query: 133 ------------DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++ Q + G +E+ + + +L +G +L I +DG+ + Sbjct: 419 KVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDGSNS 478 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVKEAI 239 G ++ L E V ++ +S G G + T + G+FTV + Sbjct: 479 GYDLELIEHV-KDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVNDVK 537 Query: 240 ACW 242 Sbjct: 538 EYL 540 >UniRef50_C4R8P0 Imidazole glycerol phosphate synthase (Glutamine amidotransferase:cyclase) n=8 Tax=Saccharomycetales RepID=C4R8P0_PICPG Length = 561 Score = 169 bits (429), Expect = 7e-41, Method: Composition-based stats. Identities = 54/302 (17%), Positives = 108/302 (35%), Gaps = 62/302 (20%) Query: 2 IIPALDLI---DGTVVRLHQGDYG-KQRDYGND------PLPRLQDYAAQGAEVLHLVDL 51 II LD+ G +V Y +++ D P+ + Y QGA+ + +++ Sbjct: 250 IIACLDVRTNDSGDLVVTKGDQYDVREKSESGDVRNLGKPVEMAEKYYQQGADEVTFLNI 309 Query: 52 TGAKD---PAKRQIPLIKTLVAGVNVPVQVGGGVRSEED-----------VAALLEAGVA 97 T ++ + ++K V VP+ VGGG++ D AG Sbjct: 310 TSFRNSPIKDAPMLEVLKRAAETVFVPLTVGGGIKDVVDPDGTKVPALKVATLYFRAGAD 369 Query: 98 RVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRIDEQGN------- 137 +V +G+ AV + + ++ +G A+V+++D + + Sbjct: 370 KVSIGTDAVLAAEEFYRNNEKGTGLTPIETISASYGVQAVVISVDPKRFYVADPSKTPYK 429 Query: 138 ----------------KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V G + + +L +G +LC I +DG+ +G Sbjct: 430 TIKTKFPGPNGENYCYYKVTSQGGRNVHDLGAWELCYACEKLGAGEILCNCIDKDGSNSG 489 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKEAIA 240 ++ L + + ++ +S G G+ R T + G++TVKE Sbjct: 490 YDLELIDYI-KSATKLPVIASSGAGNPSHFEEVFRKTETDAALGAGMFHRGEYTVKEVKD 548 Query: 241 CW 242 Sbjct: 549 FL 550 >UniRef50_D2L5A7 Histidine biosynthesis protein n=1 Tax=Desulfovibrio sp. FW1012B RepID=D2L5A7_9DELT Length = 261 Score = 167 bits (424), Expect = 3e-40, Method: Composition-based stats. Identities = 54/212 (25%), Positives = 90/212 (42%), Gaps = 5/212 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP + + G VV+ + + G P ++ + + + L+ + D R Sbjct: 6 LIPVVLVKQGLVVQSIG--FRRYLPVGR-PKITVEFFNRWDCDEIVLLAIDREPDL-ARL 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L + VP+ VGGGVR ED LL AG +V + + A + +++ E FG Sbjct: 62 AGLTAHVSGAAFVPLTVGGGVRRIEDFQELLRAGADKVSLNTAAFRDPELITRAAEAFGN 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V+++D R G +V V G +E +G G +L I RDG G Sbjct: 122 QEVVVSIDARRHADGRYEVFVGGGREATGADPRDFAREAERRGAGEILLNAIDRDGGKQG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 ++ L V A + + GG+G I+ V Sbjct: 182 YDLELVRRV-ATAVSIPVIALGGVGRIEHVPE 212 >UniRef50_A3UE29 HisF (Cyclase) n=1 Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UE29_9RHOB Length = 261 Score = 166 bits (421), Expect = 7e-40, Method: Composition-based stats. Identities = 49/223 (21%), Positives = 100/223 (44%), Gaps = 16/223 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTG----AKDP 57 +IP L L++G +VR + + G DPL + + + L +D++ A+ Sbjct: 6 LIPVLLLMNGQLVR--SETFTTHQIIG-DPLHEVARFNEWKVDELIYLDISRTAGLAQGR 62 Query: 58 AKR-------QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 + +++ + + +P+ GG V S + V + + G +V + + A ++ D Sbjct: 63 RDAGNRAYADAMDVLEAVASHCFMPLTWGGHVTSLDQVRDIFKRGADKVAINTAAYETPD 122 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 ++ +RFGA A+V+++D R E G +V G + +G + G +L Sbjct: 123 LITQVSKRFGAQAMVVSIDARQIENG-YEVMTQGGRTATGRDPVSWAKEAEDRGAGEILL 181 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 + RDG G + +L E+V ++ + + G+G + A Sbjct: 182 QSLDRDGRGTGYDTTLIEQV-SQAVTIPVIACSGVGVYEHYAK 223 >UniRef50_Q6KZD4 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Picrophilus torridus RepID=Q6KZD4_PICTO Length = 222 Score = 166 bits (420), Expect = 9e-40, Method: Composition-based stats. Identities = 64/242 (26%), Positives = 106/242 (43%), Gaps = 26/242 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ +G V L G + + YG DP+ + + LH++DL GA + ++ Sbjct: 4 VYPAIDIYNGRAVFLENGRLERIKVYG-DPVYYALRFQEY-FDFLHVIDLNGAIENKRKN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +IK ++ V VQVGGG+R+ DV + + G ++G+ D Sbjct: 62 RDVIKNIIKEVKAKVQVGGGLRTLNDVIDVYDFGAYSAIIGTNIDIEVD----------- 110 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + L++DV D +VA GW + + + T+I DGT Sbjct: 111 KNVTLSIDVYKD-----RVANRGWLNITDNDPVSFYKMLKNR-FSRFIYTNIGSDGTN-- 162 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKEAIAC 241 N + E+ + F +GG+ I+DV G G+I+GRAL E + E + C Sbjct: 163 -NSGIPEKF---WDNEYFIYAGGVSGINDVKKALKNGFSGIIIGRALYENRIDPGE-LKC 217 Query: 242 WQ 243 Q Sbjct: 218 LQ 219 >UniRef50_Q2N6D2 Imidazoleglycerol-phosphate synthase, cyclase subunit n=1 Tax=Erythrobacter litoralis HTCC2594 RepID=Q2N6D2_ERYLH Length = 264 Score = 165 bits (419), Expect = 1e-39, Method: Composition-based stats. Identities = 53/213 (24%), Positives = 99/213 (46%), Gaps = 5/213 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP L L + V+ HQ + Y D + Q + ++ A+ L +VD+ G + Sbjct: 6 IIPVLLLDGTSAVKTHQFKPAR---YIGDIVNAAQIFNSKMADELIVVDI-GYHQDNPSR 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +I+ L +P+ GGG+ S ++ AAL + G+ +V + + V+ +V+ +FG+ Sbjct: 62 PEVIRHLAEECFMPLAFGGGISSVDEAAALFKDGIEKVSINTAFVEGGALVEEAARQFGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ++V ++D R + G+ QV G G+ ++ G +L I RDG G Sbjct: 122 QSVVASIDARREADGSYQVYSRGGTRALGIDPVEMARRAEAQGAGEILIQSIDRDGMRKG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL 214 + +L + + + GG +DD+A + Sbjct: 182 YDRNLVRSIV-DATTLPVVALGGADTVDDLAQV 213 >UniRef50_Q8ZY14 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=5 Tax=Thermoproteaceae RepID=HIS4_PYRAE Length = 229 Score = 165 bits (419), Expect = 1e-39, Method: Composition-based stats. Identities = 68/235 (28%), Positives = 105/235 (44%), Gaps = 13/235 (5%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 MIIP++D+ G V+ +G G + DPL + A ++H+VDL GA+ Sbjct: 1 MIIPSIDIEGGRAVKRIRGQRGNY-IFQGDPLELAARFRK--APLVHVVDLDGAEAGGLV 57 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I +I + + ++GGG+RS E V L VVGS K+ + + E + Sbjct: 58 NISVISKIAEILEGRCELGGGLRSLEAVERALSL-CQYAVVGSLPFKNWPLFRRAAELY- 115 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGL-KHVLCTDISRDGTL 179 D L ++LD R +V V GW+E + S+ + V G V+ T + +GT Sbjct: 116 RDRLAVSLDYR-----GGEVLVGGWREKAA-SIAEAVRRLEEAGPYAAVIVTSVEVEGTG 169 Query: 180 AGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFT 234 G + + R + +GG+ D +DV G GVIVG AL G Sbjct: 170 GGVKADIDVKSLKRIAR-RVFYAGGVRDCNDVERAYALGFDGVIVGYALYAGDLK 223 >UniRef50_A4YI32 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Metallosphaera sedula DSM 5348 RepID=A4YI32_METS5 Length = 228 Score = 164 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 107/232 (46%), Gaps = 12/232 (5%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P++D+ G V+ +G G G DPL ++ G +HLVDL A + Sbjct: 3 VVPSIDISKGMAVKRVRGREGTGLVLG-DPLKIAEELRNMGYTSVHLVDLDAA-EGKGDN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + +I+ ++ + + VGGG+R + L +G +VV+ + A D + + Sbjct: 61 VEVIERVMKDFS-EISVGGGIRDRSRLERFLSSGATKVVMSTLAFTKPDTFRRVVAGY-E 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++++D ++V + GW E S +S E+ + +G++ V+ T + +GT G Sbjct: 119 NRVLVSVDY-----CERKVLIKGWNE-SAMSFEEAISHVNSLGVRGVIFTYVCNEGTRNG 172 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + + V Q +GGIG I D+ L G IVG +L G Sbjct: 173 IDPEIGRYV--NLVQGEKGYAGGIGSIQDLQELDKMGFHFAIVGMSLYAGVL 222 >UniRef50_C9YDK8 Imidazole glycerol phosphate synthase subunit hisF n=2 Tax=Bacteria RepID=C9YDK8_9BURK Length = 286 Score = 164 bits (416), Expect = 2e-39, Method: Composition-based stats. Identities = 48/211 (22%), Positives = 83/211 (39%), Gaps = 6/211 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRL-QDYAAQGAEVLHLVDLTGAKDPAKR 60 +IP L +V+ + R G P+ + Y + + L LVD+ + Sbjct: 32 VIPTLLWKHFGLVKGVG--FNSWRRVG--PVLPAIKVYNQREVDELVLVDILAHGRGEEP 87 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 I VP+ VGGG+ E V LL G +V + + A ++V R G Sbjct: 88 DYESIHEFGQDCFVPLTVGGGITHIEQVQRLLRVGADKVSLNTAAYARPELVSDIARRHG 147 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 +V ++DVR G + +G + G +L T I DG++ Sbjct: 148 VQCVVASIDVRPRAGGGWDCFSHAGTQPTGRDVVAWARELEDRGAGEILVTSIDLDGSMR 207 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 G +++L A+ ++ +SGG G+ + Sbjct: 208 GYDLALVAA-VAQAVKIPVIASGGAGNYQHM 237 >UniRef50_UPI0001C41F9C hisA/hisF family protein HisAF n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C41F9C Length = 231 Score = 164 bits (415), Expect = 3e-39, Method: Composition-based stats. Identities = 57/241 (23%), Positives = 106/241 (43%), Gaps = 21/241 (8%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL++ V G+ +DPL + GA+ +++ DL + Sbjct: 4 IIPVIDLMNSVAVSGKSGNRETYTPLQTIYASSSDPLEIALSLKSAGAKEMYIADLDFIE 63 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 I IK + + +PV + GV E LLE +++V + ++S + + Sbjct: 64 RNGNNNIFKIKEVNSV--LPVILDVGVDKLETFEFLLEF-AYKIIVATETLESIEELGKI 120 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 FE++ + +++++DV+ +E + +N + LE E + ++ DIS Sbjct: 121 FEKYPKERIIVSVDVKNNEL---------YAKNMDLDLEGFKEVLRRIDPNEIILLDISS 171 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 GT G N L E ++ GGI D+++ L G+R +VG AL +G+ + Sbjct: 172 VGTEGGFNKPLLESFEEFKDKI--ILGGGI-TPDEISQLDALGIRKALVGTALHKGQIRL 228 Query: 236 K 236 Sbjct: 229 N 229 >UniRef50_B9WJS1 Imidazole glycerol phosphate synthase [includes: glutamine amidotransferase; cyclase], putative n=6 Tax=cellular organisms RepID=B9WJS1_CANDC Length = 622 Score = 163 bits (413), Expect = 6e-39, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 112/318 (35%), Gaps = 78/318 (24%) Query: 2 IIPALDLI---DGTVVRLHQGDYGKQR----------------DYGNDPLPRLQDYAAQG 42 II LD+ DG +V + +GD R P+ Y QG Sbjct: 292 IIACLDVRTNDDGDLV-VTKGDQYNVREQQSSSSKISENSNQVRNLGKPVELATKYYNQG 350 Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTL---VAGVNVPVQVGGGVRSEED------------ 87 A+ + +++T ++ + +P+++ L + VP+ VGGG++ D Sbjct: 351 ADEITFLNITSFRNSPLKDLPMLQVLRKSAETIFVPLTVGGGIKDLYDSETKKIIPAVDI 410 Query: 88 VAALLEAGVARVVVGSTAVKSQD-------------MVKGWFERFGADALVLALDVRIDE 134 ++G ++ +GS AV + ++ +FG A+V+++D + Sbjct: 411 AHLYFQSGADKISIGSDAVIIAENYYANNQIPLGTSSIETISSKFGNQAVVISVDPKRKY 470 Query: 135 QGN---------------------------KQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 N QV G ++ + +L +G Sbjct: 471 IKNPQLDTTMETIKIIDPLQYGPNGEQYCYYQVTSQGGRKLHELGALELCLACEKLGAGE 530 Query: 168 VLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT--GVRGVIVG 225 +L I DG+ G N+ L +++ + + +S G G+ + G+ + Sbjct: 531 ILLNSIDNDGSNKGFNLQLLQQI-KSHVSIPVIASSGAGNPQHFQQVFEMDCGIDAALGA 589 Query: 226 RALLEGKFTVKEAIACWQ 243 G++TV E Q Sbjct: 590 GIFHRGEYTVNEVKKYLQ 607 >UniRef50_O33772 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=10 Tax=Sulfolobus RepID=HIS4_SULSO Length = 232 Score = 163 bits (413), Expect = 6e-39, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 105/232 (45%), Gaps = 9/232 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIP++D+ G V+ +G G G +P+ +G +H+VDL A + Sbjct: 4 IIPSIDISFGKAVKRIRGVRGTGLVLG-NPIELANKLYNEGYSRIHVVDLDAA-EGVGNN 61 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 IK + +QVGGG+R E L+ V ++ + + ++ G Sbjct: 62 EMYIKEICKIGFDWIQVGGGIRDVEKAKRLISLDVNALIFSTIVFTNFNLFYNIVREIGN 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++++D K+V +SGW+E S + + ++ + L ++ T ++ +GT+ G Sbjct: 122 NRVIVSIDY----DDTKRVLISGWKERS-MEIIDGIKKVNELELLGIILTYVTNEGTVKG 176 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + S+ + A+ + + +GG+ D+ L+ G +IVG A K Sbjct: 177 IDYSV--KDYAKLIRGVKEYAGGVSSDSDITFLKNVGFDYIIVGMAFYLNKI 226 >UniRef50_Q1N2Y7 HisF protein n=1 Tax=Bermanella marisrubri RepID=Q1N2Y7_9GAMM Length = 223 Score = 163 bits (413), Expect = 6e-39, Method: Composition-based stats. Identities = 47/214 (21%), Positives = 93/214 (43%), Gaps = 6/214 (2%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDV 88 D + ++ ++++ A+ + +VD+ + +PL+K L + +P+ +GGGV + ED Sbjct: 3 GDAITNVKVFSSRKADEMVIVDIEATEKKR-INLPLLKRLSSHCIMPLTIGGGVTTLEDA 61 Query: 89 AALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQEN 148 L G +V+V S +++ +FG A+V +LDV Sbjct: 62 EDLFSVGADKVLVNSAFYNRPEILTDISSKFGRQAVVFSLDVMKKSN-EYVPVSKNGSVK 120 Query: 149 SGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDI 208 +L + VE + G ++ + DG + G +++L ++V + V +GG G Sbjct: 121 QSWTLRETVERAIEYGAGEIILNSVDCDGMMQGFDLNLCKQV-SDISSVPVVIAGGCGTK 179 Query: 209 DDVAALRGTGVRGVIVGRALL---EGKFTVKEAI 239 +D +G V G E T+K+ + Sbjct: 180 EDCVLAVNSGADAVAAGSIFYWVGESILTIKDYM 213 >UniRef50_A7SPR8 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SPR8_NEMVE Length = 545 Score = 163 bits (412), Expect = 7e-39, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 102/277 (36%), Gaps = 62/277 (22%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIK---TLVAGVNVPVQVGGGVRS- 84 DP+ + + + GA+ + +++T + + ++K + VP VGGG+R Sbjct: 263 GDPVELGERFFSDGADEIAFLNITSFRSSPIHDLAMLKLLRKCCERIFVPFTVGGGIRDI 322 Query: 85 --------------------EEDVAALLEAGVARVVVGSTAVKSQDM------------- 111 E A ++G +V V S AV + + Sbjct: 323 YALDPDSVEEGKPVMRQFSALEVAAMYFKSGADKVSVASDAVYAAEEFIASGHKKTGKTS 382 Query: 112 VKGWFERFGADALVLALDVR-----------------------IDEQGNKQVAVSGWQEN 148 ++ ER+G A+VLA+D + ++ Q V G +E Sbjct: 383 IEKIAERYGRQAVVLAVDTKTVYVPSPDSTKHHTVKARYPGPNGEKYVWWQCTVKGGRET 442 Query: 149 SGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDI 208 V +LV+ +G +L +I RDGT G ++ L + V + +S G G + Sbjct: 443 RDVGAYELVKACEELGAGEILLNNIDRDGTNHGYDLDLVKMV-KGAVSIPVIASSGAGHV 501 Query: 209 DDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 D L R T G + G G+ + + +N Sbjct: 502 SDFVDLFRETNADGAMAGAIFHRGEVDITDVKEHLRN 538 >UniRef50_B6BR00 Imidazole glycerol phosphate synthase subunit HisF n=1 Tax=Candidatus Pelagibacter sp. HTCC7211 RepID=B6BR00_9RICK Length = 254 Score = 162 bits (411), Expect = 9e-39, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 93/221 (42%), Gaps = 5/221 (2%) Query: 16 LHQGD-YGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNV 74 L +G+ + ++ PL ++ Y ++ + + D+ +++ I ++ V+V Sbjct: 17 LVKGNKFENEKRSAGSPLTTVKIYNSRDVDEILFFDI--SRNNKIIDKDFILSITDCVSV 74 Query: 75 PVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDE 134 P+ +GGG+ + L E G +V + S K+ +++ +RFG+ A+ +++DVR + Sbjct: 75 PITIGGGIEKISQMNDLFEYGADKVAINSIIYKNPNIIDEASKRFGSQAITVSIDVRKN- 133 Query: 135 QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARY 194 N + + S L L+ + G ++ I+ DG + G + L ++ + Sbjct: 134 NQNYECYYDLGKIKSDRKLNDLLVECVNRGAGEIVINCINNDGLMKGYDNELIQQ-TSSL 192 Query: 195 PQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 + +SGG G + G + T Sbjct: 193 ANIPIVASGGAGSYEHFYEAYKNGADAFAAASIYHFTEHTP 233 >UniRef50_C6XVQ0 Histidine biosynthesis protein n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6XVQ0_PEDHD Length = 288 Score = 162 bits (411), Expect = 1e-38, Method: Composition-based stats. Identities = 47/253 (18%), Positives = 98/253 (38%), Gaps = 20/253 (7%) Query: 8 LIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKT 67 + DG VV+ + K G P ++ G + + L D++ + + +I+ Sbjct: 12 VKDGIVVQSIG--FKKYLPVGK-PEIAIEFLNQWGIDEIILTDISATRKQSGPDFDMIRR 68 Query: 68 LVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLA 127 VP+ VGGG+ + + LL G ++ + + A+ + +++ FG +V++ Sbjct: 69 AAQKCFVPLTVGGGISNTGQMKELLHNGADKISLNNAAITTPELITETAHIFGGQCVVIS 128 Query: 128 LDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLY 187 +D I ++ +S + + G +L + RDG+ G + L Sbjct: 129 IDG-IHTNKGFRIYDYLTHSALDISPSEFAKRAEDSGAGEILINSVDRDGSYLGFDHELI 187 Query: 188 EEVCARYPQVAFQSSGGIGDIDDVAALRGTGV--------------RGVIVGRALLEGKF 233 VC+ + GG + D + V + +++L K Sbjct: 188 NSVCS-VVNIPVIVCGGAKNAGDFIEVFSKTNASAATAANFFHFSEHSVNITKSILNKKM 246 Query: 234 TVK-EAIACWQNA 245 V+ EA A +++A Sbjct: 247 DVRSEAFANYEDA 259 >UniRef50_Q3JEF8 Histidine biosynthesis n=2 Tax=Nitrosococcus oceani RepID=Q3JEF8_NITOC Length = 235 Score = 161 bits (408), Expect = 2e-38, Method: Composition-based stats. Identities = 50/250 (20%), Positives = 90/250 (36%), Gaps = 26/250 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN------DPLPRLQDYAAQG-AEVLHLVDLTGA 54 ++P LDL G VV G + PL + + L++ DL Sbjct: 3 LLPVLDLWGGVVVHARGGQRDSYLPLNSPFAPNSSPLQVVAGLLQWCRFQQLYIADLNAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + + ++ + V GG E VA L GVAR VVG+ + + Sbjct: 63 MGDGNNHFMIAAIARSYPDLELWVDGGTARHEAVAQLFALGVARPVVGTETLPDLESW-Q 121 Query: 115 WFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDIS 174 + + L L++D R ++ + V+ + Sbjct: 122 ALQSSWPEQLALSMDHRRGAFLGP----------------AGLDRQPELWPGTVIAMSLD 165 Query: 175 RDGTLAGSNVSLYEEVCARY--PQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 + G+ G + SL E + R +++ ++GG+ ++D+ L GV GV++ AL +G Sbjct: 166 QIGSQQGPDWSLLERLGQRSLRKRISLLAAGGVRCLEDLKQLAAWGVEGVLLASALHDGS 225 Query: 233 FTVKEAIACW 242 E Sbjct: 226 LNPAELQQML 235 >UniRef50_C7GBG4 Imidazoleglycerol phosphate synthase, cyclase subunit n=2 Tax=Roseburia RepID=C7GBG4_9FIRM Length = 252 Score = 160 bits (405), Expect = 4e-38, Method: Composition-based stats. Identities = 53/242 (21%), Positives = 95/242 (39%), Gaps = 6/242 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L V L +G + LP ++ Y + + L L+D+ + Sbjct: 6 VIPTLLYKS---VGLVKGVGFNSWRRVDTVLPAIKVYNMREVDELILLDIEATNEKRDPD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 I+ VP VGGG+ + + LL AG +V + S A + ++ + FG+ Sbjct: 63 YDEIRDFSRECFVPFCVGGGICHIDQIKNLLRAGADKVAINSAAYDNLSLITEGAKLFGS 122 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V ++D R G ++G L+ + + G +L T + DGT+ G Sbjct: 123 QCIVASIDCRKI-DGEYHCFSHNGSVDTGWLLQDWIIKVVEAGAGEILLTSVELDGTMEG 181 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAAL-RGTGVRGVIVGRALLEGKFTVKEAIA 240 +V + ++ V +SGG G+ + + + G V + T KEA Sbjct: 182 YDVEMI-KIATSLVNVPVIASGGAGNYEHMRKAVQEGGASAVAAASIYHFTEQTPKEAKE 240 Query: 241 CW 242 Sbjct: 241 YL 242 >UniRef50_Q2NEW9 Putative uncharacterized protein n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEW9_METST Length = 239 Score = 159 bits (402), Expect = 9e-38, Method: Composition-based stats. Identities = 51/248 (20%), Positives = 105/248 (42%), Gaps = 18/248 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQR----DYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 MIIP +D++ V G + YG++PL GA+++++ DL + Sbjct: 4 MIIPVIDIMHNECVSGKSGRRSTYKKLRSIYGDNPLDIATALKEDGAQLIYIADLDKIER 63 Query: 57 PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 +PV + G+ S ED+ + + ++ + + S D ++ F Sbjct: 64 IDDNNN---IISSINNIIPVMLDNGISSIEDIEN-NKNICSYNILATETMTSLDNIEEIF 119 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 +++ ++ LV+++D++ +E N + LE ++ K+ + +IS Sbjct: 120 KKYDSNKLVVSIDIKNNELL---------VNNKDIDLEDVIYLINKYKPKYTIILNISYV 170 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 GT G N ++ EE+ + P +GGI + D+ + ++G L EG + K Sbjct: 171 GTKKGVNTNIIEEITKKIPHTKCCIAGGIRN-SDIETYTKKNINNFLIGTLLHEGNLSYK 229 Query: 237 EAIACWQN 244 + +N Sbjct: 230 LYMESKKN 237 >UniRef50_C7LZ82 Histidine biosynthesis protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7LZ82_ACIFD Length = 246 Score = 158 bits (400), Expect = 2e-37, Method: Composition-based stats. Identities = 85/248 (34%), Positives = 127/248 (51%), Gaps = 17/248 (6%) Query: 5 ALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR-QIP 63 A+DL+DG VRL QG + R +G DP ++ GA H+VDL A+ P R Sbjct: 6 AVDLLDGEAVRLRQGRFDAPRRFG-DPRRYVEGALDAGARWFHVVDLDRARTPGDRRNAD 64 Query: 64 LIK---TLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 ++ LV V+VGGGVR+ D+A LLE G +RVV+G+ +V+ + Sbjct: 65 MVGDLIALVREAGGSVEVGGGVRTARDIAELLETGASRVVLGTA------LVEETLDELD 118 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 + LV ALD R ++G +V VS W+ + G L + G++ L TD+ RDG + Sbjct: 119 PEHLVAALDYRRGDEGALEVVVSAWERSGGRRLLEASARLFARGVRTQLLTDVGRDGMAS 178 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG-----VRGVIVGRALLEGKFTV 235 G ++ Y+ +C P V +SGG+ DD+A L V G +VG ALL+G Sbjct: 179 GPDLGTYQGLCEVVP-VEVIASGGVASADDLAKLAAIRGARGAVWGAVVGTALLDGSLGF 237 Query: 236 KEAIACWQ 243 EA++ + Sbjct: 238 DEALSACR 245 >UniRef50_C1FJN8 Predicted protein n=13 Tax=cellular organisms RepID=C1FJN8_9CHLO Length = 601 Score = 156 bits (394), Expect = 9e-37, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 107/303 (35%), Gaps = 62/303 (20%) Query: 2 IIPALDLID---GTVVRLHQGDYG-KQRDYGND------PLPRLQDYAAQGAEVLHLVDL 51 +I LD+ G +V Y +++D GND P+ Y QGA+ + +++ Sbjct: 287 VIACLDVRSNDAGDLVVTKGDSYDVREKDDGNDVRNLGKPVELAGKYFKQGADEVAFLNI 346 Query: 52 TGAKD---PAKRQIPLIKTLVAGVNVPVQVGGGVRS-----------EEDVAALLEAGVA 97 TG +D + +++ V VP+ VGGG+R E AA +AG Sbjct: 347 TGYRDLPLTDAPMLEVLRRSSETVFVPLTVGGGIRDFTDSNGVSYTALEVAAAYFKAGAD 406 Query: 98 RVVVGSTAVKSQDM-------------VKGWFERFGADALVLALDVRIDEQGN------- 137 +V +GS AV + ++ ER+G A+V+++D R + Sbjct: 407 KVSIGSDAVYVAEQYYANDKKKDGCTSIEQISERYGVQAMVVSIDPRRAYVADPSETKNR 466 Query: 138 ----------------KQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 Q V G +E + +L +G +L I DG G Sbjct: 467 CIKTSRPGPNGEEYVWFQCTVKGGREGRDIGAYELAIAMEDLGCGEILLNCIDEDGQGNG 526 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALLEGKFTVKEAIA 240 + L + A + +S G G+ + + G+ + E Sbjct: 527 FDHELVG-LVADAVTIPVIASSGAGEPKHFTDVFNATKCSAALAAGIFHRGEVDISEVKD 585 Query: 241 CWQ 243 + Sbjct: 586 HMK 588 >UniRef50_Q1IKB1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=2 Tax=Acidobacteria RepID=Q1IKB1_ACIBL Length = 228 Score = 155 bits (392), Expect = 1e-36, Method: Composition-based stats. Identities = 74/240 (30%), Positives = 116/240 (48%), Gaps = 19/240 (7%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 M+IP++DL+ G +V+L QG K+ D + + G ++ L+DL AK Sbjct: 1 MLIPSIDLMGGKIVQLVQG--EKKAFETTDFDAWCERF--AGFPMVQLIDLDAAKRQGD- 55 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVK----SQDMVKGWF 116 LI +V + +P QVGGGVR + LL G RV+VGS+ ++ D +G Sbjct: 56 NRELIANIV--LRLPCQVGGGVRDADVAERLLAIGAKRVIVGSSYIRDGRVDVDFARGLA 113 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 ER G D ++ A+D R VAV GWQE+ ++ +++ P + L T + + Sbjct: 114 ERCGTDRVIAAIDSR-----EGFVAVRGWQESVPITAGEMIAALTPY-VGGFLYTHVDTE 167 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G L G + + + ++GGI +++ L G GV V VG A+ GK VK Sbjct: 168 GLLVGFPTDIARRLRT-LTEKQLIAAGGIRSQEEIDELDGIGVDAV-VGMAIYTGKLVVK 225 >UniRef50_UPI00016C36C9 phosphoribosylformimino-5-aminoimidazole carboxamide isomerase family protein n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C36C9 Length = 235 Score = 154 bits (389), Expect = 3e-36, Method: Composition-based stats. Identities = 55/235 (23%), Positives = 89/235 (37%), Gaps = 13/235 (5%) Query: 9 IDGTVVRLHQGDYGKQRDY------GNDPLPRLQDY-AAQGAEVLHLVDLTGAKDPAKRQ 61 ++G VVR GD R P Q + GA L++ DL A + R Sbjct: 1 MNGVVVRAVGGDRKNYRPVRSPLTPSTVPTDIAQALLRSVGAGELYVADLD-AITGSARV 59 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 P ++ L+ VPV + G DV R VVG + +++ Sbjct: 60 TPSVEALMEACAVPVWLDAG-TGRRDVLDWPPHQNLRPVVGFETCRVPEVLAEALLEPRQ 118 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +LD+R + W L + +G++ ++ D++R GT G Sbjct: 119 RPVAFSLDLRNGQLLGNW---RAWGLAGDRDALALTRRVVDMGVRTLIVLDLARVGTGTG 175 Query: 182 SNV-SLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 + L + A +P + + GG+ DV L G GV+V AL EG + Sbjct: 176 AGTDELVRVIRAEFPDLDLIAGGGVRTWSDVERLGKAGATGVLVASALHEGTLVL 230 >UniRef50_Q5KNA0 Imidazoleglycerol phosphate synthase, putative n=3 Tax=Basidiomycota RepID=Q5KNA0_CRYNE Length = 619 Score = 152 bits (384), Expect = 1e-35, Method: Composition-based stats. Identities = 56/318 (17%), Positives = 110/318 (34%), Gaps = 82/318 (25%) Query: 2 IIPALDLID---GTVVRLHQGDYGKQRDYGND--------PLPRLQDYAAQGAEVLHLVD 50 I+ LD+ G +V + +GD R+ +D P+ Q Y GA+ + ++ Sbjct: 286 IVACLDVRSNDAGDLV-VTKGDQYDVREKSSDKAVRNLGKPVELAQRYYLSGADEVAFLN 344 Query: 51 LTGAKDPA---KRQIPLIKTLVAGVNVPVQVGGGVRS-----------EEDVAALLEAGV 96 +T + A + + +++ V VP+ +GGG++ E A +G Sbjct: 345 ITSFRSSALLDQPMLDVVRAAAETVFVPLTIGGGIKDTTDPDGTFHPALEVAGAYFRSGA 404 Query: 97 ARVVVGSTAVKSQDM-----------------VKGWFERFGADALVLALDVRIDEQG--- 136 +V +GS AV + + ++ + +G A+V+++D + Sbjct: 405 DKVSIGSEAVIAVEEMLEREARGEPALTGKTGIETISKGYGRQAVVVSIDPKRVYVDTSA 464 Query: 137 ----------------------------------NKQVAVSGWQENSGVSLEQLVETYLP 162 Q +SG + + + QL + Sbjct: 465 PGWLESFPAKHRASLIIGDNATSRTAPQEKGKAWWYQCTISGGRAVRDIDVVQLAQGVER 524 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRG 221 +G +L + RDG+ G ++ L ++ + SS G G D R TG Sbjct: 525 LGAGEILLNSVDRDGSGQGFDLDLV-KLVKNAVGIPVVSSSGAGSPADFEEVFRETGTEA 583 Query: 222 VIVGRALLEGKFTVKEAI 239 + G+ + E Sbjct: 584 ALAAGIFHRGEVGIDEVK 601 >UniRef50_Q4JIN2 Orf17 n=1 Tax=uncultured bacterium BAC10-10 RepID=Q4JIN2_9BACT Length = 248 Score = 152 bits (384), Expect = 1e-35, Method: Composition-based stats. Identities = 57/242 (23%), Positives = 100/242 (41%), Gaps = 18/242 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY---------GNDPLPRLQDYAA-QGAEVLHLVDL 51 +I +DL G V G DP + Y +G L++ DL Sbjct: 3 VIGVIDLAAGRAVHARGGRRTDYAPVRLSGAAAAHVGDPCALARTYLETRGLTELYVADL 62 Query: 52 TGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM 111 A Q I L+ + P+ + GV S L G + VVVG + S D+ Sbjct: 63 D-AIGGGPSQDAAIGALIR-LGAPLWLDSGVHSVPRARHALGLGASFVVVGLETLPSYDV 120 Query: 112 VKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 + G++ + +LD+R + + +G S+EQ+ + G+ ++ Sbjct: 121 LSEICADVGSERVAFSLDLR-----DGLPITAHADVAAGRSVEQIAARAVEAGVGAIIVI 175 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 D++R G G +++L + + P V + GG+ +D+A+L G GV+V AL +G Sbjct: 176 DVARVGMGEGVDLALISSLRSVAPAV-LLAGGGVRGSEDLASLAHAGCDGVLVATALHDG 234 Query: 232 KF 233 + Sbjct: 235 RI 236 >UniRef50_A6C0W3 HisA/HisF family protein, putative n=1 Tax=Planctomyces maris DSM 8797 RepID=A6C0W3_9PLAN Length = 247 Score = 151 bits (383), Expect = 1e-35, Method: Composition-based stats. Identities = 52/246 (21%), Positives = 95/246 (38%), Gaps = 24/246 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQ-GAEVLHLVDLTGA 54 IIP LD+++ T+VR G + + PL Q + G ++ DL Sbjct: 3 IIPVLDILNQTIVRGIAGQRETYQPIQSGLTHSSQPLDIAQALQDEFGFSEFYVADLDAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + + + L+ + + G+ D L + +V G ++S +K Sbjct: 63 LQQRL-NLQMYQCLLDAGFTFL-LDCGLHFAGDSQPLSKMKGITIVAGLETLESPQELKQ 120 Query: 115 WFERFGADALVLALD------VRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHV 168 + +GA + V +LD VR N A+ ++ E L G+ + Sbjct: 121 LVQNWGAASTVFSLDLKQGKPVRNSSSDNPYAAID--------DPLEIAELSLQQGVNQM 172 Query: 169 LCTDISRDGTLAGSNVSLY-EEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 + D++ GT G+ + + +P + + GGI IDD+ G V+V A Sbjct: 173 ILLDLANVGTGQGTGTEALCRTLRSHHPDLRLITGGGIHSIDDLQTQAEQGADAVLVASA 232 Query: 228 LLEGKF 233 L +G+ Sbjct: 233 LHDGRL 238 >UniRef50_Q6SHC0 Imidazoleglycerol phosphate synthase, cyclase subunit n=1 Tax=uncultured marine bacterium 440 RepID=Q6SHC0_9BACT Length = 262 Score = 151 bits (382), Expect = 2e-35, Method: Composition-based stats. Identities = 44/255 (17%), Positives = 102/255 (40%), Gaps = 17/255 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTG-------- 53 IIP L + +G +VR ++ K + G + + + + + L +D+T Sbjct: 7 IIPVLFIKNGLIVR--SQNFYKHQFIG-NVIEQAKRLNDYDVDELVYIDITRNDNYDLGR 63 Query: 54 ---AKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQD 110 + + +IK + +P+ GGG+RS +D + AG ++ + S K + Sbjct: 64 DDLLVKSKRDIMSIIKDISKVCFMPLTFGGGIRSVDDAVNRIRAGADKITINSLLYKDLN 123 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 +VK G+ A+V ++D +I + + Q+N+ + L ++ +G+ Sbjct: 124 IVKKIISEIGSQAVVASIDYKII-NEKLIIFNNFGQDNTNIELIDFIKKIENLGVGEFFI 182 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRGVIVGRALL 229 ++ DG G +++ +++ + + G G ++ G+ V G Sbjct: 183 QNVELDGMQKGFDLNNIKKIV-NSVNLPVIACSGAGSLEHFLEAVKIKGLSAVAAGNYFN 241 Query: 230 EGKFTVKEAIACWQN 244 + + ++ Sbjct: 242 YKERSYPIIKKELKD 256 >UniRef50_C9RDL3 HisA/hisF family protein n=3 Tax=Methanococcales RepID=C9RDL3_METVM Length = 229 Score = 151 bits (382), Expect = 2e-35, Method: Composition-based stats. Identities = 51/251 (20%), Positives = 96/251 (38%), Gaps = 35/251 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +D+ V G K + +DP+ + Y +G+E++++ DL A Sbjct: 3 IIPVIDIKGNIAVHGKSGMRSKYQPLKSVICETSDPICLAKSYKEKGSEMVYIADLD-AI 61 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEA--GVARVVVGSTAVKSQDMVK 113 LIK + + V G+++ ED+ + E + ++ + + ++++ Sbjct: 62 CGEGDNFNLIKNID---FINKIVDAGIKTREDLERVREYLNKNDKAIIATETLIDKELIS 118 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 ++++LD + + N V L + DI Sbjct: 119 E-------KNIIVSLDFKDGKLLNYTVEEVLGLVRKDTPL---------------IILDI 156 Query: 174 SRDGTLAGSNVSLYEEVCARYPQV-AFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 S GT G N+ L + GGI DI D+ G+ GV+VG A+ G Sbjct: 157 SSVGTGRGINMKLINMILKLNKGKNPIYVGGGIRDITDIEKCYNLGIDGVLVGTAIHRGV 216 Query: 233 FTVKEAIACWQ 243 ++E I ++ Sbjct: 217 IDLEEVIKKFE 227 >UniRef50_Q7MPP3 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Vibrio vulnificus YJ016 RepID=HIS62_VIBVY Length = 272 Score = 151 bits (381), Expect = 2e-35, Method: Composition-based stats. Identities = 48/245 (19%), Positives = 97/245 (39%), Gaps = 6/245 (2%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP + VV+ + G + + + + + + D+ +K+ + Sbjct: 9 LIPCIVTKGELVVQ--SFAFKNYLPIG-NVKTAIDFFVNWDVDEIIVNDIDASKEFREPN 65 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + L+ VP+ VGGG+++ E + LL+AG +V + + A+ D +K FG+ Sbjct: 66 VDLVSWAAKECFVPLTVGGGIKTLEHIRNLLKAGADKVTINTKAIDDPDFIKNAASVFGS 125 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + +++D ++ V + V G +L + RDG+ G Sbjct: 126 QCITVSVDAIKQGNV-YKLYDYRDGRVLDVDVVDWVRKVESYGAGEILLNSVDRDGSREG 184 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGVIVGRALLEGKFTVKEAIA 240 +V L + V + + + GGIG D +A G + + + + A A Sbjct: 185 YDVELLKTV-SGIVSIPVIALGGIGRFDQLAEGAIEGGCQALSAANIFQHMEHSTIAAKA 243 Query: 241 CWQNA 245 +NA Sbjct: 244 QMRNA 248 >UniRef50_A8M908 Histidine biosynthesis protein n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8M908_CALMQ Length = 228 Score = 150 bits (380), Expect = 3e-35, Method: Composition-based stats. Identities = 69/234 (29%), Positives = 114/234 (48%), Gaps = 22/234 (9%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRD--YGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 ++IP++DL +G VV+ +G G + N+ L ++DY +H+VDL GA+ Sbjct: 4 LVIPSIDLSNGLVVKRVRGVKGSELVKLNLNEALSLVKDY-----PFIHVVDLNGAELGK 58 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 + I + A VN +VGGGVR ED LL+ +RVV+G+ AV++ ++ R Sbjct: 59 PINVDSIAKIGATVNGRCEVGGGVRVIEDAELLLKY-CSRVVLGTVAVENPALLLNMINR 117 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVG-LKHVLCTDISRDG 177 G D + ++LD + + GW GV ++++ + + V+ T++S +G Sbjct: 118 LGVDKVAVSLDT-----DGEWLMTRGW----GVRARRIMDALSNLPRVSAVIYTNVSVEG 168 Query: 178 TLAGS--NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 T G N L + + +GG+ DV L G G GVI+G AL Sbjct: 169 TGMGPRVNGELVKRLRD--IGKEVYYAGGVSSCSDVEYLWGLGFDGVIIGYALY 220 >UniRef50_A2BSD9 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. AS9601 RepID=A2BSD9_PROMS Length = 254 Score = 150 bits (380), Expect = 4e-35, Method: Composition-based stats. Identities = 38/218 (17%), Positives = 93/218 (42%), Gaps = 4/218 (1%) Query: 14 VRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDL-TGAKDPAKRQIPLIKTLVAGV 72 R+ + K Y DPL ++ + ++ + + ++ K ++ + Sbjct: 16 KRMIKRSKFKNYKYLGDPLNIIRIFNSKRVDEISIISCENYEKKDINIDFEFLEKISGEA 75 Query: 73 NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRI 132 P+ GGVRS ED L G ++ + + + +++K E++G+ ++V+ +D + Sbjct: 76 FCPLTYSGGVRSLEDADKLFSIGFEKIGIRNLLHTNPEVIKQIAEKYGSQSVVIFIDYKE 135 Query: 133 DEQGNKQVAV--SGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEV 190 ++ + + +++ S+ + ++ G V+ I R+G G ++ + +E+ Sbjct: 136 LNNNEIEIYTSYNSFFKSTKSSILEFIKNAESYGAGEVVLQSILREGQSKGLDLDIIKEI 195 Query: 191 CARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRAL 228 + + SS G+ D+ D G GV+ + Sbjct: 196 TNK-TILPIISSCGMRDLSDARKAFSLGADGVMASKFF 232 Score = 42.1 bits (98), Expect = 0.018, Method: Composition-based stats. Identities = 9/94 (9%), Positives = 30/94 (31%), Gaps = 2/94 (2%) Query: 152 SLEQLVETYLPVGLKHV-LCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDD 210 ++ + + + + + + + + E++ SGG+ ++D Sbjct: 32 DPLNIIRIFNSKRVDEISIISCENYEKKDINIDFEFLEKISGEA-FCPLTYSGGVRSLED 90 Query: 211 VAALRGTGVRGVIVGRALLEGKFTVKEAIACWQN 244 L G + + L +K+ + + Sbjct: 91 ADKLFSIGFEKIGIRNLLHTNPEVIKQIAEKYGS 124 >UniRef50_A5UNR3 ProFAR isomerase-related protein n=3 Tax=Methanobrevibacter smithii RepID=A5UNR3_METS3 Length = 229 Score = 149 bits (378), Expect = 6e-35, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 102/239 (42%), Gaps = 22/239 (9%) Query: 3 IPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAKD 56 +P LDL D V G +P+ + GA+ L++ DL + Sbjct: 5 VPVLDLKDNIAVSGKSGLRDTYTPLQTVFAPSANPVDIANGLSINGADELYIADLD-LIE 63 Query: 57 PAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWF 116 I +K + +PV + GV+ E L+ +++V + +KS +K F Sbjct: 64 GNGHNIHDVKMV--NSILPVMLDAGVKDFESFTFFLDY-AYKIIVPTETIKSIGEIKKIF 120 Query: 117 ERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRD 176 E++ + +V+++DV+ +E + +N +SL + E + ++ DI+ Sbjct: 121 EKYPKERIVVSVDVKDNEL---------YSKNLNISLAEFKEILEELDPDEIILLDITGV 171 Query: 177 GTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTV 235 GT G N L ++ + +GG+ + V+ L G++ V+VG AL G+ + Sbjct: 172 GTQKGYNQELLDDFKDLKDK--LIIAGGLNNKS-VSELEDMGIKKVLVGTALHSGEMKL 227 >UniRef50_Q58114 Uncharacterized protein MJ0703 n=8 Tax=Methanococcales RepID=Y703_METJA Length = 226 Score = 149 bits (377), Expect = 7e-35, Method: Composition-based stats. Identities = 52/251 (20%), Positives = 101/251 (40%), Gaps = 35/251 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL D V G+ + + ++P+ + Y +GA+ +++ DL Sbjct: 3 IIPVIDLKDKIAVHGKSGNRDEYKPLESVICKSSNPIEVAKAYKERGAKTIYIADLNFIM 62 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGV--ARVVVGSTAVKSQDMVK 113 +IK + + V GV+S ED+ + + R +V + +K +++K Sbjct: 63 GNGD-NFDIIKEID---FINKIVDIGVKSREDLETIKKVLNKDDRAIVATETLKDIELLK 118 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 +V++LD + N SL++++ ++ DI Sbjct: 119 E-------KDIVVSLDFKNGNLLNY-------------SLDEILSCVRDDTP--LIILDI 156 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 S GT G N L + V + GGI ++D+ GV V++ A+ +G Sbjct: 157 SSVGTQRGVNAELIKYVLDK-TNNPVYVGGGIKGMEDLELCYNLGVDAVLIATAIHKGVL 215 Query: 234 TVKEAIACWQN 244 ++E I + + Sbjct: 216 DLEEIINKFGD 226 >UniRef50_D1SND3 HisA/hisF family protein n=1 Tax=Methanocaldococcus sp. FS406-22 RepID=D1SND3_9EURY Length = 237 Score = 148 bits (374), Expect = 2e-34, Method: Composition-based stats. Identities = 54/251 (21%), Positives = 103/251 (41%), Gaps = 29/251 (11%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL++ V G+ + + +P+ Y +GAE +++ DL Sbjct: 3 IIPVIDLMNKIAVHGKSGNRDEYKPLKSVICNSPNPIDVAMAYKERGAETIYIADLNFIM 62 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAAL--LEAGVARVVVGSTAVKSQDMVK 113 +IK + V V GV+ ED+ + + + +V + +K +++K Sbjct: 63 GNGD-NFEVIKEID---FVNKIVDIGVKRREDLENIKKILNKDDKAIVATETLKDIELLK 118 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 +V++LD + + + +++ S + V P+ DI Sbjct: 119 E-------KDIVVSLDFK----NGELLLDKNFKDYSLDGILSYVREDTPL-----TILDI 162 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 S GT G NV L + V + GGI +DD+ GV GV++ A+ +G Sbjct: 163 SSVGTQRGINVELIKYVLDK-TNNPVYVGGGIKGMDDLELCYNLGVDGVLIATAIHKGIL 221 Query: 234 TVKEAIACWQN 244 ++E I+ + + Sbjct: 222 DLEEIISKFSD 232 >UniRef50_O26765 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase related protein n=1 Tax=Methanothermobacter thermautotrophicus str. Delta H RepID=O26765_METTH Length = 227 Score = 147 bits (372), Expect = 3e-34, Method: Composition-based stats. Identities = 60/236 (25%), Positives = 102/236 (43%), Gaps = 23/236 (9%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGAEVLHLVDLTGAK 55 IIP +DL+DG V G+ K R DP+ A GA +++ DL A Sbjct: 4 IIPVIDLMDGIAVSGKSGEREKYRPLESVYSPSPDPVNIALSLRAAGARSIYIADLD-AI 62 Query: 56 DPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 + + ++ + +PV + GVR E +LE +RVVV + ++S + ++ Sbjct: 63 EGTGSNLEAVRRVNHV--LPVILDAGVRDLETFHFMLEF-ASRVVVATETLESTEELEEI 119 Query: 116 FERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISR 175 + + V+++DV+ + N + LE+L + + + ++ DI Sbjct: 120 LRNYPPERTVVSVDVKD---------MRLHSRNLEIGLEELRDLLMGYEVD-IILLDIGS 169 Query: 176 DGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 GT +G N L E GG+ +++ L GVR +VGRAL EG Sbjct: 170 VGTSSGFNRELLELFRPLI--ERVIPGGGV-LPEEIPELEAMGVRAALVGRALHEG 222 >UniRef50_Q4J8J0 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=1 Tax=Sulfolobus acidocaldarius RepID=Q4J8J0_SULAC Length = 226 Score = 147 bits (371), Expect = 4e-34, Method: Composition-based stats. Identities = 60/232 (25%), Positives = 105/232 (45%), Gaps = 14/232 (6%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 ++P++D+ + V+ +G G G DPL ++ ++G + +H+VDL A + Sbjct: 3 VMPSIDISNKVAVKRIRGKGGSGIILG-DPLKIAKEIISEGYDAIHIVDLDAA-EGLGDN 60 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +IK + QVGGGVR E +LE + +VV + + ++ G Sbjct: 61 KDIIKQICTLGFSWTQVGGGVRKLEIAKDILEY-CSSIVVSTLPITNRQEYDKIISGVGV 119 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 D + L++D N V + GW+E S V L + V+ T I +GT G Sbjct: 120 DKVFLSIDY----DDNGYVLIKGWKEKSVK-----VSDLLDLESGGVIFTYIPNEGTKGG 170 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + ++ E V + + + +GGIG +DD+ L+ G I+G + G Sbjct: 171 IDNNVVEYV--KSVKKIKEYAGGIGSLDDLLKLKSFGFDYSIIGMSFYNGTL 220 >UniRef50_C6QGP7 Histidine biosynthesis protein n=3 Tax=Rhizobiales RepID=C6QGP7_9RHIZ Length = 235 Score = 146 bits (370), Expect = 5e-34, Method: Composition-based stats. Identities = 55/249 (22%), Positives = 91/249 (36%), Gaps = 26/249 (10%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAA-QGAEVLHLVDLTGA 54 IIP +D+ G VVR QG ++P + + ++ DL G Sbjct: 3 IIPVIDVSRGKVVRAIQGKRAAYLPIETPLAATSEPGDVARGLRSLYPFRRAYVADLDGI 62 Query: 55 KDPAKRQIPLIKTLVAG-VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 + R L+ L N + + G S A+L A VA +VVGS +++S Sbjct: 63 -EGRGRNTHLVPELSQALPNTELWIDAGTGSRSAARAVLAAPVATLVVGSESLESVRAWH 121 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 VL+LD R DE + + + V+ + Sbjct: 122 EISAEAPG-RTVLSLDFRGDEFMGP----------------EALLADAALWPTRVIVMTL 164 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 R + G N++L E + AR ++GGI ++D+A + G G +V L K Sbjct: 165 DRIASEGGPNIALLETIAARAGGRRVYAAGGIRSLEDLARIGKAGAAGALVASILHAQKI 224 Query: 234 TVKEAIACW 242 + + Sbjct: 225 SAGDLKEIA 233 >UniRef50_B8LDL7 N-acetyl-glutamate-gamma-semialdehyde dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335 RepID=B8LDL7_THAPS Length = 570 Score = 146 bits (369), Expect = 6e-34, Method: Composition-based stats. Identities = 46/293 (15%), Positives = 101/293 (34%), Gaps = 59/293 (20%) Query: 7 DLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDP---AKRQIP 63 D+ + Q G R+ G P+ Y +GA+ + +++T + + Sbjct: 271 DVRENE-KEGVQEGRGGVRNLGK-PVSLASRYYKEGADEIAFLNITSFRSGVIEDMPMLQ 328 Query: 64 LIKTLVAGVNVPVQVGGGVRSEED------------VAALLEAGVARVVVGSTAVKSQDM 111 +++ + VP+ VGGG+RS ED + AG +V +GS +V + + Sbjct: 329 VLEEASKEIFVPLTVGGGIRSYEDPGTGKVYSALEVASRYFRAGADKVSIGSDSVHAAEE 388 Query: 112 -------------VKGWFERFGADALVLALDVRI-------------------------- 132 ++ +G A+V+++D + Sbjct: 389 YIASGNTKTGQTSIETISHVYGVQAVVISIDPKRVYVTSPDAADSKHTVVTLDDSQKGPN 448 Query: 133 -DEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVC 191 ++ Q V G +E + + + +G ++ I DG G + +L + V Sbjct: 449 GEQYCWYQCTVKGGREARDICAVSVAKAAEALGAGEIMLNCIDMDGQCNGFDHALMKAV- 507 Query: 192 ARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVKEAIACWQ 243 + + +S G G + + T V+ + + + + + Sbjct: 508 SDAVTIPVIASSGAGKESHFSDVFSETSVQAALAAGMFHRKEVEIADVKKHME 560 Score = 44.0 bits (103), Expect = 0.004, Method: Composition-based stats. Identities = 28/177 (15%), Positives = 52/177 (29%), Gaps = 36/177 (20%) Query: 81 GVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQV 140 GV + L++ G+ + V G +V+ALDVR ++ G+ V Sbjct: 209 GVTGLNFIRGFLDSVAD----GTLSNTQPLEVDGSKHTELVKRVVVALDVRSNDHGDLVV 264 Query: 141 AV-----------------SGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAGSN 183 G N G L Y G + +I+ + + Sbjct: 265 TKGDQYDVRENEKEGVQEGRGGVRNLG-KPVSLASRYYKEGADEIAFLNITSFRSGVIED 323 Query: 184 VSLYEEVCARYPQV--AFQSSGGIGDIDD------------VAALRGTGVRGVIVGR 226 + + + + ++ GGI +D + G V +G Sbjct: 324 MPMLQVLEEASKEIFVPLTVGGGIRSYEDPGTGKVYSALEVASRYFRAGADKVSIGS 380 >UniRef50_C0N3H2 Histidine biosynthesis protein n=1 Tax=Methylophaga thiooxidans DMS010 RepID=C0N3H2_9GAMM Length = 237 Score = 144 bits (365), Expect = 2e-33, Method: Composition-based stats. Identities = 44/252 (17%), Positives = 90/252 (35%), Gaps = 32/252 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQ------RDYGNDPLPRLQ-DYAAQGAEVLHLVDLTGA 54 IIP +D+ G VV G+ D + E ++ DL Sbjct: 3 IIPVIDIRGGIVVHARGGNRDAYSALNSVLTRSTDVFQVVNDILNWYPFEQFYIADLDAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + R + + + G+ S++D+ + ++V+GS +KS +++ Sbjct: 63 EAAKHRPEFYAELVHCFTGTQFWLDAGITSQKDLRLYSKLHNLKIVIGSETLKSLSLLEI 122 Query: 115 WFERFGADALVLALDVRIDE---QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 R +++L+LD R + N W E + + Sbjct: 123 EGAR---QSMILSLDRRGKQLLGAHNLLHRTELWTEQT-------------------IVM 160 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 D+ G G ++ + + A+ P + + ++GG+ + D+ L+ G ++ AL G Sbjct: 161 DLDVIGANQGPSLEWLQALIAQRPDIEWYAAGGVRNKADLEQLQKIRAAGTLIASALHTG 220 Query: 232 KFTVKEAIACWQ 243 + E Q Sbjct: 221 QIDKAELQKIEQ 232 >UniRef50_C0WXE8 Imidazole glycerol phosphate synthase n=2 Tax=Lactobacillus fermentum RepID=C0WXE8_LACFE Length = 188 Score = 144 bits (364), Expect = 2e-33, Method: Composition-based stats. Identities = 39/183 (21%), Positives = 83/183 (45%), Gaps = 4/183 (2%) Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFG 120 + +++ + V +P+ V VR+ +V LL AG +V + + ++ + D + + FG Sbjct: 1 MLDMVEAISQQVFMPMTVVCNVRTVVEVRNLLLAGADKVGISTRSIMAPDFIPKVAQVFG 60 Query: 121 ADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLA 180 ++V LD +D + N+++ + N+ + + + +G+ +L + RDGT Sbjct: 61 NQSIVAILDYHVDPRTNRKIVCTPG--NTELDAYEWTLRVVELGVGELLVNSMDRDGTEN 118 Query: 181 GSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALR-GTGVRGVIVGRALLEGKFTVKEAI 239 G + + Y ++ + +SGG G D + +GV G + A + T+ E Sbjct: 119 GFDTAFYRDLTTTLT-IPVVASGGAGSTVDFEEVFVNSGVTGAMAASAFHLDQMTISEVK 177 Query: 240 ACW 242 Sbjct: 178 ETL 180 >UniRef50_Q062W6 Putative cyclase hisF n=1 Tax=Synechococcus sp. BL107 RepID=Q062W6_9SYNE Length = 255 Score = 142 bits (360), Expect = 6e-33, Method: Composition-based stats. Identities = 33/184 (17%), Positives = 83/184 (45%), Gaps = 3/184 (1%) Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVG 102 + L ++D++ K + ++ + +P+ +GG + S +D L+ G ++++ Sbjct: 47 IDELVILDVSREKPDRQEFCEVVNEVCQNCFMPLALGGHINSLDDAKMLIYNGADKLIIN 106 Query: 103 STAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLP 162 + ++ ++V+ +G+ ++ ++D +I E+G+ V + ++ L + +E Sbjct: 107 TALHENPNLVRELIAIYGSQCIIGSVDYKI-EEGSFIVYTNQGKKRLDRPLNEHIERLGE 165 Query: 163 VGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRG 221 +G+ + I RDGT G + +++ + +GG G+ + L GV Sbjct: 166 MGVGELYLNSIDRDGTGQGYVSEVLKQL-DSASHLPIIQAGGAGNKHHLQESLECRGVDA 224 Query: 222 VIVG 225 V Sbjct: 225 VATA 228 Score = 40.5 bits (94), Expect = 0.055, Method: Composition-based stats. Identities = 20/83 (24%), Positives = 34/83 (40%), Gaps = 7/83 (8%) Query: 165 LKHVLCTDISRDGTLAGSNVSLYEEVCARYPQ---VAFQSSGGIGDIDDVAALRGTGVRG 221 + ++ D+SR+ + + EV Q + G I +DD L G Sbjct: 47 IDELVILDVSRE----KPDRQEFCEVVNEVCQNCFMPLALGGHINSLDDAKMLIYNGADK 102 Query: 222 VIVGRALLEGKFTVKEAIACWQN 244 +I+ AL E V+E IA + + Sbjct: 103 LIINTALHENPNLVRELIAIYGS 125 >UniRef50_Q1H0R8 Histidine biosynthesis n=1 Tax=Methylobacillus flagellatus KT RepID=Q1H0R8_METFK Length = 234 Score = 141 bits (355), Expect = 3e-32, Method: Composition-based stats. Identities = 54/243 (22%), Positives = 96/243 (39%), Gaps = 33/243 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGA-------EVLHLVDLTGA 54 +IP +DL++G VV QG+ + ++ + GA L++ DL A Sbjct: 3 VIPVIDLMNGAVVHARQGNRAHYQPIVSNLCNGSEAQEIVGALLGLYPFPALYIADLD-A 61 Query: 55 KDPAKRQIPLIKTL-VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVK---SQD 110 LI TL + + V G+ S V + R V+G+ ++ + Sbjct: 62 IQCRNDHRTLIHTLLSKHPTLEIWVDAGINSVAKVQRW-QHPRLRPVLGTESIPSIATWH 120 Query: 111 MVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLC 170 ++ G E +L+LD +G+Q +L++ +HV+ Sbjct: 121 LLAGACEG----RHILSLDF----------TTAGYQ-----GPSELLQE-ARHWPQHVII 160 Query: 171 TDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 + G+ AG ++ A P+ ++GGI D D+ LR G++G +V AL Sbjct: 161 MSLPHVGSHAGPDMDKLTHFRALSPKHHLYAAGGIRDASDLQLLRKRGIKGALVASALHN 220 Query: 231 GKF 233 G Sbjct: 221 GNL 223 >UniRef50_B2JX56 Histidine biosynthesis protein n=6 Tax=Burkholderia RepID=B2JX56_BURP8 Length = 264 Score = 140 bits (353), Expect = 5e-32, Method: Composition-based stats. Identities = 54/260 (20%), Positives = 91/260 (35%), Gaps = 19/260 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGND------PLPRLQDYAAQGAE-VLHLVDLTGA 54 +IP LDL+DG VR +GD R + PL + A A L++ DL GA Sbjct: 3 VIPVLDLLDGHAVRAIRGDRANYRPIQSSLCTTSQPLDVARALIATTAACALYVADL-GA 61 Query: 55 KDPAKRQIPLIKTLVAGVN----VPVQVGGGVRSEEDVAALLEAGVARVVV--GSTAVKS 108 + L + + + + G + A LE A + Sbjct: 62 IMSGNADPSTLAALATSSDRSRPLEIWLDAGFADFPSMLAHLERIACAPNAAPKQAAPEQ 121 Query: 109 QDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSG--VSLEQLVETY--LPVG 164 FG+++L +LD + + G ++ +L + Sbjct: 122 AAPGARIVPVFGSESL-RSLDALREADAAGYAPILSLDHRHGQLIAAPELADALRSPASW 180 Query: 165 LKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIV 224 V+ + + G+ AG N + V A+ Q +GGI D+ A +G +V Sbjct: 181 PSRVIVMTLDQVGSDAGPNCDTFHHVHAQAGQRMTIGAGGIRHRGDLDAAARSGAHAWLV 240 Query: 225 GRALLEGKFTVKEAIACWQN 244 AL +GK A ++ Sbjct: 241 ASALHDGKLEPAAATRATRS 260 >UniRef50_Q7U923 Putative imidazole glycerol phosphate synthase subunit hisF2 n=1 Tax=Synechococcus sp. WH 8102 RepID=HIS62_SYNPX Length = 269 Score = 139 bits (351), Expect = 8e-32, Method: Composition-based stats. Identities = 39/189 (20%), Positives = 81/189 (42%), Gaps = 3/189 (1%) Query: 38 YAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVA 97 Y+A + L ++D++ + L+ L + VP+ GGG+RS ED L E G Sbjct: 42 YSATFIDELIILDISRKSRDINKFATLLYNLSENIFVPITAGGGIRSFEDAKVLFENGAD 101 Query: 98 RVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLV 157 +V + ++ ++ + + +G +LV ++D + + G+ + + ++++L+ Sbjct: 102 KVCLNTSLIQCPHVSEKISSVYGQQSLVASIDFK-HDHGDFKFFIDNGLIEVQYNIQELI 160 Query: 158 ETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRG 216 P+ +L + RDGT G +++L + + GG G D + L Sbjct: 161 SFLDPLPFCEILLQSVDRDGTGTGFDLTLANTFRDQLSK-PIILLGGAGHSDHLVEGLLH 219 Query: 217 TGVRGVIVG 225 V Sbjct: 220 QSTDAVATA 228 Score = 42.8 bits (100), Expect = 0.009, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 26/67 (38%), Gaps = 7/67 (10%) Query: 165 LKHVLCTDISRDGTLAGSNVSLYEEVCARYPQ---VAFQSSGGIGDIDDVAALRGTGVRG 221 + ++ DISR +++ + + + V + GGI +D L G Sbjct: 47 IDELIILDISRKSR----DINKFATLLYNLSENIFVPITAGGGIRSFEDAKVLFENGADK 102 Query: 222 VIVGRAL 228 V + +L Sbjct: 103 VCLNTSL 109 >UniRef50_A8PRW0 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PRW0_MALGO Length = 576 Score = 139 bits (351), Expect = 8e-32, Method: Composition-based stats. Identities = 53/325 (16%), Positives = 104/325 (32%), Gaps = 97/325 (29%) Query: 16 LHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKD---PAKRQIPLIKTLVAGV 72 + G + R+ G P+ Q Y +GA+ + +++T ++ + + L+ A + Sbjct: 247 IRSGGKAQVRNMGK-PVELAQRYYEEGADEIAFLNITSFRNWALGDQPMLSLLNVAAATI 305 Query: 73 NVPVQVGGGVRS-----------EEDVAALLEAGVARVVVGSTAVKSQDM---------- 111 VP+ VGGG+R E A AG +V +GS AV + + Sbjct: 306 FVPLTVGGGIRDFTDPDGTFHPALEVAHAYFRAGADKVSIGSEAVYAVEQLLQRATELGD 365 Query: 112 ------------------VKGWFERFGADALVLALDVRIDEQGN---------------- 137 ++ ++G A+V+++D + + Sbjct: 366 CTGDPCAAPAMALRGDTGIEQIAHKYGVQAVVVSVDPKRVYLSDQEIDGLSDEHSSGDGP 425 Query: 138 ------------------------------KQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 V G +E+ + + QL +G Sbjct: 426 VDARTHPHASSIVCGQDERPETAGQSARWWYMCTVKGGRESRDIDVVQLARGVERLGAGE 485 Query: 168 VLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV-------AALRGTGVR 220 +L I RDG+ AG + L ++ + +S G G D A RG + Sbjct: 486 LLINSIDRDGSYAGFDEKLI-DLVRGCVNIPVIASSGAGCADHFCDVLASRPAARGAPIE 544 Query: 221 GVIVGRALLEGKFTVKEAIACWQNA 245 + + ++ + +A Sbjct: 545 AALAAGIFHRREVSIMDVKKRCADA 569 >UniRef50_Q603E0 Putative HisA/HisF family protein n=1 Tax=Methylococcus capsulatus RepID=Q603E0_METCA Length = 227 Score = 139 bits (351), Expect = 9e-32, Method: Composition-based stats. Identities = 53/243 (21%), Positives = 92/243 (37%), Gaps = 33/243 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN------DPLPRLQDYAA-QGAEVLHLVDLTGA 54 IIP LDL+ G VV +G R + DP ++ + + ++ DL Sbjct: 3 IIPVLDLMQGRVVHAVKGRRENYRPLSSPLCPDADPRAVVEAFRNLYRFDTFYIADLDAL 62 Query: 55 KDPAKRQIPLIKTLVAGV-NVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 + LI L ++ + G+ E A L+ V V+GS ++ + D ++ Sbjct: 63 MGLGCQN-ELIAALRTAFPDIVFWLDRGL--PEAGEAALDGVV--PVIGSESLPTVDRLQ 117 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 R +L+LD G + L Q + V+ + Sbjct: 118 RMTTR----DWILSLD-----------FFDGTLKGCSRLLAQ-----PQCWPERVIVMTL 157 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 +R G+ G ++ L + V P A ++GG+ D D+ L G+ V+V AL G Sbjct: 158 NRVGSFDGPDLDLLDRVRRLTPHRALIAAGGVRDAGDLEILERRGIHAVLVASALHSGSL 217 Query: 234 TVK 236 + Sbjct: 218 ELS 220 >UniRef50_C6XDW4 Histidine biosynthesis protein n=1 Tax=Methylovorus sp. SIP3-4 RepID=C6XDW4_METSD Length = 232 Score = 138 bits (349), Expect = 1e-31, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 91/245 (37%), Gaps = 28/245 (11%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAA-QGAEVLHLVDLTGA 54 IIP +DL++ VV +G+ R + PL + + L++ DL A Sbjct: 3 IIPVIDLLEHHVVHAKRGERQHYRPIESGLCDSSQPLAITRALLELYPFDTLYIADLN-A 61 Query: 55 KDPAKRQIPLIKTLVAG-VNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 + I + + + + G ++ D+ V V+GS ++ + Sbjct: 62 IQGKPAHVDEIALIRQHYPQLRIWLDAGFKNTRDLLPWSGLEVT-PVIGSESLPDIGAYQ 120 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 A VL+LD R D + + + + V+ + Sbjct: 121 ELISE--GVAHVLSLDFRGDRYQGPEALLDN----------------PRLWPQLVIGMTL 162 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 + G+ G + + +++ +GG+ DI+D+ LR G+ G +V AL G+ Sbjct: 163 ANVGSNQGPDHARLQQLVGMAQHGKLYGAGGVRDINDLQRLREQGIAGALVASALHSGQI 222 Query: 234 TVKEA 238 + ++ Sbjct: 223 SSQDI 227 >UniRef50_Q7WYR2 Imidazole glycerol phosphate synthase, subunit HisF2 n=3 Tax=Rhizobium RepID=Q7WYR2_RHIL3 Length = 251 Score = 136 bits (344), Expect = 4e-31, Method: Composition-based stats. Identities = 41/212 (19%), Positives = 86/212 (40%), Gaps = 8/212 (3%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 +IP L + RL + +R Y DP ++ + + + + ++D+ + Sbjct: 5 LIPVLLVDQKR--RLVKTIEFGERTYVGDPFNVVRLFNEKEVDEICILDIDATRTGRGPD 62 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 + ++ L +P+ GGG+ + L +GV + V+G A ++ +V G+ Sbjct: 63 LGFVRELATECFMPLAYGGGITELKQCEELNRSGVEKFVLGQGA-RNSQLVGAIAADMGS 121 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 ALV +DV A SG ++ + G+ ++ + DGT G Sbjct: 122 QALVACVDVDGRGAAASCYASSGARQ----EPIEFCLRLQDAGVGEIILQSKTLDGTRNG 177 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA 213 ++ L + + + + + GG GD+ + Sbjct: 178 YDLELIQSITRKLS-IPVVALGGAGDVAHLME 208 >UniRef50_B8HVG9 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamideisomerase n=1 Tax=Cyanothece sp. PCC 7425 RepID=B8HVG9_CYAP4 Length = 226 Score = 136 bits (344), Expect = 5e-31, Method: Composition-based stats. Identities = 66/229 (28%), Positives = 99/229 (43%), Gaps = 17/229 (7%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 IIPAL +++G Q + DP+ + +A QGA LHL+D G A Sbjct: 3 IIPALKIMEGFCCHHRQ-----PYRFNCDPVAMAEQWANQGATRLHLIDCNGVTTGAMLN 57 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 +P I +V V VPVQV G + S + L GV RVVV + + ++V E F Sbjct: 58 LPTIAAIVQQVKVPVQVEGTIYSRAQIETLFAIGVDRVVVDGS-IGWSELVADLCEHFSG 116 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 +V E + +VA SG E +G+ L E VG ++ TDI+R G+ Sbjct: 117 KIMV------NLEAYDGRVACSG--ELTGLLATTLAERAEAVGAAGIIYTDIARQGSGI- 167 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLE 230 N+ + + A + + GG I ++ L IVG + Sbjct: 168 INLKALKHL-ADRVNLPIIAGGGASSIAELLRLFNPSTP-QIVGMMVYS 214 >UniRef50_A8TG14 Histidine biosynthesis protein n=1 Tax=Methanococcus voltae A3 RepID=A8TG14_METVO Length = 148 Score = 132 bits (334), Expect = 7e-30, Method: Composition-based stats. Identities = 44/134 (32%), Positives = 82/134 (61%), Gaps = 5/134 (3%) Query: 29 NDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDV 88 ++P + + GAE+LHLVDL GA D + +P++K ++ VPVQ+GGG+R+ EDV Sbjct: 4 DNPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQESKVPVQMGGGIRTIEDV 63 Query: 89 AALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQEN 148 L+ G+ RV++G+ AV++ D V+ ++ G++ +++ALD + + +V + GW+E Sbjct: 64 EELVNLGINRVIIGTVAVQNPDFVEKLAKKVGSEKIMVALDAK-----DGKVVIKGWKEK 118 Query: 149 SGVSLEQLVETYLP 162 + + Q+ + Sbjct: 119 TEYTPVQMGKYLRK 132 Score = 54.8 bits (131), Expect = 3e-06, Method: Composition-based stats. Identities = 16/75 (21%), Positives = 35/75 (46%), Gaps = 1/75 (1%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 + +++ + ++ G + + D+ N+ + +++ +V Q GGI I+DV Sbjct: 5 NPDEIAKMWVENGAEMLHLVDLDGAIDGERVNLPMVKKIIQE-SKVPVQMGGGIRTIEDV 63 Query: 212 AALRGTGVRGVIVGR 226 L G+ VI+G Sbjct: 64 EELVNLGINRVIIGT 78 >UniRef50_A8V5Z6 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8V5Z6_9AQUI Length = 119 Score = 132 bits (334), Expect = 7e-30, Method: Composition-based stats. Identities = 43/114 (37%), Positives = 75/114 (65%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKR 60 IIPA+D+ +G VRL++GD + YG++P+ + + +GA+ LH+VDL GA + + Sbjct: 6 FIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHIVDLDGAFEGIPK 65 Query: 61 QIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 +++ +V VNVP++ GGG+R+ E V ++E GV RVV+GS A + +++ + Sbjct: 66 NYKIVEQIVKSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDKELFEK 119 Score = 56.7 bits (136), Expect = 7e-07, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 45/113 (39%), Gaps = 5/113 (4%) Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + ++ A+D++ + G + ++ + + G KH+ + DG G Sbjct: 5 EFIIPAVDIKEGRAVRLYKGDPNAVKVYGDNPVEIAKRWEEKGAKHLHI--VDLDGAFEG 62 Query: 182 S--NVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGK 232 N + E++ + V + GG+ + V + GV V++G + K Sbjct: 63 IPKNYKIVEQIV-KSVNVPIEFGGGLRTYEAVKKMIEIGVERVVIGSLAYQDK 114 >UniRef50_Q6R3G3 Conserved protein n=1 Tax=Methylomonas sp. LW13 RepID=Q6R3G3_9GAMM Length = 227 Score = 132 bits (334), Expect = 8e-30, Method: Composition-based stats. Identities = 43/243 (17%), Positives = 83/243 (34%), Gaps = 35/243 (14%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLP---------RLQDYAAQGAEVLHLVDLT 52 IIP +DL DG VV GD + + ++ DL Sbjct: 3 IIPVIDLKDGLVVYAAGGDRSRYQPVHYTSSICESSEISNVVTSLLKLYPFPKFYIADLD 62 Query: 53 GAKDPAKRQIPLIKTL-VAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM 111 A I L N + G S + + A + V+G+ + + Sbjct: 63 -AIGGQGNHDEAIDNLFRQYPNKEFWLDKG-SSYQALTMTNRASNCKPVIGTESQRLPIS 120 Query: 112 VKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 +K L+L+LD + ++ GW ++ + + + Sbjct: 121 LKN-------TDLILSLDFKHNQVLGH----PGWLDS------------PELWPETNVVM 157 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEG 231 + G+ G + + +C +P F ++GG+ ++ D+ L+ G+ V++ AL G Sbjct: 158 TLDLVGSNQGPDFAKLSRLCQDHPDKHFVAAGGVRNVKDLMRLKTIGITAVLLASALHNG 217 Query: 232 KFT 234 Sbjct: 218 SID 220 >UniRef50_Q6R3H4 Conserved protein n=1 Tax=Methylosinus sp. LW2 RepID=Q6R3H4_9RHIZ Length = 230 Score = 132 bits (332), Expect = 1e-29, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 85/243 (34%), Gaps = 31/243 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRD------YGNDPLPRLQDYAA-QGAEVLHLVDLTGA 54 +IP +D+ +G VR GD +DPL + E +++ DL Sbjct: 3 VIPVIDIRNGVAVRAVAGDRKNYAPLTTPLAATSDPLDVARGLMTLHPFEAIYVADLDAI 62 Query: 55 KDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKG 114 + + + A + + G +V A V GS ++ D ++ Sbjct: 63 ERRGNNRTSIAAIAKAIAPARLWLDAGFTGALEVGAWRSLENVDPVFGSETLQESDDLRA 122 Query: 115 WFERFGADALVLALDVRIDEQ-GNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 +L+LD G+ ++ ++ + Sbjct: 123 ------DKHAILSLDFSTRSFLGDPRLYDD-----------------ESFWPDRLIVMTL 159 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKF 233 SR G G +VS + +V AR ++GG +DD+ L+ G G +V AL EG+ Sbjct: 160 SRVGAKQGPDVSRFYDVAARAGSRQVCAAGGARGLDDLLVLKEAGAAGALVATALHEGRL 219 Query: 234 TVK 236 T Sbjct: 220 TPA 222 >UniRef50_A2SJ37 HisA/HisF family protein, putative n=3 Tax=Burkholderiales RepID=A2SJ37_METPP Length = 273 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 60/247 (24%), Positives = 99/247 (40%), Gaps = 33/247 (13%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDY------GNDPLPRLQDYAAQGA-EVLHLVDLTGA 54 IIP +DL+DG VVR +G+ R DP + A + L+L DL A Sbjct: 3 IIPVIDLLDGQVVRAVRGERRHYRAIASALCGSADPRIVARRLCEHCATDTLYLADLN-A 61 Query: 55 KDPAKRQIPLIKTLVA-GVNVPVQVGGGVRSEEDVAALLE----AGVARV--VVGSTAVK 107 Q+ ++TL+ ++ + + G +D A LL ARV V GS +++ Sbjct: 62 LQGRPPQLEWLRTLLQDRPDLALWLDAGFSGPDDAAHLLARLEPTAAARVTPVYGSESLR 121 Query: 108 SQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 S++ + F +L+LD R + V + Sbjct: 122 SRETLAACFA--PPSRALLSLDHRQGAPLDP----------------AGVWELPAQWPRR 163 Query: 168 VLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRA 227 ++ +SR G+ G ++ V AR P +GG+ D D+AA + G +V A Sbjct: 164 LIVMTLSRVGSDGGPDLDTLAAVRARAPHAQLIGAGGVRDAADLAAAQAAGAHAWLVASA 223 Query: 228 LLEGKFT 234 L +G+ Sbjct: 224 LHDGRLP 230 >UniRef50_C2G0W0 Possible imidazoleglycerol-phosphate synthase HisF n=1 Tax=Sphingobacterium spiritivorum ATCC 33300 RepID=C2G0W0_9SPHI Length = 263 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 81/183 (44%), Gaps = 3/183 (1%) Query: 44 EVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGS 103 + L +++++ + + LV G +PV VGGG+RS ED L ++G ++V+ + Sbjct: 48 DELVILNVSRKSKNQEEFGRTVSRLVEGTYMPVAVGGGIRSLEDAEMLFKSGADKIVLNT 107 Query: 104 TAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPV 163 + D+VK +++G+ ++V ++D + + ++ + N E + + Sbjct: 108 SLSSDPDLVKLIVQKYGSQSVVASIDYLKKGESS-EIFIENGSLNINEGFENYLSHLKDL 166 Query: 164 GLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVRGV 222 + V + RDGT G + SL ++ V +GG G+ + L + + Sbjct: 167 NVGEVYLNSMERDGTGFGYDFSLV-KLVKSILNVPLIIAGGAGNEGHLKEALLHSEISAA 225 Query: 223 IVG 225 Sbjct: 226 ATA 228 >UniRef50_A2CB98 Putative uncharacterized protein n=1 Tax=Prochlorococcus marinus str. MIT 9303 RepID=A2CB98_PROM3 Length = 266 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 32/185 (17%), Positives = 82/185 (44%), Gaps = 3/185 (1%) Query: 43 AEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVG 102 + L ++D++ K ++R ++K L + +P+ GGG+ S + L ++G ++++ Sbjct: 49 IDELLVIDVSRKKRNSQRFCSMLKKLSSDCFLPIGAGGGLDSLDKAKMLFDSGADKLILN 108 Query: 103 STAVKSQDMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVE-TYL 161 ++ ++ +++K + +G A++ ++D++ +E G + + + SL+ Sbjct: 109 TSVYENPELIKALNKFYGQQAIIASVDIKKNELGIFDIYTHNGTKKAS-SLKDYQNIICK 167 Query: 162 PVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAA-LRGTGVR 220 + + + RDGT G + ++ + + +GG G + L GV Sbjct: 168 NEWIGELYLNSMERDGTGQGYDFNMLKSFTNLNKKHPIILAGGAGKTSHIVEGLLTDGVD 227 Query: 221 GVIVG 225 Sbjct: 228 ACATA 232 >UniRef50_C4ZG69 APG10 (Albino and pale green 10); 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imid azole-4-carboxamide isomerase n=3 Tax=cellular organisms RepID=C4ZG69_EUBR3 Length = 261 Score = 131 bits (329), Expect = 3e-29, Method: Composition-based stats. Identities = 52/257 (20%), Positives = 95/257 (36%), Gaps = 19/257 (7%) Query: 4 PALDLIDGTVVRLHQG------DYGKQRDYGN-DPLPRLQDYAAQGAEVLHLVDLTGAKD 56 P +D+ +G V ++ G D+ + D Y G + H++ L Sbjct: 5 PCIDIHNGKVKQIVGGSLKDRGDFASENFVSEQDSRFYADMYRKSGIKGGHIILLNSVDS 64 Query: 57 PAKRQIPLIKTLV-AGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM---- 111 + +QVGGG+ + ++ ++AG A V+V S K + Sbjct: 65 EYYEDTKEQAVMALEAYPQGLQVGGGI-TADNAMEFIDAGAAAVIVTSYVFKDGRINYAN 123 Query: 112 VKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCT 171 + + G+D LVL L R G + WQ + ++ + L L Sbjct: 124 LNRLKDTVGSDRLVLDLSCRKK-DGQYYIVTDRWQNFTDEAVTTELLDKLSSYCCEFLVH 182 Query: 172 DISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVR--GVIVGRA-- 227 + +G + G L + + + ++ +GG+ DD+ +R G V +G A Sbjct: 183 AVDVEGRVNGIEKELVAMLGS-WGRIPVTYAGGVSSFDDLKCIRQLGQNHLNVTIGSALD 241 Query: 228 LLEGKFTVKEAIACWQN 244 L G+ + IA N Sbjct: 242 LFGGEMEYDKVIAFCNN 258 >UniRef50_O82782 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic n=33 Tax=cellular organisms RepID=HIS4_ARATH Length = 304 Score = 130 bits (328), Expect = 3e-29, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 96/256 (37%), Gaps = 27/256 (10%) Query: 4 PALDLIDGTVVRLHQGDYGKQRDYGN----------DPLPRLQDYAAQGAEVLHLVDLTG 53 P +D+ G V ++ ++ G+ + Y G H++ L Sbjct: 48 PCIDIHKGKVKQIVGSTLRDLKEDGSVLVTNFESDKSAEEYAKMYKEDGLTGGHVIMLGA 107 Query: 54 AKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKS----Q 109 Q I L A +QVGGG+ S E+ + +E G + V+V S + Sbjct: 108 ---DPLSQAAAIGALHAYPGG-LQVGGGINS-ENCMSYIEEGASHVIVTSYVFNNGKIDL 162 Query: 110 DMVKGWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVL 169 + +K G L+L L R G + WQ+ S V L++ +L L Sbjct: 163 ERLKDIVSIVGKQRLILDLSCRKK-DGRYAIVTDRWQKFSDVILDEKSLEFLGGFSDEFL 221 Query: 170 CTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTG---VRGVIVGR 226 + +G G + L + Y + +GG+ +DDV ++ G V V VG Sbjct: 222 VHGVDVEGKKLGIDEELVA-LLGNYSPIPVTYAGGVTVMDDVERIKDAGKGRVD-VTVGS 279 Query: 227 AL--LEGKFTVKEAIA 240 AL G K+ +A Sbjct: 280 ALDIFGGNLPYKDVVA 295 >UniRef50_C7NHA2 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NHA2_KYTSD Length = 470 Score = 130 bits (328), Expect = 4e-29, Method: Composition-based stats. Identities = 64/247 (25%), Positives = 99/247 (40%), Gaps = 21/247 (8%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQ 61 + PA+D+ G R Q D +DP + + AQGAE LHLVDL A A Sbjct: 5 LWPAVDVRGG---RTAQVDPDSPL---SDPQAAVDHWVAQGAERLHLVDLDRA-TGAGEN 57 Query: 62 IPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGA 121 L++ LV +VPV+V GG+ S DV L G V S W + GA Sbjct: 58 DALLERLVRRASVPVEVSGGILSPRDVERALSWGAVAVTTSSALWADPAAALEWLQGCGA 117 Query: 122 DALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGTLAG 181 + + + +D+ D V+ + + + L +G + + + DG + G Sbjct: 118 E-VQVGIDLVGDR------VVARGTDLALGPVADLWPDLAGLGERRWVLASAAADGRMTG 170 Query: 182 SNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGT-GVRG-----VIVGRALLEGKFTV 235 +++ +SGG+ D+ A+ GV G VI+G AL G + Sbjct: 171 PDLAGLRAATEHLTGT-LIASGGVSTTGDLVAVSSLRGVAGPAVGEVILGAALYAGAVDL 229 Query: 236 KEAIACW 242 A Sbjct: 230 GRAQRLL 236 >UniRef50_Q2FS89 Histidine biosynthesis n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FS89_METHJ Length = 226 Score = 129 bits (326), Expect = 6e-29, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 79/238 (33%), Gaps = 28/238 (11%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYGN---DPLPRLQDYAAQGAEVLHLVDLTGAKDPA 58 + A DL G +V G + + D ++ L++ DL Sbjct: 3 LYLATDLKSGKIVHGKSGMRDRYVPVTSLHADTAEPIRFIEQMKPRFLYIADLDRI-CGT 61 Query: 59 KRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFER 118 PLI L + + G + D+ + GV+ +V TA + Sbjct: 62 GDHDPLIPELAERTE-RILLDRGCKGPYDMLDIF--GVSMIVGTETAADTLAQFTKG--- 115 Query: 119 FGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDISRDGT 178 VL++D++ D + + T + V+ DI R GT Sbjct: 116 ------VLSVDIKNDLVIPW-----------NIDPVTFLSTCNRYRFEMVILLDIGRVGT 158 Query: 179 LAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVK 236 G + + + Y GG+ +D+A L G G I+ A+ GK V+ Sbjct: 159 GRGLDKEMLSQFREVYTG-PLLWGGGVSSEEDLALLEKAGFDGAIIATAVHSGKIPVE 215 Score = 51.3 bits (122), Expect = 3e-05, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 36/90 (40%) Query: 26 DYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSE 85 + DP+ L E++ L+D+ ++ P+ GGGV SE Sbjct: 128 PWNIDPVTFLSTCNRYRFEMVILLDIGRVGTGRGLDKEMLSQFREVYTGPLLWGGGVSSE 187 Query: 86 EDVAALLEAGVARVVVGSTAVKSQDMVKGW 115 ED+A L +AG ++ + + V+ Sbjct: 188 EDLALLEKAGFDGAIIATAVHSGKIPVEYI 217 >UniRef50_C1ZC07 HisA/hisF family protein n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZC07_PLALI Length = 296 Score = 129 bits (325), Expect = 8e-29, Method: Composition-based stats. Identities = 49/278 (17%), Positives = 95/278 (34%), Gaps = 51/278 (18%) Query: 1 MIIPALDLIDGTVVRLHQGDYGKQRDYGND------PLPRLQDYAA-QGAEVLHLVDLTG 53 +++P +D +G V G+ R + + P ++++ L++ DL G Sbjct: 22 VVVPVIDTRNGWAVHAIAGNRALYRPWTDSFQQPRKPQQLAEEFSRVWQPRWLYVADLDG 81 Query: 54 AKDPAKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 D + + G + + G R +DV + G V++G+ ++ S ++ Sbjct: 82 IIDGQPQTSSW--PCLPGDGPRILMDAGFREIDDVLTAVNLGYE-VILGTESLPSMAWLQ 138 Query: 114 GWFERF-GADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTD 172 R + L ++LD R + E + L + + H + D Sbjct: 139 ELIVRLEDSQRLWISLDFRQGQWQAP-------AEFQQLGLTDFISQLSNWSMTHWIVLD 191 Query: 173 ISRDGTLAGS----NVSLYEEVCARYPQ-----------------------VA------F 199 ++ G G + L E + + V Sbjct: 192 LADVGQGTGGSTAEQIRLLRETLEKSSRNWKHPAESYQSRLAQSCQHGTQVVPTERTPTI 251 Query: 200 QSSGGIGDIDDVAALRGTGVRGVIVGRALLEGKFTVKE 237 + GG+ DV L+ GV GV+V AL+ G T + Sbjct: 252 LAGGGMRTAQDVLQLQTQGVSGVLVATALMTGTITPDQ 289 >UniRef50_A7IL67 Histidine biosynthesis protein n=2 Tax=Alphaproteobacteria RepID=A7IL67_XANP2 Length = 235 Score = 129 bits (324), Expect = 1e-28, Method: Composition-based stats. Identities = 52/251 (20%), Positives = 89/251 (35%), Gaps = 32/251 (12%) Query: 2 IIPALDLIDGTVVRLHQGDYGKQRDYG------NDPLPR-LQDYAAQGAEVLHLVDLTGA 54 +IP +DL G VV +G+ R + PL A L++ DL A Sbjct: 3 LIPVVDLKGGYVVHARRGERDSYRPIHTPLAATSAPLDVVAGLLALAPFRTLYVADLD-A 61 Query: 55 KDPAKRQIPLIKTLVAGVN-VPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVK 113 +I L A + + V G + V A G V+G+ + K Sbjct: 62 IAGKGSHGAVIDGLRAAFPRLDLWVDAGEARADQVHARAAQGRGFCVIGTETLPDVAAAK 121 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 A ++L+LD V+V + + V+ + Sbjct: 122 DVLA---AGDVILSLD-HDAAGPRGPVSVH---------------EDPALWPERVIVMTL 162 Query: 174 SRDGTLAGSNVSLYEEVCARYPQV----AFQSSGGIGDIDDVAALRGTGVRGVIVGRALL 229 +R G+ G +++ E AR + + ++GG+ +D+ L G GV+V AL Sbjct: 163 ARVGSGEGPDLAALERTAARADGIGRHPSLYAAGGVRGPEDLDRLAAMGTAGVLVASALH 222 Query: 230 EGKFTVKEAIA 240 +G+ A Sbjct: 223 DGRIGPDTARR 233 >UniRef50_UPI00006DC778 hypothetical protein CdifQ_04001754 n=1 Tax=Clostridium difficile QCD-32g58 RepID=UPI00006DC778 Length = 164 Score = 128 bits (322), Expect = 2e-28, Method: Composition-based stats. Identities = 39/153 (25%), Positives = 76/153 (49%) Query: 15 RLHQGDYGKQRDYGNDPLPRLQDYAAQGAEVLHLVDLTGAKDPAKRQIPLIKTLVAGVNV 74 + +G K + P + Y+ GA+ L D+T + + K + + + +N+ Sbjct: 8 KSCKGKKFKDIVDVDSPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENINI 67 Query: 75 PVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDMVKGWFERFGADALVLALDVRIDE 134 P VGGGV ED +L G +V + S+AVK+ ++++ +FGA +VL++D + +E Sbjct: 68 PFCVGGGVNKLEDFTDILRKGADKVSINSSAVKNPELIREASLKFGAQCVVLSIDAKKNE 127 Query: 135 QGNKQVAVSGWQENSGVSLEQLVETYLPVGLKH 167 +G+ V V G +E + + +G++ Sbjct: 128 EGSWSVYVKGGREKLIWMQLNGLLKVVELGVRR 160 Score = 42.8 bits (100), Expect = 0.010, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 29/76 (38%), Gaps = 1/76 (1%) Query: 152 SLEQLVETYLPVGLKHVLCTDISRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV 211 S E L + Y G ++ DI+ +++ +V + F GG+ ++D Sbjct: 23 SPEVLGKFYSDCGADELVFYDITASNEERKTSLEFVTKVAENI-NIPFCVGGGVNKLEDF 81 Query: 212 AALRGTGVRGVIVGRA 227 + G V + + Sbjct: 82 TDILRKGADKVSINSS 97 >UniRef50_Q10184 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase n=71 Tax=cellular organisms RepID=HIS4_SCHPO Length = 264 Score = 127 bits (321), Expect = 2e-28, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 86/238 (36%), Gaps = 23/238 (9%) Query: 4 PALDLIDGTVVRLHQGDYGKQRDYGNDPLPR------LQDYAAQGAEVLHLVDLTGAKDP 57 P +D+ G V ++ G G D + + + Y E H++ L Sbjct: 11 PCIDIHQGQVKQIVGGTLGNDADVKTNYVSLKPSSYYAELYKLNHLEGAHVIML------ 64 Query: 58 AKRQIPLIKTLVAGVNVPVQVGGGVRSEEDVAALLEAGVARVVVGSTAVKSQDM----VK 113 KT + +Q+GGG+ + + L+ G ++V+V S +K Sbjct: 65 GPNCEEAAKTALHTWPGALQIGGGI-NISNAQNWLQEGASKVIVTSWLFPDAQFDLDRLK 123 Query: 114 GWFERFGADALVLALDVRIDEQGNKQVAVSGWQENSGVSLEQLVETYLPVGLKHVLCTDI 173 + G D LV+ + R + A++ WQ + L + L L Sbjct: 124 AISSKIGKDRLVVDVSCRRKDN-RWFAAINKWQVMTAFELNEENLDLLSQYCSEFLIHAA 182 Query: 174 SRDGTLAGSNVSLYEEVCARYPQVAFQSSGGIGDIDDV---AALRGTGVRGVIVGRAL 228 +G G + L ++ + ++ +GG I+D+ L V + +G AL Sbjct: 183 DVEGLCKGIDEDLVIKLG-EWVKIPTTYAGGGRSIEDLDLVDKLSKGKVD-LTIGSAL 238 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.314 0.163 0.451 Lambda K H 0.267 0.0502 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,716,350,651 Number of Sequences: 3077464 Number of extensions: 81747681 Number of successful extensions: 271881 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1103 Number of HSP's successfully gapped in prelim test: 1452 Number of HSP's that attempted gapping in prelim test: 264852 Number of HSP's gapped (non-prelim): 4527 length of query: 245 length of database: 1,040,396,356 effective HSP length: 125 effective length of query: 120 effective length of database: 655,713,356 effective search space: 78685602720 effective search space used: 78685602720 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 92 (39.8 bits)